SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 Gene3D G3DSA:3.40.50.720 177 306 1.9E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 33 141 2.9E-25 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 SMART SM00829 10 341 2.5E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 Pfam PF00107 Zinc-binding dehydrogenase 183 299 5.9E-14 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 SUPERFAMILY SSF50129 23 181 1.28E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 Gene3D G3DSA:3.90.180.10 25 176 7.2E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 68 82 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS20370 e25a1c18c0b475ed159f7fa3f7787ac2 347 SUPERFAMILY SSF51735 150 310 2.93E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 Gene3D G3DSA:3.40.50.720 157 300 9.3E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 SMART SM00829 9 325 1.2E-15 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 SUPERFAMILY SSF50129 12 159 5.63E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 Gene3D G3DSA:3.90.180.10 5 156 1.6E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 Pfam PF00107 Zinc-binding dehydrogenase 164 287 7.6E-23 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 88 2.7E-11 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS42260 f44afee9758e4edb59217b3e54c19c0e 327 SUPERFAMILY SSF51735 129 298 2.25E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 ProSitePatterns PS00211 ABC transporters family signature. 175 189 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 Pfam PF00005 ABC transporter 44 202 1.8E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 Gene3D G3DSA:3.40.50.300 22 276 2.3E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 252 332 3.3E-27 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 SMART SM00382 52 252 6.1E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 254 318 1.6E-21 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33860 9a8469f8aa95ea01234e1782b2fe6826 352 SUPERFAMILY SSF52540 53 326 9.74E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03455 4e57ef54b65faec5193665901bd268b7 390 SUPERFAMILY SSF50939 59 273 3.14E-19 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS03455 4e57ef54b65faec5193665901bd268b7 390 Pfam PF13088 BNR repeat-like domain 77 267 1.7E-7 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS03455 4e57ef54b65faec5193665901bd268b7 390 SUPERFAMILY SSF75005 232 351 6.06E-5 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS03455 4e57ef54b65faec5193665901bd268b7 390 Gene3D G3DSA:2.120.10.10 59 333 3.3E-17 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 SMART SM00382 359 504 1.7E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 SUPERFAMILY SSF54211 612 790 1.14E-51 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 584 792 7.6E-76 T 17-03-2017 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 SUPERFAMILY SSF52540 310 567 3.97E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 364 499 3.1E-20 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Gene3D G3DSA:1.10.8.60 512 594 2.7E-26 T 17-03-2017 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 746 764 9.8E-51 T 17-03-2017 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 693 712 9.8E-51 T 17-03-2017 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 612 628 9.8E-51 T 17-03-2017 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 367 386 9.8E-51 T 17-03-2017 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 723 742 9.8E-51 T 17-03-2017 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 TIGRFAM TIGR00763 lon: endopeptidase La 11 791 8.7E-241 T 17-03-2017 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Gene3D G3DSA:3.40.50.300 309 511 4.3E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 SMART SM00464 9 203 1.2E-20 T 17-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Hamap MF_01973 Lon protease [lon]. 10 792 59.077 T 17-03-2017 IPR027543 Lon protease, bacterial GO:0004176|GO:0004252|GO:0005524|GO:0006508|GO:0043565 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 SUPERFAMILY SSF88697 9 201 1.84E-23 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 PIRSF PIRSF001174 1 795 1.0E-246 T 17-03-2017 IPR004815 Lon protease, bacterial/eukaryotic-type GO:0004176|GO:0005524|GO:0006508 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Gene3D G3DSA:3.30.230.10 607 791 1.9E-69 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 9 202 1.3E-17 T 17-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 SHXM_RS34870 39b1ac3498df09d4949f7677bfbfc39d 805 ProSitePatterns PS01046 ATP-dependent serine proteases, lon family, serine active site. 696 704 - T 17-03-2017 IPR008268 Peptidase S16, active site GO:0004176|GO:0004252|GO:0006508 SHXM_RS05180 72e6499f5ea94bb3a50811ef7199765e 355 Gene3D G3DSA:2.160.20.10 45 347 3.6E-80 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS05180 72e6499f5ea94bb3a50811ef7199765e 355 Pfam PF00544 Pectate lyase 110 275 6.2E-19 T 17-03-2017 IPR002022 Pectate lyase/Amb allergen SHXM_RS05180 72e6499f5ea94bb3a50811ef7199765e 355 SUPERFAMILY SSF51126 52 348 1.49E-62 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS05180 72e6499f5ea94bb3a50811ef7199765e 355 SMART SM00656 72 291 3.4E-14 T 17-03-2017 IPR002022 Pectate lyase/Amb allergen SHXM_RS08775 d60bd8be646ae4bb2dbfa274578094b6 315 Pfam PF12666 PrgI family protein 13 101 7.4E-15 T 17-03-2017 IPR024414 Uncharacterised protein family PrgI SHXM_RS34195 437e20673304d50724b7d3d815201db2 248 Pfam PF13794 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE)-like 32 216 2.7E-96 T 17-03-2017 SHXM_RS34195 437e20673304d50724b7d3d815201db2 248 SUPERFAMILY SSF47240 38 159 3.08E-9 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS34195 437e20673304d50724b7d3d815201db2 248 Gene3D G3DSA:1.20.1260.10 36 161 2.0E-8 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Hamap MF_00277 Bifunctional uridylyltransferase/uridylyl-removing enzyme [glnD]. 1 871 95.861 T 17-03-2017 IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme GO:0006807|GO:0008773 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Gene3D G3DSA:3.30.70.260 796 850 7.0E-9 T 17-03-2017 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 SUPERFAMILY SSF109604 419 569 6.59E-16 T 17-03-2017 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Gene3D G3DSA:3.30.460.10 67 127 3.4E-4 T 17-03-2017 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 SUPERFAMILY SSF55021 796 848 8.02E-8 T 17-03-2017 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 PIRSF PIRSF006288 3 871 5.9E-195 T 17-03-2017 IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme GO:0006807|GO:0008773 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 TIGRFAM TIGR01693 UTase_glnD: protein-P-II uridylyltransferase 24 863 3.1E-239 T 17-03-2017 IPR010043 Bifunctional uridylyltransferase/uridylyl-removing enzyme GO:0006807|GO:0008773 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Pfam PF01909 Nucleotidyltransferase domain 65 127 4.0E-5 T 17-03-2017 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Pfam PF08335 GlnD PII-uridylyltransferase 177 214 3.5E-5 T 17-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Pfam PF08335 GlnD PII-uridylyltransferase 215 287 4.8E-5 T 17-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 SUPERFAMILY SSF81301 40 163 8.18E-15 T 17-03-2017 SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Gene3D G3DSA:1.10.3210.10 430 594 9.4E-20 T 17-03-2017 IPR006674 HD domain SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 Pfam PF01966 HD domain 453 570 2.9E-13 T 17-03-2017 IPR006674 HD domain SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 SMART SM00471 448 580 1.4E-8 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS36545 4b99d432ec9030d160264765b12b476c 871 SUPERFAMILY SSF81593 176 285 1.88E-5 T 17-03-2017 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 Pfam PF00547 Urease, gamma subunit 1 99 1.1E-46 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 Gene3D G3DSA:3.30.280.10 1 99 1.2E-48 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 Hamap MF_00739 Urease subunit gamma [ureA]. 1 100 33.708 T 17-03-2017 IPR012010 Urease, gamma subunit GO:0009039|GO:0019627 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 TIGRFAM TIGR00193 urease_gam: urease, gamma subunit 1 99 7.0E-51 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 PIRSF PIRSF001223 1 100 7.2E-51 T 17-03-2017 IPR012010 Urease, gamma subunit GO:0009039|GO:0019627 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 ProDom PD002319 SUBUNIT GAMMA HYDROLASE UREASE UREA AMIDOHYDROLASE UREASE ALPHA GAMMA/BETA METAL-BINDING 9 99 1.0E-40 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08475 d433d2fb9629c85db90eb97e22a0a89d 100 SUPERFAMILY SSF54111 1 99 3.27E-45 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 Gene3D G3DSA:1.10.10.10 6 55 8.5E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 Gene3D G3DSA:3.30.70.920 59 148 1.4E-18 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 SMART SM00344 7 116 1.3E-31 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 SUPERFAMILY SSF54909 69 151 4.96E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 Pfam PF01037 Lrp/AsnC ligand binding domain 74 146 8.0E-14 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 Pfam PF13404 AsnC-type helix-turn-helix domain 7 48 7.4E-17 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 SUPERFAMILY SSF46785 6 66 6.04E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 7 23 7.7E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 34 53 7.7E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS08665 01623db68dfcf05be20013aa3130f307 164 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 23 34 7.7E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SMART SM00560 676 810 2.8E-27 T 17-03-2017 IPR006558 LamG-like jellyroll fold SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF00703 Glycosyl hydrolases family 2 277 387 7.1E-16 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:2.60.40.10 1280 1370 2.4E-8 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF49785 65 275 1.23E-53 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF16353 Domain of unknown function(DUF4981) 881 967 1.8E-17 T 17-03-2017 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 104 275 5.5E-39 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 1294 1370 2.2E-8 T 17-03-2017 IPR018905 Alpha-galactosidase, NEW3 domain SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 389 622 5.7E-69 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:2.70.98.10 982 1265 7.7E-79 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF02929 Beta galactosidase small chain 996 1262 1.2E-61 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SMART SM00776 1393 1538 2.1E-62 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF49899 627 814 3.66E-28 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SMART SM01038 994 1263 1.1E-72 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 660 812 2.3E-23 T 17-03-2017 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF51445 389 623 9.06E-66 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:3.20.20.80 386 614 2.6E-81 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:3.20.20.80 831 869 2.6E-81 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF49785 1397 1535 9.78E-40 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Pfam PF08305 NPCBM/NEW2 domain 1396 1536 2.6E-46 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 PRINTS PR00132 Glycosyl hydrolase family 2 signature 203 218 3.1E-29 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 PRINTS PR00132 Glycosyl hydrolase family 2 signature 398 412 3.1E-29 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 PRINTS PR00132 Glycosyl hydrolase family 2 signature 429 447 3.1E-29 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 PRINTS PR00132 Glycosyl hydrolase family 2 signature 503 518 3.1E-29 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 PRINTS PR00132 Glycosyl hydrolase family 2 signature 576 591 3.1E-29 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF49303 277 387 7.77E-22 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:2.60.40.320 870 969 2.6E-24 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:2.60.120.200 615 813 6.4E-28 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:2.60.40.320 265 385 4.0E-29 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF49303 865 969 3.17E-22 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 Gene3D G3DSA:2.60.120.260 64 264 3.0E-66 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS08045 5de06c14ec3ca836dda8b84a86706dc9 1547 SUPERFAMILY SSF74650 981 1265 1.26E-65 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 Gene3D G3DSA:1.20.1250.20 9 197 6.6E-30 T 17-03-2017 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 Gene3D G3DSA:1.20.1250.20 272 473 7.9E-14 T 17-03-2017 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 140 164 1.6E-5 T 17-03-2017 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 18 42 1.6E-5 T 17-03-2017 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 206 224 1.6E-5 T 17-03-2017 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 SUPERFAMILY SSF103473 6 199 5.1E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 SUPERFAMILY SSF103473 251 474 5.1E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 ProSitePatterns PS00216 Sugar transport proteins signature 1. 69 85 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 16 453 8.2E-74 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS32325 d5cb886dfe065207bfe1b753a13e854c 502 Pfam PF07690 Major Facilitator Superfamily 19 414 6.4E-53 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 403 509 1.4E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 270 2.2E-81 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF00698 Acyl transferase domain 545 857 4.3E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF51735 1169 1307 2.28E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF52151 730 825 1.46E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF52151 545 669 1.46E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.30.70.250 668 721 1.0E-7 T 17-03-2017 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.40.47.10 36 282 8.9E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF51735 1318 1545 1.82E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF47336 1572 1658 1.83E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 183 199 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SMART SM00825 Beta-ketoacyl synthase 36 445 6.2E-192 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 547 838 1.2E-112 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1319 1498 8.8E-59 T 17-03-2017 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF55048 668 727 8.63E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SMART SM00823 Phosphopantetheine attachment site 1580 1652 5.8E-25 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 278 394 1.2E-40 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF08659 KR domain 1320 1496 3.1E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF08990 Erythronolide synthase docking 2 27 2.7E-6 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:1.10.1200.10 1581 1653 3.0E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF00550 Phosphopantetheine attachment site 1582 1646 1.5E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SUPERFAMILY SSF53901 32 392 1.82E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 SMART SM00826 904 1057 2.2E-60 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.40.366.10 728 838 3.8E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.40.366.10 545 663 3.8E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.40.47.10 283 445 2.1E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Pfam PF14765 Polyketide synthase dehydratase 904 1163 3.4E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.40.50.720 1319 1500 2.5E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46800 8e87164fc735566e8ebeba78106ed14f 1726 Gene3D G3DSA:3.40.50.720 1565 1580 2.5E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07285 efcbe5726af8c161df91d4aafc1e51df 332 SUPERFAMILY SSF160240 232 303 8.24E-9 T 17-03-2017 SHXM_RS07285 efcbe5726af8c161df91d4aafc1e51df 332 Pfam PF01545 Cation efflux family 35 224 1.7E-41 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS07285 efcbe5726af8c161df91d4aafc1e51df 332 Gene3D G3DSA:1.20.1510.10 30 224 3.6E-49 T 17-03-2017 IPR027469 Cation efflux protein transmembrane domain SHXM_RS07285 efcbe5726af8c161df91d4aafc1e51df 332 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 30 303 3.0E-70 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS07285 efcbe5726af8c161df91d4aafc1e51df 332 SUPERFAMILY SSF161111 28 225 1.31E-48 T 17-03-2017 SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 SUPERFAMILY SSF53850 93 295 3.26E-32 T 17-03-2017 SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 Pfam PF03466 LysR substrate binding domain 101 294 5.7E-32 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 Gene3D G3DSA:1.10.10.10 4 87 1.7E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 SUPERFAMILY SSF46785 2 107 1.5E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 5.9E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 Gene3D G3DSA:3.40.190.10 179 267 9.2E-14 T 17-03-2017 SHXM_RS05665 3868abd9d7a673d1c66913de0d5024be 308 Gene3D G3DSA:3.40.190.10 101 178 6.2E-13 T 17-03-2017 SHXM_RS47670 74b3e8483a08c990735db23becfbeab9 231 Gene3D G3DSA:3.40.50.300 27 225 9.4E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47670 74b3e8483a08c990735db23becfbeab9 231 SUPERFAMILY SSF52540 24 227 4.87E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47670 74b3e8483a08c990735db23becfbeab9 231 PIRSF PIRSF005624 8 231 9.6E-49 T 17-03-2017 SHXM_RS47670 74b3e8483a08c990735db23becfbeab9 231 TIGRFAM TIGR00101 ureG: urease accessory protein UreG 29 221 2.1E-85 T 17-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 SHXM_RS47670 74b3e8483a08c990735db23becfbeab9 231 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 31 201 3.4E-34 T 17-03-2017 IPR003495 CobW/HypB/UreG, nucleotide-binding domain SHXM_RS47670 74b3e8483a08c990735db23becfbeab9 231 Hamap MF_01389 Urease accessory protein UreG [ureG]. 27 223 44.052 T 17-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 SMART SM00939 310 522 8.4E-24 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 Gene3D G3DSA:3.40.50.1820 21 186 8.2E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 Gene3D G3DSA:3.40.50.1820 238 337 8.2E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 53 291 1.3E-35 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 387 513 7.7E-17 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 SUPERFAMILY SSF49785 399 527 6.38E-16 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 Gene3D G3DSA:2.60.120.260 388 527 7.7E-17 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS14925 4a024c72bc11775f8c982f8e7d36ad22 528 SUPERFAMILY SSF53474 40 348 2.96E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 Pfam PF00106 short chain dehydrogenase 3 200 1.0E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 5.4E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 71 82 5.4E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 5.4E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 Gene3D G3DSA:3.40.50.720 1 232 1.3E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 1.9E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 1.9E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 1.9E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 1.9E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 71 82 1.9E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16190 a14d9ef5a27febb8785f7c91906db140 235 SUPERFAMILY SSF51735 3 231 9.1E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS29660 b62b794ef098d8edb303955692b54e19 134 SUPERFAMILY SSF55486 20 133 4.76E-37 T 17-03-2017 SHXM_RS29660 b62b794ef098d8edb303955692b54e19 134 Pfam PF06262 Zinicin-like metallopeptidase 46 132 3.4E-32 T 17-03-2017 IPR010428 Zinicin-like metallopeptidase SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00550 Phosphopantetheine attachment site 8117 8182 6.2E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00550 Phosphopantetheine attachment site 1492 1558 3.8E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00550 Phosphopantetheine attachment site 3048 3114 2.6E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00550 Phosphopantetheine attachment site 4421 4485 1.3E-7 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00550 Phosphopantetheine attachment site 5990 6056 9.6E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF50129 7516 7646 8.02E-28 T 17-03-2017 IPR011032 GroES-like SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 4507 4772 5.6E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 6245 6261 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF55048 5171 5236 4.97E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7829 8009 6.6E-65 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5706 5885 7.4E-61 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2763 2942 1.0E-54 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1206 1385 1.9E-61 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF53901 3136 3510 3.34E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6015 6030 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.30.70.250 3798 3863 5.2E-7 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.30.70.250 5171 5235 4.1E-8 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.30.70.250 6745 6809 5.1E-8 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.30.70.250 696 759 3.2E-8 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.30.70.250 2247 2311 5.2E-7 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00698 Acyl transferase domain 568 890 8.6E-60 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00698 Acyl transferase domain 6618 6940 2.8E-59 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00698 Acyl transferase domain 2120 2442 1.1E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00698 Acyl transferase domain 3671 3998 4.6E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00698 Acyl transferase domain 5045 5364 5.8E-94 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00829 7513 7819 7.7E-188 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.90.180.10 7527 7645 2.0E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF53901 6079 6455 9.82E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF101173 3 33 7.85E-6 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 1202 1454 3.66E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.50.720 5707 5922 4.3E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.50.720 2762 2944 5.9E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.50.720 7829 8040 1.9E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.50.720 1207 1419 9.2E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 3864 3957 5.75E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 3668 3800 5.75E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 7641 7662 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 2539 2750 5.12E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 7272 7347 9.05E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 7374 7490 9.05E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF53901 31 406 3.19E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:1.10.1200.10 4416 4489 3.5E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:1.10.1200.10 3044 3118 9.8E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:1.10.1200.10 8113 8186 7.2E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:1.10.1200.10 5986 6060 2.5E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:1.10.1200.10 1488 1564 3.0E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF55048 6746 6810 1.16E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1584 1834 2.2E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4510 4760 1.2E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6082 6332 4.7E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3138 3388 3.4E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 3.2E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF55048 696 760 4.84E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1517 1532 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF14765 Polyketide synthase dehydratase 6990 7262 9.9E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF14765 Polyketide synthase dehydratase 4048 4330 1.5E-51 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00825 Beta-ketoacyl synthase 4512 4938 5.8E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00825 Beta-ketoacyl synthase 3140 3566 7.5E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00825 Beta-ketoacyl synthase 6084 6510 9.9E-223 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00825 Beta-ketoacyl synthase 1586 2012 1.6E-219 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00825 Beta-ketoacyl synthase 36 462 1.5E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00012 Phosphopantetheine attachment site. 8141 8156 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 5557 5693 8.27E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 5459 5526 8.27E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 2759 2984 1.21E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 5044 5172 6.8E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 5237 5335 6.8E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF55048 2248 2312 2.22E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 4673 4689 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF47336 1485 1599 1.03E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF47336 3044 3153 2.49E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF47336 5982 6097 4.97E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1842 1959 1.1E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 4768 4885 7.8E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 1.4E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3396 3513 4.4E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 6340 6457 1.6E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 7828 8039 3.48E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 981 1192 2.14E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00823 Phosphopantetheine attachment site 1490 1562 5.1E-27 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00823 Phosphopantetheine attachment site 4418 4490 2.3E-25 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00823 Phosphopantetheine attachment site 8114 8186 2.8E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00823 Phosphopantetheine attachment site 3046 3118 4.5E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00823 Phosphopantetheine attachment site 5988 6060 7.4E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.50.720 7646 7741 2.4E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 7533 7590 5.6E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF08990 Erythronolide synthase docking 3 27 7.7E-13 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 3659 3795 1.9E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 3864 3994 1.9E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 5236 5359 2.0E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 5037 5167 2.0E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 36 296 6.6E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 6084 6344 1.1E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 3140 3400 4.7E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 1586 1846 7.7E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 5705 5937 3.64E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 6460 6580 1.2E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1962 2084 3.3E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3516 3632 1.5E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 4888 5006 3.6E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 529 8.9E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1747 1763 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF47336 4415 4525 5.76E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM01294 5989 6056 2.5E-5 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM01294 8115 8182 4.2E-5 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM01294 1491 1558 3.9E-5 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM01294 4419 4486 5.8E-4 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM01294 3047 3114 1.1E-6 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3301 3317 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 6616 6741 1.28E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 6803 6904 1.28E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 4773 4938 6.0E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 3401 3566 1.3E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 297 463 1.9E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 1847 2013 1.1E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.47.10 6345 6511 5.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF51735 7613 7790 1.01E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 2118 2249 1.75E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 2313 2412 1.75E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 6619 6922 1.2E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 569 871 1.8E-134 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2121 2423 1.3E-131 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5047 5345 1.9E-124 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3672 3981 1.3E-132 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00826 4048 4220 4.9E-69 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SMART SM00826 6990 7153 3.1E-86 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF13602 Zinc-binding dehydrogenase 7688 7819 4.0E-16 T 17-03-2017 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF53901 1580 1949 7.69E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF53901 4507 4883 2.88E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF47336 8107 8195 1.7E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF08659 KR domain 5706 5883 1.7E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF08659 KR domain 1206 1384 2.5E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF08659 KR domain 2763 2941 2.0E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Pfam PF08659 KR domain 7829 8007 1.3E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 6613 6741 2.4E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 2114 2243 1.7E-84 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 563 691 3.6E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 760 875 3.6E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 2312 2427 1.7E-84 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 Gene3D G3DSA:3.40.366.10 6810 6926 2.4E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 566 691 4.19E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF52151 753 856 4.19E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45365 4897e32c753116ea0d20c992811ce7b1 8277 SUPERFAMILY SSF55048 3799 3863 2.22E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 Gene3D G3DSA:3.40.50.2300 76 188 6.0E-26 T 17-03-2017 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 SUPERFAMILY SSF53822 77 353 2.94E-66 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 32 42 8.0E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 22 32 8.0E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 Gene3D G3DSA:3.40.50.2300 189 352 3.5E-52 T 17-03-2017 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 Gene3D G3DSA:1.10.260.40 21 65 4.3E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 ProSitePatterns PS00356 LacI-type HTH domain signature. 23 41 - T 17-03-2017 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 SUPERFAMILY SSF47413 21 67 9.96E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 Pfam PF13377 Periplasmic binding protein-like domain 189 351 1.8E-36 T 17-03-2017 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 SMART SM00354 20 87 7.9E-23 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19285 de95e604a036bf16fe0d4dc55fdd5dcd 368 Pfam PF00356 Bacterial regulatory proteins, lacI family 23 65 1.4E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF13602 Zinc-binding dehydrogenase 1592 1719 4.6E-18 T 17-03-2017 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.40.50.720 1729 1913 5.7E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF14765 Polyketide synthase dehydratase 938 1218 1.2E-57 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM00829 1414 1719 1.4E-176 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.40.47.10 37 297 9.6E-79 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.40.366.10 759 870 2.1E-67 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.40.366.10 567 690 2.1E-67 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF50129 1427 1546 5.66E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 571 870 1.6E-102 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1729 1909 6.0E-57 T 17-03-2017 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF51735 1226 1391 1.28E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF52151 567 696 8.89E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF52151 761 859 8.89E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM01294 2014 2081 1.0E-5 T 17-03-2017 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 3.1E-78 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF51735 1729 1936 3.14E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 8.3E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM00825 Beta-ketoacyl synthase 37 463 1.2E-189 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF00698 Acyl transferase domain 570 888 4.0E-73 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.30.70.250 695 758 1.9E-7 T 17-03-2017 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF51735 1512 1648 1.43E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.40.47.10 298 464 7.5E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1434 1489 1.5E-4 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF55048 695 759 4.45E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:1.10.1200.10 2011 2085 1.5E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF00550 Phosphopantetheine attachment site 2015 2081 1.7E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM00823 Phosphopantetheine attachment site 2013 2085 3.7E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF08659 KR domain 1729 1907 3.9E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2040 2055 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF47336 2006 2093 1.7E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SMART SM00826 938 1107 4.9E-82 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 1541 1562 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 530 4.6E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.90.180.10 1430 1547 2.3E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 Gene3D G3DSA:3.40.50.720 1548 1641 1.0E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39605 20bdc2829859cf999e9c08b2e7943f51 2165 SUPERFAMILY SSF53901 33 407 1.08E-97 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 SUPERFAMILY SSF47831 29 140 2.62E-21 T 17-03-2017 IPR008731 Phosphotransferase system, enzyme I N-terminal GO:0009401 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 SUPERFAMILY SSF52009 123 241 1.83E-30 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 285 304 5.0E-18 T 17-03-2017 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 431 446 5.0E-18 T 17-03-2017 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 448 463 5.0E-18 T 17-03-2017 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 PRINTS PR01736 Phosphoenolpyruvate-protein phosphotransferase signature 484 496 5.0E-18 T 17-03-2017 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 Gene3D G3DSA:3.50.30.10 131 244 1.6E-33 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 ProSitePatterns PS00742 PEP-utilizing enzymes signature 2. 431 449 - T 17-03-2017 IPR023151 PEP-utilising enzyme, conserved site GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 Pfam PF02896 PEP-utilising enzyme, TIM barrel domain 253 524 2.0E-79 T 17-03-2017 IPR000121 PEP-utilising enzyme, C-terminal GO:0016310|GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 TIGRFAM TIGR01417 PTS_I_fam: phosphoenolpyruvate-protein phosphotransferase 5 545 2.8E-125 T 17-03-2017 IPR006318 Phosphotransferase system, enzyme I-like GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 PIRSF PIRSF000732 1 556 1.3E-170 T 17-03-2017 IPR024692 Phosphotransferase system, enzyme I GO:0008965|GO:0009401 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 ProSitePatterns PS00370 PEP-utilizing enzymes phosphorylation site signature. 181 192 - T 17-03-2017 IPR018274 PEP-utilising enzyme, active site GO:0016310|GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 Pfam PF00391 PEP-utilising enzyme, mobile domain 150 221 1.4E-21 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 Gene3D G3DSA:1.10.274.10 28 130 5.2E-21 T 17-03-2017 IPR008731 Phosphotransferase system, enzyme I N-terminal GO:0009401 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 Pfam PF05524 PEP-utilising enzyme, N-terminal 6 123 9.2E-22 T 17-03-2017 IPR008731 Phosphotransferase system, enzyme I N-terminal GO:0009401 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 SUPERFAMILY SSF51621 251 533 1.91E-84 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS43880 63f360575545691c7b6f02d7da0e5bff 556 Gene3D G3DSA:3.20.20.60 252 551 4.9E-88 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS41970 4ce80a01cfee0f25e7c29d06a9a09c3f 158 Pfam PF02627 Carboxymuconolactone decarboxylase family 23 96 6.1E-21 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS41970 4ce80a01cfee0f25e7c29d06a9a09c3f 158 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 31 80 2.1E-21 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS41970 4ce80a01cfee0f25e7c29d06a9a09c3f 158 SUPERFAMILY SSF69118 14 148 1.57E-39 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS41970 4ce80a01cfee0f25e7c29d06a9a09c3f 158 Gene3D G3DSA:1.20.1290.10 11 150 3.2E-46 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS07560 0090b512220ed11e1bb7272a954fb67d 362 SUPERFAMILY SSF53098 205 326 1.26E-5 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS07560 0090b512220ed11e1bb7272a954fb67d 362 Gene3D G3DSA:3.30.420.10 203 334 1.3E-5 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS07560 0090b512220ed11e1bb7272a954fb67d 362 Pfam PF13358 DDE superfamily endonuclease 176 319 6.5E-17 T 17-03-2017 SHXM_RS07560 0090b512220ed11e1bb7272a954fb67d 362 SUPERFAMILY SSF46689 22 137 9.86E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07560 0090b512220ed11e1bb7272a954fb67d 362 Gene3D G3DSA:1.10.10.60 36 92 1.3E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07560 0090b512220ed11e1bb7272a954fb67d 362 Pfam PF13551 Winged helix-turn helix 37 96 9.5E-16 T 17-03-2017 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 Pfam PF04055 Radical SAM superfamily 192 362 6.0E-19 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 181 477 2.5E-81 T 17-03-2017 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 Gene3D G3DSA:2.40.50.140 419 482 1.1E-14 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 Gene3D G3DSA:3.80.30.20 187 415 2.6E-60 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 190 210 - T 17-03-2017 IPR020612 Methylthiotransferase, conserved site GO:0051539 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 Hamap MF_01865 Ribosomal protein S12 methylthiotransferase RimO [rimO]. 5 480 60.596 T 17-03-2017 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 SUPERFAMILY SSF102114 176 408 4.32E-44 T 17-03-2017 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 Pfam PF00919 Uncharacterized protein family UPF0004 7 105 3.9E-31 T 17-03-2017 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 SMART SM00729 186 404 5.5E-40 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS37170 70292a9a3dd155e7e212d904c54c8211 498 TIGRFAM TIGR01125 TIGR01125: ribosomal protein S12 methylthiotransferase RimO 7 477 3.6E-118 T 17-03-2017 IPR005840 Ribosomal protein S12 methylthiotransferase RimO GO:0005737|GO:0016740|GO:0018339|GO:0051539 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SUPERFAMILY SSF55874 729 805 1.67E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SUPERFAMILY SSF55785 145 254 2.27E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 24 105 1.6E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Pfam PF01590 GAF domain 278 440 8.8E-7 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Gene3D G3DSA:3.30.450.20 145 254 1.4E-13 T 17-03-2017 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 498 688 6.5E-47 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SMART SM00331 468 688 1.7E-27 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Pfam PF08448 PAS fold 148 257 1.9E-17 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Pfam PF13581 Histidine kinase-like ATPase domain 701 797 1.6E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Gene3D G3DSA:3.30.450.20 21 116 2.1E-9 T 17-03-2017 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SUPERFAMILY SSF55781 379 449 1.09E-10 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Pfam PF13426 PAS domain 26 103 5.0E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SMART SM00065 274 450 0.0078 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 Gene3D G3DSA:3.30.450.40 266 446 6.8E-33 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SUPERFAMILY SSF81606 485 687 1.57E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS19595 0e679718bd47d5d1a1fa9769cd4bbfc3 817 SUPERFAMILY SSF55785 24 118 2.9E-10 T 17-03-2017 IPR000014 PAS domain SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 SUPERFAMILY SSF143968 318 483 1.44E-54 T 17-03-2017 SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 SUPERFAMILY SSF50475 3 317 9.02E-114 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 TIGRFAM TIGR03701 mena_SCO4490: menaquinone biosynthesis decarboxylase, SCO4490 family 8 440 3.2E-195 T 17-03-2017 IPR022390 4-hydroxybenzoate decarboxylase subunit C GO:0016831 SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 Pfam PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 11 423 4.5E-156 T 17-03-2017 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 Gene3D G3DSA:1.20.5.570 448 483 1.2E-5 T 17-03-2017 SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 TIGRFAM TIGR00148 TIGR00148: decarboxylase, UbiD family 6 448 5.1E-137 T 17-03-2017 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 SHXM_RS30635 eae64b330f879c861138804dc2f35b54 483 Gene3D G3DSA:3.40.1670.10 332 446 4.2E-38 T 17-03-2017 SHXM_RS29910 32affe3836c081548c6b26de6faa1847 538 Pfam PF01565 FAD binding domain 103 236 8.2E-27 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS29910 32affe3836c081548c6b26de6faa1847 538 Gene3D G3DSA:3.30.465.10 159 267 6.6E-10 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS29910 32affe3836c081548c6b26de6faa1847 538 Pfam PF08031 Berberine and berberine like 495 537 3.1E-11 T 17-03-2017 IPR012951 Berberine/berberine-like GO:0016491|GO:0050660|GO:0055114 SHXM_RS29910 32affe3836c081548c6b26de6faa1847 538 Gene3D G3DSA:3.30.43.10 86 154 2.5E-8 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS29910 32affe3836c081548c6b26de6faa1847 538 SUPERFAMILY SSF56176 75 267 4.25E-49 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS00520 429f2c01aa8ec81eeef5f74c15469373 265 Pfam PF00378 Enoyl-CoA hydratase/isomerase 20 260 2.4E-46 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS00520 429f2c01aa8ec81eeef5f74c15469373 265 SUPERFAMILY SSF52096 20 264 4.24E-66 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS00520 429f2c01aa8ec81eeef5f74c15469373 265 Gene3D G3DSA:3.90.226.10 20 263 1.5E-63 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 Pfam PF00005 ABC transporter 21 175 8.4E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 Gene3D G3DSA:3.40.50.300 2 246 7.0E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 SMART SM00382 30 232 5.5E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 SUPERFAMILY SSF55021 253 331 5.61E-17 T 17-03-2017 SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 Gene3D G3DSA:3.30.70.260 254 331 3.0E-21 T 17-03-2017 SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 SMART SM00930 257 332 1.4E-19 T 17-03-2017 IPR018449 NIL domain SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 SUPERFAMILY SSF52540 2 245 7.02E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12820 177c4e32394054e159d37353e1dc3ee5 351 Pfam PF09383 NIL domain 259 331 1.2E-17 T 17-03-2017 IPR018449 NIL domain SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 Pfam PF02811 PHP domain 7 193 7.5E-44 T 17-03-2017 IPR004013 PHP domain GO:0003824 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 5 1058 0.0 T 17-03-2017 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 Gene3D G3DSA:2.40.50.140 1014 1092 8.5E-5 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 Pfam PF01336 OB-fold nucleic acid binding domain 1021 1095 7.5E-7 T 17-03-2017 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 315 754 1.2E-159 T 17-03-2017 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 Gene3D G3DSA:3.20.20.140 6 267 2.4E-39 T 17-03-2017 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 SMART SM00481 6 73 3.5E-29 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 SUPERFAMILY SSF89550 6 247 5.62E-30 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS05415 0e923406a26cd5cbf1e848dafbdfa201 1176 Pfam PF14579 Helix-hairpin-helix motif 828 916 1.3E-24 T 17-03-2017 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS43435 2cf335395f0b28644eb782694f5db0a6 310 Gene3D G3DSA:1.10.287.70 36 155 2.0E-9 T 17-03-2017 SHXM_RS43435 2cf335395f0b28644eb782694f5db0a6 310 SUPERFAMILY SSF81324 41 163 4.32E-11 T 17-03-2017 SHXM_RS43435 2cf335395f0b28644eb782694f5db0a6 310 Pfam PF07885 Ion channel 70 152 9.3E-10 T 17-03-2017 IPR013099 Potassium channel domain SHXM_RS16785 64aeb1e60ac752c04729c94a78d4a655 69 Pfam PF04149 Domain of unknown function (DUF397) 10 64 5.0E-24 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 ProSitePatterns PS00622 LuxR-type HTH domain signature. 177 204 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 Gene3D G3DSA:3.40.50.2300 12 162 1.9E-34 T 17-03-2017 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 Pfam PF00072 Response regulator receiver domain 15 126 3.4E-22 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 SUPERFAMILY SSF52172 12 142 1.29E-28 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 SUPERFAMILY SSF46894 154 219 2.48E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 Pfam PF00196 Bacterial regulatory proteins, luxR family 163 217 6.4E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 193 205 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 163 177 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 177 193 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 SMART SM00448 13 126 5.9E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 Gene3D G3DSA:1.10.10.10 163 220 4.8E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49940 87fed889659b8fa5096c166e39f2103e 229 SMART SM00421 160 217 3.8E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 SUPERFAMILY SSF53850 92 298 1.4E-38 T 17-03-2017 SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 Gene3D G3DSA:3.40.190.10 181 270 3.4E-23 T 17-03-2017 SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 Gene3D G3DSA:1.10.10.10 1 88 6.5E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 Gene3D G3DSA:3.40.190.10 91 180 1.1E-18 T 17-03-2017 SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 63 1.6E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 Pfam PF03466 LysR substrate binding domain 89 295 1.5E-41 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS44035 483a092ee93526256c667b0934e5f1bf 302 SUPERFAMILY SSF46785 1 112 2.25E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.30.365.10 656 795 1.8E-55 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.30.365.10 380 482 1.8E-55 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 175 740 2.0E-144 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.90.1170.50 19 132 4.9E-42 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.30.365.10 197 301 4.6E-30 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 TIGRFAM TIGR03196 pucD: xanthine dehydrogenase D subunit 24 795 4.9E-241 T 17-03-2017 IPR017609 Xanthine dehydrogenase D subunit KEGG: 00230+1.17.1.4|MetaCyc: PWY-5497|MetaCyc: PWY-5695|MetaCyc: PWY-6538|MetaCyc: PWY-6596|MetaCyc: PWY-6606|MetaCyc: PWY-6607|MetaCyc: PWY-6608|MetaCyc: PWY-6999 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.30.365.10 133 196 1.4E-41 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.30.365.10 304 378 1.4E-41 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 SUPERFAMILY SSF56003 136 795 1.57E-148 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Gene3D G3DSA:3.30.365.10 483 614 2.1E-26 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 38 144 7.7E-32 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 SUPERFAMILY SSF54665 21 164 1.44E-42 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS38865 4338aacb1c5dd182df91caa68e313704 798 SMART SM01008 38 144 7.6E-48 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS40595 cba373947d56a5b82aff34ffc896ab03 207 SUPERFAMILY SSF46689 5 66 2.79E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS40595 cba373947d56a5b82aff34ffc896ab03 207 SUPERFAMILY SSF48498 78 189 4.55E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS40595 cba373947d56a5b82aff34ffc896ab03 207 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 2.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS40595 cba373947d56a5b82aff34ffc896ab03 207 Gene3D G3DSA:1.10.357.10 6 195 2.6E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS40595 cba373947d56a5b82aff34ffc896ab03 207 Pfam PF13977 Bacterial transcriptional repressor 78 192 3.3E-8 T 17-03-2017 SHXM_RS40595 cba373947d56a5b82aff34ffc896ab03 207 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 53 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF55048 691 756 3.01E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF50129 1427 1545 3.46E-26 T 17-03-2017 IPR011032 GroES-like SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF00698 Acyl transferase domain 566 884 6.0E-71 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 283 6.0E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1433 1488 1.7E-4 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1728 1908 8.7E-58 T 17-03-2017 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.40.50.720 1547 1640 1.8E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.40.50.720 1728 1930 8.3E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF51735 1728 1927 2.93E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM00829 1413 1718 6.8E-180 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM00823 Phosphopantetheine attachment site 2012 2084 3.8E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2039 2054 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM00826 933 1102 2.2E-79 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.90.180.10 1428 1546 1.5E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF08659 KR domain 1728 1906 3.2E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 567 864 2.1E-102 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:1.10.1200.10 2011 2083 3.1E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF52151 565 692 1.12E-60 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF52151 757 855 1.12E-60 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF53901 31 405 5.27E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 291 408 1.7E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM01294 2013 2080 3.6E-5 T 17-03-2017 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 196 212 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.40.47.10 36 295 2.1E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF51735 1221 1393 1.3E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.40.366.10 755 859 7.2E-65 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.40.366.10 565 686 7.2E-65 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.40.47.10 297 461 1.2E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF51735 1511 1647 3.59E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF08990 Erythronolide synthase docking 2 25 3.0E-8 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 411 511 1.0E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF14765 Polyketide synthase dehydratase 933 1213 1.4E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF13602 Zinc-binding dehydrogenase 1591 1718 7.4E-19 T 17-03-2017 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Gene3D G3DSA:3.30.70.250 691 754 6.5E-10 T 17-03-2017 SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SMART SM00825 Beta-ketoacyl synthase 36 461 6.6E-215 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 SUPERFAMILY SSF47336 2005 2083 4.58E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39610 91f5560c3221c01b280fea0ca656df5b 2164 Pfam PF00550 Phosphopantetheine attachment site 2015 2080 6.9E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 SMART SM00939 335 560 8.8E-53 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 351 552 7.7E-33 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 Gene3D G3DSA:2.60.120.260 364 564 9.6E-63 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 SUPERFAMILY SSF53474 41 370 2.92E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 SUPERFAMILY SSF49785 364 564 2.08E-46 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 58 564 7.8E-89 T 17-03-2017 IPR005674 CocE/Serine esterase GO:0016787 SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 Gene3D G3DSA:3.40.50.1820 262 363 5.4E-68 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 Gene3D G3DSA:3.40.50.1820 36 190 5.4E-68 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04470 123b7eef91f26c0875f6c0c797bd6457 568 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 61 320 1.5E-52 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS00335 2fe4e823da894c6c7cd3a49454307d5f 425 Gene3D G3DSA:3.40.50.1100 165 415 1.3E-41 T 17-03-2017 SHXM_RS00335 2fe4e823da894c6c7cd3a49454307d5f 425 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 92 387 4.3E-57 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS00335 2fe4e823da894c6c7cd3a49454307d5f 425 SUPERFAMILY SSF53686 70 404 9.69E-65 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS00335 2fe4e823da894c6c7cd3a49454307d5f 425 Gene3D G3DSA:3.40.50.1100 108 164 5.4E-4 T 17-03-2017 SHXM_RS19305 c357abf82e0c4dfe11bae5cee4d1534b 219 Pfam PF13309 HTH domain 156 217 1.1E-18 T 17-03-2017 SHXM_RS19305 c357abf82e0c4dfe11bae5cee4d1534b 219 ProDom PD037769 DNA-BINDING YHEO UNCHARACTERIZED BACTERIA SIMILAR HI0575 CONTAINING TRANSCRIPTION REGULATOR HELIX-TURN-HELIX 18 138 4.0E-42 T 17-03-2017 IPR013559 YheO-like SHXM_RS19305 c357abf82e0c4dfe11bae5cee4d1534b 219 Pfam PF08348 YheO-like PAS domain 19 127 1.9E-30 T 17-03-2017 IPR013559 YheO-like SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 Pfam PF01804 Penicillin amidase 63 909 7.9E-246 T 17-03-2017 IPR002692 Penicillin/cephalosporin acylase GO:0016787|GO:0017000 SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 Gene3D G3DSA:3.60.20.10 487 693 1.7E-116 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 Gene3D G3DSA:3.60.20.10 310 391 1.7E-116 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 Gene3D G3DSA:3.60.20.10 741 759 1.7E-116 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 Gene3D G3DSA:2.30.120.10 392 478 5.4E-26 T 17-03-2017 SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 Gene3D G3DSA:1.10.439.10 47 224 4.3E-62 T 17-03-2017 IPR023343 Penicillin amidase type, domain1 GO:0016811 SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 PIRSF PIRSF001227 20 920 9.1E-270 T 17-03-2017 IPR014395 Penicillin acylase GO:0016811 SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 SUPERFAMILY SSF56235 298 710 9.0E-216 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 SUPERFAMILY SSF56235 737 920 9.0E-216 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32420 44e74e409480f2c97e23d6b94ed6c6bf 920 SUPERFAMILY SSF56235 59 254 9.0E-216 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 Gene3D G3DSA:1.10.630.10 20 409 1.4E-130 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 SUPERFAMILY SSF48264 21 409 3.93E-100 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 196 218 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 141 157 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 300 327 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 95 106 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 158 173 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 282 293 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 328 343 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 349 358 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 PRINTS PR00359 B-class P450 signature 358 369 1.5E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07360 f98a1c35e166e96079e94737c17c1f32 409 Pfam PF00067 Cytochrome P450 281 379 6.7E-19 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 Pfam PF12833 Helix-turn-helix domain 36 115 8.8E-25 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 SUPERFAMILY SSF46689 66 117 3.4E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 SUPERFAMILY SSF46689 13 64 4.19E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 67 109 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 Gene3D G3DSA:1.10.10.60 68 116 3.2E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 Gene3D G3DSA:1.10.10.60 12 67 8.1E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 SMART SM00342 30 113 5.4E-34 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 97 113 5.6E-7 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS30255 04a393a1cd39ce51175a55c0a91cf6a4 168 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 82 97 5.6E-7 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS48255 6fc58e53a373103a677af4c6ad079b4e 443 Gene3D G3DSA:1.20.1250.20 24 206 6.6E-32 T 17-03-2017 SHXM_RS48255 6fc58e53a373103a677af4c6ad079b4e 443 SUPERFAMILY SSF103473 14 417 1.44E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS48255 6fc58e53a373103a677af4c6ad079b4e 443 Pfam PF07690 Major Facilitator Superfamily 36 380 3.6E-42 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS48255 6fc58e53a373103a677af4c6ad079b4e 443 Gene3D G3DSA:1.20.1250.20 228 413 1.6E-16 T 17-03-2017 SHXM_RS40280 88b8b867c280a583e8fd7c44bdbaef26 132 Gene3D G3DSA:2.60.120.10 3 124 1.8E-30 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS40280 88b8b867c280a583e8fd7c44bdbaef26 132 SUPERFAMILY SSF51182 7 118 2.72E-21 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS40280 88b8b867c280a583e8fd7c44bdbaef26 132 Pfam PF07883 Cupin domain 18 83 9.6E-15 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 205 210 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 Pfam PF02983 Alpha-lytic protease prodomain 105 157 1.3E-12 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 Gene3D G3DSA:2.40.10.10 178 261 8.6E-27 T 17-03-2017 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 Gene3D G3DSA:2.40.10.10 262 352 8.1E-30 T 17-03-2017 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 Gene3D G3DSA:3.30.300.50 105 171 5.6E-6 T 17-03-2017 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 SUPERFAMILY SSF50494 180 359 7.91E-38 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 Gene3D G3DSA:3.30.300.50 50 103 1.7E-4 T 17-03-2017 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 266 286 3.4E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 330 344 3.4E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 287 304 3.4E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 203 217 3.4E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 306 329 3.4E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 Pfam PF00089 Trypsin 201 357 2.4E-10 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 315 326 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS03600 d808ae685c8d2eb50b398da34edf6d9a 443 PIRSF PIRSF001134 1 366 2.3E-112 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS38975 ae7dc49cbf0d95d98dcbc54ba1ecccfe 202 Gene3D G3DSA:3.90.550.10 10 201 1.3E-35 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS38975 ae7dc49cbf0d95d98dcbc54ba1ecccfe 202 Pfam PF12804 MobA-like NTP transferase domain 13 175 3.9E-37 T 17-03-2017 IPR025877 MobA-like NTP transferase SHXM_RS38975 ae7dc49cbf0d95d98dcbc54ba1ecccfe 202 SUPERFAMILY SSF53448 11 198 2.25E-33 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 Gene3D G3DSA:3.30.1390.10 56 129 3.9E-31 T 17-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 ProDom PD001326 RIBOSOMAL L7/L12 50S RIBONUCLEOPROTEIN CHLOROPLAST L12 PLASTID DIRECT SEQUENCING PEPTIDE 64 129 3.0E-20 T 17-03-2017 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 Pfam PF16320 Ribosomal protein L7/L12 dimerisation domain 7 53 1.0E-17 T 17-03-2017 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 Hamap MF_00368 50S ribosomal protein L7/L12 [rplL]. 3 129 22.696 T 17-03-2017 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 TIGRFAM TIGR00855 L12: ribosomal protein bL12 1 129 2.3E-46 T 17-03-2017 IPR000206 Ribosomal protein L7/L12 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 SUPERFAMILY SSF48300 5 65 2.49E-14 T 17-03-2017 IPR008932 Ribosomal protein L7/L12, oligomerisation GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 Gene3D G3DSA:1.20.5.710 3 53 3.7E-19 T 17-03-2017 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 Pfam PF00542 Ribosomal protein L7/L12 C-terminal domain 63 129 6.3E-28 T 17-03-2017 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31105 c24ea1f1445afa7bf73fa90935e7ed8c 129 SUPERFAMILY SSF54736 58 129 1.92E-22 T 17-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SHXM_RS20360 45ca37365b38c271ba24d471ad0a327d 323 SMART SM00418 250 321 7.3E-4 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS20360 45ca37365b38c271ba24d471ad0a327d 323 SUPERFAMILY SSF46785 250 317 8.73E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20360 45ca37365b38c271ba24d471ad0a327d 323 Gene3D G3DSA:1.10.10.10 253 312 2.9E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20360 45ca37365b38c271ba24d471ad0a327d 323 Pfam PF01022 Bacterial regulatory protein, arsR family 261 297 1.6E-4 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 SUPERFAMILY SSF159127 1 81 2.35E-23 T 17-03-2017 SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 Pfam PF01455 HupF/HypC family 1 69 2.1E-25 T 17-03-2017 IPR001109 Hydrogenase expression/formation protein, HupF/HypC SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 TIGRFAM TIGR00074 hypC_hupF: hydrogenase assembly chaperone HypC/HupF 1 78 3.2E-21 T 17-03-2017 IPR001109 Hydrogenase expression/formation protein, HupF/HypC SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 ProSitePatterns PS01097 Hydrogenases expression/synthesis hupF/hypC family signature. 1 9 - T 17-03-2017 IPR019812 Hydrogenase assembly chaperone, conserved site SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 60 72 8.3E-13 T 17-03-2017 IPR001109 Hydrogenase expression/formation protein, HupF/HypC SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 21 37 8.3E-13 T 17-03-2017 IPR001109 Hydrogenase expression/formation protein, HupF/HypC SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 2 9 8.3E-13 T 17-03-2017 IPR001109 Hydrogenase expression/formation protein, HupF/HypC SHXM_RS43475 b19787ec87e3ec1d47e60445f201ee6c 99 PRINTS PR00445 HupF/HypC hydrogenase expression/synthesis family signature 42 58 8.3E-13 T 17-03-2017 IPR001109 Hydrogenase expression/formation protein, HupF/HypC SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.50.720 4 253 4.6E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Pfam PF08659 KR domain 1518 1709 5.7E-12 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF53901 635 839 5.6E-54 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.50.720 1487 1522 7.0E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.50.720 1560 1744 7.0E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.47.10 680 839 1.4E-40 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.10.129.10 1824 1910 4.1E-4 T 17-03-2017 IPR029069 HotDog domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1488 1711 1.2E-7 T 17-03-2017 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.47.10 393 679 6.1E-41 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.47.10 902 973 9.0E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Gene3D G3DSA:3.40.47.10 1005 1113 9.0E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Pfam PF14765 Polyketide synthase dehydratase 1826 2088 4.8E-10 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 584 666 1.2E-22 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 906 1067 1.2E-11 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF53901 393 674 1.88E-38 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF51735 1566 1757 3.24E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF51735 1486 1530 3.24E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 675 786 3.0E-25 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SMART SM00825 Beta-ketoacyl synthase 393 842 1.1E-33 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF51735 7 253 4.55E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 251 5.7E-51 T 17-03-2017 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 1.9E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 1.9E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.9E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 1.9E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 1.9E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF53901 1009 1109 9.06E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03065 5e963c49447d7b55e886d3ddf46474b5 2106 SUPERFAMILY SSF53901 859 977 9.06E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 SUPERFAMILY SSF50494 13 269 2.12E-58 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 Gene3D G3DSA:2.40.10.10 74 138 5.4E-14 T 17-03-2017 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 Gene3D G3DSA:2.40.10.10 139 270 8.9E-37 T 17-03-2017 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 Pfam PF00089 Trypsin 35 270 1.3E-48 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 78 83 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 Gene3D G3DSA:2.40.10.10 35 73 1.2E-12 T 17-03-2017 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 225 237 3.2E-11 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 68 83 3.2E-11 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 131 145 3.2E-11 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 226 237 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS37470 ab6c9570ef5895cd7f072f2bbc739a59 275 SMART SM00020 34 271 3.1E-60 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 SUPERFAMILY SSF46785 177 234 8.2E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 SUPERFAMILY SSF54909 247 322 1.79E-7 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Pfam PF13404 AsnC-type helix-turn-helix domain 16 52 9.3E-9 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Pfam PF13404 AsnC-type helix-turn-helix domain 188 225 4.0E-9 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 SMART SM00344 188 289 1.0E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Gene3D G3DSA:3.30.70.920 248 322 6.3E-10 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Gene3D G3DSA:3.30.70.920 75 146 2.2E-4 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Gene3D G3DSA:1.10.10.10 15 54 4.9E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Gene3D G3DSA:1.10.10.10 188 230 4.4E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 Pfam PF01037 Lrp/AsnC ligand binding domain 251 319 3.4E-6 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 184 200 4.2E-5 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 211 230 4.2E-5 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS39410 49b33418eae323849fbf096b1585a844 329 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 200 211 4.2E-5 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS23900 9ba11d9c4ef820721e773b52e9e1c7f0 195 Gene3D G3DSA:3.30.530.20 60 191 1.7E-13 T 17-03-2017 IPR023393 START-like domain SHXM_RS23900 9ba11d9c4ef820721e773b52e9e1c7f0 195 SUPERFAMILY SSF55961 60 189 2.87E-20 T 17-03-2017 SHXM_RS23900 9ba11d9c4ef820721e773b52e9e1c7f0 195 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 60 164 5.1E-12 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 910 924 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Pfam PF00656 Caspase domain 20 152 3.8E-5 T 17-03-2017 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SUPERFAMILY SSF52540 285 485 6.54E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SUPERFAMILY SSF50978 791 1119 1.01E-35 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 1290 1304 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 1265 1303 340.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 785 832 70.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 1221 1259 5.3 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 1081 1119 0.0025 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 884 923 0.0019 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 984 1022 13.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SMART SM00320 929 980 26.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SUPERFAMILY SSF69322 1237 1421 6.54E-25 T 17-03-2017 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 SUPERFAMILY SSF69322 1091 1166 6.54E-25 T 17-03-2017 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Gene3D G3DSA:2.130.10.10 1205 1421 7.0E-23 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Gene3D G3DSA:2.130.10.10 1106 1129 7.0E-23 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Gene3D G3DSA:2.130.10.10 790 1105 3.6E-36 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Gene3D G3DSA:3.40.50.300 279 329 4.0E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Pfam PF00400 WD domain, G-beta repeat 899 923 2.2E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40790 dac3dca08c1b314cdbe4d475f8b32480 1517 Pfam PF00400 WD domain, G-beta repeat 1092 1118 0.025 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 SUPERFAMILY SSF52172 2 139 2.13E-18 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 SMART SM00448 1 120 3.9E-6 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 Gene3D G3DSA:3.40.50.2300 2 151 6.6E-24 T 17-03-2017 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 150 164 1.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 164 180 1.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 192 1.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 Gene3D G3DSA:1.10.10.10 152 211 3.0E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 Pfam PF00072 Response regulator receiver domain 4 108 3.8E-15 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 SUPERFAMILY SSF46894 135 194 4.42E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 SMART SM00421 147 210 1.4E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20995 49757aac3e3026c7e079dd082c335506 214 Pfam PF00196 Bacterial regulatory proteins, luxR family 149 193 3.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25105 dd277b3baef85ae443b9dc2fbdd177fa 126 TIGRFAM TIGR02970 succ_dehyd_cytB: succinate dehydrogenase, cytochrome b556 subunit 6 111 2.5E-29 T 17-03-2017 IPR014314 Succinate dehydrogenase, cytochrome b556 subunit GO:0000104|GO:0006099|GO:0045281 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25105 dd277b3baef85ae443b9dc2fbdd177fa 126 SUPERFAMILY SSF81343 2 113 9.81E-28 T 17-03-2017 SHXM_RS25105 dd277b3baef85ae443b9dc2fbdd177fa 126 Gene3D G3DSA:1.20.1300.10 3 114 2.2E-30 T 17-03-2017 SHXM_RS25105 dd277b3baef85ae443b9dc2fbdd177fa 126 Pfam PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 5 108 1.2E-23 T 17-03-2017 IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit GO:0016627 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Gene3D G3DSA:3.30.43.10 6 103 1.7E-13 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 SUPERFAMILY SSF46548 515 636 6.8E-17 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Gene3D G3DSA:1.10.1060.10 519 636 2.3E-16 T 17-03-2017 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Pfam PF13534 4Fe-4S dicluster domain 553 625 6.0E-8 T 17-03-2017 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Pfam PF02913 FAD linked oxidases, C-terminal domain 282 528 4.8E-50 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Gene3D G3DSA:1.10.45.10 490 518 5.9E-8 T 17-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 SUPERFAMILY SSF55103 254 530 1.64E-50 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 SUPERFAMILY SSF56176 30 279 9.35E-51 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Pfam PF01565 FAD binding domain 55 191 7.8E-32 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 554 565 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Gene3D G3DSA:3.30.465.10 111 279 1.3E-19 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS50275 eaed3959edc6f46b976aa816f42a85ee 956 Pfam PF02754 Cysteine-rich domain 856 935 0.095 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS09605 719e07b664bb0e37514f720d5436d7f8 684 Pfam PF00589 Phage integrase family 351 542 1.7E-20 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS09605 719e07b664bb0e37514f720d5436d7f8 684 SUPERFAMILY SSF56349 356 552 1.38E-25 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS09605 719e07b664bb0e37514f720d5436d7f8 684 Gene3D G3DSA:1.10.443.10 352 547 7.2E-27 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Pfam PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster 40 132 4.9E-21 T 17-03-2017 IPR028261 Dihydroprymidine dehydrogenase domain II Reactome: R-HSA-73621 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 SUPERFAMILY SSF46548 5 155 3.77E-35 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Gene3D G3DSA:3.40.50.720 149 234 1.0E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Gene3D G3DSA:3.40.50.720 414 492 1.0E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 PRINTS PR00419 Adrenodoxin reductase family signature 169 182 1.2E-22 T 17-03-2017 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 PRINTS PR00419 Adrenodoxin reductase family signature 211 221 1.2E-22 T 17-03-2017 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 PRINTS PR00419 Adrenodoxin reductase family signature 285 299 1.2E-22 T 17-03-2017 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 PRINTS PR00419 Adrenodoxin reductase family signature 146 168 1.2E-22 T 17-03-2017 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 400 470 2.7E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 146 319 1.2E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Gene3D G3DSA:1.10.1060.10 2 148 3.3E-37 T 17-03-2017 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 TIGRFAM TIGR01317 GOGAT_sm_gam: glutamate synthase, NADH/NADPH, small subunit 3 488 1.0E-192 T 17-03-2017 IPR006005 Glutamate synthase, NADH/NADPH, small subunit 1 GO:0006537|GO:0016639|GO:0055114 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 Gene3D G3DSA:3.50.50.60 235 413 1.2E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44980 f411bda61935ef646407366a5bdcfcdf 500 SUPERFAMILY SSF51971 144 414 3.71E-59 T 17-03-2017 SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 SMART SM00895 89 214 1.2E-14 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 Gene3D G3DSA:1.20.120.530 84 223 4.2E-24 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 SUPERFAMILY SSF46785 13 104 2.08E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 SUPERFAMILY SSF48008 85 221 4.45E-24 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 Gene3D G3DSA:1.10.10.10 12 79 2.9E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 SMART SM00345 21 79 4.1E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 Pfam PF07729 FCD domain 89 210 6.2E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS32110 61445d48fc568fbeb34f88bddcf8db93 237 Pfam PF00392 Bacterial regulatory proteins, gntR family 18 79 9.2E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS18185 d2abc5de8c50a2264771642d1cc0c47d 259 SUPERFAMILY SSF46689 2 51 1.61E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS18185 d2abc5de8c50a2264771642d1cc0c47d 259 Gene3D G3DSA:1.10.10.60 6 51 2.3E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS18185 d2abc5de8c50a2264771642d1cc0c47d 259 PRINTS PR00379 Intein signature 70 82 2.0E-5 T 17-03-2017 IPR006142 Intein GO:0016539 SHXM_RS18185 d2abc5de8c50a2264771642d1cc0c47d 259 PRINTS PR00379 Intein signature 171 183 2.0E-5 T 17-03-2017 IPR006142 Intein GO:0016539 SHXM_RS18185 d2abc5de8c50a2264771642d1cc0c47d 259 SUPERFAMILY SSF55608 168 232 9.72E-5 T 17-03-2017 IPR027434 Homing endonuclease GO:0004519 SHXM_RS18185 d2abc5de8c50a2264771642d1cc0c47d 259 Gene3D G3DSA:3.10.28.10 169 248 0.001 T 17-03-2017 IPR027434 Homing endonuclease GO:0004519 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.47.10 35 298 3.7E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF00698 Acyl transferase domain 568 887 1.5E-91 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF00698 Acyl transferase domain 2139 2462 4.5E-64 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.366.10 568 689 6.1E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.366.10 759 868 6.1E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF08659 KR domain 1215 1392 9.0E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF08659 KR domain 3013 3191 2.4E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF47336 1495 1616 4.97E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00826 2512 2678 3.1E-82 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3327 3342 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00823 Phosphopantetheine attachment site 1500 1572 1.6E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00823 Phosphopantetheine attachment site 3300 3372 9.8E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1859 1976 1.9E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 411 2.5E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00825 Beta-ketoacyl synthase 1603 2029 4.1E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00825 Beta-ketoacyl synthase 35 464 1.1E-219 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:1.10.1200.10 3298 3372 4.6E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:1.10.1200.10 1498 1571 3.5E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF53901 30 154 1.05E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF53901 182 409 1.05E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3013 3193 1.4E-62 T 17-03-2017 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1215 1394 6.2E-58 T 17-03-2017 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF51735 3012 3257 6.52E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF47336 3294 3377 1.7E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.47.10 1599 1863 5.0E-96 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM01294 3301 3368 1.5E-5 T 17-03-2017 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM01294 1501 1568 5.4E-7 T 17-03-2017 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF52151 2332 2428 1.2E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF52151 2136 2268 1.2E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF52151 760 858 1.12E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF52151 567 695 1.12E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.47.10 1864 2029 5.1E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.47.10 299 465 9.9E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF51735 2799 2996 4.72E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF55048 694 759 2.22E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF55048 2267 2331 4.58E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF51735 985 1200 1.71E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.30.70.250 2267 2330 1.6E-7 T 17-03-2017 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.30.70.250 694 758 4.0E-8 T 17-03-2017 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1527 1542 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF14765 Polyketide synthase dehydratase 2512 2787 1.0E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF00550 Phosphopantetheine attachment site 1502 1568 2.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF00550 Phosphopantetheine attachment site 3303 3368 6.6E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1764 1780 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF08990 Erythronolide synthase docking 2 24 2.0E-11 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF53901 1596 1973 5.3E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 33 286 1.6E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1601 1851 1.2E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.50.720 3013 3218 2.5E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.50.720 1215 1396 7.4E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SUPERFAMILY SSF51735 1213 1442 1.32E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.366.10 2331 2446 1.3E-85 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Gene3D G3DSA:3.40.366.10 2131 2262 1.3E-85 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 530 9.0E-17 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1981 2103 1.1E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2140 2444 8.1E-132 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45375 384464288bf7156bfb70b73e25bbff89 3454 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 570 868 3.8E-124 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 SUPERFAMILY SSF46689 199 250 1.06E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 201 245 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 Pfam PF12852 Cupin 2 184 5.3E-35 T 17-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 Pfam PF12833 Helix-turn-helix domain 222 300 6.6E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 Gene3D G3DSA:1.10.10.60 254 302 2.4E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 SMART SM00342 216 299 3.3E-29 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 Gene3D G3DSA:1.10.10.60 197 253 4.4E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 SUPERFAMILY SSF46689 252 301 9.41E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42265 2142806019f017f89b6a60934aa4015f 315 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 253 295 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS37770 ba85f88ac207774ea915dd62d0ea18d1 361 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 65 227 2.3E-15 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS37770 ba85f88ac207774ea915dd62d0ea18d1 361 SUPERFAMILY SSF53901 9 229 4.76E-29 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37770 ba85f88ac207774ea915dd62d0ea18d1 361 SUPERFAMILY SSF53901 207 358 4.43E-8 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37770 ba85f88ac207774ea915dd62d0ea18d1 361 Gene3D G3DSA:3.40.47.10 9 234 3.7E-22 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42280 0439cab419149150652c01705dc11403 304 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 235 250 9.8E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS42280 0439cab419149150652c01705dc11403 304 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 250 266 9.8E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS42280 0439cab419149150652c01705dc11403 304 SMART SM00342 183 266 1.4E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS42280 0439cab419149150652c01705dc11403 304 Gene3D G3DSA:1.10.10.60 221 269 6.6E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42280 0439cab419149150652c01705dc11403 304 Pfam PF12833 Helix-turn-helix domain 190 267 1.6E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS42280 0439cab419149150652c01705dc11403 304 Gene3D G3DSA:1.10.10.60 173 220 1.5E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42280 0439cab419149150652c01705dc11403 304 Pfam PF02311 AraC-like ligand binding domain 29 141 8.3E-9 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS42280 0439cab419149150652c01705dc11403 304 SUPERFAMILY SSF46689 219 269 2.64E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42280 0439cab419149150652c01705dc11403 304 SUPERFAMILY SSF51215 6 160 2.75E-18 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS42280 0439cab419149150652c01705dc11403 304 Gene3D G3DSA:2.60.120.280 14 160 4.5E-20 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS42280 0439cab419149150652c01705dc11403 304 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 220 262 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 ProSitePatterns PS00393 Phosphoenolpyruvate carboxylase active site 2. 555 567 - T 17-03-2017 IPR033129 Phosphoenolpyruvate carboxylase, His active site KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 Gene3D G3DSA:1.20.1440.90 270 391 1.0E-22 T 17-03-2017 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 Hamap MF_00595 Phosphoenolpyruvate carboxylase [ppc]. 3 906 18.092 T 17-03-2017 IPR022805 Phosphoenolpyruvate carboxylase, bacterial/plant-type GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 176 192 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 553 573 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 732 758 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 127 140 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 234 249 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 595 624 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 PRINTS PR00150 Phosphoenolpyruvate carboxylase signature 389 409 4.1E-57 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 SUPERFAMILY SSF51621 13 906 7.69E-269 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 Pfam PF00311 Phosphoenolpyruvate carboxylase 123 906 6.1E-282 T 17-03-2017 IPR021135 Phosphoenolpyruvate carboxylase GO:0006099|GO:0008964|GO:0015977 KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS32780 03fbaafd93851f056b040b6e1c8f327e 906 ProSitePatterns PS00781 Phosphoenolpyruvate carboxylase active site 1. 128 139 - T 17-03-2017 IPR018129 Phosphoenolpyruvate carboxylase, Lys active site KEGG: 00620+4.1.1.31|KEGG: 00680+4.1.1.31|KEGG: 00710+4.1.1.31|KEGG: 00720+4.1.1.31|MetaCyc: PWY-1622|MetaCyc: PWY-241|MetaCyc: PWY-5913|MetaCyc: PWY-6142|MetaCyc: PWY-6146|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117|MetaCyc: PWY-7124 SHXM_RS20485 ccd3a186bfc35fc0bdae9a250f95e2e2 215 SUPERFAMILY SSF53254 3 197 2.51E-46 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS20485 ccd3a186bfc35fc0bdae9a250f95e2e2 215 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 196 2.2E-50 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS20485 ccd3a186bfc35fc0bdae9a250f95e2e2 215 SMART SM00855 3 157 1.6E-22 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS20485 ccd3a186bfc35fc0bdae9a250f95e2e2 215 Gene3D G3DSA:3.40.50.1240 3 198 1.1E-44 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 Gene3D G3DSA:3.40.640.10 78 322 5.2E-68 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 Pfam PF00202 Aminotransferase class-III 40 384 2.4E-80 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 Gene3D G3DSA:3.90.1150.10 323 387 5.3E-56 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 Gene3D G3DSA:3.90.1150.10 498 553 5.3E-56 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 SUPERFAMILY SSF53383 498 552 6.45E-9 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 SUPERFAMILY SSF53383 33 384 9.07E-100 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 257 294 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS37365 b7a4719ccb834268e54ea30c1631286c 581 TIGRFAM TIGR00709 dat: 2,4-diaminobutyrate 4-transaminase 24 383 1.7E-124 T 17-03-2017 IPR004637 2,4-diaminobutyrate 4-transaminase GO:0008483|GO:0009058 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 SHXM_RS48190 1428e6a2fc10c3cc2e572bd4cbc88019 323 Gene3D G3DSA:2.115.10.20 17 321 2.3E-87 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS48190 1428e6a2fc10c3cc2e572bd4cbc88019 323 SUPERFAMILY SSF75005 16 320 2.62E-77 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS48190 1428e6a2fc10c3cc2e572bd4cbc88019 323 Pfam PF04616 Glycosyl hydrolases family 43 38 320 8.0E-58 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS48190 1428e6a2fc10c3cc2e572bd4cbc88019 323 PIRSF PIRSF026534 2 323 1.9E-107 T 17-03-2017 IPR016840 Glycoside hydrolase, family 43, endo-1, 5-alpha-L-arabinosidase GO:0046558 SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 32 92 2.8E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 Pfam PF13602 Zinc-binding dehydrogenase 191 310 6.8E-25 T 17-03-2017 SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 SUPERFAMILY SSF51735 121 287 5.88E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 Gene3D G3DSA:3.90.180.10 4 153 9.4E-45 T 17-03-2017 IPR011032 GroES-like SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 SMART SM00829 14 323 1.6E-36 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 Gene3D G3DSA:3.40.50.720 154 243 2.9E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 SUPERFAMILY SSF50129 2 154 2.74E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS02685 3c8b94f1e857aa76c5827678674aa6fe 339 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 149 170 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS28395 4141388669def9f9f0864e7eff3fa85f 351 SUPERFAMILY SSF81324 32 158 5.5E-20 T 17-03-2017 SHXM_RS28395 4141388669def9f9f0864e7eff3fa85f 351 Pfam PF02254 TrkA-N domain 143 259 1.6E-27 T 17-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 SHXM_RS28395 4141388669def9f9f0864e7eff3fa85f 351 SUPERFAMILY SSF51735 138 277 3.66E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28395 4141388669def9f9f0864e7eff3fa85f 351 Pfam PF07885 Ion channel 40 121 1.4E-13 T 17-03-2017 IPR013099 Potassium channel domain SHXM_RS28395 4141388669def9f9f0864e7eff3fa85f 351 Gene3D G3DSA:1.10.287.70 38 132 2.2E-14 T 17-03-2017 SHXM_RS28395 4141388669def9f9f0864e7eff3fa85f 351 Gene3D G3DSA:3.40.50.720 135 272 3.6E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 Hamap MF_00452 Phosphoenolpyruvate carboxykinase [GTP] [pckG]. 8 624 51.929 T 17-03-2017 IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising GO:0004611|GO:0005525|GO:0006094 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 ProSitePatterns PS00505 Phosphoenolpyruvate carboxykinase (GTP) signature. 288 296 - T 17-03-2017 IPR018091 Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site GO:0004613 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 SUPERFAMILY SSF68923 8 245 1.62E-97 T 17-03-2017 IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 Gene3D G3DSA:3.90.228.20 246 333 2.1E-27 T 17-03-2017 IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 Gene3D G3DSA:3.90.228.20 350 623 3.4E-103 T 17-03-2017 IPR013035 Phosphoenolpyruvate carboxykinase, C-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 Gene3D G3DSA:3.40.449.10 9 245 5.9E-98 T 17-03-2017 IPR008210 Phosphoenolpyruvate carboxykinase, N-terminal GO:0004611|GO:0006094|GO:0017076 Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 SUPERFAMILY SSF53795 246 623 7.33E-155 T 17-03-2017 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 Pfam PF00821 Phosphoenolpyruvate carboxykinase 19 623 8.9E-277 T 17-03-2017 IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising GO:0004611|GO:0005525|GO:0006094 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 SHXM_RS33270 3a9ee08b6dda6f772c7090bb7800e57b 624 PIRSF PIRSF001348 2 624 1.8E-272 T 17-03-2017 IPR008209 Phosphoenolpyruvate carboxykinase, GTP-utilising GO:0004611|GO:0005525|GO:0006094 KEGG: 00010+4.1.1.32|KEGG: 00020+4.1.1.32|KEGG: 00620+4.1.1.32|MetaCyc: PWY-7383|Reactome: R-HSA-70263 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 Hamap MF_01365_B 50S ribosomal protein L6 [rplF]. 1 177 38.531 T 17-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 SUPERFAMILY SSF56053 1 83 2.09E-26 T 17-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 Gene3D G3DSA:3.90.930.12 84 178 2.6E-38 T 17-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 PIRSF PIRSF002162 1 178 1.9E-48 T 17-03-2017 IPR000702 Ribosomal protein L6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 PRINTS PR00059 Ribosomal protein L6 signature 72 97 5.9E-32 T 17-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 PRINTS PR00059 Ribosomal protein L6 signature 142 163 5.9E-32 T 17-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 PRINTS PR00059 Ribosomal protein L6 signature 100 116 5.9E-32 T 17-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 Pfam PF00347 Ribosomal protein L6 92 165 1.4E-20 T 17-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 Pfam PF00347 Ribosomal protein L6 11 83 3.9E-20 T 17-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 Gene3D G3DSA:3.90.930.12 2 83 6.8E-30 T 17-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 ProSitePatterns PS00525 Ribosomal protein L6 signature 1. 155 163 - T 17-03-2017 IPR002358 Ribosomal protein L6, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 TIGRFAM TIGR03654 L6_bact: ribosomal protein uL6 2 177 8.4E-74 T 17-03-2017 IPR019906 Ribosomal protein L6, bacterial-type GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS31245 dda96a0303c91225d481eb0fbacde006 179 SUPERFAMILY SSF56053 84 177 2.09E-35 T 17-03-2017 IPR020040 Ribosomal protein L6, alpha-beta domain GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS34325 1edbf78850b384387c2a1e1a4fd884d9 379 Pfam PF00899 ThiF family 122 356 2.1E-17 T 17-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SHXM_RS34325 1edbf78850b384387c2a1e1a4fd884d9 379 Gene3D G3DSA:3.40.50.720 122 189 6.9E-6 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34325 1edbf78850b384387c2a1e1a4fd884d9 379 SUPERFAMILY SSF69572 122 354 5.49E-12 T 17-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 Pfam PF05491 Holliday junction DNA helicase ruvB C-terminus 271 344 1.2E-28 T 17-03-2017 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 Gene3D G3DSA:1.10.8.60 201 273 9.8E-33 T 17-03-2017 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 Hamap MF_00016 Holliday junction ATP-dependent DNA helicase RuvB [ruvB]. 1 362 158.814 T 17-03-2017 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 Gene3D G3DSA:3.40.50.300 38 190 1.5E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 SUPERFAMILY SSF52540 38 268 9.32E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 Pfam PF05496 Holliday junction DNA helicase ruvB N-terminus 22 253 1.3E-107 T 17-03-2017 IPR008824 Holliday junction DNA helicase ruvB, N-terminal GO:0006281|GO:0006310|GO:0009378 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 SUPERFAMILY SSF46785 275 348 2.11E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 ProDom PD005323 DNA HELICASE HOLLIDAY JUNCTION RUVB NUCLEOTIDE-BINDING ATP-BINDING SOS RECOMBINATION RESPONSE 270 342 2.0E-20 T 17-03-2017 IPR008823 DNA helicase, Holliday junction RuvB type, C-terminal GO:0003677|GO:0006281|GO:0006310|GO:0009378 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 Gene3D G3DSA:1.10.10.10 275 345 5.4E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 TIGRFAM TIGR00635 ruvB: Holliday junction DNA helicase RuvB 42 344 6.7E-134 T 17-03-2017 IPR004605 DNA helicase, Holliday junction RuvB type GO:0003677|GO:0005524|GO:0006281|GO:0006310|GO:0009378 SHXM_RS12540 8f73a1d0318d2a9ceff045c322d0888c 362 SMART SM00382 69 202 4.6E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 SUPERFAMILY SSF52402 250 358 1.32E-10 T 17-03-2017 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 SUPERFAMILY SSF55874 673 830 1.06E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Pfam PF00512 His Kinase A (phospho-acceptor) domain 617 684 8.6E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Gene3D G3DSA:1.10.287.130 610 670 2.7E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Pfam PF00582 Universal stress protein family 249 363 1.0E-7 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Gene3D G3DSA:3.30.565.10 671 833 6.7E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Gene3D G3DSA:1.20.120.620 406 498 6.3E-16 T 17-03-2017 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 723 831 7.6E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 PRINTS PR00344 Bacterial sensor protein C-terminal signature 777 787 1.1E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 PRINTS PR00344 Bacterial sensor protein C-terminal signature 816 829 1.1E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 PRINTS PR00344 Bacterial sensor protein C-terminal signature 759 773 1.1E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 PRINTS PR00344 Bacterial sensor protein C-terminal signature 792 810 1.1E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 SUPERFAMILY SSF47384 607 684 2.94E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Gene3D G3DSA:3.40.50.300 19 228 1.4E-91 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Gene3D G3DSA:3.40.50.620 245 356 3.1E-13 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Pfam PF02702 Osmosensitive K+ channel His kinase sensor domain 21 229 1.8E-91 T 17-03-2017 IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal GO:0000155|GO:0000160|GO:0004673|GO:0016020 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 SMART SM00388 616 684 2.7E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 SMART SM00387 722 832 6.1E-30 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01640 2a2349ca8de6fb21ecd056affcff6868 872 Pfam PF13493 Domain of unknown function (DUF4118) 405 508 1.0E-19 T 17-03-2017 IPR025201 Sensor protein KdpD, transmembrane domain SHXM_RS06245 8013006023d462759f54f94b261993f5 484 SMART SM01350 186 476 2.8E-198 T 17-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 Gene3D G3DSA:3.40.50.720 5 187 5.0E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 365 387 4.9E-82 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 11 34 4.9E-82 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 175 203 4.9E-82 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 74 103 4.9E-82 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 257 284 4.9E-82 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 127 152 4.9E-82 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 Gene3D G3DSA:1.10.1040.10 188 442 9.6E-104 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 SUPERFAMILY SSF51735 11 184 2.43E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06245 8013006023d462759f54f94b261993f5 484 Gene3D G3DSA:1.20.5.320 444 479 4.2E-19 T 17-03-2017 IPR012284 6-phosphogluconate dehydrogenase, domain 3 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 ProSitePatterns PS00461 6-phosphogluconate dehydrogenase signature. 261 273 - T 17-03-2017 IPR006184 6-phosphogluconate-binding site GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 SUPERFAMILY SSF48179 184 477 4.2E-116 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 12 181 3.5E-50 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 Pfam PF00393 6-phosphogluconate dehydrogenase, C-terminal domain 186 475 2.3E-120 T 17-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 TIGRFAM TIGR00873 gnd: 6-phosphogluconate dehydrogenase (decarboxylating) 12 475 8.0E-204 T 17-03-2017 IPR006113 6-phosphogluconate dehydrogenase, decarboxylating GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS06245 8013006023d462759f54f94b261993f5 484 PIRSF PIRSF000109 5 484 5.0E-199 T 17-03-2017 IPR006113 6-phosphogluconate dehydrogenase, decarboxylating GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 269 285 4.6E-17 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 143 161 4.6E-17 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 10 29 4.6E-17 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 182 200 4.6E-17 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PIRSF PIRSF000350 1 478 1.2E-66 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 8 327 6.1E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 SUPERFAMILY SSF51905 1 347 3.74E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 368 474 5.0E-21 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 Gene3D G3DSA:3.50.50.60 7 149 1.9E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 Gene3D G3DSA:3.30.390.30 363 481 1.7E-27 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 SUPERFAMILY SSF55424 364 482 1.12E-26 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 364 385 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 41 56 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 270 284 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 314 321 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 182 207 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 430 445 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 9 31 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 146 155 3.6E-46 T 17-03-2017 SHXM_RS38800 0301ef303036e408da84caa4c55b934d 483 Gene3D G3DSA:3.50.50.60 150 341 1.3E-36 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 Pfam PF14759 Reductase C-terminal 327 396 1.6E-11 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 Gene3D G3DSA:3.30.390.30 327 396 5.1E-18 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 291 1.2E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 Gene3D G3DSA:3.50.50.60 234 318 6.4E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 Gene3D G3DSA:3.50.50.60 111 233 1.6E-41 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 SUPERFAMILY SSF51905 3 194 4.09E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 237 251 3.3E-16 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 276 283 3.3E-16 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 151 176 3.3E-16 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 3.3E-16 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 SUPERFAMILY SSF51905 150 314 2.52E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 Gene3D G3DSA:3.50.50.60 5 110 1.1E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 151 169 3.9E-22 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 236 252 3.9E-22 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 3.9E-22 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 107 125 3.9E-22 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 261 283 3.9E-22 T 17-03-2017 SHXM_RS43780 37e8085d42411df923f2ae4b867d789d 400 SUPERFAMILY SSF55424 320 395 1.92E-17 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS08935 6f78d71f8197cf7815a8f57b1a1b2dcb 152 Pfam PF13546 DDE superfamily endonuclease 31 147 1.2E-21 T 17-03-2017 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 Pfam PF03704 Bacterial transcriptional activator domain 105 247 9.6E-38 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 PRINTS PR00364 Disease resistance protein signature 507 521 3.7E-7 T 17-03-2017 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 PRINTS PR00364 Disease resistance protein signature 419 433 3.7E-7 T 17-03-2017 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 PRINTS PR00364 Disease resistance protein signature 341 356 3.7E-7 T 17-03-2017 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 SMART SM01043 105 247 1.8E-41 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 Pfam PF00486 Transcriptional regulatory protein, C terminal 27 84 1.1E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 SUPERFAMILY SSF52540 296 567 8.04E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 Gene3D G3DSA:3.40.50.300 337 434 2.2E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 Pfam PF00931 NB-ARC domain 340 527 4.5E-10 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 SUPERFAMILY SSF46894 6 84 1.25E-10 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 SUPERFAMILY SSF48452 102 264 9.49E-33 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 Gene3D G3DSA:1.25.40.10 136 226 2.7E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 SMART SM00862 17 98 2.4E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS28485 220c4856d2078a4f86e1adbf56284262 652 Gene3D G3DSA:1.10.10.10 27 84 6.0E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06420 e669a635bc8112d5f2e0c6d143926556 135 Gene3D G3DSA:1.10.1200.10 47 123 2.5E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06420 e669a635bc8112d5f2e0c6d143926556 135 SUPERFAMILY SSF47336 49 124 4.32E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06420 e669a635bc8112d5f2e0c6d143926556 135 SMART SM01294 56 120 4.4E-4 T 17-03-2017 SHXM_RS06420 e669a635bc8112d5f2e0c6d143926556 135 SMART SM00823 Phosphopantetheine attachment site 52 124 1.1E-8 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06420 e669a635bc8112d5f2e0c6d143926556 135 Pfam PF00550 Phosphopantetheine attachment site 57 120 4.2E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 291 3.1E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 SUPERFAMILY SSF52540 321 570 1.97E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 ProSitePatterns PS00211 ABC transporters family signature. 472 486 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 Gene3D G3DSA:1.10.3720.10 87 290 1.2E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 551 593 8.2E-6 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 27 73 7.6E-8 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 Pfam PF00005 ABC transporter 342 499 2.4E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 SMART SM00382 350 557 2.6E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 Gene3D G3DSA:3.40.50.300 320 573 9.9E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45730 8743436330144fb401ca2d2c98717856 598 SUPERFAMILY SSF161098 91 277 3.53E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04325 7ce23cb51f18b93fdf1a0488afb2b197 281 Pfam PF08241 Methyltransferase domain 70 167 5.7E-23 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS04325 7ce23cb51f18b93fdf1a0488afb2b197 281 SUPERFAMILY SSF53335 11 278 5.42E-56 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04325 7ce23cb51f18b93fdf1a0488afb2b197 281 Gene3D G3DSA:3.40.50.150 28 279 2.2E-56 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS21540 3e31bbbfc092583ad5fe635a3b9743f4 217 SMART SM00855 11 165 8.8E-22 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS21540 3e31bbbfc092583ad5fe635a3b9743f4 217 Gene3D G3DSA:3.40.50.1240 10 206 2.8E-56 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS21540 3e31bbbfc092583ad5fe635a3b9743f4 217 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 12 204 7.5E-55 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS21540 3e31bbbfc092583ad5fe635a3b9743f4 217 SUPERFAMILY SSF53254 10 210 4.57E-54 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS21540 3e31bbbfc092583ad5fe635a3b9743f4 217 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 14 23 - T 17-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 Pfam PF01120 Alpha-L-fucosidase 107 468 2.9E-32 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 SUPERFAMILY SSF51445 394 471 3.27E-80 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 SUPERFAMILY SSF51445 276 360 3.27E-80 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 SUPERFAMILY SSF51445 64 219 3.27E-80 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 Gene3D G3DSA:3.20.20.80 279 364 9.4E-101 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 Gene3D G3DSA:3.20.20.80 398 472 9.4E-101 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 Gene3D G3DSA:3.20.20.80 60 222 9.4E-101 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS21875 e432cdc73b7c24057c56f3fc3961f756 568 SMART SM00812 71 506 2.0E-13 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS42580 00e19fe78694ba9c2fe518605e5e56c9 506 Pfam PF00884 Sulfatase 49 383 1.7E-59 T 17-03-2017 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SHXM_RS42580 00e19fe78694ba9c2fe518605e5e56c9 506 ProSitePatterns PS00523 Sulfatases signature 1. 88 100 - T 17-03-2017 IPR024607 Sulfatase, conserved site SHXM_RS42580 00e19fe78694ba9c2fe518605e5e56c9 506 PIRSF PIRSF036666 7 504 7.2E-93 T 17-03-2017 IPR012251 N-acetylglucosamine-6-sulfatase GO:0008449|GO:0030203 KEGG: 00531+3.1.6.14|Reactome: R-HSA-2022857|Reactome: R-HSA-2206305|Reactome: R-HSA-432720 SHXM_RS42580 00e19fe78694ba9c2fe518605e5e56c9 506 Gene3D G3DSA:3.40.720.10 46 402 1.9E-91 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS42580 00e19fe78694ba9c2fe518605e5e56c9 506 Gene3D G3DSA:3.30.1120.10 435 496 8.1E-6 T 17-03-2017 SHXM_RS42580 00e19fe78694ba9c2fe518605e5e56c9 506 SUPERFAMILY SSF53649 47 493 1.0E-106 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS49160 27ef9b3524d2580862f6887012fbdd85 455 Gene3D G3DSA:3.40.190.10 35 151 3.8E-18 T 17-03-2017 SHXM_RS49160 27ef9b3524d2580862f6887012fbdd85 455 Gene3D G3DSA:3.40.190.10 152 348 1.1E-21 T 17-03-2017 SHXM_RS49160 27ef9b3524d2580862f6887012fbdd85 455 Pfam PF13416 Bacterial extracellular solute-binding protein 59 348 6.6E-25 T 17-03-2017 SHXM_RS49160 27ef9b3524d2580862f6887012fbdd85 455 Pfam PF10518 TAT (twin-arginine translocation) pathway signal sequence 6 29 2.8E-5 T 17-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SHXM_RS49160 27ef9b3524d2580862f6887012fbdd85 455 SUPERFAMILY SSF53850 25 435 1.75E-54 T 17-03-2017 SHXM_RS48010 9fbccb60709abbb34259e84413fc7df2 283 Gene3D G3DSA:1.10.3720.10 6 270 2.9E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48010 9fbccb60709abbb34259e84413fc7df2 283 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 97 276 2.0E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48010 9fbccb60709abbb34259e84413fc7df2 283 SUPERFAMILY SSF161098 9 283 2.35E-72 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 247 1.9E-62 T 17-03-2017 SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 SUPERFAMILY SSF51735 8 248 9.71E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 5.1E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 5.1E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 5.1E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 5.1E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.1E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 5.1E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 2.2E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 2.2E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 2.2E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32605 99883290af4f2c8f523613d1ef391fbe 266 Gene3D G3DSA:3.40.50.720 3 248 7.0E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 Gene3D G3DSA:1.10.10.60 238 285 3.2E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 Gene3D G3DSA:2.60.120.280 40 110 4.4E-7 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 SMART SM00342 199 283 7.4E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 SUPERFAMILY SSF46689 239 285 1.03E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 SUPERFAMILY SSF51182 40 109 1.6E-6 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 Pfam PF02311 AraC-like ligand binding domain 29 126 1.8E-8 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS42890 4eeb676d489b3ad8d70e28b7d2aeee62 294 Pfam PF12833 Helix-turn-helix domain 206 284 1.5E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 ProSitePatterns PS00211 ABC transporters family signature. 483 497 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Gene3D G3DSA:3.40.50.300 344 572 2.3E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 SUPERFAMILY SSF49879 13 90 4.4E-22 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 SUPERFAMILY SSF49879 254 350 1.61E-22 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 SUPERFAMILY SSF52540 342 579 3.45E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Pfam PF01061 ABC-2 type transporter 636 845 9.2E-17 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 SMART SM00382 373 567 1.4E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Gene3D G3DSA:2.60.200.20 18 91 8.8E-23 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Gene3D G3DSA:2.60.200.20 249 333 4.7E-21 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Pfam PF00005 ABC transporter 364 511 1.4E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 SMART SM00240 24 74 3.6E-10 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 SMART SM00240 261 312 1.7E-14 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Pfam PF00498 FHA domain 263 323 4.2E-15 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS17265 8ded3c7b42da6e83fa5a7c6db0c1bc1e 914 Pfam PF00498 FHA domain 25 88 1.4E-15 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Hamap MF_00802 Glutamate-ammonia-ligase adenylyltransferase [glnE]. 103 1071 16.974 T 17-03-2017 IPR023057 Glutamate-ammonia-ligase adenylyltransferase GO:0008882 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 SUPERFAMILY SSF81593 356 505 2.59E-39 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase 765 914 3.6E-35 T 17-03-2017 IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain GO:0008882 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase 609 692 1.0E-4 T 17-03-2017 IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain GO:0008882 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Pfam PF03710 Glutamate-ammonia ligase adenylyltransferase 107 341 4.4E-51 T 17-03-2017 IPR005190 Glutamate-ammonia ligase adenylyltransferase, repeated domain GO:0008882 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Gene3D G3DSA:3.30.460.10 191 351 3.7E-56 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Gene3D G3DSA:3.30.460.10 767 924 4.5E-50 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 SUPERFAMILY SSF81301 88 350 1.01E-68 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 SUPERFAMILY SSF81301 581 692 4.9E-13 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 SUPERFAMILY SSF81301 766 924 3.07E-43 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 SUPERFAMILY SSF81593 930 1081 4.39E-36 T 17-03-2017 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Pfam PF08335 GlnD PII-uridylyltransferase 364 504 3.3E-37 T 17-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 SHXM_RS19340 792cbb0a5c22e11a3bef5065770630f6 1085 Pfam PF08335 GlnD PII-uridylyltransferase 938 1080 1.1E-20 T 17-03-2017 IPR013546 PII-uridylyltransferase/Glutamine-synthetase adenylyltransferase GO:0016779 SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 SUPERFAMILY SSF88659 119 173 3.18E-7 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 172 2.1E-14 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 Gene3D G3DSA:1.10.1740.10 11 107 2.5E-14 T 17-03-2017 SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 Pfam PF04542 Sigma-70 region 2 28 94 2.4E-9 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 Pfam PF08281 Sigma-70, region 4 126 171 5.1E-6 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 Gene3D G3DSA:1.10.10.10 126 173 4.9E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25490 6b5793b31b7c442d15158516df6eb031 192 SUPERFAMILY SSF88946 10 98 1.41E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.50.720 4805 5000 7.3E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 2751 2950 6.3E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 6880 6896 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 1476 1690 2.8E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.30.70.250 2522 2582 2.1E-5 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.30.70.250 7373 7433 3.9E-6 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.30.70.250 5837 5897 4.0E-6 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.30.70.250 691 751 3.7E-6 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.30.70.250 4003 4063 8.8E-7 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 8147 8361 5.34E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF47336 1756 1878 1.01E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF53901 5177 5553 1.05E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF53901 1862 2237 1.03E-97 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 5706 5832 8.6E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 4064 4178 9.6E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 5898 6007 8.6E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 7244 7368 1.4E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 752 864 3.3E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 3874 3998 9.6E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 7434 7547 1.4E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 2583 2695 1.8E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 2393 2517 1.8E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.366.10 562 686 3.3E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF47336 6617 6732 2.49E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3605 3722 2.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 5439 5556 1.8E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 2.6E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 6975 7092 4.7E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2123 2240 2.8E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00698 Acyl transferase domain 7249 7562 5.1E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00698 Acyl transferase domain 567 880 1.3E-57 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00698 Acyl transferase domain 3879 4193 4.2E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00698 Acyl transferase domain 5713 6023 2.0E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00698 Acyl transferase domain 2398 2710 1.3E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 1391 1427 3.23E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 1203 1358 3.23E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2028 2044 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00012 Phosphopantetheine attachment site. 8470 8485 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8149 8329 1.1E-57 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1478 1658 2.9E-63 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4806 4986 1.4E-59 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6333 6512 2.8E-64 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2964 3143 2.2E-62 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 5344 5360 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF55048 5837 5898 6.93E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 7911 8117 2.48E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 2962 3192 2.91E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 5711 5832 3.4E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 5891 6002 3.4E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 3877 3998 1.36E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 4057 4160 1.36E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 7247 7368 1.05E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 7427 7530 1.05E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF14765 Polyketide synthase dehydratase 928 1194 2.2E-52 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF14765 Polyketide synthase dehydratase 4248 4525 1.5E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF14765 Polyketide synthase dehydratase 7610 7899 6.1E-47 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 6719 6979 2.9E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 3349 3609 9.0E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 1866 2127 1.7E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF53901 6714 7091 4.14E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00823 Phosphopantetheine attachment site 3253 3325 2.7E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00823 Phosphopantetheine attachment site 1763 1835 3.4E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00823 Phosphopantetheine attachment site 8443 8515 4.7E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00823 Phosphopantetheine attachment site 6622 6694 4.3E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00823 Phosphopantetheine attachment site 5088 5160 1.1E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5115 5130 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 32 297 9.4E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 5178 5443 9.7E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 4531 4595 3.54E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 4633 4791 3.54E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00826 928 1091 4.5E-84 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00826 7610 7796 5.0E-72 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00826 4248 4412 2.7E-81 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM01294 3254 3321 4.3E-8 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM01294 8444 8511 3.6E-8 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM01294 5089 5156 7.0E-6 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM01294 6623 6690 3.5E-7 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM01294 1764 1831 5.8E-6 T 17-03-2017 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2243 2363 9.4E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 5559 5676 3.2E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3725 3834 8.0E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 7095 7210 7.0E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 532 2.0E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.50.720 8148 8341 1.4E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.50.720 2963 3181 4.9E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.50.720 1477 1660 1.8E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.50.720 6334 6549 1.1E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF47336 8441 8522 1.14E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3280 3295 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 6120 6319 1.12E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 298 464 2.1E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 3610 3775 3.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 6980 7145 1.2E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 2128 2292 9.1E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:3.40.47.10 5444 5609 8.3E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF55048 2522 2583 1.06E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 198 214 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3510 3526 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 565 686 4.71E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 745 857 4.71E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6649 6664 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 6334 6557 1.2E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF51735 4802 5041 3.03E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00550 Phosphopantetheine attachment site 3255 3321 5.2E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00550 Phosphopantetheine attachment site 1765 1831 1.9E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00550 Phosphopantetheine attachment site 6624 6690 9.4E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00550 Phosphopantetheine attachment site 5090 5156 7.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00550 Phosphopantetheine attachment site 8445 8511 5.3E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 2576 2687 7.85E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF52151 2396 2517 7.85E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF55048 691 752 8.37E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF55048 4003 4064 6.15E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF08659 KR domain 8149 8328 7.3E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF08659 KR domain 4806 4984 1.7E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF08659 KR domain 6333 6511 1.1E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF08659 KR domain 1478 1656 1.5E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF08659 KR domain 2964 3141 4.2E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF55048 7373 7434 3.4E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:1.10.1200.10 6620 6694 2.9E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:1.10.1200.10 1760 1835 4.8E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:1.10.1200.10 8442 8516 3.5E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:1.10.1200.10 3249 3325 9.1E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Gene3D G3DSA:1.10.1200.10 5086 5160 6.5E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF47336 3248 3362 9.81E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2399 2691 9.0E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3880 4174 4.3E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 568 860 4.4E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5714 6006 6.2E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 7250 7543 9.5E-130 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF53901 32 407 2.51E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF47336 5083 5196 1.96E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SUPERFAMILY SSF53901 3344 3720 1.72E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00825 Beta-ketoacyl synthase 1866 2293 1.4E-209 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00825 Beta-ketoacyl synthase 3349 3775 1.0E-225 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00825 Beta-ketoacyl synthase 5183 5609 4.4E-231 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00825 Beta-ketoacyl synthase 37 463 5.5E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 SMART SM00825 Beta-ketoacyl synthase 6719 7145 9.7E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3347 3597 2.7E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5181 5431 1.1E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1864 2115 2.4E-85 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 5.6E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6717 6967 9.4E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22170 ee34ec9c918148e627f942892f60d514 8607 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1790 1805 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 Pfam PF02540 NAD synthase 309 556 2.3E-68 T 17-03-2017 IPR022310 NAD/GMP synthase SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 TIGRFAM TIGR00552 nadE: NAD+ synthetase 316 559 5.4E-56 T 17-03-2017 IPR003694 NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.1.5|Reactome: R-HSA-196807 SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 SUPERFAMILY SSF52402 306 564 7.45E-72 T 17-03-2017 SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 Gene3D G3DSA:3.40.50.620 306 564 5.1E-71 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 PIRSF PIRSF006630 1 584 1.5E-211 T 17-03-2017 IPR014445 Glutamine-dependent NAD(+) synthetase GO:0003952|GO:0005524|GO:0009435 KEGG: 00760+6.3.5.1|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: R-HSA-196807 SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 Gene3D G3DSA:3.60.110.10 3 258 7.3E-52 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 SUPERFAMILY SSF56317 3 279 2.88E-53 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 Pfam PF00795 Carbon-nitrogen hydrolase 5 258 3.9E-21 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS19360 1bfb8dec8c12ead7c329110db9c7d63f 584 ProSitePatterns PS00920 Nitrilases / cyanide hydratase signature 1. 36 51 - T 17-03-2017 IPR000132 Nitrilase/cyanide hydratase, conserved site GO:0016810 SHXM_RS13660 e3784c00ca84d6cf682c2ee51bef20b8 369 SUPERFAMILY SSF51679 5 357 2.22E-87 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13660 e3784c00ca84d6cf682c2ee51bef20b8 369 TIGRFAM TIGR04021 LLM_DMSO2_sfnG: dimethyl sulfone monooxygenase SfnG 6 359 1.4E-188 T 17-03-2017 IPR024014 Dimethyl sulphone monooxygenase SfnG SHXM_RS13660 e3784c00ca84d6cf682c2ee51bef20b8 369 Pfam PF00296 Luciferase-like monooxygenase 7 330 3.6E-73 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13660 e3784c00ca84d6cf682c2ee51bef20b8 369 Gene3D G3DSA:3.20.20.30 2 357 3.8E-96 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 78 7.4E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 SMART SM00895 88 212 9.4E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 Gene3D G3DSA:1.20.120.530 82 216 2.6E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 SUPERFAMILY SSF48008 85 217 1.2E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 SUPERFAMILY SSF46785 15 82 2.63E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 Gene3D G3DSA:1.10.10.10 13 79 1.2E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 SMART SM00345 20 78 2.4E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44730 d08035c4c5dea483e694a06687de7cea 228 Pfam PF07729 FCD domain 90 210 5.1E-26 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF00698 Acyl transferase domain 1260 1550 2.5E-33 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF47336 1742 1844 3.74E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF55048 1390 1455 1.44E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.40.50.720 2159 2193 1.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.40.50.720 2238 2417 1.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.40.47.10 972 1134 5.5E-51 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF03060 Nitronate monooxygenase 300 579 1.7E-9 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF03060 Nitronate monooxygenase 112 224 2.8E-8 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF00550 Phosphopantetheine attachment site 1750 1812 6.6E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF53901 689 812 3.69E-75 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF53901 1113 1127 3.69E-75 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF53901 855 1080 3.69E-75 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF51412 21 252 8.55E-15 T 17-03-2017 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF51735 2159 2201 9.2E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF51735 2237 2424 9.2E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1095 1173 3.8E-7 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF08659 KR domain 2161 2382 5.3E-35 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.40.47.10 693 971 1.5E-72 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF51735 1893 2031 3.48E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:1.10.1200.10 1745 1827 5.3E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF52151 1457 1557 2.14E-50 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF52151 1257 1386 2.14E-50 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1261 1564 2.6E-29 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.40.366.10 1456 1562 9.0E-52 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.40.366.10 1254 1380 9.0E-52 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Gene3D G3DSA:3.30.70.250 1388 1455 8.8E-12 T 17-03-2017 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 967 1084 2.8E-36 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SMART SM00825 Beta-ketoacyl synthase 693 1137 1.2E-112 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF51412 489 576 3.43E-12 T 17-03-2017 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SUPERFAMILY SSF51412 297 443 3.43E-12 T 17-03-2017 SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 692 959 3.9E-67 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04290 daadc957785e43c9cfb03269916a1576 2437 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2160 2384 4.3E-29 T 17-03-2017 SHXM_RS19125 d51d99487b575dcd33aea0cc5c8a84d6 212 PIRSF PIRSF006324 1 210 4.1E-52 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS19125 d51d99487b575dcd33aea0cc5c8a84d6 212 Pfam PF01810 LysE type translocator 17 207 3.8E-26 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 Gene3D G3DSA:1.10.510.10 141 289 2.0E-41 T 17-03-2017 SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 Pfam PF00069 Protein kinase domain 43 289 1.1E-41 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 SMART SM00220 43 289 5.8E-39 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 161 173 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 Gene3D G3DSA:3.30.200.20 37 140 1.8E-13 T 17-03-2017 SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 SUPERFAMILY SSF56112 41 289 2.29E-64 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS13895 cf19be10c376cd0fced75c808520ce19 292 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 49 71 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS05640 7a1d46e67bffd3897cdc6ceaf293636c 251 Gene3D G3DSA:3.40.50.1820 4 249 1.1E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS05640 7a1d46e67bffd3897cdc6ceaf293636c 251 Pfam PF01738 Dienelactone hydrolase family 19 250 6.0E-49 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS05640 7a1d46e67bffd3897cdc6ceaf293636c 251 SUPERFAMILY SSF53474 7 251 8.53E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS24420 7091e60c0291f783ba03b5ccf0c11463 508 Gene3D G3DSA:1.10.275.10 20 212 1.0E-35 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS24420 7091e60c0291f783ba03b5ccf0c11463 508 SUPERFAMILY SSF48557 21 504 9.42E-112 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS24420 7091e60c0291f783ba03b5ccf0c11463 508 Gene3D G3DSA:1.20.200.10 213 504 4.1E-74 T 17-03-2017 SHXM_RS24420 7091e60c0291f783ba03b5ccf0c11463 508 Pfam PF00221 Aromatic amino acid lyase 31 463 3.0E-116 T 17-03-2017 IPR001106 Aromatic amino acid lyase Reactome: R-HSA-70921 SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 Gene3D G3DSA:2.160.20.10 34 347 1.1E-28 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 Pfam PF13229 Right handed beta helix region 102 241 2.7E-14 T 17-03-2017 SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 Pfam PF13229 Right handed beta helix region 246 348 1.6E-5 T 17-03-2017 SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 SUPERFAMILY SSF51126 33 349 5.46E-39 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 SMART SM00710 195 216 260.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 SMART SM00710 281 308 330.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 SMART SM00710 162 184 200.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 SMART SM00710 245 280 1700.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14565 bf55449631d1c3163d7d3e24bbe4a5cb 358 SMART SM00710 217 238 9.4 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 SUPERFAMILY SSF48264 33 408 1.31E-78 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 Gene3D G3DSA:1.10.630.10 9 419 5.0E-103 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 Pfam PF00067 Cytochrome P450 225 391 9.0E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 167 182 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 150 166 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 295 306 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 213 235 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 371 382 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 312 339 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 104 115 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 340 355 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06425 f7ebb8147880e05c9b85b40ce90d0394 419 PRINTS PR00359 B-class P450 signature 362 371 3.0E-40 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 360 534 2.4E-51 T 17-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 70 115 1.8E-14 T 17-03-2017 IPR011096 FTP domain SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 SUPERFAMILY SSF49785 635 742 1.36E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Gene3D G3DSA:3.10.170.10 209 361 1.9E-44 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Gene3D G3DSA:2.60.120.260 662 742 1.0E-15 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 SUPERFAMILY SSF55486 209 535 6.78E-78 T 17-03-2017 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 348 364 6.3E-16 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 436 452 6.3E-16 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 369 380 6.3E-16 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 312 332 6.3E-16 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 210 356 4.3E-47 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Pfam PF01483 Proprotein convertase P-domain 662 742 3.8E-19 T 17-03-2017 IPR002884 Proprotein convertase, P GO:0004252|GO:0006508 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Gene3D G3DSA:2.60.40.10 543 625 6.7E-9 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 SUPERFAMILY SSF49313 543 625 1.4E-11 T 17-03-2017 IPR015919 Cadherin-like GO:0005509|GO:0016020 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Gene3D G3DSA:1.10.390.10 362 534 1.5E-50 T 17-03-2017 SHXM_RS35800 818d1ff0f4258d1a1b2d4ad05ce7a87f 742 Pfam PF05345 Putative Ig domain 575 613 2.3E-11 T 17-03-2017 IPR008009 Putative Ig SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Gene3D G3DSA:3.40.109.10 303 498 3.3E-38 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 TIGRFAM TIGR03553 F420_FbiB_CTERM: F420 biosynthesis protein FbiB, C-terminal domain 308 501 2.9E-94 T 17-03-2017 IPR019943 Coenzyme F420 biosynthesis protein FbiB, C-terminal GO:0016881 KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 SUPERFAMILY SSF144010 24 230 7.45E-65 T 17-03-2017 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Gene3D G3DSA:3.90.1660.10 80 140 5.2E-24 T 17-03-2017 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Gene3D G3DSA:3.30.1330.100 22 74 4.8E-55 T 17-03-2017 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Gene3D G3DSA:3.30.1330.100 141 229 4.8E-55 T 17-03-2017 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Pfam PF00881 Nitroreductase family 313 480 1.3E-26 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 SUPERFAMILY SSF55469 306 499 2.49E-37 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Hamap MF_01259 Coenzyme F420:L-glutamate ligase [fbiB]. 27 501 50.042 T 17-03-2017 IPR023661 Coenzyme F420:L-glutamate ligase, bacteria GO:0043773|GO:0046872|GO:0051188 KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Pfam PF01996 F420-0:Gamma-glutamyl ligase 100 226 1.0E-33 T 17-03-2017 IPR002847 Coenzyme F420:L-glutamate ligase-like domain KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 Pfam PF01996 F420-0:Gamma-glutamyl ligase 30 90 2.0E-9 T 17-03-2017 IPR002847 Coenzyme F420:L-glutamate ligase-like domain KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 SHXM_RS24230 37b9e4ac2b498f2ea3890c2de1812324 501 TIGRFAM TIGR01916 F420_cofE: coenzyme F420-0:L-glutamate ligase 23 231 8.4E-73 T 17-03-2017 IPR008225 Coenzyme F420:L-glutamate ligase GO:0043773|GO:0046872|GO:0051188 KEGG: 00680+6.3.2.31+6.3.2.34|MetaCyc: PWY-5199 SHXM_RS21865 7a16ce8669c25a98409aab61f1448efa 324 Pfam PF03405 Fatty acid desaturase 17 312 1.2E-76 T 17-03-2017 IPR005067 Fatty acid desaturase, type 2 GO:0006631|GO:0045300|GO:0055114 SHXM_RS21865 7a16ce8669c25a98409aab61f1448efa 324 PIRSF PIRSF000346 2 323 5.1E-111 T 17-03-2017 IPR005067 Fatty acid desaturase, type 2 GO:0006631|GO:0045300|GO:0055114 SHXM_RS21865 7a16ce8669c25a98409aab61f1448efa 324 Gene3D G3DSA:1.10.620.20 11 312 2.0E-109 T 17-03-2017 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: R-HSA-499943 SHXM_RS21865 7a16ce8669c25a98409aab61f1448efa 324 SUPERFAMILY SSF47240 13 318 1.19E-83 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS38905 c848fd38f99bd7ff243a9caa919343e7 380 Gene3D G3DSA:1.20.58.340 310 380 2.8E-24 T 17-03-2017 SHXM_RS38905 c848fd38f99bd7ff243a9caa919343e7 380 Gene3D G3DSA:3.30.460.20 36 176 1.1E-39 T 17-03-2017 SHXM_RS38905 c848fd38f99bd7ff243a9caa919343e7 380 Pfam PF01544 CorA-like Mg2+ transporter protein 75 376 6.8E-61 T 17-03-2017 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 SHXM_RS38905 c848fd38f99bd7ff243a9caa919343e7 380 SUPERFAMILY SSF143865 42 297 6.41E-62 T 17-03-2017 SHXM_RS38905 c848fd38f99bd7ff243a9caa919343e7 380 Gene3D G3DSA:1.20.58.340 177 284 6.8E-37 T 17-03-2017 SHXM_RS38905 c848fd38f99bd7ff243a9caa919343e7 380 SUPERFAMILY SSF144083 315 377 3.01E-19 T 17-03-2017 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Gene3D G3DSA:2.60.40.1120 649 730 1.8E-14 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 SUPERFAMILY SSF49452 644 728 1.51E-14 T 17-03-2017 IPR013784 Carbohydrate-binding-like fold GO:0030246 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 SUPERFAMILY SSF49464 734 801 4.32E-10 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Pfam PF13620 Carboxypeptidase regulatory-like domain 567 634 4.5E-10 T 17-03-2017 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Pfam PF13620 Carboxypeptidase regulatory-like domain 734 801 1.2E-10 T 17-03-2017 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Pfam PF13620 Carboxypeptidase regulatory-like domain 650 728 6.1E-16 T 17-03-2017 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 SUPERFAMILY SSF103473 31 218 1.31E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 SUPERFAMILY SSF103473 264 480 1.31E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Gene3D G3DSA:1.20.1250.20 279 481 4.4E-19 T 17-03-2017 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 SUPERFAMILY SSF49464 567 644 2.75E-10 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Gene3D G3DSA:1.20.1250.20 32 209 2.0E-28 T 17-03-2017 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Pfam PF07690 Major Facilitator Superfamily 34 426 2.1E-40 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Gene3D G3DSA:2.60.40.1120 567 644 2.7E-7 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS34980 70cb6de157877f20b9f86410ad3cf5ed 818 Gene3D G3DSA:2.60.40.1120 733 815 1.3E-10 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS11915 593add6486dc9c193c21ad8252999b93 257 Pfam PF04101 Glycosyltransferase family 28 C-terminal domain 142 230 4.3E-8 T 17-03-2017 IPR007235 Glycosyl transferase, family 28, C-terminal GO:0016758 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-5633231 SHXM_RS11915 593add6486dc9c193c21ad8252999b93 257 SUPERFAMILY SSF53756 13 254 1.0E-42 T 17-03-2017 SHXM_RS11915 593add6486dc9c193c21ad8252999b93 257 Gene3D G3DSA:3.40.50.2000 84 237 2.8E-22 T 17-03-2017 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 SUPERFAMILY SSF52016 643 902 4.71E-85 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 ProSitePatterns PS01244 Aconitase family signature 2. 505 518 - T 17-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 270 283 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 284 297 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 363 377 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 141 154 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 165 173 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 443 454 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 194 207 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 208 223 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 PRINTS PR00415 Aconitase family signature 505 518 3.4E-42 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Pfam PF00330 Aconitase family (aconitate hydratase) 64 574 1.5E-182 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 SUPERFAMILY SSF53732 4 639 1.7E-221 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Gene3D G3DSA:3.30.499.10 28 240 6.4E-79 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Gene3D G3DSA:3.40.1060.10 241 358 3.1E-36 T 17-03-2017 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Gene3D G3DSA:3.20.19.10 649 902 3.7E-77 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 ProSitePatterns PS00450 Aconitase family signature 1. 439 455 - T 17-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Pfam PF00694 Aconitase C-terminal domain 704 833 2.8E-44 T 17-03-2017 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 TIGRFAM TIGR01341 aconitase_1: aconitate hydratase 1 26 902 0.0 T 17-03-2017 IPR006249 Aconitase/Iron-responsive element-binding protein 2 KEGG: 00020+4.2.1.3|KEGG: 00630+4.2.1.3|KEGG: 00720+4.2.1.3 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Gene3D G3DSA:3.30.499.10 359 384 4.3E-65 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS38115 0a1aca03db33b6a9617415baff32edab 905 Gene3D G3DSA:3.30.499.10 431 587 4.3E-65 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 Gene3D G3DSA:2.40.33.10 73 166 1.2E-30 T 17-03-2017 IPR015806 Pyruvate kinase, beta-barrel insert domain GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 TIGRFAM TIGR01064 pyruv_kin: pyruvate kinase 2 469 1.1E-166 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 SUPERFAMILY SSF52935 320 470 6.28E-39 T 17-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 Gene3D G3DSA:3.40.1380.20 324 469 6.5E-43 T 17-03-2017 IPR015794 Pyruvate kinase, alpha/beta GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 Pfam PF02887 Pyruvate kinase, alpha/beta domain 356 468 9.6E-29 T 17-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 241 265 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 291 309 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 266 290 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 214 240 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 184 198 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 310 326 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 PRINTS PR01050 Pyruvate kinase family signature 59 75 6.7E-63 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 SUPERFAMILY SSF50800 71 164 8.9E-27 T 17-03-2017 IPR011037 Pyruvate kinase-like, insert domain SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 SUPERFAMILY SSF51621 1 74 8.03E-99 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 SUPERFAMILY SSF51621 154 336 8.03E-99 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 ProSitePatterns PS00110 Pyruvate kinase active site signature. 212 224 - T 17-03-2017 IPR018209 Pyruvate kinase, active site GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 Pfam PF00224 Pyruvate kinase, barrel domain 1 338 1.1E-128 T 17-03-2017 IPR015793 Pyruvate kinase, barrel GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 Gene3D G3DSA:3.20.20.60 167 323 9.8E-105 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS35520 adccf17c569ae8b30ecc8675dd23ca97 475 Gene3D G3DSA:3.20.20.60 2 72 9.8E-105 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 SUPERFAMILY SSF46785 25 169 3.91E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 95 110 7.1E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 114 130 7.1E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 78 94 7.1E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 144 164 7.1E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 Gene3D G3DSA:1.10.10.10 20 171 3.0E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 SMART SM00347 51 154 7.7E-21 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 ProSitePatterns PS00519 AsnC-type HTH domain signature. 79 105 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS29840 33ccd1080f00dd7302b7d3ef92b6581e 183 Pfam PF12802 MarR family 56 115 1.1E-11 T 17-03-2017 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SMART SM01043 103 248 1.8E-54 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SUPERFAMILY SSF52540 280 511 7.47E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Gene3D G3DSA:1.10.10.10 15 99 3.5E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SMART SM00028 823 856 0.0038 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SMART SM00028 783 816 41.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SMART SM00028 743 776 59.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SMART SM00028 863 896 73.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SUPERFAMILY SSF48452 787 897 2.66E-17 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Pfam PF00486 Transcriptional regulatory protein, C terminal 26 89 1.3E-11 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Pfam PF00931 NB-ARC domain 318 499 1.1E-12 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 PRINTS PR00364 Disease resistance protein signature 318 333 2.3E-10 T 17-03-2017 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 PRINTS PR00364 Disease resistance protein signature 397 411 2.3E-10 T 17-03-2017 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 PRINTS PR00364 Disease resistance protein signature 482 496 2.3E-10 T 17-03-2017 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Pfam PF03704 Bacterial transcriptional activator domain 103 248 1.5E-48 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SMART SM00862 14 96 3.9E-13 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SUPERFAMILY SSF46894 2 89 1.56E-12 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Gene3D G3DSA:1.25.40.10 688 711 5.5E-24 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Gene3D G3DSA:1.25.40.10 745 904 5.5E-24 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Gene3D G3DSA:1.25.40.10 106 224 5.5E-24 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Gene3D G3DSA:3.40.50.300 320 432 3.2E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SUPERFAMILY SSF48452 98 269 1.26E-39 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 Pfam PF13424 Tetratricopeptide repeat 785 854 5.4E-13 T 17-03-2017 SHXM_RS03355 76f534b20e0660bf7f57f955b5325cc4 924 SUPERFAMILY SSF48452 727 818 3.04E-12 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 59 237 5.3E-47 T 17-03-2017 IPR011538 NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 Pfam PF10531 SLBB domain 262 308 2.6E-7 T 17-03-2017 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 TIGRFAM TIGR01959 nuoF_fam: NADH oxidoreductase (quinone), F subunit 22 432 4.5E-184 T 17-03-2017 IPR011537 NADH ubiquinone oxidoreductase, F subunit GO:0010181|GO:0016651|GO:0051287|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 ProSitePatterns PS00644 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. 185 200 - T 17-03-2017 IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site GO:0008137|GO:0010181|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 SUPERFAMILY SSF142984 260 341 3.66E-21 T 17-03-2017 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 ProSitePatterns PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 359 370 - T 17-03-2017 IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site GO:0008137|GO:0010181|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 SUPERFAMILY SSF142019 18 257 3.14E-80 T 17-03-2017 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 Pfam PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 348 431 2.1E-32 T 17-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 SUPERFAMILY SSF140490 342 441 3.4E-38 T 17-03-2017 SHXM_RS30780 b97ae0d5a65d4658f06c6d34672cfa51 460 SMART SM00928 346 391 3.8E-26 T 17-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Gene3D G3DSA:2.130.10.130 28 140 1.3E-16 T 17-03-2017 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Gene3D G3DSA:2.130.10.130 156 382 2.4E-21 T 17-03-2017 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Gene3D G3DSA:2.130.10.130 383 458 1.7E-12 T 17-03-2017 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 SMART SM00191 408 465 2.2E-7 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 SMART SM00191 33 92 0.0041 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 SMART SM00191 337 396 5.3E-6 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 PRINTS PR01185 Integrin alpha subunit signature 410 434 3.0E-7 T 17-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 PRINTS PR01185 Integrin alpha subunit signature 120 132 3.0E-7 T 17-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 PRINTS PR01185 Integrin alpha subunit signature 334 354 3.0E-7 T 17-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 SUPERFAMILY SSF69318 44 437 2.81E-56 T 17-03-2017 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 116 178 1.5E-7 T 17-03-2017 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Pfam PF01839 FG-GAP repeat 45 75 4.7E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Pfam PF01839 FG-GAP repeat 341 377 1.5E-8 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS46165 a8a17bea13b23e20cc112f2fddfed9a3 484 Pfam PF01839 FG-GAP repeat 412 449 2.1E-7 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 350 472 3.5E-14 T 17-03-2017 IPR000014 PAS domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 SUPERFAMILY SSF141868 664 916 8.5E-55 T 17-03-2017 IPR001633 EAL domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 Pfam PF08448 PAS fold 360 467 3.6E-8 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 Gene3D G3DSA:3.30.450.20 357 478 9.9E-18 T 17-03-2017 SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 Gene3D G3DSA:3.30.70.270 479 655 6.2E-53 T 17-03-2017 SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 SMART SM00052 657 910 1.2E-51 T 17-03-2017 IPR001633 EAL domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 SUPERFAMILY SSF55785 342 463 9.22E-17 T 17-03-2017 IPR000014 PAS domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 SMART SM00091 353 419 6.7E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 SMART SM00267 465 647 1.3E-55 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 472 646 1.5E-38 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 SUPERFAMILY SSF55073 481 648 4.24E-41 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 Pfam PF00990 Diguanylate cyclase, GGDEF domain 476 643 9.5E-39 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 Pfam PF00563 EAL domain 664 905 2.9E-49 T 17-03-2017 IPR001633 EAL domain SHXM_RS36150 e6fcd25a83b91d4014b2fe119d3b6160 973 Gene3D G3DSA:3.20.20.450 660 915 8.9E-76 T 17-03-2017 IPR001633 EAL domain SHXM_RS50255 691d0fa8ad698291af7c7298ae00cd46 315 Pfam PF01418 Helix-turn-helix domain, rpiR family 22 94 3.2E-14 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS50255 691d0fa8ad698291af7c7298ae00cd46 315 SUPERFAMILY SSF53697 119 300 1.59E-43 T 17-03-2017 SHXM_RS50255 691d0fa8ad698291af7c7298ae00cd46 315 Gene3D G3DSA:1.10.10.10 21 95 1.6E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50255 691d0fa8ad698291af7c7298ae00cd46 315 SUPERFAMILY SSF46689 22 94 7.88E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50255 691d0fa8ad698291af7c7298ae00cd46 315 Gene3D G3DSA:3.40.50.10490 119 283 6.9E-41 T 17-03-2017 SHXM_RS50255 691d0fa8ad698291af7c7298ae00cd46 315 Pfam PF01380 SIS domain 151 278 1.7E-27 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS50130 49cdf16ed26cffca858c7309c7e53fee 529 Gene3D G3DSA:3.40.50.2300 70 295 7.3E-8 T 17-03-2017 SHXM_RS50130 49cdf16ed26cffca858c7309c7e53fee 529 SUPERFAMILY SSF53822 426 499 5.65E-13 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS50130 49cdf16ed26cffca858c7309c7e53fee 529 SUPERFAMILY SSF53822 70 385 5.65E-13 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS09900 0946e278d7211dae95584cffb13ed541 282 Pfam PF01609 Transposase DDE domain 106 193 8.7E-8 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS09900 0946e278d7211dae95584cffb13ed541 282 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 11 89 7.2E-24 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS09900 0946e278d7211dae95584cffb13ed541 282 Pfam PF13586 Transposase DDE domain 210 264 3.7E-6 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS08830 0946e278d7211dae95584cffb13ed541 282 Pfam PF01609 Transposase DDE domain 106 193 8.7E-8 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS08830 0946e278d7211dae95584cffb13ed541 282 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 11 89 7.2E-24 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS08830 0946e278d7211dae95584cffb13ed541 282 Pfam PF13586 Transposase DDE domain 210 264 3.7E-6 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS10295 0946e278d7211dae95584cffb13ed541 282 Pfam PF01609 Transposase DDE domain 106 193 8.7E-8 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS10295 0946e278d7211dae95584cffb13ed541 282 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 11 89 7.2E-24 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS10295 0946e278d7211dae95584cffb13ed541 282 Pfam PF13586 Transposase DDE domain 210 264 3.7E-6 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 SUPERFAMILY SSF52540 273 491 6.03E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 Gene3D G3DSA:3.40.50.300 267 502 6.9E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 ProSitePatterns PS00211 ABC transporters family signature. 403 417 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 SMART SM00382 36 224 5.9E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 SMART SM00382 285 479 3.3E-5 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 Gene3D G3DSA:3.40.50.300 10 244 1.5E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 SUPERFAMILY SSF52540 10 238 4.24E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 Pfam PF00005 ABC transporter 27 177 2.0E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS11390 e670066b4c12fbbf58015a883d3c020d 520 Pfam PF00005 ABC transporter 277 430 1.5E-18 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 Pfam PF10502 Signal peptidase, peptidase S26 158 248 1.1E-9 T 17-03-2017 IPR019533 Peptidase S26 SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 61 253 2.8E-40 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 ProSitePatterns PS00761 Signal peptidases I signature 3. 212 225 - T 17-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 Pfam PF00717 Peptidase S24-like 81 123 6.6E-13 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 SUPERFAMILY SSF51306 154 259 9.42E-49 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 SUPERFAMILY SSF51306 73 121 9.42E-49 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 Gene3D G3DSA:2.10.109.10 71 120 4.5E-40 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 Gene3D G3DSA:2.10.109.10 153 169 4.5E-40 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 Gene3D G3DSA:2.10.109.10 207 263 4.5E-40 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 74 90 2.8E-20 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 159 171 2.8E-20 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36600 c4c9cc7d37440f44633f1518e0a21073 395 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 207 226 2.8E-20 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 SUPERFAMILY SSF53850 97 284 2.9E-19 T 17-03-2017 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 Gene3D G3DSA:3.40.190.10 90 191 8.8E-15 T 17-03-2017 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 9 65 3.5E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 SUPERFAMILY SSF46785 4 102 3.39E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 Gene3D G3DSA:3.40.190.10 192 236 7.4E-5 T 17-03-2017 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 22 33 2.9E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 43 54 2.9E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 33 43 2.9E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 Gene3D G3DSA:1.10.10.10 6 86 2.5E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10895 910bb9f76056d4d57cc01b6a849891e9 293 Pfam PF03466 LysR substrate binding domain 97 280 4.1E-18 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS23785 f5570e01ad48fabaf9da4162dc154602 254 SUPERFAMILY SSF161098 1 254 8.63E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23785 f5570e01ad48fabaf9da4162dc154602 254 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 80 246 1.9E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23785 f5570e01ad48fabaf9da4162dc154602 254 Gene3D G3DSA:1.10.3720.10 1 242 1.2E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:3.40.50.980 46 188 8.5E-21 T 17-03-2017 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:1.10.1200.10 577 654 1.8E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:3.30.300.30 445 552 2.7E-13 T 17-03-2017 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 SMART SM00824 Thioesterase 680 926 3.7E-4 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 SUPERFAMILY SSF56801 13 557 4.32E-102 T 17-03-2017 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 SMART SM00823 Phosphopantetheine attachment site 584 657 1.2E-6 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Pfam PF00975 Thioesterase domain 678 921 6.8E-33 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Pfam PF00501 AMP-binding enzyme 45 451 2.0E-65 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 SUPERFAMILY SSF47336 579 671 8.24E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS34795 afd378dd79317db49f3f753517697080 949 ProSitePatterns PS00455 Putative AMP-binding domain signature. 183 194 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:3.40.50.1820 663 781 2.8E-47 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:3.40.50.1820 863 934 2.8E-47 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:2.30.38.10 372 444 1.8E-25 T 17-03-2017 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Gene3D G3DSA:3.40.50.980 189 360 9.0E-29 T 17-03-2017 SHXM_RS34795 afd378dd79317db49f3f753517697080 949 Pfam PF00550 Phosphopantetheine attachment site 588 653 2.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS34795 afd378dd79317db49f3f753517697080 949 SUPERFAMILY SSF53474 661 933 2.88E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 ProSitePatterns PS00788 Chorismate synthase signature 2. 136 152 - T 17-03-2017 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 Gene3D G3DSA:3.60.150.10 4 391 8.6E-154 T 17-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 TIGRFAM TIGR00033 aroC: chorismate synthase 4 374 6.4E-140 T 17-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 ProSitePatterns PS00787 Chorismate synthase signature 1. 10 25 - T 17-03-2017 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 SUPERFAMILY SSF103263 3 390 1.57E-137 T 17-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 Pfam PF01264 Chorismate synthase 4 368 4.2E-117 T 17-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 Hamap MF_00300 Chorismate synthase [aroC]. 4 376 34.097 T 17-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 PIRSF PIRSF001456 1 386 9.1E-127 T 17-03-2017 IPR000453 Chorismate synthase GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS12420 c907677958b00df21ffc338f5bfc5348 394 ProSitePatterns PS00789 Chorismate synthase signature 3. 343 359 - T 17-03-2017 IPR020541 Chorismate synthase, conserved site GO:0004107|GO:0009073 KEGG: 00400+4.2.3.5|MetaCyc: PWY-6163 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SMART SM00671 461 492 0.037 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SMART SM00671 493 525 140.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SMART SM00671 72 102 350.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SMART SM00671 103 134 64.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SUPERFAMILY SSF81901 400 590 1.96E-20 T 17-03-2017 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SUPERFAMILY SSF81901 223 332 2.62E-13 T 17-03-2017 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 Pfam PF13432 Tetratricopeptide repeat 532 590 0.0044 T 17-03-2017 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 SUPERFAMILY SSF81901 34 169 7.59E-16 T 17-03-2017 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 Gene3D G3DSA:1.25.40.10 389 589 1.2E-24 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 Gene3D G3DSA:1.25.40.10 31 178 7.7E-18 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21860 1a0f3df3a3b8fe457ca8c0c02b3a67c6 607 Gene3D G3DSA:1.25.40.10 196 332 3.1E-12 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS49340 76f4e5d21a4a4264488f35339b354cb3 446 Gene3D G3DSA:3.30.420.10 157 265 2.0E-4 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS49340 76f4e5d21a4a4264488f35339b354cb3 446 Gene3D G3DSA:3.30.420.10 81 123 2.0E-4 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS49340 76f4e5d21a4a4264488f35339b354cb3 446 Pfam PF09299 Mu transposase, C-terminal 295 349 6.3E-5 T 17-03-2017 IPR015378 Transposase-like, Mu, C-terminal SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF13602 Zinc-binding dehydrogenase 1655 1788 8.1E-21 T 17-03-2017 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF14765 Polyketide synthase dehydratase 954 1243 1.0E-52 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 581 884 2.5E-107 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.90.180.10 1495 1613 7.9E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM00826 954 1121 1.8E-83 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 47 296 3.5E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF55048 704 772 2.75E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF47336 2077 2163 2.22E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF50129 1496 1614 9.75E-28 T 17-03-2017 IPR011032 GroES-like SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM00825 Beta-ketoacyl synthase 49 474 2.9E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM00829 1481 1788 1.5E-182 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.40.50.720 1614 1709 1.8E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM01294 2086 2153 8.0E-6 T 17-03-2017 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.40.47.10 309 474 1.2E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF53901 43 414 8.42E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF51735 1580 1717 1.51E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.40.50.720 1798 1988 2.1E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 304 421 4.5E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2112 2127 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF00698 Acyl transferase domain 580 903 6.2E-78 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF51735 1251 1458 2.6E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF00550 Phosphopantetheine attachment site 2088 2153 1.9E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF101173 16 47 5.49E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1798 1978 8.5E-45 T 17-03-2017 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.40.366.10 772 887 5.5E-67 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.40.366.10 579 700 5.5E-67 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF51735 1797 2029 8.38E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.30.70.250 704 771 3.1E-8 T 17-03-2017 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF08990 Erythronolide synthase docking 15 40 7.0E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 209 225 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SMART SM00823 Phosphopantetheine attachment site 2085 2157 1.7E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF08659 KR domain 1798 1976 2.9E-52 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 424 541 6.5E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1501 1556 1.3E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF52151 773 878 1.07E-60 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 SUPERFAMILY SSF52151 579 706 1.07E-60 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:1.10.1200.10 2082 2157 3.0E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06455 398f3f0bb6fdb4d811ac3111f8c43be0 2248 Gene3D G3DSA:3.40.47.10 49 308 2.8E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 SUPERFAMILY SSF53850 90 282 1.21E-22 T 17-03-2017 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 Gene3D G3DSA:3.40.190.10 173 253 1.1E-8 T 17-03-2017 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 Pfam PF03466 LysR substrate binding domain 89 278 2.5E-21 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 Gene3D G3DSA:1.10.10.10 2 82 1.6E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 Gene3D G3DSA:3.40.190.10 90 172 4.7E-12 T 17-03-2017 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 SUPERFAMILY SSF46785 4 84 6.25E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 1.3E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 2.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 2.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05255 e3565fba67a95aeec343e91fcd16e162 284 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 2.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Pfam PF13328 HD domain 68 215 3.4E-39 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 SUPERFAMILY SSF81271 431 489 5.67E-9 T 17-03-2017 IPR012676 TGS-like KEGG: 00970+6.1.1.3 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Pfam PF02824 TGS domain 431 489 2.7E-13 T 17-03-2017 IPR004095 TGS KEGG: 00970+6.1.1.3 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 SUPERFAMILY SSF109604 47 231 4.71E-62 T 17-03-2017 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Gene3D G3DSA:3.30.70.260 654 726 4.6E-7 T 17-03-2017 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 SUPERFAMILY SSF81301 232 407 5.07E-32 T 17-03-2017 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 SMART SM00954 274 382 2.6E-24 T 17-03-2017 IPR007685 RelA/SpoT GO:0015969 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Pfam PF13291 ACT domain 652 728 7.4E-13 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Gene3D G3DSA:3.10.20.30 430 490 7.4E-11 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 SUPERFAMILY SSF55021 654 728 1.5E-6 T 17-03-2017 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 SMART SM00471 83 193 8.8E-12 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Gene3D G3DSA:3.30.460.10 218 361 7.1E-23 T 17-03-2017 SHXM_RS37345 7d9a73ad4788a583c52059ce0a6b7dae 738 Pfam PF04607 Region found in RelA / SpoT proteins 296 369 7.0E-14 T 17-03-2017 IPR007685 RelA/SpoT GO:0015969 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 SUPERFAMILY SSF54368 5 99 8.24E-29 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 Pfam PF00120 Glutamine synthetase, catalytic domain 102 466 1.1E-137 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 Pfam PF03951 Glutamine synthetase, beta-Grasp domain 16 94 5.6E-23 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 SMART SM01230 101 378 2.6E-152 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 TIGRFAM TIGR00653 GlnA: glutamine synthetase, type I 8 468 7.6E-200 T 17-03-2017 IPR004809 Glutamine synthetase type I GO:0004356|GO:0005737|GO:0009399 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 ProSitePatterns PS00180 Glutamine synthetase signature 1. 49 67 - T 17-03-2017 IPR027302 Glutamine synthetase, N-terminal conserved site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 ProSitePatterns PS00182 Glutamine synthetase class-I adenylation site. 385 397 - T 17-03-2017 IPR001637 Glutamine synthetase class-I, adenylation site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 Gene3D G3DSA:3.30.590.10 105 448 1.6E-137 T 17-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 256 271 - T 17-03-2017 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 Gene3D G3DSA:3.10.20.70 5 104 5.0E-33 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19105 4279460b26def6e807e14ef55fc037c2 469 SUPERFAMILY SSF55931 102 468 2.94E-138 T 17-03-2017 SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2 246 1.8E-30 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 Gene3D G3DSA:3.40.47.10 264 417 2.9E-33 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 161 177 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 SUPERFAMILY SSF53901 3 107 8.57E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 SUPERFAMILY SSF53901 144 408 8.57E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 Gene3D G3DSA:3.40.47.10 6 258 3.0E-38 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 255 373 1.5E-19 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS23105 4171cb97e0f82e0a8d4a5bee8ddf3fb3 419 SMART SM00825 Beta-ketoacyl synthase 4 419 4.7E-11 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.47.10 3133 3397 4.6E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00823 Phosphopantetheine attachment site 1498 1570 1.5E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00823 Phosphopantetheine attachment site 3042 3114 1.3E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00823 Phosphopantetheine attachment site 4599 4671 5.0E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF47336 3036 3149 7.33E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00825 Beta-ketoacyl synthase 37 462 3.4E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00825 Beta-ketoacyl synthase 1592 2018 1.0E-218 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00825 Beta-ketoacyl synthase 3137 3563 5.0E-223 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 284 2.2E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3135 3385 1.3E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1590 1840 3.7E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.366.10 765 880 6.5E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.366.10 568 696 6.5E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF52151 3864 3958 2.59E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF52151 3668 3800 2.59E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF52151 571 696 1.96E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF52151 758 860 1.96E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3069 3084 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1525 1540 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF52151 2316 2412 7.85E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF52151 2121 2252 7.85E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF51735 4309 4540 2.82E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF51735 2758 2984 3.36E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00698 Acyl transferase domain 2123 2443 4.3E-59 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00698 Acyl transferase domain 3671 3992 1.2E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00698 Acyl transferase domain 573 897 3.1E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.47.10 3398 3563 3.7E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.47.10 297 463 4.7E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.47.10 1853 2017 7.9E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF08659 KR domain 1214 1392 3.7E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF08659 KR domain 2759 2937 3.8E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF08659 KR domain 4314 4491 5.9E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM01294 4600 4667 1.4E-5 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM01294 1499 1566 7.0E-7 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM01294 3043 3110 1.4E-6 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF51735 2536 2747 1.73E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF53901 3132 3500 6.66E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF51735 990 1201 1.34E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF55048 2251 2315 8.11E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF47336 4593 4678 1.57E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.50.720 1213 1395 4.2E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.50.720 4312 4495 9.0E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.47.10 37 296 4.0E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.47.10 1592 1852 1.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF51735 4090 4300 2.07E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00550 Phosphopantetheine attachment site 3045 3110 6.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00550 Phosphopantetheine attachment site 1500 1566 1.4E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF00550 Phosphopantetheine attachment site 4602 4667 3.0E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1214 1393 2.8E-53 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4314 4493 1.8E-49 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2759 2938 9.0E-56 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3298 3314 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1753 1769 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.50.720 2761 2959 3.2E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:1.10.1200.10 1496 1570 8.2E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:1.10.1200.10 3039 3113 5.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:1.10.1200.10 4597 4669 2.3E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.30.70.250 3798 3863 2.8E-9 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.30.70.250 701 764 3.6E-7 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.30.70.250 2251 2315 2.5E-7 T 17-03-2017 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF53901 1587 1961 7.25E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF51735 1209 1466 1.55E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3672 3976 5.2E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 574 878 2.4E-130 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2124 2426 2.2E-135 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.366.10 3659 3795 3.3E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.366.10 3864 3990 3.3E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.366.10 2316 2440 1.4E-84 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Gene3D G3DSA:3.40.366.10 2110 2247 1.4E-84 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3513 3635 2.7E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 536 7.8E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1968 2085 1.8E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF53901 32 407 4.03E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1848 1965 2.0E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3393 3510 1.2E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 8.0E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF55048 3799 3863 6.02E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF55048 701 765 1.06E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45360 5aaf8e2c0bba5f6c44c41eed3f8a6fd9 4751 SUPERFAMILY SSF47336 1494 1605 8.24E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS34860 6bc5ddfc21ea8fb430db7e5e505b1fba 248 SUPERFAMILY SSF53335 20 223 6.6E-21 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS34860 6bc5ddfc21ea8fb430db7e5e505b1fba 248 Gene3D G3DSA:3.40.50.150 83 219 7.1E-22 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24225 bc7fed2e1140d21bd0dd563fe696a16f 323 TIGRFAM TIGR01819 F420_cofD: 2-phospho-L-lactate transferase 3 314 1.2E-129 T 17-03-2017 IPR010115 2-phospho-L-lactate transferase GO:0000287|GO:0016780|GO:0051188 KEGG: 00680+2.7.8.28|MetaCyc: PWY-5198 SHXM_RS24225 bc7fed2e1140d21bd0dd563fe696a16f 323 Pfam PF01933 Uncharacterised protein family UPF0052 3 280 2.0E-60 T 17-03-2017 IPR002882 LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052 SHXM_RS24225 bc7fed2e1140d21bd0dd563fe696a16f 323 SUPERFAMILY SSF142338 3 318 2.49E-84 T 17-03-2017 SHXM_RS24225 bc7fed2e1140d21bd0dd563fe696a16f 323 Gene3D G3DSA:3.40.50.10680 87 321 1.7E-82 T 17-03-2017 SHXM_RS24225 bc7fed2e1140d21bd0dd563fe696a16f 323 Hamap MF_01257 2-phospho-L-lactate transferase [cofD]. 1 323 136.98 T 17-03-2017 IPR010115 2-phospho-L-lactate transferase GO:0000287|GO:0016780|GO:0051188 KEGG: 00680+2.7.8.28|MetaCyc: PWY-5198 SHXM_RS40990 6be1905372cdfdb12a2699710ea5e1b0 594 Gene3D G3DSA:2.60.120.10 246 480 9.5E-35 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS40990 6be1905372cdfdb12a2699710ea5e1b0 594 PIRSF PIRSF026713 11 594 5.1E-208 T 17-03-2017 IPR016847 Mannose-6-phosphate isomerase, Firmicutes, long form, predicted SHXM_RS40990 6be1905372cdfdb12a2699710ea5e1b0 594 SUPERFAMILY SSF51182 246 482 3.49E-49 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS40990 6be1905372cdfdb12a2699710ea5e1b0 594 SUPERFAMILY SSF51182 509 582 3.49E-49 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS40990 6be1905372cdfdb12a2699710ea5e1b0 594 Gene3D G3DSA:2.60.120.10 516 589 1.7E-5 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS42370 60267ee09a41bcfcd464466de3ead4a0 296 SUPERFAMILY SSF51735 1 275 3.08E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42370 60267ee09a41bcfcd464466de3ead4a0 296 Gene3D G3DSA:3.40.50.720 2 242 1.5E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42370 60267ee09a41bcfcd464466de3ead4a0 296 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 217 4.9E-25 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS48795 9a3b44a1012d1a0b869e23a291a3b479 326 Gene3D G3DSA:3.90.245.10 10 319 3.1E-94 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS48795 9a3b44a1012d1a0b869e23a291a3b479 326 Pfam PF01156 Inosine-uridine preferring nucleoside hydrolase 11 310 5.6E-62 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS48795 9a3b44a1012d1a0b869e23a291a3b479 326 SUPERFAMILY SSF53590 9 318 2.49E-84 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 Pfam PF01078 Magnesium chelatase, subunit ChlI 113 182 1.9E-7 T 17-03-2017 IPR000523 Magnesium chelatase ChlI domain SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 Pfam PF13519 von Willebrand factor type A domain 527 633 1.5E-16 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 TIGRFAM TIGR02442 Cob-chelat-sub: cobaltochelatase subunit 5 694 5.5E-250 T 17-03-2017 IPR012804 Cobaltochelatase subunit, putative SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 SUPERFAMILY SSF53300 527 669 1.53E-20 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 Gene3D G3DSA:1.10.8.80 248 335 1.1E-31 T 17-03-2017 SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 Gene3D G3DSA:3.40.50.300 4 201 2.0E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 Gene3D G3DSA:3.40.50.410 527 668 4.5E-13 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 SUPERFAMILY SSF52540 5 324 8.71E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 SMART SM00327 524 706 8.1E-22 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS17525 859ae32c0e0e0db9b3e7982405da53d8 718 SMART SM00382 28 205 9.0E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17600 89fa32083cdc1cd48792c1bf1af6857a 527 Gene3D G3DSA:3.40.605.10 23 269 3.9E-40 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS17600 89fa32083cdc1cd48792c1bf1af6857a 527 Gene3D G3DSA:3.40.309.10 270 457 1.2E-50 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS17600 89fa32083cdc1cd48792c1bf1af6857a 527 Pfam PF00171 Aldehyde dehydrogenase family 21 460 2.3E-42 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS17600 89fa32083cdc1cd48792c1bf1af6857a 527 SUPERFAMILY SSF53720 22 518 6.54E-84 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS27675 a90567069165f99d723dbefe3092a66f 413 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 64 401 9.0E-92 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS27675 a90567069165f99d723dbefe3092a66f 413 SUPERFAMILY SSF54909 59 406 2.15E-82 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS27675 a90567069165f99d723dbefe3092a66f 413 Pfam PF04261 Dyp-type peroxidase family 64 400 9.6E-104 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS27675 a90567069165f99d723dbefe3092a66f 413 TIGRFAM TIGR01412 tat_substr_1: Tat-translocated enzyme 5 412 9.2E-151 T 17-03-2017 IPR006313 Deferrochelatase/peroxidase EfeB GO:0004601|GO:0015684|GO:0020037|GO:0033212 SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 Gene3D G3DSA:3.40.50.720 5 258 7.0E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 164 183 3.2E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 3.2E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 3.2E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 2.4E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 2.4E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 220 240 2.4E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 183 2.4E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 2.4E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 2.4E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 SUPERFAMILY SSF51735 11 258 3.64E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 151 179 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS10660 d9d009f1db47f5fdb2bab946e1cd2189 259 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 22 257 3.2E-53 T 17-03-2017 SHXM_RS04095 eefd80b9a660b8655072e5be2eb59db4 287 PIRSF PIRSF017393 5 287 3.7E-105 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS04095 eefd80b9a660b8655072e5be2eb59db4 287 Gene3D G3DSA:3.40.50.150 13 286 4.6E-117 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04095 eefd80b9a660b8655072e5be2eb59db4 287 SUPERFAMILY SSF53335 26 260 3.68E-50 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04095 eefd80b9a660b8655072e5be2eb59db4 287 Pfam PF04672 S-adenosyl methyltransferase 18 286 1.9E-111 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 528 615 2.9E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Gene3D G3DSA:3.40.50.2300 5 131 1.6E-27 T 17-03-2017 SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SMART SM00448 6 119 4.3E-20 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SMART SM00387 522 617 2.9E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SUPERFAMILY SSF52172 5 129 1.99E-27 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SUPERFAMILY SSF55785 159 262 4.06E-14 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Gene3D G3DSA:3.30.565.10 507 616 3.7E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 162 272 1.7E-13 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 270 389 5.9E-23 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SUPERFAMILY SSF55874 515 615 2.44E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Pfam PF07730 Histidine kinase 420 485 5.2E-10 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Pfam PF13426 PAS domain 283 384 1.8E-13 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Pfam PF13426 PAS domain 171 266 2.7E-10 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Gene3D G3DSA:3.30.450.20 267 383 3.7E-26 T 17-03-2017 SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SMART SM00091 273 339 1.6E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SMART SM00091 161 227 4.7E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 SUPERFAMILY SSF55785 267 383 4.58E-24 T 17-03-2017 IPR000014 PAS domain SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Pfam PF00072 Response regulator receiver domain 8 119 3.8E-19 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26630 2ad057334dade4547ea21f4da6ed220b 634 Gene3D G3DSA:3.30.450.20 169 263 3.2E-13 T 17-03-2017 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 SUPERFAMILY SSF57716 214 259 9.41E-11 T 17-03-2017 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 SUPERFAMILY SSF81624 2 125 1.31E-27 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 SMART SM00898 2 110 1.1E-23 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 ProSitePatterns PS01242 Zinc finger FPG-type signature. 231 259 - T 17-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 124 195 3.6E-10 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 SUPERFAMILY SSF46946 123 188 7.21E-19 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 SMART SM01232 124 212 2.0E-23 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 91 4.2E-8 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 Gene3D G3DSA:3.20.190.10 2 124 1.2E-16 T 17-03-2017 SHXM_RS37200 ece4cfa85cf29d06d8ea40688ec9c4eb 268 Gene3D G3DSA:1.10.8.50 125 259 1.0E-38 T 17-03-2017 SHXM_RS37675 ed67915e68e20899c6bc44c2debc086f 503 Gene3D G3DSA:3.30.565.10 209 328 4.3E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37675 ed67915e68e20899c6bc44c2debc086f 503 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 221 326 6.4E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37675 ed67915e68e20899c6bc44c2debc086f 503 SUPERFAMILY SSF55874 200 327 1.44E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 5.7E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 5.7E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 5.7E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 Pfam PF01037 Lrp/AsnC ligand binding domain 67 137 8.0E-16 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 Gene3D G3DSA:3.30.70.920 54 133 7.0E-25 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 SMART SM00344 3 108 2.1E-45 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 SUPERFAMILY SSF54909 61 143 1.47E-15 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 Pfam PF13404 AsnC-type helix-turn-helix domain 3 42 2.8E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 Gene3D G3DSA:1.10.10.10 3 53 8.5E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11575 eed8cfe54877427058927002164ccbab 146 SUPERFAMILY SSF46785 2 60 2.02E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20690 d6565e7c11ea13e2f945fa2e710db098 149 SMART SM00960 12 112 1.5E-16 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS20690 d6565e7c11ea13e2f945fa2e710db098 149 Gene3D G3DSA:3.30.450.30 7 138 6.5E-20 T 17-03-2017 SHXM_RS20690 d6565e7c11ea13e2f945fa2e710db098 149 SUPERFAMILY SSF103196 8 141 7.06E-23 T 17-03-2017 SHXM_RS20690 d6565e7c11ea13e2f945fa2e710db098 149 Pfam PF03259 Roadblock/LC7 domain 15 111 2.4E-15 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS19910 cf33204c748a8012100419ab3dcfe248 277 Pfam PF13560 Helix-turn-helix domain 11 91 2.5E-16 T 17-03-2017 SHXM_RS19910 cf33204c748a8012100419ab3dcfe248 277 Gene3D G3DSA:1.10.260.40 6 85 3.0E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19910 cf33204c748a8012100419ab3dcfe248 277 SUPERFAMILY SSF47413 34 85 1.69E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19910 cf33204c748a8012100419ab3dcfe248 277 SMART SM00530 15 88 2.1E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 Gene3D G3DSA:1.10.10.10 154 210 8.2E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 Pfam PF03861 ANTAR domain 155 207 8.5E-21 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 Gene3D G3DSA:3.40.50.2300 22 147 2.1E-38 T 17-03-2017 SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 SMART SM01012 152 207 1.7E-24 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 Pfam PF00072 Response regulator receiver domain 27 136 1.3E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 SUPERFAMILY SSF52172 24 207 1.28E-55 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 SMART SM00448 25 136 1.2E-37 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS18175 9eabd1dc81d3e8004a09b4a83cdb102c 218 PIRSF PIRSF036382 17 214 1.1E-69 T 17-03-2017 IPR008327 Signal transduction response regulator, antiterminator SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 Gene3D G3DSA:3.40.50.1820 10 285 8.1E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 PRINTS PR00412 Epoxide hydrolase signature 61 76 4.1E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 PRINTS PR00412 Epoxide hydrolase signature 106 119 4.1E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 PRINTS PR00412 Epoxide hydrolase signature 260 282 4.1E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 PRINTS PR00412 Epoxide hydrolase signature 120 133 4.1E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 Pfam PF12697 Alpha/beta hydrolase family 38 277 2.9E-19 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS25555 8a8965e53191d01a393d2b106f89ec22 289 SUPERFAMILY SSF53474 10 283 3.98E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16685 c38ddada29ec370558acaa30ea74d4e3 333 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 155 332 5.3E-39 T 17-03-2017 SHXM_RS16685 c38ddada29ec370558acaa30ea74d4e3 333 SUPERFAMILY SSF51735 3 142 1.3E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16685 c38ddada29ec370558acaa30ea74d4e3 333 SUPERFAMILY SSF51735 153 332 1.78E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16685 c38ddada29ec370558acaa30ea74d4e3 333 Pfam PF08659 KR domain 155 333 7.8E-53 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16685 c38ddada29ec370558acaa30ea74d4e3 333 Gene3D G3DSA:3.40.50.720 155 328 2.1E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43275 d9e8695f5f18dd0c04bfd71dbadfcd44 157 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 23 154 1.4E-22 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS43275 d9e8695f5f18dd0c04bfd71dbadfcd44 157 Gene3D G3DSA:3.30.530.20 23 154 3.2E-21 T 17-03-2017 IPR023393 START-like domain SHXM_RS43275 d9e8695f5f18dd0c04bfd71dbadfcd44 157 SUPERFAMILY SSF55961 18 154 3.1E-27 T 17-03-2017 SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 5.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 5.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 206 226 5.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 5.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 5.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 5.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 241 2.8E-52 T 17-03-2017 SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 6.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 6.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 6.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 SUPERFAMILY SSF51735 1 244 7.59E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04495 5265dcdd0a797d80d63ca2213868fd06 246 Gene3D G3DSA:3.40.50.720 1 244 2.3E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 Pfam PF01037 Lrp/AsnC ligand binding domain 72 138 6.9E-12 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 Gene3D G3DSA:3.30.70.920 56 142 2.3E-17 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 SUPERFAMILY SSF54909 63 148 1.61E-15 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 SMART SM00344 3 109 1.3E-24 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 Pfam PF13404 AsnC-type helix-turn-helix domain 3 44 5.1E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 Gene3D G3DSA:1.10.10.10 2 53 6.7E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 SUPERFAMILY SSF46785 3 63 7.55E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 30 49 2.2E-9 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 3 19 2.2E-9 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS23545 5dab7f315d305c071031773ecb44dee9 155 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 19 30 2.2E-9 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS14890 31124d1e6ab572e0f63c42952da03a0e 185 Pfam PF00857 Isochorismatase family 10 173 4.5E-40 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS14890 31124d1e6ab572e0f63c42952da03a0e 185 SUPERFAMILY SSF52499 8 184 3.53E-49 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS14890 31124d1e6ab572e0f63c42952da03a0e 185 Gene3D G3DSA:3.40.50.850 8 181 4.6E-49 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS45915 72770fbef3d359971e6fa747a286ead8 396 TIGRFAM TIGR03082 Gneg_AbrB_dup: membrane protein AbrB duplication 234 389 1.0E-34 T 17-03-2017 IPR017516 AbrB duplication SHXM_RS45915 72770fbef3d359971e6fa747a286ead8 396 TIGRFAM TIGR03082 Gneg_AbrB_dup: membrane protein AbrB duplication 42 198 1.3E-34 T 17-03-2017 IPR017516 AbrB duplication SHXM_RS45915 72770fbef3d359971e6fa747a286ead8 396 Pfam PF05145 Putative ammonia monooxygenase 85 389 2.1E-73 T 17-03-2017 IPR007820 AbrB family GO:0010468|GO:0016021 SHXM_RS45915 72770fbef3d359971e6fa747a286ead8 396 PIRSF PIRSF038991 32 395 9.7E-72 T 17-03-2017 IPR007820 AbrB family GO:0010468|GO:0016021 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 SUPERFAMILY SSF55874 808 886 1.05E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Gene3D G3DSA:3.30.450.20 53 186 1.2E-32 T 17-03-2017 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 SUPERFAMILY SSF55781 414 525 3.05E-11 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Pfam PF01590 GAF domain 429 514 2.4E-5 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 SUPERFAMILY SSF103190 56 184 2.51E-26 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Gene3D G3DSA:3.30.450.40 347 523 1.6E-30 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 SMART SM00331 543 764 1.5E-18 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 570 764 3.5E-37 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Gene3D G3DSA:3.30.450.20 230 327 1.2E-6 T 17-03-2017 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Pfam PF13581 Histidine kinase-like ATPase domain 778 884 4.1E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 Pfam PF17203 Single cache domain 3 55 184 5.0E-17 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS05095 ccc9cb172fd4ec788b3d423966b45c01 893 SMART SM00091 228 293 3.4E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 TIGRFAM TIGR03448 mycothiol_MshD: mycothiol synthase 18 306 1.1E-112 T 17-03-2017 IPR017813 Mycothiol acetyltransferase GO:0016747 SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 Hamap MF_01698 Mycothiol acetyltransferase [mshD]. 14 308 35.705 T 17-03-2017 IPR017813 Mycothiol acetyltransferase GO:0016747 SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 Pfam PF00583 Acetyltransferase (GNAT) family 68 136 3.9E-6 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 Pfam PF00583 Acetyltransferase (GNAT) family 220 297 1.4E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 SUPERFAMILY SSF55729 15 306 1.96E-46 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 Gene3D G3DSA:3.40.630.30 167 306 1.2E-31 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 Gene3D G3DSA:3.40.630.30 18 136 3.7E-11 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS26230 6c987d343dfb5cfcc81c549c5eb7b712 310 PIRSF PIRSF021524 9 310 6.8E-106 T 17-03-2017 IPR017813 Mycothiol acetyltransferase GO:0016747 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 SUPERFAMILY SSF55545 5 138 2.69E-23 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 Gene3D G3DSA:3.20.20.80 137 510 3.2E-113 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 140 483 1.2E-96 T 17-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 SUPERFAMILY SSF51445 140 494 1.98E-100 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 447 463 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 233 250 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 465 482 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 90 110 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 281 299 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 162 183 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 133 150 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 PRINTS PR00738 Glycosyl hydrolase family 20 signature 303 316 7.5E-46 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 Gene3D G3DSA:3.30.379.10 2 135 1.7E-28 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS40385 563deba55bae88ebdb7bb0f4357a88a8 510 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 8 135 3.0E-18 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS08115 d4c186b37deb47453ba1eb054c09360f 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 127 293 1.2E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08115 d4c186b37deb47453ba1eb054c09360f 304 SUPERFAMILY SSF161098 28 304 2.35E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08115 d4c186b37deb47453ba1eb054c09360f 304 Gene3D G3DSA:1.10.3720.10 28 292 3.0E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS44750 c40a05b92ec179450a37440079b9b7be 140 SUPERFAMILY SSF54427 38 137 4.24E-33 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS44750 c40a05b92ec179450a37440079b9b7be 140 Hamap MF_00612 UPF0225 protein YchJ [ychJ]. 14 137 26.984 T 17-03-2017 IPR023006 Uncharacterised protein family UPF0225 SHXM_RS44750 c40a05b92ec179450a37440079b9b7be 140 Gene3D G3DSA:3.10.450.50 17 137 2.2E-41 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS49435 2916f4476e0c2eb2172785284055c2f2 128 SUPERFAMILY SSF82784 42 111 7.98E-9 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS49435 2916f4476e0c2eb2172785284055c2f2 128 Pfam PF02566 OsmC-like protein 42 105 1.7E-5 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS49435 2916f4476e0c2eb2172785284055c2f2 128 Gene3D G3DSA:3.30.300.20 41 112 2.1E-8 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS08215 3e88f6a7fc3e37d0e972171d2a1b73ab 280 SMART SM00382 34 226 6.3E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS08215 3e88f6a7fc3e37d0e972171d2a1b73ab 280 Gene3D G3DSA:3.40.50.300 4 249 1.1E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08215 3e88f6a7fc3e37d0e972171d2a1b73ab 280 Pfam PF00005 ABC transporter 26 177 2.5E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS08215 3e88f6a7fc3e37d0e972171d2a1b73ab 280 SUPERFAMILY SSF52540 5 248 1.15E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08215 3e88f6a7fc3e37d0e972171d2a1b73ab 280 ProSitePatterns PS00211 ABC transporters family signature. 149 163 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS15670 f20a688afe66164245b946db8858bf45 102 SMART SM00530 27 82 1.5E-13 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS15670 f20a688afe66164245b946db8858bf45 102 Pfam PF01381 Helix-turn-helix 28 79 3.6E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS15670 f20a688afe66164245b946db8858bf45 102 Gene3D G3DSA:1.10.260.40 23 79 1.3E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15670 f20a688afe66164245b946db8858bf45 102 SUPERFAMILY SSF47413 25 92 4.02E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 SMART SM00895 87 228 2.3E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 37 51 1.2E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 51 67 1.2E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 Pfam PF00392 Bacterial regulatory proteins, gntR family 18 77 2.9E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 Pfam PF07729 FCD domain 87 227 6.2E-24 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 SUPERFAMILY SSF46785 17 81 6.04E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 SMART SM00345 19 77 2.4E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 SUPERFAMILY SSF48008 84 234 1.46E-20 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 Gene3D G3DSA:1.20.120.530 80 235 5.9E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS37530 8fd1aeec4d3fcfea4e85fa311826654c 255 Gene3D G3DSA:1.10.10.10 16 78 2.1E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15630 2915ef04d38556bd5b764f78bedc334d 997 ProDom PD039135 WALL-ASSOCIATED REPEAT PROTEIN CELL WALL HYDROLASE PRECURSOR SIGNAL TRANSMEMBRANE RETICULOCYTE 62 260 1.0E-6 T 17-03-2017 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF53901 983 1351 5.88E-96 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1497 1783 4.3E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 544 835 1.1E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF08659 KR domain 2034 2207 2.8E-51 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00823 Phosphopantetheine attachment site 2308 2380 6.3E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00823 Phosphopantetheine attachment site 901 973 2.3E-25 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.47.10 287 450 2.8E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.47.10 1243 1404 8.4E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:1.10.1200.10 2307 2381 5.7E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:1.10.1200.10 898 971 1.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.366.10 1494 1613 5.7E-69 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.366.10 541 660 7.5E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.366.10 725 835 7.5E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.366.10 1678 1783 5.7E-69 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 274 2.9E-79 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 987 1230 3.1E-79 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 187 203 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF51735 2032 2259 2.51E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF08990 Erythronolide synthase docking 3 26 4.4E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM01294 2309 2376 5.5E-6 T 17-03-2017 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM01294 902 969 8.0E-5 T 17-03-2017 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00825 Beta-ketoacyl synthase 989 1405 3.8E-181 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00825 Beta-ketoacyl synthase 37 450 1.6E-201 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 282 397 7.1E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1238 1353 5.0E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF00550 Phosphopantetheine attachment site 903 969 5.7E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF00550 Phosphopantetheine attachment site 2310 2376 4.4E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF51735 1838 2022 3.54E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1366 1469 1.6E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 403 486 1.1E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 ProSitePatterns PS00012 Phosphopantetheine attachment site. 928 943 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.47.10 984 1242 1.8E-85 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1143 1159 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2335 2350 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF55048 665 724 1.57E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF47336 2302 2383 8.77E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2034 2209 9.6E-44 T 17-03-2017 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF00698 Acyl transferase domain 1495 1784 1.3E-73 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Pfam PF00698 Acyl transferase domain 542 854 2.0E-80 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF52151 541 666 5.75E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF52151 727 825 5.75E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF53901 31 396 3.01E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF52151 1680 1774 1.75E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF52151 1494 1619 1.75E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.30.70.250 665 718 9.7E-8 T 17-03-2017 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.30.70.250 1618 1671 1.3E-7 T 17-03-2017 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF55048 1618 1677 1.09E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.50.720 2033 2239 9.3E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 Gene3D G3DSA:3.40.47.10 37 286 1.6E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46790 9ff484e130295cd4dd16dbac3401daae 2451 SUPERFAMILY SSF47336 896 1002 1.31E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS43995 c5f360617eb140cb94bda72711264e73 274 TIGRFAM TIGR00654 PhzF_family: phenazine biosynthesis protein, PhzF family 4 243 1.5E-40 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS43995 c5f360617eb140cb94bda72711264e73 274 Gene3D G3DSA:3.10.310.10 132 262 6.9E-40 T 17-03-2017 SHXM_RS43995 c5f360617eb140cb94bda72711264e73 274 Pfam PF02567 Phenazine biosynthesis-like protein 6 270 1.7E-63 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS43995 c5f360617eb140cb94bda72711264e73 274 SUPERFAMILY SSF54506 2 272 1.29E-71 T 17-03-2017 SHXM_RS43995 c5f360617eb140cb94bda72711264e73 274 Gene3D G3DSA:3.10.310.10 2 131 1.9E-40 T 17-03-2017 SHXM_RS43995 c5f360617eb140cb94bda72711264e73 274 PIRSF PIRSF016184 1 274 8.9E-52 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 SMART SM00878 333 441 2.0E-56 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Pfam PF02785 Biotin carboxylase C-terminal domain 333 441 3.6E-36 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Gene3D G3DSA:3.40.50.20 2 128 4.1E-49 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Gene3D G3DSA:3.30.470.20 202 446 8.6E-90 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 SUPERFAMILY SSF56059 114 321 1.2E-58 T 17-03-2017 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Pfam PF00364 Biotin-requiring enzyme 515 580 9.6E-18 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 285 292 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 537 554 - T 17-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Gene3D G3DSA:2.40.50.100 512 581 9.8E-23 T 17-03-2017 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Pfam PF00289 Biotin carboxylase, N-terminal domain 2 109 2.1E-43 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Gene3D G3DSA:3.30.1490.20 129 201 3.5E-21 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 SUPERFAMILY SSF51246 328 444 1.26E-36 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 SUPERFAMILY SSF52440 2 112 7.19E-46 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 114 319 3.8E-75 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS15110 f773d19f541ae02b0a8f88ad1ba3392e 582 SUPERFAMILY SSF51230 509 580 1.01E-19 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 Gene3D G3DSA:1.10.1660.10 2 113 1.3E-27 T 17-03-2017 SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 SUPERFAMILY SSF46955 2 114 6.96E-25 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 SMART SM00422 1 69 2.8E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 Pfam PF13411 MerR HTH family regulatory protein 2 66 5.7E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 1.1E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 1.1E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS22705 efdd24d813fb81428a3c29845f052820 125 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 1.1E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS06785 282bb9ac36eecbe9208dc1ae387a1afc 205 Pfam PF06684 Amino acid synthesis 6 182 3.0E-61 T 17-03-2017 IPR009569 Amino acid synthesis, putative SHXM_RS06785 282bb9ac36eecbe9208dc1ae387a1afc 205 SUPERFAMILY SSF160519 4 189 1.96E-59 T 17-03-2017 IPR009569 Amino acid synthesis, putative SHXM_RS06785 282bb9ac36eecbe9208dc1ae387a1afc 205 Gene3D G3DSA:3.30.1330.110 2 187 1.5E-66 T 17-03-2017 IPR009569 Amino acid synthesis, putative SHXM_RS11190 f8609d81c6eb00aaef0c1fa11585be99 275 SUPERFAMILY SSF52540 15 237 2.03E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11190 f8609d81c6eb00aaef0c1fa11585be99 275 SMART SM00382 41 227 3.0E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS11190 f8609d81c6eb00aaef0c1fa11585be99 275 ProSitePatterns PS00211 ABC transporters family signature. 140 154 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS11190 f8609d81c6eb00aaef0c1fa11585be99 275 Pfam PF00005 ABC transporter 34 168 5.6E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS11190 f8609d81c6eb00aaef0c1fa11585be99 275 Gene3D G3DSA:3.40.50.300 9 226 1.3E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15895 bfe57862237d9257b420c162e02532d3 453 PIRSF PIRSF018077 1 453 5.7E-180 T 17-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 SHXM_RS15895 bfe57862237d9257b420c162e02532d3 453 TIGRFAM TIGR03686 pupylate_PafA: Pup--protein ligase 3 453 3.8E-230 T 17-03-2017 IPR022279 Pup--protein ligase GO:0010498|GO:0016879|GO:0019941 SHXM_RS15895 bfe57862237d9257b420c162e02532d3 453 Pfam PF03136 Pup-ligase protein 4 423 3.1E-156 T 17-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 SHXM_RS15895 bfe57862237d9257b420c162e02532d3 453 Hamap MF_02111 Pup--protein ligase [pafA]. 1 453 50.147 T 17-03-2017 IPR022279 Pup--protein ligase GO:0010498|GO:0016879|GO:0019941 SHXM_RS22770 fa14ed61dc2087c92bb033e504e33995 444 Pfam PF13416 Bacterial extracellular solute-binding protein 67 375 1.9E-28 T 17-03-2017 SHXM_RS22770 fa14ed61dc2087c92bb033e504e33995 444 SUPERFAMILY SSF53850 51 439 1.71E-46 T 17-03-2017 SHXM_RS22770 fa14ed61dc2087c92bb033e504e33995 444 Gene3D G3DSA:3.40.190.10 181 370 8.7E-25 T 17-03-2017 SHXM_RS22770 fa14ed61dc2087c92bb033e504e33995 444 Gene3D G3DSA:3.40.190.10 60 180 3.1E-12 T 17-03-2017 SHXM_RS35400 bda1062f555a1a8eee0173d80586f227 316 Pfam PF03253 Urea transporter 23 299 1.9E-76 T 17-03-2017 IPR004937 Urea transporter GO:0015204|GO:0016021|GO:0071918 Reactome: R-HSA-425366 SHXM_RS35400 bda1062f555a1a8eee0173d80586f227 316 Gene3D G3DSA:1.10.3430.10 15 302 2.2E-76 T 17-03-2017 IPR029020 Ammonium/urea transporter SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 SUPERFAMILY SSF53850 145 313 3.98E-14 T 17-03-2017 SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 Pfam PF03466 LysR substrate binding domain 145 307 1.6E-13 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 Gene3D G3DSA:1.10.10.10 20 101 9.4E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 21 79 1.2E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 Gene3D G3DSA:3.40.190.10 197 285 5.0E-8 T 17-03-2017 SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 Gene3D G3DSA:3.40.190.10 146 196 2.5E-11 T 17-03-2017 SHXM_RS41190 621df417ed2259c3b5012647246a6d23 324 SUPERFAMILY SSF46785 20 100 1.4E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Gene3D G3DSA:2.70.98.10 410 704 1.3E-75 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Pfam PF00754 F5/8 type C domain 100 217 6.8E-12 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Gene3D G3DSA:2.60.120.260 99 225 7.6E-14 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 SUPERFAMILY SSF48208 644 1130 6.46E-16 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Pfam PF07971 Glycosyl hydrolase family 92 621 1147 3.7E-140 T 17-03-2017 IPR012939 Glycosyl hydrolase family 92 SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Gene3D G3DSA:1.20.1610.10 840 1009 3.0E-47 T 17-03-2017 SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 412 1150 2.6E-139 T 17-03-2017 IPR005887 Alpha-1,2-mannosidase, putative SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 SUPERFAMILY SSF49785 106 215 8.22E-14 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Gene3D G3DSA:1.20.1050.60 748 836 1.9E-29 T 17-03-2017 SHXM_RS38160 fa6796ce48c991ad6fc19d3d10bb35cd 1286 Gene3D G3DSA:3.30.2080.10 1010 1159 3.7E-58 T 17-03-2017 SHXM_RS30775 fa661082b564d4761b1f378dc6824c0c 269 Gene3D G3DSA:3.40.30.10 85 172 4.9E-10 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS30775 fa661082b564d4761b1f378dc6824c0c 269 SUPERFAMILY SSF52833 17 174 5.7E-49 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS30775 fa661082b564d4761b1f378dc6824c0c 269 Pfam PF01257 Thioredoxin-like [2Fe-2S] ferredoxin 22 164 9.9E-51 T 17-03-2017 SHXM_RS30775 fa661082b564d4761b1f378dc6824c0c 269 TIGRFAM TIGR01958 nuoE_fam: NADH-quinone oxidoreductase, E subunit 22 164 2.1E-44 T 17-03-2017 IPR002023 NADH-quinone oxidoreductase subunit E-like GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30775 fa661082b564d4761b1f378dc6824c0c 269 ProSitePatterns PS01099 Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. 122 140 - T 17-03-2017 IPR002023 NADH-quinone oxidoreductase subunit E-like GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS12130 8d2076730077538357d5099db737781b 457 Gene3D G3DSA:3.10.580.10 213 350 1.7E-17 T 17-03-2017 SHXM_RS12130 8d2076730077538357d5099db737781b 457 SUPERFAMILY SSF54631 215 351 9.73E-25 T 17-03-2017 SHXM_RS12130 8d2076730077538357d5099db737781b 457 Pfam PF03471 Transporter associated domain 364 436 2.1E-13 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS12130 8d2076730077538357d5099db737781b 457 SUPERFAMILY SSF56176 364 439 1.64E-14 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS12130 8d2076730077538357d5099db737781b 457 Gene3D G3DSA:3.30.465.10 360 441 5.5E-18 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS12130 8d2076730077538357d5099db737781b 457 Pfam PF00571 CBS domain 223 275 0.0023 T 17-03-2017 IPR000644 CBS domain SHXM_RS12130 8d2076730077538357d5099db737781b 457 Pfam PF00571 CBS domain 291 339 6.0E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS12130 8d2076730077538357d5099db737781b 457 Pfam PF01595 Domain of unknown function DUF21 13 204 1.9E-37 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS12130 8d2076730077538357d5099db737781b 457 SMART SM01091 361 438 1.3E-16 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 Pfam PF07969 Amidohydrolase family 48 542 8.0E-67 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 Gene3D G3DSA:2.30.40.10 3 71 2.4E-17 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 SUPERFAMILY SSF51338 2 57 4.03E-20 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 SUPERFAMILY SSF51338 499 566 4.03E-20 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 SUPERFAMILY SSF51556 58 315 2.21E-53 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 SUPERFAMILY SSF51556 371 499 2.21E-53 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 Gene3D G3DSA:3.20.20.140 72 307 2.3E-81 T 17-03-2017 SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 Gene3D G3DSA:3.20.20.140 424 485 2.3E-81 T 17-03-2017 SHXM_RS31855 b6e49ca9c9fea619a096052e4407b6f4 580 Gene3D G3DSA:2.30.40.10 486 568 2.0E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12520 c3eb98da3211cc17a22ab35cbafb3853 176 Pfam PF00156 Phosphoribosyl transferase domain 42 150 1.3E-14 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS12520 c3eb98da3211cc17a22ab35cbafb3853 176 Gene3D G3DSA:3.40.50.2020 4 164 4.9E-61 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS12520 c3eb98da3211cc17a22ab35cbafb3853 176 SUPERFAMILY SSF53271 8 164 3.41E-47 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS12520 c3eb98da3211cc17a22ab35cbafb3853 176 TIGRFAM TIGR01090 apt: adenine phosphoribosyltransferase 6 165 1.8E-59 T 17-03-2017 IPR005764 Adenine phosphoribosyl transferase GO:0003999|GO:0005737|GO:0006168 KEGG: 00230+2.4.2.7|MetaCyc: PWY-6605|MetaCyc: PWY-6610|Reactome: R-HSA-74217 SHXM_RS12520 c3eb98da3211cc17a22ab35cbafb3853 176 Hamap MF_00004 Adenine phosphoribosyltransferase [apt]. 5 176 35.547 T 17-03-2017 IPR005764 Adenine phosphoribosyl transferase GO:0003999|GO:0005737|GO:0006168 KEGG: 00230+2.4.2.7|MetaCyc: PWY-6605|MetaCyc: PWY-6610|Reactome: R-HSA-74217 SHXM_RS47880 27a4cabaed6245e182fd33d259527493 135 Gene3D G3DSA:2.60.120.10 4 129 7.3E-28 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS47880 27a4cabaed6245e182fd33d259527493 135 SUPERFAMILY SSF51182 10 132 5.64E-25 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS47880 27a4cabaed6245e182fd33d259527493 135 Pfam PF07883 Cupin domain 39 98 6.7E-8 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 Gene3D G3DSA:1.10.560.10 6 194 6.9E-48 T 17-03-2017 IPR027413 GroEL-like equatorial domain SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 Gene3D G3DSA:1.10.560.10 369 515 2.2E-40 T 17-03-2017 IPR027413 GroEL-like equatorial domain SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 PRINTS PR00298 60kDa chaperonin signature 26 52 3.8E-70 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 PRINTS PR00298 60kDa chaperonin signature 82 109 3.8E-70 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 PRINTS PR00298 60kDa chaperonin signature 266 289 3.8E-70 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 PRINTS PR00298 60kDa chaperonin signature 348 373 3.8E-70 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 PRINTS PR00298 60kDa chaperonin signature 396 417 3.8E-70 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 Pfam PF00118 TCP-1/cpn60 chaperonin family 22 522 5.6E-97 T 17-03-2017 IPR002423 Chaperonin Cpn60/TCP-1 family GO:0005524 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 SUPERFAMILY SSF52029 184 374 1.41E-83 T 17-03-2017 IPR027409 GroEL-like apical domain SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 Gene3D G3DSA:3.50.7.10 195 368 2.3E-93 T 17-03-2017 IPR027409 GroEL-like apical domain SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 SUPERFAMILY SSF54849 137 201 9.39E-27 T 17-03-2017 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 ProSitePatterns PS00296 Chaperonins cpn60 signature. 403 414 - T 17-03-2017 IPR018370 Chaperonin Cpn60, conserved site GO:0005524|GO:0005737|GO:0006457 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 Hamap MF_00600 60 kDa chaperonin [groL]. 1 539 41.753 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 SUPERFAMILY SSF48592 6 133 8.33E-75 T 17-03-2017 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 SUPERFAMILY SSF48592 404 518 8.33E-75 T 17-03-2017 SHXM_RS25845 d5f61831e6b4cc8f68b0ee0403a09624 541 TIGRFAM TIGR02348 GroEL: chaperonin GroL 2 524 6.0E-251 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 SUPERFAMILY SSF63380 233 328 8.6E-16 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 Gene3D G3DSA:3.40.50.80 321 448 1.3E-30 T 17-03-2017 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 Gene3D G3DSA:2.40.30.10 234 320 8.1E-14 T 17-03-2017 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 PRINTS PR00409 Phthalate dioxygenase reductase family signature 420 428 6.4E-7 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 PRINTS PR00409 Phthalate dioxygenase reductase family signature 302 316 6.4E-7 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 PRINTS PR00409 Phthalate dioxygenase reductase family signature 339 358 6.4E-7 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 SUPERFAMILY SSF52343 319 450 1.24E-29 T 17-03-2017 SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 Pfam PF01794 Ferric reductase like transmembrane component 66 187 6.2E-14 T 17-03-2017 IPR013130 Ferric reductase transmembrane component-like domain SHXM_RS43040 eee32ce16f090e3997b05dd2e754a659 454 Pfam PF00175 Oxidoreductase NAD-binding domain 340 434 4.3E-11 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 Pfam PF04542 Sigma-70 region 2 7 68 5.5E-13 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 Gene3D G3DSA:1.10.1740.10 6 67 3.5E-11 T 17-03-2017 SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 Gene3D G3DSA:3.10.450.50 165 281 3.5E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 Gene3D G3DSA:1.10.10.10 101 156 1.0E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 155 1.2E-15 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 Pfam PF08281 Sigma-70, region 4 102 153 1.5E-10 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 TIGRFAM TIGR02957 SigX4: RNA polymerase sigma-70 factor, TIGR02957 family 6 282 9.3E-103 T 17-03-2017 IPR014303 RNA polymerase sigma-70, ECF type SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 Pfam PF12680 SnoaL-like domain 174 269 4.0E-7 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 SUPERFAMILY SSF54427 169 282 2.93E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 SUPERFAMILY SSF88946 7 83 2.86E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35935 12a1b025f5e31461330090afb5eb4922 284 SUPERFAMILY SSF88659 75 157 3.05E-10 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 SUPERFAMILY SSF102114 36 308 8.63E-63 T 17-03-2017 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 SMART SM00729 72 278 2.7E-14 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 TIGRFAM TIGR00510 lipA: lipoyl synthase 18 306 3.3E-100 T 17-03-2017 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 PIRSF PIRSF005963 3 315 1.6E-123 T 17-03-2017 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 Hamap MF_00206 Lipoyl synthase [lipA]. 1 308 138.781 T 17-03-2017 IPR003698 Lipoyl synthase GO:0009107|GO:0016992|GO:0051539 KEGG: 00785+2.8.1.8|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 Pfam PF04055 Radical SAM superfamily 82 236 4.5E-12 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS19085 b4407b1ae9e051832918923d18c0255d 316 Gene3D G3DSA:3.20.20.70 39 302 1.8E-67 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 SMART SM00342 226 312 1.1E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 281 296 3.1E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 296 312 3.1E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 Pfam PF12833 Helix-turn-helix domain 232 313 1.0E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 SUPERFAMILY SSF46689 261 316 2.28E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 Gene3D G3DSA:1.10.10.60 262 314 2.9E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50590 6165014eb9cbc1c49fd8d2678226f6e5 330 Gene3D G3DSA:1.10.10.60 209 261 1.4E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 SUPERFAMILY SSF55073 188 334 1.8E-28 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 181 335 7.1E-24 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 Pfam PF00990 Diguanylate cyclase, GGDEF domain 183 335 2.6E-25 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 SMART SM00065 6 180 0.0035 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 Gene3D G3DSA:3.30.70.270 185 335 2.2E-32 T 17-03-2017 SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 Pfam PF01590 GAF domain 114 165 8.5E-5 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 SUPERFAMILY SSF55781 11 173 4.14E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 Gene3D G3DSA:3.30.450.40 4 177 1.9E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS24655 3f6a7728d22e47363eca98b316f21afd 373 SMART SM00267 172 342 7.7E-43 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 SUPERFAMILY SSF81338 7 252 1.31E-59 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 PRINTS PR00783 Major intrinsic protein family signature 47 71 4.5E-42 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 PRINTS PR00783 Major intrinsic protein family signature 233 253 4.5E-42 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 PRINTS PR00783 Major intrinsic protein family signature 5 24 4.5E-42 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 PRINTS PR00783 Major intrinsic protein family signature 141 159 4.5E-42 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 PRINTS PR00783 Major intrinsic protein family signature 83 102 4.5E-42 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 PRINTS PR00783 Major intrinsic protein family signature 186 208 4.5E-42 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 Gene3D G3DSA:1.20.1080.10 7 252 7.6E-76 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 ProSitePatterns PS00221 MIP family signature. 65 73 - T 17-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS43815 d5d9be0a21e5dfcb2998544f0d2f5347 254 Pfam PF00230 Major intrinsic protein 8 250 1.6E-39 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 Gene3D G3DSA:1.20.1560.10 26 327 1.0E-34 T 17-03-2017 SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 SUPERFAMILY SSF90123 20 328 1.07E-44 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 Gene3D G3DSA:3.40.50.300 431 602 1.6E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 SUPERFAMILY SSF52540 413 597 1.83E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 Pfam PF00664 ABC transporter transmembrane region 42 302 5.8E-22 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 Pfam PF00005 ABC transporter 480 529 5.8E-11 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45175 a003a47aaaaa006758b0d76fbc43b464 630 ProSitePatterns PS00211 ABC transporters family signature. 501 515 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 Gene3D G3DSA:3.30.300.30 259 339 2.3E-5 T 17-03-2017 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 Pfam PF00501 AMP-binding enzyme 52 179 1.0E-23 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 Pfam PF00501 AMP-binding enzyme 200 261 3.6E-16 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 Gene3D G3DSA:3.40.50.980 44 171 1.4E-20 T 17-03-2017 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 SUPERFAMILY SSF56801 42 180 1.7E-26 T 17-03-2017 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 Gene3D G3DSA:2.30.38.10 199 255 7.9E-16 T 17-03-2017 SHXM_RS48895 4ee7ff5e27ff64641b8c250ee309427f 370 SUPERFAMILY SSF56801 186 323 2.62E-29 T 17-03-2017 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 TIGRFAM TIGR00326 eubact_ribD: riboflavin biosynthesis protein RibD 10 354 3.6E-113 T 17-03-2017 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 54 92 - T 17-03-2017 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 Gene3D G3DSA:3.40.140.10 7 132 2.7E-27 T 17-03-2017 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 Pfam PF01872 RibD C-terminal domain 150 353 8.1E-49 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 SUPERFAMILY SSF53927 8 148 1.66E-41 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 8 103 8.2E-17 T 17-03-2017 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 Gene3D G3DSA:3.40.430.10 133 359 1.4E-74 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 PIRSF PIRSF006769 2 361 1.3E-124 T 17-03-2017 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 TIGRFAM TIGR00227 ribD_Cterm: riboflavin-specific deaminase C-terminal domain 149 358 7.1E-56 T 17-03-2017 IPR011549 Riboflavin-specific deaminase, C-terminal GO:0008703|GO:0009231|GO:0050661|GO:0055114 SHXM_RS12165 754548e077828b82e1c46786c247cbf4 369 SUPERFAMILY SSF53597 148 356 5.89E-57 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS28965 f4ad1497337eff879ec897131dc1e01a 412 SMART SM00331 185 401 4.5E-21 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28965 f4ad1497337eff879ec897131dc1e01a 412 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 211 401 9.3E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28965 f4ad1497337eff879ec897131dc1e01a 412 SUPERFAMILY SSF81606 199 401 4.97E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 SUPERFAMILY SSF51735 13 213 1.05E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 SUPERFAMILY SSF51735 317 378 1.05E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 SUPERFAMILY SSF55347 214 318 8.37E-28 T 17-03-2017 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 Pfam PF07994 Myo-inositol-1-phosphate synthase 17 158 1.3E-7 T 17-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 Pfam PF07994 Myo-inositol-1-phosphate synthase 161 356 2.4E-18 T 17-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 PIRSF PIRSF015578 7 368 2.8E-85 T 17-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 Pfam PF01658 Myo-inositol-1-phosphate synthase 215 319 5.6E-24 T 17-03-2017 IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 Gene3D G3DSA:3.30.360.10 216 314 4.0E-27 T 17-03-2017 SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 Gene3D G3DSA:3.40.50.720 17 215 8.6E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14175 60def533fb9d35c54bc403bdd4cc589a 380 Gene3D G3DSA:3.40.50.720 318 374 8.6E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41820 bf9be1ed5d3bd0c4c66e9f380f96d286 227 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 66 9.8E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41820 bf9be1ed5d3bd0c4c66e9f380f96d286 227 SUPERFAMILY SSF46689 10 85 2.18E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41820 bf9be1ed5d3bd0c4c66e9f380f96d286 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 1.2E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41820 bf9be1ed5d3bd0c4c66e9f380f96d286 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 43 66 1.2E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41820 bf9be1ed5d3bd0c4c66e9f380f96d286 227 Gene3D G3DSA:1.10.357.10 8 176 2.7E-18 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS24970 6fea349a98c3298ee853f00ca8f9fbc8 477 Gene3D G3DSA:3.40.50.10540 224 417 1.2E-68 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS24970 6fea349a98c3298ee853f00ca8f9fbc8 477 Pfam PF02515 CoA-transferase family III 225 417 4.3E-47 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS24970 6fea349a98c3298ee853f00ca8f9fbc8 477 SUPERFAMILY SSF89796 14 200 4.71E-14 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS24970 6fea349a98c3298ee853f00ca8f9fbc8 477 SUPERFAMILY SSF89796 222 433 1.44E-58 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS24970 6fea349a98c3298ee853f00ca8f9fbc8 477 Gene3D G3DSA:3.40.50.10540 38 154 4.5E-5 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS29135 71e5be8e8e8c74438b5188af3628bd16 393 Gene3D G3DSA:3.90.1150.10 277 389 1.7E-20 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS29135 71e5be8e8e8c74438b5188af3628bd16 393 Gene3D G3DSA:3.40.640.10 46 276 5.2E-82 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS29135 71e5be8e8e8c74438b5188af3628bd16 393 Pfam PF00155 Aminotransferase class I and II 33 387 1.7E-67 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS29135 71e5be8e8e8c74438b5188af3628bd16 393 SUPERFAMILY SSF53383 8 389 1.73E-109 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS05300 2c9f005e5ee88eb439fb724d61ace37e 195 SMART SM00823 Phosphopantetheine attachment site 128 195 1.8E-24 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05300 2c9f005e5ee88eb439fb724d61ace37e 195 SMART SM01294 129 195 0.0035 T 17-03-2017 SHXM_RS05300 2c9f005e5ee88eb439fb724d61ace37e 195 SUPERFAMILY SSF47336 121 195 6.81E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05300 2c9f005e5ee88eb439fb724d61ace37e 195 Pfam PF00550 Phosphopantetheine attachment site 130 195 2.3E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05300 2c9f005e5ee88eb439fb724d61ace37e 195 ProSitePatterns PS00012 Phosphopantetheine attachment site. 155 170 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05300 2c9f005e5ee88eb439fb724d61ace37e 195 Gene3D G3DSA:1.10.1200.10 125 195 1.9E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 Pfam PF04542 Sigma-70 region 2 44 108 5.6E-14 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 Pfam PF08281 Sigma-70, region 4 141 191 1.9E-13 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 39 193 1.2E-19 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 SUPERFAMILY SSF88659 139 195 2.83E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 SUPERFAMILY SSF88946 22 124 1.1E-22 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 Gene3D G3DSA:1.10.10.10 141 196 3.5E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05070 f5cf16417b3a457e57d78300757889bb 210 Gene3D G3DSA:1.10.1740.10 28 128 7.6E-23 T 17-03-2017 SHXM_RS29560 aa041cbd38aeed5a1f4a752ed9d11e29 403 Pfam PF00589 Phage integrase family 219 386 3.1E-22 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS29560 aa041cbd38aeed5a1f4a752ed9d11e29 403 SUPERFAMILY SSF56349 71 129 6.77E-64 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS29560 aa041cbd38aeed5a1f4a752ed9d11e29 403 SUPERFAMILY SSF56349 157 395 6.77E-64 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS29560 aa041cbd38aeed5a1f4a752ed9d11e29 403 Pfam PF14659 Phage integrase, N-terminal SAM-like domain 71 127 5.1E-13 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS29560 aa041cbd38aeed5a1f4a752ed9d11e29 403 Gene3D G3DSA:1.10.443.10 211 395 9.6E-42 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS29560 aa041cbd38aeed5a1f4a752ed9d11e29 403 Gene3D G3DSA:1.10.150.130 71 193 5.4E-16 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 SUPERFAMILY SSF46689 2 66 3.36E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 Gene3D G3DSA:1.10.357.10 45 179 9.3E-34 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 Pfam PF00440 Bacterial regulatory proteins, tetR family 5 48 7.1E-18 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 Gene3D G3DSA:1.10.10.60 2 44 8.3E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 ProSitePatterns PS01081 TetR-type HTH domain signature. 17 48 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 49 4.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10615 932a39bf6f8d96eaa3487c7e15e34091 228 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 5 18 4.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14665 a68c703116de4b58293a7bc5e5729fd7 681 SUPERFAMILY SSF82171 87 382 7.06E-12 T 17-03-2017 SHXM_RS14665 a68c703116de4b58293a7bc5e5729fd7 681 Gene3D G3DSA:2.120.10.30 174 268 1.2E-6 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS14665 a68c703116de4b58293a7bc5e5729fd7 681 Gene3D G3DSA:3.40.50.1820 361 650 4.5E-61 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14665 a68c703116de4b58293a7bc5e5729fd7 681 Pfam PF00326 Prolyl oligopeptidase family 452 656 4.8E-41 T 17-03-2017 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SHXM_RS14665 a68c703116de4b58293a7bc5e5729fd7 681 SUPERFAMILY SSF53474 403 649 2.23E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS36830 05c13d35b057a32c66157d8dd0fc29d8 560 Gene3D G3DSA:3.40.190.10 238 426 3.1E-24 T 17-03-2017 SHXM_RS36830 05c13d35b057a32c66157d8dd0fc29d8 560 Gene3D G3DSA:3.40.190.10 509 555 3.1E-24 T 17-03-2017 SHXM_RS36830 05c13d35b057a32c66157d8dd0fc29d8 560 SUPERFAMILY SSF53850 107 555 5.73E-58 T 17-03-2017 SHXM_RS36830 05c13d35b057a32c66157d8dd0fc29d8 560 Gene3D G3DSA:3.40.190.10 132 237 1.1E-5 T 17-03-2017 SHXM_RS36830 05c13d35b057a32c66157d8dd0fc29d8 560 Pfam PF13416 Bacterial extracellular solute-binding protein 124 423 3.5E-15 T 17-03-2017 SHXM_RS08645 fcf0a90e139a21534b09db27bf37437d 529 SUPERFAMILY SSF56300 149 522 2.62E-38 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS08645 fcf0a90e139a21534b09db27bf37437d 529 Gene3D G3DSA:3.60.21.10 148 524 2.7E-35 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS08645 fcf0a90e139a21534b09db27bf37437d 529 Pfam PF09423 PhoD-like phosphatase 161 508 9.1E-78 T 17-03-2017 IPR018946 Alkaline phosphatase D-related SHXM_RS08645 fcf0a90e139a21534b09db27bf37437d 529 Pfam PF16655 PhoD-like phosphatase, N-terminal domain 54 144 4.3E-14 T 17-03-2017 IPR032093 Phospholipase D, N-terminal SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 Pfam PF00486 Transcriptional regulatory protein, C terminal 161 236 2.5E-27 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 Gene3D G3DSA:1.10.10.10 162 239 1.6E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 Gene3D G3DSA:3.40.50.2300 6 161 4.3E-46 T 17-03-2017 SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 SMART SM00862 161 236 1.1E-29 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 SMART SM00448 8 118 1.1E-47 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 SUPERFAMILY SSF46894 144 236 1.42E-28 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 SUPERFAMILY SSF52172 5 127 2.28E-44 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS38360 a3f2c008c4ce2f215e6b094043bb5042 279 Pfam PF00072 Response regulator receiver domain 10 118 6.6E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 Gene3D G3DSA:1.10.357.10 29 221 2.4E-46 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 ProSitePatterns PS01081 TetR-type HTH domain signature. 58 88 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 SUPERFAMILY SSF48498 113 223 1.89E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 67 90 2.3E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 59 2.3E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 SUPERFAMILY SSF46689 31 111 1.28E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS32770 8bda5833914eec1698d33f548473bb86 236 Pfam PF00440 Bacterial regulatory proteins, tetR family 46 90 4.6E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38575 734ef9b9e407ae830c746939623b7473 313 Gene3D G3DSA:3.40.50.720 1 298 1.7E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38575 734ef9b9e407ae830c746939623b7473 313 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 226 2.6E-15 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS38575 734ef9b9e407ae830c746939623b7473 313 SUPERFAMILY SSF51735 1 297 1.57E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 305 332 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 149 165 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 354 363 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 207 229 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 333 348 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 166 181 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 287 298 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 363 374 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 PRINTS PR00359 B-class P450 signature 103 114 8.0E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 Pfam PF00067 Cytochrome P450 217 383 5.0E-22 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 SUPERFAMILY SSF48264 14 417 4.98E-91 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 356 365 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS42970 7ffd43f707618709bb1cbdc0df5ffdcf 418 Gene3D G3DSA:1.10.630.10 10 416 8.2E-120 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 SUPERFAMILY SSF47323 586 823 2.24E-51 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 SUPERFAMILY SSF46589 810 874 1.57E-14 T 17-03-2017 IPR010978 tRNA-binding arm GO:0000166 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Gene3D G3DSA:3.40.50.620 355 572 1.3E-136 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Gene3D G3DSA:3.40.50.620 22 210 1.3E-136 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 SUPERFAMILY SSF52374 355 584 1.21E-133 T 17-03-2017 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 SUPERFAMILY SSF52374 18 209 1.21E-133 T 17-03-2017 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Gene3D G3DSA:3.90.740.10 211 348 2.0E-43 T 17-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Pfam PF10458 Valyl tRNA synthetase tRNA binding arm 810 874 1.7E-17 T 17-03-2017 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Pfam PF08264 Anticodon-binding domain of tRNA 616 757 1.5E-38 T 17-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Hamap MF_02004 Valine--tRNA ligase [valS]. 19 875 15.193 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Gene3D G3DSA:1.10.730.10 575 749 6.0E-57 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Gene3D G3DSA:1.10.287.380 803 874 5.8E-9 T 17-03-2017 IPR019499 Valyl-tRNA synthetase, tRNA-binding arm GO:0000166|GO:0004832|GO:0005524|GO:0005737|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 TIGRFAM TIGR00422 valS: valine--tRNA ligase 20 854 0.0 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 PRINTS PR00986 Valyl-tRNA synthetase signature 485 503 2.4E-37 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 PRINTS PR00986 Valyl-tRNA synthetase signature 53 64 2.4E-37 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 PRINTS PR00986 Valyl-tRNA synthetase signature 454 475 2.4E-37 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 PRINTS PR00986 Valyl-tRNA synthetase signature 245 262 2.4E-37 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 PRINTS PR00986 Valyl-tRNA synthetase signature 360 373 2.4E-37 T 17-03-2017 IPR002303 Valine-tRNA ligase GO:0000166|GO:0004832|GO:0005524|GO:0006438 KEGG: 00970+6.1.1.9 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 32 570 8.0E-187 T 17-03-2017 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 60 71 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21675 c8d516ec214a93703c73e887ea62e20b 877 SUPERFAMILY SSF50677 209 348 7.06E-52 T 17-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 Gene3D G3DSA:1.10.150.120 90 167 2.5E-34 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 Gene3D G3DSA:3.10.20.30 15 89 4.9E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 SUPERFAMILY SSF54292 12 102 3.41E-27 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 SUPERFAMILY SSF47741 99 165 5.5E-31 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 54 62 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 Pfam PF01799 [2Fe-2S] binding domain 88 160 4.7E-31 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS47985 2b2abc357606840cda319781c086fcaa 170 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 22 77 1.6E-7 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS10925 952e48c9b5f470a325e0b9b3cdf753a2 366 Pfam PF00296 Luciferase-like monooxygenase 17 328 2.9E-64 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS10925 952e48c9b5f470a325e0b9b3cdf753a2 366 Gene3D G3DSA:3.20.20.30 291 362 2.3E-85 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS10925 952e48c9b5f470a325e0b9b3cdf753a2 366 Gene3D G3DSA:3.20.20.30 3 252 2.3E-85 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS10925 952e48c9b5f470a325e0b9b3cdf753a2 366 SUPERFAMILY SSF51679 4 359 4.71E-73 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00385 P450 superfamily signature 268 285 1.3E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00385 P450 superfamily signature 369 378 1.3E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00385 P450 superfamily signature 378 389 1.3E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00385 P450 superfamily signature 303 314 1.3E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 371 380 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 Pfam PF00067 Cytochrome P450 303 398 5.0E-21 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00359 B-class P450 signature 303 314 7.1E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00359 B-class P450 signature 348 363 7.1E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00359 B-class P450 signature 378 389 7.1E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00359 B-class P450 signature 320 347 7.1E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00359 B-class P450 signature 369 378 7.1E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 PRINTS PR00359 B-class P450 signature 94 105 7.1E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 Gene3D G3DSA:1.10.630.10 209 426 3.0E-110 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 Gene3D G3DSA:1.10.630.10 14 174 3.0E-110 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 SUPERFAMILY SSF48264 16 174 3.41E-82 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS07110 3b91c30b152b49ba43ad592776eaaa47 430 SUPERFAMILY SSF48264 210 426 3.41E-82 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 ProSitePatterns PS00217 Sugar transport proteins signature 2. 122 147 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 PRINTS PR00171 Sugar transporter signature 377 398 1.5E-22 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 PRINTS PR00171 Sugar transporter signature 34 44 1.5E-22 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 PRINTS PR00171 Sugar transporter signature 117 136 1.5E-22 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 PRINTS PR00171 Sugar transporter signature 400 412 1.5E-22 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 PRINTS PR00171 Sugar transporter signature 284 294 1.5E-22 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 21 471 1.7E-99 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 SUPERFAMILY SSF103473 22 471 3.4E-71 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 ProSitePatterns PS00216 Sugar transport proteins signature 1. 328 345 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 Gene3D G3DSA:1.20.1250.20 274 470 1.7E-20 T 17-03-2017 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 Gene3D G3DSA:1.20.1250.20 29 224 8.0E-25 T 17-03-2017 SHXM_RS36490 08ff74b84d9f667fe3e66095a34e8b1f 472 Pfam PF00083 Sugar (and other) transporter 27 471 6.6E-103 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 SMART SM00862 162 233 1.8E-24 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 SMART SM00448 4 114 2.9E-40 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 Gene3D G3DSA:1.10.10.10 141 234 1.9E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 SUPERFAMILY SSF46894 139 233 1.93E-27 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 Pfam PF00072 Response regulator receiver domain 6 115 1.2E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 Pfam PF00486 Transcriptional regulatory protein, C terminal 162 233 6.7E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 Gene3D G3DSA:3.40.50.2300 4 120 1.2E-38 T 17-03-2017 SHXM_RS30270 0a3d3db0438f5da5a25aa2bea7743460 235 SUPERFAMILY SSF52172 4 123 9.68E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 SUPERFAMILY SSF50621 302 462 1.09E-48 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 SUPERFAMILY SSF51419 63 328 5.38E-78 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 267 280 - T 17-03-2017 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 113 125 3.3E-17 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 419 432 3.3E-17 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 317 336 3.3E-17 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 93 111 3.3E-17 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 228 241 3.3E-17 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 Hamap MF_02120 Diaminopimelate decarboxylase [lysA]. 52 462 39.606 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 200 209 1.9E-24 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 111 128 1.9E-24 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 346 364 1.9E-24 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 PRINTS PR01181 Diaminopimelate decarboxylase signature 429 451 1.9E-24 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 Gene3D G3DSA:3.20.20.10 72 314 1.6E-93 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 71 327 1.6E-64 T 17-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 Gene3D G3DSA:2.40.37.10 315 462 1.1E-47 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 ProSitePatterns PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 93 111 - T 17-03-2017 IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 TIGRFAM TIGR01048 lysA: diaminopimelate decarboxylase 43 461 1.4E-142 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS35160 96839e4c46fb0878e731a26e521995cf 463 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 335 438 4.2E-15 T 17-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 SUPERFAMILY SSF51726 12 403 2.75E-102 T 17-03-2017 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 Pfam PF01717 Cobalamin-independent synthase, Catalytic domain 441 763 2.6E-142 T 17-03-2017 IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 Gene3D G3DSA:3.20.20.210 12 400 3.2E-139 T 17-03-2017 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 Hamap MF_00172 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [metE]. 10 768 34.985 T 17-03-2017 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 TIGRFAM TIGR01371 met_syn_B12ind: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase 16 767 0.0 T 17-03-2017 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 Pfam PF08267 Cobalamin-independent synthase, N-terminal domain 13 323 1.9E-114 T 17-03-2017 IPR013215 Cobalamin-independent methionine synthase MetE, N-terminal GO:0003871|GO:0008270|GO:0008652 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 Gene3D G3DSA:3.20.20.210 403 769 3.9E-124 T 17-03-2017 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 SUPERFAMILY SSF51726 406 767 1.02E-108 T 17-03-2017 SHXM_RS42270 53a24376bbc33b61e2f2d80b71a72421 772 PIRSF PIRSF000382 9 772 0.0 T 17-03-2017 IPR006276 Cobalamin-independent methionine synthase GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 PRINTS PR00084 Mannitol dehydrogenase signature 222 235 6.6E-14 T 17-03-2017 IPR000669 Mannitol dehydrogenase GO:0003824|GO:0008152|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 PRINTS PR00084 Mannitol dehydrogenase signature 29 39 6.6E-14 T 17-03-2017 IPR000669 Mannitol dehydrogenase GO:0003824|GO:0008152|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 PRINTS PR00084 Mannitol dehydrogenase signature 252 267 6.6E-14 T 17-03-2017 IPR000669 Mannitol dehydrogenase GO:0003824|GO:0008152|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 Pfam PF08125 Mannitol dehydrogenase C-terminal domain 221 414 1.8E-58 T 17-03-2017 IPR013118 Mannitol dehydrogenase, C-terminal GO:0016491|GO:0050662|GO:0055114 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 Gene3D G3DSA:1.10.1040.10 286 492 2.7E-47 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 SUPERFAMILY SSF51735 17 286 7.48E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 Gene3D G3DSA:3.40.50.720 22 285 1.1E-92 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 ProSitePatterns PS00974 Mannitol dehydrogenases signature. 222 234 - T 17-03-2017 IPR023027 Mannitol dehydrogenase, conserved site GO:0019594|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 SUPERFAMILY SSF48179 287 493 2.48E-39 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS05960 893e6466028dc37a63fb50dbee753d3b 505 Pfam PF01232 Mannitol dehydrogenase Rossmann domain 28 188 1.0E-29 T 17-03-2017 IPR013131 Mannitol dehydrogenase, N-terminal GO:0016491|GO:0055114 SHXM_RS35185 59e8bb860efe96c3114d3d86f5c3f7e5 374 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 112 268 2.4E-52 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS35185 59e8bb860efe96c3114d3d86f5c3f7e5 374 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 112 268 4.3E-46 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS18980 3d02ae294fc20b605378c094494b3376 399 SUPERFAMILY SSF52540 224 397 7.97E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18980 3d02ae294fc20b605378c094494b3376 399 Pfam PF02283 Cobinamide kinase / cobinamide phosphate guanyltransferase 224 396 4.9E-51 T 17-03-2017 IPR003203 Cobinamide kinase/cobinamide phosphate guanyltransferase GO:0000166|GO:0009236|GO:0043752|GO:0051188 KEGG: 00030+2.7.1.15|KEGG: 00860+2.7.7.62+2.7.1.156|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS18980 3d02ae294fc20b605378c094494b3376 399 Gene3D G3DSA:3.40.50.300 224 397 2.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18980 3d02ae294fc20b605378c094494b3376 399 Gene3D G3DSA:3.60.15.10 2 76 2.4E-11 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS18980 3d02ae294fc20b605378c094494b3376 399 SUPERFAMILY SSF56281 2 192 4.54E-6 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 Gene3D G3DSA:1.10.3810.10 96 273 1.5E-61 T 17-03-2017 SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 Gene3D G3DSA:3.40.710.10 441 625 1.4E-25 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 Gene3D G3DSA:3.40.710.10 274 432 3.0E-32 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 SUPERFAMILY SSF56601 305 615 5.63E-46 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 SUPERFAMILY SSF56601 260 276 5.63E-46 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 Pfam PF00905 Penicillin binding protein transpeptidase domain 380 433 6.3E-5 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 Pfam PF00905 Penicillin binding protein transpeptidase domain 464 574 3.1E-9 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 Pfam PF00912 Transglycosylase 95 272 4.5E-56 T 17-03-2017 IPR001264 Glycosyl transferase, family 51 SHXM_RS07015 607e2d161200dbbf644c9825b0131947 635 SUPERFAMILY SSF53955 87 287 6.19E-62 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS02870 43e02f74c6f4e76dc7a5ada10e445d56 347 ProSitePatterns PS00894 DeoR-type HTH domain signature. 10 44 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS02870 43e02f74c6f4e76dc7a5ada10e445d56 347 Pfam PF13280 WYL domain 145 329 5.3E-29 T 17-03-2017 IPR026881 WYL domain SHXM_RS02870 43e02f74c6f4e76dc7a5ada10e445d56 347 SUPERFAMILY SSF46785 7 66 5.69E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02870 43e02f74c6f4e76dc7a5ada10e445d56 347 Pfam PF08279 HTH domain 10 65 2.8E-16 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS02870 43e02f74c6f4e76dc7a5ada10e445d56 347 Gene3D G3DSA:1.10.10.10 3 68 1.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02870 43e02f74c6f4e76dc7a5ada10e445d56 347 PIRSF PIRSF016838 3 339 3.1E-20 T 17-03-2017 IPR028349 Protein PafC SHXM_RS08085 b1b5a6b229da9b5100bc27d7a27c8bef 285 SMART SM00563 95 207 7.8E-22 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS08085 b1b5a6b229da9b5100bc27d7a27c8bef 285 SUPERFAMILY SSF69593 89 209 1.83E-17 T 17-03-2017 SHXM_RS08085 b1b5a6b229da9b5100bc27d7a27c8bef 285 Pfam PF01553 Acyltransferase 79 203 1.2E-16 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS05425 2c2a70840a431685eb87e617587e400b 447 Pfam PF13416 Bacterial extracellular solute-binding protein 59 335 3.7E-25 T 17-03-2017 SHXM_RS05425 2c2a70840a431685eb87e617587e400b 447 Gene3D G3DSA:3.40.190.10 25 155 4.8E-12 T 17-03-2017 SHXM_RS05425 2c2a70840a431685eb87e617587e400b 447 Gene3D G3DSA:3.40.190.10 156 335 2.8E-32 T 17-03-2017 SHXM_RS05425 2c2a70840a431685eb87e617587e400b 447 SUPERFAMILY SSF53850 21 444 1.99E-47 T 17-03-2017 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 SMART SM00354 3 73 3.9E-20 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 SUPERFAMILY SSF47413 3 61 1.03E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 4.5E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 Gene3D G3DSA:3.40.50.2300 53 172 7.8E-32 T 17-03-2017 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 Gene3D G3DSA:3.40.50.2300 173 309 4.0E-39 T 17-03-2017 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 SUPERFAMILY SSF53822 61 313 4.71E-57 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 Pfam PF13377 Periplasmic binding protein-like domain 169 327 1.3E-34 T 17-03-2017 SHXM_RS39370 4dc2c539953080f84a6282ee1851a99f 332 Gene3D G3DSA:1.10.260.40 3 52 7.6E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15765 5c575667bc8ce572e3211ddcea0a618f 42 SUPERFAMILY SSF52374 1 40 7.74E-10 T 17-03-2017 SHXM_RS15765 5c575667bc8ce572e3211ddcea0a618f 42 Pfam PF00749 tRNA synthetases class I (E and Q), catalytic domain 2 40 8.6E-9 T 17-03-2017 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain GO:0005524|GO:0016876|GO:0043039 SHXM_RS15765 5c575667bc8ce572e3211ddcea0a618f 42 Gene3D G3DSA:3.40.50.620 1 40 9.6E-10 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS47925 d2969b2772538b814f9944e53964ff3b 329 Gene3D G3DSA:3.20.20.70 7 304 2.0E-50 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS47925 d2969b2772538b814f9944e53964ff3b 329 SUPERFAMILY SSF51412 7 317 5.95E-52 T 17-03-2017 SHXM_RS47925 d2969b2772538b814f9944e53964ff3b 329 Pfam PF03060 Nitronate monooxygenase 88 310 3.7E-37 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS47925 d2969b2772538b814f9944e53964ff3b 329 Pfam PF03060 Nitronate monooxygenase 10 86 2.2E-12 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SUPERFAMILY SSF81606 478 689 2.3E-9 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 491 690 2.3E-53 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Gene3D G3DSA:3.30.450.20 131 247 3.4E-13 T 17-03-2017 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SUPERFAMILY SSF55874 730 805 3.72E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SUPERFAMILY SSF55781 332 437 5.89E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Pfam PF08448 PAS fold 145 248 8.5E-16 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Gene3D G3DSA:3.30.450.40 259 440 1.3E-35 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Pfam PF00989 PAS fold 28 119 1.3E-7 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Gene3D G3DSA:3.30.450.20 27 118 3.4E-10 T 17-03-2017 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SMART SM00065 254 443 0.0068 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SUPERFAMILY SSF55785 131 247 1.41E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Pfam PF01590 GAF domain 271 433 4.2E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 Pfam PF13581 Histidine kinase-like ATPase domain 704 809 9.9E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 27 105 2.8E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 131 256 1.6E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SMART SM00091 7 78 1.4 T 17-03-2017 IPR000014 PAS domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SMART SM00091 134 200 0.0047 T 17-03-2017 IPR000014 PAS domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SUPERFAMILY SSF55785 28 119 4.19E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS06080 d90714652a9bbed588fb343659ff245c 819 SMART SM00331 464 690 1.8E-39 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1396 1516 2.0E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 4540 4659 1.6E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 369 498 5.1E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2859 2976 6.3E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00012 Phosphopantetheine attachment site. 956 971 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF51735 3629 3773 2.09E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF51735 2112 2334 2.03E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5 243 9.1E-80 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2487 2731 3.9E-85 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1021 1268 6.6E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4163 4412 2.0E-84 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 4325 4341 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:1.10.1200.10 4072 4143 1.7E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:1.10.1200.10 927 1002 4.2E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:1.10.1200.10 2387 2461 5.7E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:1.10.1200.10 5534 5608 3.6E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 530 658 2.01E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 727 824 2.01E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 4160 4424 8.2E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 4 255 5.2E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF53901 2485 2854 2.81E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF51735 5269 5501 3.61E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF47336 5530 5611 3.01E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF08659 KR domain 5271 5446 1.6E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF08659 KR domain 2114 2288 2.5E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF08659 KR domain 3791 3967 7.4E-48 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 1549 1674 8.37E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 1729 1825 8.37E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF47336 2387 2501 7.59E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.30.70.250 4809 4873 2.0E-9 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.30.70.250 657 724 8.3E-5 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF55048 4810 4874 4.19E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00698 Acyl transferase domain 533 852 1.2E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00698 Acyl transferase domain 1550 1860 9.9E-82 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00698 Acyl transferase domain 3003 3309 1.5E-77 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00698 Acyl transferase domain 4687 4958 1.3E-50 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 1728 1855 1.3E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 3181 3304 2.3E-69 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 1546 1669 1.3E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 2997 3122 2.3E-69 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF53901 1421 1441 9.26E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF53901 1019 1386 9.26E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 4685 4805 1.88E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 4867 4963 1.88E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF55048 3125 3176 1.96E-5 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 2489 2743 1.7E-84 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 1023 1280 4.3E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1181 1197 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF53901 393 413 6.22E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF53901 3 362 6.22E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF51735 3788 4021 1.33E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5563 5578 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2416 2431 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00550 Phosphopantetheine attachment site 5538 5604 5.6E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00550 Phosphopantetheine attachment site 932 997 1.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00550 Phosphopantetheine attachment site 2391 2457 1.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF00550 Phosphopantetheine attachment site 4075 4140 1.4E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 251 365 4.2E-38 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1276 1393 4.1E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 4420 4537 2.1E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2739 2856 2.4E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM01294 4077 4140 8.9E-5 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM01294 5537 5604 7.9E-6 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM01294 930 997 1.0E-4 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM01294 2390 2457 1.7E-5 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF47336 4068 4178 5.5E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.50.720 2114 2310 7.0E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 2744 2909 1.3E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 256 420 8.1E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 1281 1447 8.1E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.47.10 4425 4590 1.7E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF51735 1896 2102 3.23E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 4684 4805 3.4E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 4874 4963 3.4E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 725 835 2.4E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.366.10 525 652 2.4E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF51735 5075 5258 3.82E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00825 Beta-ketoacyl synthase 7 419 4.9E-191 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00825 Beta-ketoacyl synthase 2489 2909 3.7E-215 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00825 Beta-ketoacyl synthase 4165 4590 1.7E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00825 Beta-ketoacyl synthase 1023 1446 3.5E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1552 1841 3.2E-112 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3005 3290 1.3E-104 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 4687 4974 1.4E-113 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 534 833 5.3E-118 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.50.720 3790 3995 1.5E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Gene3D G3DSA:3.40.50.720 5272 5473 8.5E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF47336 926 1035 1.57E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF53901 4159 4534 3.49E-98 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00826 3352 3509 2.9E-72 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00823 Phosphopantetheine attachment site 4072 4144 9.0E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00823 Phosphopantetheine attachment site 5536 5608 1.6E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00823 Phosphopantetheine attachment site 929 1001 1.4E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00823 Phosphopantetheine attachment site 2389 2461 1.3E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4099 4114 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3791 3968 3.7E-39 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2114 2290 1.1E-48 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5271 5447 7.6E-48 T 17-03-2017 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF55048 657 726 1.7E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 3002 3127 4.19E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF52151 3182 3274 4.19E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2644 2660 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 SUPERFAMILY SSF55048 1672 1724 2.75E-6 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05390 36f57b08d2ca0802e1b7a60c85410425 5684 Pfam PF14765 Polyketide synthase dehydratase 3352 3621 2.7E-54 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 Gene3D G3DSA:2.60.120.260 472 545 4.5E-9 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 Gene3D G3DSA:3.20.20.70 84 362 6.6E-93 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 SMART SM00458 556 683 2.1E-26 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 Pfam PF16499 Alpha galactosidase A 85 413 1.9E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 SUPERFAMILY SSF49785 471 542 1.36E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 PRINTS PR00740 Glycosyl hydrolase family 27 signature 324 345 2.3E-22 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 PRINTS PR00740 Glycosyl hydrolase family 27 signature 303 322 2.3E-22 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 PRINTS PR00740 Glycosyl hydrolase family 27 signature 78 97 2.3E-22 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 PRINTS PR00740 Glycosyl hydrolase family 27 signature 114 129 2.3E-22 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 PRINTS PR00740 Glycosyl hydrolase family 27 signature 155 176 2.3E-22 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 SUPERFAMILY SSF51011 363 458 1.73E-12 T 17-03-2017 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 Pfam PF00652 Ricin-type beta-trefoil lectin domain 559 680 2.1E-25 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 Gene3D G3DSA:2.60.40.1180 363 460 7.5E-26 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 SUPERFAMILY SSF50370 558 682 2.55E-35 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 Gene3D G3DSA:2.80.10.50 559 682 2.3E-35 T 17-03-2017 SHXM_RS21795 0a9b17b10fa85ecc788217d1f1da4251 683 SUPERFAMILY SSF51445 83 369 4.81E-71 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:1.10.1200.10 1706 1779 4.5E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF00975 Thioesterase domain 1860 2073 2.4E-17 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 411 538 1.8E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF53901 29 406 1.48E-108 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF53474 1737 1775 4.71E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF53474 1836 2075 4.71E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:3.40.47.10 296 465 3.4E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF101173 2 33 1.57E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM00826 933 1096 5.4E-87 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM00824 Thioesterase 1861 2074 4.9E-110 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF51735 1420 1631 5.32E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF55048 697 749 3.27E-7 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF08990 Erythronolide synthase docking 3 26 2.7E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1734 1749 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:3.40.50.720 1421 1631 1.9E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1421 1601 5.7E-61 T 17-03-2017 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 196 212 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM00823 Phosphopantetheine attachment site 1707 1779 1.9E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 570 866 2.1E-109 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:3.40.366.10 757 870 1.4E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:3.40.366.10 564 692 1.4E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF51735 1220 1407 1.73E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF08659 KR domain 1421 1599 6.6E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 33 283 1.3E-95 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:3.40.50.1820 1805 2079 1.1E-84 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM00825 Beta-ketoacyl synthase 35 463 1.1E-234 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF52151 566 698 9.42E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SUPERFAMILY SSF52151 759 856 9.42E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Gene3D G3DSA:3.40.47.10 29 295 1.1E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF14765 Polyketide synthase dehydratase 933 1212 3.3E-59 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 SMART SM01294 1708 1775 1.4E-4 T 17-03-2017 SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF00550 Phosphopantetheine attachment site 1709 1775 1.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF00698 Acyl transferase domain 569 875 1.8E-52 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07220 5bfc199bc9fd27bb7a0b0cb41a709317 2082 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 291 408 4.0E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Gene3D G3DSA:1.10.150.20 549 630 7.6E-28 T 17-03-2017 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Pfam PF00533 BRCA1 C Terminus (BRCT) domain 638 706 3.7E-12 T 17-03-2017 IPR001357 BRCT domain SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SUPERFAMILY SSF56091 11 327 2.23E-112 T 17-03-2017 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Gene3D G3DSA:3.40.50.10190 638 715 1.9E-22 T 17-03-2017 IPR001357 BRCT domain SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SMART SM00532 12 458 1.9E-255 T 17-03-2017 IPR013840 NAD-dependent DNA ligase, N-terminal GO:0003911 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Pfam PF03119 NAD-dependent DNA ligase C4 zinc finger domain 417 444 1.6E-7 T 17-03-2017 IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type GO:0003911|GO:0006260|GO:0006281 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Pfam PF03120 NAD-dependent DNA ligase OB-fold domain 331 407 5.7E-28 T 17-03-2017 IPR004150 NAD-dependent DNA ligase, OB-fold GO:0003911|GO:0006260|GO:0006281 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Gene3D G3DSA:2.40.50.140 329 399 3.6E-26 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Gene3D G3DSA:1.10.287.610 7 74 2.6E-28 T 17-03-2017 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SUPERFAMILY SSF50249 327 409 2.74E-24 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Pfam PF12826 Helix-hairpin-helix motif 555 618 4.1E-22 T 17-03-2017 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Pfam PF01653 NAD-dependent DNA ligase adenylation domain 12 327 5.1E-122 T 17-03-2017 IPR013839 NAD-dependent DNA ligase, adenylation GO:0003911 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 ProSitePatterns PS01055 NAD-dependent DNA ligase signature 1. 123 152 - T 17-03-2017 IPR018239 NAD-dependent DNA ligase, active site SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Gene3D G3DSA:1.10.150.20 445 546 2.4E-9 T 17-03-2017 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 PIRSF PIRSF001604 4 716 3.9E-238 T 17-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SUPERFAMILY SSF52113 637 714 1.25E-17 T 17-03-2017 IPR001357 BRCT domain SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SUPERFAMILY SSF47781 412 505 1.26E-44 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SUPERFAMILY SSF47781 536 628 1.26E-44 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 ProSitePatterns PS01056 NAD-dependent DNA ligase signature 2. 340 355 - T 17-03-2017 IPR033136 NAD-dependent DNA ligase, conserved site SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Gene3D G3DSA:3.30.470.30 127 259 2.3E-50 T 17-03-2017 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 TIGRFAM TIGR00575 dnlj: DNA ligase, NAD-dependent 20 500 8.7E-176 T 17-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 SMART SM00292 638 715 6.7E-11 T 17-03-2017 IPR001357 BRCT domain SHXM_RS36080 4bc0471b29178013a9abe033d9892d73 732 Hamap MF_01588 DNA ligase [ligA]. 11 712 51.041 T 17-03-2017 IPR001679 NAD-dependent DNA ligase GO:0003911|GO:0006260|GO:0006281 SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Pfam PF07732 Multicopper oxidase 71 180 8.0E-27 T 17-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Gene3D G3DSA:2.60.40.420 51 182 2.0E-31 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 SUPERFAMILY SSF49503 54 197 4.5E-36 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Gene3D G3DSA:2.60.40.420 411 537 3.4E-41 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 SUPERFAMILY SSF49503 182 230 2.66E-29 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 SUPERFAMILY SSF49503 283 396 2.66E-29 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 ProSitePatterns PS00080 Multicopper oxidases signature 2. 520 531 - T 17-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Gene3D G3DSA:2.60.40.420 184 224 4.7E-45 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Gene3D G3DSA:2.60.40.420 262 399 4.7E-45 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 ProSitePatterns PS00079 Multicopper oxidases signature 1. 515 535 - T 17-03-2017 IPR033138 Multicopper oxidases, conserved site SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 SUPERFAMILY SSF49503 420 536 1.21E-32 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Pfam PF00394 Multicopper oxidase 189 384 8.2E-21 T 17-03-2017 IPR001117 Multicopper oxidase, type 1 GO:0016491|GO:0055114 SHXM_RS48040 6cdb8e2f146f537f6239f1292ccb98f0 539 Pfam PF07731 Multicopper oxidase 430 535 4.3E-25 T 17-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 SHXM_RS45600 c60c8bc70c2cf4a53a97da0dd3d4b399 367 SUPERFAMILY SSF46785 4 64 1.52E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45600 c60c8bc70c2cf4a53a97da0dd3d4b399 367 Pfam PF13280 WYL domain 144 361 5.7E-35 T 17-03-2017 IPR026881 WYL domain SHXM_RS45600 c60c8bc70c2cf4a53a97da0dd3d4b399 367 Pfam PF08279 HTH domain 7 62 1.3E-10 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS45600 c60c8bc70c2cf4a53a97da0dd3d4b399 367 Gene3D G3DSA:1.10.10.10 6 66 7.8E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 TIGRFAM TIGR00615 recR: recombination protein RecR 2 195 1.7E-84 T 17-03-2017 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 Gene3D G3DSA:3.40.50.140 36 71 1.3E-6 T 17-03-2017 IPR006171 Toprim domain SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 Gene3D G3DSA:3.40.50.140 110 169 1.3E-6 T 17-03-2017 IPR006171 Toprim domain SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 ProSitePatterns PS01300 RecR protein signature. 56 77 - T 17-03-2017 IPR015967 Recombination protein RecR, conserved site GO:0006281|GO:0006310 SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 Pfam PF00633 Helix-hairpin-helix motif 2 27 4.7E-6 T 17-03-2017 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 SMART SM00493 79 164 7.1E-16 T 17-03-2017 IPR006171 Toprim domain SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 Pfam PF13662 Toprim domain 80 170 1.1E-25 T 17-03-2017 IPR006171 Toprim domain SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 Pfam PF02132 RecR protein 38 77 1.3E-16 T 17-03-2017 IPR023628 Recombination protein RecR, C4-type zinc finger SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 SUPERFAMILY SSF111304 3 197 3.92E-75 T 17-03-2017 IPR023627 Recombination protein RecR SHXM_RS27145 fec871da69075a824c77116c64ed67fe 199 Hamap MF_00017 Recombination protein RecR [recR]. 1 197 108.562 T 17-03-2017 IPR000093 DNA recombination protein RecR GO:0003677|GO:0006281|GO:0006310 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 SUPERFAMILY SSF52172 3 137 2.99E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 SUPERFAMILY SSF46894 148 218 3.4E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 Gene3D G3DSA:1.10.10.10 126 220 4.8E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 Gene3D G3DSA:3.40.50.2300 3 125 6.9E-39 T 17-03-2017 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 SMART SM00421 155 212 2.1E-28 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 212 1.7E-21 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 Pfam PF00072 Response regulator receiver domain 5 119 3.5E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 3.0E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 3.0E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 3.0E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS15960 bc19bcf84e156e1078d16cb43a815974 223 SMART SM00448 3 118 6.8E-36 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 222 310 6.7E-26 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 2 311 57.179 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 SUPERFAMILY SSF53901 6 310 9.51E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 Gene3D G3DSA:3.40.47.10 2 160 4.8E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 Gene3D G3DSA:3.40.47.10 161 311 6.2E-39 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 107 180 3.8E-25 T 17-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS34680 1d302f963c37c9bab11dd902ed2a7009 312 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 5 310 2.5E-88 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS15025 59d664bea8565fc1fccaa8774f1c710d 68 SUPERFAMILY SSF51679 15 68 6.56E-11 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS15025 59d664bea8565fc1fccaa8774f1c710d 68 Pfam PF00296 Luciferase-like monooxygenase 15 68 1.6E-9 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS15025 59d664bea8565fc1fccaa8774f1c710d 68 Gene3D G3DSA:3.20.20.30 7 68 4.9E-13 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 SUPERFAMILY SSF51735 152 340 8.41E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 Pfam PF13823 Alcohol dehydrogenase GroES-associated 2 23 1.9E-6 T 17-03-2017 IPR027399 Alcohol dehydrogenase GroES-associated SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 Gene3D G3DSA:3.90.180.10 2 87 3.2E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 Gene3D G3DSA:3.90.180.10 124 174 3.2E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 SMART SM00829 15 375 0.0062 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 SUPERFAMILY SSF50129 2 184 1.83E-60 T 17-03-2017 IPR011032 GroES-like SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 137 3.3E-27 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 Gene3D G3DSA:3.40.50.720 175 334 5.4E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07960 526bcd66450ea0a33f5fd288a77462fb 381 Pfam PF00107 Zinc-binding dehydrogenase 185 254 1.1E-10 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS05030 2d8e16496d170be2a7664f219e3d188d 473 Gene3D G3DSA:3.40.50.850 90 248 2.1E-5 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 SUPERFAMILY SSF103473 43 466 2.09E-73 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 Gene3D G3DSA:1.20.1250.20 276 463 5.9E-22 T 17-03-2017 SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 Gene3D G3DSA:1.20.1250.20 46 254 2.9E-26 T 17-03-2017 SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 Pfam PF00083 Sugar (and other) transporter 267 467 7.5E-16 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 Pfam PF00083 Sugar (and other) transporter 51 254 4.4E-30 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 ProSitePatterns PS00216 Sugar transport proteins signature 1. 333 350 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS14360 25bcc17259014f617ee44a3cf6d13507 487 ProSitePatterns PS00217 Sugar transport proteins signature 2. 158 183 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 Gene3D G3DSA:1.10.10.10 18 142 1.2E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 SUPERFAMILY SSF46785 20 143 2.44E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 PRINTS PR00598 Bacterial regulatory protein MarR family signature 75 90 2.6E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 PRINTS PR00598 Bacterial regulatory protein MarR family signature 94 110 2.6E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 PRINTS PR00598 Bacterial regulatory protein MarR family signature 124 144 2.6E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 SMART SM00347 34 134 1.1E-20 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS46210 6affc00cd06f048ec926d8fd9535221f 167 Pfam PF01047 MarR family 47 99 1.6E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS40430 1adecfe15ec06433b011fe3996521d60 310 Gene3D G3DSA:2.120.10.30 73 299 9.4E-33 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS40430 1adecfe15ec06433b011fe3996521d60 310 Hamap MF_01282 Virginiamycin B lyase [vgb]. 8 293 41.839 T 17-03-2017 IPR011217 Streptogramin lyase GO:0000287|GO:0016835|GO:0017001|GO:0046677 SHXM_RS40430 1adecfe15ec06433b011fe3996521d60 310 PIRSF PIRSF026412 2 298 1.4E-94 T 17-03-2017 IPR011217 Streptogramin lyase GO:0000287|GO:0016835|GO:0017001|GO:0046677 SHXM_RS40430 1adecfe15ec06433b011fe3996521d60 310 Gene3D G3DSA:2.120.10.30 10 72 4.4E-6 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS40430 1adecfe15ec06433b011fe3996521d60 310 SUPERFAMILY SSF63829 10 250 1.63E-31 T 17-03-2017 SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 Gene3D G3DSA:1.10.357.10 6 188 2.8E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 SUPERFAMILY SSF48498 85 188 2.87E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 Pfam PF13977 Bacterial transcriptional repressor 93 185 2.9E-6 T 17-03-2017 SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 SUPERFAMILY SSF46689 4 68 4.93E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 15 28 6.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 59 6.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20345 843bc86f0b8b35212eec3c30e0df520e 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 61 4.0E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36095 b5569ad1d3b96c595f20f91c837da941 497 Gene3D G3DSA:3.90.1300.10 2 486 2.3E-176 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS36095 b5569ad1d3b96c595f20f91c837da941 497 TIGRFAM TIGR00132 gatA: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit 15 482 9.3E-189 T 17-03-2017 IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit GO:0006412 KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS36095 b5569ad1d3b96c595f20f91c837da941 497 Pfam PF01425 Amidase 25 471 4.5E-158 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS36095 b5569ad1d3b96c595f20f91c837da941 497 Hamap MF_00120 Glutamyl-tRNA(Gln) amidotransferase subunit A [gatA]. 12 483 91.623 T 17-03-2017 IPR004412 Glutamyl-tRNA(Gln) amidotransferase A subunit GO:0006412 KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS36095 b5569ad1d3b96c595f20f91c837da941 497 SUPERFAMILY SSF75304 2 482 6.15E-162 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS36095 b5569ad1d3b96c595f20f91c837da941 497 ProSitePatterns PS00571 Amidases signature. 153 184 - T 17-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 SHXM_RS24750 e0e0085724df9c43c4286855b1b97ed4 333 Gene3D G3DSA:3.20.20.70 63 325 2.6E-91 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS24750 e0e0085724df9c43c4286855b1b97ed4 333 Pfam PF01791 DeoC/LacD family aldolase 65 311 1.1E-24 T 17-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 SHXM_RS24750 e0e0085724df9c43c4286855b1b97ed4 333 SUPERFAMILY SSF51569 70 313 5.86E-72 T 17-03-2017 SHXM_RS24750 e0e0085724df9c43c4286855b1b97ed4 333 TIGRFAM TIGR00126 deoC: deoxyribose-phosphate aldolase 72 295 1.5E-51 T 17-03-2017 IPR011343 Deoxyribose-phosphate aldolase GO:0004139|GO:0005737|GO:0009264 KEGG: 00030+4.1.2.4|MetaCyc: PWY-7180|Reactome: R-HSA-71336 SHXM_RS24750 e0e0085724df9c43c4286855b1b97ed4 333 SMART SM01133 69 314 7.1E-75 T 17-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 SUPERFAMILY SSF50129 194 332 9.43E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 216 271 2.9E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 SUPERFAMILY SSF51735 295 423 1.42E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 Gene3D G3DSA:3.40.50.720 286 467 1.7E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 323 344 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 SUPERFAMILY SSF51735 3 174 2.36E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 Pfam PF13602 Zinc-binding dehydrogenase 369 493 1.5E-14 T 17-03-2017 SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 SMART SM00829 196 493 5.4E-165 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS05305 878fedeb8855d494d6e0e8008188b094 493 Gene3D G3DSA:3.90.180.10 204 275 4.7E-10 T 17-03-2017 IPR011032 GroES-like SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1682 1693 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF52777 1251 1517 2.56E-61 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 ProSitePatterns PS00455 Putative AMP-binding domain signature. 613 624 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF52777 6 204 3.11E-43 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SMART SM00823 Phosphopantetheine attachment site 978 1047 1.8E-5 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SMART SM00823 Phosphopantetheine attachment site 2043 2111 2.2E-5 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF56801 423 991 7.98E-165 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:3.30.300.30 1930 2048 1.6E-40 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:3.30.300.30 864 980 2.9E-43 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF52777 2121 2325 1.89E-29 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:1.10.1200.10 2049 2107 2.2E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:1.10.1200.10 981 1045 1.8E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00550 Phosphopantetheine attachment site 2046 2106 3.9E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00550 Phosphopantetheine attachment site 981 1040 1.1E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF47336 2038 2106 1.96E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SMART SM01294 2044 2107 0.0012 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF47336 971 1043 6.28E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2067 2082 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:2.30.38.10 781 859 9.0E-25 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:2.30.38.10 1844 1925 4.1E-25 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 485 893 3.8E-138 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1553 1959 3.3E-129 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF52777 1064 1237 1.45E-47 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF52777 2318 2585 1.06E-29 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 2451 2609 4.0E-39 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:3.40.50.980 1527 1690 3.8E-49 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:3.40.50.980 457 621 2.7E-49 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF52777 189 452 3.89E-59 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:3.40.50.980 1691 1836 1.5E-27 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Gene3D G3DSA:3.40.50.980 622 780 5.4E-47 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00501 AMP-binding enzyme 464 869 1.4E-99 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00501 AMP-binding enzyme 1533 1935 3.5E-89 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00668 Condensation domain 2143 2436 1.9E-30 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00668 Condensation domain 1061 1361 9.8E-61 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF00668 Condensation domain 8 303 5.4E-68 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1002 1017 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF13745 HxxPF-repeated domain 1383 1479 7.1E-33 T 17-03-2017 SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF13193 AMP-binding enzyme C-terminal domain 877 953 2.2E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 Pfam PF13193 AMP-binding enzyme C-terminal domain 1943 2018 5.7E-14 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37805 3254d4f919b94537fb1272f2b27c429a 2630 SUPERFAMILY SSF56801 1491 2056 5.49E-151 T 17-03-2017 SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 258 4.2E-45 T 17-03-2017 SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 Gene3D G3DSA:3.40.50.720 4 259 8.3E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 SUPERFAMILY SSF51735 3 259 2.83E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 1.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 1.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 1.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 1.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04260 4b6e5ff9d243b5297dbf53b9ae8bdb60 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 222 242 1.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6168 6183 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF47336 5091 5199 4.84E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF47336 2531 2603 3.14E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 45 218 1.89E-53 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 527 914 1.3E-117 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4634 5014 7.7E-118 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3111 3502 8.4E-110 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2036 2450 1.1E-135 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 5671 6051 2.8E-128 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13193 AMP-binding enzyme C-terminal domain 3486 3567 3.4E-14 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13193 AMP-binding enzyme C-terminal domain 2434 2510 3.2E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13193 AMP-binding enzyme C-terminal domain 6035 6116 4.1E-10 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13193 AMP-binding enzyme C-terminal domain 898 974 6.2E-15 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13193 AMP-binding enzyme C-terminal domain 4998 5073 2.3E-12 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF56801 3046 3607 7.98E-142 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 3863 4117 2.78E-48 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 1272 1526 6.89E-43 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 4761 4901 1.0E-31 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 5797 5939 7.9E-35 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 1736 1978 1.08E-57 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13745 HxxPF-repeated domain 2944 3034 2.3E-33 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13745 HxxPF-repeated domain 5506 5597 5.8E-32 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF13745 HxxPF-repeated domain 358 451 1.4E-22 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 5189 5366 3.22E-51 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF47336 995 1066 8.64E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 5372 5637 9.89E-64 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.30.300.30 6022 6147 9.2E-40 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.30.300.30 3473 3597 3.4E-41 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.30.300.30 4985 5102 2.3E-40 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.30.300.30 885 1006 1.2E-42 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.30.300.30 2421 2541 4.9E-41 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 5644 5796 2.4E-47 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 498 642 5.5E-46 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 4608 4760 6.6E-41 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 2008 2169 7.2E-47 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 3080 3228 6.4E-43 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00455 Putative AMP-binding domain signature. 3218 3229 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF56801 1974 2551 5.49E-161 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 3229 3380 3.9E-30 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 2170 2325 8.6E-46 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:3.40.50.980 643 796 1.5E-31 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 4149 4449 1.2E-60 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 5185 5484 1.8E-70 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 3674 3977 3.7E-51 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 1083 1383 5.6E-49 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 6222 6521 2.4E-58 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 1552 1852 2.7E-63 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 2622 2922 1.5E-70 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00668 Condensation domain 42 336 6.4E-75 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 3672 3851 4.0E-41 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF56801 5609 6157 2.49E-159 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF47336 6137 6206 5.5E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00501 AMP-binding enzyme 2015 2426 3.6E-96 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00501 AMP-binding enzyme 5650 6027 6.6E-90 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00501 AMP-binding enzyme 4613 4990 2.6E-83 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00501 AMP-binding enzyme 504 890 2.2E-86 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00501 AMP-binding enzyme 3087 3478 1.0E-82 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 2626 2803 2.33E-49 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:2.30.38.10 801 879 6.4E-24 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:2.30.38.10 5940 6017 1.5E-28 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:2.30.38.10 4902 4980 3.6E-26 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:2.30.38.10 3389 3468 4.7E-24 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:2.30.38.10 2337 2416 2.6E-25 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00550 Phosphopantetheine attachment site 1004 1066 1.1E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00550 Phosphopantetheine attachment site 2540 2603 1.8E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00550 Phosphopantetheine attachment site 3597 3654 5.6E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00550 Phosphopantetheine attachment site 5101 5164 2.0E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Pfam PF00550 Phosphopantetheine attachment site 6146 6205 8.3E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1391 1544 4.7E-33 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 3985 4140 4.5E-38 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00455 Putative AMP-binding domain signature. 4737 4748 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF56801 4576 5112 7.98E-150 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2562 2577 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 225 475 1.67E-55 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SMART SM00823 Phosphopantetheine attachment site 2538 2607 4.4E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SMART SM00823 Phosphopantetheine attachment site 6144 6212 6.1E-6 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SMART SM00823 Phosphopantetheine attachment site 1002 1070 7.2E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SMART SM00823 Phosphopantetheine attachment site 5099 5168 1.0E-11 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SMART SM00823 Phosphopantetheine attachment site 3594 3662 3.9E-4 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 2812 3075 2.89E-65 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5123 5138 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 4334 4577 1.45E-55 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 1081 1259 6.23E-39 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:1.10.1200.10 5103 5167 3.3E-27 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:1.10.1200.10 6148 6213 1.6E-28 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:1.10.1200.10 3598 3661 1.5E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:1.10.1200.10 2542 2604 8.3E-27 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 Gene3D G3DSA:1.10.1200.10 1007 1070 6.9E-28 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 4147 4349 7.11E-40 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3618 3633 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1026 1041 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00455 Putative AMP-binding domain signature. 634 645 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF56801 463 1014 1.44E-147 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF47336 3586 3654 1.44E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 6218 6422 9.45E-42 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 1550 1750 1.56E-41 T 17-03-2017 SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 ProSitePatterns PS00455 Putative AMP-binding domain signature. 5775 5786 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04080 b72fb7ea104386ff41520ff881d4a952 6668 SUPERFAMILY SSF52777 6411 6664 2.67E-39 T 17-03-2017 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 TIGRFAM TIGR03594 GTPase_EngA: ribosome-associated GTPase EngA 50 478 1.2E-156 T 17-03-2017 IPR016484 GTP-binding protein EngA GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Gene3D G3DSA:3.30.300.20 406 480 9.8E-27 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 276 291 7.1E-6 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 227 247 7.1E-6 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 SMART SM00382 223 366 0.0014 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 SMART SM00382 48 184 0.13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Gene3D G3DSA:3.40.50.300 50 215 7.0E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Gene3D G3DSA:3.40.50.300 224 405 9.9E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Pfam PF01926 50S ribosome-binding GTPase 52 166 5.9E-25 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Pfam PF01926 50S ribosome-binding GTPase 226 344 1.4E-21 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 225 391 2.8E-21 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 52 171 3.2E-23 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 SUPERFAMILY SSF52540 184 481 1.55E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Pfam PF14714 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal 400 478 2.6E-24 T 17-03-2017 IPR032859 GTPase Der, C-terminal KH-domain-like SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 PIRSF PIRSF006485 48 486 3.6E-157 T 17-03-2017 IPR016484 GTP-binding protein EngA GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 Hamap MF_00195 GTPase Der [der]. 49 481 35.429 T 17-03-2017 IPR016484 GTP-binding protein EngA GO:0005525 SHXM_RS17035 e43dbab132a7ca672322380832ef090e 487 SUPERFAMILY SSF52540 51 214 3.52E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24940 de3011ed7855dd3d942821f03224b93c 399 SUPERFAMILY SSF56784 246 394 3.39E-30 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS24940 de3011ed7855dd3d942821f03224b93c 399 Gene3D G3DSA:3.40.50.1000 240 394 4.6E-31 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS24940 de3011ed7855dd3d942821f03224b93c 399 Gene3D G3DSA:3.90.550.10 8 229 9.3E-71 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24940 de3011ed7855dd3d942821f03224b93c 399 SUPERFAMILY SSF53448 8 229 8.73E-48 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24940 de3011ed7855dd3d942821f03224b93c 399 Pfam PF02348 Cytidylyltransferase 10 186 4.5E-22 T 17-03-2017 IPR003329 Acylneuraminate cytidylyltransferase KEGG: 00540+2.7.7.38|MetaCyc: PWY-1269|Reactome: R-HSA-4085001 SHXM_RS24940 de3011ed7855dd3d942821f03224b93c 399 Pfam PF08282 haloacid dehalogenase-like hydrolase 321 385 3.7E-8 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27210 97e327bd36d437e972683d0e542de0f2 388 SUPERFAMILY SSF55874 270 385 1.02E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27210 97e327bd36d437e972683d0e542de0f2 388 Gene3D G3DSA:3.30.565.10 300 386 4.5E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27210 97e327bd36d437e972683d0e542de0f2 388 SMART SM00387 298 388 0.0029 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27210 97e327bd36d437e972683d0e542de0f2 388 Pfam PF13796 Putative sensor 15 147 2.2E-11 T 17-03-2017 IPR025828 Putative sensor domain SHXM_RS27210 97e327bd36d437e972683d0e542de0f2 388 Pfam PF07730 Histidine kinase 195 261 3.3E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1105 1506 3.5E-133 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 35 446 2.8E-130 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1234 1245 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:1.10.1200.10 1595 1658 9.2E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:1.10.1200.10 534 597 9.9E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:3.30.300.30 1477 1594 2.8E-42 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:3.30.300.30 418 533 6.6E-39 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF00501 AMP-binding enzyme 14 422 1.9E-95 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF00501 AMP-binding enzyme 1085 1482 1.2E-95 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF00550 Phosphopantetheine attachment site 533 595 1.3E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF00550 Phosphopantetheine attachment site 1593 1653 2.1E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF52777 803 1069 1.89E-61 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF52777 616 789 1.56E-48 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF47336 1584 1653 2.62E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF52777 1866 2137 2.33E-28 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF56801 6 542 5.1E-158 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF52777 1674 1851 1.45E-27 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF13193 AMP-binding enzyme C-terminal domain 1490 1566 2.1E-14 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF13193 AMP-binding enzyme C-terminal domain 430 505 9.9E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:3.40.50.980 1079 1255 8.9E-50 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:3.40.50.980 8 165 1.6E-49 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF13745 HxxPF-repeated domain 935 1031 5.6E-33 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1997 2156 2.0E-37 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:2.30.38.10 333 412 6.1E-24 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:2.30.38.10 1395 1472 4.2E-26 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1615 1630 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF47336 523 595 3.93E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF00668 Condensation domain 1693 1985 1.2E-31 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Pfam PF00668 Condensation domain 613 913 3.0E-61 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 ProSitePatterns PS00012 Phosphopantetheine attachment site. 554 569 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 ProSitePatterns PS00455 Putative AMP-binding domain signature. 157 168 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SUPERFAMILY SSF56801 1043 1604 7.59E-158 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:3.40.50.980 1256 1394 8.9E-35 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 Gene3D G3DSA:3.40.50.980 166 323 1.1E-44 T 17-03-2017 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SMART SM00823 Phosphopantetheine attachment site 1591 1659 1.8E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS37800 a7f42ee29196930efcdbb91c8463e4ae 2164 SMART SM00823 Phosphopantetheine attachment site 530 599 1.4E-5 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 SMART SM00345 13 71 7.0E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 Gene3D G3DSA:1.20.120.530 74 191 6.2E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 Pfam PF07729 FCD domain 81 200 3.1E-17 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 Gene3D G3DSA:1.10.10.10 7 72 3.8E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 Pfam PF00392 Bacterial regulatory proteins, gntR family 10 71 4.2E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 SMART SM00895 81 202 6.3E-12 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 SUPERFAMILY SSF48008 77 191 3.92E-21 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS19020 db65c5bbf6c85375f625eb62a95a6c94 207 SUPERFAMILY SSF46785 8 97 2.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21495 afffc193544a6da545e927116a10cda4 492 TIGRFAM TIGR00360 ComEC_N-term: ComEC/Rec2-related protein 196 372 6.8E-12 T 17-03-2017 IPR004477 ComEC/Rec2-related protein SHXM_RS21495 afffc193544a6da545e927116a10cda4 492 Pfam PF03772 Competence protein 174 449 8.1E-41 T 17-03-2017 IPR004477 ComEC/Rec2-related protein SHXM_RS29480 32affe1255621af2fa5ba0f4917bee38 180 PRINTS PR00502 NUDIX hydrolase family signature 69 83 3.8E-8 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS29480 32affe1255621af2fa5ba0f4917bee38 180 PRINTS PR00502 NUDIX hydrolase family signature 83 98 3.8E-8 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS29480 32affe1255621af2fa5ba0f4917bee38 180 Gene3D G3DSA:3.90.79.10 2 172 4.0E-39 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS29480 32affe1255621af2fa5ba0f4917bee38 180 SUPERFAMILY SSF55811 3 171 1.07E-37 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS29480 32affe1255621af2fa5ba0f4917bee38 180 ProSitePatterns PS00893 Nudix box signature. 74 95 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS29480 32affe1255621af2fa5ba0f4917bee38 180 Pfam PF00293 NUDIX domain 39 151 6.1E-21 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 Pfam PF00037 4Fe-4S binding domain 34 56 6.7E-7 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 PRINTS PR00354 7Fe ferredoxin signature 35 52 1.1E-13 T 17-03-2017 IPR000813 7Fe ferredoxin GO:0009055 SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 PRINTS PR00354 7Fe ferredoxin signature 19 29 1.1E-13 T 17-03-2017 IPR000813 7Fe ferredoxin GO:0009055 SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 PRINTS PR00354 7Fe ferredoxin signature 9 19 1.1E-13 T 17-03-2017 IPR000813 7Fe ferredoxin GO:0009055 SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 40 51 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 SUPERFAMILY SSF54862 2 75 1.78E-17 T 17-03-2017 SHXM_RS45765 d7dc2e701685013f2b48c7349cb33343 106 Gene3D G3DSA:3.30.70.20 4 66 1.9E-16 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 4 574 6.4E-279 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 SUPERFAMILY SSF53067 3 159 6.29E-57 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:1.20.1270.10 504 574 9.3E-28 T 17-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 SUPERFAMILY SSF53067 161 353 1.17E-65 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Pfam PF00012 Hsp70 protein 4 574 2.5E-246 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:3.30.420.40 169 199 4.8E-34 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:3.30.420.40 289 331 4.8E-34 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:3.30.420.40 4 38 2.5E-55 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:3.30.420.40 101 168 2.5E-55 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:3.30.30.30 39 100 1.4E-16 T 17-03-2017 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 ProSitePatterns PS01036 Heat shock hsp70 proteins family signature 3. 307 321 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 54 62 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 336 356 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 304 320 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 440 456 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 114 134 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 31 43 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 172 182 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 359 378 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 PRINTS PR00301 70kDa heat shock protein signature 3 16 1.7E-74 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 SUPERFAMILY SSF100934 478 576 7.06E-16 T 17-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:2.60.34.10 361 503 1.3E-73 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 7 14 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 SUPERFAMILY SSF100920 355 511 9.94E-60 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2. 166 179 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 1 612 36.182 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS29085 46634fca0a64bc7cf93a0fb8b6bb606b 623 Gene3D G3DSA:3.90.640.10 200 285 2.7E-31 T 17-03-2017 SHXM_RS27060 b503d95ad831c769b8ea32fac25a3df1 134 SUPERFAMILY SSF101386 37 95 4.67E-11 T 17-03-2017 SHXM_RS27060 b503d95ad831c769b8ea32fac25a3df1 134 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase 9 91 2.6E-25 T 17-03-2017 IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like KEGG: 00340+3.6.1.31 SHXM_RS27060 b503d95ad831c769b8ea32fac25a3df1 134 Gene3D G3DSA:1.10.3420.10 2 130 2.0E-43 T 17-03-2017 IPR023292 NTP pyrophosphohydrolase-like domain SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 Pfam PF00356 Bacterial regulatory proteins, lacI family 27 72 1.4E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 Pfam PF13377 Periplasmic binding protein-like domain 195 345 9.0E-16 T 17-03-2017 SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 Gene3D G3DSA:3.40.50.2300 80 201 6.3E-21 T 17-03-2017 SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 SUPERFAMILY SSF53822 106 343 1.1E-25 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 Gene3D G3DSA:3.40.50.2300 202 332 9.3E-19 T 17-03-2017 SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 Gene3D G3DSA:1.10.260.40 26 79 5.8E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 SMART SM00354 22 97 1.6E-11 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS46850 d3dc6aee51f0941dfaf99ca9fe977bb4 363 SUPERFAMILY SSF47413 22 84 1.44E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26130 a3cb264e54e6fdd91b4c508ffe78746d 456 Gene3D G3DSA:1.20.1250.20 217 403 1.4E-20 T 17-03-2017 SHXM_RS26130 a3cb264e54e6fdd91b4c508ffe78746d 456 Gene3D G3DSA:1.20.1250.20 19 199 3.6E-30 T 17-03-2017 SHXM_RS26130 a3cb264e54e6fdd91b4c508ffe78746d 456 Pfam PF07690 Major Facilitator Superfamily 25 368 1.5E-42 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS26130 a3cb264e54e6fdd91b4c508ffe78746d 456 SUPERFAMILY SSF103473 18 408 1.96E-59 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 SUPERFAMILY SSF55447 225 326 4.97E-27 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 219 2.2E-48 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 SMART SM01092 226 324 6.3E-30 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 SUPERFAMILY SSF56176 1 219 2.56E-56 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 227 323 1.9E-17 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 Gene3D G3DSA:3.30.390.50 225 328 3.0E-35 T 17-03-2017 SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 Gene3D G3DSA:3.30.43.10 1 51 3.4E-19 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 Gene3D G3DSA:3.30.465.10 61 113 1.8E-33 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS16240 eb83ce9e1bc751e68fc7b48b85f87553 329 Gene3D G3DSA:3.30.465.10 157 219 1.8E-33 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS26915 933cc2ec49753678929906b0cd4b410f 272 Pfam PF00482 Type II secretion system (T2SS), protein F 134 256 7.2E-14 T 17-03-2017 IPR018076 Type II secretion system F domain SHXM_RS31705 8fe522d1873037f51cf6f1d1bfdf0743 213 SUPERFAMILY SSF55144 4 191 1.83E-9 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS31705 8fe522d1873037f51cf6f1d1bfdf0743 213 Gene3D G3DSA:3.90.1140.10 6 195 2.1E-7 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 SUPERFAMILY SSF50447 5 212 1.59E-79 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 ProSitePatterns PS00474 Ribosomal protein L3 signature. 105 128 - T 17-03-2017 IPR019926 Ribosomal protein L3, conserved site SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 Gene3D G3DSA:4.10.960.10 80 161 2.0E-32 T 17-03-2017 SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 Hamap MF_01325_B 50S ribosomal protein L3 [rplC]. 5 211 39.84 T 17-03-2017 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 Pfam PF00297 Ribosomal protein L3 98 186 4.3E-14 T 17-03-2017 IPR000597 Ribosomal protein L3 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 Gene3D G3DSA:2.40.30.10 162 211 4.4E-12 T 17-03-2017 SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 Gene3D G3DSA:2.40.30.10 7 36 4.4E-12 T 17-03-2017 SHXM_RS31165 bbcdc216cf03e23f3c64d16c68fdcae6 214 TIGRFAM TIGR03625 L3_bact: 50S ribosomal protein uL3 7 208 1.4E-89 T 17-03-2017 IPR019927 Ribosomal protein L3, bacterial/organelle-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS25195 12c960fd6a7cea21010ee2e4f27fc028 233 Gene3D G3DSA:3.90.1570.10 63 207 4.2E-22 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS25195 12c960fd6a7cea21010ee2e4f27fc028 233 SUPERFAMILY SSF52980 58 227 5.9E-21 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS25195 12c960fd6a7cea21010ee2e4f27fc028 233 Pfam PF05685 Putative restriction endonuclease 62 227 4.6E-24 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS47260 790c6928b1f14abf224fed9f34b04557 202 SUPERFAMILY SSF46689 6 78 4.59E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47260 790c6928b1f14abf224fed9f34b04557 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 64 6.1E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47260 790c6928b1f14abf224fed9f34b04557 202 Gene3D G3DSA:1.10.357.10 60 184 9.5E-12 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47260 790c6928b1f14abf224fed9f34b04557 202 Gene3D G3DSA:1.10.10.60 3 59 4.1E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47260 790c6928b1f14abf224fed9f34b04557 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 2.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47260 790c6928b1f14abf224fed9f34b04557 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 2.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36840 f12e71de40da4c8ec65b219a0518245a 320 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 140 313 2.6E-9 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36840 f12e71de40da4c8ec65b219a0518245a 320 SUPERFAMILY SSF161098 38 320 1.7E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36840 f12e71de40da4c8ec65b219a0518245a 320 Gene3D G3DSA:1.10.3720.10 37 307 2.0E-43 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 SMART SM00382 51 248 1.5E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 35 291 2.4E-111 T 17-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 Pfam PF00571 CBS domain 303 351 3.1E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 Gene3D G3DSA:3.40.50.300 36 263 4.5E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 Pfam PF00005 ABC transporter 44 190 7.9E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 ProSitePatterns PS00211 ABC transporters family signature. 163 177 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 SUPERFAMILY SSF52540 41 268 2.89E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 SUPERFAMILY SSF54631 295 351 6.81E-6 T 17-03-2017 SHXM_RS15825 7ac806f50b59b489cccf11c6a11827be 382 Gene3D G3DSA:3.10.580.10 268 351 1.4E-6 T 17-03-2017 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 SUPERFAMILY SSF53850 88 281 3.38E-29 T 17-03-2017 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 63 5.9E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 Gene3D G3DSA:3.40.190.10 86 183 1.1E-20 T 17-03-2017 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 1.4E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 1.4E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 1.4E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 SUPERFAMILY SSF46785 1 109 3.14E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 Gene3D G3DSA:1.10.10.10 2 80 1.8E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 Gene3D G3DSA:3.40.190.10 184 228 3.9E-7 T 17-03-2017 SHXM_RS14300 24e441253bb4a25a1092a981fd7a2074 297 Pfam PF03466 LysR substrate binding domain 87 275 5.7E-30 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS26020 da6ddaff299992d764ea525a7200d4b0 264 Hamap MF_00108 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ispD]. 18 258 28.9 T 17-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 SHXM_RS26020 da6ddaff299992d764ea525a7200d4b0 264 TIGRFAM TIGR00453 ispD: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 21 255 3.7E-70 T 17-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 SHXM_RS26020 da6ddaff299992d764ea525a7200d4b0 264 Gene3D G3DSA:3.90.550.10 18 260 2.4E-67 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS26020 da6ddaff299992d764ea525a7200d4b0 264 ProSitePatterns PS01295 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. 123 130 - T 17-03-2017 IPR018294 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, conserved site GO:0003824|GO:0008299 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 SHXM_RS26020 da6ddaff299992d764ea525a7200d4b0 264 SUPERFAMILY SSF53448 20 255 5.86E-51 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS26020 da6ddaff299992d764ea525a7200d4b0 264 Pfam PF01128 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 20 256 1.3E-66 T 17-03-2017 IPR001228 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299|GO:0050518 KEGG: 00900+2.7.7.60|MetaCyc: PWY-7560 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 Gene3D G3DSA:3.40.640.10 52 272 1.6E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 Gene3D G3DSA:3.90.1150.10 273 394 5.6E-34 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 228 252 1.3E-12 T 17-03-2017 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 58 74 1.3E-12 T 17-03-2017 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 93 113 1.3E-12 T 17-03-2017 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 162 186 1.3E-12 T 17-03-2017 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 115 136 1.3E-12 T 17-03-2017 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 234 247 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 Pfam PF00155 Aminotransferase class I and II 32 386 3.1E-65 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS11905 ef66d15e6e5b7bd5b7b9cdcc11622d90 402 SUPERFAMILY SSF53383 1 392 9.35E-105 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS01200 8ca7c28d1602c9f6e17dde731a75e935 225 Pfam PF01987 Mitochondrial biogenesis AIM24 4 207 1.2E-46 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS01200 8ca7c28d1602c9f6e17dde731a75e935 225 SUPERFAMILY SSF51219 1 218 2.62E-53 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS01200 8ca7c28d1602c9f6e17dde731a75e935 225 TIGRFAM TIGR00266 TIGR00266: TIGR00266 family protein 1 221 2.7E-55 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS01200 8ca7c28d1602c9f6e17dde731a75e935 225 Gene3D G3DSA:3.60.160.10 1 223 2.1E-59 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5072 5087 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF08659 KR domain 1219 1397 1.8E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF08659 KR domain 4752 4930 7.6E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF08659 KR domain 2981 3159 8.5E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00698 Acyl transferase domain 572 885 1.3E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00698 Acyl transferase domain 2135 2447 3.2E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00698 Acyl transferase domain 3890 4213 2.9E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3737 3852 9.3E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 534 1.3E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1978 2093 1.4E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.50.720 4751 4949 4.4E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF52151 4076 4173 9.68E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF52151 3887 4015 9.68E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF55048 4014 4075 1.28E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00550 Phosphopantetheine attachment site 1510 1576 9.5E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00550 Phosphopantetheine attachment site 3268 3334 1.4E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00550 Phosphopantetheine attachment site 5047 5113 6.2E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF55048 696 757 4.32E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3293 3308 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF53901 30 399 3.95E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00823 Phosphopantetheine attachment site 3266 3338 1.6E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00823 Phosphopantetheine attachment site 5045 5117 3.9E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00823 Phosphopantetheine attachment site 1508 1580 2.7E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:1.10.1200.10 5042 5117 1.7E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:1.10.1200.10 1508 1581 1.9E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:1.10.1200.10 3264 3339 1.3E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF51735 2779 2966 2.13E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF55048 2259 2320 1.1E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF47336 1505 1615 3.53E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3617 3734 7.3E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 1.4E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1858 1975 5.4E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF53901 3355 3731 6.53E-107 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF14765 Polyketide synthase dehydratase 2496 2772 1.4E-52 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF14765 Polyketide synthase dehydratase 4260 4537 6.0E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF51735 2980 3189 3.06E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF47336 3261 3374 2.22E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.47.10 1602 1862 7.6E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.47.10 36 296 3.6E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.47.10 3361 3621 3.2E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2136 2428 2.0E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 573 868 1.4E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3891 4193 2.6E-123 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF52151 570 691 5.23E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF52151 750 854 5.23E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.47.10 3622 3787 1.0E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.47.10 297 464 1.1E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.47.10 1863 2028 6.2E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM01294 5046 5113 6.0E-7 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM01294 3267 3334 1.1E-5 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM01294 1509 1576 8.0E-7 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.50.720 1217 1408 2.9E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.50.720 2981 3176 1.4E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.366.10 4075 4196 1.1E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.366.10 2320 2432 2.5E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.366.10 567 691 1.7E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.366.10 757 871 1.7E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.366.10 2130 2254 2.5E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.40.366.10 3885 4009 1.1E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF51735 984 1206 6.4E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF08990 Erythronolide synthase docking 2 27 2.0E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3522 3538 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00826 2496 2660 3.8E-80 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00826 4260 4426 1.7E-84 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF51735 4751 4949 1.03E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00825 Beta-ketoacyl synthase 1602 2028 4.2E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00825 Beta-ketoacyl synthase 36 465 1.7E-214 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00825 Beta-ketoacyl synthase 3361 3787 1.0E-236 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1535 1550 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1763 1779 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF47336 5038 5120 2.88E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF51735 1217 1434 5.17E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.30.70.250 2259 2319 8.5E-7 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.30.70.250 4015 4074 8.9E-8 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Gene3D G3DSA:3.30.70.250 696 756 2.6E-7 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1219 1398 1.5E-56 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2981 3161 1.3E-57 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4752 4932 5.9E-58 T 17-03-2017 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1600 1850 9.6E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3359 3609 8.6E-96 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 1.0E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF53901 1598 1972 2.55E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF51735 4545 4736 5.64E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF52151 2313 2419 1.1E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22160 c0092164d8baa97062c2cb585f4605a1 5201 SUPERFAMILY SSF52151 2133 2254 1.1E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 SUPERFAMILY SSF55021 255 325 4.12E-6 T 17-03-2017 SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 Pfam PF00005 ABC transporter 21 169 6.6E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 SMART SM00382 30 218 6.3E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 Gene3D G3DSA:3.40.50.300 1 234 1.4E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 Gene3D G3DSA:3.30.70.260 255 323 1.7E-5 T 17-03-2017 SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 SUPERFAMILY SSF52540 1 236 5.09E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01965 0aa914a9f2528be923a845e2223a129f 355 Pfam PF09383 NIL domain 257 318 3.1E-7 T 17-03-2017 IPR018449 NIL domain SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 Hamap MF_00375 Glutamate-1-semialdehyde 2,1-aminomutase [hemL]. 12 433 96.961 T 17-03-2017 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188 SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 Pfam PF00202 Aminotransferase class-III 42 426 4.7E-82 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 243 279 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 TIGRFAM TIGR00713 hemL: glutamate-1-semialdehyde-2,1-aminomutase 13 426 4.9E-179 T 17-03-2017 IPR004639 Tetrapyrrole biosynthesis, glutamate-1-semialdehyde aminotransferase GO:0033014|GO:0042286 KEGG: 00860+5.4.3.8|MetaCyc: PWY-5188 SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 SUPERFAMILY SSF53383 11 429 4.75E-119 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 Gene3D G3DSA:3.90.1150.10 327 429 3.3E-38 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 Gene3D G3DSA:3.90.1150.10 11 78 3.3E-38 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS30595 c3b8a0a4e7df80c53c5e9ab6260f7777 438 Gene3D G3DSA:3.40.640.10 79 325 1.9E-76 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS49250 809f6aad219026c452d89300880ed784 419 SMART SM00564 152 186 66.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS49250 809f6aad219026c452d89300880ed784 419 SMART SM00564 362 396 35.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS49250 809f6aad219026c452d89300880ed784 419 SMART SM00564 110 143 100.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS49250 809f6aad219026c452d89300880ed784 419 Gene3D G3DSA:2.130.10.10 108 406 1.7E-37 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS49250 809f6aad219026c452d89300880ed784 419 SUPERFAMILY SSF50974 108 406 1.36E-41 T 17-03-2017 IPR011045 Nitrous oxide reductase, N-terminal Reactome: R-HSA-114608 SHXM_RS49250 809f6aad219026c452d89300880ed784 419 Pfam PF13360 PQQ-like domain 118 190 6.2E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS11710 dd637916a525720aac0bb797e372b085 212 Gene3D G3DSA:3.40.50.1820 18 201 3.7E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11710 dd637916a525720aac0bb797e372b085 212 Pfam PF06821 Serine hydrolase 20 196 5.0E-26 T 17-03-2017 IPR010662 Putative hydrolase RBBP9/YdeN GO:0016787 SHXM_RS11710 dd637916a525720aac0bb797e372b085 212 SUPERFAMILY SSF53474 20 201 4.77E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49080 5c4799aee19c4e749fd1a6b1f6c8f774 280 Pfam PF01609 Transposase DDE domain 105 211 4.1E-11 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS49080 5c4799aee19c4e749fd1a6b1f6c8f774 280 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 8 87 1.2E-10 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 Gene3D G3DSA:2.60.40.1180 382 477 1.3E-29 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 SUPERFAMILY SSF51445 54 162 2.0E-60 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 SUPERFAMILY SSF51445 200 388 2.0E-60 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 Pfam PF16499 Alpha galactosidase A 207 437 1.1E-26 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 Pfam PF16499 Alpha galactosidase A 57 188 1.0E-16 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 SUPERFAMILY SSF49785 486 605 4.57E-15 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 SUPERFAMILY SSF51011 393 476 2.8E-19 T 17-03-2017 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 PRINTS PR00740 Glycosyl hydrolase family 27 signature 144 165 6.2E-16 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 PRINTS PR00740 Glycosyl hydrolase family 27 signature 321 340 6.2E-16 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 PRINTS PR00740 Glycosyl hydrolase family 27 signature 51 70 6.2E-16 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 PRINTS PR00740 Glycosyl hydrolase family 27 signature 249 267 6.2E-16 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 Gene3D G3DSA:2.60.120.260 486 605 8.1E-20 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 Pfam PF16990 Carbohydrate binding module (family 35) 489 605 4.5E-10 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS46430 ec811a36f91c9ad5942faf3e2125b068 609 Gene3D G3DSA:3.20.20.70 52 381 1.6E-84 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 Pfam PF13249 Squalene-hopene cyclase N-terminal domain 26 311 1.1E-122 T 17-03-2017 IPR032697 Squalene cyclase, N-terminal Reactome: R-HSA-191273|Reactome: R-HSA-2426168 SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 Gene3D G3DSA:1.50.10.20 47 305 1.8E-66 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 Gene3D G3DSA:1.50.10.20 306 636 4.2E-116 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 TIGRFAM TIGR01787 squalene_cyclas: squalene/oxidosqualene cyclases 25 635 1.1E-182 T 17-03-2017 IPR018333 Squalene cyclase GO:0016866 Reactome: R-HSA-191273|Reactome: R-HSA-2426168 SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 Pfam PF13243 Squalene-hopene cyclase C-terminal domain 321 636 1.2E-138 T 17-03-2017 IPR032696 Squalene cyclase, C-terminal Reactome: R-HSA-191273|Reactome: R-HSA-2426168 SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 SUPERFAMILY SSF48239 49 315 5.23E-74 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 SUPERFAMILY SSF48239 308 637 3.14E-106 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS13325 b1a8959ca331f6e7efb685111aacde8c 648 TIGRFAM TIGR01507 hopene_cyclase: squalene-hopene cyclase 15 637 2.0E-239 T 17-03-2017 IPR006400 Squalene hopene cyclase GO:0016866|GO:0019746 KEGG: 00030+4.2.1.12|KEGG: 00909+4.2.1.129+5.4.99.17|MetaCyc: PWY-6098|MetaCyc: PWY-7072 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF13193 AMP-binding enzyme C-terminal domain 938 1009 3.6E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF13193 AMP-binding enzyme C-terminal domain 3556 3627 3.7E-7 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF13193 AMP-binding enzyme C-terminal domain 2486 2562 1.3E-11 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF13193 AMP-binding enzyme C-terminal domain 4626 4702 1.2E-14 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF13745 HxxPF-repeated domain 2991 3087 1.5E-30 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF13745 HxxPF-repeated domain 4063 4158 3.8E-27 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 76 276 2.11E-43 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00455 Putative AMP-binding domain signature. 4363 4374 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1444 1603 1.7E-40 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.30.300.30 925 1039 4.6E-40 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.30.300.30 2473 2591 8.1E-43 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.30.300.30 4613 4731 2.9E-41 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.30.300.30 3543 3657 8.8E-35 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 2857 3128 4.89E-62 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 262 523 4.89E-59 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 1113 1318 2.56E-30 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:2.30.38.10 2389 2468 1.7E-24 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:2.30.38.10 3456 3538 3.1E-23 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:2.30.38.10 842 919 1.3E-26 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:2.30.38.10 4531 4608 1.4E-27 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 3740 3917 1.0E-47 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00455 Putative AMP-binding domain signature. 3284 3295 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 704 841 8.1E-32 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 4400 4530 1.6E-26 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF56801 4171 4739 6.15E-150 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2611 2626 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF56801 3100 3667 9.03E-147 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:1.10.1200.10 4732 4796 1.9E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:1.10.1200.10 3658 3720 2.5E-29 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:1.10.1200.10 1040 1103 2.7E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:1.10.1200.10 2592 2656 6.3E-28 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF47336 4720 4792 5.23E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4233 4642 4.1E-127 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2097 2502 2.3E-128 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 557 954 4.7E-130 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3162 3572 3.5E-122 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3678 3693 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 2230 2388 5.6E-33 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 3294 3452 2.9E-43 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1058 1073 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00975 Thioesterase domain 4817 4946 2.9E-25 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SMART SM00824 Thioesterase 4819 5072 0.0031 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 1798 2037 1.11E-55 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SMART SM00823 Phosphopantetheine attachment site 2587 2656 1.5E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SMART SM00823 Phosphopantetheine attachment site 1034 1102 2.1E-5 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SMART SM00823 Phosphopantetheine attachment site 3654 3723 1.6E-12 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SMART SM00823 Phosphopantetheine attachment site 4727 4796 1.6E-9 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF47336 1027 1096 8.38E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF56801 495 1047 7.06E-154 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 2071 2229 1.8E-45 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00550 Phosphopantetheine attachment site 4729 4792 1.4E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00550 Phosphopantetheine attachment site 3656 3717 1.7E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00550 Phosphopantetheine attachment site 2589 2652 1.5E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00550 Phosphopantetheine attachment site 1036 1097 1.1E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF56801 2033 2600 6.93E-150 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 1611 1811 4.89E-42 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4751 4766 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF47336 2580 2653 3.01E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 1310 1580 1.33E-27 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.1820 4802 4920 2.2E-47 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.1820 5002 5069 2.2E-47 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF47336 3647 3719 1.57E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 2673 2845 1.33E-49 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2224 2235 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF52777 3930 4200 1.33E-58 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00668 Condensation domain 2671 2969 4.6E-59 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00668 Condensation domain 1613 1907 2.1E-61 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00668 Condensation domain 1117 1428 2.4E-30 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00668 Condensation domain 3736 4041 3.5E-55 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00668 Condensation domain 79 374 3.2E-63 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00501 AMP-binding enzyme 2075 2478 2.0E-90 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00501 AMP-binding enzyme 3141 3548 2.7E-85 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00501 AMP-binding enzyme 4212 4618 1.5E-88 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Pfam PF00501 AMP-binding enzyme 536 930 1.1E-92 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 4207 4386 5.1E-51 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 532 703 6.7E-48 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 Gene3D G3DSA:3.40.50.980 3137 3293 3.3E-36 T 17-03-2017 SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 ProSitePatterns PS00455 Putative AMP-binding domain signature. 682 693 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02195 7b40b95c05b791a6b9810d3919a66872 5072 SUPERFAMILY SSF53474 4797 5068 1.51E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:3.30.30.30 39 105 1.2E-13 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:3.30.420.40 106 170 2.2E-56 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:3.30.420.40 4 38 2.2E-56 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Pfam PF00012 Hsp70 protein 4 579 1.6E-241 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2. 172 185 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:3.90.640.10 206 291 1.6E-28 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 4 579 5.7E-276 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 SUPERFAMILY SSF53067 167 358 2.78E-66 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 SUPERFAMILY SSF100920 360 516 1.96E-58 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:2.60.34.10 366 508 1.1E-73 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:3.30.420.40 295 337 2.3E-36 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:3.30.420.40 171 205 2.3E-36 T 17-03-2017 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Gene3D G3DSA:1.20.1270.10 509 579 6.1E-24 T 17-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 1 622 35.979 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 7 14 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 3 16 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 119 139 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 445 461 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 178 188 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 54 62 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 310 326 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 341 361 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 364 383 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 PRINTS PR00301 70kDa heat shock protein signature 31 43 1.5E-73 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS06730 5bb067de395ed9862e696350d5751742 639 SUPERFAMILY SSF53067 2 164 3.89E-56 T 17-03-2017 SHXM_RS14980 8d80d999f3335617e036eada0284af41 316 SUPERFAMILY SSF51735 4 306 1.86E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14980 8d80d999f3335617e036eada0284af41 316 Pfam PF05368 NmrA-like family 7 251 3.8E-43 T 17-03-2017 IPR008030 NmrA-like domain Reactome: R-HSA-70635 SHXM_RS14980 8d80d999f3335617e036eada0284af41 316 Gene3D G3DSA:3.40.50.720 1 245 1.0E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38610 be5786b327949b697431a39793121c89 319 Gene3D G3DSA:2.60.120.650 65 219 7.2E-29 T 17-03-2017 SHXM_RS38610 be5786b327949b697431a39793121c89 319 SUPERFAMILY SSF51197 66 278 4.12E-34 T 17-03-2017 SHXM_RS38610 be5786b327949b697431a39793121c89 319 Pfam PF08007 Cupin superfamily protein 117 252 1.5E-22 T 17-03-2017 IPR003347 JmjC domain SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 4.2E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 4.2E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 4.2E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 SUPERFAMILY SSF46785 1 85 3.92E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 Gene3D G3DSA:1.10.10.10 1 84 2.0E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 SUPERFAMILY SSF53850 88 295 2.51E-36 T 17-03-2017 SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 Pfam PF03466 LysR substrate binding domain 87 294 2.7E-39 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 Gene3D G3DSA:3.40.190.10 88 177 7.9E-29 T 17-03-2017 SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 Gene3D G3DSA:3.40.190.10 178 267 5.8E-28 T 17-03-2017 SHXM_RS23770 77ffad357fe562fbfcf306d06de8483b 297 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 6.1E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 4.6E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 4.6E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 3.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 3.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 3.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 3.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 Gene3D G3DSA:3.40.50.720 3 234 9.0E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 Pfam PF00106 short chain dehydrogenase 7 197 3.7E-51 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04050 6ae598141cd179a071226339acbfd782 245 SUPERFAMILY SSF51735 2 234 4.53E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34585 cfb76e7822e5b7bdf581cad06ab4f094 423 Pfam PF01547 Bacterial extracellular solute-binding protein 48 333 1.8E-37 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS34585 cfb76e7822e5b7bdf581cad06ab4f094 423 Gene3D G3DSA:3.40.190.10 38 163 8.0E-24 T 17-03-2017 SHXM_RS34585 cfb76e7822e5b7bdf581cad06ab4f094 423 SUPERFAMILY SSF53850 19 420 4.76E-67 T 17-03-2017 SHXM_RS34585 cfb76e7822e5b7bdf581cad06ab4f094 423 Gene3D G3DSA:3.40.190.10 164 353 1.8E-33 T 17-03-2017 SHXM_RS02915 4c0d511802d1134a089206df784cc409 272 Gene3D G3DSA:3.40.50.150 5 247 4.2E-43 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02915 4c0d511802d1134a089206df784cc409 272 SUPERFAMILY SSF53335 12 239 1.77E-61 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02915 4c0d511802d1134a089206df784cc409 272 Pfam PF04072 Leucine carboxyl methyltransferase 19 175 4.3E-20 T 17-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 SHXM_RS02915 4c0d511802d1134a089206df784cc409 272 PIRSF PIRSF028177 1 272 4.5E-84 T 17-03-2017 IPR016874 Tetracenomycin polyketide synthesis O-methyltransferase TcmP GO:0017000|GO:1901106 SHXM_RS32570 a96eb3cb49891249773c6bb84c544869 256 SUPERFAMILY SSF52540 9 231 8.43E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32570 a96eb3cb49891249773c6bb84c544869 256 SMART SM00382 36 225 2.8E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32570 a96eb3cb49891249773c6bb84c544869 256 TIGRFAM TIGR01166 cbiO: cobalt ABC transporter, ATP-binding protein 20 201 2.3E-64 T 17-03-2017 IPR005876 Cobalt transport protein ATP-binding subunit GO:0006824 SHXM_RS32570 a96eb3cb49891249773c6bb84c544869 256 ProSitePatterns PS00211 ABC transporters family signature. 145 159 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS32570 a96eb3cb49891249773c6bb84c544869 256 Pfam PF00005 ABC transporter 29 172 2.1E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS32570 a96eb3cb49891249773c6bb84c544869 256 Gene3D G3DSA:3.40.50.300 4 233 8.9E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18165 ba6cb5656492c8b0442e45e6bba462bc 305 Pfam PF00005 ABC transporter 29 188 5.6E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS18165 ba6cb5656492c8b0442e45e6bba462bc 305 SMART SM00382 37 227 8.6E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS18165 ba6cb5656492c8b0442e45e6bba462bc 305 Pfam PF12399 Branched-chain amino acid ATP-binding cassette transporter 236 258 2.3E-6 T 17-03-2017 IPR032823 Branched-chain amino acid ATP-binding cassette transporter, C-terminal SHXM_RS18165 ba6cb5656492c8b0442e45e6bba462bc 305 Gene3D G3DSA:3.40.50.300 9 255 1.4E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18165 ba6cb5656492c8b0442e45e6bba462bc 305 SUPERFAMILY SSF52540 11 258 1.66E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45880 85b7c8e8bc42a503f6cb53c578508d36 62 Gene3D G3DSA:1.10.10.10 4 61 2.5E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45880 85b7c8e8bc42a503f6cb53c578508d36 62 SUPERFAMILY SSF46894 4 49 7.14E-9 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS45880 85b7c8e8bc42a503f6cb53c578508d36 62 Pfam PF00196 Bacterial regulatory proteins, luxR family 4 40 6.8E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 Pfam PF13649 Methyltransferase domain 89 187 1.2E-12 T 17-03-2017 SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 Gene3D G3DSA:3.40.50.150 68 278 4.1E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 SUPERFAMILY SSF53335 57 289 5.32E-36 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 Pfam PF08241 Methyltransferase domain 375 473 8.3E-21 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 SUPERFAMILY SSF53335 315 584 7.23E-51 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 Gene3D G3DSA:3.40.50.150 346 484 1.5E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 Gene3D G3DSA:1.10.287.840 485 577 9.8E-37 T 17-03-2017 IPR023143 Mycolic acid cyclopropane synthase-like domain SHXM_RS36050 43fd599fdd1d2ec911a86a95d9b5f979 584 Gene3D G3DSA:1.10.287.840 313 345 9.8E-37 T 17-03-2017 IPR023143 Mycolic acid cyclopropane synthase-like domain SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 SUPERFAMILY SSF100950 129 293 1.0E-36 T 17-03-2017 SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 SUPERFAMILY SSF100950 58 83 1.0E-36 T 17-03-2017 SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 SUPERFAMILY SSF54862 289 392 2.09E-14 T 17-03-2017 SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 Pfam PF13183 4Fe-4S dicluster domain 308 377 1.8E-9 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 311 322 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 64 292 9.3E-50 T 17-03-2017 IPR003741 LUD domain SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 Gene3D G3DSA:1.10.1060.10 307 392 2.9E-11 T 17-03-2017 SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 Pfam PF11870 Domain of unknown function (DUF3390) 386 477 4.6E-15 T 17-03-2017 IPR024569 4Fe-4S binding protein, C-terminal SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 Gene3D G3DSA:3.40.50.10420 59 122 3.4E-46 T 17-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SHXM_RS11420 fec91d32b50b1bcb8e74e88a46c1af7f 489 Gene3D G3DSA:3.40.50.10420 190 293 3.4E-46 T 17-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Gene3D G3DSA:3.40.1110.10 478 587 2.7E-24 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Gene3D G3DSA:3.30.70.100 20 86 1.1E-21 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF81665 709 729 9.29E-12 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF81665 230 264 9.29E-12 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF81665 361 454 9.29E-12 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF56784 458 478 8.25E-55 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF56784 517 760 8.25E-55 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 ProSitePatterns PS01047 Heavy-metal-associated domain. 28 56 - T 17-03-2017 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Gene3D G3DSA:2.70.150.10 228 361 2.8E-26 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF81653 266 360 5.49E-23 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Gene3D G3DSA:3.40.50.1000 588 728 6.0E-52 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Gene3D G3DSA:3.40.50.1000 431 476 6.0E-52 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 632 648 1.1E-7 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 691 716 1.1E-7 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 660 676 1.1E-7 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 ProSitePatterns PS01229 Hypothetical cof family signature 2. 660 682 - T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 179 762 3.3E-176 T 17-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 SUPERFAMILY SSF55008 20 86 8.9E-18 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 224 763 2.0E-152 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 310 324 1.5E-20 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 460 474 1.5E-20 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 607 617 1.5E-20 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 683 695 1.5E-20 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 660 679 1.5E-20 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Pfam PF00403 Heavy-metal-associated domain 27 84 1.7E-12 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 234 741 5.9E-84 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Pfam PF00702 haloacid dehalogenase-like hydrolase 456 674 5.2E-45 T 17-03-2017 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 Pfam PF00122 E1-E2 ATPase 233 451 1.6E-63 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS22310 fd98503b573faf0b8c725cb74e3a4a38 769 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 462 468 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 SUPERFAMILY SSF46785 2 84 1.91E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 Gene3D G3DSA:3.40.190.10 90 174 1.2E-21 T 17-03-2017 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 Gene3D G3DSA:3.40.190.10 175 264 5.7E-14 T 17-03-2017 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 Pfam PF03466 LysR substrate binding domain 87 292 4.5E-34 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 SUPERFAMILY SSF53850 88 295 2.58E-33 T 17-03-2017 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 Gene3D G3DSA:1.10.10.10 2 86 1.7E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 2.0E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 2.0E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 2.0E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49535 bfeef12cbc915d3d57e75bc1291699c5 297 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 2.9E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS32895 dad683e63df349570467337a4b9e9b44 153 SUPERFAMILY SSF46785 12 152 7.35E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32895 dad683e63df349570467337a4b9e9b44 153 Pfam PF01047 MarR family 44 100 1.8E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32895 dad683e63df349570467337a4b9e9b44 153 Gene3D G3DSA:1.10.10.10 17 151 1.5E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32895 dad683e63df349570467337a4b9e9b44 153 SMART SM00347 37 137 1.3E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 PIRSF PIRSF000386 1 259 2.1E-93 T 17-03-2017 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 Gene3D G3DSA:3.40.1280.10 1 167 1.1E-62 T 17-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 SUPERFAMILY SSF75217 1 244 2.01E-82 T 17-03-2017 IPR029028 Alpha/beta knot methyltransferases SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 Gene3D G3DSA:1.10.1270.20 168 257 3.0E-28 T 17-03-2017 IPR023148 tRNA (guanine-N1-)-methyltransferase, C-terminal GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 Hamap MF_00605 tRNA (guanine-N(1)-)-methyltransferase [trmD]. 1 276 100.35 T 17-03-2017 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 TIGRFAM TIGR00088 trmD: tRNA (guanine(37)-N(1))-methyltransferase 1 239 7.5E-65 T 17-03-2017 IPR002649 tRNA (guanine-N1-)-methyltransferase, bacteria GO:0008033|GO:0052906 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS36585 5e5651e9454dffc367ab1cc6dae93b10 276 Pfam PF01746 tRNA (Guanine-1)-methyltransferase 22 232 6.3E-69 T 17-03-2017 IPR016009 tRNA methyltransferase TRMD/TRM10-type domain KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829|MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS38710 007a6a426a8851467a89225f216a0cf4 306 Gene3D G3DSA:1.10.3720.10 96 287 2.1E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38710 007a6a426a8851467a89225f216a0cf4 306 SUPERFAMILY SSF161098 97 285 8.63E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38710 007a6a426a8851467a89225f216a0cf4 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 121 287 3.0E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 209 3.7E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 1.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 1.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 1.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 SUPERFAMILY SSF46894 138 214 1.16E-19 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 SUPERFAMILY SSF52172 2 132 2.85E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 ProSitePatterns PS00622 LuxR-type HTH domain signature. 169 196 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 Gene3D G3DSA:1.10.10.10 120 214 9.1E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 Pfam PF00072 Response regulator receiver domain 5 116 2.7E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 Gene3D G3DSA:3.40.50.2300 2 119 3.2E-37 T 17-03-2017 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 SMART SM00448 2 115 1.2E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS40300 2a69449e31eb0d6f1f1575716d5ec149 217 SMART SM00421 152 209 4.0E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39435 895322686138f723856b54d7f7fc0161 125 SUPERFAMILY SSF48498 1 107 2.09E-19 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS39435 895322686138f723856b54d7f7fc0161 125 Pfam PF13977 Bacterial transcriptional repressor 24 85 2.7E-6 T 17-03-2017 SHXM_RS39435 895322686138f723856b54d7f7fc0161 125 Gene3D G3DSA:1.10.357.10 2 107 4.2E-18 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 Pfam PF00107 Zinc-binding dehydrogenase 159 248 3.0E-20 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 Gene3D G3DSA:3.90.180.10 13 153 1.2E-35 T 17-03-2017 IPR011032 GroES-like SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 SUPERFAMILY SSF51735 121 270 2.7E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 Gene3D G3DSA:3.40.50.720 154 248 3.2E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 SMART SM00829 16 343 6.3E-15 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 36 95 1.2E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS23910 4192d079050c309677b5599918af3ac4 347 SUPERFAMILY SSF50129 20 149 3.2E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 ProSitePatterns PS01075 Acetate and butyrate kinases family signature 1. 6 17 - T 17-03-2017 IPR023865 Aliphatic acid kinase, short-chain, conserved site GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 Pfam PF00871 Acetokinase family 6 372 1.0E-139 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 Gene3D G3DSA:3.30.420.40 5 188 2.0E-12 T 17-03-2017 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 TIGRFAM TIGR00016 ackA: acetate kinase 42 378 6.8E-128 T 17-03-2017 IPR004372 Acetate/propionate kinase GO:0006082|GO:0016301|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 SUPERFAMILY SSF53067 141 378 2.07E-81 T 17-03-2017 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PRINTS PR00471 Acetate kinase family signature 305 321 2.0E-43 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PRINTS PR00471 Acetate kinase family signature 6 17 2.0E-43 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PRINTS PR00471 Acetate kinase family signature 157 170 2.0E-43 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PRINTS PR00471 Acetate kinase family signature 360 372 2.0E-43 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PRINTS PR00471 Acetate kinase family signature 187 208 2.0E-43 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PRINTS PR00471 Acetate kinase family signature 283 296 2.0E-43 T 17-03-2017 IPR000890 Aliphatic acid kinase, short-chain GO:0005622|GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 ProSitePatterns PS01076 Acetate and butyrate kinases family signature 2. 187 204 - T 17-03-2017 IPR023865 Aliphatic acid kinase, short-chain, conserved site GO:0008152|GO:0016301|GO:0016310|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 SUPERFAMILY SSF53067 5 180 5.83E-62 T 17-03-2017 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 Hamap MF_00020 Acetate kinase [ackA]. 1 381 165.957 T 17-03-2017 IPR004372 Acetate/propionate kinase GO:0006082|GO:0016301|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 PIRSF PIRSF000722 3 381 2.1E-133 T 17-03-2017 IPR004372 Acetate/propionate kinase GO:0006082|GO:0016301|GO:0016774 KEGG: 00430+2.7.2.1|KEGG: 00620+2.7.2.1|KEGG: 00640+2.7.2.1|KEGG: 00680+2.7.2.1|KEGG: 00720+2.7.2.1|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497 SHXM_RS35525 2e5f52d25ed2ac3fbe95493615e12021 381 Gene3D G3DSA:3.30.420.40 189 378 4.1E-76 T 17-03-2017 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Pfam PF00750 tRNA synthetases class I (R) 123 463 2.7E-101 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Hamap MF_00123 Arginine--tRNA ligase [argS]. 9 595 25.945 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 132 143 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 SMART SM01016 9 96 1.6E-21 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 TIGRFAM TIGR00456 argS: arginine--tRNA ligase 14 595 2.3E-131 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 SUPERFAMILY SSF55190 8 106 3.4E-13 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 PRINTS PR01038 Arginyl-tRNA synthetase signature 319 340 2.9E-24 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 PRINTS PR01038 Arginyl-tRNA synthetase signature 163 176 2.9E-24 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 PRINTS PR01038 Arginyl-tRNA synthetase signature 139 155 2.9E-24 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 PRINTS PR01038 Arginyl-tRNA synthetase signature 124 139 2.9E-24 T 17-03-2017 IPR001278 Arginine-tRNA ligase GO:0004814|GO:0005524|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Gene3D G3DSA:3.30.1360.70 6 114 1.1E-24 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Gene3D G3DSA:1.10.730.10 472 595 4.3E-33 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Pfam PF03485 Arginyl tRNA synthetase N terminal domain 12 96 1.0E-13 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 SMART SM00836 478 595 2.1E-37 T 17-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 SUPERFAMILY SSF47323 472 595 4.51E-31 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 SUPERFAMILY SSF52374 120 470 9.38E-85 T 17-03-2017 SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Gene3D G3DSA:3.40.50.620 121 470 4.0E-101 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS30525 c8b77c68996546ae2cf83bb9c03aa186 595 Pfam PF05746 DALR anticodon binding domain 478 595 6.1E-31 T 17-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 SUPERFAMILY SSF51905 3 170 3.33E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 SUPERFAMILY SSF51905 271 363 3.33E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 Gene3D G3DSA:3.50.50.60 2 175 7.2E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 Gene3D G3DSA:3.50.50.60 274 352 7.2E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 2.8E-17 T 17-03-2017 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 149 164 2.8E-17 T 17-03-2017 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 284 299 2.8E-17 T 17-03-2017 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 299 315 2.8E-17 T 17-03-2017 SHXM_RS07150 a7f945c0518fc29abb374b932b8f1f16 403 Pfam PF01494 FAD binding domain 2 344 3.8E-26 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS43410 68322b08062dc94ac5c8c5799033279a 211 TIGRFAM TIGR02365 dha_L_ycgS: dihydroxyacetone kinase, L subunit 18 207 1.2E-70 T 17-03-2017 IPR012737 Dihydroxyacetone kinase, subunit L GO:0016772 SHXM_RS43410 68322b08062dc94ac5c8c5799033279a 211 Pfam PF02734 DAK2 domain 41 207 9.8E-53 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS43410 68322b08062dc94ac5c8c5799033279a 211 SMART SM01120 41 208 1.2E-76 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS43410 68322b08062dc94ac5c8c5799033279a 211 SUPERFAMILY SSF101473 10 209 1.31E-57 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 Gene3D G3DSA:3.60.40.10 121 352 8.9E-64 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 SUPERFAMILY SSF46955 4 103 1.5E-22 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 SMART SM00422 4 74 2.7E-18 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 Pfam PF13672 Protein phosphatase 2C 137 306 3.0E-8 T 17-03-2017 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 SUPERFAMILY SSF81606 123 352 2.22E-56 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 Pfam PF13411 MerR HTH family regulatory protein 5 70 2.2E-14 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 SMART SM00332 114 350 8.0E-19 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 SMART SM00331 129 352 7.7E-28 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 ProSitePatterns PS00552 MerR-type HTH domain signature. 7 29 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS46125 3107f6321a571c911ff6ada8dc2eb555 361 Gene3D G3DSA:1.10.1660.10 4 101 2.8E-22 T 17-03-2017 SHXM_RS50730 f22058365c30bfb395283145bc469216 98 Pfam PF00589 Phage integrase family 3 53 3.7E-6 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS50730 f22058365c30bfb395283145bc469216 98 SUPERFAMILY SSF56349 7 67 9.42E-10 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS50730 f22058365c30bfb395283145bc469216 98 Gene3D G3DSA:1.10.443.10 10 70 4.7E-10 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 TIGRFAM TIGR03705 poly_P_kin: polyphosphate kinase 1 67 738 2.9E-249 T 17-03-2017 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Gene3D G3DSA:3.30.1840.10 170 355 1.6E-71 T 17-03-2017 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Gene3D G3DSA:3.30.870.10 384 559 5.3E-77 T 17-03-2017 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 SUPERFAMILY SSF140356 65 169 3.53E-35 T 17-03-2017 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Pfam PF13090 Polyphosphate kinase C-terminal domain 389 737 7.3E-154 T 17-03-2017 IPR025200 Polyphosphate kinase C-terminal domain KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Pfam PF02503 Polyphosphate kinase middle domain 183 373 6.4E-65 T 17-03-2017 IPR024953 Polyphosphate kinase middle domain KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 SUPERFAMILY SSF56024 560 742 1.12E-66 T 17-03-2017 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 SUPERFAMILY SSF143724 171 367 7.85E-64 T 17-03-2017 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 SUPERFAMILY SSF56024 385 556 7.22E-54 T 17-03-2017 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Hamap MF_00347 Polyphosphate kinase [ppk]. 65 741 33.864 T 17-03-2017 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Pfam PF13089 Polyphosphate kinase N-terminal domain 68 174 8.5E-36 T 17-03-2017 IPR025198 Polyphosphate kinase N-terminal domain KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 PIRSF PIRSF015589 53 749 1.3E-279 T 17-03-2017 IPR003414 Polyphosphate kinase GO:0006799|GO:0008976|GO:0009358 KEGG: 00190+2.7.4.1 SHXM_RS26225 1b53377b0ff7d2dabf9dcd5c8b4ca095 749 Gene3D G3DSA:3.30.870.10 560 742 7.8E-72 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3381 3397 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 5193 5209 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM01294 1597 1664 1.3E-6 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM01294 8060 8127 2.1E-5 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM01294 4935 5002 1.5E-5 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM01294 3126 3193 3.0E-7 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM01294 6498 6565 9.6E-8 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 1952 2117 9.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 402 565 1.3E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 3481 3646 9.2E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 6855 7021 7.3E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 5293 5458 7.5E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF47336 3119 3233 2.22E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF47336 4929 5045 3.27E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7767 7949 3.4E-62 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4648 4828 1.4E-51 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6214 6393 1.6E-60 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2839 3018 5.5E-62 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1307 1486 9.7E-65 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 868 968 2.09E-73 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 672 804 2.09E-73 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1689 1939 1.5E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3218 3468 1.8E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5030 5280 4.3E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 138 388 7.7E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6592 6842 2.4E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF53901 1687 2061 4.81E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF55048 7251 7312 6.15E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 7124 7252 1.44E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 7313 7406 1.44E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 4646 4860 1.93E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3476 3593 2.5E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 5288 5405 2.5E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1947 2064 1.9E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 6850 6967 8.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 396 513 7.5E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF53901 5026 5402 1.6E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:1.10.1200.10 1594 1668 5.0E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:1.10.1200.10 40 115 3.0E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:1.10.1200.10 6495 6570 9.5E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:1.10.1200.10 8057 8131 3.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:1.10.1200.10 3122 3197 2.0E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:1.10.1200.10 4931 5007 2.8E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1852 1868 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00698 Acyl transferase domain 676 970 3.2E-57 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00698 Acyl transferase domain 2221 2531 1.3E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00698 Acyl transferase domain 5566 5870 4.9E-57 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00698 Acyl transferase domain 3753 4065 2.5E-57 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00698 Acyl transferase domain 7128 7444 3.4E-61 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF08659 KR domain 1307 1485 6.2E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF08659 KR domain 7767 7948 1.8E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF08659 KR domain 4648 4826 2.6E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF08659 KR domain 2839 3017 5.3E-62 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF08659 KR domain 6214 6392 1.5E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF55048 5690 5751 9.29E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF47336 38 152 2.75E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 5027 5292 6.1E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 137 400 7.8E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 6589 6854 1.8E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4961 4976 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 6755 6771 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1623 1638 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF47336 8056 8137 7.46E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 1308 1535 5.06E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 516 636 2.0E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2067 2183 5.9E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 5408 5509 7.5E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 6970 7091 4.5E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3596 3708 9.8E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 7763 8021 3.24E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 3220 3480 9.2E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.47.10 1691 1951 1.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 6214 6475 3.33E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 4410 4610 6.69E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 2835 3069 3.19E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.30.70.250 2345 2405 2.1E-6 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.30.70.250 5690 5750 8.7E-7 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.30.70.250 7251 7311 2.5E-5 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.30.70.250 803 866 1.5E-6 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.30.70.250 3877 3937 3.2E-7 T 17-03-2017 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00012 Phosphopantetheine attachment site. 8086 8101 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00826 4117 4284 2.3E-84 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF55048 803 867 1.31E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF55048 3877 3938 6.28E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF14765 Polyketide synthase dehydratase 4117 4403 1.6E-53 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 5975 6202 5.12E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6524 6539 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00550 Phosphopantetheine attachment site 1598 1664 7.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00550 Phosphopantetheine attachment site 3127 3193 6.2E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00550 Phosphopantetheine attachment site 45 111 1.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00550 Phosphopantetheine attachment site 6499 6565 1.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00550 Phosphopantetheine attachment site 4936 5002 1.5E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Pfam PF00550 Phosphopantetheine attachment site 8061 8126 5.5E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.50.720 2841 3055 3.5E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 1091 1291 3.42E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF53901 3216 3590 4.39E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 301 317 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 3751 3872 4.71E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 3931 4039 4.71E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00825 Beta-ketoacyl synthase 3220 3646 8.7E-233 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00825 Beta-ketoacyl synthase 5032 5458 5.0E-231 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00825 Beta-ketoacyl synthase 140 566 2.8E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00825 Beta-ketoacyl synthase 1691 2117 2.1E-231 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00825 Beta-ketoacyl synthase 6594 7020 4.3E-232 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.50.720 4647 4830 5.0E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.50.720 1308 1523 2.0E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.50.720 7767 7951 1.0E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF53901 6589 6965 1.27E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00823 Phosphopantetheine attachment site 43 115 1.2E-26 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00823 Phosphopantetheine attachment site 8059 8131 2.9E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00823 Phosphopantetheine attachment site 4934 5006 2.2E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00823 Phosphopantetheine attachment site 6497 6569 1.4E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00823 Phosphopantetheine attachment site 1596 1668 9.1E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00823 Phosphopantetheine attachment site 3125 3197 3.9E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 5564 5685 4.97E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 5744 5847 4.97E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 2624 2824 5.12E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 2215 2340 2.5E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 867 980 1.3E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 7122 7246 4.1E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 3747 3872 1.5E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 5562 5685 3.3E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 667 798 1.3E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 5751 5865 3.3E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 3938 4050 1.5E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 7312 7430 4.1E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.366.10 2406 2518 2.5E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3152 3167 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF51735 7538 7753 1.84E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF47336 1593 1704 1.14E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF47336 6494 6607 4.45E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 Gene3D G3DSA:3.40.50.720 6215 6406 1.3E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF55048 2345 2406 3.66E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 2219 2340 4.19E-78 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF52151 2399 2514 4.19E-78 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 676 976 1.1E-131 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5567 5861 1.0E-127 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3754 4046 2.5E-127 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 7128 7425 2.0E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2222 2514 1.2E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22180 191352b7fb8f03b65bf0596dfb1fec86 8215 SUPERFAMILY SSF53901 135 510 4.33E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS21670 cce1dbb19b305afb0cf53b9c8e3095ae 484 Pfam PF00905 Penicillin binding protein transpeptidase domain 153 478 1.1E-67 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS21670 cce1dbb19b305afb0cf53b9c8e3095ae 484 SUPERFAMILY SSF56601 136 482 3.76E-85 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS21670 cce1dbb19b305afb0cf53b9c8e3095ae 484 Gene3D G3DSA:3.90.1310.10 73 140 6.5E-5 T 17-03-2017 SHXM_RS21670 cce1dbb19b305afb0cf53b9c8e3095ae 484 Gene3D G3DSA:3.40.710.10 141 482 3.8E-92 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS14930 cdb9ba8fb627d1360e5125f2706b568f 289 Gene3D G3DSA:1.10.3720.10 65 264 6.9E-38 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14930 cdb9ba8fb627d1360e5125f2706b568f 289 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 65 155 2.2E-17 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS14930 cdb9ba8fb627d1360e5125f2706b568f 289 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 87 264 2.7E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14930 cdb9ba8fb627d1360e5125f2706b568f 289 SUPERFAMILY SSF161098 64 252 7.06E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26340 4307df8716c20d647a9983fb74d78ade 311 SUPERFAMILY SSF48179 182 281 2.21E-23 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS26340 4307df8716c20d647a9983fb74d78ade 311 Pfam PF10728 Domain of unknown function (DUF2520) 149 274 2.1E-37 T 17-03-2017 IPR018931 Domain of unknown function DUF2520 SHXM_RS26340 4307df8716c20d647a9983fb74d78ade 311 Pfam PF10727 Rossmann-like domain 8 132 3.0E-42 T 17-03-2017 IPR019665 Putative oxidoreductase/dehydrogenase, Rossmann-like domain SHXM_RS26340 4307df8716c20d647a9983fb74d78ade 311 Gene3D G3DSA:1.10.1040.20 182 279 2.0E-30 T 17-03-2017 IPR018931 Domain of unknown function DUF2520 SHXM_RS26340 4307df8716c20d647a9983fb74d78ade 311 SUPERFAMILY SSF51735 18 180 7.48E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS26340 4307df8716c20d647a9983fb74d78ade 311 Gene3D G3DSA:3.40.50.720 16 179 1.9E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SMART SM00331 477 690 5.1E-31 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Gene3D G3DSA:3.30.450.40 4 143 5.7E-9 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SMART SM00065 3 150 0.64 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SMART SM00065 312 459 0.002 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Gene3D G3DSA:3.30.450.40 296 461 9.9E-19 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 508 689 4.2E-47 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SUPERFAMILY SSF81606 494 688 1.33E-5 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Gene3D G3DSA:3.30.450.20 177 242 4.4E-12 T 17-03-2017 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SUPERFAMILY SSF55785 177 256 5.93E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Pfam PF08448 PAS fold 179 265 1.1E-8 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SUPERFAMILY SSF55781 4 144 9.38E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SUPERFAMILY SSF55781 313 462 8.07E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Pfam PF13185 GAF domain 312 450 3.9E-16 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 Pfam PF13185 GAF domain 8 139 1.9E-7 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS44125 d097a04ea00ec5386dc02b1a0ed98d34 695 SMART SM00091 172 238 8.2E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 336 359 7.1E-39 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 360 374 7.1E-39 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 317 334 7.1E-39 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 235 249 7.1E-39 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 296 316 7.1E-39 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 Gene3D G3DSA:3.30.300.50 129 200 3.6E-17 T 17-03-2017 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 345 356 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 SUPERFAMILY SSF50494 219 389 2.01E-32 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 Gene3D G3DSA:2.40.10.10 293 382 1.4E-28 T 17-03-2017 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 Pfam PF02983 Alpha-lytic protease prodomain 130 189 5.9E-10 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 Gene3D G3DSA:2.40.10.10 214 292 1.2E-25 T 17-03-2017 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 Gene3D G3DSA:3.30.300.50 48 128 2.6E-27 T 17-03-2017 SHXM_RS07825 615244d8dcb6340bc1ada81cf4d23aeb 397 PIRSF PIRSF001134 13 397 6.8E-121 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS41145 2b1ca4ee5976551183436ccc01e5b6f6 191 SUPERFAMILY SSF46689 7 81 2.08E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41145 2b1ca4ee5976551183436ccc01e5b6f6 191 Gene3D G3DSA:1.10.357.10 65 189 1.9E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41145 2b1ca4ee5976551183436ccc01e5b6f6 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 1.6E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41145 2b1ca4ee5976551183436ccc01e5b6f6 191 SUPERFAMILY SSF48498 87 182 1.56E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41145 2b1ca4ee5976551183436ccc01e5b6f6 191 Gene3D G3DSA:1.10.10.60 5 64 7.0E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41145 2b1ca4ee5976551183436ccc01e5b6f6 191 Pfam PF13305 WHG domain 91 171 3.5E-13 T 17-03-2017 IPR025996 WHG domain SHXM_RS31650 de6274385ffd9c83a9b6864945135090 308 Gene3D G3DSA:3.50.30.50 90 307 4.8E-31 T 17-03-2017 SHXM_RS31650 de6274385ffd9c83a9b6864945135090 308 Pfam PF04199 Putative cyclase 86 239 6.8E-24 T 17-03-2017 IPR007325 Kynurenine formamidase GO:0004061|GO:0019441 KEGG: 00380+3.5.1.9|KEGG: 00630+3.5.1.9|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-7717|MetaCyc: PWY-7733|MetaCyc: PWY-7734 SHXM_RS31650 de6274385ffd9c83a9b6864945135090 308 SUPERFAMILY SSF102198 87 307 1.31E-24 T 17-03-2017 SHXM_RS29605 fa3950f013529f021bfab80352825fcd 61 Pfam PF05122 Mobile element transfer protein 10 59 7.1E-30 T 17-03-2017 IPR007806 Mobile element transfer SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 Pfam PF00196 Bacterial regulatory proteins, luxR family 97 152 6.7E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 SUPERFAMILY SSF46894 89 157 2.55E-19 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 SMART SM00421 95 152 8.4E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 Gene3D G3DSA:1.10.10.10 91 156 2.6E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 128 140 1.9E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 98 112 1.9E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 112 128 1.9E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44110 ba2f786c24cf3cfabb1298c8cc696576 163 ProSitePatterns PS00622 LuxR-type HTH domain signature. 112 139 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16300 1655015debb953fdb8adac396977a7b9 551 Pfam PF00890 FAD binding domain 6 532 4.2E-111 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS16300 1655015debb953fdb8adac396977a7b9 551 Gene3D G3DSA:3.50.50.60 484 548 2.4E-62 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16300 1655015debb953fdb8adac396977a7b9 551 Gene3D G3DSA:3.50.50.60 3 274 2.4E-62 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16300 1655015debb953fdb8adac396977a7b9 551 PIRSF PIRSF036654 1 550 1.2E-295 T 17-03-2017 IPR014614 Uncharacterised conserved protein UCP036654 GO:0016627|GO:0055114 SHXM_RS16300 1655015debb953fdb8adac396977a7b9 551 SUPERFAMILY SSF51905 3 279 2.68E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16300 1655015debb953fdb8adac396977a7b9 551 SUPERFAMILY SSF51905 487 549 2.68E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 SUPERFAMILY SSF101898 243 423 5.49E-12 T 17-03-2017 SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 SUPERFAMILY SSF101898 494 561 5.49E-12 T 17-03-2017 SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 SMART SM00758 51 191 2.0E-28 T 17-03-2017 IPR011658 PA14 domain SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Gene3D G3DSA:2.60.120.260 683 813 9.6E-28 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 SUPERFAMILY SSF49785 683 810 5.35E-24 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Pfam PF06439 Domain of Unknown Function (DUF1080) 818 1005 2.9E-32 T 17-03-2017 IPR010496 Domain of unknown function DUF1080 SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Pfam PF16990 Carbohydrate binding module (family 35) 684 811 5.6E-11 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Gene3D G3DSA:2.120.10.30 244 423 1.0E-9 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Gene3D G3DSA:2.120.10.30 494 539 1.0E-9 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 SUPERFAMILY SSF56988 98 216 3.66E-12 T 17-03-2017 SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Gene3D G3DSA:3.90.182.10 98 221 1.4E-25 T 17-03-2017 IPR011658 PA14 domain SHXM_RS40550 2143571545ceb63ff511cf618cae8b8f 1008 Pfam PF07691 PA14 domain 52 185 1.9E-19 T 17-03-2017 IPR011658 PA14 domain SHXM_RS13700 a6e007c045759e146e09959b369f3cf2 285 Pfam PF00005 ABC transporter 27 189 3.1E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS13700 a6e007c045759e146e09959b369f3cf2 285 ProSitePatterns PS00211 ABC transporters family signature. 162 176 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS13700 a6e007c045759e146e09959b369f3cf2 285 SUPERFAMILY SSF52540 4 253 1.02E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13700 a6e007c045759e146e09959b369f3cf2 285 Gene3D G3DSA:3.40.50.300 2 265 8.3E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13700 a6e007c045759e146e09959b369f3cf2 285 SMART SM00382 35 239 2.4E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS13700 a6e007c045759e146e09959b369f3cf2 285 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 241 268 4.8E-6 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 SUPERFAMILY SSF52540 349 563 3.42E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 Pfam PF00664 ABC transporter transmembrane region 43 295 1.0E-13 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 Gene3D G3DSA:1.20.1560.10 17 324 1.2E-34 T 17-03-2017 SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 Pfam PF00005 ABC transporter 351 496 1.0E-8 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 ProSitePatterns PS00211 ABC transporters family signature. 469 483 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 SUPERFAMILY SSF90123 16 323 6.02E-39 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS46750 86f6da2fc1df030f8f08b16a4d26523a 566 Gene3D G3DSA:3.40.50.300 347 560 6.9E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Pfam PF02772 S-adenosylmethionine synthetase, central domain 124 248 3.1E-44 T 17-03-2017 IPR022629 S-adenosylmethionine synthetase, central domain GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 TIGRFAM TIGR01034 metK: methionine adenosyltransferase 5 399 1.1E-169 T 17-03-2017 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Gene3D G3DSA:3.30.300.10 261 400 9.4E-70 T 17-03-2017 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Gene3D G3DSA:3.30.300.10 146 250 6.6E-38 T 17-03-2017 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 SUPERFAMILY SSF55973 3 109 4.71E-44 T 17-03-2017 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Hamap MF_00086 S-adenosylmethionine synthase [metK]. 2 400 56.819 T 17-03-2017 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Pfam PF00438 S-adenosylmethionine synthetase, N-terminal domain 4 101 9.2E-40 T 17-03-2017 IPR022628 S-adenosylmethionine synthetase, N-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 ProSitePatterns PS00376 S-adenosylmethionine synthase signature 1. 126 136 - T 17-03-2017 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Pfam PF02773 S-adenosylmethionine synthetase, C-terminal domain 250 389 4.3E-68 T 17-03-2017 IPR022630 S-adenosylmethionine synthetase, C-terminal GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 SUPERFAMILY SSF55973 120 248 7.06E-45 T 17-03-2017 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 SUPERFAMILY SSF55973 250 400 1.69E-67 T 17-03-2017 IPR022636 S-adenosylmethionine synthetase superfamily GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 Gene3D G3DSA:3.30.300.10 11 145 1.5E-44 T 17-03-2017 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 ProSitePatterns PS00377 S-adenosylmethionine synthase signature 2. 276 284 - T 17-03-2017 IPR022631 S-adenosylmethionine synthetase, conserved site GO:0004478|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS12320 600e075fc18c28630fb4d6bcc91efd97 402 PIRSF PIRSF000497 1 401 1.9E-163 T 17-03-2017 IPR002133 S-adenosylmethionine synthetase GO:0004478|GO:0005524|GO:0006556 KEGG: 00270+2.5.1.6|MetaCyc: PWY-5041|MetaCyc: PWY-5912|Reactome: R-HSA-156581 SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 Gene3D G3DSA:3.10.450.50 176 246 2.3E-7 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 SUPERFAMILY SSF54427 177 289 1.13E-9 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 Gene3D G3DSA:1.10.1740.10 7 100 1.8E-14 T 17-03-2017 SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 SUPERFAMILY SSF88659 103 163 6.17E-9 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 SUPERFAMILY SSF88946 8 90 1.73E-14 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 Gene3D G3DSA:1.10.10.10 106 164 4.0E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 8 163 3.0E-16 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 Pfam PF08281 Sigma-70, region 4 110 161 1.9E-6 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00770 eb26650f1448eeb089dc3f180c1b873c 300 Pfam PF04542 Sigma-70 region 2 11 75 3.1E-14 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 TIGRFAM TIGR03356 BGL: beta-galactosidase 21 450 2.3E-187 T 17-03-2017 IPR017736 Glycoside hydrolase, family 1, beta-glucosidase GO:0008422|GO:0030245 KEGG: 00460+3.2.1.21|KEGG: 00500+3.2.1.21|KEGG: 00940+3.2.1.21|MetaCyc: PWY-3121|MetaCyc: PWY-5176|MetaCyc: PWY-6002|MetaCyc: PWY-6788|MetaCyc: PWY-7089|MetaCyc: PWY-7091|MetaCyc: PWY-7092 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 25 39 - T 17-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 Pfam PF00232 Glycosyl hydrolase family 1 20 457 1.3E-153 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 PRINTS PR00131 Glycosyl hydrolase family 1 signature 362 370 4.3E-21 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 PRINTS PR00131 Glycosyl hydrolase family 1 signature 383 394 4.3E-21 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 PRINTS PR00131 Glycosyl hydrolase family 1 signature 404 421 4.3E-21 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 PRINTS PR00131 Glycosyl hydrolase family 1 signature 299 313 4.3E-21 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 PRINTS PR00131 Glycosyl hydrolase family 1 signature 428 440 4.3E-21 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 SUPERFAMILY SSF51445 20 458 1.52E-159 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06895 925ba3ba73fd307dd77200b3e94983c8 465 Gene3D G3DSA:3.20.20.80 20 458 3.1E-156 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 Gene3D G3DSA:2.130.10.10 761 930 9.2E-24 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 Gene3D G3DSA:2.130.10.10 518 738 1.3E-13 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SUPERFAMILY SSF52200 13 105 9.94E-10 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 Gene3D G3DSA:2.130.10.10 280 442 9.9E-19 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SUPERFAMILY SSF50978 764 917 1.77E-38 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SUPERFAMILY SSF50978 292 431 1.77E-38 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 Pfam PF08937 MTH538 TIR-like domain (DUF1863) 18 115 7.9E-9 T 17-03-2017 IPR015032 MTH538 TIR-like domain SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 Pfam PF13360 PQQ-like domain 774 915 8.3E-9 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 Gene3D G3DSA:3.40.50.10140 15 102 1.1E-7 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 851 865 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 785 824 5.9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 368 407 1.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 876 917 2.4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 287 325 7.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 331 366 7.9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 827 864 0.65 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 552 590 87.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SMART SM00320 411 449 360.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00405 6f1e2b8e4c81ff1b3f7cbbc588864708 959 SUPERFAMILY SSF75011 558 830 1.02E-20 T 17-03-2017 SHXM_RS17545 627cbcd59713f0544f85a4c416cd1897 278 Pfam PF01903 CbiX 144 246 4.9E-19 T 17-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 SHXM_RS17545 627cbcd59713f0544f85a4c416cd1897 278 Pfam PF01903 CbiX 13 116 9.9E-13 T 17-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 SHXM_RS17545 627cbcd59713f0544f85a4c416cd1897 278 Gene3D G3DSA:3.40.50.1400 6 125 5.1E-18 T 17-03-2017 SHXM_RS17545 627cbcd59713f0544f85a4c416cd1897 278 Gene3D G3DSA:3.40.50.1400 135 254 7.1E-25 T 17-03-2017 SHXM_RS17545 627cbcd59713f0544f85a4c416cd1897 278 SUPERFAMILY SSF53800 5 253 1.2E-41 T 17-03-2017 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 Gene3D G3DSA:3.40.50.720 5 167 8.3E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 169 287 7.3E-40 T 17-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 ProSitePatterns PS00895 3-hydroxyisobutyrate dehydrogenase signature. 10 23 - T 17-03-2017 IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 SUPERFAMILY SSF48179 167 295 6.8E-38 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 TIGRFAM TIGR01505 tartro_sem_red: 2-hydroxy-3-oxopropionate reductase 7 294 1.1E-123 T 17-03-2017 IPR006398 2-hydroxy-3-oxopropionate reductase GO:0008679|GO:0046487|GO:0055114 KEGG: 00630+1.1.1.60 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 7 166 2.0E-51 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 PIRSF PIRSF000103 1 298 2.8E-83 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 SUPERFAMILY SSF51735 6 167 4.7E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40905 6ff9d5dc00e965fd3a37abf3195212e3 298 Gene3D G3DSA:1.10.1040.10 169 294 1.3E-41 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 Gene3D G3DSA:2.60.40.420 204 313 6.4E-21 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 Pfam PF07732 Multicopper oxidase 82 190 2.2E-11 T 17-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 SUPERFAMILY SSF49503 204 318 1.13E-22 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 ProSitePatterns PS00080 Multicopper oxidases signature 2. 296 307 - T 17-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 SUPERFAMILY SSF49503 79 210 8.82E-18 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 Pfam PF07731 Multicopper oxidase 209 315 5.0E-15 T 17-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 SHXM_RS07820 b3719bc84ca1d756c5e9533dbf984526 334 Gene3D G3DSA:2.60.40.420 49 188 1.2E-22 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 Pfam PF00494 Squalene/phytoene synthase 34 258 8.6E-36 T 17-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 Gene3D G3DSA:1.10.600.10 16 285 7.5E-28 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 Gene3D G3DSA:3.40.1180.10 288 523 2.3E-88 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 Pfam PF01255 Putative undecaprenyl diphosphate synthase 302 522 5.8E-71 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 295 522 9.1E-66 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 SUPERFAMILY SSF48576 17 288 4.03E-40 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 SUPERFAMILY SSF64005 292 517 1.18E-77 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 295 523 35.497 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS11725 a3651202d16d429265c6b9ed88800f4f 538 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 468 485 - T 17-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 SHXM_RS15585 9c762f5228791d00ae5cf6de450925c7 339 Gene3D G3DSA:3.40.50.720 24 143 3.2E-14 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15585 9c762f5228791d00ae5cf6de450925c7 339 SUPERFAMILY SSF55347 152 284 2.13E-16 T 17-03-2017 SHXM_RS15585 9c762f5228791d00ae5cf6de450925c7 339 Gene3D G3DSA:3.30.360.10 152 327 7.1E-20 T 17-03-2017 SHXM_RS15585 9c762f5228791d00ae5cf6de450925c7 339 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 30 127 1.5E-9 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS15585 9c762f5228791d00ae5cf6de450925c7 339 SUPERFAMILY SSF51735 23 156 4.55E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15585 9c762f5228791d00ae5cf6de450925c7 339 SUPERFAMILY SSF51735 185 198 4.55E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 13 188 5.11E-32 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF56801 3139 3759 2.62E-137 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF47336 1076 1144 4.58E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF13193 AMP-binding enzyme C-terminal domain 3630 3721 1.1E-9 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF13193 AMP-binding enzyme C-terminal domain 2506 2593 4.8E-12 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF47336 2612 2684 8.64E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 1162 1334 1.89E-26 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 1811 2055 2.33E-53 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF13745 HxxPF-repeated domain 3030 3125 2.5E-25 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2643 2658 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1104 1119 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2231 2242 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 2237 2409 4.4E-42 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 ProSitePatterns PS00455 Putative AMP-binding domain signature. 663 674 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF47336 3739 3812 1.57E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF56801 453 602 6.54E-134 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF56801 632 971 6.54E-134 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF56801 1015 1092 6.54E-134 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF56801 2078 2632 9.03E-150 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00550 Phosphopantetheine attachment site 2621 2681 6.1E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00550 Phosphopantetheine attachment site 1082 1144 2.7E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00550 Phosphopantetheine attachment site 3747 3811 9.4E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 2897 3143 3.0E-57 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3770 3785 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 1629 1825 3.56E-41 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 464 578 1.5E-38 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 648 686 1.5E-38 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 3355 3391 5.1E-34 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 3191 3302 5.1E-34 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3217 3645 1.4E-114 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2109 2522 1.1E-129 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SMART SM00823 Phosphopantetheine attachment site 2619 2688 8.3E-9 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SMART SM00823 Phosphopantetheine attachment site 1080 1148 4.8E-10 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SMART SM00823 Phosphopantetheine attachment site 3746 3815 2.9E-8 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00501 AMP-binding enzyme 469 917 5.3E-90 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00501 AMP-binding enzyme 2088 2498 2.1E-95 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00501 AMP-binding enzyme 3195 3622 5.9E-81 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 2715 2893 9.89E-49 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 2082 2236 1.3E-43 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.1820 3822 3936 5.5E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.1820 4022 4087 5.5E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00975 Thioesterase domain 3833 4076 3.6E-23 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SMART SM00824 Thioesterase 3835 4089 0.004 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1475 1602 3.4E-26 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:2.30.38.10 3534 3611 5.8E-26 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:2.30.38.10 2410 2488 2.4E-23 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:2.30.38.10 829 907 1.9E-25 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 1348 1602 4.34E-31 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.30.300.30 3617 3750 1.8E-35 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.30.300.30 2493 2623 5.5E-37 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF52777 194 435 1.11E-38 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.30.300.30 1011 1063 2.7E-33 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.30.300.30 911 961 2.7E-33 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 SUPERFAMILY SSF53474 3812 4085 5.3E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:1.10.1200.10 2624 2689 2.0E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:1.10.1200.10 3751 3813 1.0E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:1.10.1200.10 1076 1147 1.8E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 3392 3533 8.3E-36 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Gene3D G3DSA:3.40.50.980 689 828 5.4E-33 T 17-03-2017 SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00668 Condensation domain 2712 3008 8.1E-62 T 17-03-2017 IPR001242 Condensation domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00668 Condensation domain 1180 1463 1.2E-29 T 17-03-2017 IPR001242 Condensation domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00668 Condensation domain 8 304 1.5E-43 T 17-03-2017 IPR001242 Condensation domain SHXM_RS10835 35e3edc2cae79dc98d3596e8d0b8c2ca 4122 Pfam PF00668 Condensation domain 1663 1923 3.9E-50 T 17-03-2017 IPR001242 Condensation domain SHXM_RS41645 89ac75b76f788bf6eb376dd3426ab92e 217 Gene3D G3DSA:3.40.50.150 10 148 2.0E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS41645 89ac75b76f788bf6eb376dd3426ab92e 217 SUPERFAMILY SSF53335 12 196 2.74E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS41645 89ac75b76f788bf6eb376dd3426ab92e 217 Pfam PF13649 Methyltransferase domain 47 138 8.8E-17 T 17-03-2017 SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 Gene3D G3DSA:3.30.450.40 78 238 1.6E-22 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 SUPERFAMILY SSF46785 11 76 3.12E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 Gene3D G3DSA:1.10.10.10 9 70 4.0E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 SMART SM00346 11 97 1.7E-6 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 SUPERFAMILY SSF55781 78 238 3.47E-21 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 Pfam PF01614 Bacterial transcriptional regulator 132 234 2.8E-6 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS37725 b42ef85acfb63181487ef1a5de6b79fb 264 Pfam PF09339 IclR helix-turn-helix domain 14 61 4.9E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 Gene3D G3DSA:3.40.50.1820 333 444 2.2E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 Gene3D G3DSA:3.40.50.1820 29 261 2.2E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 SUPERFAMILY SSF53474 29 274 3.08E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 Pfam PF00561 alpha/beta hydrolase fold 65 217 2.3E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 97 108 4.5E-9 T 17-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 156 170 4.5E-9 T 17-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 SHXM_RS25465 5866f7bf16751c83d1f56ea4de301ac6 452 PRINTS PR00793 Prolyl aminopeptidase (S33) family signature 67 75 4.5E-9 T 17-03-2017 IPR002410 Peptidase S33 GO:0006508|GO:0008233 KEGG: 00330+3.4.11.5 SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 Pfam PF13602 Zinc-binding dehydrogenase 193 318 3.1E-26 T 17-03-2017 SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 SUPERFAMILY SSF50129 5 155 1.13E-40 T 17-03-2017 IPR011032 GroES-like SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 Gene3D G3DSA:3.90.180.10 5 156 9.4E-51 T 17-03-2017 IPR011032 GroES-like SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 SUPERFAMILY SSF51735 123 250 3.23E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 Gene3D G3DSA:3.40.50.720 157 245 6.4E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 151 172 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 SMART SM00829 15 318 2.5E-25 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS05480 ab98122bdb17eecc5c2baf650612b6a5 322 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 32 99 1.2E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS18315 32cad9d9e4fdee8da6f02e5773f02b89 269 SUPERFAMILY SSF51366 12 257 1.65E-77 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS18315 32cad9d9e4fdee8da6f02e5773f02b89 269 Hamap MF_00134_B Indole-3-glycerol phosphate synthase [trpC]. 2 257 33.669 T 17-03-2017 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 SHXM_RS18315 32cad9d9e4fdee8da6f02e5773f02b89 269 ProSitePatterns PS00614 Indole-3-glycerol phosphate synthase signature. 51 68 - T 17-03-2017 IPR001468 Indole-3-glycerol phosphate synthase, conserved site GO:0004425|GO:0006568 KEGG: 00400+4.1.1.48 SHXM_RS18315 32cad9d9e4fdee8da6f02e5773f02b89 269 Pfam PF00218 Indole-3-glycerol phosphate synthase 4 255 7.3E-80 T 17-03-2017 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 SHXM_RS18315 32cad9d9e4fdee8da6f02e5773f02b89 269 Gene3D G3DSA:3.20.20.70 2 259 5.4E-94 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18315 32cad9d9e4fdee8da6f02e5773f02b89 269 Hamap MF_00134_A Indole-3-glycerol phosphate synthase [trpC]. 34 253 29.38 T 17-03-2017 IPR013798 Indole-3-glycerol phosphate synthase GO:0004425 KEGG: 00400+4.1.1.48 SHXM_RS03205 9c149961bc943d7cc6185c5d289f6978 371 Pfam PF09587 Bacterial capsule synthesis protein PGA_cap 7 288 1.7E-73 T 17-03-2017 IPR019079 Capsule synthesis protein, CapA SHXM_RS03205 9c149961bc943d7cc6185c5d289f6978 371 SUPERFAMILY SSF56300 58 297 1.52E-31 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS03205 9c149961bc943d7cc6185c5d289f6978 371 SUPERFAMILY SSF56300 9 17 1.52E-31 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS03205 9c149961bc943d7cc6185c5d289f6978 371 Gene3D G3DSA:3.60.21.30 73 294 6.4E-10 T 17-03-2017 SHXM_RS03205 9c149961bc943d7cc6185c5d289f6978 371 SMART SM00854 7 288 4.1E-104 T 17-03-2017 IPR019079 Capsule synthesis protein, CapA SHXM_RS02525 ee4a18cd1ecf31830e6fd036a1472e93 275 Gene3D G3DSA:3.40.50.150 13 150 4.3E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02525 ee4a18cd1ecf31830e6fd036a1472e93 275 SUPERFAMILY SSF53335 15 226 1.79E-35 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02525 ee4a18cd1ecf31830e6fd036a1472e93 275 SMART SM00650 36 165 0.0054 T 17-03-2017 IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal GO:0000154|GO:0000179|GO:0008649 SHXM_RS02525 ee4a18cd1ecf31830e6fd036a1472e93 275 Pfam PF08241 Methyltransferase domain 53 146 4.3E-19 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 Gene3D G3DSA:2.30.38.10 408 468 4.6E-19 T 17-03-2017 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 Gene3D G3DSA:3.40.50.980 345 407 6.0E-29 T 17-03-2017 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 Gene3D G3DSA:3.40.50.980 191 289 6.0E-29 T 17-03-2017 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 Gene3D G3DSA:3.40.50.980 20 190 3.4E-34 T 17-03-2017 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 Gene3D G3DSA:3.30.300.30 475 597 2.5E-6 T 17-03-2017 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 ProSitePatterns PS00455 Putative AMP-binding domain signature. 184 195 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 Pfam PF00501 AMP-binding enzyme 24 477 3.3E-96 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 SUPERFAMILY SSF56801 348 606 1.19E-115 T 17-03-2017 SHXM_RS14305 4e461150612f44057a6c93a39384b7fa 608 SUPERFAMILY SSF56801 18 294 1.19E-115 T 17-03-2017 SHXM_RS36770 ffc8a94d3af35c2f43ec5a900b2a86fb 506 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 258 265 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS36770 ffc8a94d3af35c2f43ec5a900b2a86fb 506 Gene3D G3DSA:3.40.309.10 274 464 2.8E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS36770 ffc8a94d3af35c2f43ec5a900b2a86fb 506 Gene3D G3DSA:3.40.605.10 17 273 6.0E-96 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36770 ffc8a94d3af35c2f43ec5a900b2a86fb 506 Pfam PF00171 Aldehyde dehydrogenase family 28 484 9.2E-171 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36770 ffc8a94d3af35c2f43ec5a900b2a86fb 506 SUPERFAMILY SSF53720 15 487 1.27E-161 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS36770 ffc8a94d3af35c2f43ec5a900b2a86fb 506 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 286 297 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS20290 11fb638af67d2045998820759c6c2fa4 271 Pfam PF00144 Beta-lactamase 12 262 1.5E-40 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS20290 11fb638af67d2045998820759c6c2fa4 271 Gene3D G3DSA:3.40.710.10 6 266 6.6E-48 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS20290 11fb638af67d2045998820759c6c2fa4 271 SUPERFAMILY SSF56601 6 265 1.69E-55 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 SUPERFAMILY SSF46785 12 77 4.05E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 SUPERFAMILY SSF54909 250 329 1.74E-9 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 Pfam PF01037 Lrp/AsnC ligand binding domain 260 326 6.1E-9 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 SUPERFAMILY SSF46785 191 241 5.0E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 Gene3D G3DSA:3.30.70.920 76 148 4.0E-7 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 Gene3D G3DSA:3.30.70.920 254 329 7.9E-11 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 Gene3D G3DSA:1.10.10.10 16 59 1.2E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 Gene3D G3DSA:1.10.10.10 195 237 1.2E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 Pfam PF13404 AsnC-type helix-turn-helix domain 16 52 6.3E-11 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 SMART SM00344 16 116 3.8E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS44120 6d00209f0eaa3256a40fbf7c271b0798 350 SMART SM00344 195 296 7.9E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS40545 d1c7d9a4aa266dc039a04fc48b398531 213 Pfam PF03737 Demethylmenaquinone methyltransferase 40 174 5.0E-32 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS40545 d1c7d9a4aa266dc039a04fc48b398531 213 SUPERFAMILY SSF89562 24 180 6.67E-40 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS40545 d1c7d9a4aa266dc039a04fc48b398531 213 Gene3D G3DSA:3.50.30.40 34 182 8.1E-42 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS05470 3ab8a8dd65c419d658f0c43ccd547943 451 Gene3D G3DSA:1.20.1250.20 25 224 8.6E-42 T 17-03-2017 SHXM_RS05470 3ab8a8dd65c419d658f0c43ccd547943 451 Pfam PF07690 Major Facilitator Superfamily 34 395 2.2E-43 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS05470 3ab8a8dd65c419d658f0c43ccd547943 451 SUPERFAMILY SSF103473 7 431 1.44E-80 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05470 3ab8a8dd65c419d658f0c43ccd547943 451 Gene3D G3DSA:1.20.1250.20 246 433 2.9E-24 T 17-03-2017 SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 Gene3D G3DSA:1.20.1250.20 21 200 9.4E-28 T 17-03-2017 SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 Gene3D G3DSA:1.20.1250.20 273 428 1.6E-16 T 17-03-2017 SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 Gene3D G3DSA:1.20.1250.20 482 506 1.6E-16 T 17-03-2017 SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 Pfam PF07690 Major Facilitator Superfamily 29 418 3.3E-43 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 SUPERFAMILY SSF103473 481 507 1.44E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 SUPERFAMILY SSF103473 13 205 1.44E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36205 c69251e78bfd2593742e895cbeb94e51 554 SUPERFAMILY SSF103473 256 427 1.44E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 ProSitePatterns PS00519 AsnC-type HTH domain signature. 21 47 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 SUPERFAMILY SSF54909 64 144 4.29E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 30 49 2.3E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 19 30 2.3E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 3 19 2.3E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 Gene3D G3DSA:3.30.70.920 56 145 3.8E-16 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 SUPERFAMILY SSF46785 2 62 2.11E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 Pfam PF01037 Lrp/AsnC ligand binding domain 70 142 1.6E-11 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 Gene3D G3DSA:1.10.10.10 2 54 9.1E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 Pfam PF13412 Winged helix-turn-helix DNA-binding 3 49 3.9E-15 T 17-03-2017 SHXM_RS06760 cf2f707a54e94bbd3636a9b62e1e6922 164 SMART SM00344 3 112 6.5E-32 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 SUPERFAMILY SSF52467 190 371 1.44E-40 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 Gene3D G3DSA:3.40.50.970 392 620 5.1E-56 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 Gene3D G3DSA:3.40.50.970 6 214 1.0E-59 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 SUPERFAMILY SSF52518 400 616 7.37E-48 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 223 357 7.3E-32 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 10 203 6.0E-34 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 421 579 1.5E-39 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 TIGRFAM TIGR04377 myo_inos_iolD: 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase 8 625 2.8E-272 T 17-03-2017 IPR030817 3,5/4-trihydroxycyclohexa-1,2-dione hydrolase GO:0016823|GO:0019310|GO:0030976 KEGG: 00562+3.7.1.22 SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 SUPERFAMILY SSF52518 8 214 9.95E-30 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS22245 117dde4a1a84438467dab0c3e5bc2c57 628 Gene3D G3DSA:3.40.50.1220 215 369 3.3E-40 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14135 b623ad0ad5ce55022524de0e86f94d88 463 Pfam PF07690 Major Facilitator Superfamily 47 358 2.3E-26 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS14135 b623ad0ad5ce55022524de0e86f94d88 463 Gene3D G3DSA:1.20.1250.20 40 226 3.9E-16 T 17-03-2017 SHXM_RS14135 b623ad0ad5ce55022524de0e86f94d88 463 SUPERFAMILY SSF103473 28 446 1.57E-52 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14135 b623ad0ad5ce55022524de0e86f94d88 463 Gene3D G3DSA:1.20.1250.20 266 447 8.1E-23 T 17-03-2017 SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 SUPERFAMILY SSF48179 522 615 1.87E-17 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 340 520 1.6E-58 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 Gene3D G3DSA:3.90.226.10 35 243 4.9E-36 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 Gene3D G3DSA:1.10.1040.10 526 608 4.4E-10 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 Gene3D G3DSA:3.40.50.720 335 525 1.1E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 SUPERFAMILY SSF48179 634 695 2.72E-10 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 SUPERFAMILY SSF52096 253 326 1.57E-34 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 SUPERFAMILY SSF52096 34 220 1.57E-34 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 524 606 1.3E-11 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 SUPERFAMILY SSF51735 337 522 1.94E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38225 6959425cb927b0ae8b4a8d2cf01d127b 709 Pfam PF00378 Enoyl-CoA hydratase/isomerase 54 241 1.9E-19 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS25935 080cad30fdd459cff041427f4060ef96 193 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 59 3.2E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25935 080cad30fdd459cff041427f4060ef96 193 SUPERFAMILY SSF46689 3 79 6.48E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25935 080cad30fdd459cff041427f4060ef96 193 SUPERFAMILY SSF48498 76 185 5.93E-16 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS25935 080cad30fdd459cff041427f4060ef96 193 Gene3D G3DSA:1.10.357.10 8 176 4.3E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS25935 080cad30fdd459cff041427f4060ef96 193 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 13 26 4.7E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25935 080cad30fdd459cff041427f4060ef96 193 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 34 57 4.7E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS21285 b64148e2c4ea1778bfc3b44032a14a5c 363 SUPERFAMILY SSF51412 99 349 3.21E-60 T 17-03-2017 SHXM_RS21285 b64148e2c4ea1778bfc3b44032a14a5c 363 SUPERFAMILY SSF51412 9 72 3.21E-60 T 17-03-2017 SHXM_RS21285 b64148e2c4ea1778bfc3b44032a14a5c 363 Gene3D G3DSA:3.20.20.70 2 336 7.8E-67 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS21285 b64148e2c4ea1778bfc3b44032a14a5c 363 Pfam PF03060 Nitronate monooxygenase 3 344 1.3E-104 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS09425 d43cc06a35d1b5cd5bfa43d0a3993a20 353 Gene3D G3DSA:3.80.10.10 259 329 1.3E-5 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS09425 d43cc06a35d1b5cd5bfa43d0a3993a20 353 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 30 167 1.6E-14 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS09425 d43cc06a35d1b5cd5bfa43d0a3993a20 353 Gene3D G3DSA:3.40.1580.10 31 168 6.9E-5 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS09425 d43cc06a35d1b5cd5bfa43d0a3993a20 353 SMART SM00860 27 169 8.3E-7 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS09425 d43cc06a35d1b5cd5bfa43d0a3993a20 353 SUPERFAMILY SSF160631 27 170 9.16E-10 T 17-03-2017 SHXM_RS01145 35554051e833beb774449e7877b12b53 589 ProSitePatterns PS00455 Putative AMP-binding domain signature. 205 216 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS01145 35554051e833beb774449e7877b12b53 589 Gene3D G3DSA:3.30.300.30 455 555 1.1E-28 T 17-03-2017 SHXM_RS01145 35554051e833beb774449e7877b12b53 589 SUPERFAMILY SSF56801 46 559 2.35E-132 T 17-03-2017 SHXM_RS01145 35554051e833beb774449e7877b12b53 589 Pfam PF13193 AMP-binding enzyme C-terminal domain 470 547 2.0E-21 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS01145 35554051e833beb774449e7877b12b53 589 Gene3D G3DSA:3.40.50.980 211 368 4.7E-26 T 17-03-2017 SHXM_RS01145 35554051e833beb774449e7877b12b53 589 Gene3D G3DSA:3.40.50.980 58 210 2.7E-30 T 17-03-2017 SHXM_RS01145 35554051e833beb774449e7877b12b53 589 Gene3D G3DSA:2.30.38.10 370 450 1.3E-14 T 17-03-2017 SHXM_RS01145 35554051e833beb774449e7877b12b53 589 Pfam PF00501 AMP-binding enzyme 41 460 1.2E-76 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 Pfam PF14310 Fibronectin type III-like domain 700 770 3.9E-15 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 Gene3D G3DSA:3.40.50.1700 396 666 1.3E-62 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 407 663 4.8E-46 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 PRINTS PR00133 Glycosyl hydrolase family 3 signature 101 117 1.7E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 PRINTS PR00133 Glycosyl hydrolase family 3 signature 201 217 1.7E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 PRINTS PR00133 Glycosyl hydrolase family 3 signature 170 186 1.7E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 PRINTS PR00133 Glycosyl hydrolase family 3 signature 272 290 1.7E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 PRINTS PR00133 Glycosyl hydrolase family 3 signature 124 143 1.7E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 SUPERFAMILY SSF52279 515 666 2.35E-46 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 SUPERFAMILY SSF52279 407 486 2.35E-46 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 24 352 3.2E-67 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 SUPERFAMILY SSF51445 3 406 7.69E-94 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 Gene3D G3DSA:3.20.20.300 4 362 5.7E-101 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20765 8310940b52650cbc91b49b31dce820bf 803 SMART SM01217 700 770 9.1E-22 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 SUPERFAMILY SSF47323 774 956 6.17E-30 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Hamap MF_00049_B Leucine--tRNA ligase [leuS]. 18 957 21.397 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Gene3D G3DSA:3.90.740.10 296 521 9.0E-51 T 17-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Pfam PF09334 tRNA synthetases class I (M) 65 167 2.9E-13 T 17-03-2017 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Gene3D G3DSA:1.10.730.10 759 893 1.2E-34 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 68 78 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 TIGRFAM TIGR00396 leuS_bact: leucine--tRNA ligase 219 956 2.8E-218 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Pfam PF13603 Leucyl-tRNA synthetase, Domain 2 293 501 3.7E-60 T 17-03-2017 IPR025709 Leucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 KEGG: 00970+6.1.1.4 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 SUPERFAMILY SSF52374 220 298 1.87E-113 T 17-03-2017 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 SUPERFAMILY SSF52374 513 778 1.87E-113 T 17-03-2017 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 SUPERFAMILY SSF52374 24 172 1.87E-113 T 17-03-2017 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Gene3D G3DSA:3.40.50.620 729 758 2.7E-135 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Gene3D G3DSA:3.40.50.620 219 295 2.7E-135 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Gene3D G3DSA:3.40.50.620 522 696 2.7E-135 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Gene3D G3DSA:3.40.50.620 22 171 2.7E-135 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 Pfam PF08264 Anticodon-binding domain of tRNA 806 918 1.1E-14 T 17-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 SUPERFAMILY SSF50677 295 516 2.41E-43 T 17-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 287 306 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 258 271 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 599 617 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 225 241 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 152 169 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 647 669 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS21515 d1e38be4d390f267e675bfc1f4572032 958 PRINTS PR00985 Leucyl-tRNA synthetase signature 680 690 3.2E-52 T 17-03-2017 IPR002302 Leucine-tRNA ligase GO:0000166|GO:0004823|GO:0005524|GO:0006429 KEGG: 00970+6.1.1.4|Reactome: R-HSA-379726 SHXM_RS43235 f4ab116689b82f0c9d491cf311ad5d8c 244 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 16 129 5.2E-20 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS43235 f4ab116689b82f0c9d491cf311ad5d8c 244 SUPERFAMILY SSF109854 17 132 9.39E-11 T 17-03-2017 SHXM_RS43235 f4ab116689b82f0c9d491cf311ad5d8c 244 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 15 220 2.7E-27 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS43235 f4ab116689b82f0c9d491cf311ad5d8c 244 Pfam PF07398 MDMPI C-terminal domain 143 236 2.3E-14 T 17-03-2017 IPR010872 MDMPI C-terminal SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 TIGRFAM TIGR03551 F420_cofH: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit 502 846 3.2E-162 T 17-03-2017 IPR019940 CofH family GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 536 844 6.6E-108 T 17-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 Pfam PF04055 Radical SAM superfamily 85 267 2.6E-14 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 Pfam PF04055 Radical SAM superfamily 544 717 7.9E-16 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 SMART SM00729 81 318 1.1E-5 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 SMART SM00729 540 765 0.014 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 SUPERFAMILY SSF102114 499 810 1.44E-49 T 17-03-2017 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 Hamap MF_01611 FO synthase subunit 1 [cofG]. 77 408 50.43 T 17-03-2017 IPR019939 CofG family GO:0009108|GO:0016765|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 SUPERFAMILY SSF102114 71 383 7.46E-38 T 17-03-2017 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 Hamap MF_01612 FO synthase subunit 2 [cofH]. 487 847 48.682 T 17-03-2017 IPR019940 CofH family GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 Gene3D G3DSA:3.20.20.70 37 369 6.1E-68 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 Gene3D G3DSA:3.20.20.70 500 833 3.3E-75 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS31880 f4925633476407fe01a6d926471f1598 870 TIGRFAM TIGR03550 F420_cofG: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit 78 406 4.2E-144 T 17-03-2017 IPR019939 CofG family GO:0009108|GO:0016765|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Gene3D G3DSA:2.130.10.10 1 262 1.2E-77 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 54 68 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 209 236 3.2E-6 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 366 398 2.8E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 155 191 4.8E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 285 318 1.5E-7 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 78 108 7.1E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 36 67 8.2E-10 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 326 358 2.6E-10 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 1 26 1.6E-7 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 119 149 1.2E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 408 441 3.5E-7 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Pfam PF00400 WD domain, G-beta repeat 248 277 0.0011 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 136 150 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 305 319 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 PRINTS PR00320 G protein beta WD-40 repeat signature 54 68 2.3E-10 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 PRINTS PR00320 G protein beta WD-40 repeat signature 95 109 2.3E-10 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 PRINTS PR00320 G protein beta WD-40 repeat signature 136 150 2.3E-10 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 Gene3D G3DSA:2.130.10.10 263 483 3.1E-67 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SUPERFAMILY SSF50978 207 477 5.49E-71 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 1 26 2.1 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 279 318 5.8E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 111 149 3.0E-11 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 197 236 1.7E-5 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 361 400 2.4E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 29 67 1.5E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 320 358 1.1E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 445 482 1.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 70 108 5.4E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 239 277 0.0058 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 403 442 3.6E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SMART SM00320 152 191 2.0E-10 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 178 192 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 SUPERFAMILY SSF50978 1 277 5.04E-79 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS11630 7301443a5174034680fb23a7e09d57fb 492 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 95 109 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 SMART SM00354 4 71 8.9E-6 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 SUPERFAMILY SSF47413 4 48 3.46E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 46 1.9E-9 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 Gene3D G3DSA:3.40.50.2300 175 316 2.3E-18 T 17-03-2017 SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 Gene3D G3DSA:3.40.50.2300 106 174 5.5E-11 T 17-03-2017 SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 SUPERFAMILY SSF53822 71 317 1.0E-25 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 Pfam PF13407 Periplasmic binding protein domain 106 294 3.6E-23 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS12205 bbf805f444c2c5e17bc2bc1a3cce01b1 348 Gene3D G3DSA:1.10.260.40 7 46 5.0E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS21545 dfbad02380897b721f4e98b6ae9a7cda 146 SUPERFAMILY SSF81301 7 118 5.07E-35 T 17-03-2017 SHXM_RS21545 dfbad02380897b721f4e98b6ae9a7cda 146 Hamap MF_01477 Ribosomal silencing factor RsfS [rsfS]. 7 110 22.73 T 17-03-2017 IPR004394 Protein Iojap/ribosomal silencing factor RsfS SHXM_RS21545 dfbad02380897b721f4e98b6ae9a7cda 146 Gene3D G3DSA:3.30.460.10 8 113 1.6E-32 T 17-03-2017 SHXM_RS21545 dfbad02380897b721f4e98b6ae9a7cda 146 Pfam PF02410 Ribosomal silencing factor during starvation 14 109 7.9E-22 T 17-03-2017 SHXM_RS21545 dfbad02380897b721f4e98b6ae9a7cda 146 TIGRFAM TIGR00090 rsfS_iojap_ybeB: ribosome silencing factor 11 109 2.5E-29 T 17-03-2017 IPR004394 Protein Iojap/ribosomal silencing factor RsfS SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 Pfam PF07690 Major Facilitator Superfamily 30 425 1.3E-54 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 SUPERFAMILY SSF103473 264 472 5.1E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 SUPERFAMILY SSF103473 1 210 5.1E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 Gene3D G3DSA:1.20.1250.20 25 209 1.2E-24 T 17-03-2017 SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 PRINTS PR01036 Tetracycline resistance protein TetB signature 151 175 3.9E-6 T 17-03-2017 SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 PRINTS PR01036 Tetracycline resistance protein TetB signature 29 53 3.9E-6 T 17-03-2017 SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 PRINTS PR01036 Tetracycline resistance protein TetB signature 416 435 3.9E-6 T 17-03-2017 SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 Gene3D G3DSA:1.20.1250.20 278 468 1.4E-22 T 17-03-2017 SHXM_RS19065 6e84497a89b12b90ea39e07e512b8cb5 482 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 28 434 5.4E-71 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 SUPERFAMILY SSF51971 328 528 9.42E-26 T 17-03-2017 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 PRINTS PR00419 Adrenodoxin reductase family signature 377 399 5.2E-8 T 17-03-2017 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 PRINTS PR00419 Adrenodoxin reductase family signature 401 414 5.2E-8 T 17-03-2017 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 10 324 3.9E-39 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 Gene3D G3DSA:3.20.20.70 10 351 1.4E-78 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 Gene3D G3DSA:3.40.50.720 374 510 3.5E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 Gene3D G3DSA:3.50.50.60 511 601 3.8E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 SUPERFAMILY SSF51395 9 338 1.05E-73 T 17-03-2017 SHXM_RS40940 9626fdf41de54ed203f4b4ec36858784 649 Pfam PF13450 NAD(P)-binding Rossmann-like domain 380 422 3.0E-9 T 17-03-2017 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 ProSitePatterns PS00622 LuxR-type HTH domain signature. 165 192 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 SMART SM00448 9 122 4.9E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 Gene3D G3DSA:3.40.50.2300 8 154 1.2E-40 T 17-03-2017 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 Pfam PF00072 Response regulator receiver domain 11 123 1.2E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 Pfam PF00196 Bacterial regulatory proteins, luxR family 150 205 1.7E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 SUPERFAMILY SSF52172 8 179 6.88E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 Gene3D G3DSA:1.10.10.10 155 210 1.2E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 7.4E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 7.4E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 7.4E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22205 60c475d320ee871d41838004844e0b0b 212 SMART SM00421 148 205 2.0E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00097 Anthranilate synthase component II signature 173 186 5.2E-5 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00097 Anthranilate synthase component II signature 84 95 5.2E-5 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00097 Anthranilate synthase component II signature 57 66 5.2E-5 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Hamap MF_00344 GMP synthase [glutamine-hydrolyzing] [guaA]. 10 528 53.733 T 17-03-2017 IPR022955 GMP synthase GO:0003922|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Pfam PF00117 Glutamine amidotransferase class-I 15 195 6.1E-41 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Pfam PF02540 NAD synthase 214 289 1.1E-7 T 17-03-2017 IPR022310 NAD/GMP synthase SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 TIGRFAM TIGR00888 guaA_Nterm: GMP synthase (glutamine-hydrolyzing), N-terminal domain 13 195 2.5E-72 T 17-03-2017 IPR004739 GMP synthase, N-terminal GO:0003922|GO:0005524|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00096 Glutamine amidotransferase superfamily signature 57 66 5.0E-7 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00096 Glutamine amidotransferase superfamily signature 173 186 5.0E-7 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00096 Glutamine amidotransferase superfamily signature 84 95 5.0E-7 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 SUPERFAMILY SSF52402 189 448 7.5E-57 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Pfam PF00958 GMP synthase C terminal domain 435 527 9.4E-39 T 17-03-2017 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 SUPERFAMILY SSF52317 13 202 3.01E-52 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Gene3D G3DSA:3.40.50.880 8 218 1.3E-57 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Gene3D G3DSA:3.40.50.620 219 402 6.9E-57 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 TIGRFAM TIGR00884 guaA_Cterm: GMP synthase (glutamine-hydrolyzing), C-terminal domain 208 528 9.5E-147 T 17-03-2017 IPR001674 GMP synthase, C-terminal GO:0003922|GO:0005524|GO:0006164|GO:0006177 KEGG: 00230+6.3.5.2|KEGG: 00983+6.3.5.2|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 SUPERFAMILY SSF54810 407 528 5.1E-47 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 84 100 1.2E-6 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 54 68 1.2E-6 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 13 27 1.2E-6 T 17-03-2017 SHXM_RS25420 19d7c25a9d28826f86695eed385e8bdf 528 Gene3D G3DSA:3.30.300.10 403 528 4.3E-49 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.30.70.250 701 765 3.9E-8 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.30.70.250 2263 2327 2.1E-8 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1529 1544 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF47336 3606 3693 1.57E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00826 2509 2677 3.1E-82 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.366.10 766 888 1.5E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.366.10 2123 2259 6.2E-85 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.366.10 564 698 1.5E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.366.10 2328 2455 6.2E-85 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00829 3010 3316 7.3E-186 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF50129 3025 3143 1.27E-26 T 17-03-2017 IPR011032 GroES-like SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1758 1774 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF52151 2328 2422 7.59E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF52151 2132 2264 7.59E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF55048 2263 2327 3.4E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF13602 Zinc-binding dehydrogenase 3185 3316 6.7E-17 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF00550 Phosphopantetheine attachment site 3617 3682 1.4E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF00550 Phosphopantetheine attachment site 1504 1570 3.0E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF47336 1498 1610 2.22E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1595 1845 8.8E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 6.4E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF14765 Polyketide synthase dehydratase 2509 2786 2.3E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.50.720 1221 1401 4.3E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.50.720 3326 3524 2.3E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF51735 3325 3528 1.55E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00825 Beta-ketoacyl synthase 1597 2023 1.2E-226 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00825 Beta-ketoacyl synthase 36 462 6.6E-226 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1853 1970 4.1E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 4.4E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.50.720 3143 3238 1.4E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF08990 Erythronolide synthase docking 2 27 4.4E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM01294 3615 3682 5.9E-5 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM01294 1503 1570 4.4E-6 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.90.180.10 3024 3142 5.1E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF53901 1593 1967 5.19E-108 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3641 3656 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3326 3506 5.8E-67 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1220 1399 8.1E-59 T 17-03-2017 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF51735 3110 3287 6.45E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF51735 992 1207 4.33E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF00698 Acyl transferase domain 576 894 1.6E-90 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF00698 Acyl transferase domain 2135 2459 4.3E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF52151 574 703 4.97E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF52151 767 865 4.97E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:1.10.1200.10 3610 3686 4.9E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:1.10.1200.10 1500 1574 1.2E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF51735 2794 2987 4.72E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.47.10 1593 1857 1.5E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.47.10 30 296 2.3E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.47.10 297 462 5.8E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Gene3D G3DSA:3.40.47.10 1858 2022 1.4E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1973 2099 3.2E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 539 9.6E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF55048 701 766 2.88E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF51735 1218 1444 2.23E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SUPERFAMILY SSF53901 31 408 1.17E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00823 Phosphopantetheine attachment site 1502 1574 1.0E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00823 Phosphopantetheine attachment site 3614 3686 3.7E-27 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2136 2441 1.2E-137 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 577 875 3.4E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 3138 3159 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF08659 KR domain 1220 1397 3.8E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45350 de15a65f96f5bbe2d305250c7e052526 3772 Pfam PF08659 KR domain 3326 3504 5.7E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 SUPERFAMILY SSF51604 99 364 1.7E-78 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 Pfam PF13378 Enolase C-terminal domain-like 137 357 7.2E-63 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 SMART SM00922 132 237 3.9E-23 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 SUPERFAMILY SSF54826 2 115 1.68E-27 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 17 111 2.3E-17 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 Gene3D G3DSA:3.20.20.120 117 355 4.0E-88 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS20365 22d40761d772dc81f21e53e7d9761abf 386 Gene3D G3DSA:3.30.390.10 10 116 2.5E-37 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS30890 2fc2f4adc99d4d254b6b6f53e39a0ca5 285 Gene3D G3DSA:3.40.50.720 1 218 7.1E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30890 2fc2f4adc99d4d254b6b6f53e39a0ca5 285 SUPERFAMILY SSF51735 3 252 1.14E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30890 2fc2f4adc99d4d254b6b6f53e39a0ca5 285 Pfam PF13460 NAD(P)H-binding 7 184 7.1E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 SMART SM01012 168 223 4.4E-20 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 Pfam PF03861 ANTAR domain 170 222 6.0E-19 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 SUPERFAMILY SSF55781 23 175 1.57E-15 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 PIRSF PIRSF036625 1 230 4.6E-88 T 17-03-2017 IPR012074 GAF-ANTAR transcription anti-termination regulator, putative SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 Pfam PF13185 GAF domain 21 163 3.5E-12 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 Gene3D G3DSA:1.10.10.10 174 226 4.0E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 SUPERFAMILY SSF52172 164 222 2.34E-9 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS10435 e4e1f965131ec9209a4ad7638c1022be 230 Gene3D G3DSA:3.30.450.40 9 173 3.4E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01705 bc4d6cccdb8b048229eb44fe56e30d26 234 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 8 97 4.6E-17 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS01705 bc4d6cccdb8b048229eb44fe56e30d26 234 Gene3D G3DSA:3.40.50.720 7 195 2.1E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01705 bc4d6cccdb8b048229eb44fe56e30d26 234 SUPERFAMILY SSF51735 8 198 3.71E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24990 7aef2ad9e01e09cf954b3ab4befe48cd 465 Pfam PF02447 GntP family permease 27 464 9.3E-142 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS24990 7aef2ad9e01e09cf954b3ab4befe48cd 465 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 27 465 6.1E-138 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS24990 7aef2ad9e01e09cf954b3ab4befe48cd 465 PIRSF PIRSF002746 20 465 1.2E-141 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 Gene3D G3DSA:1.10.579.10 274 449 6.1E-68 T 17-03-2017 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 ProSitePatterns PS00394 DNA photolyases class 1 signature 1. 311 323 - T 17-03-2017 IPR018394 Cryptochrome/DNA photolyase class 1, conserved site, C-terminal SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 SUPERFAMILY SSF48173 190 451 2.62E-94 T 17-03-2017 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain Reactome: R-HSA-1368108|Reactome: R-HSA-400253 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 SUPERFAMILY SSF52425 5 180 1.44E-33 T 17-03-2017 IPR006050 DNA photolyase, N-terminal Reactome: R-HSA-1368108|Reactome: R-HSA-400253 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 Pfam PF00875 DNA photolyase 8 159 3.1E-35 T 17-03-2017 IPR006050 DNA photolyase, N-terminal Reactome: R-HSA-1368108|Reactome: R-HSA-400253 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 Pfam PF03441 FAD binding domain of DNA photolyase 264 449 5.7E-70 T 17-03-2017 IPR005101 Cryptochrome/DNA photolyase, FAD-binding domain Reactome: R-HSA-1368108|Reactome: R-HSA-400253 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 Gene3D G3DSA:3.40.50.620 2 146 1.3E-35 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 PRINTS PR00147 DNA photolyase signature 141 157 9.5E-25 T 17-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 PRINTS PR00147 DNA photolyase signature 311 327 9.5E-25 T 17-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 PRINTS PR00147 DNA photolyase signature 331 349 9.5E-25 T 17-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 PRINTS PR00147 DNA photolyase signature 370 384 9.5E-25 T 17-03-2017 IPR002081 Cryptochrome/DNA photolyase class 1 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 Gene3D G3DSA:1.25.40.80 147 273 3.6E-33 T 17-03-2017 SHXM_RS14340 7e522226dda371516ba12911c06b410f 454 ProSitePatterns PS00691 DNA photolyases class 1 signature 2. 331 350 - T 17-03-2017 IPR018394 Cryptochrome/DNA photolyase class 1, conserved site, C-terminal SHXM_RS13350 3ad608e76f771091979b040eac918afd 246 Pfam PF00440 Bacterial regulatory proteins, tetR family 27 70 2.5E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13350 3ad608e76f771091979b040eac918afd 246 SUPERFAMILY SSF48498 98 234 1.82E-21 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS13350 3ad608e76f771091979b040eac918afd 246 SUPERFAMILY SSF46689 13 87 4.99E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13350 3ad608e76f771091979b040eac918afd 246 Gene3D G3DSA:1.10.357.10 12 234 4.1E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS13350 3ad608e76f771091979b040eac918afd 246 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 7.5E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13350 3ad608e76f771091979b040eac918afd 246 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 7.5E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 SUPERFAMILY SSF54427 6 138 4.27E-33 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 Pfam PF07366 SnoaL-like polyketide cyclase 10 132 2.4E-30 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 SMART SM00903 154 296 6.8E-53 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 SUPERFAMILY SSF50475 145 297 5.89E-46 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 Pfam PF01613 Flavin reductase like domain 155 296 2.3E-33 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 Gene3D G3DSA:3.10.450.50 11 141 7.2E-36 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06775 fa9fc6af85174c06a0e8d7283168a6a7 305 Gene3D G3DSA:2.30.110.10 142 294 9.7E-51 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS16460 540b9fddc1a27f28ff0e36ffdcb9ad6d 665 Gene3D G3DSA:3.50.50.60 4 199 1.2E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16460 540b9fddc1a27f28ff0e36ffdcb9ad6d 665 Pfam PF13454 FAD-NAD(P)-binding 10 192 1.1E-42 T 17-03-2017 SHXM_RS16460 540b9fddc1a27f28ff0e36ffdcb9ad6d 665 SUPERFAMILY SSF51905 4 193 2.42E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16460 540b9fddc1a27f28ff0e36ffdcb9ad6d 665 SUPERFAMILY SSF51905 578 621 2.42E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 Gene3D G3DSA:3.40.190.10 186 267 4.5E-15 T 17-03-2017 SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 Pfam PF03466 LysR substrate binding domain 87 271 1.3E-20 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 Gene3D G3DSA:1.10.10.10 1 77 8.6E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 59 2.2E-16 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 SUPERFAMILY SSF53850 90 280 1.81E-21 T 17-03-2017 SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 Gene3D G3DSA:3.40.190.10 78 185 8.6E-18 T 17-03-2017 SHXM_RS38110 3acae026b4aecb64a21084942f9e9215 299 SUPERFAMILY SSF46785 1 108 4.51E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 SUPERFAMILY SSF50129 1 174 1.42E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 Gene3D G3DSA:3.40.50.720 167 285 2.1E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 58 72 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 24 135 1.1E-25 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 Pfam PF00107 Zinc-binding dehydrogenase 175 300 2.6E-13 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 Gene3D G3DSA:3.90.180.10 1 166 1.8E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS50040 960e0e2ab3480f220f57c141d96ead27 361 SUPERFAMILY SSF51735 141 303 1.14E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40670 c3f0cfd79fd58a2bc7206baaba506af1 268 SUPERFAMILY SSF56529 7 260 5.34E-62 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS40670 c3f0cfd79fd58a2bc7206baaba506af1 268 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 102 258 8.4E-7 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS40670 c3f0cfd79fd58a2bc7206baaba506af1 268 Gene3D G3DSA:3.90.850.10 7 261 3.6E-66 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 Gene3D G3DSA:3.40.190.10 176 262 8.1E-20 T 17-03-2017 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 Gene3D G3DSA:3.40.190.10 89 175 2.1E-24 T 17-03-2017 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 1.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 1.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 1.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 SUPERFAMILY SSF53850 89 296 3.44E-32 T 17-03-2017 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 Pfam PF03466 LysR substrate binding domain 88 293 1.2E-34 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 63 3.9E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 Gene3D G3DSA:1.10.10.10 3 86 4.8E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03960 6ceae04aa3c506c3b33e469e25b41400 300 SUPERFAMILY SSF46785 4 86 4.84E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 Gene3D G3DSA:1.10.10.10 6 50 6.1E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 SUPERFAMILY SSF54909 67 150 5.9E-14 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 Pfam PF01037 Lrp/AsnC ligand binding domain 72 142 6.3E-12 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 Gene3D G3DSA:1.10.10.10 184 225 1.2E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 Gene3D G3DSA:3.30.70.920 70 142 2.8E-14 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 SMART SM00344 7 112 2.7E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 SMART SM00344 183 284 0.002 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 ProSitePatterns PS00519 AsnC-type HTH domain signature. 197 223 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 Pfam PF13404 AsnC-type helix-turn-helix domain 186 219 4.3E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 Pfam PF13404 AsnC-type helix-turn-helix domain 7 47 1.3E-11 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS23985 5a9bd55d659f1c0475ac2269f5431ca1 344 SUPERFAMILY SSF46785 183 234 1.2E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17690 1ab25327138f81aa7d7ef2a22a224c7f 306 Gene3D G3DSA:3.30.1780.10 2 131 4.3E-24 T 17-03-2017 IPR023401 Ornithine cyclodeaminase, N-terminal Reactome: R-HSA-71064 SHXM_RS17690 1ab25327138f81aa7d7ef2a22a224c7f 306 SUPERFAMILY SSF51735 2 303 1.02E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17690 1ab25327138f81aa7d7ef2a22a224c7f 306 Gene3D G3DSA:3.40.50.720 132 288 1.3E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17690 1ab25327138f81aa7d7ef2a22a224c7f 306 Pfam PF02423 Ornithine cyclodeaminase/mu-crystallin family 9 303 2.7E-50 T 17-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 SHXM_RS17690 1ab25327138f81aa7d7ef2a22a224c7f 306 PIRSF PIRSF001439 1 305 1.0E-55 T 17-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 3 257 9.6E-82 T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 Gene3D G3DSA:3.90.230.10 3 259 5.2E-76 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 SUPERFAMILY SSF55920 1 259 4.06E-71 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 ProSitePatterns PS00680 Methionine aminopeptidase subfamily 1 signature. 173 191 - T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 167 179 4.8E-21 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 200 212 4.8E-21 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 90 106 4.8E-21 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 PRINTS PR00599 Methionine aminopeptidase-1 signature 67 80 4.8E-21 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 Pfam PF00557 Metallopeptidase family M24 11 249 2.2E-41 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS31280 ba8274d241c5682eada3151b1f756f64 278 Hamap MF_01974 Methionine aminopeptidase [map]. 2 258 37.754 T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS05500 ff5415ddb06203e7b1b2151423cb4c04 447 SUPERFAMILY SSF103473 12 140 1.01E-10 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05500 ff5415ddb06203e7b1b2151423cb4c04 447 Pfam PF07690 Major Facilitator Superfamily 41 328 1.4E-14 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS05500 ff5415ddb06203e7b1b2151423cb4c04 447 Gene3D G3DSA:1.20.1250.20 27 221 8.7E-8 T 17-03-2017 SHXM_RS05500 ff5415ddb06203e7b1b2151423cb4c04 447 Gene3D G3DSA:1.20.1250.20 243 415 6.7E-13 T 17-03-2017 SHXM_RS05500 ff5415ddb06203e7b1b2151423cb4c04 447 SUPERFAMILY SSF103473 167 419 7.46E-21 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 Gene3D G3DSA:3.20.20.450 427 672 3.1E-91 T 17-03-2017 IPR001633 EAL domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 SUPERFAMILY SSF55073 256 406 7.61E-43 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 SMART SM00052 421 665 9.6E-102 T 17-03-2017 IPR001633 EAL domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 Pfam PF00990 Diguanylate cyclase, GGDEF domain 253 405 9.2E-40 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 SMART SM00267 245 411 4.1E-47 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 SUPERFAMILY SSF141868 427 672 5.23E-83 T 17-03-2017 IPR001633 EAL domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 Pfam PF00563 EAL domain 428 658 1.0E-70 T 17-03-2017 IPR001633 EAL domain SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 Gene3D G3DSA:3.30.70.270 253 413 3.2E-49 T 17-03-2017 SHXM_RS36085 e23ab981e5cf33f59554e87c69d9d961 702 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 251 405 9.0E-34 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS28280 6a354f44d37924b996084903759b40d1 217 SUPERFAMILY SSF52218 1 215 3.84E-36 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS28280 6a354f44d37924b996084903759b40d1 217 Gene3D G3DSA:3.40.50.360 1 214 5.7E-57 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS28280 6a354f44d37924b996084903759b40d1 217 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 2 208 25.758 T 17-03-2017 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SHXM_RS28280 6a354f44d37924b996084903759b40d1 217 Pfam PF02525 Flavodoxin-like fold 4 163 2.4E-31 T 17-03-2017 IPR003680 Flavodoxin-like fold SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 Gene3D G3DSA:3.30.70.250 134 198 4.6E-24 T 17-03-2017 SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 Pfam PF00698 Acyl transferase domain 35 291 2.9E-19 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 SUPERFAMILY SSF55048 137 192 1.2E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 Gene3D G3DSA:3.40.366.10 2 129 2.2E-50 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 Gene3D G3DSA:3.40.366.10 199 306 2.2E-50 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5 315 1.1E-17 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 SUPERFAMILY SSF52151 2 129 1.46E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS20305 2e9acb3a393198a872c298181644a3ac 331 SUPERFAMILY SSF52151 192 314 1.46E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 SMART SM01092 223 321 9.3E-27 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 SUPERFAMILY SSF55447 222 321 9.42E-28 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 Gene3D G3DSA:3.30.390.50 222 318 8.5E-33 T 17-03-2017 SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 Gene3D G3DSA:3.30.43.10 2 49 2.1E-14 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 Gene3D G3DSA:3.30.465.10 55 110 3.8E-36 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 Gene3D G3DSA:3.30.465.10 154 215 3.8E-36 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 225 319 1.1E-15 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 4 216 1.2E-49 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS10385 1a54a9bde508312e05f41c16b8849cd4 324 SUPERFAMILY SSF56176 3 216 1.04E-56 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 Gene3D G3DSA:2.40.110.10 121 219 9.3E-26 T 17-03-2017 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 121 217 3.2E-19 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 231 365 3.4E-31 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 10 116 1.2E-25 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 Gene3D G3DSA:1.10.540.10 9 117 6.1E-26 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 SUPERFAMILY SSF47203 227 384 9.67E-40 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 Gene3D G3DSA:1.20.140.10 220 385 7.9E-47 T 17-03-2017 SHXM_RS25600 a8fb290e00479736118f77c478a3d411 386 SUPERFAMILY SSF56645 10 242 6.81E-58 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 Pfam PF00455 DeoR C terminal sensor domain 77 232 8.0E-41 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 Gene3D G3DSA:3.40.50.1360 78 211 9.9E-6 T 17-03-2017 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 SUPERFAMILY SSF100950 79 233 3.14E-24 T 17-03-2017 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 Gene3D G3DSA:1.10.10.10 1 47 2.0E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 SMART SM01134 73 234 2.5E-56 T 17-03-2017 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 SUPERFAMILY SSF46785 4 68 3.36E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 8.4E-15 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 1.2E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 1.2E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS07750 9f5070e08f30a105dd94e89019844858 253 SMART SM00420 6 58 5.7E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 SUPERFAMILY SSF55781 73 252 4.38E-44 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 Gene3D G3DSA:3.30.450.40 77 253 1.1E-46 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 SMART SM00346 10 96 5.7E-17 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 Pfam PF09339 IclR helix-turn-helix domain 10 56 5.7E-12 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 Gene3D G3DSA:1.10.10.10 9 76 5.7E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 SUPERFAMILY SSF46785 10 80 1.33E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42130 c42ffb3cecf117c436c0f953a8c6e2fa 263 Pfam PF01614 Bacterial transcriptional regulator 126 248 5.0E-22 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS35470 48937407824548f3cb6f7dd6685f001c 451 SUPERFAMILY SSF103473 51 443 5.49E-29 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS35470 48937407824548f3cb6f7dd6685f001c 451 Pfam PF07690 Major Facilitator Superfamily 56 368 1.2E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS35470 48937407824548f3cb6f7dd6685f001c 451 Gene3D G3DSA:1.20.1250.20 264 441 1.6E-11 T 17-03-2017 SHXM_RS35470 48937407824548f3cb6f7dd6685f001c 451 Gene3D G3DSA:1.20.1250.20 50 232 1.9E-7 T 17-03-2017 SHXM_RS00805 ce3a5df5a8b6a2616f4156107e7ec4d9 121 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 8 116 7.7E-5 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS00805 ce3a5df5a8b6a2616f4156107e7ec4d9 121 PIRSF PIRSF039020 1 121 1.3E-39 T 17-03-2017 IPR026275 Glyoxalase/bleomycin resistance protein/dioxygenase SHXM_RS00805 ce3a5df5a8b6a2616f4156107e7ec4d9 121 SUPERFAMILY SSF54593 5 117 8.53E-18 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS00805 ce3a5df5a8b6a2616f4156107e7ec4d9 121 Gene3D G3DSA:3.10.180.10 7 117 1.2E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 SUPERFAMILY SSF68912 50 90 2.71E-5 T 17-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 SMART SM00959 50 92 2.2E-11 T 17-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Pfam PF07497 Rho termination factor, RNA-binding domain 350 424 8.4E-30 T 17-03-2017 IPR011113 Rho termination factor, RNA-binding GO:0003723|GO:0006353 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 TIGRFAM TIGR00767 rho: transcription termination factor Rho 51 713 1.6E-198 T 17-03-2017 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Pfam PF07498 Rho termination factor, N-terminal domain 51 88 6.9E-11 T 17-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 SUPERFAMILY SSF52540 388 666 7.25E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Hamap MF_01884 Transcription termination factor Rho [rho]. 342 715 203.174 T 17-03-2017 IPR004665 Transcription termination factor Rho GO:0003723|GO:0005524|GO:0006353|GO:0008186 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Gene3D G3DSA:2.40.50.140 345 424 1.5E-42 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Gene3D G3DSA:2.40.50.140 51 90 1.5E-42 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 SUPERFAMILY SSF50249 350 424 1.71E-17 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Gene3D G3DSA:3.40.50.300 431 713 3.4E-98 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 SMART SM00382 466 651 5.4E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 SMART SM00357 351 417 1.5E-11 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS35180 c3b0f040338b252ea1341309097f8a75 724 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 455 659 7.9E-20 T 17-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 SUPERFAMILY SSF52540 3 235 8.31E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 Gene3D G3DSA:3.40.50.300 3 234 1.0E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 Pfam PF00005 ABC transporter 20 163 2.1E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 Pfam PF13732 Domain of unknown function (DUF4162) 217 307 2.2E-8 T 17-03-2017 IPR025302 Domain of unknown function DUF4162 SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 12 309 2.6E-109 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS33200 5110731b8a1360587e94ff4adf0d67ec 328 SMART SM00382 29 212 4.5E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 Gene3D G3DSA:1.10.357.10 73 194 4.8E-25 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 7.3E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 7.3E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 Gene3D G3DSA:1.10.10.60 1 63 6.1E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 58 2.7E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 SUPERFAMILY SSF48498 80 193 1.8E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS45400 99fdbe59755c9c9782e3a3e9fc8ad6ac 202 SUPERFAMILY SSF46689 1 64 5.64E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Gene3D G3DSA:4.10.80.40 542 566 2.0E-6 T 17-03-2017 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 SUPERFAMILY SSF56425 252 369 1.94E-37 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Gene3D G3DSA:1.20.58.100 460 541 1.7E-20 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 SUPERFAMILY SSF46977 462 574 1.83E-30 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 TIGRFAM TIGR00551 nadB: L-aspartate oxidase 27 548 5.6E-166 T 17-03-2017 IPR005288 L-aspartate oxidase GO:0005737|GO:0008734|GO:0009435|GO:0055114 KEGG: 00250+1.4.3.16|KEGG: 00760+1.4.3.16|MetaCyc: PWY-5316|MetaCyc: PWY-7342 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Gene3D G3DSA:3.90.700.10 258 365 5.0E-36 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 30 49 1.2E-10 T 17-03-2017 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 372 394 1.2E-10 T 17-03-2017 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 PIRSF PIRSF000171 24 574 1.8E-41 T 17-03-2017 IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Gene3D G3DSA:3.50.50.60 21 257 4.9E-98 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Gene3D G3DSA:3.50.50.60 366 429 4.9E-98 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Pfam PF02910 Fumarate reductase flavoprotein C-term 464 574 1.4E-19 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 Pfam PF00890 FAD binding domain 29 409 4.3E-97 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 SUPERFAMILY SSF51905 373 425 4.54E-66 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 SUPERFAMILY SSF51905 19 281 4.54E-66 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 387 394 3.3E-6 T 17-03-2017 SHXM_RS26330 3d059b6eaa21df8b8d869c32992bf9b7 593 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 29 51 3.3E-6 T 17-03-2017 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Gene3D G3DSA:2.120.10.30 363 569 1.0E-35 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Gene3D G3DSA:2.120.10.30 570 641 2.5E-9 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 SUPERFAMILY SSF82171 363 636 2.75E-38 T 17-03-2017 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 SUPERFAMILY SSF51556 723 1020 6.32E-35 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 SUPERFAMILY SSF51338 648 724 8.86E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 SUPERFAMILY SSF51338 1019 1043 8.86E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 SUPERFAMILY SSF82171 61 273 9.02E-27 T 17-03-2017 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Pfam PF01979 Amidohydrolase family 957 1048 7.6E-13 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Pfam PF07676 WD40-like Beta Propeller Repeat 204 221 0.14 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Pfam PF07676 WD40-like Beta Propeller Repeat 424 442 0.0083 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Pfam PF07676 WD40-like Beta Propeller Repeat 103 127 2.9E-4 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Pfam PF07676 WD40-like Beta Propeller Repeat 562 578 0.093 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Pfam PF07676 WD40-like Beta Propeller Repeat 140 177 5.2E-9 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 18 40 4.2E-4 T 17-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Gene3D G3DSA:2.30.40.10 652 725 2.9E-20 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Gene3D G3DSA:2.30.40.10 1019 1061 2.9E-20 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Gene3D G3DSA:3.20.20.140 726 1016 1.8E-28 T 17-03-2017 SHXM_RS15800 1b41f9098825398f19e4b682482230c6 1099 Gene3D G3DSA:2.120.10.60 50 276 3.5E-40 T 17-03-2017 SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 SUPERFAMILY SSF50129 4 167 1.51E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 Gene3D G3DSA:3.90.180.10 1 173 4.0E-51 T 17-03-2017 IPR011032 GroES-like SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 SMART SM00829 13 334 1.0E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 SUPERFAMILY SSF51735 145 304 7.21E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 Pfam PF00107 Zinc-binding dehydrogenase 180 300 4.8E-18 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 61 75 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 Gene3D G3DSA:3.40.50.720 174 283 4.6E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25940 594f21b6572688da4bd1b4dab97a12e0 336 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 131 2.1E-22 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS23115 35fa2776d36e3f78f6d65d835ee1e95b 391 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 44 185 3.1E-14 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS23115 35fa2776d36e3f78f6d65d835ee1e95b 391 Gene3D G3DSA:3.40.47.10 7 183 9.8E-21 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23115 35fa2776d36e3f78f6d65d835ee1e95b 391 SUPERFAMILY SSF53901 7 219 1.04E-30 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS15515 9d37c7bd874222415cabd5f76e65e34d 279 Pfam PF01636 Phosphotransferase enzyme family 22 229 2.1E-13 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS15515 9d37c7bd874222415cabd5f76e65e34d 279 Gene3D G3DSA:3.90.1200.10 89 263 7.5E-13 T 17-03-2017 SHXM_RS15515 9d37c7bd874222415cabd5f76e65e34d 279 SUPERFAMILY SSF56112 24 269 2.92E-20 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 Pfam PF02780 Transketolase, C-terminal domain 199 319 2.1E-32 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 SUPERFAMILY SSF52922 196 327 5.37E-36 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 SUPERFAMILY SSF52518 7 186 1.12E-60 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 Pfam PF02779 Transketolase, pyrimidine binding domain 8 182 9.8E-44 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 SMART SM00861 9 183 4.3E-48 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 Gene3D G3DSA:3.40.50.970 7 198 2.5E-70 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS09210 969b54291db7f2f8db3b11304782f88a 329 Gene3D G3DSA:3.40.50.920 199 327 8.8E-38 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS24670 e4d4d0685f8d242dfd5c882051383715 408 Pfam PF16701 Adenylate cyclase regulatory domain 71 199 3.0E-8 T 17-03-2017 IPR032026 Adenylate cyclase regulatory domain SHXM_RS24670 e4d4d0685f8d242dfd5c882051383715 408 Gene3D G3DSA:3.30.70.1230 222 362 2.5E-19 T 17-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SHXM_RS24670 e4d4d0685f8d242dfd5c882051383715 408 Pfam PF00211 Adenylate and Guanylate cyclase catalytic domain 222 352 2.6E-13 T 17-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SHXM_RS24670 e4d4d0685f8d242dfd5c882051383715 408 SUPERFAMILY SSF55073 221 355 2.04E-30 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS24670 e4d4d0685f8d242dfd5c882051383715 408 SMART SM00044 108 361 8.7E-4 T 17-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SHXM_RS10150 a060c0e8f23d2a893082be8e9fc56577 104 SUPERFAMILY SSF46946 53 99 2.08E-5 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS10150 a060c0e8f23d2a893082be8e9fc56577 104 Gene3D G3DSA:1.10.8.50 49 94 1.1E-7 T 17-03-2017 SHXM_RS23635 79f3c8b9b6f07d4c3bf221d1dc9099b6 266 Pfam PF01522 Polysaccharide deacetylase 76 198 2.5E-27 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS23635 79f3c8b9b6f07d4c3bf221d1dc9099b6 266 SUPERFAMILY SSF88713 75 261 1.26E-50 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS23635 79f3c8b9b6f07d4c3bf221d1dc9099b6 266 Gene3D G3DSA:3.20.20.370 71 261 7.7E-51 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 Gene3D G3DSA:3.30.300.50 107 150 1.6E-4 T 17-03-2017 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 317 328 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 Gene3D G3DSA:2.40.10.10 179 266 1.6E-26 T 17-03-2017 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 Pfam PF00089 Trypsin 207 361 1.5E-11 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 Gene3D G3DSA:2.40.10.10 267 355 6.5E-32 T 17-03-2017 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 208 213 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 206 220 8.8E-43 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 289 306 8.8E-43 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 268 288 8.8E-43 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 308 331 8.8E-43 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 333 347 8.8E-43 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 SUPERFAMILY SSF50494 185 364 7.47E-39 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 PIRSF PIRSF001134 1 371 3.7E-127 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 Gene3D G3DSA:3.30.300.50 42 104 4.7E-7 T 17-03-2017 SHXM_RS03545 25001341f45f6d51d7dfe225f28c199b 405 Pfam PF02983 Alpha-lytic protease prodomain 106 161 3.1E-14 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS32425 06416119487233d12910beff7a25e6fe 199 SUPERFAMILY SSF100950 6 196 9.63E-43 T 17-03-2017 SHXM_RS32425 06416119487233d12910beff7a25e6fe 199 Pfam PF01812 5-formyltetrahydrofolate cyclo-ligase family 7 188 1.2E-41 T 17-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase SHXM_RS32425 06416119487233d12910beff7a25e6fe 199 Gene3D G3DSA:3.40.50.10420 7 194 3.1E-48 T 17-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SHXM_RS32425 06416119487233d12910beff7a25e6fe 199 PIRSF PIRSF006806 3 190 4.6E-30 T 17-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase SHXM_RS32425 06416119487233d12910beff7a25e6fe 199 TIGRFAM TIGR02727 MTHFS_bact: 5-formyltetrahydrofolate cyclo-ligase 7 188 8.3E-38 T 17-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 SUPERFAMILY SSF88659 112 172 1.25E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 18 173 1.7E-48 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 Pfam PF04542 Sigma-70 region 2 33 93 2.9E-10 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 Gene3D G3DSA:1.10.10.10 115 173 2.5E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 38 172 1.1E-21 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 Gene3D G3DSA:1.10.1740.10 20 93 5.1E-17 T 17-03-2017 SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 SUPERFAMILY SSF88946 23 100 1.8E-14 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS33320 5c6239b9cb61bee8908b15b94b5db277 189 Pfam PF08281 Sigma-70, region 4 116 169 1.9E-15 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34660 95bfec34451e4edf523891df8ab073d1 303 TIGRFAM TIGR03814 Gln_ase: glutaminase A 7 303 1.0E-122 T 17-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 SHXM_RS34660 95bfec34451e4edf523891df8ab073d1 303 Hamap MF_00313 Glutaminase [glsA]. 3 303 45.886 T 17-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 SHXM_RS34660 95bfec34451e4edf523891df8ab073d1 303 SUPERFAMILY SSF56601 2 303 1.35E-105 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS34660 95bfec34451e4edf523891df8ab073d1 303 Pfam PF04960 Glutaminase 21 303 9.5E-110 T 17-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 SHXM_RS34660 95bfec34451e4edf523891df8ab073d1 303 Gene3D G3DSA:3.40.710.10 2 303 8.4E-118 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 Pfam PF00449 Urease alpha-subunit, N-terminal domain 3 126 6.1E-54 T 17-03-2017 IPR011612 Urease alpha-subunit, N-terminal domain KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 407 422 1.3E-32 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 341 357 1.3E-32 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 302 319 1.3E-32 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 433 446 1.3E-32 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 SUPERFAMILY SSF51338 415 485 2.11E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 ProSitePatterns PS00145 Urease active site. 324 340 - T 17-03-2017 IPR017950 Urease active site GO:0009039 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 Gene3D G3DSA:3.20.20.140 151 435 7.5E-194 T 17-03-2017 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 Gene3D G3DSA:3.20.20.140 494 571 7.5E-194 T 17-03-2017 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 SUPERFAMILY SSF51556 487 573 2.15E-186 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 SUPERFAMILY SSF51556 136 438 2.15E-186 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 TIGRFAM TIGR01792 urease_alph: urease, alpha subunit 4 573 5.5E-270 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 Hamap MF_01953 Urease subunit alpha [ureC]. 2 573 55.702 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 Gene3D G3DSA:2.30.40.10 72 150 7.5E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 SUPERFAMILY SSF51338 2 184 1.59E-57 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 ProSitePatterns PS01120 Urease nickel ligands signature. 134 147 - T 17-03-2017 IPR029754 Urease nickel binding site GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08465 975b2655ed5e6a67ab6e3649304bdd05 573 Pfam PF01979 Amidohydrolase family 132 458 2.2E-67 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 Gene3D G3DSA:3.40.50.970 4 337 2.3E-113 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 Gene3D G3DSA:3.40.50.920 554 679 5.3E-50 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 Pfam PF02780 Transketolase, C-terminal domain 560 671 3.0E-12 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 SUPERFAMILY SSF52518 353 541 7.07E-61 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 SUPERFAMILY SSF52518 4 337 1.24E-102 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 SMART SM00861 367 539 4.9E-58 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 ProSitePatterns PS00802 Transketolase signature 2. 481 497 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 ProSitePatterns PS00801 Transketolase signature 1. 13 33 - T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 Pfam PF02779 Transketolase, pyrimidine binding domain 367 538 3.0E-38 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 TIGRFAM TIGR00232 tktlase_bact: transketolase 8 679 1.6E-236 T 17-03-2017 IPR005478 Transketolase, bacterial-like GO:0004802 KEGG: 00030+2.2.1.1|KEGG: 00710+2.2.1.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|MetaCyc: PWY-6901 SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 SUPERFAMILY SSF52922 549 680 1.44E-43 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 Gene3D G3DSA:3.40.50.970 347 545 1.2E-64 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13830 db860a7aa9474fa82214092624a79761 682 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 6 350 1.7E-125 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 ProSitePatterns PS00513 Adenylosuccinate synthetase active site. 131 142 - T 17-03-2017 IPR033128 Adenylosuccinate synthase, active site KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 SMART SM00788 3 422 6.2E-289 T 17-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 Gene3D G3DSA:3.40.440.10 194 264 9.9E-69 T 17-03-2017 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 Gene3D G3DSA:3.40.440.10 4 93 9.9E-69 T 17-03-2017 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 Pfam PF00709 Adenylosuccinate synthetase 5 421 2.7E-178 T 17-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 SUPERFAMILY SSF52540 3 425 3.72E-175 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 TIGRFAM TIGR00184 purA: adenylosuccinate synthase 5 424 2.3E-170 T 17-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 Gene3D G3DSA:3.90.170.10 266 423 1.1E-69 T 17-03-2017 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 Hamap MF_00011 Adenylosuccinate synthetase [purA]. 1 427 202.311 T 17-03-2017 IPR001114 Adenylosuccinate synthetase GO:0004019|GO:0005525|GO:0006164 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 Gene3D G3DSA:1.10.300.10 101 193 5.6E-35 T 17-03-2017 SHXM_RS29305 000568edc8de09ddd435e96e65bde27e 427 ProSitePatterns PS01266 Adenylosuccinate synthetase GTP-binding site. 10 17 - T 17-03-2017 IPR018220 Adenylosuccinate synthase, GTP-binding site GO:0005525 KEGG: 00230+6.3.4.4|KEGG: 00250+6.3.4.4|MetaCyc: PWY-7219|Reactome: R-HSA-73817 SHXM_RS15020 8d86ec9a544b1f0c79487b169abe66b2 101 Pfam PF14542 GCN5-related N-acetyl-transferase 13 88 2.7E-23 T 17-03-2017 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase SHXM_RS15020 8d86ec9a544b1f0c79487b169abe66b2 101 SUPERFAMILY SSF55729 4 92 6.52E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS15020 8d86ec9a544b1f0c79487b169abe66b2 101 Gene3D G3DSA:3.40.630.30 2 93 1.4E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33175 03570b02572f1bd96f97866b9633237d 387 Gene3D G3DSA:3.40.640.10 12 255 7.6E-101 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS33175 03570b02572f1bd96f97866b9633237d 387 ProSitePatterns PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 199 213 - T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS33175 03570b02572f1bd96f97866b9633237d 387 Gene3D G3DSA:3.90.1150.10 256 386 6.5E-49 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS33175 03570b02572f1bd96f97866b9633237d 387 SUPERFAMILY SSF53383 14 386 1.25E-120 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS33175 03570b02572f1bd96f97866b9633237d 387 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 14 386 4.1E-149 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS33175 03570b02572f1bd96f97866b9633237d 387 PIRSF PIRSF001434 1 387 5.4E-146 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS14615 cc734d364ecdb545486a511b1117451c 191 SUPERFAMILY SSF109854 4 138 1.74E-22 T 17-03-2017 SHXM_RS14615 cc734d364ecdb545486a511b1117451c 191 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 13 132 3.6E-14 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS14615 cc734d364ecdb545486a511b1117451c 191 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 12 173 3.7E-26 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS14615 cc734d364ecdb545486a511b1117451c 191 TIGRFAM TIGR03086 TIGR03086: TIGR03086 family protein 11 189 7.9E-53 T 17-03-2017 IPR017520 Conserved hypothetical protein CHP03086 SHXM_RS14615 cc734d364ecdb545486a511b1117451c 191 Gene3D G3DSA:1.20.120.450 6 59 1.7E-6 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Gene3D G3DSA:3.30.2060.10 149 224 3.0E-14 T 17-03-2017 SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Gene3D G3DSA:3.40.50.300 833 987 5.1E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SUPERFAMILY SSF52540 17 367 1.04E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Pfam PF02559 CarD-like/TRCF domain 507 606 3.7E-30 T 17-03-2017 IPR003711 CarD-like/TRCF domain SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SMART SM00490 857 941 3.9E-15 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SUPERFAMILY SSF52540 389 488 2.5E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Gene3D G3DSA:3.40.50.300 620 817 6.2E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Pfam PF00271 Helicase conserved C-terminal domain 841 940 8.5E-15 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SMART SM00982 1039 1137 1.8E-37 T 17-03-2017 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SMART SM01058 506 607 3.4E-46 T 17-03-2017 IPR003711 CarD-like/TRCF domain SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Pfam PF03461 TRCF domain 1040 1122 1.1E-24 T 17-03-2017 IPR005118 Transcription-repair-coupling factor, C-terminal domain GO:0006281 SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SUPERFAMILY SSF52540 557 814 1.09E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Pfam PF00270 DEAD/DEAH box helicase 638 798 2.2E-16 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SUPERFAMILY SSF141259 500 579 1.57E-17 T 17-03-2017 IPR003711 CarD-like/TRCF domain SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SUPERFAMILY SSF143517 1026 1180 1.22E-33 T 17-03-2017 SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 Hamap MF_00969 Transcription-repair-coupling factor [mfd]. 44 1132 28.553 T 17-03-2017 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SMART SM00487 631 830 9.9E-31 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 SUPERFAMILY SSF52540 813 1021 2.08E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32940 c24ce53f9bb79d793228f325152f5a90 1184 TIGRFAM TIGR00580 mfd: transcription-repair coupling factor 167 1112 0.0 T 17-03-2017 IPR004576 Transcription-repair coupling factor GO:0003684|GO:0005524|GO:0006281 SHXM_RS33705 a80d7bb545d734d4bf0241c24c3c691a 415 Pfam PF13560 Helix-turn-helix domain 7 64 8.4E-11 T 17-03-2017 SHXM_RS33705 a80d7bb545d734d4bf0241c24c3c691a 415 SMART SM00530 11 66 2.9E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS33705 a80d7bb545d734d4bf0241c24c3c691a 415 Gene3D G3DSA:1.10.260.40 7 61 1.0E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33705 a80d7bb545d734d4bf0241c24c3c691a 415 SUPERFAMILY SSF47413 1 62 2.53E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 Pfam PF00072 Response regulator receiver domain 17 128 3.2E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 199 211 1.9E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 199 1.9E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 183 1.9E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 SUPERFAMILY SSF52172 14 142 2.42E-30 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 Gene3D G3DSA:1.10.10.10 169 228 2.1E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 SMART SM00421 166 223 8.3E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 Pfam PF00196 Bacterial regulatory proteins, luxR family 168 223 3.1E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 Gene3D G3DSA:3.40.50.2300 13 168 3.1E-38 T 17-03-2017 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 ProSitePatterns PS00622 LuxR-type HTH domain signature. 183 210 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 SMART SM00448 15 127 2.3E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS35275 949e76fdc120f3899a7189cd88516edd 229 SUPERFAMILY SSF46894 158 228 1.26E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS39075 e7087a2dd726f9669467d1ee9249ad02 229 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 65 2.7E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39075 e7087a2dd726f9669467d1ee9249ad02 229 Gene3D G3DSA:1.10.357.10 8 203 8.3E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS39075 e7087a2dd726f9669467d1ee9249ad02 229 SUPERFAMILY SSF46689 7 91 7.98E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39075 e7087a2dd726f9669467d1ee9249ad02 229 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 1.9E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39075 e7087a2dd726f9669467d1ee9249ad02 229 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 1.9E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39075 e7087a2dd726f9669467d1ee9249ad02 229 SUPERFAMILY SSF48498 86 199 2.0E-8 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS03680 5d054055a8636343a89dceff6df2700f 273 Gene3D G3DSA:3.40.930.10 3 150 6.9E-43 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS03680 5d054055a8636343a89dceff6df2700f 273 SUPERFAMILY SSF52794 181 270 1.23E-11 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS03680 5d054055a8636343a89dceff6df2700f 273 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 7 146 1.5E-27 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS03680 5d054055a8636343a89dceff6df2700f 273 SUPERFAMILY SSF55804 4 147 1.44E-32 T 17-03-2017 IPR016152 Phosphotransferase/anion transporter GO:0005215|GO:0006810 Reactome: R-HSA-425381 SHXM_RS03680 5d054055a8636343a89dceff6df2700f 273 Gene3D G3DSA:3.40.50.270 182 266 7.0E-8 T 17-03-2017 SHXM_RS03680 5d054055a8636343a89dceff6df2700f 273 Pfam PF02302 PTS system, Lactose/Cellobiose specific IIB subunit 182 267 1.4E-8 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 SUPERFAMILY SSF52540 23 71 6.16E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 SUPERFAMILY SSF52540 329 460 6.16E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Pfam PF00005 ABC transporter 508 718 3.7E-10 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:1.20.1580.10 556 678 2.7E-36 T 17-03-2017 SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:3.40.50.300 679 796 1.0E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:3.40.50.300 14 70 4.0E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:3.40.50.300 368 481 4.0E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:3.40.50.300 491 552 1.0E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:1.10.8.280 192 293 2.8E-4 T 17-03-2017 SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:1.20.1580.10 111 188 2.3E-30 T 17-03-2017 SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 Gene3D G3DSA:1.20.1580.10 301 367 2.3E-30 T 17-03-2017 SHXM_RS43540 0163eb707fbb89fb4789f46e3ef32d74 800 SUPERFAMILY SSF52540 501 771 2.08E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 SMART SM00967 33 104 8.6E-15 T 17-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 33 101 1.5E-11 T 17-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 SUPERFAMILY SSF75217 92 267 3.07E-40 T 17-03-2017 IPR029028 Alpha/beta knot methyltransferases SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 Pfam PF00588 SpoU rRNA Methylase family 115 259 8.7E-36 T 17-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 Gene3D G3DSA:3.30.1330.30 5 100 7.5E-30 T 17-03-2017 IPR029064 50S ribosomal protein L30e-like SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 Gene3D G3DSA:3.40.1280.10 111 266 2.8E-48 T 17-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SHXM_RS13130 a5eac0c52b8bcadf66df849971daaaed 277 SUPERFAMILY SSF55315 5 100 1.13E-20 T 17-03-2017 IPR029064 50S ribosomal protein L30e-like SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 5308 5525 7.08E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.47.10 29 296 1.2E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.47.10 1802 2066 2.1E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 4260 4380 1.0E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2182 2301 7.3E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 535 1.9E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF55048 2460 2521 3.79E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00826 4779 4942 1.5E-87 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00826 934 1104 3.0E-87 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00826 2698 2861 8.6E-90 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5626 5641 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 1423 1671 3.18E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00829 3183 3489 9.7E-191 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF08990 Erythronolide synthase docking 2 27 6.0E-13 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 5151 5295 7.81E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 5063 5123 7.81E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.50.720 3318 3411 3.8E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 3493 3740 5.67E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF52151 2514 2620 7.59E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF52151 2334 2455 7.59E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.50.720 3498 3683 2.0E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.50.720 5309 5505 4.2E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.50.720 1425 1629 3.7E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM01294 1711 1778 1.7E-5 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM01294 3786 3853 4.1E-6 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM01294 5600 5667 9.1E-7 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF13602 Zinc-binding dehydrogenase 3358 3489 2.2E-18 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF14765 Polyketide synthase dehydratase 4779 5053 7.8E-59 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF14765 Polyketide synthase dehydratase 934 1215 1.8E-57 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF14765 Polyketide synthase dehydratase 2698 2971 3.1E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1967 1983 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 3282 3418 2.63E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 3311 3332 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1737 1752 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF53901 3879 4254 9.49E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF52151 759 862 3.66E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF52151 570 698 3.66E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 4045 4061 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00550 Phosphopantetheine attachment site 1713 1778 4.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00550 Phosphopantetheine attachment site 5601 5667 2.7E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00550 Phosphopantetheine attachment site 3787 3853 4.7E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:1.10.1200.10 1709 1782 5.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:1.10.1200.10 3783 3857 1.6E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:1.10.1200.10 5596 5671 2.3E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF55048 697 758 1.29E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.30.70.250 4544 4603 4.5E-6 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.30.70.250 2460 2520 2.6E-7 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.30.70.250 697 757 1.3E-6 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 3203 3259 2.3E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.47.10 297 464 3.7E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.47.10 2067 2233 4.9E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.47.10 4145 4311 1.7E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF53901 1799 2176 9.71E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF47336 3780 3896 1.96E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.90.180.10 3198 3317 1.3E-44 T 17-03-2017 IPR011032 GroES-like SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF47336 1705 1819 6.67E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF47336 5592 5679 8.9E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3499 3679 1.2E-64 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5310 5490 1.1E-58 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1425 1605 1.0E-58 T 17-03-2017 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 1223 1410 1.14E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 4140 4257 3.5E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2062 2179 4.3E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 1.7E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF55048 4543 4604 2.09E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.47.10 3884 4144 2.3E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00698 Acyl transferase domain 4420 4706 5.5E-54 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00698 Acyl transferase domain 573 885 1.5E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00698 Acyl transferase domain 2336 2648 3.4E-53 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2337 2630 5.4E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 574 880 1.2E-122 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 4420 4712 2.3E-127 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF53901 30 408 8.16E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00825 Beta-ketoacyl synthase 1806 2232 5.3E-228 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00825 Beta-ketoacyl synthase 36 462 1.5E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00825 Beta-ketoacyl synthase 3884 4310 7.5E-230 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF08659 KR domain 3499 3678 1.4E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF08659 KR domain 1425 1604 5.9E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF08659 KR domain 5310 5488 1.8E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1804 2054 2.4E-86 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 1.3E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3882 4132 1.2E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF51735 2979 3160 1.57E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.366.10 758 869 3.0E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.366.10 4604 4716 2.7E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.366.10 2331 2455 1.1E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.366.10 2521 2632 1.1E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.366.10 4413 4538 2.7E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 Gene3D G3DSA:3.40.366.10 568 692 3.0E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00823 Phosphopantetheine attachment site 1710 1782 1.2E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00823 Phosphopantetheine attachment site 5599 5671 2.0E-36 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SMART SM00823 Phosphopantetheine attachment site 3785 3857 4.1E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF52151 4597 4701 1.86E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF52151 4417 4538 1.86E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22145 384fb5a62447205a44f409a22804d249 5752 SUPERFAMILY SSF50129 3180 3320 7.86E-28 T 17-03-2017 IPR011032 GroES-like SHXM_RS48440 7aa0df4c843415b3c6f3d8755a8df1ab 553 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 84 427 3.9E-57 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS48440 7aa0df4c843415b3c6f3d8755a8df1ab 553 Gene3D G3DSA:3.40.190.10 193 294 7.2E-15 T 17-03-2017 SHXM_RS48440 7aa0df4c843415b3c6f3d8755a8df1ab 553 Gene3D G3DSA:3.90.76.10 57 192 2.9E-30 T 17-03-2017 SHXM_RS48440 7aa0df4c843415b3c6f3d8755a8df1ab 553 SUPERFAMILY SSF53850 47 533 8.69E-79 T 17-03-2017 SHXM_RS48440 7aa0df4c843415b3c6f3d8755a8df1ab 553 Gene3D G3DSA:3.10.105.10 295 508 1.0E-31 T 17-03-2017 SHXM_RS48440 7aa0df4c843415b3c6f3d8755a8df1ab 553 PIRSF PIRSF002741 1 533 1.4E-68 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 Gene3D G3DSA:3.20.20.10 63 303 9.0E-87 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 322 425 1.1E-13 T 17-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 SUPERFAMILY SSF50621 294 448 1.49E-48 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 TIGRFAM TIGR01048 lysA: diaminopimelate decarboxylase 35 447 5.5E-128 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 SUPERFAMILY SSF51419 53 317 1.24E-74 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 406 419 9.6E-19 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 102 114 9.6E-19 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 216 229 9.6E-19 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 305 324 9.6E-19 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 82 100 9.6E-19 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01181 Diaminopimelate decarboxylase signature 188 197 1.5E-25 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01181 Diaminopimelate decarboxylase signature 416 438 1.5E-25 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01181 Diaminopimelate decarboxylase signature 100 117 1.5E-25 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 PRINTS PR01181 Diaminopimelate decarboxylase signature 333 351 1.5E-25 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 63 315 4.2E-56 T 17-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 ProSitePatterns PS00878 Orn/DAP/Arg decarboxylases family 2 pyridoxal-P attachment site. 82 100 - T 17-03-2017 IPR022653 Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 ProSitePatterns PS00879 Orn/DAP/Arg decarboxylases family 2 signature 2. 255 268 - T 17-03-2017 IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 Gene3D G3DSA:2.40.37.10 304 448 3.4E-45 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS13745 25b8c0e2a1fd4857cdfb9d2f72273926 451 Hamap MF_02120 Diaminopimelate decarboxylase [lysA]. 42 449 39.333 T 17-03-2017 IPR002986 Diaminopimelate decarboxylase, LysA GO:0008836|GO:0009089 KEGG: 00300+4.1.1.20|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 SUPERFAMILY SSF55424 341 460 4.47E-30 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 SUPERFAMILY SSF51905 3 333 1.19E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 Gene3D G3DSA:3.30.390.30 344 460 1.4E-28 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 339 360 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 176 201 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 38 53 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 140 149 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 261 275 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 426 446 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 404 419 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 5 27 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 304 311 8.2E-55 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 324 1.7E-55 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 137 155 3.4E-34 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 3.4E-34 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 289 311 3.4E-34 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 176 194 3.4E-34 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 260 276 3.4E-34 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 Gene3D G3DSA:3.50.50.60 3 141 4.9E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 344 451 5.4E-25 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 PIRSF PIRSF000350 1 464 3.9E-67 T 17-03-2017 SHXM_RS06735 820def617cddcffdb16d4fd2ff9eaa7a 467 Gene3D G3DSA:3.50.50.60 142 332 1.5E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 Gene3D G3DSA:3.40.50.1390 1 121 5.0E-35 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 Pfam PF00239 Resolvase, N terminal domain 3 137 1.6E-36 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 SMART SM00857 2 138 1.5E-44 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 Pfam PF02796 Helix-turn-helix domain of resolvase 140 179 1.2E-6 T 17-03-2017 IPR006120 Resolvase, HTH domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 SUPERFAMILY SSF53041 1 137 1.12E-38 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 Gene3D G3DSA:1.10.10.60 140 183 2.6E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 SUPERFAMILY SSF46689 140 183 1.29E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08840 ac696a686f6c2182b3f5e85fd8df559e 200 ProSitePatterns PS00397 Site-specific recombinases active site. 5 13 - T 17-03-2017 IPR006118 Recombinase, conserved site GO:0000150|GO:0006310 SHXM_RS47930 19c8b54ecafd204b639d33d7d6cf9018 54 Gene3D G3DSA:1.10.357.10 2 52 2.4E-8 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47930 19c8b54ecafd204b639d33d7d6cf9018 54 Pfam PF00440 Bacterial regulatory proteins, tetR family 4 37 1.6E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47930 19c8b54ecafd204b639d33d7d6cf9018 54 SUPERFAMILY SSF46689 2 53 4.77E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 ProSitePatterns PS00544 Methylmalonyl-CoA mutase signature. 365 390 - T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 TIGRFAM TIGR00642 mmCoA_mut_beta: methylmalonyl-CoA mutase, small subunit 9 627 2.4E-192 T 17-03-2017 IPR004608 Methylmalonyl-CoA mutase, beta chain GO:0004494|GO:0019652|GO:0031419 KEGG: 00280+5.4.99.2|KEGG: 00630+5.4.99.2|KEGG: 00640+5.4.99.2|KEGG: 00720+5.4.99.2|MetaCyc: PWY-5743|MetaCyc: PWY-5789|MetaCyc: PWY-6728|MetaCyc: PWY-7384 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 Gene3D G3DSA:3.40.50.280 492 626 7.6E-54 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 Pfam PF01642 Methylmalonyl-CoA mutase 52 534 3.9E-139 T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 Gene3D G3DSA:1.10.196.20 7 32 7.5E-9 T 17-03-2017 IPR024067 Methylmalonyl-CoA mutase small subunit, N-terminal KEGG: 00280+5.4.99.2|KEGG: 00630+5.4.99.2|KEGG: 00640+5.4.99.2|KEGG: 00720+5.4.99.2|MetaCyc: PWY-5743|MetaCyc: PWY-5789|MetaCyc: PWY-6728|MetaCyc: PWY-7384 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 Gene3D G3DSA:3.20.20.240 52 486 8.4E-142 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 SUPERFAMILY SSF52242 498 622 1.47E-6 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS07355 dd1974857af3e57039ffa5f7586753f4 627 SUPERFAMILY SSF51703 9 541 6.67E-155 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS16020 83c6cc7f47fbe1893d7872aace281dbe 326 SUPERFAMILY SSF51430 1 307 1.7E-63 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS16020 83c6cc7f47fbe1893d7872aace281dbe 326 Gene3D G3DSA:3.20.20.100 1 307 1.0E-57 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS16020 83c6cc7f47fbe1893d7872aace281dbe 326 Pfam PF00248 Aldo/keto reductase family 10 307 2.6E-44 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 SUPERFAMILY SSF52922 201 336 3.93E-35 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 SUPERFAMILY SSF52518 13 196 6.68E-66 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 Pfam PF02780 Transketolase, C-terminal domain 219 330 4.1E-35 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 Gene3D G3DSA:3.40.50.920 220 334 9.9E-39 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 Gene3D G3DSA:3.40.50.970 12 207 1.7E-72 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 Pfam PF02779 Transketolase, pyrimidine binding domain 14 187 8.4E-45 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS28375 3c39cbd06989813f3b6d5deae4628413 349 SMART SM00861 14 189 2.8E-66 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 Gene3D G3DSA:1.20.140.10 206 359 7.4E-15 T 17-03-2017 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 Gene3D G3DSA:1.10.540.10 2 89 4.9E-18 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 SUPERFAMILY SSF56645 7 212 2.88E-29 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 SUPERFAMILY SSF47203 221 354 3.22E-9 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 Gene3D G3DSA:2.40.110.10 141 205 8.1E-7 T 17-03-2017 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 11 101 5.8E-12 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 PIRSF PIRSF016578 1 365 1.0E-21 T 17-03-2017 SHXM_RS15425 d698b88a187669af2d25647e16a89d3a 378 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 230 353 7.3E-8 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 SUPERFAMILY SSF46689 253 303 1.48E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 Gene3D G3DSA:2.60.120.280 34 177 3.6E-6 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 SMART SM00342 217 300 3.4E-30 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 Pfam PF12833 Helix-turn-helix domain 223 302 6.2E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 Gene3D G3DSA:1.10.10.60 255 302 2.4E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 SUPERFAMILY SSF51215 32 82 3.01E-6 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 Gene3D G3DSA:1.10.10.60 199 254 9.6E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 SUPERFAMILY SSF46689 200 251 1.02E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 Pfam PF12852 Cupin 2 184 4.7E-35 T 17-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain SHXM_RS46900 892c0ea1d28a300bd6e5ff91c8c6627a 305 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 254 296 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS33845 6090bcf881a06882814f5c43a7a5c01b 547 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 91 466 5.1E-52 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS33845 6090bcf881a06882814f5c43a7a5c01b 547 Gene3D G3DSA:3.90.76.10 57 218 2.6E-37 T 17-03-2017 SHXM_RS33845 6090bcf881a06882814f5c43a7a5c01b 547 Gene3D G3DSA:3.10.105.10 328 515 8.6E-41 T 17-03-2017 SHXM_RS33845 6090bcf881a06882814f5c43a7a5c01b 547 SUPERFAMILY SSF53850 43 542 6.15E-92 T 17-03-2017 SHXM_RS33845 6090bcf881a06882814f5c43a7a5c01b 547 PIRSF PIRSF002741 5 543 9.2E-69 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS33845 6090bcf881a06882814f5c43a7a5c01b 547 Gene3D G3DSA:3.40.190.10 219 327 8.5E-22 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.47.10 37 297 2.1E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.47.10 2121 2381 3.0E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF51735 1738 1932 2.33E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2119 2369 7.3E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 2.0E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF51735 1529 1701 5.69E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2497 2624 3.2E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 547 2.3E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF13602 Zinc-binding dehydrogenase 1616 1730 1.4E-15 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00823 Phosphopantetheine attachment site 2023 2095 6.2E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00823 Phosphopantetheine attachment site 3798 3870 2.4E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:1.10.1200.10 2022 2096 4.5E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:1.10.1200.10 3794 3871 8.0E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF00550 Phosphopantetheine attachment site 2025 2091 1.2E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF00550 Phosphopantetheine attachment site 3801 3866 2.4E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.90.180.10 1441 1563 2.2E-44 T 17-03-2017 IPR011032 GroES-like SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.366.10 577 710 6.2E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.366.10 779 888 6.2E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF00698 Acyl transferase domain 2662 2980 1.8E-83 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF00698 Acyl transferase domain 584 906 1.9E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF55048 715 779 3.79E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1450 1505 2.9E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.30.70.250 715 778 1.4E-7 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.30.70.250 2788 2852 6.0E-9 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF52151 2854 2952 1.46E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF52151 2660 2789 1.46E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3825 3840 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF08659 KR domain 1740 1918 1.8E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF08659 KR domain 3510 3688 8.1E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2050 2065 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF51735 1235 1411 1.73E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.50.720 1564 1652 9.4E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2377 2494 2.4E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 5.8E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00825 Beta-ketoacyl synthase 37 463 3.8E-218 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00825 Beta-ketoacyl synthase 2121 2547 1.4E-219 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00826 3029 3197 2.3E-78 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00826 954 1118 1.9E-75 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF53901 32 408 2.66E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF14765 Polyketide synthase dehydratase 954 1230 4.3E-62 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Pfam PF14765 Polyketide synthase dehydratase 3029 3309 2.6E-59 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF47336 2016 2104 4.58E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3510 3690 1.5E-56 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1740 1920 1.0E-58 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.47.10 298 465 1.7E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.47.10 2382 2548 5.7E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.50.720 3510 3717 3.8E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.50.720 1739 1923 3.0E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00829 1430 1730 2.0E-174 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF53901 2117 2492 9.62E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF50129 1428 1566 5.03E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF51735 3319 3497 2.46E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF51735 3507 3741 6.43E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.366.10 2853 2976 2.7E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 Gene3D G3DSA:3.40.366.10 2652 2784 2.7E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF47336 3790 3870 5.23E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM01294 3799 3866 4.6E-4 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM01294 2024 2091 2.4E-6 T 17-03-2017 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2282 2298 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2664 2963 7.2E-122 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 584 887 4.6E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF52151 780 883 5.49E-73 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF52151 580 716 5.49E-73 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42860 17aefea2b2d560e84b9d3f1509c65557 3874 SUPERFAMILY SSF55048 2788 2853 1.31E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 PRINTS PR01036 Tetracycline resistance protein TetB signature 421 440 1.8E-7 T 17-03-2017 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 PRINTS PR01036 Tetracycline resistance protein TetB signature 158 182 1.8E-7 T 17-03-2017 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 PRINTS PR01036 Tetracycline resistance protein TetB signature 36 60 1.8E-7 T 17-03-2017 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 Gene3D G3DSA:1.20.1250.20 286 441 3.8E-15 T 17-03-2017 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 Gene3D G3DSA:1.20.1250.20 34 214 4.4E-30 T 17-03-2017 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 Gene3D G3DSA:1.20.1250.20 493 520 3.8E-15 T 17-03-2017 SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 SUPERFAMILY SSF103473 269 440 3.53E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 SUPERFAMILY SSF103473 492 517 3.53E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 SUPERFAMILY SSF103473 27 220 3.53E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16950 6661aeefc8712be1567e30e70560287e 556 Pfam PF07690 Major Facilitator Superfamily 38 430 1.7E-46 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 SUPERFAMILY SSF55103 244 509 2.22E-31 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 Pfam PF01565 FAD binding domain 93 228 6.8E-32 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 SUPERFAMILY SSF56176 48 268 1.07E-48 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 Gene3D G3DSA:3.30.465.10 147 268 1.2E-25 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 Gene3D G3DSA:3.30.43.10 45 146 9.3E-20 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 Pfam PF02913 FAD linked oxidases, C-terminal domain 268 505 8.2E-28 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS40715 6e0ddff67c604fae3f863954b2d07837 517 Gene3D G3DSA:1.10.45.10 467 507 1.7E-9 T 17-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SHXM_RS02575 177d3734fddbb3300840fd59c5258b58 593 Pfam PF16861 Carbamoyltransferase C-terminus 419 590 9.6E-72 T 17-03-2017 IPR031730 Carbamoyltransferase, C-terminal SHXM_RS02575 177d3734fddbb3300840fd59c5258b58 593 SUPERFAMILY SSF53067 153 240 2.72E-9 T 17-03-2017 SHXM_RS02575 177d3734fddbb3300840fd59c5258b58 593 SUPERFAMILY SSF53067 34 99 2.72E-9 T 17-03-2017 SHXM_RS02575 177d3734fddbb3300840fd59c5258b58 593 SUPERFAMILY SSF53067 273 368 2.72E-9 T 17-03-2017 SHXM_RS02575 177d3734fddbb3300840fd59c5258b58 593 Pfam PF02543 Carbamoyltransferase N-terminus 32 365 5.9E-43 T 17-03-2017 IPR003696 Carbamoyltransferase GO:0003824|GO:0009058 SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 SMART SM00871 126 284 1.2E-23 T 17-03-2017 IPR010499 Bacterial transcription activator, effector binding SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 Gene3D G3DSA:1.10.10.60 3 55 2.3E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 Gene3D G3DSA:3.20.80.10 114 284 3.6E-24 T 17-03-2017 IPR011256 Regulatory factor, effector binding domain SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 Pfam PF12833 Helix-turn-helix domain 25 103 2.8E-16 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 SUPERFAMILY SSF46689 55 106 3.18E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 Gene3D G3DSA:1.10.10.60 56 113 1.3E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 SUPERFAMILY SSF46689 3 53 1.7E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 Pfam PF06445 GyrI-like small molecule binding domain 126 283 5.3E-23 T 17-03-2017 IPR029442 GyrI-like small molecule binding domain SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 SUPERFAMILY SSF55136 126 285 3.4E-20 T 17-03-2017 IPR011256 Regulatory factor, effector binding domain SHXM_RS45460 ba8aaaf38dde77d7db0b12b1668b1fee 288 SMART SM00342 19 102 7.7E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00826 10047 10213 2.7E-70 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00826 4747 4913 3.1E-85 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00826 3419 3592 1.6E-83 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 9806 9871 7.32E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 11313 11434 3.5E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 4227 4347 2.1E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1415 1505 1.6E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 9520 9644 1.6E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 6383 6517 4.1E-10 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 7967 8058 3.0E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2903 3010 2.3E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 385 508 3.4E-18 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7191 7370 9.6E-49 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 12114 12293 6.0E-60 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8757 8936 4.9E-57 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5579 5759 1.1E-53 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 10544 10724 5.1E-54 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2152 2331 5.1E-57 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 941 1051 2.62E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 2520 2898 9.23E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 670 735 5.49E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 7846 7964 2.6E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2783 2900 4.5E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 9400 9517 1.6E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 6263 6380 3.2E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 11192 11310 5.6E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 4107 4224 4.7E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1294 1412 1.8E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 264 382 7.9E-39 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 6168 6184 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF50129 5276 5396 4.25E-28 T 17-03-2017 IPR011032 GroES-like SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 5397 5491 3.7E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 545 862 7.7E-88 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 1573 1850 4.4E-53 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 3058 3371 4.4E-91 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 9681 9998 1.2E-87 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 6555 6869 6.3E-91 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 11471 11786 1.6E-57 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 8126 8403 2.6E-49 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00698 Acyl transferase domain 4384 4697 3.2E-90 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 7751 7767 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 1752 1860 4.45E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 1570 1690 4.45E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 2429 2538 3.27E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF13602 Zinc-binding dehydrogenase 5439 5569 4.0E-16 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2459 2474 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 5862 5942 4.32E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 8123 8243 4.45E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 8305 8413 4.45E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 5035 5240 9.84E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 5284 5338 2.1E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 11467 11594 1.26E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 11658 11754 1.26E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 736 833 2.62E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 543 672 2.62E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 9871 9980 3.2E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 9680 9802 3.2E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.90.180.10 5278 5396 1.8E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 6676 6741 1.96E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 6742 6840 6.28E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 6553 6678 6.28E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 8753 9003 1.01E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 3054 3180 7.59E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 3244 3342 7.59E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 5362 5495 3.59E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 7474 7603 3.27E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1199 1215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 1928 2138 9.05E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF14765 Polyketide synthase dehydratase 4747 5028 2.4E-61 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF14765 Polyketide synthase dehydratase 3419 3703 2.3E-53 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF14765 Polyketide synthase dehydratase 10047 10324 2.1E-48 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 11889 12100 3.54E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 3178 3243 1.09E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00012 Phosphopantetheine attachment site. 9073 9088 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 4012 4028 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 3846 4221 5.9E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 534 667 1.9E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 1568 1691 4.8E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 1760 1878 4.8E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 6741 6863 7.8E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 735 857 1.9E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 6543 6673 7.8E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 4570 4692 2.3E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 4375 4502 2.3E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 10826 10949 2.88E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 3845 4111 1.5E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 11 268 2.3E-84 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 6000 6371 6.82E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 7191 7405 3.6E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 10545 10745 1.5E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 5579 5791 6.7E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 8757 8954 1.8E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 2152 2351 7.2E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.50.720 12114 12325 4.0E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 5577 5810 1.08E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 2432 2504 2.3E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 5868 5940 5.2E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 3754 3826 3.1E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 10832 10904 4.0E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 7481 7553 1.5E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 12403 12475 1.3E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 9046 9118 2.8E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00823 Phosphopantetheine attachment site 944 1016 1.6E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08659 KR domain 10544 10723 1.3E-51 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08659 KR domain 7191 7368 1.1E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08659 KR domain 12114 12292 8.0E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08659 KR domain 5579 5758 3.0E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08659 KR domain 8757 8935 1.5E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08659 KR domain 2152 2330 3.0E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 8532 8744 1.87E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF08990 Erythronolide synthase docking 5981 5997 1.5E-4 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1573 1865 8.9E-122 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3058 3352 7.4E-127 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 11471 11768 1.5E-123 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 8126 8418 4.9E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 546 844 3.6E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 9682 9980 2.1E-129 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 6556 6850 1.7E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 4385 4679 4.1E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00012 Phosphopantetheine attachment site. 10859 10874 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 10 379 9.76E-82 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00012 Phosphopantetheine attachment site. 12430 12445 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 10543 10782 5.75E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 12395 12481 5.76E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 12110 12348 1.32E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 12404 12471 3.8E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 945 1012 7.9E-5 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 2433 2500 2.4E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 7482 7549 5.4E-5 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 5873 5936 6.2E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 9047 9114 3.8E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 3755 3822 6.5E-5 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM01294 10833 10900 7.5E-7 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00012 Phosphopantetheine attachment site. 7508 7523 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 5871 5936 1.0E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 7483 7549 1.3E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 2434 2500 3.6E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 12406 12471 7.0E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 946 1012 1.8E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 9048 9114 6.9E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 10835 10900 8.5E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00550 Phosphopantetheine attachment site 3757 3822 1.3E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 7588 7838 9.9E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6004 6255 1.9E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 14 256 3.6E-72 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 9142 9392 2.9E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2524 2775 5.9E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3849 4099 2.0E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1036 1286 1.4E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 10934 11184 2.7E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00829 5264 5569 5.2E-183 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 4505 4570 1.83E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 8248 8312 1.44E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5895 5910 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 9042 9118 7.3E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 7479 7553 7.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 2430 2503 6.5E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 12401 12475 2.9E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 5864 5941 2.4E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 3752 3826 1.8E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 941 1016 2.0E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:1.10.1200.10 10829 10903 1.0E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 10929 11308 1.59E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 3051 3174 9.9E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 11657 11771 5.3E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 8121 8243 5.3E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 11466 11588 5.3E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 3243 3356 9.9E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.366.10 8312 8417 5.3E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 9041 9156 1.44E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF47336 3749 3864 1.11E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 6268 6433 6.6E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 4112 4276 1.9E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 9405 9570 3.0E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 2788 2952 1.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 11197 11365 3.9E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 1299 1464 3.9E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 269 439 5.4E-57 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 7851 8015 2.8E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 10936 11196 6.2E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 6006 6267 4.5E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 1038 1298 3.0E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 2526 2787 8.4E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 7590 7850 1.4E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.40.47.10 9144 9404 1.1E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 9679 9808 2.25E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 9872 9971 2.25E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 1032 1409 3.11E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 11097 11113 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 10330 10528 3.35E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 2151 2375 2.45E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 8248 8311 7.5E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 11592 11656 6.2E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 670 734 3.1E-7 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 9806 9870 2.2E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 4505 4569 1.6E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 1695 1759 9.4E-6 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 3178 3242 1.1E-7 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 Gene3D G3DSA:3.30.70.250 6676 6740 1.7E-8 T 17-03-2017 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 1695 1759 1.44E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 6964 7178 7.01E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 9305 9321 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 9138 9507 3.7E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 9144 9570 1.2E-226 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 16 438 4.0E-180 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 7590 8017 1.6E-219 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 2526 2953 1.9E-230 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 3851 4277 2.2E-228 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 6006 6433 3.4E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 1038 1465 7.4E-230 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SMART SM00825 Beta-ketoacyl synthase 10936 11363 1.5E-229 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 4571 4670 8.11E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF52151 4383 4507 8.11E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF55048 11593 11657 6.54E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF53901 7585 7961 8.08E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 SUPERFAMILY SSF51735 7189 7425 2.22E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04360 cc048c3eae8c09e021384d041e07a72e 12561 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2688 2704 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 Pfam PF00005 ABC transporter 393 540 1.1E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 SUPERFAMILY SSF52540 369 610 7.69E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 SUPERFAMILY SSF90123 27 345 1.18E-69 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 Gene3D G3DSA:1.20.1560.10 27 345 6.1E-68 T 17-03-2017 SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 Gene3D G3DSA:3.40.50.300 373 604 3.1E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 Pfam PF00664 ABC transporter transmembrane region 45 310 1.6E-37 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 SMART SM00382 402 581 2.0E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35845 2065e9997ac7fd0f249eaaab91141a58 620 ProSitePatterns PS00211 ABC transporters family signature. 513 527 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 Pfam PF13699 Domain of unknown function (DUF4157) 44 119 4.6E-25 T 17-03-2017 IPR025295 Domain of unknown function DUF4157 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 PRINTS PR01217 Proline rich extensin signature 1663 1675 7.6E-9 T 17-03-2017 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 PRINTS PR01217 Proline rich extensin signature 1621 1633 7.6E-9 T 17-03-2017 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 PRINTS PR01217 Proline rich extensin signature 1699 1715 7.6E-9 T 17-03-2017 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 PRINTS PR01217 Proline rich extensin signature 1641 1657 7.6E-9 T 17-03-2017 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 PRINTS PR01217 Proline rich extensin signature 1761 1786 7.6E-9 T 17-03-2017 SHXM_RS05830 884e571b59d09fab286db4366affe1bd 2079 PRINTS PR01217 Proline rich extensin signature 1677 1698 7.6E-9 T 17-03-2017 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 Pfam PF00162 Phosphoglycerate kinase 4 390 5.4E-149 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 Gene3D G3DSA:3.40.50.1270 182 388 4.4E-78 T 17-03-2017 IPR015901 Phosphoglycerate kinase, C-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PIRSF PIRSF000724 1 400 1.4E-135 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 SUPERFAMILY SSF53748 2 400 1.88E-144 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 Hamap MF_00145 Phosphoglycerate kinase [pgk]. 3 400 41.179 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 29 51 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 139 161 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 107 122 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 192 211 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 376 393 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 319 344 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 8 24 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 352 363 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 PRINTS PR00477 Phosphoglycerate kinase family signature 169 191 3.4E-82 T 17-03-2017 IPR001576 Phosphoglycerate kinase GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 Gene3D G3DSA:3.40.50.1260 2 181 1.2E-68 T 17-03-2017 IPR015824 Phosphoglycerate kinase, N-terminal GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17920 f8c66e5eb96fd95975f00267c4266d47 400 ProSitePatterns PS00111 Phosphoglycerate kinase signature. 13 23 - T 17-03-2017 IPR015911 Phosphoglycerate kinase, conserved site GO:0004618|GO:0006096 KEGG: 00010+2.7.2.3|KEGG: 00710+2.7.2.3|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 Pfam PF00106 short chain dehydrogenase 5 189 6.1E-51 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4 190 1.9E-4 T 17-03-2017 SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 129 137 3.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 3.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 76 87 3.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 SUPERFAMILY SSF51735 2 238 1.24E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 Gene3D G3DSA:3.40.50.720 3 238 9.5E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 4.9E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 4.9E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 4.9E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 4.9E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41815 a7e623c409a5fcc9b9d9d8bf9f7f0d96 291 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 4.9E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 843 857 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 1106 1120 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 PRINTS PR00320 G protein beta WD-40 repeat signature 889 903 1.6E-8 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 PRINTS PR00320 G protein beta WD-40 repeat signature 1198 1212 1.6E-8 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 PRINTS PR00320 G protein beta WD-40 repeat signature 752 766 1.6E-8 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF13191 AAA ATPase domain 156 314 4.9E-9 T 17-03-2017 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Gene3D G3DSA:2.130.10.10 1093 1306 1.2E-54 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Gene3D G3DSA:3.40.50.300 150 300 1.9E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 1198 1212 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 706 720 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Gene3D G3DSA:2.130.10.10 686 768 2.9E-27 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Gene3D G3DSA:2.130.10.10 779 1077 3.4E-85 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 1264 1303 32.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 772 811 1.4E-6 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 909 948 7.7E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 680 719 8.6E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 817 856 1.0E-11 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 1126 1165 7.6E-10 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 726 765 3.5E-11 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 1034 1073 2.5 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 1218 1257 1.6E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 1172 1211 6.0E-10 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 955 994 4.0E-6 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 997 1027 23.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 1080 1119 0.0018 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SMART SM00320 863 902 4.2E-11 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SUPERFAMILY SSF50998 1067 1171 2.98E-86 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SUPERFAMILY SSF50998 690 1001 2.98E-86 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SUPERFAMILY SSF52540 154 392 4.45E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 798 812 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 752 766 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 1244 1258 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 914 948 7.0E-7 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 820 856 1.5E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 970 994 4.7E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 779 811 2.1E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 1224 1257 5.4E-7 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 1131 1165 1.2E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 868 902 2.4E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 1179 1211 1.9E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 1096 1119 0.0083 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 731 765 9.1E-9 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 Pfam PF00400 WD domain, G-beta repeat 687 719 1.2E-5 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 935 949 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 1014 1028 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 889 903 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS26060 6b6b6501a9724a6704112a2248e9028d 1341 SUPERFAMILY SSF101908 1010 1307 3.27E-62 T 17-03-2017 SHXM_RS41980 521aba9615b856f0247d7dba4c58c0bc 346 SUPERFAMILY SSF53807 57 339 1.61E-39 T 17-03-2017 SHXM_RS41980 521aba9615b856f0247d7dba4c58c0bc 346 Pfam PF01497 Periplasmic binding protein 62 317 2.7E-37 T 17-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SHXM_RS41980 521aba9615b856f0247d7dba4c58c0bc 346 Gene3D G3DSA:3.40.50.1980 57 202 1.2E-13 T 17-03-2017 SHXM_RS41980 521aba9615b856f0247d7dba4c58c0bc 346 Gene3D G3DSA:3.40.50.1980 214 339 1.6E-25 T 17-03-2017 SHXM_RS50530 347cabde21940243016016bf5a9d7eaa 33 Gene3D G3DSA:1.10.10.60 4 32 2.0E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50530 347cabde21940243016016bf5a9d7eaa 33 SUPERFAMILY SSF46689 1 33 2.69E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50530 347cabde21940243016016bf5a9d7eaa 33 Pfam PF01527 Transposase 1 33 1.4E-9 T 17-03-2017 IPR002514 Transposase IS3/IS911family GO:0003677|GO:0004803|GO:0006313 SHXM_RS06150 d59b750fc6fa6a00045ab861670553e2 126 TIGRFAM TIGR03889 nitrile_acc: nitrile hydratase accessory protein 22 91 1.6E-23 T 17-03-2017 IPR023808 Nitrile hydratase accessory protein, putative SHXM_RS06150 d59b750fc6fa6a00045ab861670553e2 126 SUPERFAMILY SSF50090 9 114 1.29E-20 T 17-03-2017 IPR008990 Electron transport accessory protein-like domain SHXM_RS06150 d59b750fc6fa6a00045ab861670553e2 126 Gene3D G3DSA:1.10.472.20 9 112 2.2E-19 T 17-03-2017 SHXM_RS06150 d59b750fc6fa6a00045ab861670553e2 126 Pfam PF02211 Nitrile hydratase beta subunit 17 109 3.2E-10 T 17-03-2017 IPR024690 Nitrile hydratase beta subunit domain GO:0018822 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS31875 f08e9440f1b5f6939842c13211ddaf8e 483 Gene3D G3DSA:3.20.20.140 162 349 6.2E-20 T 17-03-2017 SHXM_RS31875 f08e9440f1b5f6939842c13211ddaf8e 483 SUPERFAMILY SSF89550 162 368 1.44E-35 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS31875 f08e9440f1b5f6939842c13211ddaf8e 483 SMART SM00481 165 229 1.1E-5 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 Gene3D G3DSA:3.40.47.10 288 403 6.4E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 Gene3D G3DSA:3.40.47.10 148 186 6.4E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 SUPERFAMILY SSF53901 3 277 1.33E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 7 402 6.8E-132 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 ProSitePatterns PS00737 Thiolases signature 2. 350 366 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 PIRSF PIRSF000429 2 404 3.4E-108 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 Pfam PF02803 Thiolase, C-terminal domain 282 403 1.3E-47 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 ProSitePatterns PS00099 Thiolases active site. 385 398 - T 17-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 SUPERFAMILY SSF53901 282 403 2.02E-45 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 Gene3D G3DSA:3.40.47.10 187 287 9.2E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 Gene3D G3DSA:3.40.47.10 5 128 9.2E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13530 4561d92301651c5825e50d46a9d4bb99 404 Pfam PF00108 Thiolase, N-terminal domain 7 230 3.8E-42 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF50129 4547 4686 8.18E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 522 745 4.46E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3333 3349 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.980 10 175 2.6E-35 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 2297 2467 1.73E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1103 1353 1.7E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5242 5492 4.7E-86 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3170 3420 2.2E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 4859 5042 2.4E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF53901 3165 3541 1.92E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 2506 2560 9.9E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 4572 4625 1.9E-4 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 5500 5616 3.3E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1361 1478 5.7E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3428 3543 1.1E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.366.10 5971 6094 2.6E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.366.10 3703 3835 8.1E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.366.10 1831 1955 4.0E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.366.10 3905 4028 8.1E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.366.10 1632 1764 4.0E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.366.10 5770 5902 2.6E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6715 6730 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF52151 3906 4001 1.57E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF52151 3711 3840 1.57E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF13602 Zinc-binding dehydrogenase 2667 2786 3.0E-15 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF13602 Zinc-binding dehydrogenase 4739 4850 2.3E-15 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF50129 2482 2622 3.3E-25 T 17-03-2017 IPR011032 GroES-like SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 2793 3042 1.06E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1266 1282 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 759 926 3.1E-8 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6405 6585 1.1E-46 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4860 5040 7.3E-57 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2796 2976 4.7E-59 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.47.10 1100 1365 1.5E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF14765 Polyketide synthase dehydratase 2009 2286 4.8E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF14765 Polyketide synthase dehydratase 4082 4355 1.1E-51 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00455 Putative AMP-binding domain signature. 170 181 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:1.10.1200.10 6687 6761 2.8E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:1.10.1200.10 1010 1086 5.3E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:1.10.1200.10 5141 5216 7.0E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:1.10.1200.10 3074 3151 4.5E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 4363 4533 5.31E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1644 1942 4.1E-116 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3715 4015 1.1E-106 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5782 6081 2.4E-123 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.980 176 329 1.1E-34 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00501 AMP-binding enzyme 15 417 2.6E-102 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 6403 6639 3.78E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF47336 6682 6764 5.5E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00825 Beta-ketoacyl synthase 5244 5670 3.7E-212 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00825 Beta-ketoacyl synthase 3172 3598 2.3E-218 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00825 Beta-ketoacyl synthase 1105 1531 1.8E-218 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 2613 2634 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.30.70.250 5906 5970 7.1E-9 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.30.70.250 1768 1830 1.2E-4 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.30.70.250 3839 3897 1.5E-4 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 5620 5744 1.6E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1481 1606 5.4E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3548 3675 5.9E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.90.180.10 4548 4682 8.0E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.90.180.10 2483 2619 6.4E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00829 2486 2786 4.8E-171 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00829 4552 4850 5.2E-168 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF08659 KR domain 4860 5039 9.7E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF08659 KR domain 759 922 2.7E-17 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF08659 KR domain 2796 2975 3.0E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF08659 KR domain 6406 6583 1.1E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:2.30.38.10 334 408 1.0E-28 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF56801 7 511 2.62E-149 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 4649 4821 1.07E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.720 6406 6587 2.4E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.720 2795 2978 5.0E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.720 4860 5038 2.6E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00823 Phosphopantetheine attachment site 3078 3150 1.4E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00823 Phosphopantetheine attachment site 1013 1085 8.8E-27 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00823 Phosphopantetheine attachment site 6689 6760 4.2E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00823 Phosphopantetheine attachment site 5144 5216 8.7E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM01294 5145 5212 5.7E-6 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM01294 6690 6756 4.0E-4 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM01294 3083 3146 8.0E-5 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM01294 1014 1081 4.5E-4 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF53901 5239 5615 2.82E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF47336 5141 5256 4.19E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.47.10 1366 1530 1.6E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.47.10 3433 3599 9.5E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.47.10 5505 5670 1.5E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF52151 1832 1930 1.44E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF52151 1640 1769 1.44E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF52151 5778 5907 2.09E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF52151 5972 6070 2.09E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5171 5186 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.47.10 5244 5504 3.1E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.47.10 3172 3432 1.6E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.720 758 925 1.0E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.720 4683 4771 1.4E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.40.50.720 2620 2706 5.1E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 757 931 2.4E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF53901 1101 1475 1.22E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF13193 AMP-binding enzyme C-terminal domain 426 500 1.1E-18 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00698 Acyl transferase domain 1642 1959 2.3E-78 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00698 Acyl transferase domain 5780 6099 3.5E-85 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00698 Acyl transferase domain 3713 4033 1.7E-80 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF55048 3839 3899 1.44E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 5405 5421 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF47336 3073 3185 2.22E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF55048 1768 1831 1.07E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3105 3120 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 6185 6394 1.61E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF47336 1012 1117 1.07E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00550 Phosphopantetheine attachment site 3081 3144 2.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00550 Phosphopantetheine attachment site 1016 1081 7.1E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00550 Phosphopantetheine attachment site 6692 6756 1.6E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Pfam PF00550 Phosphopantetheine attachment site 5147 5212 4.5E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00826 2009 2175 1.6E-75 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SMART SM00826 4082 4242 1.6E-75 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 Gene3D G3DSA:3.30.300.30 412 508 2.7E-26 T 17-03-2017 SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF51735 2585 2757 2.61E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42870 0630ecd081e4ba7cb84a8e4dde01881e 6842 SUPERFAMILY SSF55048 5906 5971 1.57E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 SUPERFAMILY SSF52151 203 319 4.71E-58 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 SUPERFAMILY SSF52151 18 135 4.71E-58 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 Pfam PF00698 Acyl transferase domain 21 311 4.2E-37 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS23070 d448750b76b3a81483065241455b7086 350 SUPERFAMILY SSF55048 142 209 2.22E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 21 320 1.3E-44 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS23070 d448750b76b3a81483065241455b7086 350 Gene3D G3DSA:3.40.366.10 210 312 3.6E-58 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 Gene3D G3DSA:3.40.366.10 14 135 3.6E-58 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 Gene3D G3DSA:3.30.70.250 140 209 4.5E-18 T 17-03-2017 SHXM_RS23070 d448750b76b3a81483065241455b7086 350 PIRSF PIRSF000446 16 322 1.5E-66 T 17-03-2017 IPR024925 Malonyl CoA-acyl carrier protein transacylase KEGG: 00061+2.3.1.39|MetaCyc: PWY-4381|MetaCyc: PWY-6799|MetaCyc: PWY-7388 SHXM_RS30920 a2b2c58f65eec111bea2feca6976f336 410 Pfam PF07730 Histidine kinase 208 272 2.4E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS30920 a2b2c58f65eec111bea2feca6976f336 410 SUPERFAMILY SSF55874 285 394 5.07E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30920 a2b2c58f65eec111bea2feca6976f336 410 Gene3D G3DSA:3.30.565.10 313 396 3.5E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30920 a2b2c58f65eec111bea2feca6976f336 410 Pfam PF13796 Putative sensor 40 157 6.9E-28 T 17-03-2017 IPR025828 Putative sensor domain SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 Gene3D G3DSA:1.10.10.10 5 69 8.6E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 Gene3D G3DSA:3.30.450.40 79 255 2.8E-57 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 SUPERFAMILY SSF55781 71 254 1.45E-51 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 Pfam PF09339 IclR helix-turn-helix domain 7 58 3.6E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 SUPERFAMILY SSF46785 5 80 3.96E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 SMART SM00346 5 96 2.9E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS20470 93e67076d8576b748dc82862e2248c25 258 Pfam PF01614 Bacterial transcriptional regulator 124 248 1.3E-34 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 SUPERFAMILY SSF56801 9 511 8.37E-109 T 17-03-2017 SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 Pfam PF00501 AMP-binding enzyme 18 416 5.7E-66 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 Gene3D G3DSA:3.30.300.30 412 509 1.5E-21 T 17-03-2017 SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 Pfam PF13193 AMP-binding enzyme C-terminal domain 426 500 2.3E-14 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 ProSitePatterns PS00455 Putative AMP-binding domain signature. 175 186 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 Gene3D G3DSA:3.40.50.980 10 180 5.5E-16 T 17-03-2017 SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 Gene3D G3DSA:2.30.38.10 339 406 3.4E-22 T 17-03-2017 SHXM_RS04380 0cfc696b05882982c09133ffb4702540 513 Gene3D G3DSA:3.40.50.980 181 327 1.8E-29 T 17-03-2017 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 SMART SM01217 676 747 2.4E-25 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 404 634 1.4E-56 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 Gene3D G3DSA:3.40.50.1700 390 637 6.1E-74 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 56 367 3.4E-72 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 288 305 - T 17-03-2017 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 PRINTS PR00133 Glycosyl hydrolase family 3 signature 135 154 3.5E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 PRINTS PR00133 Glycosyl hydrolase family 3 signature 218 234 3.5E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 PRINTS PR00133 Glycosyl hydrolase family 3 signature 181 197 3.5E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 PRINTS PR00133 Glycosyl hydrolase family 3 signature 116 132 3.5E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 PRINTS PR00133 Glycosyl hydrolase family 3 signature 288 306 3.5E-18 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 Pfam PF14310 Fibronectin type III-like domain 676 747 1.2E-18 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 SUPERFAMILY SSF51445 40 401 2.32E-102 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 SUPERFAMILY SSF52279 404 637 1.44E-57 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS06815 a7f91ca4f54ab4d91e88e4dc2683eb8e 758 Gene3D G3DSA:3.20.20.300 42 383 5.4E-108 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 277 457 7.7E-36 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 Gene3D G3DSA:3.30.420.40 272 500 1.7E-52 T 17-03-2017 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 6 265 5.3E-38 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 SUPERFAMILY SSF53067 6 270 8.05E-50 T 17-03-2017 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 Gene3D G3DSA:3.30.420.40 3 265 2.0E-48 T 17-03-2017 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 372 392 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 SUPERFAMILY SSF53067 274 497 8.6E-57 T 17-03-2017 SHXM_RS10745 ee292dd9c6ac889f83ee2fd4253d60fc 512 PIRSF PIRSF000538 3 508 5.9E-113 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 SUPERFAMILY SSF51230 511 582 1.03E-19 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 SMART SM00878 333 441 2.0E-56 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Pfam PF02785 Biotin carboxylase C-terminal domain 333 441 3.7E-36 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Gene3D G3DSA:3.30.470.20 202 446 8.6E-90 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Gene3D G3DSA:2.40.50.100 512 583 1.6E-22 T 17-03-2017 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Pfam PF00364 Biotin-requiring enzyme 517 582 8.8E-17 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 SUPERFAMILY SSF56059 114 321 1.22E-58 T 17-03-2017 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 539 556 - T 17-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Gene3D G3DSA:3.30.1490.20 129 201 3.5E-21 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Pfam PF00289 Biotin carboxylase, N-terminal domain 2 109 1.4E-43 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 285 292 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 SUPERFAMILY SSF51246 328 444 1.26E-36 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 114 319 3.8E-75 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 Gene3D G3DSA:3.40.50.20 2 128 2.7E-49 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS23035 39530057791a83e77dcf704deac97e98 584 SUPERFAMILY SSF52440 2 112 7.91E-46 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 PIRSF PIRSF002181 2 147 2.4E-49 T 17-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 Pfam PF00572 Ribosomal protein L13 14 137 5.2E-58 T 17-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 SUPERFAMILY SSF52161 5 144 8.63E-61 T 17-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 Gene3D G3DSA:3.90.1180.10 3 141 1.1E-64 T 17-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 ProSitePatterns PS00783 Ribosomal protein L13 signature. 105 127 - T 17-03-2017 IPR023563 Ribosomal protein L13, conserved site GO:0003735|GO:0005840|GO:0006412 SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 TIGRFAM TIGR01066 rplM_bact: ribosomal protein uL13 7 141 9.0E-62 T 17-03-2017 IPR005823 Ribosomal protein L13, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31370 f00f5e764f6415f93ae7b21730ce1253 147 Hamap MF_01366 50S ribosomal protein L13 [rplM]. 15 146 28.555 T 17-03-2017 IPR005822 Ribosomal protein L13 GO:0003735|GO:0005840|GO:0006412 SHXM_RS20785 745bc366011e47c8335b9b36abca9d41 120 SUPERFAMILY SSF48498 5 117 2.33E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS20785 745bc366011e47c8335b9b36abca9d41 120 Gene3D G3DSA:1.10.357.10 11 117 6.5E-13 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 Gene3D G3DSA:1.10.540.10 8 120 2.0E-37 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 Gene3D G3DSA:2.40.110.10 123 218 2.7E-32 T 17-03-2017 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 SUPERFAMILY SSF47203 231 383 9.5E-53 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 125 137 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 232 380 3.2E-45 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 124 218 1.5E-24 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 Gene3D G3DSA:1.20.140.10 219 383 4.4E-62 T 17-03-2017 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 8 119 1.1E-32 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS05520 e772bd96300f398f80726682410ac8b7 387 SUPERFAMILY SSF56645 7 244 7.2E-72 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 Pfam PF12802 MarR family 82 141 6.5E-12 T 17-03-2017 SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 PRINTS PR00598 Bacterial regulatory protein MarR family signature 168 188 3.2E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 PRINTS PR00598 Bacterial regulatory protein MarR family signature 138 154 3.2E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 PRINTS PR00598 Bacterial regulatory protein MarR family signature 119 134 3.2E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 Gene3D G3DSA:1.10.10.10 80 191 9.5E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 SMART SM00347 74 178 1.5E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS03860 111e0ff5e0fd2480e57528ee00c627ba 214 SUPERFAMILY SSF46785 80 190 1.63E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 SUPERFAMILY SSF51366 9 278 2.59E-61 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 Pfam PF00215 Orotidine 5'-phosphate decarboxylase / HUMPS family 22 269 1.1E-37 T 17-03-2017 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 Hamap MF_01215 Orotidine 5'-phosphate decarboxylase [pyrF]. 7 284 33.335 T 17-03-2017 IPR011995 Orotidine 5'-phosphate decarboxylase, type 2 GO:0004590|GO:0006221 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686 SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 ProSitePatterns PS00156 Orotidine 5'-phosphate decarboxylase active site. 96 109 - T 17-03-2017 IPR018089 Orotidine 5'-phosphate decarboxylase, active site GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 Gene3D G3DSA:3.20.20.70 11 280 2.6E-59 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 SMART SM00934 22 274 4.8E-27 T 17-03-2017 IPR001754 Orotidine 5'-phosphate decarboxylase domain GO:0004590|GO:0006207 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12345 4afc499aa092540d7314989041ab1353 287 TIGRFAM TIGR02127 pyrF_sub2: orotidine 5'-phosphate decarboxylase 9 274 2.7E-82 T 17-03-2017 IPR011995 Orotidine 5'-phosphate decarboxylase, type 2 GO:0004590|GO:0006221 KEGG: 00240+4.1.1.23|MetaCyc: PWY-5686 SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 2.1E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 2.1E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 SUPERFAMILY SSF51735 4 224 1.37E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 Gene3D G3DSA:3.40.50.720 2 225 6.8E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 3.1E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 190 210 3.1E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 3.1E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 3.1E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 3.1E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 116 132 3.1E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38695 a604348f1f4bfd35d036e13c781e0b4a 228 Pfam PF00106 short chain dehydrogenase 3 190 1.7E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS36755 8ffe9025e86e2444ca3404b0c4735640 340 Gene3D G3DSA:3.20.20.140 7 334 5.1E-98 T 17-03-2017 SHXM_RS36755 8ffe9025e86e2444ca3404b0c4735640 340 SUPERFAMILY SSF51556 6 335 2.38E-80 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS36755 8ffe9025e86e2444ca3404b0c4735640 340 Pfam PF00962 Adenosine/AMP deaminase 11 328 1.9E-91 T 17-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 SHXM_RS36755 8ffe9025e86e2444ca3404b0c4735640 340 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 11 330 4.3E-85 T 17-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 SHXM_RS32740 ebb242547d37579c5ca25c44a5d559fb 278 Gene3D G3DSA:1.10.150.290 200 257 6.8E-27 T 17-03-2017 IPR023149 Trans-aconitate 2-methyltransferase, C-terminal GO:0030798 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS32740 ebb242547d37579c5ca25c44a5d559fb 278 SUPERFAMILY SSF53335 5 252 1.52E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS32740 ebb242547d37579c5ca25c44a5d559fb 278 Pfam PF13649 Methyltransferase domain 47 142 5.0E-14 T 17-03-2017 SHXM_RS32740 ebb242547d37579c5ca25c44a5d559fb 278 Gene3D G3DSA:3.40.50.150 7 198 1.2E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS32740 ebb242547d37579c5ca25c44a5d559fb 278 Hamap MF_00560 Trans-aconitate 2-methyltransferase [tam]. 5 276 43.475 T 17-03-2017 IPR023506 Trans-aconitate 2-methyltransferase GO:0030798 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS33030 1ff304376d48e9effd9fcb6c2a0f3f48 379 Gene3D G3DSA:3.40.50.2300 76 199 6.5E-18 T 17-03-2017 SHXM_RS33030 1ff304376d48e9effd9fcb6c2a0f3f48 379 Gene3D G3DSA:3.40.50.2300 200 349 1.2E-7 T 17-03-2017 SHXM_RS33030 1ff304376d48e9effd9fcb6c2a0f3f48 379 Pfam PF13407 Periplasmic binding protein domain 77 333 1.8E-22 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS33030 1ff304376d48e9effd9fcb6c2a0f3f48 379 SUPERFAMILY SSF53822 75 353 3.14E-28 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Pfam PF02805 Metal binding domain of Ada 8 71 2.8E-28 T 17-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Gene3D G3DSA:1.10.340.30 317 431 1.8E-33 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SUPERFAMILY SSF46689 137 186 1.16E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 137 179 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SMART SM01009 199 314 2.0E-43 T 17-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Gene3D G3DSA:3.30.310.20 199 314 3.1E-33 T 17-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SUPERFAMILY SSF57884 2 83 1.27E-31 T 17-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Pfam PF06029 AlkA N-terminal domain 199 314 2.0E-28 T 17-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 320 454 9.1E-5 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SUPERFAMILY SSF48150 303 479 2.79E-39 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SMART SM00478 324 481 1.2E-30 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Gene3D G3DSA:1.10.1670.10 432 480 6.6E-16 T 17-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Gene3D G3DSA:1.10.10.60 137 186 4.2E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SUPERFAMILY SSF55945 199 294 1.88E-24 T 17-03-2017 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 SMART SM00342 100 183 5.9E-17 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Pfam PF12833 Helix-turn-helix domain 106 185 2.9E-17 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS14805 db2dd331b360f7b126d923c7c8b9e0f5 491 Gene3D G3DSA:3.40.10.10 2 83 2.7E-34 T 17-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 SMART SM00382 113 333 3.6E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Hamap MF_00175 ATP-dependent Clp protease ATP-binding subunit ClpX [clpX]. 2 415 52.563 T 17-03-2017 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 TIGRFAM TIGR00382 clpX: ATP-dependent Clp protease, ATP-binding subunit ClpX 9 411 2.9E-197 T 17-03-2017 IPR004487 Clp protease, ATP-binding subunit ClpX GO:0005524|GO:0006457|GO:0051082 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Pfam PF06689 ClpX C4-type zinc finger 11 48 8.9E-21 T 17-03-2017 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 SUPERFAMILY SSF57716 11 46 1.37E-11 T 17-03-2017 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 317 394 1.3E-15 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 SUPERFAMILY SSF52540 58 402 6.04E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Gene3D G3DSA:3.40.50.300 294 311 4.0E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Gene3D G3DSA:3.40.50.300 62 255 4.0E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 SMART SM01086 317 411 3.2E-30 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Gene3D G3DSA:1.10.8.60 316 412 4.5E-34 T 17-03-2017 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 SMART SM00994 10 49 1.1E-23 T 17-03-2017 IPR010603 Zinc finger, ClpX C4-type GO:0008270|GO:0046983 SHXM_RS21695 d04d513c913bf2db8e57d938a0990085 428 Pfam PF07724 AAA domain (Cdc48 subfamily) 114 311 1.9E-51 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS28210 b819bfd3f449fcf5ca2f8dfb8177ad72 294 SUPERFAMILY SSF144091 79 265 1.31E-45 T 17-03-2017 SHXM_RS28210 b819bfd3f449fcf5ca2f8dfb8177ad72 294 Pfam PF01694 Rhomboid family 126 260 4.4E-38 T 17-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SHXM_RS28210 b819bfd3f449fcf5ca2f8dfb8177ad72 294 Gene3D G3DSA:1.20.1540.10 81 257 5.7E-43 T 17-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 SUPERFAMILY SSF51735 4 161 6.94E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 Gene3D G3DSA:3.30.360.10 151 288 2.3E-46 T 17-03-2017 SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 Gene3D G3DSA:3.30.360.10 335 382 2.3E-46 T 17-03-2017 SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 144 275 2.5E-13 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 6 132 4.8E-25 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 Gene3D G3DSA:3.40.50.720 3 150 1.5E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04525 1c0e24bc1fc7cb42ae57afd163f3d77a 384 SUPERFAMILY SSF55347 138 328 6.05E-37 T 17-03-2017 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 Gene3D G3DSA:2.40.110.10 112 203 5.5E-29 T 17-03-2017 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 Gene3D G3DSA:1.20.140.10 204 366 9.7E-36 T 17-03-2017 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 17 109 4.2E-11 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 221 362 3.7E-29 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 Gene3D G3DSA:1.10.540.10 12 109 5.7E-21 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 SUPERFAMILY SSF56645 11 214 2.36E-50 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 SUPERFAMILY SSF47203 222 364 1.39E-31 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS42830 8b70c1c48b7d0cf81e39264f4d7d7b0e 370 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 112 202 1.4E-18 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 SUPERFAMILY SSF51182 69 181 1.3E-21 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 SMART SM00530 16 71 6.0E-17 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 SUPERFAMILY SSF47413 6 76 6.48E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 Pfam PF01381 Helix-turn-helix 17 71 5.3E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 Pfam PF07883 Cupin domain 117 182 8.6E-16 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 Gene3D G3DSA:2.60.120.10 121 181 3.9E-14 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS03490 109cd8ba29cb94a17dcec401b547c047 198 Gene3D G3DSA:1.10.260.40 9 83 1.5E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 Pfam PF00106 short chain dehydrogenase 4 191 2.0E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 128 136 3.1E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 3.1E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 3.1E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 SUPERFAMILY SSF51735 3 242 3.38E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 3.9E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 122 138 3.9E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 3.9E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 3.9E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 3.9E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41865 900c7dcb3d7fc325cba409e0b658e1fc 270 Gene3D G3DSA:3.40.50.720 3 240 2.0E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 SUPERFAMILY SSF47413 1 59 2.72E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 Gene3D G3DSA:3.40.50.2300 169 297 9.1E-30 T 17-03-2017 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 SUPERFAMILY SSF53822 59 316 1.51E-50 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 Pfam PF13377 Periplasmic binding protein-like domain 165 322 3.0E-26 T 17-03-2017 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 48 3.7E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 Gene3D G3DSA:3.40.50.2300 54 168 1.9E-38 T 17-03-2017 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 SMART SM00354 1 71 1.7E-25 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 Gene3D G3DSA:1.10.260.40 3 53 7.7E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12970 bc6a064351f5028b814adb41d799d2ec 329 ProSitePatterns PS00356 LacI-type HTH domain signature. 4 22 - T 17-03-2017 SHXM_RS22295 c5d3568a1e29b4e772f27d695b934fad 796 SUPERFAMILY SSF82866 507 719 7.59E-24 T 17-03-2017 SHXM_RS22295 c5d3568a1e29b4e772f27d695b934fad 796 SUPERFAMILY SSF82866 160 345 1.96E-27 T 17-03-2017 SHXM_RS22295 c5d3568a1e29b4e772f27d695b934fad 796 Gene3D G3DSA:1.20.1640.10 507 724 1.4E-27 T 17-03-2017 SHXM_RS22295 c5d3568a1e29b4e772f27d695b934fad 796 Gene3D G3DSA:1.20.1640.10 146 346 4.0E-28 T 17-03-2017 SHXM_RS22295 c5d3568a1e29b4e772f27d695b934fad 796 Pfam PF03176 MMPL family 412 722 1.7E-35 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS22295 c5d3568a1e29b4e772f27d695b934fad 796 Pfam PF03176 MMPL family 54 379 9.3E-44 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 263 317 - T 17-03-2017 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 Gene3D G3DSA:1.20.210.10 26 554 7.5E-196 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 43 485 1.2E-145 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 SUPERFAMILY SSF81442 30 541 1.01E-176 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 TIGRFAM TIGR02891 CtaD_CoxA: cytochrome c oxidase, subunit I 34 538 5.4E-214 T 17-03-2017 IPR014241 Cytochrome c oxidase, subunit I bacterial type GO:0004129|GO:0005507|GO:0005886|GO:0006810|GO:0022900|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 80 103 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 211 230 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 182 200 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 329 350 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 307 322 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 261 282 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 392 411 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 107 131 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 33 58 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 364 382 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 240 261 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 442 463 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18905 26346424fc6a2ab1c4a9357175cac70a 579 PRINTS PR01165 Cytochrome c oxidase subunit I signature 150 162 6.3E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 TIGRFAM TIGR00472 pheT_bact: phenylalanine--tRNA ligase, beta subunit 1 839 9.7E-192 T 17-03-2017 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SUPERFAMILY SSF46955 421 491 3.3E-15 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SUPERFAMILY SSF55681 483 599 6.46E-42 T 17-03-2017 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SUPERFAMILY SSF55681 629 732 6.46E-42 T 17-03-2017 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SUPERFAMILY SSF50249 45 204 8.57E-35 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SMART SM00874 420 487 3.4E-23 T 17-03-2017 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Pfam PF03483 B3/4 domain 220 404 5.2E-68 T 17-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SUPERFAMILY SSF54991 743 839 9.29E-26 T 17-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:3.30.930.10 502 733 5.8E-61 T 17-03-2017 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SMART SM00873 220 404 5.9E-83 T 17-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SUPERFAMILY SSF56037 205 409 3.66E-64 T 17-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Pfam PF03484 tRNA synthetase B5 domain 422 487 1.0E-17 T 17-03-2017 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:3.30.56.10 1 40 6.3E-18 T 17-03-2017 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:3.30.56.10 163 191 6.3E-18 T 17-03-2017 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Pfam PF01588 Putative tRNA binding domain 48 153 6.0E-21 T 17-03-2017 IPR002547 tRNA-binding domain GO:0000049 Reactome: R-HSA-379716 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:3.30.70.380 748 839 2.0E-29 T 17-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:3.50.40.10 208 413 4.5E-83 T 17-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Pfam PF03147 Ferredoxin-fold anticodon binding domain 746 839 1.6E-24 T 17-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:2.40.50.140 46 161 9.6E-42 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Gene3D G3DSA:3.30.56.20 420 491 7.1E-23 T 17-03-2017 IPR005147 tRNA synthetase, B5-domain GO:0000287|GO:0003723|GO:0005524|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 SMART SM00896 746 839 3.5E-41 T 17-03-2017 IPR005121 Phenylalanine-tRNA ligase, beta subunit, ferrodoxin-fold anticodon-binding GO:0000049|GO:0000287|GO:0004826|GO:0005524|GO:0006432|GO:0008033 KEGG: 00970+6.1.1.20 SHXM_RS13115 ae7bef6335f465a0bec173994dca8e2c 841 Hamap MF_00283 Phenylalanine--tRNA ligase beta subunit [pheT]. 1 833 40.964 T 17-03-2017 IPR004532 Phenylalanine-tRNA ligase, class IIc, beta subunit GO:0000287|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00826 2676 2843 4.6E-83 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00826 940 1105 1.2E-78 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.30.70.250 2433 2497 1.6E-7 T 17-03-2017 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.30.70.250 699 763 1.7E-7 T 17-03-2017 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.47.10 39 299 3.2E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.90.180.10 3168 3312 5.6E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:1.10.1200.10 1672 1745 1.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:1.10.1200.10 3780 3856 1.1E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.47.10 1767 2033 6.9E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF53901 1766 2143 3.99E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3810 3825 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 415 529 7.4E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2149 2271 2.3E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF51735 2969 3155 1.97E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1770 2021 3.6E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 37 287 2.1E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF51735 1227 1371 1.46E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF51735 1384 1598 1.97E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF52151 572 700 5.75E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF52151 765 863 5.75E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00550 Phosphopantetheine attachment site 1676 1741 5.9E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00550 Phosphopantetheine attachment site 3786 3851 1.3E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00698 Acyl transferase domain 2308 2626 1.1E-88 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00698 Acyl transferase domain 573 892 6.5E-93 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF53901 34 410 2.58E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00823 Phosphopantetheine attachment site 1673 1745 4.7E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00823 Phosphopantetheine attachment site 3783 3855 1.8E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 3198 3254 3.4E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF55048 699 764 9.16E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 575 873 4.8E-121 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2309 2607 3.3E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.50.720 3313 3406 1.8E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF08659 KR domain 1384 1563 2.1E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF08659 KR domain 3494 3673 1.0E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.47.10 2034 2198 4.1E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.47.10 300 466 1.7E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00829 3179 3484 4.1E-175 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 3306 3327 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM01294 1674 1741 7.7E-5 T 17-03-2017 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM01294 3784 3851 4.7E-6 T 17-03-2017 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF47336 1672 1785 4.19E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF51735 3493 3705 7.87E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF52151 2499 2599 1.07E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF52151 2307 2435 1.07E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1934 1950 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF51735 3278 3455 1.23E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00825 Beta-ketoacyl synthase 39 465 1.1E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00825 Beta-ketoacyl synthase 1772 2199 3.3E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF00107 Zinc-binding dehydrogenase 3317 3408 2.1E-16 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF50129 3184 3311 2.99E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 200 216 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1700 1715 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.366.10 564 695 8.8E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.366.10 2498 2620 7.9E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.366.10 764 887 8.8E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.366.10 2299 2430 7.9E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF55048 2433 2498 1.83E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SUPERFAMILY SSF47336 3777 3861 8.11E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.50.720 1641 1655 1.2E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.50.720 3494 3706 1.7E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Gene3D G3DSA:3.40.50.720 1385 1568 1.2E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF14765 Polyketide synthase dehydratase 2676 2961 2.2E-59 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF14765 Polyketide synthase dehydratase 940 1219 3.8E-52 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 295 412 1.6E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2029 2146 8.7E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3494 3674 3.4E-54 T 17-03-2017 SHXM_RS45345 e539c8005c7844004aa96c0df6dfa792 3952 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1384 1564 2.8E-55 T 17-03-2017 SHXM_RS33500 68d32cbf13a0d0da62645cdbd90440db 134 SUPERFAMILY SSF50249 3 67 2.45E-15 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS33500 68d32cbf13a0d0da62645cdbd90440db 134 Pfam PF00313 'Cold-shock' DNA-binding domain 4 66 1.3E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS33500 68d32cbf13a0d0da62645cdbd90440db 134 Gene3D G3DSA:2.40.50.140 3 70 3.2E-18 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS33500 68d32cbf13a0d0da62645cdbd90440db 134 SMART SM00357 4 67 3.1E-10 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS35425 970ae152059efc6abff12e44f6b4cf6d 236 TIGRFAM TIGR00101 ureG: urease accessory protein UreG 28 220 2.3E-73 T 17-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 SHXM_RS35425 970ae152059efc6abff12e44f6b4cf6d 236 SUPERFAMILY SSF52540 19 222 4.56E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35425 970ae152059efc6abff12e44f6b4cf6d 236 Hamap MF_01389 Urease accessory protein UreG [ureG]. 26 227 41.962 T 17-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 SHXM_RS35425 970ae152059efc6abff12e44f6b4cf6d 236 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 30 203 5.9E-28 T 17-03-2017 IPR003495 CobW/HypB/UreG, nucleotide-binding domain SHXM_RS35425 970ae152059efc6abff12e44f6b4cf6d 236 PIRSF PIRSF005624 10 236 3.4E-48 T 17-03-2017 SHXM_RS35425 970ae152059efc6abff12e44f6b4cf6d 236 Gene3D G3DSA:3.40.50.300 29 220 1.5E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 37 199 2.6E-27 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 Gene3D G3DSA:1.10.10.10 140 202 1.0E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 Pfam PF08281 Sigma-70, region 4 143 196 4.4E-16 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 SUPERFAMILY SSF88946 23 116 9.81E-23 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 Gene3D G3DSA:1.10.1740.10 23 126 2.6E-27 T 17-03-2017 SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 63 94 - T 17-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 SUPERFAMILY SSF88659 121 201 3.92E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25160 1506a22d93c280b8195dbc7dfe0ca4f7 362 Pfam PF04542 Sigma-70 region 2 42 109 1.0E-14 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 SUPERFAMILY SSF51735 1 206 2.0E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 Pfam PF00106 short chain dehydrogenase 7 182 1.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 181 3.5E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 69 80 3.5E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 143 162 3.5E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 3.5E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 117 133 3.5E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 186 0.0064 T 17-03-2017 SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 Gene3D G3DSA:3.40.50.720 2 197 5.4E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 143 162 2.9E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 69 80 2.9E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45590 2c5e3e29fc95d5af5ee7dd395d486655 232 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 123 131 2.9E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.40.50.720 1718 1899 9.8E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF53901 31 406 5.77E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF13602 Zinc-binding dehydrogenase 1578 1708 3.7E-17 T 17-03-2017 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF14765 Polyketide synthase dehydratase 921 1186 1.7E-50 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF00698 Acyl transferase domain 557 873 2.4E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 2.1E-82 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF50129 1416 1535 3.93E-22 T 17-03-2017 IPR011032 GroES-like SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF51735 1502 1679 9.18E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.40.47.10 37 296 3.8E-86 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:1.10.1200.10 1996 2069 3.8E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM00829 1401 1708 1.3E-163 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF00550 Phosphopantetheine attachment site 2000 2063 6.2E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF51735 1200 1376 6.3E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM00825 Beta-ketoacyl synthase 36 459 7.2E-201 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.40.50.720 1536 1630 1.5E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF52151 556 681 7.06E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF52151 746 844 7.06E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2024 2039 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF08659 KR domain 1718 1898 1.9E-52 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 1530 1551 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF47336 1990 2076 3.66E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.30.70.250 680 744 4.2E-7 T 17-03-2017 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.90.180.10 1417 1535 1.3E-35 T 17-03-2017 IPR011032 GroES-like SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.40.366.10 745 854 3.1E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.40.366.10 556 675 3.1E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF08990 Erythronolide synthase docking 3 27 6.5E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF55048 680 745 2.88E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 408 1.5E-40 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM00826 921 1081 1.7E-70 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM00823 Phosphopantetheine attachment site 1998 2069 1.6E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 417 514 3.6E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 559 854 2.6E-114 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM01294 1999 2065 4.0E-5 T 17-03-2017 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 Gene3D G3DSA:3.40.47.10 297 459 2.6E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SUPERFAMILY SSF51735 1714 1941 1.22E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46805 3efb90bcb2515079b4bd57e9aa3e1860 2118 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1718 1899 1.9E-46 T 17-03-2017 SHXM_RS07870 a5ae7456ddd1b0c5d8aa2d88b7a423bb 480 Pfam PF07690 Major Facilitator Superfamily 15 408 6.1E-44 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS07870 a5ae7456ddd1b0c5d8aa2d88b7a423bb 480 SUPERFAMILY SSF103473 6 196 4.05E-60 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS07870 a5ae7456ddd1b0c5d8aa2d88b7a423bb 480 SUPERFAMILY SSF103473 244 458 4.05E-60 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS07870 a5ae7456ddd1b0c5d8aa2d88b7a423bb 480 Gene3D G3DSA:1.20.1250.20 260 458 5.6E-20 T 17-03-2017 SHXM_RS07870 a5ae7456ddd1b0c5d8aa2d88b7a423bb 480 Gene3D G3DSA:1.20.1250.20 10 188 3.5E-29 T 17-03-2017 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 TIGRFAM TIGR02397 dnaX_nterm: DNA polymerase III, subunit gamma and tau 15 373 5.4E-116 T 17-03-2017 IPR012763 DNA polymerase III, subunit gamma/ tau GO:0003887|GO:0005524|GO:0006260|GO:0009360 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 SMART SM00382 47 191 4.6E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 Pfam PF12169 DNA polymerase III subunits gamma and tau domain III 246 375 2.8E-12 T 17-03-2017 IPR022754 DNA polymerase III, gamma subunit, domain III GO:0003887 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 SUPERFAMILY SSF52540 42 232 1.06E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 Pfam PF13177 DNA polymerase III, delta subunit 30 188 9.9E-38 T 17-03-2017 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 SUPERFAMILY SSF48019 257 375 1.19E-20 T 17-03-2017 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 Gene3D G3DSA:1.20.272.10 256 374 1.5E-13 T 17-03-2017 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 Gene3D G3DSA:1.10.8.60 178 255 1.0E-19 T 17-03-2017 SHXM_RS27160 2900e82bab05726b653eea26079c54bf 869 Gene3D G3DSA:3.40.50.300 25 177 6.0E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48600 abf7c6ede17eb63d0ccd4605b37b7c08 501 SUPERFAMILY SSF51569 22 304 2.2E-45 T 17-03-2017 SHXM_RS48600 abf7c6ede17eb63d0ccd4605b37b7c08 501 Gene3D G3DSA:3.20.20.70 20 297 1.4E-52 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48600 abf7c6ede17eb63d0ccd4605b37b7c08 501 SUPERFAMILY SSF89000 321 458 5.1E-28 T 17-03-2017 SHXM_RS48600 abf7c6ede17eb63d0ccd4605b37b7c08 501 Pfam PF00682 HMGL-like 25 290 3.7E-15 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS48600 abf7c6ede17eb63d0ccd4605b37b7c08 501 Pfam PF02436 Conserved carboxylase domain 318 452 1.2E-22 T 17-03-2017 IPR003379 Carboxylase, conserved domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599|Reactome: R-HSA-70263 SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 Gene3D G3DSA:3.40.50.720 5 272 5.4E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8 202 7.1E-4 T 17-03-2017 SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 SUPERFAMILY SSF51735 6 262 3.85E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 Pfam PF00106 short chain dehydrogenase 9 210 1.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 158 186 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 92 103 2.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 171 190 2.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 159 2.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.9E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 190 1.9E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 161 1.9E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 1.9E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47150 955af6ef26f5e20b787c585721e3527c 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 192 209 1.9E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16975 51bdf3f68ece096dbc22cf7073df01c5 150 Pfam PF00741 Gas vesicle protein 19 56 1.2E-12 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS16975 51bdf3f68ece096dbc22cf7073df01c5 150 ProSitePatterns PS00669 Gas vesicles protein GVPa signature 2. 52 65 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS16975 51bdf3f68ece096dbc22cf7073df01c5 150 Hamap MF_00576 Gas vesicle structural protein [gvpA]. 7 95 28.481 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS16975 51bdf3f68ece096dbc22cf7073df01c5 150 ProSitePatterns PS00234 Gas vesicles protein GVPa signature 1. 19 33 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS48630 e31d26541c3bad629af99acd65a1338e 404 Gene3D G3DSA:3.40.50.261 246 369 4.0E-18 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS48630 e31d26541c3bad629af99acd65a1338e 404 SUPERFAMILY SSF52210 248 367 5.36E-16 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS48630 e31d26541c3bad629af99acd65a1338e 404 Gene3D G3DSA:3.30.1490.20 20 93 5.6E-10 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS48630 e31d26541c3bad629af99acd65a1338e 404 Pfam PF08442 ATP-grasp domain 14 187 4.6E-11 T 17-03-2017 IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS48630 e31d26541c3bad629af99acd65a1338e 404 SUPERFAMILY SSF56059 11 204 7.63E-26 T 17-03-2017 SHXM_RS48630 e31d26541c3bad629af99acd65a1338e 404 Gene3D G3DSA:3.30.470.20 94 206 7.8E-13 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS21205 e0c2354cb2750fe174037965d12c96c9 236 SUPERFAMILY SSF158682 92 230 1.83E-8 T 17-03-2017 IPR029024 TerB-like SHXM_RS21205 e0c2354cb2750fe174037965d12c96c9 236 Pfam PF05099 Tellurite resistance protein TerB 108 228 2.9E-8 T 17-03-2017 IPR007791 Co-chaperone DjlA, N-terminal SHXM_RS21205 e0c2354cb2750fe174037965d12c96c9 236 Gene3D G3DSA:1.10.3680.10 182 230 1.0E-4 T 17-03-2017 IPR029024 TerB-like SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 SUPERFAMILY SSF88946 19 88 5.1E-9 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 SUPERFAMILY SSF88659 109 179 2.43E-12 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 Gene3D G3DSA:1.10.1740.10 19 92 5.1E-9 T 17-03-2017 SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 Pfam PF04542 Sigma-70 region 2 39 92 1.4E-7 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 Pfam PF08281 Sigma-70, region 4 122 173 3.5E-10 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 Gene3D G3DSA:1.10.10.10 118 179 3.6E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16180 f884c5e99569914636f01b3831e71718 182 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 23 177 2.5E-19 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 SUPERFAMILY SSF64288 61 241 1.7E-29 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 Pfam PF00392 Bacterial regulatory proteins, gntR family 11 73 2.2E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 SMART SM00345 14 73 6.6E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 Pfam PF07702 UTRA domain 100 234 7.3E-19 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 Gene3D G3DSA:1.10.10.10 5 73 2.3E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 Gene3D G3DSA:3.40.1410.10 74 239 5.3E-43 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 SUPERFAMILY SSF46785 2 82 2.33E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09740 3b82a112e3be15e624d1f3d0ef6877ae 247 SMART SM00866 92 236 1.6E-13 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS20565 b43b7e08e6d406a556420de593c98e4e 148 Gene3D G3DSA:1.10.10.10 8 80 2.1E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20565 b43b7e08e6d406a556420de593c98e4e 148 SUPERFAMILY SSF46785 9 83 1.03E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20565 b43b7e08e6d406a556420de593c98e4e 148 SMART SM00345 20 79 9.8E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS20565 b43b7e08e6d406a556420de593c98e4e 148 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 79 3.9E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34005 14829e4a670a0b00f7faf46118c1421b 325 SMART SM00382 47 223 5.8E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS34005 14829e4a670a0b00f7faf46118c1421b 325 SUPERFAMILY SSF52540 21 235 5.93E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34005 14829e4a670a0b00f7faf46118c1421b 325 Pfam PF00005 ABC transporter 40 174 2.4E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS34005 14829e4a670a0b00f7faf46118c1421b 325 Gene3D G3DSA:3.40.50.300 19 238 4.0E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 SUPERFAMILY SSF53822 64 335 4.71E-72 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 Pfam PF13377 Periplasmic binding protein-like domain 171 335 5.3E-35 T 17-03-2017 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 SMART SM00354 4 74 1.1E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 Gene3D G3DSA:1.10.260.40 6 63 1.8E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 ProSitePatterns PS00356 LacI-type HTH domain signature. 7 25 - T 17-03-2017 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 Gene3D G3DSA:3.40.50.2300 64 171 2.2E-34 T 17-03-2017 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 SUPERFAMILY SSF47413 5 62 1.69E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 Gene3D G3DSA:3.40.50.2300 172 335 7.9E-55 T 17-03-2017 SHXM_RS11360 2c535a632245cd0c1b177a6f2e4a8e8a 341 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 50 9.7E-17 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Pfam PF02811 PHP domain 341 431 5.6E-6 T 17-03-2017 IPR004013 PHP domain GO:0003824 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 298 315 4.4E-9 T 17-03-2017 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 239 247 4.4E-9 T 17-03-2017 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 254 261 4.4E-9 T 17-03-2017 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 PRINTS PR00870 DNA-polymerase family X pol beta-like signature 59 76 4.4E-9 T 17-03-2017 IPR002008 DNA polymerase family X, beta-like GO:0003677|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 PIRSF PIRSF005047 3 575 4.0E-208 T 17-03-2017 IPR022311 Uncharacterised conserved protein UCP005047, YshC KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Gene3D G3DSA:3.30.210.10 256 316 6.3E-25 T 17-03-2017 IPR029398 DNA polymerase beta, thumb domain SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SUPERFAMILY SSF158702 54 148 2.48E-6 T 17-03-2017 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Pfam PF14716 Helix-hairpin-helix domain 5 72 1.1E-17 T 17-03-2017 IPR010996 DNA polymerase beta-like, N-terminal domain SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Pfam PF14520 Helix-hairpin-helix domain 92 144 4.0E-9 T 17-03-2017 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SUPERFAMILY SSF47802 4 82 1.7E-14 T 17-03-2017 IPR010996 DNA polymerase beta-like, N-terminal domain SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Gene3D G3DSA:3.20.20.140 338 574 4.9E-47 T 17-03-2017 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Pfam PF14791 DNA polymerase beta thumb 255 316 6.7E-22 T 17-03-2017 IPR029398 DNA polymerase beta, thumb domain SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SMART SM00483 3 316 7.0E-19 T 17-03-2017 IPR002054 DNA-directed DNA polymerase X GO:0003677|GO:0003887 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SMART SM00278 127 146 64.0 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SMART SM00278 52 71 17.0 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SMART SM00278 92 111 220.0 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SUPERFAMILY SSF81301 156 316 3.54E-43 T 17-03-2017 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Gene3D G3DSA:1.10.8.310 3 84 4.4E-17 T 17-03-2017 IPR027420 DNA polymerase beta, N-terminal domain SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Gene3D G3DSA:3.30.460.10 141 255 2.3E-17 T 17-03-2017 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 Pfam PF14792 DNA polymerase beta palm 156 230 2.0E-6 T 17-03-2017 IPR028207 DNA polymerase beta, palm domain SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SMART SM00481 340 420 1.9E-9 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS06870 4188073872faa2ac648b6103701e2dd8 581 SUPERFAMILY SSF89550 339 575 4.05E-49 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00065 753 905 9.8E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1127 1137 1.2E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1144 1162 1.2E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1109 1123 1.2E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1168 1181 1.2E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF55874 1002 1186 6.81E-44 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Pfam PF00072 Response regulator receiver domain 1280 1392 1.0E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00388 945 1013 4.4E-22 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF58104 188 328 2.01E-7 T 17-03-2017 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF58104 53 85 2.01E-7 T 17-03-2017 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF55781 722 896 3.92E-25 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Gene3D G3DSA:3.40.50.2300 1277 1397 5.3E-39 T 17-03-2017 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF52172 1274 1397 2.13E-37 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 31 83 5.6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 588 640 1.2E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 496 548 5.6E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 123 180 3.0E-5 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 220 272 4.9E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 312 364 1.4E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 680 732 2.6E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00304 404 456 4.6E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Pfam PF13185 GAF domain 752 895 5.1E-17 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1061 1182 5.4E-25 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00387 1060 1184 2.2E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF47384 936 1014 7.46E-19 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF158472 591 637 8.63E-5 T 17-03-2017 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Gene3D G3DSA:3.30.450.40 728 896 3.4E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Gene3D G3DSA:3.30.565.10 1000 1183 6.6E-43 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Pfam PF00512 His Kinase A (phospho-acceptor) domain 946 1013 2.6E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SUPERFAMILY SSF58104 332 605 1.83E-18 T 17-03-2017 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Pfam PF00672 HAMP domain 309 360 3.0E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Pfam PF00672 HAMP domain 585 636 8.5E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 SMART SM00448 1278 1392 2.1E-36 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17465 787c34efc6d0c22ee4dfe62fe9a0bab9 1529 Gene3D G3DSA:1.10.287.130 940 999 1.3E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 45 9.7E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 Pfam PF13377 Periplasmic binding protein-like domain 163 325 4.8E-36 T 17-03-2017 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 Gene3D G3DSA:3.40.50.2300 168 304 8.3E-42 T 17-03-2017 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 Gene3D G3DSA:1.10.260.40 1 50 1.9E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 SUPERFAMILY SSF53822 63 328 9.42E-53 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 SUPERFAMILY SSF47413 1 56 2.19E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 Gene3D G3DSA:3.40.50.2300 51 167 9.4E-30 T 17-03-2017 SHXM_RS02985 3f75f5c4f56ecf3aaf1fe11385238200 337 SMART SM00354 1 68 1.5E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 SUPERFAMILY SSF56574 274 389 5.11E-12 T 17-03-2017 IPR023796 Serpin domain SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 SUPERFAMILY SSF56574 19 167 1.96E-14 T 17-03-2017 IPR023796 Serpin domain SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 SMART SM00093 11 389 0.004 T 17-03-2017 IPR023796 Serpin domain SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 Gene3D G3DSA:2.30.39.10 337 389 2.1E-6 T 17-03-2017 SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 Gene3D G3DSA:3.30.497.10 23 159 1.0E-17 T 17-03-2017 SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 Gene3D G3DSA:3.30.497.10 280 336 1.0E-17 T 17-03-2017 SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 Pfam PF00079 Serpin (serine protease inhibitor) 21 165 6.1E-12 T 17-03-2017 IPR023796 Serpin domain SHXM_RS13295 11f584a999be056d602fdd7429190caf 397 Pfam PF00079 Serpin (serine protease inhibitor) 274 389 5.2E-8 T 17-03-2017 IPR023796 Serpin domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 PRINTS PR00344 Bacterial sensor protein C-terminal signature 496 514 2.4E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 PRINTS PR00344 Bacterial sensor protein C-terminal signature 463 477 2.4E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 PRINTS PR00344 Bacterial sensor protein C-terminal signature 520 533 2.4E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Gene3D G3DSA:1.10.287.130 316 375 1.2E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 425 535 9.6E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Gene3D G3DSA:3.30.565.10 392 539 3.5E-30 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Gene3D G3DSA:3.30.450.20 228 286 4.9E-7 T 17-03-2017 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Pfam PF00989 PAS fold 227 265 7.4E-6 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Pfam PF17203 Single cache domain 3 48 180 5.1E-25 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 SUPERFAMILY SSF55874 392 537 1.57E-30 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 SMART SM00091 226 291 0.0037 T 17-03-2017 IPR000014 PAS domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 SUPERFAMILY SSF55785 229 300 6.11E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 SMART SM00387 424 536 1.1E-25 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 SUPERFAMILY SSF103190 49 179 5.49E-31 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Gene3D G3DSA:3.30.450.20 45 180 1.4E-43 T 17-03-2017 SHXM_RS37495 72abdfa445d06770f822054bb15816de 552 Pfam PF14689 Sensor_kinase_SpoOB-type, alpha-helical domain 329 374 1.7E-7 T 17-03-2017 SHXM_RS14570 6f91b319b13f12d3f368b1c48a2cac7e 327 SMART SM00849 77 283 0.006 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14570 6f91b319b13f12d3f368b1c48a2cac7e 327 Pfam PF12706 Beta-lactamase superfamily domain 90 284 1.5E-46 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14570 6f91b319b13f12d3f368b1c48a2cac7e 327 Gene3D G3DSA:3.60.15.10 64 308 7.2E-80 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14570 6f91b319b13f12d3f368b1c48a2cac7e 327 SUPERFAMILY SSF56281 71 301 1.26E-37 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS17420 a6b3942aded990b2df66c4e1d99b31fe 593 Gene3D G3DSA:1.50.10.10 213 588 3.5E-86 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS17420 a6b3942aded990b2df66c4e1d99b31fe 593 SUPERFAMILY SSF48208 203 588 3.33E-104 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS17420 a6b3942aded990b2df66c4e1d99b31fe 593 Pfam PF00723 Glycosyl hydrolases family 15 217 538 1.4E-66 T 17-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 SUPERFAMILY SSF55060 173 292 1.49E-28 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 Pfam PF00288 GHMP kinases N terminal domain 88 151 2.4E-12 T 17-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain. 94 105 - T 17-03-2017 IPR006203 GHMP kinase, ATP-binding, conserved site GO:0005524 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 Hamap MF_00384 Homoserine kinase [thrB]. 11 300 29.844 T 17-03-2017 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 Gene3D G3DSA:3.30.230.10 10 160 2.6E-58 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 TIGRFAM TIGR00191 thrB: homoserine kinase 11 281 1.3E-64 T 17-03-2017 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 PRINTS PR00958 Homoserine kinase signature 254 269 3.1E-34 T 17-03-2017 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 PRINTS PR00958 Homoserine kinase signature 18 33 3.1E-34 T 17-03-2017 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 PRINTS PR00958 Homoserine kinase signature 177 194 3.1E-34 T 17-03-2017 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 PRINTS PR00958 Homoserine kinase signature 138 151 3.1E-34 T 17-03-2017 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 PRINTS PR00958 Homoserine kinase signature 101 116 3.1E-34 T 17-03-2017 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 Pfam PF08544 GHMP kinases C terminal 222 280 7.1E-6 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 PIRSF PIRSF000676 7 300 5.2E-85 T 17-03-2017 IPR000870 Homoserine kinase GO:0004413|GO:0005524|GO:0006566 KEGG: 00260+2.7.1.39|MetaCyc: PWY-702 SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 Gene3D G3DSA:3.30.70.890 171 291 7.7E-35 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS35175 a87293df27f3d6c29f8d1984349f0e2f 304 SUPERFAMILY SSF54211 11 156 1.21E-29 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 Gene3D G3DSA:1.10.10.10 126 216 1.8E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 SUPERFAMILY SSF52172 2 128 3.42E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 SMART SM00448 2 117 6.0E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 Pfam PF00072 Response regulator receiver domain 4 117 7.3E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 SMART SM00421 152 209 7.6E-24 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 5.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 5.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 5.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 SUPERFAMILY SSF46894 145 215 8.84E-22 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 Pfam PF00196 Bacterial regulatory proteins, luxR family 154 209 6.8E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43215 6ce3076a8603806294ef5754b77c6ca6 221 Gene3D G3DSA:3.40.50.2300 2 125 1.1E-38 T 17-03-2017 SHXM_RS36570 f52149c8040b20e10c4cfadf2cf5b655 147 ProSitePatterns PS00732 Ribosomal protein S16 signature. 3 12 - T 17-03-2017 IPR020592 Ribosomal protein S16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36570 f52149c8040b20e10c4cfadf2cf5b655 147 Gene3D G3DSA:3.30.1320.10 2 83 1.6E-32 T 17-03-2017 IPR023803 Ribosomal protein S16 domain Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36570 f52149c8040b20e10c4cfadf2cf5b655 147 TIGRFAM TIGR00002 S16: ribosomal protein bS16 3 79 2.1E-32 T 17-03-2017 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36570 f52149c8040b20e10c4cfadf2cf5b655 147 SUPERFAMILY SSF54565 2 98 2.49E-33 T 17-03-2017 IPR023803 Ribosomal protein S16 domain Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36570 f52149c8040b20e10c4cfadf2cf5b655 147 Pfam PF00886 Ribosomal protein S16 9 67 1.8E-23 T 17-03-2017 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36570 f52149c8040b20e10c4cfadf2cf5b655 147 Hamap MF_00385 30S ribosomal protein S16 [rpsP]. 2 77 23.804 T 17-03-2017 IPR000307 Ribosomal protein S16 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS39070 dd0aa39dd8e98920e81aba7ed570e2d5 296 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 73 295 1.8E-43 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS39070 dd0aa39dd8e98920e81aba7ed570e2d5 296 SMART SM00062 72 296 2.8E-45 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS39070 dd0aa39dd8e98920e81aba7ed570e2d5 296 Gene3D G3DSA:3.40.190.10 69 150 1.3E-28 T 17-03-2017 SHXM_RS39070 dd0aa39dd8e98920e81aba7ed570e2d5 296 Gene3D G3DSA:3.40.190.10 256 295 1.3E-28 T 17-03-2017 SHXM_RS39070 dd0aa39dd8e98920e81aba7ed570e2d5 296 SUPERFAMILY SSF53850 24 295 4.67E-53 T 17-03-2017 SHXM_RS39070 dd0aa39dd8e98920e81aba7ed570e2d5 296 Gene3D G3DSA:3.40.190.10 151 242 6.7E-11 T 17-03-2017 SHXM_RS27690 07258fde8471fa1bcb4a6ca02ee2fe71 284 Gene3D G3DSA:3.40.50.1000 18 89 8.0E-49 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27690 07258fde8471fa1bcb4a6ca02ee2fe71 284 Gene3D G3DSA:3.40.50.1000 184 279 8.0E-49 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27690 07258fde8471fa1bcb4a6ca02ee2fe71 284 SUPERFAMILY SSF56784 18 279 2.34E-56 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27690 07258fde8471fa1bcb4a6ca02ee2fe71 284 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 21 248 2.1E-24 T 17-03-2017 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: R-HSA-446205 SHXM_RS27690 07258fde8471fa1bcb4a6ca02ee2fe71 284 TIGRFAM TIGR00099 Cof-subfamily: Cof-like hydrolase 21 275 2.3E-44 T 17-03-2017 IPR000150 Cof protein GO:0016787 SHXM_RS27690 07258fde8471fa1bcb4a6ca02ee2fe71 284 Pfam PF08282 haloacid dehalogenase-like hydrolase 22 275 2.7E-43 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS39065 bd546cbdd6aa0e950fec9352d043f3d4 217 Pfam PF01081 KDPG and KHG aldolase 13 188 6.8E-44 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS39065 bd546cbdd6aa0e950fec9352d043f3d4 217 Gene3D G3DSA:3.20.20.70 6 204 4.0E-68 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS39065 bd546cbdd6aa0e950fec9352d043f3d4 217 SUPERFAMILY SSF51569 5 198 3.3E-58 T 17-03-2017 SHXM_RS39065 bd546cbdd6aa0e950fec9352d043f3d4 217 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 12 188 1.7E-52 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS39065 bd546cbdd6aa0e950fec9352d043f3d4 217 ProSitePatterns PS00160 KDPG and KHG aldolases Schiff-base forming residue. 127 140 - T 17-03-2017 IPR031338 KDPG/KHG aldolase, active site 2 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 392 401 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 Pfam PF00067 Cytochrome P450 12 429 1.6E-79 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 Gene3D G3DSA:1.10.630.10 9 454 3.0E-112 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 SUPERFAMILY SSF48264 7 452 2.62E-107 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00463 E-class P450 group I signature 354 378 1.5E-22 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00463 E-class P450 group I signature 399 422 1.5E-22 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00463 E-class P450 group I signature 38 57 1.5E-22 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00463 E-class P450 group I signature 252 269 1.5E-22 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00463 E-class P450 group I signature 272 298 1.5E-22 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00463 E-class P450 group I signature 389 399 1.5E-22 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00385 P450 superfamily signature 315 326 4.6E-13 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00385 P450 superfamily signature 399 410 4.6E-13 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00385 P450 superfamily signature 390 399 4.6E-13 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS13355 7325e6f51954e27291a0522f44fec6f4 477 PRINTS PR00385 P450 superfamily signature 263 280 4.6E-13 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33535 ac933c9e9601f88bf0df1166128f8ebf 179 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 112 160 4.4E-21 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS33535 ac933c9e9601f88bf0df1166128f8ebf 179 Pfam PF02627 Carboxymuconolactone decarboxylase family 94 175 5.6E-16 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS33535 ac933c9e9601f88bf0df1166128f8ebf 179 Hamap MF_01676 Alkyl hydroperoxide reductase AhpD [ahpD]. 1 179 86.986 T 17-03-2017 IPR004674 Alkylhydroperoxidase AhpD GO:0006979|GO:0032843|GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS33535 ac933c9e9601f88bf0df1166128f8ebf 179 TIGRFAM TIGR00777 ahpD: alkylhydroperoxidase, AhpD family 3 177 8.4E-92 T 17-03-2017 IPR004674 Alkylhydroperoxidase AhpD GO:0006979|GO:0032843|GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS33535 ac933c9e9601f88bf0df1166128f8ebf 179 Gene3D G3DSA:1.20.1290.10 1 175 2.1E-59 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS33535 ac933c9e9601f88bf0df1166128f8ebf 179 SUPERFAMILY SSF69118 3 171 1.44E-49 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS26540 94e1f92df4f6c279adfe8edb58de3e9f 383 SUPERFAMILY SSF54631 245 365 1.52E-9 T 17-03-2017 SHXM_RS26540 94e1f92df4f6c279adfe8edb58de3e9f 383 Gene3D G3DSA:3.10.580.10 271 365 9.4E-9 T 17-03-2017 SHXM_RS26540 94e1f92df4f6c279adfe8edb58de3e9f 383 Pfam PF02163 Peptidase family M50 139 184 4.7E-9 T 17-03-2017 IPR008915 Peptidase M50 GO:0004222|GO:0006508 Reactome: R-HSA-1655829|Reactome: R-HSA-381033 SHXM_RS26540 94e1f92df4f6c279adfe8edb58de3e9f 383 PIRSF PIRSF006404 1 374 4.0E-80 T 17-03-2017 IPR016483 Uncharacterised conserved protein UCP006404, peptidase M50/CBS SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 SUPERFAMILY SSF52279 365 434 6.41E-44 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 SUPERFAMILY SSF52279 567 723 6.41E-44 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 365 720 1.0E-46 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 SUPERFAMILY SSF51445 52 344 4.42E-95 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 SMART SM01217 753 824 3.1E-22 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 93 330 2.8E-56 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 PRINTS PR00133 Glycosyl hydrolase family 3 signature 117 136 3.1E-31 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 PRINTS PR00133 Glycosyl hydrolase family 3 signature 194 210 3.1E-31 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 PRINTS PR00133 Glycosyl hydrolase family 3 signature 263 281 3.1E-31 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 PRINTS PR00133 Glycosyl hydrolase family 3 signature 93 109 3.1E-31 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 PRINTS PR00133 Glycosyl hydrolase family 3 signature 163 179 3.1E-31 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 Gene3D G3DSA:3.20.20.300 53 339 1.9E-105 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 Pfam PF14310 Fibronectin type III-like domain 753 824 3.7E-19 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 Gene3D G3DSA:3.40.50.1700 567 723 2.0E-56 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS04255 5794941377d790a48e0494bc321d17e6 839 Gene3D G3DSA:3.40.50.1700 352 434 2.0E-56 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Gene3D G3DSA:3.90.55.10 458 558 1.6E-27 T 17-03-2017 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Pfam PF01568 Molydopterin dinucleotide binding domain 628 741 3.2E-20 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Gene3D G3DSA:3.40.228.10 171 364 2.3E-53 T 17-03-2017 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 SUPERFAMILY SSF50692 619 762 1.6E-35 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 SUPERFAMILY SSF53706 15 630 6.02E-147 T 17-03-2017 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 ProSitePatterns PS00490 Prokaryotic molybdopterin oxidoreductases signature 2. 456 473 - T 17-03-2017 IPR006655 Molybdopterin oxidoreductase, prokaryotic, conserved site GO:0009055|GO:0016491|GO:0055114 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Gene3D G3DSA:3.40.50.740 57 151 7.5E-39 T 17-03-2017 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Gene3D G3DSA:3.40.50.740 365 457 7.5E-39 T 17-03-2017 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Gene3D G3DSA:2.40.40.20 602 762 4.2E-43 T 17-03-2017 SHXM_RS06030 6b4cab31ebcaaead757c16631b0b040c 764 Pfam PF00384 Molybdopterin oxidoreductase 57 510 4.5E-61 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 SUPERFAMILY SSF51230 509 580 1.7E-19 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Pfam PF02785 Biotin carboxylase C-terminal domain 333 441 3.6E-36 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 SMART SM00878 333 441 2.0E-56 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Pfam PF00289 Biotin carboxylase, N-terminal domain 2 109 1.5E-43 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Gene3D G3DSA:3.40.50.20 2 128 3.9E-49 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 SUPERFAMILY SSF56059 114 321 1.2E-58 T 17-03-2017 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 285 292 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 537 554 - T 17-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Gene3D G3DSA:3.30.470.20 202 446 8.6E-90 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Gene3D G3DSA:3.30.1490.20 129 201 3.5E-21 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Pfam PF00364 Biotin-requiring enzyme 515 580 2.8E-17 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 SUPERFAMILY SSF51246 328 444 1.26E-36 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 114 319 3.8E-75 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 Gene3D G3DSA:2.40.50.100 510 581 4.6E-22 T 17-03-2017 SHXM_RS24700 fd657915c27fd2d1ddbb149c253a32ff 582 SUPERFAMILY SSF52440 2 112 8.63E-46 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS27555 9861ccf984632ef242a51ab9b1134cad 295 Gene3D G3DSA:3.20.20.80 63 289 5.4E-56 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS27555 9861ccf984632ef242a51ab9b1134cad 295 Pfam PF08924 Domain of unknown function (DUF1906) 75 211 1.2E-32 T 17-03-2017 IPR015020 Protein of unknown function DUF1906 SHXM_RS27555 9861ccf984632ef242a51ab9b1134cad 295 SUPERFAMILY SSF51445 63 288 4.21E-29 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS36360 3ca31b7d5bb292d9868291d0edf6a6a7 197 SUPERFAMILY SSF52016 1 188 1.24E-53 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS36360 3ca31b7d5bb292d9868291d0edf6a6a7 197 TIGRFAM TIGR00171 leuD: 3-isopropylmalate dehydratase, small subunit 1 180 1.2E-56 T 17-03-2017 IPR004431 3-isopropylmalate dehydratase, small subunit GO:0003861|GO:0009098|GO:0009316 KEGG: 00290+4.2.1.33 SHXM_RS36360 3ca31b7d5bb292d9868291d0edf6a6a7 197 Hamap MF_01031 3-isopropylmalate dehydratase small subunit [leuD]. 1 191 40.311 T 17-03-2017 IPR004431 3-isopropylmalate dehydratase, small subunit GO:0003861|GO:0009098|GO:0009316 KEGG: 00290+4.2.1.33 SHXM_RS36360 3ca31b7d5bb292d9868291d0edf6a6a7 197 Pfam PF00694 Aconitase C-terminal domain 1 117 5.7E-28 T 17-03-2017 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36360 3ca31b7d5bb292d9868291d0edf6a6a7 197 Gene3D G3DSA:3.20.19.10 1 187 1.1E-42 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS35120 03bfbd99b80f3de8918139b7b1cdc541 108 Pfam PF00392 Bacterial regulatory proteins, gntR family 8 68 2.1E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS35120 03bfbd99b80f3de8918139b7b1cdc541 108 SMART SM00345 11 68 2.8E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS35120 03bfbd99b80f3de8918139b7b1cdc541 108 SUPERFAMILY SSF46785 4 72 3.29E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35120 03bfbd99b80f3de8918139b7b1cdc541 108 Gene3D G3DSA:1.10.10.10 4 70 4.5E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35120 03bfbd99b80f3de8918139b7b1cdc541 108 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 58 3.8E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS35120 03bfbd99b80f3de8918139b7b1cdc541 108 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 28 42 3.8E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 SUPERFAMILY SSF53474 6 479 3.46E-104 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 PRINTS PR00878 Cholinesterase signature 112 141 5.0E-7 T 17-03-2017 IPR000997 Cholinesterase GO:0004104 Reactome: R-HSA-112311|Reactome: R-HSA-1483191|Reactome: R-HSA-422085 SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 PRINTS PR00878 Cholinesterase signature 418 430 5.0E-7 T 17-03-2017 IPR000997 Cholinesterase GO:0004104 Reactome: R-HSA-112311|Reactome: R-HSA-1483191|Reactome: R-HSA-422085 SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 181 196 - T 17-03-2017 IPR019826 Carboxylesterase type B, active site SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 ProSitePatterns PS00941 Carboxylesterases type-B signature 2. 85 95 - T 17-03-2017 IPR019819 Carboxylesterase type B, conserved site SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 Gene3D G3DSA:3.40.50.1820 6 476 2.9E-119 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46370 7454d7e1ea55f2f2947d869336cb4ad5 483 Pfam PF00135 Carboxylesterase family 6 476 2.3E-93 T 17-03-2017 IPR002018 Carboxylesterase, type B SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Gene3D G3DSA:1.10.10.350 487 582 1.7E-20 T 17-03-2017 IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Gene3D G3DSA:2.30.30.300 226 259 1.2E-9 T 17-03-2017 IPR023386 Lysine-tRNA ligase, insertion domain GO:0004824 KEGG: 00970+6.1.1.6 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Pfam PF01921 tRNA synthetases class I (K) 17 399 4.2E-126 T 17-03-2017 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 TIGRFAM TIGR00467 lysS_arch: lysine--tRNA ligase 220 581 6.7E-55 T 17-03-2017 IPR002904 Lysine-tRNA ligase GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Hamap MF_00177 Lysine--tRNA ligase [lysS]. 16 583 30.749 T 17-03-2017 IPR002904 Lysine-tRNA ligase GO:0000166|GO:0004824|GO:0005524|GO:0005737|GO:0006430 KEGG: 00970+6.1.1.6 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 47 56 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 SUPERFAMILY SSF52374 235 367 3.92E-49 T 17-03-2017 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 SUPERFAMILY SSF52374 30 203 3.92E-49 T 17-03-2017 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Gene3D G3DSA:3.40.50.620 268 318 2.4E-54 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Gene3D G3DSA:3.40.50.620 218 225 2.4E-54 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Gene3D G3DSA:3.40.50.620 26 175 2.4E-54 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 SUPERFAMILY SSF48163 373 581 9.68E-22 T 17-03-2017 IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding GO:0000049 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 SHXM_RS30530 d6c234a2f27893ba8130a766c9a9142f 583 Gene3D G3DSA:3.40.50.620 319 369 5.1E-4 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 90 354 3.5E-59 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 PRINTS PR00133 Glycosyl hydrolase family 3 signature 177 193 1.1E-20 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 PRINTS PR00133 Glycosyl hydrolase family 3 signature 131 150 1.1E-20 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 PRINTS PR00133 Glycosyl hydrolase family 3 signature 208 224 1.1E-20 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 PRINTS PR00133 Glycosyl hydrolase family 3 signature 108 124 1.1E-20 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 PRINTS PR00133 Glycosyl hydrolase family 3 signature 278 296 1.1E-20 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 398 645 7.4E-50 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 Gene3D G3DSA:3.20.20.300 6 368 1.5E-95 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 SUPERFAMILY SSF51445 5 44 4.32E-87 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 SUPERFAMILY SSF51445 72 370 4.32E-87 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 SUPERFAMILY SSF52279 398 647 1.83E-47 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 SMART SM01217 683 753 1.2E-16 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 Pfam PF14310 Fibronectin type III-like domain 683 753 1.5E-11 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS11200 b97fd75b7c2d0a4a363ead7a9a2185bf 764 Gene3D G3DSA:3.40.50.1700 387 647 3.5E-67 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 PIRSF PIRSF001438 1 310 5.6E-97 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 TIGRFAM TIGR00212 hemC: hydroxymethylbilane synthase 6 299 6.5E-96 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 Gene3D G3DSA:3.40.190.10 5 111 2.6E-34 T 17-03-2017 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 ProSitePatterns PS00533 Porphobilinogen deaminase cofactor-binding site. 232 248 - T 17-03-2017 IPR022419 Porphobilinogen deaminase, dipyrromethane cofactor binding site GO:0004418|GO:0018160|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 SUPERFAMILY SSF54782 222 308 2.22E-18 T 17-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 SUPERFAMILY SSF53850 6 218 1.99E-65 T 17-03-2017 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 Hamap MF_00260 Porphobilinogen deaminase [hemC]. 5 299 33.526 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 Gene3D G3DSA:3.30.160.40 225 307 3.0E-17 T 17-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 Gene3D G3DSA:3.40.190.10 112 200 2.0E-32 T 17-03-2017 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 Pfam PF03900 Porphobilinogen deaminase, C-terminal domain 226 297 9.7E-13 T 17-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 Pfam PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain 6 214 9.9E-62 T 17-03-2017 IPR022417 Porphobilinogen deaminase, N-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 PRINTS PR00151 Porphobilinogen deaminase signature 231 248 2.3E-26 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 PRINTS PR00151 Porphobilinogen deaminase signature 44 64 2.3E-26 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 PRINTS PR00151 Porphobilinogen deaminase signature 144 161 2.3E-26 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 PRINTS PR00151 Porphobilinogen deaminase signature 75 94 2.3E-26 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS14830 8a45b3593a38ab98778dbeda2625014b 310 PRINTS PR00151 Porphobilinogen deaminase signature 125 142 2.3E-26 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS38640 209f6c7525166bda294424bd3ecd9fda 198 Gene3D G3DSA:3.90.1570.10 16 187 8.7E-19 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS38640 209f6c7525166bda294424bd3ecd9fda 198 SUPERFAMILY SSF52980 16 172 1.98E-21 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS38640 209f6c7525166bda294424bd3ecd9fda 198 Pfam PF05685 Putative restriction endonuclease 21 187 1.7E-19 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 Pfam PF02875 Mur ligase family, glutamate ligase domain 360 439 1.1E-12 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 ProSitePatterns PS01012 Folylpolyglutamate synthase signature 2. 200 215 - T 17-03-2017 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 Gene3D G3DSA:3.40.1190.10 76 359 5.3E-95 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 SUPERFAMILY SSF53623 62 357 2.34E-88 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 SUPERFAMILY SSF53244 361 499 1.04E-27 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 Pfam PF08245 Mur ligase middle domain 104 331 1.6E-14 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 Gene3D G3DSA:3.90.190.20 361 500 2.4E-39 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS21665 fc49a49be6841486b43f98e407c0d1d9 501 TIGRFAM TIGR01499 folC: bifunctional protein FolC 83 495 3.7E-101 T 17-03-2017 IPR001645 Folylpolyglutamate synthetase GO:0004326|GO:0005524|GO:0009396 KEGG: 00790+6.3.2.17|MetaCyc: PWY-2161|Reactome: R-HSA-196757 SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 SMART SM00487 23 218 7.2E-22 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Pfam PF00270 DEAD/DEAH box helicase 29 196 1.5E-16 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Gene3D G3DSA:1.10.10.10 444 500 6.5E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 TIGRFAM TIGR00614 recQ_fam: ATP-dependent DNA helicase, RecQ family 23 362 1.3E-68 T 17-03-2017 IPR004589 DNA helicase, ATP-dependent, RecQ type GO:0006310|GO:0008026 SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Gene3D G3DSA:3.40.50.300 220 368 4.5E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Pfam PF16124 RecQ zinc-binding 446 488 1.5E-5 T 17-03-2017 IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 SUPERFAMILY SSF52540 35 355 3.58E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Gene3D G3DSA:3.40.50.2020 653 718 5.5E-9 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Gene3D G3DSA:3.40.50.300 14 206 3.2E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 Pfam PF00271 Helicase conserved C-terminal domain 248 345 5.2E-13 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 SMART SM00490 265 346 1.4E-21 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS37440 310bbdc7acb1dd1dd53efdcaf3e7dfaa 721 SUPERFAMILY SSF53271 655 717 7.08E-10 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 Gene3D G3DSA:1.10.275.10 5 142 2.2E-56 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 Pfam PF10415 Fumarase C C-terminus 411 462 3.6E-19 T 17-03-2017 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 Gene3D G3DSA:1.10.40.30 411 464 1.5E-19 T 17-03-2017 SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 SUPERFAMILY SSF48557 6 461 6.33E-151 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 Pfam PF00206 Lyase 15 345 9.7E-109 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 PRINTS PR00149 Fumarate lyase superfamily signature 183 201 4.7E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 PRINTS PR00149 Fumarate lyase superfamily signature 320 336 4.7E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 PRINTS PR00149 Fumarate lyase superfamily signature 138 156 4.7E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 PRINTS PR00149 Fumarate lyase superfamily signature 274 301 4.7E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 Gene3D G3DSA:1.20.200.10 143 406 1.6E-90 T 17-03-2017 SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 ProSitePatterns PS00163 Fumarate lyases signature. 320 329 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS06090 7994b9db2ae92c37eabb9cecbf56f267 466 TIGRFAM TIGR00839 aspA: aspartate ammonia-lyase 7 462 3.0E-208 T 17-03-2017 IPR004708 Aspartate ammonia-lyase GO:0006531|GO:0008797 KEGG: 00250+4.3.1.1 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 SMART SM00448 2 115 1.7E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 SMART SM00421 138 195 2.3E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 Gene3D G3DSA:3.40.50.2300 2 143 3.6E-32 T 17-03-2017 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 Pfam PF00072 Response regulator receiver domain 5 115 3.0E-20 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 Pfam PF00196 Bacterial regulatory proteins, luxR family 140 195 6.2E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 SUPERFAMILY SSF46894 128 201 2.31E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 SUPERFAMILY SSF52172 2 128 1.57E-28 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 Gene3D G3DSA:1.10.10.10 144 201 1.2E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 141 155 6.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 183 6.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 171 6.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19750 af5e47ce1ed324c3097d23713efe4eee 201 ProSitePatterns PS00622 LuxR-type HTH domain signature. 155 182 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 Gene3D G3DSA:3.30.420.10 124 317 2.1E-42 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 SUPERFAMILY SSF53098 181 323 8.98E-35 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 SUPERFAMILY SSF53098 132 143 8.98E-35 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 Pfam PF00665 Integrase core domain 129 279 5.1E-38 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 Pfam PF13011 leucine-zipper of insertion element IS481 1 72 2.9E-11 T 17-03-2017 IPR024967 DNA-binding domain, IS481-type SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 SUPERFAMILY SSF46689 7 80 8.42E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00800 deef38e1c21be31461cf81b089c6ce77 328 Gene3D G3DSA:1.10.10.60 11 64 7.9E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46880 3c71a80a14e756197dc5cc8f70f4aac8 322 SUPERFAMILY SSF53474 3 318 9.27E-28 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46880 3c71a80a14e756197dc5cc8f70f4aac8 322 Gene3D G3DSA:3.40.50.1820 1 319 1.2E-91 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46880 3c71a80a14e756197dc5cc8f70f4aac8 322 Pfam PF05448 Acetyl xylan esterase (AXE1) 1 318 2.7E-121 T 17-03-2017 IPR008391 Acetyl xylan esterase SHXM_RS48290 f43e2756f62b421b9c9d877e650c0b3f 274 SUPERFAMILY SSF53681 107 217 7.36E-24 T 17-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48290 f43e2756f62b421b9c9d877e650c0b3f 274 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1. 67 75 - T 17-03-2017 IPR018187 Asp/Glu racemase, active site 1 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48290 f43e2756f62b421b9c9d877e650c0b3f 274 SUPERFAMILY SSF53681 1 104 1.31E-21 T 17-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48290 f43e2756f62b421b9c9d877e650c0b3f 274 ProSitePatterns PS00924 Aspartate and glutamate racemases signature 2. 173 183 - T 17-03-2017 IPR033134 Asp/Glu racemase, active site 2 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48290 f43e2756f62b421b9c9d877e650c0b3f 274 Pfam PF01177 Asp/Glu/Hydantoin racemase 28 208 1.8E-19 T 17-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48290 f43e2756f62b421b9c9d877e650c0b3f 274 Gene3D G3DSA:3.40.50.1860 2 156 6.7E-31 T 17-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 SUPERFAMILY SSF54826 1 125 1.28E-21 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 SMART SM00922 140 236 1.4E-13 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 Gene3D G3DSA:3.30.390.10 1 125 1.2E-31 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 Gene3D G3DSA:3.20.20.120 126 341 4.2E-51 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 Pfam PF13378 Enolase C-terminal domain-like 148 343 2.4E-39 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 SUPERFAMILY SSF51604 110 343 1.14E-54 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS48415 a9e86a7175a91d0b68f467e520e73cbd 347 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 36 122 5.4E-9 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 SUPERFAMILY SSF51735 5 245 9.02E-88 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5 190 1.9E-6 T 17-03-2017 SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 2.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 2.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 2.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 244 2.9E-69 T 17-03-2017 SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 2.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 2.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 2.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 2.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 208 228 2.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 2.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 Gene3D G3DSA:3.40.50.720 4 245 7.6E-89 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02165 23560ccace0660d4472e27af0c0701f2 246 TIGRFAM TIGR01830 3oxo_ACP_reduc: 3-oxoacyl-[acyl-carrier-protein] reductase 7 245 3.9E-93 T 17-03-2017 IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase GO:0004316|GO:0006633|GO:0051287|GO:0055114 KEGG: 00040+1.1.1.10|KEGG: 00061+1.1.1.100|KEGG: 00780+1.1.1.100|MetaCyc: PWY-5367|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS30165 6b076904ab41f75797a681707b37fe2c 221 Pfam PF00005 ABC transporter 18 166 1.1E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30165 6b076904ab41f75797a681707b37fe2c 221 SMART SM00382 27 214 4.5E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30165 6b076904ab41f75797a681707b37fe2c 221 SUPERFAMILY SSF52540 1 217 6.92E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30165 6b076904ab41f75797a681707b37fe2c 221 Gene3D G3DSA:3.40.50.300 2 217 9.5E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30165 6b076904ab41f75797a681707b37fe2c 221 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 Gene3D G3DSA:3.30.450.20 11 92 2.1E-10 T 17-03-2017 SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 SMART SM00421 124 181 1.7E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 11 107 2.3E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 Pfam PF00989 PAS fold 26 108 5.2E-6 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 Pfam PF00196 Bacterial regulatory proteins, luxR family 126 180 1.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 Gene3D G3DSA:1.10.10.10 93 188 2.8E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 SUPERFAMILY SSF46894 119 187 8.5E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS06995 3823577778ff8de9688cb760d145db3e 202 SUPERFAMILY SSF55785 9 104 1.96E-10 T 17-03-2017 IPR000014 PAS domain SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Pfam PF00364 Biotin-requiring enzyme 586 649 4.3E-17 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 118 313 2.1E-63 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Pfam PF02785 Biotin carboxylase C-terminal domain 325 429 3.2E-28 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 SUPERFAMILY SSF51230 573 650 8.9E-20 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 SUPERFAMILY SSF51246 319 433 2.25E-32 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 SMART SM00878 325 428 5.2E-42 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Gene3D G3DSA:3.30.470.20 195 434 6.3E-90 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Gene3D G3DSA:3.40.50.20 2 129 1.1E-45 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Pfam PF00289 Biotin carboxylase, N-terminal domain 2 110 2.2E-40 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Gene3D G3DSA:2.40.50.100 581 650 4.7E-23 T 17-03-2017 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 607 624 - T 17-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 Gene3D G3DSA:3.30.1490.20 143 193 1.5E-17 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 SUPERFAMILY SSF56059 83 323 1.47E-59 T 17-03-2017 SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 SUPERFAMILY SSF52440 2 113 8.63E-43 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS25605 41ad9d460cf1a1f45f2d198faf83cfcf 654 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 277 284 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS26910 793f7785b729b6deb8cb055b5d2268c3 65 Pfam PF14029 Protein of unknown function (DUF4244) 11 62 3.9E-25 T 17-03-2017 IPR025338 Protein of unknown function DUF4244 SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 Gene3D G3DSA:3.30.70.920 59 151 2.7E-20 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 Pfam PF13404 AsnC-type helix-turn-helix domain 7 48 9.9E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 ProSitePatterns PS00519 AsnC-type HTH domain signature. 25 51 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 SMART SM00344 7 113 2.5E-23 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 SUPERFAMILY SSF54909 68 152 3.08E-18 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 Pfam PF01037 Lrp/AsnC ligand binding domain 77 143 2.2E-14 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 Gene3D G3DSA:1.10.10.10 5 53 3.3E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 23 34 1.1E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 34 53 1.1E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 7 23 1.1E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00355 4afe6a79035e8abe8e2fc531e95aa7bd 166 SUPERFAMILY SSF46785 7 81 3.23E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 SUPERFAMILY SSF52518 411 620 2.94E-46 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 PIRSF PIRSF000156 11 780 1.7E-63 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 SUPERFAMILY SSF52518 13 391 1.57E-60 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 SUPERFAMILY SSF52922 636 779 1.57E-22 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 62 236 1.3E-8 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 Gene3D G3DSA:3.40.50.970 417 628 3.3E-66 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 Gene3D G3DSA:3.40.50.920 641 779 6.3E-33 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 SMART SM00861 416 620 4.5E-7 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS48860 c951bc15a94062c0d26623ff9e117e07 780 Gene3D G3DSA:3.40.50.970 15 391 2.6E-91 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 Gene3D G3DSA:1.10.10.10 11 79 2.7E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 Gene3D G3DSA:3.30.420.40 80 224 4.9E-36 T 17-03-2017 SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 SUPERFAMILY SSF46785 12 75 1.05E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 ProSitePatterns PS01125 ROK family signature. 221 248 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 SUPERFAMILY SSF53067 83 410 5.37E-51 T 17-03-2017 SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 Gene3D G3DSA:3.30.420.40 225 393 1.7E-42 T 17-03-2017 SHXM_RS11490 dbe4eda13266c3b1c297af6b38d593bd 417 Pfam PF00480 ROK family 86 405 3.4E-48 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS34910 9176c5a75edaf4c93285e27e28a5b839 1057 SMART SM00387 547 663 1.2E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34910 9176c5a75edaf4c93285e27e28a5b839 1057 Pfam PF08376 Nitrate and nitrite sensing 80 305 5.2E-37 T 17-03-2017 IPR013587 Nitrate/nitrite sensing protein SHXM_RS34910 9176c5a75edaf4c93285e27e28a5b839 1057 Pfam PF00672 HAMP domain 327 394 4.0E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS34910 9176c5a75edaf4c93285e27e28a5b839 1057 Gene3D G3DSA:3.30.565.10 514 662 3.7E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34910 9176c5a75edaf4c93285e27e28a5b839 1057 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 551 660 2.4E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34910 9176c5a75edaf4c93285e27e28a5b839 1057 SUPERFAMILY SSF55874 536 663 2.36E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39455 f1d9265f997acd73e7c2237d6aee39ba 109 SUPERFAMILY SSF57716 76 106 6.11E-8 T 17-03-2017 SHXM_RS39455 f1d9265f997acd73e7c2237d6aee39ba 109 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 75 106 8.9E-11 T 17-03-2017 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 Gene3D G3DSA:3.40.50.720 136 296 2.5E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 SMART SM00829 18 327 7.2E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 Pfam PF00107 Zinc-binding dehydrogenase 153 283 1.1E-17 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 Pfam PF16884 N-terminal domain of oxidoreductase 10 105 2.7E-24 T 17-03-2017 SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 SUPERFAMILY SSF50129 8 137 4.27E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 SUPERFAMILY SSF51735 118 295 8.0E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40405 59aebee722924b53478aa1c7e87492af 334 Gene3D G3DSA:3.90.180.10 7 135 8.4E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 Gene3D G3DSA:1.10.10.10 23 88 1.6E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 Pfam PF00392 Bacterial regulatory proteins, gntR family 28 86 5.5E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 Gene3D G3DSA:1.20.120.530 94 230 1.9E-30 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 Pfam PF07729 FCD domain 100 226 3.9E-28 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 SUPERFAMILY SSF48008 96 231 1.54E-27 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 SUPERFAMILY SSF46785 24 92 5.07E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 SMART SM00345 31 89 6.2E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS41715 290b463c5a27885f578c609934d30e8f 236 SMART SM00895 100 226 2.8E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Pfam PF00204 DNA gyrase B 260 452 1.1E-55 T 17-03-2017 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Gene3D G3DSA:3.30.230.10 259 452 6.7E-50 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 ProSitePatterns PS00177 DNA topoisomerase II signature. 484 492 - T 17-03-2017 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 SUPERFAMILY SSF56719 456 698 1.05E-74 T 17-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Gene3D G3DSA:3.40.50.670 466 686 5.4E-74 T 17-03-2017 IPR013759 DNA topoisomerase, type IIA, central domain GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 52 67 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 326 339 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 586 598 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 482 496 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 87 100 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 566 583 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 130 144 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 548 564 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR00418 DNA topoisomerase II family signature 637 653 5.8E-59 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 48 163 5.3E-21 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 SMART SM00387 48 208 1.7E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Pfam PF01751 Toprim domain 481 582 2.4E-14 T 17-03-2017 IPR006171 Toprim domain SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Pfam PF00986 DNA gyrase B subunit, carboxyl terminus 636 693 1.5E-24 T 17-03-2017 IPR002288 DNA gyrase B subunit, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 Gene3D G3DSA:3.30.565.10 23 244 7.9E-80 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 SMART SM00433 52 698 9.9E-279 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 SUPERFAMILY SSF55874 23 242 3.14E-58 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 229 242 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 259 281 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 214 229 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 370 386 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 674 690 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 23 33 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 532 541 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 436 456 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 PRINTS PR01159 DNA gyrase subunit B signature 658 670 3.4E-36 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS37480 570911bd33a672318f6a8539e1cb93ed 707 SUPERFAMILY SSF54211 260 452 9.48E-40 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS24865 e5cfab04a85b3ac98e5834554dfb3db0 344 Pfam PF02608 Basic membrane protein 42 340 2.3E-51 T 17-03-2017 IPR003760 ABC transporter substrate-binding protein PnrA-like GO:0005886 SHXM_RS24865 e5cfab04a85b3ac98e5834554dfb3db0 344 SUPERFAMILY SSF53822 47 257 1.56E-10 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS24865 e5cfab04a85b3ac98e5834554dfb3db0 344 Gene3D G3DSA:3.40.50.2300 157 311 7.2E-44 T 17-03-2017 SHXM_RS24865 e5cfab04a85b3ac98e5834554dfb3db0 344 Gene3D G3DSA:3.40.50.2300 32 156 1.8E-41 T 17-03-2017 SHXM_RS13425 71b20c6b548adba07161350dc8904826 357 Gene3D G3DSA:3.40.50.1970 9 157 8.6E-28 T 17-03-2017 SHXM_RS13425 71b20c6b548adba07161350dc8904826 357 Pfam PF13685 Iron-containing alcohol dehydrogenase 16 270 3.7E-54 T 17-03-2017 IPR032837 Glycerol-1-phosphate dehydrogenase KEGG: 00564+1.1.1.261|KEGG: 00630+1.1.1.26|MetaCyc: PWY-6349|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS13425 71b20c6b548adba07161350dc8904826 357 PIRSF PIRSF000112 2 354 3.2E-100 T 17-03-2017 SHXM_RS13425 71b20c6b548adba07161350dc8904826 357 Gene3D G3DSA:1.20.1090.10 159 349 5.5E-60 T 17-03-2017 SHXM_RS13425 71b20c6b548adba07161350dc8904826 357 SUPERFAMILY SSF56796 10 347 4.19E-57 T 17-03-2017 SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 SUPERFAMILY SSF48239 244 552 1.08E-45 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 Gene3D G3DSA:1.50.10.20 254 553 5.9E-54 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 Gene3D G3DSA:1.50.10.20 12 253 3.5E-17 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 244 261 0.33 T 17-03-2017 IPR001330 PFTB repeat GO:0003824 SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 Pfam PF13249 Squalene-hopene cyclase N-terminal domain 16 127 3.1E-7 T 17-03-2017 IPR032697 Squalene cyclase, N-terminal Reactome: R-HSA-191273|Reactome: R-HSA-2426168 SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 SUPERFAMILY SSF48239 41 304 2.75E-22 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS03745 9eb59392c427650eafa79e689e9cae4f 587 Pfam PF13243 Squalene-hopene cyclase C-terminal domain 379 520 4.7E-15 T 17-03-2017 IPR032696 Squalene cyclase, C-terminal Reactome: R-HSA-191273|Reactome: R-HSA-2426168 SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 ProSitePatterns PS00211 ABC transporters family signature. 158 172 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 Pfam PF00005 ABC transporter 29 185 8.1E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 237 306 1.4E-15 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 Gene3D G3DSA:3.40.50.300 7 259 6.4E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 SMART SM00382 37 235 4.2E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 237 326 1.1E-21 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS32970 bd3d3efa849e53af472547bd9ce0b043 356 SUPERFAMILY SSF52540 9 256 3.51E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37670 59f5828101961170248d07a92ea33779 222 Pfam PF02254 TrkA-N domain 3 116 4.8E-25 T 17-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 PRINTS PR00335 TrkA potassium uptake protein signature 2 16 2.3E-8 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 PRINTS PR00335 TrkA potassium uptake protein signature 19 33 2.3E-8 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 PRINTS PR00335 TrkA potassium uptake protein signature 73 87 2.3E-8 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 PRINTS PR00335 TrkA potassium uptake protein signature 60 70 2.3E-8 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 Gene3D G3DSA:3.30.70.1450 145 213 1.4E-6 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 Pfam PF02080 TrkA-C domain 150 213 3.1E-10 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 SUPERFAMILY SSF116726 138 211 4.32E-9 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS37670 59f5828101961170248d07a92ea33779 222 Gene3D G3DSA:3.40.50.720 1 139 2.5E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37670 59f5828101961170248d07a92ea33779 222 SUPERFAMILY SSF51735 1 140 1.34E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24250 3e6955e2ec431b17329eeb3ca16d658e 250 Gene3D G3DSA:3.40.50.980 7 89 2.2E-4 T 17-03-2017 SHXM_RS24250 3e6955e2ec431b17329eeb3ca16d658e 250 SUPERFAMILY SSF56801 3 247 3.92E-22 T 17-03-2017 SHXM_RS24250 3e6955e2ec431b17329eeb3ca16d658e 250 TIGRFAM TIGR03089 TIGR03089: TIGR03089 family protein 11 246 2.4E-82 T 17-03-2017 IPR017523 Conserved hypothetical protein CHP03089 SHXM_RS24250 3e6955e2ec431b17329eeb3ca16d658e 250 Gene3D G3DSA:3.40.50.980 169 248 5.3E-6 T 17-03-2017 SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 SUPERFAMILY SSF56801 6 576 6.8E-109 T 17-03-2017 SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 ProSitePatterns PS00455 Putative AMP-binding domain signature. 176 187 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 Gene3D G3DSA:3.40.50.980 183 349 5.6E-34 T 17-03-2017 SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 Gene3D G3DSA:2.30.38.10 382 461 1.3E-18 T 17-03-2017 SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 Pfam PF00501 AMP-binding enzyme 20 471 3.7E-78 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 Gene3D G3DSA:3.40.50.980 13 182 8.4E-31 T 17-03-2017 SHXM_RS39690 592e99c6a7f7c32c990026a11afe19d4 588 Gene3D G3DSA:3.30.300.30 463 571 7.8E-16 T 17-03-2017 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 Gene3D G3DSA:3.30.460.10 31 181 1.0E-42 T 17-03-2017 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 Pfam PF12627 Probable RNA and SrmB- binding site of polymerase A 209 270 2.8E-21 T 17-03-2017 IPR032828 tRNA nucleotidyltransferase/poly(A) polymerase, RNA and SrmB- binding domain Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 TIGRFAM TIGR00277 HDIG: HDIG domain 281 358 5.4E-17 T 17-03-2017 IPR006675 HDIG domain SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 Gene3D G3DSA:1.10.3090.10 436 458 2.1E-60 T 17-03-2017 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 Gene3D G3DSA:1.10.3090.10 182 368 2.1E-60 T 17-03-2017 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 SMART SM00471 280 435 3.1E-4 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 SUPERFAMILY SSF81891 180 492 1.57E-71 T 17-03-2017 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 TIGRFAM TIGR02692 tRNA_CCA_actino: CCA tRNA nucleotidyltransferase 23 491 2.8E-244 T 17-03-2017 IPR014065 tRNA adenylyltransferase SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 SUPERFAMILY SSF81301 32 179 5.01E-34 T 17-03-2017 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 Pfam PF01743 Poly A polymerase head domain 51 182 8.5E-30 T 17-03-2017 IPR002646 Poly A polymerase, head domain GO:0003723|GO:0006396|GO:0016779 Reactome: R-HSA-6784531|Reactome: R-HSA-6785470 SHXM_RS28035 abc556277f28dedc02bfc008563ff655 496 Pfam PF01966 HD domain 284 378 3.3E-14 T 17-03-2017 IPR006674 HD domain SHXM_RS50095 15dbb37c4bb271bb8e4556a7ce47fc39 382 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 168 184 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS50095 15dbb37c4bb271bb8e4556a7ce47fc39 382 SUPERFAMILY SSF53901 8 259 3.77E-58 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50095 15dbb37c4bb271bb8e4556a7ce47fc39 382 Gene3D G3DSA:3.40.47.10 7 267 1.2E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50095 15dbb37c4bb271bb8e4556a7ce47fc39 382 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 8 255 2.8E-59 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS50095 15dbb37c4bb271bb8e4556a7ce47fc39 382 SMART SM00825 Beta-ketoacyl synthase 7 370 4.8E-23 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SUPERFAMILY SSF49785 32 232 5.81E-54 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 343 575 6.9E-71 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:2.60.40.320 222 339 1.1E-28 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 617 767 4.7E-20 T 17-03-2017 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SMART SM00560 632 766 1.8E-17 T 17-03-2017 IPR006558 LamG-like jellyroll fold SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Pfam PF02929 Beta galactosidase small chain 959 1230 3.6E-60 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Pfam PF16353 Domain of unknown function(DUF4981) 842 928 4.1E-22 T 17-03-2017 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SUPERFAMILY SSF49303 234 341 1.93E-22 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SUPERFAMILY SSF74650 944 1233 1.26E-63 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:2.60.40.320 838 930 5.3E-28 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Pfam PF00703 Glycosyl hydrolases family 2 235 341 2.9E-15 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:3.20.20.80 340 568 8.8E-87 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:3.20.20.80 793 829 8.8E-87 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SMART SM01038 956 1231 6.0E-75 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 PRINTS PR00132 Glycosyl hydrolase family 2 signature 159 174 1.7E-30 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 PRINTS PR00132 Glycosyl hydrolase family 2 signature 457 472 1.7E-30 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 PRINTS PR00132 Glycosyl hydrolase family 2 signature 383 401 1.7E-30 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 PRINTS PR00132 Glycosyl hydrolase family 2 signature 352 366 1.7E-30 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 PRINTS PR00132 Glycosyl hydrolase family 2 signature 530 545 1.7E-30 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 62 232 1.1E-45 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:2.70.98.10 945 1233 1.4E-79 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:2.60.120.200 569 766 3.5E-26 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 Gene3D G3DSA:2.60.120.260 30 221 1.2E-64 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SUPERFAMILY SSF49899 581 769 3.24E-28 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SUPERFAMILY SSF49303 823 931 2.4E-25 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS13505 2d7a24625df18b12e827cb078e3de1eb 1246 SUPERFAMILY SSF51445 343 579 1.94E-70 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 SMART SM00382 93 247 2.2E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 Gene3D G3DSA:3.40.50.300 77 278 1.4E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 Pfam PF13481 AAA domain 85 225 5.5E-14 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 Hamap MF_01498 DNA repair protein RadA [radA]. 30 457 42.107 T 17-03-2017 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 Gene3D G3DSA:3.30.230.10 287 456 1.7E-31 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 Pfam PF13541 Subunit ChlI of Mg-chelatase 373 432 3.6E-8 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 SUPERFAMILY SSF52540 75 296 7.58E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 85 113 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 325 348 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 19 43 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 251 277 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 177 201 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 127 144 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 PRINTS PR01874 DNA repair protein radA signature 216 244 1.2E-85 T 17-03-2017 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 TIGRFAM TIGR00416 sms: DNA repair protein RadA 11 453 3.4E-153 T 17-03-2017 IPR004504 DNA repair protein RadA GO:0003684|GO:0005524|GO:0006281 SHXM_RS30310 94430ed885b198dcf109e959a624fdb7 474 SUPERFAMILY SSF54211 296 456 5.69E-34 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 Gene3D G3DSA:3.40.50.1220 178 326 6.2E-26 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 SUPERFAMILY SSF52467 148 344 4.28E-26 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 186 318 2.3E-17 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 1 163 1.1E-40 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 Gene3D G3DSA:3.40.50.970 1 173 5.2E-40 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 Gene3D G3DSA:3.40.50.970 352 534 1.2E-38 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 387 517 8.4E-23 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 SUPERFAMILY SSF52518 358 536 2.68E-38 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS41270 f750f256e8741b42ee5198e2143411ba 546 SUPERFAMILY SSF52518 1 173 2.06E-37 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS03540 ff9abb8ecbe746c1585011d02203160f 376 Pfam PF00296 Luciferase-like monooxygenase 9 339 7.0E-77 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS03540 ff9abb8ecbe746c1585011d02203160f 376 Gene3D G3DSA:3.20.20.30 1 254 1.7E-93 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS03540 ff9abb8ecbe746c1585011d02203160f 376 Gene3D G3DSA:3.20.20.30 301 370 1.7E-93 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS03540 ff9abb8ecbe746c1585011d02203160f 376 SUPERFAMILY SSF51679 19 368 5.1E-81 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Gene3D G3DSA:2.60.200.20 14 88 5.4E-23 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Gene3D G3DSA:2.60.200.20 263 340 4.0E-22 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 SUPERFAMILY SSF49879 221 361 1.17E-24 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Gene3D G3DSA:3.40.50.300 352 586 7.3E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Pfam PF00498 FHA domain 270 328 8.5E-15 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Pfam PF00498 FHA domain 21 84 1.9E-15 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 SMART SM00382 380 574 1.3E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Pfam PF00005 ABC transporter 371 518 4.2E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 SUPERFAMILY SSF49879 9 92 3.25E-22 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 Pfam PF01061 ABC-2 type transporter 648 860 4.7E-19 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 ProSitePatterns PS00211 ABC transporters family signature. 490 504 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 SUPERFAMILY SSF52540 350 587 1.46E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 SMART SM00240 268 319 3.5E-14 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS41665 5261992cca3c5d2fd9de7772d9c8d8f7 925 SMART SM00240 20 70 4.7E-8 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS48885 04197ef0e7da42953561d66283bef2d3 121 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 12 116 4.1E-10 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS48885 04197ef0e7da42953561d66283bef2d3 121 Gene3D G3DSA:3.10.180.10 18 118 8.8E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS48885 04197ef0e7da42953561d66283bef2d3 121 SUPERFAMILY SSF54593 11 120 1.06E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS42835 7be97f3a42387c6675babab3d224f90f 370 Gene3D G3DSA:3.40.630.30 190 298 2.8E-6 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS42835 7be97f3a42387c6675babab3d224f90f 370 TIGRFAM TIGR01681 HAD-SF-IIIC: HAD phosphatase, family IIIC 15 123 1.2E-19 T 17-03-2017 IPR010033 HAD-superfamily phosphatase, subfamily IIIC SHXM_RS42835 7be97f3a42387c6675babab3d224f90f 370 Gene3D G3DSA:3.40.50.1000 13 120 1.7E-20 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42835 7be97f3a42387c6675babab3d224f90f 370 TIGRFAM TIGR01686 FkbH: FkbH domain 12 321 7.2E-111 T 17-03-2017 IPR010037 FkbH domain SHXM_RS42835 7be97f3a42387c6675babab3d224f90f 370 SUPERFAMILY SSF56784 14 116 8.55E-16 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42835 7be97f3a42387c6675babab3d224f90f 370 SUPERFAMILY SSF55729 190 298 1.26E-5 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS46905 a089e8586016aa928ec61464a710a2f9 302 Gene3D G3DSA:3.90.180.10 1 142 2.0E-25 T 17-03-2017 IPR011032 GroES-like SHXM_RS46905 a089e8586016aa928ec61464a710a2f9 302 Gene3D G3DSA:3.40.50.720 143 267 4.3E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46905 a089e8586016aa928ec61464a710a2f9 302 SUPERFAMILY SSF51735 106 270 1.48E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46905 a089e8586016aa928ec61464a710a2f9 302 SMART SM00829 12 299 1.6E-10 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS46905 a089e8586016aa928ec61464a710a2f9 302 SUPERFAMILY SSF50129 1 137 6.24E-21 T 17-03-2017 IPR011032 GroES-like SHXM_RS46905 a089e8586016aa928ec61464a710a2f9 302 Pfam PF00107 Zinc-binding dehydrogenase 143 234 4.5E-18 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS31240 dbe3a2d9159c55f9891e0fae70da29c6 132 Hamap MF_01302_B 30S ribosomal protein S8 [rpsH]. 2 132 31.049 T 17-03-2017 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31240 dbe3a2d9159c55f9891e0fae70da29c6 132 SUPERFAMILY SSF56047 3 132 2.09E-44 T 17-03-2017 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31240 dbe3a2d9159c55f9891e0fae70da29c6 132 Gene3D G3DSA:3.30.1490.10 76 132 7.5E-29 T 17-03-2017 SHXM_RS31240 dbe3a2d9159c55f9891e0fae70da29c6 132 Gene3D G3DSA:3.30.1370.30 2 72 4.0E-28 T 17-03-2017 SHXM_RS31240 dbe3a2d9159c55f9891e0fae70da29c6 132 Pfam PF00410 Ribosomal protein S8 5 132 1.6E-50 T 17-03-2017 IPR000630 Ribosomal protein S8 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 SUPERFAMILY SSF49303 586 686 4.82E-28 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 SMART SM01038 710 989 3.0E-54 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 SUPERFAMILY SSF49785 20 203 1.98E-62 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 SUPERFAMILY SSF74650 716 988 1.73E-58 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Pfam PF16353 Domain of unknown function(DUF4981) 601 686 4.0E-21 T 17-03-2017 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 34 203 4.1E-44 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 294 593 1.7E-98 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 ProSitePatterns PS00719 Glycosyl hydrolases family 2 signature 1. 344 369 - T 17-03-2017 IPR023230 Glycoside hydrolase, family 2, conserved site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Gene3D G3DSA:2.60.40.320 193 292 8.9E-14 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 PRINTS PR00132 Glycosyl hydrolase family 2 signature 409 424 4.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 PRINTS PR00132 Glycosyl hydrolase family 2 signature 334 352 4.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 PRINTS PR00132 Glycosyl hydrolase family 2 signature 131 146 4.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 PRINTS PR00132 Glycosyl hydrolase family 2 signature 303 317 4.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 PRINTS PR00132 Glycosyl hydrolase family 2 signature 496 511 4.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 409 423 - T 17-03-2017 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Pfam PF02929 Beta galactosidase small chain 730 983 1.4E-42 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 SUPERFAMILY SSF51445 294 588 1.51E-91 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Gene3D G3DSA:2.60.120.260 29 192 2.8E-67 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Gene3D G3DSA:2.60.40.320 590 692 2.9E-27 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Gene3D G3DSA:3.20.20.80 293 588 6.7E-96 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 Gene3D G3DSA:2.70.98.10 730 988 2.6E-54 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS48720 69ec0de4c7a2cc9484a7df0f7e00eb5a 991 SUPERFAMILY SSF49303 206 293 2.01E-15 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 SUPERFAMILY SSF53955 41 118 4.66E-31 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 Gene3D G3DSA:3.10.350.10 187 233 1.0E-12 T 17-03-2017 IPR018392 LysM domain SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 SMART SM00257 186 234 1.0E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 SUPERFAMILY SSF54106 186 233 7.32E-7 T 17-03-2017 IPR018392 LysM domain SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 Gene3D G3DSA:1.10.530.10 21 120 7.1E-42 T 17-03-2017 SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 Pfam PF01476 LysM domain 187 232 1.7E-9 T 17-03-2017 IPR018392 LysM domain SHXM_RS24555 e6a3f09d0ef524084f0374cc15dad846 234 Pfam PF06737 Transglycosylase-like domain 40 116 6.7E-35 T 17-03-2017 IPR010618 Transglycosylase-like SHXM_RS49740 e3aa1c78f03da51e4270ea4460aa2211 264 Gene3D G3DSA:3.40.50.300 19 259 3.7E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49740 e3aa1c78f03da51e4270ea4460aa2211 264 Pfam PF12399 Branched-chain amino acid ATP-binding cassette transporter 240 261 2.1E-5 T 17-03-2017 IPR032823 Branched-chain amino acid ATP-binding cassette transporter, C-terminal SHXM_RS49740 e3aa1c78f03da51e4270ea4460aa2211 264 ProSitePatterns PS00211 ABC transporters family signature. 162 176 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS49740 e3aa1c78f03da51e4270ea4460aa2211 264 Pfam PF00005 ABC transporter 38 190 8.1E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49740 e3aa1c78f03da51e4270ea4460aa2211 264 SMART SM00382 46 241 2.2E-4 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49740 e3aa1c78f03da51e4270ea4460aa2211 264 SUPERFAMILY SSF52540 20 261 2.56E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 Gene3D G3DSA:3.40.50.720 2 257 3.0E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.6E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 1.6E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 219 239 1.6E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 1.6E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 1.6E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 1.6E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 SUPERFAMILY SSF51735 7 257 7.66E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 256 7.7E-58 T 17-03-2017 SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 7.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 7.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06600 24c0324575a37addde6965ed2fcee177 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 7.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45890 15f89e9f899aefd6e3acf3553f7fbf6a 123 Gene3D G3DSA:1.10.10.10 12 76 1.8E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45890 15f89e9f899aefd6e3acf3553f7fbf6a 123 SUPERFAMILY SSF46785 12 119 2.67E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45890 15f89e9f899aefd6e3acf3553f7fbf6a 123 Pfam PF03965 Penicillinase repressor 12 119 2.2E-24 T 17-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SHXM_RS49305 128df94c80b25a67a437646ac4e0f7c3 124 SUPERFAMILY SSF54427 1 118 4.09E-13 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS49305 128df94c80b25a67a437646ac4e0f7c3 124 Pfam PF12680 SnoaL-like domain 10 110 1.7E-7 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS49305 128df94c80b25a67a437646ac4e0f7c3 124 Gene3D G3DSA:3.10.450.50 2 116 6.6E-10 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 Hamap MF_00179 GTP cyclohydrolase-2 [ribA]. 215 410 39.848 T 17-03-2017 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 Hamap MF_00180 3,4-dihydroxy-2-butanone 4-phosphate synthase [ribB]. 10 214 38.704 T 17-03-2017 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 SUPERFAMILY SSF142695 216 386 6.15E-64 T 17-03-2017 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 TIGRFAM TIGR00505 ribA: GTP cyclohydrolase II 219 407 3.5E-72 T 17-03-2017 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 Pfam PF00925 GTP cyclohydrolase II 218 383 2.1E-67 T 17-03-2017 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 Gene3D G3DSA:3.90.870.10 10 222 2.1E-96 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 TIGRFAM TIGR00506 ribB: 3,4-dihydroxy-2-butanone-4-phosphate synthase 12 210 4.1E-73 T 17-03-2017 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 Pfam PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase 16 209 3.9E-84 T 17-03-2017 IPR000422 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB GO:0008686|GO:0009231 KEGG: 00740+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 PIRSF PIRSF001259 11 415 1.0E-171 T 17-03-2017 SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 SUPERFAMILY SSF55821 10 211 5.26E-82 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS12155 d728c84101deb26d2bfc6f4b36261782 425 Hamap MF_01283 Riboflavin biosynthesis protein RibBA [ribBA]. 11 406 52.854 T 17-03-2017 IPR016299 Riboflavin biosynthesis protein RibBA GO:0009231 KEGG: 00740+3.5.4.25+4.1.99.12|MetaCyc: PWY-6167|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS34100 387614214c07c5381abaf50b56710002 272 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 81 238 5.3E-33 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34100 387614214c07c5381abaf50b56710002 272 SUPERFAMILY SSF88659 179 239 2.8E-17 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34100 387614214c07c5381abaf50b56710002 272 Pfam PF04542 Sigma-70 region 2 85 150 6.6E-21 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34100 387614214c07c5381abaf50b56710002 272 Gene3D G3DSA:1.10.10.10 177 240 4.8E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34100 387614214c07c5381abaf50b56710002 272 Gene3D G3DSA:1.10.1740.10 79 151 3.7E-26 T 17-03-2017 SHXM_RS34100 387614214c07c5381abaf50b56710002 272 SUPERFAMILY SSF88946 81 161 1.1E-23 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34100 387614214c07c5381abaf50b56710002 272 Pfam PF08281 Sigma-70, region 4 183 234 8.2E-17 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 172 268 5.3E-25 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 474 566 1.1E-27 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 SUPERFAMILY SSF51735 6 171 5.88E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 SUPERFAMILY SSF48179 474 569 4.34E-25 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Gene3D G3DSA:3.40.50.720 287 475 2.6E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Gene3D G3DSA:3.40.50.720 6 173 2.4E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 SUPERFAMILY SSF48179 171 273 4.08E-26 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 294 471 3.9E-53 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7 169 4.5E-28 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Gene3D G3DSA:1.10.1040.10 174 269 4.9E-27 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 Gene3D G3DSA:1.10.1040.10 476 567 1.2E-26 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS07260 a9bc519c34ca7a274380781be306e327 572 SUPERFAMILY SSF51735 290 471 1.14E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39635 b3cd4c79e849151b5d1f3a355d3ab233 424 SUPERFAMILY SSF51569 24 408 3.52E-150 T 17-03-2017 SHXM_RS39635 b3cd4c79e849151b5d1f3a355d3ab233 424 Pfam PF01474 Class-II DAHP synthetase family 188 405 1.8E-87 T 17-03-2017 IPR002480 DAHP synthetase, class II GO:0003849|GO:0009073 KEGG: 00400+2.5.1.54|MetaCyc: PWY-6164 SHXM_RS39635 b3cd4c79e849151b5d1f3a355d3ab233 424 Pfam PF01474 Class-II DAHP synthetase family 32 186 7.6E-49 T 17-03-2017 IPR002480 DAHP synthetase, class II GO:0003849|GO:0009073 KEGG: 00400+2.5.1.54|MetaCyc: PWY-6164 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 PRINTS PR00110 Alpha-amylase signature 201 212 3.0E-22 T 17-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 PRINTS PR00110 Alpha-amylase signature 288 300 3.0E-22 T 17-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 PRINTS PR00110 Alpha-amylase signature 230 248 3.0E-22 T 17-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 PRINTS PR00110 Alpha-amylase signature 112 123 3.0E-22 T 17-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 PRINTS PR00110 Alpha-amylase signature 80 97 3.0E-22 T 17-03-2017 IPR006046 Alpha amylase GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+3.2.1.1|Reactome: R-HSA-189085 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 386 455 1.1E-10 T 17-03-2017 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 Gene3D G3DSA:2.60.40.1180 380 456 9.8E-31 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 SMART SM00632 383 459 1.3E-40 T 17-03-2017 IPR031319 Alpha-amylase, C-terminal domain Reactome: R-HSA-189085 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 SUPERFAMILY SSF51445 35 376 3.91E-82 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 SUPERFAMILY SSF51011 379 459 1.23E-28 T 17-03-2017 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 SMART SM00642 37 374 2.7E-77 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 Gene3D G3DSA:3.20.20.80 33 378 2.8E-102 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS19250 4ee19ed919df95c9411a7456cc1e8080 462 Pfam PF00128 Alpha amylase, catalytic domain 89 338 1.5E-17 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS46315 9bf0f3a4a4e6e35cc22c23346fd8e578 389 Gene3D G3DSA:1.20.1090.10 193 389 1.9E-53 T 17-03-2017 SHXM_RS46315 9bf0f3a4a4e6e35cc22c23346fd8e578 389 Pfam PF00465 Iron-containing alcohol dehydrogenase 19 380 7.1E-108 T 17-03-2017 IPR001670 Alcohol dehydrogenase, iron-type GO:0016491|GO:0046872|GO:0055114 Reactome: R-HSA-880009 SHXM_RS46315 9bf0f3a4a4e6e35cc22c23346fd8e578 389 ProSitePatterns PS00913 Iron-containing alcohol dehydrogenases signature 1. 181 209 - T 17-03-2017 IPR018211 Alcohol dehydrogenase, iron-type, conserved site GO:0016491|GO:0046872|GO:0055114 SHXM_RS46315 9bf0f3a4a4e6e35cc22c23346fd8e578 389 ProSitePatterns PS00060 Iron-containing alcohol dehydrogenases signature 2. 268 288 - T 17-03-2017 IPR018211 Alcohol dehydrogenase, iron-type, conserved site GO:0016491|GO:0046872|GO:0055114 SHXM_RS46315 9bf0f3a4a4e6e35cc22c23346fd8e578 389 SUPERFAMILY SSF56796 18 387 6.93E-108 T 17-03-2017 SHXM_RS46315 9bf0f3a4a4e6e35cc22c23346fd8e578 389 Gene3D G3DSA:3.40.50.1970 19 192 1.4E-53 T 17-03-2017 SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 SMART SM00344 1 105 5.1E-28 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 Gene3D G3DSA:1.10.10.10 1 48 1.1E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 Pfam PF13404 AsnC-type helix-turn-helix domain 1 41 6.1E-18 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 SUPERFAMILY SSF46785 1 49 5.54E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 Pfam PF01037 Lrp/AsnC ligand binding domain 71 129 3.7E-8 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 SUPERFAMILY SSF54909 72 133 4.16E-10 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 Gene3D G3DSA:3.30.70.920 74 131 3.3E-12 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 5.5E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 5.5E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS49640 16f921b19616f952bb88d02853b4c46d 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 5.5E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF55048 803 867 4.58E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.40.47.10 400 567 6.6E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 300 316 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 515 637 4.1E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.40.366.10 867 981 4.1E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.40.366.10 665 798 4.1E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF14765 Polyketide synthase dehydratase 1044 1319 5.4E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF08659 KR domain 1865 2043 9.9E-63 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF53901 134 511 1.19E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00823 Phosphopantetheine attachment site 2147 2219 3.5E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00823 Phosphopantetheine attachment site 46 118 4.3E-21 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 395 512 1.0E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00829 1550 1855 1.0E-176 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF51735 1648 1789 1.92E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF47336 41 152 4.06E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF51735 1859 2059 4.4E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF50129 1560 1682 1.03E-25 T 17-03-2017 IPR011032 GroES-like SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.40.47.10 139 399 9.9E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM01294 2148 2215 9.0E-5 T 17-03-2017 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM01294 47 114 1.3E-4 T 17-03-2017 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF47336 2141 2225 1.96E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF00550 Phosphopantetheine attachment site 49 114 7.8E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF00550 Phosphopantetheine attachment site 2150 2215 6.6E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 137 387 4.1E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1865 2045 2.1E-66 T 17-03-2017 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.30.70.250 803 866 2.2E-8 T 17-03-2017 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF52151 669 804 3.92E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF52151 868 964 3.92E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.90.180.10 1565 1682 1.8E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF00107 Zinc-binding dehydrogenase 1688 1779 3.0E-16 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00825 Beta-ketoacyl synthase 139 565 4.4E-215 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 673 976 2.2E-122 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.40.50.720 1683 1778 2.5E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:3.40.50.720 1866 2066 1.4E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1569 1625 3.7E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SUPERFAMILY SSF51735 1330 1526 1.05E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Pfam PF00698 Acyl transferase domain 672 989 1.5E-60 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:1.10.1200.10 2145 2220 9.2E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 Gene3D G3DSA:1.10.1200.10 43 118 2.0E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45385 4cfc573ab9b8bc07af62f5f36e2448ea 2297 SMART SM00826 1044 1208 4.4E-76 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 SUPERFAMILY SSF56235 2 237 1.03E-66 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Gene3D G3DSA:3.40.50.10490 446 615 8.5E-63 T 17-03-2017 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Gene3D G3DSA:3.60.20.10 2 242 1.6E-75 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Gene3D G3DSA:3.40.50.10490 246 445 1.3E-66 T 17-03-2017 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Pfam PF13522 Glutamine amidotransferase domain 65 195 7.9E-23 T 17-03-2017 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 SUPERFAMILY SSF53697 247 615 6.31E-111 T 17-03-2017 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Pfam PF01380 SIS domain 464 596 1.0E-25 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Pfam PF01380 SIS domain 292 418 1.3E-34 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 Hamap MF_00164 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [glmS]. 1 615 41.209 T 17-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 SHXM_RS31395 57235b08203e2a3bdb9145f0cafb49f7 615 TIGRFAM TIGR01135 glmS: glutamine-fructose-6-phosphate transaminase (isomerizing) 2 615 1.0E-248 T 17-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 SHXM_RS19990 bc02230897721be871a61c5a81421a77 193 Pfam PF01169 Uncharacterized protein family UPF0016 10 79 4.5E-15 T 17-03-2017 IPR001727 Gdt1 family GO:0032472 SHXM_RS19990 bc02230897721be871a61c5a81421a77 193 Pfam PF01169 Uncharacterized protein family UPF0016 110 183 1.1E-18 T 17-03-2017 IPR001727 Gdt1 family GO:0032472 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 60 71 1.6E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 50 60 1.6E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.6E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 Gene3D G3DSA:3.40.190.10 191 283 3.0E-11 T 17-03-2017 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 Gene3D G3DSA:1.10.10.10 17 100 1.8E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 27 82 2.3E-16 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 SUPERFAMILY SSF46785 21 100 4.9E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 SUPERFAMILY SSF53850 106 312 2.53E-34 T 17-03-2017 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 Pfam PF03466 LysR substrate binding domain 110 312 4.6E-21 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 Gene3D G3DSA:3.40.190.10 112 190 1.0E-22 T 17-03-2017 SHXM_RS46815 743264c937eba6a3cdffbaa8155cc590 318 Gene3D G3DSA:3.40.190.10 288 314 1.0E-22 T 17-03-2017 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Pfam PF07691 PA14 domain 84 181 3.0E-27 T 17-03-2017 IPR011658 PA14 domain SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 356 452 1.3E-13 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 620 732 2.5E-7 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Gene3D G3DSA:2.60.40.320 477 577 8.9E-19 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 SUPERFAMILY SSF56988 43 252 6.41E-48 T 17-03-2017 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Gene3D G3DSA:2.60.120.260 313 476 8.7E-55 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Pfam PF00703 Glycosyl hydrolases family 2 533 579 1.1E-8 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 SMART SM00758 42 184 3.7E-42 T 17-03-2017 IPR011658 PA14 domain SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Gene3D G3DSA:3.90.182.10 31 191 1.7E-45 T 17-03-2017 IPR011658 PA14 domain SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 SUPERFAMILY SSF49303 489 580 6.04E-12 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 Gene3D G3DSA:3.20.20.80 578 852 2.8E-53 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 SUPERFAMILY SSF49785 313 485 3.16E-46 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS07855 3938e98db2d45fe2d4d115aa12ff3531 867 SUPERFAMILY SSF51445 576 851 6.84E-65 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 Hamap MF_00144 tRNA-specific 2-thiouridylase MnmA [mnmA]. 17 373 35.995 T 17-03-2017 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 Reactome: R-HSA-6787450 SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 Gene3D G3DSA:2.40.30.10 299 378 1.0E-17 T 17-03-2017 SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 SUPERFAMILY SSF52402 18 261 5.73E-46 T 17-03-2017 SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 Pfam PF03054 tRNA methyl transferase 18 372 2.8E-116 T 17-03-2017 SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 TIGRFAM TIGR00420 trmU: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase 19 372 2.1E-86 T 17-03-2017 IPR004506 tRNA-specific 2-thiouridylase GO:0008033|GO:0016740 Reactome: R-HSA-6787450 SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 Gene3D G3DSA:3.40.50.620 16 227 3.4E-76 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS36045 65ddb9e58c128298e1a8afe599d88d74 383 Gene3D G3DSA:2.30.30.280 231 291 3.6E-16 T 17-03-2017 IPR023382 Adenine nucleotide alpha hydrolase-like domains GO:0016783 Reactome: R-HSA-6787450 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 Pfam PF00196 Bacterial regulatory proteins, luxR family 140 195 1.5E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 Pfam PF00072 Response regulator receiver domain 4 115 1.1E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 SMART SM00448 2 115 3.2E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 Gene3D G3DSA:1.10.10.10 145 201 7.4E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 Gene3D G3DSA:3.40.50.2300 1 144 1.1E-33 T 17-03-2017 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 SUPERFAMILY SSF46894 125 201 5.44E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 SMART SM00421 138 195 4.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 183 8.8E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 171 8.8E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 141 155 8.8E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42520 e0426fdb94a9f401b6484356fa8247e9 201 SUPERFAMILY SSF52172 1 128 2.7E-29 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 Gene3D G3DSA:1.10.10.10 127 180 3.6E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 81 94 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 Pfam PF04545 Sigma-70, region 4 223 270 1.2E-15 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 Pfam PF04542 Sigma-70 region 2 57 126 2.8E-18 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 SUPERFAMILY SSF88659 130 203 6.54E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 Gene3D G3DSA:1.10.10.10 214 271 3.4E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 54 271 1.2E-32 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 51 272 3.8E-88 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 PRINTS PR00046 Major sigma-70 factor signature 81 94 5.5E-8 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 PRINTS PR00046 Major sigma-70 factor signature 226 238 5.5E-8 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 PRINTS PR00046 Major sigma-70 factor signature 243 258 5.5E-8 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 SUPERFAMILY SSF88659 208 272 1.07E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 SUPERFAMILY SSF88946 35 127 1.3E-30 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 Pfam PF04539 Sigma-70 region 3 136 199 3.3E-14 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27360 778729a3f0fc182f685d58552a43afed 277 Gene3D G3DSA:1.10.601.10 49 126 1.4E-25 T 17-03-2017 SHXM_RS41295 ddaf03f613ed3f58f8d9c943663cb3f7 191 SUPERFAMILY SSF46689 1 67 4.21E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41295 ddaf03f613ed3f58f8d9c943663cb3f7 191 Gene3D G3DSA:1.10.357.10 1 183 4.2E-17 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41295 ddaf03f613ed3f58f8d9c943663cb3f7 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 56 1.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 TIGRFAM TIGR01029 rpsG_bact: ribosomal protein uS7 3 156 5.9E-64 T 17-03-2017 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 SUPERFAMILY SSF47973 1 149 5.1E-56 T 17-03-2017 IPR023798 Ribosomal protein S7 domain SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 PIRSF PIRSF002122 7 156 5.9E-54 T 17-03-2017 IPR000235 Ribosomal protein S5/S7 GO:0006412 SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 Pfam PF00177 Ribosomal protein S7p/S5e 1 149 6.3E-59 T 17-03-2017 IPR023798 Ribosomal protein S7 domain SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 Gene3D G3DSA:1.10.455.10 8 156 1.4E-59 T 17-03-2017 IPR023798 Ribosomal protein S7 domain SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 Hamap MF_00480_B 30S ribosomal protein S7 [rpsG]. 1 156 34.635 T 17-03-2017 IPR005717 Ribosomal protein S7, bacterial/organellar-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS31130 9e7fe534c35ce2b844086c9d07201c55 156 ProSitePatterns PS00052 Ribosomal protein S7 signature. 20 46 - T 17-03-2017 IPR020606 Ribosomal protein S7, conserved site GO:0003723|GO:0003735|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 130 1.0E-32 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 57 71 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 SMART SM00829 7 327 1.0E-4 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 SUPERFAMILY SSF50129 1 138 3.35E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 SUPERFAMILY SSF50129 300 327 3.35E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 Pfam PF00107 Zinc-binding dehydrogenase 171 280 4.9E-11 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 Gene3D G3DSA:3.40.50.720 174 276 7.9E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 Gene3D G3DSA:3.90.180.10 1 173 1.8E-57 T 17-03-2017 IPR011032 GroES-like SHXM_RS07780 d31f83fdd9f4011bed6ae95257bff61d 329 SUPERFAMILY SSF51735 134 295 6.95E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 1.5E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 2.9E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 2.9E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 2.9E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 Pfam PF03466 LysR substrate binding domain 92 295 1.0E-46 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 Gene3D G3DSA:3.40.190.10 96 179 2.2E-18 T 17-03-2017 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 Gene3D G3DSA:3.40.190.10 180 262 3.3E-15 T 17-03-2017 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 SUPERFAMILY SSF46785 2 84 1.74E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 SUPERFAMILY SSF53850 94 297 2.17E-45 T 17-03-2017 SHXM_RS28810 b0c55019c8d9bcb02d71a78a53ad38e4 299 Gene3D G3DSA:1.10.10.10 2 84 1.7E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SUPERFAMILY SSF55785 167 281 4.71E-15 T 17-03-2017 IPR000014 PAS domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Gene3D G3DSA:3.30.450.20 48 157 1.3E-15 T 17-03-2017 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SMART SM00331 508 753 3.4E-44 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SUPERFAMILY SSF55785 49 157 1.02E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SUPERFAMILY SSF55781 296 494 3.6E-15 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SMART SM00065 353 487 1.5E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 171 289 4.5E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 48 163 1.6E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 534 754 2.2E-51 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SUPERFAMILY SSF81606 521 754 4.18E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SUPERFAMILY SSF55874 792 880 4.86E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Pfam PF08448 PAS fold 53 160 3.8E-11 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Pfam PF08448 PAS fold 174 285 2.5E-21 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Pfam PF01590 GAF domain 397 477 7.1E-7 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Gene3D G3DSA:3.30.450.20 162 283 1.7E-17 T 17-03-2017 SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 Gene3D G3DSA:3.30.450.40 300 485 3.6E-38 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SMART SM00091 167 233 5.5E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS33810 70072dbb879f568239ae56426a709e72 897 SMART SM00091 44 111 1.3E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 Gene3D G3DSA:3.40.1410.10 75 256 1.1E-45 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 SUPERFAMILY SSF46785 8 84 1.22E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 SMART SM00345 15 74 3.6E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 Gene3D G3DSA:1.10.10.10 10 74 3.3E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 Pfam PF00392 Bacterial regulatory proteins, gntR family 12 74 4.2E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 Pfam PF07702 UTRA domain 113 252 2.5E-12 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 SUPERFAMILY SSF64288 62 259 3.14E-22 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS06075 e49a2dec6ba7971d510829cf40d046ff 262 SMART SM00866 106 253 5.7E-9 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS37550 152ea3a6606f72a75ceccc33db04a0fd 413 SUPERFAMILY SSF53649 61 409 1.05E-58 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS37550 152ea3a6606f72a75ceccc33db04a0fd 413 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 65 398 2.6E-40 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS37550 152ea3a6606f72a75ceccc33db04a0fd 413 Gene3D G3DSA:3.40.720.10 57 337 2.8E-47 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS45040 3934fe85605a2a931bba34ddd763c87a 379 SUPERFAMILY SSF47203 237 370 6.93E-36 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS45040 3934fe85605a2a931bba34ddd763c87a 379 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 232 368 7.0E-28 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS45040 3934fe85605a2a931bba34ddd763c87a 379 SUPERFAMILY SSF56645 4 214 4.45E-24 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS45040 3934fe85605a2a931bba34ddd763c87a 379 Gene3D G3DSA:1.20.140.10 239 369 8.1E-35 T 17-03-2017 SHXM_RS45040 3934fe85605a2a931bba34ddd763c87a 379 Gene3D G3DSA:1.10.540.10 8 123 4.0E-14 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS45040 3934fe85605a2a931bba34ddd763c87a 379 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 10 101 3.8E-12 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS06800 dca53a96ed17d379d61223638dfe06b9 495 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS06800 dca53a96ed17d379d61223638dfe06b9 495 Pfam PF00171 Aldehyde dehydrogenase family 15 478 2.9E-175 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS06800 dca53a96ed17d379d61223638dfe06b9 495 Gene3D G3DSA:3.40.309.10 267 443 1.1E-70 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS06800 dca53a96ed17d379d61223638dfe06b9 495 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 280 291 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS06800 dca53a96ed17d379d61223638dfe06b9 495 Gene3D G3DSA:3.40.605.10 6 266 2.8E-95 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS06800 dca53a96ed17d379d61223638dfe06b9 495 SUPERFAMILY SSF53720 4 482 1.83E-169 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 Pfam PF08386 TAP-like protein 403 497 6.5E-20 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 SUPERFAMILY SSF53474 89 142 8.89E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 SUPERFAMILY SSF53474 183 237 8.89E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 SUPERFAMILY SSF53474 346 468 8.89E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 Gene3D G3DSA:3.40.50.1820 320 321 9.7E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 Gene3D G3DSA:3.40.50.1820 367 480 9.7E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 Gene3D G3DSA:3.40.50.1820 181 285 9.7E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 Gene3D G3DSA:3.40.50.1820 56 141 9.7E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13020 c569160359a77560d282c3fd56aeeade 526 Pfam PF00561 alpha/beta hydrolase fold 91 276 1.2E-24 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS30985 83d92d5d1d21e319beeede80200dd3cc 162 SUPERFAMILY SSF89963 5 88 3.14E-29 T 17-03-2017 IPR007551 Protein of unknown function DUF520 SHXM_RS30985 83d92d5d1d21e319beeede80200dd3cc 162 SUPERFAMILY SSF89963 90 162 3.4E-24 T 17-03-2017 IPR007551 Protein of unknown function DUF520 SHXM_RS30985 83d92d5d1d21e319beeede80200dd3cc 162 Gene3D G3DSA:3.30.70.990 11 96 2.7E-32 T 17-03-2017 SHXM_RS30985 83d92d5d1d21e319beeede80200dd3cc 162 Pfam PF04461 Protein of unknown function (DUF520) 4 162 5.0E-62 T 17-03-2017 IPR007551 Protein of unknown function DUF520 SHXM_RS30985 83d92d5d1d21e319beeede80200dd3cc 162 Gene3D G3DSA:3.30.70.860 97 162 4.8E-30 T 17-03-2017 SHXM_RS30985 83d92d5d1d21e319beeede80200dd3cc 162 Hamap MF_00632 UPF0234 protein YajQ [yajQ]. 3 162 26.177 T 17-03-2017 IPR007551 Protein of unknown function DUF520 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 SUPERFAMILY SSF53822 54 329 1.41E-67 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 Pfam PF13377 Periplasmic binding protein-like domain 167 326 1.3E-39 T 17-03-2017 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 SUPERFAMILY SSF47413 3 52 1.77E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 47 4.5E-17 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 Gene3D G3DSA:3.40.50.2300 53 167 1.6E-22 T 17-03-2017 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 SMART SM00354 2 64 1.9E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 Gene3D G3DSA:3.40.50.2300 168 328 2.3E-52 T 17-03-2017 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 ProSitePatterns PS00356 LacI-type HTH domain signature. 5 23 - T 17-03-2017 SHXM_RS47225 983617676243c5bf044fa32230f0e4e8 331 Gene3D G3DSA:1.10.260.40 3 47 3.7E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS17550 eaf0e41afc491c2c69ba2cc26108d4c5 363 Gene3D G3DSA:3.90.1150.10 256 359 5.5E-17 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS17550 eaf0e41afc491c2c69ba2cc26108d4c5 363 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 213 226 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS17550 eaf0e41afc491c2c69ba2cc26108d4c5 363 Gene3D G3DSA:3.40.640.10 47 255 1.8E-50 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS17550 eaf0e41afc491c2c69ba2cc26108d4c5 363 SUPERFAMILY SSF53383 30 357 9.22E-60 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS17550 eaf0e41afc491c2c69ba2cc26108d4c5 363 Pfam PF00155 Aminotransferase class I and II 35 351 5.3E-32 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 SUPERFAMILY SSF51905 247 582 1.46E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 SMART SM00100 44 162 4.1E-17 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 SUPERFAMILY SSF51206 47 168 6.94E-24 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 362 370 1.0E-34 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 492 513 1.0E-34 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 261 283 1.0E-34 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 454 470 1.0E-34 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 400 424 1.0E-34 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 294 309 1.0E-34 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 Pfam PF00027 Cyclic nucleotide-binding domain 62 150 1.4E-17 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 Gene3D G3DSA:2.60.120.10 47 164 1.6E-19 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 Gene3D G3DSA:3.50.50.60 366 579 2.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 261 571 1.9E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 Gene3D G3DSA:3.50.50.60 257 365 1.7E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 404 422 4.1E-25 T 17-03-2017 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 361 379 4.1E-25 T 17-03-2017 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 535 557 4.1E-25 T 17-03-2017 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 490 506 4.1E-25 T 17-03-2017 SHXM_RS19630 b2106e0690bdff6554536339912b933d 631 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 262 281 4.1E-25 T 17-03-2017 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 ProSitePatterns PS00145 Urease active site. 392 408 - T 17-03-2017 IPR017950 Urease active site GO:0009039 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 370 387 4.8E-13 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 409 425 4.8E-13 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Hamap MF_01953 Urease subunit alpha [ureC]. 24 683 48.972 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 SUPERFAMILY SSF51556 190 528 3.54E-152 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 SUPERFAMILY SSF51556 577 683 3.54E-152 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Pfam PF01979 Amidohydrolase family 186 542 8.5E-56 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Gene3D G3DSA:2.30.40.10 105 145 1.2E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Gene3D G3DSA:2.30.40.10 178 204 1.2E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 ProSitePatterns PS01120 Urease nickel ligands signature. 188 201 - T 17-03-2017 IPR029754 Urease nickel binding site GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Gene3D G3DSA:3.20.20.140 584 681 3.3E-168 T 17-03-2017 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Gene3D G3DSA:3.20.20.140 205 525 3.3E-168 T 17-03-2017 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 SUPERFAMILY SSF51338 505 574 7.6E-44 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 SUPERFAMILY SSF51338 26 144 7.6E-44 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47680 9109ed6462eaded8586894a6385f8348 683 Pfam PF00449 Urease alpha-subunit, N-terminal domain 25 147 9.6E-41 T 17-03-2017 IPR011612 Urease alpha-subunit, N-terminal domain KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 Pfam PF01926 50S ribosome-binding GTPase 277 395 5.5E-20 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 Pfam PF16360 GTP-binding GTPase Middle Region 182 269 1.9E-28 T 17-03-2017 IPR032305 GTP-binding protein, middle domain SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 SUPERFAMILY SSF52540 276 465 3.23E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 344 362 2.1E-6 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 277 297 2.1E-6 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 TIGRFAM TIGR03156 GTP_HflX: GTP-binding protein HflX 76 435 5.5E-129 T 17-03-2017 IPR016496 GTPase HflX GO:0005525 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 Pfam PF13167 GTP-binding GTPase N-terminal 92 180 5.9E-32 T 17-03-2017 IPR025121 GTPase HflX, N-terminal SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 PIRSF PIRSF006809 67 496 6.0E-157 T 17-03-2017 IPR016496 GTPase HflX GO:0005525 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 Hamap MF_00900 GTPase HflX [hflX]. 95 465 46.759 T 17-03-2017 IPR016496 GTPase HflX GO:0005525 SHXM_RS37355 43ad1aee96586acadd761f30f4f606f3 500 Gene3D G3DSA:3.40.50.300 275 438 1.6E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16530 9e1ab90e3536b470a655db36eae1474f 504 Pfam PF14224 Domain of unknown function (DUF4331) 37 437 5.9E-158 T 17-03-2017 IPR025566 Protein of unknown function DUF4331 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 155 167 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 Pfam PF00069 Protein kinase domain 31 282 8.8E-36 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 Gene3D G3DSA:1.10.510.10 101 292 1.4E-38 T 17-03-2017 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 SMART SM00220 31 290 6.9E-46 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 Gene3D G3DSA:3.30.200.20 24 100 1.3E-19 T 17-03-2017 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 37 60 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS03610 5a683f3c258a73bf09ed24ee8056c2e4 475 SUPERFAMILY SSF56112 25 306 7.28E-58 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS42365 b6375434713007ca9f9b01388766a389 373 Pfam PF16317 Glycosyl hydrolase family 99 56 368 4.1E-66 T 17-03-2017 IPR026071 Glycosyl hydrolase family 99 SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 Gene3D G3DSA:3.40.50.300 218 492 1.3E-119 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 Pfam PF00772 DnaB-like helicase N terminal domain 58 159 1.1E-36 T 17-03-2017 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 SMART SM00382 250 449 0.0018 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 TIGRFAM TIGR00665 DnaB: replicative DNA helicase 58 491 2.9E-167 T 17-03-2017 IPR007692 DNA helicase, DnaB type GO:0003677|GO:0003678|GO:0005524|GO:0006260 SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 SUPERFAMILY SSF48024 56 167 5.62E-39 T 17-03-2017 IPR007693 DNA helicase, DnaB-like, N-terminal GO:0003678|GO:0005524|GO:0006260 SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 Pfam PF03796 DnaB-like helicase C terminal domain 233 488 5.9E-109 T 17-03-2017 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 Reactome: R-HSA-2151201 SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 SUPERFAMILY SSF52540 231 482 3.78E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27965 6e1bacf0a0940cbf409095e785b1b106 493 Gene3D G3DSA:1.10.860.10 58 160 5.1E-42 T 17-03-2017 IPR016136 DNA helicase DnaB, N-terminal/DNA primase DnaG, C-terminal SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 Pfam PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 5 120 1.1E-34 T 17-03-2017 IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 Hamap MF_01576 Bifunctional protein FolD [folD]. 3 283 35.577 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 Gene3D G3DSA:3.40.50.720 139 264 1.4E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 154 174 1.7E-58 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 205 234 1.7E-58 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 256 274 1.7E-58 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 33 55 1.7E-58 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 74 101 1.7E-58 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 PRINTS PR00085 Tetrahydrofolate dehydrogenase/cyclohydrolase family signature 109 130 1.7E-58 T 17-03-2017 IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 SUPERFAMILY SSF53223 1 121 8.06E-37 T 17-03-2017 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 Gene3D G3DSA:3.40.192.10 7 138 2.4E-43 T 17-03-2017 SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 SUPERFAMILY SSF51735 122 282 7.53E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25260 32a5e20b88b645ae3f401846a069a683 295 Pfam PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 123 282 7.0E-59 T 17-03-2017 IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0003824|GO:0004488|GO:0009396|GO:0055114 KEGG: 00670+1.5.1.5+3.5.4.9|KEGG: 00720+1.5.1.5+3.5.4.9|MetaCyc: PWY-1722|MetaCyc: PWY-2201|MetaCyc: PWY-3841|MetaCyc: PWY-5030|MetaCyc: PWY-5497|MetaCyc: PWY-6613|Reactome: R-HSA-196757 SHXM_RS31265 e77f59030521b7bacab5490331d81b30 151 TIGRFAM TIGR01071 rplO_bact: ribosomal protein uL15 8 147 7.4E-45 T 17-03-2017 IPR005749 Ribosomal protein L15, bacterial-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31265 e77f59030521b7bacab5490331d81b30 151 ProSitePatterns PS00475 Ribosomal protein L15 signature. 114 144 - T 17-03-2017 IPR001196 Ribosomal protein L15, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31265 e77f59030521b7bacab5490331d81b30 151 Hamap MF_01341 50S ribosomal protein L15 [rplO]. 9 150 18.687 T 17-03-2017 IPR030878 Ribosomal protein L15 GO:0003735|GO:0006412|GO:0015934 SHXM_RS31265 e77f59030521b7bacab5490331d81b30 151 Pfam PF00828 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A 32 148 5.2E-33 T 17-03-2017 IPR021131 Ribosomal protein L18e/L15P SHXM_RS31265 e77f59030521b7bacab5490331d81b30 151 SUPERFAMILY SSF52080 10 149 2.62E-40 T 17-03-2017 IPR021131 Ribosomal protein L18e/L15P SHXM_RS31265 e77f59030521b7bacab5490331d81b30 151 Gene3D G3DSA:3.100.10.10 37 150 6.1E-32 T 17-03-2017 SHXM_RS04725 e16eafd22e553f26aab5cb446bd7905f 435 Gene3D G3DSA:3.40.190.10 325 370 7.9E-19 T 17-03-2017 SHXM_RS04725 e16eafd22e553f26aab5cb446bd7905f 435 Gene3D G3DSA:3.40.190.10 41 157 7.9E-19 T 17-03-2017 SHXM_RS04725 e16eafd22e553f26aab5cb446bd7905f 435 Gene3D G3DSA:3.40.190.10 159 324 8.1E-18 T 17-03-2017 SHXM_RS04725 e16eafd22e553f26aab5cb446bd7905f 435 Pfam PF01547 Bacterial extracellular solute-binding protein 64 315 1.5E-18 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS04725 e16eafd22e553f26aab5cb446bd7905f 435 SUPERFAMILY SSF53850 41 426 2.96E-47 T 17-03-2017 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 Hamap MF_00171 tRNA pseudouridine synthase A [truA]. 10 258 30.938 T 17-03-2017 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 SUPERFAMILY SSF55120 9 265 7.19E-72 T 17-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 Gene3D G3DSA:3.30.70.580 10 118 2.6E-34 T 17-03-2017 IPR020094 Pseudouridine synthase I, TruA, N-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 TIGRFAM TIGR00071 hisT_truA: tRNA pseudouridine(38-40) synthase 12 252 1.3E-50 T 17-03-2017 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 Gene3D G3DSA:3.30.70.660 120 256 3.6E-36 T 17-03-2017 IPR020095 Pseudouridine synthase I, TruA, C-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 PIRSF PIRSF001430 10 275 6.8E-74 T 17-03-2017 IPR001406 Pseudouridine synthase I, TruA GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 Pfam PF01416 tRNA pseudouridine synthase 18 116 2.2E-6 T 17-03-2017 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS31320 af3f569d48e5f49dae6a1bbac40ec039 288 Pfam PF01416 tRNA pseudouridine synthase 157 259 2.1E-22 T 17-03-2017 IPR020097 Pseudouridine synthase I, TruA, alpha/beta domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 TIGRFAM TIGR00198 cat_per_HPI: catalase/peroxidase HPI 33 742 0.0 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.420.10 595 717 1.2E-45 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 ProSitePatterns PS00435 Peroxidases proximal heme-ligand signature. 264 274 - T 17-03-2017 IPR019793 Peroxidases heam-ligand binding site Reactome: R-HSA-2408557 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 ProSitePatterns PS00436 Peroxidases active site signature. 100 111 - T 17-03-2017 IPR019794 Peroxidase, active site GO:0004601|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.420.10 315 414 3.5E-47 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.420.10 257 279 3.5E-47 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 SUPERFAMILY SSF48113 29 436 1.3E-156 T 17-03-2017 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Hamap MF_01961 Catalase-peroxidase [katG]. 15 742 42.327 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 SUPERFAMILY SSF48113 437 741 1.41E-111 T 17-03-2017 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.520.10 720 741 3.6E-63 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.520.10 244 256 6.7E-72 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.520.10 439 594 3.6E-63 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Gene3D G3DSA:1.10.520.10 57 211 6.7E-72 T 17-03-2017 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 272 295 1.7E-51 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 77 102 1.7E-51 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 36 58 1.7E-51 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 487 513 1.7E-51 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00460 Bacterial haem catalase-peroxidase signature 62 75 1.7E-51 T 17-03-2017 IPR000763 Catalase-peroxidase haem GO:0004096|GO:0004601|GO:0006979|GO:0020037|GO:0055114 KEGG: 00360+1.11.1.21|KEGG: 00380+1.11.1.21|KEGG: 00940+1.11.1.21|MetaCyc: PWY-5506 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Pfam PF00141 Peroxidase 409 716 1.7E-38 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 Pfam PF00141 Peroxidase 94 401 7.0E-48 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00458 Haem peroxidase superfamily signature 160 177 3.1E-19 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00458 Haem peroxidase superfamily signature 100 114 3.1E-19 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00458 Haem peroxidase superfamily signature 264 279 3.1E-19 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00458 Haem peroxidase superfamily signature 323 338 3.1E-19 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS11030 e7a7e71f5e358378edd5e411b0beadc0 742 PRINTS PR00458 Haem peroxidase superfamily signature 178 190 3.1E-19 T 17-03-2017 IPR002016 Haem peroxidase, plant/fungal/bacterial GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 3 386 1.1E-135 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 ProSitePatterns PS00737 Thiolases signature 2. 335 351 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 Gene3D G3DSA:3.40.47.10 138 189 7.1E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 Gene3D G3DSA:3.40.47.10 273 388 7.1E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 ProSitePatterns PS00098 Thiolases acyl-enzyme intermediate signature. 80 98 - T 17-03-2017 IPR020615 Thiolase, acyl-enzyme intermediate active site GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 Gene3D G3DSA:3.40.47.10 1 119 3.3E-71 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 Gene3D G3DSA:3.40.47.10 190 272 3.3E-71 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 Pfam PF00108 Thiolase, N-terminal domain 1 258 6.7E-97 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 ProSitePatterns PS00099 Thiolases active site. 370 383 - T 17-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 Pfam PF02803 Thiolase, C-terminal domain 267 387 6.1E-43 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 SUPERFAMILY SSF53901 268 387 8.83E-35 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 PIRSF PIRSF000429 1 390 6.7E-116 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS35375 272225429559ee72672cf56398d31d6f 392 SUPERFAMILY SSF53901 2 266 1.92E-83 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 Gene3D G3DSA:3.40.50.980 2 164 1.6E-26 T 17-03-2017 SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 Pfam PF13193 AMP-binding enzyme C-terminal domain 421 496 1.1E-17 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 SUPERFAMILY SSF56801 2 508 9.16E-132 T 17-03-2017 SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 Gene3D G3DSA:3.30.300.30 407 505 8.9E-30 T 17-03-2017 SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 Gene3D G3DSA:2.30.38.10 331 403 2.1E-23 T 17-03-2017 SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 Pfam PF00501 AMP-binding enzyme 7 412 1.7E-81 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS48590 00fdc52ad3ff535435c7bbd24b763a92 514 Gene3D G3DSA:3.40.50.980 165 316 3.0E-34 T 17-03-2017 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 Pfam PF01341 Glycosyl hydrolases family 6 57 303 2.3E-61 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 ProSitePatterns PS00656 Glycosyl hydrolases family 6 signature 2. 143 152 - T 17-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 SUPERFAMILY SSF51989 35 318 2.88E-80 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 55 74 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 126 141 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 282 296 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 212 222 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 182 195 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 247 260 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 261 281 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PRINTS PR00733 Glycosyl hydrolase family 6 signature 97 110 2.5E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 Gene3D G3DSA:3.20.20.40 35 318 4.9E-83 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS00900 3ae80a0941d1e28175a95685399fd8fd 321 PIRSF PIRSF001100 11 321 1.2E-103 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 Gene3D G3DSA:3.40.190.10 172 256 4.5E-6 T 17-03-2017 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 Gene3D G3DSA:3.40.190.10 100 171 1.4E-7 T 17-03-2017 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 Pfam PF03466 LysR substrate binding domain 91 275 2.9E-16 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 SUPERFAMILY SSF46785 3 85 4.31E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 64 2.3E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 8.5E-11 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 8.5E-11 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 8.5E-11 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 SUPERFAMILY SSF53850 91 288 8.14E-17 T 17-03-2017 SHXM_RS30295 f37c7113b4f2f7abe47a64cd2e23a684 300 Gene3D G3DSA:1.10.10.10 3 86 4.1E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 Gene3D G3DSA:1.10.10.10 4 69 1.3E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 Gene3D G3DSA:3.40.1410.10 70 235 1.0E-21 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 Pfam PF07702 UTRA domain 98 228 5.6E-16 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 SMART SM00866 93 231 3.0E-8 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 SMART SM00345 12 71 2.5E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 SUPERFAMILY SSF46785 4 81 2.16E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 45 61 6.6E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 31 45 6.6E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 SUPERFAMILY SSF64288 59 236 1.35E-25 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS46470 3d7090b9ead573e29adc1520773f2e14 243 Pfam PF00392 Bacterial regulatory proteins, gntR family 8 71 1.3E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS05635 575924a26f2c5c6535a619033efb3fd1 202 SMART SM00479 3 196 5.8E-9 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS05635 575924a26f2c5c6535a619033efb3fd1 202 Gene3D G3DSA:3.30.420.10 2 196 9.8E-28 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS05635 575924a26f2c5c6535a619033efb3fd1 202 SUPERFAMILY SSF53098 2 191 2.73E-17 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS05635 575924a26f2c5c6535a619033efb3fd1 202 Pfam PF00929 Exonuclease 5 185 3.7E-11 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS08625 7ad4a5da09e48428a04fd5e6d1605f88 142 Pfam PF14087 Domain of unknown function (DUF4267) 19 122 2.0E-18 T 17-03-2017 IPR025363 Protein of unknown function DUF4267 SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 Pfam PF01327 Polypeptide deformylase 26 181 2.0E-46 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 PIRSF PIRSF004749 14 204 2.5E-44 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 28 187 1.7E-39 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 PRINTS PR01576 Peptide deformylase signature 130 148 2.3E-34 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 PRINTS PR01576 Peptide deformylase signature 149 178 2.3E-34 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 PRINTS PR01576 Peptide deformylase signature 118 129 2.3E-34 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 PRINTS PR01576 Peptide deformylase signature 56 85 2.3E-34 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 SUPERFAMILY SSF56420 23 188 1.57E-52 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 Gene3D G3DSA:3.90.45.10 27 196 2.5E-56 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS27935 d30ff9bd0b85f80bf9f7f6bc91d32a02 212 Hamap MF_00163 Peptide deformylase [def]. 24 191 28.69 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 SUPERFAMILY SSF54373 228 331 6.67E-12 T 17-03-2017 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 Pfam PF01266 FAD dependent oxidoreductase 10 369 5.8E-66 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 SUPERFAMILY SSF51905 331 388 5.76E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 SUPERFAMILY SSF51905 9 228 5.76E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 Gene3D G3DSA:3.30.9.10 228 329 1.4E-16 T 17-03-2017 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 Gene3D G3DSA:3.30.9.10 91 144 1.4E-16 T 17-03-2017 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 Gene3D G3DSA:3.50.50.60 4 86 3.0E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 Gene3D G3DSA:3.50.50.60 145 227 3.0E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28730 a337a8b008f3db533a1bbd7538bf62a5 395 Gene3D G3DSA:3.50.50.60 331 389 3.0E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04920 c23c239600ae13a741327f4856ea4dad 187 SUPERFAMILY SSF48498 75 182 3.05E-19 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS04920 c23c239600ae13a741327f4856ea4dad 187 Gene3D G3DSA:1.10.357.10 2 183 2.8E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04920 c23c239600ae13a741327f4856ea4dad 187 SUPERFAMILY SSF46689 2 78 1.54E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04920 c23c239600ae13a741327f4856ea4dad 187 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 28 51 2.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04920 c23c239600ae13a741327f4856ea4dad 187 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 7 20 2.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04920 c23c239600ae13a741327f4856ea4dad 187 Pfam PF00440 Bacterial regulatory proteins, tetR family 7 53 4.0E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42485 5e9bd15e44c0aba0677895bc27e7a4f7 451 Gene3D G3DSA:3.30.590.10 121 438 3.4E-92 T 17-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 SHXM_RS42485 5e9bd15e44c0aba0677895bc27e7a4f7 451 SMART SM01230 117 368 7.9E-91 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS42485 5e9bd15e44c0aba0677895bc27e7a4f7 451 Pfam PF00120 Glutamine synthetase, catalytic domain 119 447 3.8E-97 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS42485 5e9bd15e44c0aba0677895bc27e7a4f7 451 SUPERFAMILY SSF54368 13 112 1.31E-11 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS42485 5e9bd15e44c0aba0677895bc27e7a4f7 451 Gene3D G3DSA:3.10.20.70 14 120 1.6E-11 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS42485 5e9bd15e44c0aba0677895bc27e7a4f7 451 SUPERFAMILY SSF55931 119 447 3.14E-97 T 17-03-2017 SHXM_RS30945 277d8fa23c4e049aa46f1c3a9fe749de 236 SUPERFAMILY SSF54862 35 142 1.67E-18 T 17-03-2017 SHXM_RS30945 277d8fa23c4e049aa46f1c3a9fe749de 236 Gene3D G3DSA:3.30.70.20 46 132 8.4E-16 T 17-03-2017 SHXM_RS30945 277d8fa23c4e049aa46f1c3a9fe749de 236 Pfam PF00037 4Fe-4S binding domain 94 114 5.3E-8 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS30945 277d8fa23c4e049aa46f1c3a9fe749de 236 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 50 61 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS30945 277d8fa23c4e049aa46f1c3a9fe749de 236 Hamap MF_01351 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic [ndhI]. 2 169 24.081 T 17-03-2017 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30945 277d8fa23c4e049aa46f1c3a9fe749de 236 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 99 110 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS43585 79d88564fb1604b9b875984168b616a0 200 SUPERFAMILY SSF48600 40 195 3.51E-35 T 17-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS43585 79d88564fb1604b9b875984168b616a0 200 PIRSF PIRSF026640 8 198 2.3E-45 T 17-03-2017 IPR008240 Chorismate mutase, periplasmic KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS43585 79d88564fb1604b9b875984168b616a0 200 TIGRFAM TIGR01806 CM_mono2: putative chorismate mutase 41 150 3.6E-29 T 17-03-2017 IPR008240 Chorismate mutase, periplasmic KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS43585 79d88564fb1604b9b875984168b616a0 200 Gene3D G3DSA:1.20.59.10 44 111 1.7E-11 T 17-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS43585 79d88564fb1604b9b875984168b616a0 200 Pfam PF01817 Chorismate mutase type II 44 111 3.6E-10 T 17-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS43585 79d88564fb1604b9b875984168b616a0 200 SMART SM00830 36 114 1.1E-16 T 17-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 Gene3D G3DSA:1.10.10.10 101 156 2.2E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 8 155 8.2E-16 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 Gene3D G3DSA:1.10.1740.10 4 97 7.4E-13 T 17-03-2017 SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 Pfam PF08281 Sigma-70, region 4 101 151 3.3E-11 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 SUPERFAMILY SSF88946 3 72 1.14E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 Pfam PF04542 Sigma-70 region 2 12 75 9.4E-11 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS11015 e886fe0a07fbe5f3b10b6029e5af74d0 163 SUPERFAMILY SSF88659 101 155 9.91E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS19755 a33fd738220225479675243f89a2d669 226 Gene3D G3DSA:3.40.50.150 52 184 4.1E-13 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS19755 a33fd738220225479675243f89a2d669 226 SUPERFAMILY SSF53335 50 205 5.19E-17 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS19755 a33fd738220225479675243f89a2d669 226 Pfam PF13578 Methyltransferase domain 53 181 1.4E-23 T 17-03-2017 SHXM_RS39130 adb2027ecd6566449192d0a8949b2694 605 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 399 592 6.1E-19 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS39130 adb2027ecd6566449192d0a8949b2694 605 SUPERFAMILY SSF52266 394 598 3.36E-40 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS39130 adb2027ecd6566449192d0a8949b2694 605 Gene3D G3DSA:3.40.50.1110 397 598 2.5E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS15580 59f112411c9664d4401bf6118e9c66dc 215 Gene3D G3DSA:3.20.20.70 4 214 3.7E-66 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS15580 59f112411c9664d4401bf6118e9c66dc 215 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 9 208 1.7E-47 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS15580 59f112411c9664d4401bf6118e9c66dc 215 SUPERFAMILY SSF51569 3 210 2.75E-54 T 17-03-2017 SHXM_RS15580 59f112411c9664d4401bf6118e9c66dc 215 Pfam PF01081 KDPG and KHG aldolase 9 200 1.8E-38 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 SMART SM00382 63 248 1.9E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 SUPERFAMILY SSF52540 305 523 7.36E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 ProSitePatterns PS00211 ABC transporters family signature. 437 451 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 Gene3D G3DSA:3.40.50.300 36 258 7.1E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 Gene3D G3DSA:3.40.50.300 286 529 1.7E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 SUPERFAMILY SSF52540 38 257 8.42E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 Pfam PF00005 ABC transporter 55 200 8.6E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS24860 83120e691000778f4b083ad2cb4353f5 557 Pfam PF00005 ABC transporter 308 464 2.3E-17 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS13710 2c887693c5aa35317cc2b495e8c7f28e 280 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 97 277 1.6E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13710 2c887693c5aa35317cc2b495e8c7f28e 280 SUPERFAMILY SSF161098 74 261 3.43E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13710 2c887693c5aa35317cc2b495e8c7f28e 280 Gene3D G3DSA:1.10.3720.10 73 276 2.7E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 239 379 1.7E-15 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 SUPERFAMILY SSF56645 31 220 8.51E-37 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 Gene3D G3DSA:1.10.540.10 3 112 2.7E-15 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 Gene3D G3DSA:2.40.110.10 132 213 8.5E-20 T 17-03-2017 SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 132 212 3.7E-9 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 SUPERFAMILY SSF47203 235 398 3.06E-19 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS01990 5b5f3d4b95aa6bfc2d3688e37b81e5a0 404 Gene3D G3DSA:1.20.140.10 214 400 1.0E-48 T 17-03-2017 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 Pfam PF04055 Radical SAM superfamily 101 256 1.1E-11 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 SMART SM00729 91 297 7.1E-37 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 Gene3D G3DSA:3.20.20.70 54 358 9.7E-87 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 TIGRFAM TIGR00433 bioB: biotin synthase 64 357 1.2E-112 T 17-03-2017 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 Pfam PF06968 Biotin and Thiamin Synthesis associated domain 268 357 4.4E-14 T 17-03-2017 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 SUPERFAMILY SSF102114 54 357 2.35E-74 T 17-03-2017 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 Hamap MF_01694 Biotin synthase [bioB]. 51 359 39.274 T 17-03-2017 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS48575 4674179f2136a63d82ed47fc4705f425 444 SMART SM00876 268 358 4.3E-32 T 17-03-2017 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS02065 a3dc96ba611585fc1af109caa19604aa 312 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 177 188 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS02065 a3dc96ba611585fc1af109caa19604aa 312 Pfam PF00480 ROK family 30 308 6.6E-28 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS02065 a3dc96ba611585fc1af109caa19604aa 312 Gene3D G3DSA:3.30.420.40 154 289 1.0E-25 T 17-03-2017 SHXM_RS02065 a3dc96ba611585fc1af109caa19604aa 312 SUPERFAMILY SSF53067 29 309 2.06E-28 T 17-03-2017 SHXM_RS02065 a3dc96ba611585fc1af109caa19604aa 312 Gene3D G3DSA:3.30.420.40 22 153 8.1E-21 T 17-03-2017 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 378 484 3.0E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 SUPERFAMILY SSF158472 220 268 6.15E-7 T 17-03-2017 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 Gene3D G3DSA:1.10.287.130 264 323 1.2E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 SMART SM00304 218 271 5.4E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 SUPERFAMILY SSF47384 255 337 4.12E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 SMART SM00387 376 486 1.5E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 Pfam PF00672 HAMP domain 205 268 5.3E-11 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 Gene3D G3DSA:3.30.565.10 324 485 4.6E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 SMART SM00388 272 337 2.8E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 SUPERFAMILY SSF55874 327 484 9.04E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 PRINTS PR00344 Bacterial sensor protein C-terminal signature 446 464 3.5E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 PRINTS PR00344 Bacterial sensor protein C-terminal signature 429 439 3.5E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 PRINTS PR00344 Bacterial sensor protein C-terminal signature 411 425 3.5E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 PRINTS PR00344 Bacterial sensor protein C-terminal signature 470 483 3.5E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20680 2cdaa3168ca6088aa628b1a8869b627a 490 Pfam PF00512 His Kinase A (phospho-acceptor) domain 273 336 9.9E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07530 3ace943c167e014cc0df23aa76dcacdd 452 Pfam PF00120 Glutamine synthetase, catalytic domain 121 438 3.7E-72 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS07530 3ace943c167e014cc0df23aa76dcacdd 452 SUPERFAMILY SSF55931 119 438 1.24E-77 T 17-03-2017 SHXM_RS07530 3ace943c167e014cc0df23aa76dcacdd 452 SUPERFAMILY SSF54368 19 117 2.22E-5 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS07530 3ace943c167e014cc0df23aa76dcacdd 452 Gene3D G3DSA:3.30.590.10 123 438 1.0E-84 T 17-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 SHXM_RS07530 3ace943c167e014cc0df23aa76dcacdd 452 SMART SM01230 119 369 4.1E-65 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SMART SM00065 283 460 3.5E-13 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 30 129 8.9E-13 T 17-03-2017 IPR000014 PAS domain SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 505 686 4.0E-50 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Gene3D G3DSA:3.30.450.20 146 257 1.2E-15 T 17-03-2017 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SUPERFAMILY SSF55785 25 129 5.06E-18 T 17-03-2017 IPR000014 PAS domain SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SUPERFAMILY SSF55781 354 463 1.35E-19 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SUPERFAMILY SSF81606 492 686 1.8E-5 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SUPERFAMILY SSF55785 144 256 2.79E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Gene3D G3DSA:3.30.450.40 276 458 7.5E-38 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Pfam PF00989 PAS fold 26 125 6.3E-10 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Pfam PF08448 PAS fold 148 260 1.3E-21 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Gene3D G3DSA:3.30.450.20 25 129 5.9E-20 T 17-03-2017 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SMART SM00091 141 207 0.0044 T 17-03-2017 IPR000014 PAS domain SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SMART SM00091 20 87 6.0E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 Pfam PF01590 GAF domain 294 450 4.2E-13 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS08310 3675f45c54303ce75d9ba71ce488ad6e 702 SMART SM00331 478 686 8.8E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 273 287 2.3E-45 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 208 228 2.3E-45 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 249 272 2.3E-45 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 229 246 2.3E-45 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 150 164 2.3E-45 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 Gene3D G3DSA:2.40.10.10 124 203 4.2E-26 T 17-03-2017 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 PIRSF PIRSF001134 3 308 1.4E-83 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 Gene3D G3DSA:2.40.10.10 204 295 7.2E-33 T 17-03-2017 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 152 157 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 258 269 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 SUPERFAMILY SSF50494 132 301 2.66E-40 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS05090 96673ff83006ac80b724633f066981e3 308 Pfam PF00089 Trypsin 150 300 4.2E-9 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS31520 06127a591cf0779a296686b640e81b3b 469 Pfam PF02458 Transferase family 20 441 9.5E-53 T 17-03-2017 IPR003480 Transferase GO:0016747 SHXM_RS31520 06127a591cf0779a296686b640e81b3b 469 SUPERFAMILY SSF52777 39 175 1.33E-10 T 17-03-2017 SHXM_RS31520 06127a591cf0779a296686b640e81b3b 469 Gene3D G3DSA:3.30.559.10 22 190 1.7E-35 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS31520 06127a591cf0779a296686b640e81b3b 469 Gene3D G3DSA:3.30.559.10 228 441 1.3E-36 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS24425 764ef862d22f6bfe9ae03043776fbafb 407 SMART SM00382 27 213 7.2E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS24425 764ef862d22f6bfe9ae03043776fbafb 407 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS24425 764ef862d22f6bfe9ae03043776fbafb 407 Gene3D G3DSA:3.40.50.300 314 378 0.001 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24425 764ef862d22f6bfe9ae03043776fbafb 407 SUPERFAMILY SSF52540 1 239 2.99E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24425 764ef862d22f6bfe9ae03043776fbafb 407 Pfam PF00005 ABC transporter 19 163 4.0E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS24425 764ef862d22f6bfe9ae03043776fbafb 407 Gene3D G3DSA:3.40.50.300 1 237 3.1E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47170 ab00f21dd03c22e531860438c365bd81 400 Gene3D G3DSA:3.40.50.720 4 135 6.1E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47170 ab00f21dd03c22e531860438c365bd81 400 SUPERFAMILY SSF55347 127 272 2.29E-7 T 17-03-2017 SHXM_RS47170 ab00f21dd03c22e531860438c365bd81 400 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 4 121 3.7E-16 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS47170 ab00f21dd03c22e531860438c365bd81 400 SUPERFAMILY SSF51735 4 154 9.21E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47170 ab00f21dd03c22e531860438c365bd81 400 Gene3D G3DSA:3.30.360.10 136 302 4.9E-8 T 17-03-2017 SHXM_RS47170 ab00f21dd03c22e531860438c365bd81 400 Gene3D G3DSA:3.30.360.10 337 385 4.9E-8 T 17-03-2017 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 PRINTS PR00783 Major intrinsic protein family signature 75 99 1.1E-18 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 PRINTS PR00783 Major intrinsic protein family signature 230 250 1.1E-18 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 PRINTS PR00783 Major intrinsic protein family signature 112 131 1.1E-18 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 PRINTS PR00783 Major intrinsic protein family signature 193 215 1.1E-18 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 Gene3D G3DSA:1.20.1080.10 32 248 1.9E-34 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 Pfam PF00230 Major intrinsic protein 41 242 4.1E-27 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 ProSitePatterns PS00221 MIP family signature. 93 101 - T 17-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS41530 d5e1d3a4d7f556a4a8b4297c7515ce2d 329 SUPERFAMILY SSF81338 33 252 6.15E-33 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS17315 aac18b7c8ef41db0c84e59c360ffde43 163 Pfam PF01047 MarR family 45 99 5.8E-17 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS17315 aac18b7c8ef41db0c84e59c360ffde43 163 Gene3D G3DSA:1.10.10.10 18 149 3.5E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17315 aac18b7c8ef41db0c84e59c360ffde43 163 SMART SM00347 35 135 6.2E-19 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS17315 aac18b7c8ef41db0c84e59c360ffde43 163 SUPERFAMILY SSF46785 19 149 1.96E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Gene3D G3DSA:3.40.228.10 157 339 4.5E-54 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Gene3D G3DSA:2.40.40.20 607 758 2.4E-49 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Gene3D G3DSA:2.20.25.90 17 74 1.7E-13 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 SUPERFAMILY SSF50692 609 758 2.22E-44 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Pfam PF00384 Molybdopterin oxidoreductase 79 505 1.7E-72 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Pfam PF01568 Molydopterin dinucleotide binding domain 648 754 1.6E-29 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 SUPERFAMILY SSF53706 16 562 4.84E-158 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 SUPERFAMILY SSF53706 615 632 4.84E-158 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 SMART SM00926 14 76 7.8E-7 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Gene3D G3DSA:3.40.50.740 340 549 9.7E-78 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Gene3D G3DSA:3.40.50.740 79 156 9.7E-78 T 17-03-2017 SHXM_RS20625 c613d2507485d729b34b9963f4b89006 762 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 17 72 3.0E-10 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 Pfam PF13193 AMP-binding enzyme C-terminal domain 402 477 6.4E-15 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 ProSitePatterns PS00455 Putative AMP-binding domain signature. 154 165 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 Gene3D G3DSA:3.40.50.980 160 314 1.8E-22 T 17-03-2017 SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 Gene3D G3DSA:2.30.38.10 315 387 2.6E-13 T 17-03-2017 SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 SUPERFAMILY SSF56801 4 489 1.16E-115 T 17-03-2017 SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 Gene3D G3DSA:3.30.300.30 388 486 8.2E-26 T 17-03-2017 SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 Gene3D G3DSA:3.40.50.980 5 159 1.9E-28 T 17-03-2017 SHXM_RS45835 6865863d1ab0df3ba3263c1b937b2da5 505 Pfam PF00501 AMP-binding enzyme 12 393 1.4E-64 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 Gene3D G3DSA:1.20.1250.20 228 417 1.0E-8 T 17-03-2017 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 SUPERFAMILY SSF103473 22 419 1.96E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 TIGRFAM TIGR00710 efflux_Bcr_CflA: drug resistance transporter, Bcr/CflA subfamily 28 412 2.0E-103 T 17-03-2017 IPR004812 Drug resistance transporter Bcr/CmlA subfamily GO:0005215|GO:0006810|GO:0016021 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 PRINTS PR01035 Tetracycline resistance protein signature 96 120 4.1E-5 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 PRINTS PR01035 Tetracycline resistance protein signature 39 55 4.1E-5 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 PRINTS PR01035 Tetracycline resistance protein signature 309 329 4.1E-5 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 PRINTS PR01035 Tetracycline resistance protein signature 123 144 4.1E-5 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 Pfam PF07690 Major Facilitator Superfamily 41 379 1.8E-41 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 Gene3D G3DSA:1.20.1250.20 36 212 8.7E-29 T 17-03-2017 SHXM_RS19550 d0b4ff0035a50ab091b54e07bf275e94 427 ProSitePatterns PS00216 Sugar transport proteins signature 1. 83 99 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 SUPERFAMILY SSF52540 2 216 1.12E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 Gene3D G3DSA:3.40.50.300 445 532 1.5E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 Gene3D G3DSA:3.40.50.300 2 205 1.7E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 SUPERFAMILY SSF52540 7 46 2.41E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 SUPERFAMILY SSF52540 335 522 2.41E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 PIRSF PIRSF003128 1 571 3.5E-156 T 17-03-2017 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 Pfam PF02463 RecF/RecN/SMC N terminal domain 12 526 4.2E-16 T 17-03-2017 IPR003395 RecF/RecN/SMC, N-terminal SHXM_RS17125 560914ced66b1e5e6c1d88b662ba3d04 573 TIGRFAM TIGR00634 recN: DNA repair protein RecN 1 568 1.3E-161 T 17-03-2017 IPR004604 DNA recombination/repair protein RecN GO:0005524|GO:0006281|GO:0006310 SHXM_RS27310 80d6c35895ce15a6da50d967f97a6359 211 Hamap MF_01218_B Uracil phosphoribosyltransferase [upp]. 2 210 43.703 T 17-03-2017 IPR005765 Uracil phosphoribosyl transferase GO:0004845|GO:0006223 KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 SHXM_RS27310 80d6c35895ce15a6da50d967f97a6359 211 TIGRFAM TIGR01091 upp: uracil phosphoribosyltransferase 3 209 1.5E-76 T 17-03-2017 IPR005765 Uracil phosphoribosyl transferase GO:0004845|GO:0006223 KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 SHXM_RS27310 80d6c35895ce15a6da50d967f97a6359 211 Gene3D G3DSA:3.40.50.2020 2 209 6.6E-74 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS27310 80d6c35895ce15a6da50d967f97a6359 211 Pfam PF14681 Uracil phosphoribosyltransferase 5 208 1.1E-64 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS27310 80d6c35895ce15a6da50d967f97a6359 211 SUPERFAMILY SSF53271 3 208 6.03E-64 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Gene3D G3DSA:2.60.120.360 1062 1168 1.1E-11 T 17-03-2017 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Gene3D G3DSA:2.60.120.360 821 923 3.3E-5 T 17-03-2017 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 SUPERFAMILY SSF49785 823 923 9.35E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 SUPERFAMILY SSF49785 1074 1171 3.06E-9 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Pfam PF03648 Glycosyl hydrolase family 67 N-terminus 48 167 6.3E-15 T 17-03-2017 IPR005154 Alpha glucuronidase, N-terminal GO:0045493|GO:0046559 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Pfam PF07488 Glycosyl hydrolase family 67 middle domain 171 492 7.2E-126 T 17-03-2017 IPR011100 Glycosyl hydrolase family 67, catalytic domain GO:0005576|GO:0045493|GO:0046559 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Pfam PF07477 Glycosyl hydrolase family 67 C-terminus 493 710 4.0E-68 T 17-03-2017 IPR011099 Glycosyl hydrolase family 67, C-terminal GO:0005576|GO:0045493|GO:0046559 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Gene3D G3DSA:3.30.379.10 44 183 9.9E-28 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 SUPERFAMILY SSF51445 189 710 2.81E-192 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Gene3D G3DSA:3.20.20.80 188 513 1.1E-131 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 SUPERFAMILY SSF55545 43 187 5.75E-25 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS01830 6b264e43e85231ae8901b0e8242a372d 1218 Gene3D G3DSA:3.90.1330.10 516 711 1.3E-62 T 17-03-2017 IPR011099 Glycosyl hydrolase family 67, C-terminal GO:0005576|GO:0045493|GO:0046559 SHXM_RS11695 c300fb7e480be45b4829f2b0c62a2af7 435 SUPERFAMILY SSF53850 31 426 2.66E-54 T 17-03-2017 SHXM_RS11695 c300fb7e480be45b4829f2b0c62a2af7 435 Pfam PF01547 Bacterial extracellular solute-binding protein 64 339 4.2E-29 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS11695 c300fb7e480be45b4829f2b0c62a2af7 435 Gene3D G3DSA:3.40.190.10 42 172 1.4E-11 T 17-03-2017 SHXM_RS11695 c300fb7e480be45b4829f2b0c62a2af7 435 Gene3D G3DSA:3.40.190.10 173 359 6.1E-44 T 17-03-2017 SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 Gene3D G3DSA:3.40.50.980 12 142 1.6E-17 T 17-03-2017 SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 Gene3D G3DSA:3.30.300.30 376 471 2.2E-12 T 17-03-2017 SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 Gene3D G3DSA:2.30.38.10 298 374 4.2E-16 T 17-03-2017 SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 Pfam PF00501 AMP-binding enzyme 12 374 2.9E-59 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 SUPERFAMILY SSF56801 10 472 5.36E-86 T 17-03-2017 SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 ProSitePatterns PS00455 Putative AMP-binding domain signature. 135 146 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS45390 b5d4622aec92996bcb64a5e6675c9d86 478 Gene3D G3DSA:3.40.50.980 143 293 2.9E-28 T 17-03-2017 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Pfam PF00069 Protein kinase domain 16 262 1.2E-37 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SUPERFAMILY SSF56112 12 307 2.16E-62 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 22 44 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Gene3D G3DSA:3.30.200.20 7 82 1.3E-12 T 17-03-2017 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Gene3D G3DSA:2.140.10.10 559 864 1.0E-64 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Gene3D G3DSA:2.140.10.10 499 525 1.0E-64 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SUPERFAMILY SSF50998 718 866 1.65E-27 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 629 660 0.0027 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 760 791 13.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 674 705 0.28 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 513 542 12.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 720 751 1.3E-5 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 839 871 1.3 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 799 831 0.86 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 547 578 25.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00564 585 617 2.2 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SMART SM00220 16 271 2.8E-40 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Pfam PF13570 PQQ-like domain 501 534 3.9E-4 T 17-03-2017 IPR025666 Pyrrolo-quinoline quinone-like domain SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 SUPERFAMILY SSF50998 546 752 1.12E-34 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 134 146 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Gene3D G3DSA:1.10.510.10 99 263 2.3E-40 T 17-03-2017 SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Pfam PF13360 PQQ-like domain 719 865 1.0E-19 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS31780 b41ff14ffa00df3d31f67fa2a64b901a 875 Pfam PF13360 PQQ-like domain 549 704 1.8E-20 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS19945 0af97feafb038f949c548f00ec9ab67e 65 Gene3D G3DSA:3.30.70.20 1 64 4.3E-15 T 17-03-2017 SHXM_RS19945 0af97feafb038f949c548f00ec9ab67e 65 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 4.7E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS19945 0af97feafb038f949c548f00ec9ab67e 65 PRINTS PR00352 3Fe-4S ferredoxin signature 16 26 4.7E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS19945 0af97feafb038f949c548f00ec9ab67e 65 PRINTS PR00352 3Fe-4S ferredoxin signature 5 16 4.7E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS19945 0af97feafb038f949c548f00ec9ab67e 65 SUPERFAMILY SSF54862 2 63 8.14E-13 T 17-03-2017 SHXM_RS19945 0af97feafb038f949c548f00ec9ab67e 65 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 5 62 4.2E-14 T 17-03-2017 SHXM_RS00305 d2bbcfbc4e319cac5c59dfed70957587 224 SUPERFAMILY SSF81901 88 154 3.79E-5 T 17-03-2017 SHXM_RS00305 d2bbcfbc4e319cac5c59dfed70957587 224 Gene3D G3DSA:1.25.40.10 88 155 4.2E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10485 d68a6dd45e386aec16466b8db6f08f0f 506 SUPERFAMILY SSF103473 25 486 1.83E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS10485 d68a6dd45e386aec16466b8db6f08f0f 506 Pfam PF00083 Sugar (and other) transporter 79 487 8.4E-44 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS10485 d68a6dd45e386aec16466b8db6f08f0f 506 Gene3D G3DSA:1.20.1250.20 73 230 3.6E-26 T 17-03-2017 SHXM_RS10485 d68a6dd45e386aec16466b8db6f08f0f 506 Gene3D G3DSA:1.20.1250.20 288 482 1.2E-15 T 17-03-2017 SHXM_RS38580 0a56336e50a840f4cc138362534e245d 299 Gene3D G3DSA:3.90.1200.10 101 259 1.2E-13 T 17-03-2017 SHXM_RS38580 0a56336e50a840f4cc138362534e245d 299 SUPERFAMILY SSF56112 1 270 1.45E-31 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS38580 0a56336e50a840f4cc138362534e245d 299 Pfam PF01636 Phosphotransferase enzyme family 31 244 5.4E-14 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 Pfam PF08482 ATP-dependent helicase C-terminal 730 863 5.3E-49 T 17-03-2017 IPR013689 ATP-dependent RNA helicase HrpB, C-terminal SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 SMART SM00490 276 376 5.2E-11 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 SMART SM00847 436 529 4.5E-14 T 17-03-2017 IPR007502 Helicase-associated domain GO:0004386 SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 Gene3D G3DSA:3.40.50.300 26 186 2.2E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 PIRSF PIRSF005496 22 876 1.4E-260 T 17-03-2017 IPR010225 RNA helicase, ATP-dependent DEAH box, HrpB-type SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 Pfam PF00271 Helicase conserved C-terminal domain 254 374 4.3E-11 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 SUPERFAMILY SSF52540 39 187 1.23E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 SUPERFAMILY SSF52540 229 386 1.23E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 Gene3D G3DSA:3.40.50.300 248 390 8.3E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 Pfam PF04408 Helicase associated domain (HA2) 437 509 2.7E-11 T 17-03-2017 IPR007502 Helicase-associated domain GO:0004386 SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 Pfam PF00270 DEAD/DEAH box helicase 31 185 9.4E-6 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 TIGRFAM TIGR01970 DEAH_box_HrpB: ATP-dependent helicase HrpB 27 875 4.3E-226 T 17-03-2017 IPR010225 RNA helicase, ATP-dependent DEAH box, HrpB-type SHXM_RS18100 c8dfe1c9eae7541b43515d0f33aa191d 876 SMART SM00487 15 226 6.7E-19 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS27505 7e839e9d9c5eddd270dd8a503c1c9585 153 SUPERFAMILY SSF55874 41 133 7.8E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27505 7e839e9d9c5eddd270dd8a503c1c9585 153 Pfam PF13581 Histidine kinase-like ATPase domain 47 129 2.1E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27505 7e839e9d9c5eddd270dd8a503c1c9585 153 Gene3D G3DSA:3.30.565.10 49 135 1.3E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 283 1.7E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Gene3D G3DSA:3.40.47.10 36 295 1.0E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 196 212 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Pfam PF00698 Acyl transferase domain 557 624 7.9E-20 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 409 522 2.6E-17 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 SUPERFAMILY SSF101173 4 34 7.19E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Gene3D G3DSA:3.40.47.10 296 461 6.6E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Pfam PF08990 Erythronolide synthase docking 3 27 2.6E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 SUPERFAMILY SSF53901 30 404 3.25E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Gene3D G3DSA:3.40.366.10 546 624 5.4E-18 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 SMART SM00825 Beta-ketoacyl synthase 36 459 7.9E-218 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 291 406 6.0E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05385 7e3b6484601086ef0f164a21b8d123be 625 SUPERFAMILY SSF52151 556 625 3.66E-15 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 Pfam PF13581 Histidine kinase-like ATPase domain 680 788 3.3E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 474 666 2.6E-50 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 Gene3D G3DSA:3.30.450.40 242 424 4.1E-29 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 SMART SM00331 445 666 7.8E-50 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 Gene3D G3DSA:3.30.450.20 1 43 3.1E-8 T 17-03-2017 SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 SUPERFAMILY SSF81606 461 666 4.84E-12 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 SUPERFAMILY SSF55874 700 791 1.68E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 SUPERFAMILY SSF55781 316 427 1.64E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 Gene3D G3DSA:3.60.40.10 588 664 3.6E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14685 46a2bd0cfff68f0edeed35b120ef5f76 800 SUPERFAMILY SSF55785 1 53 1.12E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 TIGRFAM TIGR01050 rpsS_bact: ribosomal protein uS19 1 92 9.3E-47 T 17-03-2017 IPR005732 Ribosomal protein S19, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 PIRSF PIRSF002144 1 93 2.0E-30 T 17-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 PRINTS PR00975 Ribosomal protein S19 family signature 65 80 1.4E-23 T 17-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 PRINTS PR00975 Ribosomal protein S19 family signature 33 52 1.4E-23 T 17-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 PRINTS PR00975 Ribosomal protein S19 family signature 53 65 1.4E-23 T 17-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 Gene3D G3DSA:3.30.860.10 1 92 1.7E-40 T 17-03-2017 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 ProSitePatterns PS00323 Ribosomal protein S19 signature. 53 77 - T 17-03-2017 IPR020934 Ribosomal protein S19 conserved site GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 Hamap MF_00531 30S ribosomal protein S19 [rpsS]. 1 89 24.98 T 17-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 Pfam PF00203 Ribosomal protein S19 3 83 8.5E-36 T 17-03-2017 IPR002222 Ribosomal protein S19/S15 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31185 dd01bf306d34b03648aa0db16c1cca25 93 SUPERFAMILY SSF54570 3 85 8.11E-35 T 17-03-2017 IPR023575 Ribosomal protein S19, superfamily GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 8.0E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 8.0E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 SUPERFAMILY SSF48498 96 237 4.0E-21 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 94 236 4.4E-9 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 66 2.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 Gene3D G3DSA:1.10.10.60 3 72 8.9E-25 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 Gene3D G3DSA:1.10.357.10 93 238 4.3E-58 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS17725 e5325664ec5d3313590505424ae7fece 242 SUPERFAMILY SSF46689 10 73 3.95E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 SUPERFAMILY SSF52210 226 372 5.1E-42 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 Pfam PF08442 ATP-grasp domain 2 191 8.8E-65 T 17-03-2017 IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 TIGRFAM TIGR01016 sucCoAbeta: succinate-CoA ligase, beta subunit 1 373 3.9E-118 T 17-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 Pfam PF00549 CoA-ligase 251 342 3.5E-11 T 17-03-2017 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 ProSitePatterns PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 244 268 - T 17-03-2017 IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 Gene3D G3DSA:3.30.1490.20 23 86 1.3E-17 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 PIRSF PIRSF001554 1 374 9.8E-127 T 17-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 SUPERFAMILY SSF56059 1 217 1.61E-62 T 17-03-2017 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 Hamap MF_00558 Succinyl-CoA ligase [ADP-forming] subunit beta [sucC]. 1 374 38.288 T 17-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 Gene3D G3DSA:3.30.470.20 87 220 2.2E-46 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS14115 8ec2d7a6231ca55acb039b64af7d2cd3 374 Gene3D G3DSA:3.40.50.261 227 373 1.3E-49 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 Gene3D G3DSA:3.40.50.720 172 287 1.1E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 137 4.1E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 SUPERFAMILY SSF50129 4 178 2.59E-49 T 17-03-2017 IPR011032 GroES-like SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 SMART SM00829 9 339 0.0067 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 SUPERFAMILY SSF51735 148 303 4.4E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 Gene3D G3DSA:3.90.180.10 4 171 7.0E-49 T 17-03-2017 IPR011032 GroES-like SHXM_RS24980 f1261dcb961ba3332a6e928572508993 343 Pfam PF00107 Zinc-binding dehydrogenase 180 303 6.1E-16 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 ProSitePatterns PS01081 TetR-type HTH domain signature. 42 72 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 SUPERFAMILY SSF46689 17 88 1.59E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 Gene3D G3DSA:1.10.357.10 69 212 7.7E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 Gene3D G3DSA:1.10.10.60 13 68 5.7E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 30 43 1.8E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 51 74 1.8E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20250 b1214223025ccabf0998f9c4534e56bc 221 Pfam PF00440 Bacterial regulatory proteins, tetR family 31 74 6.9E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 Gene3D G3DSA:3.50.50.60 5 110 6.2E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 SUPERFAMILY SSF51905 222 347 2.05E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 SUPERFAMILY SSF51905 5 132 2.05E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 SUPERFAMILY SSF51905 161 179 2.05E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 328 4.9E-62 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 162 180 3.4E-10 T 17-03-2017 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 102 120 3.4E-10 T 17-03-2017 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 3.4E-10 T 17-03-2017 SHXM_RS07145 be52383ffb612757c42b6bf93849436d 439 Gene3D G3DSA:3.50.50.60 111 336 8.1E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39590 75ee68a7691d8c766c42bb376a7e3507 353 SUPERFAMILY SSF56784 7 109 5.79E-15 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS39590 75ee68a7691d8c766c42bb376a7e3507 353 Gene3D G3DSA:3.40.50.1000 5 113 5.4E-20 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS39590 75ee68a7691d8c766c42bb376a7e3507 353 SUPERFAMILY SSF55729 184 304 5.74E-7 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS39590 75ee68a7691d8c766c42bb376a7e3507 353 TIGRFAM TIGR01686 FkbH: FkbH domain 5 314 2.0E-110 T 17-03-2017 IPR010037 FkbH domain SHXM_RS39590 75ee68a7691d8c766c42bb376a7e3507 353 TIGRFAM TIGR01681 HAD-SF-IIIC: HAD phosphatase, family IIIC 8 118 7.8E-17 T 17-03-2017 IPR010033 HAD-superfamily phosphatase, subfamily IIIC SHXM_RS39590 75ee68a7691d8c766c42bb376a7e3507 353 Gene3D G3DSA:3.40.630.30 184 314 1.1E-7 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Pfam PF13538 UvrD-like helicase C-terminal domain 658 706 1.5E-19 T 17-03-2017 IPR027785 UvrD-like helicase C-terminal domain SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Pfam PF14520 Helix-hairpin-helix domain 94 143 2.8E-7 T 17-03-2017 SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 TIGRFAM TIGR01448 recD_rel: helicase, RecD/TraA family 8 731 4.1E-201 T 17-03-2017 IPR006345 DNA helicase, RecD-like GO:0003677|GO:0032508|GO:0043141 SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Hamap MF_01488 ATP-dependent RecD-like DNA helicase [recD2]. 4 744 29.332 T 17-03-2017 IPR006345 DNA helicase, RecD-like GO:0003677|GO:0032508|GO:0043141 SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 SUPERFAMILY SSF52540 184 262 6.39E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 SUPERFAMILY SSF52540 332 483 6.39E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 SUPERFAMILY SSF47781 86 162 5.68E-10 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 SUPERFAMILY SSF52540 553 719 2.41E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 SUPERFAMILY SSF52540 445 512 2.41E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Gene3D G3DSA:3.40.50.300 646 710 1.8E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Gene3D G3DSA:1.10.150.20 94 162 8.1E-4 T 17-03-2017 SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Pfam PF14490 Helix-hairpin-helix containing domain 144 234 6.7E-32 T 17-03-2017 IPR029493 RecD helicase-like helix-hairpin-helix domain SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Pfam PF13604 AAA domain 336 514 1.6E-44 T 17-03-2017 SHXM_RS22320 b100a382125cb4ce0002d32bb9885e0f 747 Gene3D G3DSA:3.40.50.300 321 511 1.9E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SUPERFAMILY SSF81296 354 432 9.5E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SUPERFAMILY SSF81296 20 99 2.43E-15 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Pfam PF01833 IPT/TIG domain 271 350 2.6E-12 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Pfam PF01833 IPT/TIG domain 103 179 6.5E-12 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Pfam PF01833 IPT/TIG domain 436 511 3.1E-10 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Pfam PF01833 IPT/TIG domain 187 263 1.1E-8 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Pfam PF01833 IPT/TIG domain 354 432 3.8E-9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Pfam PF01833 IPT/TIG domain 21 99 2.8E-11 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SUPERFAMILY SSF81296 270 351 4.76E-15 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SMART SM00429 353 433 0.0014 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SMART SM00429 102 182 3.9E-9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SMART SM00429 20 100 3.0E-7 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SMART SM00429 435 513 0.5 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SMART SM00429 270 351 5.5E-6 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SMART SM00429 186 266 0.012 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SUPERFAMILY SSF81296 186 262 1.29E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SUPERFAMILY SSF81296 102 177 1.0E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Gene3D G3DSA:2.60.40.10 102 181 3.2E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Gene3D G3DSA:2.60.40.10 187 265 2.4E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Gene3D G3DSA:2.60.40.10 271 350 2.2E-17 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Gene3D G3DSA:2.60.40.10 354 432 1.9E-14 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Gene3D G3DSA:2.60.40.10 436 513 9.2E-17 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 Gene3D G3DSA:2.60.40.10 19 99 1.8E-17 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31970 82cbb787675f837d94b74c790cf7674d 520 SUPERFAMILY SSF81296 435 513 1.17E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 Gene3D G3DSA:3.40.50.720 169 279 4.9E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 134 8.4E-25 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 SMART SM00829 11 333 0.0072 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 Gene3D G3DSA:3.90.180.10 3 168 2.1E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 Pfam PF00107 Zinc-binding dehydrogenase 175 296 7.8E-20 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 SUPERFAMILY SSF50129 5 173 3.24E-48 T 17-03-2017 IPR011032 GroES-like SHXM_RS44755 26635de7810ad6d025a93c2133fada4f 335 SUPERFAMILY SSF51735 140 301 1.82E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39595 8043a330b5b3500ac1264b736c0555b0 222 Gene3D G3DSA:3.40.50.150 6 220 1.2E-74 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS39595 8043a330b5b3500ac1264b736c0555b0 222 SUPERFAMILY SSF53335 7 221 5.31E-46 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS39595 8043a330b5b3500ac1264b736c0555b0 222 Pfam PF01596 O-methyltransferase 21 220 2.0E-64 T 17-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 SHXM_RS34645 883aa064a7d28859ec6ebe28d6e2d52a 86 SUPERFAMILY SSF57850 2 85 7.3E-25 T 17-03-2017 SHXM_RS34645 883aa064a7d28859ec6ebe28d6e2d52a 86 Gene3D G3DSA:3.30.40.10 2 84 2.2E-22 T 17-03-2017 IPR013083 Zinc finger, RING/FYVE/PHD-type SHXM_RS34645 883aa064a7d28859ec6ebe28d6e2d52a 86 Pfam PF02148 Zn-finger in ubiquitin-hydrolases and other protein 37 83 9.5E-12 T 17-03-2017 IPR001607 Zinc finger, UBP-type GO:0008270 SHXM_RS19770 1d12f1b79ec3ee952357f1182b20b4a8 336 TIGRFAM TIGR03559 F420_Rv3520c: probable F420-dependent oxidoreductase, Rv3520c family 2 319 1.0E-129 T 17-03-2017 IPR019951 F420-dependent oxidoreductase-predicted, Rv3520c SHXM_RS19770 1d12f1b79ec3ee952357f1182b20b4a8 336 Pfam PF00296 Luciferase-like monooxygenase 17 314 6.7E-62 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS19770 1d12f1b79ec3ee952357f1182b20b4a8 336 Gene3D G3DSA:3.20.20.30 1 335 1.6E-63 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS19770 1d12f1b79ec3ee952357f1182b20b4a8 336 SUPERFAMILY SSF51679 1 335 3.24E-57 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS33525 1e38b6af6cfd79d2d6a8a74a4968ca1e 238 Gene3D G3DSA:1.10.530.10 165 231 3.9E-7 T 17-03-2017 SHXM_RS33525 1e38b6af6cfd79d2d6a8a74a4968ca1e 238 Pfam PF01464 Transglycosylase SLT domain 162 226 5.9E-7 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS33525 1e38b6af6cfd79d2d6a8a74a4968ca1e 238 SUPERFAMILY SSF53955 166 232 5.63E-10 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 Pfam PF07687 Peptidase dimerisation domain 202 353 4.1E-7 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 Pfam PF01546 Peptidase family M20/M25/M40 89 449 1.2E-21 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 Gene3D G3DSA:3.30.70.360 215 362 5.2E-33 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 Gene3D G3DSA:3.40.630.10 17 214 7.9E-47 T 17-03-2017 SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 Gene3D G3DSA:3.40.630.10 393 455 7.9E-47 T 17-03-2017 SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 SUPERFAMILY SSF53187 16 204 1.31E-47 T 17-03-2017 SHXM_RS40810 91b99644027d142c63537922e7206d7f 463 SUPERFAMILY SSF53187 368 454 1.31E-47 T 17-03-2017 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Pfam PF16640 Bacterial Ig-like domain (group 3) 256 347 9.4E-13 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Pfam PF16640 Bacterial Ig-like domain (group 3) 356 445 2.2E-19 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SUPERFAMILY SSF81296 2 77 1.82E-8 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SMART SM00429 80 161 0.0019 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SMART SM00429 163 245 0.0028 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SMART SM00429 445 527 0.0052 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SUPERFAMILY SSF81296 79 147 1.52E-9 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Gene3D G3DSA:2.130.10.10 529 566 7.2E-5 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SUPERFAMILY SSF81296 446 527 8.66E-10 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Gene3D G3DSA:2.60.40.10 68 160 1.0E-9 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 SUPERFAMILY SSF81296 163 245 3.31E-15 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 TIGRFAM TIGR02276 beta_rpt_yvtn: 40-residue YVTN family beta-propeller repeat 530 567 1.7E-11 T 17-03-2017 IPR011964 YVTN beta-propeller repeat SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Gene3D G3DSA:2.60.40.10 164 244 6.8E-15 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Gene3D G3DSA:2.60.40.10 3 67 1.1E-9 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Gene3D G3DSA:2.60.40.10 445 526 1.1E-11 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Pfam PF01833 IPT/TIG domain 3 67 1.8E-5 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Pfam PF01833 IPT/TIG domain 81 157 4.0E-7 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Pfam PF01833 IPT/TIG domain 168 244 8.7E-12 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS29005 ab2c9958ba7f915305cbcff011642a28 569 Pfam PF01833 IPT/TIG domain 446 526 8.6E-10 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 SMART SM00448 2 114 5.2E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 Pfam PF00196 Bacterial regulatory proteins, luxR family 151 206 1.5E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 SUPERFAMILY SSF52172 2 131 4.7E-31 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 Gene3D G3DSA:3.40.50.2300 2 152 5.8E-37 T 17-03-2017 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 SUPERFAMILY SSF46894 142 212 1.02E-18 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 166 182 2.0E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 152 166 2.0E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 182 194 2.0E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 Gene3D G3DSA:1.10.10.10 153 211 7.5E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 ProSitePatterns PS00622 LuxR-type HTH domain signature. 166 193 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 Pfam PF00072 Response regulator receiver domain 4 114 2.4E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS25475 b51f71f8605be4188f787632469a8581 222 SMART SM00421 149 206 8.9E-21 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 26 40 2.5E-6 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 40 58 2.5E-6 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 Gene3D G3DSA:1.10.10.10 7 58 1.1E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 Gene3D G3DSA:3.40.50.2300 187 357 5.2E-25 T 17-03-2017 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 SUPERFAMILY SSF53822 74 357 3.77E-28 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 ProSitePatterns PS00894 DeoR-type HTH domain signature. 8 42 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 Pfam PF08220 DeoR-like helix-turn-helix domain 8 61 7.6E-12 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 Pfam PF13377 Periplasmic binding protein-like domain 188 356 1.8E-23 T 17-03-2017 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 Gene3D G3DSA:3.40.50.2300 73 186 2.1E-15 T 17-03-2017 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 SMART SM00420 8 60 2.4E-10 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08130 48f15c4834f649a5e7229038a9d36dea 360 SUPERFAMILY SSF46785 7 61 9.93E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 SUPERFAMILY SSF49303 797 914 1.08E-31 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 Gene3D G3DSA:2.60.120.260 77 226 1.2E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 Gene3D G3DSA:3.20.20.80 354 580 6.1E-24 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 Gene3D G3DSA:3.20.20.80 624 695 6.1E-24 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 SUPERFAMILY SSF49785 80 235 3.54E-36 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 SUPERFAMILY SSF49303 240 355 2.16E-22 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 SUPERFAMILY SSF51445 352 690 9.58E-69 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 Pfam PF00703 Glycosyl hydrolases family 2 241 355 8.4E-16 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 SUPERFAMILY SSF49303 692 795 6.04E-22 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS06860 d395f5fc50199c5846322e22feb0893a 921 Gene3D G3DSA:2.60.40.320 227 353 6.4E-16 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Pfam PF00293 NUDIX domain 346 462 9.2E-12 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Pfam PF13489 Methyltransferase domain 31 153 5.0E-11 T 17-03-2017 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 ProSitePatterns PS00893 Nudix box signature. 379 400 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Pfam PF04266 ASCH domain 222 322 9.4E-5 T 17-03-2017 IPR007374 ASCH domain SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 SUPERFAMILY SSF88697 217 327 2.36E-16 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 PRINTS PR00502 NUDIX hydrolase family signature 374 388 6.9E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 PRINTS PR00502 NUDIX hydrolase family signature 388 403 6.9E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 SUPERFAMILY SSF53335 7 169 2.61E-23 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 SUPERFAMILY SSF55811 333 473 9.61E-19 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Gene3D G3DSA:3.40.50.150 453 476 2.0E-21 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Gene3D G3DSA:3.40.50.150 5 142 2.0E-21 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Gene3D G3DSA:3.90.79.10 343 452 6.2E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS01645 8e1bda73fbc5234ad4ae3152e52d94de 493 Gene3D G3DSA:3.10.480.10 217 324 2.6E-24 T 17-03-2017 SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 SUPERFAMILY SSF53383 15 387 2.64E-121 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 Hamap MF_01107 Acetylornithine/succinyldiaminopimelate aminotransferase [argD]. 11 387 43.14 T 17-03-2017 IPR004636 Acetylornithine/Succinylornithine transaminase family GO:0006525|GO:0008483 SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 TIGRFAM TIGR00707 argD: transaminase, acetylornithine/succinylornithine family 14 386 7.9E-140 T 17-03-2017 IPR004636 Acetylornithine/Succinylornithine transaminase family GO:0006525|GO:0008483 SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 Gene3D G3DSA:3.40.640.10 57 280 2.6E-86 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 Pfam PF00202 Aminotransferase class-III 23 385 1.5E-107 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 214 251 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS12980 a3552023fcd4c90695e919692fe7fa4f 400 Gene3D G3DSA:3.90.1150.10 281 388 2.2E-37 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS50595 a62085c0426ec86f8ec1b01ec17cfbc2 183 SUPERFAMILY SSF50475 23 173 3.53E-46 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS50595 a62085c0426ec86f8ec1b01ec17cfbc2 183 SMART SM00903 32 175 7.7E-57 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS50595 a62085c0426ec86f8ec1b01ec17cfbc2 183 Gene3D G3DSA:2.30.110.10 20 174 2.0E-55 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS50595 a62085c0426ec86f8ec1b01ec17cfbc2 183 Pfam PF01613 Flavin reductase like domain 33 176 3.6E-39 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS08195 d62b6ffa0011f5f4d0305e31542e2a07 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 58 9.0E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08195 d62b6ffa0011f5f4d0305e31542e2a07 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 2.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08195 d62b6ffa0011f5f4d0305e31542e2a07 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 2.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08195 d62b6ffa0011f5f4d0305e31542e2a07 213 SUPERFAMILY SSF46689 2 84 1.33E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08195 d62b6ffa0011f5f4d0305e31542e2a07 213 Gene3D G3DSA:1.10.357.10 2 192 1.6E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS08195 d62b6ffa0011f5f4d0305e31542e2a07 213 SUPERFAMILY SSF48498 79 193 6.68E-26 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 Hamap MF_01685 Ferredoxin--NADP reductase. 18 337 37.674 T 17-03-2017 IPR022890 Ferredoxin--NADP reductase, type 2 GO:0004324|GO:0055114 KEGG: 00195+1.18.1.2|MetaCyc: PWY-101|MetaCyc: PWY-7230 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 SUPERFAMILY SSF51905 19 321 2.47E-36 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 20 305 2.1E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 165 183 4.0E-17 T 17-03-2017 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 21 40 4.0E-17 T 17-03-2017 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 274 296 4.0E-17 T 17-03-2017 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 Gene3D G3DSA:3.50.50.60 162 320 2.6E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 Gene3D G3DSA:3.50.50.60 18 138 5.9E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 20 42 1.8E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 124 132 1.8E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 77 87 1.8E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 161 185 1.8E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS45770 6b640211f8655e9a7ee9e7663ae1583b 339 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 212 228 1.8E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS12075 d7065a6dae561b1b719b5af03317577f 315 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 119 309 6.9E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12075 d7065a6dae561b1b719b5af03317577f 315 SUPERFAMILY SSF161098 94 292 8.24E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12075 d7065a6dae561b1b719b5af03317577f 315 Gene3D G3DSA:1.10.3720.10 92 303 8.0E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 Pfam PF00270 DEAD/DEAH box helicase 33 180 3.7E-10 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 Pfam PF12029 Domain of unknown function (DUF3516) 374 839 3.0E-214 T 17-03-2017 IPR021904 Protein of unknown function DUF3516 SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 SMART SM00487 27 212 5.5E-18 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 Gene3D G3DSA:3.40.50.300 219 377 4.4E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 SMART SM00490 277 363 1.5E-12 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 Gene3D G3DSA:3.40.50.300 18 192 2.2E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 Pfam PF00271 Helicase conserved C-terminal domain 244 363 4.4E-6 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 SUPERFAMILY SSF52540 44 250 9.91E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45160 62e0aa9c1bceb44762d8d4dab792faff 842 SUPERFAMILY SSF52540 283 375 9.91E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 Gene3D G3DSA:3.30.300.30 425 525 2.5E-25 T 17-03-2017 SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 Gene3D G3DSA:3.40.50.980 190 334 1.1E-30 T 17-03-2017 SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 SUPERFAMILY SSF56801 7 529 3.92E-128 T 17-03-2017 SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 Gene3D G3DSA:3.40.50.980 10 189 1.2E-35 T 17-03-2017 SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 Pfam PF00501 AMP-binding enzyme 16 430 4.6E-84 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 Gene3D G3DSA:2.30.38.10 353 421 7.3E-23 T 17-03-2017 SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 ProSitePatterns PS00455 Putative AMP-binding domain signature. 184 195 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS47920 4ddf73de6e0f33974e65432178f08110 539 Pfam PF13193 AMP-binding enzyme C-terminal domain 440 506 1.9E-16 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS30745 621bb8eaca1f0591fd4f5b95ac65f478 139 Pfam PF00571 CBS domain 81 125 3.5E-11 T 17-03-2017 IPR000644 CBS domain SHXM_RS30745 621bb8eaca1f0591fd4f5b95ac65f478 139 Pfam PF00571 CBS domain 5 55 1.5E-10 T 17-03-2017 IPR000644 CBS domain SHXM_RS30745 621bb8eaca1f0591fd4f5b95ac65f478 139 Gene3D G3DSA:3.10.580.10 2 121 2.7E-32 T 17-03-2017 SHXM_RS30745 621bb8eaca1f0591fd4f5b95ac65f478 139 SUPERFAMILY SSF54631 2 132 2.27E-34 T 17-03-2017 SHXM_RS30745 621bb8eaca1f0591fd4f5b95ac65f478 139 SMART SM00116 11 59 2.5E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS30745 621bb8eaca1f0591fd4f5b95ac65f478 139 SMART SM00116 77 125 2.4E-10 T 17-03-2017 IPR000644 CBS domain SHXM_RS21310 6242ecb4f9f8baccae22cde6f365f942 410 Pfam PF04055 Radical SAM superfamily 35 213 1.7E-22 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS21310 6242ecb4f9f8baccae22cde6f365f942 410 SMART SM00729 29 259 5.3E-63 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS21310 6242ecb4f9f8baccae22cde6f365f942 410 TIGRFAM TIGR00539 hemN_rel: putative oxygen-independent coproporphyrinogen III oxidase 32 364 2.2E-70 T 17-03-2017 IPR004559 Coproporphyrinogen III oxidase, oxygen-independent related GO:0004109|GO:0005737|GO:0006779|GO:0055114 SHXM_RS21310 6242ecb4f9f8baccae22cde6f365f942 410 Gene3D G3DSA:3.80.30.20 32 274 2.6E-38 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS21310 6242ecb4f9f8baccae22cde6f365f942 410 SUPERFAMILY SSF102114 21 408 6.28E-108 T 17-03-2017 SHXM_RS28630 95bf5da76bdfa77c79917991684ba581 155 PRINTS PR00502 NUDIX hydrolase family signature 44 58 2.3E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS28630 95bf5da76bdfa77c79917991684ba581 155 PRINTS PR00502 NUDIX hydrolase family signature 58 73 2.3E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS28630 95bf5da76bdfa77c79917991684ba581 155 Gene3D G3DSA:3.90.79.10 8 147 8.0E-36 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS28630 95bf5da76bdfa77c79917991684ba581 155 SUPERFAMILY SSF55811 4 150 2.71E-37 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS28630 95bf5da76bdfa77c79917991684ba581 155 ProSitePatterns PS00893 Nudix box signature. 49 70 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS28630 95bf5da76bdfa77c79917991684ba581 155 Pfam PF00293 NUDIX domain 19 146 1.5E-22 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 SMART SM00487 55 268 5.5E-55 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 Pfam PF00270 DEAD/DEAH box helicase 60 236 3.0E-49 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 Gene3D G3DSA:3.40.50.300 266 417 1.7E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 Gene3D G3DSA:3.40.50.300 35 265 2.6E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 SMART SM00490 304 385 1.2E-31 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 Pfam PF00271 Helicase conserved C-terminal domain 277 385 5.5E-27 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 SUPERFAMILY SSF52540 117 405 4.16E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34190 525b2af19eb80811e17f3f59a6bce9e6 860 ProSitePatterns PS00039 DEAD-box subfamily ATP-dependent helicases signature. 196 204 - T 17-03-2017 IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Gene3D G3DSA:3.40.47.10 172 311 2.2E-70 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Gene3D G3DSA:3.40.47.10 14 139 2.2E-70 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Gene3D G3DSA:3.90.470.20 1312 1406 1.0E-8 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Gene3D G3DSA:3.40.366.10 642 698 6.8E-24 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Gene3D G3DSA:3.40.366.10 755 868 6.8E-24 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Pfam PF14765 Polyketide synthase dehydratase 1000 1278 5.1E-13 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 307 427 1.6E-33 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Pfam PF00698 Acyl transferase domain 630 837 4.0E-14 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 432 507 1.7E-9 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF52151 583 685 1.83E-27 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF52151 757 859 1.83E-27 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 212 228 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF55048 693 754 1.57E-5 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Gene3D G3DSA:3.40.47.10 312 475 2.9E-51 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF53901 451 472 2.83E-74 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF53901 8 135 2.83E-74 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF53901 194 423 2.83E-74 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 13 299 8.2E-63 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SUPERFAMILY SSF56214 1312 1406 5.1E-11 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SMART SM00825 Beta-ketoacyl synthase 14 476 1.9E-102 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04285 6d30ebd7845f8d4eb2dd8a5f0c657792 1555 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 587 864 9.6E-12 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 122 135 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 Gene3D G3DSA:1.10.10.10 260 313 7.0E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 SUPERFAMILY SSF88659 171 246 1.26E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 Gene3D G3DSA:1.10.10.10 166 221 2.2E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 Pfam PF04545 Sigma-70, region 4 265 313 2.5E-17 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 SUPERFAMILY SSF88946 60 167 3.92E-31 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 93 314 2.5E-92 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 PRINTS PR00046 Major sigma-70 factor signature 268 280 2.2E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 PRINTS PR00046 Major sigma-70 factor signature 122 135 2.2E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 PRINTS PR00046 Major sigma-70 factor signature 285 300 2.2E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 PRINTS PR00046 Major sigma-70 factor signature 300 311 2.2E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 Pfam PF04539 Sigma-70 region 3 178 244 1.0E-14 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 SUPERFAMILY SSF88659 234 315 2.62E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 95 314 5.2E-32 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 Gene3D G3DSA:1.10.601.10 81 165 6.0E-24 T 17-03-2017 SHXM_RS24370 3b73c5579a736eca8353dc4551b9b85e 319 Pfam PF04542 Sigma-70 region 2 98 167 1.5E-16 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Gene3D G3DSA:3.40.50.720 14 100 3.3E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Gene3D G3DSA:3.90.190.20 326 470 4.9E-49 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Pfam PF02875 Mur ligase family, glutamate ligase domain 324 410 3.4E-19 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 SUPERFAMILY SSF51984 13 100 7.85E-24 T 17-03-2017 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 TIGRFAM TIGR01082 murC: UDP-N-acetylmuramate--L-alanine ligase 15 465 1.1E-137 T 17-03-2017 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Hamap MF_00046 UDP-N-acetylmuramate--L-alanine ligase [murC]. 11 471 38.069 T 17-03-2017 IPR005758 UDP-N-acetylmuramate--L-alanine ligase GO:0008763|GO:0009252 KEGG: 00471+6.3.2.8|KEGG: 00550+6.3.2.8|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Gene3D G3DSA:3.40.1190.10 101 325 1.4E-71 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 SUPERFAMILY SSF53623 98 321 5.8E-55 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Pfam PF01225 Mur ligase family, catalytic domain 15 111 2.2E-27 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 SUPERFAMILY SSF53244 323 467 3.89E-42 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS38490 b6213af868f0ad86fe2b4ef3f1d06f3b 474 Pfam PF08245 Mur ligase middle domain 117 303 1.6E-22 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 31 91 4.0E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 SMART SM00829 13 316 4.4E-14 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 Gene3D G3DSA:3.40.50.720 155 241 9.7E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 SUPERFAMILY SSF51735 120 293 2.75E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 Gene3D G3DSA:3.90.180.10 2 154 2.2E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 Pfam PF13602 Zinc-binding dehydrogenase 190 316 2.8E-21 T 17-03-2017 SHXM_RS04170 99bf9b05d0c12f61b79e0f65b09fedef 319 SUPERFAMILY SSF50129 3 152 5.33E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 Gene3D G3DSA:3.40.50.720 125 176 2.6E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 Gene3D G3DSA:3.40.50.720 6 78 2.6E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 Gene3D G3DSA:3.40.50.720 267 316 2.6E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 SUPERFAMILY SSF54373 184 273 3.01E-15 T 17-03-2017 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 Gene3D G3DSA:3.30.9.10 83 114 3.2E-36 T 17-03-2017 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 Gene3D G3DSA:3.30.9.10 177 266 3.2E-36 T 17-03-2017 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 Pfam PF01266 FAD dependent oxidoreductase 6 310 6.1E-34 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 PIRSF PIRSF000189 3 316 1.7E-76 T 17-03-2017 IPR023209 D-amino-acid oxidase GO:0003884|GO:0046416|GO:0071949 Reactome: R-HSA-389661 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 SUPERFAMILY SSF51971 259 316 1.47E-28 T 17-03-2017 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 SUPERFAMILY SSF51971 4 197 1.47E-28 T 17-03-2017 SHXM_RS35100 6cb22d9535c426abf098a6e912f13c04 317 ProSitePatterns PS00677 D-amino acid oxidases signature. 289 307 - T 17-03-2017 IPR006181 D-amino acid oxidase, conserved site GO:0003884|GO:0055114 Reactome: R-HSA-389661 SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 Pfam PF12802 MarR family 35 91 5.1E-13 T 17-03-2017 SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 Gene3D G3DSA:1.10.10.10 5 138 1.5E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 PRINTS PR00598 Bacterial regulatory protein MarR family signature 69 84 1.8E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 PRINTS PR00598 Bacterial regulatory protein MarR family signature 52 68 1.8E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 PRINTS PR00598 Bacterial regulatory protein MarR family signature 88 104 1.8E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 PRINTS PR00598 Bacterial regulatory protein MarR family signature 117 137 1.8E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 SUPERFAMILY SSF46785 6 139 1.07E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20455 df057e40697628f8bb19ad85c1305e04 142 SMART SM00347 29 127 3.9E-16 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32475 234960f93b7d87acbdb7e67d75c56abe 150 Gene3D G3DSA:3.40.50.270 9 133 6.2E-40 T 17-03-2017 SHXM_RS32475 234960f93b7d87acbdb7e67d75c56abe 150 SMART SM00226 10 135 3.9E-44 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS32475 234960f93b7d87acbdb7e67d75c56abe 150 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 12 132 1.7E-22 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS32475 234960f93b7d87acbdb7e67d75c56abe 150 SUPERFAMILY SSF52788 9 133 2.75E-36 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS26015 473ed9b000c453ce8c712601ad33419b 166 Gene3D G3DSA:3.30.1330.50 10 165 5.4E-51 T 17-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 SHXM_RS26015 473ed9b000c453ce8c712601ad33419b 166 TIGRFAM TIGR00151 ispF: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 11 164 6.0E-41 T 17-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 SHXM_RS26015 473ed9b000c453ce8c712601ad33419b 166 Pfam PF02542 YgbB family 11 163 2.4E-43 T 17-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 SHXM_RS26015 473ed9b000c453ce8c712601ad33419b 166 SUPERFAMILY SSF69765 10 164 7.72E-47 T 17-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 SHXM_RS26015 473ed9b000c453ce8c712601ad33419b 166 Hamap MF_00107 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [ispF]. 9 165 29.651 T 17-03-2017 IPR003526 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase GO:0008685|GO:0016114 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 SHXM_RS26015 473ed9b000c453ce8c712601ad33419b 166 ProSitePatterns PS01350 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase signature. 47 62 - T 17-03-2017 IPR020555 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site GO:0008685 KEGG: 00900+4.6.1.12|MetaCyc: PWY-7560 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:3.40.50.720 1477 1675 5.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:1.10.1200.10 1759 1835 9.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 575 875 3.8E-114 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF08659 KR domain 1478 1657 2.0E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF47336 1755 1840 1.7E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:3.40.366.10 766 877 1.5E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:3.40.366.10 569 694 1.5E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF52151 767 869 6.54E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF52151 573 700 6.54E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 4.6E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 3.4E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF14765 Polyketide synthase dehydratase 944 1235 8.1E-53 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1789 1804 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF00698 Acyl transferase domain 574 894 6.8E-82 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF51735 1246 1449 1.38E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF00550 Phosphopantetheine attachment site 1765 1830 3.0E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SMART SM00826 944 1121 7.8E-76 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF53901 31 406 1.85E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SMART SM00823 Phosphopantetheine attachment site 1762 1834 2.1E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:3.30.70.250 700 765 8.6E-9 T 17-03-2017 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SMART SM01294 1764 1830 6.5E-4 T 17-03-2017 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 535 5.4E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF101173 4 34 3.27E-6 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:3.40.47.10 30 296 6.7E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1478 1658 2.7E-55 T 17-03-2017 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Gene3D G3DSA:3.40.47.10 297 463 4.6E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF51735 1476 1714 4.2E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 Pfam PF08990 Erythronolide synthase docking 2 27 3.1E-9 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SMART SM00825 Beta-ketoacyl synthase 36 462 1.4E-224 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06395 800112ce887f7a41d8e5a5b9f1fde258 1928 SUPERFAMILY SSF55048 698 766 1.96E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS28215 7f08b8b2a3ea06f1574781dac6dab0d7 85 Pfam PF06781 Uncharacterised protein family (UPF0233) 2 85 1.5E-28 T 17-03-2017 IPR009619 Cell division protein CrgA SHXM_RS28215 7f08b8b2a3ea06f1574781dac6dab0d7 85 Hamap MF_00631 Cell division protein CrgA [crgA]. 1 85 22.766 T 17-03-2017 IPR009619 Cell division protein CrgA SHXM_RS43675 21e9fc709609ea78b455a87cad7a500c 412 SUPERFAMILY SSF52266 75 269 2.6E-32 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS43675 21e9fc709609ea78b455a87cad7a500c 412 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 81 259 6.4E-22 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS43675 21e9fc709609ea78b455a87cad7a500c 412 Gene3D G3DSA:3.40.50.1110 75 269 9.8E-29 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS35045 548b738eea1cb213af9f82aac73d157c 275 SMART SM00155 212 239 2.8E-4 T 17-03-2017 IPR001736 Phospholipase D/Transphosphatidylase GO:0003824 Reactome: R-HSA-1483148 SHXM_RS35045 548b738eea1cb213af9f82aac73d157c 275 SUPERFAMILY SSF56024 124 262 1.04E-12 T 17-03-2017 SHXM_RS35045 548b738eea1cb213af9f82aac73d157c 275 Pfam PF13091 PLD-like domain 133 258 3.1E-9 T 17-03-2017 IPR025202 Phospholipase D-like domain Reactome: R-HSA-1483148 SHXM_RS35045 548b738eea1cb213af9f82aac73d157c 275 Gene3D G3DSA:3.30.870.10 126 260 6.7E-10 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:1.10.1200.10 2037 2109 1.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:1.10.1200.10 3393 3469 4.9E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00826 929 1102 1.2E-69 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00826 3049 3228 8.8E-66 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF14765 Polyketide synthase dehydratase 3049 3353 3.3E-50 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF14765 Polyketide synthase dehydratase 929 1225 2.6E-49 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF47336 2036 2150 1.57E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.90.180.10 1449 1522 3.3E-8 T 17-03-2017 IPR011032 GroES-like SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF55048 690 754 5.23E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.50.720 1761 1942 1.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.50.720 1990 1997 1.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00824 Thioesterase 3593 3808 3.6E-62 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF53901 32 399 5.92E-98 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1460 1520 1.7E-4 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF53901 2536 2552 7.74E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF53901 2132 2504 7.74E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2136 2383 2.6E-83 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 1.3E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00550 Phosphopantetheine attachment site 2041 2106 4.8E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00550 Phosphopantetheine attachment site 3398 3463 1.5E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1761 1938 1.2E-53 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2066 2081 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00698 Acyl transferase domain 2674 3002 1.9E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00698 Acyl transferase domain 564 879 3.8E-81 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF55048 2800 2865 2.22E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00825 Beta-ketoacyl synthase 2138 2561 6.5E-207 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00825 Beta-ketoacyl synthase 36 462 9.4E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00829 1441 1752 1.5E-167 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.47.10 36 296 2.7E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.47.10 2138 2395 5.0E-86 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2296 2312 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2511 2626 3.5E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 527 7.1E-17 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2676 2984 7.2E-123 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 566 862 1.1E-118 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.30.70.250 690 751 8.3E-6 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.30.70.250 2801 2864 2.4E-5 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF52151 2674 2801 1.23E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF52151 2866 2959 1.23E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF00975 Thioesterase domain 3591 3805 1.1E-18 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM01294 2040 2107 3.1E-5 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM01294 3396 3463 3.2E-6 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF13602 Zinc-binding dehydrogenase 1623 1752 2.1E-18 T 17-03-2017 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF53474 3568 3809 1.4E-30 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF53474 3438 3463 1.4E-30 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.366.10 2865 2997 5.1E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.366.10 754 876 1.0E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.366.10 563 686 1.0E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.366.10 2668 2796 5.1E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF52151 564 691 1.18E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF52151 755 848 1.18E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF51735 1232 1417 9.05E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF51735 1760 1997 1.32E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF08990 Erythronolide synthase docking 6 26 1.4E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF47336 3388 3486 1.44E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00823 Phosphopantetheine attachment site 3395 3467 3.7E-18 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SMART SM00823 Phosphopantetheine attachment site 2039 2111 3.6E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF08659 KR domain 1761 1936 1.5E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF51735 1547 1722 3.13E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.47.10 2396 2561 2.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.47.10 297 463 9.4E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.50.1820 3535 3809 9.7E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Gene3D G3DSA:3.40.50.720 1537 1725 3.4E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 2.8E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2391 2508 3.1E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 SUPERFAMILY SSF50129 1456 1574 2.04E-23 T 17-03-2017 IPR011032 GroES-like SHXM_RS38775 50bf888beb25a3acc46068043da00cf0 3813 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3422 3437 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS40460 e23d83de1efa31beab70c68e1b33c714 406 Gene3D G3DSA:1.20.1250.20 20 202 1.2E-17 T 17-03-2017 SHXM_RS40460 e23d83de1efa31beab70c68e1b33c714 406 Gene3D G3DSA:1.20.1250.20 218 391 6.1E-14 T 17-03-2017 SHXM_RS40460 e23d83de1efa31beab70c68e1b33c714 406 Pfam PF07690 Major Facilitator Superfamily 24 325 2.4E-19 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS40460 e23d83de1efa31beab70c68e1b33c714 406 SUPERFAMILY SSF103473 17 392 4.32E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 11 30 4.3E-7 T 17-03-2017 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 394 416 4.3E-7 T 17-03-2017 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 Pfam PF00890 FAD binding domain 10 430 1.3E-93 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 Gene3D G3DSA:1.20.58.100 493 588 6.8E-31 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 Gene3D G3DSA:3.50.50.60 385 451 9.3E-105 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 Gene3D G3DSA:3.50.50.60 2 249 9.3E-105 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 SUPERFAMILY SSF46977 493 648 3.4E-37 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 Gene3D G3DSA:3.90.700.10 250 383 7.1E-36 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 SUPERFAMILY SSF56425 243 389 1.94E-33 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 Pfam PF02910 Fumarate reductase flavoprotein C-term 500 597 1.6E-21 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 PIRSF PIRSF000171 1 612 1.3E-35 T 17-03-2017 IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 SUPERFAMILY SSF51905 393 453 4.13E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33820 6f3d53a542e58177d1d6633be417a9d1 651 SUPERFAMILY SSF51905 4 270 4.13E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 SUPERFAMILY SSF51338 365 388 3.68E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 SUPERFAMILY SSF51338 4 54 3.68E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 Pfam PF01979 Amidohydrolase family 50 396 1.3E-20 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 Gene3D G3DSA:2.30.40.10 350 399 5.2E-4 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 Gene3D G3DSA:3.20.20.140 70 349 9.1E-61 T 17-03-2017 SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 SUPERFAMILY SSF51556 54 364 1.51E-47 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS39950 2418007dbdde13f9d8c496a2ea6dfe55 404 Gene3D G3DSA:2.30.40.10 4 69 3.3E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14885 2852890a45b767332682c687a451af9f 492 Pfam PF07690 Major Facilitator Superfamily 44 440 3.6E-41 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS14885 2852890a45b767332682c687a451af9f 492 Gene3D G3DSA:1.20.1250.20 42 221 1.7E-23 T 17-03-2017 SHXM_RS14885 2852890a45b767332682c687a451af9f 492 SUPERFAMILY SSF103473 283 480 4.45E-51 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14885 2852890a45b767332682c687a451af9f 492 SUPERFAMILY SSF103473 29 226 4.45E-51 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14885 2852890a45b767332682c687a451af9f 492 Gene3D G3DSA:1.20.1250.20 297 476 1.1E-12 T 17-03-2017 SHXM_RS41910 a5fdcca8b4d0781e6aa72c9a7eb558b8 478 Gene3D G3DSA:3.40.605.10 13 231 5.3E-36 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS41910 a5fdcca8b4d0781e6aa72c9a7eb558b8 478 Gene3D G3DSA:3.40.309.10 232 414 2.6E-47 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS41910 a5fdcca8b4d0781e6aa72c9a7eb558b8 478 Pfam PF00171 Aldehyde dehydrogenase family 11 426 9.3E-42 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS41910 a5fdcca8b4d0781e6aa72c9a7eb558b8 478 SUPERFAMILY SSF53720 10 472 2.75E-85 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.366.10 534 661 1.4E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.366.10 730 858 1.4E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 ProSitePatterns PS00012 Phosphopantetheine attachment site. 962 977 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1288 1405 3.1E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 257 374 4.3E-38 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00825 Beta-ketoacyl synthase 1032 1458 2.0E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00825 Beta-ketoacyl synthase 1 427 1.0E-193 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1408 1526 2.4E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 377 500 6.3E-18 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF47336 935 1045 5.23E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF14765 Polyketide synthase dehydratase 1939 2229 3.2E-50 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00826 1939 2107 2.8E-74 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1567 1870 4.1E-117 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 538 845 6.6E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.30.70.250 665 729 2.6E-11 T 17-03-2017 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.30.70.250 1690 1757 1.3E-8 T 17-03-2017 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:1.10.1200.10 935 1006 1.7E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:1.10.1200.10 2277 2350 2.7E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2305 2320 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF00550 Phosphopantetheine attachment site 936 1003 4.3E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF00550 Phosphopantetheine attachment site 2281 2346 3.8E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM01294 2279 2346 6.6E-4 T 17-03-2017 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM01294 936 1003 4.7E-4 T 17-03-2017 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00823 Phosphopantetheine attachment site 935 1007 3.9E-26 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SMART SM00823 Phosphopantetheine attachment site 2278 2350 2.0E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF55048 665 729 7.32E-15 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.47.10 1 261 6.5E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.47.10 1032 1292 1.6E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1193 1209 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 248 1.8E-78 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1030 1280 3.3E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.366.10 1563 1686 1.1E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.366.10 1758 1874 1.1E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.47.10 1293 1459 3.7E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Gene3D G3DSA:3.40.47.10 264 427 2.8E-57 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF00698 Acyl transferase domain 1566 1889 5.4E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 Pfam PF00698 Acyl transferase domain 537 864 1.2E-59 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF52151 1565 1692 1.26E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF52151 1759 1857 1.26E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF47336 2273 2359 5.89E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF53901 1028 1396 2.28E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF55048 1690 1758 1.57E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF52151 730 826 9.94E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF52151 535 666 9.94E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06460 4e2c98076c9a7098d860d4e2b37efe42 2402 SUPERFAMILY SSF53901 1 370 6.89E-85 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 SUPERFAMILY SSF53383 487 900 3.46E-100 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 SUPERFAMILY SSF53383 942 965 3.46E-100 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 SUPERFAMILY SSF53383 20 447 6.9E-100 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 Hamap MF_00711 Glycine dehydrogenase (decarboxylating) [gcvP]. 11 969 25.695 T 17-03-2017 IPR003437 Glycine dehydrogenase (decarboxylating) GO:0004375|GO:0006544|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 Pfam PF02347 Glycine cleavage system P-protein 462 746 6.5E-13 T 17-03-2017 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 Pfam PF02347 Glycine cleavage system P-protein 19 448 3.6E-177 T 17-03-2017 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 TIGRFAM TIGR00461 gcvP: glycine dehydrogenase 20 963 0.0 T 17-03-2017 IPR003437 Glycine dehydrogenase (decarboxylating) GO:0004375|GO:0006544|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 Gene3D G3DSA:3.40.640.10 515 751 2.1E-39 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS43970 9165c0ab188bc60946d7d194aba53935 971 Gene3D G3DSA:3.40.640.10 93 310 4.7E-15 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 SMART SM00116 13 61 1.3E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 SMART SM00116 95 143 2.7E-12 T 17-03-2017 IPR000644 CBS domain SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 Pfam PF00571 CBS domain 89 142 3.4E-15 T 17-03-2017 IPR000644 CBS domain SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 Pfam PF00571 CBS domain 6 59 2.9E-14 T 17-03-2017 IPR000644 CBS domain SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 PIRSF PIRSF036990 4 223 8.6E-61 T 17-03-2017 IPR017080 Uncharacterised conserved protein UCP036990, CBS, BON SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 Gene3D G3DSA:3.10.580.10 5 143 4.4E-33 T 17-03-2017 SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 Pfam PF04972 BON domain 146 212 1.4E-9 T 17-03-2017 IPR007055 BON domain SHXM_RS43500 fe379aa374663b07394f3b0d8c7c8c2b 224 SUPERFAMILY SSF54631 1 144 1.71E-34 T 17-03-2017 SHXM_RS11660 2fa9afa522b22f5ef6e953fd0b9157de 254 Gene3D G3DSA:3.40.630.30 117 247 8.9E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS11660 2fa9afa522b22f5ef6e953fd0b9157de 254 SUPERFAMILY SSF55729 72 248 2.23E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS11660 2fa9afa522b22f5ef6e953fd0b9157de 254 Pfam PF13527 Acetyltransferase (GNAT) domain 187 242 1.6E-6 T 17-03-2017 SHXM_RS13970 06bd942e9454ba8002ab0ea3e8b043d9 459 Pfam PF02347 Glycine cleavage system P-protein 11 453 3.5E-63 T 17-03-2017 IPR020580 Glycine cleavage system P-protein, N-terminal GO:0004375|GO:0006546|GO:0055114 KEGG: 00260+1.4.4.2|Reactome: R-HSA-6783984 SHXM_RS13970 06bd942e9454ba8002ab0ea3e8b043d9 459 Gene3D G3DSA:3.90.1150.10 346 457 9.8E-5 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS13970 06bd942e9454ba8002ab0ea3e8b043d9 459 SUPERFAMILY SSF53383 17 457 2.98E-71 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS13970 06bd942e9454ba8002ab0ea3e8b043d9 459 Gene3D G3DSA:3.40.640.10 69 309 3.8E-13 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS13405 151213df4f91db10281a9f9d4616e646 277 ProSitePatterns PS00211 ABC transporters family signature. 181 195 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS13405 151213df4f91db10281a9f9d4616e646 277 Pfam PF00005 ABC transporter 75 208 2.2E-14 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS13405 151213df4f91db10281a9f9d4616e646 277 Gene3D G3DSA:3.40.50.300 69 272 3.6E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13405 151213df4f91db10281a9f9d4616e646 277 SUPERFAMILY SSF52540 69 271 1.57E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13405 151213df4f91db10281a9f9d4616e646 277 SMART SM00382 83 257 1.6E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Gene3D G3DSA:3.50.50.60 19 120 2.4E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 TIGRFAM TIGR02374 nitri_red_nirB: nitrite reductase [NAD(P)H], large subunit 20 824 0.0 T 17-03-2017 IPR012744 Nitrite reductase [NAD(P)H] large subunit, NirB GO:0008942|GO:0042128|GO:0050660|GO:0050661|GO:0055114 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 162 187 7.0E-10 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 291 298 7.0E-10 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 120 129 7.0E-10 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 250 264 7.0E-10 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 SUPERFAMILY SSF51905 161 327 5.19E-26 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 656 792 1.7E-18 T 17-03-2017 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Gene3D G3DSA:3.30.413.10 656 793 5.6E-34 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 584 645 1.7E-9 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Gene3D G3DSA:3.50.50.60 121 325 3.0E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Pfam PF04324 BFD-like [2Fe-2S] binding domain 436 484 2.9E-13 T 17-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 ProSitePatterns PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 703 719 - T 17-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 SUPERFAMILY SSF56014 657 831 4.71E-50 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 SUPERFAMILY SSF55124 534 665 8.34E-22 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 SUPERFAMILY SSF51905 19 202 1.21E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 276 298 8.7E-16 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 249 265 8.7E-16 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 117 135 8.7E-16 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 162 180 8.7E-16 T 17-03-2017 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00397 Sirohaem Fe-binding site signature 660 678 1.4E-5 T 17-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PRINTS PR00397 Sirohaem Fe-binding site signature 703 721 1.4E-5 T 17-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 20 306 3.3E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20720 f15432480f18a0d5770d088e63c41719 877 PIRSF PIRSF037149 13 859 0.0 T 17-03-2017 IPR017121 Nitrite reductase [NAD(P)H], large subunit GO:0042128 SHXM_RS49635 b825277d5f317e22cf52b77ba3db6958 275 SUPERFAMILY SSF51905 31 187 6.47E-14 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49635 b825277d5f317e22cf52b77ba3db6958 275 Gene3D G3DSA:3.50.50.60 144 182 3.3E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49635 b825277d5f317e22cf52b77ba3db6958 275 Gene3D G3DSA:3.50.50.60 32 88 3.3E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49635 b825277d5f317e22cf52b77ba3db6958 275 Pfam PF01266 FAD dependent oxidoreductase 29 182 4.5E-18 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 SMART SM00829 10 344 2.9E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 128 1.5E-30 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 Pfam PF00107 Zinc-binding dehydrogenase 176 306 2.2E-26 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 SUPERFAMILY SSF51735 138 314 2.32E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 Gene3D G3DSA:3.90.180.10 1 169 6.6E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 SUPERFAMILY SSF50129 1 170 2.59E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS07590 b74c99074d0c1fa8281b444d484b136e 354 Gene3D G3DSA:3.40.50.720 170 291 1.4E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 Pfam PF01411 tRNA synthetases class II (A) 5 563 7.1E-197 T 17-03-2017 IPR018164 Alanyl-tRNA synthetase, class IIc, N-terminal GO:0000166|GO:0004813|GO:0005524|GO:0006419 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 SUPERFAMILY SSF55681 2 248 1.38E-90 T 17-03-2017 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 662 705 1.4E-17 T 17-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 SUPERFAMILY SSF55186 561 720 4.71E-42 T 17-03-2017 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain GO:0000166 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 PRINTS PR00980 Alanyl-tRNA synthetase signature 69 80 1.4E-28 T 17-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 PRINTS PR00980 Alanyl-tRNA synthetase signature 303 316 1.4E-28 T 17-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 PRINTS PR00980 Alanyl-tRNA synthetase signature 229 242 1.4E-28 T 17-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 PRINTS PR00980 Alanyl-tRNA synthetase signature 196 207 1.4E-28 T 17-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 PRINTS PR00980 Alanyl-tRNA synthetase signature 279 295 1.4E-28 T 17-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 SUPERFAMILY SSF50447 462 560 5.3E-17 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 Hamap MF_00036_B Alanine--tRNA ligase [alaS]. 1 890 168.464 T 17-03-2017 IPR023033 Alanine-tRNA ligase, eukaryota/bacteria GO:0004813 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 SUPERFAMILY SSF101353 249 446 5.62E-60 T 17-03-2017 IPR018162 Alanine-tRNA ligase, class IIc, anti-codon-binding domain GO:0000166|GO:0004813|GO:0005524|GO:0005737|GO:0006419 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 SMART SM00863 662 705 6.5E-21 T 17-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 TIGRFAM TIGR00344 alaS: alanine--tRNA ligase 5 868 4.4E-258 T 17-03-2017 IPR002318 Alanine-tRNA ligase, class IIc GO:0000166|GO:0005737 KEGG: 00970+6.1.1.7 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 Pfam PF02272 DHHA1 domain 813 882 1.2E-11 T 17-03-2017 IPR003156 DHHA1 domain GO:0003676 KEGG: 00970+6.1.1.7|Reactome: R-HSA-379716 SHXM_RS12440 c1ab02fa17d80e628e8bda307e0fdffe 890 Gene3D G3DSA:3.30.930.10 1 244 1.8E-96 T 17-03-2017 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 30 96 5.0E-14 T 17-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 TIGRFAM TIGR00962 atpA: ATP synthase F1, alpha subunit 6 512 3.2E-237 T 17-03-2017 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 153 376 8.3E-67 T 17-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Gene3D G3DSA:1.20.150.20 385 512 3.9E-50 T 17-03-2017 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Hamap MF_01346 ATP synthase subunit alpha [atpA]. 4 513 48.087 T 17-03-2017 IPR005294 ATPase, F1 complex, alpha subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 SUPERFAMILY SSF50615 27 98 2.12E-22 T 17-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Gene3D G3DSA:2.40.30.20 5 97 4.9E-29 T 17-03-2017 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Gene3D G3DSA:3.40.50.300 99 383 4.9E-107 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 Pfam PF00306 ATP synthase alpha/beta chain, C terminal domain 383 508 1.3E-44 T 17-03-2017 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 SUPERFAMILY SSF47917 385 512 1.94E-44 T 17-03-2017 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 SUPERFAMILY SSF52540 100 382 1.44E-92 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35250 9be0ee138908eb2cea3945434712d167 523 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 367 376 - T 17-03-2017 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 26 270 5.9E-65 T 17-03-2017 SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 SUPERFAMILY SSF51735 16 271 3.01E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 164 192 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 167 1.1E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 233 253 1.1E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 96 107 1.1E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 198 215 1.1E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 21 38 1.1E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 196 1.1E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 177 196 2.7E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 96 107 2.7E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 165 2.7E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06830 9968c6496bf57502b5fcaebc2c8ba5f5 279 Gene3D G3DSA:3.40.50.720 17 271 7.1E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47315 a870922551c3259140adde48a0e50afc 224 SUPERFAMILY SSF53474 65 207 3.73E-16 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47315 a870922551c3259140adde48a0e50afc 224 SMART SM00824 Thioesterase 62 201 3.6E-7 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS47315 a870922551c3259140adde48a0e50afc 224 Gene3D G3DSA:3.40.50.1820 38 177 2.4E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47315 a870922551c3259140adde48a0e50afc 224 Pfam PF00975 Thioesterase domain 79 159 5.0E-10 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS18995 e8528217cf1e1c08bff8fc748a0fdfb9 376 Hamap MF_00230 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [cobT]. 12 351 31.643 T 17-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS18995 e8528217cf1e1c08bff8fc748a0fdfb9 376 SUPERFAMILY SSF52733 4 344 8.37E-91 T 17-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS18995 e8528217cf1e1c08bff8fc748a0fdfb9 376 TIGRFAM TIGR03160 cobT_DBIPRT: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 14 343 1.0E-101 T 17-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS18995 e8528217cf1e1c08bff8fc748a0fdfb9 376 Gene3D G3DSA:1.10.1610.10 3 69 1.6E-18 T 17-03-2017 IPR023195 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS18995 e8528217cf1e1c08bff8fc748a0fdfb9 376 Pfam PF02277 Phosphoribosyltransferase 10 343 7.7E-104 T 17-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS18995 e8528217cf1e1c08bff8fc748a0fdfb9 376 Gene3D G3DSA:3.40.50.10210 70 332 1.2E-88 T 17-03-2017 SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 SUPERFAMILY SSF48008 78 215 6.54E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 Gene3D G3DSA:1.10.10.10 5 73 7.7E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 SMART SM00345 15 72 1.8E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 71 2.8E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 33 47 6.7E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 47 63 6.7E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 SMART SM00895 82 206 5.8E-17 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 Pfam PF07729 FCD domain 82 204 1.1E-21 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 Gene3D G3DSA:1.20.120.530 75 217 3.9E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06810 c109cd99b1f9acf9e1edd3e11a12a0ae 225 SUPERFAMILY SSF46785 7 76 9.11E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41795 3ddb57b3a67b4ddfc26e4348fa8eeee4 301 SMART SM00849 64 275 3.4E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41795 3ddb57b3a67b4ddfc26e4348fa8eeee4 301 SUPERFAMILY SSF56281 38 294 1.97E-36 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41795 3ddb57b3a67b4ddfc26e4348fa8eeee4 301 Pfam PF00753 Metallo-beta-lactamase superfamily 65 271 1.2E-22 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41795 3ddb57b3a67b4ddfc26e4348fa8eeee4 301 Gene3D G3DSA:3.60.15.10 12 293 6.5E-48 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01390 3e8a2b80ef13dbea0430f38b7f1839dc 135 SUPERFAMILY SSF54593 5 131 1.38E-24 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS01390 3e8a2b80ef13dbea0430f38b7f1839dc 135 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 8 125 3.1E-5 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS01390 3e8a2b80ef13dbea0430f38b7f1839dc 135 Gene3D G3DSA:3.10.180.10 4 133 7.7E-30 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS00835 fe7dbd36c63c7af4fcc39a4903ce622f 464 Pfam PF03611 PTS system sugar-specific permease component 11 406 5.6E-138 T 17-03-2017 IPR004703 Phosphotransferase system, sugar-specific permease component GO:0009401|GO:0016021 SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 Gene3D G3DSA:3.30.70.250 115 173 1.8E-6 T 17-03-2017 SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 Pfam PF00698 Acyl transferase domain 1 292 2.2E-61 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 SUPERFAMILY SSF52151 182 281 7.06E-55 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 SUPERFAMILY SSF52151 1 116 7.06E-55 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 SUPERFAMILY SSF55048 115 178 6.93E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1 290 6.0E-94 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 Gene3D G3DSA:3.40.366.10 1 110 7.4E-60 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS16690 884ea88cdfea22cf4320f7b4263b6a76 302 Gene3D G3DSA:3.40.366.10 180 291 7.4E-60 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS12965 d9461cb6f74b3ff66ccdc85374ab56f4 264 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 67 257 3.4E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12965 d9461cb6f74b3ff66ccdc85374ab56f4 264 SUPERFAMILY SSF161098 2 258 3.14E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12965 d9461cb6f74b3ff66ccdc85374ab56f4 264 Gene3D G3DSA:1.10.3720.10 2 260 1.5E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 Gene3D G3DSA:3.40.50.720 8 256 1.5E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 220 240 3.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 3.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 3.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 153 172 3.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 191 3.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 3.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 140 168 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 SUPERFAMILY SSF51735 11 256 1.02E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 21 255 7.0E-43 T 17-03-2017 SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 153 172 1.8E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 1.8E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45575 1ec65546b9101dcb66fa0bfd303e1ef9 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 1.8E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 Gene3D G3DSA:3.40.50.720 116 288 3.2E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 Gene3D G3DSA:3.40.50.720 30 115 1.4E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 110 286 7.2E-43 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 SUPERFAMILY SSF52283 29 129 1.97E-13 T 17-03-2017 SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 SUPERFAMILY SSF51735 100 287 1.69E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 197 219 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS08110 e9f30185b555ce63531679c8d3b087de 326 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 32 317 7.7E-9 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 Gene3D G3DSA:3.40.50.980 178 345 1.4E-19 T 17-03-2017 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 Gene3D G3DSA:3.40.50.980 4 177 2.8E-37 T 17-03-2017 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 Pfam PF13193 AMP-binding enzyme C-terminal domain 445 521 5.9E-19 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 SUPERFAMILY SSF56801 4 533 1.57E-115 T 17-03-2017 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 Gene3D G3DSA:2.30.38.10 357 429 5.0E-12 T 17-03-2017 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 Gene3D G3DSA:3.30.300.30 433 530 2.5E-29 T 17-03-2017 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 Pfam PF00501 AMP-binding enzyme 10 435 1.2E-65 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS43590 d76a4c686e4f985f3c61d25bb24ef200 542 ProSitePatterns PS00455 Putative AMP-binding domain signature. 172 183 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 SUPERFAMILY SSF56059 2 343 1.77E-95 T 17-03-2017 SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 19 316 6.8E-92 T 17-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 Pfam PF00391 PEP-utilising enzyme, mobile domain 791 862 7.7E-20 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 Gene3D G3DSA:3.50.30.10 766 864 8.4E-25 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 Gene3D G3DSA:3.30.470.20 187 335 7.2E-45 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 Gene3D G3DSA:3.30.1490.20 3 186 5.2E-62 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS41430 905487f04200147d0b9c5e3f80901f01 871 SUPERFAMILY SSF52009 766 865 1.83E-25 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS39625 1483908710d19c2f3c5d6838dcf2268f 277 SUPERFAMILY SSF54001 22 273 2.45E-60 T 17-03-2017 SHXM_RS39625 1483908710d19c2f3c5d6838dcf2268f 277 Gene3D G3DSA:3.30.2140.10 26 183 3.2E-24 T 17-03-2017 SHXM_RS39625 1483908710d19c2f3c5d6838dcf2268f 277 Pfam PF00797 N-acetyltransferase 41 266 1.0E-34 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS39625 1483908710d19c2f3c5d6838dcf2268f 277 PRINTS PR01543 Arylamine N-acetyltransferase signature 119 144 1.4E-6 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS39625 1483908710d19c2f3c5d6838dcf2268f 277 PRINTS PR01543 Arylamine N-acetyltransferase signature 87 109 1.4E-6 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS39625 1483908710d19c2f3c5d6838dcf2268f 277 PRINTS PR01543 Arylamine N-acetyltransferase signature 41 64 1.4E-6 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS16570 3b065a78f53fd80279f71571c3f2bcc0 285 Gene3D G3DSA:3.20.20.370 57 212 7.6E-30 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS16570 3b065a78f53fd80279f71571c3f2bcc0 285 SUPERFAMILY SSF88713 42 214 2.72E-39 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS16570 3b065a78f53fd80279f71571c3f2bcc0 285 Pfam PF01522 Polysaccharide deacetylase 81 210 6.5E-33 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS41525 7e01694e42b6858cf287e27595f4b9aa 223 SUPERFAMILY SSF48498 102 168 3.37E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41525 7e01694e42b6858cf287e27595f4b9aa 223 Gene3D G3DSA:1.10.357.10 9 178 5.3E-25 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41525 7e01694e42b6858cf287e27595f4b9aa 223 SUPERFAMILY SSF46689 11 77 3.34E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41525 7e01694e42b6858cf287e27595f4b9aa 223 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 65 4.3E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 SUPERFAMILY SSF51735 126 303 3.94E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 SMART SM00829 22 335 1.2E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 SUPERFAMILY SSF50129 6 144 8.67E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 Gene3D G3DSA:3.90.180.10 5 143 1.6E-55 T 17-03-2017 IPR011032 GroES-like SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 Gene3D G3DSA:3.40.50.720 144 304 1.7E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 Pfam PF00107 Zinc-binding dehydrogenase 161 288 1.2E-23 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS20450 ca3aafb3db7b8c6ab24091805149c1b6 339 Pfam PF16884 N-terminal domain of oxidoreductase 9 115 1.5E-41 T 17-03-2017 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 Gene3D G3DSA:1.10.10.60 551 594 6.3E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 Gene3D G3DSA:3.40.50.300 359 452 5.9E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 SUPERFAMILY SSF46689 505 594 2.82E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 Gene3D G3DSA:1.10.8.60 467 521 8.1E-11 T 17-03-2017 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 SMART SM00382 347 459 0.0035 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 SUPERFAMILY SSF52540 327 524 9.8E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 Pfam PF02954 Bacterial regulatory protein, Fis family 552 591 7.1E-13 T 17-03-2017 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 557 574 6.4E-10 T 17-03-2017 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 PRINTS PR01590 FIS bacterial regulatory protein HTH signature 574 594 6.4E-10 T 17-03-2017 IPR002197 DNA binding HTH domain, Fis-type GO:0043565 SHXM_RS07665 70ed7519f63ffb81b7ae321b50da3876 596 Gene3D G3DSA:3.40.50.300 326 358 6.0E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 Pfam PF00072 Response regulator receiver domain 7 114 1.5E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 SUPERFAMILY SSF46894 139 233 1.45E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 Gene3D G3DSA:3.40.50.2300 4 123 2.0E-33 T 17-03-2017 SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 Gene3D G3DSA:1.10.10.10 137 236 7.0E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 SMART SM00862 158 233 2.2E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 Pfam PF00486 Transcriptional regulatory protein, C terminal 160 231 8.1E-22 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 SMART SM00448 5 115 1.2E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22815 230c54fe3ebe81e01f9f13a1ba9709b2 240 SUPERFAMILY SSF52172 4 174 3.13E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS04905 87d0c6cc773908c663109527f7e5520e 137 Pfam PF13811 Domain of unknown function (DUF4186) 22 129 8.9E-46 T 17-03-2017 IPR020378 Protein of unknown function DUF4186 SHXM_RS04905 87d0c6cc773908c663109527f7e5520e 137 ProDom PD076485 YNEG CYTOPLASMIC ECS2130 STY1535 24 128 5.0E-28 T 17-03-2017 IPR020378 Protein of unknown function DUF4186 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 SUPERFAMILY SSF54427 188 303 1.76E-12 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS16480 282b24656398e5115220f00255b00a80 311 SUPERFAMILY SSF88946 23 109 1.53E-13 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 Pfam PF04542 Sigma-70 region 2 29 91 1.4E-13 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 SUPERFAMILY SSF88659 100 179 2.62E-12 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 Gene3D G3DSA:1.10.10.10 123 177 4.0E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16480 282b24656398e5115220f00255b00a80 311 Gene3D G3DSA:3.10.450.50 188 291 3.9E-11 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS16480 282b24656398e5115220f00255b00a80 311 Gene3D G3DSA:1.10.1740.10 24 108 6.2E-13 T 17-03-2017 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 26 176 2.0E-16 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 Pfam PF08281 Sigma-70, region 4 124 174 8.9E-13 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS16480 282b24656398e5115220f00255b00a80 311 Pfam PF12680 SnoaL-like domain 194 269 3.3E-6 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 144 172 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 Gene3D G3DSA:3.40.50.720 3 252 2.2E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 192 5.7E-4 T 17-03-2017 SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 250 1.2E-59 T 17-03-2017 SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 6.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 6.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 6.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 SUPERFAMILY SSF51735 6 251 2.74E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 5.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 5.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 5.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 5.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 214 234 5.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14265 679c2907d9ef57eef3c4643c26710f42 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 SUPERFAMILY SSF56059 83 353 4.07E-62 T 17-03-2017 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 Pfam PF00289 Biotin carboxylase, N-terminal domain 1 110 4.0E-44 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 115 330 3.6E-71 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 Gene3D G3DSA:3.30.1490.20 130 201 1.4E-24 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 Gene3D G3DSA:3.40.50.20 1 129 2.7E-50 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 Pfam PF02785 Biotin carboxylase C-terminal domain 344 456 4.0E-31 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 SMART SM00878 344 456 6.8E-46 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 SUPERFAMILY SSF51246 339 459 1.1E-32 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 Gene3D G3DSA:3.30.470.20 203 458 4.2E-90 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 288 295 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS22605 cd4530986ef131fe541f4b3ab3dffc5c 554 SUPERFAMILY SSF52440 1 113 1.37E-47 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2299 2597 2.0E-122 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 571 869 3.9E-122 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2144 2261 2.1E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 411 531 7.7E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1695 1710 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF47336 3224 3306 7.85E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF51735 1223 1366 1.12E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF51735 2940 3156 1.51E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2024 2141 5.8E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 290 408 5.9E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF52151 2296 2424 1.96E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF52151 2489 2588 1.96E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF53901 30 405 4.72E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1929 1945 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.47.10 2029 2195 6.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.47.10 295 462 2.4E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3256 3271 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.30.70.250 2423 2487 3.9E-8 T 17-03-2017 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.30.70.250 695 759 5.6E-7 T 17-03-2017 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM01294 3230 3297 1.0E-5 T 17-03-2017 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM01294 1669 1736 3.0E-4 T 17-03-2017 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF55048 695 760 2.75E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.366.10 760 870 4.4E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.366.10 2488 2598 2.9E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.366.10 2297 2418 2.9E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.366.10 569 690 4.4E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF00698 Acyl transferase domain 569 887 1.4E-90 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF00698 Acyl transferase domain 2297 2615 5.8E-94 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.47.10 29 294 3.5E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.47.10 1763 2028 2.0E-96 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF51735 1381 1631 5.67E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF14765 Polyketide synthase dehydratase 936 1215 1.8E-53 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00826 936 1101 8.4E-80 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:1.10.1200.10 3226 3300 6.8E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:1.10.1200.10 1665 1740 3.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF08659 KR domain 1382 1561 2.6E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF08659 KR domain 2942 3119 2.1E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF47336 1665 1780 1.83E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2942 3121 2.2E-60 T 17-03-2017 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1382 1562 2.2E-54 T 17-03-2017 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF00550 Phosphopantetheine attachment site 1685 1736 9.1E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF00550 Phosphopantetheine attachment site 3232 3297 1.9E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 195 211 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1765 2016 5.5E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 33 282 2.3E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF55048 2423 2488 2.22E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.50.720 2943 3167 1.0E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Gene3D G3DSA:3.40.50.720 1383 1566 4.6E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00823 Phosphopantetheine attachment site 1668 1740 4.3E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00823 Phosphopantetheine attachment site 3229 3301 4.8E-27 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF52151 568 696 3.66E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF52151 761 859 3.66E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 Pfam PF08990 Erythronolide synthase docking 3 26 1.5E-8 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF53901 1763 2139 3.64E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00825 Beta-ketoacyl synthase 1767 2194 1.7E-228 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SMART SM00825 Beta-ketoacyl synthase 35 461 3.5E-225 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45355 1924a53cfd06966b3ff0de8be35611e9 3380 SUPERFAMILY SSF51735 2714 2929 7.68E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42985 94ba03e521722b24a664109e08489319 762 ProSitePatterns PS01047 Heavy-metal-associated domain. 16 44 - T 17-03-2017 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 158 738 1.4E-165 T 17-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Gene3D G3DSA:3.40.1110.10 456 563 2.9E-13 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Pfam PF00702 haloacid dehalogenase-like hydrolase 435 650 3.9E-40 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF56784 438 457 2.43E-53 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF56784 499 736 2.43E-53 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF81653 244 339 2.22E-20 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Pfam PF00403 Heavy-metal-associated domain 15 72 3.2E-13 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF81665 340 433 1.83E-8 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF81665 685 712 1.83E-8 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF81665 232 243 1.83E-8 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00943 Copper-transporting ATPase signature 53 73 2.1E-7 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00943 Copper-transporting ATPase signature 613 630 2.1E-7 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00943 Copper-transporting ATPase signature 670 684 2.1E-7 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00943 Copper-transporting ATPase signature 143 162 2.1E-7 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00943 Copper-transporting ATPase signature 362 376 2.1E-7 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 636 655 9.1E-23 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 439 453 9.1E-23 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 289 303 9.1E-23 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 659 671 9.1E-23 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 583 593 9.1E-23 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 TIGRFAM TIGR01511 ATPase-IB1_Cu: copper-translocating P-type ATPase 200 739 2.0E-143 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 ProSitePatterns PS01229 Hypothetical cof family signature 2. 636 658 - T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Gene3D G3DSA:3.30.70.100 12 88 7.0E-23 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 TIGRFAM TIGR01512 ATPase-IB2_Cd: cadmium-translocating P-type ATPase 203 738 3.4E-108 T 17-03-2017 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Gene3D G3DSA:3.40.50.1000 564 704 3.9E-47 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Gene3D G3DSA:3.40.50.1000 411 455 3.9E-47 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42985 94ba03e521722b24a664109e08489319 762 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 215 459 3.9E-36 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 547 723 3.9E-38 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Gene3D G3DSA:2.70.150.10 209 339 1.4E-19 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 441 447 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 Pfam PF00122 E1-E2 ATPase 213 430 2.8E-57 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS42985 94ba03e521722b24a664109e08489319 762 SUPERFAMILY SSF55008 12 78 3.93E-18 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 PIRSF PIRSF037434 10 402 2.5E-68 T 17-03-2017 IPR017205 Signal transduction histidine kinase, ChrS SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 SUPERFAMILY SSF55874 275 395 1.35E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 SMART SM00387 307 398 6.6E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 Pfam PF07730 Histidine kinase 201 263 3.0E-18 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 310 395 3.7E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 PRINTS PR00344 Bacterial sensor protein C-terminal signature 382 395 3.2E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 PRINTS PR00344 Bacterial sensor protein C-terminal signature 358 376 3.2E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 PRINTS PR00344 Bacterial sensor protein C-terminal signature 343 357 3.2E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS28895 b06d1ee743a553c448558929ec0f662a 402 Gene3D G3DSA:3.30.565.10 276 398 1.8E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 SUPERFAMILY SSF81653 143 238 3.4E-21 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00941 Cadmium-transporting ATPase signature 122 142 4.9E-5 T 17-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00941 Cadmium-transporting ATPase signature 204 220 4.9E-5 T 17-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 SUPERFAMILY SSF56784 397 437 3.37E-45 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 SUPERFAMILY SSF56784 488 673 3.37E-45 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 SUPERFAMILY SSF56784 337 356 3.37E-45 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 TIGRFAM TIGR01525 ATPase-IB_hvy: heavy metal translocating P-type ATPase 87 676 2.5E-165 T 17-03-2017 IPR027256 P-type ATPase, subfamily IB GO:0006812|GO:0016021|GO:0019829 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 SUPERFAMILY SSF81665 89 141 6.93E-12 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 SUPERFAMILY SSF81665 239 332 6.93E-12 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 338 352 2.5E-17 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 597 609 2.5E-17 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 188 202 2.5E-17 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 573 592 2.5E-17 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 520 530 2.5E-17 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 Gene3D G3DSA:3.40.50.1000 316 354 4.0E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 Gene3D G3DSA:3.40.50.1000 498 639 4.0E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 473 640 1.8E-30 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 111 373 1.2E-32 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 Gene3D G3DSA:2.70.150.10 90 239 1.0E-23 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 Gene3D G3DSA:3.40.1110.10 357 497 1.5E-17 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 ProSitePatterns PS01229 Hypothetical cof family signature 2. 573 595 - T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 340 346 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 Pfam PF00702 haloacid dehalogenase-like hydrolase 337 586 3.0E-36 T 17-03-2017 SHXM_RS05935 ed33b271551a92566d590a1bb54afedb 695 Pfam PF00122 E1-E2 ATPase 108 329 2.0E-52 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 42 266 1.7E-47 T 17-03-2017 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 Reactome: R-HSA-196843 SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 TIGRFAM TIGR02039 CysD: sulfate adenylyltransferase, small subunit 21 312 1.5E-139 T 17-03-2017 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 SUPERFAMILY SSF52402 18 219 6.05E-63 T 17-03-2017 SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 PIRSF PIRSF002936 13 312 4.4E-138 T 17-03-2017 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 Hamap MF_00064 Sulfate adenylyltransferase subunit 2 [cysD]. 16 312 53.463 T 17-03-2017 IPR011784 Sulphate adenylyltransferase, small subunit GO:0004781|GO:0019419 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 Gene3D G3DSA:3.40.50.620 253 261 2.1E-52 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS38730 621ca559ea7cd27509c2841d69f76cda 312 Gene3D G3DSA:3.40.50.620 17 220 2.1E-52 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 Pfam PF00005 ABC transporter 491 641 1.4E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 Gene3D G3DSA:1.20.1560.10 149 461 3.7E-46 T 17-03-2017 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 Gene3D G3DSA:3.90.70.10 6 129 1.5E-19 T 17-03-2017 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 Gene3D G3DSA:3.40.50.300 474 702 2.8E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 Pfam PF03412 Peptidase C39 family 1 130 2.4E-37 T 17-03-2017 IPR005074 Peptidase C39, bacteriocin processing GO:0005524|GO:0006508|GO:0008233|GO:0016021 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 Pfam PF00664 ABC transporter transmembrane region 157 425 1.4E-23 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 SUPERFAMILY SSF90123 147 461 1.57E-45 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 TIGRFAM TIGR03796 NHLM_micro_ABC1: NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein 1 707 2.8E-299 T 17-03-2017 IPR022514 NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 ProSitePatterns PS00211 ABC transporters family signature. 613 627 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 SUPERFAMILY SSF52540 467 707 1.93E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04200 5eee575120dec0483bf27e0a54fd431c 709 SMART SM00382 500 685 3.5E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS27895 00b727027ced9c93be5086ee45766da0 210 Gene3D G3DSA:3.40.50.1000 64 193 2.1E-14 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27895 00b727027ced9c93be5086ee45766da0 210 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 5 172 4.6E-17 T 17-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 SHXM_RS27895 00b727027ced9c93be5086ee45766da0 210 Pfam PF12710 haloacid dehalogenase-like hydrolase 6 170 2.1E-11 T 17-03-2017 SHXM_RS27895 00b727027ced9c93be5086ee45766da0 210 SUPERFAMILY SSF56784 6 206 2.58E-20 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 Gene3D G3DSA:3.40.50.2300 61 168 1.5E-34 T 17-03-2017 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 Gene3D G3DSA:3.40.50.2300 169 332 1.3E-52 T 17-03-2017 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 Pfam PF13377 Periplasmic binding protein-like domain 169 332 1.4E-35 T 17-03-2017 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 47 3.0E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 SUPERFAMILY SSF47413 1 59 2.06E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 SMART SM00354 1 71 4.0E-25 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 Gene3D G3DSA:1.10.260.40 3 60 7.1E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 13 23 8.9E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 3 13 8.9E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 ProSitePatterns PS00356 LacI-type HTH domain signature. 4 22 - T 17-03-2017 SHXM_RS11355 6f1e3d80deb612f17fdb6d5a3827543c 339 SUPERFAMILY SSF53822 61 335 9.42E-71 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS17055 b4f1a2fe7059b24ab3515ec2b61de7f7 120 ProDom PD031888 MUTASE CHORISMATE AROH THE CLASS ISOMERASE TRANSCRIPTION BIOSYNTHESIS CM 3D-STRUCTURE 9 118 1.0E-47 T 17-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS17055 b4f1a2fe7059b24ab3515ec2b61de7f7 120 PIRSF PIRSF005965 1 120 1.7E-42 T 17-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS17055 b4f1a2fe7059b24ab3515ec2b61de7f7 120 TIGRFAM TIGR01796 CM_mono_aroH: chorismate mutase 3 118 1.4E-49 T 17-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS17055 b4f1a2fe7059b24ab3515ec2b61de7f7 120 SUPERFAMILY SSF55298 2 118 4.79E-41 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS17055 b4f1a2fe7059b24ab3515ec2b61de7f7 120 Gene3D G3DSA:3.30.1330.40 3 119 6.5E-45 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS17055 b4f1a2fe7059b24ab3515ec2b61de7f7 120 Pfam PF07736 Chorismate mutase type I 3 118 7.9E-42 T 17-03-2017 IPR008243 Chorismate mutase, AroH class KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS43690 0d8520981d52a740a4ce60ead9b5edd1 305 TIGRFAM TIGR00724 urea_amlyse_rel: biotin-dependent carboxylase uncharacterized domain 8 286 6.7E-77 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS43690 0d8520981d52a740a4ce60ead9b5edd1 305 SUPERFAMILY SSF50891 176 289 1.14E-14 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS43690 0d8520981d52a740a4ce60ead9b5edd1 305 Pfam PF02626 Allophanate hydrolase subunit 2 28 284 5.2E-83 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS43690 0d8520981d52a740a4ce60ead9b5edd1 305 Gene3D G3DSA:2.40.100.10 176 288 7.2E-10 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS43690 0d8520981d52a740a4ce60ead9b5edd1 305 SMART SM00797 27 300 1.7E-96 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 SMART SM00054 45 72 27.0 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 SMART SM00054 8 36 0.0061 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 ProSitePatterns PS00018 EF-hand calcium-binding domain. 17 29 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 SUPERFAMILY SSF47473 5 71 8.1E-17 T 17-03-2017 IPR011992 EF-hand domain pair SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 ProSitePatterns PS00018 EF-hand calcium-binding domain. 54 66 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 Pfam PF13499 EF-hand domain pair 8 70 2.9E-13 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS42675 ea480a91cc27b92cd225ae2a8ca52292 72 Gene3D G3DSA:1.10.238.10 7 71 6.3E-17 T 17-03-2017 IPR011992 EF-hand domain pair SHXM_RS34560 2f2d98fa188de2e5b294f27bc4f4ac95 186 Gene3D G3DSA:1.10.357.10 5 181 4.2E-16 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34560 2f2d98fa188de2e5b294f27bc4f4ac95 186 SUPERFAMILY SSF46689 7 72 5.64E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 Gene3D G3DSA:2.60.420.10 682 753 3.1E-22 T 17-03-2017 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 PIRSF PIRSF036289 1 762 1.4E-217 T 17-03-2017 IPR017045 Maltose phosphorylase/glycosyl hydrolase/vacuolar acid trehalase SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 Pfam PF03633 Glycosyl hydrolase family 65, C-terminal domain 700 750 4.1E-15 T 17-03-2017 IPR005194 Glycoside hydrolase family 65, C-terminal SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 SUPERFAMILY SSF48208 279 748 1.25E-122 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 Gene3D G3DSA:2.70.98.40 5 270 1.3E-75 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 Pfam PF03632 Glycosyl hydrolase family 65 central catalytic domain 327 695 2.3E-135 T 17-03-2017 IPR005195 Glycoside hydrolase, family 65, central catalytic GO:0003824|GO:0005975 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 Pfam PF03636 Glycosyl hydrolase family 65, N-terminal domain 16 270 2.1E-61 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 SUPERFAMILY SSF74650 7 270 1.69E-65 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS13925 9d0ba018206d01e32dbd616b3a43ea0a 781 Gene3D G3DSA:1.50.10.10 321 681 2.2E-129 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS41040 4b45c2973619f453b1714d3442c70329 318 Gene3D G3DSA:3.20.20.370 23 298 1.9E-78 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS41040 4b45c2973619f453b1714d3442c70329 318 SUPERFAMILY SSF88713 27 298 1.74E-65 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS41040 4b45c2973619f453b1714d3442c70329 318 Pfam PF01522 Polysaccharide deacetylase 46 183 3.1E-20 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 Pfam PF00128 Alpha amylase, catalytic domain 251 341 2.5E-6 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 SUPERFAMILY SSF81296 51 195 5.2E-36 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 Gene3D G3DSA:2.60.40.1180 653 764 8.6E-24 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 Gene3D G3DSA:2.60.40.10 51 215 1.7E-46 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 SMART SM00642 221 632 3.8E-8 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 56 147 1.0E-18 T 17-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 TIGRFAM TIGR02100 glgX_debranch: glycogen debranching enzyme GlgX 53 763 1.8E-301 T 17-03-2017 IPR011837 Glycogen debranching enzyme, GlgX type GO:0004133|GO:0004553|GO:0005980 SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 SUPERFAMILY SSF51445 200 533 2.54E-134 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 SUPERFAMILY SSF51445 562 640 2.54E-134 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 Gene3D G3DSA:3.20.20.80 216 640 4.8E-124 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS35850 cd0764c20b03e46bbcbd5e32a16a3be2 775 SUPERFAMILY SSF51011 653 764 5.54E-19 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:1.10.1200.10 425 496 1.6E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SMART SM00823 Phosphopantetheine attachment site 1508 1579 0.54 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SMART SM00823 Phosphopantetheine attachment site 426 497 8.6E-18 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF52777 705 947 7.0E-37 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Pfam PF00550 Phosphopantetheine attachment site 1510 1578 3.2E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Pfam PF00550 Phosphopantetheine attachment site 429 493 2.8E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:3.40.50.980 1132 1306 3.1E-46 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF47336 425 514 7.33E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Pfam PF13193 AMP-binding enzyme C-terminal domain 1398 1469 5.3E-12 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:1.10.1200.10 1512 1579 3.2E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Pfam PF00668 Condensation domain 525 820 1.0E-44 T 17-03-2017 IPR001242 Condensation domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:2.30.38.10 1307 1380 8.5E-23 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:3.30.300.30 1385 1511 2.4E-34 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF51735 5 91 9.71E-5 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Pfam PF08659 KR domain 113 289 1.0E-41 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF52777 523 718 2.78E-34 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF47336 1502 1578 1.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:3.40.50.980 976 1131 1.5E-36 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1000 1414 2.0E-122 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF56801 969 1521 1.7E-148 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 113 291 9.8E-35 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 ProSitePatterns PS00012 Phosphopantetheine attachment site. 452 467 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SMART SM01294 427 493 1.4E-9 T 17-03-2017 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Gene3D G3DSA:3.40.50.720 112 274 9.3E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1126 1137 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 Pfam PF00501 AMP-binding enzyme 986 1390 2.8E-94 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10760 8f1b845173cea6b3cbead85edf707485 1579 SUPERFAMILY SSF51735 111 297 2.8E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 SUPERFAMILY SSF46785 1 85 4.89E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 2.1E-25 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 Gene3D G3DSA:3.40.190.10 175 262 1.1E-25 T 17-03-2017 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 SUPERFAMILY SSF53850 89 292 2.17E-42 T 17-03-2017 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 2.5E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 2.5E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 2.5E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 Gene3D G3DSA:3.40.190.10 90 174 8.5E-21 T 17-03-2017 SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 Gene3D G3DSA:1.10.10.10 1 85 2.3E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03345 f4bdd630c0f52d741fc4ec535884b2eb 306 Pfam PF03466 LysR substrate binding domain 88 291 3.9E-44 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1351 1531 1.6E-56 T 17-03-2017 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 409 1.9E-40 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1985 2100 2.5E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF55048 2391 2451 2.88E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF55048 686 749 7.85E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF53901 33 402 1.52E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 528 1.5E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2103 2221 5.5E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF47336 2654 2737 3.93E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF53901 1724 2098 1.02E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00826 927 1079 4.9E-26 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2257 2560 1.4E-119 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 566 859 2.3E-111 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1890 1906 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF51735 1351 1570 7.83E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF51735 1169 1340 2.17E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.47.10 1990 2153 3.6E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.47.10 300 461 9.5E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.47.10 39 298 1.3E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.47.10 1729 1989 4.1E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00823 Phosphopantetheine attachment site 1636 1708 6.4E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00823 Phosphopantetheine attachment site 2661 2733 4.0E-24 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF52151 562 687 3.66E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF52151 751 847 3.66E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1663 1678 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF47336 1631 1742 1.83E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF08659 KR domain 1351 1530 1.6E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.366.10 2451 2564 2.4E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.366.10 2249 2385 2.4E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00825 Beta-ketoacyl synthase 1729 2153 1.2E-213 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM00825 Beta-ketoacyl synthase 38 462 2.7E-217 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.30.70.250 686 742 2.5E-6 T 17-03-2017 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.30.70.250 2391 2450 7.8E-9 T 17-03-2017 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF00550 Phosphopantetheine attachment site 2664 2729 1.8E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF00550 Phosphopantetheine attachment site 1638 1704 8.2E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.50.720 1351 1556 7.2E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.366.10 554 682 1.4E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:3.40.366.10 750 872 1.4E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 286 8.7E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1727 1977 5.4E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:1.10.1200.10 2660 2731 2.5E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Gene3D G3DSA:1.10.1200.10 1634 1708 3.9E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF52151 2253 2391 4.19E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SUPERFAMILY SSF52151 2452 2548 4.19E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM01294 1641 1704 2.4E-4 T 17-03-2017 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 SMART SM01294 2662 2729 1.4E-4 T 17-03-2017 SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF00698 Acyl transferase domain 564 878 2.6E-81 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46780 d6b91f2d64431fffb15c6b3c9aa14e3a 2806 Pfam PF00698 Acyl transferase domain 2257 2579 2.8E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS11435 3a15d486e0b1294f86afa95a47552727 533 Gene3D G3DSA:3.40.710.10 237 530 6.0E-53 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS11435 3a15d486e0b1294f86afa95a47552727 533 Pfam PF00905 Penicillin binding protein transpeptidase domain 257 530 3.3E-37 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS11435 3a15d486e0b1294f86afa95a47552727 533 SUPERFAMILY SSF56601 238 530 5.98E-51 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 Pfam PF01979 Amidohydrolase family 56 427 3.2E-24 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 TIGRFAM TIGR03178 allantoinase: allantoinase 7 450 1.1E-180 T 17-03-2017 IPR017593 Allantoinase GO:0000256|GO:0004038|GO:0008270|GO:0050897 KEGG: 00230+3.5.2.5|MetaCyc: PWY-5697|MetaCyc: PWY-5698 SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 SUPERFAMILY SSF51338 7 59 3.67E-25 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 SUPERFAMILY SSF51338 375 436 3.67E-25 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 Gene3D G3DSA:3.20.20.140 73 396 1.0E-125 T 17-03-2017 SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 Gene3D G3DSA:2.30.40.10 8 72 3.8E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS39000 17ba534d740bf5a2040299d7965ef92f 455 SUPERFAMILY SSF51556 60 375 3.41E-97 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS50100 50ee71c4fe9b594881ace5431654d837 326 Gene3D G3DSA:3.40.47.10 3 160 1.8E-50 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50100 50ee71c4fe9b594881ace5431654d837 326 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 236 325 2.4E-24 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS50100 50ee71c4fe9b594881ace5431654d837 326 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 105 184 7.3E-24 T 17-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS50100 50ee71c4fe9b594881ace5431654d837 326 Gene3D G3DSA:3.40.47.10 161 325 3.5E-40 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50100 50ee71c4fe9b594881ace5431654d837 326 SUPERFAMILY SSF53901 2 325 9.33E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 SUPERFAMILY SSF54631 75 211 9.98E-29 T 17-03-2017 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 PIRSF PIRSF000130 7 500 1.3E-201 T 17-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 ProSitePatterns PS00487 IMP dehydrogenase / GMP reductase signature. 301 313 - T 17-03-2017 IPR015875 IMP dehydrogenase / GMP reductase, conserved site GO:0016491|GO:0055114 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 SUPERFAMILY SSF51412 11 98 2.22E-118 T 17-03-2017 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 SUPERFAMILY SSF51412 224 490 2.22E-118 T 17-03-2017 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 Pfam PF00571 CBS domain 157 212 1.7E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 Pfam PF00571 CBS domain 101 149 6.3E-8 T 17-03-2017 IPR000644 CBS domain SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 16 486 1.9E-157 T 17-03-2017 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 SMART SM00116 165 213 2.1E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 SMART SM00116 104 152 8.0E-8 T 17-03-2017 IPR000644 CBS domain SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 SMART SM01240 15 486 0.0 T 17-03-2017 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 Gene3D G3DSA:3.20.20.70 11 498 1.3E-194 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 Hamap MF_01964 Inosine-5'-monophosphate dehydrogenase [guaB]. 16 499 83.979 T 17-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS31575 c31db28499230aadc618eae1ea0304f8 500 TIGRFAM TIGR01302 IMP_dehydrog: inosine-5'-monophosphate dehydrogenase 16 468 9.8E-184 T 17-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS11450 3f145980dff270b785a2b7066391046d 151 Gene3D G3DSA:3.40.30.10 2 148 5.6E-39 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS11450 3f145980dff270b785a2b7066391046d 151 PIRSF PIRSF000239 1 150 1.9E-21 T 17-03-2017 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS11450 3f145980dff270b785a2b7066391046d 151 Pfam PF00578 AhpC/TSA family 3 125 1.2E-32 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS11450 3f145980dff270b785a2b7066391046d 151 SUPERFAMILY SSF52833 3 148 1.12E-43 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS12535 0af107a469d7099a1f77ebe365c46f54 174 SMART SM01323 1 82 3.0E-19 T 17-03-2017 IPR003849 Preprotein translocase YajC SHXM_RS12535 0af107a469d7099a1f77ebe365c46f54 174 Pfam PF02699 Preprotein translocase subunit 5 78 5.7E-16 T 17-03-2017 IPR003849 Preprotein translocase YajC SHXM_RS12535 0af107a469d7099a1f77ebe365c46f54 174 TIGRFAM TIGR00739 yajC: preprotein translocase, YajC subunit 4 82 9.2E-15 T 17-03-2017 IPR003849 Preprotein translocase YajC SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 Gene3D G3DSA:3.40.50.1240 196 400 3.3E-54 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 Gene3D G3DSA:3.30.420.10 2 140 2.0E-23 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 SMART SM00855 198 355 4.4E-16 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 199 392 2.6E-56 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 PIRSF PIRSF036922 1 400 7.5E-178 T 17-03-2017 IPR014636 RNase H, phosphoglycerate mutase domain-containing SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 Pfam PF13456 Reverse transcriptase-like 10 131 2.7E-17 T 17-03-2017 SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 SUPERFAMILY SSF53098 4 130 2.02E-30 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS19705 3fb06f744702f1d1cf0615c411ebc944 400 SUPERFAMILY SSF53254 197 399 9.82E-53 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 SUPERFAMILY SSF46955 1 103 2.05E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 Gene3D G3DSA:1.10.1660.10 1 103 3.7E-26 T 17-03-2017 SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 Pfam PF00376 MerR family regulatory protein 3 40 7.1E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 SMART SM00422 2 71 4.8E-22 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 3 14 1.2E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 38 58 1.2E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13885 db44af1e76fa63560d138af4eec562e5 278 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 14 27 1.2E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS21180 1529a7bf0cd52b17f88cf60070b845e6 63 Gene3D G3DSA:3.30.160.160 3 49 2.9E-24 T 17-03-2017 IPR010879 Domain of unknown function DUF1508 SHXM_RS21180 1529a7bf0cd52b17f88cf60070b845e6 63 Pfam PF07411 Domain of unknown function (DUF1508) 10 57 3.2E-25 T 17-03-2017 IPR010879 Domain of unknown function DUF1508 SHXM_RS21180 1529a7bf0cd52b17f88cf60070b845e6 63 SUPERFAMILY SSF160113 1 57 1.18E-21 T 17-03-2017 IPR010879 Domain of unknown function DUF1508 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 SMART SM00065 337 513 0.0016 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Gene3D G3DSA:3.30.450.20 215 317 4.0E-5 T 17-03-2017 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Pfam PF13581 Histidine kinase-like ATPase domain 765 871 3.2E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Pfam PF17203 Single cache domain 3 38 169 1.8E-18 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Pfam PF13185 GAF domain 406 502 1.3E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 SUPERFAMILY SSF55781 401 514 7.41E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 SUPERFAMILY SSF55874 796 876 2.76E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 558 752 9.4E-46 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 SUPERFAMILY SSF103190 37 172 1.49E-26 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Gene3D G3DSA:3.30.450.40 339 511 1.6E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 SUPERFAMILY SSF81606 546 751 1.67E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 SMART SM00331 534 752 3.4E-30 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50370 e4734cddc36b4369349945027af816ea 899 Gene3D G3DSA:3.30.450.20 33 175 5.1E-34 T 17-03-2017 SHXM_RS19265 3b8aa22b9da30e7a30f68cd080b09369 276 Gene3D G3DSA:1.10.3720.10 2 263 5.6E-67 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19265 3b8aa22b9da30e7a30f68cd080b09369 276 SUPERFAMILY SSF161098 5 275 1.31E-69 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19265 3b8aa22b9da30e7a30f68cd080b09369 276 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 84 269 5.1E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 TIGRFAM TIGR00465 ilvC: ketol-acid reductoisomerase 15 327 5.7E-133 T 17-03-2017 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 Pfam PF01450 Acetohydroxy acid isomeroreductase, catalytic domain 184 327 4.8E-65 T 17-03-2017 IPR000506 Acetohydroxy acid isomeroreductase C-terminal GO:0004455|GO:0009082|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 Pfam PF07991 Acetohydroxy acid isomeroreductase, NADPH-binding domain 15 178 6.3E-76 T 17-03-2017 IPR013116 Acetohydroxy acid isomeroreductase, NADPH-binding domain KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 Gene3D G3DSA:1.10.1040.10 30 326 8.3E-111 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 SUPERFAMILY SSF48179 184 329 6.12E-69 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 SUPERFAMILY SSF51735 3 183 2.73E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36165 c7080d4ec104872d3d68dc6c3a4e68ef 332 Hamap MF_00435 Ketol-acid reductoisomerase [ilvC]. 2 329 44.83 T 17-03-2017 IPR013023 Ketol-acid reductoisomerase GO:0009082|GO:0016491|GO:0055114 KEGG: 00290+1.1.1.86|KEGG: 00770+1.1.1.86|MetaCyc: PWY-5103|MetaCyc: PWY-7111 SHXM_RS17290 f282bbfab4f6922a238f3e4289204a2d 457 Pfam PF07690 Major Facilitator Superfamily 54 407 5.6E-24 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS17290 f282bbfab4f6922a238f3e4289204a2d 457 Gene3D G3DSA:1.20.1250.20 41 219 9.9E-22 T 17-03-2017 SHXM_RS17290 f282bbfab4f6922a238f3e4289204a2d 457 Gene3D G3DSA:1.20.1250.20 266 446 1.2E-11 T 17-03-2017 SHXM_RS17290 f282bbfab4f6922a238f3e4289204a2d 457 TIGRFAM TIGR00896 CynX: cyanate transporter 40 429 6.1E-126 T 17-03-2017 IPR004747 Cyanate transport system protein GO:0016021 SHXM_RS17290 f282bbfab4f6922a238f3e4289204a2d 457 SUPERFAMILY SSF103473 22 224 1.96E-49 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS17290 f282bbfab4f6922a238f3e4289204a2d 457 SUPERFAMILY SSF103473 255 449 1.96E-49 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49060 f752d39e22d2769564d2fda848141213 229 SUPERFAMILY SSF52317 43 227 2.82E-44 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS49060 f752d39e22d2769564d2fda848141213 229 Pfam PF01965 DJ-1/PfpI family 44 205 9.6E-25 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS49060 f752d39e22d2769564d2fda848141213 229 Gene3D G3DSA:3.40.50.880 43 228 1.1E-58 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 Pfam PF00294 pfkB family carbohydrate kinase 18 286 9.9E-40 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 36 60 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 PIRSF PIRSF000535 1 304 2.3E-79 T 17-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 SUPERFAMILY SSF53613 1 282 1.31E-56 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 242 255 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 Gene3D G3DSA:3.40.1190.20 34 304 1.1E-70 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS48320 a28bb4d1ac5d5d5de048a3c1ecc00203 316 TIGRFAM TIGR03168 1-PFK: hexose kinase, 1-phosphofructokinase family 2 302 1.8E-85 T 17-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 ProSitePatterns PS00655 Glycosyl hydrolases family 6 signature 1. 103 119 - T 17-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 98 111 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 286 300 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 262 282 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 246 259 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 126 141 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 182 195 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 55 74 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PRINTS PR00733 Glycosyl hydrolase family 6 signature 213 223 4.2E-41 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 PIRSF PIRSF001100 8 318 1.0E-86 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 Gene3D G3DSA:3.20.20.40 34 317 1.7E-88 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 SUPERFAMILY SSF51989 35 317 2.09E-85 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 ProSitePatterns PS00656 Glycosyl hydrolases family 6 signature 2. 143 152 - T 17-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 SHXM_RS36200 8ce24bed43936c01ff877a141df4ef4f 318 Pfam PF01341 Glycosyl hydrolases family 6 55 303 2.9E-64 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 SUPERFAMILY SSF101898 163 470 4.71E-34 T 17-03-2017 SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 Pfam PF01436 NHL repeat 229 256 2.3E-5 T 17-03-2017 IPR001258 NHL repeat GO:0005515 SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 Pfam PF01436 NHL repeat 400 427 2.4E-4 T 17-03-2017 IPR001258 NHL repeat GO:0005515 SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 Pfam PF13905 Thioredoxin-like 33 127 2.2E-12 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 Gene3D G3DSA:3.40.30.10 9 152 1.8E-39 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 Gene3D G3DSA:2.120.10.30 173 472 1.6E-45 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS28465 521c8e1bb74749f3791b3678eba114bd 604 SUPERFAMILY SSF52833 20 154 6.25E-29 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS24590 daf25941aab2c23f8e03eaa905c105a7 448 Gene3D G3DSA:1.10.630.10 23 408 3.6E-79 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24590 daf25941aab2c23f8e03eaa905c105a7 448 SUPERFAMILY SSF48264 12 407 1.44E-56 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24590 daf25941aab2c23f8e03eaa905c105a7 448 PRINTS PR00359 B-class P450 signature 112 123 1.7E-16 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24590 daf25941aab2c23f8e03eaa905c105a7 448 PRINTS PR00359 B-class P450 signature 158 174 1.7E-16 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24590 daf25941aab2c23f8e03eaa905c105a7 448 PRINTS PR00359 B-class P450 signature 300 327 1.7E-16 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24590 daf25941aab2c23f8e03eaa905c105a7 448 PRINTS PR00359 B-class P450 signature 208 230 1.7E-16 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42085 74e178b72cbac56996aa005d3bfca24f 139 Gene3D G3DSA:3.30.530.20 1 138 2.8E-43 T 17-03-2017 IPR023393 START-like domain SHXM_RS42085 74e178b72cbac56996aa005d3bfca24f 139 SUPERFAMILY SSF55961 1 138 4.79E-34 T 17-03-2017 SHXM_RS42085 74e178b72cbac56996aa005d3bfca24f 139 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 1 138 8.9E-28 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Gene3D G3DSA:3.30.230.10 463 561 2.8E-22 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 SUPERFAMILY SSF54980 563 634 2.06E-6 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Pfam PF03764 Elongation factor G, domain IV 459 559 5.7E-16 T 17-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 51 66 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR01037 Tetracycline resistance protein TetO/TetQ/TetM family signature 532 549 6.5E-18 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR01037 Tetracycline resistance protein TetO/TetQ/TetM family signature 483 497 6.5E-18 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR01037 Tetracycline resistance protein TetO/TetQ/TetM family signature 116 139 6.5E-18 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR01037 Tetracycline resistance protein TetO/TetQ/TetM family signature 228 250 6.5E-18 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 SUPERFAMILY SSF52540 8 254 9.47E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Pfam PF00009 Elongation factor Tu GTP binding domain 9 254 1.2E-52 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Pfam PF00679 Elongation factor G C-terminus 563 634 3.4E-8 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 SUPERFAMILY SSF50447 239 358 4.19E-6 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR00315 GTP-binding elongation factor signature 58 66 2.0E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR00315 GTP-binding elongation factor signature 130 139 2.0E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR00315 GTP-binding elongation factor signature 12 25 2.0E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR00315 GTP-binding elongation factor signature 94 105 2.0E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 PRINTS PR00315 GTP-binding elongation factor signature 78 88 2.0E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 SUPERFAMILY SSF54211 461 560 6.83E-14 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Gene3D G3DSA:3.40.50.300 6 162 6.8E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Gene3D G3DSA:3.30.70.240 562 631 1.1E-6 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 SUPERFAMILY SSF54980 383 442 6.12E-6 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Gene3D G3DSA:3.30.70.870 384 441 1.2E-6 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 SMART SM00889 455 560 1.3E-4 T 17-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 Gene3D G3DSA:2.40.30.10 279 356 2.6E-4 T 17-03-2017 SHXM_RS31975 4c089a6e2721f64f03b00dd74d2bcfcc 651 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 9 141 6.0E-27 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 Gene3D G3DSA:3.90.180.10 1 157 8.5E-34 T 17-03-2017 IPR011032 GroES-like SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 Pfam PF13602 Zinc-binding dehydrogenase 192 312 1.7E-10 T 17-03-2017 SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 SMART SM00829 10 312 4.5E-10 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 SUPERFAMILY SSF51735 123 249 5.99E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 Gene3D G3DSA:3.40.50.720 158 244 2.4E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 SUPERFAMILY SSF50129 1 144 2.28E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS47560 9ec730eca2b69177654fdb3d6d664f81 320 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 92 1.1E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 176 196 5.3E-11 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 63 77 5.3E-11 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 305 316 5.3E-11 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 25 127 2.3E-18 T 17-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 71 84 - T 17-03-2017 IPR033524 Leu/Phe/Val dehydrogenases active site Reactome: R-HSA-70614 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 ProSitePatterns PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 173 189 - T 17-03-2017 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 Gene3D G3DSA:3.40.50.720 155 377 5.1E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 142 377 3.4E-51 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 Gene3D G3DSA:3.40.192.10 5 154 3.4E-37 T 17-03-2017 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 SUPERFAMILY SSF53223 10 144 3.84E-33 T 17-03-2017 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 PIRSF PIRSF000185 11 380 8.7E-101 T 17-03-2017 IPR014362 Glutamate dehydrogenase GO:0016639|GO:0055114 SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 SUPERFAMILY SSF51735 143 377 1.4E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40650 72ef9236de1481d97acf84fd86205534 381 SMART SM00839 143 377 1.2E-77 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 Pfam PF00672 HAMP domain 102 171 2.4E-13 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 SUPERFAMILY SSF158472 123 171 4.45E-5 T 17-03-2017 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 283 390 1.1E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40105 5c254552431ea661e6181038212313e5 417 SMART SM00387 283 393 1.9E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40105 5c254552431ea661e6181038212313e5 417 SUPERFAMILY SSF55874 245 390 2.62E-26 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40105 5c254552431ea661e6181038212313e5 417 SMART SM00388 175 241 8.3E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 SMART SM00304 121 174 4.4E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 Pfam PF00512 His Kinase A (phospho-acceptor) domain 176 241 7.9E-10 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 SUPERFAMILY SSF47384 160 241 1.37E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 Gene3D G3DSA:1.10.287.130 165 237 7.9E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS40105 5c254552431ea661e6181038212313e5 417 Gene3D G3DSA:3.30.565.10 246 390 3.9E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF08659 KR domain 1466 1647 1.5E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF08659 KR domain 3265 3443 2.9E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 580 874 2.3E-124 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2377 2676 1.1E-120 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF52151 2568 2664 7.59E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF52151 2373 2502 7.59E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00550 Phosphopantetheine attachment site 1757 1822 1.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00550 Phosphopantetheine attachment site 3557 3620 5.0E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.47.10 2109 2276 3.2E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.47.10 296 460 9.0E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF47336 1753 1861 1.96E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00824 Thioesterase 3709 3918 1.4E-123 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00975 Thioesterase domain 3716 3916 8.7E-20 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.50.720 3264 3481 1.4E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00825 Beta-ketoacyl synthase 35 461 3.1E-230 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00825 Beta-ketoacyl synthase 1848 2274 4.9E-229 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF53901 30 405 3.79E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.50.720 1465 1665 3.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3265 3445 2.0E-64 T 17-03-2017 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1466 1648 1.6E-58 T 17-03-2017 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:1.10.1200.10 1754 1826 2.7E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:1.10.1200.10 3551 3628 1.5E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.30.70.250 702 763 4.3E-6 T 17-03-2017 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.30.70.250 2500 2566 8.2E-8 T 17-03-2017 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF101173 1 33 3.92E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF53474 3584 3622 5.98E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF53474 3684 3919 5.98E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF51735 1317 1452 5.9E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF51735 1225 1275 5.9E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.366.10 2567 2677 2.1E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.366.10 2373 2496 2.1E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00823 Phosphopantetheine attachment site 3554 3626 5.5E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00823 Phosphopantetheine attachment site 1754 1826 5.8E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.366.10 764 879 2.2E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.366.10 573 698 2.2E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 411 543 1.0E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2224 2339 7.2E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF14765 Polyketide synthase dehydratase 2743 3026 6.6E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF14765 Polyketide synthase dehydratase 941 1216 2.7E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 196 212 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF52151 757 859 2.01E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF52151 577 698 2.01E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.50.1820 3655 3919 1.0E-84 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 33 283 8.2E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1846 2096 1.2E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF55048 702 764 9.68E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM01294 3555 3622 0.0014 T 17-03-2017 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM01294 1755 1822 1.9E-6 T 17-03-2017 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF51735 3032 3244 6.3E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF51735 1464 1678 2.8E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00698 Acyl transferase domain 579 893 1.0E-57 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF00698 Acyl transferase domain 2376 2694 3.8E-86 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2009 2025 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2104 2221 2.7E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 291 408 1.2E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00826 941 1104 4.6E-86 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SMART SM00826 2743 2912 1.3E-90 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1781 1796 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.47.10 35 295 2.7E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Gene3D G3DSA:3.40.47.10 1848 2108 2.9E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF47336 3549 3639 1.44E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF53901 1843 2219 2.28E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF51735 3263 3480 2.61E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 SUPERFAMILY SSF55048 2501 2567 1.83E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22140 f0ce3b986fcfa621f40772945c3dacbc 3920 Pfam PF08990 Erythronolide synthase docking 2 26 2.2E-11 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS12575 dedc4b3cd67a420abe748e6e38a50559 386 Gene3D G3DSA:3.40.50.2000 185 341 5.3E-25 T 17-03-2017 SHXM_RS12575 dedc4b3cd67a420abe748e6e38a50559 386 Pfam PF13439 Glycosyltransferase Family 4 14 173 1.2E-34 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS12575 dedc4b3cd67a420abe748e6e38a50559 386 SUPERFAMILY SSF53756 3 363 2.6E-84 T 17-03-2017 SHXM_RS12575 dedc4b3cd67a420abe748e6e38a50559 386 Pfam PF13692 Glycosyl transferases group 1 188 328 1.2E-29 T 17-03-2017 SHXM_RS24350 747de6bb501a9e2c798a38ce4a52ebe7 322 Gene3D G3DSA:2.60.40.10 91 154 2.8E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 Gene3D G3DSA:2.30.40.10 440 503 6.9E-8 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 Pfam PF07969 Amidohydrolase family 53 498 1.6E-28 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 SUPERFAMILY SSF51556 321 455 1.7E-57 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 SUPERFAMILY SSF51556 59 282 1.7E-57 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 SUPERFAMILY SSF51338 455 507 2.16E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 SUPERFAMILY SSF51338 3 59 2.16E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 Gene3D G3DSA:3.20.20.140 377 439 3.9E-82 T 17-03-2017 SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 Gene3D G3DSA:3.20.20.140 64 274 3.9E-82 T 17-03-2017 SHXM_RS48700 189d01c473c8a9319ed9a6b35d33b235 518 Gene3D G3DSA:2.30.40.10 4 63 4.1E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS00645 c8797392d6949a5c4c91410d08a07b51 388 Gene3D G3DSA:1.10.10.10 56 98 3.5E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00645 c8797392d6949a5c4c91410d08a07b51 388 Gene3D G3DSA:3.30.420.10 232 376 6.0E-10 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00645 c8797392d6949a5c4c91410d08a07b51 388 SUPERFAMILY SSF53098 232 377 6.83E-24 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00645 c8797392d6949a5c4c91410d08a07b51 388 Pfam PF13936 Helix-turn-helix domain 58 99 3.8E-16 T 17-03-2017 IPR025246 Transposase IS30-like HTH domain SHXM_RS00645 c8797392d6949a5c4c91410d08a07b51 388 SUPERFAMILY SSF46689 55 168 5.64E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00645 c8797392d6949a5c4c91410d08a07b51 388 Pfam PF00665 Integrase core domain 232 337 2.0E-11 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS42855 01f625714b97cddd808d74b4c6e28c03 257 SUPERFAMILY SSF54001 1 250 2.45E-63 T 17-03-2017 SHXM_RS42855 01f625714b97cddd808d74b4c6e28c03 257 Pfam PF00797 N-acetyltransferase 20 250 3.1E-46 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS42855 01f625714b97cddd808d74b4c6e28c03 257 Gene3D G3DSA:3.30.2140.10 2 170 5.8E-37 T 17-03-2017 SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 Gene3D G3DSA:3.40.50.720 2 250 5.9E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 SUPERFAMILY SSF51735 5 250 1.13E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 4.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 4.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 4.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 5.2E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 5.2E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 5.2E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.2E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 5.2E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 5.2E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45510 031eadfea3f046cac447fac2eed456eb 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 250 9.4E-50 T 17-03-2017 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 TIGRFAM TIGR00228 ruvC: crossover junction endodeoxyribonuclease RuvC 3 155 2.0E-34 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 Hamap MF_00034 Crossover junction endodeoxyribonuclease RuvC [ruvC]. 1 155 45.368 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 Pfam PF02075 Crossover junction endodeoxyribonuclease RuvC 3 152 8.4E-53 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 Gene3D G3DSA:3.30.420.10 1 156 2.7E-54 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 108 127 1.1E-35 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 140 152 1.1E-35 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 4 17 1.1E-35 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 62 78 1.1E-35 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 PRINTS PR00696 Crossover junction endodeoxyribonuclease RUVC signature 84 100 1.1E-35 T 17-03-2017 IPR002176 Crossover junction endodeoxyribonuclease RuvC GO:0004520|GO:0006281|GO:0006310 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 SUPERFAMILY SSF53098 2 156 1.67E-44 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS12550 561fe3fd45a957259ae5f38369fdf87f 207 ProSitePatterns PS01321 Crossover junction endodeoxyribonuclease ruvC signature. 114 149 - T 17-03-2017 IPR020563 Crossover junction endodeoxyribonuclease RuvC, magnesium-binding site GO:0008821 SHXM_RS45075 2bc71c6d62c8959850e857f224e943d4 421 SUPERFAMILY SSF46785 12 74 7.53E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45075 2bc71c6d62c8959850e857f224e943d4 421 Gene3D G3DSA:3.30.420.40 228 369 2.1E-44 T 17-03-2017 SHXM_RS45075 2bc71c6d62c8959850e857f224e943d4 421 Gene3D G3DSA:3.30.420.40 86 227 2.2E-36 T 17-03-2017 SHXM_RS45075 2bc71c6d62c8959850e857f224e943d4 421 SUPERFAMILY SSF53067 87 397 4.1E-47 T 17-03-2017 SHXM_RS45075 2bc71c6d62c8959850e857f224e943d4 421 Gene3D G3DSA:1.10.10.10 12 80 2.7E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45075 2bc71c6d62c8959850e857f224e943d4 421 Pfam PF00480 ROK family 88 391 4.2E-49 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS33960 ca2373ee320281cccad3ca752f30b3a1 597 Gene3D G3DSA:3.40.190.10 254 370 4.9E-11 T 17-03-2017 SHXM_RS33960 ca2373ee320281cccad3ca752f30b3a1 597 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 118 512 3.7E-60 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS33960 ca2373ee320281cccad3ca752f30b3a1 597 SUPERFAMILY SSF53850 69 586 1.3E-76 T 17-03-2017 SHXM_RS33960 ca2373ee320281cccad3ca752f30b3a1 597 PIRSF PIRSF002741 45 589 1.0E-43 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS33960 ca2373ee320281cccad3ca752f30b3a1 597 Gene3D G3DSA:3.90.76.10 81 253 1.5E-25 T 17-03-2017 SHXM_RS33960 ca2373ee320281cccad3ca752f30b3a1 597 Gene3D G3DSA:3.10.105.10 371 566 3.1E-34 T 17-03-2017 SHXM_RS20415 3594687cc1005022d8b84712f1139997 461 SMART SM00915 331 460 7.7E-8 T 17-03-2017 IPR001229 Jacalin-like lectin domain SHXM_RS20415 3594687cc1005022d8b84712f1139997 461 Pfam PF01419 Jacalin-like lectin domain 373 460 3.5E-9 T 17-03-2017 IPR001229 Jacalin-like lectin domain SHXM_RS20415 3594687cc1005022d8b84712f1139997 461 Gene3D G3DSA:3.60.10.10 57 221 1.7E-5 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS20415 3594687cc1005022d8b84712f1139997 461 SUPERFAMILY SSF56219 54 312 3.27E-43 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS20415 3594687cc1005022d8b84712f1139997 461 Gene3D G3DSA:2.100.10.30 323 460 4.3E-23 T 17-03-2017 IPR001229 Jacalin-like lectin domain SHXM_RS20415 3594687cc1005022d8b84712f1139997 461 SUPERFAMILY SSF51101 323 460 5.63E-24 T 17-03-2017 IPR001229 Jacalin-like lectin domain SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 Hamap MF_00920 Signal recognition particle receptor FtsY [ftsY]. 127 405 58.236 T 17-03-2017 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 SUPERFAMILY SSF52540 204 405 2.99E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 Pfam PF02881 SRP54-type protein, helical bundle domain 115 180 1.2E-12 T 17-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 Gene3D G3DSA:1.20.120.140 129 216 1.2E-26 T 17-03-2017 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 TIGRFAM TIGR00064 ftsY: signal recognition particle-docking protein FtsY 128 403 6.4E-103 T 17-03-2017 IPR004390 Signal-recognition particle receptor FtsY GO:0006614 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 ProSitePatterns PS00300 SRP54-type proteins GTP-binding domain signature. 378 391 - T 17-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 SMART SM00382 205 355 5.2E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 SMART SM00962 206 405 4.6E-101 T 17-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 SMART SM00963 104 184 2.3E-23 T 17-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 Gene3D G3DSA:3.40.50.300 217 405 1.6E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 Pfam PF00448 SRP54-type protein, GTPase domain 207 404 5.0E-73 T 17-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36520 1accbf89db11076cc39c79b691cc4805 406 SUPERFAMILY SSF47364 100 178 1.31E-18 T 17-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 TIGRFAM TIGR01751 crot-CoA-red: crotonyl-CoA carboxylase/reductase 31 427 3.9E-190 T 17-03-2017 IPR010085 Crotonyl-CoA reductase GO:0043880 KEGG: 00650+1.3.1.86 SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 SMART SM00829 49 415 1.0E-10 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 Gene3D G3DSA:3.90.180.10 43 231 6.0E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 Gene3D G3DSA:3.40.50.720 232 364 1.1E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 Pfam PF00107 Zinc-binding dehydrogenase 236 380 2.3E-39 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 SUPERFAMILY SSF51735 198 393 1.81E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 115 189 2.0E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS14730 660b141f06037ce4be03990db88c617e 456 SUPERFAMILY SSF50129 49 230 1.42E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 SUPERFAMILY SSF55781 328 473 1.22E-15 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 SMART SM00331 495 723 1.3E-33 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 Gene3D G3DSA:3.30.450.20 185 291 3.2E-18 T 17-03-2017 SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 SUPERFAMILY SSF55785 187 290 1.45E-10 T 17-03-2017 IPR000014 PAS domain SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 SUPERFAMILY SSF55781 25 156 5.02E-7 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 Gene3D G3DSA:3.30.450.40 24 154 8.9E-9 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 SUPERFAMILY SSF81606 510 675 9.94E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 522 723 1.7E-50 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 Gene3D G3DSA:3.30.450.40 304 480 2.3E-19 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 Pfam PF13185 GAF domain 324 465 1.1E-13 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS16260 49be624d974dce8aee7626694bf64472 850 Pfam PF08448 PAS fold 192 293 6.2E-10 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS46250 dbb7dfa7e11d3be23742b2c11b8fae3e 633 SUPERFAMILY SSF51445 282 479 2.4E-17 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS46250 dbb7dfa7e11d3be23742b2c11b8fae3e 633 Pfam PF14508 Glycosyl-hydrolase 97 N-terminal 53 275 1.8E-34 T 17-03-2017 IPR029486 Glycosyl-hydrolase 97, N-terminal domain SHXM_RS46250 dbb7dfa7e11d3be23742b2c11b8fae3e 633 Gene3D G3DSA:3.20.20.70 314 442 8.9E-9 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS46250 dbb7dfa7e11d3be23742b2c11b8fae3e 633 Pfam PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation 532 618 2.0E-11 T 17-03-2017 IPR029483 Glycosyl-hydrolase 97, C-terminal oligomerisation domain SHXM_RS46250 dbb7dfa7e11d3be23742b2c11b8fae3e 633 Pfam PF10566 Glycoside hydrolase 97 282 530 1.5E-64 T 17-03-2017 IPR019563 Glycosyl-hydrolase 97, catalytic domain SHXM_RS10970 bdf6f34ba087561842094b9a3cba9af5 442 Pfam PF01547 Bacterial extracellular solute-binding protein 60 351 2.6E-38 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS10970 bdf6f34ba087561842094b9a3cba9af5 442 SUPERFAMILY SSF53850 50 435 1.28E-70 T 17-03-2017 SHXM_RS10970 bdf6f34ba087561842094b9a3cba9af5 442 Gene3D G3DSA:3.40.190.10 165 362 5.1E-38 T 17-03-2017 SHXM_RS08610 03023a97a92d9ef30f9e8d5747bafbf2 406 Pfam PF00480 ROK family 107 385 1.1E-34 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS08610 03023a97a92d9ef30f9e8d5747bafbf2 406 Gene3D G3DSA:3.30.420.40 244 368 2.7E-22 T 17-03-2017 SHXM_RS08610 03023a97a92d9ef30f9e8d5747bafbf2 406 Gene3D G3DSA:1.10.10.10 46 98 9.2E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08610 03023a97a92d9ef30f9e8d5747bafbf2 406 Gene3D G3DSA:3.30.420.40 102 243 4.6E-39 T 17-03-2017 SHXM_RS08610 03023a97a92d9ef30f9e8d5747bafbf2 406 SUPERFAMILY SSF46785 46 98 2.13E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08610 03023a97a92d9ef30f9e8d5747bafbf2 406 SUPERFAMILY SSF53067 104 390 1.1E-42 T 17-03-2017 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 Gene3D G3DSA:1.25.40.10 465 586 4.1E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 Gene3D G3DSA:1.25.40.10 587 710 7.4E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 SUPERFAMILY SSF48452 480 688 1.71E-19 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 Pfam PF00931 NB-ARC domain 80 303 2.2E-9 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 SMART SM00028 655 688 0.98 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 SMART SM00028 615 648 400.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 SMART SM00028 535 568 0.12 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 SUPERFAMILY SSF52540 77 309 1.95E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 Pfam PF13424 Tetratricopeptide repeat 506 561 2.6E-7 T 17-03-2017 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 PRINTS PR00364 Disease resistance protein signature 157 171 4.0E-10 T 17-03-2017 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 PRINTS PR00364 Disease resistance protein signature 243 257 4.0E-10 T 17-03-2017 SHXM_RS10265 cc0a3a2bccea98016f7328ae1d2dd6eb 712 PRINTS PR00364 Disease resistance protein signature 79 94 4.0E-10 T 17-03-2017 SHXM_RS05615 1a6e9b0bfba42be80ea4c8e696931605 125 Pfam PF10012 Uncharacterized protein conserved in bacteria (DUF2255) 8 122 6.7E-43 T 17-03-2017 IPR016888 Uncharacterised conserved protein UCP028498 SHXM_RS05615 1a6e9b0bfba42be80ea4c8e696931605 125 Gene3D G3DSA:2.30.110.10 17 52 8.2E-4 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS21055 0661ea270e5179ce2dc4186726935cd9 376 SUPERFAMILY SSF51445 144 312 2.88E-8 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21055 0661ea270e5179ce2dc4186726935cd9 376 Gene3D G3DSA:3.20.20.80 174 313 7.7E-8 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS20700 dd3d91ff8fbef9c0c6a880e4a5375f7a 182 SUPERFAMILY SSF52540 5 176 9.51E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20700 dd3d91ff8fbef9c0c6a880e4a5375f7a 182 Gene3D G3DSA:3.40.50.300 125 156 6.2E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20700 dd3d91ff8fbef9c0c6a880e4a5375f7a 182 Pfam PF03029 Conserved hypothetical ATP binding protein 9 176 3.6E-19 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS20700 dd3d91ff8fbef9c0c6a880e4a5375f7a 182 Gene3D G3DSA:3.40.50.300 5 113 1.9E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23390 210d2a4e78c5d1d595ee81f7656ee45f 77 TIGRFAM TIGR00826 EIIB_glc: PTS system, glucose-like IIB component 3 63 5.8E-17 T 17-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 SHXM_RS23390 210d2a4e78c5d1d595ee81f7656ee45f 77 Gene3D G3DSA:3.30.1360.60 3 77 9.9E-27 T 17-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 SHXM_RS23390 210d2a4e78c5d1d595ee81f7656ee45f 77 Pfam PF00367 phosphotransferase system, EIIB 7 39 1.6E-13 T 17-03-2017 IPR018113 Phosphotransferase system EIIB, cysteine phosphorylation site GO:0008982 SHXM_RS23390 210d2a4e78c5d1d595ee81f7656ee45f 77 SUPERFAMILY SSF55604 5 76 3.66E-21 T 17-03-2017 IPR001996 Phosphotransferase system, IIB component, type 1 GO:0008982|GO:0009401 SHXM_RS01125 d80ca5183157feff3501f666d4566cdb 302 Gene3D G3DSA:3.30.420.10 128 285 2.2E-39 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS01125 d80ca5183157feff3501f666d4566cdb 302 SUPERFAMILY SSF53098 128 290 3.79E-43 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS01125 d80ca5183157feff3501f666d4566cdb 302 Pfam PF00665 Integrase core domain 135 247 1.6E-32 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS01125 d80ca5183157feff3501f666d4566cdb 302 Pfam PF13276 HTH-like domain 53 107 1.1E-14 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS01345 3b67e90a492940d0762c451bfe46a161 220 Pfam PF00857 Isochorismatase family 30 207 9.0E-35 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS01345 3b67e90a492940d0762c451bfe46a161 220 SUPERFAMILY SSF52499 17 212 1.02E-45 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS01345 3b67e90a492940d0762c451bfe46a161 220 Gene3D G3DSA:3.40.50.850 26 216 1.7E-45 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS17865 4002075f805d6f5a6aca2a29c1d4004e 316 ProSitePatterns PS00943 UbiA prenyltransferase family signature. 82 104 - T 17-03-2017 IPR030470 UbiA prenyltransferase conserved site SHXM_RS17865 4002075f805d6f5a6aca2a29c1d4004e 316 Pfam PF01040 UbiA prenyltransferase family 43 298 2.5E-64 T 17-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SHXM_RS17865 4002075f805d6f5a6aca2a29c1d4004e 316 TIGRFAM TIGR01473 cyoE_ctaB: protoheme IX farnesyltransferase 30 312 3.8E-95 T 17-03-2017 IPR006369 Protohaem IX farnesyltransferase GO:0008495|GO:0016021|GO:0048034 Reactome: R-HSA-189451 SHXM_RS17865 4002075f805d6f5a6aca2a29c1d4004e 316 Hamap MF_00154 Protoheme IX farnesyltransferase [cyoE]. 27 314 19.295 T 17-03-2017 IPR006369 Protohaem IX farnesyltransferase GO:0008495|GO:0016021|GO:0048034 Reactome: R-HSA-189451 SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 SUPERFAMILY SSF50129 12 151 8.65E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 SUPERFAMILY SSF51735 118 274 7.08E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 Gene3D G3DSA:3.90.180.10 1 151 1.3E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 146 167 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 Gene3D G3DSA:3.40.50.720 152 235 5.6E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 112 1.4E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 SMART SM00829 12 301 7.9E-19 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS40320 10f0305229fa6f0265a563a4f77e1cec 306 Pfam PF13602 Zinc-binding dehydrogenase 188 290 4.0E-15 T 17-03-2017 SHXM_RS45520 a22fad20b324f7d7ac068eb1a9197b87 103 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 46 1.7E-10 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS45520 a22fad20b324f7d7ac068eb1a9197b87 103 Gene3D G3DSA:1.10.260.40 7 46 1.0E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS45520 a22fad20b324f7d7ac068eb1a9197b87 103 SUPERFAMILY SSF47413 5 47 8.63E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS45520 a22fad20b324f7d7ac068eb1a9197b87 103 SMART SM00354 4 71 1.1E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 Gene3D G3DSA:3.40.50.10210 1118 1374 6.8E-111 T 17-03-2017 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 SUPERFAMILY SSF52733 1048 1392 9.94E-113 T 17-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 Gene3D G3DSA:1.10.1610.10 1046 1117 4.4E-28 T 17-03-2017 IPR023195 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, N-terminal GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 SUPERFAMILY SSF55469 832 1036 1.23E-52 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 Pfam PF00881 Nitroreductase family 836 1003 1.8E-32 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 TIGRFAM TIGR03160 cobT_DBIPRT: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 1058 1391 1.1E-123 T 17-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 Gene3D G3DSA:3.40.109.10 826 1035 3.3E-51 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 Pfam PF02277 Phosphoribosyltransferase 1054 1391 6.7E-125 T 17-03-2017 IPR003200 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase-like GO:0008939|GO:0009236 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 Hamap MF_00230 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [cobT]. 1056 1393 34.678 T 17-03-2017 IPR017846 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, prokaryotic GO:0008939|GO:0009163 KEGG: 00860+2.4.2.21|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS12795 bf5c140ac0d87625a852844bf1206af7 1395 TIGRFAM TIGR02476 BluB: 5,6-dimethylbenzimidazole synthase 824 1029 1.0E-91 T 17-03-2017 IPR012825 5,6-dimethylbenzimidazole synthase BluB KEGG: 00740+1.13.11.79|MetaCyc: PWY-5508|MetaCyc: PWY-5523 SHXM_RS27910 75ad0b0f56175208a00e57b371813c5c 151 Gene3D G3DSA:3.40.630.30 1 150 2.8E-45 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS27910 75ad0b0f56175208a00e57b371813c5c 151 Pfam PF00583 Acetyltransferase (GNAT) family 58 140 3.3E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS27910 75ad0b0f56175208a00e57b371813c5c 151 SUPERFAMILY SSF55729 1 144 1.38E-30 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.40.50.980 3236 3351 7.1E-26 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.30.300.30 2033 2124 2.4E-23 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 898 1163 3.22E-26 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 2223 2400 3.89E-22 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 ProSitePatterns PS00455 Putative AMP-binding domain signature. 284 295 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SMART SM00823 Phosphopantetheine attachment site 2139 2210 4.7E-5 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SMART SM00823 Phosphopantetheine attachment site 3561 3632 8.1E-4 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SMART SM00823 Phosphopantetheine attachment site 650 718 5.7E-6 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1652 2063 3.5E-125 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 3073 3473 2.4E-108 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 166 566 3.7E-117 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.30.300.30 537 654 4.0E-32 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.30.300.30 3446 3563 8.5E-24 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00668 Condensation domain 2263 2494 1.9E-22 T 17-03-2017 IPR001242 Condensation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00668 Condensation domain 750 1024 1.6E-18 T 17-03-2017 IPR001242 Condensation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00668 Condensation domain 2612 2901 6.0E-48 T 17-03-2017 IPR001242 Condensation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00668 Condensation domain 1193 1474 4.3E-43 T 17-03-2017 IPR001242 Condensation domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:2.30.38.10 1952 2029 2.0E-24 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:2.30.38.10 3362 3440 1.1E-24 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:2.30.38.10 452 532 1.2E-23 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF56801 3040 3573 2.22E-124 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.40.50.980 1785 1951 9.8E-46 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.40.50.980 292 442 3.5E-40 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 739 890 1.22E-23 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 1372 1604 1.56E-44 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF47336 2139 2219 7.07E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF13193 AMP-binding enzyme C-terminal domain 2047 2114 3.0E-7 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF13193 AMP-binding enzyme C-terminal domain 551 626 1.7E-11 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF13193 AMP-binding enzyme C-terminal domain 3459 3533 1.5E-9 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1775 1786 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF56801 125 662 6.28E-145 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF47336 643 712 4.97E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3587 3602 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00501 AMP-binding enzyme 1626 2038 5.6E-95 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00501 AMP-binding enzyme 3052 3451 2.0E-84 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00501 AMP-binding enzyme 145 542 5.3E-96 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:1.10.1200.10 655 718 7.2E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:1.10.1200.10 2138 2210 2.5E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:1.10.1200.10 3564 3630 6.7E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00550 Phosphopantetheine attachment site 2144 2206 2.0E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00550 Phosphopantetheine attachment site 3564 3628 3.9E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Pfam PF00550 Phosphopantetheine attachment site 652 713 5.3E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 2618 2789 2.0E-34 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2166 2181 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 2793 3022 9.45E-48 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.40.50.980 3046 3214 4.1E-40 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.40.50.980 1620 1784 6.6E-44 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 Gene3D G3DSA:3.40.50.980 140 291 2.6E-41 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1036 1186 1.3E-34 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 2391 2610 1.78E-16 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF56801 1605 2129 3.92E-145 T 17-03-2017 SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF47336 3556 3631 3.27E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46745 6e3f37a0c5a06d2c5619a57baf6296f8 3632 SUPERFAMILY SSF52777 1192 1382 9.45E-36 T 17-03-2017 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 Pfam PF00365 Phosphofructokinase 2 297 1.8E-102 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 SUPERFAMILY SSF53784 1 337 1.83E-122 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 Hamap MF_01976 Pyrophosphate--fructose 6-phosphate 1-phosphotransferase [pfp]. 1 342 43.741 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 159 175 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 177 194 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 262 284 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 93 109 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 139 157 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 212 224 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 5 24 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 31 44 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 121 138 2.0E-71 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 TIGRFAM TIGR02483 PFK_mixed: phosphofructokinase 2 322 5.3E-155 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 ProSitePatterns PS00433 Phosphofructokinase signature. 266 284 - T 17-03-2017 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 Gene3D G3DSA:3.40.50.450 1 211 4.1E-75 T 17-03-2017 SHXM_RS18755 8f139661f483e5f55d18f2275ed5f9c1 342 PIRSF PIRSF000532 1 340 5.2E-126 T 17-03-2017 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 Pfam PF01433 Peptidase family M1 87 389 7.6E-72 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 SUPERFAMILY SSF63737 5 195 1.83E-37 T 17-03-2017 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 Gene3D G3DSA:1.10.390.10 308 457 8.7E-43 T 17-03-2017 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 Pfam PF11838 ERAP1-like C-terminal domain 535 844 1.5E-61 T 17-03-2017 IPR024571 ERAP1-like C-terminal domain SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 TIGRFAM TIGR02412 pepN_strep_liv: aminopeptidase N 5 850 0.0 T 17-03-2017 IPR012778 Peptidase M1, aminopeptidase GO:0004177|GO:0006508 KEGG: 00480+3.4.11.2|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 261 271 2.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 178 193 2.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 295 310 2.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 135 150 2.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 314 326 2.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21855 858ffe42f6aecbcdd4c65477400b17b9 856 SUPERFAMILY SSF55486 206 456 7.47E-75 T 17-03-2017 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 354 461 5.0E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 Gene3D G3DSA:1.10.287.130 244 300 6.5E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 Pfam PF00512 His Kinase A (phospho-acceptor) domain 253 313 5.8E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 SMART SM00388 252 313 3.2E-10 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 Gene3D G3DSA:3.30.565.10 301 461 1.0E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 SMART SM00387 352 462 5.2E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 SUPERFAMILY SSF47384 235 314 5.69E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 SMART SM00304 197 251 9.6E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 SUPERFAMILY SSF55874 331 462 4.45E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 405 415 2.6E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 422 440 2.6E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 387 401 2.6E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 446 459 2.6E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35395 a4aec92ec70bd1ec427d23a1bf3b95eb 504 Pfam PF00672 HAMP domain 178 247 4.3E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS07625 23c25e4bac5ada7f5a3d99053be82696 451 Pfam PF07730 Histidine kinase 263 329 6.9E-13 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS07625 23c25e4bac5ada7f5a3d99053be82696 451 Gene3D G3DSA:3.30.565.10 370 450 7.2E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07625 23c25e4bac5ada7f5a3d99053be82696 451 SUPERFAMILY SSF55874 347 449 4.45E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07625 23c25e4bac5ada7f5a3d99053be82696 451 Pfam PF13796 Putative sensor 74 235 8.9E-29 T 17-03-2017 IPR025828 Putative sensor domain SHXM_RS20925 089cb5f4919c6fc29fc4d818922e2fa3 403 SUPERFAMILY SSF47413 12 71 7.04E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20925 089cb5f4919c6fc29fc4d818922e2fa3 403 Gene3D G3DSA:1.10.260.40 12 82 2.3E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20925 089cb5f4919c6fc29fc4d818922e2fa3 403 SMART SM00530 15 70 3.9E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS20925 089cb5f4919c6fc29fc4d818922e2fa3 403 Pfam PF13560 Helix-turn-helix domain 12 68 7.9E-10 T 17-03-2017 SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 SUPERFAMILY SSF53901 249 445 5.19E-34 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 Gene3D G3DSA:3.40.47.10 18 292 1.0E-30 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 22 280 1.7E-11 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 176 192 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 288 401 1.6E-11 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 Gene3D G3DSA:3.40.47.10 306 443 8.3E-19 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 SMART SM00825 Beta-ketoacyl synthase 21 425 2.4E-5 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06640 abf8aaaa75479bcea01503e2fd965870 448 SUPERFAMILY SSF53901 19 285 2.39E-27 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 5.5E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2069 2186 8.6E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:1.10.1200.10 3255 3328 4.1E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:1.10.1200.10 1718 1791 1.4E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00825 Beta-ketoacyl synthase 36 462 8.0E-219 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00825 Beta-ketoacyl synthase 1813 2239 4.7E-217 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1746 1761 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF00550 Phosphopantetheine attachment site 3258 3324 4.1E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF00550 Phosphopantetheine attachment site 1721 1779 6.0E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 537 1.1E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2189 2313 1.8E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3283 3298 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF51735 2757 2960 2.24E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00826 939 1101 3.8E-83 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF55048 2475 2535 1.83E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF51735 2968 3212 2.13E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1432 1612 2.1E-56 T 17-03-2017 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2973 3151 2.8E-47 T 17-03-2017 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF47336 1713 1825 8.24E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF08659 KR domain 2973 3149 3.1E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF08659 KR domain 1432 1610 4.8E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.50.720 1432 1614 8.7E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.50.720 2973 3153 1.3E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.47.10 1813 2073 1.1E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 575 872 3.1E-116 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2351 2651 8.6E-107 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF00698 Acyl transferase domain 573 889 2.4E-79 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF00698 Acyl transferase domain 2349 2664 6.6E-79 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF14765 Polyketide synthase dehydratase 939 1216 3.7E-59 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.366.10 563 695 1.2E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.366.10 2541 2664 1.2E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.366.10 2339 2471 1.2E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.366.10 762 885 1.2E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF51735 1428 1612 1.0E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF51735 1224 1416 1.42E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1974 1990 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.30.70.250 2475 2533 1.9E-4 T 17-03-2017 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.30.70.250 699 761 5.7E-5 T 17-03-2017 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF52151 2542 2637 1.05E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF52151 2347 2476 1.05E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00823 Phosphopantetheine attachment site 3256 3328 1.9E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM00823 Phosphopantetheine attachment site 1719 1791 3.9E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF08990 Erythronolide synthase docking 2 26 2.0E-11 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.47.10 31 296 5.3E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.47.10 2074 2240 3.8E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Gene3D G3DSA:3.40.47.10 297 461 9.6E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF52151 763 860 1.6E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF52151 571 700 1.6E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM01294 1720 1787 9.1E-5 T 17-03-2017 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SMART SM01294 3257 3324 7.4E-5 T 17-03-2017 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF53901 31 406 3.85E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF53901 1808 2183 7.33E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 2.0E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1811 2061 2.5E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF47336 3255 3331 2.62E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42865 1d4907c13a2a5785010110bbc73f1b14 3435 SUPERFAMILY SSF55048 699 762 4.97E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS21365 8601ebca4715ef90b13ef1894bf9bb10 176 SUPERFAMILY SSF47598 109 157 1.67E-10 T 17-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 SHXM_RS21365 8601ebca4715ef90b13ef1894bf9bb10 176 Pfam PF05534 HicB family 115 144 3.7E-5 T 17-03-2017 IPR008651 Uncharacterised protein family HicB SHXM_RS21365 8601ebca4715ef90b13ef1894bf9bb10 176 Gene3D G3DSA:1.10.1220.10 111 155 1.2E-8 T 17-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 SUPERFAMILY SSF81606 370 571 1.86E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 Pfam PF00989 PAS fold 27 98 7.1E-8 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 384 572 1.6E-42 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 Gene3D G3DSA:3.30.450.20 23 134 9.7E-14 T 17-03-2017 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 SMART SM00065 158 336 2.8E-4 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 SMART SM00091 23 89 1.2E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 Pfam PF01590 GAF domain 205 326 2.8E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 SMART SM00331 356 572 7.3E-22 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 SUPERFAMILY SSF55785 23 133 2.39E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 28 123 2.6E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 SUPERFAMILY SSF55781 175 338 5.45E-15 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS15695 a6f968ada8d0a6719d82c114b6dad3e2 583 Gene3D G3DSA:3.30.450.40 163 334 3.6E-25 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS45705 cc527b141a7eca5161fb3c3987ab498c 378 Gene3D G3DSA:3.20.20.30 292 363 1.0E-85 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS45705 cc527b141a7eca5161fb3c3987ab498c 378 Gene3D G3DSA:3.20.20.30 14 254 1.0E-85 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS45705 cc527b141a7eca5161fb3c3987ab498c 378 SUPERFAMILY SSF51679 9 361 2.62E-76 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS45705 cc527b141a7eca5161fb3c3987ab498c 378 Pfam PF00296 Luciferase-like monooxygenase 8 330 2.5E-70 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS31435 22c10985de0a1561bb903e731027edee 172 TIGRFAM TIGR00150 T6A_YjeE: tRNA threonylcarbamoyl adenosine modification protein YjeE 13 132 1.0E-25 T 17-03-2017 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 SHXM_RS31435 22c10985de0a1561bb903e731027edee 172 Pfam PF02367 Threonylcarbamoyl adenosine biosynthesis protein TsaE 10 131 7.7E-30 T 17-03-2017 IPR003442 tRNA threonylcarbamoyl adenosine modification protein TsaE GO:0002949 SHXM_RS31435 22c10985de0a1561bb903e731027edee 172 SUPERFAMILY SSF52540 26 119 1.57E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31435 22c10985de0a1561bb903e731027edee 172 Gene3D G3DSA:3.40.50.300 6 163 1.2E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 SUPERFAMILY SSF51306 147 265 2.27E-36 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 PRINTS PR00726 Repressor LexA serine protease (S24) family signature 222 234 2.6E-11 T 17-03-2017 IPR006197 Peptidase S24, LexA-like GO:0003677|GO:0006355 SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 PRINTS PR00726 Repressor LexA serine protease (S24) family signature 183 193 2.6E-11 T 17-03-2017 IPR006197 Peptidase S24, LexA-like GO:0003677|GO:0006355 SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 PRINTS PR00726 Repressor LexA serine protease (S24) family signature 194 205 2.6E-11 T 17-03-2017 IPR006197 Peptidase S24, LexA-like GO:0003677|GO:0006355 SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 SUPERFAMILY SSF46785 61 127 3.21E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 Pfam PF00717 Peptidase S24-like 186 250 1.5E-16 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 Hamap MF_00015 LexA repressor [lexA]. 61 267 34.262 T 17-03-2017 IPR006200 Transcription regulator LexA GO:0004252|GO:0009432|GO:0045892 SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 Gene3D G3DSA:2.10.109.10 148 266 7.6E-45 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 Gene3D G3DSA:1.10.10.10 61 127 1.9E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 Pfam PF01726 LexA DNA binding domain 60 123 1.1E-29 T 17-03-2017 IPR006199 LexA repressor, DNA-binding domain GO:0004252|GO:0006508 SHXM_RS37385 adf5e9b8e819a25941d08fd6406ea15b 267 TIGRFAM TIGR00498 lexA: repressor LexA 60 267 2.3E-75 T 17-03-2017 IPR006200 Transcription regulator LexA GO:0004252|GO:0009432|GO:0045892 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Gene3D G3DSA:3.40.120.10 181 255 5.5E-24 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Gene3D G3DSA:3.30.310.50 375 450 1.2E-18 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 SUPERFAMILY SSF53738 163 261 1.26E-25 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 3 138 9.4E-39 T 17-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 164 259 2.6E-19 T 17-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Hamap MF_01554_B Phosphoglucosamine mutase [glmM]. 1 450 43.916 T 17-03-2017 IPR006352 Phosphoglucosamine mutase, bacterial type GO:0000287|GO:0005975|GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 239 254 2.1E-13 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 179 198 2.1E-13 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 97 111 2.1E-13 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Gene3D G3DSA:3.40.120.10 256 373 8.0E-33 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 TIGRFAM TIGR01455 glmM: phosphoglucosamine mutase 5 448 2.6E-170 T 17-03-2017 IPR006352 Phosphoglucosamine mutase, bacterial type GO:0000287|GO:0005975|GO:0008966 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 98 107 - T 17-03-2017 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 SUPERFAMILY SSF55957 364 452 3.53E-23 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 SUPERFAMILY SSF53738 4 185 1.65E-44 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 263 373 7.6E-33 T 17-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Gene3D G3DSA:3.40.120.10 4 148 1.4E-41 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 381 447 1.6E-14 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS31380 996a6e206b877092f872baae5827a95b 452 SUPERFAMILY SSF53738 263 370 2.0E-29 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS04280 ccd0fff9ab4a428f9b084188ce9efaaa 84 SUPERFAMILY SSF47336 5 70 3.27E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04280 ccd0fff9ab4a428f9b084188ce9efaaa 84 Gene3D G3DSA:1.10.1200.10 7 74 2.2E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04280 ccd0fff9ab4a428f9b084188ce9efaaa 84 Pfam PF00550 Phosphopantetheine attachment site 4 61 2.7E-5 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05630 9cf3d1680b69999ea7252facb809a735 521 Pfam PF09206 Alpha-L-arabinofuranosidase B, catalytic 45 356 8.9E-137 T 17-03-2017 IPR015289 Alpha-L-arabinofuranosidase B, catalytic GO:0031221|GO:0046556 KEGG: 00520+3.2.1.55 SHXM_RS05630 9cf3d1680b69999ea7252facb809a735 521 Gene3D G3DSA:2.80.10.50 366 520 1.2E-47 T 17-03-2017 SHXM_RS05630 9cf3d1680b69999ea7252facb809a735 521 SUPERFAMILY SSF49899 45 357 7.91E-106 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS05630 9cf3d1680b69999ea7252facb809a735 521 SUPERFAMILY SSF110221 365 519 1.31E-51 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS05630 9cf3d1680b69999ea7252facb809a735 521 Gene3D G3DSA:2.60.120.200 44 357 1.1E-133 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS05630 9cf3d1680b69999ea7252facb809a735 521 Pfam PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain 374 515 2.3E-54 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 229 281 2.2E-6 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 SMART SM00382 29 227 1.7E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 SUPERFAMILY SSF52540 4 257 8.22E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 Pfam PF00005 ABC transporter 311 345 9.2E-7 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 Pfam PF00005 ABC transporter 20 177 1.4E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 Gene3D G3DSA:3.40.50.300 4 250 9.3E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 Gene3D G3DSA:3.40.50.300 293 348 5.4E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49825 15f0c3e337c83348d43b9e447f8148ce 380 SUPERFAMILY SSF52540 294 347 8.47E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 SUPERFAMILY SSF53383 70 432 1.02E-56 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 Pfam PF00155 Aminotransferase class I and II 115 428 2.3E-19 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 SMART SM00345 15 74 1.1E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 Gene3D G3DSA:1.10.10.10 14 83 1.8E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 Pfam PF00392 Bacterial regulatory proteins, gntR family 12 74 7.5E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 SUPERFAMILY SSF46785 12 78 2.3E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44025 703db23d620b5230f41c2885491ef26d 442 Gene3D G3DSA:3.40.640.10 127 333 2.0E-34 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS44915 4e9ce39463dc7f47e1bafd384d143b1f 490 SUPERFAMILY SSF53720 16 488 2.36E-163 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS44915 4e9ce39463dc7f47e1bafd384d143b1f 490 Gene3D G3DSA:3.40.309.10 277 461 7.0E-66 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS44915 4e9ce39463dc7f47e1bafd384d143b1f 490 Gene3D G3DSA:3.40.605.10 18 276 2.4E-96 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS44915 4e9ce39463dc7f47e1bafd384d143b1f 490 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 262 269 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS44915 4e9ce39463dc7f47e1bafd384d143b1f 490 Pfam PF00171 Aldehyde dehydrogenase family 26 486 4.3E-162 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 TIGRFAM TIGR01016 sucCoAbeta: succinate-CoA ligase, beta subunit 2 388 6.5E-125 T 17-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 SUPERFAMILY SSF56059 3 226 3.35E-66 T 17-03-2017 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 Gene3D G3DSA:3.30.470.20 88 228 5.1E-52 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 ProSitePatterns PS01217 ATP-citrate lyase / succinyl-CoA ligases family signature 3. 249 273 - T 17-03-2017 IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 Pfam PF08442 ATP-grasp domain 2 194 3.2E-68 T 17-03-2017 IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 Hamap MF_00558 Succinyl-CoA ligase [ADP-forming] subunit beta [sucC]. 1 389 40.465 T 17-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 SUPERFAMILY SSF52210 231 387 1.96E-41 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 Pfam PF00549 CoA-ligase 256 380 1.4E-13 T 17-03-2017 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 Gene3D G3DSA:3.30.1490.20 22 87 2.3E-17 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 PIRSF PIRSF001554 1 390 5.4E-135 T 17-03-2017 IPR005809 Succinyl-CoA synthetase, beta subunit GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS25290 b566f8b688453f36f8be98270fb89d99 390 Gene3D G3DSA:3.40.50.261 232 388 6.1E-53 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS27230 e7d7a89f2bc05063f790cb2c1aca8aab 258 Pfam PF00005 ABC transporter 39 184 8.1E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS27230 e7d7a89f2bc05063f790cb2c1aca8aab 258 Gene3D G3DSA:3.40.50.300 22 237 6.7E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27230 e7d7a89f2bc05063f790cb2c1aca8aab 258 SUPERFAMILY SSF52540 23 241 2.06E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27230 e7d7a89f2bc05063f790cb2c1aca8aab 258 ProSitePatterns PS00211 ABC transporters family signature. 157 171 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS27230 e7d7a89f2bc05063f790cb2c1aca8aab 258 SMART SM00382 48 242 1.9E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 ProSitePatterns PS00622 LuxR-type HTH domain signature. 909 936 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 SMART SM00421 892 949 2.8E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 Gene3D G3DSA:1.10.10.10 892 945 2.3E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 Pfam PF13191 AAA ATPase domain 12 175 3.4E-18 T 17-03-2017 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 SUPERFAMILY SSF46894 889 947 1.6E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 SUPERFAMILY SSF48452 589 688 2.93E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 Gene3D G3DSA:1.25.40.10 592 850 1.1E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 Pfam PF00196 Bacterial regulatory proteins, luxR family 895 945 8.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 925 937 2.4E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 895 909 2.4E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 909 925 2.4E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 Gene3D G3DSA:3.40.50.300 12 69 4.3E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 Gene3D G3DSA:3.40.50.300 120 207 4.3E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 SUPERFAMILY SSF52540 12 80 5.82E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07255 63316fceb4ea3cf93cc2b453ad833c4c 957 SUPERFAMILY SSF52540 124 246 5.82E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49035 1e103bda2336f2b4cefefb2139b83bba 247 Pfam PF01841 Transglutaminase-like superfamily 34 157 9.6E-17 T 17-03-2017 IPR002931 Transglutaminase-like SHXM_RS49035 1e103bda2336f2b4cefefb2139b83bba 247 SUPERFAMILY SSF54001 29 181 8.83E-17 T 17-03-2017 SHXM_RS49035 1e103bda2336f2b4cefefb2139b83bba 247 SMART SM00460 81 159 1.4E-10 T 17-03-2017 IPR002931 Transglutaminase-like SHXM_RS21610 9ad2025eb7478b538073079e3d6f4589 1362 SMART SM00316 715 794 1.9E-5 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS21610 9ad2025eb7478b538073079e3d6f4589 1362 Pfam PF10150 Ribonuclease E/G family 796 1065 2.2E-108 T 17-03-2017 IPR019307 RNA-binding protein AU-1/Ribonuclease E/G GO:0003723 SHXM_RS21610 9ad2025eb7478b538073079e3d6f4589 1362 SUPERFAMILY SSF50249 717 800 6.86E-15 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS21610 9ad2025eb7478b538073079e3d6f4589 1362 Gene3D G3DSA:2.40.50.140 710 800 2.7E-28 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS21610 9ad2025eb7478b538073079e3d6f4589 1362 TIGRFAM TIGR00757 RNaseEG: ribonuclease, Rne/Rng family 692 1092 3.8E-154 T 17-03-2017 IPR004659 Ribonuclease E/G GO:0003723|GO:0004540|GO:0006396 SHXM_RS10630 926abbc1d325e25bf9817e52c82a267d 106 Pfam PF07110 EthD domain 12 83 2.5E-10 T 17-03-2017 IPR009799 EthD domain SHXM_RS10630 926abbc1d325e25bf9817e52c82a267d 106 TIGRFAM TIGR02118 TIGR02118: conserved hypothetical protein 1 89 4.7E-11 T 17-03-2017 IPR009799 EthD domain SHXM_RS10630 926abbc1d325e25bf9817e52c82a267d 106 Gene3D G3DSA:3.30.70.900 1 97 4.6E-21 T 17-03-2017 SHXM_RS10630 926abbc1d325e25bf9817e52c82a267d 106 SUPERFAMILY SSF54909 1 97 1.95E-18 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SMART SM00825 Beta-ketoacyl synthase 333 785 5.8E-35 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Gene3D G3DSA:3.40.47.10 625 784 2.0E-39 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF08659 KR domain 1395 1622 1.6E-19 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 8.9E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 8.9E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 8.9E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 8.9E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 8.9E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 8.9E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1394 1624 1.4E-8 T 17-03-2017 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Gene3D G3DSA:3.40.50.720 1 251 5.1E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 618 729 2.8E-25 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF53901 332 449 2.19E-34 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF53901 496 617 2.19E-34 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Gene3D G3DSA:3.40.50.720 1393 1427 1.4E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Gene3D G3DSA:3.40.50.720 1477 1606 1.4E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 332 400 2.3E-9 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 527 610 1.1E-19 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 857 1015 4.5E-13 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF53901 951 1053 1.2E-25 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF53901 811 924 1.2E-25 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF53901 577 783 3.73E-50 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF51735 1480 1670 6.16E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF51735 1393 1435 6.16E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 250 1.5E-59 T 17-03-2017 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Pfam PF14765 Polyketide synthase dehydratase 1699 1986 2.8E-15 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 SUPERFAMILY SSF51735 6 251 5.67E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Gene3D G3DSA:3.40.47.10 812 1060 2.3E-22 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13375 4af0c1f773c52759bc0746ad12949d47 2011 Gene3D G3DSA:3.40.47.10 333 622 1.2E-40 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31020 d6e6fd1a247f30035549ddb88fe9fac7 222 Pfam PF13460 NAD(P)H-binding 7 194 5.6E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31020 d6e6fd1a247f30035549ddb88fe9fac7 222 SUPERFAMILY SSF51735 1 208 9.6E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31020 d6e6fd1a247f30035549ddb88fe9fac7 222 Gene3D G3DSA:3.40.50.720 1 211 6.6E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 Gene3D G3DSA:3.40.47.10 189 213 4.6E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 Gene3D G3DSA:3.40.47.10 21 109 4.6E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 SUPERFAMILY SSF53901 254 360 2.52E-23 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 PIRSF PIRSF000429 1 379 1.6E-42 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 Pfam PF00108 Thiolase, N-terminal domain 5 167 3.5E-12 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 Gene3D G3DSA:3.40.47.10 256 356 3.2E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 SUPERFAMILY SSF53901 4 220 3.0E-38 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10685 77ee2fe72187d289d8ae00b4024d58f9 381 Pfam PF02803 Thiolase, C-terminal domain 258 353 1.3E-7 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 Pfam PF00069 Protein kinase domain 18 261 4.9E-40 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 SUPERFAMILY SSF56112 13 261 1.24E-62 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 135 147 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 Gene3D G3DSA:3.30.200.20 7 113 1.2E-16 T 17-03-2017 SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 Gene3D G3DSA:1.10.510.10 114 273 4.6E-39 T 17-03-2017 SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 SMART SM00220 17 269 5.0E-46 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS12780 1972c9b785f99c12b3bd6a1ed79c1e3a 441 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 23 45 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 178 194 7.4E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 194 206 7.4E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 164 178 7.4E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 SUPERFAMILY SSF52172 8 182 3.32E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 Pfam PF00196 Bacterial regulatory proteins, luxR family 163 218 1.2E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 Gene3D G3DSA:1.10.10.10 164 223 4.0E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 SMART SM00421 161 218 3.1E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 Pfam PF00072 Response regulator receiver domain 12 123 3.1E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 SMART SM00448 10 122 6.6E-34 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 Gene3D G3DSA:3.40.50.2300 8 163 2.0E-37 T 17-03-2017 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 ProSitePatterns PS00622 LuxR-type HTH domain signature. 178 205 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18760 6d5082a2c0360162905c017127b7d98b 226 SUPERFAMILY SSF46894 162 223 3.12E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 Gene3D G3DSA:1.10.540.10 30 168 3.0E-27 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 278 436 2.6E-30 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 170 265 8.1E-21 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 Gene3D G3DSA:1.20.140.10 268 440 5.2E-48 T 17-03-2017 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 SUPERFAMILY SSF47203 278 437 1.34E-35 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 61 165 2.9E-19 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 SUPERFAMILY SSF56645 35 288 1.83E-58 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS36860 cb7f0e2e08cca21d4913638b6932ab22 644 Gene3D G3DSA:2.40.110.10 169 267 5.6E-33 T 17-03-2017 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 Gene3D G3DSA:2.60.15.10 4 88 9.0E-25 T 17-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 ProDom PD000944 ATP SYNTHASE ION EPSILON SUBUNIT HYDROLASE CF1 SYNTHESIS CHAIN HYDROGEN 18 90 4.0E-30 T 17-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 TIGRFAM TIGR01216 ATP_synt_epsi: ATP synthase F1, epsilon subunit 5 114 1.5E-25 T 17-03-2017 IPR001469 ATPase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 Hamap MF_00530 ATP synthase epsilon chain [atpC]. 3 120 18.518 T 17-03-2017 IPR001469 ATPase, F1 complex, delta/epsilon subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 Pfam PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain 5 84 6.7E-23 T 17-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 Gene3D G3DSA:1.20.5.440 89 102 4.5E-4 T 17-03-2017 SHXM_RS35265 511972807a33744e1adf09bf4fc92b27 125 SUPERFAMILY SSF51344 5 85 1.16E-20 T 17-03-2017 IPR020546 ATPase, F1 complex, delta/epsilon subunit, N-terminal GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS42175 06a125cb605076e849769630aa724988 364 Gene3D G3DSA:3.90.180.10 1 173 1.2E-48 T 17-03-2017 IPR011032 GroES-like SHXM_RS42175 06a125cb605076e849769630aa724988 364 Pfam PF00107 Zinc-binding dehydrogenase 178 303 3.7E-20 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS42175 06a125cb605076e849769630aa724988 364 SUPERFAMILY SSF50129 1 177 2.99E-45 T 17-03-2017 IPR011032 GroES-like SHXM_RS42175 06a125cb605076e849769630aa724988 364 Gene3D G3DSA:3.40.50.720 174 292 1.7E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42175 06a125cb605076e849769630aa724988 364 SMART SM00829 7 344 1.9E-5 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS42175 06a125cb605076e849769630aa724988 364 SUPERFAMILY SSF51735 141 312 4.72E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42175 06a125cb605076e849769630aa724988 364 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 126 1.3E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS42175 06a125cb605076e849769630aa724988 364 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 60 74 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.47.10 3036 3202 1.6E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.47.10 4353 4519 2.7E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.47.10 1345 1510 2.2E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF51735 2219 2377 4.13E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF51735 2386 2615 2.23E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF51735 5256 5516 7.61E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:1.10.1200.10 5546 5620 2.7E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:1.10.1200.10 3989 4064 4.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:1.10.1200.10 2675 2749 4.2E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:1.10.1200.10 988 1059 2.0E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF51735 761 935 1.82E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5575 5590 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF14765 Polyketide synthase dehydratase 3719 3881 1.2E-12 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF14765 Polyketide synthase dehydratase 1982 2117 4.8E-17 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM01294 3994 4061 3.0E-4 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.50.720 5260 5461 5.7E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2389 2569 1.5E-55 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5260 5442 9.9E-22 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.50.980 222 381 4.9E-35 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF53901 1081 1454 6.37E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.50.720 762 918 1.3E-4 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF47336 2671 2754 5.76E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF47336 987 1098 1.57E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF51735 574 746 8.66E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF55048 1740 1804 3.66E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1083 1332 5.7E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2774 3023 1.9E-86 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4090 4340 2.0E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF47336 5540 5625 1.31E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF52151 3508 3600 8.89E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF52151 3308 3444 8.89E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00455 Putative AMP-binding domain signature. 217 228 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF13193 AMP-binding enzyme C-terminal domain 473 547 1.5E-16 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00501 AMP-binding enzyme 55 464 3.1E-110 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF51735 5039 5246 1.54E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.366.10 4811 4937 4.0E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.366.10 4612 4742 4.0E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF47336 3987 4105 1.44E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.30.70.250 4748 4805 4.2E-5 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.30.70.250 1740 1797 3.8E-9 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.30.70.250 3443 3506 2.5E-7 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2936 2952 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 4622 4924 8.4E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1616 1915 6.1E-107 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3312 3615 7.6E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF08659 KR domain 5260 5440 7.6E-39 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF08659 KR domain 2389 2567 3.8E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.47.10 4092 4352 2.6E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.47.10 1085 1344 6.0E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.47.10 2776 3035 4.4E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00698 Acyl transferase domain 3311 3593 3.2E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00698 Acyl transferase domain 4621 4942 3.5E-80 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00698 Acyl transferase domain 1615 1933 2.9E-73 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4020 4035 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 4253 4269 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00823 Phosphopantetheine attachment site 3993 4065 2.4E-26 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00823 Phosphopantetheine attachment site 987 1059 6.3E-20 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00823 Phosphopantetheine attachment site 5548 5620 3.4E-25 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00823 Phosphopantetheine attachment site 2678 2750 1.1E-24 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF52151 4618 4748 1.26E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF52151 4812 4905 1.26E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00826 1982 2147 2.8E-44 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00826 3683 3836 9.5E-27 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF53901 4086 4464 1.25E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3031 3148 1.9E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 4348 4465 2.1E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1340 1457 5.7E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:2.30.38.10 382 455 1.5E-30 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF55048 4746 4808 3.4E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF55048 3443 3507 2.88E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.50.720 2388 2573 3.0E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00825 Beta-ketoacyl synthase 4092 4518 2.4E-215 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00825 Beta-ketoacyl synthase 2776 3201 1.3E-208 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SMART SM00825 Beta-ketoacyl synthase 1085 1510 7.9E-216 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF52151 1806 1904 3.14E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF52151 1612 1741 3.14E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.366.10 1612 1735 1.6E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.366.10 1804 1916 1.6E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2705 2720 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.50.980 53 221 1.3E-39 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.366.10 3303 3438 1.5E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.40.366.10 3507 3617 1.5E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00550 Phosphopantetheine attachment site 5551 5616 5.4E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00550 Phosphopantetheine attachment site 992 1055 9.5E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00550 Phosphopantetheine attachment site 2680 2746 2.0E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF00550 Phosphopantetheine attachment site 3996 4061 1.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF53901 2771 3145 2.12E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Gene3D G3DSA:3.30.300.30 459 555 1.1E-25 T 17-03-2017 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1245 1261 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 4468 4571 1.3E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3151 3273 1.2E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1460 1547 6.6E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39600 be0351456cdfdf745340f054e43189c3 5707 SUPERFAMILY SSF56801 53 558 3.53E-154 T 17-03-2017 SHXM_RS05795 f3e91726db7296d94c367fd744b019ac 137 SUPERFAMILY SSF160719 34 131 2.62E-21 T 17-03-2017 SHXM_RS05795 f3e91726db7296d94c367fd744b019ac 137 Pfam PF04965 Gene 25-like lysozyme 37 123 9.3E-18 T 17-03-2017 IPR007048 GpW/Gp25/anti-adapter protein IraD SHXM_RS05795 f3e91726db7296d94c367fd744b019ac 137 Gene3D G3DSA:3.10.450.40 14 130 1.6E-31 T 17-03-2017 SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 Pfam PF00486 Transcriptional regulatory protein, C terminal 145 217 7.4E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 SUPERFAMILY SSF52172 2 172 1.29E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 SMART SM00448 1 112 6.1E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 Gene3D G3DSA:3.40.50.2300 2 119 2.5E-32 T 17-03-2017 SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 SMART SM00862 145 217 4.1E-22 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 Pfam PF00072 Response regulator receiver domain 3 113 2.4E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37600 1b1b1acf8944ff409618a0bf37e01c1e 217 Gene3D G3DSA:1.10.10.10 125 217 6.3E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38795 f1e0512d386141d6dbf78d22a4bbe218 132 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 11 92 7.1E-11 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS38795 f1e0512d386141d6dbf78d22a4bbe218 132 SUPERFAMILY SSF50475 4 120 9.35E-19 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS38795 f1e0512d386141d6dbf78d22a4bbe218 132 Gene3D G3DSA:2.30.110.10 1 122 8.8E-18 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS38795 f1e0512d386141d6dbf78d22a4bbe218 132 TIGRFAM TIGR04023 PPOX_MSMEG_5819: PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family 4 120 1.3E-39 T 17-03-2017 IPR024031 PPOX class F420-dependent enzyme, MSMEG_5819/OxyR family SHXM_RS14880 707c230f90520ca5441d0da285aeab61 123 Gene3D G3DSA:1.10.10.10 13 76 1.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14880 707c230f90520ca5441d0da285aeab61 123 SUPERFAMILY SSF46785 3 122 1.21E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14880 707c230f90520ca5441d0da285aeab61 123 Gene3D G3DSA:1.10.287.100 77 122 2.7E-14 T 17-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 SHXM_RS14880 707c230f90520ca5441d0da285aeab61 123 Pfam PF01047 MarR family 13 71 5.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS14880 707c230f90520ca5441d0da285aeab61 123 SMART SM00347 6 107 8.6E-16 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS45750 c2f800fefd561ba40a4890cb009dd8ec 367 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 7 120 5.5E-21 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS45750 c2f800fefd561ba40a4890cb009dd8ec 367 Gene3D G3DSA:3.30.360.10 144 350 1.5E-22 T 17-03-2017 SHXM_RS45750 c2f800fefd561ba40a4890cb009dd8ec 367 Gene3D G3DSA:3.40.50.720 2 143 4.0E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45750 c2f800fefd561ba40a4890cb009dd8ec 367 SUPERFAMILY SSF55347 131 293 8.34E-27 T 17-03-2017 SHXM_RS45750 c2f800fefd561ba40a4890cb009dd8ec 367 SUPERFAMILY SSF51735 3 153 4.69E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 Gene3D G3DSA:2.30.38.10 297 370 1.7E-13 T 17-03-2017 SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 Gene3D G3DSA:3.30.300.30 372 468 9.3E-11 T 17-03-2017 SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 Gene3D G3DSA:3.40.50.980 141 290 1.2E-27 T 17-03-2017 SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 Gene3D G3DSA:3.40.50.980 12 140 1.2E-16 T 17-03-2017 SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 ProSitePatterns PS00455 Putative AMP-binding domain signature. 134 145 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 SUPERFAMILY SSF56801 9 469 7.98E-83 T 17-03-2017 SHXM_RS22115 963862440e0d933bd929addf94db24f7 469 Pfam PF00501 AMP-binding enzyme 12 370 1.1E-56 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 SUPERFAMILY SSF48113 694 916 1.13E-82 T 17-03-2017 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 SUPERFAMILY SSF48113 506 666 1.13E-82 T 17-03-2017 IPR010255 Haem peroxidase GO:0004601|GO:0006979|GO:0020037|GO:0055114 SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 PRINTS PR00457 Animal haem peroxidase signature 601 621 1.9E-6 T 17-03-2017 IPR019791 Haem peroxidase, animal SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 PRINTS PR00457 Animal haem peroxidase signature 626 652 1.9E-6 T 17-03-2017 IPR019791 Haem peroxidase, animal SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 PRINTS PR00457 Animal haem peroxidase signature 826 846 1.9E-6 T 17-03-2017 IPR019791 Haem peroxidase, animal SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 SUPERFAMILY SSF56634 98 377 9.29E-44 T 17-03-2017 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 Gene3D G3DSA:1.10.640.10 473 565 3.7E-4 T 17-03-2017 IPR019791 Haem peroxidase, animal SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 Gene3D G3DSA:1.10.640.10 591 916 1.6E-59 T 17-03-2017 IPR019791 Haem peroxidase, animal SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 Gene3D G3DSA:2.40.180.10 104 375 5.7E-35 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS07160 b6057c240d478b9fb8ad5b2e8d550075 937 Pfam PF03098 Animal haem peroxidase 590 916 1.1E-59 T 17-03-2017 IPR019791 Haem peroxidase, animal SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 SUPERFAMILY SSF55781 71 250 1.96E-35 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 SUPERFAMILY SSF46785 5 77 4.32E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 SMART SM00346 5 95 7.7E-36 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 Pfam PF01614 Bacterial transcriptional regulator 123 247 3.7E-31 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 Gene3D G3DSA:1.10.10.10 4 74 6.4E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 Gene3D G3DSA:3.30.450.40 75 250 3.9E-42 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS15985 715f758dab06e1ed24de9cc8748eef5c 254 Pfam PF09339 IclR helix-turn-helix domain 7 57 7.8E-17 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 SMART SM00304 196 248 1.6E-15 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 SMART SM00387 363 475 5.9E-31 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 Gene3D G3DSA:1.10.287.130 249 309 4.2E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 SMART SM00388 256 323 9.5E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 PRINTS PR00344 Bacterial sensor protein C-terminal signature 459 472 8.4E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 PRINTS PR00344 Bacterial sensor protein C-terminal signature 432 450 8.4E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 PRINTS PR00344 Bacterial sensor protein C-terminal signature 398 412 8.4E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 PRINTS PR00344 Bacterial sensor protein C-terminal signature 416 426 8.4E-15 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 SUPERFAMILY SSF158472 198 245 3.92E-9 T 17-03-2017 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 SUPERFAMILY SSF55874 312 476 4.71E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 Pfam PF00672 HAMP domain 183 245 2.6E-16 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 SUPERFAMILY SSF47384 241 323 4.9E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 Gene3D G3DSA:3.30.565.10 310 476 1.5E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 364 473 6.2E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11855 7c920ead60e00912d3006fb1c9bb62dc 495 Pfam PF00512 His Kinase A (phospho-acceptor) domain 258 323 4.1E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45440 e86f0a54e8370d2bc1718c79ef4168c7 169 Pfam PF04978 Protein of unknown function (DUF664) 28 165 7.5E-39 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS45440 e86f0a54e8370d2bc1718c79ef4168c7 169 Gene3D G3DSA:1.20.120.450 11 169 3.5E-43 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS45440 e86f0a54e8370d2bc1718c79ef4168c7 169 SUPERFAMILY SSF109854 13 164 8.24E-40 T 17-03-2017 SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 SUPERFAMILY SSF53474 70 222 2.1E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 SUPERFAMILY SSF53474 291 373 2.1E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 Pfam PF03583 Secretory lipase 118 382 7.3E-55 T 17-03-2017 IPR005152 Lipase, secreted GO:0004806|GO:0016042 KEGG: 00561+3.1.1.3|MetaCyc: PWY-6857 SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 PIRSF PIRSF029171 1 385 1.8E-69 T 17-03-2017 IPR005152 Lipase, secreted GO:0004806|GO:0016042 KEGG: 00561+3.1.1.3|MetaCyc: PWY-6857 SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 Gene3D G3DSA:3.40.50.1820 270 271 8.8E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 Gene3D G3DSA:3.40.50.1820 306 357 8.8E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30690 a18eec26f7097cb1f5736e536afd8ce4 387 Gene3D G3DSA:3.40.50.1820 75 226 8.8E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 Pfam PF01174 SNO glutamine amidotransferase family 22 206 3.5E-59 T 17-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 ProSitePatterns PS01236 PdxT/SNO family family signature. 57 67 - T 17-03-2017 IPR021196 PdxT/SNO family, conserved site KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 TIGRFAM TIGR03800 PLP_synth_Pdx2: pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2 20 204 1.2E-79 T 17-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 SUPERFAMILY SSF52317 19 207 2.36E-53 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 Hamap MF_01615 Pyridoxal 5'-phosphate synthase subunit PdxT [pdxT]. 20 205 37.894 T 17-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 Gene3D G3DSA:3.40.50.880 18 208 2.3E-79 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS12560 05801511d43ed51a9cc945c0b5c0d2d1 209 PIRSF PIRSF005639 14 209 2.5E-74 T 17-03-2017 IPR002161 Pyridoxal 5'-phosphate synthase subunit PdxT/SNO GO:0004359|GO:0042819|GO:0042823 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 Gene3D G3DSA:3.40.47.10 4 124 2.3E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 Gene3D G3DSA:3.40.47.10 196 268 2.3E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 PIRSF PIRSF000429 1 385 3.2E-121 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 Pfam PF02803 Thiolase, C-terminal domain 263 384 9.9E-44 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 Gene3D G3DSA:3.40.47.10 269 384 3.6E-57 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 Gene3D G3DSA:3.40.47.10 161 195 3.6E-57 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 SUPERFAMILY SSF53901 4 262 1.17E-69 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 SUPERFAMILY SSF53901 263 384 1.47E-41 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 ProSitePatterns PS00737 Thiolases signature 2. 331 347 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 Pfam PF00108 Thiolase, N-terminal domain 5 254 1.5E-56 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS47120 3b821be57e2617869deb397ed641ecb5 385 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 6 383 2.5E-125 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS46170 e3a3643973f892444a9c15a5eb670962 648 Gene3D G3DSA:3.20.20.80 30 171 3.2E-31 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS46170 e3a3643973f892444a9c15a5eb670962 648 Gene3D G3DSA:3.20.20.80 203 436 3.2E-31 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS46170 e3a3643973f892444a9c15a5eb670962 648 SUPERFAMILY SSF51445 52 176 6.18E-31 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS46170 e3a3643973f892444a9c15a5eb670962 648 SUPERFAMILY SSF51445 234 424 6.18E-31 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS46170 e3a3643973f892444a9c15a5eb670962 648 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 99 419 1.8E-13 T 17-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 SUPERFAMILY SSF53155 4 83 1.2E-18 T 17-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 Pfam PF02870 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain 5 74 1.4E-7 T 17-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 Hamap MF_00772 Methylated-DNA--protein-cysteine methyltransferase [ogt]. 2 160 36.976 T 17-03-2017 IPR023546 Methylated-DNA--protein-cysteine methyltransferase GO:0003824|GO:0006281 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 SUPERFAMILY SSF46767 77 158 9.29E-33 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 128 134 - T 17-03-2017 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 Gene3D G3DSA:1.10.10.10 77 158 2.0E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 78 157 2.0E-34 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS14800 6abd2c1f7e38b0fccdd4d570ec0ccdc3 166 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 79 157 1.1E-32 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS35980 c1d77dd6c82271dd05cf6589dc77b695 334 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 33 69 5.1E-12 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS35980 c1d77dd6c82271dd05cf6589dc77b695 334 Gene3D G3DSA:1.10.3720.10 113 330 7.5E-34 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35980 c1d77dd6c82271dd05cf6589dc77b695 334 SUPERFAMILY SSF161098 117 315 8.5E-31 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35980 c1d77dd6c82271dd05cf6589dc77b695 334 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 140 331 3.5E-29 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24965 fc9d0129e16873a47bcff381df0f4163 312 Pfam PF01636 Phosphotransferase enzyme family 36 259 7.5E-36 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS24965 fc9d0129e16873a47bcff381df0f4163 312 SUPERFAMILY SSF56112 20 267 6.29E-48 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS24965 fc9d0129e16873a47bcff381df0f4163 312 Gene3D G3DSA:3.90.1200.10 107 267 1.7E-35 T 17-03-2017 SHXM_RS44225 66a713c22cc7f3c72892d121d0f07a05 455 Pfam PF00083 Sugar (and other) transporter 229 436 2.8E-12 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS44225 66a713c22cc7f3c72892d121d0f07a05 455 Pfam PF00083 Sugar (and other) transporter 30 227 7.0E-23 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS44225 66a713c22cc7f3c72892d121d0f07a05 455 ProSitePatterns PS00217 Sugar transport proteins signature 2. 135 160 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS44225 66a713c22cc7f3c72892d121d0f07a05 455 Gene3D G3DSA:1.20.1250.20 242 428 1.5E-24 T 17-03-2017 SHXM_RS44225 66a713c22cc7f3c72892d121d0f07a05 455 Gene3D G3DSA:1.20.1250.20 24 224 3.3E-24 T 17-03-2017 SHXM_RS44225 66a713c22cc7f3c72892d121d0f07a05 455 SUPERFAMILY SSF103473 22 433 5.49E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 Gene3D G3DSA:2.60.120.10 9 135 5.2E-20 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 SUPERFAMILY SSF46785 146 224 6.76E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 SMART SM00419 168 216 1.5E-9 T 17-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 Pfam PF00027 Cyclic nucleotide-binding domain 29 114 1.2E-12 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 Pfam PF13545 Crp-like helix-turn-helix domain 148 221 1.7E-14 T 17-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 SMART SM00100 10 128 5.3E-12 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 Gene3D G3DSA:1.10.10.10 146 225 4.8E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37960 e7356372937e9585e07b146157a4c9fd 243 SUPERFAMILY SSF51206 8 134 1.57E-21 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 Pfam PF12833 Helix-turn-helix domain 81 159 5.2E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 Gene3D G3DSA:3.40.50.880 12 64 2.4E-5 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 Gene3D G3DSA:1.10.10.60 115 161 1.3E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 Gene3D G3DSA:1.10.10.60 65 114 1.6E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 SUPERFAMILY SSF46689 58 106 5.55E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 SUPERFAMILY SSF46689 112 159 3.63E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49065 344017aa74e1d379d2c04b7d36cfbd9f 177 SMART SM00342 75 158 2.0E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS44925 a418ea173db764755f311ddbcafd765d 122 Pfam PF01471 Putative peptidoglycan binding domain 58 118 1.7E-10 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS44925 a418ea173db764755f311ddbcafd765d 122 SUPERFAMILY SSF47090 48 118 2.43E-14 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS44925 a418ea173db764755f311ddbcafd765d 122 Gene3D G3DSA:1.10.101.10 48 119 2.0E-16 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS11815 a355d9d6879aeba123d283b751470d72 240 Gene3D G3DSA:1.10.10.60 21 88 1.7E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11815 a355d9d6879aeba123d283b751470d72 240 Pfam PF00440 Bacterial regulatory proteins, tetR family 37 78 2.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11815 a355d9d6879aeba123d283b751470d72 240 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 93 240 1.6E-14 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS11815 a355d9d6879aeba123d283b751470d72 240 SUPERFAMILY SSF48498 100 240 3.67E-25 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11815 a355d9d6879aeba123d283b751470d72 240 SUPERFAMILY SSF46689 24 90 1.28E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11815 a355d9d6879aeba123d283b751470d72 240 Gene3D G3DSA:1.10.357.10 89 240 2.4E-33 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 Gene3D G3DSA:3.40.50.1820 3 285 2.5E-64 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 SUPERFAMILY SSF53474 3 284 1.31E-67 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 Pfam PF00561 alpha/beta hydrolase fold 27 145 5.9E-21 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 PRINTS PR00412 Epoxide hydrolase signature 33 51 5.7E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 PRINTS PR00412 Epoxide hydrolase signature 113 126 5.7E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 PRINTS PR00412 Epoxide hydrolase signature 228 244 5.7E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 PRINTS PR00412 Epoxide hydrolase signature 261 283 5.7E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01870 f2c934c031d589a1ff29f85331a7d18d 291 PRINTS PR00412 Epoxide hydrolase signature 99 112 5.7E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 Hamap MF_00942 Endonuclease III [nth]. 35 248 38.33 T 17-03-2017 IPR005759 Endonuclease III GO:0003906|GO:0006284 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 SMART SM00478 77 224 1.3E-58 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 Pfam PF10576 Iron-sulfur binding domain of endonuclease III 226 242 3.9E-5 T 17-03-2017 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 SMART SM00525 225 245 1.6E-6 T 17-03-2017 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 TIGRFAM TIGR01083 nth: endonuclease III 44 233 5.6E-76 T 17-03-2017 IPR005759 Endonuclease III GO:0003906|GO:0006284 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 Gene3D G3DSA:1.10.1670.10 162 247 3.9E-34 T 17-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 SUPERFAMILY SSF48150 44 254 5.81E-69 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 Pfam PF00633 Helix-hairpin-helix motif 138 165 1.1E-7 T 17-03-2017 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 ProSitePatterns PS01155 Endonuclease III family signature. 141 170 - T 17-03-2017 IPR004036 Endonuclease III-like, conserved site-2 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 ProSitePatterns PS00764 Endonuclease III iron-sulfur binding region signature. 226 242 - T 17-03-2017 IPR004035 Endonuclease III, iron-sulphur binding site Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 Gene3D G3DSA:1.10.340.30 62 161 4.0E-36 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS26995 7da80ec4613e7b6a9fba50c2edd281fd 289 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 73 207 8.0E-21 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS19470 9038946c0c4fe0693facd08de9e2fd51 437 SUPERFAMILY SSF103473 29 418 9.29E-43 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19470 9038946c0c4fe0693facd08de9e2fd51 437 Pfam PF05977 Transmembrane secretion effector 22 435 1.3E-33 T 17-03-2017 IPR010290 Transmembrane secretion effector SHXM_RS19470 9038946c0c4fe0693facd08de9e2fd51 437 Gene3D G3DSA:1.20.1250.20 248 412 3.1E-14 T 17-03-2017 SHXM_RS19470 9038946c0c4fe0693facd08de9e2fd51 437 Gene3D G3DSA:1.20.1250.20 29 216 4.3E-18 T 17-03-2017 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 SMART SM00345 29 85 1.1E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 60 76 1.3E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 46 60 1.3E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 Pfam PF07702 UTRA domain 106 243 1.6E-32 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 Gene3D G3DSA:3.40.1410.10 85 249 4.8E-44 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 SMART SM00866 105 244 2.3E-32 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 Gene3D G3DSA:1.10.10.10 20 84 2.7E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 Pfam PF00392 Bacterial regulatory proteins, gntR family 28 85 3.5E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 SUPERFAMILY SSF64288 77 249 9.11E-45 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS42450 d90e0ffc6357ebb4af4a4625c414e327 251 SUPERFAMILY SSF46785 20 94 1.76E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 ProSitePatterns PS00164 Enolase signature. 332 345 - T 17-03-2017 IPR020809 Enolase, conserved site KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PRINTS PR00148 Enolase signature 361 378 2.8E-47 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PRINTS PR00148 Enolase signature 309 320 2.8E-47 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PRINTS PR00148 Enolase signature 332 346 2.8E-47 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PRINTS PR00148 Enolase signature 107 123 2.8E-47 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PRINTS PR00148 Enolase signature 161 174 2.8E-47 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PRINTS PR00148 Enolase signature 37 51 2.8E-47 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 Hamap MF_00318 Enolase [eno]. 2 409 45.26 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 TIGRFAM TIGR01060 eno: phosphopyruvate hydratase 4 423 6.8E-207 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 Pfam PF03952 Enolase, N-terminal domain 4 134 1.8E-55 T 17-03-2017 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 SMART SM01193 4 134 6.8E-87 T 17-03-2017 IPR020811 Enolase, N-terminal KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 Gene3D G3DSA:3.30.390.10 4 125 1.2E-52 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 SUPERFAMILY SSF54826 4 138 1.2E-51 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 Gene3D G3DSA:3.20.20.120 128 421 1.5E-137 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 PIRSF PIRSF001400 2 422 2.1E-189 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 SUPERFAMILY SSF51604 138 422 2.18E-132 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 Pfam PF00113 Enolase, C-terminal TIM barrel domain 140 420 1.2E-134 T 17-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS24550 b4d204a865dfd1eee98e5a4cd67099fa 426 SMART SM01192 139 423 5.2E-228 T 17-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS25330 5e9fee93ae009d441fc0a5c05ea683d8 136 Gene3D G3DSA:3.40.50.280 6 131 9.1E-56 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS25330 5e9fee93ae009d441fc0a5c05ea683d8 136 Pfam PF02310 B12 binding domain 7 120 8.4E-25 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS25330 5e9fee93ae009d441fc0a5c05ea683d8 136 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 7 132 1.8E-49 T 17-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS25330 5e9fee93ae009d441fc0a5c05ea683d8 136 SUPERFAMILY SSF52242 5 131 3.14E-50 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 Pfam PF00067 Cytochrome P450 83 400 1.1E-31 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00385 P450 superfamily signature 349 358 2.4E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00385 P450 superfamily signature 282 293 2.4E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00385 P450 superfamily signature 247 264 2.4E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00385 P450 superfamily signature 358 369 2.4E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 SUPERFAMILY SSF48264 9 407 1.96E-90 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 Gene3D G3DSA:1.10.630.10 6 408 8.5E-119 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 351 360 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 200 222 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 358 369 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 282 293 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 152 167 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 328 343 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 300 327 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 349 358 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 135 151 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30555 869674213ef9dbed953fcaf26fe789aa 412 PRINTS PR00359 B-class P450 signature 85 96 2.5E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03760 170739bce2fdd102aa9dce8dbed1c620 346 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 206 215 - T 17-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SHXM_RS03760 170739bce2fdd102aa9dce8dbed1c620 346 SUPERFAMILY SSF53383 12 330 3.52E-66 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS03760 170739bce2fdd102aa9dce8dbed1c620 346 Gene3D G3DSA:3.90.1150.10 248 336 9.9E-9 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS03760 170739bce2fdd102aa9dce8dbed1c620 346 Gene3D G3DSA:3.40.640.10 31 247 2.3E-55 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS03760 170739bce2fdd102aa9dce8dbed1c620 346 Pfam PF00155 Aminotransferase class I and II 27 326 4.7E-42 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 Pfam PF07690 Major Facilitator Superfamily 34 392 1.7E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 ProSitePatterns PS00216 Sugar transport proteins signature 1. 87 103 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 ProSitePatterns PS00217 Sugar transport proteins signature 2. 137 162 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 ProSitePatterns PS00216 Sugar transport proteins signature 1. 307 324 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 Gene3D G3DSA:1.20.1250.20 264 438 3.5E-14 T 17-03-2017 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 Gene3D G3DSA:1.20.1250.20 24 229 2.2E-25 T 17-03-2017 SHXM_RS15565 585b54f27898ac8e2aee269fd0c09e8c 473 SUPERFAMILY SSF103473 16 434 1.7E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 Pfam PF01120 Alpha-L-fucosidase 3 311 6.6E-88 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 SUPERFAMILY SSF51445 4 316 2.74E-94 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 PRINTS PR00741 Glycosyl hydrolase family 29 signature 266 287 1.2E-17 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 PRINTS PR00741 Glycosyl hydrolase family 29 signature 116 135 1.2E-17 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 PRINTS PR00741 Glycosyl hydrolase family 29 signature 70 86 1.2E-17 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 PRINTS PR00741 Glycosyl hydrolase family 29 signature 299 321 1.2E-17 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 PIRSF PIRSF001092 1 421 1.2E-128 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 SMART SM00812 2 357 1.6E-142 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS47000 c1530153b77808fb4ed25a91680fdd1a 422 Gene3D G3DSA:3.20.20.80 6 316 8.8E-98 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 Gene3D G3DSA:3.40.50.880 289 541 7.5E-85 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 SUPERFAMILY SSF52317 289 541 3.21E-68 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 Pfam PF06418 CTP synthase N-terminus 4 267 3.4E-122 T 17-03-2017 IPR017456 CTP synthase, N-terminal GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 Hamap MF_01227 CTP synthase [pyrG]. 3 541 50.252 T 17-03-2017 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 TIGRFAM TIGR00337 PyrG: CTP synthase 2 536 4.6E-228 T 17-03-2017 IPR004468 CTP synthase GO:0003883|GO:0006221 KEGG: 00240+6.3.4.2|MetaCyc: PWY-7176|MetaCyc: PWY-7177|MetaCyc: PWY-7185|Reactome: R-HSA-499943 SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 SUPERFAMILY SSF52540 3 267 7.27E-118 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 Gene3D G3DSA:3.40.50.300 1 285 1.2E-130 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17100 cd21a4b05c299cecd45ef7f58d611f58 551 Pfam PF00117 Glutamine amidotransferase class-I 302 536 2.1E-47 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 SMART SM00895 115 234 2.5E-12 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 SUPERFAMILY SSF48008 112 237 7.06E-19 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 Pfam PF07729 FCD domain 118 233 1.8E-16 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 SMART SM00345 30 91 3.1E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 SUPERFAMILY SSF46785 21 106 4.73E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 Pfam PF00392 Bacterial regulatory proteins, gntR family 28 85 2.1E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 Gene3D G3DSA:1.10.10.10 29 98 1.8E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45445 1abee5578aa8e5b1cb83a347ff754187 253 Gene3D G3DSA:1.20.120.530 111 236 5.0E-20 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS47495 2d0ddf59030ec0c906bb75cebf2bb994 160 Gene3D G3DSA:1.10.287.100 120 153 6.6E-7 T 17-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 SHXM_RS47495 2d0ddf59030ec0c906bb75cebf2bb994 160 Gene3D G3DSA:1.10.10.10 42 104 1.4E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47495 2d0ddf59030ec0c906bb75cebf2bb994 160 Pfam PF12802 MarR family 42 99 3.2E-11 T 17-03-2017 SHXM_RS47495 2d0ddf59030ec0c906bb75cebf2bb994 160 SMART SM00347 36 136 6.7E-4 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47495 2d0ddf59030ec0c906bb75cebf2bb994 160 SUPERFAMILY SSF46785 19 152 3.37E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02110 ef9ef7602c44262b02796da2435ccac4 158 SUPERFAMILY SSF52242 14 143 3.61E-18 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS02110 ef9ef7602c44262b02796da2435ccac4 158 Gene3D G3DSA:3.40.50.280 15 144 6.4E-17 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS02110 ef9ef7602c44262b02796da2435ccac4 158 Pfam PF02310 B12 binding domain 16 105 1.4E-10 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 3.2E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 Gene3D G3DSA:1.10.10.10 3 86 3.2E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 3.3E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 3.3E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 3.3E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 Gene3D G3DSA:3.40.190.10 89 185 5.9E-25 T 17-03-2017 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 Pfam PF03466 LysR substrate binding domain 90 294 1.6E-39 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 Gene3D G3DSA:3.40.190.10 186 264 9.0E-20 T 17-03-2017 SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 SUPERFAMILY SSF46785 2 112 7.39E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23605 60f968f8c8b5102244bd13a98e3276b1 301 SUPERFAMILY SSF53850 91 297 1.19E-35 T 17-03-2017 SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 251 336 2.1E-18 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 ProSitePatterns PS00211 ABC transporters family signature. 174 188 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 253 318 2.6E-15 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 Gene3D G3DSA:3.40.50.300 24 275 7.8E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 Pfam PF00005 ABC transporter 42 201 3.1E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 SUPERFAMILY SSF52540 28 272 4.31E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02380 6d3965e47546bae230176ca4f3c00b1e 358 SMART SM00382 50 259 3.3E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 SUPERFAMILY SSF53901 274 400 5.32E-35 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 Gene3D G3DSA:3.40.47.10 203 279 4.0E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 Gene3D G3DSA:3.40.47.10 6 128 4.0E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 ProSitePatterns PS00737 Thiolases signature 2. 347 363 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 ProSitePatterns PS00098 Thiolases acyl-enzyme intermediate signature. 89 107 - T 17-03-2017 IPR020615 Thiolase, acyl-enzyme intermediate active site GO:0008152|GO:0016747 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 Pfam PF00108 Thiolase, N-terminal domain 7 266 2.0E-71 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 Gene3D G3DSA:3.40.47.10 163 202 1.0E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 Gene3D G3DSA:3.40.47.10 280 399 1.0E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 SUPERFAMILY SSF53901 6 272 6.48E-77 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 9 399 8.9E-132 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 ProSitePatterns PS00099 Thiolases active site. 382 395 - T 17-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 Pfam PF02803 Thiolase, C-terminal domain 274 400 1.3E-36 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS20835 d4cd1e43a9ade26c66c2b4b602cb345e 400 PIRSF PIRSF000429 1 400 4.5E-126 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 SMART SM01086 776 865 4.8E-33 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 SMART SM00382 203 348 2.9E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 SMART SM00382 605 750 3.0E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Gene3D G3DSA:3.40.50.300 560 787 1.5E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 SUPERFAMILY SSF52540 164 553 1.95E-93 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 SUPERFAMILY SSF81923 4 160 3.04E-42 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Gene3D G3DSA:1.10.8.60 788 869 1.3E-29 T 17-03-2017 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 208 340 3.5E-11 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 639 657 - T 17-03-2017 IPR028299 ClpA/B, conserved site 2 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 SUPERFAMILY SSF52540 554 864 5.17E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Pfam PF07724 AAA domain (Cdc48 subfamily) 604 770 4.9E-54 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Gene3D G3DSA:1.10.1780.10 1 153 5.2E-46 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Gene3D G3DSA:1.10.8.60 348 432 5.3E-35 T 17-03-2017 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 654 672 1.3E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 716 730 1.3E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 609 627 1.3E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 683 701 1.3E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Gene3D G3DSA:3.40.50.300 164 347 1.2E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 TIGRFAM TIGR03346 chaperone_ClpB: ATP-dependent chaperone protein ClpB 6 865 0.0 T 17-03-2017 IPR017730 Chaperonin ClpB GO:0005737|GO:0009408|GO:0016485 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 776 856 2.8E-23 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 97 150 3.3E-12 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 17 67 9.6E-12 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS19620 0b11f6703aa68b8d0b1c1886f512b0d1 880 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 299 311 - T 17-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 TIGRFAM TIGR00082 rbfA: ribosome-binding factor A 1 110 9.8E-22 T 17-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 Hamap MF_00003 Ribosome-binding factor A [rbfA]. 2 116 19.549 T 17-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 SUPERFAMILY SSF89919 2 112 9.03E-31 T 17-03-2017 IPR023799 Ribosome-binding factor A domain SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 Pfam PF02033 Ribosome-binding factor A 6 109 1.6E-24 T 17-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 ProSitePatterns PS01319 Ribosome-binding factor A signature. 75 96 - T 17-03-2017 IPR020053 Ribosome-binding factor A, conserved site GO:0006364 SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 ProDom PD007327 FACTOR A RIBOSOME-BINDING PROCESSING RRNA 3D-STRUCTURE RIBOSOMAL-BINDING PRECURSOR A RBFA 9 96 8.0E-26 T 17-03-2017 IPR000238 Ribosome-binding factor A GO:0006364 SHXM_RS36935 1f47afb53aec7c0d341479c9e6c074b7 178 Gene3D G3DSA:3.30.300.20 4 117 4.8E-36 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS11400 9196b57e7064917c6267b13984e60203 386 SUPERFAMILY SSF51658 25 359 3.18E-96 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS11400 9196b57e7064917c6267b13984e60203 386 ProDom PD042532 ISOMERASE L-RHAMNOSE METAL-BINDING METABOLISM RHAMNOSE MANGANESE ENZYME KINASE 3D-STRUCTURE RHAA/RHAB 105 276 8.0E-6 T 17-03-2017 SHXM_RS11400 9196b57e7064917c6267b13984e60203 386 Gene3D G3DSA:3.20.20.150 16 373 4.9E-91 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS11400 9196b57e7064917c6267b13984e60203 386 TIGRFAM TIGR02635 RhaI_grampos: L-rhamnose isomerase 6 376 7.9E-200 T 17-03-2017 IPR013457 Rhamnose isomerase-related SHXM_RS12045 e4127c080e75059360d0e591fb8cb3dd 418 Pfam PF12844 Helix-turn-helix domain 12 68 1.3E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS12045 e4127c080e75059360d0e591fb8cb3dd 418 SUPERFAMILY SSF48452 288 399 6.54E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12045 e4127c080e75059360d0e591fb8cb3dd 418 Gene3D G3DSA:1.10.260.40 11 77 3.3E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12045 e4127c080e75059360d0e591fb8cb3dd 418 SMART SM00530 14 68 6.9E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS12045 e4127c080e75059360d0e591fb8cb3dd 418 Gene3D G3DSA:1.25.40.10 96 399 1.9E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12045 e4127c080e75059360d0e591fb8cb3dd 418 SUPERFAMILY SSF47413 8 69 1.91E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 Gene3D G3DSA:3.30.70.260 20 98 1.1E-16 T 17-03-2017 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 SUPERFAMILY SSF56784 192 398 3.8E-48 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 193 363 2.2E-29 T 17-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 SUPERFAMILY SSF55021 21 92 4.01E-10 T 17-03-2017 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 Gene3D G3DSA:1.10.150.210 203 254 1.2E-24 T 17-03-2017 IPR023190 Phosphoserine phosphatase, domain 2 GO:0004647|GO:0006564 KEGG: 00260+3.1.3.3|KEGG: 00680+3.1.3.3|Reactome: R-HSA-977347 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 Pfam PF13740 ACT domain 20 93 9.6E-18 T 17-03-2017 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 Gene3D G3DSA:3.40.50.1000 255 383 3.1E-45 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 Pfam PF12710 haloacid dehalogenase-like hydrolase 194 361 1.1E-23 T 17-03-2017 SHXM_RS17275 070c2d2a5aa1fdea216f571258dc1aa4 411 TIGRFAM TIGR00338 serB: phosphoserine phosphatase SerB 185 396 2.4E-76 T 17-03-2017 SHXM_RS20920 aba7f2228d17abbff65085a1403f01a7 367 SMART SM00418 266 337 3.9E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS20920 aba7f2228d17abbff65085a1403f01a7 367 SUPERFAMILY SSF46785 266 337 2.58E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20920 aba7f2228d17abbff65085a1403f01a7 367 Pfam PF12840 Helix-turn-helix domain 275 322 6.1E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20920 aba7f2228d17abbff65085a1403f01a7 367 Gene3D G3DSA:1.10.10.10 280 335 1.0E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15405 02d6001778699ea68d875758913c370f 623 Pfam PF00931 NB-ARC domain 288 484 7.4E-14 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 PRINTS PR00364 Disease resistance protein signature 307 322 4.5E-13 T 17-03-2017 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 PRINTS PR00364 Disease resistance protein signature 467 481 4.5E-13 T 17-03-2017 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 PRINTS PR00364 Disease resistance protein signature 382 396 4.5E-13 T 17-03-2017 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 Gene3D G3DSA:3.40.50.300 287 398 1.8E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15405 02d6001778699ea68d875758913c370f 623 SUPERFAMILY SSF46894 9 97 1.81E-11 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 SUPERFAMILY SSF48452 99 266 7.51E-34 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 SUPERFAMILY SSF52540 274 528 4.66E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15405 02d6001778699ea68d875758913c370f 623 Gene3D G3DSA:1.10.10.10 28 98 1.3E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15405 02d6001778699ea68d875758913c370f 623 SMART SM00862 19 97 1.2E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS15405 02d6001778699ea68d875758913c370f 623 Pfam PF03704 Bacterial transcriptional activator domain 104 248 1.0E-37 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS15405 02d6001778699ea68d875758913c370f 623 SMART SM01043 104 248 1.5E-49 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS15405 02d6001778699ea68d875758913c370f 623 Pfam PF00486 Transcriptional regulatory protein, C terminal 33 97 5.8E-7 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS06520 a9d42af4001f0eff138fcc7dd8f356ae 460 SUPERFAMILY SSF161098 255 433 2.4E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06520 a9d42af4001f0eff138fcc7dd8f356ae 460 Gene3D G3DSA:1.10.3720.10 253 438 9.9E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06520 a9d42af4001f0eff138fcc7dd8f356ae 460 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 19 178 1.1E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06520 a9d42af4001f0eff138fcc7dd8f356ae 460 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 276 435 1.5E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 Gene3D G3DSA:3.40.50.1220 188 341 5.1E-36 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 SUPERFAMILY SSF52518 359 548 5.7E-55 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 Gene3D G3DSA:3.40.50.970 357 551 7.7E-54 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 193 318 1.7E-27 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 Gene3D G3DSA:3.40.50.970 2 173 1.4E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 382 527 3.5E-37 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 5 171 5.4E-42 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 SUPERFAMILY SSF52467 184 346 5.78E-38 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14995 d9d77e1523595e7bbf60e22feba7844c 579 SUPERFAMILY SSF52518 2 172 3.53E-42 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 SUPERFAMILY SSF50621 242 378 2.34E-46 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 282 297 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 127 139 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 303 320 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 164 175 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 207 234 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 358 371 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 265 280 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 30 46 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 PRINTS PR00992 Alanine racemase signature 66 84 4.5E-57 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 Gene3D G3DSA:2.40.37.10 228 378 3.2E-57 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 ProSitePatterns PS00395 Alanine racemase pyridoxal-phosphate attachment site. 36 45 - T 17-03-2017 IPR020622 Alanine racemase, pyridoxal-phosphate attachment site KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 Pfam PF00842 Alanine racemase, C-terminal domain 249 375 4.8E-38 T 17-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 Gene3D G3DSA:3.20.20.10 14 227 4.7E-70 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 Hamap MF_01201 Alanine racemase. 5 376 31.639 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 SUPERFAMILY SSF51419 12 250 1.74E-62 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 Pfam PF01168 Alanine racemase, N-terminal domain 12 234 4.3E-64 T 17-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 TIGRFAM TIGR00492 alr: alanine racemase 9 376 1.6E-90 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS31425 1c672654fbdb6314428246caf5f7cad6 384 SMART SM01005 249 376 9.9E-63 T 17-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS18520 51bf4f5742cacb51a051ff4bebb5abe7 278 SUPERFAMILY SSF57716 244 277 7.84E-9 T 17-03-2017 SHXM_RS18520 51bf4f5742cacb51a051ff4bebb5abe7 278 PRINTS PR00618 DksA/TraR zinc finger signature 247 258 5.5E-5 T 17-03-2017 IPR020460 Zinc finger, DksA/TraR C4-type, bacteria SHXM_RS18520 51bf4f5742cacb51a051ff4bebb5abe7 278 PRINTS PR00618 DksA/TraR zinc finger signature 259 271 5.5E-5 T 17-03-2017 IPR020460 Zinc finger, DksA/TraR C4-type, bacteria SHXM_RS18520 51bf4f5742cacb51a051ff4bebb5abe7 278 ProSitePatterns PS01102 Prokaryotic dksA C4-type zinc finger. 247 271 - T 17-03-2017 IPR020458 Zinc finger, DksA/TraR C4-type conserved site SHXM_RS18520 51bf4f5742cacb51a051ff4bebb5abe7 278 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 243 277 2.3E-12 T 17-03-2017 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 SHXM_RS18520 51bf4f5742cacb51a051ff4bebb5abe7 278 SUPERFAMILY SSF109635 147 241 4.45E-8 T 17-03-2017 SHXM_RS06595 c1acde0b9b245241ddcd44b07856fd0a 203 SUPERFAMILY SSF46689 11 92 2.1E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS06595 c1acde0b9b245241ddcd44b07856fd0a 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 70 1.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS06595 c1acde0b9b245241ddcd44b07856fd0a 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 45 68 5.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS06595 c1acde0b9b245241ddcd44b07856fd0a 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 5.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS06595 c1acde0b9b245241ddcd44b07856fd0a 203 SUPERFAMILY SSF48498 90 195 1.47E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS06595 c1acde0b9b245241ddcd44b07856fd0a 203 Gene3D G3DSA:1.10.357.10 13 200 1.4E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS02850 c259f8a1e6a3d6c4c4fc503b3ec349ed 435 Gene3D G3DSA:1.20.1250.20 244 426 1.8E-19 T 17-03-2017 SHXM_RS02850 c259f8a1e6a3d6c4c4fc503b3ec349ed 435 Gene3D G3DSA:1.20.1250.20 21 223 2.3E-44 T 17-03-2017 SHXM_RS02850 c259f8a1e6a3d6c4c4fc503b3ec349ed 435 SUPERFAMILY SSF103473 17 432 7.32E-84 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS02850 c259f8a1e6a3d6c4c4fc503b3ec349ed 435 Pfam PF07690 Major Facilitator Superfamily 31 394 7.1E-47 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS45305 f36e0255c338134693a9369c76d6b7df 700 Gene3D G3DSA:1.10.8.60 629 669 2.8E-4 T 17-03-2017 SHXM_RS45305 f36e0255c338134693a9369c76d6b7df 700 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 479 604 3.3E-25 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS45305 f36e0255c338134693a9369c76d6b7df 700 SMART SM00382 474 606 4.0E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45305 f36e0255c338134693a9369c76d6b7df 700 Gene3D G3DSA:3.40.50.300 477 628 1.1E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45305 f36e0255c338134693a9369c76d6b7df 700 SUPERFAMILY SSF52540 431 668 3.64E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Pfam PF11987 Translation-initiation factor 2 844 945 1.2E-33 T 17-03-2017 IPR023115 Translation initiation factor IF- 2, domain 3 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Pfam PF00009 Elongation factor Tu GTP binding domain 553 713 2.1E-32 T 17-03-2017 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Gene3D G3DSA:3.40.50.10050 854 934 3.0E-22 T 17-03-2017 IPR023115 Translation initiation factor IF- 2, domain 3 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 2 51 2.0E-12 T 17-03-2017 IPR006847 Translation initiation factor IF-2, N-terminal SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Pfam PF04760 Translation initiation factor IF-2, N-terminal region 469 514 9.5E-6 T 17-03-2017 IPR006847 Translation initiation factor IF-2, N-terminal SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 TIGRFAM TIGR00487 IF-2: translation initiation factor IF-2 461 1054 6.2E-228 T 17-03-2017 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Hamap MF_00100_B Translation initiation factor IF-2 [infB]. 3 1054 16.621 T 17-03-2017 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Gene3D G3DSA:2.40.30.10 724 818 3.1E-22 T 17-03-2017 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 SUPERFAMILY SSF50447 956 1054 1.52E-24 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 ProSitePatterns PS01176 Initiation factor 2 signature. 1007 1029 - T 17-03-2017 IPR000178 Translation initiation factor aIF-2, bacterial-like GO:0003743|GO:0005525|GO:0005622|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Gene3D G3DSA:2.40.30.10 957 1054 1.7E-29 T 17-03-2017 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 SUPERFAMILY SSF52156 833 962 1.96E-35 T 17-03-2017 IPR023115 Translation initiation factor IF- 2, domain 3 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 551 710 1.1E-28 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 SUPERFAMILY SSF50447 726 809 7.77E-24 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 SUPERFAMILY SSF52540 544 715 7.46E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 PRINTS PR00315 GTP-binding elongation factor signature 552 565 1.3E-9 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 PRINTS PR00315 GTP-binding elongation factor signature 604 614 1.3E-9 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 PRINTS PR00315 GTP-binding elongation factor signature 656 665 1.3E-9 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 PRINTS PR00315 GTP-binding elongation factor signature 620 631 1.3E-9 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS36925 394f672198d2de8733259ed6aade3738 1055 Gene3D G3DSA:3.40.50.300 549 713 2.7E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 Pfam PF00390 Malic enzyme, N-terminal domain 94 226 1.0E-31 T 17-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 Pfam PF03949 Malic enzyme, NAD binding domain 240 462 1.8E-22 T 17-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 PIRSF PIRSF000106 62 468 5.0E-82 T 17-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 SMART SM01274 93 226 3.4E-86 T 17-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 SMART SM00919 238 465 3.3E-112 T 17-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 SUPERFAMILY SSF51735 238 465 2.96E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 Gene3D G3DSA:3.40.50.10380 93 235 3.0E-56 T 17-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 PRINTS PR00072 Malic enzyme signature 155 177 1.4E-11 T 17-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 PRINTS PR00072 Malic enzyme signature 234 250 1.4E-11 T 17-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 PRINTS PR00072 Malic enzyme signature 358 374 1.4E-11 T 17-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 PRINTS PR00072 Malic enzyme signature 265 281 1.4E-11 T 17-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 Gene3D G3DSA:3.30.70.260 22 78 4.2E-4 T 17-03-2017 SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 Gene3D G3DSA:3.40.50.720 236 464 5.4E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23700 44e237431a090cfdf05960f613f1f05f 473 SUPERFAMILY SSF53223 87 236 1.8E-57 T 17-03-2017 SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 132 145 2.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 240 254 2.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 146 159 2.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 PRINTS PR00111 Alpha/beta hydrolase fold signature 87 102 2.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 SUPERFAMILY SSF53474 40 292 1.59E-47 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 Gene3D G3DSA:3.40.50.1820 40 292 2.0E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04275 c2a2267fbac9593e64fcabbc4151b8e0 313 Pfam PF00561 alpha/beta hydrolase fold 62 167 6.8E-24 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 53 60 - T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 8 148 1.8E-45 T 17-03-2017 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 267 276 5.0E-24 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 135 146 5.0E-24 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 53 72 5.0E-24 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 296 319 5.0E-24 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 310 321 3.0E-31 T 17-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 84 97 3.0E-31 T 17-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 124 138 3.0E-31 T 17-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 51 65 3.0E-31 T 17-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 PRINTS PR00102 Ornithine carbamoyltransferase signature 229 239 3.0E-31 T 17-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 SUPERFAMILY SSF53671 4 331 2.23E-93 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 Gene3D G3DSA:3.40.50.1370 145 318 4.2E-64 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 157 329 2.1E-47 T 17-03-2017 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 Hamap MF_01109 Ornithine carbamoyltransferase, catabolic [argI]. 7 332 81.262 T 17-03-2017 IPR024904 Ornithine carbamoyltransferase GO:0004585|GO:0006591 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 TIGRFAM TIGR00658 orni_carb_tr: ornithine carbamoyltransferase 8 331 4.3E-120 T 17-03-2017 IPR002292 Ornithine/putrescine carbamoyltransferase GO:0016743 KEGG: 00220+2.1.3.3|MetaCyc: PWY-4981|MetaCyc: PWY-4984|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS37980 a4ae42e47e76cbc298aad19452080c23 334 Gene3D G3DSA:3.40.50.1370 4 144 1.4E-54 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS03415 71525c6b2705f72ab8ae83c08df34802 270 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS03415 71525c6b2705f72ab8ae83c08df34802 270 SUPERFAMILY SSF52540 9 237 4.41E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03415 71525c6b2705f72ab8ae83c08df34802 270 SMART SM00382 38 218 1.2E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS03415 71525c6b2705f72ab8ae83c08df34802 270 Gene3D G3DSA:3.40.50.300 7 218 7.3E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03415 71525c6b2705f72ab8ae83c08df34802 270 Pfam PF00005 ABC transporter 30 168 6.8E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 Gene3D G3DSA:1.10.1740.10 3 89 1.1E-12 T 17-03-2017 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 Gene3D G3DSA:1.10.10.10 92 149 1.3E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 Gene3D G3DSA:1.25.40.10 183 293 3.8E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 Gene3D G3DSA:1.25.40.10 334 375 3.8E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 SUPERFAMILY SSF88946 3 85 1.84E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 Pfam PF08281 Sigma-70, region 4 98 148 1.2E-7 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 Pfam PF04542 Sigma-70 region 2 5 69 7.4E-9 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS44095 223b883b047bbbd90e694b71bc4fe517 391 SUPERFAMILY SSF88659 91 149 1.72E-8 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 390 5.3E-49 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 SUPERFAMILY SSF56645 13 248 3.27E-79 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 Gene3D G3DSA:2.40.110.10 129 224 3.3E-41 T 17-03-2017 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 Gene3D G3DSA:1.10.540.10 14 125 3.8E-33 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 SUPERFAMILY SSF47203 235 390 4.34E-57 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 131 143 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 349 368 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 129 224 1.7E-27 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 14 125 3.4E-29 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS24290 a68665060dda252c6b9e5f4390a0204e 391 Gene3D G3DSA:1.20.140.10 225 390 2.4E-67 T 17-03-2017 SHXM_RS04045 86e3b25ba87761c48f424cad01a044dd 193 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 1.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04045 86e3b25ba87761c48f424cad01a044dd 193 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 1.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04045 86e3b25ba87761c48f424cad01a044dd 193 SUPERFAMILY SSF46689 7 86 9.98E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04045 86e3b25ba87761c48f424cad01a044dd 193 Gene3D G3DSA:1.10.357.10 8 190 1.4E-43 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04045 86e3b25ba87761c48f424cad01a044dd 193 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 65 1.4E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04045 86e3b25ba87761c48f424cad01a044dd 193 SUPERFAMILY SSF48498 86 189 5.19E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 Pfam PF01839 FG-GAP repeat 351 389 4.9E-8 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 Pfam PF01839 FG-GAP repeat 278 307 4.5E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 Gene3D G3DSA:2.130.10.130 40 196 3.1E-24 T 17-03-2017 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 Gene3D G3DSA:2.130.10.130 281 457 4.8E-24 T 17-03-2017 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 174 242 1.1E-9 T 17-03-2017 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SMART SM00191 347 403 7.4E-7 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SMART SM00191 271 339 5.3 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SMART SM00191 162 208 3.1 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SMART SM00191 27 87 26.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SMART SM00191 99 157 0.33 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SMART SM00191 418 471 51.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS49390 440134f57847c25f6a615feb48e5164a 491 SUPERFAMILY SSF69318 38 446 9.94E-54 T 17-03-2017 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Pfam PF03422 Carbohydrate binding module (family 6) 180 297 2.4E-13 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Pfam PF03422 Carbohydrate binding module (family 6) 48 168 1.3E-11 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SUPERFAMILY SSF49785 42 169 1.05E-25 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Pfam PF01161 Phosphatidylethanolamine-binding protein 844 987 5.5E-20 T 17-03-2017 IPR008914 Phosphatidylethanolamine-binding protein SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SUPERFAMILY SSF49785 179 300 3.72E-24 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Gene3D G3DSA:3.90.280.10 831 986 5.1E-28 T 17-03-2017 IPR008914 Phosphatidylethanolamine-binding protein SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Gene3D G3DSA:2.60.120.260 45 171 5.5E-29 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Gene3D G3DSA:2.60.120.260 178 301 7.5E-31 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Gene3D G3DSA:2.120.10.30 499 819 3.7E-89 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SUPERFAMILY SSF50952 499 806 7.45E-40 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SUPERFAMILY SSF49777 831 981 4.84E-21 T 17-03-2017 IPR008914 Phosphatidylethanolamine-binding protein SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Pfam PF07995 Glucose / Sorbosone dehydrogenase 512 805 7.7E-75 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SMART SM00060 309 385 7.0E-4 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SMART SM00060 406 479 5.5E-8 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Gene3D G3DSA:2.60.40.10 404 490 9.6E-22 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Gene3D G3DSA:2.60.40.10 307 394 9.8E-18 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 Pfam PF00041 Fibronectin type III domain 408 480 1.9E-6 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SUPERFAMILY SSF49265 308 495 5.0E-25 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SMART SM00606 35 170 6.3E-5 T 17-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 SHXM_RS21115 d01edb1a571f1e5909b986b5ed08f190 992 SMART SM00606 184 300 0.0017 T 17-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 SHXM_RS06240 74bcf32c20091061164f6cb5d2b2c085 181 Gene3D G3DSA:3.40.630.30 7 168 1.7E-37 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS06240 74bcf32c20091061164f6cb5d2b2c085 181 Pfam PF13302 Acetyltransferase (GNAT) domain 18 157 5.0E-22 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS06240 74bcf32c20091061164f6cb5d2b2c085 181 SUPERFAMILY SSF55729 10 165 2.16E-30 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS08635 75775b69365a816215ab13ab47f452a9 193 Gene3D G3DSA:1.10.10.60 11 68 5.0E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08635 75775b69365a816215ab13ab47f452a9 193 SUPERFAMILY SSF48498 83 190 1.25E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS08635 75775b69365a816215ab13ab47f452a9 193 Gene3D G3DSA:1.10.357.10 75 191 3.4E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS08635 75775b69365a816215ab13ab47f452a9 193 SUPERFAMILY SSF46689 11 69 1.18E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08635 75775b69365a816215ab13ab47f452a9 193 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 67 2.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Gene3D G3DSA:1.10.510.10 98 257 2.7E-33 T 17-03-2017 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Pfam PF00069 Protein kinase domain 15 256 5.1E-36 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Gene3D G3DSA:2.140.10.10 463 658 2.6E-23 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Gene3D G3DSA:2.140.10.10 358 448 1.5E-8 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SUPERFAMILY SSF56112 12 264 5.66E-59 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SMART SM00220 15 264 4.1E-39 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SUPERFAMILY SSF50998 463 671 5.18E-22 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Pfam PF13360 PQQ-like domain 371 448 3.1E-8 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Pfam PF13360 PQQ-like domain 469 660 6.8E-15 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 Gene3D G3DSA:3.30.200.20 9 93 2.7E-16 T 17-03-2017 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SMART SM00564 500 531 12.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SMART SM00564 620 655 420.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SMART SM00564 455 487 11.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SMART SM00564 376 407 7.7 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SMART SM00564 417 448 1.7 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37060 7299442ef0c819c63816131b31066da6 685 SUPERFAMILY SSF50998 370 490 3.77E-13 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 6 119 2.3E-17 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 SUPERFAMILY SSF51604 119 364 9.43E-62 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 Pfam PF13378 Enolase C-terminal domain-like 149 358 1.2E-50 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 SMART SM00922 146 240 1.0E-24 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 SUPERFAMILY SSF54826 1 119 9.64E-30 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 Gene3D G3DSA:3.30.390.10 1 121 4.4E-42 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS02075 0f2f75542938293f4f699874c91954e4 375 Gene3D G3DSA:3.20.20.120 122 352 1.3E-69 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS06170 287a8706717916b81bda14b77a93406f 62 Pfam PF11706 CGNR zinc finger 16 56 4.5E-16 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS06170 287a8706717916b81bda14b77a93406f 62 SUPERFAMILY SSF160904 3 56 6.54E-18 T 17-03-2017 SHXM_RS06170 287a8706717916b81bda14b77a93406f 62 Gene3D G3DSA:1.10.3300.10 2 58 3.4E-18 T 17-03-2017 IPR023286 ABATE domain SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 99 113 2.3E-20 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 321 332 2.3E-20 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 165 187 2.3E-20 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 209 229 2.3E-20 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 107 120 - T 17-03-2017 IPR033524 Leu/Phe/Val dehydrogenases active site Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 252 328 6.0E-7 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 SMART SM00839 177 383 1.5E-39 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 SUPERFAMILY SSF51735 174 380 2.54E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 Gene3D G3DSA:3.40.50.720 181 371 2.5E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 SUPERFAMILY SSF53223 39 177 9.28E-41 T 17-03-2017 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 47 164 2.0E-24 T 17-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 Gene3D G3DSA:3.40.192.10 39 180 7.2E-59 T 17-03-2017 SHXM_RS29425 3c6815a877206a41cfd2c57c5b014f47 384 PIRSF PIRSF000188 31 384 3.7E-138 T 17-03-2017 IPR016211 Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal GO:0016639|GO:0055114 SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 SMART SM00866 96 236 3.5E-33 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 SMART SM00345 16 75 9.9E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 Gene3D G3DSA:3.40.1410.10 83 240 6.6E-48 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 SUPERFAMILY SSF46785 11 77 6.63E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 Gene3D G3DSA:1.10.10.10 12 78 4.5E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 75 6.1E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 SUPERFAMILY SSF64288 66 241 5.18E-45 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 35 49 5.4E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 65 5.4E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49560 8939eb9b534ab0dfb8de12f8d17a4069 247 Pfam PF07702 UTRA domain 96 236 9.9E-40 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS26500 8ab5ff35c7f259b663dfd8b804cf4a4f 470 SUPERFAMILY SSF53383 31 456 3.11E-127 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS26500 8ab5ff35c7f259b663dfd8b804cf4a4f 470 TIGRFAM TIGR01788 Glu-decarb-GAD: glutamate decarboxylase 38 454 3.6E-187 T 17-03-2017 IPR010107 Glutamate decarboxylase GO:0004351|GO:0006536|GO:0030170 KEGG: 00250+4.1.1.15|KEGG: 00410+4.1.1.15|KEGG: 00430+4.1.1.15|KEGG: 00650+4.1.1.15|MetaCyc: PWY-4321 SHXM_RS26500 8ab5ff35c7f259b663dfd8b804cf4a4f 470 Gene3D G3DSA:3.40.640.10 83 335 2.9E-25 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS26500 8ab5ff35c7f259b663dfd8b804cf4a4f 470 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 55 387 1.1E-70 T 17-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 SHXM_RS19985 7c740752acf14d887993131d8b85ec0e 216 Pfam PF13419 Haloacid dehalogenase-like hydrolase 9 181 8.6E-19 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19985 7c740752acf14d887993131d8b85ec0e 216 Gene3D G3DSA:3.40.50.1000 72 203 2.8E-36 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19985 7c740752acf14d887993131d8b85ec0e 216 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 131 181 2.1E-15 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS19985 7c740752acf14d887993131d8b85ec0e 216 Gene3D G3DSA:1.10.150.240 22 64 2.5E-6 T 17-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 SHXM_RS19985 7c740752acf14d887993131d8b85ec0e 216 SUPERFAMILY SSF56784 6 200 7.6E-41 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19985 7c740752acf14d887993131d8b85ec0e 216 ProSitePatterns PS01228 Hypothetical cof family signature 1. 7 18 - T 17-03-2017 IPR000150 Cof protein GO:0016787 SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 Gene3D G3DSA:1.10.10.10 21 88 1.3E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 SUPERFAMILY SSF46785 19 88 2.36E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 58 4.0E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 58 74 4.0E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 Gene3D G3DSA:1.20.120.530 105 228 8.4E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 Pfam PF00392 Bacterial regulatory proteins, gntR family 21 84 7.1E-23 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 SMART SM00345 25 84 3.1E-23 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 SMART SM00895 108 229 6.7E-24 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 SUPERFAMILY SSF48008 105 231 2.88E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS11700 bbea2e2796d78dfcc6ebcfb9b80be879 262 Pfam PF07729 FCD domain 108 227 5.0E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Gene3D G3DSA:3.20.20.80 319 618 2.6E-97 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Pfam PF02929 Beta galactosidase small chain 764 1000 4.9E-49 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 ProSitePatterns PS00719 Glycosyl hydrolases family 2 signature 1. 370 395 - T 17-03-2017 IPR023230 Glycoside hydrolase, family 2, conserved site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 SUPERFAMILY SSF49303 619 729 1.87E-17 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 430 444 - T 17-03-2017 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Gene3D G3DSA:2.60.40.320 634 732 1.0E-17 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Gene3D G3DSA:2.70.98.10 763 1004 2.1E-62 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Gene3D G3DSA:2.60.40.320 195 318 5.3E-24 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 SUPERFAMILY SSF49303 208 318 2.4E-11 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 SUPERFAMILY SSF49785 18 206 1.32E-42 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 SUPERFAMILY SSF74650 763 1004 2.67E-63 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 49 204 2.4E-26 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 PRINTS PR00132 Glycosyl hydrolase family 2 signature 430 445 3.2E-25 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 PRINTS PR00132 Glycosyl hydrolase family 2 signature 508 523 3.2E-25 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 PRINTS PR00132 Glycosyl hydrolase family 2 signature 360 378 3.2E-25 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 PRINTS PR00132 Glycosyl hydrolase family 2 signature 329 343 3.2E-25 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Pfam PF16353 Domain of unknown function(DUF4981) 634 727 8.7E-15 T 17-03-2017 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Pfam PF00703 Glycosyl hydrolases family 2 265 318 3.0E-6 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 SUPERFAMILY SSF51445 320 617 3.3E-85 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Gene3D G3DSA:2.60.120.260 18 194 9.9E-49 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 SMART SM01038 748 1002 9.8E-70 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS46960 2a48f5c3b39cd5e14411b9e6fd699b4c 1004 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 320 621 3.7E-85 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 3174 3356 1.48E-41 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF13745 HxxPF-repeated domain 944 1034 4.0E-23 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF56801 2557 3111 2.35E-148 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00455 Putative AMP-binding domain signature. 5761 5772 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 4698 4879 2.33E-38 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2737 2748 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF56801 1046 1608 1.57E-153 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00550 Phosphopantetheine attachment site 6128 6191 8.3E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00550 Phosphopantetheine attachment site 4624 4684 4.4E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00550 Phosphopantetheine attachment site 3101 3160 1.0E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00550 Phosphopantetheine attachment site 1597 1659 1.3E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00550 Phosphopantetheine attachment site 537 599 2.7E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 5352 5620 1.33E-59 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:1.10.1200.10 4627 4690 1.0E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:1.10.1200.10 1600 1663 1.0E-27 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:1.10.1200.10 6131 6193 1.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:1.10.1200.10 541 600 8.3E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:1.10.1200.10 3103 3163 2.4E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 3835 4082 1.56E-56 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00455 Putative AMP-binding domain signature. 172 183 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:2.30.38.10 2902 2978 9.8E-26 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:2.30.38.10 337 414 8.8E-28 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:2.30.38.10 5925 6000 4.7E-27 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:2.30.38.10 1399 1476 1.4E-27 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:2.30.38.10 4425 4503 1.4E-25 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00012 Phosphopantetheine attachment site. 559 574 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF56801 24 548 3.66E-149 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF13193 AMP-binding enzyme C-terminal domain 432 508 9.2E-11 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF13193 AMP-binding enzyme C-terminal domain 2997 3072 1.5E-10 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF13193 AMP-binding enzyme C-terminal domain 1494 1568 5.4E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF13193 AMP-binding enzyme C-terminal domain 6020 6096 2.6E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF13193 AMP-binding enzyme C-terminal domain 4521 4596 1.6E-11 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF47336 4615 4684 4.45E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 3368 3620 2.11E-36 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 5653 6036 9.4E-130 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2616 3013 2.2E-130 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1108 1509 1.3E-127 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 61 448 6.0E-130 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 4135 4536 5.2E-128 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SMART SM00823 Phosphopantetheine attachment site 3099 3167 8.2E-4 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SMART SM00823 Phosphopantetheine attachment site 4622 4690 0.029 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SMART SM00823 Phosphopantetheine attachment site 535 604 7.3E-4 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SMART SM00823 Phosphopantetheine attachment site 1595 1663 6.6E-6 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SMART SM00823 Phosphopantetheine attachment site 6126 6195 0.0016 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 1080 1243 1.1E-47 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 4109 4272 1.2E-49 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 36 194 2.4E-41 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 2588 2761 2.5E-43 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 5625 5782 6.2E-47 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 2132 2315 6.67E-38 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 1849 2095 2.0E-43 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 4703 5002 6.2E-56 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 623 921 6.1E-69 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 3178 3482 7.2E-56 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 1679 1962 1.5E-46 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 5169 5469 2.7E-54 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 3652 3952 1.4E-64 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00668 Condensation domain 2127 2433 1.1E-55 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1619 1634 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1969 2119 3.0E-34 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 3489 3644 3.0E-37 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 5009 5161 3.3E-36 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF47336 528 600 9.07E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4646 4661 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.30.559.10 5225 5337 8.0E-4 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF56801 5595 6139 1.57E-158 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 1677 1837 6.97E-37 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00501 AMP-binding enzyme 41 424 2.2E-87 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00501 AMP-binding enzyme 4114 4513 3.0E-91 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00501 AMP-binding enzyme 5632 6011 1.8E-94 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00501 AMP-binding enzyme 1087 1486 5.0E-90 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Pfam PF00501 AMP-binding enzyme 2595 2989 1.4E-92 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 2765 2901 7.3E-33 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 195 336 7.0E-37 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 5783 5924 1.2E-36 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1235 1246 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF47336 6119 6192 4.58E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 3657 3834 8.89E-43 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF56801 4072 4635 5.76E-150 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.30.300.30 4508 4626 7.5E-41 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.30.300.30 6007 6130 7.0E-37 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.30.300.30 1481 1599 2.2E-41 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.30.300.30 2984 3102 3.9E-36 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.30.300.30 419 540 1.5E-40 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 618 823 5.71E-48 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 4891 5137 2.11E-38 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 811 1051 2.78E-59 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 5174 5351 1.67E-37 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF47336 3091 3161 1.44E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3123 3138 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6150 6165 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF52777 2318 2583 3.78E-56 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 4273 4424 2.3E-28 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 Gene3D G3DSA:3.40.50.980 1244 1398 9.6E-31 T 17-03-2017 SHXM_RS04075 d54c41f1f2d5acc0468e9affc54ec716 6212 SUPERFAMILY SSF47336 1587 1659 8.38E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38510 4526931db874028526c053f18bf677e7 369 SUPERFAMILY SSF49384 267 360 2.79E-29 T 17-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 SHXM_RS38510 4526931db874028526c053f18bf677e7 369 SUPERFAMILY SSF81296 48 243 2.38E-42 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS38510 4526931db874028526c053f18bf677e7 369 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 48 239 1.6E-39 T 17-03-2017 IPR004302 Chitin-binding protein, N-terminal SHXM_RS38510 4526931db874028526c053f18bf677e7 369 ProSitePatterns PS00561 CBM2a (carbohydrate-binding type-2) domain signature. 337 350 - T 17-03-2017 IPR018366 Carbohydrate-binding type-2, conserved site GO:0004553|GO:0005975|GO:0030246 SHXM_RS38510 4526931db874028526c053f18bf677e7 369 SMART SM00637 272 366 3.5E-31 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS38510 4526931db874028526c053f18bf677e7 369 Pfam PF00553 Cellulose binding domain 272 361 1.0E-25 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS38510 4526931db874028526c053f18bf677e7 369 Gene3D G3DSA:2.70.50.50 48 242 5.2E-48 T 17-03-2017 SHXM_RS38510 4526931db874028526c053f18bf677e7 369 Gene3D G3DSA:2.60.40.290 271 361 1.3E-30 T 17-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 Gene3D G3DSA:1.10.1060.10 16 128 2.0E-20 T 17-03-2017 SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 106 117 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 61 72 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 SUPERFAMILY SSF54862 34 151 4.18E-28 T 17-03-2017 SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 Pfam PF12838 4Fe-4S dicluster domain 60 120 1.2E-11 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 TIGRFAM TIGR01971 NuoI: NADH-quinone oxidoreductase, chain I 17 144 2.7E-44 T 17-03-2017 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30795 20cd25eff9e0f3ed8f990d8476b06596 211 Hamap MF_01351 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic [ndhI]. 8 150 28.396 T 17-03-2017 IPR010226 NADH-quinone oxidoreductase, chain I GO:0016020|GO:0016651|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 Gene3D G3DSA:3.30.420.40 79 218 1.7E-39 T 17-03-2017 SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 SUPERFAMILY SSF53067 81 389 5.94E-55 T 17-03-2017 SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 Gene3D G3DSA:1.10.10.10 7 75 4.2E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 SUPERFAMILY SSF46785 8 69 2.58E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 Gene3D G3DSA:3.30.420.40 219 372 5.5E-49 T 17-03-2017 SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 Pfam PF00480 ROK family 82 372 4.3E-52 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS11440 1eb7d05caf3c70aa582c613bd20cac70 411 ProSitePatterns PS01125 ROK family signature. 215 242 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS02000 af56f8c5fb429e38e7ddd5481102187a 257 Pfam PF00005 ABC transporter 34 162 1.4E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS02000 af56f8c5fb429e38e7ddd5481102187a 257 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS02000 af56f8c5fb429e38e7ddd5481102187a 257 SUPERFAMILY SSF52540 19 215 7.1E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02000 af56f8c5fb429e38e7ddd5481102187a 257 SMART SM00382 43 212 5.9E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02000 af56f8c5fb429e38e7ddd5481102187a 257 Gene3D G3DSA:3.40.50.300 15 217 2.2E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 SUPERFAMILY SSF55021 459 530 1.12E-13 T 17-03-2017 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Gene3D G3DSA:3.30.1330.90 323 450 2.0E-43 T 17-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Gene3D G3DSA:3.40.50.720 113 288 1.1E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 SUPERFAMILY SSF51735 107 286 7.74E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 197 219 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Gene3D G3DSA:3.30.70.260 451 528 8.3E-17 T 17-03-2017 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 TIGRFAM TIGR01327 PGDH: phosphoglycerate dehydrogenase 11 531 4.8E-185 T 17-03-2017 IPR006236 D-3-phosphoglycerate dehydrogenase GO:0004617|GO:0006564 KEGG: 00260+1.1.1.95|KEGG: 00680+1.1.1.95|Reactome: R-HSA-977347 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 113 286 4.1E-62 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Gene3D G3DSA:3.40.50.720 8 112 6.2E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Pfam PF01842 ACT domain 463 520 3.6E-8 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 149 176 - T 17-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 SUPERFAMILY SSF143548 325 454 1.18E-33 T 17-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 SUPERFAMILY SSF52283 8 140 8.13E-36 T 17-03-2017 SHXM_RS36170 28f544db451ef7a8dd62ac0e500b8cde 533 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 11 318 9.4E-32 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS03660 5542d0c865c51454ddce4c20eb36c32c 160 Gene3D G3DSA:3.10.180.10 5 131 2.0E-44 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS03660 5542d0c865c51454ddce4c20eb36c32c 160 Pfam PF06983 3-demethylubiquinone-9 3-methyltransferase 6 119 8.6E-48 T 17-03-2017 IPR028973 PhnB-like SHXM_RS03660 5542d0c865c51454ddce4c20eb36c32c 160 PIRSF PIRSF021700 1 159 8.2E-61 T 17-03-2017 IPR009725 Predicted 3-demethylubiquinone-9 3-methyltransferase SHXM_RS03660 5542d0c865c51454ddce4c20eb36c32c 160 SUPERFAMILY SSF54593 6 158 1.45E-50 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 SUPERFAMILY SSF51735 3 241 3.4E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 204 224 2.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 2.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 2.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 2.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 2.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 2.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 76 87 6.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 6.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 6.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 8 240 2.1E-57 T 17-03-2017 SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 Gene3D G3DSA:3.40.50.720 3 242 3.5E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41030 06516adcda38282f8c73c9e02a92f517 293 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2 181 3.0E-4 T 17-03-2017 SHXM_RS46100 bb765c72abf65c40537650202581c64b 273 Gene3D G3DSA:3.40.50.300 12 247 8.3E-85 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46100 bb765c72abf65c40537650202581c64b 273 PIRSF PIRSF039085 9 252 7.8E-114 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS46100 bb765c72abf65c40537650202581c64b 273 Pfam PF00005 ABC transporter 28 176 3.0E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46100 bb765c72abf65c40537650202581c64b 273 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS46100 bb765c72abf65c40537650202581c64b 273 SMART SM00382 37 224 1.9E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS46100 bb765c72abf65c40537650202581c64b 273 SUPERFAMILY SSF52540 13 246 4.44E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40470 4f0f019676d8f67dfcd7eb719aae371d 336 Gene3D G3DSA:3.20.20.100 9 318 9.0E-107 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS40470 4f0f019676d8f67dfcd7eb719aae371d 336 Pfam PF00248 Aldo/keto reductase family 16 312 3.5E-74 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS40470 4f0f019676d8f67dfcd7eb719aae371d 336 SUPERFAMILY SSF51430 1 317 6.42E-107 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS40470 4f0f019676d8f67dfcd7eb719aae371d 336 PRINTS PR00069 Aldo-keto reductase signature 113 131 6.2E-5 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS40470 4f0f019676d8f67dfcd7eb719aae371d 336 PRINTS PR00069 Aldo-keto reductase signature 247 271 6.2E-5 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SUPERFAMILY SSF49785 866 997 1.53E-12 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Pfam PF03422 Carbohydrate binding module (family 6) 874 988 1.3E-11 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Gene3D G3DSA:2.80.10.50 506 595 3.4E-14 T 17-03-2017 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SUPERFAMILY SSF51445 11 371 4.42E-75 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 372 744 1.3E-55 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 PRINTS PR00133 Glycosyl hydrolase family 3 signature 162 178 1.7E-6 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 PRINTS PR00133 Glycosyl hydrolase family 3 signature 74 93 1.7E-6 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Pfam PF14310 Fibronectin type III-like domain 776 847 4.3E-18 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Gene3D G3DSA:2.60.120.260 873 997 1.3E-18 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Gene3D G3DSA:3.20.20.300 11 324 3.8E-85 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SUPERFAMILY SSF50405 507 593 7.33E-11 T 17-03-2017 IPR008999 Actin cross-linking SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 54 314 3.4E-39 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Gene3D G3DSA:3.40.50.1700 600 747 4.2E-58 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 Gene3D G3DSA:3.40.50.1700 358 437 4.2E-58 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SMART SM00606 866 998 2.6E-8 T 17-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SUPERFAMILY SSF52279 600 747 1.57E-44 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SUPERFAMILY SSF52279 372 438 1.57E-44 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS36825 14c1965cc135fed2842b9df200951797 998 SMART SM01217 776 847 9.7E-24 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS15260 f5a92b7de800dff77efd68be969a4f18 366 SUPERFAMILY SSF53098 168 322 4.55E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15260 f5a92b7de800dff77efd68be969a4f18 366 Pfam PF13683 Integrase core domain 256 320 5.5E-13 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15260 f5a92b7de800dff77efd68be969a4f18 366 Pfam PF13276 HTH-like domain 104 152 2.9E-7 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS15260 f5a92b7de800dff77efd68be969a4f18 366 SUPERFAMILY SSF46689 64 147 1.67E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15260 f5a92b7de800dff77efd68be969a4f18 366 Gene3D G3DSA:3.30.420.10 166 320 1.1E-15 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 20 319 4.2E-116 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 Pfam PF13732 Domain of unknown function (DUF4162) 225 317 1.8E-6 T 17-03-2017 IPR025302 Domain of unknown function DUF4162 SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 ProSitePatterns PS00211 ABC transporters family signature. 144 158 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 SUPERFAMILY SSF52540 13 234 1.36E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 SMART SM00382 37 228 2.8E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 Gene3D G3DSA:3.40.50.300 6 235 1.6E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19395 838eb3d8a7430364aa9599876906fd08 336 Pfam PF00005 ABC transporter 29 171 1.1E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS47600 d382b6ba76180f25f3a179d52978fd68 287 SUPERFAMILY SSF47413 33 83 2.14E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47600 d382b6ba76180f25f3a179d52978fd68 287 Pfam PF13560 Helix-turn-helix domain 9 87 2.9E-15 T 17-03-2017 SHXM_RS47600 d382b6ba76180f25f3a179d52978fd68 287 SMART SM00530 13 85 3.0E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS47600 d382b6ba76180f25f3a179d52978fd68 287 Gene3D G3DSA:1.10.260.40 7 84 7.7E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 Gene3D G3DSA:1.10.510.10 433 455 9.5E-56 T 17-03-2017 SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 Gene3D G3DSA:1.10.510.10 117 276 9.5E-56 T 17-03-2017 SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 138 150 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 Pfam PF00069 Protein kinase domain 10 272 3.9E-52 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 SMART SM00220 8 278 1.7E-72 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 SUPERFAMILY SSF56112 422 471 5.13E-79 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 SUPERFAMILY SSF56112 5 278 5.13E-79 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS23875 70376427d0efcc41263ea42d55f7ac91 574 Gene3D G3DSA:3.30.200.20 5 116 1.6E-21 T 17-03-2017 SHXM_RS01985 30d3f9803aff462d26bfdb07db7bc14d 448 SUPERFAMILY SSF51679 1 433 1.31E-116 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01985 30d3f9803aff462d26bfdb07db7bc14d 448 Pfam PF00296 Luciferase-like monooxygenase 25 382 5.6E-57 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01985 30d3f9803aff462d26bfdb07db7bc14d 448 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 10 427 6.7E-133 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS01985 30d3f9803aff462d26bfdb07db7bc14d 448 PIRSF PIRSF000337 1 441 2.4E-146 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS01985 30d3f9803aff462d26bfdb07db7bc14d 448 Gene3D G3DSA:3.20.20.30 347 434 3.7E-122 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01985 30d3f9803aff462d26bfdb07db7bc14d 448 Gene3D G3DSA:3.20.20.30 2 303 3.7E-122 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS29110 bfe3549eaae1f48359582a2fa2078371 531 Gene3D G3DSA:1.20.1250.20 294 478 1.0E-19 T 17-03-2017 SHXM_RS29110 bfe3549eaae1f48359582a2fa2078371 531 Gene3D G3DSA:1.20.1250.20 47 255 3.2E-28 T 17-03-2017 SHXM_RS29110 bfe3549eaae1f48359582a2fa2078371 531 ProSitePatterns PS00217 Sugar transport proteins signature 2. 159 184 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS29110 bfe3549eaae1f48359582a2fa2078371 531 SUPERFAMILY SSF103473 47 481 8.63E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS29110 bfe3549eaae1f48359582a2fa2078371 531 Pfam PF00083 Sugar (and other) transporter 52 482 1.4E-51 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS29110 bfe3549eaae1f48359582a2fa2078371 531 ProSitePatterns PS00216 Sugar transport proteins signature 1. 349 366 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS42315 61e7d81fda69d5144c72fbf5010c205b 382 Pfam PF13006 Insertion element 4 transposase N-terminal 1 95 6.6E-31 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS42315 61e7d81fda69d5144c72fbf5010c205b 382 SUPERFAMILY SSF53098 110 352 9.1E-25 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS42315 61e7d81fda69d5144c72fbf5010c205b 382 Pfam PF01609 Transposase DDE domain 112 338 2.0E-20 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS50390 61e7d81fda69d5144c72fbf5010c205b 382 Pfam PF13006 Insertion element 4 transposase N-terminal 1 95 6.6E-31 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS50390 61e7d81fda69d5144c72fbf5010c205b 382 SUPERFAMILY SSF53098 110 352 9.1E-25 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50390 61e7d81fda69d5144c72fbf5010c205b 382 Pfam PF01609 Transposase DDE domain 112 338 2.0E-20 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS42020 61e7d81fda69d5144c72fbf5010c205b 382 Pfam PF13006 Insertion element 4 transposase N-terminal 1 95 6.6E-31 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS42020 61e7d81fda69d5144c72fbf5010c205b 382 SUPERFAMILY SSF53098 110 352 9.1E-25 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS42020 61e7d81fda69d5144c72fbf5010c205b 382 Pfam PF01609 Transposase DDE domain 112 338 2.0E-20 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Gene3D G3DSA:3.40.50.300 15 214 3.2E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 SUPERFAMILY SSF54980 418 513 5.28E-23 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 SUPERFAMILY SSF54980 311 390 6.12E-20 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Gene3D G3DSA:3.30.70.240 420 508 5.6E-20 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Gene3D G3DSA:3.30.70.870 311 388 1.1E-25 T 17-03-2017 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Hamap MF_00071 Elongation factor 4 [lepA]. 1 617 284.986 T 17-03-2017 IPR006297 Elongation factor 4 GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 PRINTS PR00315 GTP-binding elongation factor signature 64 72 4.2E-13 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 PRINTS PR00315 GTP-binding elongation factor signature 146 155 4.2E-13 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 PRINTS PR00315 GTP-binding elongation factor signature 94 104 4.2E-13 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 PRINTS PR00315 GTP-binding elongation factor signature 110 121 4.2E-13 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 PRINTS PR00315 GTP-binding elongation factor signature 21 34 4.2E-13 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 21 194 5.3E-18 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Pfam PF00679 Elongation factor G C-terminus 418 503 2.5E-20 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Pfam PF00009 Elongation factor Tu GTP binding domain 19 201 2.0E-50 T 17-03-2017 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 SUPERFAMILY SSF50447 202 299 8.08E-17 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 57 72 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 SUPERFAMILY SSF52540 18 225 9.68E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Pfam PF03144 Elongation factor Tu domain 2 225 295 1.2E-7 T 17-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 TIGRFAM TIGR01393 lepA: elongation factor 4 19 615 6.3E-291 T 17-03-2017 IPR006297 Elongation factor 4 GO:0005525 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 SMART SM00838 417 501 0.0012 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Gene3D G3DSA:2.40.30.10 215 307 5.1E-19 T 17-03-2017 SHXM_RS21325 362508844691a8e73df6047e8ae69338 625 Pfam PF06421 GTP-binding protein LepA C-terminus 508 613 6.6E-49 T 17-03-2017 IPR013842 GTP-binding protein LepA, C-terminal SHXM_RS13940 9287945620a91300e63f15f2b7bf63b5 46 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 2 41 1.4E-10 T 17-03-2017 SHXM_RS13940 9287945620a91300e63f15f2b7bf63b5 46 Gene3D G3DSA:3.40.50.720 2 41 5.7E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13940 9287945620a91300e63f15f2b7bf63b5 46 SUPERFAMILY SSF51735 2 41 1.34E-11 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS26950 e8678b3c6ec25332c4e6157c99c2a045 472 SUPERFAMILY SSF88713 91 132 1.89E-22 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS26950 e8678b3c6ec25332c4e6157c99c2a045 472 SUPERFAMILY SSF88713 162 393 1.89E-22 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS26950 e8678b3c6ec25332c4e6157c99c2a045 472 Gene3D G3DSA:3.20.20.370 300 392 1.0E-6 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS26950 e8678b3c6ec25332c4e6157c99c2a045 472 Gene3D G3DSA:3.20.20.370 83 262 1.0E-6 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 Gene3D G3DSA:3.30.420.40 161 187 1.7E-23 T 17-03-2017 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 Gene3D G3DSA:3.30.420.40 265 319 1.7E-23 T 17-03-2017 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 Gene3D G3DSA:3.30.420.40 12 160 6.7E-19 T 17-03-2017 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 Gene3D G3DSA:3.90.640.10 188 261 1.5E-10 T 17-03-2017 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 SUPERFAMILY SSF53067 150 330 3.05E-30 T 17-03-2017 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 Pfam PF06723 MreB/Mbl protein 11 332 3.2E-101 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 SUPERFAMILY SSF53067 11 149 9.55E-20 T 17-03-2017 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 188 208 1.8E-34 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 302 328 1.8E-34 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 48 66 1.8E-34 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 133 152 1.8E-34 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS26555 c085c207d2a345a4f4f022ab7559b9a9 345 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 68 91 1.8E-34 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 ProSitePatterns PS01081 TetR-type HTH domain signature. 24 55 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 55 8.9E-16 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 3.0E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 3.0E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 Gene3D G3DSA:1.10.357.10 54 183 5.0E-16 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 Gene3D G3DSA:1.10.10.60 11 53 8.8E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10375 5dc46a5a5eb1287e8cb6a7e1851c3275 191 SUPERFAMILY SSF46689 9 76 1.7E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31885 6d614aeb924705fcc9ec2a181bfff946 374 SUPERFAMILY SSF101478 19 349 1.83E-68 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS31885 6d614aeb924705fcc9ec2a181bfff946 374 Pfam PF03747 ADP-ribosylglycohydrolase 26 328 2.0E-70 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS07425 27b466d71e0550cb53f34de65e91ead0 285 SUPERFAMILY SSF47413 13 72 2.12E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS07425 27b466d71e0550cb53f34de65e91ead0 285 Pfam PF13560 Helix-turn-helix domain 15 74 1.2E-14 T 17-03-2017 SHXM_RS07425 27b466d71e0550cb53f34de65e91ead0 285 SMART SM00530 18 73 3.6E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS07425 27b466d71e0550cb53f34de65e91ead0 285 Gene3D G3DSA:1.10.260.40 10 72 4.3E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49840 4eccc9ad07024b31f9f0b07ed04201ca 299 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 23 280 5.4E-13 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS49840 4eccc9ad07024b31f9f0b07ed04201ca 299 SUPERFAMILY SSF56219 18 289 1.96E-24 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS49840 4eccc9ad07024b31f9f0b07ed04201ca 299 Gene3D G3DSA:3.60.10.10 14 288 6.7E-11 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 Gene3D G3DSA:3.10.310.10 141 241 2.2E-26 T 17-03-2017 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 Pfam PF01678 Diaminopimelate epimerase 141 238 9.1E-14 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 Pfam PF01678 Diaminopimelate epimerase 3 97 4.0E-15 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 SUPERFAMILY SSF54506 1 118 5.97E-22 T 17-03-2017 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 TIGRFAM TIGR00652 DapF: diaminopimelate epimerase 1 265 1.3E-53 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 ProSitePatterns PS01326 Diaminopimelate epimerase signature. 65 79 - T 17-03-2017 IPR018510 Diaminopimelate epimerase, active site GO:0005737|GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 SUPERFAMILY SSF54506 127 264 1.92E-26 T 17-03-2017 SHXM_RS32230 89b36f36f868c2c4fa1b232e01f8ae13 266 Gene3D G3DSA:3.10.310.10 1 140 3.2E-27 T 17-03-2017 SHXM_RS03570 fdf114e74a8e848341994038b9d58944 445 SUPERFAMILY SSF102114 158 413 1.79E-9 T 17-03-2017 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 Pfam PF04542 Sigma-70 region 2 55 124 1.2E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 51 272 3.9E-95 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 PRINTS PR00046 Major sigma-70 factor signature 79 92 2.3E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 PRINTS PR00046 Major sigma-70 factor signature 243 258 2.3E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 PRINTS PR00046 Major sigma-70 factor signature 226 238 2.3E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 SUPERFAMILY SSF88659 191 273 1.36E-17 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 Pfam PF04545 Sigma-70, region 4 222 271 1.1E-18 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 Gene3D G3DSA:1.10.10.10 123 178 4.2E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 Gene3D G3DSA:1.10.10.10 214 273 1.7E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 SUPERFAMILY SSF88659 128 203 1.48E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 Pfam PF04539 Sigma-70 region 3 136 201 1.6E-11 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 52 272 3.4E-36 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 SUPERFAMILY SSF88946 18 124 5.97E-31 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 Gene3D G3DSA:1.10.601.10 45 122 3.2E-24 T 17-03-2017 SHXM_RS27365 e18a2221a0dbc331ca5806b9065e269a 276 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 79 92 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 399 545 1.3E-37 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 435 454 - T 17-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 SUPERFAMILY SSF52518 374 557 1.14E-51 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 4 167 1.3E-40 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 Gene3D G3DSA:3.40.50.1220 183 340 1.8E-44 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 Gene3D G3DSA:3.40.50.970 348 554 1.3E-57 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 SUPERFAMILY SSF52518 4 171 2.19E-38 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 SUPERFAMILY SSF52467 183 337 1.41E-42 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 SUPERFAMILY SSF52467 370 388 1.41E-42 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 Gene3D G3DSA:3.40.50.970 4 170 1.3E-41 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS49415 0d7ae97f7ccedb84c8c9d22c9f16f2ba 573 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 191 329 7.4E-35 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS18275 66da6b7621864af0589f996d8dad1e15 143 SMART SM00345 18 77 2.2E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS18275 66da6b7621864af0589f996d8dad1e15 143 SUPERFAMILY SSF46785 7 79 8.37E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18275 66da6b7621864af0589f996d8dad1e15 143 Gene3D G3DSA:1.10.10.10 5 78 8.4E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18275 66da6b7621864af0589f996d8dad1e15 143 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 77 3.3E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF53901 31 399 1.69E-98 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF51735 1748 2006 1.66E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF52151 573 700 6.28E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF52151 767 866 6.28E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.40.47.10 297 463 4.6E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 535 2.5E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.90.180.10 1439 1515 1.4E-9 T 17-03-2017 IPR011032 GroES-like SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.40.50.720 1751 1935 2.4E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.40.50.720 1528 1715 1.2E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF51735 1535 1670 9.86E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 575 875 1.5E-112 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF08659 KR domain 1751 1929 9.4E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.40.47.10 30 296 1.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM00825 Beta-ketoacyl synthase 36 462 4.5E-211 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.40.366.10 766 876 2.7E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.40.366.10 573 694 2.7E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM01294 2038 2108 1.7E-4 T 17-03-2017 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF47336 2031 2112 1.27E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF00698 Acyl transferase domain 574 894 4.3E-83 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1458 1513 1.5E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF13602 Zinc-binding dehydrogenase 1612 1741 1.7E-16 T 17-03-2017 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM00829 1438 1741 9.5E-167 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF14765 Polyketide synthase dehydratase 944 1222 4.0E-56 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2064 2079 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF55048 698 766 1.57E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM00826 944 1108 1.8E-83 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF51735 1230 1414 1.85E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:3.30.70.250 700 765 1.6E-8 T 17-03-2017 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SUPERFAMILY SSF50129 1435 1565 8.98E-25 T 17-03-2017 IPR011032 GroES-like SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF08990 Erythronolide synthase docking 2 27 2.7E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF00550 Phosphopantetheine attachment site 2040 2105 7.9E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 2.6E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM00823 Phosphopantetheine attachment site 2037 2109 1.6E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 5.0E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1751 1931 1.1E-57 T 17-03-2017 SHXM_RS06390 18454fb37cfef347f5ec96b815b85207 2197 Gene3D G3DSA:1.10.1200.10 2033 2109 1.8E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 Gene3D G3DSA:3.40.50.790 69 159 3.2E-41 T 17-03-2017 IPR016095 Ribosomal protein L1, 3-layer alpha/beta-sandwich SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 TIGRFAM TIGR01169 rplA_bact: ribosomal protein uL1 3 227 4.0E-102 T 17-03-2017 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 Hamap MF_01318_B 50S ribosomal protein L1 [rplA]. 2 229 42.864 T 17-03-2017 IPR005878 Ribosomal protein L1, bacterial-type GO:0003723|GO:0003735|GO:0006412|GO:0015934 SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 PIRSF PIRSF002155 1 227 8.4E-75 T 17-03-2017 IPR002143 Ribosomal protein L1 GO:0003723|GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 Gene3D G3DSA:3.30.190.20 17 68 1.2E-45 T 17-03-2017 IPR016094 Ribosomal protein L1, 2-layer alpha/beta-sandwich GO:0003723 SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 Gene3D G3DSA:3.30.190.20 161 226 1.2E-45 T 17-03-2017 IPR016094 Ribosomal protein L1, 2-layer alpha/beta-sandwich GO:0003723 SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 SUPERFAMILY SSF56808 7 226 4.58E-82 T 17-03-2017 IPR023674 Ribosomal protein L1-like SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 Pfam PF00687 Ribosomal protein L1p/L10e family 32 220 6.9E-54 T 17-03-2017 IPR028364 Ribosomal protein L1/ribosomal biogenesis protein SHXM_RS31090 effb7a2168b957bb5928d836ca235bfc 239 ProSitePatterns PS01199 Ribosomal protein L1 signature. 121 139 - T 17-03-2017 IPR023673 Ribosomal protein L1, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS19675 acd1a74f2f5601dfee1ef87a5103a6cc 410 Pfam PF00144 Beta-lactamase 69 400 7.9E-68 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS19675 acd1a74f2f5601dfee1ef87a5103a6cc 410 Gene3D G3DSA:3.40.710.10 59 404 4.2E-77 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS19675 acd1a74f2f5601dfee1ef87a5103a6cc 410 SUPERFAMILY SSF56601 64 382 5.04E-78 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SMART SM00825 Beta-ketoacyl synthase 37 464 3.7E-219 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 573 872 3.7E-101 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1712 1727 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF00698 Acyl transferase domain 572 891 1.0E-79 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 286 5.0E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF51735 1225 1388 2.36E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:3.30.70.250 697 756 3.2E-7 T 17-03-2017 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF08659 KR domain 1401 1579 5.7E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF00550 Phosphopantetheine attachment site 1688 1747 1.6E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF52151 763 858 3.66E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF52151 569 699 3.66E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 411 1.2E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:3.40.47.10 37 298 2.7E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:3.40.50.720 1400 1599 3.2E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 531 2.6E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:3.40.47.10 300 465 6.1E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Pfam PF14765 Polyketide synthase dehydratase 939 1213 3.4E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF47336 1680 1756 1.44E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF51735 1396 1620 1.47E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF53901 34 409 1.97E-97 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:3.40.366.10 761 874 9.0E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:3.40.366.10 568 692 9.0E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1401 1581 1.4E-55 T 17-03-2017 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SMART SM00826 939 1105 2.2E-79 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SUPERFAMILY SSF55048 697 758 7.85E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 Gene3D G3DSA:1.10.1200.10 1684 1756 8.5E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39620 bd9d888de10aaa7fc8205fecea4f8b59 1762 SMART SM00823 Phosphopantetheine attachment site 1685 1757 4.6E-20 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11225 6126569f4a3ee616f61fe9c9e12ddf51 429 SUPERFAMILY SSF53850 27 427 3.6E-43 T 17-03-2017 SHXM_RS11225 6126569f4a3ee616f61fe9c9e12ddf51 429 Pfam PF01547 Bacterial extracellular solute-binding protein 55 346 3.1E-27 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS11225 6126569f4a3ee616f61fe9c9e12ddf51 429 Gene3D G3DSA:3.40.190.10 175 355 2.0E-23 T 17-03-2017 SHXM_RS11225 6126569f4a3ee616f61fe9c9e12ddf51 429 Gene3D G3DSA:3.40.190.10 57 174 2.3E-10 T 17-03-2017 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 Pfam PF13377 Periplasmic binding protein-like domain 167 328 4.1E-39 T 17-03-2017 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 SUPERFAMILY SSF53822 60 330 7.43E-77 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 SUPERFAMILY SSF47413 1 59 3.44E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 Gene3D G3DSA:3.40.50.2300 58 173 2.5E-54 T 17-03-2017 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 Gene3D G3DSA:1.10.260.40 2 57 1.3E-24 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 Gene3D G3DSA:3.40.50.2300 174 308 8.9E-46 T 17-03-2017 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 SMART SM00354 1 71 6.8E-31 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 ProSitePatterns PS00356 LacI-type HTH domain signature. 4 22 - T 17-03-2017 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 Pfam PF00356 Bacterial regulatory proteins, lacI family 3 48 9.3E-18 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 3 13 2.7E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS17960 00f66299345a837cd849fc5eef907d3a 352 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 13 23 2.7E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS45140 628d0f24685fbb66582c81d447dc241e 142 SUPERFAMILY SSF50475 3 138 4.26E-29 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS45140 628d0f24685fbb66582c81d447dc241e 142 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 14 135 1.2E-38 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS45140 628d0f24685fbb66582c81d447dc241e 142 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 12 91 4.8E-17 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS45140 628d0f24685fbb66582c81d447dc241e 142 Gene3D G3DSA:2.30.110.10 4 138 6.3E-39 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 Gene3D G3DSA:1.10.10.10 1 85 4.0E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 SUPERFAMILY SSF46785 1 87 2.72E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 Gene3D G3DSA:3.40.190.10 181 264 3.3E-23 T 17-03-2017 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 Gene3D G3DSA:3.40.190.10 90 180 6.0E-16 T 17-03-2017 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 1.6E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.9E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.9E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.9E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 SUPERFAMILY SSF53850 88 296 1.01E-42 T 17-03-2017 SHXM_RS47865 a4863aac11deb0027864243e3b79b25a 299 Pfam PF03466 LysR substrate binding domain 87 294 1.1E-44 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 SUPERFAMILY SSF46785 2 86 2.17E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 1.1E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 SUPERFAMILY SSF53850 91 295 2.07E-35 T 17-03-2017 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 Gene3D G3DSA:3.40.190.10 179 263 4.0E-24 T 17-03-2017 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 6.2E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 6.2E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 6.2E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 Gene3D G3DSA:3.40.190.10 89 178 1.6E-24 T 17-03-2017 SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 Pfam PF03466 LysR substrate binding domain 88 293 3.4E-42 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS42095 25dda1459ee72858ddfe8a5bbc9e87d4 312 Gene3D G3DSA:1.10.10.10 3 81 5.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF50129 1357 1490 1.73E-26 T 17-03-2017 IPR011032 GroES-like SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM00826 908 1069 1.5E-80 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF51735 1177 1336 2.6E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF00698 Acyl transferase domain 555 860 5.0E-79 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1974 1989 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF55048 678 737 1.24E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF52151 554 679 5.23E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF52151 740 834 5.23E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF08659 KR domain 1668 1847 2.6E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 1485 1506 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.30.70.250 678 731 2.2E-7 T 17-03-2017 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF08990 Erythronolide synthase docking 4 26 4.6E-7 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF51735 1663 1903 1.25E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 190 206 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.50.720 1668 1852 1.5E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.50.720 1933 1945 1.5E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF47336 1942 2025 1.44E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF00107 Zinc-binding dehydrogenase 1496 1587 2.8E-17 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.90.180.10 1370 1490 1.3E-40 T 17-03-2017 IPR011032 GroES-like SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 285 400 1.2E-40 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:1.10.1200.10 1946 2020 6.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF14765 Polyketide synthase dehydratase 908 1172 4.7E-56 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.47.10 290 453 6.8E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM00829 1357 1658 5.8E-164 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF53901 28 390 2.77E-98 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 277 3.2E-82 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SUPERFAMILY SSF51735 1456 1589 3.27E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1668 1848 3.7E-62 T 17-03-2017 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM00825 Beta-ketoacyl synthase 36 453 4.9E-204 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM00823 Phosphopantetheine attachment site 1947 2019 3.7E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.50.720 1491 1585 9.1E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.366.10 738 843 1.1E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.366.10 554 673 1.1E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 557 843 1.3E-114 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1376 1432 1.3E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 403 511 1.8E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Gene3D G3DSA:3.40.47.10 36 289 6.1E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 Pfam PF00550 Phosphopantetheine attachment site 1949 2015 5.7E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46785 7a7847500148bce81785a6436adfc441 2092 SMART SM01294 1948 2015 4.8E-5 T 17-03-2017 SHXM_RS34385 4546a2339ff19907b2bff27ce7cc2f47 981 Hamap MF_01600 UPF0182 protein . 17 893 18.068 T 17-03-2017 IPR005372 Uncharacterised protein family UPF0182 GO:0016021 SHXM_RS34385 4546a2339ff19907b2bff27ce7cc2f47 981 Pfam PF03699 Uncharacterised protein family (UPF0182) 26 813 4.0E-277 T 17-03-2017 IPR005372 Uncharacterised protein family UPF0182 GO:0016021 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Pfam PF03143 Elongation factor Tu C-terminal domain 301 395 2.2E-33 T 17-03-2017 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 SUPERFAMILY SSF50447 207 304 1.02E-30 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Gene3D G3DSA:2.40.30.10 303 395 3.3E-46 T 17-03-2017 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Pfam PF03144 Elongation factor Tu domain 2 227 296 7.4E-17 T 17-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 397 59.392 T 17-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 53 68 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 2 395 1.8E-222 T 17-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Gene3D G3DSA:2.40.30.10 214 301 1.2E-36 T 17-03-2017 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Gene3D G3DSA:3.40.50.300 5 213 3.9E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 SUPERFAMILY SSF52540 6 221 6.59E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 SUPERFAMILY SSF50465 305 397 7.77E-36 T 17-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 PRINTS PR00315 GTP-binding elongation factor signature 133 142 2.3E-24 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 PRINTS PR00315 GTP-binding elongation factor signature 60 68 2.3E-24 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 PRINTS PR00315 GTP-binding elongation factor signature 96 107 2.3E-24 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 PRINTS PR00315 GTP-binding elongation factor signature 14 27 2.3E-24 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 PRINTS PR00315 GTP-binding elongation factor signature 80 90 2.3E-24 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 Pfam PF00009 Elongation factor Tu GTP binding domain 10 203 5.9E-59 T 17-03-2017 SHXM_RS31140 84e697f6ac2bdbc56557933cc99447a7 397 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 13 147 1.9E-13 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS06155 46c38e09908068f9957662a47c8bf5e3 200 TIGRFAM TIGR01323 nitrile_alph: nitrile hydratase, alpha subunit 14 199 5.7E-91 T 17-03-2017 IPR018141 Nitrile hydratase, alpha subunit GO:0006807|GO:0018822|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06155 46c38e09908068f9957662a47c8bf5e3 200 Pfam PF02979 Nitrile hydratase, alpha chain 14 195 6.6E-86 T 17-03-2017 IPR004232 Nitrile hydratase alpha /Thiocyanate hydrolase gamma GO:0003824|GO:0006807|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06155 46c38e09908068f9957662a47c8bf5e3 200 Gene3D G3DSA:3.90.330.10 11 199 5.9E-89 T 17-03-2017 IPR004232 Nitrile hydratase alpha /Thiocyanate hydrolase gamma GO:0003824|GO:0006807|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06155 46c38e09908068f9957662a47c8bf5e3 200 ProDom PD007559 HYDRATASE NITRILE ALPHA SUBUNIT LYASE CHAIN METAL-BINDING DIRECT SEQUENCING NITRILASE 17 193 2.0E-65 T 17-03-2017 IPR004232 Nitrile hydratase alpha /Thiocyanate hydrolase gamma GO:0003824|GO:0006807|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06155 46c38e09908068f9957662a47c8bf5e3 200 PIRSF PIRSF001426 2 200 3.4E-91 T 17-03-2017 IPR023900 Nitrile hydratase alpha subunit /Thiocyanate hydrolase gamma subunit KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06155 46c38e09908068f9957662a47c8bf5e3 200 SUPERFAMILY SSF56209 9 197 3.79E-79 T 17-03-2017 IPR004232 Nitrile hydratase alpha /Thiocyanate hydrolase gamma GO:0003824|GO:0006807|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS23905 08f09999b0b2bebca02033cd17f7b64c 219 Pfam PF13305 WHG domain 107 190 8.2E-12 T 17-03-2017 IPR025996 WHG domain SHXM_RS23905 08f09999b0b2bebca02033cd17f7b64c 219 Gene3D G3DSA:1.10.357.10 16 210 7.0E-37 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS23905 08f09999b0b2bebca02033cd17f7b64c 219 SUPERFAMILY SSF46689 17 99 1.65E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS23905 08f09999b0b2bebca02033cd17f7b64c 219 Pfam PF00440 Bacterial regulatory proteins, tetR family 31 77 1.9E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS23905 08f09999b0b2bebca02033cd17f7b64c 219 SUPERFAMILY SSF48498 103 189 1.81E-14 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS36225 2b4617b01165e4a2827c2382c6343102 543 TIGRFAM TIGR01236 D1pyr5carbox1: 1-pyrroline-5-carboxylate dehydrogenase 12 542 7.4E-244 T 17-03-2017 IPR005931 Delta-1-pyrroline-5-carboxylate dehydrogenase GO:0003842|GO:0006537|GO:0006561 KEGG: 00250+1.2.1.88|KEGG: 00330+1.2.1.88|MetaCyc: PWY-6853|Reactome: R-HSA-70688 SHXM_RS36225 2b4617b01165e4a2827c2382c6343102 543 SUPERFAMILY SSF53720 8 528 1.44E-123 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS36225 2b4617b01165e4a2827c2382c6343102 543 Gene3D G3DSA:3.40.309.10 304 501 4.5E-43 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS36225 2b4617b01165e4a2827c2382c6343102 543 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 321 332 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS36225 2b4617b01165e4a2827c2382c6343102 543 Gene3D G3DSA:3.40.605.10 41 303 3.0E-64 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36225 2b4617b01165e4a2827c2382c6343102 543 Pfam PF00171 Aldehyde dehydrogenase family 55 527 4.3E-104 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS12330 2452a7b53816902f7b61f0d488e51aee 90 SMART SM01409 18 82 2.2E-14 T 17-03-2017 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 SHXM_RS12330 2452a7b53816902f7b61f0d488e51aee 90 Gene3D G3DSA:3.90.940.10 11 85 5.3E-34 T 17-03-2017 IPR012293 RNA polymerase subunit, RPB6/omega GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 SHXM_RS12330 2452a7b53816902f7b61f0d488e51aee 90 Hamap MF_00366 DNA-directed RNA polymerase subunit omega [rpoZ]. 11 83 14.945 T 17-03-2017 IPR003716 DNA-directed RNA polymerase, omega subunit GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS12330 2452a7b53816902f7b61f0d488e51aee 90 TIGRFAM TIGR00690 rpoZ: DNA-directed RNA polymerase, omega subunit 12 80 8.5E-22 T 17-03-2017 IPR003716 DNA-directed RNA polymerase, omega subunit GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS12330 2452a7b53816902f7b61f0d488e51aee 90 SUPERFAMILY SSF63562 11 86 1.06E-24 T 17-03-2017 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 SHXM_RS12330 2452a7b53816902f7b61f0d488e51aee 90 Pfam PF01192 RNA polymerase Rpb6 18 80 9.7E-15 T 17-03-2017 IPR006110 RNA polymerase, subunit omega/K/RPB6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6|Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-168325|Reactome: R-HSA-1834949|Reactome: R-HSA-203927|Reactome: R-HSA-427413|Reactome: R-HSA-452723|Reactome: R-HSA-5250924|Reactome: R-HSA-5578749|Reactome: R-HSA-5601884|Reactome: R-HSA-5617472|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-6803529|Reactome: R-HSA-6807505|Reactome: R-HSA-72086|Reactome: R-HSA-72163|Reactome: R-HSA-72165|Reactome: R-HSA-72203|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73780|Reactome: R-HSA-73863|Reactome: R-HSA-73980|Reactome: R-HSA-749476|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-76061|Reactome: R-HSA-76066|Reactome: R-HSA-76071|Reactome: R-HSA-77075|Reactome: R-HSA-8851708 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 422 517 9.0E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Pfam PF00155 Aminotransferase class I and II 806 1145 3.2E-41 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Gene3D G3DSA:3.40.640.10 823 1039 6.0E-79 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Gene3D G3DSA:3.90.1150.10 1040 1150 6.1E-21 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 SUPERFAMILY SSF53383 785 1151 4.89E-98 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 19 293 1.4E-61 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 SUPERFAMILY SSF47336 675 754 3.17E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 SUPERFAMILY SSF53901 17 138 1.18E-72 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 SUPERFAMILY SSF53901 442 461 1.18E-72 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 SUPERFAMILY SSF53901 189 411 1.18E-72 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Gene3D G3DSA:3.40.47.10 306 465 3.4E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Gene3D G3DSA:3.40.47.10 17 305 1.0E-72 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 SMART SM00825 Beta-ketoacyl synthase 21 465 2.9E-97 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS11165 0f26dab610edea2fb3af44c365e2575d 1158 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 301 415 9.8E-33 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 Pfam PF00107 Zinc-binding dehydrogenase 190 319 4.8E-26 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 SUPERFAMILY SSF51735 154 324 3.08E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 SMART SM00829 14 361 2.9E-5 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 SUPERFAMILY SSF50129 4 186 2.04E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 147 3.0E-26 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 Gene3D G3DSA:3.40.50.720 183 302 3.6E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 Gene3D G3DSA:3.90.180.10 1 182 9.9E-57 T 17-03-2017 IPR011032 GroES-like SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 TIGRFAM TIGR03451 mycoS_dep_FDH: S-(hydroxymethyl)mycothiol dehydrogenase 5 361 2.6E-196 T 17-03-2017 IPR017816 S-(hydroxymethyl)mycothiol dehydrogenase KEGG: 00072+1.1.1.30|KEGG: 00650+1.1.1.30 SHXM_RS43765 2984a3b514c6f9121570975c7aadf9e7 361 SUPERFAMILY SSF50129 310 360 1.98E-6 T 17-03-2017 IPR011032 GroES-like SHXM_RS02565 2b5d5de4c7355a4d599aca4a32a78ab0 285 Gene3D G3DSA:3.40.50.150 63 197 5.0E-15 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02565 2b5d5de4c7355a4d599aca4a32a78ab0 285 TIGRFAM TIGR00027 mthyl_TIGR00027: methyltransferase, TIGR00027 family 11 265 1.2E-47 T 17-03-2017 IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative GO:0008168 SHXM_RS02565 2b5d5de4c7355a4d599aca4a32a78ab0 285 SUPERFAMILY SSF53335 10 281 1.07E-62 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02565 2b5d5de4c7355a4d599aca4a32a78ab0 285 Pfam PF04072 Leucine carboxyl methyltransferase 13 190 1.2E-48 T 17-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 SHXM_RS37280 b23267e3811c7bc96e88982ca68a13f5 258 Pfam PF00005 ABC transporter 33 181 1.8E-36 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS37280 b23267e3811c7bc96e88982ca68a13f5 258 ProSitePatterns PS00211 ABC transporters family signature. 153 167 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS37280 b23267e3811c7bc96e88982ca68a13f5 258 SMART SM00382 42 229 2.5E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37280 b23267e3811c7bc96e88982ca68a13f5 258 SUPERFAMILY SSF52540 18 251 6.56E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37280 b23267e3811c7bc96e88982ca68a13f5 258 Gene3D G3DSA:3.40.50.300 17 253 2.6E-84 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37280 b23267e3811c7bc96e88982ca68a13f5 258 PIRSF PIRSF039085 14 257 1.2E-113 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 SUPERFAMILY SSF52283 24 127 7.65E-10 T 17-03-2017 SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 24 318 5.2E-8 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 SUPERFAMILY SSF51735 100 288 4.63E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 198 220 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 Gene3D G3DSA:3.40.50.720 115 289 2.3E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 Gene3D G3DSA:3.40.50.720 35 114 1.2E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50465 438ae7f3548484e0eff5923877fde145 327 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 135 287 1.8E-43 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 1.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 44 67 1.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 Pfam PF14246 AefR-like transcriptional repressor, C-terminal region 159 212 1.3E-14 T 17-03-2017 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 Gene3D G3DSA:1.10.10.60 12 65 1.0E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 SUPERFAMILY SSF48498 92 210 2.14E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 Gene3D G3DSA:1.10.357.10 66 216 1.7E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 SUPERFAMILY SSF46689 12 88 4.62E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03835 2ba727169345b4b4655985b610acb3be 220 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 68 4.9E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 Hamap MF_00173 Arginine repressor [argR]. 1 187 53.6 T 17-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 Pfam PF01316 Arginine repressor, DNA binding domain 27 94 4.3E-25 T 17-03-2017 IPR020900 Arginine repressor, DNA-binding domain GO:0003700|GO:0006355|GO:0006525 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 SUPERFAMILY SSF55252 117 182 1.57E-18 T 17-03-2017 IPR020899 Arginine repressor, C-terminal GO:0034618|GO:0051259 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 PRINTS PR01467 Bacterial arginine repressor signature 123 136 2.7E-26 T 17-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 PRINTS PR01467 Bacterial arginine repressor signature 153 168 2.7E-26 T 17-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 PRINTS PR01467 Bacterial arginine repressor signature 46 59 2.7E-26 T 17-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 PRINTS PR01467 Bacterial arginine repressor signature 62 77 2.7E-26 T 17-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 Gene3D G3DSA:3.30.1360.40 108 183 5.0E-28 T 17-03-2017 IPR024946 Arginine repressor C-terminal-like domain SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 ProDom PD007402 ARGININE REPRESSOR TRANSCRIPTION BIOSYNTHESIS DNA-BINDING REGULATION AMINO-ACID ARGR TRANSCRIPTIONAL FAMILY 129 162 3.0E-11 T 17-03-2017 IPR020899 Arginine repressor, C-terminal GO:0034618|GO:0051259 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 SUPERFAMILY SSF46785 26 94 2.36E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 Gene3D G3DSA:1.10.10.10 24 97 2.0E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 TIGRFAM TIGR01529 argR_whole: arginine repressor 30 183 9.5E-44 T 17-03-2017 IPR001669 Arginine repressor GO:0003700|GO:0006355 SHXM_RS12975 11e8cc29183e5101dd3f76933b18aadf 188 Pfam PF02863 Arginine repressor, C-terminal domain 116 180 1.5E-23 T 17-03-2017 IPR020899 Arginine repressor, C-terminal GO:0034618|GO:0051259 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 Gene3D G3DSA:3.40.190.10 182 268 2.1E-26 T 17-03-2017 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 Pfam PF03466 LysR substrate binding domain 89 292 5.4E-47 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 SUPERFAMILY SSF46785 3 112 1.73E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 Gene3D G3DSA:1.10.10.10 2 80 1.5E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 SUPERFAMILY SSF53850 90 294 1.01E-44 T 17-03-2017 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 Gene3D G3DSA:3.40.190.10 90 181 1.7E-22 T 17-03-2017 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 6.0E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 1.9E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 1.9E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS07600 8a7ef78edfb758a36ddb044ba3cc30b8 314 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 1.9E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS47280 adc7984bfedd42385bc5ad61fcfd4f60 444 Pfam PF07690 Major Facilitator Superfamily 269 433 3.1E-13 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS47280 adc7984bfedd42385bc5ad61fcfd4f60 444 SUPERFAMILY SSF103473 29 435 1.31E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47280 adc7984bfedd42385bc5ad61fcfd4f60 444 Gene3D G3DSA:1.20.1250.20 256 437 1.2E-20 T 17-03-2017 SHXM_RS47280 adc7984bfedd42385bc5ad61fcfd4f60 444 Gene3D G3DSA:1.20.1250.20 30 226 7.1E-22 T 17-03-2017 SHXM_RS47280 adc7984bfedd42385bc5ad61fcfd4f60 444 Pfam PF00083 Sugar (and other) transporter 32 247 1.5E-21 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS47280 adc7984bfedd42385bc5ad61fcfd4f60 444 ProSitePatterns PS00217 Sugar transport proteins signature 2. 141 166 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS24575 3c81d201188dfa9ff77c7a1e9af817e8 133 SUPERFAMILY SSF103196 3 126 9.42E-26 T 17-03-2017 SHXM_RS24575 3c81d201188dfa9ff77c7a1e9af817e8 133 SMART SM00960 6 97 1.5E-20 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS24575 3c81d201188dfa9ff77c7a1e9af817e8 133 Pfam PF03259 Roadblock/LC7 domain 9 96 3.5E-23 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS24575 3c81d201188dfa9ff77c7a1e9af817e8 133 Gene3D G3DSA:3.30.450.30 3 124 4.0E-26 T 17-03-2017 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00028 833 866 290.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00028 873 906 6.2 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00028 753 786 17.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00028 913 946 24.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00028 793 826 370.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SUPERFAMILY SSF46894 16 105 3.97E-11 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM01043 112 256 2.0E-48 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 PRINTS PR00364 Disease resistance protein signature 330 345 2.5E-11 T 17-03-2017 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 PRINTS PR00364 Disease resistance protein signature 408 422 2.5E-11 T 17-03-2017 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 PRINTS PR00364 Disease resistance protein signature 493 507 2.5E-11 T 17-03-2017 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SUPERFAMILY SSF48452 833 947 4.17E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SUPERFAMILY SSF48452 699 859 3.64E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Pfam PF00931 NB-ARC domain 325 556 6.8E-18 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00862 30 105 8.1E-4 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SUPERFAMILY SSF48452 108 275 1.83E-32 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Pfam PF03704 Bacterial transcriptional activator domain 112 256 1.9E-44 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Gene3D G3DSA:3.40.50.300 343 491 7.0E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Gene3D G3DSA:1.25.40.10 697 862 3.3E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Gene3D G3DSA:3.40.50.300 302 342 5.6E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Pfam PF13424 Tetratricopeptide repeat 753 821 1.3E-10 T 17-03-2017 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Gene3D G3DSA:1.25.40.10 872 944 1.6E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SUPERFAMILY SSF52540 297 559 1.53E-30 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Gene3D G3DSA:1.10.10.10 42 108 6.8E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 SMART SM00382 327 607 3.1E-5 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS39150 2241b86bd98846758ba511a62c34c8bd 971 Pfam PF00486 Transcriptional regulatory protein, C terminal 42 105 8.7E-7 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 SUPERFAMILY SSF55347 130 295 4.71E-17 T 17-03-2017 SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 138 237 5.5E-6 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 3 123 5.4E-27 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 Hamap MF_01671 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase [iolG]. 1 336 50.215 T 17-03-2017 IPR023794 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase GO:0019310|GO:0050112|GO:0055114 KEGG: 00521+1.1.1.18|KEGG: 00562+1.1.1.18|MetaCyc: PWY-5940|MetaCyc: PWY-7237|MetaCyc: PWY-7241 SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 Gene3D G3DSA:3.40.50.720 3 149 6.0E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 SUPERFAMILY SSF51735 3 152 1.17E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02995 829304481ae0c9a14aad2c125749adf4 339 Gene3D G3DSA:3.30.360.10 150 261 1.4E-38 T 17-03-2017 SHXM_RS33260 4476d34b007b2a9f67785e4db550c65e 226 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 52 75 6.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33260 4476d34b007b2a9f67785e4db550c65e 226 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 31 44 6.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33260 4476d34b007b2a9f67785e4db550c65e 226 Gene3D G3DSA:1.10.357.10 73 225 8.1E-33 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS33260 4476d34b007b2a9f67785e4db550c65e 226 Gene3D G3DSA:1.10.10.60 20 72 7.8E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS33260 4476d34b007b2a9f67785e4db550c65e 226 SUPERFAMILY SSF46689 18 76 8.98E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS33260 4476d34b007b2a9f67785e4db550c65e 226 Pfam PF00440 Bacterial regulatory proteins, tetR family 31 75 2.0E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39185 43511ecee171b1ff2e4e5c983d909f4d 348 Pfam PF01548 Transposase 4 157 1.4E-21 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS39185 43511ecee171b1ff2e4e5c983d909f4d 348 Pfam PF02371 Transposase IS116/IS110/IS902 family 221 305 3.7E-21 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 Gene3D G3DSA:3.40.50.2300 162 323 2.4E-51 T 17-03-2017 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 Gene3D G3DSA:1.10.260.40 1 56 2.8E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 45 7.0E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 SUPERFAMILY SSF53822 66 327 4.28E-53 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 SUPERFAMILY SSF47413 1 56 5.12E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 SMART SM00354 1 68 1.2E-10 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 Gene3D G3DSA:3.40.50.2300 72 161 5.6E-11 T 17-03-2017 SHXM_RS11340 2670f8a37e98b551000010e29ca00f99 336 Pfam PF13377 Periplasmic binding protein-like domain 162 321 5.2E-38 T 17-03-2017 SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 Pfam PF00440 Bacterial regulatory proteins, tetR family 33 79 4.8E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 SUPERFAMILY SSF46689 21 95 3.28E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 SUPERFAMILY SSF48498 99 208 8.45E-31 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 46 2.0E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 54 77 2.0E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 Gene3D G3DSA:1.10.357.10 82 208 4.4E-43 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS30335 7098ef1442dd5e185d347ebdcc9db272 209 Gene3D G3DSA:1.10.10.60 20 79 4.9E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22005 cac053d66bf9c2c0a639e5683b3bb412 465 Pfam PF05506 Domain of unknown function (DUF756) 318 388 1.9E-8 T 17-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SHXM_RS22005 cac053d66bf9c2c0a639e5683b3bb412 465 TIGRFAM TIGR03934 TQXA_dom: TQXA domain 119 166 4.4E-16 T 17-03-2017 IPR023849 Uncharacterised domain CHP03934, TQXA SHXM_RS22005 cac053d66bf9c2c0a639e5683b3bb412 465 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 426 460 2.7E-5 T 17-03-2017 IPR019931 LPXTG cell wall anchor domain SHXM_RS00595 44cfa7492cfe5966c8298a5a92a53d81 1012 Pfam PF13700 Domain of unknown function (DUF4158) 4 154 3.9E-28 T 17-03-2017 IPR025296 Domain of unknown function DUF4158 SHXM_RS00595 44cfa7492cfe5966c8298a5a92a53d81 1012 Pfam PF01526 Tn3 transposase DDE domain 588 978 2.1E-131 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 Pfam PF08533 Beta-galactosidase C-terminal domain 609 660 7.9E-8 T 17-03-2017 IPR013739 Beta-galactosidase C-terminal GO:0004565|GO:0006012 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 SUPERFAMILY SSF52317 391 599 5.65E-48 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 Gene3D G3DSA:3.40.50.880 391 602 8.6E-63 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 Gene3D G3DSA:3.20.20.80 14 386 6.6E-132 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 Pfam PF08532 Beta-galactosidase trimerisation domain 393 599 3.5E-58 T 17-03-2017 IPR013738 Beta-galactosidase trimerisation GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 Pfam PF02449 Beta-galactosidase 17 382 2.2E-146 T 17-03-2017 IPR013529 Glycoside hydrolase, family 42, N-terminal GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 SUPERFAMILY SSF51445 7 364 2.92E-114 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS36845 5a301f7e2ca8b3c893c6c95c1ada0a72 686 PIRSF PIRSF001084 4 662 1.8E-251 T 17-03-2017 IPR003476 Glycoside hydrolase, family 42 GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PIRSF PIRSF001415 2 333 1.7E-141 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 Gene3D G3DSA:3.20.20.70 7 332 5.6E-140 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 SUPERFAMILY SSF51569 6 332 1.05E-128 T 17-03-2017 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 ProSitePatterns PS00169 Delta-aminolevulinic acid dehydratase active site. 249 261 - T 17-03-2017 IPR030656 Delta-aminolevulinic acid dehydratase, active site KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 304 323 5.3E-53 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 129 143 5.3E-53 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 274 289 5.3E-53 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 198 217 5.3E-53 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 249 265 5.3E-53 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 PRINTS PR00144 Delta-aminolevulinic acid dehydratase signature 160 179 5.3E-53 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 SMART SM01004 8 330 3.9E-205 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30475 504f08d8452c2876e5eaecda9b5bb381 334 Pfam PF00490 Delta-aminolevulinic acid dehydratase 11 328 5.2E-135 T 17-03-2017 IPR001731 Delta-aminolevulinic acid dehydratase GO:0004655|GO:0033014|GO:0046872 KEGG: 00860+4.2.1.24|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS44150 fdb81c1601f252a4c27a8ea411aed3a6 470 SMART SM00100 95 218 6.1E-18 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS44150 fdb81c1601f252a4c27a8ea411aed3a6 470 SUPERFAMILY SSF51206 90 222 5.11E-22 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS44150 fdb81c1601f252a4c27a8ea411aed3a6 470 Pfam PF00027 Cyclic nucleotide-binding domain 115 201 2.1E-15 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS44150 fdb81c1601f252a4c27a8ea411aed3a6 470 Gene3D G3DSA:2.60.120.10 92 214 7.8E-21 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 SUPERFAMILY SSF56059 536 747 1.8E-39 T 17-03-2017 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 SUPERFAMILY SSF52210 346 503 4.45E-24 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 SUPERFAMILY SSF52210 200 342 1.96E-32 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 Gene3D G3DSA:3.30.470.20 540 581 1.5E-5 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 SUPERFAMILY SSF51735 61 189 4.63E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 Gene3D G3DSA:3.40.50.261 186 338 3.4E-16 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 SMART SM00881 64 159 6.4E-16 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 Gene3D G3DSA:3.40.50.720 58 185 5.4E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 Pfam PF13380 CoA binding domain 69 189 3.0E-14 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 Pfam PF13549 ATP-grasp domain 533 744 4.9E-62 T 17-03-2017 SHXM_RS31730 f019f11d400111add1472f2fed957f6f 749 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 206 340 1.1E-43 T 17-03-2017 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 SUPERFAMILY SSF49785 77 242 3.06E-11 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 SMART SM00813 493 846 6.8E-53 T 17-03-2017 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55 SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 SUPERFAMILY SSF51445 223 569 2.32E-66 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 SUPERFAMILY SSF49899 668 753 2.74E-7 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 Gene3D G3DSA:2.60.120.260 78 240 2.1E-15 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 Pfam PF02018 Carbohydrate binding domain 77 227 1.9E-10 T 17-03-2017 IPR003305 Carbohydrate-binding, CenC-like GO:0016798 SHXM_RS04535 4384a4c15cbc3005fe5c5b5cdfd82770 856 Pfam PF06964 Alpha-L-arabinofuranosidase C-terminal domain 493 846 2.2E-38 T 17-03-2017 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 Gene3D G3DSA:3.40.190.10 105 172 4.0E-19 T 17-03-2017 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 SUPERFAMILY SSF53850 103 281 6.79E-27 T 17-03-2017 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 64 1.0E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 1.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 1.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 1.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 Pfam PF03466 LysR substrate binding domain 104 278 4.0E-29 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 Gene3D G3DSA:3.40.190.10 173 251 4.2E-15 T 17-03-2017 SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 SUPERFAMILY SSF46785 3 83 8.7E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38565 4f50e73a9fb744c534a0b536651fd131 303 Gene3D G3DSA:1.10.10.10 2 84 1.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 SMART SM00491 498 627 6.1E-41 T 17-03-2017 IPR006555 ATP-dependent helicase, C-terminal GO:0003676|GO:0005524|GO:0006139|GO:0008026|GO:0016818 SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 Gene3D G3DSA:3.40.50.300 471 623 9.4E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 Gene3D G3DSA:3.40.50.300 29 86 3.1E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 Gene3D G3DSA:3.40.50.300 194 262 3.1E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 Gene3D G3DSA:3.40.50.300 128 129 3.1E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 Gene3D G3DSA:3.40.50.300 399 408 3.1E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 Pfam PF13307 Helicase C-terminal domain 481 639 3.0E-27 T 17-03-2017 IPR006555 ATP-dependent helicase, C-terminal GO:0003676|GO:0005524|GO:0006139|GO:0008026|GO:0016818 SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 SMART SM00487 20 293 1.1E-4 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 SUPERFAMILY SSF52540 455 619 2.6E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 SUPERFAMILY SSF52540 194 265 2.6E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 SUPERFAMILY SSF52540 397 411 2.6E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37380 02b498ce1ac185a4619bc7301166a34c 666 SUPERFAMILY SSF52540 39 88 2.6E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31340 c07b90e3e92e494a5f363630a5d2a229 339 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 176 333 2.3E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS31340 c07b90e3e92e494a5f363630a5d2a229 339 Gene3D G3DSA:3.30.565.10 12 125 7.4E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS31340 c07b90e3e92e494a5f363630a5d2a229 339 SUPERFAMILY SSF81606 149 333 2.88E-12 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS31340 c07b90e3e92e494a5f363630a5d2a229 339 SMART SM00331 146 334 9.8E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS31340 c07b90e3e92e494a5f363630a5d2a229 339 SUPERFAMILY SSF55874 32 125 3.01E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS02260 4e0414dfa004a45af8407219038088d4 284 SUPERFAMILY SSF56281 36 250 1.17E-36 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02260 4e0414dfa004a45af8407219038088d4 284 Pfam PF00753 Metallo-beta-lactamase superfamily 45 210 2.7E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02260 4e0414dfa004a45af8407219038088d4 284 Gene3D G3DSA:3.60.15.10 42 247 7.0E-35 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02260 4e0414dfa004a45af8407219038088d4 284 SMART SM00849 42 242 3.6E-12 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41615 325fb03e746fda1e2a879dcb896217c8 154 TIGRFAM TIGR00689 rpiB_lacA_lacB: sugar-phosphate isomerase, RpiB/LacA/LacB family 9 153 2.1E-33 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS41615 325fb03e746fda1e2a879dcb896217c8 154 PIRSF PIRSF005384 7 154 6.7E-45 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS41615 325fb03e746fda1e2a879dcb896217c8 154 Gene3D G3DSA:3.40.1400.10 7 153 4.1E-48 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS41615 325fb03e746fda1e2a879dcb896217c8 154 TIGRFAM TIGR02133 RPI_actino: ribose 5-phosphate isomerase 8 153 6.6E-60 T 17-03-2017 IPR011860 Ribose 5-phosphate isomerase GO:0004751 SHXM_RS41615 325fb03e746fda1e2a879dcb896217c8 154 SUPERFAMILY SSF89623 6 153 1.57E-46 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS41615 325fb03e746fda1e2a879dcb896217c8 154 Pfam PF02502 Ribose/Galactose Isomerase 9 149 7.5E-44 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 Pfam PF00005 ABC transporter 40 190 8.8E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 242 271 6.1E-7 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 305 336 2.2E-5 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 SMART SM00382 48 240 3.6E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 ProSitePatterns PS00211 ABC transporters family signature. 163 177 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 Gene3D G3DSA:3.40.50.300 10 264 2.0E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 SUPERFAMILY SSF52540 29 261 9.63E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33945 1253ae72f4b4fb947c34f319de07afda 393 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 302 359 5.4E-14 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 132 160 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 181 0.001 T 17-03-2017 SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 Gene3D G3DSA:3.40.50.720 5 229 6.6E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 SUPERFAMILY SSF51735 1 228 2.12E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 135 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 183 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 164 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07580 29a5854aa2571cb859a1d76f007f13c7 263 Pfam PF00106 short chain dehydrogenase 7 185 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 Gene3D G3DSA:3.40.50.2300 54 170 5.3E-36 T 17-03-2017 SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 SUPERFAMILY SSF47413 2 58 1.43E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 SMART SM00354 1 71 3.4E-29 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 Pfam PF13377 Periplasmic binding protein-like domain 167 327 3.2E-37 T 17-03-2017 SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 48 3.5E-20 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 Gene3D G3DSA:1.10.260.40 2 53 4.4E-26 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 SUPERFAMILY SSF53822 61 330 2.36E-75 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS42080 17624ac89870b2ae2637d0df7977492b 333 Gene3D G3DSA:3.40.50.2300 171 308 6.5E-51 T 17-03-2017 SHXM_RS37415 7a64ab783dc385a6d7975e309f983727 219 Gene3D G3DSA:3.40.50.1240 4 193 2.2E-45 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS37415 7a64ab783dc385a6d7975e309f983727 219 SMART SM00855 6 166 3.0E-18 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS37415 7a64ab783dc385a6d7975e309f983727 219 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 7 185 9.7E-36 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS37415 7a64ab783dc385a6d7975e309f983727 219 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 9 18 - T 17-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 SHXM_RS37415 7a64ab783dc385a6d7975e309f983727 219 SUPERFAMILY SSF53254 4 199 4.45E-40 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 Gene3D G3DSA:3.40.50.300 1 212 9.9E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 Pfam PF05191 Adenylate kinase, active site lid 127 163 3.9E-13 T 17-03-2017 IPR007862 Adenylate kinase, active site lid domain GO:0004017 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 Hamap MF_00235 Adenylate kinase [adk]. 1 214 51.066 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 SUPERFAMILY SSF52540 1 215 4.22E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 Pfam PF00406 Adenylate kinase 5 191 1.1E-57 T 17-03-2017 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 ProSitePatterns PS00113 Adenylate kinase signature. 81 92 - T 17-03-2017 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 TIGRFAM TIGR01351 adk: adenylate kinase 2 213 1.6E-77 T 17-03-2017 IPR006259 Adenylate kinase subfamily GO:0004017|GO:0005524|GO:0016776 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 PRINTS PR00094 Adenylate kinase signature 81 97 1.1E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 PRINTS PR00094 Adenylate kinase signature 32 46 1.1E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 PRINTS PR00094 Adenylate kinase signature 4 17 1.1E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 PRINTS PR00094 Adenylate kinase signature 178 192 1.1E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS31275 587fbd23f05e31fa3d675194ec9b0800 218 PRINTS PR00094 Adenylate kinase signature 161 176 1.1E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS43855 1c19ea5faf2436108e1934c1b76ac9b4 812 Pfam PF01055 Glycosyl hydrolases family 31 286 727 3.0E-125 T 17-03-2017 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 SHXM_RS43855 1c19ea5faf2436108e1934c1b76ac9b4 812 SUPERFAMILY SSF51011 643 722 8.63E-20 T 17-03-2017 SHXM_RS43855 1c19ea5faf2436108e1934c1b76ac9b4 812 Pfam PF13802 Galactose mutarotase-like 188 253 1.0E-10 T 17-03-2017 IPR025887 Glycoside hydrolase family 31, N-terminal domain SHXM_RS43855 1c19ea5faf2436108e1934c1b76ac9b4 812 ProSitePatterns PS00129 Glycosyl hydrolases family 31 active site. 454 461 - T 17-03-2017 IPR030458 Glycosyl hydrolases family 31, active site SHXM_RS43855 1c19ea5faf2436108e1934c1b76ac9b4 812 SUPERFAMILY SSF51445 294 641 1.32E-79 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS43855 1c19ea5faf2436108e1934c1b76ac9b4 812 SUPERFAMILY SSF74650 73 289 2.86E-16 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 SUPERFAMILY SSF51445 51 350 4.21E-57 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 Pfam PF16499 Alpha galactosidase A 73 398 7.7E-53 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 SUPERFAMILY SSF89372 451 707 1.96E-31 T 17-03-2017 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 Gene3D G3DSA:3.20.20.70 51 343 5.5E-80 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 PRINTS PR00740 Glycosyl hydrolase family 27 signature 87 102 6.0E-23 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 PRINTS PR00740 Glycosyl hydrolase family 27 signature 165 182 6.0E-23 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 PRINTS PR00740 Glycosyl hydrolase family 27 signature 52 71 6.0E-23 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 PRINTS PR00740 Glycosyl hydrolase family 27 signature 129 150 6.0E-23 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 PRINTS PR00740 Glycosyl hydrolase family 27 signature 194 212 6.0E-23 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 PRINTS PR00740 Glycosyl hydrolase family 27 signature 305 326 6.0E-23 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 Gene3D G3DSA:2.120.10.70 454 564 4.4E-20 T 17-03-2017 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 Gene3D G3DSA:2.120.10.70 610 706 4.4E-20 T 17-03-2017 SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 Gene3D G3DSA:2.60.40.1180 344 438 8.4E-23 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS38050 07eebaff8e5908d82878a440dc8d592e 709 SUPERFAMILY SSF51011 351 437 8.8E-14 T 17-03-2017 SHXM_RS34945 47965678b155fddf4a5ce9fed3d72f56 229 SUPERFAMILY SSF48498 80 178 2.67E-5 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS34945 47965678b155fddf4a5ce9fed3d72f56 229 Pfam PF00440 Bacterial regulatory proteins, tetR family 10 57 4.0E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34945 47965678b155fddf4a5ce9fed3d72f56 229 Gene3D G3DSA:1.10.357.10 4 197 3.1E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34945 47965678b155fddf4a5ce9fed3d72f56 229 SUPERFAMILY SSF46689 5 67 1.16E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 Gene3D G3DSA:3.40.50.720 257 439 1.6E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 257 436 1.4E-51 T 17-03-2017 SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 SMART SM00823 Phosphopantetheine attachment site 545 617 1.9E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 ProSitePatterns PS00012 Phosphopantetheine attachment site. 572 587 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 Gene3D G3DSA:1.10.1200.10 543 617 7.9E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 Pfam PF08659 KR domain 257 434 6.9E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 SUPERFAMILY SSF47336 538 623 3.8E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 SMART SM01294 546 613 2.8E-7 T 17-03-2017 SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 SUPERFAMILY SSF51735 41 242 3.03E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 Pfam PF00550 Phosphopantetheine attachment site 547 613 3.0E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38780 6a9b3c1a277d37abb791228c77f7b4f7 712 SUPERFAMILY SSF51735 257 497 2.14E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32120 bfb9bd3dd880da768701f3d36c9748eb 384 Gene3D G3DSA:3.40.640.10 37 241 2.1E-58 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS32120 bfb9bd3dd880da768701f3d36c9748eb 384 Pfam PF00155 Aminotransferase class I and II 56 367 2.5E-50 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS32120 bfb9bd3dd880da768701f3d36c9748eb 384 Gene3D G3DSA:3.90.1150.10 242 372 1.5E-23 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS32120 bfb9bd3dd880da768701f3d36c9748eb 384 SUPERFAMILY SSF53383 30 371 2.13E-84 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS32670 dc06e1f76577f8b0de81b6361a78b7aa 306 Gene3D G3DSA:3.20.20.140 26 305 1.1E-79 T 17-03-2017 SHXM_RS32670 dc06e1f76577f8b0de81b6361a78b7aa 306 Pfam PF01026 TatD related DNase 37 304 1.1E-68 T 17-03-2017 IPR001130 TatD family GO:0016788 SHXM_RS32670 dc06e1f76577f8b0de81b6361a78b7aa 306 PIRSF PIRSF005902 26 306 3.1E-69 T 17-03-2017 IPR001130 TatD family GO:0016788 SHXM_RS32670 dc06e1f76577f8b0de81b6361a78b7aa 306 SUPERFAMILY SSF51556 34 305 2.62E-73 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS23235 eac1c97ab255fc032d306a72054c16af 196 Pfam PF04862 Protein of unknown function (DUF642) 33 187 4.8E-30 T 17-03-2017 IPR006946 Domain of unknown function DUF642 SHXM_RS23235 eac1c97ab255fc032d306a72054c16af 196 TIGRFAM TIGR04362 choice_anch_C: choice-of-anchor C domain 33 186 2.5E-47 T 17-03-2017 IPR027576 Choice-of-anchor C domain SHXM_RS40330 df4be7f4a2ded9053e8edadaf6ea7cef 146 SUPERFAMILY SSF54593 3 143 6.88E-31 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS40330 df4be7f4a2ded9053e8edadaf6ea7cef 146 Gene3D G3DSA:3.10.180.10 1 144 2.2E-50 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS40330 df4be7f4a2ded9053e8edadaf6ea7cef 146 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 118 1.4E-10 T 17-03-2017 SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 Gene3D G3DSA:3.90.1150.10 337 427 7.0E-38 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 Gene3D G3DSA:3.90.1150.10 31 87 7.0E-38 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 SUPERFAMILY SSF53383 32 427 2.58E-115 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 Gene3D G3DSA:3.40.640.10 88 333 3.9E-79 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 Pfam PF00202 Aminotransferase class-III 45 427 1.0E-107 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 TIGRFAM TIGR01885 Orn_aminotrans: ornithine--oxo-acid transaminase 34 427 2.9E-146 T 17-03-2017 IPR010164 Ornithine aminotransferase GO:0008483|GO:0030170 KEGG: 00330+2.6.1.13|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS06655 fa7b60dab2b0b5d80c01187b8463d9f5 428 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 252 289 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS09690 5396fab463444fb6443feaf2c49a253e 178 SMART SM00960 46 139 2.2E-5 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS09690 5396fab463444fb6443feaf2c49a253e 178 Pfam PF03259 Roadblock/LC7 domain 49 130 5.5E-10 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS09690 5396fab463444fb6443feaf2c49a253e 178 SUPERFAMILY SSF103196 41 142 1.99E-11 T 17-03-2017 SHXM_RS09690 5396fab463444fb6443feaf2c49a253e 178 Gene3D G3DSA:3.30.450.30 40 143 7.2E-10 T 17-03-2017 SHXM_RS05535 709a7c08b13ca74e1d09574631f1c4db 184 SUPERFAMILY SSF48498 78 181 1.93E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS05535 709a7c08b13ca74e1d09574631f1c4db 184 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 6.8E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05535 709a7c08b13ca74e1d09574631f1c4db 184 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 6.8E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05535 709a7c08b13ca74e1d09574631f1c4db 184 SUPERFAMILY SSF46689 7 82 2.36E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05535 709a7c08b13ca74e1d09574631f1c4db 184 Gene3D G3DSA:1.10.357.10 10 181 3.1E-30 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS05535 709a7c08b13ca74e1d09574631f1c4db 184 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 56 3.7E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 Pfam PF13538 UvrD-like helicase C-terminal domain 410 457 1.7E-16 T 17-03-2017 IPR027785 UvrD-like helicase C-terminal domain SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 SUPERFAMILY SSF52540 200 266 5.32E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 SUPERFAMILY SSF52540 305 477 5.32E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 Pfam PF13604 AAA domain 89 265 1.3E-44 T 17-03-2017 SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 SUPERFAMILY SSF52540 85 247 4.21E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 Gene3D G3DSA:3.40.50.300 412 487 3.1E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49280 a8602065ed5bfa7690012510567fbfd5 509 Gene3D G3DSA:3.40.50.300 53 254 5.3E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 Gene3D G3DSA:3.40.50.720 1 165 3.8E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 Pfam PF02056 Family 4 glycosyl hydrolase 6 181 1.5E-43 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 ProSitePatterns PS01324 Glycosyl hydrolases family 4 signature. 137 167 - T 17-03-2017 IPR019802 Glycoside hydrolase, family 4, conserved site GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 192 431 6.7E-43 T 17-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 162 173 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 73 89 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 137 154 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 94 107 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 2 17 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 108 128 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 PRINTS PR00732 Glycosyl hydrolase family 4 signature 188 200 5.2E-38 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 Gene3D G3DSA:3.90.110.10 166 443 8.4E-94 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 SUPERFAMILY SSF51735 1 165 1.47E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07755 946e018619316e65936c0547dc7f12d4 450 SUPERFAMILY SSF56327 166 442 1.81E-58 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 Pfam PF08281 Sigma-70, region 4 104 154 8.7E-13 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 Gene3D G3DSA:3.10.450.50 167 285 9.1E-15 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 Gene3D G3DSA:1.10.10.10 99 158 1.2E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 158 3.7E-17 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 Gene3D G3DSA:1.10.1740.10 7 72 1.0E-10 T 17-03-2017 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 SUPERFAMILY SSF54427 168 287 3.93E-20 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 SUPERFAMILY SSF88659 100 157 9.53E-12 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 Pfam PF04542 Sigma-70 region 2 8 70 1.8E-13 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 SUPERFAMILY SSF88946 7 86 2.51E-13 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06505 2b494b156b48d1fbf788e4ba1b567b86 290 Pfam PF12680 SnoaL-like domain 173 269 5.1E-8 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS26410 10a6aa8b2ef05c95d3e752d7ae9e12f5 376 Pfam PF00756 Putative esterase 131 367 3.9E-14 T 17-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 SHXM_RS26410 10a6aa8b2ef05c95d3e752d7ae9e12f5 376 Gene3D G3DSA:3.40.50.1820 111 373 9.8E-42 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26410 10a6aa8b2ef05c95d3e752d7ae9e12f5 376 SUPERFAMILY SSF53474 109 373 5.45E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS18435 f5da2b5e5bbe51774bc5918d3d3b6361 165 SUPERFAMILY SSF55826 12 162 5.23E-43 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS18435 f5da2b5e5bbe51774bc5918d3d3b6361 165 Gene3D G3DSA:3.90.960.10 10 164 3.3E-58 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS18435 f5da2b5e5bbe51774bc5918d3d3b6361 165 Pfam PF04073 Aminoacyl-tRNA editing domain 37 153 3.6E-28 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS18435 f5da2b5e5bbe51774bc5918d3d3b6361 165 TIGRFAM TIGR00011 YbaK_EbsC: Cys-tRNA(Pro) deacylase 12 163 1.6E-55 T 17-03-2017 IPR004369 Prolyl-tRNA editing protein, YbaK/EbsC SHXM_RS18435 f5da2b5e5bbe51774bc5918d3d3b6361 165 PIRSF PIRSF006181 7 165 9.5E-53 T 17-03-2017 IPR004369 Prolyl-tRNA editing protein, YbaK/EbsC SHXM_RS46840 95e5d7cdb8df2ac29ba9fb7c6fc21e75 796 SUPERFAMILY SSF48208 274 727 1.05E-37 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS46840 95e5d7cdb8df2ac29ba9fb7c6fc21e75 796 Gene3D G3DSA:1.50.10.10 439 629 5.7E-9 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 Gene3D G3DSA:3.40.47.10 172 333 5.7E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 13 334 3.5E-110 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 SUPERFAMILY SSF53901 11 334 2.22E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 117 194 3.3E-26 T 17-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 Gene3D G3DSA:3.40.47.10 14 171 3.5E-54 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 245 334 3.1E-31 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS20310 b34b21a7ecb6a489e7922eee38407447 336 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 12 335 60.137 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 331 708 1.7E-56 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Pfam PF14310 Fibronectin type III-like domain 737 806 4.5E-20 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Gene3D G3DSA:3.40.50.1700 557 710 1.3E-66 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Gene3D G3DSA:3.40.50.1700 319 396 1.3E-66 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Pfam PF07691 PA14 domain 449 531 1.3E-5 T 17-03-2017 IPR011658 PA14 domain SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 SUPERFAMILY SSF51445 16 327 1.04E-85 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 SMART SM01217 737 807 1.6E-22 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 PRINTS PR00133 Glycosyl hydrolase family 3 signature 51 67 5.8E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 PRINTS PR00133 Glycosyl hydrolase family 3 signature 157 173 5.8E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 PRINTS PR00133 Glycosyl hydrolase family 3 signature 126 142 5.8E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 PRINTS PR00133 Glycosyl hydrolase family 3 signature 80 99 5.8E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 PRINTS PR00133 Glycosyl hydrolase family 3 signature 227 245 5.8E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 SUPERFAMILY SSF56988 449 602 2.48E-7 T 17-03-2017 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 SUPERFAMILY SSF52279 330 397 4.32E-48 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 SUPERFAMILY SSF52279 557 711 4.32E-48 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Gene3D G3DSA:3.20.20.300 17 305 1.6E-91 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS49540 317c130bce53856a8551a6e1f1c7ea77 818 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 68 295 6.2E-51 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 Gene3D G3DSA:2.160.20.10 61 453 6.6E-101 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 Pfam PF00295 Glycosyl hydrolases family 28 223 422 2.7E-18 T 17-03-2017 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 SUPERFAMILY SSF51126 59 447 2.26E-86 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 Pfam PF12708 Pectate lyase superfamily protein 69 111 3.1E-8 T 17-03-2017 IPR024535 Pectate lyase superfamily protein SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 SMART SM00710 280 301 5.2 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 SMART SM00710 314 335 62.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41380 ed8b2ef93fed2df706b1db01d6462905 484 SMART SM00710 255 279 2500.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 Pfam PF07690 Major Facilitator Superfamily 31 427 2.4E-56 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 SUPERFAMILY SSF103473 17 214 2.09E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 SUPERFAMILY SSF103473 492 517 2.09E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 SUPERFAMILY SSF103473 266 437 2.09E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 Gene3D G3DSA:1.20.1250.20 22 213 5.4E-33 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 Gene3D G3DSA:1.20.1250.20 281 438 4.6E-24 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 Gene3D G3DSA:1.20.1250.20 493 520 4.6E-24 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 320 344 5.8E-7 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 30 54 5.8E-7 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 125 145 5.8E-7 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 155 179 5.8E-7 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 418 437 5.8E-7 T 17-03-2017 SHXM_RS19385 43f93959bb740ebadbfde4109bfdf242 541 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 27 444 1.4E-77 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 160 172 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SUPERFAMILY SSF56112 38 356 6.61E-65 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 Gene3D G3DSA:3.30.200.20 37 110 2.5E-14 T 17-03-2017 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 Pfam PF00069 Protein kinase domain 42 288 1.8E-38 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00220 42 288 1.0E-41 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 Gene3D G3DSA:2.140.10.10 390 746 1.2E-63 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 Gene3D G3DSA:1.10.510.10 111 287 8.7E-39 T 17-03-2017 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 48 70 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 Pfam PF13360 PQQ-like domain 498 724 4.4E-35 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 Pfam PF13360 PQQ-like domain 432 497 1.3E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SUPERFAMILY SSF50998 432 558 4.32E-21 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 485 516 0.014 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 562 596 0.19 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 524 554 0.45 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 652 683 13.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 445 477 0.0033 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 691 726 6.4 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SMART SM00564 604 636 2.8E-8 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17745 8e4caeac34ee1052117ae94bb3573952 753 SUPERFAMILY SSF50998 563 740 7.2E-33 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 Gene3D G3DSA:1.10.540.10 20 110 1.4E-15 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 PIRSF PIRSF016578 1 402 6.1E-34 T 17-03-2017 SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 Gene3D G3DSA:2.40.110.10 142 227 3.4E-25 T 17-03-2017 SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 SUPERFAMILY SSF56645 27 235 9.56E-41 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 Gene3D G3DSA:1.20.140.10 228 395 6.4E-39 T 17-03-2017 SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 258 379 1.0E-17 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 SUPERFAMILY SSF47203 256 393 6.93E-23 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS46940 79501532778e77dedadb8b4861bbdfe7 411 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 133 226 1.3E-12 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 162 469 4.9E-83 T 17-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 Pfam PF05547 Immune inhibitor A peptidase M6 96 786 2.5E-222 T 17-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 Gene3D G3DSA:3.40.390.10 230 275 1.3E-25 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 Gene3D G3DSA:3.40.390.10 338 417 1.3E-25 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 SUPERFAMILY SSF55486 338 417 1.95E-16 T 17-03-2017 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 SUPERFAMILY SSF55486 225 284 1.95E-16 T 17-03-2017 SHXM_RS23450 65f6828b7a7e2dea3f4646509537f5a5 795 PIRSF PIRSF007519 3 794 1.9E-219 T 17-03-2017 IPR012300 Peptidase M6, InhA SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 SMART SM00100 26 144 1.8E-13 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 276 291 2.3E-32 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 383 407 2.3E-32 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 243 265 2.3E-32 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 345 353 2.3E-32 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 529 547 2.3E-32 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 Gene3D G3DSA:2.60.120.10 29 146 6.8E-18 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 Pfam PF00027 Cyclic nucleotide-binding domain 46 130 2.5E-15 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 244 263 1.3E-25 T 17-03-2017 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 474 490 1.3E-25 T 17-03-2017 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 519 541 1.3E-25 T 17-03-2017 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 344 362 1.3E-25 T 17-03-2017 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 387 405 1.3E-25 T 17-03-2017 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 243 555 2.3E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 Gene3D G3DSA:3.50.50.60 239 351 1.8E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 ProSitePatterns PS00888 Cyclic nucleotide-binding domain signature 1. 53 69 - T 17-03-2017 IPR018488 Cyclic nucleotide-binding, conserved site SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 SUPERFAMILY SSF51905 227 566 2.1E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 SUPERFAMILY SSF51206 29 149 5.63E-22 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS40045 dfc943822a3b20219a36e94b0e532cdc 600 Gene3D G3DSA:3.50.50.60 352 563 9.6E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 SUPERFAMILY SSF55785 176 302 7.15E-22 T 17-03-2017 IPR000014 PAS domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 SUPERFAMILY SSF55073 320 477 7.32E-41 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 Gene3D G3DSA:3.30.450.20 176 302 1.5E-23 T 17-03-2017 SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 Pfam PF00990 Diguanylate cyclase, GGDEF domain 315 472 1.5E-40 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 Gene3D G3DSA:3.30.70.270 316 482 2.3E-50 T 17-03-2017 SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 Gene3D G3DSA:3.20.20.450 490 742 5.9E-96 T 17-03-2017 IPR001633 EAL domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 186 311 1.6E-17 T 17-03-2017 IPR000014 PAS domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 Pfam PF08448 PAS fold 199 305 5.8E-11 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 SMART SM00052 486 738 1.1E-103 T 17-03-2017 IPR001633 EAL domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 313 476 1.3E-35 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 SMART SM00091 189 255 3.9E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 Pfam PF00563 EAL domain 494 733 3.5E-70 T 17-03-2017 IPR001633 EAL domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 SMART SM00267 304 476 1.5E-56 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS11835 32b2875967c8ca03129989049462ba31 748 SUPERFAMILY SSF141868 492 742 7.72E-83 T 17-03-2017 IPR001633 EAL domain SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 SUPERFAMILY SSF51395 393 739 3.14E-110 T 17-03-2017 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 SUPERFAMILY SSF51905 255 345 3.72E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 SUPERFAMILY SSF51905 2 150 3.72E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 Pfam PF01494 FAD binding domain 111 328 4.5E-16 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 396 732 5.5E-61 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 Gene3D G3DSA:3.50.50.60 2 42 1.6E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 Gene3D G3DSA:3.50.50.60 258 379 1.6E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 Gene3D G3DSA:3.50.50.60 96 166 1.6E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 129 144 1.6E-13 T 17-03-2017 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 2 24 1.6E-13 T 17-03-2017 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 316 332 1.6E-13 T 17-03-2017 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 268 283 1.6E-13 T 17-03-2017 SHXM_RS42030 66f18e82a22510346c4077d8de54dff0 793 Gene3D G3DSA:3.20.20.70 393 736 1.1E-117 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS46585 85f0195ca6bf364efd7e5971e58c3cee 306 SUPERFAMILY SSF51735 3 295 6.03E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46585 85f0195ca6bf364efd7e5971e58c3cee 306 Pfam PF01370 NAD dependent epimerase/dehydratase family 5 232 1.3E-19 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS46585 85f0195ca6bf364efd7e5971e58c3cee 306 Gene3D G3DSA:3.40.50.720 3 235 2.6E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17830 dee44ede919efcd3b5efd41af8d8a1b0 473 TIGRFAM TIGR01980 sufB: FeS assembly protein SufB 17 464 3.0E-221 T 17-03-2017 IPR010231 SUF system FeS cluster assembly, SufB GO:0016226 SHXM_RS17830 dee44ede919efcd3b5efd41af8d8a1b0 473 Pfam PF01458 Uncharacterized protein family (UPF0051) 219 444 3.4E-75 T 17-03-2017 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 SHXM_RS17830 dee44ede919efcd3b5efd41af8d8a1b0 473 SUPERFAMILY SSF101960 39 470 2.75E-139 T 17-03-2017 SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 SUPERFAMILY SSF52540 13 234 1.41E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 21 313 5.1E-97 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 Pfam PF00005 ABC transporter 29 172 2.2E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 Pfam PF13732 Domain of unknown function (DUF4162) 226 311 2.4E-6 T 17-03-2017 IPR025302 Domain of unknown function DUF4162 SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 ProSitePatterns PS00211 ABC transporters family signature. 145 159 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 SMART SM00382 38 221 6.6E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS21375 369ecc63ef10bfc1c6d6fbc0f8aad261 328 Gene3D G3DSA:3.40.50.300 9 234 1.3E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32100 0748e7dbbb81a3131135a0bbda3ef06e 216 TIGRFAM TIGR02428 pcaJ_scoB_fam: 3-oxoacid CoA-transferase, B subunit 3 208 2.6E-101 T 17-03-2017 IPR012791 3-oxoacid CoA-transferase, subunit B GO:0008410 SHXM_RS32100 0748e7dbbb81a3131135a0bbda3ef06e 216 SMART SM00882 6 202 1.3E-81 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS32100 0748e7dbbb81a3131135a0bbda3ef06e 216 SUPERFAMILY SSF100950 3 211 9.57E-74 T 17-03-2017 SHXM_RS32100 0748e7dbbb81a3131135a0bbda3ef06e 216 Pfam PF01144 Coenzyme A transferase 7 201 1.1E-46 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS32100 0748e7dbbb81a3131135a0bbda3ef06e 216 Gene3D G3DSA:3.40.810.20 3 210 9.2E-95 T 17-03-2017 SHXM_RS32100 0748e7dbbb81a3131135a0bbda3ef06e 216 ProSitePatterns PS01274 Coenzyme A transferases signature 2. 44 52 - T 17-03-2017 IPR004164 Coenzyme A transferase active site GO:0008152|GO:0008410 SHXM_RS14260 6621d7ba9b86afab1ea877dbdafa1dba 469 Gene3D G3DSA:1.20.1250.20 273 448 1.3E-14 T 17-03-2017 SHXM_RS14260 6621d7ba9b86afab1ea877dbdafa1dba 469 SUPERFAMILY SSF103473 13 209 1.03E-49 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14260 6621d7ba9b86afab1ea877dbdafa1dba 469 SUPERFAMILY SSF103473 257 450 1.03E-49 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14260 6621d7ba9b86afab1ea877dbdafa1dba 469 Gene3D G3DSA:1.20.1250.20 22 206 3.4E-28 T 17-03-2017 SHXM_RS14260 6621d7ba9b86afab1ea877dbdafa1dba 469 Pfam PF07690 Major Facilitator Superfamily 26 420 5.2E-44 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 SUPERFAMILY SSF100950 74 234 5.23E-25 T 17-03-2017 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 3.5E-9 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 3.5E-9 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 2.1E-15 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 Pfam PF00455 DeoR C terminal sensor domain 75 232 9.4E-45 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 SMART SM01134 73 234 1.7E-55 T 17-03-2017 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 SUPERFAMILY SSF46785 3 68 6.76E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 Gene3D G3DSA:3.40.50.1360 78 205 7.3E-8 T 17-03-2017 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 SMART SM00420 6 58 6.9E-13 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07760 7579f5199515f070a02698da9bb08e7f 253 Gene3D G3DSA:1.10.10.10 5 66 4.2E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 SUPERFAMILY SSF48008 83 215 7.32E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 SUPERFAMILY SSF46785 10 102 4.97E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 SMART SM00895 87 210 2.8E-10 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 77 1.4E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 Pfam PF07729 FCD domain 87 207 2.0E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 Gene3D G3DSA:1.10.10.10 6 78 1.2E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 SMART SM00345 19 77 1.3E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS15265 fb2af749d00847722eb3a5d9d29d95bb 222 Gene3D G3DSA:1.20.120.530 80 217 7.7E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 Pfam PF00106 short chain dehydrogenase 10 199 3.4E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 2.7E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 2.7E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 2.7E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 2.7E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 2.7E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 SUPERFAMILY SSF51735 9 241 3.36E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25145 8825511564ceac6d8fb6d0551050d63c 252 Gene3D G3DSA:3.40.50.720 10 229 1.5E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33285 af20dc6dbf6db2bc64eefb801cce0a8a 542 Gene3D G3DSA:3.90.76.10 81 233 1.0E-34 T 17-03-2017 SHXM_RS33285 af20dc6dbf6db2bc64eefb801cce0a8a 542 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 111 454 3.0E-63 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS33285 af20dc6dbf6db2bc64eefb801cce0a8a 542 SUPERFAMILY SSF53850 65 532 1.36E-103 T 17-03-2017 SHXM_RS33285 af20dc6dbf6db2bc64eefb801cce0a8a 542 Gene3D G3DSA:3.10.105.10 309 507 2.9E-37 T 17-03-2017 SHXM_RS33285 af20dc6dbf6db2bc64eefb801cce0a8a 542 PIRSF PIRSF002741 27 536 1.3E-66 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS06955 bfa36a6783928b51ea33792c7f8d3860 279 Pfam PF01116 Fructose-bisphosphate aldolase class-II 6 276 2.0E-78 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS06955 bfa36a6783928b51ea33792c7f8d3860 279 Gene3D G3DSA:3.20.20.70 1 275 2.1E-85 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS06955 bfa36a6783928b51ea33792c7f8d3860 279 TIGRFAM TIGR00167 cbbA: ketose-bisphosphate aldolase 2 274 3.1E-67 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS06955 bfa36a6783928b51ea33792c7f8d3860 279 PIRSF PIRSF001359 1 279 4.7E-71 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS06955 bfa36a6783928b51ea33792c7f8d3860 279 SUPERFAMILY SSF51569 3 276 6.15E-79 T 17-03-2017 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 SUPERFAMILY SSF53850 89 299 2.9E-27 T 17-03-2017 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 SUPERFAMILY SSF46785 5 114 6.9E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 Gene3D G3DSA:1.10.10.10 5 88 4.6E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 Gene3D G3DSA:3.40.190.10 188 266 4.1E-16 T 17-03-2017 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 8 64 3.4E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 Pfam PF03466 LysR substrate binding domain 91 295 1.7E-29 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 32 42 1.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 21 32 1.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 53 1.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS20065 77cdb968ad25f02375e3b73fc4e93bde 302 Gene3D G3DSA:3.40.190.10 91 187 1.3E-22 T 17-03-2017 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 Gene3D G3DSA:2.40.30.10 4 90 1.9E-27 T 17-03-2017 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 Gene3D G3DSA:3.40.50.80 91 229 7.7E-38 T 17-03-2017 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 SUPERFAMILY SSF52343 105 236 6.81E-36 T 17-03-2017 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 Pfam PF00970 Oxidoreductase FAD-binding domain 9 100 3.5E-15 T 17-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 SUPERFAMILY SSF54292 227 335 5.64E-27 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 258 329 1.5E-11 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 Gene3D G3DSA:3.10.20.30 230 335 6.1E-30 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 Pfam PF00175 Oxidoreductase NAD-binding domain 112 218 3.5E-17 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 SUPERFAMILY SSF63380 4 100 6.64E-28 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 286 294 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 PRINTS PR00406 Cytochrome B5 reductase signature 111 130 1.5E-10 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 PRINTS PR00406 Cytochrome B5 reductase signature 51 58 1.5E-10 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 PRINTS PR00406 Cytochrome B5 reductase signature 204 212 1.5E-10 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 PRINTS PR00406 Cytochrome B5 reductase signature 148 159 1.5E-10 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS47850 521526f3cde3cd8611b16c6f1a188a2d 336 PRINTS PR00406 Cytochrome B5 reductase signature 88 102 1.5E-10 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 Gene3D G3DSA:3.30.300.30 460 561 5.0E-22 T 17-03-2017 SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 SUPERFAMILY SSF56801 14 562 5.23E-128 T 17-03-2017 SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 Pfam PF13193 AMP-binding enzyme C-terminal domain 474 551 4.5E-18 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 Gene3D G3DSA:3.40.50.980 41 222 1.7E-25 T 17-03-2017 SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 Gene3D G3DSA:2.30.38.10 381 459 9.4E-17 T 17-03-2017 SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 Pfam PF00501 AMP-binding enzyme 47 465 1.1E-72 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS38915 ca06b76384b082a76429f6b891f5a8bf 573 Gene3D G3DSA:3.40.50.980 223 380 2.6E-24 T 17-03-2017 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SUPERFAMILY SSF55785 10 106 2.65E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Pfam PF13581 Histidine kinase-like ATPase domain 679 775 1.2E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Gene3D G3DSA:3.30.450.40 244 426 6.0E-35 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 125 241 3.6E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 15 105 1.2E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SUPERFAMILY SSF81606 464 665 8.11E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Pfam PF00989 PAS fold 21 106 3.5E-6 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SUPERFAMILY SSF55785 133 241 2.27E-10 T 17-03-2017 IPR000014 PAS domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Pfam PF01590 GAF domain 262 418 9.4E-9 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SMART SM00331 449 666 1.5E-36 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 476 666 7.6E-50 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SUPERFAMILY SSF55781 308 422 2.18E-14 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Gene3D G3DSA:3.30.450.20 15 105 2.3E-10 T 17-03-2017 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SMART SM00091 119 185 3.2 T 17-03-2017 IPR000014 PAS domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SMART SM00091 3 69 5.4 T 17-03-2017 IPR000014 PAS domain SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Gene3D G3DSA:3.30.450.20 124 232 1.7E-13 T 17-03-2017 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 Pfam PF08448 PAS fold 125 235 9.5E-20 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS40000 443168afa1af73902824bf549ee671f7 795 SUPERFAMILY SSF55874 710 787 1.54E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20815 f3b236a7e40c4ecdbc8789e957a6f66c 268 Pfam PF05175 Methyltransferase small domain 76 197 5.4E-11 T 17-03-2017 IPR007848 Methyltransferase small domain GO:0008168 SHXM_RS20815 f3b236a7e40c4ecdbc8789e957a6f66c 268 TIGRFAM TIGR03704 PrmC_rel_meth: putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific 16 263 4.3E-125 T 17-03-2017 IPR022446 Conserved hypothetical protein CHP03704, protein-(glutamine-N5) methyltransferase SHXM_RS20815 f3b236a7e40c4ecdbc8789e957a6f66c 268 Gene3D G3DSA:1.10.8.10 43 74 5.4E-5 T 17-03-2017 SHXM_RS20815 f3b236a7e40c4ecdbc8789e957a6f66c 268 SUPERFAMILY SSF53335 52 229 3.52E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20815 f3b236a7e40c4ecdbc8789e957a6f66c 268 Gene3D G3DSA:3.40.50.150 76 246 5.5E-45 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20815 f3b236a7e40c4ecdbc8789e957a6f66c 268 TIGRFAM TIGR00536 hemK_fam: methyltransferase, HemK family 45 236 5.1E-38 T 17-03-2017 IPR004556 Modification methylase HemK GO:0006479|GO:0008276 SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 ProSitePatterns PS00801 Transketolase signature 1. 24 44 - T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 Gene3D G3DSA:3.40.50.970 350 561 2.8E-73 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 TIGRFAM TIGR00232 tktlase_bact: transketolase 18 685 3.4E-235 T 17-03-2017 IPR005478 Transketolase, bacterial-like GO:0004802 KEGG: 00030+2.2.1.1|KEGG: 00710+2.2.1.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723|MetaCyc: PWY-6901 SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 Gene3D G3DSA:3.40.50.920 562 688 2.3E-47 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 Pfam PF02780 Transketolase, C-terminal domain 573 679 4.6E-11 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 Gene3D G3DSA:3.40.50.970 13 341 9.4E-111 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 SUPERFAMILY SSF52518 5 341 4.82E-103 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 Pfam PF02779 Transketolase, pyrimidine binding domain 370 551 3.3E-45 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 SUPERFAMILY SSF52922 557 688 1.03E-39 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 ProSitePatterns PS00802 Transketolase signature 2. 491 507 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 SUPERFAMILY SSF52518 358 553 6.78E-64 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 SMART SM00861 371 552 1.9E-66 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS17870 e131c14ba8f3083d95bb9e17d3a853f3 692 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 16 355 1.9E-135 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 Gene3D G3DSA:3.40.50.261 126 290 4.4E-66 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 ProSitePatterns PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 158 185 - T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 SUPERFAMILY SSF51735 1 128 2.18E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 Pfam PF02629 CoA binding domain 6 103 6.4E-26 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 TIGRFAM TIGR01019 sucCoAalpha: succinate-CoA ligase, alpha subunit 3 290 5.9E-126 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 SMART SM00881 4 104 5.0E-31 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 PRINTS PR01798 Succinyl-CoA synthase signature 86 103 4.2E-34 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 PRINTS PR01798 Succinyl-CoA synthase signature 212 225 4.2E-34 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 PRINTS PR01798 Succinyl-CoA synthase signature 181 199 4.2E-34 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 PRINTS PR01798 Succinyl-CoA synthase signature 244 261 4.2E-34 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 SUPERFAMILY SSF52210 129 290 2.88E-47 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 ProSitePatterns PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 240 253 - T 17-03-2017 IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 Pfam PF00549 CoA-ligase 158 275 1.4E-13 T 17-03-2017 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 Gene3D G3DSA:3.40.50.720 3 125 4.9E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25285 86df785cc371d7b88369c24890f3c68a 294 PIRSF PIRSF001553 1 293 3.8E-113 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 SUPERFAMILY SSF52794 19 115 9.24E-36 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 Pfam PF02302 PTS system, Lactose/Cellobiose specific IIB subunit 22 112 2.4E-17 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 ProSitePatterns PS00372 PTS EIIA domains phosphorylation site signature 2. 632 648 - T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 TIGRFAM TIGR01427 PTS_IIC_fructo: PTS system, Fru family, IIC component 140 474 2.6E-91 T 17-03-2017 IPR006327 Phosphotransferase system, fructose IIC component GO:0005351|GO:0008982|GO:0009401|GO:0016021 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 TIGRFAM TIGR00848 fruA: PTS system, fructose subfamily, IIA component 593 714 1.4E-33 T 17-03-2017 IPR004715 Phosphotransferase system, IIA component fructose subfamily GO:0008982|GO:0009401|GO:0016021 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 Gene3D G3DSA:3.40.50.2300 19 115 6.1E-40 T 17-03-2017 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 TIGRFAM TIGR00829 FRU: PTS system, Fru family, IIB component 22 103 2.2E-31 T 17-03-2017 IPR003353 Phosphotransferase system, fructose-specific IIB subunit GO:0009401|GO:0022877 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 Gene3D G3DSA:3.40.930.10 583 730 1.5E-41 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 SUPERFAMILY SSF55804 583 729 1.1E-34 T 17-03-2017 IPR016152 Phosphotransferase/anion transporter GO:0005215|GO:0006810 Reactome: R-HSA-425381 SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 588 727 8.2E-33 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS24160 04f51c0d8cf318b756ba28e9b66c1a73 731 Pfam PF02378 Phosphotransferase system, EIIC 149 423 1.1E-19 T 17-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 SMART SM00829 10 362 3.5E-4 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 Gene3D G3DSA:3.90.180.10 1 186 4.1E-59 T 17-03-2017 IPR011032 GroES-like SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 SUPERFAMILY SSF51735 156 328 1.64E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 58 72 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 Pfam PF00107 Zinc-binding dehydrogenase 194 319 7.6E-22 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 SUPERFAMILY SSF50129 1 190 9.13E-62 T 17-03-2017 IPR011032 GroES-like SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 Gene3D G3DSA:3.40.50.720 187 307 2.2E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41915 e104cb887d4347af4718eddf4d1a3869 369 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 150 2.5E-26 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 281 462 1.5E-24 T 17-03-2017 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 Gene3D G3DSA:3.40.50.300 5 209 9.0E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 TIGRFAM TIGR00379 cobB: cobyrinic acid a,c-diamide synthase 6 471 3.8E-115 T 17-03-2017 IPR004484 Cobyrinic acid a,c-diamide synthase CbiA GO:0009236|GO:0042242 SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 Hamap MF_00027 Cobyrinate a,c-diamide synthase [cbiA]. 4 464 40.592 T 17-03-2017 IPR004484 Cobyrinic acid a,c-diamide synthase CbiA GO:0009236|GO:0042242 SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 SUPERFAMILY SSF52540 6 212 4.82E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 SUPERFAMILY SSF52317 280 474 1.32E-31 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 7 189 2.9E-26 T 17-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SHXM_RS17535 4d18352e428dfdd0b8dbf4720d40054f 479 Gene3D G3DSA:3.40.50.880 280 474 1.6E-29 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS22535 a0ba9f0a9c054e3206be62b674e5bd07 457 Gene3D G3DSA:3.30.565.10 400 446 2.9E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22535 a0ba9f0a9c054e3206be62b674e5bd07 457 Pfam PF07730 Histidine kinase 238 303 4.9E-20 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS22535 a0ba9f0a9c054e3206be62b674e5bd07 457 SUPERFAMILY SSF55874 323 439 1.77E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 Gene3D G3DSA:1.10.287.130 203 257 4.2E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 Gene3D G3DSA:3.30.565.10 258 398 2.0E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 SMART SM00388 213 271 4.4E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 SUPERFAMILY SSF158472 158 210 7.45E-5 T 17-03-2017 SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 SMART SM00304 156 212 6.8E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 SUPERFAMILY SSF55874 261 398 2.88E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 Pfam PF00512 His Kinase A (phospho-acceptor) domain 214 270 1.6E-10 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 SUPERFAMILY SSF47384 196 269 1.16E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 SMART SM00387 309 437 9.5E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 309 398 6.5E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30265 3080bc6f13e2a236ae3cfb5a4e2135f2 451 Pfam PF00672 HAMP domain 137 209 1.3E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS49530 8615e992894c52914eeec53e868cc19e 309 SUPERFAMILY SSF53850 34 292 2.34E-43 T 17-03-2017 SHXM_RS49530 8615e992894c52914eeec53e868cc19e 309 Gene3D G3DSA:3.40.190.10 136 226 9.1E-8 T 17-03-2017 SHXM_RS49530 8615e992894c52914eeec53e868cc19e 309 TIGRFAM TIGR01098 3A0109s03R: phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein 9 256 4.7E-60 T 17-03-2017 IPR005770 Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein GO:0043190|GO:0055085 SHXM_RS49530 8615e992894c52914eeec53e868cc19e 309 Pfam PF12974 ABC transporter, phosphonate, periplasmic substrate-binding protein 39 290 1.1E-57 T 17-03-2017 SHXM_RS21250 3092ffc2a086c4b0ed746869fd19f4ca 165 Pfam PF02130 Uncharacterized protein family UPF0054 16 147 2.8E-36 T 17-03-2017 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 SHXM_RS21250 3092ffc2a086c4b0ed746869fd19f4ca 165 ProSitePatterns PS01306 Uncharacterized protein family UPF0054 signature. 119 129 - T 17-03-2017 IPR020549 Endoribonuclease YbeY, conserved site SHXM_RS21250 3092ffc2a086c4b0ed746869fd19f4ca 165 TIGRFAM TIGR00043 TIGR00043: rRNA maturation RNase YbeY 36 148 4.7E-31 T 17-03-2017 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 SHXM_RS21250 3092ffc2a086c4b0ed746869fd19f4ca 165 SUPERFAMILY SSF55486 3 149 8.79E-37 T 17-03-2017 SHXM_RS21250 3092ffc2a086c4b0ed746869fd19f4ca 165 Gene3D G3DSA:3.40.390.30 5 155 2.5E-42 T 17-03-2017 IPR023091 Metalloprotease catalytic domain, predicted GO:0004222 SHXM_RS21250 3092ffc2a086c4b0ed746869fd19f4ca 165 Hamap MF_00009 Endoribonuclease YbeY [ybeY]. 2 157 21.596 T 17-03-2017 IPR002036 Endoribonuclease YbeY GO:0004222|GO:0006364 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 SMART SM00387 336 446 6.8E-33 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 SMART SM00304 169 228 5.7E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 Pfam PF00672 HAMP domain 150 224 7.9E-14 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 Gene3D G3DSA:1.10.287.130 219 292 4.0E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 406 424 2.5E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 391 401 2.5E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 430 443 2.5E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 PRINTS PR00344 Bacterial sensor protein C-terminal signature 373 387 2.5E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 Pfam PF00512 His Kinase A (phospho-acceptor) domain 229 295 3.4E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 SUPERFAMILY SSF47384 212 294 5.69E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 SUPERFAMILY SSF158472 169 226 2.48E-5 T 17-03-2017 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 SMART SM00388 229 296 1.6E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 337 444 5.3E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 SUPERFAMILY SSF55874 285 445 6.55E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42300 3fae8d6872a5e2849bdc2e94974f1afc 454 Gene3D G3DSA:3.30.565.10 301 446 1.1E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 Hamap MF_00285 Potassium-transporting ATPase ATP-binding subunit [kdpB]. 12 686 40.355 T 17-03-2017 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF56784 293 317 1.26E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF56784 441 565 1.26E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF56784 373 405 1.26E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF81665 34 100 3.66E-13 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF81665 208 299 3.66E-13 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF81653 118 207 1.44E-20 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 Pfam PF00122 E1-E2 ATPase 69 296 3.3E-40 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 69 343 1.3E-29 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 374 608 2.0E-42 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 TIGRFAM TIGR01497 kdpB: K+-transporting ATPase, B subunit 15 682 0.0 T 17-03-2017 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 Pfam PF00702 haloacid dehalogenase-like hydrolase 301 536 2.5E-30 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 Gene3D G3DSA:2.70.150.10 37 208 7.0E-23 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 Gene3D G3DSA:3.40.50.1000 451 569 2.7E-36 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 Gene3D G3DSA:3.40.1110.10 316 450 5.3E-48 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 307 313 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 SUPERFAMILY SSF81660 316 456 4.58E-30 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 545 557 6.8E-25 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 154 168 6.8E-25 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 305 319 6.8E-25 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 469 479 6.8E-25 T 17-03-2017 SHXM_RS13760 b12877f2d19e32455cc8f27cb6864a5a 689 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 522 541 6.8E-25 T 17-03-2017 SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 Gene3D G3DSA:1.10.357.10 31 218 7.5E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 Pfam PF00440 Bacterial regulatory proteins, tetR family 41 86 9.8E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 SUPERFAMILY SSF46689 28 108 2.64E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 62 85 4.3E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 54 4.3E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 SUPERFAMILY SSF48498 108 216 5.29E-14 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS33310 52ae0bf16b867ba34254daf80c7de807 222 Pfam PF13977 Bacterial transcriptional repressor 111 220 2.6E-22 T 17-03-2017 SHXM_RS03340 07d3f3eb140e8dead3eddc02891116c7 125 SUPERFAMILY SSF54427 9 115 1.69E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS03340 07d3f3eb140e8dead3eddc02891116c7 125 Pfam PF12680 SnoaL-like domain 16 100 3.2E-9 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS03340 07d3f3eb140e8dead3eddc02891116c7 125 Gene3D G3DSA:3.10.450.50 9 112 2.6E-15 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF50129 4064 4201 8.81E-26 T 17-03-2017 IPR011032 GroES-like SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 1693 1818 7.06E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 1873 1969 7.06E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4746 4996 5.7E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1161 1411 2.8E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2715 2966 4.1E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF55048 5392 5444 6.8E-6 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.50.720 6099 6298 7.3E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.50.720 2337 2560 1.9E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.50.720 4374 4581 2.0E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.50.720 790 983 2.8E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF53901 4742 5119 1.11E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM01294 2621 2688 4.4E-6 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM01294 4654 4721 8.1E-4 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM01294 6379 6446 1.0E-6 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM01294 1070 1137 3.4E-6 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 180 275 1.28E-53 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 1 115 1.28E-53 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00829 4064 4368 2.0E-164 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 5903 6090 2.48E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF47336 1066 1176 4.97E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2647 2662 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00550 Phosphopantetheine attachment site 6381 6446 4.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00550 Phosphopantetheine attachment site 1071 1137 1.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00550 Phosphopantetheine attachment site 2622 2688 6.4E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00550 Phosphopantetheine attachment site 4656 4721 8.3E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00826 353 510 1.9E-74 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00826 5624 5783 3.8E-78 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00826 3598 3758 4.8E-79 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.30.70.250 1828 1866 6.3E-4 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00823 Phosphopantetheine attachment site 6378 6450 5.6E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00823 Phosphopantetheine attachment site 1069 1141 4.2E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00823 Phosphopantetheine attachment site 4653 4725 6.5E-35 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00823 Phosphopantetheine attachment site 2620 2692 4.3E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 4372 4602 1.1E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 5449 5548 2.46E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 5269 5394 2.46E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF47336 2617 2729 1.16E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.47.10 2979 3144 5.9E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.47.10 5009 5174 4.3E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.47.10 1424 1588 1.1E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF53901 2712 3088 1.03E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1419 1536 4.6E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2974 3091 5.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 5004 5121 2.7E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF53901 1159 1533 4.23E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF55048 1816 1868 1.06E-6 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.47.10 1163 1423 1.0E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.47.10 2717 2978 8.8E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1324 1340 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 6097 6331 9.45E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 791 968 7.5E-39 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4377 4554 2.8E-58 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2337 2513 2.5E-55 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6100 6277 3.5E-55 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 5124 5243 1.1E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1539 1656 2.5E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3094 3213 2.8E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 2335 2568 1.75E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.90.180.10 4079 4142 2.3E-7 T 17-03-2017 IPR011032 GroES-like SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 2250 2325 5.12E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF14765 Polyketide synthase dehydratase 353 623 1.7E-53 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF14765 Polyketide synthase dehydratase 3598 3869 2.7E-54 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF14765 Polyketide synthase dehydratase 5624 5894 1.6E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00012 Phosphopantetheine attachment site. 6405 6420 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 3423 3524 1.2E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF52151 3244 3368 1.2E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF13602 Zinc-binding dehydrogenase 4243 4368 8.4E-14 T 17-03-2017 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF47336 4648 4761 9.95E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 3874 4043 4.86E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 790 1029 7.06E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00698 Acyl transferase domain 5270 5576 3.1E-79 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00698 Acyl transferase domain 1694 1999 3.5E-83 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00698 Acyl transferase domain 1 307 6.8E-73 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF00698 Acyl transferase domain 3244 3549 4.0E-80 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF08659 KR domain 791 967 3.8E-48 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF08659 KR domain 2337 2511 1.3E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF08659 KR domain 4377 4552 8.0E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF08659 KR domain 6100 6275 7.9E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF47336 6371 6460 7.07E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:1.10.1200.10 1067 1141 1.5E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:1.10.1200.10 4651 4725 1.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:1.10.1200.10 6375 6451 5.4E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:1.10.1200.10 2618 2692 5.1E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4680 4695 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF55048 3366 3418 1.28E-6 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 4084 4140 5.1E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 630 774 1.06E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 179 301 2.5E-59 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 1 110 2.5E-59 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 1687 1813 1.2E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 5448 5570 7.3E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 3422 3544 3.6E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 3236 3363 3.6E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 5262 5389 7.3E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.366.10 1872 1995 1.2E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5272 5557 1.3E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3246 3531 7.6E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1 288 5.5E-91 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1696 1982 8.9E-113 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF55048 114 177 2.09E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.50.720 4155 4343 2.8E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 4909 4925 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 4163 4300 1.14E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00825 Beta-ketoacyl synthase 4748 5174 9.6E-224 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00825 Beta-ketoacyl synthase 1163 1589 2.8E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SMART SM00825 Beta-ketoacyl synthase 2717 3144 1.6E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 Gene3D G3DSA:3.40.47.10 4743 5008 3.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 SUPERFAMILY SSF51735 2086 2228 5.9E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1096 1111 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05380 a67996d9b0f067acdc76b0e7296f67fd 6531 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2879 2895 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46710 d7a6c001b7cfbe43f7b40ddd3a4cb77c 315 SUPERFAMILY SSF53328 1 204 3.53E-57 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS46710 d7a6c001b7cfbe43f7b40ddd3a4cb77c 315 Gene3D G3DSA:3.40.50.170 1 203 3.3E-53 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS46710 d7a6c001b7cfbe43f7b40ddd3a4cb77c 315 Pfam PF02911 Formyl transferase, C-terminal domain 204 306 5.2E-18 T 17-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS46710 d7a6c001b7cfbe43f7b40ddd3a4cb77c 315 Pfam PF00551 Formyl transferase 1 169 6.1E-32 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS46710 d7a6c001b7cfbe43f7b40ddd3a4cb77c 315 SUPERFAMILY SSF50486 204 308 1.57E-19 T 17-03-2017 IPR011034 Formyl transferase, C-terminal-like GO:0003824 SHXM_RS46710 d7a6c001b7cfbe43f7b40ddd3a4cb77c 315 Gene3D G3DSA:3.10.25.10 206 307 5.5E-20 T 17-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS09930 94aff4cea8d44f2ed6540a2c045d703d 370 Pfam PF03747 ADP-ribosylglycohydrolase 33 298 6.3E-25 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS09930 94aff4cea8d44f2ed6540a2c045d703d 370 SUPERFAMILY SSF101478 27 318 6.28E-36 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS39675 7be06170ac1cf61f47a7e5b2ce4982a1 254 SUPERFAMILY SSF53474 5 248 1.88E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39675 7be06170ac1cf61f47a7e5b2ce4982a1 254 Pfam PF00975 Thioesterase domain 24 244 5.3E-53 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS39675 7be06170ac1cf61f47a7e5b2ce4982a1 254 Gene3D G3DSA:3.40.50.1820 13 249 5.5E-34 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01320 1f30a92b45ea3334a6bcd7d59123f55e 257 Gene3D G3DSA:3.40.50.1820 22 254 1.3E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01320 1f30a92b45ea3334a6bcd7d59123f55e 257 PRINTS PR00111 Alpha/beta hydrolase fold signature 89 102 1.6E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01320 1f30a92b45ea3334a6bcd7d59123f55e 257 PRINTS PR00111 Alpha/beta hydrolase fold signature 199 213 1.6E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01320 1f30a92b45ea3334a6bcd7d59123f55e 257 PRINTS PR00111 Alpha/beta hydrolase fold signature 103 116 1.6E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01320 1f30a92b45ea3334a6bcd7d59123f55e 257 SUPERFAMILY SSF53474 18 253 3.89E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01320 1f30a92b45ea3334a6bcd7d59123f55e 257 Pfam PF12697 Alpha/beta hydrolase family 25 246 2.6E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS39775 393e94269f10af8a9991ebb22bd5a81a 203 Gene3D G3DSA:1.10.357.10 18 174 2.1E-23 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS39775 393e94269f10af8a9991ebb22bd5a81a 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 4.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39775 393e94269f10af8a9991ebb22bd5a81a 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 21 34 4.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39775 393e94269f10af8a9991ebb22bd5a81a 203 SUPERFAMILY SSF46689 10 76 1.05E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39775 393e94269f10af8a9991ebb22bd5a81a 203 SUPERFAMILY SSF48498 87 173 2.49E-8 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS39775 393e94269f10af8a9991ebb22bd5a81a 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 66 1.0E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 Gene3D G3DSA:3.30.390.10 20 154 3.9E-42 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 ProSitePatterns PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 218 249 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 Gene3D G3DSA:3.20.20.120 155 375 4.9E-77 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 52 151 2.3E-14 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 SMART SM00922 171 268 5.9E-27 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 SUPERFAMILY SSF51604 139 381 2.75E-73 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 SUPERFAMILY SSF54826 23 152 5.23E-29 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS03955 d25c23ca776690b49b945f1c43ca4dd2 392 Pfam PF13378 Enolase C-terminal domain-like 175 378 9.6E-64 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 Pfam PF01926 50S ribosome-binding GTPase 161 283 1.5E-22 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 TIGRFAM TIGR03595 Obg_CgtA_exten: Obg family GTPase CgtA, C-terminal extension 360 428 6.6E-25 T 17-03-2017 IPR015349 GTP-binding protein OBG, C-terminal GO:0000166 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 162 182 3.9E-35 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 227 245 3.9E-35 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 183 201 3.9E-35 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 210 225 3.9E-35 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 SUPERFAMILY SSF102741 357 429 5.75E-18 T 17-03-2017 IPR015349 GTP-binding protein OBG, C-terminal GO:0000166 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 Pfam PF09269 Domain of unknown function (DUF1967) 358 427 7.5E-23 T 17-03-2017 IPR015349 GTP-binding protein OBG, C-terminal GO:0000166 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 Gene3D G3DSA:3.40.50.300 160 344 1.4E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 SUPERFAMILY SSF82051 4 157 5.1E-46 T 17-03-2017 IPR006169 GTP1/OBG domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 Hamap MF_01454 GTPase Obg [obg]. 3 330 43.441 T 17-03-2017 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 SUPERFAMILY SSF52540 161 335 1.62E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 Gene3D G3DSA:2.70.210.12 3 156 2.7E-48 T 17-03-2017 IPR006169 GTP1/OBG domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 Pfam PF01018 GTP1/OBG 4 157 4.8E-52 T 17-03-2017 IPR006169 GTP1/OBG domain GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 TIGRFAM TIGR02729 Obg_CgtA: Obg family GTPase CgtA 4 328 7.1E-123 T 17-03-2017 IPR014100 GTP-binding protein Obg/CgtA GO:0000287|GO:0003924|GO:0005525 SHXM_RS21595 d03cd2f6f1bff0b4f64c9c4cfcc0480f 477 ProSitePatterns PS00905 GTP1/OBG family signature. 212 225 - T 17-03-2017 IPR006074 GTP1/OBG, conserved site GO:0005525 SHXM_RS48880 b11359dc0aab2f23c0124b1521cca03a 166 Pfam PF01613 Flavin reductase like domain 18 160 1.2E-33 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS48880 b11359dc0aab2f23c0124b1521cca03a 166 Gene3D G3DSA:2.30.110.10 9 164 2.3E-51 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS48880 b11359dc0aab2f23c0124b1521cca03a 166 SUPERFAMILY SSF50475 4 163 3.29E-47 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS48880 b11359dc0aab2f23c0124b1521cca03a 166 SMART SM00903 17 160 1.1E-51 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 Gene3D G3DSA:3.40.50.300 6 236 2.7E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 SMART SM00382 30 213 5.6E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 Gene3D G3DSA:2.40.50.140 285 359 2.7E-9 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 Pfam PF03459 TOBE domain 307 367 6.6E-8 T 17-03-2017 IPR005116 Transport-associated OB, type 1 SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 SUPERFAMILY SSF52540 7 245 6.84E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 Pfam PF00005 ABC transporter 22 163 1.7E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 SUPERFAMILY SSF50331 238 376 2.78E-21 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 Gene3D G3DSA:2.40.50.100 241 284 7.3E-8 T 17-03-2017 SHXM_RS25985 b7d5a326c71413770c31433e525e857f 378 Gene3D G3DSA:2.40.50.100 362 376 7.3E-8 T 17-03-2017 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 Gene3D G3DSA:1.10.601.10 76 155 3.4E-27 T 17-03-2017 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 84 304 1.2E-37 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 Pfam PF04545 Sigma-70, region 4 253 302 2.2E-16 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 Pfam PF04542 Sigma-70 region 2 88 157 3.2E-21 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 Gene3D G3DSA:1.10.10.10 156 211 2.8E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 SUPERFAMILY SSF88946 49 157 3.27E-32 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 PRINTS PR00046 Major sigma-70 factor signature 136 144 6.9E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 PRINTS PR00046 Major sigma-70 factor signature 112 125 6.9E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 PRINTS PR00046 Major sigma-70 factor signature 257 269 6.9E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 PRINTS PR00046 Major sigma-70 factor signature 289 300 6.9E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 PRINTS PR00046 Major sigma-70 factor signature 274 289 6.9E-10 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 82 304 7.8E-96 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 SUPERFAMILY SSF88659 224 304 1.33E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 Gene3D G3DSA:1.10.10.10 245 304 8.5E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 Pfam PF04539 Sigma-70 region 3 171 227 7.8E-15 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34630 bacd0e57949646faf1d530a911fef67a 308 SUPERFAMILY SSF88659 161 235 1.13E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS17595 f8790622bd07f93ee227f7f26d98b8fe 348 Pfam PF00266 Aminotransferase class-V 15 342 2.9E-21 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS17595 f8790622bd07f93ee227f7f26d98b8fe 348 SUPERFAMILY SSF53383 11 346 1.49E-52 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS17595 f8790622bd07f93ee227f7f26d98b8fe 348 Gene3D G3DSA:3.40.640.10 31 256 8.1E-36 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS17595 f8790622bd07f93ee227f7f26d98b8fe 348 Gene3D G3DSA:3.90.1150.10 257 347 1.3E-7 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS46675 76cf5c15d663e6e48889a632495f7f60 115 Pfam PF12680 SnoaL-like domain 14 102 2.8E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS46675 76cf5c15d663e6e48889a632495f7f60 115 SUPERFAMILY SSF54427 1 108 5.38E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS46675 76cf5c15d663e6e48889a632495f7f60 115 Gene3D G3DSA:3.10.450.50 3 106 6.8E-13 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS24710 1b95348ad11b3e7fed8493c80418e977 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 1.4E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS24710 1b95348ad11b3e7fed8493c80418e977 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 1.4E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS24710 1b95348ad11b3e7fed8493c80418e977 197 SUPERFAMILY SSF46689 10 91 4.73E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS24710 1b95348ad11b3e7fed8493c80418e977 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 71 6.6E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS24710 1b95348ad11b3e7fed8493c80418e977 197 SUPERFAMILY SSF48498 91 196 9.93E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS24710 1b95348ad11b3e7fed8493c80418e977 197 Gene3D G3DSA:1.10.357.10 14 197 1.0E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF81660 300 497 3.11E-47 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 562 682 1.5E-30 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 60 314 1.0E-45 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Gene3D G3DSA:1.20.1110.10 33 86 3.9E-96 T 17-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Gene3D G3DSA:1.20.1110.10 560 827 3.9E-96 T 17-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 563 579 4.6E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 623 648 4.6E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 591 607 4.6E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 452 470 4.6E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Pfam PF00122 E1-E2 ATPase 59 284 8.9E-65 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 615 627 7.9E-37 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 493 504 7.9E-37 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 139 153 7.9E-37 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 293 307 7.9E-37 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 515 525 7.9E-37 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 591 610 7.9E-37 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF56784 449 694 3.1E-52 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF56784 291 311 3.1E-52 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Pfam PF00689 Cation transporting ATPase, C-terminus 675 827 6.3E-34 T 17-03-2017 IPR006068 Cation-transporting P-type ATPase, C-terminal Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Gene3D G3DSA:2.70.150.10 87 194 5.2E-37 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Gene3D G3DSA:2.70.150.10 1 32 5.2E-37 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Gene3D G3DSA:3.40.1110.10 283 500 3.1E-48 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Pfam PF13246 Cation transport ATPase (P-type) 353 437 1.9E-20 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SMART SM00831 1 54 4.5E-9 T 17-03-2017 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF81653 92 194 9.02E-27 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 Pfam PF00690 Cation transporter/ATPase, N-terminus 1 48 4.0E-13 T 17-03-2017 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 295 301 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF81665 194 287 9.42E-104 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF81665 1 92 9.42E-104 T 17-03-2017 SHXM_RS43530 60b52b68254822c6c9913ba0181ef927 855 SUPERFAMILY SSF81665 641 832 9.42E-104 T 17-03-2017 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 Gene3D G3DSA:3.40.140.20 377 519 4.4E-50 T 17-03-2017 IPR024051 AICAR transformylase domain KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 TIGRFAM TIGR00355 purH: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 11 529 3.5E-172 T 17-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 Pfam PF02142 MGS-like domain 22 135 8.5E-24 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 Gene3D G3DSA:3.40.140.20 255 370 4.8E-44 T 17-03-2017 IPR024051 AICAR transformylase domain KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 SUPERFAMILY SSF52335 10 198 7.88E-63 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 PIRSF PIRSF000414 4 529 5.5E-195 T 17-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 SMART SM00798 141 463 2.1E-178 T 17-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 Pfam PF01808 AICARFT/IMPCHase bienzyme 141 462 1.9E-111 T 17-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 Hamap MF_00139 Bifunctional purine biosynthesis protein PurH [purH]. 10 529 41.664 T 17-03-2017 IPR002695 AICARFT/IMPCHase bienzyme GO:0003937|GO:0004643|GO:0006164 KEGG: 00230+3.5.4.10+2.1.2.3|KEGG: 00670+2.1.2.3|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 SMART SM00851 22 136 2.9E-48 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 Gene3D G3DSA:3.40.50.1380 8 191 5.9E-76 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS25265 b58e4eca9a12f21c9ddc4f4f2832dad3 529 SUPERFAMILY SSF53927 226 529 9.93E-114 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 Gene3D G3DSA:2.40.370.10 254 379 3.0E-19 T 17-03-2017 IPR023374 AttH-like domain SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 491 505 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 SUPERFAMILY SSF159245 143 380 8.11E-35 T 17-03-2017 SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 SUPERFAMILY SSF159245 29 111 8.11E-35 T 17-03-2017 SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 Pfam PF00348 Polyprenyl synthetase 441 694 2.6E-40 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 Pfam PF17186 Lipocalin-like domain 253 379 5.6E-16 T 17-03-2017 IPR033451 AttH, lipocalin-like domain SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 Gene3D G3DSA:2.40.370.10 30 241 3.6E-27 T 17-03-2017 IPR023374 AttH-like domain SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 629 641 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 Pfam PF07143 CrtC N-terminal lipocalin domain 37 239 8.3E-19 T 17-03-2017 IPR010791 AttH domain SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 SUPERFAMILY SSF48576 439 754 5.6E-57 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS02350 973b5d379ff72d9f87a9dba4f8c59e44 766 Gene3D G3DSA:1.10.600.10 439 755 2.7E-62 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS30055 5a345bece86dec069ffa3e8c4e730cb2 141 TIGRFAM TIGR00256 TIGR00256: D-tyrosyl-tRNA(Tyr) deacylase 1 141 7.9E-41 T 17-03-2017 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SHXM_RS30055 5a345bece86dec069ffa3e8c4e730cb2 141 Hamap MF_00518 D-aminoacyl-tRNA deacylase [dtd]. 1 141 30.214 T 17-03-2017 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SHXM_RS30055 5a345bece86dec069ffa3e8c4e730cb2 141 Pfam PF02580 D-Tyr-tRNA(Tyr) deacylase 2 140 9.7E-50 T 17-03-2017 IPR003732 D-aminoacyl-tRNA deacylase DTD GO:0005737|GO:0016788|GO:0019478 SHXM_RS30055 5a345bece86dec069ffa3e8c4e730cb2 141 Gene3D G3DSA:3.50.80.10 1 140 3.4E-53 T 17-03-2017 IPR023509 D-Tyr tRNAtyr deacylase-like domain SHXM_RS30055 5a345bece86dec069ffa3e8c4e730cb2 141 SUPERFAMILY SSF69500 1 140 2.75E-46 T 17-03-2017 IPR023509 D-Tyr tRNAtyr deacylase-like domain SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 Pfam PF00571 CBS domain 6 59 1.2E-12 T 17-03-2017 IPR000644 CBS domain SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 Pfam PF00571 CBS domain 89 142 3.4E-15 T 17-03-2017 IPR000644 CBS domain SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 Pfam PF04972 BON domain 145 212 4.7E-11 T 17-03-2017 IPR007055 BON domain SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 SUPERFAMILY SSF54631 2 144 4.83E-33 T 17-03-2017 SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 PIRSF PIRSF036990 4 223 3.8E-60 T 17-03-2017 IPR017080 Uncharacterised conserved protein UCP036990, CBS, BON SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 SMART SM00116 13 61 3.7E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 SMART SM00116 95 143 2.7E-12 T 17-03-2017 IPR000644 CBS domain SHXM_RS43025 4a0940f88d47731a76b2be03615a263e 224 Gene3D G3DSA:3.20.20.70 3 145 1.1E-30 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS06220 23076449db6c8e26d1e5e4df6f123218 105 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 2 103 1.1E-13 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS06220 23076449db6c8e26d1e5e4df6f123218 105 Gene3D G3DSA:3.10.105.10 57 103 7.8E-10 T 17-03-2017 SHXM_RS06220 23076449db6c8e26d1e5e4df6f123218 105 SUPERFAMILY SSF53850 2 104 1.34E-15 T 17-03-2017 SHXM_RS06220 23076449db6c8e26d1e5e4df6f123218 105 Gene3D G3DSA:3.40.190.10 2 56 3.4E-7 T 17-03-2017 SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 Hamap MF_01288 L-rhamnonate dehydratase [rhmD]. 5 397 73.385 T 17-03-2017 IPR023444 L-rhamnonate dehydratase GO:0050032 KEGG: 00051+4.2.1.90|MetaCyc: PWY-6713|MetaCyc: PWY-6714 SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 65 154 3.4E-12 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 129 154 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 Pfam PF13378 Enolase C-terminal domain-like 188 388 1.3E-45 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 SMART SM00922 160 266 5.3E-13 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 Gene3D G3DSA:3.30.390.10 5 159 1.6E-41 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 SUPERFAMILY SSF51604 142 388 1.07E-61 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 SUPERFAMILY SSF54826 53 159 1.13E-28 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS50035 83caa3135d8390c286c297541ba8114a 397 Gene3D G3DSA:3.20.20.120 160 382 6.0E-59 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS22960 3533fe7c5273922ee519c25c66a9dc17 251 Pfam PF01177 Asp/Glu/Hydantoin racemase 64 228 1.1E-6 T 17-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Pfam PF00364 Biotin-requiring enzyme 1066 1124 4.3E-14 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Gene3D G3DSA:3.40.50.20 1 130 1.5E-45 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Pfam PF02785 Biotin carboxylase C-terminal domain 339 447 1.1E-34 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Gene3D G3DSA:2.40.50.100 1050 1124 1.4E-20 T 17-03-2017 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SUPERFAMILY SSF56059 84 357 2.12E-71 T 17-03-2017 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Gene3D G3DSA:3.20.20.70 502 811 8.0E-127 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Pfam PF02436 Conserved carboxylase domain 820 1008 2.1E-54 T 17-03-2017 IPR003379 Carboxylase, conserved domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599|Reactome: R-HSA-70263 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Gene3D G3DSA:3.30.1490.20 131 201 1.8E-25 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SUPERFAMILY SSF51246 334 451 1.57E-37 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 117 322 4.3E-72 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 TIGRFAM TIGR01235 pyruv_carbox: pyruvate carboxylase 4 1124 0.0 T 17-03-2017 IPR005930 Pyruvate carboxylase GO:0004736|GO:0005524|GO:0006090|GO:0006094|GO:0009374 KEGG: 00020+6.4.1.1|KEGG: 00620+6.4.1.1|KEGG: 00720+6.4.1.1|MetaCyc: PWY-5750|MetaCyc: PWY-6142|MetaCyc: PWY-6146|Reactome: R-HSA-196780|Reactome: R-HSA-3371599|Reactome: R-HSA-70263 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Pfam PF00289 Biotin carboxylase, N-terminal domain 1 110 1.8E-40 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Gene3D G3DSA:3.10.600.10 959 1046 1.7E-30 T 17-03-2017 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SMART SM00878 339 446 1.2E-55 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SUPERFAMILY SSF51569 517 828 3.11E-75 T 17-03-2017 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 PIRSF PIRSF001594 1 1125 0.0 T 17-03-2017 IPR005930 Pyruvate carboxylase GO:0004736|GO:0005524|GO:0006090|GO:0006094|GO:0009374 KEGG: 00020+6.4.1.1|KEGG: 00620+6.4.1.1|KEGG: 00720+6.4.1.1|MetaCyc: PWY-5750|MetaCyc: PWY-6142|MetaCyc: PWY-6146|Reactome: R-HSA-196780|Reactome: R-HSA-3371599|Reactome: R-HSA-70263 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 286 293 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SUPERFAMILY SSF89000 825 991 1.49E-41 T 17-03-2017 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SUPERFAMILY SSF51230 1048 1124 1.96E-16 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Pfam PF00682 HMGL-like 525 792 2.7E-28 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 Gene3D G3DSA:3.30.470.20 205 451 4.3E-101 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS03830 effd91031586e9e3acde04d1fce59ed1 1125 SUPERFAMILY SSF52440 1 112 4.1E-41 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS10775 fcafd3d13f2b27b03285ac4ba1755d03 158 Gene3D G3DSA:3.40.47.10 2 47 2.4E-13 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10775 fcafd3d13f2b27b03285ac4ba1755d03 158 SMART SM00825 Beta-ketoacyl synthase 1 158 3.3E-14 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS10775 fcafd3d13f2b27b03285ac4ba1755d03 158 SUPERFAMILY SSF53901 2 158 5.76E-53 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10775 fcafd3d13f2b27b03285ac4ba1755d03 158 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 43 158 1.6E-37 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS10775 fcafd3d13f2b27b03285ac4ba1755d03 158 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2 35 2.1E-9 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS10775 fcafd3d13f2b27b03285ac4ba1755d03 158 Gene3D G3DSA:3.40.47.10 48 158 3.8E-39 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06950 10a950bd4633b41d10da16e3ffda7ff4 297 Gene3D G3DSA:3.40.50.10490 174 241 4.4E-20 T 17-03-2017 SHXM_RS06950 10a950bd4633b41d10da16e3ffda7ff4 297 Gene3D G3DSA:3.40.50.10490 261 294 1.1E-6 T 17-03-2017 SHXM_RS06950 10a950bd4633b41d10da16e3ffda7ff4 297 Gene3D G3DSA:3.40.50.10490 3 151 3.0E-20 T 17-03-2017 SHXM_RS06950 10a950bd4633b41d10da16e3ffda7ff4 297 SUPERFAMILY SSF53697 7 294 6.44E-43 T 17-03-2017 SHXM_RS06950 10a950bd4633b41d10da16e3ffda7ff4 297 Pfam PF01380 SIS domain 178 233 1.0E-5 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS06950 10a950bd4633b41d10da16e3ffda7ff4 297 Pfam PF01380 SIS domain 38 136 1.9E-6 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS48775 ca119cfb4ef06f60cc708ccf06b2fd6d 313 Pfam PF00005 ABC transporter 21 164 3.9E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS48775 ca119cfb4ef06f60cc708ccf06b2fd6d 313 SUPERFAMILY SSF52540 4 226 1.17E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48775 ca119cfb4ef06f60cc708ccf06b2fd6d 313 Gene3D G3DSA:3.40.50.300 3 228 1.5E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48775 ca119cfb4ef06f60cc708ccf06b2fd6d 313 SMART SM00382 30 241 2.7E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS48775 ca119cfb4ef06f60cc708ccf06b2fd6d 313 ProSitePatterns PS00211 ABC transporters family signature. 137 151 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48775 ca119cfb4ef06f60cc708ccf06b2fd6d 313 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 13 307 1.5E-105 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PIRSF PIRSF000350 1 462 6.9E-98 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 Gene3D G3DSA:3.50.50.60 141 335 4.4E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 176 194 2.2E-28 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 264 280 2.2E-28 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 293 315 2.2E-28 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 2.2E-28 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 137 155 2.2E-28 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 409 424 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 308 315 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 39 54 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 344 365 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 7 29 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 431 451 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 265 279 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 176 201 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 140 149 6.5E-49 T 17-03-2017 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 Gene3D G3DSA:3.50.50.60 5 140 1.4E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 SUPERFAMILY SSF51905 4 322 3.69E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 321 1.8E-55 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 Gene3D G3DSA:3.30.390.30 336 461 1.6E-33 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 SUPERFAMILY SSF55424 346 459 6.01E-31 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS33245 82103634c65c8d50c7cd651a5f12dc41 463 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 348 453 2.9E-25 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS14775 d01a3f5351f52ce8eeb12470f7f2d73d 376 Gene3D G3DSA:3.90.1510.10 43 276 5.2E-86 T 17-03-2017 IPR018193 Glycerate kinase, flavodoxin-like domain GO:0008887|GO:0031388 SHXM_RS14775 d01a3f5351f52ce8eeb12470f7f2d73d 376 SUPERFAMILY SSF110738 1 372 3.66E-109 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS14775 d01a3f5351f52ce8eeb12470f7f2d73d 376 Pfam PF02595 Glycerate kinase family 1 372 2.3E-127 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS14775 d01a3f5351f52ce8eeb12470f7f2d73d 376 PIRSF PIRSF006078 1 376 1.1E-113 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS14775 d01a3f5351f52ce8eeb12470f7f2d73d 376 TIGRFAM TIGR00045 TIGR00045: glycerate kinase 1 371 1.7E-113 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 TIGRFAM TIGR02891 CtaD_CoxA: cytochrome c oxidase, subunit I 28 524 1.4E-204 T 17-03-2017 IPR014241 Cytochrome c oxidase, subunit I bacterial type GO:0004129|GO:0005507|GO:0005886|GO:0006810|GO:0022900|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 36 480 1.1E-144 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 257 311 - T 17-03-2017 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 74 97 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 323 344 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 144 156 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 234 255 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 205 224 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 386 405 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 301 316 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 176 194 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 27 52 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 436 457 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 255 276 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 358 376 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 101 125 1.4E-104 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 SUPERFAMILY SSF81442 25 502 2.09E-168 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS49895 35221c02d349c8884fa2743e74a58a3a 554 Gene3D G3DSA:1.20.210.10 22 523 4.6E-184 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 SUPERFAMILY SSF49493 142 229 1.05E-15 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 Gene3D G3DSA:1.10.287.110 2 132 6.6E-33 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 SUPERFAMILY SSF46565 3 71 2.49E-28 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 Gene3D G3DSA:2.60.260.20 219 295 1.8E-19 T 17-03-2017 SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 Pfam PF01556 DnaJ C terminal domain 148 295 2.8E-34 T 17-03-2017 IPR002939 Chaperone DnaJ, C-terminal SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 SMART SM00271 3 60 2.7E-27 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 SUPERFAMILY SSF49493 221 306 1.44E-21 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 Gene3D G3DSA:2.60.260.20 136 216 1.7E-14 T 17-03-2017 SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 ProSitePatterns PS00636 Nt-dnaJ domain signature. 45 64 - T 17-03-2017 IPR018253 DnaJ domain, conserved site SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 Pfam PF00226 DnaJ domain 4 65 2.3E-24 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 PRINTS PR00625 DnaJ domain signature 40 60 2.0E-19 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 PRINTS PR00625 DnaJ domain signature 24 39 2.0E-19 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 PRINTS PR00625 DnaJ domain signature 6 24 2.0E-19 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS19610 f3232b6abc91cc73c2e7ec72cf408257 321 PRINTS PR00625 DnaJ domain signature 60 79 2.0E-19 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS04780 63ca5daec40be5e56579b7564119b7c1 417 Gene3D G3DSA:1.20.1250.20 235 406 1.1E-17 T 17-03-2017 SHXM_RS04780 63ca5daec40be5e56579b7564119b7c1 417 Gene3D G3DSA:1.20.1250.20 26 219 1.8E-8 T 17-03-2017 SHXM_RS04780 63ca5daec40be5e56579b7564119b7c1 417 SUPERFAMILY SSF103473 27 407 1.05E-30 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04780 63ca5daec40be5e56579b7564119b7c1 417 Pfam PF05977 Transmembrane secretion effector 175 401 6.9E-14 T 17-03-2017 IPR010290 Transmembrane secretion effector SHXM_RS48205 d4d88b4bb26ef7cb356ae63e8087adc7 80 SUPERFAMILY SSF48498 16 70 5.78E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19530 b3a7660d8a1e87734b6f5e77ecfc12f9 197 SUPERFAMILY SSF48498 82 187 5.26E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19530 b3a7660d8a1e87734b6f5e77ecfc12f9 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 7.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS19530 b3a7660d8a1e87734b6f5e77ecfc12f9 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 7.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS19530 b3a7660d8a1e87734b6f5e77ecfc12f9 197 SUPERFAMILY SSF46689 8 87 1.59E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19530 b3a7660d8a1e87734b6f5e77ecfc12f9 197 Gene3D G3DSA:1.10.357.10 13 189 1.3E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS19530 b3a7660d8a1e87734b6f5e77ecfc12f9 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 61 8.2E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30640 299f8c4a1d411d9718c95108c65ce687 307 Pfam PF01040 UbiA prenyltransferase family 43 283 2.1E-49 T 17-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SHXM_RS30640 299f8c4a1d411d9718c95108c65ce687 307 TIGRFAM TIGR01475 ubiA_other: putative 4-hydroxybenzoate polyprenyltransferase 20 301 6.1E-86 T 17-03-2017 IPR006371 4-hydroxybenzoate polyprenyltransferase-related SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 SUPERFAMILY SSF56003 62 663 1.05E-166 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.30.365.10 280 366 2.7E-54 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.30.365.10 521 663 2.7E-54 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.30.365.10 58 99 1.4E-11 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.30.365.10 207 247 1.4E-11 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 SMART SM01008 1 70 8.2E-4 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.90.1170.50 13 57 1.7E-13 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.30.365.10 367 508 1.5E-29 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 30 69 1.0E-9 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Gene3D G3DSA:3.30.365.10 100 200 7.0E-39 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 SUPERFAMILY SSF54665 2 84 5.63E-16 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47605 88afdf6add806f28e257c8798211edeb 664 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 86 607 6.2E-128 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 Pfam PF12852 Cupin 2 192 4.3E-48 T 17-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 SUPERFAMILY SSF46689 260 310 4.3E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 SUPERFAMILY SSF46689 207 258 6.45E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 261 304 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 Gene3D G3DSA:1.10.10.60 206 260 1.7E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 277 292 2.5E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 292 308 2.5E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 Gene3D G3DSA:1.10.10.60 261 310 1.3E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 Pfam PF12833 Helix-turn-helix domain 230 309 3.2E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS41350 eca65c238ada0e28a3584644a0864889 315 SMART SM00342 224 308 2.9E-30 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS07860 df57f89492eaeabf4d4cfa8ecc7b5b20 221 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 70 2.2E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS07860 df57f89492eaeabf4d4cfa8ecc7b5b20 221 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 84 168 1.1E-8 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS07860 df57f89492eaeabf4d4cfa8ecc7b5b20 221 SUPERFAMILY SSF46689 13 78 1.2E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07860 df57f89492eaeabf4d4cfa8ecc7b5b20 221 SUPERFAMILY SSF48498 83 195 2.0E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS07860 df57f89492eaeabf4d4cfa8ecc7b5b20 221 Gene3D G3DSA:1.10.357.10 10 219 1.6E-41 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 Pfam PF07859 alpha/beta hydrolase fold 50 250 5.5E-48 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 Gene3D G3DSA:2.120.10.30 281 327 4.4E-5 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 SUPERFAMILY SSF63829 261 530 5.56E-38 T 17-03-2017 SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 Gene3D G3DSA:2.120.10.30 328 517 1.0E-29 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 Hamap MF_01282 Virginiamycin B lyase [vgb]. 272 553 43.075 T 17-03-2017 IPR011217 Streptogramin lyase GO:0000287|GO:0016835|GO:0017001|GO:0046677 SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 Gene3D G3DSA:3.40.50.1820 25 266 8.6E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS15805 0105b19e630fa1325e08af31e7c384f9 555 SUPERFAMILY SSF53474 27 268 4.3E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS35135 a89949f0181c00fe47d2f0209a319a32 64 Pfam PF12728 Helix-turn-helix domain 10 60 7.8E-7 T 17-03-2017 SHXM_RS35135 a89949f0181c00fe47d2f0209a319a32 64 SUPERFAMILY SSF46955 9 60 1.65E-7 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS35135 a89949f0181c00fe47d2f0209a319a32 64 Gene3D G3DSA:1.10.10.10 19 61 9.2E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41085 81343b6669bf0bed3656dc69c0ae3346 483 ProSitePatterns PS00571 Amidases signature. 151 182 - T 17-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 SHXM_RS41085 81343b6669bf0bed3656dc69c0ae3346 483 SUPERFAMILY SSF75304 2 475 2.35E-119 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS41085 81343b6669bf0bed3656dc69c0ae3346 483 Pfam PF01425 Amidase 24 464 1.3E-99 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS41085 81343b6669bf0bed3656dc69c0ae3346 483 Gene3D G3DSA:3.90.1300.10 3 482 2.0E-122 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 TIGRFAM TIGR02483 PFK_mixed: phosphofructokinase 2 321 1.7E-147 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 Pfam PF00365 Phosphofructokinase 2 296 4.7E-102 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 ProSitePatterns PS00433 Phosphofructokinase signature. 265 283 - T 17-03-2017 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 Gene3D G3DSA:3.40.50.450 1 210 7.9E-74 T 17-03-2017 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 Hamap MF_01976 Pyrophosphate--fructose 6-phosphate 1-phosphotransferase [pfp]. 1 341 43.046 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PIRSF PIRSF000532 1 338 1.7E-121 T 17-03-2017 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 176 193 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 120 137 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 5 24 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 158 174 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 211 223 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 31 44 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 93 109 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 261 283 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 138 156 1.7E-73 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS27355 aa57d0b246955fdc48a9a84db4c86999 341 SUPERFAMILY SSF53784 1 331 1.31E-120 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 SUPERFAMILY SSF48498 68 151 8.75E-5 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 Gene3D G3DSA:1.10.357.10 48 176 2.6E-23 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 SUPERFAMILY SSF46689 1 72 6.98E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 Gene3D G3DSA:1.10.10.60 2 47 2.4E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 1 14 3.1E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 45 3.1E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48900 2cd327af0800ef80075cbf5ca2138bbe 181 Pfam PF00440 Bacterial regulatory proteins, tetR family 1 47 8.2E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20075 35f9499f61d99f42cef234e47f76f22a 242 Gene3D G3DSA:3.40.50.720 1 196 8.7E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20075 35f9499f61d99f42cef234e47f76f22a 242 Pfam PF13460 NAD(P)H-binding 7 172 8.7E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20075 35f9499f61d99f42cef234e47f76f22a 242 SUPERFAMILY SSF51735 1 214 1.71E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21995 b58b9cec9bbc34306777366604e186ce 174 Pfam PF13279 Thioesterase-like superfamily 11 124 6.3E-18 T 17-03-2017 SHXM_RS21995 b58b9cec9bbc34306777366604e186ce 174 SUPERFAMILY SSF54637 4 134 1.64E-32 T 17-03-2017 IPR029069 HotDog domain SHXM_RS21995 b58b9cec9bbc34306777366604e186ce 174 Gene3D G3DSA:3.10.129.10 3 134 2.6E-46 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 SMART SM00388 215 279 6.5E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 SUPERFAMILY SSF55874 325 425 1.84E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 Gene3D G3DSA:3.30.565.10 323 429 1.2E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 Pfam PF00672 HAMP domain 144 209 6.3E-11 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 Pfam PF00512 His Kinase A (phospho-acceptor) domain 216 276 1.4E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 329 422 4.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 SUPERFAMILY SSF47384 199 276 2.75E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 Gene3D G3DSA:1.10.287.130 205 275 1.1E-10 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 SUPERFAMILY SSF158472 162 209 2.75E-5 T 17-03-2017 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 SMART SM00304 162 214 2.4E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS45995 b9fa066cd70a79615bec90d6dfc5c55a 430 SMART SM00387 324 424 1.2E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11645 84b8762185776fc944c66596e034053e 255 Gene3D G3DSA:2.60.40.10 3 77 2.6E-14 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS11645 84b8762185776fc944c66596e034053e 255 SUPERFAMILY SSF81296 162 250 4.9E-14 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS11645 84b8762185776fc944c66596e034053e 255 SUPERFAMILY SSF81296 3 76 8.52E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS11645 84b8762185776fc944c66596e034053e 255 Gene3D G3DSA:2.60.40.10 153 250 1.6E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS11645 84b8762185776fc944c66596e034053e 255 Pfam PF01833 IPT/TIG domain 80 159 3.4E-12 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS11645 84b8762185776fc944c66596e034053e 255 Pfam PF01833 IPT/TIG domain 3 76 8.8E-11 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS11645 84b8762185776fc944c66596e034053e 255 Pfam PF01833 IPT/TIG domain 163 249 1.3E-10 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS11645 84b8762185776fc944c66596e034053e 255 Gene3D G3DSA:2.60.40.10 79 152 2.2E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS11645 84b8762185776fc944c66596e034053e 255 SMART SM00429 1 77 0.073 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS11645 84b8762185776fc944c66596e034053e 255 SMART SM00429 162 250 8.0E-4 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS11645 84b8762185776fc944c66596e034053e 255 SMART SM00429 79 160 0.0017 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS11645 84b8762185776fc944c66596e034053e 255 SUPERFAMILY SSF81296 79 152 1.4E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS04865 49bd7b7495c255e4985dccbc68f5fcb4 266 SMART SM00205 53 263 1.4E-8 T 17-03-2017 IPR001938 Thaumatin SHXM_RS04865 49bd7b7495c255e4985dccbc68f5fcb4 266 Pfam PF00314 Thaumatin family 57 215 7.7E-26 T 17-03-2017 IPR001938 Thaumatin SHXM_RS04865 49bd7b7495c255e4985dccbc68f5fcb4 266 PIRSF PIRSF002703 40 266 4.4E-23 T 17-03-2017 IPR001938 Thaumatin SHXM_RS04865 49bd7b7495c255e4985dccbc68f5fcb4 266 SUPERFAMILY SSF49870 52 262 4.19E-30 T 17-03-2017 IPR001938 Thaumatin SHXM_RS04865 49bd7b7495c255e4985dccbc68f5fcb4 266 Gene3D G3DSA:2.60.110.10 52 262 2.3E-33 T 17-03-2017 IPR001938 Thaumatin SHXM_RS19030 448de29ff384a69e07093caaf9e3e08e 321 Pfam PF08279 HTH domain 5 60 4.7E-16 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS19030 448de29ff384a69e07093caaf9e3e08e 321 SUPERFAMILY SSF46785 4 59 1.21E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19030 448de29ff384a69e07093caaf9e3e08e 321 Pfam PF13280 WYL domain 140 317 2.4E-41 T 17-03-2017 IPR026881 WYL domain SHXM_RS19030 448de29ff384a69e07093caaf9e3e08e 321 Gene3D G3DSA:1.10.10.10 2 63 1.1E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43610 ce6387844ef7579fbbaa12a2794ee8f7 388 SUPERFAMILY SSF53901 8 226 7.02E-22 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43610 ce6387844ef7579fbbaa12a2794ee8f7 388 PIRSF PIRSF000429 2 378 1.4E-16 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS43610 ce6387844ef7579fbbaa12a2794ee8f7 388 Gene3D G3DSA:3.40.47.10 196 220 3.8E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43610 ce6387844ef7579fbbaa12a2794ee8f7 388 Gene3D G3DSA:3.40.47.10 12 118 3.8E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43610 ce6387844ef7579fbbaa12a2794ee8f7 388 Gene3D G3DSA:3.40.47.10 263 368 6.1E-6 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43610 ce6387844ef7579fbbaa12a2794ee8f7 388 SUPERFAMILY SSF53901 231 371 5.76E-17 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 SUPERFAMILY SSF160240 296 375 4.71E-17 T 17-03-2017 SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 Pfam PF01545 Cation efflux family 101 294 5.2E-39 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 Gene3D G3DSA:3.30.70.1350 295 375 2.4E-19 T 17-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 Pfam PF16916 Dimerisation domain of Zinc Transporter 302 375 2.5E-16 T 17-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 Gene3D G3DSA:1.20.1510.10 99 294 3.4E-40 T 17-03-2017 IPR027469 Cation efflux protein transmembrane domain SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 98 374 7.2E-69 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS12055 c760368fbca7931b6469abada7651c83 392 SUPERFAMILY SSF161111 97 295 1.44E-47 T 17-03-2017 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 PRINTS PR00344 Bacterial sensor protein C-terminal signature 787 797 4.2E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 PRINTS PR00344 Bacterial sensor protein C-terminal signature 826 839 4.2E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 PRINTS PR00344 Bacterial sensor protein C-terminal signature 769 783 4.2E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 PRINTS PR00344 Bacterial sensor protein C-terminal signature 802 820 4.2E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Pfam PF13493 Domain of unknown function (DUF4118) 383 494 1.5E-25 T 17-03-2017 IPR025201 Sensor protein KdpD, transmembrane domain SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Gene3D G3DSA:3.40.50.300 2 210 3.6E-100 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 SUPERFAMILY SSF55874 682 839 2.75E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Pfam PF00582 Universal stress protein family 232 345 2.3E-5 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 SMART SM00387 732 842 1.9E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Gene3D G3DSA:1.20.120.620 392 486 1.2E-17 T 17-03-2017 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 SUPERFAMILY SSF52402 231 347 1.08E-8 T 17-03-2017 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 SMART SM00388 624 692 6.1E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Pfam PF00512 His Kinase A (phospho-acceptor) domain 625 692 3.5E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Gene3D G3DSA:3.30.565.10 678 841 6.6E-38 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 SUPERFAMILY SSF47384 615 692 5.3E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Gene3D G3DSA:3.40.50.620 226 346 1.9E-10 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Pfam PF02702 Osmosensitive K+ channel His kinase sensor domain 3 211 2.2E-100 T 17-03-2017 IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal GO:0000155|GO:0000160|GO:0004673|GO:0016020 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Gene3D G3DSA:1.10.287.130 615 677 2.6E-19 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37645 7992ba2a1f524890d4682a6d2d155d4e 870 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 734 840 1.9E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SMART SM00564 677 708 25.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SMART SM00564 408 441 49.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SMART SM00564 449 485 140.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SMART SM00564 635 666 0.41 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 Pfam PF13360 PQQ-like domain 425 621 7.0E-13 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 Gene3D G3DSA:3.30.200.20 7 89 2.8E-14 T 17-03-2017 SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 132 144 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SUPERFAMILY SSF56112 11 266 4.18E-60 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 Gene3D G3DSA:2.140.10.10 333 708 6.2E-28 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 20 42 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 Pfam PF01011 PQQ enzyme repeat 640 676 2.4E-4 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SUPERFAMILY SSF50998 390 563 5.89E-18 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SUPERFAMILY SSF50998 632 709 5.89E-18 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 Gene3D G3DSA:1.10.510.10 96 269 1.3E-38 T 17-03-2017 SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 SMART SM00220 14 267 4.5E-39 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28845 9ce947d687aba8c7482f6fca7131f4f4 753 Pfam PF00069 Protein kinase domain 15 262 2.9E-39 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 ProSitePatterns PS00798 Aldo/keto reductase family signature 1. 42 59 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 PIRSF PIRSF000097 1 285 8.8E-80 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 Gene3D G3DSA:3.20.20.100 8 285 5.0E-98 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 243 258 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 PRINTS PR00069 Aldo-keto reductase signature 94 112 7.5E-45 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 PRINTS PR00069 Aldo-keto reductase signature 161 190 7.5E-45 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 PRINTS PR00069 Aldo-keto reductase signature 127 144 7.5E-45 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 PRINTS PR00069 Aldo-keto reductase signature 38 62 7.5E-45 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 PRINTS PR00069 Aldo-keto reductase signature 210 234 7.5E-45 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 Pfam PF00248 Aldo/keto reductase family 25 274 2.0E-41 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS05605 913abfa9b272e25f7af383830bbac87d 293 SUPERFAMILY SSF51430 8 279 5.24E-86 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS09885 023430b992d537643268ad55aabb4000 289 Pfam PF01614 Bacterial transcriptional regulator 138 254 9.6E-24 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS09885 023430b992d537643268ad55aabb4000 289 SUPERFAMILY SSF55781 98 258 3.01E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09885 023430b992d537643268ad55aabb4000 289 Gene3D G3DSA:1.10.10.10 12 83 8.3E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09885 023430b992d537643268ad55aabb4000 289 Gene3D G3DSA:3.30.450.40 98 260 7.6E-37 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09885 023430b992d537643268ad55aabb4000 289 SUPERFAMILY SSF46785 13 83 9.25E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09885 023430b992d537643268ad55aabb4000 289 Pfam PF09339 IclR helix-turn-helix domain 14 63 2.0E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS09885 023430b992d537643268ad55aabb4000 289 SMART SM00346 12 101 2.3E-6 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 229 316 9.3E-24 T 17-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Gene3D G3DSA:3.40.120.10 44 221 1.8E-57 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 477 540 1.7E-7 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 SUPERFAMILY SSF53738 308 449 4.32E-25 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Gene3D G3DSA:3.40.120.10 313 451 4.8E-32 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 337 443 1.8E-15 T 17-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 ProSitePatterns PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 154 163 - T 17-03-2017 IPR016066 Alpha-D-phosphohexomutase, conserved site GO:0000287 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Gene3D G3DSA:3.40.120.10 235 312 5.8E-21 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Gene3D G3DSA:3.30.310.50 474 542 2.0E-18 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 SUPERFAMILY SSF53738 51 221 1.77E-41 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 SUPERFAMILY SSF53738 215 318 2.04E-21 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 SUPERFAMILY SSF55957 451 541 2.88E-14 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24735 2d0869570e8f41b9ce10730b49bcdfda 571 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 59 194 4.6E-41 T 17-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 SUPERFAMILY SSF52540 9 233 8.56E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 Pfam PF00005 ABC transporter 25 173 3.5E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 Pfam PF00005 ABC transporter 285 434 8.1E-14 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 ProSitePatterns PS00211 ABC transporters family signature. 411 425 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 Gene3D G3DSA:3.40.50.300 285 490 1.5E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 SMART SM00382 34 230 2.1E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 SUPERFAMILY SSF52540 284 491 1.41E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16030 979488f72827ecb1a1da7af234dbfdb8 528 Gene3D G3DSA:3.40.50.300 7 237 2.0E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 Gene3D G3DSA:1.10.10.10 39 118 7.6E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 SUPERFAMILY SSF53850 122 325 3.8E-39 T 17-03-2017 SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 51 62 5.2E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 72 83 5.2E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 62 72 5.2E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 Pfam PF03466 LysR substrate binding domain 121 321 3.0E-45 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 Gene3D G3DSA:3.40.190.10 123 208 2.1E-19 T 17-03-2017 SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 SUPERFAMILY SSF46785 38 117 2.1E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 Gene3D G3DSA:3.40.190.10 209 296 4.9E-30 T 17-03-2017 SHXM_RS24835 ad49068ae3c0e6e393df2bc07825b752 327 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 38 95 6.8E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS17530 b912dec362ff4f2c82d924de05cb1563 198 TIGRFAM TIGR00708 cobA: cob(I)yrinic acid a,c-diamide adenosyltransferase 19 198 2.0E-67 T 17-03-2017 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 SHXM_RS17530 b912dec362ff4f2c82d924de05cb1563 198 SUPERFAMILY SSF52540 12 198 3.44E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17530 b912dec362ff4f2c82d924de05cb1563 198 PIRSF PIRSF015617 1 198 9.2E-63 T 17-03-2017 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 SHXM_RS17530 b912dec362ff4f2c82d924de05cb1563 198 Pfam PF02572 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP 22 198 2.5E-58 T 17-03-2017 IPR003724 ATP:cob(I)alamin adenosyltransferase CobA/CobO/ButR GO:0005524|GO:0008817|GO:0009236 KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269 SHXM_RS17530 b912dec362ff4f2c82d924de05cb1563 198 Gene3D G3DSA:3.40.50.300 10 198 1.2E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26585 c5bbaa85971b216059d57c2e8032acdb 424 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 82 388 6.1E-64 T 17-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SHXM_RS26585 c5bbaa85971b216059d57c2e8032acdb 424 SUPERFAMILY SSF51445 71 415 3.64E-89 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS26585 c5bbaa85971b216059d57c2e8032acdb 424 Gene3D G3DSA:3.20.20.80 70 413 1.1E-114 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS26585 c5bbaa85971b216059d57c2e8032acdb 424 ProSitePatterns PS00659 Glycosyl hydrolases family 5 signature. 222 231 - T 17-03-2017 IPR018087 Glycoside hydrolase, family 5, conserved site GO:0004553|GO:0005975 SHXM_RS08640 82bcddb0dd93d959bb37bf57e6a818ac 172 SUPERFAMILY SSF53474 1 169 3.41E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08640 82bcddb0dd93d959bb37bf57e6a818ac 172 Pfam PF12697 Alpha/beta hydrolase family 1 165 2.2E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS08640 82bcddb0dd93d959bb37bf57e6a818ac 172 Gene3D G3DSA:3.40.50.1820 2 169 4.2E-19 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 Gene3D G3DSA:3.50.50.60 18 171 1.6E-7 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 Gene3D G3DSA:3.50.50.60 276 302 1.6E-7 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 SUPERFAMILY SSF51905 13 248 1.05E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 12 355 1.2E-107 T 17-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 208 233 3.7E-5 T 17-03-2017 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 168 177 3.7E-5 T 17-03-2017 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 14 36 3.7E-5 T 17-03-2017 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 Gene3D G3DSA:3.50.50.60 308 385 3.9E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 Gene3D G3DSA:3.50.50.60 274 275 3.9E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 Gene3D G3DSA:3.50.50.60 172 228 3.9E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 208 226 2.9E-6 T 17-03-2017 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 15 34 2.9E-6 T 17-03-2017 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 165 183 2.9E-6 T 17-03-2017 SHXM_RS46715 772f04888451aec9f9f8debc6d3c2c7e 451 SUPERFAMILY SSF51905 205 354 1.17E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18670 4d4c8192cefb31a0a62dec224e0350d4 305 Gene3D G3DSA:3.20.20.220 12 303 3.2E-106 T 17-03-2017 IPR029041 FAD-linked oxidoreductase-like SHXM_RS18670 4d4c8192cefb31a0a62dec224e0350d4 305 TIGRFAM TIGR00676 fadh2: methylenetetrahydrofolate reductase [NAD(P)H] 27 299 7.1E-100 T 17-03-2017 IPR004620 5,10-methylenetetrahydrofolate reductase GO:0004489|GO:0005829|GO:0009086|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841 SHXM_RS18670 4d4c8192cefb31a0a62dec224e0350d4 305 Pfam PF02219 Methylenetetrahydrofolate reductase 16 300 2.4E-109 T 17-03-2017 IPR003171 Methylenetetrahydrofolate reductase GO:0004489|GO:0006555|GO:0055114 KEGG: 00670+1.5.1.20|KEGG: 00720+1.5.1.20|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-196757 SHXM_RS18670 4d4c8192cefb31a0a62dec224e0350d4 305 SUPERFAMILY SSF51730 15 302 1.02E-95 T 17-03-2017 IPR029041 FAD-linked oxidoreductase-like SHXM_RS10800 33467fe4c0549b4e313a330f7e367790 329 Pfam PF03401 Tripartite tricarboxylate transporter family receptor 66 295 3.8E-25 T 17-03-2017 IPR005064 Bordetella uptake gene GO:0030288 SHXM_RS10800 33467fe4c0549b4e313a330f7e367790 329 Gene3D G3DSA:3.40.190.10 128 249 4.2E-9 T 17-03-2017 SHXM_RS10800 33467fe4c0549b4e313a330f7e367790 329 SUPERFAMILY SSF53850 124 300 1.17E-12 T 17-03-2017 SHXM_RS10800 33467fe4c0549b4e313a330f7e367790 329 PIRSF PIRSF017082 1 329 3.1E-83 T 17-03-2017 IPR005064 Bordetella uptake gene GO:0030288 SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 PIRSF PIRSF038800 3 402 3.8E-131 T 17-03-2017 IPR010111 Kynureninase GO:0005737|GO:0006569|GO:0009435|GO:0030170|GO:0030429 KEGG: 00380+3.7.1.3|MetaCyc: PWY-5651|MetaCyc: PWY-6309|Reactome: R-HSA-71240 SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 Gene3D G3DSA:3.40.640.10 81 258 3.1E-18 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 SUPERFAMILY SSF53383 12 398 2.01E-75 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 Hamap MF_01970 Kynureninase [kynU]. 5 398 34.106 T 17-03-2017 IPR010111 Kynureninase GO:0005737|GO:0006569|GO:0009435|GO:0030170|GO:0030429 KEGG: 00380+3.7.1.3|MetaCyc: PWY-5651|MetaCyc: PWY-6309|Reactome: R-HSA-71240 SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 TIGRFAM TIGR01814 kynureninase: kynureninase 11 398 2.3E-82 T 17-03-2017 IPR010111 Kynureninase GO:0005737|GO:0006569|GO:0009435|GO:0030170|GO:0030429 KEGG: 00380+3.7.1.3|MetaCyc: PWY-5651|MetaCyc: PWY-6309|Reactome: R-HSA-71240 SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 Pfam PF00266 Aminotransferase class-V 79 322 1.0E-12 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS29260 50f3d3587ac2f87a730a1f97e9193d16 402 Gene3D G3DSA:3.90.1150.10 259 400 5.4E-48 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 SUPERFAMILY SSF51445 278 558 1.66E-53 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 Gene3D G3DSA:3.20.20.80 280 559 5.0E-61 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 Pfam PF00704 Glycosyl hydrolases family 18 283 551 4.0E-30 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 SMART SM00636 281 551 2.5E-7 T 17-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 ProSitePatterns PS01095 Chitinases family 18 active site. 388 396 - T 17-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 SMART SM00060 187 257 1.7E-13 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 SUPERFAMILY SSF49785 46 178 1.62E-11 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 Pfam PF00041 Fibronectin type III domain 189 260 4.1E-8 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 Gene3D G3DSA:2.60.120.260 44 179 2.0E-11 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 Pfam PF02018 Carbohydrate binding domain 47 161 5.4E-14 T 17-03-2017 IPR003305 Carbohydrate-binding, CenC-like GO:0016798 SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 Gene3D G3DSA:2.60.40.10 186 264 5.4E-21 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS33435 66d5def117ab51b269af0c8ea1af0cc2 570 SUPERFAMILY SSF49265 186 267 1.57E-17 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SUPERFAMILY SSF53474 1083 1357 1.92E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SMART SM00824 Thioesterase 1103 1357 0.0026 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:1.10.1200.10 1012 1077 3.5E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SUPERFAMILY SSF47336 1001 1073 9.03E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Pfam PF00668 Condensation domain 32 328 2.0E-43 T 17-03-2017 IPR001242 Condensation domain SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Pfam PF00501 AMP-binding enzyme 494 900 4.2E-102 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 ProSitePatterns PS00455 Putative AMP-binding domain signature. 642 653 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Pfam PF00975 Thioesterase domain 1101 1347 8.3E-31 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SUPERFAMILY SSF52777 218 452 6.78E-38 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SUPERFAMILY SSF56801 455 1021 1.31E-166 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:3.30.300.30 896 1011 3.6E-36 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:2.30.38.10 812 890 1.8E-27 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 518 923 1.3E-138 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:3.40.50.980 488 650 3.7E-48 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Pfam PF00550 Phosphopantetheine attachment site 1010 1073 2.5E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SUPERFAMILY SSF52777 34 212 1.01E-25 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Pfam PF13193 AMP-binding enzyme C-terminal domain 908 983 2.1E-10 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:3.40.50.980 651 811 7.1E-47 T 17-03-2017 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 SMART SM00823 Phosphopantetheine attachment site 1008 1077 0.003 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:3.40.50.1820 1287 1359 1.9E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23625 69c7e35b144b7a65aad1122c289c7aa9 1383 Gene3D G3DSA:3.40.50.1820 1083 1204 1.9E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22055 d7727f70b2489823350b5fc118782c3b 156 SUPERFAMILY SSF116726 79 154 4.19E-16 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS22055 d7727f70b2489823350b5fc118782c3b 156 PIRSF PIRSF005028 1 156 9.2E-51 T 17-03-2017 IPR026278 Potassium/proton antiporter subunit KhtT SHXM_RS22055 d7727f70b2489823350b5fc118782c3b 156 Gene3D G3DSA:3.30.70.1450 81 154 5.0E-19 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS22055 d7727f70b2489823350b5fc118782c3b 156 Pfam PF02080 TrkA-C domain 85 154 3.3E-14 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Gene3D G3DSA:3.40.1440.10 18 95 4.3E-10 T 17-03-2017 IPR027299 GIY-YIG domain SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Pfam PF08459 UvrC Helix-hairpin-helix N-terminal 393 596 3.8E-53 T 17-03-2017 IPR001162 UvrC family homology region SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Pfam PF01541 GIY-YIG catalytic domain 19 92 1.2E-10 T 17-03-2017 IPR000305 GIY-YIG nuclease superfamily SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Hamap MF_00203 UvrABC system protein C [uvrC]. 4 661 30.538 T 17-03-2017 IPR004791 UvrABC system, subunit C GO:0005737|GO:0006281|GO:0009380|GO:0009381 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Gene3D G3DSA:1.10.150.20 612 662 3.0E-20 T 17-03-2017 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Gene3D G3DSA:4.10.860.10 187 246 6.2E-18 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 SMART SM00278 610 629 120.0 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 SMART SM00278 642 661 0.087 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 SUPERFAMILY SSF82771 17 101 7.19E-23 T 17-03-2017 IPR000305 GIY-YIG nuclease superfamily SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Pfam PF02151 UvrB/uvrC motif 210 242 4.0E-11 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 SUPERFAMILY SSF47781 571 663 1.3E-22 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 SUPERFAMILY SSF46600 194 246 7.06E-14 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 SMART SM00465 17 99 3.6E-19 T 17-03-2017 IPR000305 GIY-YIG nuclease superfamily SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 TIGRFAM TIGR00194 uvrC: excinuclease ABC subunit C 11 467 4.0E-130 T 17-03-2017 IPR004791 UvrABC system, subunit C GO:0005737|GO:0006281|GO:0009380|GO:0009381 SHXM_RS17950 0b095dd1cea77ef2fad23a1017bf287f 697 Pfam PF14520 Helix-hairpin-helix domain 612 662 8.8E-10 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF13193 AMP-binding enzyme C-terminal domain 936 1015 7.4E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SUPERFAMILY SSF52777 28 204 1.45E-52 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF00550 Phosphopantetheine attachment site 1044 1106 1.5E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Gene3D G3DSA:3.40.50.980 677 840 9.4E-34 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 ProSitePatterns PS00455 Putative AMP-binding domain signature. 667 678 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF00501 AMP-binding enzyme 488 928 6.7E-91 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SMART SM00823 Phosphopantetheine attachment site 1042 1111 3.1E-9 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Gene3D G3DSA:3.40.50.980 483 595 2.3E-49 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Gene3D G3DSA:3.40.50.980 652 676 2.3E-49 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Gene3D G3DSA:3.30.300.30 922 1026 2.9E-40 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SUPERFAMILY SSF47336 1034 1107 4.06E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SUPERFAMILY SSF56801 447 1054 5.36E-156 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SUPERFAMILY SSF52777 1133 1304 1.08E-46 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF00668 Condensation domain 1129 1422 5.8E-62 T 17-03-2017 IPR001242 Condensation domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF00668 Condensation domain 25 323 1.2E-72 T 17-03-2017 IPR001242 Condensation domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1066 1081 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 509 952 2.4E-130 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SUPERFAMILY SSF52777 211 452 1.11E-59 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Gene3D G3DSA:1.10.1200.10 1030 1110 5.6E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 SUPERFAMILY SSF52777 1312 1576 1.78E-41 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Gene3D G3DSA:2.30.38.10 841 918 1.4E-30 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF13745 HxxPF-repeated domain 345 435 1.9E-25 T 17-03-2017 SHXM_RS05395 afebe5170a071303d3b790c0860fa3f6 1584 Pfam PF13745 HxxPF-repeated domain 1445 1554 1.8E-10 T 17-03-2017 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 Gene3D G3DSA:1.20.1250.20 278 472 7.7E-19 T 17-03-2017 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 Gene3D G3DSA:1.20.1250.20 36 222 2.1E-29 T 17-03-2017 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 TIGRFAM TIGR00879 SP: MFS transporter, sugar porter (SP) family 17 468 7.9E-102 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 SUPERFAMILY SSF103473 17 472 1.44E-75 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 PRINTS PR00171 Sugar transporter signature 374 395 1.8E-26 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 PRINTS PR00171 Sugar transporter signature 125 144 1.8E-26 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 PRINTS PR00171 Sugar transporter signature 42 52 1.8E-26 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 PRINTS PR00171 Sugar transporter signature 397 409 1.8E-26 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 PRINTS PR00171 Sugar transporter signature 285 295 1.8E-26 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 Pfam PF00083 Sugar (and other) transporter 34 473 2.5E-102 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS11345 c644af65f567a0a6801d558e805fdd12 478 ProSitePatterns PS00217 Sugar transport proteins signature 2. 130 155 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS24635 4ba74a174fd1d601b58148a7050919eb 425 Gene3D G3DSA:2.40.440.10 260 393 6.9E-20 T 17-03-2017 SHXM_RS24635 4ba74a174fd1d601b58148a7050919eb 425 SUPERFAMILY SSF141523 260 392 1.19E-21 T 17-03-2017 SHXM_RS24635 4ba74a174fd1d601b58148a7050919eb 425 Pfam PF03734 L,D-transpeptidase catalytic domain 258 392 2.2E-13 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 373 393 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 14 257 1.2E-36 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 268 462 4.2E-33 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 SUPERFAMILY SSF53067 14 260 5.18E-57 T 17-03-2017 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 PIRSF PIRSF000538 11 507 4.6E-105 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 Gene3D G3DSA:3.30.420.40 264 501 3.7E-56 T 17-03-2017 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 Gene3D G3DSA:3.30.420.40 14 257 9.3E-59 T 17-03-2017 SHXM_RS40725 387553cc3132bcbb36efec23169f6343 525 SUPERFAMILY SSF53067 264 507 5.0E-50 T 17-03-2017 SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 Pfam PF01039 Carboxyl transferase domain 41 529 8.0E-194 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 Gene3D G3DSA:3.90.226.10 280 531 3.9E-100 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 SUPERFAMILY SSF52096 257 531 1.44E-88 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 142 160 4.6E-6 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 108 122 4.6E-6 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 Gene3D G3DSA:3.90.226.10 13 269 6.7E-81 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS15095 36093337be3ee13e8f168525541b16e7 531 SUPERFAMILY SSF52096 18 269 7.47E-81 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS36295 e7ee054e70d16722654535930b04a328 1298 SUPERFAMILY SSF55874 588 709 9.43E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36295 e7ee054e70d16722654535930b04a328 1298 Pfam PF00672 HAMP domain 401 485 1.0E-17 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS36295 e7ee054e70d16722654535930b04a328 1298 Pfam PF08376 Nitrate and nitrite sensing 137 381 5.9E-40 T 17-03-2017 IPR013587 Nitrate/nitrite sensing protein SHXM_RS36295 e7ee054e70d16722654535930b04a328 1298 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 604 710 2.3E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36295 e7ee054e70d16722654535930b04a328 1298 SMART SM00304 419 489 1.5E-5 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS36295 e7ee054e70d16722654535930b04a328 1298 Gene3D G3DSA:3.30.565.10 568 713 5.1E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01590 6a3b1a97ee8192208f68903be83af738 47 Gene3D G3DSA:1.10.10.60 2 45 2.2E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01590 6a3b1a97ee8192208f68903be83af738 47 SUPERFAMILY SSF46689 2 44 9.41E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01590 6a3b1a97ee8192208f68903be83af738 47 Pfam PF12833 Helix-turn-helix domain 2 42 6.3E-9 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS17750 6e0415d9f1b804f72f2684301330426e 191 SUPERFAMILY SSF46689 13 82 1.05E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS17750 6e0415d9f1b804f72f2684301330426e 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 60 2.2E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17750 6e0415d9f1b804f72f2684301330426e 191 SUPERFAMILY SSF48498 81 165 2.17E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS17750 6e0415d9f1b804f72f2684301330426e 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 59 1.5E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17750 6e0415d9f1b804f72f2684301330426e 191 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 15 28 1.5E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17750 6e0415d9f1b804f72f2684301330426e 191 Gene3D G3DSA:1.10.357.10 13 163 1.1E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Pfam PF02146 Sir2 family 39 240 7.0E-44 T 17-03-2017 IPR003000 Sirtuin family GO:0070403 SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Gene3D G3DSA:3.30.1600.10 137 210 3.4E-19 T 17-03-2017 IPR026591 Sirtuin family, catalytic core small domain SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Gene3D G3DSA:3.30.1600.10 50 84 3.4E-19 T 17-03-2017 IPR026591 Sirtuin family, catalytic core small domain SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Gene3D G3DSA:3.40.50.1220 33 49 2.2E-39 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Gene3D G3DSA:3.40.50.1220 217 291 2.2E-39 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Gene3D G3DSA:3.40.50.1220 99 136 2.2E-39 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 SUPERFAMILY SSF52467 23 289 3.69E-74 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS41015 5f33071e07cf221d6b443ee7f91f822b 297 Hamap MF_01967 NAD-dependent protein deacetylase [cobB]. 16 285 64.844 T 17-03-2017 IPR026587 Sirtuin, class II SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 Gene3D G3DSA:3.40.50.720 7 245 1.1E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 245 5.2E-52 T 17-03-2017 SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 SUPERFAMILY SSF51735 10 245 4.93E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 11 186 0.0013 T 17-03-2017 SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 1.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 1.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47145 5ee6d7e0519e006be5cc591ebcf9363e 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 1.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 SUPERFAMILY SSF51735 4 240 2.21E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 Gene3D G3DSA:3.40.50.720 4 240 7.3E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 Pfam PF00106 short chain dehydrogenase 10 198 2.9E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 206 226 7.2E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 7.2E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 138 154 7.2E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 183 7.2E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 86 97 7.2E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22885 3b9f505d27e741df859c8a77f91c7924 242 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 7.2E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 ProSitePatterns PS00114 Phosphoribosyl pyrophosphate synthase signature. 136 151 - T 17-03-2017 IPR000842 Phosphoribosyl pyrophosphate synthetase, conserved site GO:0000287|GO:0004749|GO:0009156|GO:0044249 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1|Reactome: R-HSA-73843 SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 Hamap MF_00583_B Ribose-phosphate pyrophosphokinase [prs]. 12 322 46.719 T 17-03-2017 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 Pfam PF14572 Phosphoribosyl synthetase-associated domain 215 321 1.7E-22 T 17-03-2017 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 TIGRFAM TIGR01251 ribP_PPkin: ribose-phosphate diphosphokinase 13 322 6.6E-114 T 17-03-2017 IPR005946 Ribose-phosphate diphosphokinase GO:0000287|GO:0004749|GO:0009165 KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 SMART SM01400 12 128 8.9E-71 T 17-03-2017 SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 SUPERFAMILY SSF53271 77 313 3.81E-61 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 Gene3D G3DSA:3.40.50.2020 9 167 2.8E-69 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 Gene3D G3DSA:3.40.50.2020 168 294 3.1E-46 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS32800 79d139dd652d6977d4ba4928d1fd722b 325 Pfam PF13793 N-terminal domain of ribose phosphate pyrophosphokinase 13 128 6.0E-45 T 17-03-2017 IPR029099 Ribose-phosphate pyrophosphokinase, N-terminal domain KEGG: 00030+2.7.6.1|KEGG: 00230+2.7.6.1 SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 27 42 1.1E-11 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 74 89 1.1E-11 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 59 74 1.1E-11 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 SMART SM00418 25 103 3.9E-29 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 SUPERFAMILY SSF46785 12 103 1.68E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 Pfam PF01022 Bacterial regulatory protein, arsR family 33 77 1.3E-14 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05930 7da2ab817500eee5ed96666738f6ffd9 131 Gene3D G3DSA:1.10.10.10 6 107 6.2E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34425 9812ec3f9d8df117cd036a643ad2acf0 186 Gene3D G3DSA:1.10.357.10 3 170 2.4E-26 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34425 9812ec3f9d8df117cd036a643ad2acf0 186 Pfam PF00440 Bacterial regulatory proteins, tetR family 8 54 6.5E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34425 9812ec3f9d8df117cd036a643ad2acf0 186 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 8 21 3.8E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34425 9812ec3f9d8df117cd036a643ad2acf0 186 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 52 3.8E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34425 9812ec3f9d8df117cd036a643ad2acf0 186 SUPERFAMILY SSF46689 4 73 1.89E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 PRINTS PR00046 Major sigma-70 factor signature 389 400 8.4E-30 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 PRINTS PR00046 Major sigma-70 factor signature 205 218 8.4E-30 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 PRINTS PR00046 Major sigma-70 factor signature 353 365 8.4E-30 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 PRINTS PR00046 Major sigma-70 factor signature 229 237 8.4E-30 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 PRINTS PR00046 Major sigma-70 factor signature 374 389 8.4E-30 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Pfam PF04539 Sigma-70 region 3 260 336 1.5E-26 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 SUPERFAMILY SSF88946 113 251 1.1E-50 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Gene3D G3DSA:1.10.10.10 254 305 1.7E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Pfam PF00140 Sigma-70 factor, region 1.2 116 149 8.1E-15 T 17-03-2017 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 205 218 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Gene3D G3DSA:1.10.601.10 106 250 2.7E-62 T 17-03-2017 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Pfam PF04545 Sigma-70, region 4 349 402 7.0E-20 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 177 402 5.2E-38 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Gene3D G3DSA:1.10.10.10 343 414 2.2E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 Pfam PF04542 Sigma-70 region 2 181 250 5.7E-23 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 SUPERFAMILY SSF88659 254 327 4.23E-18 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 SUPERFAMILY SSF88659 312 410 3.92E-28 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20600 305a6bb81b77e67e8a695e5d085cc3ca 414 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 374 400 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37040 6ce76e84b97d11aea8bf927a0ba72918 485 Pfam PF08817 WXG100 protein secretion system (Wss), protein YukD 9 83 2.5E-20 T 17-03-2017 IPR024962 YukD-like SHXM_RS37040 6ce76e84b97d11aea8bf927a0ba72918 485 TIGRFAM TIGR03920 T7SS_EccD: type VII secretion integral membrane protein EccD 12 480 3.5E-55 T 17-03-2017 IPR006707 Type VII secretion system membrane protein EccD SHXM_RS37040 6ce76e84b97d11aea8bf927a0ba72918 485 PIRSF PIRSF017804 1 484 6.3E-121 T 17-03-2017 IPR006707 Type VII secretion system membrane protein EccD SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 Gene3D G3DSA:2.30.40.10 4 74 3.0E-28 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 TIGRFAM TIGR02033 D-hydantoinase: dihydropyrimidinase 6 459 5.4E-167 T 17-03-2017 IPR011778 Hydantoinase/dihydropyrimidinase GO:0005737 Reactome: R-HSA-399956 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 SUPERFAMILY SSF51338 5 71 5.28E-8 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 Pfam PF01979 Amidohydrolase family 56 439 8.0E-26 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 Gene3D G3DSA:3.20.20.140 75 382 2.1E-113 T 17-03-2017 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 SUPERFAMILY SSF51338 362 462 4.32E-32 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 Gene3D G3DSA:2.30.40.10 383 460 1.5E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14860 2c5885f412050f90ae714f268eb3bf3e 467 SUPERFAMILY SSF51556 60 388 5.9E-103 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Gene3D G3DSA:1.10.1240.10 640 725 7.5E-32 T 17-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Pfam PF02310 B12 binding domain 734 850 4.2E-20 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Pfam PF02574 Homocysteine S-methyltransferase 26 316 1.2E-66 T 17-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Gene3D G3DSA:3.20.20.330 13 355 9.0E-105 T 17-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Gene3D G3DSA:3.10.196.10 947 1166 6.5E-72 T 17-03-2017 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 SMART SM01018 646 728 3.5E-42 T 17-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 PIRSF PIRSF000381 10 1168 0.0 T 17-03-2017 IPR011822 Cobalamin-dependent methionine synthase GO:0008270|GO:0008705|GO:0008898|GO:0009086|GO:0031419 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 SUPERFAMILY SSF47644 645 727 1.19E-24 T 17-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 SUPERFAMILY SSF52242 728 863 9.03E-38 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Gene3D G3DSA:3.40.50.280 731 861 3.0E-46 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 SUPERFAMILY SSF56507 892 1167 4.58E-94 T 17-03-2017 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 TIGRFAM TIGR02082 metH: methionine synthase 22 1166 0.0 T 17-03-2017 IPR011822 Cobalamin-dependent methionine synthase GO:0008270|GO:0008705|GO:0008898|GO:0009086|GO:0031419 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 SUPERFAMILY SSF51717 348 619 8.5E-74 T 17-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Pfam PF02965 Vitamin B12 dependent methionine synthase, activation domain 966 1166 1.9E-41 T 17-03-2017 IPR004223 Vitamin B12-dependent methionine synthase, activation domain GO:0005622|GO:0008705|GO:0009086 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|MetaCyc: PWY-2201|MetaCyc: PWY-3841|Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 SUPERFAMILY SSF82282 17 390 9.03E-104 T 17-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Gene3D G3DSA:3.20.20.20 356 618 1.6E-84 T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Pfam PF00809 Pterin binding enzyme 351 587 2.6E-45 T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS15980 8adafc1c05450282c5efb15100ca898b 1168 Pfam PF02607 B12 binding domain 649 721 1.3E-25 T 17-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 PIRSF PIRSF001112 1 369 1.3E-118 T 17-03-2017 IPR016292 Epoxide hydrolase GO:0033961 KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 PRINTS PR00412 Epoxide hydrolase signature 122 137 3.8E-16 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 PRINTS PR00412 Epoxide hydrolase signature 167 180 3.8E-16 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 PRINTS PR00412 Epoxide hydrolase signature 102 120 3.8E-16 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 PRINTS PR00412 Epoxide hydrolase signature 341 363 3.8E-16 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 Pfam PF06441 Epoxide hydrolase N terminus 6 111 2.0E-36 T 17-03-2017 IPR010497 Epoxide hydrolase, N-terminal KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 Gene3D G3DSA:3.40.50.1820 3 367 1.2E-136 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS44315 117d775e0c80703cbf8ba932c3c49f03 369 SUPERFAMILY SSF53474 4 365 2.51E-101 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09375 c41007df514c1fc8179d35a9be6013ac 455 Gene3D G3DSA:3.40.309.10 244 426 1.3E-56 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS09375 c41007df514c1fc8179d35a9be6013ac 455 SUPERFAMILY SSF53720 3 454 1.19E-130 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS09375 c41007df514c1fc8179d35a9be6013ac 455 Pfam PF00171 Aldehyde dehydrogenase family 3 451 2.9E-143 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS09375 c41007df514c1fc8179d35a9be6013ac 455 Gene3D G3DSA:3.40.605.10 3 243 5.3E-74 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 858 891 7.3E-8 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 774 809 8.0E-5 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 753 788 6.2E-8 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 899 934 1.3E-8 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 731 768 2.8E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 1173 1202 8.7E-7 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 795 831 6.1E-5 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 647 683 2.1E-8 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 980 1014 1.1E-7 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 690 723 1.6E-8 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF05593 RHS Repeat 1088 1115 8.7E-5 T 17-03-2017 IPR031325 RHS repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 647 683 6.4E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 899 933 1.4E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 980 1009 1.4E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 627 666 1.6E-9 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1173 1204 5.9E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 690 729 4.1E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 731 771 3.5E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 774 814 4.4E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 857 898 2.0E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 1300 1374 1.6E-23 T 17-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 SHXM_RS35915 721d53cea29aacea11ef4dcee460a6c0 1437 Pfam PF03527 RHS protein 1275 1305 4.2E-9 T 17-03-2017 IPR001826 RHS protein SHXM_RS02010 0f38fe4bb646e51b1891dc4ce8e05ab8 353 Pfam PF09084 NMT1/THI5 like 91 216 5.0E-10 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS02010 0f38fe4bb646e51b1891dc4ce8e05ab8 353 Gene3D G3DSA:3.40.190.10 138 216 6.0E-12 T 17-03-2017 SHXM_RS02010 0f38fe4bb646e51b1891dc4ce8e05ab8 353 SUPERFAMILY SSF53850 55 274 3.57E-25 T 17-03-2017 SHXM_RS23375 92b257eb52954b8b99fb04683106636d 211 SUPERFAMILY SSF52972 11 207 3.4E-65 T 17-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like SHXM_RS23375 92b257eb52954b8b99fb04683106636d 211 TIGRFAM TIGR00042 TIGR00042: non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family 15 202 2.4E-49 T 17-03-2017 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206|Reactome: R-HSA-15869 SHXM_RS23375 92b257eb52954b8b99fb04683106636d 211 Gene3D G3DSA:3.90.950.10 10 209 3.6E-78 T 17-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like SHXM_RS23375 92b257eb52954b8b99fb04683106636d 211 Hamap MF_01405 dITP/XTP pyrophosphatase [rdgB]. 13 208 46.075 T 17-03-2017 IPR020922 Non-canonical purine NTP pyrophosphatase GO:0009143|GO:0017111 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206 SHXM_RS23375 92b257eb52954b8b99fb04683106636d 211 Pfam PF01725 Ham1 family 15 203 9.6E-52 T 17-03-2017 IPR002637 Ham1-like protein GO:0016787 KEGG: 00230+3.6.1.19|KEGG: 00240+3.6.1.19|KEGG: 00983+3.6.1.19|MetaCyc: PWY-7206|Reactome: R-HSA-15869 SHXM_RS40475 c62401d5c7e19921d28115cc33937d42 67 Pfam PF06305 Protein of unknown function (DUF1049) 1 49 3.0E-7 T 17-03-2017 IPR010445 Lipopolysaccharide assembly protein A domain GO:0005887 SHXM_RS32555 4ac71a852ffd299402976853756b9065 748 Gene3D G3DSA:1.20.1640.10 138 340 1.3E-33 T 17-03-2017 SHXM_RS32555 4ac71a852ffd299402976853756b9065 748 Gene3D G3DSA:1.20.1640.10 487 711 1.5E-31 T 17-03-2017 SHXM_RS32555 4ac71a852ffd299402976853756b9065 748 Pfam PF03176 MMPL family 440 706 6.7E-35 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS32555 4ac71a852ffd299402976853756b9065 748 Pfam PF03176 MMPL family 45 376 3.0E-81 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS32555 4ac71a852ffd299402976853756b9065 748 SUPERFAMILY SSF82866 143 334 6.8E-31 T 17-03-2017 SHXM_RS32555 4ac71a852ffd299402976853756b9065 748 SUPERFAMILY SSF82866 464 705 1.96E-26 T 17-03-2017 SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 Pfam PF00005 ABC transporter 22 163 5.0E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 Gene3D G3DSA:2.40.50.140 253 318 9.5E-4 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 SMART SM00382 30 213 3.8E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 Gene3D G3DSA:3.40.50.300 2 236 7.8E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 SUPERFAMILY SSF52540 6 242 3.14E-87 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 SUPERFAMILY SSF50331 244 325 1.19E-8 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS12955 5f848935a925820702f79c3b665ce87c 344 Pfam PF08402 TOBE domain 250 322 2.8E-9 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 SUPERFAMILY SSF49303 228 317 1.78E-11 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 106 182 2.7E-15 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 359 472 1.0E-4 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Gene3D G3DSA:2.60.40.320 215 318 8.6E-17 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 SUPERFAMILY SSF49785 47 222 5.71E-44 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 SUPERFAMILY SSF51445 315 598 8.13E-59 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Pfam PF00703 Glycosyl hydrolases family 2 226 317 4.9E-8 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Gene3D G3DSA:2.60.120.260 47 214 2.7E-51 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Pfam PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain 623 761 7.8E-49 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 SUPERFAMILY SSF110221 611 766 1.57E-53 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Gene3D G3DSA:2.80.10.50 611 766 1.1E-40 T 17-03-2017 SHXM_RS10865 bb534f99a6e72d49babd79b8ef66d286 767 Gene3D G3DSA:3.20.20.80 331 590 1.0E-47 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 ProSitePatterns PS00551 Prokaryotic molybdopterin oxidoreductases signature 1. 235 253 - T 17-03-2017 IPR027467 Molybdopterin oxidoreductase, molybdopterin cofactor binding site GO:0051539 KEGG: 00910+1.7.99.4 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 152 163 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 SUPERFAMILY SSF53706 194 284 1.46E-18 T 17-03-2017 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Pfam PF00037 4Fe-4S binding domain 194 211 3.7E-7 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Gene3D G3DSA:3.10.20.30 14 71 2.2E-7 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 SUPERFAMILY SSF54292 13 127 1.03E-30 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 SMART SM00926 230 284 5.7E-19 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Gene3D G3DSA:2.20.25.90 240 283 3.0E-21 T 17-03-2017 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Pfam PF12837 4Fe-4S binding domain 147 165 1.8E-5 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 11 87 2.0E-21 T 17-03-2017 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 232 284 3.6E-20 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 196 207 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Gene3D G3DSA:3.30.70.20 204 239 4.7E-6 T 17-03-2017 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 Gene3D G3DSA:3.30.70.20 138 203 5.8E-14 T 17-03-2017 SHXM_RS14245 c837792f9c0f56a194afda015d7886cb 290 SUPERFAMILY SSF54862 86 218 1.53E-24 T 17-03-2017 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 TIGRFAM TIGR01009 rpsC_bact: ribosomal protein uS3 1 207 5.7E-93 T 17-03-2017 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 Gene3D G3DSA:3.30.1140.32 107 206 2.6E-42 T 17-03-2017 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 SUPERFAMILY SSF54814 2 105 1.15E-34 T 17-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 SMART SM00322 59 124 4.4E-7 T 17-03-2017 IPR004087 K Homology domain GO:0003676 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 ProSitePatterns PS00548 Ribosomal protein S3 signature. 162 196 - T 17-03-2017 IPR018280 Ribosomal protein S3, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 SUPERFAMILY SSF54821 106 205 1.07E-37 T 17-03-2017 IPR001351 Ribosomal protein S3, C-terminal GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 Pfam PF07650 KH domain 38 109 4.8E-19 T 17-03-2017 IPR004044 K Homology domain, type 2 GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 Hamap MF_01309_B 30S ribosomal protein S3 [rpsC]. 1 205 37.884 T 17-03-2017 IPR005704 Ribosomal protein S3, bacterial GO:0003735|GO:0006412|GO:0015935 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 Pfam PF00189 Ribosomal protein S3, C-terminal domain 119 201 1.0E-36 T 17-03-2017 SHXM_RS31195 9ad7621c527cab23253107b30b3101d4 277 Gene3D G3DSA:3.30.300.20 17 106 1.7E-31 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 Pfam PF01614 Bacterial transcriptional regulator 119 230 6.4E-14 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 Pfam PF09339 IclR helix-turn-helix domain 3 55 4.7E-5 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 SUPERFAMILY SSF55781 60 237 1.63E-36 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 SUPERFAMILY SSF46785 3 70 2.77E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 Gene3D G3DSA:3.30.450.40 76 238 4.5E-38 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 Gene3D G3DSA:1.10.10.10 2 75 8.2E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46340 0620c4328dc63f7dfeae7eb75714dabe 250 SMART SM00346 1 91 0.0023 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS50265 0e984a9afd8097eb492c0aa31caa723a 521 Pfam PF00474 Sodium:solute symporter family 33 435 1.8E-29 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 Pfam PF01022 Bacterial regulatory protein, arsR family 35 80 1.7E-11 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 30 45 4.7E-13 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 62 77 4.7E-13 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 77 92 4.7E-13 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 SMART SM00418 28 106 5.0E-23 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 SUPERFAMILY SSF46785 17 108 2.52E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12105 d23ab37bd3070c90fae520195ebb41f8 119 Gene3D G3DSA:1.10.10.10 15 110 3.8E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08170 091da85e587a12932ddfe03771905149 504 Gene3D G3DSA:3.30.70.20 442 504 3.2E-8 T 17-03-2017 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 SMART SM00928 312 356 1.4E-4 T 17-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 Pfam PF13459 4Fe-4S single cluster domain 445 502 9.3E-9 T 17-03-2017 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 Pfam PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 316 396 1.1E-17 T 17-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 53 209 7.8E-28 T 17-03-2017 IPR011538 NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 SUPERFAMILY SSF54862 443 502 7.95E-7 T 17-03-2017 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 SUPERFAMILY SSF142019 29 231 1.57E-36 T 17-03-2017 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 SUPERFAMILY SSF142984 238 303 4.45E-6 T 17-03-2017 SHXM_RS08170 091da85e587a12932ddfe03771905149 504 SUPERFAMILY SSF140490 308 405 6.02E-18 T 17-03-2017 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 SUPERFAMILY SSF52507 2 176 1.31E-57 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 Pfam PF04127 DNA / pantothenate metabolism flavoprotein 187 371 2.5E-69 T 17-03-2017 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 Pfam PF02441 Flavoprotein 5 130 3.4E-31 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 Gene3D G3DSA:3.40.50.1950 2 177 4.6E-60 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 TIGRFAM TIGR00521 coaBC_dfp: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase 4 397 2.2E-117 T 17-03-2017 IPR005252 Coenzyme A biosynthesis bifunctional protein CoaBC GO:0004632|GO:0004633|GO:0010181|GO:0015937|GO:0015941 KEGG: 00770+4.1.1.36+6.3.2.5 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 Gene3D G3DSA:3.40.50.10300 185 400 2.9E-79 T 17-03-2017 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 SHXM_RS12325 f45b2d9c08c26493034018484e8f1c43 402 SUPERFAMILY SSF102645 186 400 3.92E-66 T 17-03-2017 IPR007085 DNA/pantothenate metabolism flavoprotein, C-terminal KEGG: 00770+6.3.2.5|Reactome: R-HSA-196783 SHXM_RS15700 77c12641a3fc7bb4c92a45e383486aa2 355 Pfam PF13683 Integrase core domain 259 324 9.4E-13 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15700 77c12641a3fc7bb4c92a45e383486aa2 355 SUPERFAMILY SSF53098 171 326 1.63E-17 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15700 77c12641a3fc7bb4c92a45e383486aa2 355 SUPERFAMILY SSF46689 75 148 8.42E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15700 77c12641a3fc7bb4c92a45e383486aa2 355 Pfam PF13565 Homeodomain-like domain 92 146 1.1E-8 T 17-03-2017 SHXM_RS15700 77c12641a3fc7bb4c92a45e383486aa2 355 Gene3D G3DSA:3.30.420.10 168 324 1.1E-14 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS27940 59ddecb898713acdadece482041a05bd 200 SUPERFAMILY SSF53335 1 193 1.82E-39 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS27940 59ddecb898713acdadece482041a05bd 200 Gene3D G3DSA:3.40.50.150 18 199 5.8E-36 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS27940 59ddecb898713acdadece482041a05bd 200 Pfam PF13649 Methyltransferase domain 38 129 1.1E-16 T 17-03-2017 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 SMART SM00388 196 262 2.3E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 SUPERFAMILY SSF55874 253 415 1.22E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 PRINTS PR00344 Bacterial sensor protein C-terminal signature 377 395 1.5E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 PRINTS PR00344 Bacterial sensor protein C-terminal signature 401 414 1.5E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 PRINTS PR00344 Bacterial sensor protein C-terminal signature 360 370 1.5E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 Gene3D G3DSA:1.10.287.130 186 258 4.2E-10 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 SUPERFAMILY SSF158472 143 192 1.44E-8 T 17-03-2017 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 SMART SM00387 304 415 3.8E-24 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 308 414 4.3E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 Pfam PF00672 HAMP domain 123 191 4.8E-14 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 SUPERFAMILY SSF47384 179 261 1.04E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 Gene3D G3DSA:3.30.565.10 265 415 9.1E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 Pfam PF00512 His Kinase A (phospho-acceptor) domain 197 261 6.9E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37605 c9c5dbf5936f215b85fb62ddb269ed33 415 SMART SM00304 142 195 2.4E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 ProSitePatterns PS00455 Putative AMP-binding domain signature. 608 619 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Pfam PF00668 Condensation domain 7 301 3.4E-54 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Pfam PF00550 Phosphopantetheine attachment site 984 1045 2.3E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SUPERFAMILY SSF47336 974 1047 2.22E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SUPERFAMILY SSF56801 428 993 2.62E-161 T 17-03-2017 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SUPERFAMILY SSF53474 1048 1309 1.11E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:3.40.50.1820 1053 1173 9.6E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:3.40.50.1820 1243 1311 9.6E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:1.10.1200.10 985 1051 1.4E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SUPERFAMILY SSF52777 191 428 3.89E-41 T 17-03-2017 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SMART SM00824 Thioesterase 1071 1305 3.0E-6 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 486 897 2.0E-131 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:3.40.50.980 617 774 6.0E-45 T 17-03-2017 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Pfam PF13193 AMP-binding enzyme C-terminal domain 881 956 5.6E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:3.40.50.980 458 616 1.3E-50 T 17-03-2017 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SUPERFAMILY SSF52777 11 184 2.89E-42 T 17-03-2017 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Pfam PF00975 Thioesterase domain 1069 1174 7.0E-28 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 SMART SM00823 Phosphopantetheine attachment site 981 1050 1.9E-5 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Pfam PF00501 AMP-binding enzyme 465 873 8.5E-97 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:3.30.300.30 869 984 3.5E-39 T 17-03-2017 SHXM_RS37820 c984fabd8b5274d4b5e835f0d7cfe2a7 1324 Gene3D G3DSA:2.30.38.10 784 863 3.4E-24 T 17-03-2017 SHXM_RS02895 05f9269ff61c5be7918bbe1c368a092c 408 Pfam PF00266 Aminotransferase class-V 22 391 1.9E-57 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS02895 05f9269ff61c5be7918bbe1c368a092c 408 Gene3D G3DSA:3.90.1150.10 262 401 1.8E-25 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS02895 05f9269ff61c5be7918bbe1c368a092c 408 TIGRFAM TIGR01976 am_tr_V_VC1184: cysteine desulfurase family protein 3 395 1.5E-149 T 17-03-2017 IPR011340 Cysteine desulfurase-related SHXM_RS02895 05f9269ff61c5be7918bbe1c368a092c 408 Gene3D G3DSA:3.40.640.10 33 261 1.1E-54 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS02895 05f9269ff61c5be7918bbe1c368a092c 408 SUPERFAMILY SSF53383 3 400 7.47E-85 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 SUPERFAMILY SSF53738 530 634 1.69E-14 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 384 511 3.8E-13 T 17-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 532 632 5.1E-16 T 17-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Gene3D G3DSA:3.40.120.10 552 627 1.3E-11 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Gene3D G3DSA:2.160.10.10 235 366 6.1E-27 T 17-03-2017 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Gene3D G3DSA:3.40.120.10 633 726 4.1E-14 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 SUPERFAMILY SSF53448 269 325 4.98E-80 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 SUPERFAMILY SSF53448 1 237 4.98E-80 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 SUPERFAMILY SSF55957 744 828 1.1E-11 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Gene3D G3DSA:3.90.550.10 1 234 1.2E-75 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 SUPERFAMILY SSF51161 244 431 1.99E-32 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Gene3D G3DSA:3.30.310.50 750 828 1.7E-11 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 638 740 7.1E-6 T 17-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Gene3D G3DSA:3.40.120.10 384 510 1.1E-11 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 268 301 5.4E-4 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 SUPERFAMILY SSF53738 637 741 7.85E-12 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS43915 a064abbf7255a1ba9111118f089cd112 831 Pfam PF00483 Nucleotidyl transferase 2 233 1.5E-52 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS16735 bdaa53a30cd81ec065574f5a2717af48 430 Gene3D G3DSA:1.20.1290.10 40 181 1.6E-24 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS16735 bdaa53a30cd81ec065574f5a2717af48 430 SUPERFAMILY SSF69118 38 184 7.59E-30 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS16735 bdaa53a30cd81ec065574f5a2717af48 430 Pfam PF02627 Carboxymuconolactone decarboxylase family 56 128 5.0E-7 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS08420 417a657480bdd3a1af90a22860d2cc5e 216 Pfam PF03029 Conserved hypothetical ATP binding protein 39 205 2.5E-22 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS08420 417a657480bdd3a1af90a22860d2cc5e 216 SUPERFAMILY SSF52540 35 207 1.49E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08420 417a657480bdd3a1af90a22860d2cc5e 216 PRINTS PR00449 Transforming protein P21 ras signature 35 56 2.3E-6 T 17-03-2017 SHXM_RS08420 417a657480bdd3a1af90a22860d2cc5e 216 PRINTS PR00449 Transforming protein P21 ras signature 93 115 2.3E-6 T 17-03-2017 SHXM_RS08420 417a657480bdd3a1af90a22860d2cc5e 216 PRINTS PR00449 Transforming protein P21 ras signature 183 205 2.3E-6 T 17-03-2017 SHXM_RS08420 417a657480bdd3a1af90a22860d2cc5e 216 Gene3D G3DSA:3.40.50.300 33 205 2.9E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 206 223 2.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 14 31 2.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 204 2.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 100 111 2.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 SUPERFAMILY SSF51735 7 254 2.59E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 Gene3D G3DSA:3.40.50.720 7 271 7.6E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05695 b981ffb1197f02dae91c51b1d3dc499b 308 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 228 3.6E-15 T 17-03-2017 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 Gene3D G3DSA:1.10.1200.10 424 500 2.0E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 SUPERFAMILY SSF55048 131 195 5.36E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 Pfam PF00698 Acyl transferase domain 53 218 4.1E-20 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 SUPERFAMILY SSF47336 422 499 1.01E-7 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 ProSitePatterns PS00012 Phosphopantetheine attachment site. 454 469 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 SUPERFAMILY SSF52151 4 132 3.66E-31 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 SUPERFAMILY SSF52151 197 293 3.66E-31 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 Pfam PF00550 Phosphopantetheine attachment site 429 494 3.1E-5 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 Gene3D G3DSA:3.40.366.10 196 294 4.5E-30 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 Gene3D G3DSA:3.40.366.10 4 126 4.5E-30 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 Gene3D G3DSA:3.30.70.250 131 195 4.0E-4 T 17-03-2017 SHXM_RS03070 d164cc4bd22cedac4ca7bfc599d45e9e 506 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 18 301 4.3E-16 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 SUPERFAMILY SSF52172 3 63 4.83E-8 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 Pfam PF00072 Response regulator receiver domain 6 69 1.0E-5 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 Gene3D G3DSA:3.40.50.2300 3 64 1.3E-36 T 17-03-2017 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 Gene3D G3DSA:3.40.50.2300 113 206 1.3E-36 T 17-03-2017 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 SUPERFAMILY SSF52172 114 182 9.25E-8 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 Pfam PF00196 Bacterial regulatory proteins, luxR family 207 262 1.1E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 SUPERFAMILY SSF46894 198 267 4.08E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 Gene3D G3DSA:1.10.10.10 207 267 1.5E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 238 250 1.2E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 208 222 1.2E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 222 238 1.2E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 SMART SM00448 4 169 1.2E-8 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS32730 473ff16d3b7e0bc01cec277e976d4fc0 284 SMART SM00421 205 262 2.1E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46570 b3544a487d0a59f23585488eafd01b1b 200 Gene3D G3DSA:3.40.47.10 27 147 1.4E-6 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46570 b3544a487d0a59f23585488eafd01b1b 200 SUPERFAMILY SSF53901 25 148 1.41E-8 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 Gene3D G3DSA:3.20.20.80 45 337 3.0E-64 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 Pfam PF00553 Cellulose binding domain 347 447 7.5E-27 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 SUPERFAMILY SSF51445 44 337 4.22E-67 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 Gene3D G3DSA:2.60.40.290 345 448 4.1E-34 T 17-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 SUPERFAMILY SSF49384 344 448 4.81E-30 T 17-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 SMART SM00637 347 447 1.3E-39 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS05680 426940b6db7193c7bd06fca8dc899514 450 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 54 299 4.8E-34 T 17-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SHXM_RS41180 a9c19a0b896fc43f862d87d46e31a8ef 192 Gene3D G3DSA:1.10.357.10 6 186 7.7E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41180 a9c19a0b896fc43f862d87d46e31a8ef 192 SUPERFAMILY SSF46689 7 78 7.98E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41180 a9c19a0b896fc43f862d87d46e31a8ef 192 SUPERFAMILY SSF48498 84 187 9.22E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41180 a9c19a0b896fc43f862d87d46e31a8ef 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 63 1.8E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13070 ffc0d4cac1bb71db1fd7f6f181ace491 57 SUPERFAMILY SSF47413 3 52 1.13E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13070 ffc0d4cac1bb71db1fd7f6f181ace491 57 SMART SM00530 1 56 0.0054 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS13070 ffc0d4cac1bb71db1fd7f6f181ace491 57 Pfam PF13560 Helix-turn-helix domain 2 53 7.0E-12 T 17-03-2017 SHXM_RS13070 ffc0d4cac1bb71db1fd7f6f181ace491 57 Gene3D G3DSA:1.10.260.40 5 52 7.0E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35210 11b9c81c7565b7ca1e246a9941906637 219 SUPERFAMILY SSF52788 182 210 4.58E-22 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS35210 11b9c81c7565b7ca1e246a9941906637 219 SUPERFAMILY SSF52788 20 143 4.58E-22 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS35210 11b9c81c7565b7ca1e246a9941906637 219 SMART SM00226 21 211 5.7E-6 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS35210 11b9c81c7565b7ca1e246a9941906637 219 Gene3D G3DSA:3.40.50.270 175 212 2.4E-30 T 17-03-2017 SHXM_RS35210 11b9c81c7565b7ca1e246a9941906637 219 Gene3D G3DSA:3.40.50.270 21 134 2.4E-30 T 17-03-2017 SHXM_RS35210 11b9c81c7565b7ca1e246a9941906637 219 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 23 152 8.1E-15 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS49820 fc6ce7d1fd9f5a48f5a74673cdf5e110 268 SUPERFAMILY SSF161098 66 252 3.01E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49820 fc6ce7d1fd9f5a48f5a74673cdf5e110 268 Gene3D G3DSA:1.10.3720.10 64 260 1.8E-7 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49820 fc6ce7d1fd9f5a48f5a74673cdf5e110 268 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 80 254 5.2E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 Gene3D G3DSA:3.30.499.10 31 161 7.1E-40 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 SUPERFAMILY SSF53732 10 423 6.15E-122 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 Pfam PF00330 Aconitase family (aconitate hydratase) 30 414 1.7E-82 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 PRINTS PR00415 Aconitase family signature 117 130 6.6E-18 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 PRINTS PR00415 Aconitase family signature 131 146 6.6E-18 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 PRINTS PR00415 Aconitase family signature 356 369 6.6E-18 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 PRINTS PR00415 Aconitase family signature 193 206 6.6E-18 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 PRINTS PR00415 Aconitase family signature 274 288 6.6E-18 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 SUPERFAMILY SSF52016 451 657 1.29E-51 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 Gene3D G3DSA:3.30.499.10 278 472 5.2E-44 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 Gene3D G3DSA:3.20.19.10 473 657 9.8E-47 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 TIGRFAM TIGR01342 acon_putative: putative aconitate hydratase 11 653 2.5E-234 T 17-03-2017 IPR006250 Aconitase, putative SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 Gene3D G3DSA:3.40.1060.10 165 269 1.1E-28 T 17-03-2017 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS42570 754470636a9f267a878b9e13dd790533 660 Pfam PF00694 Aconitase C-terminal domain 523 591 4.4E-23 T 17-03-2017 IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 165 0.0036 T 17-03-2017 SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 166 6.4E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 73 84 6.4E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 6.4E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 121 137 6.4E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 185 6.4E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 6.4E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 Gene3D G3DSA:3.40.50.720 6 248 1.2E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 73 84 2.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 127 135 2.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 147 166 2.5E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 248 1.3E-55 T 17-03-2017 SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 134 162 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS39345 ae02e27e079c8a5aeb28cdd880e902eb 254 SUPERFAMILY SSF51735 6 249 1.14E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 309 323 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 445 460 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 498 514 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 273 293 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 222 237 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 387 409 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 337 352 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PRINTS PR00743 Glycosyl hydrolase family 36 signature 523 539 1.9E-51 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 ProSitePatterns PS00512 Alpha-galactosidase signature. 338 354 - T 17-03-2017 IPR000111 Glycoside hydrolase family 27/36, conserved site GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 Pfam PF02065 Melibiase 271 613 9.6E-117 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 Gene3D G3DSA:3.20.20.70 306 595 1.5E-46 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 Pfam PF16874 Glycosyl hydrolase family 36 C-terminal domain 627 703 4.6E-10 T 17-03-2017 IPR031705 Glycosyl hydrolase family 36, C-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 Pfam PF16875 Glycosyl hydrolase family 36 N-terminal domain 30 265 1.1E-55 T 17-03-2017 IPR031704 Glycosyl hydrolase family 36, N-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 PIRSF PIRSF005536 3 699 2.3E-184 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS46420 a03be8a4e94131ac4750360a65521e3f 711 SUPERFAMILY SSF51445 307 642 2.08E-93 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 3 167 2.4E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 PIRSF PIRSF000362 1 446 2.5E-145 T 17-03-2017 IPR021163 Ferredoxin-NADP+ reductase, adrenodoxin-type GO:0016491|GO:0055114 Reactome: R-HSA-196108|Reactome: R-HSA-211976|Reactome: R-HSA-2395516|Reactome: R-HSA-5579026 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 SUPERFAMILY SSF51971 308 435 4.59E-7 T 17-03-2017 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 SUPERFAMILY SSF51971 261 317 3.53E-48 T 17-03-2017 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 SUPERFAMILY SSF51971 3 212 3.53E-48 T 17-03-2017 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 PRINTS PR00419 Adrenodoxin reductase family signature 3 25 4.2E-11 T 17-03-2017 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 PRINTS PR00419 Adrenodoxin reductase family signature 146 160 4.2E-11 T 17-03-2017 SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 Gene3D G3DSA:3.40.50.720 317 440 4.4E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 Gene3D G3DSA:3.40.50.720 2 96 4.4E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42765 ce489a5e0448d7302241c99c710b83fb 447 Gene3D G3DSA:3.50.50.60 97 316 3.6E-66 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27695 99a06e45c32fea8e09270372f826d2fb 149 Pfam PF09056 Prokaryotic phospholipase A2 45 149 1.5E-34 T 17-03-2017 IPR015141 Phospholipase A2, prokaryotic/fungal SHXM_RS27695 99a06e45c32fea8e09270372f826d2fb 149 Gene3D G3DSA:1.20.90.10 30 149 4.7E-43 T 17-03-2017 IPR016090 Phospholipase A2 domain KEGG: 00564+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SHXM_RS27695 99a06e45c32fea8e09270372f826d2fb 149 SUPERFAMILY SSF48619 29 149 1.14E-39 T 17-03-2017 IPR016090 Phospholipase A2 domain KEGG: 00564+3.1.1.4|KEGG: 00565+3.1.1.4|KEGG: 00590+3.1.1.4|KEGG: 00591+3.1.1.4|KEGG: 00592+3.1.1.4|MetaCyc: PWY-6803|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7417 SHXM_RS21085 25094c69ee31739aa4f3f56bc2ad6673 278 Gene3D G3DSA:3.40.1180.10 32 263 7.4E-91 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS21085 25094c69ee31739aa4f3f56bc2ad6673 278 Pfam PF01255 Putative undecaprenyl diphosphate synthase 41 261 3.7E-74 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS21085 25094c69ee31739aa4f3f56bc2ad6673 278 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 34 261 3.9E-79 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS21085 25094c69ee31739aa4f3f56bc2ad6673 278 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 34 262 38.381 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS21085 25094c69ee31739aa4f3f56bc2ad6673 278 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 207 224 - T 17-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 SHXM_RS21085 25094c69ee31739aa4f3f56bc2ad6673 278 SUPERFAMILY SSF64005 34 257 2.22E-84 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 Pfam PF00403 Heavy-metal-associated domain 30 90 7.8E-14 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 Gene3D G3DSA:3.30.70.100 28 91 3.6E-19 T 17-03-2017 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 PRINTS PR00944 Copper ion binding protein signature 28 40 8.9E-6 T 17-03-2017 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 PRINTS PR00944 Copper ion binding protein signature 40 53 8.9E-6 T 17-03-2017 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 PRINTS PR00944 Copper ion binding protein signature 78 91 8.9E-6 T 17-03-2017 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 PRINTS PR00944 Copper ion binding protein signature 66 78 8.9E-6 T 17-03-2017 IPR000428 Copper ion binding protein GO:0005507|GO:0006825 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 SUPERFAMILY SSF55008 22 92 1.1E-15 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS22305 3bf3f45b818c0045451e2ab75fe5890f 96 ProSitePatterns PS01047 Heavy-metal-associated domain. 33 63 - T 17-03-2017 IPR017969 Heavy-metal-associated, conserved site GO:0030001|GO:0046872 SHXM_RS32385 17a2d42e08fd46b3026cfa430fca6a55 191 Gene3D G3DSA:3.40.50.980 29 173 1.5E-18 T 17-03-2017 SHXM_RS32385 17a2d42e08fd46b3026cfa430fca6a55 191 SUPERFAMILY SSF56801 28 187 8.11E-31 T 17-03-2017 SHXM_RS32385 17a2d42e08fd46b3026cfa430fca6a55 191 Pfam PF00501 AMP-binding enzyme 28 134 2.9E-17 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 SUPERFAMILY SSF56645 77 292 1.18E-40 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Pfam PF12806 Acetyl-CoA dehydrogenase C-terminal like 473 604 5.0E-30 T 17-03-2017 IPR025878 Acetyl-CoA dehydrogenase-like C-terminal domain SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 SUPERFAMILY SSF47203 290 469 4.03E-32 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 162 271 4.1E-18 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Gene3D G3DSA:1.20.140.10 273 466 2.6E-39 T 17-03-2017 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Pfam PF12418 Acyl-CoA dehydrogenase N terminal 3 34 4.4E-10 T 17-03-2017 IPR020953 Acyl-CoA dehydrogenase, N-terminal, bacteria SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Gene3D G3DSA:2.40.110.10 161 272 1.1E-24 T 17-03-2017 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Gene3D G3DSA:1.10.540.10 36 146 1.1E-4 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS28505 43e82d7f20d7f2ec602d6b810ac4d3e3 608 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 286 452 4.7E-16 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS27265 21b391743481e7549c6c3474f75d8ef4 767 SUPERFAMILY SSF48576 392 722 2.13E-60 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS27265 21b391743481e7549c6c3474f75d8ef4 767 Gene3D G3DSA:1.10.600.10 392 712 4.0E-98 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS27265 21b391743481e7549c6c3474f75d8ef4 767 Gene3D G3DSA:1.10.600.10 1 317 5.0E-105 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS27265 21b391743481e7549c6c3474f75d8ef4 767 SUPERFAMILY SSF48576 1 323 4.6E-66 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 SMART SM01130 6 309 8.8E-78 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 SUPERFAMILY SSF51569 3 311 7.54E-72 T 17-03-2017 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 ProSitePatterns PS00666 Dihydrodipicolinate synthase signature 2. 138 168 - T 17-03-2017 IPR020625 Schiff base-forming aldolase, active site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 Pfam PF00701 Dihydrodipicolinate synthetase family 7 306 2.6E-43 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 PIRSF PIRSF001365 4 311 2.0E-69 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 Gene3D G3DSA:3.20.20.70 6 311 1.8E-80 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 133 150 4.9E-8 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 108 124 4.9E-8 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 76 94 4.9E-8 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS13545 bc34aaac60711e1b5952eb39463f65cf 312 PRINTS PR00146 Dihydrodipicolinate synthase signature 40 61 4.9E-8 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 Gene3D G3DSA:3.40.50.300 362 610 4.4E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 SUPERFAMILY SSF52540 361 617 2.13E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 SMART SM00382 406 592 4.0E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 SUPERFAMILY SSF90123 27 350 1.19E-72 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 Pfam PF00005 ABC transporter 397 546 3.6E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 Gene3D G3DSA:1.20.1560.10 30 350 1.6E-72 T 17-03-2017 SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 ProSitePatterns PS00211 ABC transporters family signature. 518 532 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS12295 34ab9e026b093ace2d3e51bf712ae573 671 Pfam PF00664 ABC transporter transmembrane region 45 314 9.9E-42 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS31665 fc9dfabd93304cbca10b4e590ac4c47c 488 SUPERFAMILY SSF53720 2 484 3.27E-152 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS31665 fc9dfabd93304cbca10b4e590ac4c47c 488 Gene3D G3DSA:3.40.605.10 3 269 7.6E-85 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS31665 fc9dfabd93304cbca10b4e590ac4c47c 488 Gene3D G3DSA:3.40.309.10 270 459 1.0E-61 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS31665 fc9dfabd93304cbca10b4e590ac4c47c 488 Pfam PF00171 Aldehyde dehydrogenase family 13 483 5.2E-156 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36115 a9a66c381ed0b99925490ad752561239 760 SUPERFAMILY SSF82866 481 701 2.88E-24 T 17-03-2017 SHXM_RS36115 a9a66c381ed0b99925490ad752561239 760 Pfam PF03176 MMPL family 478 701 1.6E-26 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS36115 a9a66c381ed0b99925490ad752561239 760 Pfam PF03176 MMPL family 42 372 1.1E-64 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS36115 a9a66c381ed0b99925490ad752561239 760 SUPERFAMILY SSF82866 135 335 1.11E-28 T 17-03-2017 SHXM_RS36115 a9a66c381ed0b99925490ad752561239 760 Gene3D G3DSA:1.20.1640.10 143 343 1.9E-29 T 17-03-2017 SHXM_RS36115 a9a66c381ed0b99925490ad752561239 760 Gene3D G3DSA:1.20.1640.10 503 707 1.4E-26 T 17-03-2017 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 153 171 1.7E-16 T 17-03-2017 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 262 284 1.7E-16 T 17-03-2017 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 111 129 1.7E-16 T 17-03-2017 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 16 35 1.7E-16 T 17-03-2017 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 SUPERFAMILY SSF51905 10 306 1.46E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 Gene3D G3DSA:3.50.50.60 137 236 1.3E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 Gene3D G3DSA:3.50.50.60 13 136 4.2E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 Gene3D G3DSA:3.50.50.60 261 308 4.2E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 134 146 9.2E-19 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 15 37 9.2E-19 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 272 290 9.2E-19 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 149 173 9.2E-19 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 112 120 9.2E-19 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS05085 34a17b6106ee52c2161173de28f157da 347 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 14 296 5.1E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42055 5f33834fac3d203beef82a1363da24eb 284 Pfam PF08223 PaaX-like protein C-terminal domain 106 269 8.0E-52 T 17-03-2017 IPR013225 PaaX-like, C-terminal SHXM_RS42055 5f33834fac3d203beef82a1363da24eb 284 PIRSF PIRSF020623 1 284 1.7E-77 T 17-03-2017 IPR011965 Phenylacetic acid degradation operon negative regulatory protein PaaX GO:0006351 SHXM_RS42055 5f33834fac3d203beef82a1363da24eb 284 Pfam PF07848 PaaX-like protein 22 86 3.6E-13 T 17-03-2017 IPR012906 PaaX-like, N-terminal SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF51735 2755 2995 5.76E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 574 873 6.4E-119 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2118 2417 1.6E-121 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00825 Beta-ketoacyl synthase 37 463 1.0E-223 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00825 Beta-ketoacyl synthase 1588 2014 4.8E-224 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF51735 1207 1433 1.01E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF00550 Phosphopantetheine attachment site 3049 3115 6.4E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF00550 Phosphopantetheine attachment site 1495 1561 5.9E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:1.10.1200.10 3046 3119 2.8E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:1.10.1200.10 1491 1567 1.4E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF53901 1582 1960 3.67E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF08990 Erythronolide synthase docking 4 28 1.6E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM01294 3048 3115 9.2E-5 T 17-03-2017 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM01294 1494 1561 6.3E-7 T 17-03-2017 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 198 214 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF55048 2242 2308 1.19E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 4.3E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1844 1961 6.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22150 494146f9652598d18a271042216d427a 3205 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3074 3089 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.50.720 1208 1389 2.1E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.50.720 2757 2979 4.7E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF00698 Acyl transferase domain 573 890 1.5E-86 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF00698 Acyl transferase domain 2117 2435 4.9E-88 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22150 494146f9652598d18a271042216d427a 3205 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1749 1765 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.30.70.250 2241 2307 1.5E-8 T 17-03-2017 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.30.70.250 697 763 6.6E-8 T 17-03-2017 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF08659 KR domain 2757 2934 2.9E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF08659 KR domain 1208 1385 1.4E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF55048 698 764 1.44E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1208 1387 3.1E-63 T 17-03-2017 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2757 2936 1.0E-57 T 17-03-2017 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF53901 31 408 8.2E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00823 Phosphopantetheine attachment site 1493 1565 7.4E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SMART SM00823 Phosphopantetheine attachment site 3047 3119 5.0E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.47.10 1584 1848 9.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF51735 983 1195 9.84E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.366.10 2308 2418 5.6E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.366.10 764 874 1.6E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.366.10 570 693 1.6E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.366.10 2115 2237 5.6E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1964 2080 3.3E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 535 3.7E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF52151 570 699 1.36E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF52151 765 862 1.36E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF52151 2309 2405 4.71E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF52151 2115 2243 4.71E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.47.10 1849 2015 3.5E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.47.10 298 465 1.3E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Gene3D G3DSA:3.40.47.10 37 297 4.6E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF47336 1489 1601 1.96E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1520 1535 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF51735 2532 2744 3.68E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 8.8E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22150 494146f9652598d18a271042216d427a 3205 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1586 1836 9.5E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF101173 4 35 7.85E-7 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22150 494146f9652598d18a271042216d427a 3205 SUPERFAMILY SSF47336 3045 3128 6.54E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 Gene3D G3DSA:3.40.50.1820 2 310 2.4E-84 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 SUPERFAMILY SSF53474 2 175 1.59E-72 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 SUPERFAMILY SSF53474 202 309 1.59E-72 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 PRINTS PR00412 Epoxide hydrolase signature 44 59 9.6E-30 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 PRINTS PR00412 Epoxide hydrolase signature 247 263 9.6E-30 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 PRINTS PR00412 Epoxide hydrolase signature 90 103 9.6E-30 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 PRINTS PR00412 Epoxide hydrolase signature 104 117 9.6E-30 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 PRINTS PR00412 Epoxide hydrolase signature 24 42 9.6E-30 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 PRINTS PR00412 Epoxide hydrolase signature 286 308 9.6E-30 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS10595 90237fe93e8b53bc9ba5915048423aca 313 Pfam PF00561 alpha/beta hydrolase fold 18 297 3.6E-24 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 SUPERFAMILY SSF158472 271 319 2.48E-6 T 17-03-2017 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 Pfam PF00512 His Kinase A (phospho-acceptor) domain 331 398 3.2E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 SMART SM00388 331 398 9.5E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 PRINTS PR00344 Bacterial sensor protein C-terminal signature 480 494 4.0E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 PRINTS PR00344 Bacterial sensor protein C-terminal signature 515 533 4.0E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 PRINTS PR00344 Bacterial sensor protein C-terminal signature 539 552 4.0E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 PRINTS PR00344 Bacterial sensor protein C-terminal signature 498 508 4.0E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 Gene3D G3DSA:3.30.565.10 401 554 1.6E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 445 554 2.0E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 SUPERFAMILY SSF47384 314 398 3.34E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 Gene3D G3DSA:1.10.287.130 322 394 5.4E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 Pfam PF00672 HAMP domain 252 319 8.9E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 SUPERFAMILY SSF55874 387 556 5.37E-40 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 SMART SM00387 444 555 8.1E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24115 af9210c2f05063de5ae097029b6f96fc 657 SMART SM00304 271 323 5.5E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 Pfam PF02627 Carboxymuconolactone decarboxylase family 330 411 7.1E-24 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 TIGRFAM TIGR02427 protocat_pcaD: 3-oxoadipate enol-lactonase 35 283 3.6E-77 T 17-03-2017 IPR026968 3-oxoadipate enol-lactonase 1/2 GO:0042952|GO:0047570 KEGG: 00362+3.1.1.24|MetaCyc: PWY-6185 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 SUPERFAMILY SSF69118 298 418 9.07E-34 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 Pfam PF00561 alpha/beta hydrolase fold 45 163 4.1E-14 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 Pfam PF08386 TAP-like protein 224 284 6.6E-7 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 Gene3D G3DSA:3.40.50.1820 35 284 4.1E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 PRINTS PR00111 Alpha/beta hydrolase fold signature 70 85 4.5E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 PRINTS PR00111 Alpha/beta hydrolase fold signature 118 131 4.5E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 PRINTS PR00111 Alpha/beta hydrolase fold signature 229 243 4.5E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 PRINTS PR00111 Alpha/beta hydrolase fold signature 132 145 4.5E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 Gene3D G3DSA:1.20.1290.10 299 418 2.1E-28 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 TIGRFAM TIGR02425 decarb_PcaC: 4-carboxymuconolactone decarboxylase 298 417 4.2E-50 T 17-03-2017 IPR012788 4-carboxymuconolactone decarboxylase KEGG: 00362+4.1.1.44 SHXM_RS20855 6b89480b38a916697258c92a9e310615 421 SUPERFAMILY SSF53474 32 284 1.52E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02725 8e23243c339fc7c5aa8d825aef9dd599 235 SUPERFAMILY SSF161111 18 202 1.18E-26 T 17-03-2017 SHXM_RS02725 8e23243c339fc7c5aa8d825aef9dd599 235 Pfam PF01545 Cation efflux family 28 201 1.4E-11 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS02725 8e23243c339fc7c5aa8d825aef9dd599 235 Gene3D G3DSA:1.20.1510.10 24 199 2.2E-14 T 17-03-2017 IPR027469 Cation efflux protein transmembrane domain SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 SUPERFAMILY SSF52540 163 413 1.2E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 SUPERFAMILY SSF140990 423 618 9.02E-75 T 17-03-2017 SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 Gene3D G3DSA:3.40.50.300 165 349 5.0E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 Gene3D G3DSA:1.10.8.60 350 416 1.6E-23 T 17-03-2017 SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 209 341 4.5E-45 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 Pfam PF01434 Peptidase family M41 406 611 3.2E-81 T 17-03-2017 IPR000642 Peptidase M41 GO:0004222|GO:0005524|GO:0006508 SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 ProSitePatterns PS00674 AAA-protein family signature. 312 330 - T 17-03-2017 IPR003960 ATPase, AAA-type, conserved site GO:0005524 SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 SMART SM00382 205 344 1.4E-24 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 TIGRFAM TIGR01241 FtsH_fam: ATP-dependent metallopeptidase HflB 122 612 1.5E-233 T 17-03-2017 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 SHXM_RS26450 4930965ea86c81f28f41f87b7e3c03e7 680 Hamap MF_01458 ATP-dependent zinc metalloprotease FtsH [ftsH]. 5 621 37.353 T 17-03-2017 IPR005936 Peptidase, FtsH GO:0004222|GO:0016020 SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 SUPERFAMILY SSF53067 75 371 1.4E-43 T 17-03-2017 SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 Gene3D G3DSA:3.30.420.40 214 351 3.6E-19 T 17-03-2017 SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 Gene3D G3DSA:3.30.420.40 71 213 1.6E-41 T 17-03-2017 SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 Gene3D G3DSA:1.10.10.10 6 68 1.3E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 Pfam PF13412 Winged helix-turn-helix DNA-binding 9 48 1.7E-6 T 17-03-2017 SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 Pfam PF00480 ROK family 84 369 3.8E-33 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS01470 2b12387949310a9530230c632cb4bb32 405 SUPERFAMILY SSF46785 3 64 3.89E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37905 5f25bcf14f18909bcfab2e760daca99c 721 Gene3D G3DSA:1.20.1640.10 132 348 8.4E-36 T 17-03-2017 SHXM_RS37905 5f25bcf14f18909bcfab2e760daca99c 721 Gene3D G3DSA:1.20.1640.10 481 695 1.2E-31 T 17-03-2017 SHXM_RS37905 5f25bcf14f18909bcfab2e760daca99c 721 SUPERFAMILY SSF82866 137 343 1.31E-33 T 17-03-2017 SHXM_RS37905 5f25bcf14f18909bcfab2e760daca99c 721 SUPERFAMILY SSF82866 483 691 2.75E-33 T 17-03-2017 SHXM_RS37905 5f25bcf14f18909bcfab2e760daca99c 721 Pfam PF03176 MMPL family 43 368 9.0E-61 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS37905 5f25bcf14f18909bcfab2e760daca99c 721 Pfam PF03176 MMPL family 398 696 4.9E-53 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS14400 7118cc849a6602836ac9621092fe1b8d 237 Gene3D G3DSA:3.40.50.300 41 104 1.9E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14400 7118cc849a6602836ac9621092fe1b8d 237 SMART SM00382 38 206 4.5E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14400 7118cc849a6602836ac9621092fe1b8d 237 SUPERFAMILY SSF52540 35 206 5.84E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14400 7118cc849a6602836ac9621092fe1b8d 237 Gene3D G3DSA:3.40.50.300 144 207 7.2E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14400 7118cc849a6602836ac9621092fe1b8d 237 Gene3D G3DSA:3.40.50.300 110 143 6.4E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14400 7118cc849a6602836ac9621092fe1b8d 237 Pfam PF13304 AAA domain, putative AbiEii toxin, Type IV TA system 147 192 1.1E-6 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 SUPERFAMILY SSF47413 10 71 7.04E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 Pfam PF13560 Helix-turn-helix domain 12 69 5.8E-12 T 17-03-2017 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 SMART SM00530 15 70 4.6E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 Gene3D G3DSA:1.25.40.10 157 374 1.5E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 SUPERFAMILY SSF48452 163 286 2.66E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 SUPERFAMILY SSF48452 331 373 2.66E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22440 7d9e91c94fab8af06898d47d9e92fb2e 400 Gene3D G3DSA:1.10.260.40 12 75 1.0E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS14910 158c05fb544446487a1c49fb47f4bc26 259 ProSitePatterns PS00211 ABC transporters family signature. 141 155 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS14910 158c05fb544446487a1c49fb47f4bc26 259 SMART SM00382 34 218 6.1E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14910 158c05fb544446487a1c49fb47f4bc26 259 Gene3D G3DSA:3.40.50.300 2 235 3.4E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14910 158c05fb544446487a1c49fb47f4bc26 259 Pfam PF00005 ABC transporter 26 168 1.2E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS14910 158c05fb544446487a1c49fb47f4bc26 259 SUPERFAMILY SSF52540 5 231 1.13E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00930 bcc97783626125c17d54c8afe3ee0df2 136 SUPERFAMILY SSF54427 3 109 1.11E-18 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS00930 bcc97783626125c17d54c8afe3ee0df2 136 Pfam PF12680 SnoaL-like domain 10 102 4.9E-15 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS00930 bcc97783626125c17d54c8afe3ee0df2 136 Gene3D G3DSA:3.10.450.50 2 107 2.4E-16 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1042 1290 4.6E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2097 2346 2.6E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 16 263 4.5E-77 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00825 Beta-ketoacyl synthase 1044 1468 2.7E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00825 Beta-ketoacyl synthase 17 441 2.6E-191 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00825 Beta-ketoacyl synthase 2099 2524 3.7E-210 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.366.10 560 690 1.7E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.366.10 757 874 1.7E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.30.70.250 697 750 2.5E-6 T 17-03-2017 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.30.70.250 1709 1770 1.7E-6 T 17-03-2017 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.30.70.250 2752 2815 5.8E-7 T 17-03-2017 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2354 2471 9.9E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1298 1415 7.7E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 272 388 1.7E-37 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2007 2022 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF55048 2752 2816 1.09E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00698 Acyl transferase domain 2626 2925 7.4E-82 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00698 Acyl transferase domain 1581 1899 1.2E-81 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00698 Acyl transferase domain 568 879 1.3E-76 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00550 Phosphopantetheine attachment site 1982 2048 2.2E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF00550 Phosphopantetheine attachment site 948 1014 1.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF53901 2094 2469 7.51E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.366.10 1581 1702 4.1E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.366.10 2816 2908 6.6E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.366.10 2626 2747 6.6E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.366.10 1771 1880 4.1E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.47.10 2099 2358 7.5E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.47.10 1044 1302 1.2E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00823 Phosphopantetheine attachment site 1980 2052 3.4E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00823 Phosphopantetheine attachment site 946 1018 1.7E-24 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF55048 693 753 4.45E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF47336 1974 2061 3.01E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF52151 1772 1869 2.56E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF52151 1581 1708 2.56E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF53901 1039 1413 3.28E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2474 2589 1.2E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1418 1542 7.1E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 391 531 1.2E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2259 2275 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 570 860 1.4E-111 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2628 2989 1.3E-116 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1583 1880 2.2E-115 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF47336 945 1057 2.22E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF52151 568 695 9.42E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF52151 758 848 9.42E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1203 1219 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF53901 416 435 2.81E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF53901 11 381 2.81E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:1.10.1200.10 1980 2053 2.6E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:1.10.1200.10 945 1017 2.8E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.47.10 276 440 8.1E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.47.10 2359 2525 2.5E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.47.10 1303 1468 5.5E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF55048 1709 1771 2.09E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM01294 1981 2048 6.5E-6 T 17-03-2017 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SMART SM01294 947 1014 3.3E-4 T 17-03-2017 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF52151 2626 2753 2.22E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 SUPERFAMILY SSF52151 2817 2909 2.22E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS38785 3eec3090459628b52fe971b8ae4dfe09 3072 Gene3D G3DSA:3.40.47.10 14 275 8.9E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 TIGRFAM TIGR00759 aceE: pyruvate dehydrogenase (acetyl-transferring), homodimeric type 15 891 0.0 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 PIRSF PIRSF000156 6 891 0.0 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 Gene3D G3DSA:3.40.50.920 720 891 1.8E-65 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 SUPERFAMILY SSF52922 717 891 1.05E-50 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 SUPERFAMILY SSF52518 484 711 2.0E-88 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 147 299 3.5E-10 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 SUPERFAMILY SSF52518 67 477 2.64E-113 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 Gene3D G3DSA:3.40.50.970 484 716 3.5E-109 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS19025 7c8e888be4adba179ab6e22ae8c8b3b3 891 Gene3D G3DSA:3.40.50.970 67 478 4.2E-134 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 Pfam PF00501 AMP-binding enzyme 40 417 1.7E-65 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 Gene3D G3DSA:3.40.50.980 43 184 8.0E-31 T 17-03-2017 SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 Gene3D G3DSA:3.40.50.980 185 345 2.3E-29 T 17-03-2017 SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 ProSitePatterns PS00455 Putative AMP-binding domain signature. 178 189 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 Gene3D G3DSA:3.30.300.30 420 526 4.2E-25 T 17-03-2017 SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 Gene3D G3DSA:2.30.38.10 346 408 3.2E-7 T 17-03-2017 SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 Pfam PF13193 AMP-binding enzyme C-terminal domain 429 519 4.4E-18 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS06670 9083e2c68ead572373d2c909955e2299 530 SUPERFAMILY SSF56801 26 526 6.41E-116 T 17-03-2017 SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 Pfam PF00069 Protein kinase domain 15 266 4.6E-39 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 SUPERFAMILY SSF56112 11 271 9.59E-61 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 Gene3D G3DSA:1.10.510.10 98 266 1.1E-39 T 17-03-2017 SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 SMART SM00220 15 279 7.0E-41 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS29315 77104e49fddd7afb45ad5e8c36a4c44b 515 Gene3D G3DSA:3.30.200.20 9 89 3.8E-14 T 17-03-2017 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.30.365.10 128 185 3.7E-32 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.30.365.10 293 370 3.7E-32 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 SUPERFAMILY SSF56003 133 785 4.06E-178 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.30.365.10 186 289 1.4E-32 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.30.365.10 463 633 1.4E-43 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 25 139 1.7E-25 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.30.365.10 374 462 1.5E-55 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.30.365.10 637 785 1.5E-55 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 SMART SM01008 25 139 4.2E-45 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 156 722 8.7E-157 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 Gene3D G3DSA:3.90.1170.50 5 127 1.7E-40 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS01360 f48e591fb4668e915c00d06fbfac2873 790 SUPERFAMILY SSF54665 8 159 6.15E-43 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 62 1.5E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 Pfam PF13305 WHG domain 90 175 2.6E-17 T 17-03-2017 IPR025996 WHG domain SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 SUPERFAMILY SSF48498 85 189 7.07E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 Gene3D G3DSA:1.10.357.10 6 191 5.8E-41 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 SUPERFAMILY SSF46689 8 77 1.55E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 3.8E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS49145 412b3e6137230c02ea4f03baf05f6222 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 3.8E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42670 374ced1b8b05b18497c382b8129f1f19 139 SUPERFAMILY SSF111038 5 139 5.76E-32 T 17-03-2017 IPR001602 Uncharacterised protein family UPF0047 SHXM_RS42670 374ced1b8b05b18497c382b8129f1f19 139 PIRSF PIRSF004681 1 139 2.2E-26 T 17-03-2017 IPR001602 Uncharacterised protein family UPF0047 SHXM_RS42670 374ced1b8b05b18497c382b8129f1f19 139 Gene3D G3DSA:2.60.120.460 4 139 3.0E-30 T 17-03-2017 IPR001602 Uncharacterised protein family UPF0047 SHXM_RS42670 374ced1b8b05b18497c382b8129f1f19 139 Pfam PF01894 Uncharacterised protein family UPF0047 21 135 7.4E-22 T 17-03-2017 IPR001602 Uncharacterised protein family UPF0047 SHXM_RS30330 643f38d948fe4dddc7be1b4ad1b09229 281 Gene3D G3DSA:3.20.20.150 8 265 1.7E-47 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS30330 643f38d948fe4dddc7be1b4ad1b09229 281 Pfam PF01261 Xylose isomerase-like TIM barrel 29 215 5.6E-16 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS30330 643f38d948fe4dddc7be1b4ad1b09229 281 SUPERFAMILY SSF51658 8 266 2.07E-44 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS43115 745178337560960aeeffd29d18750254 243 Pfam PF01553 Acyltransferase 24 149 7.2E-29 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS43115 745178337560960aeeffd29d18750254 243 SMART SM00563 38 152 1.7E-35 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS43115 745178337560960aeeffd29d18750254 243 Gene3D G3DSA:3.40.1130.10 27 207 3.0E-26 T 17-03-2017 SHXM_RS43115 745178337560960aeeffd29d18750254 243 SUPERFAMILY SSF69593 18 205 9.55E-40 T 17-03-2017 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 SUPERFAMILY SSF52283 406 485 3.8E-115 T 17-03-2017 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 SUPERFAMILY SSF52283 8 157 3.8E-115 T 17-03-2017 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 SUPERFAMILY SSF52283 195 242 3.8E-115 T 17-03-2017 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 Pfam PF05221 S-adenosyl-L-homocysteine hydrolase 9 484 1.3E-149 T 17-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 SUPERFAMILY SSF51735 243 405 2.63E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 Gene3D G3DSA:3.40.50.1480 406 485 2.1E-149 T 17-03-2017 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 Gene3D G3DSA:3.40.50.1480 8 244 2.1E-149 T 17-03-2017 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 TIGRFAM TIGR00936 ahcY: adenosylhomocysteinase 10 477 1.3E-192 T 17-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 Hamap MF_00563 Adenosylhomocysteinase [ahcY]. 5 477 49.841 T 17-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 SMART SM00996 9 484 0.0 T 17-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 SMART SM00997 243 405 4.9E-111 T 17-03-2017 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 ProSitePatterns PS00738 S-adenosyl-L-homocysteine hydrolase signature 1. 81 95 - T 17-03-2017 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 Gene3D G3DSA:3.40.50.720 245 404 1.3E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 PIRSF PIRSF001109 1 485 4.1E-194 T 17-03-2017 IPR000043 Adenosylhomocysteinase GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 ProSitePatterns PS00739 S-adenosyl-L-homocysteine hydrolase signature 2. 265 281 - T 17-03-2017 IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved site GO:0004013|GO:0006730 KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS24155 95169217a96155127f1610a4d2436b20 485 Pfam PF00670 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 243 405 9.1E-84 T 17-03-2017 IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domain KEGG: 00270+3.3.1.1|MetaCyc: PWY-5041 SHXM_RS46175 57feac90acf0d194f1eefb6f82bf47ce 327 Pfam PF00248 Aldo/keto reductase family 16 309 1.4E-59 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS46175 57feac90acf0d194f1eefb6f82bf47ce 327 Gene3D G3DSA:3.20.20.100 1 315 9.6E-75 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS46175 57feac90acf0d194f1eefb6f82bf47ce 327 SUPERFAMILY SSF51430 1 317 6.81E-77 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS25700 7593e8aa01f3dfc61165a9c0f0a7d078 1173 Gene3D G3DSA:3.30.565.10 28 237 1.2E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25700 7593e8aa01f3dfc61165a9c0f0a7d078 1173 SUPERFAMILY SSF55874 48 144 2.51E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 SUPERFAMILY SSF51735 11 254 1.15E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 Gene3D G3DSA:3.40.50.720 10 254 1.2E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 254 1.1E-45 T 17-03-2017 SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 3.1E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 3.1E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 3.1E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 218 238 3.1E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47155 fa6c7b7acbfaa999a3f445e834182ddf 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 3.1E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF55048 699 764 2.22E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 33 282 6.7E-85 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF00698 Acyl transferase domain 574 891 1.9E-93 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.50.720 1847 2030 6.9E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.50.720 1435 1616 2.6E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF53474 2343 2578 6.38E-36 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF53474 2228 2266 6.38E-36 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF00550 Phosphopantetheine attachment site 2201 2265 4.6E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF51735 1624 1834 9.45E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 410 538 9.7E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1848 2027 9.5E-51 T 17-03-2017 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1434 1614 4.5E-52 T 17-03-2017 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF14765 Polyketide synthase dehydratase 940 1225 2.4E-47 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00826 940 1107 7.2E-76 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM01294 2199 2266 0.0026 T 17-03-2017 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF52151 571 700 1.15E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF52151 765 863 1.15E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:1.10.1200.10 2195 2271 1.5E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF00975 Thioesterase domain 2367 2576 2.0E-14 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF51735 1231 1418 2.76E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF51735 1844 2077 4.47E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.366.10 561 695 3.6E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.366.10 764 886 3.6E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.47.10 35 294 4.0E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.47.10 295 461 4.3E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00825 Beta-ketoacyl synthase 35 460 1.2E-216 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.40.50.1820 2311 2579 1.1E-73 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF08990 Erythronolide synthase docking 3 26 2.0E-9 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00823 Phosphopantetheine attachment site 2198 2270 4.2E-24 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF51735 1433 1626 2.21E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF08659 KR domain 1434 1613 4.3E-52 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF08659 KR domain 1848 2026 2.3E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 195 211 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00824 Thioesterase 2368 2578 2.2E-90 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Gene3D G3DSA:3.30.70.250 699 763 4.7E-10 T 17-03-2017 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SUPERFAMILY SSF53901 30 405 1.38E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 290 407 2.8E-46 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45380 a081f9c99bd1ad739e0106d09d265c49 2581 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 575 873 2.7E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 SUPERFAMILY SSF47384 225 305 1.37E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 353 465 7.3E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 SMART SM00304 188 241 2.1E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 Gene3D G3DSA:3.30.450.20 42 158 1.5E-5 T 17-03-2017 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 Pfam PF00512 His Kinase A (phospho-acceptor) domain 242 305 2.2E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 Gene3D G3DSA:1.10.287.130 233 302 6.7E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 SUPERFAMILY SSF158472 188 239 4.58E-7 T 17-03-2017 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 PRINTS PR00344 Bacterial sensor protein C-terminal signature 396 410 1.7E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 PRINTS PR00344 Bacterial sensor protein C-terminal signature 428 446 1.7E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 PRINTS PR00344 Bacterial sensor protein C-terminal signature 414 424 1.7E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 SMART SM00387 349 470 3.3E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 Pfam PF00672 HAMP domain 169 238 2.9E-13 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 Gene3D G3DSA:3.30.565.10 307 467 4.6E-31 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 SUPERFAMILY SSF55874 297 464 2.75E-30 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08700 494e6163ff90715ea50ed0b49fab06bc 502 SMART SM00388 242 306 2.1E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS31170 82c0ccb84100c2b6cfb1d689a3ba2bfe 217 TIGRFAM TIGR03953 rplD_bact: 50S ribosomal protein uL4 17 202 1.6E-69 T 17-03-2017 IPR013005 50S ribosomal protein uL4 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31170 82c0ccb84100c2b6cfb1d689a3ba2bfe 217 Pfam PF00573 Ribosomal protein L4/L1 family 17 202 3.1E-63 T 17-03-2017 IPR002136 Ribosomal protein L4/L1e GO:0003735|GO:0005840|GO:0006412 SHXM_RS31170 82c0ccb84100c2b6cfb1d689a3ba2bfe 217 Hamap MF_01328_B 50S ribosomal protein L4 [rplD]. 9 207 32.68 T 17-03-2017 IPR013005 50S ribosomal protein uL4 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31170 82c0ccb84100c2b6cfb1d689a3ba2bfe 217 Gene3D G3DSA:3.40.1370.10 58 202 1.8E-49 T 17-03-2017 IPR023574 Ribosomal protein L4 domain GO:0003735|GO:0005840|GO:0006412 SHXM_RS31170 82c0ccb84100c2b6cfb1d689a3ba2bfe 217 SUPERFAMILY SSF52166 1 203 1.13E-73 T 17-03-2017 IPR023574 Ribosomal protein L4 domain GO:0003735|GO:0005840|GO:0006412 SHXM_RS05885 bf97ec974f9202a281f8dfa011ed0402 169 Pfam PF04978 Protein of unknown function (DUF664) 18 165 7.7E-44 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS05885 bf97ec974f9202a281f8dfa011ed0402 169 SUPERFAMILY SSF109854 3 164 7.94E-41 T 17-03-2017 SHXM_RS05885 bf97ec974f9202a281f8dfa011ed0402 169 Gene3D G3DSA:1.20.120.450 2 168 2.7E-46 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS38560 920910ede9e4ec96edceef271c97549d 193 SUPERFAMILY SSF109854 6 137 2.14E-22 T 17-03-2017 SHXM_RS38560 920910ede9e4ec96edceef271c97549d 193 TIGRFAM TIGR03086 TIGR03086: TIGR03086 family protein 6 187 8.0E-50 T 17-03-2017 IPR017520 Conserved hypothetical protein CHP03086 SHXM_RS38560 920910ede9e4ec96edceef271c97549d 193 Gene3D G3DSA:1.20.120.450 6 95 4.5E-5 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS38560 920910ede9e4ec96edceef271c97549d 193 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 7 187 1.6E-24 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS38560 920910ede9e4ec96edceef271c97549d 193 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 8 131 6.7E-15 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 SUPERFAMILY SSF50249 130 186 1.71E-17 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Gene3D G3DSA:2.40.50.140 65 128 3.9E-24 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Pfam PF01132 Elongation factor P (EF-P) OB domain 69 122 5.9E-21 T 17-03-2017 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 ProSitePatterns PS01275 Elongation factor P signature. 151 170 - T 17-03-2017 IPR013852 Translation elongation factor P/YeiP, conserved site SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Pfam PF09285 Elongation factor P, C-terminal 130 185 4.0E-25 T 17-03-2017 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 PIRSF PIRSF005901 1 187 6.2E-66 T 17-03-2017 IPR020599 Translation elongation factor P/YeiP SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Gene3D G3DSA:2.30.30.30 3 64 3.1E-30 T 17-03-2017 IPR014722 Ribosomal protein L2 domain 2 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 SMART SM00841 130 185 4.8E-31 T 17-03-2017 IPR015365 Elongation factor P, C-terminal GO:0005737|GO:0043043 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 SUPERFAMILY SSF50104 2 64 4.51E-18 T 17-03-2017 IPR008991 Translation protein SH3-like domain SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 SMART SM01185 68 122 1.6E-25 T 17-03-2017 IPR001059 Translation elongation factor P/YeiP, central GO:0003746|GO:0006414 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Pfam PF08207 Elongation factor P (EF-P) KOW-like domain 3 61 2.5E-25 T 17-03-2017 IPR013185 Translation elongation factor, KOW-like SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Gene3D G3DSA:2.40.50.140 130 186 2.7E-27 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 TIGRFAM TIGR00038 efp: translation elongation factor P 3 186 3.5E-74 T 17-03-2017 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 Hamap MF_00141 Elongation factor P [efp]. 1 186 49.463 T 17-03-2017 IPR011768 Translation elongation factor P GO:0003746|GO:0005737|GO:0006414 SHXM_RS12395 ba789aad8f49f633c001a7940c57369a 188 SUPERFAMILY SSF50249 66 127 2.53E-18 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS03755 04e273402680dd69f9d89edfe29d805c 342 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 89 103 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS03755 04e273402680dd69f9d89edfe29d805c 342 SUPERFAMILY SSF48576 11 341 1.08E-79 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS03755 04e273402680dd69f9d89edfe29d805c 342 Pfam PF00348 Polyprenyl synthetase 38 278 1.0E-51 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS03755 04e273402680dd69f9d89edfe29d805c 342 Gene3D G3DSA:1.10.600.10 13 341 4.8E-85 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 TIGRFAM TIGR00179 murB: UDP-N-acetylenolpyruvoylglucosamine reductase 9 343 4.7E-46 T 17-03-2017 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Pfam PF01565 FAD binding domain 24 138 5.2E-20 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 SUPERFAMILY SSF56176 8 183 5.14E-35 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Gene3D G3DSA:3.30.43.10 8 72 5.1E-23 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Gene3D G3DSA:3.30.465.10 76 188 1.0E-46 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Gene3D G3DSA:3.30.465.10 223 239 1.0E-46 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Pfam PF02873 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain 213 347 1.9E-36 T 17-03-2017 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Hamap MF_00037 UDP-N-acetylenolpyruvoylglucosamine reductase [murB]. 1 351 74.841 T 17-03-2017 IPR003170 UDP-N-acetylenolpyruvoylglucosamine reductase GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 SUPERFAMILY SSF56194 213 349 5.49E-32 T 17-03-2017 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS31055 f2c7c1179e5930ceb2877ba0029f0d90 351 Gene3D G3DSA:3.90.78.10 240 350 5.3E-43 T 17-03-2017 IPR011601 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal GO:0008762|GO:0055114 KEGG: 00520+1.3.1.98|KEGG: 00550+1.3.1.98|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS43455 5fde3e61a43901ccefbb57b5e1d54220 280 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 17 162 1.0E-21 T 17-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS43455 5fde3e61a43901ccefbb57b5e1d54220 280 SUPERFAMILY SSF56770 6 228 8.11E-41 T 17-03-2017 SHXM_RS43455 5fde3e61a43901ccefbb57b5e1d54220 280 Gene3D G3DSA:3.40.50.700 6 177 1.9E-23 T 17-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 TIGRFAM TIGR01017 rpsD_bact: ribosomal protein uS4 5 203 5.5E-60 T 17-03-2017 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 SUPERFAMILY SSF55174 5 203 3.01E-54 T 17-03-2017 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 Pfam PF00163 Ribosomal protein S4/S9 N-terminal domain 5 90 1.4E-17 T 17-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 SMART SM01390 2 90 7.0E-32 T 17-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 Pfam PF01479 S4 domain 91 138 1.0E-17 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 Hamap MF_01306_B 30S ribosomal protein S4 [rpsD]. 1 203 28.9 T 17-03-2017 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 ProSitePatterns PS00632 Ribosomal protein S4 signature. 89 113 - T 17-03-2017 IPR018079 Ribosomal protein S4, conserved site GO:0005622|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6790901|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 Gene3D G3DSA:3.10.290.10 97 185 1.2E-23 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 Gene3D G3DSA:1.10.1050.10 4 96 1.3E-26 T 17-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 SHXM_RS12455 bd182c515e48593ea984312a188d0b08 203 SMART SM00363 91 157 1.2E-14 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:1.10.1200.10 987 1050 6.1E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:1.10.1200.10 2510 2571 1.2E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 2762 3030 2.33E-33 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 2897 3053 1.6E-44 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 TIGRFAM TIGR01720 NRPS-para261: non-ribosomal peptide synthase domain TIGR01720 1375 1528 4.4E-42 T 17-03-2017 IPR010060 Non-ribosomal peptide synthase SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 1718 1981 1.33E-58 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 ProSitePatterns PS00455 Putative AMP-binding domain signature. 2143 2154 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 2581 2773 2.89E-29 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:2.30.38.10 2310 2389 5.6E-26 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:2.30.38.10 789 867 2.8E-29 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:3.40.50.980 2153 2309 4.4E-47 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:3.40.50.980 633 788 1.1E-30 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:3.40.50.980 470 632 1.3E-53 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:3.40.50.980 1986 2152 2.0E-51 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00501 AMP-binding enzyme 1994 2399 1.8E-100 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00501 AMP-binding enzyme 477 877 5.7E-97 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF47336 977 1045 1.31E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 11 185 5.78E-37 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 ProSitePatterns PS00455 Putative AMP-binding domain signature. 624 635 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 498 901 3.3E-133 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 2014 2423 2.0E-139 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 1240 1504 4.0E-31 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2529 2544 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1007 1022 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:3.30.300.30 872 986 1.8E-41 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Gene3D G3DSA:3.30.300.30 2394 2509 7.4E-42 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 1534 1733 8.89E-42 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SMART SM00823 Phosphopantetheine attachment site 2505 2573 1.9E-8 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SMART SM00823 Phosphopantetheine attachment site 983 1051 4.8E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00550 Phosphopantetheine attachment site 2506 2568 5.8E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00550 Phosphopantetheine attachment site 984 1046 6.1E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 1058 1251 9.78E-29 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF52777 191 465 9.12E-38 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF13193 AMP-binding enzyme C-terminal domain 2407 2480 2.1E-15 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF13193 AMP-binding enzyme C-terminal domain 885 958 3.3E-14 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF47336 2499 2567 1.06E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF56801 437 996 3.4E-156 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 SUPERFAMILY SSF56801 1955 2518 4.71E-168 T 17-03-2017 SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00668 Condensation domain 2587 2882 2.8E-36 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00668 Condensation domain 9 301 5.8E-55 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00668 Condensation domain 1083 1360 2.9E-32 T 17-03-2017 IPR001242 Condensation domain SHXM_RS02200 d492b2f44dfdac039585fbf55a945ef3 3068 Pfam PF00668 Condensation domain 1536 1832 8.6E-64 T 17-03-2017 IPR001242 Condensation domain SHXM_RS31155 386e722726059927de2ef167d02b51b5 709 SUPERFAMILY SSF89372 367 597 1.7E-15 T 17-03-2017 SHXM_RS31155 386e722726059927de2ef167d02b51b5 709 Gene3D G3DSA:3.40.50.10320 67 168 5.6E-23 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS31155 386e722726059927de2ef167d02b51b5 709 Gene3D G3DSA:3.40.50.10320 212 306 5.6E-23 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS31155 386e722726059927de2ef167d02b51b5 709 Pfam PF02585 GlcNAc-PI de-N-acetylase 68 280 2.6E-22 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS31155 386e722726059927de2ef167d02b51b5 709 SUPERFAMILY SSF102588 67 139 3.66E-18 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS31155 386e722726059927de2ef167d02b51b5 709 SUPERFAMILY SSF102588 169 291 3.66E-18 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS19345 3af4c231d6f30064d03691d9bdc5e1b4 208 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 11 98 9.1E-13 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS19345 3af4c231d6f30064d03691d9bdc5e1b4 208 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 10 190 9.6E-24 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS19345 3af4c231d6f30064d03691d9bdc5e1b4 208 SUPERFAMILY SSF109854 2 129 3.66E-16 T 17-03-2017 SHXM_RS19345 3af4c231d6f30064d03691d9bdc5e1b4 208 Gene3D G3DSA:1.20.120.450 3 94 1.3E-9 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS15890 87d1de1b5fed0e9068cbdf7aaa79baf8 331 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 93 183 9.7E-20 T 17-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SHXM_RS15890 87d1de1b5fed0e9068cbdf7aaa79baf8 331 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 241 328 6.3E-20 T 17-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SHXM_RS15890 87d1de1b5fed0e9068cbdf7aaa79baf8 331 Gene3D G3DSA:3.10.50.40 59 184 8.8E-30 T 17-03-2017 SHXM_RS15890 87d1de1b5fed0e9068cbdf7aaa79baf8 331 SUPERFAMILY SSF54534 56 189 2.36E-28 T 17-03-2017 SHXM_RS15890 87d1de1b5fed0e9068cbdf7aaa79baf8 331 SUPERFAMILY SSF54534 220 330 1.04E-32 T 17-03-2017 SHXM_RS15890 87d1de1b5fed0e9068cbdf7aaa79baf8 331 Gene3D G3DSA:3.10.50.40 219 330 4.0E-32 T 17-03-2017 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 SMART SM00354 4 74 4.2E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 SUPERFAMILY SSF47413 4 62 2.55E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 Gene3D G3DSA:3.40.50.2300 57 175 5.2E-46 T 17-03-2017 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 ProSitePatterns PS00356 LacI-type HTH domain signature. 7 25 - T 17-03-2017 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 Pfam PF13377 Periplasmic binding protein-like domain 171 330 1.1E-36 T 17-03-2017 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 Gene3D G3DSA:1.10.260.40 5 56 2.4E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 SUPERFAMILY SSF53822 65 334 7.92E-72 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 Gene3D G3DSA:3.40.50.2300 176 313 1.1E-46 T 17-03-2017 SHXM_RS10815 bd587ede9ab0066ad31cb95d69c85d50 344 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 51 1.7E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS21915 bdd46dd38edf22a84fd45f21c977cf9b 442 Pfam PF01547 Bacterial extracellular solute-binding protein 49 350 7.7E-34 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS21915 bdd46dd38edf22a84fd45f21c977cf9b 442 Gene3D G3DSA:3.40.190.10 39 155 6.1E-39 T 17-03-2017 SHXM_RS21915 bdd46dd38edf22a84fd45f21c977cf9b 442 Gene3D G3DSA:3.40.190.10 334 388 6.1E-39 T 17-03-2017 SHXM_RS21915 bdd46dd38edf22a84fd45f21c977cf9b 442 Gene3D G3DSA:3.40.190.10 156 333 3.7E-30 T 17-03-2017 SHXM_RS21915 bdd46dd38edf22a84fd45f21c977cf9b 442 SUPERFAMILY SSF53850 20 436 4.4E-63 T 17-03-2017 SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 SUPERFAMILY SSF52540 23 226 1.38E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 SMART SM00382 35 221 1.3E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 SMART SM00382 368 550 9.2E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 SUPERFAMILY SSF52540 326 523 5.07E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 Gene3D G3DSA:3.40.50.300 13 263 1.1E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 Pfam PF00005 ABC transporter 360 489 6.9E-19 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 Pfam PF00005 ABC transporter 29 176 7.6E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS04295 db46601ed7ddf3d096dbf3d257d402f7 557 Gene3D G3DSA:3.40.50.300 345 523 3.0E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16700 11c244ee2d894d491f7a8c6308b1b765 239 SUPERFAMILY SSF53901 1 239 3.69E-74 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16700 11c244ee2d894d491f7a8c6308b1b765 239 SMART SM00825 Beta-ketoacyl synthase 1 237 1.1E-33 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS16700 11c244ee2d894d491f7a8c6308b1b765 239 Gene3D G3DSA:3.40.47.10 1 239 6.4E-81 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16700 11c244ee2d894d491f7a8c6308b1b765 239 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 153 169 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS16700 11c244ee2d894d491f7a8c6308b1b765 239 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 239 9.0E-83 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS40985 40d157d58896d9649dc492c9045c454d 432 Pfam PF01547 Bacterial extracellular solute-binding protein 78 343 4.8E-30 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS40985 40d157d58896d9649dc492c9045c454d 432 Gene3D G3DSA:3.40.190.10 174 347 7.7E-31 T 17-03-2017 SHXM_RS40985 40d157d58896d9649dc492c9045c454d 432 SUPERFAMILY SSF53850 80 362 5.43E-47 T 17-03-2017 SHXM_RS40985 40d157d58896d9649dc492c9045c454d 432 Gene3D G3DSA:3.40.190.10 87 173 7.9E-10 T 17-03-2017 SHXM_RS14955 50c1357433be5daf04e3f64a4022367b 291 ProSitePatterns PS00211 ABC transporters family signature. 130 144 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS14955 50c1357433be5daf04e3f64a4022367b 291 Pfam PF00005 ABC transporter 21 157 5.0E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS14955 50c1357433be5daf04e3f64a4022367b 291 SMART SM00382 29 206 5.5E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14955 50c1357433be5daf04e3f64a4022367b 291 SUPERFAMILY SSF52540 3 228 2.11E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14955 50c1357433be5daf04e3f64a4022367b 291 Gene3D G3DSA:3.40.50.300 2 219 1.2E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 5 498 1.1E-206 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 Gene3D G3DSA:3.30.420.40 3 254 2.6E-99 T 17-03-2017 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 SUPERFAMILY SSF53067 5 256 8.68E-86 T 17-03-2017 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 5 253 8.3E-72 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 SUPERFAMILY SSF53067 256 499 2.37E-77 T 17-03-2017 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 364 384 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 262 451 2.0E-61 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 Gene3D G3DSA:3.30.420.40 256 499 7.0E-95 T 17-03-2017 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 Hamap MF_00186 Glycerol kinase [glpK]. 3 499 52.076 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS03990 2ff715ac946ecce80eddd0e71ef21c19 501 PIRSF PIRSF000538 3 501 1.1E-157 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 SUPERFAMILY SSF56300 117 203 1.64E-38 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 SUPERFAMILY SSF56300 381 520 1.64E-38 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 SUPERFAMILY SSF56300 262 289 1.64E-38 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 14 45 3.0E-4 T 17-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 TIGRFAM TIGR03767 P_acnes_RR: metallophosphoesterase, PPA1498 family 82 577 8.5E-216 T 17-03-2017 IPR022506 Metallophosphoesterase, PPA1498 SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 Pfam PF00149 Calcineurin-like phosphoesterase 118 481 8.1E-8 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 Gene3D G3DSA:3.60.21.10 347 520 3.9E-73 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 Gene3D G3DSA:3.60.21.10 116 203 3.9E-73 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS21845 7aa82fc78db9d1df5b258496d52c41e6 577 Gene3D G3DSA:3.60.21.10 262 277 3.9E-73 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS29945 fbd5c339102d1bdc853735c81eb9613e 258 TIGRFAM TIGR00972 3a0107s01c2: phosphate ABC transporter, ATP-binding protein 5 258 9.8E-113 T 17-03-2017 IPR005670 Phosphate transport system permease protein 1 GO:0005315|GO:0016020|GO:0035435 SHXM_RS29945 fbd5c339102d1bdc853735c81eb9613e 258 SUPERFAMILY SSF52540 5 246 7.1E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29945 fbd5c339102d1bdc853735c81eb9613e 258 Pfam PF00005 ABC transporter 21 176 5.8E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS29945 fbd5c339102d1bdc853735c81eb9613e 258 SMART SM00382 29 229 4.7E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS29945 fbd5c339102d1bdc853735c81eb9613e 258 ProSitePatterns PS00211 ABC transporters family signature. 149 163 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS29945 fbd5c339102d1bdc853735c81eb9613e 258 Gene3D G3DSA:3.40.50.300 4 251 4.3E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47200 6a8764199ff5f4e630dee6cea6294209 394 SUPERFAMILY SSF81296 73 145 1.04E-7 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS47200 6a8764199ff5f4e630dee6cea6294209 394 Gene3D G3DSA:2.60.40.10 72 141 1.0E-8 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS47200 6a8764199ff5f4e630dee6cea6294209 394 Gene3D G3DSA:2.60.40.10 238 276 1.3E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS47200 6a8764199ff5f4e630dee6cea6294209 394 Pfam PF01833 IPT/TIG domain 74 143 8.3E-6 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47200 6a8764199ff5f4e630dee6cea6294209 394 SUPERFAMILY SSF81296 238 284 1.11E-5 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS44910 ee7b969b4a3aaec3bc627841b7c4235f 419 Pfam PF00202 Aminotransferase class-III 12 411 6.8E-119 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS44910 ee7b969b4a3aaec3bc627841b7c4235f 419 SUPERFAMILY SSF53383 10 412 7.98E-133 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS44910 ee7b969b4a3aaec3bc627841b7c4235f 419 Gene3D G3DSA:3.90.1150.10 299 413 1.6E-42 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS44910 ee7b969b4a3aaec3bc627841b7c4235f 419 Gene3D G3DSA:3.40.640.10 48 298 5.9E-88 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS44910 ee7b969b4a3aaec3bc627841b7c4235f 419 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 229 266 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS02475 cbd1fedcf210d1af240a6c122614d671 192 Pfam PF01966 HD domain 36 107 5.7E-8 T 17-03-2017 IPR006674 HD domain SHXM_RS02475 cbd1fedcf210d1af240a6c122614d671 192 SUPERFAMILY SSF109604 37 107 2.02E-7 T 17-03-2017 SHXM_RS02475 cbd1fedcf210d1af240a6c122614d671 192 TIGRFAM TIGR00277 HDIG: HDIG domain 40 107 2.7E-7 T 17-03-2017 IPR006675 HDIG domain SHXM_RS02475 cbd1fedcf210d1af240a6c122614d671 192 Gene3D G3DSA:1.10.3210.10 44 106 2.2E-5 T 17-03-2017 IPR006674 HD domain SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 Gene3D G3DSA:2.60.220.10 745 858 6.0E-28 T 17-03-2017 IPR004103 Polysaccharide lyase family 8, C-terminal GO:0005576|GO:0016829 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 Pfam PF02278 Polysaccharide lyase family 8, super-sandwich domain 432 732 2.0E-63 T 17-03-2017 IPR003159 Polysaccharide lyase family 8, central domain GO:0005576|GO:0016829 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 Pfam PF08124 Polysaccharide lyase family 8, N terminal alpha-helical domain 61 383 4.3E-54 T 17-03-2017 IPR012970 Polysaccharide lyase 8, N-terminal alpha-helical SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 SUPERFAMILY SSF48230 67 392 2.59E-56 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 SUPERFAMILY SSF48230 430 451 2.59E-56 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 Gene3D G3DSA:1.50.10.100 50 442 1.1E-82 T 17-03-2017 IPR012329 Polysaccharide lyase family 8, N-terminal GO:0005975|GO:0016837 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 Pfam PF02884 Polysaccharide lyase family 8, C-terminal beta-sandwich domain 747 812 2.5E-17 T 17-03-2017 IPR004103 Polysaccharide lyase family 8, C-terminal GO:0005576|GO:0016829 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 SUPERFAMILY SSF74650 430 742 2.04E-39 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 SUPERFAMILY SSF49863 745 857 2.94E-20 T 17-03-2017 IPR011071 Polysaccharide lyase family 8-like, C-terminal GO:0005975 SHXM_RS04650 7f6cae98da493faaf0d05e89389de416 858 Gene3D G3DSA:2.70.98.10 443 734 8.0E-62 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 SUPERFAMILY SSF51735 223 264 6.28E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 SUPERFAMILY SSF51735 299 469 6.28E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 SUPERFAMILY SSF51735 18 204 3.24E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 223 452 1.9E-17 T 17-03-2017 SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 Gene3D G3DSA:3.40.50.720 224 256 8.0E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 Gene3D G3DSA:3.40.50.720 300 469 8.0E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13370 175d83297833553d577c6fc343d7ae4c 793 Pfam PF08659 KR domain 224 447 5.7E-27 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS00500 ad5fccde971b877ef24baa680ad9a820 381 Gene3D G3DSA:3.30.420.10 225 351 1.2E-7 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00500 ad5fccde971b877ef24baa680ad9a820 381 SUPERFAMILY SSF53098 227 351 8.09E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00500 ad5fccde971b877ef24baa680ad9a820 381 Pfam PF13551 Winged helix-turn helix 43 102 1.1E-12 T 17-03-2017 SHXM_RS00500 ad5fccde971b877ef24baa680ad9a820 381 Pfam PF13358 DDE superfamily endonuclease 189 327 3.2E-16 T 17-03-2017 SHXM_RS00500 ad5fccde971b877ef24baa680ad9a820 381 SUPERFAMILY SSF46689 26 144 1.67E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 Gene3D G3DSA:1.10.10.10 163 256 4.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 SUPERFAMILY SSF52172 17 144 9.25E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 Pfam PF00072 Response regulator receiver domain 23 131 6.3E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 SUPERFAMILY SSF46894 161 255 2.55E-25 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 Pfam PF00486 Transcriptional regulatory protein, C terminal 184 255 1.1E-19 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 SMART SM00448 20 130 2.2E-41 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 Gene3D G3DSA:3.40.50.2300 20 141 5.5E-40 T 17-03-2017 SHXM_RS07005 f0c27c55d9849f88e187acee3c8aef49 257 SMART SM00862 184 255 4.3E-20 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS45235 cfe2dbddc6fdcbb366668d5d30c9baa1 172 Pfam PF06841 T4-like virus tail tube protein gp19 34 154 7.2E-31 T 17-03-2017 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 SHXM_RS45235 cfe2dbddc6fdcbb366668d5d30c9baa1 172 TIGRFAM TIGR02241 TIGR02241: conserved hypothetical phage tail region protein 4 154 2.3E-29 T 17-03-2017 IPR011747 Conserved hypothetical protein CHP02241 SHXM_RS42775 d97dae60385a22b520358e48f401a128 493 Pfam PF08309 LVIVD repeat 90 127 6.3E-4 T 17-03-2017 IPR013211 LVIVD SHXM_RS42775 d97dae60385a22b520358e48f401a128 493 SUPERFAMILY SSF75011 173 462 8.89E-7 T 17-03-2017 SHXM_RS03135 d767100ccf6aeaadd7ed36842114b045 230 SUPERFAMILY SSF53098 4 146 3.67E-38 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS03135 d767100ccf6aeaadd7ed36842114b045 230 Gene3D G3DSA:3.30.420.10 2 149 4.6E-43 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS03135 d767100ccf6aeaadd7ed36842114b045 230 Hamap MF_00042 Ribonuclease H [rnhA]. 2 154 31.965 T 17-03-2017 IPR022892 Ribonuclease H GO:0004523 SHXM_RS03135 d767100ccf6aeaadd7ed36842114b045 230 Pfam PF00075 RNase H 4 145 1.4E-27 T 17-03-2017 IPR002156 Ribonuclease H domain GO:0003676|GO:0004523 SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 Gene3D G3DSA:3.30.450.40 202 360 1.2E-18 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 SUPERFAMILY SSF55781 34 217 6.98E-39 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 Gene3D G3DSA:3.30.450.40 25 201 1.0E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 SUPERFAMILY SSF55874 478 568 3.41E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 Pfam PF13185 GAF domain 220 357 1.0E-9 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 Pfam PF13185 GAF domain 51 190 7.2E-17 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 SMART SM00387 479 570 3.7E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 SMART SM00065 220 366 0.0038 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 SMART SM00065 52 199 7.1E-21 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 SUPERFAMILY SSF55781 201 382 2.84E-21 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 Gene3D G3DSA:3.30.565.10 449 569 5.3E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50125 e6982ce42cce6e7a99841618507b1b53 572 Pfam PF07730 Histidine kinase 374 435 3.3E-10 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS35640 7978e57694ce7c52975d5a2bf40c81f2 305 Gene3D G3DSA:1.20.58.370 26 57 9.1E-5 T 17-03-2017 SHXM_RS35640 7978e57694ce7c52975d5a2bf40c81f2 305 Gene3D G3DSA:1.10.3720.10 76 304 7.0E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35640 7978e57694ce7c52975d5a2bf40c81f2 305 SUPERFAMILY SSF160964 24 58 8.24E-6 T 17-03-2017 SHXM_RS35640 7978e57694ce7c52975d5a2bf40c81f2 305 SUPERFAMILY SSF161098 70 295 2.88E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35640 7978e57694ce7c52975d5a2bf40c81f2 305 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 297 3.0E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 Pfam PF03466 LysR substrate binding domain 102 293 2.7E-16 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 3.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 3.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 3.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 Gene3D G3DSA:3.40.190.10 97 193 7.3E-10 T 17-03-2017 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 SUPERFAMILY SSF53850 101 295 2.31E-21 T 17-03-2017 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 SUPERFAMILY SSF46785 2 83 1.39E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 4.6E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05400 24d3bd0ebee4fad76683afa0f2849037 309 Gene3D G3DSA:1.10.10.10 2 83 2.2E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37900 df4d4095455ad22b93bae5a96b64ab27 255 Gene3D G3DSA:3.40.50.10320 3 250 1.8E-28 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS37900 df4d4095455ad22b93bae5a96b64ab27 255 SUPERFAMILY SSF102588 2 230 2.35E-34 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS37900 df4d4095455ad22b93bae5a96b64ab27 255 Pfam PF02585 GlcNAc-PI de-N-acetylase 6 162 4.8E-17 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS43065 d6bfa4d58238ed8de3868671ae014e11 229 SUPERFAMILY SSF48317 6 215 1.44E-32 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS43065 d6bfa4d58238ed8de3868671ae014e11 229 Pfam PF01569 PAP2 superfamily 93 211 3.6E-23 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS43065 d6bfa4d58238ed8de3868671ae014e11 229 Gene3D G3DSA:1.20.144.10 22 219 1.7E-30 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS43065 d6bfa4d58238ed8de3868671ae014e11 229 SMART SM00014 92 206 5.5E-14 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 SUPERFAMILY SSF47336 553 626 1.83E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:3.40.50.980 8 164 3.6E-24 T 17-03-2017 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Pfam PF00975 Thioesterase domain 652 898 1.9E-30 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 SUPERFAMILY SSF56801 8 536 1.05E-102 T 17-03-2017 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 SMART SM00824 Thioesterase 654 907 5.1E-5 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:3.40.50.980 165 326 9.6E-32 T 17-03-2017 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Pfam PF00501 AMP-binding enzyme 22 426 2.9E-70 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:3.40.50.1820 636 755 1.0E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:3.40.50.1820 837 908 1.0E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 SMART SM00823 Phosphopantetheine attachment site 557 630 0.0071 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:3.30.300.30 420 527 4.5E-11 T 17-03-2017 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:2.30.38.10 340 419 5.9E-23 T 17-03-2017 SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 SUPERFAMILY SSF53474 636 907 3.75E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 ProSitePatterns PS00455 Putative AMP-binding domain signature. 156 167 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Gene3D G3DSA:1.10.1200.10 552 630 4.7E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02595 58ddc354e88f67982745461cf9a26e42 912 Pfam PF00550 Phosphopantetheine attachment site 562 625 5.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 SUPERFAMILY SSF50965 60 137 6.02E-37 T 17-03-2017 IPR011043 Galactose oxidase/kelch, beta-propeller SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 SUPERFAMILY SSF50965 258 544 6.02E-37 T 17-03-2017 IPR011043 Galactose oxidase/kelch, beta-propeller SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 Pfam PF09118 Domain of unknown function (DUF1929) 548 643 1.0E-21 T 17-03-2017 IPR015202 Domain of unknown function DUF1929 SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 Gene3D G3DSA:2.130.10.80 257 548 4.4E-66 T 17-03-2017 IPR015916 Galactose oxidase, beta-propeller SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 Gene3D G3DSA:2.130.10.80 59 136 4.4E-66 T 17-03-2017 IPR015916 Galactose oxidase, beta-propeller SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 SUPERFAMILY SSF81296 544 643 1.26E-21 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS23250 6d5eb1fb76be226096304b5204330445 649 Gene3D G3DSA:2.60.40.10 549 643 4.4E-27 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 ProSitePatterns PS00622 LuxR-type HTH domain signature. 238 265 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 Pfam PF00072 Response regulator receiver domain 70 187 6.9E-16 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 Pfam PF00196 Bacterial regulatory proteins, luxR family 223 278 1.3E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 SUPERFAMILY SSF52172 67 205 7.4E-22 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 SMART SM00421 221 278 6.0E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 224 238 1.6E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 254 266 1.6E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 238 254 1.6E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 SMART SM00448 68 187 1.7E-15 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 Gene3D G3DSA:1.10.10.10 191 284 3.6E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 SUPERFAMILY SSF46894 214 283 2.96E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS25375 d7718db7db604b9f56d8b65354d86815 284 Gene3D G3DSA:3.40.50.2300 65 190 2.3E-24 T 17-03-2017 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 Gene3D G3DSA:3.40.50.720 3 123 1.4E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 Gene3D G3DSA:3.40.50.261 124 286 1.9E-65 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 Pfam PF02629 CoA binding domain 6 103 3.6E-24 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 SUPERFAMILY SSF52210 127 289 2.49E-46 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 ProSitePatterns PS01216 ATP-citrate lyase / succinyl-CoA ligases family signature 1. 156 183 - T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 Pfam PF00549 CoA-ligase 156 273 6.4E-13 T 17-03-2017 IPR005811 ATP-citrate lyase/succinyl-CoA ligase GO:0003824|GO:0008152 KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 SUPERFAMILY SSF51735 1 126 4.12E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 PIRSF PIRSF001553 1 293 3.9E-112 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 TIGRFAM TIGR01019 sucCoAalpha: succinate-CoA ligase, alpha subunit 3 290 1.1E-122 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 SMART SM00881 4 104 2.5E-27 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 PRINTS PR01798 Succinyl-CoA synthase signature 179 197 3.6E-32 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 PRINTS PR01798 Succinyl-CoA synthase signature 242 259 3.6E-32 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 PRINTS PR01798 Succinyl-CoA synthase signature 86 103 3.6E-32 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 PRINTS PR01798 Succinyl-CoA synthase signature 210 223 3.6E-32 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS14110 61432929a39386031eb4c5f9feb92894 298 ProSitePatterns PS00399 ATP-citrate lyase / succinyl-CoA ligases family active site. 238 251 - T 17-03-2017 IPR017440 ATP-citrate lyase/succinyl-CoA ligase, active site SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 Gene3D G3DSA:1.10.45.10 418 457 6.6E-13 T 17-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 Pfam PF02913 FAD linked oxidases, C-terminal domain 217 456 1.4E-48 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 SUPERFAMILY SSF56176 17 217 7.01E-68 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 Gene3D G3DSA:3.30.465.10 97 217 4.8E-43 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 Pfam PF01565 FAD binding domain 42 179 9.2E-42 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 SUPERFAMILY SSF55103 220 457 8.5E-49 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS01960 c0d6ef08dbc76d8167c5815be6df03de 458 Gene3D G3DSA:3.30.43.10 19 96 9.1E-21 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS14345 cd6e3578ebd2646d8d8dbcb64aa2847e 103 Hamap MF_00434 Putative pterin-4-alpha-carbinolamine dehydratase. 3 95 21.153 T 17-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SHXM_RS14345 cd6e3578ebd2646d8d8dbcb64aa2847e 103 Gene3D G3DSA:3.30.1360.20 2 95 1.3E-24 T 17-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SHXM_RS14345 cd6e3578ebd2646d8d8dbcb64aa2847e 103 Pfam PF01329 Pterin 4 alpha carbinolamine dehydratase 4 94 1.3E-25 T 17-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SHXM_RS14345 cd6e3578ebd2646d8d8dbcb64aa2847e 103 SUPERFAMILY SSF55248 3 95 2.75E-25 T 17-03-2017 IPR001533 Transcriptional coactivator/pterin dehydratase GO:0006729|GO:0008124 MetaCyc: PWY-7158 SHXM_RS29755 8ee0bd4893215f5db472eaaaeff2bc59 1052 Gene3D G3DSA:3.40.50.300 804 903 7.9E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29755 8ee0bd4893215f5db472eaaaeff2bc59 1052 Pfam PF00271 Helicase conserved C-terminal domain 829 880 1.6E-6 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS29755 8ee0bd4893215f5db472eaaaeff2bc59 1052 SMART SM00490 784 881 9.5E-5 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS29755 8ee0bd4893215f5db472eaaaeff2bc59 1052 SUPERFAMILY SSF52540 588 685 3.83E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29755 8ee0bd4893215f5db472eaaaeff2bc59 1052 SUPERFAMILY SSF52540 740 891 3.83E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29755 8ee0bd4893215f5db472eaaaeff2bc59 1052 SUPERFAMILY SSF52540 426 483 3.83E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Pfam PF00754 F5/8 type C domain 456 577 5.5E-9 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 SUPERFAMILY SSF49785 856 976 2.66E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 SUPERFAMILY SSF51445 36 343 6.74E-24 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Pfam PF16990 Carbohydrate binding module (family 35) 642 714 5.5E-7 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 761 829 1.6E-8 T 17-03-2017 IPR018905 Alpha-galactosidase, NEW3 domain SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Pfam PF01120 Alpha-L-fucosidase 79 336 2.0E-11 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Gene3D G3DSA:2.60.120.260 609 729 2.3E-8 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Gene3D G3DSA:2.60.120.260 857 977 4.4E-11 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 SMART SM00812 29 398 2.6E-6 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Gene3D G3DSA:3.20.20.80 33 343 2.9E-28 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 SUPERFAMILY SSF49785 609 730 2.04E-5 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Gene3D G3DSA:2.60.40.10 761 828 9.0E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 SUPERFAMILY SSF49785 456 579 5.32E-16 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41385 d3406db5daae6e8e4e1a813ec1865815 979 Gene3D G3DSA:2.60.120.260 435 599 2.5E-25 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 Gene3D G3DSA:3.40.30.10 6 110 2.9E-31 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 ProSitePatterns PS00194 Thioredoxin family active site. 29 47 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 SUPERFAMILY SSF52833 3 111 2.53E-34 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 PIRSF PIRSF000077 7 112 1.9E-35 T 17-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 PRINTS PR00421 Thioredoxin family signature 28 36 2.8E-7 T 17-03-2017 SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 PRINTS PR00421 Thioredoxin family signature 36 45 2.8E-7 T 17-03-2017 SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 PRINTS PR00421 Thioredoxin family signature 76 87 2.8E-7 T 17-03-2017 SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 TIGRFAM TIGR01068 thioredoxin: thioredoxin 13 110 1.5E-30 T 17-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SHXM_RS27930 5271b9ab8515a96999a44f10938fa60d 112 Pfam PF00085 Thioredoxin 9 109 1.3E-28 T 17-03-2017 IPR013766 Thioredoxin domain GO:0045454 SHXM_RS10945 5b08abc2d2c97844fcf79bc74f1401c1 185 Pfam PF03358 NADPH-dependent FMN reductase 3 143 3.6E-30 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS10945 5b08abc2d2c97844fcf79bc74f1401c1 185 TIGRFAM TIGR03567 FMN_reduc_SsuE: FMN reductase 3 171 5.8E-66 T 17-03-2017 IPR020048 NADPH-dependent FMN reductase, SsuE GO:0008752|GO:0046306|GO:0055114 KEGG: 00740+1.5.1.38|MetaCyc: PWY-7723 SHXM_RS10945 5b08abc2d2c97844fcf79bc74f1401c1 185 Gene3D G3DSA:3.40.50.360 1 173 1.8E-34 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS10945 5b08abc2d2c97844fcf79bc74f1401c1 185 SUPERFAMILY SSF52218 3 170 2.95E-34 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 148 175 - T 17-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 113 283 9.8E-49 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 Gene3D G3DSA:3.40.50.720 17 113 2.2E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 SUPERFAMILY SSF51735 104 284 9.42E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 SUPERFAMILY SSF52283 18 137 2.84E-26 T 17-03-2017 SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 19 305 5.8E-22 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS42195 2ee695e64261803cd72aa721190b04d7 309 Gene3D G3DSA:3.40.50.720 114 285 2.7E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50660 eb0939f997f86907916f0c016b7ca89e 125 Pfam PF12680 SnoaL-like domain 11 110 2.6E-7 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS50660 eb0939f997f86907916f0c016b7ca89e 125 SUPERFAMILY SSF54427 1 116 7.97E-13 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS50660 eb0939f997f86907916f0c016b7ca89e 125 Gene3D G3DSA:3.10.450.50 2 117 4.9E-10 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 SUPERFAMILY SSF46689 284 334 1.66E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 Gene3D G3DSA:1.10.10.60 239 283 2.2E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 Gene3D G3DSA:1.10.10.60 284 333 4.0E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 Gene3D G3DSA:3.40.50.880 24 238 2.6E-47 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 SUPERFAMILY SSF46689 232 280 5.12E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 SUPERFAMILY SSF52317 24 212 1.53E-45 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 SMART SM00342 247 330 1.1E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 Pfam PF12833 Helix-turn-helix domain 253 331 7.0E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS22660 4b201b60b67ffd7231375a815805af74 440 Pfam PF01965 DJ-1/PfpI family 60 191 3.7E-14 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS01895 6b14ead30c63ef9ee48554d0cf4705b5 357 Pfam PF00296 Luciferase-like monooxygenase 4 329 1.9E-69 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01895 6b14ead30c63ef9ee48554d0cf4705b5 357 Gene3D G3DSA:3.20.20.30 3 354 1.1E-85 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01895 6b14ead30c63ef9ee48554d0cf4705b5 357 SUPERFAMILY SSF51679 2 354 4.06E-74 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Pfam PF01612 3'-5' exonuclease 368 458 1.6E-4 T 17-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SUPERFAMILY SSF53098 335 502 4.05E-29 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Pfam PF00476 DNA polymerase family A 535 908 2.2E-141 T 17-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 TIGRFAM TIGR00593 pola: DNA polymerase I 24 910 3.9E-297 T 17-03-2017 IPR018320 DNA polymerase 1 GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold 193 285 1.3E-27 T 17-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 23 191 8.1E-55 T 17-03-2017 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SUPERFAMILY SSF56672 508 909 1.78E-138 T 17-03-2017 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SMART SM00482 668 875 5.6E-114 T 17-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:3.30.70.370 802 910 3.8E-63 T 17-03-2017 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:3.30.70.370 646 694 3.8E-63 T 17-03-2017 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:1.20.1060.10 527 645 5.0E-33 T 17-03-2017 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SUPERFAMILY SSF47807 192 300 1.94E-29 T 17-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:3.40.50.1010 23 206 1.1E-68 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:1.10.150.20 695 801 7.5E-33 T 17-03-2017 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SMART SM00475 20 282 5.0E-142 T 17-03-2017 IPR002421 5'-3' exonuclease, N-terminal GO:0003677 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SUPERFAMILY SSF88723 21 191 1.65E-53 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:1.10.150.20 207 266 4.7E-26 T 17-03-2017 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 Gene3D G3DSA:3.30.420.10 335 525 7.1E-48 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SMART SM00474 329 501 3.8E-7 T 17-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 SMART SM00279 194 229 3.7E-14 T 17-03-2017 IPR008918 Helix-hairpin-helix motif, class 2 GO:0003677|GO:0003824 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 796 807 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 737 762 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 858 871 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 637 659 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 713 726 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 774 785 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 683 706 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 660 675 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18130 b048cbd710d2832c40541fa3258efe2e 912 PRINTS PR00868 DNA-polymerase family A (pol I) signature 828 844 7.7E-76 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS03300 aecd135032050f5bf9ec1bf8538e3de0 222 SUPERFAMILY SSF141571 33 206 1.77E-27 T 17-03-2017 SHXM_RS03300 aecd135032050f5bf9ec1bf8538e3de0 222 Pfam PF13599 Pentapeptide repeats (9 copies) 92 174 3.7E-10 T 17-03-2017 IPR001646 Pentapeptide repeat SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 Pfam PF02754 Cysteine-rich domain 615 702 1.2E-19 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 Pfam PF02754 Cysteine-rich domain 478 576 2.0E-13 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 SUPERFAMILY SSF46548 376 421 1.71E-21 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 SUPERFAMILY SSF46548 287 338 1.71E-21 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 Pfam PF13183 4Fe-4S dicluster domain 299 407 3.9E-14 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 Gene3D G3DSA:1.10.1060.10 372 422 2.7E-32 T 17-03-2017 SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 Gene3D G3DSA:1.10.1060.10 277 335 2.7E-32 T 17-03-2017 SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 393 404 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS29080 4eaa6d994aa166a026fab7825a3e7c15 754 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 302 313 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS10695 a6a2d98948781b93223ac7904217d606 262 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 103 123 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS10695 a6a2d98948781b93223ac7904217d606 262 Gene3D G3DSA:3.90.226.10 2 201 1.8E-51 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS10695 a6a2d98948781b93223ac7904217d606 262 Gene3D G3DSA:1.10.12.10 204 262 4.0E-17 T 17-03-2017 IPR014748 Crontonase, C-terminal SHXM_RS10695 a6a2d98948781b93223ac7904217d606 262 SUPERFAMILY SSF52096 2 262 3.96E-71 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS10695 a6a2d98948781b93223ac7904217d606 262 Pfam PF00378 Enoyl-CoA hydratase/isomerase 12 261 9.4E-43 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 21 164 6.6E-15 T 17-03-2017 SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 Gene3D G3DSA:3.40.50.720 1 196 1.2E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 SUPERFAMILY SSF51735 1 196 7.44E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 162 2.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 55 66 2.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 145 2.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15130 19ef316d1cfbd517a69bc3cde1b0d46a 198 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 2 19 2.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SMART SM00065 401 564 2.9E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Pfam PF08448 PAS fold 287 382 5.8E-7 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SUPERFAMILY SSF55785 164 274 4.36E-18 T 17-03-2017 IPR000014 PAS domain SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Gene3D G3DSA:3.30.450.20 276 381 8.8E-17 T 17-03-2017 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 613 754 6.2E-47 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SUPERFAMILY SSF55785 277 371 2.09E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Gene3D G3DSA:3.30.450.20 160 271 2.4E-19 T 17-03-2017 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Gene3D G3DSA:3.30.450.40 391 570 1.3E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Pfam PF08447 PAS fold 182 265 2.5E-18 T 17-03-2017 IPR013655 PAS fold-3 GO:0005515 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SMART SM00091 158 225 0.0028 T 17-03-2017 IPR000014 PAS domain SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SMART SM00091 278 342 6.9E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SMART SM00086 231 273 7.8E-6 T 17-03-2017 IPR001610 PAC motif SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SMART SM00331 585 822 3.7E-34 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SUPERFAMILY SSF55781 398 561 2.18E-14 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 204 278 7.9E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 Pfam PF13185 GAF domain 414 554 1.6E-9 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS04490 8c56c625ce3c3d93e0855df6448ad034 954 SUPERFAMILY SSF81606 599 748 2.2E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 Pfam PF00754 F5/8 type C domain 888 1000 1.2E-18 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 Pfam PF07555 beta-N-acetylglucosaminidase 206 513 2.8E-99 T 17-03-2017 IPR011496 Beta-N-acetylglucosaminidase MetaCyc: PWY-7437 SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 SUPERFAMILY SSF140657 525 647 6.54E-19 T 17-03-2017 SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 Gene3D G3DSA:3.30.379.10 51 200 1.1E-19 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 Gene3D G3DSA:2.60.120.260 883 1007 2.2E-21 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 SUPERFAMILY SSF49785 881 1005 3.12E-19 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 55 200 1.1E-20 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 SUPERFAMILY SSF51445 204 507 1.26E-86 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21890 fcf3b4b6b82b39ebce5012e4fd49de41 1010 SUPERFAMILY SSF55545 55 201 1.7E-13 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS01160 1805e76f188127512f82ccfedd17cf64 215 Gene3D G3DSA:3.10.450.50 27 120 6.1E-21 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS01160 1805e76f188127512f82ccfedd17cf64 215 Pfam PF07366 SnoaL-like polyketide cyclase 33 118 9.5E-17 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS01160 1805e76f188127512f82ccfedd17cf64 215 SUPERFAMILY SSF54427 25 118 2.25E-18 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PRINTS PR00088 Haem oxygenase signature 191 209 2.3E-31 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PRINTS PR00088 Haem oxygenase signature 115 136 2.3E-31 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PRINTS PR00088 Haem oxygenase signature 159 180 2.3E-31 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PRINTS PR00088 Haem oxygenase signature 2 27 2.3E-31 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PRINTS PR00088 Haem oxygenase signature 37 62 2.3E-31 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PRINTS PR00088 Haem oxygenase signature 62 87 2.3E-31 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 PIRSF PIRSF000343 1 214 1.2E-64 T 17-03-2017 IPR002051 Haem oxygenase GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 Gene3D G3DSA:1.20.910.10 2 207 5.1E-60 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 SUPERFAMILY SSF48613 2 208 8.6E-56 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS19485 43bab4d20d680d5f5118e7ef75c8d225 214 Pfam PF01126 Heme oxygenase 2 205 2.8E-60 T 17-03-2017 IPR016053 Haem oxygenase-like GO:0004392|GO:0006788|GO:0055114 KEGG: 00860+1.14.14.18|Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS07895 532057111bf2fed26bb0b764b8cb9f80 314 SUPERFAMILY SSF53850 62 293 1.59E-34 T 17-03-2017 SHXM_RS07895 532057111bf2fed26bb0b764b8cb9f80 314 Gene3D G3DSA:3.40.190.10 255 292 8.5E-19 T 17-03-2017 SHXM_RS07895 532057111bf2fed26bb0b764b8cb9f80 314 Gene3D G3DSA:3.40.190.10 62 140 8.5E-19 T 17-03-2017 SHXM_RS07895 532057111bf2fed26bb0b764b8cb9f80 314 Gene3D G3DSA:3.40.190.10 141 237 4.2E-12 T 17-03-2017 SHXM_RS07895 532057111bf2fed26bb0b764b8cb9f80 314 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 65 292 4.7E-33 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS07895 532057111bf2fed26bb0b764b8cb9f80 314 SMART SM00062 64 295 5.5E-19 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS11410 7263230eb317a28acebf59c63d76effd 522 Gene3D G3DSA:3.30.420.40 259 501 3.9E-16 T 17-03-2017 SHXM_RS11410 7263230eb317a28acebf59c63d76effd 522 SUPERFAMILY SSF53067 256 499 7.51E-34 T 17-03-2017 SHXM_RS11410 7263230eb317a28acebf59c63d76effd 522 Gene3D G3DSA:3.30.420.40 5 250 5.2E-26 T 17-03-2017 SHXM_RS11410 7263230eb317a28acebf59c63d76effd 522 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 259 462 7.0E-31 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS11410 7263230eb317a28acebf59c63d76effd 522 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 10 250 2.6E-30 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS11410 7263230eb317a28acebf59c63d76effd 522 SUPERFAMILY SSF53067 8 247 6.02E-44 T 17-03-2017 SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 ProSitePatterns PS00194 Thioredoxin family active site. 62 80 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 PRINTS PR00421 Thioredoxin family signature 69 78 4.7E-6 T 17-03-2017 SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 PRINTS PR00421 Thioredoxin family signature 61 69 4.7E-6 T 17-03-2017 SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 PRINTS PR00421 Thioredoxin family signature 109 120 4.7E-6 T 17-03-2017 SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 Gene3D G3DSA:3.40.30.10 45 144 3.9E-33 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 SUPERFAMILY SSF52833 42 146 3.96E-34 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 TIGRFAM TIGR01068 thioredoxin: thioredoxin 47 143 1.6E-32 T 17-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SHXM_RS40035 f428d9b6b5244b722ea7c9f1001faf9d 154 Pfam PF00085 Thioredoxin 45 143 1.3E-26 T 17-03-2017 IPR013766 Thioredoxin domain GO:0045454 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 Gene3D G3DSA:1.25.40.10 523 587 1.7E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 Gene3D G3DSA:1.25.40.10 655 710 1.7E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 213 231 4.5E-6 T 17-03-2017 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 165 183 4.5E-6 T 17-03-2017 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 17 36 4.5E-6 T 17-03-2017 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 SUPERFAMILY SSF51905 15 249 6.47E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 Pfam PF13454 FAD-NAD(P)-binding 18 173 5.0E-35 T 17-03-2017 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 Gene3D G3DSA:3.50.50.60 16 246 2.9E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 SUPERFAMILY SSF48452 523 581 2.53E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42620 10222a3bff9cb71631e4d919d942f2c7 919 SUPERFAMILY SSF48452 654 712 2.53E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 166 4.5E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 4.5E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 195 4.5E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 95 106 4.5E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 Gene3D G3DSA:3.40.50.720 5 273 1.8E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 SUPERFAMILY SSF51735 5 264 6.85E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 164 7.2E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 95 106 7.2E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 176 195 7.2E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 9 211 0.0035 T 17-03-2017 SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 Pfam PF00106 short chain dehydrogenase 9 215 9.8E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19730 e4873ff82af0bd6c45a0dee3307c1016 314 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 163 191 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 Gene3D G3DSA:3.40.50.970 70 482 3.4E-146 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 TIGRFAM TIGR00759 aceE: pyruvate dehydrogenase (acetyl-transferring), homodimeric type 19 902 0.0 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 SUPERFAMILY SSF52518 487 716 1.46E-86 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 Gene3D G3DSA:3.40.50.920 723 897 2.8E-69 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 Gene3D G3DSA:3.40.50.970 487 720 1.3E-110 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 SUPERFAMILY SSF52518 70 481 1.29E-122 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 373 438 1.9E-4 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 149 306 5.6E-8 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 PIRSF PIRSF000156 10 903 0.0 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS20235 11d249b998c678b5b1487cee4166ef67 909 SUPERFAMILY SSF52922 719 894 4.04E-54 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 SUPERFAMILY SSF54814 180 258 1.77E-27 T 17-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 SUPERFAMILY SSF54814 259 324 2.49E-15 T 17-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 SUPERFAMILY SSF50249 112 179 6.86E-14 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Gene3D G3DSA:2.40.50.140 109 178 1.5E-23 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 SUPERFAMILY SSF69705 3 102 4.58E-27 T 17-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Pfam PF08529 NusA N-terminal domain 6 63 3.3E-9 T 17-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Pfam PF08529 NusA N-terminal domain 62 103 2.8E-7 T 17-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Gene3D G3DSA:3.30.300.20 258 325 7.0E-30 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Pfam PF13184 NusA-like KH domain 210 278 6.4E-26 T 17-03-2017 IPR025249 KH domain, NusA-like GO:0003723 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Hamap MF_00945_B Transcription termination/antitermination protein NusA [nusA]. 1 330 25.742 T 17-03-2017 IPR030842 Transcription termination/antitermination protein NusA, bacterial GO:0006353|GO:0031564 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 TIGRFAM TIGR01953 NusA: transcription termination factor NusA 5 322 2.5E-105 T 17-03-2017 IPR010213 Transcription termination factor NusA GO:0003723 SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Gene3D G3DSA:3.30.300.20 179 257 4.4E-33 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS36915 07aad6375c12894cc6cfce3a5ecfef55 330 Gene3D G3DSA:3.30.1480.10 3 102 2.5E-30 T 17-03-2017 IPR013735 Transcription factor NusA, N-terminal GO:0003700|GO:0031554 SHXM_RS34295 da97f66c376eb84ff7e08f37e714bb17 80 Gene3D G3DSA:3.40.30.10 4 77 5.4E-20 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS34295 da97f66c376eb84ff7e08f37e714bb17 80 ProSitePatterns PS00194 Thioredoxin family active site. 5 23 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS34295 da97f66c376eb84ff7e08f37e714bb17 80 TIGRFAM TIGR02200 GlrX_actino: glutaredoxin-like protein 4 78 9.7E-33 T 17-03-2017 IPR011915 Glutaredoxin-like protein, actinobacteria SHXM_RS34295 da97f66c376eb84ff7e08f37e714bb17 80 Pfam PF00462 Glutaredoxin 5 60 3.7E-13 T 17-03-2017 IPR002109 Glutaredoxin GO:0009055|GO:0015035|GO:0045454 SHXM_RS34295 da97f66c376eb84ff7e08f37e714bb17 80 SUPERFAMILY SSF52833 4 71 3.5E-16 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS04870 f2d9ba8d3618596b8214227c5294b3cc 198 SUPERFAMILY SSF109604 26 145 2.66E-17 T 17-03-2017 SHXM_RS04870 f2d9ba8d3618596b8214227c5294b3cc 198 TIGRFAM TIGR00277 HDIG: HDIG domain 26 108 4.8E-13 T 17-03-2017 IPR006675 HDIG domain SHXM_RS04870 f2d9ba8d3618596b8214227c5294b3cc 198 Pfam PF01966 HD domain 26 145 1.3E-12 T 17-03-2017 IPR006674 HD domain SHXM_RS04870 f2d9ba8d3618596b8214227c5294b3cc 198 Gene3D G3DSA:1.10.3210.10 26 151 2.7E-17 T 17-03-2017 IPR006674 HD domain SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 Pfam PF00005 ABC transporter 350 475 2.6E-13 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 Pfam PF00005 ABC transporter 21 191 4.8E-20 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 Gene3D G3DSA:3.40.50.300 8 100 3.5E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 Gene3D G3DSA:3.40.50.300 348 526 4.5E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 Gene3D G3DSA:3.40.50.300 136 272 3.5E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 SUPERFAMILY SSF52540 7 82 1.31E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 SUPERFAMILY SSF52540 132 232 1.31E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 SMART SM00382 356 536 3.8E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 SMART SM00382 29 236 4.1E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS44055 fe212ded98ca208511b7a3d08d6cfc99 539 SUPERFAMILY SSF52540 348 522 6.23E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 6 20 - T 17-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 Gene3D G3DSA:3.40.1010.10 2 110 1.2E-34 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 SUPERFAMILY SSF53790 2 233 1.83E-61 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2. 76 109 - T 17-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 Gene3D G3DSA:3.30.950.10 111 232 3.3E-33 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 2 208 2.2E-40 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07325 090974bfecaeb4167d97676321d4ce65 256 TIGRFAM TIGR01465 cobM_cbiF: precorrin-4 C11-methyltransferase 3 243 9.0E-89 T 17-03-2017 IPR006362 Cobalamin (vitamin B12) biosynthesis CobM/CbiF, precorrin-4 C11-methyltransferase GO:0009236|GO:0046026 SHXM_RS50315 fa556e0191407af295d1d324721e0bda 294 Pfam PF01418 Helix-turn-helix domain, rpiR family 20 87 1.9E-15 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS50315 fa556e0191407af295d1d324721e0bda 294 Gene3D G3DSA:3.40.50.10490 120 274 2.2E-31 T 17-03-2017 SHXM_RS50315 fa556e0191407af295d1d324721e0bda 294 Gene3D G3DSA:1.10.10.10 13 87 1.8E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50315 fa556e0191407af295d1d324721e0bda 294 Pfam PF01380 SIS domain 140 267 4.4E-13 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS50315 fa556e0191407af295d1d324721e0bda 294 SUPERFAMILY SSF53697 113 283 7.86E-33 T 17-03-2017 SHXM_RS50315 fa556e0191407af295d1d324721e0bda 294 SUPERFAMILY SSF46689 12 86 5.38E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48495 a9792959adf4c94c487a8109750d15b0 208 Gene3D G3DSA:1.20.910.10 1 205 3.0E-32 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS48495 a9792959adf4c94c487a8109750d15b0 208 SUPERFAMILY SSF48613 1 206 7.56E-31 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 Gene3D G3DSA:2.40.10.10 260 344 3.5E-27 T 17-03-2017 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 Gene3D G3DSA:3.30.300.50 102 167 1.2E-5 T 17-03-2017 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 285 299 1.7E-42 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 413 427 1.7E-42 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 389 412 1.7E-42 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 369 386 1.7E-42 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 348 368 1.7E-42 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 Gene3D G3DSA:2.40.10.10 345 435 2.0E-29 T 17-03-2017 SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 SUPERFAMILY SSF50494 265 441 1.09E-34 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS06880 e3456d40e52661219828a6377192dbc0 542 Pfam PF02983 Alpha-lytic protease prodomain 101 153 3.8E-14 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 97 150 3.3E-12 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 17 67 9.6E-12 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 SMART SM00382 203 348 2.9E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 SMART SM00382 605 750 3.0E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 SUPERFAMILY SSF81923 4 160 3.04E-42 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 683 701 1.4E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 716 730 1.4E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 609 627 1.4E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 654 672 1.4E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 639 657 - T 17-03-2017 IPR028299 ClpA/B, conserved site 2 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 SUPERFAMILY SSF52540 554 864 2.62E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 208 340 3.5E-11 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Gene3D G3DSA:1.10.1780.10 1 153 5.2E-46 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Gene3D G3DSA:3.40.50.300 560 787 1.5E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Gene3D G3DSA:3.40.50.300 164 347 1.2E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 TIGRFAM TIGR03346 chaperone_ClpB: ATP-dependent chaperone protein ClpB 6 865 0.0 T 17-03-2017 IPR017730 Chaperonin ClpB GO:0005737|GO:0009408|GO:0016485 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Pfam PF07724 AAA domain (Cdc48 subfamily) 604 770 5.0E-54 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Gene3D G3DSA:1.10.8.60 348 432 5.4E-35 T 17-03-2017 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 SUPERFAMILY SSF52540 164 553 1.99E-93 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 SMART SM01086 776 865 2.9E-33 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 776 856 1.9E-23 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 Gene3D G3DSA:1.10.8.60 788 877 1.5E-30 T 17-03-2017 SHXM_RS40030 4dbdc296b09a8854516426dab1957a82 887 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 299 311 - T 17-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 SHXM_RS33590 f78a4e09014d7c8f654146e78cbb037f 217 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 65 8.8E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33590 f78a4e09014d7c8f654146e78cbb037f 217 SUPERFAMILY SSF48498 87 214 3.6E-31 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS33590 f78a4e09014d7c8f654146e78cbb037f 217 Gene3D G3DSA:1.10.357.10 1 215 4.4E-46 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS33590 f78a4e09014d7c8f654146e78cbb037f 217 SUPERFAMILY SSF46689 9 91 3.33E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS33590 f78a4e09014d7c8f654146e78cbb037f 217 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 6.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS33590 f78a4e09014d7c8f654146e78cbb037f 217 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 21 34 6.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS09980 07044a73a9915ce105e7d43fd08278e9 364 Pfam PF13565 Homeodomain-like domain 53 132 2.1E-14 T 17-03-2017 SHXM_RS09980 07044a73a9915ce105e7d43fd08278e9 364 SUPERFAMILY SSF53098 204 335 1.26E-5 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09980 07044a73a9915ce105e7d43fd08278e9 364 Gene3D G3DSA:3.30.420.10 203 334 4.9E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09980 07044a73a9915ce105e7d43fd08278e9 364 Pfam PF13358 DDE superfamily endonuclease 173 315 3.9E-27 T 17-03-2017 SHXM_RS09980 07044a73a9915ce105e7d43fd08278e9 364 Gene3D G3DSA:1.10.10.10 25 65 1.7E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09980 07044a73a9915ce105e7d43fd08278e9 364 SUPERFAMILY SSF46689 24 134 5.38E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS43850 acef2650191ef36a526989f39fd2e3e5 266 PIRSF PIRSF026671 9 264 2.9E-70 T 17-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 SHXM_RS43850 acef2650191ef36a526989f39fd2e3e5 266 Pfam PF01427 D-ala-D-ala dipeptidase 191 259 1.3E-11 T 17-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 SHXM_RS43850 acef2650191ef36a526989f39fd2e3e5 266 Pfam PF01427 D-ala-D-ala dipeptidase 38 161 2.1E-13 T 17-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 SHXM_RS43850 acef2650191ef36a526989f39fd2e3e5 266 SUPERFAMILY SSF55166 36 259 9.02E-59 T 17-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 SHXM_RS43850 acef2650191ef36a526989f39fd2e3e5 266 Hamap MF_01924 D-alanyl-D-alanine dipeptidase [ddpX]. 38 258 30.739 T 17-03-2017 IPR000755 D-alanyl-D-alanine dipeptidase GO:0005618|GO:0006508|GO:0008237|GO:0016805 MetaCyc: PWY-6454|MetaCyc: PWY-6455 SHXM_RS43850 acef2650191ef36a526989f39fd2e3e5 266 Gene3D G3DSA:3.30.1380.10 36 259 7.7E-70 T 17-03-2017 IPR009045 Hedgehog signalling/DD-peptidase zinc-binding domain Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 SHXM_RS25070 84586821d609eec24c79468dbf7f5c8f 529 SUPERFAMILY SSF51703 3 523 5.49E-204 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS25070 84586821d609eec24c79468dbf7f5c8f 529 Pfam PF01642 Methylmalonyl-CoA mutase 6 521 2.4E-217 T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS25070 84586821d609eec24c79468dbf7f5c8f 529 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 5 524 1.4E-230 T 17-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS25070 84586821d609eec24c79468dbf7f5c8f 529 Gene3D G3DSA:3.20.20.240 5 523 9.3E-222 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Gene3D G3DSA:2.60.40.1120 685 765 3.5E-13 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Gene3D G3DSA:2.60.40.1120 603 679 8.9E-8 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 PRINTS PR01036 Tetracycline resistance protein TetB signature 195 219 6.4E-5 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 PRINTS PR01036 Tetracycline resistance protein TetB signature 165 185 6.4E-5 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 PRINTS PR01036 Tetracycline resistance protein TetB signature 75 99 6.4E-5 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Gene3D G3DSA:2.60.40.10 771 822 9.6E-11 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Pfam PF07690 Major Facilitator Superfamily 76 469 6.0E-55 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 SUPERFAMILY SSF103473 306 478 9.42E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 SUPERFAMILY SSF103473 531 555 9.42E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 SUPERFAMILY SSF103473 58 256 9.42E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 72 480 1.4E-83 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 SUPERFAMILY SSF49478 769 836 1.96E-10 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Gene3D G3DSA:1.20.1250.20 322 493 5.7E-17 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Gene3D G3DSA:1.20.1250.20 536 559 5.7E-17 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Gene3D G3DSA:1.20.1250.20 71 252 1.2E-32 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 SUPERFAMILY SSF49464 602 679 3.1E-9 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 SUPERFAMILY SSF49464 685 773 4.71E-12 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Pfam PF13620 Carboxypeptidase regulatory-like domain 604 679 2.3E-9 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Pfam PF13620 Carboxypeptidase regulatory-like domain 769 845 9.5E-12 T 17-03-2017 SHXM_RS14690 3160502c9951a712d0097c859142ede8 849 Pfam PF13620 Carboxypeptidase regulatory-like domain 685 763 1.1E-14 T 17-03-2017 SHXM_RS41895 481174c2385bf75f525f41b353ff37f0 450 SUPERFAMILY SSF103473 17 447 1.31E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS41895 481174c2385bf75f525f41b353ff37f0 450 Pfam PF07690 Major Facilitator Superfamily 284 438 1.9E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS41895 481174c2385bf75f525f41b353ff37f0 450 Pfam PF00083 Sugar (and other) transporter 35 237 3.0E-23 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS41895 481174c2385bf75f525f41b353ff37f0 450 Gene3D G3DSA:1.20.1250.20 30 231 3.7E-22 T 17-03-2017 SHXM_RS41895 481174c2385bf75f525f41b353ff37f0 450 Gene3D G3DSA:1.20.1250.20 255 442 1.0E-21 T 17-03-2017 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 172 184 1.0E-12 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 338 351 1.0E-12 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 197 211 1.0E-12 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 279 287 1.0E-12 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 SUPERFAMILY SSF53187 144 449 1.05E-85 T 17-03-2017 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 ProSitePatterns PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 197 219 - T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 ProSitePatterns PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 341 351 - T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 Gene3D G3DSA:3.40.630.10 143 455 2.9E-99 T 17-03-2017 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 Pfam PF00246 Zinc carboxypeptidase 156 440 3.8E-71 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS33420 a5df27fc368d6e37184a8954288f32b8 465 SMART SM00631 146 437 4.4E-100 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS12220 844194a1633d9d0ccb053967138e11e5 294 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 186 6.2E-24 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS12220 844194a1633d9d0ccb053967138e11e5 294 Gene3D G3DSA:3.40.50.720 4 283 4.9E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12220 844194a1633d9d0ccb053967138e11e5 294 SUPERFAMILY SSF51735 2 283 2.86E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 SUPERFAMILY SSF46689 212 253 5.38E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 SUPERFAMILY SSF51182 23 168 1.67E-10 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 Pfam PF02311 AraC-like ligand binding domain 22 118 7.2E-6 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 Gene3D G3DSA:1.10.10.60 152 205 5.0E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 SMART SM00342 170 252 3.4E-16 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 Gene3D G3DSA:2.60.120.10 24 86 1.5E-6 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 Gene3D G3DSA:1.10.10.60 217 253 5.7E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41170 3ce2aba3f0837b5afd16753875f44cd8 263 Pfam PF12833 Helix-turn-helix domain 176 252 5.8E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 Gene3D G3DSA:3.40.50.720 4 248 4.0E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8 230 0.0027 T 17-03-2017 SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 Pfam PF00106 short chain dehydrogenase 9 206 8.5E-59 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 149 177 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 1.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 162 181 1.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 1.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 SUPERFAMILY SSF51735 4 240 5.6E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 181 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 183 200 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47595 8af91ab4d5c5a7d1bcb14695fe3f9d05 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS28475 9c8c12ebe59082044a31f75da61fdeca 329 SUPERFAMILY SSF54001 211 296 5.89E-6 T 17-03-2017 SHXM_RS28475 9c8c12ebe59082044a31f75da61fdeca 329 Gene3D G3DSA:3.90.1720.10 191 295 3.6E-7 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 ProSitePatterns PS00646 Ribosomal protein S13 signature. 88 101 - T 17-03-2017 IPR018269 Ribosomal protein S13, conserved site GO:0003723|GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 PIRSF PIRSF002134 1 125 3.2E-41 T 17-03-2017 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 TIGRFAM TIGR03631 uS13_bact: ribosomal protein uS13 3 115 2.2E-50 T 17-03-2017 IPR019980 Ribosomal protein S13, bacterial-type GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 Gene3D G3DSA:1.10.8.50 1 72 4.9E-29 T 17-03-2017 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 Gene3D G3DSA:4.10.910.10 73 124 3.8E-25 T 17-03-2017 IPR027437 30s ribosomal protein S13, C-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 SUPERFAMILY SSF46946 2 122 3.01E-43 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 Pfam PF00416 Ribosomal protein S13/S18 3 109 5.0E-30 T 17-03-2017 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31295 1c7e7ae3069c06aa363bf52bad3d22ee 126 Hamap MF_01315 30S ribosomal protein S13 [rpsM]. 1 120 27.018 T 17-03-2017 IPR001892 Ribosomal protein S13 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS15935 25cbaa6774ccd2bb09f89cb151129162 107 PRINTS PR00352 3Fe-4S ferredoxin signature 24 35 1.1E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS15935 25cbaa6774ccd2bb09f89cb151129162 107 PRINTS PR00352 3Fe-4S ferredoxin signature 78 90 1.1E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS15935 25cbaa6774ccd2bb09f89cb151129162 107 PRINTS PR00352 3Fe-4S ferredoxin signature 35 45 1.1E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS15935 25cbaa6774ccd2bb09f89cb151129162 107 SUPERFAMILY SSF54862 21 92 2.32E-9 T 17-03-2017 SHXM_RS15935 25cbaa6774ccd2bb09f89cb151129162 107 Pfam PF13459 4Fe-4S single cluster domain 22 92 2.3E-19 T 17-03-2017 SHXM_RS15935 25cbaa6774ccd2bb09f89cb151129162 107 Gene3D G3DSA:3.30.70.20 20 104 2.0E-27 T 17-03-2017 SHXM_RS16135 207ba203cb58e030dcfad4161b6bf6b5 283 Pfam PF13560 Helix-turn-helix domain 5 84 9.3E-16 T 17-03-2017 SHXM_RS16135 207ba203cb58e030dcfad4161b6bf6b5 283 SUPERFAMILY SSF47413 6 77 1.18E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS16135 207ba203cb58e030dcfad4161b6bf6b5 283 SMART SM00530 9 81 1.5E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS16135 207ba203cb58e030dcfad4161b6bf6b5 283 Gene3D G3DSA:1.10.260.40 3 80 1.7E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 SUPERFAMILY SSF55447 225 324 2.75E-25 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 SMART SM01092 227 326 5.1E-24 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 229 320 1.4E-18 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 Gene3D G3DSA:3.30.43.10 1 51 1.7E-17 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 SUPERFAMILY SSF56176 1 220 2.07E-57 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 Gene3D G3DSA:3.30.390.50 225 328 1.1E-30 T 17-03-2017 SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 Gene3D G3DSA:3.30.465.10 157 220 2.3E-30 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 Gene3D G3DSA:3.30.465.10 59 113 2.3E-30 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS06265 f6df0700ecd37f44cf38cebce5b6be97 333 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 220 8.3E-46 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS40920 94ffca9de96a8156c4e832286649916c 66 Pfam PF11755 Protein of unknown function (DUF3311) 7 64 2.4E-19 T 17-03-2017 IPR021741 Protein of unknown function DUF3311 SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 SUPERFAMILY SSF88946 7 82 5.1E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 SUPERFAMILY SSF54427 168 283 5.49E-14 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 Gene3D G3DSA:1.10.1740.10 6 71 1.8E-10 T 17-03-2017 SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 Gene3D G3DSA:1.10.10.10 109 157 3.3E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 Pfam PF04542 Sigma-70 region 2 7 69 3.0E-11 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 Pfam PF08281 Sigma-70, region 4 105 156 1.4E-10 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 Gene3D G3DSA:3.10.450.50 166 283 1.7E-12 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 157 3.4E-14 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 TIGRFAM TIGR02957 SigX4: RNA polymerase sigma-70 factor, TIGR02957 family 5 286 2.2E-110 T 17-03-2017 IPR014303 RNA polymerase sigma-70, ECF type SHXM_RS41975 727d08a25abed3aead074631c53c06fd 307 SUPERFAMILY SSF88659 79 158 2.99E-10 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 209 224 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 296 310 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 486 502 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 432 447 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 324 339 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 260 280 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 374 396 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PRINTS PR00743 Glycosyl hydrolase family 36 signature 511 527 1.8E-43 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 Pfam PF16874 Glycosyl hydrolase family 36 C-terminal domain 644 693 1.2E-10 T 17-03-2017 IPR031705 Glycosyl hydrolase family 36, C-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 Pfam PF02065 Melibiase 257 601 2.4E-98 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 Gene3D G3DSA:3.20.20.70 291 582 5.8E-41 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 PIRSF PIRSF005536 78 696 1.2E-152 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 SUPERFAMILY SSF51445 291 617 1.24E-81 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38030 27c31cdff5e5b1d7dafff69b7246bd37 696 Pfam PF16875 Glycosyl hydrolase family 36 N-terminal domain 97 252 3.8E-29 T 17-03-2017 IPR031704 Glycosyl hydrolase family 36, N-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 Gene3D G3DSA:1.10.10.60 199 253 6.6E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 Gene3D G3DSA:2.60.120.10 39 76 1.1E-4 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 Pfam PF12852 Cupin 2 186 1.0E-45 T 17-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 SUPERFAMILY SSF46689 201 249 2.12E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 SUPERFAMILY SSF51182 31 75 8.27E-6 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 Gene3D G3DSA:1.10.10.60 254 301 4.0E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 SMART SM00342 216 299 1.3E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 Pfam PF12833 Helix-turn-helix domain 222 300 3.5E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS02430 982e70758cd67194ef4eb62030cee808 318 SUPERFAMILY SSF46689 252 302 2.87E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 ProSitePatterns PS00055 Ribosomal protein S12 signature. 43 50 - T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 Pfam PF00164 Ribosomal protein S12/S23 3 123 5.9E-43 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 Gene3D G3DSA:2.40.50.140 2 123 8.4E-64 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PIRSF PIRSF002133 1 123 2.4E-53 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 TIGRFAM TIGR00981 rpsL_bact: ribosomal protein uS12 2 123 2.9E-66 T 17-03-2017 IPR005679 Ribosomal protein S12, bacterial-type GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 Hamap MF_00403_B 30S ribosomal protein S12 [rpsL]. 1 123 39.334 T 17-03-2017 IPR005679 Ribosomal protein S12, bacterial-type GO:0003735|GO:0006412|GO:0015935 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 SUPERFAMILY SSF50249 2 123 1.11E-51 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PRINTS PR01034 Ribosomal protein S12 signature 110 122 6.4E-58 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PRINTS PR01034 Ribosomal protein S12 signature 94 110 6.4E-58 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PRINTS PR01034 Ribosomal protein S12 signature 27 42 6.4E-58 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PRINTS PR01034 Ribosomal protein S12 signature 58 77 6.4E-58 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PRINTS PR01034 Ribosomal protein S12 signature 42 57 6.4E-58 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31125 8086c4e7e291a885ce9eb014a90b627d 123 PRINTS PR01034 Ribosomal protein S12 signature 77 94 6.4E-58 T 17-03-2017 IPR006032 Ribosomal protein S12/S23 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 5 25 1.7E-34 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 87 105 1.7E-34 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 70 85 1.7E-34 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 PRINTS PR00326 GTP1/OBG GTP-binding protein family signature 26 44 1.7E-34 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Gene3D G3DSA:3.40.50.300 202 261 8.2E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Gene3D G3DSA:3.40.50.300 3 131 8.2E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 SUPERFAMILY SSF81271 278 362 2.18E-35 T 17-03-2017 IPR012676 TGS-like KEGG: 00970+6.1.1.3 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 SUPERFAMILY SSF52540 3 300 7.85E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 PIRSF PIRSF006641 1 362 7.7E-141 T 17-03-2017 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Hamap MF_00944 Ribosome-binding ATPase YchF [ychF]. 2 362 42.278 T 17-03-2017 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Pfam PF06071 Protein of unknown function (DUF933) 278 361 2.4E-39 T 17-03-2017 IPR013029 Domain of unknown function DUF933 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Gene3D G3DSA:3.10.20.30 262 362 1.1E-45 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 TIGRFAM TIGR00092 TIGR00092: GTP-binding protein YchF 3 362 2.1E-131 T 17-03-2017 IPR004396 Ribosome-binding ATPase YchF/Obg-like ATPase 1 GO:0005525 SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Gene3D G3DSA:1.10.150.300 132 201 4.5E-19 T 17-03-2017 IPR023192 TGS-like domain SHXM_RS33685 bce002e73b86375f1b3dcc9615b01d1c 362 Pfam PF01926 50S ribosome-binding GTPase 5 126 1.2E-22 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 SUPERFAMILY SSF63418 4 103 1.27E-22 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Gene3D G3DSA:3.90.190.20 324 469 3.9E-42 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 TIGRFAM TIGR01143 murF: UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 33 467 1.7E-130 T 17-03-2017 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Pfam PF08245 Mur ligase middle domain 113 302 4.8E-44 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Hamap MF_02019 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [murF]. 4 468 32.812 T 17-03-2017 IPR005863 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase GO:0005524|GO:0005737|GO:0047480|GO:0071555 KEGG: 00300+6.3.2.10|KEGG: 00550+6.3.2.10|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Pfam PF02875 Mur ligase family, glutamate ligase domain 326 410 6.8E-21 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Gene3D G3DSA:3.40.1390.10 24 95 6.2E-24 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 SUPERFAMILY SSF53623 107 318 1.57E-52 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Pfam PF01225 Mur ligase family, catalytic domain 31 100 4.1E-14 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 SUPERFAMILY SSF53244 325 467 5.13E-35 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18585 7305b3e66eff50027531a21e537a9ca8 476 Gene3D G3DSA:3.40.1190.10 96 318 2.5E-69 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS36815 99e1769e6b20faa684d8df39136bf67d 587 Pfam PF07905 Purine catabolism regulatory protein-like family 8 126 6.7E-32 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS36815 99e1769e6b20faa684d8df39136bf67d 587 Pfam PF13556 PucR C-terminal helix-turn-helix domain 522 580 9.2E-23 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 Gene3D G3DSA:2.30.22.10 141 198 4.6E-16 T 17-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 Gene3D G3DSA:3.90.20.20 52 138 6.4E-21 T 17-03-2017 IPR013805 GrpE nucleotide exchange factor, coiled-coil Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 SUPERFAMILY SSF58014 52 141 5.36E-20 T 17-03-2017 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 Pfam PF01025 GrpE 58 197 1.1E-31 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 SUPERFAMILY SSF51064 144 197 1.06E-11 T 17-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 PRINTS PR00773 GrpE protein signature 149 164 9.0E-16 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 PRINTS PR00773 GrpE protein signature 69 85 9.0E-16 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 PRINTS PR00773 GrpE protein signature 97 112 9.0E-16 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 PRINTS PR00773 GrpE protein signature 176 195 9.0E-16 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS19605 3a13a8bbc56e1d20b42560d823660525 199 Hamap MF_01151 Protein GrpE [grpE]. 4 197 15.967 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS44780 6710b229e8330435d75b38ae87da7cdd 399 Gene3D G3DSA:3.40.50.1110 182 393 2.2E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS44780 6710b229e8330435d75b38ae87da7cdd 399 SUPERFAMILY SSF52266 180 397 7.99E-39 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS44780 6710b229e8330435d75b38ae87da7cdd 399 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 185 388 1.3E-23 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS26300 a6d8583ad35cddd6275b6c1ae973f681 173 SUPERFAMILY SSF55729 10 135 1.89E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS26300 a6d8583ad35cddd6275b6c1ae973f681 173 Pfam PF00583 Acetyltransferase (GNAT) family 57 126 1.0E-8 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS26300 a6d8583ad35cddd6275b6c1ae973f681 173 Gene3D G3DSA:3.40.630.30 9 151 6.1E-30 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 SUPERFAMILY SSF46689 4 79 2.24E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 Gene3D G3DSA:1.10.10.60 4 56 1.1E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 SUPERFAMILY SSF48498 79 191 5.19E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 2.1E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 2.1E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 3.9E-19 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47115 28759a14c404cf95fa13b8a536da8fd7 195 Gene3D G3DSA:1.10.357.10 57 193 1.1E-42 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS13365 e8747a94bf137713b4951d1a2c69cf3e 145 Gene3D G3DSA:3.10.450.50 5 144 2.7E-33 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS13365 e8747a94bf137713b4951d1a2c69cf3e 145 SUPERFAMILY SSF54427 4 140 2.08E-31 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS13365 e8747a94bf137713b4951d1a2c69cf3e 145 Pfam PF07366 SnoaL-like polyketide cyclase 10 137 9.8E-27 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Gene3D G3DSA:2.170.190.11 61 165 9.0E-32 T 17-03-2017 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Pfam PF03453 MoeA N-terminal region (domain I and II) 20 202 1.8E-32 T 17-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 212 347 6.4E-30 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 SUPERFAMILY SSF63882 19 211 3.66E-47 T 17-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 SMART SM00852 215 351 1.5E-40 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Gene3D G3DSA:2.40.340.10 373 435 3.2E-18 T 17-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Pfam PF00994 Probable molybdopterin binding domain 216 350 8.8E-26 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Pfam PF03454 MoeA C-terminal region (domain IV) 374 438 3.8E-17 T 17-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 SUPERFAMILY SSF53218 211 354 9.68E-40 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 SUPERFAMILY SSF63867 361 438 2.22E-15 T 17-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Gene3D G3DSA:3.90.105.10 166 196 1.3E-20 T 17-03-2017 SHXM_RS32435 53c6b37a332185ea26b4c5ba8938095b 439 Gene3D G3DSA:3.40.980.10 197 364 5.0E-58 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS47160 e8f10527db28beda8e8f891e6cd8c656 389 Gene3D G3DSA:1.10.10.10 17 81 1.2E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47160 e8f10527db28beda8e8f891e6cd8c656 389 Pfam PF00480 ROK family 101 380 7.8E-30 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS47160 e8f10527db28beda8e8f891e6cd8c656 389 Gene3D G3DSA:3.30.420.40 217 351 1.9E-20 T 17-03-2017 SHXM_RS47160 e8f10527db28beda8e8f891e6cd8c656 389 SUPERFAMILY SSF46785 11 77 8.53E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47160 e8f10527db28beda8e8f891e6cd8c656 389 SUPERFAMILY SSF53067 88 381 1.41E-34 T 17-03-2017 SHXM_RS47160 e8f10527db28beda8e8f891e6cd8c656 389 Gene3D G3DSA:3.30.420.40 84 216 2.3E-30 T 17-03-2017 SHXM_RS33665 8920e2f018bdddec615fac7d9190f7f7 406 Pfam PF02601 Exonuclease VII, large subunit 327 398 2.6E-10 T 17-03-2017 IPR020579 Exonuclease VII, large subunit, C-terminal GO:0008855 SHXM_RS33665 8920e2f018bdddec615fac7d9190f7f7 406 Pfam PF02601 Exonuclease VII, large subunit 129 350 1.1E-60 T 17-03-2017 IPR020579 Exonuclease VII, large subunit, C-terminal GO:0008855 SHXM_RS33665 8920e2f018bdddec615fac7d9190f7f7 406 TIGRFAM TIGR00237 xseA: exodeoxyribonuclease VII, large subunit 13 400 4.4E-121 T 17-03-2017 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS33665 8920e2f018bdddec615fac7d9190f7f7 406 Pfam PF13742 OB-fold nucleic acid binding domain 12 105 6.9E-18 T 17-03-2017 IPR025824 OB-fold nucleic acid binding domain GO:0003676 SHXM_RS33665 8920e2f018bdddec615fac7d9190f7f7 406 Hamap MF_00378 Exodeoxyribonuclease 7 large subunit [xseA]. 5 401 25.671 T 17-03-2017 IPR003753 Exonuclease VII, large subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 SUPERFAMILY SSF88659 184 257 1.31E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 PRINTS PR00046 Major sigma-70 factor signature 64 77 9.2E-5 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 PRINTS PR00046 Major sigma-70 factor signature 210 222 9.2E-5 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 PRINTS PR00046 Major sigma-70 factor signature 227 242 9.2E-5 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 37 256 4.0E-30 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 Pfam PF04545 Sigma-70, region 4 207 255 2.5E-13 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 SUPERFAMILY SSF88946 33 110 3.14E-21 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 Pfam PF04539 Sigma-70 region 3 122 191 2.0E-7 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 Gene3D G3DSA:1.10.601.10 33 106 4.2E-12 T 17-03-2017 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 Gene3D G3DSA:1.10.10.10 199 257 1.6E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 SUPERFAMILY SSF88659 113 188 1.73E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 Gene3D G3DSA:1.10.10.10 109 163 7.3E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08280 73c8d31aa514cd0a5f54db52149041d7 261 Pfam PF04542 Sigma-70 region 2 44 108 9.7E-15 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 687 844 2.0E-28 T 17-03-2017 SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 Gene3D G3DSA:1.50.10.10 203 340 1.0E-5 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 60 576 8.9E-157 T 17-03-2017 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 SUPERFAMILY SSF49899 639 848 5.68E-37 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 Gene3D G3DSA:2.60.120.200 674 848 1.7E-29 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 SUPERFAMILY SSF48208 116 411 2.21E-13 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS46150 4e93cbce9afc010c9d8e1091b24c4ca7 849 SMART SM00560 704 841 0.0021 T 17-03-2017 IPR006558 LamG-like jellyroll fold SHXM_RS20560 4a5cf1e3eb260ccd2c5138bab0987c3d 318 Pfam PF00005 ABC transporter 29 165 1.7E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS20560 4a5cf1e3eb260ccd2c5138bab0987c3d 318 SMART SM00382 38 216 1.0E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20560 4a5cf1e3eb260ccd2c5138bab0987c3d 318 Gene3D G3DSA:3.40.50.300 11 228 1.7E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20560 4a5cf1e3eb260ccd2c5138bab0987c3d 318 SUPERFAMILY SSF52540 13 228 4.83E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20560 4a5cf1e3eb260ccd2c5138bab0987c3d 318 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS39450 ea352b9575ed2c93db5e8a484177a188 122 SUPERFAMILY SSF57716 87 120 4.28E-6 T 17-03-2017 SHXM_RS39450 ea352b9575ed2c93db5e8a484177a188 122 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 85 119 5.7E-7 T 17-03-2017 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 Pfam PF00005 ABC transporter 402 548 1.8E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 SUPERFAMILY SSF90123 47 368 3.79E-68 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 Gene3D G3DSA:1.20.1560.10 47 365 8.6E-80 T 17-03-2017 SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 Pfam PF00664 ABC transporter transmembrane region 59 326 1.3E-32 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 SMART SM00382 408 594 1.2E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 ProSitePatterns PS00211 ABC transporters family signature. 520 534 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 SUPERFAMILY SSF52540 378 617 2.71E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35840 2c0ed382486b8e044002f3fa26f6c621 623 Gene3D G3DSA:3.40.50.300 383 611 5.8E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47785 31b9f943ee63b3001827bee6ba642294 305 SUPERFAMILY SSF48498 100 245 8.89E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47785 31b9f943ee63b3001827bee6ba642294 305 SUPERFAMILY SSF46689 26 91 6.48E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47785 31b9f943ee63b3001827bee6ba642294 305 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 99 243 9.6E-25 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS47785 31b9f943ee63b3001827bee6ba642294 305 Gene3D G3DSA:1.10.357.10 24 249 2.4E-62 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47785 31b9f943ee63b3001827bee6ba642294 305 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 82 7.8E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13770 c4777e4130cc37a88eeb9a51e3b42e00 199 Gene3D G3DSA:1.10.10.60 3 59 1.6E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13770 c4777e4130cc37a88eeb9a51e3b42e00 199 SUPERFAMILY SSF46689 11 76 4.67E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13770 c4777e4130cc37a88eeb9a51e3b42e00 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 63 3.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13770 c4777e4130cc37a88eeb9a51e3b42e00 199 SUPERFAMILY SSF48498 83 195 2.02E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS13770 c4777e4130cc37a88eeb9a51e3b42e00 199 Gene3D G3DSA:1.10.357.10 60 192 1.1E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 ProSitePatterns PS00622 LuxR-type HTH domain signature. 887 914 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 Gene3D G3DSA:3.40.50.300 12 169 7.2E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 SUPERFAMILY SSF48452 688 764 1.76E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 SUPERFAMILY SSF48452 794 830 1.76E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 SMART SM00421 870 927 5.4E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 Pfam PF00196 Bacterial regulatory proteins, luxR family 872 923 1.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 873 887 1.3E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 903 915 1.3E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 887 903 1.3E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 Gene3D G3DSA:1.25.40.10 731 834 9.3E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 Gene3D G3DSA:1.25.40.10 539 714 3.5E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 Gene3D G3DSA:1.10.10.10 866 926 2.3E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 SUPERFAMILY SSF46894 864 928 1.29E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 SUPERFAMILY SSF52540 4 235 5.8E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22210 826a7acccedd7fef31f259f6e50e2ff1 936 Pfam PF13191 AAA ATPase domain 12 164 6.3E-17 T 17-03-2017 SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 SUPERFAMILY SSF50952 400 479 9.15E-24 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 SUPERFAMILY SSF50952 51 365 9.15E-24 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 Pfam PF07995 Glucose / Sorbosone dehydrogenase 65 474 3.2E-35 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 Gene3D G3DSA:2.120.10.30 42 502 6.4E-102 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 SUPERFAMILY SSF49299 499 585 2.09E-24 T 17-03-2017 IPR000601 PKD domain SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 SMART SM00089 502 585 7.0E-23 T 17-03-2017 IPR022409 PKD/Chitinase domain SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 Pfam PF03422 Carbohydrate binding module (family 6) 697 821 7.7E-30 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 SUPERFAMILY SSF49785 691 821 1.32E-26 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 SMART SM00606 689 822 4.9E-40 T 17-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 Gene3D G3DSA:2.60.120.260 689 821 5.5E-37 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 Gene3D G3DSA:2.60.40.670 503 585 2.9E-24 T 17-03-2017 IPR000601 PKD domain SHXM_RS42395 34b4b51c6262aba810e6de636e274ecb 823 Pfam PF00801 PKD domain 523 572 4.9E-14 T 17-03-2017 IPR000601 PKD domain SHXM_RS11185 7a5c78df5083be4b2b2db5e6e1ebcfbf 276 Gene3D G3DSA:1.10.3720.10 65 265 8.0E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11185 7a5c78df5083be4b2b2db5e6e1ebcfbf 276 SUPERFAMILY SSF161098 69 255 1.96E-32 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11185 7a5c78df5083be4b2b2db5e6e1ebcfbf 276 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 94 264 2.1E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 SUPERFAMILY SSF54292 211 317 3.54E-25 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 Gene3D G3DSA:2.40.30.10 10 106 5.5E-30 T 17-03-2017 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 45 57 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 57 71 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 191 199 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 141 150 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 81 95 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 116 135 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 PRINTS PR00409 Phthalate dioxygenase reductase family signature 35 45 3.2E-27 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 Pfam PF00175 Oxidoreductase NAD-binding domain 117 205 7.2E-6 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 SUPERFAMILY SSF52343 103 228 7.99E-28 T 17-03-2017 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 Gene3D G3DSA:3.10.20.30 217 317 1.1E-26 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 Gene3D G3DSA:3.40.50.80 111 216 3.3E-24 T 17-03-2017 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 SUPERFAMILY SSF63380 10 105 1.41E-24 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 268 276 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS23525 684ba3131520183db35d33c2ff348e6e 319 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 238 309 1.2E-11 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 Gene3D G3DSA:3.40.50.1820 386 506 1.7E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 Gene3D G3DSA:3.40.50.1820 204 330 1.7E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 Gene3D G3DSA:3.40.50.1820 72 160 1.7E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 Pfam PF00561 alpha/beta hydrolase fold 108 486 2.4E-31 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 SUPERFAMILY SSF53474 90 161 5.19E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 SUPERFAMILY SSF53474 206 260 5.19E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 SUPERFAMILY SSF53474 362 370 5.19E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08445 0f7354ed3d9e57684d941a699b90a681 547 SUPERFAMILY SSF53474 407 506 5.19E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 26 134 5.6E-20 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 SUPERFAMILY SSF51604 122 368 2.23E-50 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 SUPERFAMILY SSF54826 3 135 4.61E-27 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 109 134 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 SMART SM00922 152 246 3.7E-9 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 Pfam PF13378 Enolase C-terminal domain-like 157 364 5.1E-40 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 Gene3D G3DSA:3.30.390.10 2 132 2.1E-39 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS03905 3a31844c9e0bfb700d83471c5c2a8800 376 Gene3D G3DSA:3.20.20.120 133 360 5.0E-54 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS05100 009b43af6822bce2ed17556b3d5127c3 168 SUPERFAMILY SSF53155 3 87 7.06E-12 T 17-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS05100 009b43af6822bce2ed17556b3d5127c3 168 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 83 163 5.3E-31 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS05100 009b43af6822bce2ed17556b3d5127c3 168 SUPERFAMILY SSF46767 81 164 4.84E-30 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS05100 009b43af6822bce2ed17556b3d5127c3 168 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 82 162 4.3E-33 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS05100 009b43af6822bce2ed17556b3d5127c3 168 Gene3D G3DSA:1.10.10.10 81 164 9.7E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 SUPERFAMILY SSF55205 74 506 9.81E-95 T 17-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 SMART SM00530 12 67 1.2E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 Gene3D G3DSA:3.65.10.10 293 505 2.1E-41 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 Pfam PF01381 Helix-turn-helix 13 63 3.2E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 Gene3D G3DSA:1.10.260.40 3 66 2.0E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 Gene3D G3DSA:3.65.10.10 92 292 3.9E-38 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 80 496 4.4E-43 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS38100 44f1414e2a024c0063752fcc2ccaef2a 509 SUPERFAMILY SSF47413 4 65 7.78E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 SUPERFAMILY SSF52172 21 202 6.04E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 Pfam PF00072 Response regulator receiver domain 24 135 1.7E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 186 1.7E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 202 214 1.7E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 202 1.7E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 SMART SM00448 22 135 5.1E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 ProSitePatterns PS00622 LuxR-type HTH domain signature. 186 213 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 Gene3D G3DSA:3.40.50.2300 20 170 5.7E-39 T 17-03-2017 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 SMART SM00421 169 226 6.7E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 Pfam PF00196 Bacterial regulatory proteins, luxR family 172 226 5.1E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS46045 3a563a9777c99d16cdea5d1afccc4d20 232 Gene3D G3DSA:1.10.10.10 171 231 8.2E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 ProSitePatterns PS00641 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. 51 68 - T 17-03-2017 IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site GO:0008137|GO:0016020|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 242 289 5.8E-5 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 ProSitePatterns PS00642 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. 120 132 - T 17-03-2017 IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site GO:0008137|GO:0016020|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:2.20.25.90 242 290 5.1E-11 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 ProSitePatterns PS00643 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. 168 178 - T 17-03-2017 IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site GO:0008137|GO:0016020|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 SUPERFAMILY SSF53706 229 713 6.28E-85 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Pfam PF01568 Molydopterin dinucleotide binding domain 746 803 7.6E-6 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 SUPERFAMILY SSF50692 720 802 1.55E-6 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 SMART SM00929 105 145 3.1E-19 T 17-03-2017 IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:3.40.50.740 295 364 3.0E-46 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:3.40.50.740 561 698 3.0E-46 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:3.40.50.740 405 442 3.0E-46 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:3.30.70.20 159 225 6.9E-4 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 TIGRFAM TIGR01973 NuoG: NADH dehydrogenase (quinone), G subunit 24 675 9.9E-190 T 17-03-2017 IPR010228 NADH:ubiquinone oxidoreductase, subunit G GO:0016651|GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:2.40.40.20 746 804 1.0E-4 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 SUPERFAMILY SSF54292 22 94 3.28E-19 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Pfam PF10588 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region 105 143 4.8E-16 T 17-03-2017 IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 21 95 1.8E-18 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 SMART SM00926 238 292 1.5E-7 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 SUPERFAMILY SSF54862 98 233 5.86E-31 T 17-03-2017 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Pfam PF00384 Molybdopterin oxidoreductase 295 441 2.2E-10 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Pfam PF00384 Molybdopterin oxidoreductase 478 660 7.1E-10 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30785 a783fcc8a3b8ebb1c695d39148eb7e9c 829 Gene3D G3DSA:3.10.20.30 22 76 1.1E-5 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00501 AMP-binding enzyme 470 869 8.0E-91 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00501 AMP-binding enzyme 1527 1933 1.2E-105 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.40.50.980 1521 1685 5.0E-52 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.30.300.30 863 963 6.6E-39 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1000 1015 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF56801 429 989 2.88E-152 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 1549 1957 4.9E-140 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 491 892 6.1E-129 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00975 Thioesterase domain 2130 2356 7.3E-25 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF13745 HxxPF-repeated domain 1378 1473 2.3E-31 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF52777 195 458 7.23E-58 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 ProSitePatterns PS00455 Putative AMP-binding domain signature. 619 630 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2066 2081 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SMART SM00823 Phosphopantetheine attachment site 976 1045 8.9E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SMART SM00823 Phosphopantetheine attachment site 2042 2111 1.9E-7 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF13193 AMP-binding enzyme C-terminal domain 877 952 1.6E-13 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF13193 AMP-binding enzyme C-terminal domain 1941 2017 9.9E-15 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.40.50.1820 2305 2371 3.3E-42 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.40.50.1820 2116 2233 3.3E-42 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:1.10.1200.10 964 1044 2.2E-27 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:1.10.1200.10 2047 2110 2.1E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF56801 1486 2055 4.58E-174 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.30.300.30 1928 2046 1.2E-43 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 ProSitePatterns PS00455 Putative AMP-binding domain signature. 1677 1688 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00668 Condensation domain 1059 1356 1.6E-67 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00668 Condensation domain 12 309 2.6E-64 T 17-03-2017 IPR001242 Condensation domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00550 Phosphopantetheine attachment site 2044 2107 8.1E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Pfam PF00550 Phosphopantetheine attachment site 979 1041 6.0E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.40.50.980 464 623 1.5E-48 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:2.30.38.10 1845 1923 1.7E-27 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:2.30.38.10 782 859 7.5E-25 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.40.50.980 624 781 1.2E-30 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 Gene3D G3DSA:3.40.50.980 1686 1844 5.6E-49 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF52777 9 210 7.89E-44 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF47336 969 1041 3.66E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF53474 2112 2371 2.48E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF52777 1062 1232 1.22E-50 T 17-03-2017 SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF47336 2035 2108 2.36E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37810 b7cf65340f195dd266b9df54f4263366 2375 SUPERFAMILY SSF52777 1245 1515 1.89E-63 T 17-03-2017 SHXM_RS30100 782fef32f77728abbd0c629ed518f510 228 Pfam PF11209 Protein of unknown function (DUF2993) 20 219 2.4E-32 T 17-03-2017 IPR021373 Protein of unknown function DUF2993 SHXM_RS29555 5dc4fdcbba7437f18feaaf7cf34ecca4 66 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 12 58 1.2E-9 T 17-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 SHXM_RS29555 5dc4fdcbba7437f18feaaf7cf34ecca4 66 Pfam PF12728 Helix-turn-helix domain 12 60 4.2E-12 T 17-03-2017 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 197 262 1.3E-6 T 17-03-2017 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 17 97 4.6E-8 T 17-03-2017 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 SUPERFAMILY SSF69318 13 424 1.83E-54 T 17-03-2017 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Pfam PF01839 FG-GAP repeat 399 433 3.6E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Pfam PF01839 FG-GAP repeat 325 363 7.3E-9 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 SMART SM00191 395 449 0.0023 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 SMART SM00191 239 309 64.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 SMART SM00191 6 63 28.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 SMART SM00191 75 132 7.0E-5 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 SMART SM00191 321 379 7.7E-7 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Gene3D G3DSA:2.130.10.130 14 166 1.5E-17 T 17-03-2017 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Gene3D G3DSA:2.130.10.130 381 451 1.0E-10 T 17-03-2017 SHXM_RS48690 08d0ac8fc208c26133c6e08f25296535 467 Gene3D G3DSA:2.130.10.130 193 371 2.4E-23 T 17-03-2017 SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 54 205 2.2E-23 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 SUPERFAMILY SSF88946 54 130 1.88E-10 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 Pfam PF08281 Sigma-70, region 4 150 202 8.7E-17 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 Gene3D G3DSA:1.10.1740.10 53 124 4.8E-10 T 17-03-2017 SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 Pfam PF04542 Sigma-70 region 2 57 123 2.3E-6 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 Gene3D G3DSA:1.10.10.10 147 207 6.6E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22355 2047fe401c7ec4cd44550287552907ca 210 SUPERFAMILY SSF88659 138 207 4.49E-17 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 SUPERFAMILY SSF52540 2 255 3.63E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 SMART SM00382 31 234 3.3E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 234 304 4.6E-19 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 ProSitePatterns PS00211 ABC transporters family signature. 152 166 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 236 299 2.3E-16 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 Gene3D G3DSA:3.40.50.300 2 258 1.3E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13705 36363775c4dcbc7ada04b3e08dac6648 343 Pfam PF00005 ABC transporter 23 180 4.6E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 Pfam PF01593 Flavin containing amine oxidoreductase 18 490 1.9E-55 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 Gene3D G3DSA:3.50.50.60 218 301 3.5E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 Gene3D G3DSA:3.50.50.60 125 139 3.5E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 Gene3D G3DSA:3.50.50.60 446 492 3.5E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 Gene3D G3DSA:3.50.50.60 10 64 3.5E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 ProSitePatterns PS00982 Bacterial-type phytoene dehydrogenase signature. 462 482 - T 17-03-2017 IPR008150 Phytoene dehydrogenase, bacterial-type, conserved site SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 SUPERFAMILY SSF51905 10 319 6.48E-63 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 SUPERFAMILY SSF51905 452 491 6.48E-63 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01430 a3dacce18823ca39b23420b2f6a19ccb 523 TIGRFAM TIGR02734 crtI_fam: phytoene desaturase 11 497 1.2E-174 T 17-03-2017 IPR014105 Carotenoid/retinoid oxidoreductase GO:0016117|GO:0055114 SHXM_RS25020 943835366dec0f5faa80014e6eafc341 203 Gene3D G3DSA:1.10.357.10 1 201 1.6E-41 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS25020 943835366dec0f5faa80014e6eafc341 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 57 6.9E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25020 943835366dec0f5faa80014e6eafc341 203 SUPERFAMILY SSF48498 82 201 2.48E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS25020 943835366dec0f5faa80014e6eafc341 203 Pfam PF13977 Bacterial transcriptional repressor 85 198 6.0E-14 T 17-03-2017 SHXM_RS25020 943835366dec0f5faa80014e6eafc341 203 SUPERFAMILY SSF46689 2 81 9.23E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Pfam PF00550 Phosphopantetheine attachment site 88 154 2.2E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SMART SM00825 Beta-ketoacyl synthase 180 599 1.6E-217 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SUPERFAMILY SSF47336 80 193 1.57E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Gene3D G3DSA:3.30.70.250 842 873 5.5E-4 T 17-03-2017 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SUPERFAMILY SSF52151 700 825 6.8E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SUPERFAMILY SSF52151 880 981 6.8E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Gene3D G3DSA:1.10.1200.10 84 158 4.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 549 666 1.3E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Pfam PF00698 Acyl transferase domain 701 1003 5.0E-81 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Gene3D G3DSA:3.40.47.10 434 598 7.7E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 178 421 1.3E-84 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05365 799d99766a953aee074127988060d59c 1005 ProSitePatterns PS00012 Phosphopantetheine attachment site. 113 128 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 429 546 5.7E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Gene3D G3DSA:3.40.47.10 175 433 4.7E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SMART SM01294 87 154 0.0012 T 17-03-2017 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 334 350 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Gene3D G3DSA:3.40.366.10 879 1001 9.0E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 Gene3D G3DSA:3.40.366.10 690 820 9.0E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SUPERFAMILY SSF55048 823 875 1.83E-7 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SMART SM00823 Phosphopantetheine attachment site 86 158 2.8E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SUPERFAMILY SSF53901 175 543 8.2E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05365 799d99766a953aee074127988060d59c 1005 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 703 988 1.7E-113 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 Gene3D G3DSA:1.10.580.10 13 221 5.8E-47 T 17-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 Pfam PF00285 Citrate synthase, C-terminal domain 7 343 1.5E-85 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 Gene3D G3DSA:1.10.230.10 222 306 5.6E-25 T 17-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 SUPERFAMILY SSF48256 3 354 9.03E-96 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 ProSitePatterns PS00480 Citrate synthase signature. 242 254 - T 17-03-2017 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 Reactome: R-HSA-1268020|Reactome: R-HSA-71403 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 PRINTS PR00143 Citrate synthase signature 235 255 3.4E-26 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 PRINTS PR00143 Citrate synthase signature 294 310 3.4E-26 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 PRINTS PR00143 Citrate synthase signature 160 175 3.4E-26 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 PRINTS PR00143 Citrate synthase signature 314 328 3.4E-26 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25580 936fdc404b326a43c154a0ba1a842655 366 PRINTS PR00143 Citrate synthase signature 182 210 3.4E-26 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS46495 d4cd74026f40c1525f1a17499ecc33e5 284 SUPERFAMILY SSF52540 13 234 9.37E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46495 d4cd74026f40c1525f1a17499ecc33e5 284 Pfam PF00005 ABC transporter 29 171 9.3E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46495 d4cd74026f40c1525f1a17499ecc33e5 284 SMART SM00382 37 229 1.2E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS46495 d4cd74026f40c1525f1a17499ecc33e5 284 Gene3D G3DSA:3.40.50.300 5 235 1.4E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Gene3D G3DSA:3.30.559.10 331 570 1.1E-76 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 SUPERFAMILY SSF51230 126 219 2.75E-26 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Gene3D G3DSA:4.10.320.10 275 320 9.0E-19 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 SUPERFAMILY SSF52777 330 570 4.23E-77 T 17-03-2017 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 27 56 - T 17-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 TIGRFAM TIGR02927 SucB_Actino: 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase 1 579 1.1E-231 T 17-03-2017 IPR014276 2-oxoglutarate dehydrogenase, E2 component KEGG: 00010+2.3.1.12|KEGG: 00020+2.3.1.12|KEGG: 00620+2.3.1.12 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 344 570 1.8E-71 T 17-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Gene3D G3DSA:2.40.50.100 126 218 7.5E-29 T 17-03-2017 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Gene3D G3DSA:2.40.50.100 1 96 4.6E-30 T 17-03-2017 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Pfam PF02817 e3 binding domain 277 309 1.7E-14 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Pfam PF00364 Biotin-requiring enzyme 127 199 9.3E-20 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 Pfam PF00364 Biotin-requiring enzyme 5 76 1.9E-21 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 SUPERFAMILY SSF51230 1 96 2.22E-27 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 150 179 - T 17-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 SHXM_RS19015 317b990ef3c43140a576a73f0502d771 579 SUPERFAMILY SSF47005 270 313 5.1E-12 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 SUPERFAMILY SSF90123 778 1095 3.4E-43 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 TIGRFAM TIGR02868 CydC: thiol reductant ABC exporter, CydC subunit 779 1306 9.3E-201 T 17-03-2017 IPR014223 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC GO:0006810|GO:0016021|GO:0042626 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 ProSitePatterns PS00211 ABC transporters family signature. 1248 1262 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 TIGRFAM TIGR02857 CydD: thiol reductant ABC exporter, CydD subunit 16 543 4.2E-216 T 17-03-2017 IPR014216 ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD GO:0005524|GO:0016020|GO:0042883 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 SUPERFAMILY SSF90123 2 319 5.36E-60 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 SUPERFAMILY SSF52540 1107 1344 2.93E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 SMART SM00382 1136 1322 6.9E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 SMART SM00382 361 547 8.7E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Pfam PF00005 ABC transporter 1128 1275 3.5E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Pfam PF00005 ABC transporter 354 501 1.8E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Gene3D G3DSA:3.40.50.300 334 543 1.3E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 ProSitePatterns PS00211 ABC transporters family signature. 473 487 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Gene3D G3DSA:3.40.50.300 1112 1348 1.0E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Pfam PF00664 ABC transporter transmembrane region 22 272 6.9E-32 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Pfam PF00664 ABC transporter transmembrane region 794 1042 1.3E-6 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 SUPERFAMILY SSF52540 331 544 1.52E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Gene3D G3DSA:1.20.1560.10 6 326 1.0E-51 T 17-03-2017 SHXM_RS27790 204fe0882abcde1ff24b68cd494b0145 1382 Gene3D G3DSA:1.20.1560.10 779 1094 4.2E-35 T 17-03-2017 SHXM_RS11310 71b77aa5581f5e46c4fb72a8de9587f7 206 SUPERFAMILY SSF53335 3 206 6.91E-42 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11310 71b77aa5581f5e46c4fb72a8de9587f7 206 Pfam PF13649 Methyltransferase domain 48 139 1.0E-21 T 17-03-2017 SHXM_RS11310 71b77aa5581f5e46c4fb72a8de9587f7 206 Gene3D G3DSA:3.40.50.150 7 186 7.8E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS31040 5831c807b6c18f70667f3be4d9875ed4 54 Pfam PF00471 Ribosomal protein L33 9 54 2.2E-23 T 17-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31040 5831c807b6c18f70667f3be4d9875ed4 54 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 6 54 19.785 T 17-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31040 5831c807b6c18f70667f3be4d9875ed4 54 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 2 54 1.8E-22 T 17-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31040 5831c807b6c18f70667f3be4d9875ed4 54 ProSitePatterns PS00582 Ribosomal protein L33 signature. 22 41 - T 17-03-2017 IPR018264 Ribosomal protein L33, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31040 5831c807b6c18f70667f3be4d9875ed4 54 SUPERFAMILY SSF57829 4 54 7.32E-20 T 17-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 Gene3D G3DSA:3.40.50.1820 28 314 6.3E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 SUPERFAMILY SSF53474 28 315 1.05E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00111 Alpha/beta hydrolase fold signature 122 135 4.9E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00111 Alpha/beta hydrolase fold signature 136 149 4.9E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00111 Alpha/beta hydrolase fold signature 77 92 4.9E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00412 Epoxide hydrolase signature 136 149 5.2E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00412 Epoxide hydrolase signature 257 273 5.2E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00412 Epoxide hydrolase signature 290 312 5.2E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00412 Epoxide hydrolase signature 58 76 5.2E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 PRINTS PR00412 Epoxide hydrolase signature 122 135 5.2E-5 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS34220 6c24d65c56dec9fe56dcb6e0eedf84ef 344 Pfam PF00561 alpha/beta hydrolase fold 55 300 3.6E-25 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS10370 232b567e414558c23beb58f0340e9292 393 Gene3D G3DSA:1.10.260.40 8 80 7.8E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10370 232b567e414558c23beb58f0340e9292 393 SUPERFAMILY SSF47413 6 69 2.52E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10370 232b567e414558c23beb58f0340e9292 393 SMART SM00530 10 65 4.5E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS10370 232b567e414558c23beb58f0340e9292 393 Pfam PF13560 Helix-turn-helix domain 8 62 6.5E-10 T 17-03-2017 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 SUPERFAMILY SSF117125 664 742 6.54E-18 T 17-03-2017 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 SUPERFAMILY SSF51011 584 662 5.47E-19 T 17-03-2017 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 Gene3D G3DSA:3.20.20.70 383 462 7.4E-11 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 Gene3D G3DSA:3.20.20.70 273 348 7.4E-11 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 Pfam PF01055 Glycosyl hydrolases family 31 238 667 1.2E-121 T 17-03-2017 IPR000322 Glycoside hydrolase family 31 GO:0004553|GO:0005975 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 SUPERFAMILY SSF74650 1 245 3.14E-58 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 Pfam PF13802 Galactose mutarotase-like 159 216 5.8E-16 T 17-03-2017 IPR025887 Glycoside hydrolase family 31, N-terminal domain SHXM_RS23790 0f6fce5f8deaffd3d7f3583b557ec2c3 756 SUPERFAMILY SSF51445 246 582 7.27E-96 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS09795 5dfe7de3a2d0d50f237afa94218bbecb 468 Gene3D G3DSA:2.130.10.10 313 440 6.8E-16 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS09795 5dfe7de3a2d0d50f237afa94218bbecb 468 SUPERFAMILY SSF82171 197 443 4.32E-23 T 17-03-2017 SHXM_RS09795 5dfe7de3a2d0d50f237afa94218bbecb 468 Gene3D G3DSA:2.130.10.10 194 250 1.1E-6 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 Gene3D G3DSA:3.40.50.1000 12 32 3.2E-40 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 Gene3D G3DSA:3.40.50.1000 104 220 3.2E-40 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 18 29 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 143 159 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 113 126 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 161 181 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 SUPERFAMILY SSF56784 19 210 3.02E-45 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 Pfam PF13419 Haloacid dehalogenase-like hydrolase 21 199 3.0E-26 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS15975 f7273cd29e471d77317dcbaa5a5b11bb 233 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 91 199 3.7E-14 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS08600 add07f0c1c32a0f023cd99e473fcde81 180 SUPERFAMILY SSF52141 14 173 5.23E-46 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS08600 add07f0c1c32a0f023cd99e473fcde81 180 SMART SM00987 15 178 2.6E-9 T 17-03-2017 SHXM_RS08600 add07f0c1c32a0f023cd99e473fcde81 180 SMART SM00986 15 178 2.6E-9 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS08600 add07f0c1c32a0f023cd99e473fcde81 180 Pfam PF03167 Uracil DNA glycosylase superfamily 16 162 2.7E-26 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS08600 add07f0c1c32a0f023cd99e473fcde81 180 Gene3D G3DSA:3.40.470.10 14 176 1.8E-56 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS03000 568f2f5e1ae77d048b4f2d9c88cf585c 288 SUPERFAMILY SSF51658 2 285 1.44E-58 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS03000 568f2f5e1ae77d048b4f2d9c88cf585c 288 Pfam PF01261 Xylose isomerase-like TIM barrel 20 242 1.4E-35 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS03000 568f2f5e1ae77d048b4f2d9c88cf585c 288 Gene3D G3DSA:3.20.20.150 2 282 2.4E-54 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 333 342 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 SUPERFAMILY SSF48264 9 393 1.44E-103 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 Pfam PF00067 Cytochrome P450 177 361 1.7E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 Gene3D G3DSA:1.10.630.10 5 394 7.1E-138 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 129 145 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 310 325 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 182 204 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 146 161 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 264 275 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 331 340 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 83 94 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 340 351 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS43380 742ff013dea748eb0a17ec4eb7d7a394 397 PRINTS PR00359 B-class P450 signature 282 309 4.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 Gene3D G3DSA:3.30.565.10 317 415 2.0E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 351 365 1.7E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 375 393 1.7E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 PRINTS PR00344 Bacterial sensor protein C-terminal signature 399 412 1.7E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 SUPERFAMILY SSF55874 286 412 5.37E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 317 411 4.5E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 SMART SM00387 315 415 5.1E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 PIRSF PIRSF037434 3 419 4.1E-79 T 17-03-2017 IPR017205 Signal transduction histidine kinase, ChrS SHXM_RS07190 b827900cee6efe681eb4d18bb501ebc3 420 Pfam PF07730 Histidine kinase 211 277 2.2E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS00975 299c16b292ef66fa46e3d0f220f8cc4b 230 Gene3D G3DSA:1.10.443.10 70 177 1.6E-6 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS00975 299c16b292ef66fa46e3d0f220f8cc4b 230 Pfam PF00589 Phage integrase family 71 176 3.0E-5 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS00975 299c16b292ef66fa46e3d0f220f8cc4b 230 SUPERFAMILY SSF56349 18 175 9.42E-10 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:1.10.1200.10 3584 3657 2.8E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:1.10.1200.10 1721 1798 5.1E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF51735 3301 3518 1.77E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF00698 Acyl transferase domain 570 887 2.2E-91 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF00698 Acyl transferase domain 2354 2661 5.4E-53 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF55048 695 760 1.03E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 6.8E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2076 2194 2.4E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF51735 1224 1417 3.87E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF52151 568 697 9.42E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF52151 761 860 9.42E-70 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 6.5E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1823 2068 3.7E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF01391 Collagen triple helix repeat (20 copies) 3225 3278 3.1E-7 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF08659 KR domain 1437 1616 3.7E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF08659 KR domain 3302 3481 3.3E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF08990 Erythronolide synthase docking 2 27 5.4E-13 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF53901 31 399 3.61E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF00550 Phosphopantetheine attachment site 3587 3653 1.9E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF00550 Phosphopantetheine attachment site 1726 1792 9.0E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF52151 2533 2639 1.12E-73 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF52151 2351 2471 1.12E-73 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF14765 Polyketide synthase dehydratase 2713 3007 4.3E-64 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF14765 Polyketide synthase dehydratase 939 1218 1.0E-47 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.366.10 569 691 2.5E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.366.10 760 870 2.5E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF51735 1435 1670 1.77E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00825 Beta-ketoacyl synthase 1825 2247 5.8E-224 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00825 Beta-ketoacyl synthase 36 462 2.2E-229 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00826 2713 2877 8.8E-87 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00826 939 1102 4.4E-73 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3612 3627 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.47.10 1825 2080 2.2E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.47.10 36 296 1.6E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1981 1997 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF53901 1820 2191 7.29E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF55048 2476 2540 9.29E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00823 Phosphopantetheine attachment site 3585 3657 3.8E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00823 Phosphopantetheine attachment site 1724 1796 1.3E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1751 1766 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2354 2646 8.7E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 571 869 8.3E-131 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.47.10 2081 2246 1.1E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.47.10 297 462 1.1E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF51735 3015 3214 1.22E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3302 3482 5.9E-56 T 17-03-2017 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1437 1617 8.2E-62 T 17-03-2017 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.366.10 2540 2649 5.2E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.366.10 2348 2471 5.2E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.30.70.250 695 759 1.7E-7 T 17-03-2017 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.30.70.250 2476 2539 1.5E-5 T 17-03-2017 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 532 7.2E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2197 2317 1.7E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF47336 1719 1838 6.41E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM01294 1725 1792 2.0E-5 T 17-03-2017 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SMART SM01294 3586 3653 1.0E-5 T 17-03-2017 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF101173 3 31 7.85E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.50.720 1438 1648 6.1E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 Gene3D G3DSA:3.40.50.720 3301 3484 1.0E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04350 d4322fc28f7f21c88e65fa7b22c19a5e 3658 SUPERFAMILY SSF47336 3582 3657 7.72E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 PIRSF PIRSF000110 2 472 2.2E-136 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 Pfam PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 189 460 1.4E-84 T 17-03-2017 IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 SUPERFAMILY SSF51735 5 190 1.84E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 ProSitePatterns PS00069 Glucose-6-phosphate dehydrogenase active site. 177 183 - T 17-03-2017 IPR019796 Glucose-6-phosphate dehydrogenase, active site GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 TIGRFAM TIGR00871 zwf: glucose-6-phosphate dehydrogenase 6 464 1.1E-137 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 SUPERFAMILY SSF55347 177 464 2.26E-91 T 17-03-2017 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 Hamap MF_00966 Glucose-6-phosphate 1-dehydrogenase [zwf]. 6 474 73.925 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 Gene3D G3DSA:3.30.360.10 187 460 1.7E-93 T 17-03-2017 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 314 340 1.0E-38 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 167 195 1.0E-38 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 219 236 1.0E-38 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 237 253 1.0E-38 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 143 156 1.0E-38 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 Pfam PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 10 187 2.3E-46 T 17-03-2017 IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS13820 ca32f07d5e5061ed547671ba7cc1337d 484 Gene3D G3DSA:3.40.50.720 5 186 1.0E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00097 Anthranilate synthase component II signature 349 362 1.8E-5 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00097 Anthranilate synthase component II signature 230 239 1.8E-5 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00097 Anthranilate synthase component II signature 258 269 1.8E-5 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 Pfam PF00988 Carbamoyl-phosphate synthase small chain, CPSase domain 12 138 1.0E-52 T 17-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 Hamap MF_01209 Carbamoyl-phosphate synthase small chain [carA]. 10 378 46.1 T 17-03-2017 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 Gene3D G3DSA:3.40.50.880 160 377 1.8E-61 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 SUPERFAMILY SSF52317 160 377 9.94E-51 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 SUPERFAMILY SSF52021 11 146 3.92E-56 T 17-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 227 241 1.1E-29 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 258 274 1.1E-29 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 300 311 1.1E-29 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 275 292 1.1E-29 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 188 202 1.1E-29 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 TIGRFAM TIGR01368 CPSaseIIsmall: carbamoyl-phosphate synthase, small subunit 12 375 5.0E-135 T 17-03-2017 IPR006274 Carbamoyl-phosphate synthase, small subunit GO:0004088|GO:0006207|GO:0006541 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00096 Glutamine amidotransferase superfamily signature 349 362 8.0E-11 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00096 Glutamine amidotransferase superfamily signature 258 269 8.0E-11 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 PRINTS PR00096 Glutamine amidotransferase superfamily signature 230 239 8.0E-11 T 17-03-2017 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 SMART SM01097 10 140 5.1E-88 T 17-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 Gene3D G3DSA:3.50.30.20 11 149 1.4E-59 T 17-03-2017 IPR002474 Carbamoyl-phosphate synthase, small subunit N-terminal domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12360 c0e9b88dd23910d0ea60b443e3d2e525 379 Pfam PF00117 Glutamine amidotransferase class-I 191 372 1.4E-37 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS14390 33ef2e1abb9fd0137d56281e7cc101ef 806 Gene3D G3DSA:3.40.720.10 137 322 1.0E-11 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS14390 33ef2e1abb9fd0137d56281e7cc101ef 806 Gene3D G3DSA:3.40.720.10 365 447 1.0E-11 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS14390 33ef2e1abb9fd0137d56281e7cc101ef 806 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 362 465 7.7E-8 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS14390 33ef2e1abb9fd0137d56281e7cc101ef 806 Pfam PF04020 Mycobacterial 4 TMS phage holin, superfamily IV 15 127 3.3E-11 T 17-03-2017 IPR007165 Mycobacterial 4 TMS phage holin, superfamily IV SHXM_RS14390 33ef2e1abb9fd0137d56281e7cc101ef 806 SUPERFAMILY SSF53649 165 250 5.89E-11 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS14390 33ef2e1abb9fd0137d56281e7cc101ef 806 SUPERFAMILY SSF53649 302 448 5.89E-11 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 Gene3D G3DSA:2.30.38.10 370 440 3.1E-10 T 17-03-2017 SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 Gene3D G3DSA:3.40.50.980 59 211 1.3E-26 T 17-03-2017 SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 SUPERFAMILY SSF56801 32 551 2.09E-122 T 17-03-2017 SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 Gene3D G3DSA:3.30.300.30 442 547 4.5E-29 T 17-03-2017 SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 Pfam PF13193 AMP-binding enzyme C-terminal domain 456 534 4.3E-23 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 ProSitePatterns PS00455 Putative AMP-binding domain signature. 206 217 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 Gene3D G3DSA:3.40.50.980 212 359 1.1E-24 T 17-03-2017 SHXM_RS42035 4bddabf99630cffda0f192d065d9f07d 560 Pfam PF00501 AMP-binding enzyme 59 447 2.9E-69 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS35875 325622779f7cceb982a1576664941462 76 ProSitePatterns PS00018 EF-hand calcium-binding domain. 52 64 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS35875 325622779f7cceb982a1576664941462 76 SUPERFAMILY SSF47473 4 66 3.91E-17 T 17-03-2017 IPR011992 EF-hand domain pair SHXM_RS35875 325622779f7cceb982a1576664941462 76 ProSitePatterns PS00018 EF-hand calcium-binding domain. 15 27 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS35875 325622779f7cceb982a1576664941462 76 Gene3D G3DSA:1.10.238.10 4 70 5.0E-18 T 17-03-2017 IPR011992 EF-hand domain pair SHXM_RS35875 325622779f7cceb982a1576664941462 76 SMART SM00054 6 34 2.4E-4 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS35875 325622779f7cceb982a1576664941462 76 SMART SM00054 43 71 9.3 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS35875 325622779f7cceb982a1576664941462 76 Pfam PF13499 EF-hand domain pair 6 64 8.5E-11 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Gene3D G3DSA:3.30.300.30 319 404 1.9E-10 T 17-03-2017 SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 SUPERFAMILY SSF56801 19 409 5.89E-65 T 17-03-2017 SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Gene3D G3DSA:3.40.50.150 595 679 8.2E-5 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Gene3D G3DSA:1.10.10.10 417 482 3.5E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Pfam PF00501 AMP-binding enzyme 19 288 1.1E-28 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 SUPERFAMILY SSF53335 562 682 3.84E-9 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 SUPERFAMILY SSF46785 416 480 1.44E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Pfam PF13193 AMP-binding enzyme C-terminal domain 330 404 2.3E-8 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Gene3D G3DSA:3.40.50.980 99 256 3.0E-19 T 17-03-2017 SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 Gene3D G3DSA:2.30.38.10 257 289 1.1E-5 T 17-03-2017 SHXM_RS12035 0b4bdfdce4e3bb66fe6330e585e8cd77 695 ProSitePatterns PS00455 Putative AMP-binding domain signature. 99 110 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 SUPERFAMILY SSF48452 1051 1091 2.37E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 SUPERFAMILY SSF48452 1130 1246 2.37E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 Gene3D G3DSA:1.25.40.10 1032 1090 4.1E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 Gene3D G3DSA:1.25.40.10 1177 1421 4.1E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 Pfam PF13424 Tetratricopeptide repeat 1352 1424 3.8E-9 T 17-03-2017 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 Pfam PF13424 Tetratricopeptide repeat 1269 1337 1.5E-8 T 17-03-2017 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 SUPERFAMILY SSF48452 1226 1336 4.17E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 SUPERFAMILY SSF48452 1303 1422 9.86E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 SUPERFAMILY SSF52540 623 878 1.91E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07690 8b0c6d67ad0ef80db8acab611ff6d331 1452 Pfam PF00931 NB-ARC domain 638 835 4.7E-11 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 Pfam PF03572 Peptidase family S41 226 379 7.5E-40 T 17-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 Pfam PF00595 PDZ domain (Also known as DHR or GLGF) 113 176 5.5E-10 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 SMART SM00228 113 191 6.6E-14 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 SUPERFAMILY SSF50156 101 209 3.81E-18 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 Gene3D G3DSA:2.30.42.10 116 201 9.4E-20 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 Gene3D G3DSA:3.90.226.10 202 383 2.7E-46 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 SUPERFAMILY SSF52096 81 134 2.65E-45 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 SUPERFAMILY SSF52096 216 384 2.65E-45 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS23840 444d7ec5c70b6ccac96fd025d9c419af 403 SMART SM00245 191 381 9.2E-43 T 17-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 SHXM_RS14445 4ca1d03e37944f68d6502c994ae93544 260 SUPERFAMILY SSF52540 8 226 2.66E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14445 4ca1d03e37944f68d6502c994ae93544 260 Gene3D G3DSA:3.40.50.300 7 223 2.2E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14445 4ca1d03e37944f68d6502c994ae93544 260 SMART SM00382 34 223 2.7E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14445 4ca1d03e37944f68d6502c994ae93544 260 Pfam PF00005 ABC transporter 25 175 3.1E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS03105 1024ee0010e310378b8a0532ffacacc8 212 Gene3D G3DSA:1.10.10.10 138 203 1.7E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03105 1024ee0010e310378b8a0532ffacacc8 212 SUPERFAMILY SSF46785 130 204 5.1E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 SMART SM00062 64 297 2.0E-23 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 Gene3D G3DSA:3.40.190.10 253 293 4.8E-17 T 17-03-2017 SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 Gene3D G3DSA:3.40.190.10 61 143 4.8E-17 T 17-03-2017 SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 Gene3D G3DSA:3.40.190.10 144 248 2.3E-14 T 17-03-2017 SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 70 294 2.3E-38 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 SUPERFAMILY SSF53850 1 22 1.64E-41 T 17-03-2017 SHXM_RS26200 887e158f7abf6da7b0e3b91b730ffc2b 311 SUPERFAMILY SSF53850 54 295 1.64E-41 T 17-03-2017 SHXM_RS17640 f910e61d722df62490222ca003ca0538 444 SUPERFAMILY SSF53850 24 435 1.28E-75 T 17-03-2017 SHXM_RS17640 f910e61d722df62490222ca003ca0538 444 Gene3D G3DSA:3.40.190.10 41 176 2.4E-20 T 17-03-2017 SHXM_RS17640 f910e61d722df62490222ca003ca0538 444 Gene3D G3DSA:3.40.190.10 177 367 1.7E-40 T 17-03-2017 SHXM_RS17640 f910e61d722df62490222ca003ca0538 444 Pfam PF01547 Bacterial extracellular solute-binding protein 54 347 7.4E-42 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 Pfam PF08245 Mur ligase middle domain 114 317 4.6E-46 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 Gene3D G3DSA:3.40.1390.10 25 103 8.0E-12 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 SUPERFAMILY SSF63418 3 105 2.49E-13 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 SUPERFAMILY SSF53623 105 336 5.76E-61 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 TIGRFAM TIGR01085 murE: UDP-N-acetylmuramyl-tripeptide synthetase 29 489 4.2E-132 T 17-03-2017 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 ProSitePatterns PS01011 Folylpolyglutamate synthase signature 1. 112 136 - T 17-03-2017 IPR018109 Folylpolyglutamate synthetase, conserved site GO:0004326|GO:0005524|GO:0009396 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 SUPERFAMILY SSF53244 337 489 1.24E-44 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 Pfam PF02875 Mur ligase family, glutamate ligase domain 337 422 4.2E-22 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 Gene3D G3DSA:3.90.190.20 341 483 3.4E-48 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 Gene3D G3DSA:3.40.1190.10 106 340 2.0E-71 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS47320 3e5eeb33500ef14b13aaeca6030f75b5 492 Hamap MF_00208 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [murE]. 1 490 31.264 T 17-03-2017 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 SUPERFAMILY SSF143800 1 66 1.53E-24 T 17-03-2017 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 ProSitePatterns PS01143 Ribosomal protein L31 signature. 36 57 - T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 Pfam PF01197 Ribosomal protein L31 2 66 1.3E-29 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 PRINTS PR01249 Ribosomal protein L31 signature 32 47 1.2E-20 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 PRINTS PR01249 Ribosomal protein L31 signature 47 65 1.2E-20 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 PRINTS PR01249 Ribosomal protein L31 signature 2 19 1.2E-20 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 TIGRFAM TIGR00105 L31: ribosomal protein bL31 2 67 1.9E-33 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS35190 e040b16053ee3dad49b57401ecc610c6 74 Hamap MF_00501 50S ribosomal protein L31 [rpmE]. 1 69 29.656 T 17-03-2017 IPR027491 Ribosomal protein L31 type A GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 425 562 2.8E-9 T 17-03-2017 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Pfam PF01077 Nitrite and sulphite reductase 4Fe-4S domain 172 325 1.2E-40 T 17-03-2017 IPR006067 Nitrite/sulphite reductase 4Fe-4S domain GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 PRINTS PR00397 Sirohaem Fe-binding site signature 470 488 1.4E-9 T 17-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 PRINTS PR00397 Sirohaem Fe-binding site signature 425 443 1.4E-9 T 17-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 SUPERFAMILY SSF55124 304 436 3.63E-21 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 101 162 4.1E-21 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 348 413 5.3E-15 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 SUPERFAMILY SSF56014 421 564 1.57E-37 T 17-03-2017 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 SUPERFAMILY SSF56014 172 333 1.57E-46 T 17-03-2017 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Gene3D G3DSA:3.90.480.10 101 169 4.0E-49 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Gene3D G3DSA:3.90.480.10 341 417 4.0E-49 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Gene3D G3DSA:3.30.413.10 422 564 2.7E-37 T 17-03-2017 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 ProSitePatterns PS00365 Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. 470 486 - T 17-03-2017 IPR006066 Nitrite/sulphite reductase iron-sulphur/sirohaem-binding site GO:0016491|GO:0020037|GO:0051536|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 SUPERFAMILY SSF55124 21 171 4.94E-38 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS38750 c6c8d6e68de8d1725d84cd101857eb37 564 Gene3D G3DSA:3.30.413.10 172 325 3.1E-43 T 17-03-2017 SHXM_RS03180 ea651ca9ff18197e9e42fc7ec23488bf 65 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 7 60 9.2E-13 T 17-03-2017 SHXM_RS03180 ea651ca9ff18197e9e42fc7ec23488bf 65 SUPERFAMILY SSF54862 3 62 1.12E-11 T 17-03-2017 SHXM_RS03180 ea651ca9ff18197e9e42fc7ec23488bf 65 Gene3D G3DSA:3.30.70.20 1 64 3.4E-16 T 17-03-2017 SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 SUPERFAMILY SSF56645 9 166 1.96E-19 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 PIRSF PIRSF016578 9 354 1.8E-47 T 17-03-2017 SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 Gene3D G3DSA:1.10.540.10 12 67 2.1E-12 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 Gene3D G3DSA:1.20.140.10 161 336 1.2E-21 T 17-03-2017 SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 204 335 3.1E-9 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 SUPERFAMILY SSF47203 203 335 2.19E-5 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS50600 0361a653165da2e0aa4290974ca68f9b 377 Gene3D G3DSA:2.40.110.10 78 160 1.7E-17 T 17-03-2017 SHXM_RS24040 b193ed0af135ea9fabbf4b0b8bd41ef5 669 Gene3D G3DSA:3.90.550.10 7 244 5.4E-44 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24040 b193ed0af135ea9fabbf4b0b8bd41ef5 669 SUPERFAMILY SSF53448 7 215 1.25E-46 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24040 b193ed0af135ea9fabbf4b0b8bd41ef5 669 Pfam PF00535 Glycosyl transferase family 2 10 141 5.1E-32 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 SUPERFAMILY SSF52540 35 271 6.69E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 Pfam PF00005 ABC transporter 51 192 1.2E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 SUPERFAMILY SSF50331 262 365 4.25E-14 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 Gene3D G3DSA:2.40.50.140 291 344 5.1E-9 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 SMART SM00382 59 242 1.1E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 Pfam PF08402 TOBE domain 289 351 1.3E-4 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 Gene3D G3DSA:3.40.50.300 33 265 1.1E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49695 e75876726384e5ce356f52751c2aec17 366 ProSitePatterns PS00211 ABC transporters family signature. 165 179 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00823 Phosphopantetheine attachment site 1728 1800 7.6E-35 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00823 Phosphopantetheine attachment site 3496 3568 6.7E-33 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF51735 1237 1425 8.76E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00825 Beta-ketoacyl synthase 50 476 1.5E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00825 Beta-ketoacyl synthase 1825 2250 7.5E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 211 227 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.366.10 2544 2655 1.5E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.366.10 779 892 6.9E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.366.10 2352 2475 1.5E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.366.10 585 710 6.9E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF52151 2355 2475 1.54E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF52151 2537 2645 1.54E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:1.10.1200.10 3496 3568 1.7E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:1.10.1200.10 1725 1800 1.6E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF101173 16 48 8.89E-6 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF53901 45 419 1.87E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.47.10 311 475 2.7E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.47.10 2084 2252 4.6E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF52151 780 879 4.45E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF52151 591 716 4.45E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF55048 2480 2544 3.4E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3209 3389 5.8E-56 T 17-03-2017 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1441 1621 2.1E-53 T 17-03-2017 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1984 2000 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF53901 1819 2195 1.51E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2200 2321 2.5E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 426 556 5.7E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00826 2717 2883 1.3E-86 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00826 956 1119 4.4E-73 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF51735 1440 1692 1.51E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF00550 Phosphopantetheine attachment site 3498 3564 1.6E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF00550 Phosphopantetheine attachment site 1735 1796 3.1E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2079 2197 7.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 306 423 9.2E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2358 2650 4.3E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 594 888 2.5E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF51735 3004 3193 1.15E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 48 298 2.3E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1823 2071 1.1E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF47336 3489 3577 1.14E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF55048 714 779 1.18E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.47.10 50 310 1.4E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.47.10 1825 2083 1.9E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF00698 Acyl transferase domain 593 906 4.0E-87 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF00698 Acyl transferase domain 2358 2639 5.0E-53 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM01294 3497 3564 3.0E-5 T 17-03-2017 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SMART SM01294 1729 1796 1.0E-6 T 17-03-2017 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF08990 Erythronolide synthase docking 16 41 8.0E-13 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.50.720 1442 1625 1.3E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.50.720 3464 3495 2.9E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.40.50.720 3209 3391 2.9E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF51735 3207 3432 9.71E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 SUPERFAMILY SSF47336 1723 1838 6.02E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.30.70.250 2480 2543 3.6E-6 T 17-03-2017 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Gene3D G3DSA:3.30.70.250 714 778 1.6E-7 T 17-03-2017 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3523 3538 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF08659 KR domain 1441 1620 6.2E-52 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF08659 KR domain 3209 3388 7.2E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1755 1770 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF14765 Polyketide synthase dehydratase 956 1231 2.8E-50 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04355 5d993993019e3fd1837df7369e4e9914 3652 Pfam PF14765 Polyketide synthase dehydratase 2717 2994 2.5E-56 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 SUPERFAMILY SSF48498 119 209 1.04E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 Gene3D G3DSA:1.10.357.10 93 211 1.9E-21 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 SUPERFAMILY SSF46689 26 87 6.98E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 61 84 7.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 53 7.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 Gene3D G3DSA:1.10.10.60 26 86 1.3E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05765 ab2ba5970ace984b2400e845f57884df 220 Pfam PF00440 Bacterial regulatory proteins, tetR family 40 86 1.1E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS21450 cc8e14ff69e9612effcfd8e7a7b6d1a1 1017 Pfam PF01526 Tn3 transposase DDE domain 608 995 8.8E-135 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS21450 cc8e14ff69e9612effcfd8e7a7b6d1a1 1017 Pfam PF13700 Domain of unknown function (DUF4158) 5 171 5.6E-52 T 17-03-2017 IPR025296 Domain of unknown function DUF4158 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 Pfam PF00027 Cyclic nucleotide-binding domain 29 110 5.1E-26 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 SUPERFAMILY SSF46785 145 222 2.93E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 ProSitePatterns PS00889 Cyclic nucleotide-binding domain signature 2. 78 95 - T 17-03-2017 IPR018488 Cyclic nucleotide-binding, conserved site SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 SUPERFAMILY SSF51206 3 142 2.62E-39 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 Gene3D G3DSA:2.60.120.10 2 143 7.7E-41 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 SMART SM00419 167 215 2.1E-13 T 17-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 PRINTS PR00103 cAMP-dependent protein kinase signature 31 45 2.4E-6 T 17-03-2017 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 PRINTS PR00103 cAMP-dependent protein kinase signature 46 60 2.4E-6 T 17-03-2017 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 PRINTS PR00103 cAMP-dependent protein kinase signature 76 85 2.4E-6 T 17-03-2017 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 PRINTS PR00103 cAMP-dependent protein kinase signature 88 99 2.4E-6 T 17-03-2017 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 SMART SM00100 10 128 5.4E-27 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 Pfam PF13545 Crp-like helix-turn-helix domain 148 221 4.3E-17 T 17-03-2017 IPR012318 Crp-type HTH domain GO:0003677|GO:0006355 SHXM_RS27000 724fae88e2d00607973c989a828042a9 224 Gene3D G3DSA:1.10.10.10 145 222 6.5E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 Gene3D G3DSA:3.90.180.10 44 228 9.6E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 SUPERFAMILY SSF51735 192 380 1.1E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 Gene3D G3DSA:3.40.50.720 229 361 5.3E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 Pfam PF00107 Zinc-binding dehydrogenase 233 376 8.4E-28 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 TIGRFAM TIGR01751 crot-CoA-red: crotonyl-CoA carboxylase/reductase 32 425 1.5E-159 T 17-03-2017 IPR010085 Crotonyl-CoA reductase GO:0043880 KEGG: 00650+1.3.1.86 SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 SUPERFAMILY SSF50129 49 227 7.55E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 65 186 2.4E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 222 243 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS39685 7777f66ff681520c11c844feb1c8e66c 452 SMART SM00829 46 412 1.1E-8 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS39030 de6767a3dd9410141f2e76c893b441ba 389 Gene3D G3DSA:1.10.260.40 10 104 6.8E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39030 de6767a3dd9410141f2e76c893b441ba 389 Pfam PF01381 Helix-turn-helix 16 67 2.2E-12 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS39030 de6767a3dd9410141f2e76c893b441ba 389 SMART SM00530 12 67 5.7E-13 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS39030 de6767a3dd9410141f2e76c893b441ba 389 SUPERFAMILY SSF47413 10 72 9.29E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22280 ea7fd8aee9fe70011248761b938ecfab 306 Pfam PF01261 Xylose isomerase-like TIM barrel 40 242 2.9E-29 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS22280 ea7fd8aee9fe70011248761b938ecfab 306 Gene3D G3DSA:3.20.20.150 9 305 4.3E-62 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS22280 ea7fd8aee9fe70011248761b938ecfab 306 SUPERFAMILY SSF51658 11 289 1.31E-48 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 TIGRFAM TIGR00170 leuC: 3-isopropylmalate dehydratase, large subunit 1 460 7.0E-224 T 17-03-2017 IPR004430 3-isopropylmalate dehydratase, large subunit GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 ProSitePatterns PS00450 Aconitase family signature 1. 339 355 - T 17-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 Gene3D G3DSA:3.40.1060.10 152 288 2.0E-39 T 17-03-2017 IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 ProSitePatterns PS01244 Aconitase family signature 2. 399 412 - T 17-03-2017 IPR018136 Aconitase family, 4Fe-4S cluster binding site KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 Gene3D G3DSA:3.30.499.10 335 466 3.3E-57 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 Gene3D G3DSA:3.30.499.10 2 151 2.1E-21 T 17-03-2017 IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3 GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 Hamap MF_01026 3-isopropylmalate dehydratase large subunit [leuC]. 1 466 59.273 T 17-03-2017 IPR004430 3-isopropylmalate dehydratase, large subunit GO:0003861|GO:0009098|GO:0051539 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 108 116 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 343 354 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 195 208 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 286 300 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 209 222 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 133 148 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 119 132 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 399 412 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 PRINTS PR00415 Aconitase family signature 82 95 2.5E-46 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 Pfam PF00330 Aconitase family (aconitate hydratase) 7 457 2.7E-150 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS36355 79a130dcf5bd9f1b53e3db45358f2d17 476 SUPERFAMILY SSF53732 1 465 4.45E-161 T 17-03-2017 IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain GO:0008152 KEGG: 00290+4.2.1.33 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 Gene3D G3DSA:1.10.10.10 1 86 4.4E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 Gene3D G3DSA:3.40.190.10 188 245 1.5E-10 T 17-03-2017 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 1.7E-17 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.7E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.7E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.7E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 Gene3D G3DSA:3.40.190.10 112 187 2.1E-7 T 17-03-2017 SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 Pfam PF03466 LysR substrate binding domain 104 286 1.9E-14 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 SUPERFAMILY SSF46785 1 82 9.25E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46525 20824c350e374635461d7130fb8451b8 300 SUPERFAMILY SSF53850 103 286 1.21E-14 T 17-03-2017 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Gene3D G3DSA:2.60.40.10 170 249 4.9E-19 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Gene3D G3DSA:2.60.40.10 338 417 1.2E-18 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Gene3D G3DSA:2.60.40.10 252 330 4.5E-14 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Gene3D G3DSA:2.60.40.10 2 82 1.7E-19 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Gene3D G3DSA:2.60.40.10 87 166 2.8E-18 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SUPERFAMILY SSF81296 87 165 8.29E-14 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SUPERFAMILY SSF81296 338 417 5.23E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SUPERFAMILY SSF81296 2 82 9.37E-17 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SUPERFAMILY SSF81296 252 326 3.82E-12 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SUPERFAMILY SSF81296 169 249 2.57E-15 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SMART SM00429 87 166 9.8E-9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SMART SM00429 170 250 0.011 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SMART SM00429 338 418 9.3E-7 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SMART SM00429 252 336 0.0042 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 SMART SM00429 2 83 1.4E-5 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Pfam PF01833 IPT/TIG domain 339 417 1.1E-11 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Pfam PF01833 IPT/TIG domain 171 249 1.4E-13 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Pfam PF01833 IPT/TIG domain 88 165 4.2E-14 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Pfam PF01833 IPT/TIG domain 3 82 4.5E-13 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15845 58f1f644abd107e04ec393cf5a37524a 420 Pfam PF01833 IPT/TIG domain 253 328 3.0E-9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 Pfam PF07702 UTRA domain 97 232 5.2E-37 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 SMART SM00345 15 72 1.0E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 Gene3D G3DSA:3.40.1410.10 70 237 5.6E-45 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 SMART SM00866 92 232 3.9E-34 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 Pfam PF00392 Bacterial regulatory proteins, gntR family 27 72 6.2E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 SUPERFAMILY SSF46785 13 81 3.01E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 Gene3D G3DSA:1.10.10.10 24 69 6.6E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 SUPERFAMILY SSF64288 60 238 1.88E-43 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 32 46 1.6E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS40365 ea1d6e3151a98d3546723489dfab6f56 279 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 46 62 1.6E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 Pfam PF02872 5'-nucleotidase, C-terminal domain 372 551 2.2E-30 T 17-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 SUPERFAMILY SSF55816 369 581 5.89E-41 T 17-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 Gene3D G3DSA:3.60.21.10 42 370 4.8E-75 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 Pfam PF00149 Calcineurin-like phosphoesterase 44 291 5.2E-11 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 SUPERFAMILY SSF56300 41 371 1.86E-74 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 PRINTS PR01607 Apyrase family signature 526 545 3.9E-25 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 PRINTS PR01607 Apyrase family signature 42 60 3.9E-25 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 PRINTS PR01607 Apyrase family signature 241 258 3.9E-25 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 PRINTS PR01607 Apyrase family signature 435 458 3.9E-25 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 PRINTS PR01607 Apyrase family signature 274 297 3.9E-25 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 PRINTS PR01607 Apyrase family signature 307 327 3.9E-25 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 Gene3D G3DSA:3.90.780.10 372 581 7.5E-41 T 17-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS18200 4f40b806a695f3b5713d00e998464399 602 ProSitePatterns PS00786 5'-nucleotidase signature 2. 139 150 - T 17-03-2017 IPR006146 5'-Nucleotidase, conserved site GO:0000166|GO:0016788|GO:0046872 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 Gene3D G3DSA:3.40.1410.10 87 258 7.6E-38 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 Gene3D G3DSA:1.10.10.10 24 86 1.5E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 SUPERFAMILY SSF64288 78 258 2.36E-37 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 SMART SM00866 111 251 3.9E-23 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 SUPERFAMILY SSF46785 24 93 2.48E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 Pfam PF00392 Bacterial regulatory proteins, gntR family 29 90 3.6E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 64 2.3E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 64 80 2.3E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 SMART SM00345 31 90 2.6E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49025 ed33b0c9d993760816ccc04742b0445b 276 Pfam PF07702 UTRA domain 111 250 9.4E-29 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 SUPERFAMILY SSF46894 151 219 8.5E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 Pfam PF00196 Bacterial regulatory proteins, luxR family 158 213 5.2E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 SMART SM00448 3 116 8.1E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 SUPERFAMILY SSF52172 1 135 2.85E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 ProSitePatterns PS00622 LuxR-type HTH domain signature. 173 200 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 Pfam PF00072 Response regulator receiver domain 5 117 1.1E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 Gene3D G3DSA:3.40.50.2300 1 123 1.1E-37 T 17-03-2017 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 Gene3D G3DSA:1.10.10.10 124 220 3.0E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 SMART SM00421 156 213 5.0E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 173 3.0E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 189 3.0E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26365 670a300972ff076336351eeaadc90ca1 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 189 201 3.0E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS11880 6c3ccdba25f381bae007f2c4c61fd373 410 Pfam PF12704 MacB-like periplasmic core domain 44 206 1.6E-11 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS11880 6c3ccdba25f381bae007f2c4c61fd373 410 Pfam PF02687 FtsX-like permease family 291 403 7.2E-23 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 Gene3D G3DSA:2.60.40.670 537 620 2.9E-23 T 17-03-2017 IPR000601 PKD domain SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 Gene3D G3DSA:2.120.10.30 69 536 4.6E-101 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 Pfam PF03422 Carbohydrate binding module (family 6) 732 853 9.2E-35 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 Pfam PF00801 PKD domain 542 608 3.6E-13 T 17-03-2017 IPR000601 PKD domain SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 Pfam PF07995 Glucose / Sorbosone dehydrogenase 100 387 2.0E-34 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 SUPERFAMILY SSF49785 728 853 1.84E-26 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 SUPERFAMILY SSF50952 85 400 3.14E-23 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 SUPERFAMILY SSF50952 435 512 3.14E-23 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 SMART SM00606 724 855 3.6E-46 T 17-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 SMART SM00089 537 620 1.0E-21 T 17-03-2017 IPR022409 PKD/Chitinase domain SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 Gene3D G3DSA:2.60.120.260 727 853 1.0E-40 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS14185 a1649530a12cf8bf3946f4fbcec8cfd6 856 SUPERFAMILY SSF49299 535 619 9.68E-23 T 17-03-2017 IPR000601 PKD domain SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 SUPERFAMILY SSF81442 25 535 7.33E-176 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 257 311 - T 17-03-2017 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 Gene3D G3DSA:1.20.210.10 25 543 5.3E-192 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 323 344 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 234 255 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 144 156 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 205 224 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 436 457 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 301 316 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 176 194 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 255 276 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 358 376 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 27 52 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 74 97 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 386 405 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 PRINTS PR01165 Cytochrome c oxidase subunit I signature 101 125 2.2E-101 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 37 480 3.5E-145 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS07025 7e006e2076548187071bb52806a344e8 554 TIGRFAM TIGR02891 CtaD_CoxA: cytochrome c oxidase, subunit I 28 533 2.0E-213 T 17-03-2017 IPR014241 Cytochrome c oxidase, subunit I bacterial type GO:0004129|GO:0005507|GO:0005886|GO:0006810|GO:0022900|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 SHXM_RS03945 db148720cae67cfd225b81805cd74bf8 442 SUPERFAMILY SSF54826 4 133 6.9E-31 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS03945 db148720cae67cfd225b81805cd74bf8 442 Pfam PF13378 Enolase C-terminal domain-like 184 401 2.1E-36 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03945 db148720cae67cfd225b81805cd74bf8 442 SUPERFAMILY SSF51604 135 411 2.36E-78 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03945 db148720cae67cfd225b81805cd74bf8 442 Gene3D G3DSA:3.20.20.120 119 394 4.8E-98 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS03945 db148720cae67cfd225b81805cd74bf8 442 Gene3D G3DSA:3.30.390.10 21 118 3.7E-10 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS03945 db148720cae67cfd225b81805cd74bf8 442 SMART SM00922 181 281 4.0E-18 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS00545 4b6287ec2a2bcb310f141343d58df772 168 Gene3D G3DSA:3.40.630.30 1 166 7.8E-46 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS00545 4b6287ec2a2bcb310f141343d58df772 168 Pfam PF00583 Acetyltransferase (GNAT) family 69 142 1.4E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS00545 4b6287ec2a2bcb310f141343d58df772 168 SUPERFAMILY SSF55729 1 142 9.22E-27 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS01690 01ed61d7272af3f4747a51cd209da3eb 155 Pfam PF12802 MarR family 40 99 1.0E-10 T 17-03-2017 SHXM_RS01690 01ed61d7272af3f4747a51cd209da3eb 155 SUPERFAMILY SSF46785 7 151 7.45E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01690 01ed61d7272af3f4747a51cd209da3eb 155 SMART SM00347 33 136 7.8E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01690 01ed61d7272af3f4747a51cd209da3eb 155 Gene3D G3DSA:1.10.10.10 2 153 2.8E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29270 f1cf74fd1155a2144daeaf5a1143bb4e 486 Pfam PF07730 Histidine kinase 224 288 4.4E-19 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS29270 f1cf74fd1155a2144daeaf5a1143bb4e 486 SUPERFAMILY SSF55874 311 428 4.28E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50340 c270026de0a543e6e58a8798d78fcf9e 374 Pfam PF09084 NMT1/THI5 like 109 283 7.5E-18 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS50340 c270026de0a543e6e58a8798d78fcf9e 374 Gene3D G3DSA:3.40.190.10 151 270 3.6E-24 T 17-03-2017 SHXM_RS50340 c270026de0a543e6e58a8798d78fcf9e 374 SUPERFAMILY SSF53850 61 289 2.43E-37 T 17-03-2017 SHXM_RS50340 c270026de0a543e6e58a8798d78fcf9e 374 SMART SM00062 62 283 0.0049 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS14520 ebcfaf546b764a34c0381cece7cb4406 135 Pfam PF07883 Cupin domain 42 108 7.8E-20 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS14520 ebcfaf546b764a34c0381cece7cb4406 135 SUPERFAMILY SSF51182 5 128 2.23E-28 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS14520 ebcfaf546b764a34c0381cece7cb4406 135 PIRSF PIRSF016602 1 135 1.9E-56 T 17-03-2017 IPR016672 Polyketide biosynthesis protein CurC, predicted SHXM_RS14520 ebcfaf546b764a34c0381cece7cb4406 135 Gene3D G3DSA:2.60.120.10 21 118 1.3E-24 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS25040 3fb9ea8499d0afd1bb7e122f77b8bb0b 699 SUPERFAMILY SSF53448 316 581 1.21E-61 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS25040 3fb9ea8499d0afd1bb7e122f77b8bb0b 699 Gene3D G3DSA:3.20.20.370 17 181 4.8E-29 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS25040 3fb9ea8499d0afd1bb7e122f77b8bb0b 699 Pfam PF01522 Polysaccharide deacetylase 76 184 1.9E-19 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS25040 3fb9ea8499d0afd1bb7e122f77b8bb0b 699 Gene3D G3DSA:3.90.550.10 329 561 4.2E-52 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS25040 3fb9ea8499d0afd1bb7e122f77b8bb0b 699 Pfam PF13641 Glycosyltransferase like family 2 329 548 4.5E-36 T 17-03-2017 SHXM_RS25040 3fb9ea8499d0afd1bb7e122f77b8bb0b 699 SUPERFAMILY SSF88713 71 208 5.28E-28 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS02635 aba1aaa0bf80a001eb54af4cc3318027 279 SUPERFAMILY SSF53167 1 242 4.7E-38 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS02635 aba1aaa0bf80a001eb54af4cc3318027 279 Gene3D G3DSA:3.40.50.1580 1 243 5.0E-44 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS02635 aba1aaa0bf80a001eb54af4cc3318027 279 Pfam PF01048 Phosphorylase superfamily 2 239 7.6E-30 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 Gene3D G3DSA:3.40.50.720 151 192 3.3E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 SMART SM00829 10 307 7.4E-11 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 SUPERFAMILY SSF50129 1 149 6.54E-38 T 17-03-2017 IPR011032 GroES-like SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 SUPERFAMILY SSF51735 117 240 9.05E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 Pfam PF13602 Zinc-binding dehydrogenase 204 307 7.8E-8 T 17-03-2017 SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 Gene3D G3DSA:3.90.180.10 1 150 5.8E-44 T 17-03-2017 IPR011032 GroES-like SHXM_RS41235 66e644f944c8cff4ea8e21ae6274d77c 310 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 90 4.0E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS46105 98d1b2bfd7c2269da274dddf7797dd94 261 SUPERFAMILY SSF161098 53 245 1.57E-39 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46105 98d1b2bfd7c2269da274dddf7797dd94 261 Gene3D G3DSA:1.10.3720.10 54 257 3.7E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46105 98d1b2bfd7c2269da274dddf7797dd94 261 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 54 149 7.6E-20 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS46105 98d1b2bfd7c2269da274dddf7797dd94 261 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 72 256 2.1E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 SUPERFAMILY SSF48498 96 206 6.67E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 Gene3D G3DSA:1.10.10.60 26 72 2.1E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 SUPERFAMILY SSF46689 26 85 6.98E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 36 78 2.5E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 48 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 56 79 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 Pfam PF16859 Bacterial transcriptional repressor C-terminal 93 203 2.9E-29 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS31865 eec607587049e198a5b4e1205334c112 216 Gene3D G3DSA:1.10.357.10 74 206 3.1E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 Gene3D G3DSA:2.30.30.230 7 115 6.8E-26 T 17-03-2017 IPR015377 Fumarylacetoacetase, N-terminal GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 SUPERFAMILY SSF56529 115 414 7.06E-87 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 119 412 9.5E-54 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 Pfam PF09298 Fumarylacetoacetase N-terminal 18 113 8.5E-17 T 17-03-2017 IPR015377 Fumarylacetoacetase, N-terminal GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 SUPERFAMILY SSF63433 4 113 9.42E-22 T 17-03-2017 IPR015377 Fumarylacetoacetase, N-terminal GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 Gene3D G3DSA:3.90.850.10 116 407 9.2E-104 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS30845 c17352561880b26c8b7a96470a10e1dc 416 TIGRFAM TIGR01266 fum_ac_acetase: fumarylacetoacetase 8 414 1.1E-124 T 17-03-2017 IPR005959 Fumarylacetoacetase GO:0004334|GO:0009072 KEGG: 00350+3.7.1.2|KEGG: 00643+3.7.1.2|Reactome: R-HSA-71182 SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 Gene3D G3DSA:3.40.640.10 14 245 8.8E-51 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 SUPERFAMILY SSF64307 408 481 6.54E-17 T 17-03-2017 IPR001455 TusA-like domain SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 Gene3D G3DSA:3.90.1150.10 246 370 2.7E-34 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 ProSitePatterns PS01148 Uncharacterized protein family UPF0033 signature. 414 438 - T 17-03-2017 IPR001455 TusA-like domain SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 SUPERFAMILY SSF53383 3 375 2.8E-71 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 Gene3D G3DSA:3.30.110.40 409 481 1.1E-18 T 17-03-2017 IPR001455 TusA-like domain SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 Pfam PF00266 Aminotransferase class-V 3 365 1.7E-37 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS18915 93c5cd5d20f61dfafddfe9099d997af4 483 Pfam PF01206 Sulfurtransferase TusA 413 481 1.6E-13 T 17-03-2017 IPR001455 TusA-like domain SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 Gene3D G3DSA:3.20.20.80 140 529 5.6E-137 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 476 493 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 458 474 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 91 111 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 165 186 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 236 253 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 287 305 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PRINTS PR00738 Glycosyl hydrolase family 20 signature 309 322 7.5E-36 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 SUPERFAMILY SSF51445 142 510 4.04E-115 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 142 494 1.4E-122 T 17-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 PIRSF PIRSF001093 72 537 7.3E-76 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 8 138 1.7E-17 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 SUPERFAMILY SSF55545 5 141 1.16E-18 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS23655 83a14c31e413d24fc6bdcdd307a6d313 551 Gene3D G3DSA:3.30.379.10 7 139 5.7E-23 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS16340 910aa5b8666dafa0cd05a1f281819d8e 138 Pfam PF01638 HxlR-like helix-turn-helix 29 115 3.5E-24 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS16340 910aa5b8666dafa0cd05a1f281819d8e 138 SUPERFAMILY SSF46785 18 127 4.02E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16340 910aa5b8666dafa0cd05a1f281819d8e 138 Gene3D G3DSA:1.10.10.10 15 127 8.5E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 Gene3D G3DSA:3.40.50.720 4 256 1.7E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 SUPERFAMILY SSF51735 7 256 5.95E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 256 4.3E-47 T 17-03-2017 SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 6.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 6.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 6.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 220 240 6.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 6.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15315 830e5f2f478dfc355054a972f42640ce 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 6.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41810 7be8b7a833dc3c8a34c1e94a69b08ee4 187 Gene3D G3DSA:1.10.357.10 60 182 3.4E-19 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41810 7be8b7a833dc3c8a34c1e94a69b08ee4 187 SUPERFAMILY SSF48498 78 182 1.56E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41810 7be8b7a833dc3c8a34c1e94a69b08ee4 187 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 63 1.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41810 7be8b7a833dc3c8a34c1e94a69b08ee4 187 SUPERFAMILY SSF46689 10 70 6.16E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41810 7be8b7a833dc3c8a34c1e94a69b08ee4 187 Pfam PF16859 Bacterial transcriptional repressor C-terminal 77 179 3.0E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41810 7be8b7a833dc3c8a34c1e94a69b08ee4 187 Gene3D G3DSA:1.10.10.60 9 57 9.9E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38515 d732c585b50d9546bcfd3766c9fa8221 384 Pfam PF01385 Probable transposase 182 269 6.6E-10 T 17-03-2017 IPR001959 Probable transposase, IS891/IS1136/IS1341 SHXM_RS38515 d732c585b50d9546bcfd3766c9fa8221 384 Gene3D G3DSA:1.25.40.40 16 55 3.4E-4 T 17-03-2017 IPR003204 Cytochrome c oxidase, subunit Va/VI GO:0004129|GO:0005743 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS38515 d732c585b50d9546bcfd3766c9fa8221 384 Pfam PF07282 Putative transposase DNA-binding domain 300 369 3.9E-18 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS38515 d732c585b50d9546bcfd3766c9fa8221 384 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 248 327 2.7E-15 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS30895 57d21caeffbba142d53bd1c58cf76f8d 654 Pfam PF13520 Amino acid permease 42 461 9.5E-28 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 Pfam PF07729 FCD domain 78 201 1.6E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 SUPERFAMILY SSF48008 75 208 2.88E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 SUPERFAMILY SSF46785 6 72 4.67E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 Gene3D G3DSA:1.10.10.10 3 70 6.5E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 SMART SM00345 10 68 7.3E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 Pfam PF00392 Bacterial regulatory proteins, gntR family 8 68 3.9E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 Gene3D G3DSA:1.20.120.530 73 207 7.5E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 SMART SM00895 78 202 4.2E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 58 1.1E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS19155 cb573207f8764bf5f3bc5109f566938e 210 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 28 42 1.1E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 15 31 6.0E-7 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 201 214 6.0E-7 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 SUPERFAMILY SSF53335 15 99 2.19E-43 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 SUPERFAMILY SSF53335 129 380 2.19E-43 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 Gene3D G3DSA:3.40.50.150 14 212 4.2E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 Pfam PF00145 C-5 cytosine-specific DNA methylase 184 381 9.9E-10 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 Pfam PF00145 C-5 cytosine-specific DNA methylase 15 96 2.7E-15 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 Gene3D G3DSA:3.90.120.10 213 373 5.0E-15 T 17-03-2017 SHXM_RS29730 5e135eb0e84e992371793b3004a26634 438 ProSitePatterns PS00094 C-5 cytosine-specific DNA methylases active site. 78 90 - T 17-03-2017 IPR018117 DNA methylase, C-5 cytosine-specific, active site KEGG: 00270+2.1.1.37|Reactome: R-HSA-212300|Reactome: R-HSA-5334118 SHXM_RS23245 65d130990c8fb4bcf50f5df674a7b263 610 Gene3D G3DSA:3.90.550.10 179 419 1.0E-10 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS23245 65d130990c8fb4bcf50f5df674a7b263 610 SUPERFAMILY SSF53448 169 435 4.39E-36 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS23245 65d130990c8fb4bcf50f5df674a7b263 610 Pfam PF13506 Glycosyl transferase family 21 234 403 5.0E-17 T 17-03-2017 IPR025993 Ceramide glucosyltransferase GO:0016757 KEGG: 00600+2.4.1.80|MetaCyc: PWY-5129|Reactome: R-HSA-1660662 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Gene3D G3DSA:2.60.40.10 78 158 1.9E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Gene3D G3DSA:2.60.40.10 3 74 1.2E-10 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Gene3D G3DSA:2.60.40.10 161 243 1.0E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 SMART SM00429 1 77 3.9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 SMART SM00429 79 160 4.3E-4 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 SMART SM00429 162 244 0.15 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 SUPERFAMILY SSF81296 162 243 3.4E-14 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Pfam PF01833 IPT/TIG domain 163 243 5.3E-12 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Pfam PF01833 IPT/TIG domain 80 152 5.8E-15 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Pfam PF01833 IPT/TIG domain 3 66 2.9E-5 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 Pfam PF11999 Protein of unknown function (DUF3494) 249 435 6.4E-69 T 17-03-2017 IPR021884 Protein of unknown function DUF3494 SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 SUPERFAMILY SSF81296 3 69 1.2E-10 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS47210 359407fbe9c50c7a6e9cdd53ec579b1f 438 SUPERFAMILY SSF81296 78 156 9.93E-15 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS02210 07cc61aa78ad279d6855056ad058a174 330 SMART SM00382 43 234 2.4E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02210 07cc61aa78ad279d6855056ad058a174 330 Pfam PF00005 ABC transporter 34 177 6.4E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS02210 07cc61aa78ad279d6855056ad058a174 330 SUPERFAMILY SSF52540 18 239 2.56E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02210 07cc61aa78ad279d6855056ad058a174 330 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 26 323 5.1E-103 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS02210 07cc61aa78ad279d6855056ad058a174 330 Gene3D G3DSA:3.40.50.300 16 243 3.8E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02210 07cc61aa78ad279d6855056ad058a174 330 Pfam PF13732 Domain of unknown function (DUF4162) 231 321 8.9E-7 T 17-03-2017 IPR025302 Domain of unknown function DUF4162 SHXM_RS04820 f74cb57f04b2f27390a67e92d0336f26 231 Gene3D G3DSA:3.40.50.880 1 231 3.6E-85 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS04820 f74cb57f04b2f27390a67e92d0336f26 231 Pfam PF01965 DJ-1/PfpI family 30 228 1.1E-16 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS04820 f74cb57f04b2f27390a67e92d0336f26 231 SUPERFAMILY SSF52317 2 230 4.95E-62 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 3.2E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 3.2E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 3.2E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 Gene3D G3DSA:1.10.10.10 2 53 1.1E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 SMART SM00344 1 110 5.9E-43 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 Pfam PF01037 Lrp/AsnC ligand binding domain 76 140 7.0E-19 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 Gene3D G3DSA:3.30.70.920 54 149 1.7E-25 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 SUPERFAMILY SSF46785 1 60 8.8E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 SUPERFAMILY SSF54909 66 149 5.23E-17 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS44185 de06a3e9c398ead19ccf5187171520bf 150 Pfam PF13412 Winged helix-turn-helix DNA-binding 1 48 1.6E-18 T 17-03-2017 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 Gene3D G3DSA:3.30.70.270 17 92 8.8E-8 T 17-03-2017 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 Gene3D G3DSA:1.10.150.20 122 196 7.4E-17 T 17-03-2017 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 Pfam PF14520 Helix-hairpin-helix domain 136 182 1.8E-6 T 17-03-2017 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 Pfam PF00817 impB/mucB/samB family 2 89 8.8E-8 T 17-03-2017 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 SUPERFAMILY SSF100879 198 295 9.61E-13 T 17-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 SUPERFAMILY SSF56672 2 192 1.11E-27 T 17-03-2017 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 Gene3D G3DSA:3.30.1490.100 201 303 5.5E-13 T 17-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS16870 0b7c62726f2753b1ac6d456e619fec27 345 Pfam PF11799 impB/mucB/samB family C-terminal domain 194 302 5.5E-11 T 17-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 Gene3D G3DSA:3.50.50.60 380 431 6.3E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 Gene3D G3DSA:3.50.50.60 43 143 6.3E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 Gene3D G3DSA:3.50.50.60 200 276 6.3E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 Gene3D G3DSA:3.30.9.10 147 199 3.3E-7 T 17-03-2017 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 Gene3D G3DSA:3.30.9.10 277 377 3.3E-7 T 17-03-2017 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 SUPERFAMILY SSF51905 30 146 6.39E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 SUPERFAMILY SSF51905 202 336 6.39E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS36795 342abe5f1eebd334c18c4ef3f6474266 482 Pfam PF01266 FAD dependent oxidoreductase 53 416 1.0E-50 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS09200 a6bead6bb8144426bb9e1dd561618629 488 TIGRFAM TIGR00924 yjdL_sub1_fam: amino acid/peptide transporter (Peptide:H+ symporter) 19 485 1.2E-93 T 17-03-2017 IPR005279 Dipeptide/tripeptide permease GO:0015197|GO:0015833|GO:0016020 SHXM_RS09200 a6bead6bb8144426bb9e1dd561618629 488 SUPERFAMILY SSF103473 270 481 1.44E-23 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS09200 a6bead6bb8144426bb9e1dd561618629 488 SUPERFAMILY SSF103473 13 215 1.44E-23 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS09200 a6bead6bb8144426bb9e1dd561618629 488 Pfam PF00854 POT family 94 452 6.4E-44 T 17-03-2017 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-427975 SHXM_RS09200 a6bead6bb8144426bb9e1dd561618629 488 Gene3D G3DSA:1.20.1250.20 24 206 1.0E-11 T 17-03-2017 SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 Gene3D G3DSA:1.10.10.10 27 73 1.4E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 SUPERFAMILY SSF46785 23 73 2.3E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 SUPERFAMILY SSF53067 142 434 2.04E-44 T 17-03-2017 SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 Pfam PF13412 Winged helix-turn-helix DNA-binding 35 67 1.4E-5 T 17-03-2017 SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 Pfam PF00480 ROK family 214 431 2.8E-35 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 Gene3D G3DSA:3.30.420.40 268 416 2.1E-43 T 17-03-2017 SHXM_RS11485 252bab2ec303c44dcb71d13f6f446ca5 485 Gene3D G3DSA:3.30.420.40 138 267 1.2E-20 T 17-03-2017 SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 Pfam PF00005 ABC transporter 42 192 2.7E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 Gene3D G3DSA:3.40.50.300 13 266 6.6E-84 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 SUPERFAMILY SSF52540 14 264 4.77E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 244 311 4.1E-18 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 ProSitePatterns PS00211 ABC transporters family signature. 165 179 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 242 330 1.3E-28 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS36000 9d02043f77a856c199b9c01042255a1a 358 SMART SM00382 50 242 5.2E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS05730 cb800d2712c9252d74f2325959f43f32 508 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 104 273 6.7E-41 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS05730 cb800d2712c9252d74f2325959f43f32 508 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 387 469 1.9E-17 T 17-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain SHXM_RS05730 cb800d2712c9252d74f2325959f43f32 508 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 103 273 1.4E-38 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 Pfam PF04488 Glycosyltransferase sugar-binding region containing DXD motif 21 99 8.4E-18 T 17-03-2017 IPR007577 Glycosyltransferase, DXD sugar-binding motif SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 SUPERFAMILY SSF53448 524 802 2.58E-15 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 SUPERFAMILY SSF53448 10 161 1.35E-29 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 SUPERFAMILY SSF53448 209 228 1.35E-29 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 Gene3D G3DSA:3.90.550.10 545 797 1.0E-4 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 Gene3D G3DSA:3.90.550.10 272 389 2.0E-21 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 Pfam PF00535 Glycosyl transferase family 2 275 388 2.3E-13 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 Pfam PF03452 Anp1 541 761 5.1E-40 T 17-03-2017 SHXM_RS22735 526f58ada3336c776371d2ea5f5f5a2b 820 SUPERFAMILY SSF53448 272 458 7.16E-24 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00825 Beta-ketoacyl synthase 1584 2010 3.3E-227 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00825 Beta-ketoacyl synthase 36 462 4.6E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.47.10 1584 1844 5.0E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.47.10 36 296 4.3E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF53901 1580 1955 3.76E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF47336 3042 3121 1.2E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1745 1761 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF52151 564 692 3.14E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF52151 757 855 3.14E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00823 Phosphopantetheine attachment site 3049 3121 2.4E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00823 Phosphopantetheine attachment site 1487 1559 1.9E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:1.10.1200.10 1485 1559 3.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:1.10.1200.10 3046 3119 9.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 567 865 5.4E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2118 2420 1.5E-127 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.50.720 1201 1383 2.9E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.50.720 2761 2974 6.7E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.366.10 557 687 9.1E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.366.10 756 878 9.1E-77 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF47336 1483 1597 1.96E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF51735 2532 2749 4.72E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF08990 Erythronolide synthase docking 2 26 6.6E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF51735 2759 2990 2.48E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 1.1E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1582 1832 6.1E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3076 3091 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF00550 Phosphopantetheine attachment site 3052 3117 6.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF00550 Phosphopantetheine attachment site 1489 1555 1.2E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF55048 2245 2309 2.22E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 529 1.2E-17 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1960 2078 8.8E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF52151 2302 2404 1.1E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF52151 2115 2240 1.1E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF51735 978 1188 3.46E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF51735 1198 1451 9.39E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.30.70.250 2245 2308 4.1E-7 T 17-03-2017 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.30.70.250 691 755 1.7E-8 T 17-03-2017 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF55048 691 756 5.23E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1514 1529 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.366.10 2108 2240 1.1E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.366.10 2309 2424 1.1E-83 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1202 1381 2.4E-54 T 17-03-2017 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2761 2940 3.3E-64 T 17-03-2017 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.47.10 297 463 4.5E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Gene3D G3DSA:3.40.47.10 1845 2010 3.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF08659 KR domain 2761 2939 7.2E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF08659 KR domain 1202 1380 8.1E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1841 1957 3.5E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 6.6E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF00698 Acyl transferase domain 2117 2439 3.1E-59 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 Pfam PF00698 Acyl transferase domain 565 882 6.1E-91 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SUPERFAMILY SSF53901 31 407 6.35E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM01294 1488 1555 1.1E-6 T 17-03-2017 SHXM_RS45370 5e8bf6d6f261a644ee32ffe58da35fcb 3205 SMART SM01294 3050 3117 1.3E-4 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 SUPERFAMILY SSF53067 4 182 4.7E-61 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 1 642 35.652 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 382 401 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 31 43 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 327 343 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 195 205 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 3 16 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 136 156 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 463 479 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 359 379 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 PRINTS PR00301 70kDa heat shock protein signature 54 62 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:2.60.34.10 384 526 2.9E-65 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:3.30.30.30 53 104 3.8E-18 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 SUPERFAMILY SSF100920 378 534 4.19E-57 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 3 596 3.5E-285 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:3.90.640.10 223 308 2.0E-28 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Pfam PF00012 Hsp70 protein 4 591 1.7E-240 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 SUPERFAMILY SSF53067 184 376 3.02E-64 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:3.30.420.40 4 52 8.0E-63 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:3.30.420.40 117 189 8.0E-63 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 7 14 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2. 189 202 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:3.30.420.40 312 354 3.2E-34 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:3.30.420.40 190 222 3.2E-34 T 17-03-2017 SHXM_RS40010 c1ac679c87b9b0cce8d9a8e69a2df488 642 Gene3D G3DSA:1.20.1270.10 527 594 8.3E-16 T 17-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 153 208 4.6E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 SUPERFAMILY SSF46894 147 213 3.03E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 SMART SM00448 4 117 3.6E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 Gene3D G3DSA:1.10.10.10 155 213 7.0E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 154 168 4.7E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 184 196 4.7E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 168 184 4.7E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 SMART SM00421 151 208 3.5E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 ProSitePatterns PS00622 LuxR-type HTH domain signature. 168 195 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 Gene3D G3DSA:3.40.50.2300 3 154 3.6E-34 T 17-03-2017 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 Pfam PF00072 Response regulator receiver domain 6 117 3.1E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS36515 f0453c9a93b4cab4018d03a336b1b05d 216 SUPERFAMILY SSF52172 3 133 4.7E-30 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20105 7dbd8ccb2f59fcdab78d32ac33aca40e 306 Pfam PF01738 Dienelactone hydrolase family 50 133 3.0E-4 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS20105 7dbd8ccb2f59fcdab78d32ac33aca40e 306 SUPERFAMILY SSF53474 230 306 2.14E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20105 7dbd8ccb2f59fcdab78d32ac33aca40e 306 SUPERFAMILY SSF53474 3 145 2.14E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20105 7dbd8ccb2f59fcdab78d32ac33aca40e 306 SUPERFAMILY SSF53474 178 187 2.14E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20105 7dbd8ccb2f59fcdab78d32ac33aca40e 306 Gene3D G3DSA:3.40.50.1820 5 306 8.7E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS12315 7d3db700c0fbce1bb2e50cd98bc9be5c 721 Hamap MF_00983 Probable primosomal protein N' [priA]. 57 720 20.462 T 17-03-2017 IPR005259 Primosomal protein N' GO:0003677|GO:0004003|GO:0006260|GO:0032508 SHXM_RS12315 7d3db700c0fbce1bb2e50cd98bc9be5c 721 Gene3D G3DSA:3.40.50.300 227 324 1.2E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12315 7d3db700c0fbce1bb2e50cd98bc9be5c 721 SUPERFAMILY SSF52540 225 315 1.73E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 SUPERFAMILY SSF54373 228 319 2.94E-5 T 17-03-2017 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 Gene3D G3DSA:3.50.50.60 320 380 3.0E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 Gene3D G3DSA:3.50.50.60 11 90 3.0E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 Gene3D G3DSA:3.50.50.60 149 227 3.0E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 Pfam PF01266 FAD dependent oxidoreductase 14 358 6.7E-64 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 SUPERFAMILY SSF51905 320 380 1.21E-59 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 SUPERFAMILY SSF51905 13 228 1.21E-59 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 Gene3D G3DSA:3.30.9.10 95 148 2.2E-27 T 17-03-2017 SHXM_RS40625 c367a31004d7f5832c7683425a162325 390 Gene3D G3DSA:3.30.9.10 228 317 2.2E-27 T 17-03-2017 SHXM_RS19175 30f785fc199d1138ac2b1ae0ad49cd76 240 SUPERFAMILY SSF56529 54 206 3.53E-7 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS19175 30f785fc199d1138ac2b1ae0ad49cd76 240 Gene3D G3DSA:3.90.850.10 104 203 9.6E-5 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS19175 30f785fc199d1138ac2b1ae0ad49cd76 240 Gene3D G3DSA:3.90.850.10 28 50 9.6E-5 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS19175 30f785fc199d1138ac2b1ae0ad49cd76 240 Pfam PF11010 Protein of unknown function (DUF2848) 36 230 4.7E-78 T 17-03-2017 IPR021269 Protein of unknown function DUF2848 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 Gene3D G3DSA:3.40.50.10090 408 525 2.5E-33 T 17-03-2017 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 Gene3D G3DSA:3.40.50.10090 278 400 5.5E-40 T 17-03-2017 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 SUPERFAMILY SSF53790 9 276 3.93E-43 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 SUPERFAMILY SSF69618 273 523 2.62E-64 T 17-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 13 228 1.0E-33 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 Pfam PF02602 Uroporphyrinogen-III synthase HemD 287 514 1.6E-62 T 17-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 17 31 - T 17-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 Gene3D G3DSA:3.40.1010.10 12 135 3.5E-28 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS30470 3403417bd3770bed75611d1819d4596c 554 Gene3D G3DSA:3.30.950.10 137 277 3.0E-30 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS32530 45e2c76029170ee824c172802e0fbe64 316 Gene3D G3DSA:3.40.50.1820 24 298 4.5E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32530 45e2c76029170ee824c172802e0fbe64 316 PRINTS PR00111 Alpha/beta hydrolase fold signature 114 127 3.2E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS32530 45e2c76029170ee824c172802e0fbe64 316 PRINTS PR00111 Alpha/beta hydrolase fold signature 67 82 3.2E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS32530 45e2c76029170ee824c172802e0fbe64 316 PRINTS PR00111 Alpha/beta hydrolase fold signature 242 256 3.2E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS32530 45e2c76029170ee824c172802e0fbe64 316 Pfam PF12697 Alpha/beta hydrolase family 44 289 3.0E-21 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS32530 45e2c76029170ee824c172802e0fbe64 316 SUPERFAMILY SSF53474 22 295 1.09E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41925 e5e0dad50746edfc037f6c5fe5d4e677 256 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 4 91 7.0E-17 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS41925 e5e0dad50746edfc037f6c5fe5d4e677 256 Gene3D G3DSA:3.40.50.720 4 198 2.2E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41925 e5e0dad50746edfc037f6c5fe5d4e677 256 SUPERFAMILY SSF51735 4 197 1.15E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 TIGRFAM TIGR01135 glmS: glutamine-fructose-6-phosphate transaminase (isomerizing) 2 610 1.5E-218 T 17-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Pfam PF13522 Glutamine amidotransferase domain 69 198 7.3E-21 T 17-03-2017 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Gene3D G3DSA:3.40.50.10490 250 447 2.0E-66 T 17-03-2017 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 SUPERFAMILY SSF56235 2 239 1.37E-62 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 SUPERFAMILY SSF53697 250 610 1.3E-94 T 17-03-2017 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Gene3D G3DSA:3.60.20.10 2 244 1.7E-70 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Pfam PF01380 SIS domain 300 422 9.0E-27 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Pfam PF01380 SIS domain 467 591 9.9E-17 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Gene3D G3DSA:3.40.50.10490 448 610 1.9E-55 T 17-03-2017 SHXM_RS22640 4fe658bc8b1230f7cca2938f0930bb25 610 Hamap MF_00164 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] [glmS]. 1 610 37.227 T 17-03-2017 IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising GO:0004360|GO:1901137 KEGG: 00250+2.6.1.16|KEGG: 00520+2.6.1.16|MetaCyc: PWY-6749|Reactome: R-HSA-446210 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 SUPERFAMILY SSF88659 181 259 9.16E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 Gene3D G3DSA:1.10.10.10 202 259 4.7E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 PRINTS PR00046 Major sigma-70 factor signature 213 225 8.1E-7 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 PRINTS PR00046 Major sigma-70 factor signature 66 79 8.1E-7 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 PRINTS PR00046 Major sigma-70 factor signature 230 245 8.1E-7 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 Pfam PF04545 Sigma-70, region 4 210 257 1.4E-17 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 Pfam PF04542 Sigma-70 region 2 43 111 9.3E-16 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 36 260 1.2E-83 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 Gene3D G3DSA:1.10.601.10 21 109 6.8E-18 T 17-03-2017 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 Gene3D G3DSA:1.10.10.10 111 165 3.9E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 SUPERFAMILY SSF88659 115 191 2.18E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 SUPERFAMILY SSF88946 19 111 7.59E-25 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 Pfam PF04539 Sigma-70 region 3 122 187 2.6E-7 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06825 d9e74896f7e755a6ef5a15c866d509a0 265 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 39 259 4.2E-31 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 Gene3D G3DSA:3.30.450.40 36 198 7.6E-32 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 Pfam PF07730 Histidine kinase 378 440 6.2E-12 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 SUPERFAMILY SSF55781 212 387 2.4E-24 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 SUPERFAMILY SSF55874 485 572 2.44E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 Pfam PF13185 GAF domain 53 191 1.4E-19 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 Pfam PF13185 GAF domain 223 361 1.3E-13 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 Gene3D G3DSA:3.30.565.10 487 573 3.0E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 SMART SM00065 54 200 5.0E-20 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 SMART SM00065 221 370 1.5E-13 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 Gene3D G3DSA:3.30.450.40 199 373 2.4E-26 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 SMART SM00387 484 573 3.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43300 913b05f58ca018786b0bfc22e77cd479 585 SUPERFAMILY SSF55781 36 216 7.63E-39 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01260 6e43392cbbf82d36413281e00cac2cd7 183 Pfam PF13549 ATP-grasp domain 40 170 1.1E-31 T 17-03-2017 SHXM_RS01260 6e43392cbbf82d36413281e00cac2cd7 183 Gene3D G3DSA:3.30.470.20 59 171 4.5E-5 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS01260 6e43392cbbf82d36413281e00cac2cd7 183 SUPERFAMILY SSF56059 59 173 6.45E-16 T 17-03-2017 SHXM_RS06110 92219ea9350782de2a66fa082f9d9950 337 SUPERFAMILY SSF53822 30 329 1.34E-52 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS06110 92219ea9350782de2a66fa082f9d9950 337 Gene3D G3DSA:3.40.50.2300 148 329 1.2E-31 T 17-03-2017 SHXM_RS06110 92219ea9350782de2a66fa082f9d9950 337 Gene3D G3DSA:3.40.50.2300 31 147 4.5E-30 T 17-03-2017 SHXM_RS06110 92219ea9350782de2a66fa082f9d9950 337 Pfam PF13407 Periplasmic binding protein domain 32 292 2.1E-42 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS07515 d8834c3f32cfb4dae311da28ef98d31c 465 Pfam PF00083 Sugar (and other) transporter 50 433 9.2E-62 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS07515 d8834c3f32cfb4dae311da28ef98d31c 465 Gene3D G3DSA:1.20.1250.20 246 427 2.7E-18 T 17-03-2017 SHXM_RS07515 d8834c3f32cfb4dae311da28ef98d31c 465 Gene3D G3DSA:1.20.1250.20 25 199 4.7E-30 T 17-03-2017 SHXM_RS07515 d8834c3f32cfb4dae311da28ef98d31c 465 SUPERFAMILY SSF103473 6 432 3.92E-79 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS07515 d8834c3f32cfb4dae311da28ef98d31c 465 ProSitePatterns PS00217 Sugar transport proteins signature 2. 114 139 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 SUPERFAMILY SSF88659 124 196 5.23E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 48 269 6.1E-35 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 SUPERFAMILY SSF88946 21 120 5.76E-33 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 Gene3D G3DSA:1.10.601.10 33 118 3.7E-27 T 17-03-2017 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 45 270 2.1E-88 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 Pfam PF04542 Sigma-70 region 2 51 120 5.7E-18 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 PIRSF PIRSF000770 23 274 1.8E-34 T 17-03-2017 IPR016263 RNA polymerase sporulation-specific sigma factor GO:0003677|GO:0006351|GO:0016987|GO:0030435 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 SUPERFAMILY SSF88659 194 271 9.72E-17 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 75 88 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 Gene3D G3DSA:1.10.10.10 119 174 2.0E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 PRINTS PR00046 Major sigma-70 factor signature 224 236 6.1E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 PRINTS PR00046 Major sigma-70 factor signature 256 267 6.1E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 PRINTS PR00046 Major sigma-70 factor signature 75 88 6.1E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 PRINTS PR00046 Major sigma-70 factor signature 241 256 6.1E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 Pfam PF04539 Sigma-70 region 3 131 189 1.6E-12 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 Gene3D G3DSA:1.10.10.10 217 270 5.8E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26680 f9d95c9445c570be730eaf41ddf3a823 274 Pfam PF04545 Sigma-70, region 4 222 269 3.8E-17 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 Gene3D G3DSA:3.50.50.60 120 196 9.7E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 Gene3D G3DSA:3.50.50.60 9 80 9.7E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 Gene3D G3DSA:3.50.50.60 284 363 9.7E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 SUPERFAMILY SSF51905 283 384 4.32E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 SUPERFAMILY SSF51905 9 191 4.32E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 Pfam PF01494 FAD binding domain 9 356 1.1E-46 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 298 313 2.2E-24 T 17-03-2017 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 9 31 2.2E-24 T 17-03-2017 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 313 329 2.2E-24 T 17-03-2017 SHXM_RS06680 c1e80df68123b88f0dd0acb67a0da5dc 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 170 185 2.2E-24 T 17-03-2017 SHXM_RS07705 57b517e80423e96e59e0de9abf297888 139 SMART SM00257 88 137 2.3E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS07705 57b517e80423e96e59e0de9abf297888 139 Gene3D G3DSA:3.10.350.10 86 136 5.9E-9 T 17-03-2017 IPR018392 LysM domain SHXM_RS07705 57b517e80423e96e59e0de9abf297888 139 SUPERFAMILY SSF54106 86 136 5.36E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS07705 57b517e80423e96e59e0de9abf297888 139 Pfam PF01476 LysM domain 89 135 6.8E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 58 66 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 Pfam PF13085 2Fe-2S iron-sulfur cluster binding domain 4 119 1.5E-23 T 17-03-2017 IPR025192 Succinate dehydogenase/fumarate reductase N-terminal GO:0009055|GO:0051536 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 158 169 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 SUPERFAMILY SSF46548 118 241 3.14E-24 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 Gene3D G3DSA:1.10.1060.10 110 242 2.2E-20 T 17-03-2017 SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 Gene3D G3DSA:3.10.20.30 1 109 1.4E-28 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 SUPERFAMILY SSF54292 1 115 7.9E-21 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS05160 9c0c7bd21e8dc7da2d15d1d8f79c149a 248 Pfam PF12838 4Fe-4S dicluster domain 158 227 1.5E-10 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS01485 65d4c87634036cc4e16a052b3912f3de 552 Gene3D G3DSA:3.40.190.10 499 549 1.7E-24 T 17-03-2017 SHXM_RS01485 65d4c87634036cc4e16a052b3912f3de 552 Gene3D G3DSA:3.40.190.10 225 419 1.7E-24 T 17-03-2017 SHXM_RS01485 65d4c87634036cc4e16a052b3912f3de 552 Gene3D G3DSA:3.40.190.10 124 217 2.1E-4 T 17-03-2017 SHXM_RS01485 65d4c87634036cc4e16a052b3912f3de 552 SUPERFAMILY SSF53850 95 549 2.63E-52 T 17-03-2017 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 SUPERFAMILY SSF52943 4 296 4.97E-80 T 17-03-2017 IPR023633 ATPase, F1 complex, gamma subunit domain Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 Gene3D G3DSA:1.10.287.80 245 291 6.3E-24 T 17-03-2017 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 Pfam PF00231 ATP synthase 6 296 1.7E-84 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 ProSitePatterns PS00153 ATP synthase gamma subunit signature. 282 295 - T 17-03-2017 IPR023632 ATPase, F1 complex, gamma subunit conserved site Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 TIGRFAM TIGR01146 ATPsyn_F1gamma: ATP synthase F1, gamma subunit 3 296 2.6E-91 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 Gene3D G3DSA:1.10.287.80 211 244 2.0E-26 T 17-03-2017 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 Gene3D G3DSA:1.10.287.80 20 61 2.0E-26 T 17-03-2017 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 Hamap MF_00815 ATP synthase gamma chain [atpG]. 2 296 33.035 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 Gene3D G3DSA:3.40.1380.10 64 197 3.1E-40 T 17-03-2017 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 PRINTS PR00126 ATP synthase gamma subunit signature 74 93 6.3E-30 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 PRINTS PR00126 ATP synthase gamma subunit signature 274 295 6.3E-30 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 PRINTS PR00126 ATP synthase gamma subunit signature 243 262 6.3E-30 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS35255 07b636f4dd87b9010cfbf0d39a34f5c8 304 PRINTS PR00126 ATP synthase gamma subunit signature 171 188 6.3E-30 T 17-03-2017 IPR000131 ATPase, F1 complex, gamma subunit GO:0015986|GO:0045261|GO:0046933|GO:0046961 Reactome: R-HSA-163210 SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 Gene3D G3DSA:3.30.300.30 407 506 8.8E-31 T 17-03-2017 SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 Pfam PF00501 AMP-binding enzyme 10 412 1.7E-111 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 Gene3D G3DSA:2.30.38.10 329 406 9.1E-26 T 17-03-2017 SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 ProSitePatterns PS00455 Putative AMP-binding domain signature. 163 174 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 Gene3D G3DSA:3.40.50.980 169 328 1.1E-45 T 17-03-2017 SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 Gene3D G3DSA:3.40.50.980 5 168 1.5E-44 T 17-03-2017 SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 Pfam PF13193 AMP-binding enzyme C-terminal domain 421 499 3.0E-18 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04385 239faa3a3b6493345ac1597450d3bd4b 514 SUPERFAMILY SSF56801 3 510 1.7E-161 T 17-03-2017 SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 SUPERFAMILY SSF90123 25 318 1.7E-13 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 SMART SM00382 398 592 9.5E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 Pfam PF00005 ABC transporter 390 546 3.1E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 ProSitePatterns PS00211 ABC transporters family signature. 515 529 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 SUPERFAMILY SSF52540 368 616 1.98E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 Gene3D G3DSA:3.40.50.300 372 610 1.5E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15415 6d2b508bcbbfabacdefff2355cdf896c 634 Gene3D G3DSA:1.20.1560.10 24 334 3.9E-7 T 17-03-2017 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 33 156 5.9E-12 T 17-03-2017 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 SUPERFAMILY SSF110942 528 643 4.32E-31 T 17-03-2017 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 Gene3D G3DSA:3.30.565.10 6 254 7.5E-76 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 Pfam PF00183 Hsp90 protein 227 648 1.9E-135 T 17-03-2017 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PIRSF PIRSF002583 2 648 2.1E-217 T 17-03-2017 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 ProSitePatterns PS00298 Heat shock hsp90 proteins family signature. 26 35 - T 17-03-2017 IPR019805 Heat shock protein Hsp90, conserved site GO:0005524|GO:0006457|GO:0006950|GO:0051082 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 SUPERFAMILY SSF55874 5 216 2.36E-60 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 94 111 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 76 93 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 27 49 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 123 145 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 196 214 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 173 190 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 PRINTS PR00775 90kDa heat shock protein signature 6 26 9.8E-55 T 17-03-2017 IPR020575 Heat shock protein Hsp90, N-terminal SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 SUPERFAMILY SSF54211 247 500 7.21E-93 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 Hamap MF_00505 Chaperone protein HtpG [htpG]. 3 645 30.023 T 17-03-2017 IPR001404 Heat shock protein Hsp90 family GO:0005524|GO:0006457|GO:0006950|GO:0051082 SHXM_RS03645 7963950fcd489cfacb9bb79b4ec895e1 648 SMART SM00387 28 185 9.9E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:3.30.200.20 13 136 2.9E-19 T 17-03-2017 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 519 533 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF56112 17 290 1.04E-58 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:1.25.40.10 304 357 1.3E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:1.25.40.10 779 827 1.3E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 879 960 6.5 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 1004 1050 0.59 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 493 532 1.9E-5 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 622 660 2.1E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 963 1001 0.16 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 666 706 0.14 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 830 876 18.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 450 490 3.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 1095 1133 1.8E-7 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00320 1053 1092 4.8E-8 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00028 313 346 8.4E-4 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00028 384 417 86.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:2.130.10.10 468 613 1.4E-27 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:2.130.10.10 614 732 1.6E-25 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:1.10.510.10 137 289 8.1E-33 T 17-03-2017 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 863 877 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF48452 313 352 6.65E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF48452 390 422 6.65E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 693 707 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Pfam PF00400 WD domain, G-beta repeat 469 490 0.021 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Pfam PF00400 WD domain, G-beta repeat 500 532 6.4E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Pfam PF00400 WD domain, G-beta repeat 636 660 3.6E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Pfam PF00400 WD domain, G-beta repeat 1096 1133 4.3E-4 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Pfam PF00400 WD domain, G-beta repeat 1055 1091 1.1E-5 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF50998 456 728 1.61E-48 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SMART SM00220 20 290 4.4E-35 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Gene3D G3DSA:2.130.10.10 850 1135 3.8E-58 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 PRINTS PR00320 G protein beta WD-40 repeat signature 519 533 1.9E-5 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 PRINTS PR00320 G protein beta WD-40 repeat signature 863 877 1.9E-5 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 PRINTS PR00320 G protein beta WD-40 repeat signature 1037 1051 1.9E-5 T 17-03-2017 IPR020472 G-protein beta WD-40 repeat SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 146 158 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 Pfam PF00069 Protein kinase domain 20 281 2.4E-34 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 26 49 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 1079 1093 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF50978 633 718 1.3E-61 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF50978 847 905 1.3E-61 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS40205 7ce1552fa94b228c3d654ed92a5f6e65 1141 SUPERFAMILY SSF50978 948 1130 1.3E-61 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS46445 16a82043c565397a7b22644988ec2fb7 385 Gene3D G3DSA:3.50.50.60 131 214 1.2E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46445 16a82043c565397a7b22644988ec2fb7 385 Gene3D G3DSA:3.50.50.60 2 70 1.2E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46445 16a82043c565397a7b22644988ec2fb7 385 Gene3D G3DSA:3.50.50.60 313 378 1.2E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46445 16a82043c565397a7b22644988ec2fb7 385 Pfam PF01266 FAD dependent oxidoreductase 2 349 1.6E-40 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS46445 16a82043c565397a7b22644988ec2fb7 385 SUPERFAMILY SSF51905 2 215 3.19E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46445 16a82043c565397a7b22644988ec2fb7 385 SUPERFAMILY SSF51905 313 361 3.19E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 SUPERFAMILY SSF53474 9 284 4.09E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 Gene3D G3DSA:3.40.50.1820 8 283 1.8E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 PRINTS PR00412 Epoxide hydrolase signature 58 73 2.2E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 PRINTS PR00412 Epoxide hydrolase signature 38 56 2.2E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 PRINTS PR00412 Epoxide hydrolase signature 116 129 2.2E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 PRINTS PR00412 Epoxide hydrolase signature 260 282 2.2E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS11735 e3f7bf7570169ec817847fff5644724a 289 Pfam PF00561 alpha/beta hydrolase fold 32 141 2.1E-22 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 SUPERFAMILY SSF51905 3 315 3.19E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 299 8.8E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 151 175 5.2E-15 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 278 296 5.2E-15 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 204 220 5.2E-15 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 109 117 5.2E-15 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 5 27 5.2E-15 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 Gene3D G3DSA:3.50.50.60 4 113 7.6E-21 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 Gene3D G3DSA:3.50.50.60 114 311 8.4E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 155 173 1.1E-14 T 17-03-2017 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 268 290 1.1E-14 T 17-03-2017 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 108 126 1.1E-14 T 17-03-2017 SHXM_RS49615 25045f7a5ed97bffc69e8955abde6f6c 413 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 1.1E-14 T 17-03-2017 SHXM_RS26855 096495084be514843f72bfa55b83e576 406 Pfam PF13177 DNA polymerase III, delta subunit 40 190 2.3E-35 T 17-03-2017 SHXM_RS26855 096495084be514843f72bfa55b83e576 406 Gene3D G3DSA:3.40.50.300 4 191 2.9E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26855 096495084be514843f72bfa55b83e576 406 SUPERFAMILY SSF52540 4 230 3.92E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26855 096495084be514843f72bfa55b83e576 406 Pfam PF09115 DNA polymerase III, delta subunit, C terminal 333 390 1.8E-4 T 17-03-2017 IPR015199 DNA polymerase III, delta subunit, C-terminal GO:0003677|GO:0003887|GO:0006260|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 SMART SM00354 5 75 9.1E-27 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 52 5.8E-18 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 7 17 3.3E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 17 27 3.3E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 Gene3D G3DSA:3.40.50.2300 176 333 2.6E-59 T 17-03-2017 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 Pfam PF13377 Periplasmic binding protein-like domain 177 333 2.6E-37 T 17-03-2017 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 SUPERFAMILY SSF47413 5 63 1.5E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 Gene3D G3DSA:1.10.260.40 6 60 6.6E-25 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 SUPERFAMILY SSF53822 80 333 1.76E-65 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS07080 8bf066ccb5075651ec6e9532f26e0bbf 334 Gene3D G3DSA:3.40.50.2300 61 175 3.6E-23 T 17-03-2017 SHXM_RS28840 8757de49e3b41b90f99873384cfc237c 339 Gene3D G3DSA:3.10.580.10 223 333 7.8E-13 T 17-03-2017 SHXM_RS28840 8757de49e3b41b90f99873384cfc237c 339 SUPERFAMILY SSF54631 205 335 7.45E-20 T 17-03-2017 SHXM_RS28840 8757de49e3b41b90f99873384cfc237c 339 Pfam PF00571 CBS domain 286 334 1.3E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS28840 8757de49e3b41b90f99873384cfc237c 339 Pfam PF01595 Domain of unknown function DUF21 10 199 5.7E-43 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 Pfam PF00196 Bacterial regulatory proteins, luxR family 133 187 1.5E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 Gene3D G3DSA:1.10.10.10 113 194 4.3E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 Gene3D G3DSA:3.40.50.2300 2 112 3.2E-7 T 17-03-2017 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 148 164 1.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 134 148 1.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 164 176 1.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 SUPERFAMILY SSF52172 5 120 1.23E-5 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 SMART SM00421 131 188 5.8E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19800 34768276ca56a6c655892fcd464a90ef 194 SUPERFAMILY SSF46894 123 193 3.4E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS19745 2a73b4481db470a3bab81fca6ba64d64 402 Pfam PF07730 Histidine kinase 183 249 8.4E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS19745 2a73b4481db470a3bab81fca6ba64d64 402 Gene3D G3DSA:3.30.565.10 254 391 2.0E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19745 2a73b4481db470a3bab81fca6ba64d64 402 SUPERFAMILY SSF55874 262 386 3.49E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29950 1c407f59d20add1c91b4a848c3d8c9c7 354 TIGRFAM TIGR00974 3a0107s02c: phosphate ABC transporter, permease protein PstA 80 346 6.0E-86 T 17-03-2017 IPR005672 Phosphate transport system permease protein PstA GO:0005315|GO:0005887|GO:0035435 SHXM_RS29950 1c407f59d20add1c91b4a848c3d8c9c7 354 Gene3D G3DSA:1.10.3720.10 79 348 1.6E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS29950 1c407f59d20add1c91b4a848c3d8c9c7 354 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 151 351 3.7E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS29950 1c407f59d20add1c91b4a848c3d8c9c7 354 SUPERFAMILY SSF161098 87 341 7.19E-43 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PIRSF PIRSF037495 4 477 4.1E-126 T 17-03-2017 IPR017224 Opine oxidase, subunit A/hydrogen cyanide synthase, subunit B GO:0016491|GO:0055114 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 Gene3D G3DSA:3.50.50.60 187 338 1.6E-16 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 Gene3D G3DSA:3.50.50.60 7 186 4.7E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 13 32 5.0E-16 T 17-03-2017 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 125 143 5.0E-16 T 17-03-2017 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 295 317 5.0E-16 T 17-03-2017 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 310 317 2.6E-9 T 17-03-2017 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 12 34 2.6E-9 T 17-03-2017 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 169 194 2.6E-9 T 17-03-2017 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 Pfam PF04324 BFD-like [2Fe-2S] binding domain 385 434 2.8E-5 T 17-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 11 320 2.9E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28740 802eacf53df1aadeb69a7cd32a827271 492 SUPERFAMILY SSF51905 11 357 6.11E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 Gene3D G3DSA:2.10.109.10 33 159 2.0E-20 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 Pfam PF10502 Signal peptidase, peptidase S26 118 158 1.0E-4 T 17-03-2017 IPR019533 Peptidase S26 SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 Pfam PF00717 Peptidase S24-like 35 107 5.8E-9 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 97 109 4.9E-10 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 29 45 4.9E-10 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 125 144 4.9E-10 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS46615 2cecc3cd1f328830d156fa27a1cb675e 174 SUPERFAMILY SSF51306 33 160 5.76E-21 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS22100 c377bf247f84f037ea25f6cff61ac4a2 347 Pfam PF13469 Sulfotransferase family 8 195 2.7E-12 T 17-03-2017 SHXM_RS22100 c377bf247f84f037ea25f6cff61ac4a2 347 Gene3D G3DSA:3.40.50.300 166 308 1.7E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22100 c377bf247f84f037ea25f6cff61ac4a2 347 Gene3D G3DSA:3.40.50.300 8 88 1.7E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22100 c377bf247f84f037ea25f6cff61ac4a2 347 SUPERFAMILY SSF52540 5 49 1.17E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22100 c377bf247f84f037ea25f6cff61ac4a2 347 SUPERFAMILY SSF52540 139 199 1.17E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22100 c377bf247f84f037ea25f6cff61ac4a2 347 SUPERFAMILY SSF52540 233 314 1.17E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14505 5fcb708bf40c11d2e80447b29de2a044 223 Pfam PF09335 SNARE associated Golgi protein 47 175 2.5E-11 T 17-03-2017 IPR032816 SNARE associated Golgi protein SHXM_RS02550 5d99077a290bc7ed87c1e87389bcb2b3 90 Gene3D G3DSA:3.90.226.10 19 89 5.1E-12 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS02550 5d99077a290bc7ed87c1e87389bcb2b3 90 Pfam PF00378 Enoyl-CoA hydratase/isomerase 26 85 1.4E-9 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS02550 5d99077a290bc7ed87c1e87389bcb2b3 90 SUPERFAMILY SSF52096 22 87 2.52E-12 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 SUPERFAMILY SSF52283 7 128 3.4E-10 T 17-03-2017 SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 31 329 6.4E-8 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 112 297 1.0E-42 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 Gene3D G3DSA:3.40.50.720 9 114 9.8E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 231 247 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 SUPERFAMILY SSF51735 102 297 2.54E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05950 2629c256ad8e30510e73d521a72fad7b 333 Gene3D G3DSA:3.40.50.720 115 301 7.9E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01450 c1f4a75f51e22d72875d3ba15f90be28 243 SUPERFAMILY SSF53335 9 221 2.94E-39 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01450 c1f4a75f51e22d72875d3ba15f90be28 243 Gene3D G3DSA:3.40.50.150 18 216 5.4E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01450 c1f4a75f51e22d72875d3ba15f90be28 243 Pfam PF01209 ubiE/COQ5 methyltransferase family 3 215 4.0E-18 T 17-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 SHXM_RS29935 da0d1b16252fa0a0b624542e86e263dd 206 SUPERFAMILY SSF109755 39 199 8.89E-5 T 17-03-2017 SHXM_RS29935 da0d1b16252fa0a0b624542e86e263dd 206 Pfam PF01865 Protein of unknown function DUF47 7 203 2.8E-30 T 17-03-2017 IPR018445 Putative phosphate transport regulator SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 Gene3D G3DSA:3.40.50.300 14 240 2.0E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 SUPERFAMILY SSF52540 15 237 2.97E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 Gene3D G3DSA:3.40.50.300 266 503 2.7E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 Pfam PF00005 ABC transporter 276 429 2.8E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 Pfam PF00005 ABC transporter 26 176 1.5E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 SMART SM00382 284 478 1.6E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 SMART SM00382 35 224 1.1E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 ProSitePatterns PS00211 ABC transporters family signature. 402 416 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS01015 b5b9661bf9f001bd7eb9d3fcc9ab0807 512 SUPERFAMILY SSF52540 273 489 5.06E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11935 198bf152755e4f138e54e54723eef41e 274 SUPERFAMILY SSF53335 36 242 2.89E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11935 198bf152755e4f138e54e54723eef41e 274 Pfam PF13649 Methyltransferase domain 50 145 1.6E-15 T 17-03-2017 SHXM_RS11935 198bf152755e4f138e54e54723eef41e 274 Gene3D G3DSA:3.40.50.150 43 230 1.5E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 SUPERFAMILY SSF48498 81 200 1.11E-14 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 Pfam PF16859 Bacterial transcriptional repressor C-terminal 78 195 2.1E-16 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 Gene3D G3DSA:1.10.10.60 10 57 2.3E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 SUPERFAMILY SSF46689 10 78 1.9E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 64 3.7E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 Gene3D G3DSA:1.10.357.10 60 201 4.7E-34 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 2.1E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35490 bdc3d3bb097e555da7e8e37661e07ed3 224 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 2.1E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 Pfam PF00425 chorismate binding enzyme 126 409 6.0E-37 T 17-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal SHXM_RS18750 756b0cad987605975616127d2a38451d 669 PRINTS PR00097 Anthranilate synthase component II signature 643 656 4.3E-9 T 17-03-2017 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 PRINTS PR00097 Anthranilate synthase component II signature 478 492 4.3E-9 T 17-03-2017 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 PRINTS PR00097 Anthranilate synthase component II signature 523 532 4.3E-9 T 17-03-2017 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 SUPERFAMILY SSF56322 61 418 2.35E-54 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 Gene3D G3DSA:3.40.50.880 478 665 1.2E-28 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS18750 756b0cad987605975616127d2a38451d 669 SUPERFAMILY SSF52317 478 666 9.41E-21 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS18750 756b0cad987605975616127d2a38451d 669 PRINTS PR00096 Glutamine amidotransferase superfamily signature 557 568 1.2E-9 T 17-03-2017 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 PRINTS PR00096 Glutamine amidotransferase superfamily signature 643 656 1.2E-9 T 17-03-2017 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 PRINTS PR00096 Glutamine amidotransferase superfamily signature 523 532 1.2E-9 T 17-03-2017 SHXM_RS18750 756b0cad987605975616127d2a38451d 669 Pfam PF00117 Glutamine amidotransferase class-I 480 661 1.4E-23 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS18750 756b0cad987605975616127d2a38451d 669 Gene3D G3DSA:3.60.120.10 105 419 4.0E-50 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS36380 f28e365cc7451fa1526071ecfaf1cfd4 252 SUPERFAMILY SSF69593 5 221 1.31E-38 T 17-03-2017 SHXM_RS36380 f28e365cc7451fa1526071ecfaf1cfd4 252 SMART SM00563 41 159 4.6E-33 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS36380 f28e365cc7451fa1526071ecfaf1cfd4 252 Gene3D G3DSA:3.40.1130.10 32 221 4.3E-17 T 17-03-2017 SHXM_RS36380 f28e365cc7451fa1526071ecfaf1cfd4 252 Pfam PF01553 Acyltransferase 29 155 3.4E-23 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Gene3D G3DSA:2.40.50.140 388 509 5.4E-33 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Pfam PF04675 DNA ligase N terminus 70 137 4.3E-5 T 17-03-2017 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Gene3D G3DSA:3.30.470.30 213 326 5.8E-29 T 17-03-2017 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Gene3D G3DSA:3.30.1490.70 337 381 4.3E-15 T 17-03-2017 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Gene3D G3DSA:3.30.1490.70 184 212 4.3E-15 T 17-03-2017 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 SUPERFAMILY SSF50249 387 510 2.91E-30 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 208 216 - T 17-03-2017 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Pfam PF04679 ATP dependent DNA ligase C terminal region 404 495 3.0E-13 T 17-03-2017 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 TIGRFAM TIGR00574 dnl1: DNA ligase I, ATP-dependent (dnl1) 71 508 1.3E-75 T 17-03-2017 IPR000977 DNA ligase, ATP-dependent GO:0003910|GO:0005524|GO:0006281|GO:0006310|GO:0071897 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 SUPERFAMILY SSF117018 5 200 8.24E-26 T 17-03-2017 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Gene3D G3DSA:1.10.3260.10 70 183 3.6E-17 T 17-03-2017 IPR012308 DNA ligase, ATP-dependent, N-terminal GO:0003677|GO:0003910|GO:0006281|GO:0006310 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 SUPERFAMILY SSF56091 180 385 1.53E-42 T 17-03-2017 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Pfam PF01068 ATP dependent DNA ligase domain 186 385 4.1E-42 T 17-03-2017 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 SHXM_RS28575 85697893a95417fe3725c636c4d8cd54 512 Hamap MF_00407 DNA ligase [lig]. 1 511 25.522 T 17-03-2017 IPR022865 DNA ligase, ATP-dependent, bacterial/archaeal GO:0003910 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 Gene3D G3DSA:3.50.50.60 284 323 3.7E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 Gene3D G3DSA:3.50.50.60 3 172 3.7E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 10 32 9.3E-36 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 318 336 9.3E-36 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 336 352 9.3E-36 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 300 316 9.3E-36 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 285 300 9.3E-36 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 161 176 9.3E-36 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 SUPERFAMILY SSF51905 9 182 1.12E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 SUPERFAMILY SSF51905 272 358 1.12E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 Pfam PF01494 FAD binding domain 9 349 2.5E-58 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 Gene3D G3DSA:3.30.9.10 333 360 2.1E-6 T 17-03-2017 SHXM_RS39730 924c125db14506f5d7e7f238301c14fb 500 Gene3D G3DSA:3.30.9.10 173 283 2.1E-6 T 17-03-2017 SHXM_RS25220 d47c72e9e70b5f682f94254e661dc74e 500 Gene3D G3DSA:3.40.309.10 263 461 3.6E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS25220 d47c72e9e70b5f682f94254e661dc74e 500 Pfam PF00171 Aldehyde dehydrogenase family 13 486 3.3E-162 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS25220 d47c72e9e70b5f682f94254e661dc74e 500 Gene3D G3DSA:3.40.605.10 8 262 2.7E-88 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS25220 d47c72e9e70b5f682f94254e661dc74e 500 SUPERFAMILY SSF53720 7 491 3.93E-155 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS25220 d47c72e9e70b5f682f94254e661dc74e 500 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 251 258 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS25220 d47c72e9e70b5f682f94254e661dc74e 500 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 284 295 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 SUPERFAMILY SSF54631 1 119 1.81E-34 T 17-03-2017 SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 Pfam PF04972 BON domain 121 187 8.8E-13 T 17-03-2017 IPR007055 BON domain SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 Gene3D G3DSA:3.20.20.70 2 120 1.9E-36 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 SMART SM00116 70 118 8.4E-14 T 17-03-2017 IPR000644 CBS domain SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 SMART SM00116 13 61 2.4E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 Pfam PF00571 CBS domain 63 117 5.0E-19 T 17-03-2017 IPR000644 CBS domain SHXM_RS07990 649a71e02755d14a03a79cff0af70a13 200 Pfam PF00571 CBS domain 7 56 1.5E-10 T 17-03-2017 IPR000644 CBS domain SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 310 414 3.7E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 SMART SM00388 203 261 3.4E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 Pfam PF00512 His Kinase A (phospho-acceptor) domain 205 261 3.0E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 SUPERFAMILY SSF47384 190 261 6.67E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 SMART SM00387 310 415 8.9E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 Pfam PF00672 HAMP domain 129 199 4.8E-11 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 SUPERFAMILY SSF55874 250 413 1.05E-25 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 Gene3D G3DSA:1.10.287.130 193 248 2.2E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 Gene3D G3DSA:3.30.565.10 249 413 4.5E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 SUPERFAMILY SSF158472 150 199 5.89E-6 T 17-03-2017 SHXM_RS07010 b1ee549033d345d00e6c20ee5c5646b3 422 SMART SM00304 148 202 3.6E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS34730 67395c1e4df86f916626a1941530b0e1 186 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 60 2.1E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34730 67395c1e4df86f916626a1941530b0e1 186 Gene3D G3DSA:1.10.357.10 4 185 9.6E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34730 67395c1e4df86f916626a1941530b0e1 186 SUPERFAMILY SSF46689 3 78 9.98E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS34730 67395c1e4df86f916626a1941530b0e1 186 SUPERFAMILY SSF48498 80 183 6.14E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS29300 8bc7a77764f1e3ce90d32b91741f5b13 341 SUPERFAMILY SSF111331 2 121 2.4E-7 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 130 200 3.4E-7 T 17-03-2017 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 305 383 6.4E-7 T 17-03-2017 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 SMART SM00191 48 106 0.26 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 SMART SM00191 361 419 0.0042 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 SMART SM00191 118 167 15.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 SMART SM00191 429 494 0.031 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 SMART SM00191 296 349 40.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 SUPERFAMILY SSF69318 55 460 7.59E-44 T 17-03-2017 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 Gene3D G3DSA:2.130.10.130 48 202 8.2E-20 T 17-03-2017 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 Gene3D G3DSA:2.130.10.130 239 460 2.4E-23 T 17-03-2017 SHXM_RS40195 19a1cdeb9984c5e9d7f9f25fe4bc90be 504 Pfam PF01839 FG-GAP repeat 59 89 2.3E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 Pfam PF00196 Bacterial regulatory proteins, luxR family 153 208 2.8E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 SUPERFAMILY SSF46894 138 213 9.18E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 Gene3D G3DSA:3.40.50.2300 1 153 9.1E-37 T 17-03-2017 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 SUPERFAMILY SSF52172 1 133 6.4E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 Gene3D G3DSA:1.10.10.10 154 213 1.0E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 Pfam PF00072 Response regulator receiver domain 4 115 2.4E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 ProSitePatterns PS00622 LuxR-type HTH domain signature. 168 195 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 168 184 3.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 154 168 3.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 184 196 3.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 SMART SM00448 2 115 1.8E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS14025 83623a6198e4eaa6d7bd57c9c7ff98c4 217 SMART SM00421 151 208 4.1E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12660 0762efad2bc80d783b10c8571b94d993 426 Gene3D G3DSA:3.40.190.10 157 321 2.4E-22 T 17-03-2017 SHXM_RS12660 0762efad2bc80d783b10c8571b94d993 426 Pfam PF01547 Bacterial extracellular solute-binding protein 56 333 3.2E-35 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS12660 0762efad2bc80d783b10c8571b94d993 426 SUPERFAMILY SSF53850 28 425 3.56E-62 T 17-03-2017 SHXM_RS12660 0762efad2bc80d783b10c8571b94d993 426 Gene3D G3DSA:3.40.190.10 47 156 2.6E-30 T 17-03-2017 SHXM_RS12660 0762efad2bc80d783b10c8571b94d993 426 Gene3D G3DSA:3.40.190.10 322 371 2.6E-30 T 17-03-2017 SHXM_RS17980 3485cda8d8dd7206dcf1e3adcb764dca 218 Gene3D G3DSA:3.60.15.10 18 216 1.8E-48 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS17980 3485cda8d8dd7206dcf1e3adcb764dca 218 Pfam PF00753 Metallo-beta-lactamase superfamily 29 189 2.1E-10 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS17980 3485cda8d8dd7206dcf1e3adcb764dca 218 SUPERFAMILY SSF56281 22 214 3.66E-44 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS17980 3485cda8d8dd7206dcf1e3adcb764dca 218 SMART SM00849 32 197 9.2E-29 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS04555 10103361b8e9ab5e06d2a5c94ecf8dc1 214 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 65 7.4E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04555 10103361b8e9ab5e06d2a5c94ecf8dc1 214 Gene3D G3DSA:1.10.357.10 4 207 2.5E-30 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04555 10103361b8e9ab5e06d2a5c94ecf8dc1 214 SUPERFAMILY SSF46689 6 86 2.87E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 SUPERFAMILY SSF55031 179 282 1.44E-20 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 Gene3D G3DSA:3.40.630.10 12 174 1.3E-59 T 17-03-2017 SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 Gene3D G3DSA:3.40.630.10 286 382 1.3E-59 T 17-03-2017 SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 Pfam PF07687 Peptidase dimerisation domain 179 266 1.5E-4 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 TIGRFAM TIGR01891 amidohydrolases: amidohydrolase 29 363 8.0E-56 T 17-03-2017 IPR017439 Amidohydrolase GO:0016787 SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 PIRSF PIRSF037226 7 388 4.7E-133 T 17-03-2017 IPR017144 Peptidase M20A, amidohydrolase, predicted SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 Pfam PF01546 Peptidase family M20/M25/M40 92 352 1.8E-7 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 Gene3D G3DSA:3.30.70.360 177 281 3.0E-23 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 SUPERFAMILY SSF53187 289 380 1.04E-56 T 17-03-2017 SHXM_RS44220 25c40f0ec38cdd992f1ec178a4fdd22d 391 SUPERFAMILY SSF53187 17 189 1.04E-56 T 17-03-2017 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 Gene3D G3DSA:1.25.40.10 195 286 1.0E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 Gene3D G3DSA:1.25.40.10 90 186 1.2E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SMART SM00530 13 67 1.7E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 Gene3D G3DSA:1.10.260.40 9 82 2.9E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 Pfam PF13432 Tetratricopeptide repeat 86 153 0.0027 T 17-03-2017 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SUPERFAMILY SSF48452 384 449 2.56E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SUPERFAMILY SSF48452 164 315 3.04E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SMART SM00028 240 273 140.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SMART SM00028 381 414 20.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SMART SM00028 119 152 290.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SMART SM00028 421 454 21.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 Pfam PF01381 Helix-turn-helix 16 67 9.3E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 Gene3D G3DSA:1.25.40.10 287 448 1.8E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25470 cb74df9ef751f652c64d35704e0b131d 468 SUPERFAMILY SSF47413 7 71 9.29E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 240 446 3.3E-30 T 17-03-2017 IPR008775 Phytanoyl-CoA dioxygenase SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 Gene3D G3DSA:1.10.10.60 73 131 3.7E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 SUPERFAMILY SSF51197 235 459 5.22E-44 T 17-03-2017 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 Pfam PF12833 Helix-turn-helix domain 100 173 9.1E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 Gene3D G3DSA:2.60.120.620 234 460 2.0E-45 T 17-03-2017 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 SUPERFAMILY SSF46689 129 173 7.62E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 Gene3D G3DSA:1.10.10.60 132 173 1.7E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 SUPERFAMILY SSF46689 76 126 4.57E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 130 172 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS50425 8ae31d026f84b30e154bb87c8bc9b9a2 477 SMART SM00342 93 176 1.9E-16 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 Gene3D G3DSA:3.40.710.10 261 473 8.8E-91 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 Gene3D G3DSA:3.40.710.10 511 661 8.8E-91 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 Gene3D G3DSA:3.90.1310.10 137 259 8.8E-32 T 17-03-2017 SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 SUPERFAMILY SSF56519 52 261 4.05E-37 T 17-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 TIGRFAM TIGR03423 pbp2_mrdA: penicillin-binding protein 2 16 661 4.3E-179 T 17-03-2017 IPR017790 Penicillin-binding protein 2 GO:0016020 SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 Pfam PF03717 Penicillin-binding Protein dimerisation domain 61 246 2.6E-39 T 17-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 SUPERFAMILY SSF56601 213 459 1.67E-83 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 SUPERFAMILY SSF56601 516 662 1.67E-83 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS21635 5336c9393640f289e794b64b01bc5879 714 Pfam PF00905 Penicillin binding protein transpeptidase domain 298 657 3.6E-85 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 SUPERFAMILY SSF48264 23 411 7.6E-92 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00385 P450 superfamily signature 284 295 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00385 P450 superfamily signature 351 360 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00385 P450 superfamily signature 360 371 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00385 P450 superfamily signature 247 264 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 353 362 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 148 164 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 351 360 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 101 112 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 202 224 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 302 329 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 330 345 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 165 180 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 284 295 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 PRINTS PR00359 B-class P450 signature 360 371 3.2E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 Pfam PF00067 Cytochrome P450 230 380 1.8E-25 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03245 5a5ad19d701cb769093fe3e92a77679b 411 Gene3D G3DSA:1.10.630.10 14 411 4.7E-118 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 Gene3D G3DSA:1.10.1040.10 165 294 8.6E-29 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 Gene3D G3DSA:3.40.50.720 1 164 3.5E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 SUPERFAMILY SSF51735 1 156 1.15E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 PIRSF PIRSF000103 1 293 1.2E-62 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 2 160 3.7E-42 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 166 287 2.6E-28 T 17-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 SUPERFAMILY SSF48179 164 294 1.7E-24 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS46320 b59e3ad8cc7cb91c6b5922436023f516 311 ProSitePatterns PS00895 3-hydroxyisobutyrate dehydrogenase signature. 5 18 - T 17-03-2017 IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS07135 ac27ec373b26b3f0d47ca94419bcb1fb 362 Gene3D G3DSA:3.40.50.720 6 225 2.2E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07135 ac27ec373b26b3f0d47ca94419bcb1fb 362 SUPERFAMILY SSF51735 301 327 7.75E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07135 ac27ec373b26b3f0d47ca94419bcb1fb 362 SUPERFAMILY SSF51735 1 269 7.75E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07135 ac27ec373b26b3f0d47ca94419bcb1fb 362 Pfam PF01370 NAD dependent epimerase/dehydratase family 9 244 1.4E-20 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS07135 ac27ec373b26b3f0d47ca94419bcb1fb 362 Gene3D G3DSA:3.90.25.10 226 326 2.5E-8 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF52151 2519 2625 7.06E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF52151 2339 2460 7.06E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00826 938 1101 1.8E-84 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF00550 Phosphopantetheine attachment site 1710 1776 2.5E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF00550 Phosphopantetheine attachment site 3274 3340 1.6E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF47336 3267 3351 3.01E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF52151 753 856 8.37E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF52151 573 694 8.37E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF47336 1705 1816 1.31E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 411 3.5E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2059 2176 6.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF51735 1221 1408 5.51E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.30.70.250 2465 2525 1.7E-7 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.30.70.250 699 759 1.2E-8 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF51735 2748 2968 3.18E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF14765 Polyketide synthase dehydratase 938 1214 6.4E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00823 Phosphopantetheine attachment site 1708 1780 4.2E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00823 Phosphopantetheine attachment site 3272 3344 5.3E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 539 1.6E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2179 2267 1.5E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM01294 1709 1776 2.2E-6 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM01294 3273 3340 4.6E-9 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.47.10 1803 2063 1.5E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.47.10 38 298 4.7E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.47.10 2065 2229 8.7E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.47.10 299 465 1.2E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF55048 699 760 5.62E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1964 1980 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2342 2635 2.2E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 576 870 8.6E-133 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:1.10.1200.10 3268 3344 1.0E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:1.10.1200.10 1706 1780 1.2E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF51735 1423 1642 5.49E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF55048 2465 2526 2.22E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2982 3162 2.9E-48 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1424 1604 4.0E-58 T 17-03-2017 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF53901 32 410 2.39E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF53901 1797 2174 2.49E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF08659 KR domain 1424 1602 1.2E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF08659 KR domain 2982 3161 3.0E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF08990 Erythronolide synthase docking 4 29 1.4E-8 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.366.10 760 874 1.9E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.366.10 2336 2460 2.6E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.366.10 2526 2634 2.6E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.366.10 570 694 1.9E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.50.720 2983 3200 2.0E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00825 Beta-ketoacyl synthase 38 464 7.2E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SMART SM00825 Beta-ketoacyl synthase 1803 2229 9.1E-223 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1735 1750 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Gene3D G3DSA:3.40.50.720 1422 1620 3.9E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 286 7.9E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1801 2051 7.0E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF00698 Acyl transferase domain 575 889 1.9E-61 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 Pfam PF00698 Acyl transferase domain 2341 2654 6.2E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 SUPERFAMILY SSF51735 2977 3231 4.11E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22175 52a3babea187a618d5082ace2615c031 3434 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3299 3314 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS27990 52b9354e118fe200d7109fbbc6ca5014 96 Hamap MF_00360 30S ribosomal protein S6 [rpsF]. 1 95 22.071 T 17-03-2017 IPR020814 Ribosomal protein S6, plastid/chloroplast GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS27990 52b9354e118fe200d7109fbbc6ca5014 96 ProSitePatterns PS01048 Ribosomal protein S6 signature. 44 53 - T 17-03-2017 IPR020815 Ribosomal protein S6, conserved site GO:0003735|GO:0005840|GO:0006412|GO:0019843 SHXM_RS27990 52b9354e118fe200d7109fbbc6ca5014 96 Pfam PF01250 Ribosomal protein S6 3 92 1.3E-28 T 17-03-2017 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27990 52b9354e118fe200d7109fbbc6ca5014 96 SUPERFAMILY SSF54995 1 94 6.93E-32 T 17-03-2017 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27990 52b9354e118fe200d7109fbbc6ca5014 96 Gene3D G3DSA:3.30.70.60 1 94 1.6E-34 T 17-03-2017 IPR014717 Translation elongation factor EF1B/ribosomal protein S6 SHXM_RS27990 52b9354e118fe200d7109fbbc6ca5014 96 TIGRFAM TIGR00166 S6: ribosomal protein bS6 1 92 5.6E-26 T 17-03-2017 IPR000529 Ribosomal protein S6 GO:0003735|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS46970 633e87db5719efe5cfd3a963ad7f8f40 324 SUPERFAMILY SSF161098 78 313 4.19E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46970 633e87db5719efe5cfd3a963ad7f8f40 324 Gene3D G3DSA:1.10.3720.10 84 323 1.3E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46970 633e87db5719efe5cfd3a963ad7f8f40 324 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 109 313 1.3E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 SUPERFAMILY SSF51445 15 371 1.72E-117 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 PIRSF PIRSF001084 8 671 2.1E-255 T 17-03-2017 IPR003476 Glycoside hydrolase, family 42 GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 Pfam PF02449 Beta-galactosidase 20 389 5.4E-149 T 17-03-2017 IPR013529 Glycoside hydrolase, family 42, N-terminal GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 Gene3D G3DSA:3.20.20.80 17 393 4.4E-133 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 SUPERFAMILY SSF52317 398 599 1.39E-46 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 Gene3D G3DSA:3.40.50.880 399 603 2.9E-60 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 Pfam PF08533 Beta-galactosidase C-terminal domain 609 669 4.5E-13 T 17-03-2017 IPR013739 Beta-galactosidase C-terminal GO:0004565|GO:0006012 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS13990 7dcf9d3dd8ed52bd6d019b5e3ed9a559 687 Pfam PF08532 Beta-galactosidase trimerisation domain 400 594 3.4E-57 T 17-03-2017 IPR013738 Beta-galactosidase trimerisation GO:0004565|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 SMART SM00382 30 213 1.5E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 SMART SM00382 315 491 1.9E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 Gene3D G3DSA:3.40.50.300 289 528 2.8E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 SUPERFAMILY SSF52540 5 208 4.04E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 Pfam PF12848 ABC transporter 198 254 1.5E-7 T 17-03-2017 IPR032781 ABC-transporter extension domain SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 SUPERFAMILY SSF52540 281 490 3.23E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 Pfam PF00005 ABC transporter 21 159 3.3E-23 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 Pfam PF00005 ABC transporter 306 447 7.2E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 ProSitePatterns PS00211 ABC transporters family signature. 419 433 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS32690 9f4ba56e2df9bae5b96ab41b6bdf09f6 605 Gene3D G3DSA:3.40.50.300 7 251 6.2E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23670 3b88157512888fb839902976fa7606ac 445 SUPERFAMILY SSF53850 50 440 5.93E-77 T 17-03-2017 SHXM_RS23670 3b88157512888fb839902976fa7606ac 445 Gene3D G3DSA:3.40.190.10 62 182 1.2E-19 T 17-03-2017 SHXM_RS23670 3b88157512888fb839902976fa7606ac 445 Gene3D G3DSA:3.40.190.10 183 374 9.9E-43 T 17-03-2017 SHXM_RS23670 3b88157512888fb839902976fa7606ac 445 Pfam PF13416 Bacterial extracellular solute-binding protein 71 384 4.5E-36 T 17-03-2017 SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 Gene3D G3DSA:3.40.50.720 3 261 1.4E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 189 206 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 224 244 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 187 3.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 SUPERFAMILY SSF51735 6 261 1.25E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23095 7ef0064ce6d7555561b74f3c0dd576f8 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 259 2.6E-43 T 17-03-2017 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 SUPERFAMILY SSF52833 153 314 2.78E-21 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 Gene3D G3DSA:3.40.30.10 154 314 5.6E-16 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 SUPERFAMILY SSF46955 1 112 3.55E-24 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 Pfam PF13411 MerR HTH family regulatory protein 1 61 8.0E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 Gene3D G3DSA:1.10.1660.10 1 112 1.8E-28 T 17-03-2017 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 Pfam PF08534 Redoxin 154 307 3.6E-18 T 17-03-2017 IPR013740 Redoxin GO:0016491 Reactome: R-HSA-3299685|Reactome: R-HSA-5628897 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 SMART SM00422 1 69 7.3E-24 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 6.1E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 6.1E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS11795 ce34e5130577d4dc85c73563a0c87af6 318 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 6.1E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS35925 bab6b98fa75eeeb0bacd502f10159567 671 Pfam PF13367 Protease prsW family 24 249 1.3E-11 T 17-03-2017 IPR026898 Protease PrsW GO:0008233 SHXM_RS41830 0e6202f5bd2a2d8c0ae153020f34a7c3 383 ProSitePatterns PS01095 Chitinases family 18 active site. 161 169 - T 17-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS41830 0e6202f5bd2a2d8c0ae153020f34a7c3 383 Pfam PF00704 Glycosyl hydrolases family 18 51 366 1.3E-24 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS41830 0e6202f5bd2a2d8c0ae153020f34a7c3 383 SUPERFAMILY SSF51445 49 373 2.55E-53 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS41830 0e6202f5bd2a2d8c0ae153020f34a7c3 383 Gene3D G3DSA:3.20.20.80 45 369 9.4E-62 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS41830 0e6202f5bd2a2d8c0ae153020f34a7c3 383 SMART SM00636 49 366 1.5E-6 T 17-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 SHXM_RS18475 efff55506b83b285ca9f21c19398f2c6 333 Gene3D G3DSA:3.40.30.10 146 331 8.8E-20 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18475 efff55506b83b285ca9f21c19398f2c6 333 Pfam PF13462 Thioredoxin 144 327 8.7E-33 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18475 efff55506b83b285ca9f21c19398f2c6 333 SUPERFAMILY SSF52833 143 311 2.56E-16 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS21195 77235ebc2c994ae75f2ef46f57041787 472 SUPERFAMILY SSF55874 335 448 1.01E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21195 77235ebc2c994ae75f2ef46f57041787 472 Gene3D G3DSA:3.30.565.10 328 399 1.7E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21195 77235ebc2c994ae75f2ef46f57041787 472 Pfam PF07730 Histidine kinase 233 302 8.5E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS17975 ab1243c0eee50b937a4b1340ec7dfb2e 274 SUPERFAMILY SSF109854 32 184 4.88E-38 T 17-03-2017 SHXM_RS17975 ab1243c0eee50b937a4b1340ec7dfb2e 274 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 43 179 1.9E-24 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS17975 ab1243c0eee50b937a4b1340ec7dfb2e 274 SUPERFAMILY SSF55718 188 272 1.15E-10 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS17975 ab1243c0eee50b937a4b1340ec7dfb2e 274 Gene3D G3DSA:1.20.120.450 42 152 1.8E-9 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS17975 ab1243c0eee50b937a4b1340ec7dfb2e 274 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 42 254 8.0E-33 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 TIGRFAM TIGR02325 C_P_lyase_phnF: phosphonate metabolism transcriptional regulator PhnF 7 239 2.7E-59 T 17-03-2017 IPR012702 Phosphonate C-P lyase system, transcriptional regulator PhnF SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 SUPERFAMILY SSF64288 64 241 1.46E-26 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 1.3E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 1.3E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 Gene3D G3DSA:3.40.1410.10 72 241 1.5E-25 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 Pfam PF07702 UTRA domain 113 235 1.1E-17 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 Gene3D G3DSA:1.10.10.10 14 71 3.6E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 SMART SM00866 96 236 6.5E-15 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 76 1.0E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 SMART SM00345 17 76 1.1E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49845 ef2346f202687b32d0d911a64f271448 250 SUPERFAMILY SSF46785 9 87 5.97E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 149 164 1.6E-23 T 17-03-2017 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 1.6E-23 T 17-03-2017 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 292 308 1.6E-23 T 17-03-2017 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 326 342 1.6E-23 T 17-03-2017 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 277 292 1.6E-23 T 17-03-2017 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 SUPERFAMILY SSF51905 4 170 1.17E-57 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 SUPERFAMILY SSF51905 264 370 1.17E-57 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 Gene3D G3DSA:3.50.50.60 4 175 8.5E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 Gene3D G3DSA:3.50.50.60 265 348 8.5E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06135 bb12cc8aee0fa3c91833a14ee46a338f 405 Pfam PF01494 FAD binding domain 7 341 6.8E-27 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 TIGRFAM TIGR00952 S15_bact: ribosomal protein uS15 6 89 2.2E-38 T 17-03-2017 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 ProDom PD157043 RIBOSOMAL S15 RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 30S CHLOROPLAST S15 MITOCHONDRIAL TYPE 11 88 2.0E-24 T 17-03-2017 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 SMART SM01387 8 88 1.5E-52 T 17-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 Hamap MF_01343_B 30S ribosomal protein S15 [rpsO]. 3 89 22.443 T 17-03-2017 IPR005290 Ribosomal protein S15, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 ProSitePatterns PS00362 Ribosomal protein S15 signature. 39 69 - T 17-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 Pfam PF00312 Ribosomal protein S15 8 88 2.4E-37 T 17-03-2017 IPR000589 Ribosomal protein S15 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 SUPERFAMILY SSF47060 3 89 2.09E-35 T 17-03-2017 IPR009068 S15/NS1, RNA-binding SHXM_RS37065 68a74aa0132cf801752b172f3b028456 95 Gene3D G3DSA:1.10.287.10 3 89 1.3E-39 T 17-03-2017 IPR009068 S15/NS1, RNA-binding SHXM_RS34435 f9a5e7c2d52d475b2502af0f5c3a8211 335 Pfam PF03193 Protein of unknown function, DUF258 95 270 1.2E-45 T 17-03-2017 IPR010914 RsgA type GTPase domain GO:0003924|GO:0005525 SHXM_RS34435 f9a5e7c2d52d475b2502af0f5c3a8211 335 Gene3D G3DSA:3.40.50.300 113 270 3.3E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34435 f9a5e7c2d52d475b2502af0f5c3a8211 335 TIGRFAM TIGR00157 TIGR00157: ribosome small subunit-dependent GTPase A 70 324 2.6E-44 T 17-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SHXM_RS34435 f9a5e7c2d52d475b2502af0f5c3a8211 335 Gene3D G3DSA:1.10.40.50 271 332 3.8E-13 T 17-03-2017 SHXM_RS34435 f9a5e7c2d52d475b2502af0f5c3a8211 335 SUPERFAMILY SSF52540 113 330 1.44E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34435 f9a5e7c2d52d475b2502af0f5c3a8211 335 Hamap MF_01820 Putative ribosome biogenesis GTPase RsgA [rsgA]. 36 333 27.111 T 17-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SHXM_RS00390 5a0f2a3a566a16c58f4c171340de20f7 234 SMART SM00091 6 72 8.5E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS00390 5a0f2a3a566a16c58f4c171340de20f7 234 Gene3D G3DSA:3.30.450.20 16 110 5.4E-18 T 17-03-2017 SHXM_RS00390 5a0f2a3a566a16c58f4c171340de20f7 234 Pfam PF08448 PAS fold 16 113 2.2E-11 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS00390 5a0f2a3a566a16c58f4c171340de20f7 234 SUPERFAMILY SSF55785 17 117 1.01E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS00390 5a0f2a3a566a16c58f4c171340de20f7 234 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 17 116 1.4E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS49950 84752dd9b499afeda44842221eeb65cc 147 Pfam PF12900 Pyridoxamine 5'-phosphate oxidase 18 138 5.2E-23 T 17-03-2017 IPR024747 Pyridoxamine 5'-phosphate oxidase-related SHXM_RS49950 84752dd9b499afeda44842221eeb65cc 147 SUPERFAMILY SSF50475 14 139 5.38E-18 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS49950 84752dd9b499afeda44842221eeb65cc 147 Gene3D G3DSA:2.30.110.10 13 141 5.6E-33 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 Gene3D G3DSA:3.30.200.20 4 82 2.0E-24 T 17-03-2017 SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 SMART SM00220 12 271 1.8E-60 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 18 41 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 135 147 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 Pfam PF00069 Protein kinase domain 12 261 6.3E-46 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 SUPERFAMILY SSF56112 8 355 1.35E-71 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS25395 4d553c8574cbc1d15429a663db23e3b4 623 Gene3D G3DSA:1.10.510.10 83 269 1.3E-45 T 17-03-2017 SHXM_RS15105 38cab30fbcb1482e1b89995f9a00ca5a 103 SUPERFAMILY SSF52242 23 85 4.45E-20 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15105 38cab30fbcb1482e1b89995f9a00ca5a 103 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 23 85 2.5E-20 T 17-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS15105 38cab30fbcb1482e1b89995f9a00ca5a 103 Pfam PF02310 B12 binding domain 23 83 8.0E-9 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15105 38cab30fbcb1482e1b89995f9a00ca5a 103 Gene3D G3DSA:3.40.50.280 23 85 9.2E-21 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 Gene3D G3DSA:1.10.10.60 262 309 1.6E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 Pfam PF12852 Cupin 2 191 2.6E-51 T 17-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 261 303 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 SMART SM00342 224 307 7.7E-28 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 Gene3D G3DSA:1.10.10.60 206 261 9.5E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 SUPERFAMILY SSF46689 207 258 4.48E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 SUPERFAMILY SSF46689 260 309 5.38E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16270 d5c6b86addf87457847f22828113e0b3 321 Pfam PF12833 Helix-turn-helix domain 230 308 9.9E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 Gene3D G3DSA:1.20.1250.20 30 215 8.8E-33 T 17-03-2017 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 123 143 1.2E-6 T 17-03-2017 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 153 177 1.2E-6 T 17-03-2017 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 PRINTS PR01036 Tetracycline resistance protein TetB signature 33 57 1.2E-6 T 17-03-2017 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 Pfam PF07690 Major Facilitator Superfamily 34 433 2.6E-55 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 30 439 1.6E-76 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 SUPERFAMILY SSF103473 270 442 2.35E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 SUPERFAMILY SSF103473 509 536 2.35E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 SUPERFAMILY SSF103473 8 221 2.35E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 Gene3D G3DSA:1.20.1250.20 514 535 1.3E-22 T 17-03-2017 SHXM_RS05750 fe40ae387dbdc6dac4f833b6dffdbfba 541 Gene3D G3DSA:1.20.1250.20 287 448 1.3E-22 T 17-03-2017 SHXM_RS10110 5de0528a23d4c6a6f763cc753da1ae27 448 Pfam PF00437 Type II/IV secretion system protein 98 376 9.7E-49 T 17-03-2017 IPR001482 Type II secretion system protein E GO:0005524|GO:0006810 SHXM_RS10110 5de0528a23d4c6a6f763cc753da1ae27 448 Gene3D G3DSA:3.30.450.90 93 191 6.0E-15 T 17-03-2017 SHXM_RS10110 5de0528a23d4c6a6f763cc753da1ae27 448 Gene3D G3DSA:3.40.50.300 198 413 5.1E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10110 5de0528a23d4c6a6f763cc753da1ae27 448 SUPERFAMILY SSF52540 86 351 6.34E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Pfam PF03143 Elongation factor Tu C-terminal domain 298 389 8.0E-21 T 17-03-2017 IPR004160 Translation elongation factor EFTu/EF1A, C-terminal SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Gene3D G3DSA:3.40.50.300 7 210 1.3E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 SUPERFAMILY SSF52540 6 218 7.89E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Pfam PF03144 Elongation factor Tu domain 2 225 291 1.4E-11 T 17-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Hamap MF_00118_B Elongation factor Tu [tuf]. 1 391 52.398 T 17-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Gene3D G3DSA:2.40.30.10 211 296 1.9E-29 T 17-03-2017 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 SUPERFAMILY SSF50465 301 391 8.63E-26 T 17-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 PRINTS PR00315 GTP-binding elongation factor signature 59 67 4.1E-23 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 PRINTS PR00315 GTP-binding elongation factor signature 132 141 4.1E-23 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 PRINTS PR00315 GTP-binding elongation factor signature 79 89 4.1E-23 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 PRINTS PR00315 GTP-binding elongation factor signature 14 27 4.1E-23 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 PRINTS PR00315 GTP-binding elongation factor signature 95 106 4.1E-23 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Gene3D G3DSA:2.40.30.10 300 389 6.7E-31 T 17-03-2017 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 14 148 2.1E-12 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 52 67 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 Pfam PF00009 Elongation factor Tu GTP binding domain 10 201 4.4E-53 T 17-03-2017 SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 SUPERFAMILY SSF50447 205 299 2.55E-25 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS10470 62177b1821004c21f948324a56c94deb 393 TIGRFAM TIGR00485 EF-Tu: translation elongation factor Tu 1 390 5.2E-167 T 17-03-2017 IPR004541 Translation elongation factor EFTu/EF1A, bacterial/organelle GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS38660 200dc5cd1afa06713855dcc9d4a3c1fc 282 SMART SM00530 16 71 0.0081 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS38660 200dc5cd1afa06713855dcc9d4a3c1fc 282 SUPERFAMILY SSF47413 9 64 2.51E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38660 200dc5cd1afa06713855dcc9d4a3c1fc 282 Gene3D G3DSA:1.10.260.40 4 64 2.6E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38660 200dc5cd1afa06713855dcc9d4a3c1fc 282 Pfam PF13560 Helix-turn-helix domain 12 74 1.1E-7 T 17-03-2017 SHXM_RS47550 d9189038c8a43c46ed0b18a95e219a6c 289 Pfam PF13560 Helix-turn-helix domain 9 88 4.5E-16 T 17-03-2017 SHXM_RS47550 d9189038c8a43c46ed0b18a95e219a6c 289 Gene3D G3DSA:1.10.260.40 6 84 2.4E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47550 d9189038c8a43c46ed0b18a95e219a6c 289 SUPERFAMILY SSF47413 34 83 5.36E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47550 d9189038c8a43c46ed0b18a95e219a6c 289 SMART SM00530 13 85 2.6E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 SUPERFAMILY SSF53067 4 182 4.7E-61 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 382 401 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 31 43 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 327 343 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 195 205 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 3 16 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 136 156 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 463 479 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 359 379 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 PRINTS PR00301 70kDa heat shock protein signature 54 62 4.0E-79 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:2.60.34.10 384 526 2.9E-65 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:3.30.30.30 53 104 3.8E-18 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Hamap MF_00332 Chaperone protein DnaK [dnaK]. 1 642 35.665 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 SUPERFAMILY SSF100920 378 534 4.19E-57 T 17-03-2017 IPR029047 Heat shock protein 70kD, peptide-binding domain Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 TIGRFAM TIGR02350 prok_dnaK: chaperone protein DnaK 3 596 3.5E-285 T 17-03-2017 IPR012725 Chaperone DnaK GO:0005524|GO:0006457|GO:0051082 Reactome: R-HSA-1268020|Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:3.90.640.10 223 308 2.0E-28 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Pfam PF00012 Hsp70 protein 4 591 1.7E-240 T 17-03-2017 IPR013126 Heat shock protein 70 family Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 SUPERFAMILY SSF53067 184 376 3.02E-64 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:3.30.420.40 117 189 8.0E-63 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:3.30.420.40 4 52 8.0E-63 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 ProSitePatterns PS00297 Heat shock hsp70 proteins family signature 1. 7 14 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:3.30.420.40 312 354 3.2E-34 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:3.30.420.40 190 222 3.2E-34 T 17-03-2017 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 ProSitePatterns PS00329 Heat shock hsp70 proteins family signature 2. 189 202 - T 17-03-2017 IPR018181 Heat shock protein 70, conserved site Reactome: R-HSA-3371453 SHXM_RS19600 bb1f551060190508953d699cb77074b0 642 Gene3D G3DSA:1.20.1270.10 527 594 8.3E-16 T 17-03-2017 IPR029048 Heat shock protein 70kD, C-terminal domain Reactome: R-HSA-3371453 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 Pfam PF00196 Bacterial regulatory proteins, luxR family 153 208 4.7E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 Gene3D G3DSA:1.10.10.10 158 214 1.4E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 SMART SM00421 151 208 3.6E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 SUPERFAMILY SSF52172 15 141 6.69E-30 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 SUPERFAMILY SSF46894 144 214 3.74E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 Gene3D G3DSA:3.40.50.2300 14 157 6.9E-35 T 17-03-2017 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 SMART SM00448 15 128 1.5E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 Pfam PF00072 Response regulator receiver domain 18 128 6.5E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 168 184 2.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 154 168 2.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29365 4feff790fadaca489a46fb5b3e3a02d6 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 184 196 2.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS06845 c6c8d061ae9e6cce1246dc93c3098926 143 TIGRFAM TIGR03668 Rv0121_F420: PPOX class probable F420-dependent enzyme, Rv0121 family 7 141 1.5E-48 T 17-03-2017 IPR019967 F420-dependent enzyme, PPOX class, family Rv0121, probable SHXM_RS06845 c6c8d061ae9e6cce1246dc93c3098926 143 SUPERFAMILY SSF50475 2 141 2.06E-25 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS06845 c6c8d061ae9e6cce1246dc93c3098926 143 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 7 98 2.8E-13 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS06845 c6c8d061ae9e6cce1246dc93c3098926 143 Gene3D G3DSA:2.30.110.10 5 141 1.8E-33 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS38320 b810091ceb2f2eb738308e2be33117bd 438 Gene3D G3DSA:3.20.20.370 97 282 6.7E-6 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS38320 b810091ceb2f2eb738308e2be33117bd 438 Gene3D G3DSA:3.20.20.370 333 408 6.7E-6 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS38320 b810091ceb2f2eb738308e2be33117bd 438 SUPERFAMILY SSF88713 183 412 9.45E-22 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS38320 b810091ceb2f2eb738308e2be33117bd 438 SUPERFAMILY SSF88713 112 153 9.45E-22 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS06555 3129d4364fb0dbd51b0a9b7679667cc9 219 Pfam PF02567 Phenazine biosynthesis-like protein 17 82 2.0E-10 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS06555 3129d4364fb0dbd51b0a9b7679667cc9 219 Gene3D G3DSA:3.10.310.10 126 190 1.4E-6 T 17-03-2017 SHXM_RS06555 3129d4364fb0dbd51b0a9b7679667cc9 219 SUPERFAMILY SSF54506 5 212 5.89E-26 T 17-03-2017 SHXM_RS06555 3129d4364fb0dbd51b0a9b7679667cc9 219 Gene3D G3DSA:3.10.310.10 5 82 4.3E-16 T 17-03-2017 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 Pfam PF12831 FAD dependent oxidoreductase 15 163 3.4E-7 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 SUPERFAMILY SSF51905 271 364 2.52E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 SUPERFAMILY SSF51905 14 182 2.52E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 TIGRFAM TIGR02032 GG-red-SF: geranylgeranyl reductase family 14 309 2.7E-80 T 17-03-2017 IPR011777 Geranylgeranyl reductase family GO:0016628|GO:0055114 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 155 170 1.6E-12 T 17-03-2017 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 15 37 1.6E-12 T 17-03-2017 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 274 289 1.6E-12 T 17-03-2017 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 Gene3D G3DSA:3.50.50.60 11 167 5.7E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43205 165a468e3fe46eadc16c2e48d9840405 401 Gene3D G3DSA:3.30.9.10 168 318 4.5E-27 T 17-03-2017 SHXM_RS28095 ce8b7bfa894cc4e64757c040a0164afd 169 Gene3D G3DSA:3.30.1370.50 102 168 7.5E-23 T 17-03-2017 IPR001374 R3H domain GO:0003676 SHXM_RS28095 ce8b7bfa894cc4e64757c040a0164afd 169 Gene3D G3DSA:3.30.300.120 19 101 1.6E-21 T 17-03-2017 SHXM_RS28095 ce8b7bfa894cc4e64757c040a0164afd 169 SMART SM00393 91 169 9.8E-25 T 17-03-2017 IPR001374 R3H domain GO:0003676 SHXM_RS28095 ce8b7bfa894cc4e64757c040a0164afd 169 Pfam PF01424 R3H domain 112 166 4.5E-14 T 17-03-2017 IPR001374 R3H domain GO:0003676 SHXM_RS28095 ce8b7bfa894cc4e64757c040a0164afd 169 SUPERFAMILY SSF82708 125 168 1.35E-10 T 17-03-2017 IPR001374 R3H domain GO:0003676 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 ProSitePatterns PS00117 Galactose-1-phosphate uridyl transferase family 1 active site signature. 154 171 - T 17-03-2017 IPR019779 Galactose-1-phosphate uridyl transferase, class I His-active site GO:0006012|GO:0008108|GO:0008270 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 Pfam PF01087 Galactose-1-phosphate uridyl transferase, N-terminal domain 103 178 1.5E-26 T 17-03-2017 IPR005849 Galactose-1-phosphate uridyl transferase, N-terminal GO:0006012|GO:0008108 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 SUPERFAMILY SSF54197 38 179 1.87E-46 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 Gene3D G3DSA:3.30.428.10 64 178 2.7E-33 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 SUPERFAMILY SSF54197 182 345 1.53E-36 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 TIGRFAM TIGR00209 galT_1: galactose-1-phosphate uridylyltransferase 104 345 5.8E-41 T 17-03-2017 IPR001937 Galactose-1-phosphate uridyl transferase, class I GO:0006012|GO:0008108|GO:0008270 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 PIRSF PIRSF000808 34 347 9.5E-105 T 17-03-2017 IPR001937 Galactose-1-phosphate uridyl transferase, class I GO:0006012|GO:0008108|GO:0008270 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 Pfam PF02744 Galactose-1-phosphate uridyl transferase, C-terminal domain 197 342 7.3E-15 T 17-03-2017 IPR005850 Galactose-1-phosphate uridyl transferase, C-terminal GO:0006012|GO:0008108 KEGG: 00052+2.7.7.12|KEGG: 00520+2.7.7.12|MetaCyc: PWY-6317|MetaCyc: PWY-6527|Reactome: R-HSA-5609978|Reactome: R-HSA-70370 SHXM_RS32715 fca23189628b5f6c31ae167a0a6bdb16 347 Gene3D G3DSA:3.30.428.10 180 345 4.9E-50 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2 178 0.0037 T 17-03-2017 SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 7.7E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 74 85 7.7E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 121 137 7.7E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 166 7.7E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 185 7.7E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 Gene3D G3DSA:3.40.50.720 2 246 2.5E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 SUPERFAMILY SSF51735 1 244 6.24E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 134 162 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS16140 d29703546044d50a4231ccbfa7b72907 282 Pfam PF00106 short chain dehydrogenase 2 187 2.5E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15965 2c6895e706b3bc133f507f8559322d84 531 PIRSF PIRSF002741 9 521 9.4E-55 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS15965 2c6895e706b3bc133f507f8559322d84 531 Gene3D G3DSA:3.10.105.10 284 497 4.6E-40 T 17-03-2017 SHXM_RS15965 2c6895e706b3bc133f507f8559322d84 531 Gene3D G3DSA:3.90.76.10 49 204 2.8E-27 T 17-03-2017 SHXM_RS15965 2c6895e706b3bc133f507f8559322d84 531 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 80 446 9.3E-62 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS15965 2c6895e706b3bc133f507f8559322d84 531 SUPERFAMILY SSF53850 32 525 3.67E-88 T 17-03-2017 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 Pfam PF13288 DXP reductoisomerase C-terminal domain 284 402 5.0E-32 T 17-03-2017 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 SUPERFAMILY SSF51735 22 172 8.67E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 Pfam PF02670 1-deoxy-D-xylulose 5-phosphate reductoisomerase 24 156 9.3E-38 T 17-03-2017 IPR013512 1-deoxy-D-xylulose 5-phosphate reductoisomerase, N-terminal GO:0055114|GO:0070402 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 Pfam PF08436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal 168 251 2.2E-36 T 17-03-2017 IPR013644 1-deoxy-D-xylulose 5-phosphate reductoisomerase, C-terminal GO:0005515 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 SUPERFAMILY SSF69055 314 408 2.22E-25 T 17-03-2017 IPR026877 DXP reductoisomerase C-terminal domain KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 Gene3D G3DSA:1.10.1740.10 325 408 4.2E-29 T 17-03-2017 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 SUPERFAMILY SSF55347 150 286 1.18E-53 T 17-03-2017 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 TIGRFAM TIGR00243 Dxr: 1-deoxy-D-xylulose 5-phosphate reductoisomerase 22 410 2.1E-110 T 17-03-2017 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 Gene3D G3DSA:3.40.50.720 18 172 6.1E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 Hamap MF_00183 1-deoxy-D-xylulose 5-phosphate reductoisomerase [dxr]. 24 407 43.832 T 17-03-2017 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS36865 6881cd9ec7766c3126d828c37b24d51a 420 PIRSF PIRSF006205 21 414 8.3E-140 T 17-03-2017 IPR003821 1-deoxy-D-xylulose 5-phosphate reductoisomerase GO:0008299|GO:0030604|GO:0046872|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00900+1.1.1.267|MetaCyc: PWY-7294|MetaCyc: PWY-7295|MetaCyc: PWY-7560 SHXM_RS29020 967039e3f117a8ea9074216d989a9c6f 108 Gene3D G3DSA:1.10.443.10 26 81 1.9E-5 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS29020 967039e3f117a8ea9074216d989a9c6f 108 SUPERFAMILY SSF56349 26 80 2.94E-6 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 Pfam PF13419 Haloacid dehalogenase-like hydrolase 24 196 1.0E-32 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 141 157 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 159 179 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 21 32 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 110 123 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 92 195 4.9E-9 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 98 190 4.2E-8 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 SUPERFAMILY SSF56784 22 225 2.38E-51 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 TIGRFAM TIGR01454 AHBA_synth_RP: AHBA synthesis associated protein 24 228 3.5E-105 T 17-03-2017 IPR006351 3-amino-5-hydroxybenzoic acid synthesis-related SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 Gene3D G3DSA:3.40.50.1000 101 226 1.1E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS39655 050f02aa9cd451d23a9768ba2dc7869c 232 Gene3D G3DSA:3.40.50.1000 14 35 1.1E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05570 f42208c524d3f4a098d6f17c2855c738 427 SMART SM00387 301 400 2.8E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05570 f42208c524d3f4a098d6f17c2855c738 427 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 304 398 2.9E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05570 f42208c524d3f4a098d6f17c2855c738 427 Gene3D G3DSA:3.30.565.10 269 402 1.1E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05570 f42208c524d3f4a098d6f17c2855c738 427 Pfam PF07730 Histidine kinase 191 258 1.0E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS05570 f42208c524d3f4a098d6f17c2855c738 427 SUPERFAMILY SSF55874 282 398 1.25E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 Gene3D G3DSA:3.40.1190.10 97 319 2.3E-67 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 Gene3D G3DSA:3.90.190.20 322 462 6.5E-45 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 Pfam PF02875 Mur ligase family, glutamate ligase domain 322 391 2.7E-7 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 TIGRFAM TIGR01087 murD: UDP-N-acetylmuramoylalanine--D-glutamate ligase 8 463 1.0E-115 T 17-03-2017 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 Gene3D G3DSA:3.40.50.720 3 96 1.4E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 SUPERFAMILY SSF51984 3 97 4.19E-14 T 17-03-2017 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 Pfam PF08245 Mur ligase middle domain 116 301 1.4E-25 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 Hamap MF_00639 UDP-N-acetylmuramoylalanine--D-glutamate ligase [murD]. 7 465 33.346 T 17-03-2017 IPR005762 UDP-N-acetylmuramoylalanine-D-glutamate ligase GO:0005524|GO:0005737|GO:0008360|GO:0008764|GO:0051301 KEGG: 00471+6.3.2.9|KEGG: 00550+6.3.2.9|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 SUPERFAMILY SSF53623 111 318 1.06E-47 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18575 4c976c02668563d307518fed790b34a4 474 SUPERFAMILY SSF53244 322 465 1.34E-38 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.47.10 1872 2133 2.2E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.47.10 38 296 3.3E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1804 1819 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF14765 Polyketide synthase dehydratase 2780 3067 1.8E-51 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF14765 Polyketide synthase dehydratase 964 1249 8.9E-51 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00823 Phosphopantetheine attachment site 3918 3990 1.5E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00823 Phosphopantetheine attachment site 1777 1849 1.0E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3945 3960 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 284 1.8E-86 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1870 2121 1.9E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.50.720 3444 3539 3.9E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF51735 3625 3822 3.87E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.30.70.250 2531 2598 5.6E-8 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.30.70.250 708 771 3.5E-9 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00829 3310 3617 3.3E-180 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF55048 2531 2599 4.32E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2034 2050 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF51735 3076 3285 1.06E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF00550 Phosphopantetheine attachment site 3921 3986 5.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF00550 Phosphopantetheine attachment site 1779 1845 1.0E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.47.10 2134 2299 6.1E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.47.10 297 463 1.1E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 581 898 1.8E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2408 2711 1.7E-116 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.50.720 1493 1677 3.0E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF53901 1866 2243 2.28E-102 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF00698 Acyl transferase domain 580 868 3.2E-53 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF00698 Acyl transferase domain 2407 2730 4.1E-82 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM01294 1778 1845 5.9E-6 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM01294 3919 3986 3.1E-5 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2129 2246 1.1E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 7.6E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF101173 3 36 2.88E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF55048 708 772 1.31E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.90.180.10 3324 3443 7.1E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF13602 Zinc-binding dehydrogenase 3486 3617 7.1E-20 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:1.10.1200.10 3915 3991 1.1E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:1.10.1200.10 1776 1849 4.2E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.366.10 2404 2527 1.8E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.366.10 572 703 2.6E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.366.10 772 870 2.6E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.366.10 2599 2715 1.8E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Gene3D G3DSA:3.40.50.720 3627 3824 2.9E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF47336 3911 3998 6.41E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF51735 3410 3588 2.63E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00825 Beta-ketoacyl synthase 1872 2299 3.4E-223 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00825 Beta-ketoacyl synthase 38 462 2.2E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF52151 578 709 9.16E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF52151 773 869 9.16E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF52151 2406 2533 1.02E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF52151 2600 2702 1.02E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1494 1675 2.3E-49 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3627 3807 6.3E-52 T 17-03-2017 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 3329 3385 5.4E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF50129 3307 3443 9.75E-28 T 17-03-2017 IPR011032 GroES-like SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF08659 KR domain 3627 3806 3.3E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF08659 KR domain 1494 1673 7.3E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF51735 1260 1463 5.12E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 412 543 5.9E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2249 2368 9.7E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF53901 33 400 9.17E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 Pfam PF08990 Erythronolide synthase docking 4 29 6.3E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00826 2780 2947 2.6E-73 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SMART SM00826 964 1134 1.8E-75 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF47336 1774 1885 7.07E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06450 f50f7a0240bf0432cba604ee212f6249 4075 SUPERFAMILY SSF51735 1491 1730 4.31E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49075 549a0cdec63d204366de812f026373e8 254 Pfam PF08241 Methyltransferase domain 53 140 1.8E-7 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS49075 549a0cdec63d204366de812f026373e8 254 Gene3D G3DSA:3.40.50.150 52 252 2.3E-17 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS49075 549a0cdec63d204366de812f026373e8 254 SUPERFAMILY SSF53335 46 251 2.46E-18 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06490 7c12f63e450d60cb1399bf3a21aa6b29 388 SMART SM00854 52 302 5.4E-70 T 17-03-2017 IPR019079 Capsule synthesis protein, CapA SHXM_RS06490 7c12f63e450d60cb1399bf3a21aa6b29 388 Gene3D G3DSA:3.60.21.10 52 343 4.9E-23 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS06490 7c12f63e450d60cb1399bf3a21aa6b29 388 Pfam PF09587 Bacterial capsule synthesis protein PGA_cap 52 300 3.0E-65 T 17-03-2017 IPR019079 Capsule synthesis protein, CapA SHXM_RS06490 7c12f63e450d60cb1399bf3a21aa6b29 388 SUPERFAMILY SSF56300 52 301 5.37E-33 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS42505 b40f3ed9c691789e504210870722fb02 308 SUPERFAMILY SSF52540 2 221 3.07E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42505 b40f3ed9c691789e504210870722fb02 308 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS42505 b40f3ed9c691789e504210870722fb02 308 Gene3D G3DSA:3.40.50.300 2 224 3.1E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42505 b40f3ed9c691789e504210870722fb02 308 SMART SM00382 29 209 3.2E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS42505 b40f3ed9c691789e504210870722fb02 308 Pfam PF00005 ABC transporter 21 158 6.6E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17220 4cd2a513104a349f57ec857c6efa882c 167 Pfam PF14279 HNH endonuclease 84 134 4.9E-10 T 17-03-2017 IPR029471 HNH endonuclease 5 SHXM_RS17220 4cd2a513104a349f57ec857c6efa882c 167 SMART SM00507 71 120 8.2E-11 T 17-03-2017 IPR003615 HNH nuclease SHXM_RS14500 679388e31fc22aa3a62611cc86aebd7f 260 Pfam PF12706 Beta-lactamase superfamily domain 21 209 3.8E-29 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14500 679388e31fc22aa3a62611cc86aebd7f 260 SUPERFAMILY SSF56281 4 213 1.15E-23 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14500 679388e31fc22aa3a62611cc86aebd7f 260 Gene3D G3DSA:3.60.15.10 2 257 1.7E-49 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 Pfam PF00210 Ferritin-like domain 18 153 2.3E-24 T 17-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 Gene3D G3DSA:1.20.1260.10 3 154 2.8E-47 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 38 54 7.9E-13 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 133 151 7.9E-13 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 62 78 7.9E-13 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 SUPERFAMILY SSF47240 3 153 1.5E-47 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 PIRSF PIRSF005900 1 159 2.3E-45 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS37190 32ad7210d796b59a498d2182732a6e9a 160 ProSitePatterns PS00818 Dps protein family signature 1. 38 54 - T 17-03-2017 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 SHXM_RS17475 b38ddd3e821ebb21b0fc11d921e7e501 259 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 115 135 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS17475 b38ddd3e821ebb21b0fc11d921e7e501 259 Gene3D G3DSA:3.90.226.10 7 251 7.3E-59 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS17475 b38ddd3e821ebb21b0fc11d921e7e501 259 SUPERFAMILY SSF52096 7 251 9.03E-62 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS17475 b38ddd3e821ebb21b0fc11d921e7e501 259 Pfam PF00378 Enoyl-CoA hydratase/isomerase 15 246 8.3E-37 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 SUPERFAMILY SSF47819 655 734 4.36E-20 T 17-03-2017 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 SMART SM00341 662 742 9.5E-16 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Pfam PF00580 UvrD/REP helicase N-terminal domain 186 295 1.9E-25 T 17-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Pfam PF00580 UvrD/REP helicase N-terminal domain 33 109 1.7E-20 T 17-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Gene3D G3DSA:3.40.50.300 517 600 5.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Gene3D G3DSA:3.40.50.300 307 426 5.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Gene3D G3DSA:3.40.50.300 32 301 3.2E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Pfam PF00570 HRDC domain 666 731 4.6E-20 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 SUPERFAMILY SSF52540 29 600 2.66E-118 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Gene3D G3DSA:1.10.150.80 665 728 8.1E-13 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Pfam PF13361 UvrD-like helicase C-terminal domain 473 580 6.1E-23 T 17-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SHXM_RS34300 39925f04e8704d78f37c6d59203df28e 764 Pfam PF13361 UvrD-like helicase C-terminal domain 303 432 7.0E-13 T 17-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 Pfam PF07690 Major Facilitator Superfamily 21 411 7.3E-47 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 Gene3D G3DSA:1.20.1250.20 474 507 2.6E-16 T 17-03-2017 SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 Gene3D G3DSA:1.20.1250.20 268 422 2.6E-16 T 17-03-2017 SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 SUPERFAMILY SSF103473 473 500 4.19E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 SUPERFAMILY SSF103473 9 197 4.19E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 SUPERFAMILY SSF103473 250 421 4.19E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS50720 3f8ba368f3914e6adf9c9237a3230803 522 Gene3D G3DSA:1.20.1250.20 16 202 5.5E-26 T 17-03-2017 SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 SMART SM00567 E-Z type HEAT repeats 54 83 1.7 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 SMART SM00567 E-Z type HEAT repeats 154 183 0.62 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 SMART SM00567 E-Z type HEAT repeats 85 114 300.0 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 SUPERFAMILY SSF48371 139 195 3.45E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 SUPERFAMILY SSF48371 25 102 3.45E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 Gene3D G3DSA:1.25.10.10 56 101 5.3E-14 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 Gene3D G3DSA:1.25.10.10 134 202 5.3E-14 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS14705 6efc45f25592f4ad199893e96dbf4500 226 Pfam PF03130 PBS lyase HEAT-like repeat 158 182 2.2E-5 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 SUPERFAMILY SSF103473 4 193 9.55E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 SUPERFAMILY SSF103473 243 414 9.55E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 SUPERFAMILY SSF103473 461 487 9.55E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 Pfam PF07690 Major Facilitator Superfamily 13 404 8.2E-52 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 Gene3D G3DSA:1.20.1250.20 10 188 9.6E-28 T 17-03-2017 SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 Gene3D G3DSA:1.20.1250.20 258 415 1.3E-15 T 17-03-2017 SHXM_RS00375 f7e2e47f874ac9206e264fda8dea7f3e 497 Gene3D G3DSA:1.20.1250.20 462 486 1.3E-15 T 17-03-2017 SHXM_RS08945 77df27b3f42a5e805f6a284532557a37 310 Hamap MF_00313 Glutaminase [glsA]. 10 310 44.686 T 17-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 SHXM_RS08945 77df27b3f42a5e805f6a284532557a37 310 TIGRFAM TIGR03814 Gln_ase: glutaminase A 14 310 1.2E-118 T 17-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 SHXM_RS08945 77df27b3f42a5e805f6a284532557a37 310 SUPERFAMILY SSF56601 8 310 4.06E-100 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS08945 77df27b3f42a5e805f6a284532557a37 310 Pfam PF04960 Glutaminase 28 310 1.5E-104 T 17-03-2017 IPR015868 Glutaminase GO:0004359|GO:0006541 KEGG: 00220+3.5.1.2|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|Reactome: R-HSA-210500|Reactome: R-HSA-5628897|Reactome: R-HSA-70614 SHXM_RS08945 77df27b3f42a5e805f6a284532557a37 310 Gene3D G3DSA:3.40.710.10 9 310 3.0E-112 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS00530 5d64ba590ca8609c5cdb1f95cf4c438c 453 ProSitePatterns PS00217 Sugar transport proteins signature 2. 143 168 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS00530 5d64ba590ca8609c5cdb1f95cf4c438c 453 Pfam PF07690 Major Facilitator Superfamily 54 299 1.9E-25 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS00530 5d64ba590ca8609c5cdb1f95cf4c438c 453 Gene3D G3DSA:1.20.1250.20 30 239 9.9E-25 T 17-03-2017 SHXM_RS00530 5d64ba590ca8609c5cdb1f95cf4c438c 453 Gene3D G3DSA:1.20.1250.20 253 440 2.7E-22 T 17-03-2017 SHXM_RS00530 5d64ba590ca8609c5cdb1f95cf4c438c 453 ProSitePatterns PS00216 Sugar transport proteins signature 1. 313 329 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS00530 5d64ba590ca8609c5cdb1f95cf4c438c 453 SUPERFAMILY SSF103473 5 445 1.7E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 SMART SM00448 3 118 3.0E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 Gene3D G3DSA:3.40.50.2300 2 125 3.5E-32 T 17-03-2017 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 Pfam PF00072 Response regulator receiver domain 5 118 3.0E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 SUPERFAMILY SSF52172 2 132 1.07E-29 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 199 211 5.0E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 199 5.0E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 183 5.0E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 Gene3D G3DSA:1.10.10.10 126 230 8.0E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 SMART SM00421 166 223 9.4E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 Pfam PF00196 Bacterial regulatory proteins, luxR family 168 223 3.5E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 ProSitePatterns PS00622 LuxR-type HTH domain signature. 183 210 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04830 d99b9e3e74403efa56258687ad812ffd 238 SUPERFAMILY SSF46894 164 230 3.2E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 3 169 5.1E-48 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 SUPERFAMILY SSF52518 1 181 6.39E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 Gene3D G3DSA:3.40.50.970 362 565 2.4E-57 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 SUPERFAMILY SSF52518 364 563 4.29E-55 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 SUPERFAMILY SSF52467 192 357 6.41E-41 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 198 327 1.1E-25 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 Gene3D G3DSA:3.40.50.1220 193 352 4.7E-39 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 388 542 6.2E-31 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 425 444 - T 17-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SHXM_RS14600 bdc262783748f2ce1ecb601f3ce7ef7e 609 Gene3D G3DSA:3.40.50.970 1 180 2.5E-60 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 SUPERFAMILY SSF50129 1 141 1.23E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 SUPERFAMILY SSF50129 312 334 1.23E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 Pfam PF00107 Zinc-binding dehydrogenase 174 302 7.1E-25 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 132 6.3E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 SMART SM00829 11 341 3.3E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 Gene3D G3DSA:3.40.50.720 168 285 4.1E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 SUPERFAMILY SSF51735 137 308 3.84E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03090 9b269251270ecd28d9c03d25a1171d4d 343 Gene3D G3DSA:3.90.180.10 1 167 6.3E-53 T 17-03-2017 IPR011032 GroES-like SHXM_RS00745 de8826b5c1ae90e7bdf48737446f581f 407 SUPERFAMILY SSF89796 7 407 8.11E-126 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS00745 de8826b5c1ae90e7bdf48737446f581f 407 Pfam PF02515 CoA-transferase family III 10 383 8.4E-125 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS00745 de8826b5c1ae90e7bdf48737446f581f 407 Gene3D G3DSA:3.30.1540.10 235 318 3.1E-18 T 17-03-2017 SHXM_RS00745 de8826b5c1ae90e7bdf48737446f581f 407 Gene3D G3DSA:3.40.50.10540 7 225 8.5E-105 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS00745 de8826b5c1ae90e7bdf48737446f581f 407 Gene3D G3DSA:3.40.50.10540 319 407 8.5E-105 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 ProSitePatterns PS00636 Nt-dnaJ domain signature. 52 71 - T 17-03-2017 IPR018253 DnaJ domain, conserved site SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Gene3D G3DSA:2.60.260.20 121 170 2.7E-21 T 17-03-2017 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Gene3D G3DSA:2.60.260.20 239 282 2.7E-21 T 17-03-2017 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Gene3D G3DSA:1.10.287.110 4 99 2.0E-31 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 SUPERFAMILY SSF46565 9 114 3.14E-29 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Hamap MF_01152 Chaperone protein DnaJ [dnaJ]. 7 396 37.203 T 17-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Pfam PF00684 DnaJ central domain 176 236 8.9E-9 T 17-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Pfam PF01556 DnaJ C terminal domain 149 362 6.4E-35 T 17-03-2017 IPR002939 Chaperone DnaJ, C-terminal SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 SUPERFAMILY SSF57938 163 238 6.02E-13 T 17-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 SUPERFAMILY SSF49493 288 373 3.27E-21 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 PRINTS PR00625 DnaJ domain signature 47 67 1.9E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 PRINTS PR00625 DnaJ domain signature 12 30 1.9E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 PRINTS PR00625 DnaJ domain signature 30 45 1.9E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 PRINTS PR00625 DnaJ domain signature 67 86 1.9E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Gene3D G3DSA:2.60.260.20 285 363 2.2E-21 T 17-03-2017 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 SMART SM00271 9 67 1.2E-29 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 TIGRFAM TIGR02349 DnaJ_bact: chaperone protein DnaJ 10 379 1.4E-118 T 17-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Pfam PF00226 DnaJ domain 10 72 9.5E-27 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 Gene3D G3DSA:2.10.230.10 171 238 4.5E-15 T 17-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 SUPERFAMILY SSF49493 143 167 6.67E-20 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS29095 dcb8db01ddb54fdf3abcae73d496d354 396 SUPERFAMILY SSF49493 229 295 6.67E-20 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS14785 00f5f690b7aad2ef0cb9b4fcc3ec6dc3 269 SUPERFAMILY SSF46689 32 98 7.98E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14785 00f5f690b7aad2ef0cb9b4fcc3ec6dc3 269 Gene3D G3DSA:1.10.357.10 33 202 4.7E-33 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS14785 00f5f690b7aad2ef0cb9b4fcc3ec6dc3 269 Pfam PF00440 Bacterial regulatory proteins, tetR family 42 88 3.0E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14785 00f5f690b7aad2ef0cb9b4fcc3ec6dc3 269 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 55 1.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14785 00f5f690b7aad2ef0cb9b4fcc3ec6dc3 269 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 63 86 1.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14785 00f5f690b7aad2ef0cb9b4fcc3ec6dc3 269 SUPERFAMILY SSF48498 111 175 6.6E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 328 343 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 358 369 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 282 293 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 99 110 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 163 178 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 200 222 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 300 327 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 146 162 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00359 B-class P450 signature 349 358 1.6E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 Gene3D G3DSA:1.10.630.10 24 409 4.3E-118 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 SUPERFAMILY SSF48264 25 409 1.26E-85 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 Pfam PF00067 Cytochrome P450 228 375 2.0E-18 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 351 360 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00385 P450 superfamily signature 282 293 1.8E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00385 P450 superfamily signature 349 358 1.8E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00385 P450 superfamily signature 358 369 1.8E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04560 fa6968f36b3d6932c633e98018b589a4 409 PRINTS PR00385 P450 superfamily signature 245 262 1.8E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 2.7E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 2.7E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 222 242 2.7E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 2.7E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 2.7E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 2.7E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 7.3E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 7.3E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 7.3E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 SUPERFAMILY SSF51735 7 259 2.26E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 259 8.1E-54 T 17-03-2017 SHXM_RS01005 66ca2597f5f5e5e6611a3c38a3f35c0a 262 Gene3D G3DSA:3.40.50.720 2 259 2.7E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 ProSitePatterns PS00713 Sodium:dicarboxylate symporter family signature 1. 55 70 - T 17-03-2017 IPR018107 Sodium:dicarboxylate symporter, conserved site SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 PRINTS PR00173 Glutamate-aspartate symporter signature 208 227 6.2E-26 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 PRINTS PR00173 Glutamate-aspartate symporter signature 309 335 6.2E-26 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 PRINTS PR00173 Glutamate-aspartate symporter signature 344 363 6.2E-26 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 PRINTS PR00173 Glutamate-aspartate symporter signature 26 46 6.2E-26 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 PRINTS PR00173 Glutamate-aspartate symporter signature 93 118 6.2E-26 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 Gene3D G3DSA:1.10.3860.10 26 424 3.2E-106 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 SUPERFAMILY SSF118215 28 418 1.96E-103 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS35680 20ba5dc249c9b53b9c13254e39730589 479 Pfam PF00375 Sodium:dicarboxylate symporter family 28 418 1.6E-101 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Gene3D G3DSA:3.30.450.20 205 305 2.9E-6 T 17-03-2017 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Gene3D G3DSA:3.30.565.10 379 537 4.7E-23 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 SMART SM00387 411 539 9.0E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 SUPERFAMILY SSF103190 30 155 8.63E-12 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 SUPERFAMILY SSF55785 215 316 1.36E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Gene3D G3DSA:3.30.450.20 21 154 5.7E-17 T 17-03-2017 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 413 529 1.1E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 SMART SM00091 204 269 6.3E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Pfam PF00989 PAS fold 204 305 1.3E-5 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Pfam PF14689 Sensor_kinase_SpoOB-type, alpha-helical domain 314 365 1.2E-11 T 17-03-2017 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Gene3D G3DSA:1.10.287.130 306 367 2.6E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 SUPERFAMILY SSF55874 381 529 5.11E-21 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 SUPERFAMILY SSF55890 321 363 1.19E-10 T 17-03-2017 IPR016120 Signal transduction histidine kinase, sporulation regulator SpoOB GO:0000155|GO:0000160|GO:0016772 SHXM_RS10805 728ee6487fb3dfe8042ad4cf0c42ab67 546 Pfam PF17203 Single cache domain 3 25 160 1.1E-11 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS38950 50d62a6b30899fcebf5a81d0db38b698 112 Pfam PF00576 HIUase/Transthyretin family 8 111 1.1E-33 T 17-03-2017 IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 SHXM_RS38950 50d62a6b30899fcebf5a81d0db38b698 112 Gene3D G3DSA:2.60.40.180 6 112 6.8E-34 T 17-03-2017 IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 SHXM_RS38950 50d62a6b30899fcebf5a81d0db38b698 112 ProSitePatterns PS00769 Transthyretin signature 2. 95 107 - T 17-03-2017 IPR023419 Transthyretin, conserved site Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 SHXM_RS38950 50d62a6b30899fcebf5a81d0db38b698 112 SUPERFAMILY SSF49472 6 112 3.27E-30 T 17-03-2017 IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 SHXM_RS38950 50d62a6b30899fcebf5a81d0db38b698 112 TIGRFAM TIGR02962 hdxy_isourate: hydroxyisourate hydrolase 6 112 4.6E-30 T 17-03-2017 IPR014306 Hydroxyisourate hydrolase GO:0006144|GO:0033971 KEGG: 00230+3.5.2.17|MetaCyc: PWY-5691|MetaCyc: PWY-7394 SHXM_RS38950 50d62a6b30899fcebf5a81d0db38b698 112 ProSitePatterns PS00768 Transthyretin signature 1. 11 26 - T 17-03-2017 IPR023418 Transthyretin, thyroxine binding site Reactome: R-HSA-2453864|Reactome: R-HSA-2453902|Reactome: R-HSA-3000171|Reactome: R-HSA-975634|Reactome: R-HSA-977225 SHXM_RS31060 4580e6927706ae129f2f3d643059c318 343 Pfam PF00962 Adenosine/AMP deaminase 8 328 2.1E-91 T 17-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 SHXM_RS31060 4580e6927706ae129f2f3d643059c318 343 Gene3D G3DSA:3.20.20.140 6 334 2.9E-85 T 17-03-2017 SHXM_RS31060 4580e6927706ae129f2f3d643059c318 343 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 8 330 1.8E-112 T 17-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 SHXM_RS31060 4580e6927706ae129f2f3d643059c318 343 SUPERFAMILY SSF51556 6 334 4.86E-70 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31060 4580e6927706ae129f2f3d643059c318 343 ProSitePatterns PS00485 Adenosine and AMP deaminase signature. 275 281 - T 17-03-2017 IPR006650 Adenosine/AMP deaminase active site GO:0009168|GO:0019239 Reactome: R-HSA-74217 SHXM_RS30625 276958d9585c11e59beaa3f7f9941460 364 Pfam PF01578 Cytochrome C assembly protein 141 356 5.8E-48 T 17-03-2017 IPR002541 Cytochrome c assembly protein GO:0017004|GO:0020037 SHXM_RS30625 276958d9585c11e59beaa3f7f9941460 364 TIGRFAM TIGR03144 cytochr_II_ccsB: cytochrome c-type biogenesis protein CcsB 118 362 8.7E-78 T 17-03-2017 IPR017562 Cytochrome c-type biogenesis protein CcsA GO:0017004 SHXM_RS40165 50cf60d815b4af583316f72c23b2a2a3 233 ProSitePatterns PS00893 Nudix box signature. 127 148 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS40165 50cf60d815b4af583316f72c23b2a2a3 233 Pfam PF00293 NUDIX domain 99 209 3.2E-14 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS40165 50cf60d815b4af583316f72c23b2a2a3 233 Gene3D G3DSA:3.90.79.10 90 217 7.5E-20 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS40165 50cf60d815b4af583316f72c23b2a2a3 233 SUPERFAMILY SSF55811 91 224 3.52E-21 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 Hamap MF_01416 ATP synthase subunit delta [atpD]. 95 271 15.049 T 17-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 SUPERFAMILY SSF47928 110 198 6.41E-5 T 17-03-2017 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain Reactome: R-HSA-163210 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 PRINTS PR00125 ATP synthase delta subunit signature 229 244 2.7E-7 T 17-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 PRINTS PR00125 ATP synthase delta subunit signature 244 262 2.7E-7 T 17-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 Pfam PF00213 ATP synthase delta (OSCP) subunit 109 268 3.6E-33 T 17-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 TIGRFAM TIGR01145 ATP_synt_delta: ATP synthase F1, delta subunit 111 267 3.1E-22 T 17-03-2017 IPR000711 ATPase, OSCP/delta subunit GO:0015986|GO:0046933 Reactome: R-HSA-163210 SHXM_RS35245 319f6dc0c723df39c163d731e7c20c90 271 Gene3D G3DSA:1.10.520.20 109 198 2.3E-5 T 17-03-2017 IPR026015 F1F0 ATP synthase OSCP/delta subunit, N-terminal domain Reactome: R-HSA-163210 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 64 3.1E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 Gene3D G3DSA:3.40.190.10 91 171 7.8E-14 T 17-03-2017 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 Gene3D G3DSA:3.40.190.10 172 254 2.7E-7 T 17-03-2017 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 Gene3D G3DSA:1.10.10.10 4 86 2.0E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 1.4E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 1.4E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 1.4E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 SUPERFAMILY SSF46785 3 101 7.96E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 Pfam PF03466 LysR substrate binding domain 89 279 6.7E-23 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS15135 7213bdc1b0f541da1d5284ccbc63dd0a 288 SUPERFAMILY SSF53850 89 282 3.98E-22 T 17-03-2017 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 PRINTS PR00315 GTP-binding elongation factor signature 24 37 5.6E-10 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 PRINTS PR00315 GTP-binding elongation factor signature 95 105 5.6E-10 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 PRINTS PR00315 GTP-binding elongation factor signature 111 122 5.6E-10 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 PRINTS PR00315 GTP-binding elongation factor signature 148 157 5.6E-10 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 Gene3D G3DSA:2.40.30.10 241 293 3.4E-4 T 17-03-2017 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 Pfam PF00009 Elongation factor Tu GTP binding domain 23 220 9.4E-34 T 17-03-2017 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 SUPERFAMILY SSF52540 22 236 2.35E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 SUPERFAMILY SSF50447 221 304 8.58E-6 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 22 196 1.3E-11 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 SUPERFAMILY SSF50465 312 412 3.96E-5 T 17-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal SHXM_RS11965 b9e9bfd82c07e843b3c3587821dadd2b 421 Gene3D G3DSA:3.40.50.300 18 219 6.8E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08550 aa18133881e725a4c4c56d6d7987a2e9 227 SUPERFAMILY SSF53335 43 221 3.28E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08550 aa18133881e725a4c4c56d6d7987a2e9 227 Gene3D G3DSA:3.40.50.150 41 197 1.4E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08550 aa18133881e725a4c4c56d6d7987a2e9 227 Pfam PF08241 Methyltransferase domain 52 144 8.0E-17 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS36430 1c54d8b5d2e0c05a8e001465e236d8c9 195 TIGRFAM TIGR00095 TIGR00095: 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD 2 184 5.9E-43 T 17-03-2017 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS36430 1c54d8b5d2e0c05a8e001465e236d8c9 195 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 120 126 - T 17-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SHXM_RS36430 1c54d8b5d2e0c05a8e001465e236d8c9 195 SUPERFAMILY SSF53335 2 182 8.51E-42 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36430 1c54d8b5d2e0c05a8e001465e236d8c9 195 Pfam PF03602 Conserved hypothetical protein 95 2 184 2.8E-50 T 17-03-2017 SHXM_RS36430 1c54d8b5d2e0c05a8e001465e236d8c9 195 Gene3D G3DSA:3.40.50.150 1 187 3.9E-57 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36430 1c54d8b5d2e0c05a8e001465e236d8c9 195 PIRSF PIRSF004553 1 188 4.9E-49 T 17-03-2017 IPR004398 RNA methyltransferase, RsmD GO:0008168|GO:0031167 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS39650 bcbb1615891805b28ab7a11edce83650 366 Gene3D G3DSA:3.40.50.720 3 142 1.7E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39650 bcbb1615891805b28ab7a11edce83650 366 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 4 111 3.1E-21 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS39650 bcbb1615891805b28ab7a11edce83650 366 SUPERFAMILY SSF51735 3 150 5.1E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39650 bcbb1615891805b28ab7a11edce83650 366 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 137 191 3.7E-7 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS39650 bcbb1615891805b28ab7a11edce83650 366 Gene3D G3DSA:3.30.360.10 143 346 2.9E-28 T 17-03-2017 SHXM_RS39650 bcbb1615891805b28ab7a11edce83650 366 SUPERFAMILY SSF55347 137 301 2.45E-21 T 17-03-2017 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 101 462 6.1E-41 T 17-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 SUPERFAMILY SSF55681 411 482 8.76E-90 T 17-03-2017 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 SUPERFAMILY SSF55681 17 244 8.76E-90 T 17-03-2017 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Hamap MF_01569 Proline--tRNA ligase [proS]. 8 572 36.632 T 17-03-2017 IPR023717 Prolyl-tRNA synthetase, class IIa, type 1 GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 SUPERFAMILY SSF52954 468 569 1.96E-25 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Gene3D G3DSA:3.90.960.10 262 375 4.4E-19 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Pfam PF04073 Aminoacyl-tRNA editing domain 263 379 3.6E-26 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 TIGRFAM TIGR00409 proS_fam_II: proline--tRNA ligase 9 565 1.3E-172 T 17-03-2017 IPR004500 Prolyl-tRNA synthetase, class IIa, bacterial-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 PRINTS PR01046 Prolyl-tRNA synthetase signature 111 122 1.2E-15 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 PRINTS PR01046 Prolyl-tRNA synthetase signature 75 93 1.2E-15 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 PRINTS PR01046 Prolyl-tRNA synthetase signature 151 162 1.2E-15 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 PRINTS PR01046 Prolyl-tRNA synthetase signature 141 149 1.2E-15 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 SUPERFAMILY SSF55826 257 399 3.14E-20 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Pfam PF03129 Anticodon binding domain 480 568 5.3E-16 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Gene3D G3DSA:3.40.50.800 476 570 7.9E-24 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Gene3D G3DSA:3.30.930.10 17 241 1.1E-94 T 17-03-2017 SHXM_RS36890 657925bae162c74b256a11dbb83de077 573 Gene3D G3DSA:3.30.930.10 393 475 1.1E-94 T 17-03-2017 SHXM_RS42240 fa97dc9ec86c49e5575c6633848bde52 354 SUPERFAMILY SSF51395 5 353 7.09E-108 T 17-03-2017 SHXM_RS42240 fa97dc9ec86c49e5575c6633848bde52 354 Gene3D G3DSA:3.20.20.70 5 351 5.4E-117 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS42240 fa97dc9ec86c49e5575c6633848bde52 354 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 5 329 5.9E-71 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 SMART SM00065 34 179 1.3E-9 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 SMART SM00065 259 393 0.038 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 SMART SM00387 543 636 3.9E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 547 635 9.5E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 Pfam PF13185 GAF domain 34 169 1.1E-12 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 SUPERFAMILY SSF55874 510 633 2.36E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 SUPERFAMILY SSF55781 36 182 2.84E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 Gene3D G3DSA:3.30.565.10 510 636 1.2E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 Gene3D G3DSA:3.30.450.40 260 387 1.4E-7 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 Gene3D G3DSA:3.30.450.40 14 182 1.3E-24 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 SUPERFAMILY SSF55781 262 395 3.49E-11 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS26650 d1559343e3ff1dfbae0229ca0be10113 638 Pfam PF07730 Histidine kinase 400 437 4.9E-10 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 Gene3D G3DSA:2.30.38.10 345 423 1.6E-23 T 17-03-2017 SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 Gene3D G3DSA:3.30.300.30 424 526 7.4E-30 T 17-03-2017 SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 Gene3D G3DSA:3.40.50.980 188 331 1.4E-24 T 17-03-2017 SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 ProSitePatterns PS00455 Putative AMP-binding domain signature. 182 193 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 Pfam PF13193 AMP-binding enzyme C-terminal domain 438 516 3.6E-20 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 Pfam PF00501 AMP-binding enzyme 38 429 9.6E-84 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 Gene3D G3DSA:3.40.50.980 38 187 1.2E-34 T 17-03-2017 SHXM_RS00525 54cef0ff607ceed1134011137a54a9bf 546 SUPERFAMILY SSF56801 22 528 5.89E-142 T 17-03-2017 SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 SUPERFAMILY SSF51735 51 281 2.63E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 192 211 8.7E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 230 8.7E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 247 267 8.7E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 53 70 8.7E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 182 8.7E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 63 281 1.5E-34 T 17-03-2017 SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 Gene3D G3DSA:3.40.50.720 51 281 1.7E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12030 95cd3ec60fdbe3b9593587d666b47c74 285 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 179 207 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 SUPERFAMILY SSF48179 198 292 8.67E-30 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 PIRSF PIRSF500134 4 434 7.6E-147 T 17-03-2017 IPR028357 UDP-glucose 6-dehydrogenase, bacterial type GO:0000271|GO:0003979 KEGG: 00040+1.1.1.22|KEGG: 00053+1.1.1.22|KEGG: 00500+1.1.1.22|KEGG: 00520+1.1.1.22|MetaCyc: PWY-7346 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 5 412 3.5E-129 T 17-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 Gene3D G3DSA:3.40.50.720 5 200 8.8E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 PIRSF PIRSF000124 4 431 1.5E-124 T 17-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 SUPERFAMILY SSF51735 4 187 1.63E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 SUPERFAMILY SSF52413 307 425 6.15E-32 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 SMART SM00984 315 416 1.6E-41 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 Gene3D G3DSA:1.20.5.100 201 225 6.9E-12 T 17-03-2017 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 315 416 4.8E-28 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 Gene3D G3DSA:3.40.50.720 227 433 6.8E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 198 288 1.7E-33 T 17-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS05760 726ece4c2b76eab1559ffd1bdfec19f5 437 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 5 178 7.0E-57 T 17-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 Gene3D G3DSA:3.40.50.2020 290 456 8.4E-44 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 SUPERFAMILY SSF56235 23 286 1.03E-63 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 PIRSF PIRSF000485 19 482 3.0E-159 T 17-03-2017 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 SUPERFAMILY SSF53271 268 481 1.08E-66 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 Hamap MF_01931 Amidophosphoribosyltransferase [purF]. 22 475 46.449 T 17-03-2017 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 Pfam PF13522 Glutamine amidotransferase domain 84 227 1.1E-14 T 17-03-2017 SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 Pfam PF00156 Phosphoribosyl transferase domain 298 403 1.8E-7 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 Gene3D G3DSA:3.60.20.10 23 274 7.0E-66 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS29410 8c5743acbbdb3cdd67d337add523bf66 519 TIGRFAM TIGR01134 purF: amidophosphoribosyltransferase 23 474 1.0E-154 T 17-03-2017 IPR005854 Amidophosphoribosyltransferase GO:0004044|GO:0009113 KEGG: 00230+2.4.2.14|KEGG: 00250+2.4.2.14|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|MetaCyc: PWY-7282|Reactome: R-HSA-73817 SHXM_RS24085 c9d561a738f7478c8b6a6915da7fe4fe 252 SUPERFAMILY SSF55729 35 212 5.6E-42 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS24085 c9d561a738f7478c8b6a6915da7fe4fe 252 Pfam PF13302 Acetyltransferase (GNAT) domain 44 188 2.7E-29 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS24085 c9d561a738f7478c8b6a6915da7fe4fe 252 Gene3D G3DSA:3.40.630.30 35 212 7.9E-51 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33465 fb1188fdb0004f3896fd9cfae44a2dd7 488 Gene3D G3DSA:3.40.50.300 188 413 5.4E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33465 fb1188fdb0004f3896fd9cfae44a2dd7 488 Gene3D G3DSA:3.30.450.90 86 183 3.4E-39 T 17-03-2017 SHXM_RS33465 fb1188fdb0004f3896fd9cfae44a2dd7 488 SUPERFAMILY SSF52540 70 402 2.0E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33465 fb1188fdb0004f3896fd9cfae44a2dd7 488 Pfam PF00437 Type II/IV secretion system protein 89 365 2.6E-89 T 17-03-2017 IPR001482 Type II secretion system protein E GO:0005524|GO:0006810 SHXM_RS48850 dc1e30179f605004f06e2d38c34d5473 395 Gene3D G3DSA:3.40.50.300 103 328 1.3E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48850 dc1e30179f605004f06e2d38c34d5473 395 SMART SM00382 130 319 7.2E-21 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS48850 dc1e30179f605004f06e2d38c34d5473 395 SUPERFAMILY SSF52540 97 330 1.28E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48850 dc1e30179f605004f06e2d38c34d5473 395 Pfam PF00005 ABC transporter 121 273 2.4E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12405 4074d8e73118beac67df601744464f44 297 Gene3D G3DSA:3.40.50.300 118 290 4.7E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12405 4074d8e73118beac67df601744464f44 297 Pfam PF13671 AAA domain 118 246 2.1E-8 T 17-03-2017 SHXM_RS12405 4074d8e73118beac67df601744464f44 297 SUPERFAMILY SSF52540 117 289 3.16E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37425 7d5be52b3454f8c81ba1142d1c80636c 233 Hamap MF_00052_B Ribonuclease HII [rnhB]. 22 202 34.855 T 17-03-2017 IPR022898 Ribonuclease HII GO:0004523 SHXM_RS37425 7d5be52b3454f8c81ba1142d1c80636c 233 Gene3D G3DSA:3.30.420.10 22 162 1.1E-38 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS37425 7d5be52b3454f8c81ba1142d1c80636c 233 Pfam PF01351 Ribonuclease HII 24 200 2.1E-34 T 17-03-2017 IPR024567 Ribonuclease HII/HIII domain SHXM_RS37425 7d5be52b3454f8c81ba1142d1c80636c 233 SUPERFAMILY SSF53098 18 208 1.05E-55 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS49175 06f8a87bfaafa7b3a7e95ab8cec2768f 61 SUPERFAMILY SSF51735 14 58 4.6E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49175 06f8a87bfaafa7b3a7e95ab8cec2768f 61 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 14 57 7.0E-7 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS49175 06f8a87bfaafa7b3a7e95ab8cec2768f 61 Gene3D G3DSA:3.40.50.720 14 59 3.0E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 Gene3D G3DSA:3.50.50.60 199 368 1.8E-7 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 15 337 1.3E-52 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 14 33 7.3E-10 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 149 167 7.3E-10 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 318 340 7.3E-10 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 189 207 7.3E-10 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 Gene3D G3DSA:3.50.50.60 8 198 3.6E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 189 214 2.9E-5 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 13 35 2.9E-5 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 152 161 2.9E-5 T 17-03-2017 SHXM_RS04575 b877720f39495684a4236dfdb0aa85e1 534 SUPERFAMILY SSF51905 13 373 1.08E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33905 1593b0c8f36e0969a1db7b51568d4e30 341 Gene3D G3DSA:1.10.3720.10 132 338 2.7E-27 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33905 1593b0c8f36e0969a1db7b51568d4e30 341 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 65 105 6.6E-10 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS33905 1593b0c8f36e0969a1db7b51568d4e30 341 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 157 341 7.6E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33905 1593b0c8f36e0969a1db7b51568d4e30 341 SUPERFAMILY SSF161098 136 326 1.3E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Gene3D G3DSA:3.40.50.300 359 461 1.1E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Gene3D G3DSA:3.40.50.300 631 722 1.1E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Pfam PF00580 UvrD/REP helicase N-terminal domain 76 344 2.9E-78 T 17-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Pfam PF13361 UvrD-like helicase C-terminal domain 350 693 3.1E-68 T 17-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Gene3D G3DSA:3.40.50.300 71 176 7.0E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Gene3D G3DSA:3.40.50.300 255 358 7.0E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 SUPERFAMILY SSF52540 71 720 1.01E-177 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 TIGRFAM TIGR01073 pcrA: ATP-dependent DNA helicase PcrA 72 822 0.0 T 17-03-2017 IPR005751 ATP-dependent DNA helicase PcrA GO:0004003|GO:0005737|GO:0006268 SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Gene3D G3DSA:1.10.486.10 462 616 9.0E-48 T 17-03-2017 SHXM_RS25345 6f224bb8f435795924a94c6721f20491 824 Gene3D G3DSA:1.10.10.160 180 254 6.0E-25 T 17-03-2017 IPR013986 DExx box DNA helicase domain SHXM_RS48865 4a20e3ed22659afff2728426a3c8afa6 185 Pfam PF00293 NUDIX domain 43 157 1.9E-9 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS48865 4a20e3ed22659afff2728426a3c8afa6 185 SUPERFAMILY SSF55811 33 170 3.93E-15 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS48865 4a20e3ed22659afff2728426a3c8afa6 185 Gene3D G3DSA:3.90.79.10 34 156 1.7E-16 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS02140 9359f214c2dd33fb6f3004a7a883a059 392 Gene3D G3DSA:3.40.47.10 18 258 9.0E-25 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02140 9359f214c2dd33fb6f3004a7a883a059 392 SUPERFAMILY SSF53901 231 355 2.31E-12 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02140 9359f214c2dd33fb6f3004a7a883a059 392 Gene3D G3DSA:3.40.47.10 274 350 4.8E-7 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02140 9359f214c2dd33fb6f3004a7a883a059 392 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 20 214 1.1E-17 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS02140 9359f214c2dd33fb6f3004a7a883a059 392 SUPERFAMILY SSF53901 20 250 7.92E-34 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02140 9359f214c2dd33fb6f3004a7a883a059 392 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 273 348 2.3E-5 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS18505 e4ccef3c77bc213582372a6b50d8942d 154 Gene3D G3DSA:3.40.630.30 6 152 4.0E-38 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS18505 e4ccef3c77bc213582372a6b50d8942d 154 SUPERFAMILY SSF55729 7 154 4.8E-36 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS18505 e4ccef3c77bc213582372a6b50d8942d 154 Pfam PF13673 Acetyltransferase (GNAT) domain 34 152 1.2E-16 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 Gene3D G3DSA:3.40.190.10 217 273 1.4E-5 T 17-03-2017 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 Pfam PF03466 LysR substrate binding domain 106 302 2.7E-25 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 Gene3D G3DSA:3.40.190.10 106 216 1.4E-21 T 17-03-2017 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 Gene3D G3DSA:1.10.10.10 22 103 2.4E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 SUPERFAMILY SSF53850 108 302 5.7E-26 T 17-03-2017 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 47 57 3.9E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 57 68 3.9E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 36 47 3.9E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 SUPERFAMILY SSF46785 21 130 8.16E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40400 904234334aea5e8b1f9bcc9f4770d32d 304 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 23 79 9.9E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 Gene3D G3DSA:3.30.450.40 86 250 7.1E-52 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 Gene3D G3DSA:1.10.10.10 10 74 3.8E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 SUPERFAMILY SSF55781 78 251 3.34E-46 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 Pfam PF01614 Bacterial transcriptional regulator 133 243 2.8E-28 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 SMART SM00346 11 101 3.0E-19 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 SUPERFAMILY SSF46785 11 83 2.06E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17605 748ad38770c5f6835e356c70b5d3b429 256 Pfam PF09339 IclR helix-turn-helix domain 13 63 1.6E-13 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 SUPERFAMILY SSF51604 100 369 2.88E-57 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 Pfam PF13378 Enolase C-terminal domain-like 136 362 6.4E-53 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 SMART SM00922 130 237 1.9E-20 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 34 112 1.5E-5 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 SUPERFAMILY SSF54826 1 112 4.77E-19 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 Gene3D G3DSA:3.30.390.10 1 115 5.3E-25 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS46330 7d6215a6c533e5ab020d4cf206bb3ac0 370 Gene3D G3DSA:3.20.20.120 116 368 8.3E-63 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 Gene3D G3DSA:1.25.40.10 469 652 1.6E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 Gene3D G3DSA:1.10.10.10 708 775 2.3E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 SUPERFAMILY SSF52540 16 278 1.28E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 Pfam PF13401 AAA domain 42 135 1.4E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 SUPERFAMILY SSF48452 501 656 8.13E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 718 732 1.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 748 760 1.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 732 748 1.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 SUPERFAMILY SSF46894 710 775 2.35E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 SMART SM00421 715 772 6.0E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 Gene3D G3DSA:3.40.50.300 25 150 3.4E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 Pfam PF00196 Bacterial regulatory proteins, luxR family 717 771 2.1E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 PRINTS PR00364 Disease resistance protein signature 221 235 3.3E-6 T 17-03-2017 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 PRINTS PR00364 Disease resistance protein signature 112 126 3.3E-6 T 17-03-2017 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 PRINTS PR00364 Disease resistance protein signature 43 58 3.3E-6 T 17-03-2017 SHXM_RS44870 015b7ca3458f1d887a8e92e43f2fae95 791 Pfam PF13424 Tetratricopeptide repeat 502 568 3.8E-7 T 17-03-2017 SHXM_RS47795 48b00a2c9f435faead48280036ecb171 279 SMART SM00530 9 86 4.9E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS47795 48b00a2c9f435faead48280036ecb171 279 Gene3D G3DSA:1.10.260.40 4 85 5.7E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47795 48b00a2c9f435faead48280036ecb171 279 Pfam PF13560 Helix-turn-helix domain 5 89 3.1E-15 T 17-03-2017 SHXM_RS47795 48b00a2c9f435faead48280036ecb171 279 SUPERFAMILY SSF47413 32 84 2.69E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 157 312 6.6E-61 T 17-03-2017 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 SUPERFAMILY SSF55347 152 313 7.14E-63 T 17-03-2017 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 PIRSF PIRSF000149 1 332 8.4E-124 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 Gene3D G3DSA:3.30.360.10 161 314 2.0E-66 T 17-03-2017 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 Gene3D G3DSA:3.40.50.720 1 160 1.1E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 3 324 1.5E-124 T 17-03-2017 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 SMART SM00846 2 152 8.0E-84 T 17-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 SUPERFAMILY SSF51735 3 166 2.26E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3 152 7.9E-54 T 17-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 229 246 1.2E-33 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 146 164 1.2E-33 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 269 284 1.2E-33 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 173 189 1.2E-33 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 109 122 1.2E-33 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS02625 26c4f562a7a2b33d785249b0b1f3d43e 332 ProSitePatterns PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 150 157 - T 17-03-2017 IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS42305 c13270ddb80ee6fef9df57ebfc9ad9b3 684 Pfam PF11308 Glycosyl hydrolases related to GH101 family, GH129 317 636 1.7E-92 T 17-03-2017 IPR021459 Glycosyl hydrolases related to GH101 family, GHL1-GHL3 SHXM_RS32410 53edce1800aab4ad1fe0cae3a926fafa 123 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 2 51 3.3E-19 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS32410 53edce1800aab4ad1fe0cae3a926fafa 123 SMART SM00834 2 41 2.9E-13 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS32410 53edce1800aab4ad1fe0cae3a926fafa 123 Pfam PF09723 Zinc ribbon domain 2 40 1.1E-12 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS42555 fc24da2f70809b59df391dd69115b1a2 289 TIGRFAM TIGR02315 ABC_phnC: phosphonate ABC transporter, ATP-binding protein 1 246 1.6E-80 T 17-03-2017 IPR012693 ABC transporter, phosphonate import, PhnC GO:0005524|GO:0015416|GO:0015716|GO:0016020 SHXM_RS42555 fc24da2f70809b59df391dd69115b1a2 289 SMART SM00382 30 226 1.2E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS42555 fc24da2f70809b59df391dd69115b1a2 289 Pfam PF00005 ABC transporter 22 177 2.6E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS42555 fc24da2f70809b59df391dd69115b1a2 289 SUPERFAMILY SSF52540 1 230 3.67E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42555 fc24da2f70809b59df391dd69115b1a2 289 ProSitePatterns PS00211 ABC transporters family signature. 149 163 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS42555 fc24da2f70809b59df391dd69115b1a2 289 Gene3D G3DSA:3.40.50.300 1 236 4.6E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 SUPERFAMILY SSF51735 150 312 1.76E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 SUPERFAMILY SSF50129 8 172 1.98E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 Gene3D G3DSA:3.40.50.720 182 291 1.1E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 63 77 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 SMART SM00829 15 342 4.1E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 Gene3D G3DSA:3.90.180.10 3 181 1.5E-66 T 17-03-2017 IPR011032 GroES-like SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 Pfam PF00107 Zinc-binding dehydrogenase 186 308 8.4E-19 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS23480 5bf9d383c510822844c355251c98b47d 349 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 30 143 2.6E-29 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 Gene3D G3DSA:3.40.50.970 12 180 6.6E-41 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 392 528 2.2E-29 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 SUPERFAMILY SSF52518 357 536 6.25E-48 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 Gene3D G3DSA:3.40.50.970 354 540 2.6E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 SUPERFAMILY SSF52467 190 346 4.7E-52 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 198 329 2.2E-17 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 12 177 6.2E-38 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 SUPERFAMILY SSF52518 12 183 1.35E-38 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS03265 f369352be1cc825a0879772c2d636366 543 Gene3D G3DSA:3.40.50.1220 189 343 5.2E-41 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 Gene3D G3DSA:1.10.630.10 1 98 2.1E-27 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 Pfam PF00067 Cytochrome P450 1 74 4.8E-24 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 PRINTS PR00465 E-class P450 group IV signature 7 25 1.4E-11 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 PRINTS PR00465 E-class P450 group IV signature 33 49 1.4E-11 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 PRINTS PR00465 E-class P450 group IV signature 49 67 1.4E-11 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 SUPERFAMILY SSF48264 1 97 2.36E-26 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01770 7cf6f8d059f1d85c4ac013b30ab05d1f 104 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 42 51 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS48385 d298c796e324119c653dc68dee7934d0 793 SUPERFAMILY SSF49313 711 786 1.73E-7 T 17-03-2017 IPR015919 Cadherin-like GO:0005509|GO:0016020 SHXM_RS48385 d298c796e324119c653dc68dee7934d0 793 Gene3D G3DSA:2.60.40.10 717 781 4.4E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS48385 d298c796e324119c653dc68dee7934d0 793 Pfam PF05345 Putative Ig domain 740 779 2.3E-8 T 17-03-2017 IPR008009 Putative Ig SHXM_RS42645 c1047d4b2609f60c72b7c3f943b7d544 265 Gene3D G3DSA:1.10.357.10 26 256 8.1E-49 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS42645 c1047d4b2609f60c72b7c3f943b7d544 265 SUPERFAMILY SSF48498 99 253 4.78E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS42645 c1047d4b2609f60c72b7c3f943b7d544 265 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 79 2.9E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42645 c1047d4b2609f60c72b7c3f943b7d544 265 SUPERFAMILY SSF46689 29 87 5.82E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42645 c1047d4b2609f60c72b7c3f943b7d544 265 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 97 250 3.6E-8 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS29820 c06ce1f448b01f344b39008d85f7332e 241 Gene3D G3DSA:1.10.357.10 24 239 8.2E-62 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS29820 c06ce1f448b01f344b39008d85f7332e 241 SUPERFAMILY SSF46689 24 106 1.65E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS29820 c06ce1f448b01f344b39008d85f7332e 241 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 56 79 8.0E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS29820 c06ce1f448b01f344b39008d85f7332e 241 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 49 8.0E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS29820 c06ce1f448b01f344b39008d85f7332e 241 SUPERFAMILY SSF48498 166 237 6.95E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS29820 c06ce1f448b01f344b39008d85f7332e 241 Pfam PF00440 Bacterial regulatory proteins, tetR family 37 80 4.6E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS28330 50266d7c53116447a46d8c608f57c100 316 Gene3D G3DSA:1.20.1260.10 25 279 1.0E-106 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS28330 50266d7c53116447a46d8c608f57c100 316 SUPERFAMILY SSF47240 35 278 1.14E-85 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS28330 50266d7c53116447a46d8c608f57c100 316 Pfam PF05138 Phenylacetic acid catabolic protein 25 299 5.0E-105 T 17-03-2017 IPR007814 1,2-phenylacetyl-CoA epoxidase, subunit A/C GO:0010124 SHXM_RS28330 50266d7c53116447a46d8c608f57c100 316 TIGRFAM TIGR02156 PA_CoA_Oxy1: phenylacetate-CoA oxygenase, PaaG subunit 15 303 2.7E-157 T 17-03-2017 IPR011881 1,2-phenylacetyl-CoA epoxidase, subunit A GO:0010124|GO:0097266 KEGG: 00360+1.14.13.14+1.14.13.149|KEGG: 00940+1.14.13.14|MetaCyc: PWY-5176 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 Gene3D G3DSA:2.40.10.170 10 90 2.7E-29 T 17-03-2017 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 Gene3D G3DSA:3.40.50.300 92 362 6.2E-102 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 Pfam PF02874 ATP synthase alpha/beta family, beta-barrel domain 15 89 5.1E-22 T 17-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 147 360 9.7E-63 T 17-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 SUPERFAMILY SSF47917 363 478 1.73E-44 T 17-03-2017 IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal GO:0015991|GO:0016820|GO:0033178 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 SUPERFAMILY SSF50615 12 90 6.8E-25 T 17-03-2017 IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain GO:0015992|GO:0046034 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 SMART SM00382 159 337 0.0011 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 SUPERFAMILY SSF52540 93 365 3.08E-85 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 Hamap MF_01347 ATP synthase subunit beta [atpB]. 10 478 53.72 T 17-03-2017 IPR005722 ATPase, F1 complex, beta subunit GO:0015986|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-2151201 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 ProSitePatterns PS00152 ATP synthase alpha and beta subunits signature. 351 360 - T 17-03-2017 IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 Gene3D G3DSA:1.10.1140.10 363 478 9.9E-44 T 17-03-2017 IPR024034 ATPase, F1 complex beta subunit/V1 complex, C-terminal KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS35260 c8fad5bc53f5a7d8e0b8dc4dc7ecc2c8 481 TIGRFAM TIGR01039 atpD: ATP synthase F1, beta subunit 12 478 3.0E-232 T 17-03-2017 IPR005722 ATPase, F1 complex, beta subunit GO:0015986|GO:0046933 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210|Reactome: R-HSA-2151201 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 Gene3D G3DSA:3.40.50.2300 54 171 4.3E-25 T 17-03-2017 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 SUPERFAMILY SSF47413 1 60 1.66E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 Pfam PF00356 Bacterial regulatory proteins, lacI family 3 48 2.5E-18 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 Gene3D G3DSA:1.10.260.40 2 53 4.4E-24 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 Gene3D G3DSA:3.40.50.2300 172 312 4.6E-23 T 17-03-2017 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 Pfam PF13377 Periplasmic binding protein-like domain 168 331 4.7E-29 T 17-03-2017 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 ProSitePatterns PS00356 LacI-type HTH domain signature. 4 22 - T 17-03-2017 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 SMART SM00354 1 71 2.6E-26 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS36855 b3cc1758807ec4c3108205644cc0ecaa 338 SUPERFAMILY SSF53822 58 319 3.21E-34 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS40390 9d8e798de8aaa1beeecde90df61fdfce 475 Pfam PF00942 Cellulose binding domain 41 123 1.2E-20 T 17-03-2017 IPR001956 Bacterial type 3a cellulose-binding domain GO:0005975|GO:0030248 SHXM_RS40390 9d8e798de8aaa1beeecde90df61fdfce 475 SUPERFAMILY SSF49384 36 188 1.78E-43 T 17-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 SHXM_RS40390 9d8e798de8aaa1beeecde90df61fdfce 475 SMART SM01067 41 124 1.9E-27 T 17-03-2017 IPR001956 Bacterial type 3a cellulose-binding domain GO:0005975|GO:0030248 SHXM_RS40390 9d8e798de8aaa1beeecde90df61fdfce 475 Gene3D G3DSA:2.60.40.710 39 188 6.0E-45 T 17-03-2017 IPR001956 Bacterial type 3a cellulose-binding domain GO:0005975|GO:0030248 SHXM_RS40390 9d8e798de8aaa1beeecde90df61fdfce 475 Gene3D G3DSA:2.60.120.200 211 441 7.0E-20 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS40390 9d8e798de8aaa1beeecde90df61fdfce 475 SUPERFAMILY SSF49899 210 441 1.04E-18 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 SUPERFAMILY SSF46689 14 75 1.53E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 Pfam PF16859 Bacterial transcriptional repressor C-terminal 86 194 8.9E-25 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 SUPERFAMILY SSF48498 86 200 4.17E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 ProSitePatterns PS01081 TetR-type HTH domain signature. 37 68 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 Gene3D G3DSA:1.10.357.10 64 200 1.1E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 Gene3D G3DSA:1.10.10.60 14 62 2.3E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19380 5c9cbb40a183ad9d0e469e394f7b2b93 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 70 9.5E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05560 36c580a4d318b1b3aa1990f90afb2110 255 Gene3D G3DSA:3.40.50.300 18 234 1.2E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS05560 36c580a4d318b1b3aa1990f90afb2110 255 ProSitePatterns PS00211 ABC transporters family signature. 153 167 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS05560 36c580a4d318b1b3aa1990f90afb2110 255 Pfam PF00005 ABC transporter 34 180 8.7E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS05560 36c580a4d318b1b3aa1990f90afb2110 255 SUPERFAMILY SSF52540 17 233 1.25E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS05560 36c580a4d318b1b3aa1990f90afb2110 255 SMART SM00382 43 229 9.8E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 Gene3D G3DSA:2.40.50.140 45 140 1.4E-16 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 Pfam PF01336 OB-fold nucleic acid binding domain 58 134 5.3E-9 T 17-03-2017 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 Gene3D G3DSA:3.40.50.300 259 468 1.2E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 Pfam PF00271 Helicase conserved C-terminal domain 554 625 3.1E-19 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 Gene3D G3DSA:3.40.50.300 469 674 2.9E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 SUPERFAMILY SSF50249 12 176 4.86E-26 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 SUPERFAMILY SSF52540 191 465 8.82E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 Pfam PF00270 DEAD/DEAH box helicase 296 448 5.3E-16 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 SUPERFAMILY SSF52540 542 638 2.55E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 SUPERFAMILY SSF52540 404 509 2.55E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 SMART SM00490 541 626 1.1E-22 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS36425 46725efd8300d78bbaa19ba386da8884 738 SMART SM00487 270 484 1.8E-31 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Gene3D G3DSA:3.30.1370.10 579 652 1.3E-23 T 17-03-2017 IPR004088 K Homology domain, type 1 GO:0003723 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SUPERFAMILY SSF54211 322 492 3.9E-42 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SUPERFAMILY SSF55666 474 573 1.8E-24 T 17-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SUPERFAMILY SSF54211 6 151 5.57E-46 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Gene3D G3DSA:1.10.10.400 264 335 3.4E-23 T 17-03-2017 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Pfam PF00575 S1 RNA binding domain 648 718 5.4E-13 T 17-03-2017 IPR003029 S1 domain GO:0003676 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Gene3D G3DSA:3.30.230.70 336 570 9.3E-82 T 17-03-2017 IPR027408 PNPase/RNase PH domain Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Gene3D G3DSA:3.30.230.70 8 249 1.4E-83 T 17-03-2017 IPR027408 PNPase/RNase PH domain Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 PIRSF PIRSF005499 7 751 9.6E-283 T 17-03-2017 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Pfam PF01138 3' exoribonuclease family, domain 1 348 480 1.0E-15 T 17-03-2017 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Pfam PF01138 3' exoribonuclease family, domain 1 20 151 3.3E-17 T 17-03-2017 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 TIGRFAM TIGR02696 pppGpp_PNP: guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase 5 722 0.0 T 17-03-2017 IPR014069 Guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase GO:0004654|GO:0005737|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SMART SM00316 649 723 2.7E-18 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 TIGRFAM TIGR03591 polynuc_phos: polyribonucleotide nucleotidyltransferase 17 720 2.3E-261 T 17-03-2017 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Pfam PF03726 Polyribonucleotide nucleotidyltransferase, RNA binding domain 267 343 5.2E-16 T 17-03-2017 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SUPERFAMILY SSF55666 152 260 1.8E-28 T 17-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Pfam PF00013 KH domain 583 639 4.9E-11 T 17-03-2017 IPR004088 K Homology domain, type 1 GO:0003723 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SUPERFAMILY SSF54791 576 688 2.18E-19 T 17-03-2017 IPR004088 K Homology domain, type 1 GO:0003723 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Hamap MF_01595 Polyribonucleotide nucleotidyltransferase [pnp]. 9 725 26.903 T 17-03-2017 IPR012162 Polyribonucleotide nucleotidyltransferase GO:0003723|GO:0004654|GO:0006402 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SMART SM00322 579 643 7.6E-12 T 17-03-2017 IPR004087 K Homology domain GO:0003676 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 SUPERFAMILY SSF46915 264 344 1.18E-16 T 17-03-2017 IPR015848 Polyribonucleotide nucleotidyltransferase, RNA-binding domain GO:0000175|GO:0003723|GO:0006396 KEGG: 00230+2.7.7.8|KEGG: 00240+2.7.7.8 SHXM_RS37070 ec094e66511e507ec5f38ab61ef8737f 751 Gene3D G3DSA:2.40.50.140 653 720 7.0E-18 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 Gene3D G3DSA:1.20.1250.20 208 381 2.1E-13 T 17-03-2017 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 Gene3D G3DSA:1.20.1250.20 15 195 9.8E-24 T 17-03-2017 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 Pfam PF07690 Major Facilitator Superfamily 242 377 6.6E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 Pfam PF07690 Major Facilitator Superfamily 21 235 2.0E-27 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 PRINTS PR01035 Tetracycline resistance protein signature 168 188 2.4E-13 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 PRINTS PR01035 Tetracycline resistance protein signature 284 305 2.4E-13 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 PRINTS PR01035 Tetracycline resistance protein signature 26 42 2.4E-13 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 PRINTS PR01035 Tetracycline resistance protein signature 140 162 2.4E-13 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS46205 0d06f9358e234eb8a49afb43b6936bc9 423 SUPERFAMILY SSF103473 4 380 9.16E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23920 d0ca85221e2dec25de9aade39c43382a 137 Gene3D G3DSA:3.30.70.900 1 94 1.4E-14 T 17-03-2017 SHXM_RS23920 d0ca85221e2dec25de9aade39c43382a 137 Pfam PF07876 Stress responsive A/B Barrel Domain 2 92 1.1E-9 T 17-03-2017 IPR013097 Stress responsive alpha-beta barrel SHXM_RS23920 d0ca85221e2dec25de9aade39c43382a 137 SMART SM00886 2 93 2.2E-8 T 17-03-2017 IPR013097 Stress responsive alpha-beta barrel SHXM_RS23920 d0ca85221e2dec25de9aade39c43382a 137 SUPERFAMILY SSF54909 1 96 4.83E-16 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS13725 6c619ff6213194f60b50332eba5969a4 390 Pfam PF03417 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase 137 297 6.2E-16 T 17-03-2017 IPR005079 Peptidase C45 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 Pfam PF01968 Hydantoinase/oxoprolinase 195 502 8.3E-78 T 17-03-2017 IPR002821 Hydantoinase/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 Gene3D G3DSA:3.30.420.40 2 62 1.3E-5 T 17-03-2017 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 SUPERFAMILY SSF53067 350 363 5.94E-10 T 17-03-2017 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 SUPERFAMILY SSF53067 8 88 5.94E-10 T 17-03-2017 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 SUPERFAMILY SSF53067 396 496 5.94E-10 T 17-03-2017 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 SUPERFAMILY SSF53067 253 302 5.94E-10 T 17-03-2017 SHXM_RS46860 da3c9a724a520722042021745967fcbb 710 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 8 175 2.1E-28 T 17-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 Gene3D G3DSA:3.40.50.300 7 262 3.3E-82 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 Pfam PF00005 ABC transporter 37 188 1.4E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 SUPERFAMILY SSF52540 9 260 1.42E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 241 307 4.5E-16 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 240 331 4.9E-22 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 ProSitePatterns PS00211 ABC transporters family signature. 161 175 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33895 58542390a616988c5e87ca753eca8152 341 SMART SM00382 45 238 3.6E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS42530 f2b08ce57fe9f88e0c8e46e6da515d69 176 Gene3D G3DSA:2.60.40.420 51 174 6.2E-31 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS42530 f2b08ce57fe9f88e0c8e46e6da515d69 176 Pfam PF07731 Multicopper oxidase 68 170 3.5E-19 T 17-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 SHXM_RS42530 f2b08ce57fe9f88e0c8e46e6da515d69 176 SUPERFAMILY SSF49503 48 172 6.54E-27 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS42530 f2b08ce57fe9f88e0c8e46e6da515d69 176 ProSitePatterns PS00080 Multicopper oxidases signature 2. 157 168 - T 17-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 SHXM_RS36680 e55ffc95cc00f4ec3aa45736785e7f84 368 Pfam PF04055 Radical SAM superfamily 124 297 1.6E-16 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS36680 e55ffc95cc00f4ec3aa45736785e7f84 368 Hamap MF_01849 Dual-specificity RNA methyltransferase RlmN [rlmN]. 19 368 68.261 T 17-03-2017 IPR027492 Dual-specificity RNA methyltransferase RlmN GO:0030488|GO:0070475 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS36680 e55ffc95cc00f4ec3aa45736785e7f84 368 Gene3D G3DSA:3.20.20.70 120 334 3.5E-16 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS36680 e55ffc95cc00f4ec3aa45736785e7f84 368 SUPERFAMILY SSF102114 113 339 9.29E-17 T 17-03-2017 SHXM_RS36680 e55ffc95cc00f4ec3aa45736785e7f84 368 TIGRFAM TIGR00048 rRNA_mod_RlmN: 23S rRNA (adenine(2503)-C(2))-methyltransferase 20 367 6.1E-97 T 17-03-2017 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS36680 e55ffc95cc00f4ec3aa45736785e7f84 368 PIRSF PIRSF006004 14 368 9.4E-125 T 17-03-2017 IPR004383 Ribosomal RNA large subunit methyltransferase RlmN/Cfr GO:0005737|GO:0006364|GO:0008173 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 247 7.1E-71 T 17-03-2017 SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 SUPERFAMILY SSF51735 7 248 8.17E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 1.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 1.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 1.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 Gene3D G3DSA:3.40.50.720 7 249 4.5E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 1.0E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.0E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 1.0E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 1.0E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 1.0E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33730 143d8b67560e442b1099c456303cccde 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 1.0E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 SMART SM00382 52 251 4.7E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 SUPERFAMILY SSF52540 24 272 7.41E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 252 338 7.9E-20 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 ProSitePatterns PS00211 ABC transporters family signature. 174 188 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 253 314 9.3E-17 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 Pfam PF00005 ABC transporter 44 201 6.2E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33950 6c59f1094fea17e3ac62a91533a91337 357 Gene3D G3DSA:3.40.50.300 23 274 7.8E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 SUPERFAMILY SSF109604 122 293 7.53E-71 T 17-03-2017 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 SUPERFAMILY SSF81271 491 563 3.71E-21 T 17-03-2017 IPR012676 TGS-like KEGG: 00970+6.1.1.3 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 SMART SM00471 146 256 1.1E-12 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 SUPERFAMILY SSF81301 283 508 1.96E-63 T 17-03-2017 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Pfam PF13291 ACT domain 760 836 4.0E-17 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Gene3D G3DSA:3.30.70.260 762 834 5.6E-15 T 17-03-2017 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 SMART SM00954 338 448 2.1E-64 T 17-03-2017 IPR007685 RelA/SpoT GO:0015969 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Pfam PF04607 Region found in RelA / SpoT proteins 338 447 3.8E-37 T 17-03-2017 IPR007685 RelA/SpoT GO:0015969 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Pfam PF02824 TGS domain 504 563 1.2E-21 T 17-03-2017 IPR004095 TGS KEGG: 00970+6.1.1.3 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Gene3D G3DSA:3.30.460.10 281 427 4.4E-49 T 17-03-2017 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Pfam PF13328 HD domain 131 278 2.5E-51 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 Gene3D G3DSA:3.10.20.30 503 565 4.3E-23 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 TIGRFAM TIGR00691 spoT_relA: RelA/SpoT family protein 131 836 5.4E-258 T 17-03-2017 IPR004811 RelA/SpoT family GO:0015969 SHXM_RS12515 142bed5b3af7d05c0a3c39d34c9c9df3 843 SUPERFAMILY SSF55021 759 839 2.25E-15 T 17-03-2017 SHXM_RS48990 ec9007f95dd3e7b3c75ff973cba99368 303 SUPERFAMILY SSF48317 33 231 7.41E-12 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS48990 ec9007f95dd3e7b3c75ff973cba99368 303 Pfam PF01569 PAP2 superfamily 127 230 9.9E-11 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS48990 ec9007f95dd3e7b3c75ff973cba99368 303 Gene3D G3DSA:1.20.144.10 99 230 4.8E-8 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 248 327 2.1E-22 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 Pfam PF00005 ABC transporter 45 198 1.2E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 SUPERFAMILY SSF52540 25 269 1.6E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 Gene3D G3DSA:3.40.50.300 24 273 5.0E-82 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 SMART SM00382 54 248 8.5E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 ProSitePatterns PS00211 ABC transporters family signature. 171 185 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS45540 e4cbbc331832fff9987e3ca0df0ed4a5 356 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 250 318 1.8E-16 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Pfam PF02515 CoA-transferase family III 91 313 1.5E-25 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Pfam PF02515 CoA-transferase family III 356 740 4.5E-100 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Gene3D G3DSA:3.30.1540.10 196 270 1.7E-5 T 17-03-2017 SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Gene3D G3DSA:3.30.1540.10 589 672 2.9E-21 T 17-03-2017 SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 SUPERFAMILY SSF89796 353 746 1.44E-98 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 SUPERFAMILY SSF89796 2 324 6.8E-38 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Gene3D G3DSA:3.40.50.10540 353 582 1.2E-79 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Gene3D G3DSA:3.40.50.10540 2 187 3.9E-27 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Gene3D G3DSA:3.40.50.10540 673 746 1.2E-79 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47090 6bf4d0a0c8b25cf099eaedd2cfcb9233 750 Gene3D G3DSA:3.40.50.10540 271 322 3.9E-27 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 SUPERFAMILY SSF88659 343 416 3.74E-21 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Pfam PF04545 Sigma-70, region 4 438 491 2.8E-18 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 TIGRFAM TIGR02393 RpoD_Cterm: RNA polymerase sigma factor RpoD 266 502 8.6E-113 T 17-03-2017 IPR012760 RNA polymerase sigma factor RpoD, C-terminal GO:0003677|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 SUPERFAMILY SSF88946 202 340 7.46E-54 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Gene3D G3DSA:1.10.601.10 101 339 3.4E-70 T 17-03-2017 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 266 491 1.9E-36 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 294 307 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 463 489 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Gene3D G3DSA:1.10.10.10 343 394 3.8E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Pfam PF00140 Sigma-70 factor, region 1.2 205 238 7.8E-17 T 17-03-2017 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Hamap MF_00963 RNA polymerase sigma factor RpoD [rpoD]. 105 503 31.819 T 17-03-2017 IPR028630 RNA polymerase sigma factor RpoD GO:0006352|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 SUPERFAMILY SSF88659 401 502 2.4E-27 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Pfam PF04539 Sigma-70 region 3 349 425 1.0E-28 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Gene3D G3DSA:1.10.10.10 432 503 1.9E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 Pfam PF04542 Sigma-70 region 2 270 339 3.0E-22 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 PRINTS PR00046 Major sigma-70 factor signature 318 326 6.3E-29 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 PRINTS PR00046 Major sigma-70 factor signature 463 478 6.3E-29 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 PRINTS PR00046 Major sigma-70 factor signature 442 454 6.3E-29 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 PRINTS PR00046 Major sigma-70 factor signature 478 489 6.3E-29 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS37465 fa32873e4392622cc8943e5374751c28 503 PRINTS PR00046 Major sigma-70 factor signature 294 307 6.3E-29 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46920 8a1e0aa33c7bb783798bf352fc6c0896 381 SUPERFAMILY SSF110296 265 376 1.23E-6 T 17-03-2017 SHXM_RS46920 8a1e0aa33c7bb783798bf352fc6c0896 381 Gene3D G3DSA:2.130.10.140 250 378 1.2E-7 T 17-03-2017 SHXM_RS32020 5f323a5df4cb8dc784b4339500f2602b 268 PIRSF PIRSF028177 1 249 5.6E-59 T 17-03-2017 IPR016874 Tetracenomycin polyketide synthesis O-methyltransferase TcmP GO:0017000|GO:1901106 SHXM_RS32020 5f323a5df4cb8dc784b4339500f2602b 268 SUPERFAMILY SSF53335 4 253 8.31E-48 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS32020 5f323a5df4cb8dc784b4339500f2602b 268 Gene3D G3DSA:3.40.50.150 6 182 7.9E-23 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS32020 5f323a5df4cb8dc784b4339500f2602b 268 Pfam PF04072 Leucine carboxyl methyltransferase 13 166 5.1E-11 T 17-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 SHXM_RS10975 39d762a0dd327e16d6df99597f8f9f3b 276 Pfam PF03537 Glycoside-hydrolase family GH114 43 262 8.7E-47 T 17-03-2017 IPR004352 Glycoside-hydrolase family GH114, TIM-barrel domain SHXM_RS10975 39d762a0dd327e16d6df99597f8f9f3b 276 SUPERFAMILY SSF51445 43 245 1.85E-14 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 Pfam PF01965 DJ-1/PfpI family 7 172 1.6E-23 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 Pfam PF12833 Helix-turn-helix domain 233 311 9.9E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 Gene3D G3DSA:3.40.50.880 6 190 4.0E-48 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 SUPERFAMILY SSF52317 6 193 1.23E-43 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 SUPERFAMILY SSF46689 215 261 2.96E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 Gene3D G3DSA:1.10.10.60 211 264 2.7E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 SMART SM00342 227 310 1.1E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 Gene3D G3DSA:1.10.10.60 265 312 4.5E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02630 88aabe8fb8dedda0087a5a1ae9c747bc 315 SUPERFAMILY SSF46689 264 313 7.62E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 Pfam PF00571 CBS domain 223 272 3.3E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 Pfam PF00571 CBS domain 284 333 7.1E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 Gene3D G3DSA:3.10.580.10 216 332 9.2E-18 T 17-03-2017 SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 Pfam PF01595 Domain of unknown function DUF21 8 199 6.9E-43 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 SUPERFAMILY SSF54631 205 333 3.78E-25 T 17-03-2017 SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 SMART SM00116 225 273 0.0016 T 17-03-2017 IPR000644 CBS domain SHXM_RS08575 162890fd00600e4d56b184577cc8bf24 334 SMART SM00116 285 333 0.027 T 17-03-2017 IPR000644 CBS domain SHXM_RS45965 86161aef0f52f20b52c8c66e4c2bf98e 125 Gene3D G3DSA:1.10.10.10 16 80 1.3E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45965 86161aef0f52f20b52c8c66e4c2bf98e 125 Pfam PF03965 Penicillinase repressor 15 122 4.1E-21 T 17-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SHXM_RS45965 86161aef0f52f20b52c8c66e4c2bf98e 125 SUPERFAMILY SSF46785 17 122 4.69E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32510 1088cda3e58a5a4d82c8f5d60ed2b6a4 180 SUPERFAMILY SSF55729 9 146 5.85E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS32510 1088cda3e58a5a4d82c8f5d60ed2b6a4 180 Gene3D G3DSA:3.40.630.30 9 146 8.6E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS32510 1088cda3e58a5a4d82c8f5d60ed2b6a4 180 Pfam PF00583 Acetyltransferase (GNAT) family 55 135 4.5E-10 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 TIGRFAM TIGR01962 NuoD: NADH dehydrogenase (quinone), D subunit 41 445 1.3E-166 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 158 445 3.2E-106 T 17-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 78 89 - T 17-03-2017 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 SUPERFAMILY SSF56762 51 445 1.44E-116 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 Gene3D G3DSA:1.10.645.10 373 438 9.6E-66 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 Gene3D G3DSA:1.10.645.10 33 329 9.6E-66 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15680 7d807a23adeb95f2cf4a6a6c13814684 445 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 34 445 45.778 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 TIGRFAM TIGR01962 NuoD: NADH dehydrogenase (quinone), D subunit 41 445 1.3E-166 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 158 445 3.2E-106 T 17-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 78 89 - T 17-03-2017 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 SUPERFAMILY SSF56762 51 445 1.44E-116 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 Gene3D G3DSA:1.10.645.10 373 438 9.6E-66 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 Gene3D G3DSA:1.10.645.10 33 329 9.6E-66 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS15210 7d807a23adeb95f2cf4a6a6c13814684 445 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 34 445 45.778 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 Gene3D G3DSA:3.40.47.10 3 262 8.5E-69 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 Gene3D G3DSA:3.40.47.10 271 417 5.6E-53 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 SUPERFAMILY SSF53901 3 257 2.51E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 160 176 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 260 374 2.0E-32 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 SUPERFAMILY SSF53901 221 417 4.61E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3 252 5.1E-52 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS14525 ea6833234b8ad9c8e20cb3e706e121f7 422 SMART SM00825 Beta-ketoacyl synthase 5 408 2.4E-12 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF47336 3895 3982 1.2E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.50.720 3429 3524 1.3E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF55048 691 759 9.94E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF00698 Acyl transferase domain 2352 2637 1.9E-52 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF00698 Acyl transferase domain 567 890 6.3E-78 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.30.70.250 2480 2543 5.3E-6 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.30.70.250 691 758 6.4E-8 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF51735 1442 1678 7.88E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF08659 KR domain 1444 1622 3.4E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF08659 KR domain 3613 3792 1.5E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.366.10 759 874 2.2E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.366.10 2544 2637 1.8E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.366.10 566 687 2.2E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.366.10 2347 2475 1.8E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00826 939 1110 7.8E-73 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00826 2741 2914 5.9E-65 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1752 1767 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00829 3297 3603 3.8E-177 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF53901 31 398 2.13E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 283 5.7E-84 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1818 2068 8.6E-90 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1444 1624 8.5E-55 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3613 3793 3.4E-52 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF47336 1719 1833 9.29E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2354 2673 5.1E-117 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 568 871 1.3E-108 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF53901 1814 2189 2.31E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF52151 566 693 4.45E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF52151 760 865 4.45E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1981 1997 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.50.720 3612 3833 3.9E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.50.720 1443 1658 4.9E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 196 212 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF55048 2480 2544 7.85E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 3317 3372 5.5E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF52151 2350 2481 1.57E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF52151 2545 2638 1.57E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF50129 3311 3433 7.39E-24 T 17-03-2017 IPR011032 GroES-like SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.47.10 296 461 5.2E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.47.10 2081 2247 1.0E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00823 Phosphopantetheine attachment site 1725 1797 2.5E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00823 Phosphopantetheine attachment site 3902 3974 1.0E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.90.180.10 3311 3428 6.7E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF00550 Phosphopantetheine attachment site 3904 3970 7.7E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF00550 Phosphopantetheine attachment site 1727 1793 1.6E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2076 2193 5.5E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 291 407 2.1E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF14765 Polyketide synthase dehydratase 939 1230 6.5E-52 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF14765 Polyketide synthase dehydratase 2770 3035 6.7E-45 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3929 3944 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF101173 3 35 3.27E-8 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00825 Beta-ketoacyl synthase 37 461 2.2E-209 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM00825 Beta-ketoacyl synthase 1820 2246 2.9E-230 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF13602 Zinc-binding dehydrogenase 3471 3603 4.2E-18 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF51735 1240 1426 5.9E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF51735 3610 3861 1.46E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF51735 3395 3531 3.95E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SUPERFAMILY SSF51735 3047 3272 7.87E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.47.10 1820 2080 2.6E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:3.40.47.10 37 295 7.0E-85 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF08990 Erythronolide synthase docking 4 28 9.7E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 411 528 7.3E-12 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2196 2315 1.2E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM01294 3903 3970 6.0E-6 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 SMART SM01294 1726 1793 7.9E-6 T 17-03-2017 SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:1.10.1200.10 1723 1798 6.9E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06445 35d703f026a7fea191b25dbbf37cfa00 4061 Gene3D G3DSA:1.10.1200.10 3899 3975 4.3E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11715 c9882234bc3b714e66dfd5c990c00aec 251 SUPERFAMILY SSF56112 12 223 5.39E-27 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS11715 c9882234bc3b714e66dfd5c990c00aec 251 Gene3D G3DSA:3.90.1200.10 62 224 9.1E-25 T 17-03-2017 SHXM_RS11715 c9882234bc3b714e66dfd5c990c00aec 251 Pfam PF01636 Phosphotransferase enzyme family 17 203 8.5E-20 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 Pfam PF04545 Sigma-70, region 4 140 188 1.1E-12 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 SUPERFAMILY SSF88946 27 121 6.67E-21 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 Gene3D G3DSA:1.10.1740.10 30 110 2.2E-22 T 17-03-2017 SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 Gene3D G3DSA:1.10.10.10 129 193 3.2E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 63 95 - T 17-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 37 189 6.9E-24 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 SUPERFAMILY SSF88659 127 191 1.7E-12 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS23720 16034b33507e956214b1469cf5e989bc 198 Pfam PF04542 Sigma-70 region 2 40 108 2.0E-16 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS40020 1d72b70852f253521244c88c06102715 327 SUPERFAMILY SSF49493 149 233 4.06E-15 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS40020 1d72b70852f253521244c88c06102715 327 Gene3D G3DSA:2.60.260.20 225 301 1.8E-19 T 17-03-2017 SHXM_RS40020 1d72b70852f253521244c88c06102715 327 Pfam PF01556 DnaJ C terminal domain 155 301 2.2E-33 T 17-03-2017 IPR002939 Chaperone DnaJ, C-terminal SHXM_RS40020 1d72b70852f253521244c88c06102715 327 SUPERFAMILY SSF46565 3 113 9.55E-31 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 Gene3D G3DSA:1.10.287.110 2 70 5.3E-35 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 Gene3D G3DSA:1.10.287.110 107 139 5.3E-35 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 PRINTS PR00625 DnaJ domain signature 60 79 3.3E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 PRINTS PR00625 DnaJ domain signature 40 60 3.3E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 PRINTS PR00625 DnaJ domain signature 6 24 3.3E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 PRINTS PR00625 DnaJ domain signature 24 39 3.3E-22 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 ProSitePatterns PS00636 Nt-dnaJ domain signature. 45 64 - T 17-03-2017 IPR018253 DnaJ domain, conserved site SHXM_RS40020 1d72b70852f253521244c88c06102715 327 Pfam PF00226 DnaJ domain 4 65 3.2E-26 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS40020 1d72b70852f253521244c88c06102715 327 Gene3D G3DSA:2.60.260.20 150 222 6.4E-14 T 17-03-2017 SHXM_RS40020 1d72b70852f253521244c88c06102715 327 SUPERFAMILY SSF49493 227 312 1.57E-21 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS40020 1d72b70852f253521244c88c06102715 327 SMART SM00271 3 60 2.0E-29 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 SUPERFAMILY SSF51735 11 170 1.26E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 PIRSF PIRSF000103 4 296 5.7E-66 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 Gene3D G3DSA:3.40.50.720 9 171 3.6E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 ProSitePatterns PS00895 3-hydroxyisobutyrate dehydrogenase signature. 14 27 - T 17-03-2017 IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 SUPERFAMILY SSF48179 173 295 9.3E-36 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 174 293 2.1E-35 T 17-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 11 168 5.9E-40 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS02835 3fdefdd9a86db2e19da3077d613fe163 305 Gene3D G3DSA:1.10.1040.10 173 294 1.4E-44 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 Gene3D G3DSA:3.40.50.2300 59 172 5.5E-31 T 17-03-2017 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 SUPERFAMILY SSF53822 69 331 2.94E-54 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 SMART SM00354 9 79 7.5E-26 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 ProSitePatterns PS00356 LacI-type HTH domain signature. 12 30 - T 17-03-2017 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 Gene3D G3DSA:1.10.260.40 8 58 1.1E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 Pfam PF00356 Bacterial regulatory proteins, lacI family 11 56 3.7E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 Pfam PF13377 Periplasmic binding protein-like domain 173 331 1.8E-31 T 17-03-2017 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 SUPERFAMILY SSF47413 8 65 2.81E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 Gene3D G3DSA:3.40.50.2300 173 331 1.6E-44 T 17-03-2017 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 11 21 3.5E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS48745 1a87e2c0faac04c52f3abcb5f9be14a0 332 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 21 31 3.5E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS21630 c499f95d0e22d11afcd43e835668e7d8 400 TIGRFAM TIGR02210 rodA_shape: rod shape-determining protein RodA 34 396 2.3E-104 T 17-03-2017 IPR011923 Rod shape-determining protein RodA GO:0008360|GO:0016021 SHXM_RS21630 c499f95d0e22d11afcd43e835668e7d8 400 Pfam PF01098 Cell cycle protein 35 395 3.1E-92 T 17-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SHXM_RS21630 c499f95d0e22d11afcd43e835668e7d8 400 ProSitePatterns PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 354 378 - T 17-03-2017 IPR018365 Cell cycle, FtsW / RodA / SpoVE, conserved site GO:0007049|GO:0016021 SHXM_RS02330 251ccf781e513035d6abb197f20195a7 211 SUPERFAMILY SSF52518 11 199 2.32E-42 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS02330 251ccf781e513035d6abb197f20195a7 211 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 52 178 1.2E-17 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS02330 251ccf781e513035d6abb197f20195a7 211 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 71 90 - T 17-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SHXM_RS02330 251ccf781e513035d6abb197f20195a7 211 Gene3D G3DSA:3.40.50.970 9 197 6.9E-53 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Gene3D G3DSA:3.30.70.1400 59 146 5.6E-27 T 17-03-2017 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 TIGRFAM TIGR00528 gcvT: glycine cleavage system T protein 9 373 2.4E-108 T 17-03-2017 IPR006223 Glycine cleavage system T protein GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10|Reactome: R-HSA-6783984 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Gene3D G3DSA:2.40.30.110 291 367 5.4E-30 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Gene3D G3DSA:3.30.1360.120 9 58 4.3E-53 T 17-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Gene3D G3DSA:3.30.1360.120 147 241 4.3E-53 T 17-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Pfam PF01571 Aminomethyltransferase folate-binding domain 14 263 7.4E-91 T 17-03-2017 IPR006222 Glycine cleavage T-protein-like, N-terminal SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 271 367 4.4E-25 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 SUPERFAMILY SSF103025 9 282 1.18E-96 T 17-03-2017 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 SUPERFAMILY SSF101790 292 374 2.78E-24 T 17-03-2017 IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 Hamap MF_00259 Aminomethyltransferase [gcvT]. 7 373 44.848 T 17-03-2017 IPR022903 Glycine cleavage system T protein, bacteria GO:0004047|GO:0006546 KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS35960 e2bfe7244a08240a197c8934ceb78d63 375 PIRSF PIRSF006487 2 375 1.4E-99 T 17-03-2017 IPR028896 Aminomethyltransferase/Dimethylsulfonioproprionate demethylase DmdA KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10|Reactome: R-HSA-6783984 SHXM_RS19680 f74b09826fb6224d07c8782e1254b924 133 SUPERFAMILY SSF54593 10 118 6.23E-9 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS19680 f74b09826fb6224d07c8782e1254b924 133 Gene3D G3DSA:3.10.180.10 4 114 7.2E-10 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS10090 a6d4f94be5c7930a073162a7c150c52f 138 Pfam PF07811 TadE-like protein 16 56 5.0E-9 T 17-03-2017 IPR012495 TadE-like SHXM_RS30035 653d0b032290124834a134df71bf3199 208 Pfam PF03358 NADPH-dependent FMN reductase 21 164 2.0E-38 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS30035 653d0b032290124834a134df71bf3199 208 Gene3D G3DSA:3.40.50.360 10 204 4.8E-52 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS30035 653d0b032290124834a134df71bf3199 208 SUPERFAMILY SSF52218 17 202 1.13E-40 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS11020 566ff5cc71053f8a11e9805d2c9bd8f7 204 Gene3D G3DSA:2.40.260.10 59 186 5.3E-7 T 17-03-2017 IPR023365 Sortase domain SHXM_RS11020 566ff5cc71053f8a11e9805d2c9bd8f7 204 Pfam PF04203 Sortase family 62 199 3.4E-16 T 17-03-2017 IPR005754 Sortase family SHXM_RS11020 566ff5cc71053f8a11e9805d2c9bd8f7 204 SUPERFAMILY SSF63817 53 199 7.46E-15 T 17-03-2017 IPR023365 Sortase domain SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Pfam PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain 24 218 2.4E-19 T 17-03-2017 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Gene3D G3DSA:1.10.150.20 245 319 9.2E-32 T 17-03-2017 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 SUPERFAMILY SSF55257 14 48 2.35E-24 T 17-03-2017 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 SUPERFAMILY SSF55257 170 220 2.35E-24 T 17-03-2017 IPR009025 DNA-directed RNA polymerase, RBP11-like dimerisation domain GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Gene3D G3DSA:2.170.120.12 62 168 4.2E-45 T 17-03-2017 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 ProDom PD001179 RNA POLYMERASE ALPHA DNA-DIRECTED SUBUNIT CHAIN NUCLEOTIDYLTRANSFERASE TRANSFERASE TRANSCRIPTION TRANSCRIPTASE 257 311 2.0E-24 T 17-03-2017 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 TIGRFAM TIGR02027 rpoA: DNA-directed RNA polymerase, alpha subunit 19 310 4.8E-115 T 17-03-2017 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 SMART SM00662 18 225 1.3E-94 T 17-03-2017 IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Gene3D G3DSA:3.30.1360.10 171 217 2.6E-4 T 17-03-2017 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 SUPERFAMILY SSF47789 247 318 1.83E-23 T 17-03-2017 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 SUPERFAMILY SSF56553 48 169 4.97E-42 T 17-03-2017 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Pfam PF03118 Bacterial RNA polymerase, alpha chain C terminal domain 245 302 5.9E-26 T 17-03-2017 IPR011260 RNA polymerase, alpha subunit, C-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Gene3D G3DSA:3.30.1360.10 7 61 5.7E-11 T 17-03-2017 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Hamap MF_00059 DNA-directed RNA polymerase subunit alpha [rpoA]. 1 311 34.257 T 17-03-2017 IPR011773 DNA-directed RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31310 78e6e423c2dc9e4aed6d70f762389868 340 Pfam PF01000 RNA polymerase Rpb3/RpoA insert domain 57 149 5.8E-24 T 17-03-2017 IPR011262 DNA-directed RNA polymerase, insert domain GO:0003899|GO:0006351|GO:0046983 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 286 6.7E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF51735 978 1190 2.64E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF55048 692 758 1.12E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:3.40.47.10 299 465 1.8E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SMART SM01294 1491 1558 1.7E-5 T 17-03-2017 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1203 1382 1.3E-46 T 17-03-2017 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:3.40.50.720 1204 1406 3.1E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SMART SM00823 Phosphopantetheine attachment site 1490 1562 3.0E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF00698 Acyl transferase domain 567 880 4.7E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF53901 33 408 2.73E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF51735 1202 1434 1.53E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF52151 565 693 2.88E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF52151 759 857 2.88E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF00550 Phosphopantetheine attachment site 1492 1558 1.1E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 530 4.3E-18 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 568 867 1.7E-120 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF101173 5 36 9.68E-7 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:3.30.70.250 691 757 1.8E-8 T 17-03-2017 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:3.40.47.10 32 298 7.1E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF08659 KR domain 1203 1380 4.4E-50 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1517 1532 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SUPERFAMILY SSF47336 1482 1568 2.09E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 SMART SM00825 Beta-ketoacyl synthase 38 464 1.3E-224 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF08990 Erythronolide synthase docking 4 29 5.8E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:1.10.1200.10 1488 1563 2.4E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 411 3.4E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:3.40.366.10 758 868 2.0E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22165 2572b5d72fe6b867ef6cd89506fa7dee 1658 Gene3D G3DSA:3.40.366.10 565 687 2.0E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS10575 1f24a31f3b38177a7990a67149c60f36 542 SUPERFAMILY SSF75304 50 533 2.22E-114 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS10575 1f24a31f3b38177a7990a67149c60f36 542 Gene3D G3DSA:3.90.1300.10 50 534 2.0E-142 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS10575 1f24a31f3b38177a7990a67149c60f36 542 Pfam PF01425 Amidase 72 517 4.5E-90 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS40435 ccbf49d990f8fdec19178cab6d9d6335 115 SUPERFAMILY SSF54909 1 113 1.39E-18 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS40435 ccbf49d990f8fdec19178cab6d9d6335 115 Gene3D G3DSA:3.30.70.1060 1 113 2.4E-23 T 17-03-2017 SHXM_RS40435 ccbf49d990f8fdec19178cab6d9d6335 115 Pfam PF03795 YCII-related domain 1 113 1.5E-11 T 17-03-2017 IPR005545 YCII-related SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 Gene3D G3DSA:3.30.450.40 16 150 2.2E-8 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 SUPERFAMILY SSF46894 211 286 1.29E-16 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 SUPERFAMILY SSF55781 16 150 2.94E-10 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 SMART SM00421 223 280 8.6E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 Pfam PF00196 Bacterial regulatory proteins, luxR family 225 279 2.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 226 240 2.0E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 240 256 2.0E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 256 268 2.0E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 Gene3D G3DSA:1.10.10.10 215 285 4.9E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01150 b426b9fdc4c4d90c1fa9ec04616771ec 287 Pfam PF01590 GAF domain 55 150 5.4E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 SUPERFAMILY SSF55073 427 554 6.28E-37 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 SMART SM00086 283 325 3.3E-4 T 17-03-2017 IPR001610 PAC motif SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 SMART SM00267 325 560 1.8E-27 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 423 554 2.5E-30 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 SUPERFAMILY SSF55785 201 321 1.56E-18 T 17-03-2017 IPR000014 PAS domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 SUPERFAMILY SSF55781 12 191 1.35E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 Pfam PF00990 Diguanylate cyclase, GGDEF domain 426 554 4.1E-32 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 Gene3D G3DSA:3.30.450.40 10 201 5.6E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 SMART SM00091 213 283 2.0E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 209 331 3.6E-15 T 17-03-2017 IPR000014 PAS domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 Pfam PF13426 PAS domain 234 322 8.5E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 Gene3D G3DSA:3.30.70.270 430 555 1.5E-46 T 17-03-2017 SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 Gene3D G3DSA:3.30.70.270 338 363 1.5E-46 T 17-03-2017 SHXM_RS25910 98c5a77fb416b0d0257351fb72bb06f9 562 Gene3D G3DSA:3.30.450.20 205 322 3.3E-20 T 17-03-2017 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 Pfam PF00149 Calcineurin-like phosphoesterase 58 314 6.7E-6 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 SUPERFAMILY SSF55816 395 605 3.01E-49 T 17-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 Gene3D G3DSA:3.90.780.10 397 605 3.3E-50 T 17-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 Pfam PF02872 5'-nucleotidase, C-terminal domain 398 565 2.7E-39 T 17-03-2017 IPR008334 5'-Nucleotidase, C-terminal GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 PRINTS PR01607 Apyrase family signature 539 558 5.2E-19 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 PRINTS PR01607 Apyrase family signature 463 486 5.2E-19 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 PRINTS PR01607 Apyrase family signature 51 69 5.2E-19 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 PRINTS PR01607 Apyrase family signature 297 320 5.2E-19 T 17-03-2017 IPR006179 5'-Nucleotidase/apyrase GO:0009166|GO:0016787 Reactome: R-HSA-73621|Reactome: R-HSA-74259 SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 SUPERFAMILY SSF56300 47 395 2.4E-65 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS26240 0e111d76b169a5140c61ac4552152aec 606 Gene3D G3DSA:3.60.21.10 48 394 1.5E-75 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 Gene3D G3DSA:3.20.20.70 9 299 1.9E-81 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 PRINTS PR00146 Dihydrodipicolinate synthase signature 46 67 6.9E-9 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 PRINTS PR00146 Dihydrodipicolinate synthase signature 138 155 6.9E-9 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 PRINTS PR00146 Dihydrodipicolinate synthase signature 114 130 6.9E-9 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 PIRSF PIRSF001365 7 302 9.0E-68 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 SMART SM01130 10 302 3.3E-81 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 SUPERFAMILY SSF51569 9 297 1.67E-72 T 17-03-2017 SHXM_RS28720 dadb4612f5d0a373a69ac218e3dc6ea0 306 Pfam PF00701 Dihydrodipicolinate synthetase family 12 292 1.6E-43 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 SUPERFAMILY SSF56988 476 616 1.57E-42 T 17-03-2017 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 Gene3D G3DSA:3.90.182.10 473 616 7.3E-48 T 17-03-2017 IPR011658 PA14 domain SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 SUPERFAMILY SSF51445 56 371 1.96E-86 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 Pfam PF07691 PA14 domain 477 609 7.2E-28 T 17-03-2017 IPR011658 PA14 domain SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 PRINTS PR00741 Glycosyl hydrolase family 29 signature 223 239 1.1E-18 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 PRINTS PR00741 Glycosyl hydrolase family 29 signature 357 379 1.1E-18 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 PRINTS PR00741 Glycosyl hydrolase family 29 signature 140 156 1.1E-18 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 PRINTS PR00741 Glycosyl hydrolase family 29 signature 324 345 1.1E-18 T 17-03-2017 IPR016286 Alpha-L-fucosidase, metazoa-type GO:0004560|GO:0006004 KEGG: 00511+3.2.1.51 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 Pfam PF01120 Alpha-L-fucosidase 63 370 4.1E-87 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 SMART SM00758 474 611 1.4E-25 T 17-03-2017 IPR011658 PA14 domain SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 SMART SM00812 51 420 5.3E-92 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS38965 d623ca23e3259ef018e723563ebf440b 616 Gene3D G3DSA:3.20.20.80 59 371 6.4E-94 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 SUPERFAMILY SSF90123 21 328 1.83E-52 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 Gene3D G3DSA:1.20.1560.10 21 328 2.5E-51 T 17-03-2017 SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 Gene3D G3DSA:3.40.50.300 344 571 8.6E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 Pfam PF00005 ABC transporter 359 506 9.1E-23 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 Pfam PF00664 ABC transporter transmembrane region 31 299 3.3E-28 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 SUPERFAMILY SSF52540 337 576 1.11E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08255 b7f9b3beeda7edb793263bba0af35dd7 580 SMART SM00382 368 552 2.7E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS23650 1c46c3dd0094bc764ea619dacef1ad2c 299 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 12 175 1.6E-40 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS23650 1c46c3dd0094bc764ea619dacef1ad2c 299 SUPERFAMILY SSF56176 9 175 1.13E-39 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS23650 1c46c3dd0094bc764ea619dacef1ad2c 299 Gene3D G3DSA:3.30.465.10 62 175 2.3E-27 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS23650 1c46c3dd0094bc764ea619dacef1ad2c 299 Gene3D G3DSA:3.30.390.50 182 264 1.4E-4 T 17-03-2017 SHXM_RS23650 1c46c3dd0094bc764ea619dacef1ad2c 299 Gene3D G3DSA:3.30.43.10 15 55 2.0E-8 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.50.720 2485 2669 1.8E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.50.720 4033 4219 3.6E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00823 Phosphopantetheine attachment site 901 973 3.8E-22 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00823 Phosphopantetheine attachment site 4325 4397 4.8E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00823 Phosphopantetheine attachment site 2781 2853 1.8E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1158 1174 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF08659 KR domain 2485 2663 3.9E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF08659 KR domain 4033 4215 1.9E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.366.10 521 645 2.9E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.366.10 710 821 2.9E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.366.10 3394 3521 1.3E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.366.10 3586 3697 1.3E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.47.10 8 262 6.0E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.47.10 993 1257 3.7E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:1.10.1200.10 4323 4398 1.0E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:1.10.1200.10 2780 2852 6.2E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:1.10.1200.10 900 971 1.6E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF52151 525 645 3.4E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF52151 704 810 3.4E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF51735 2164 2340 1.02E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF47336 2779 2888 1.13E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.47.10 2875 3135 4.4E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF47336 4321 4403 1.15E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 2873 3123 3.2E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 11 250 9.6E-83 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 995 1245 3.5E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00825 Beta-ketoacyl synthase 997 1425 3.1E-232 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00825 Beta-ketoacyl synthase 12 429 8.9E-197 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00825 Beta-ketoacyl synthase 2875 3301 9.7E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF51735 4030 4295 2.42E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF53901 991 1369 5.25E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF47336 895 1010 2.22E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF55048 650 708 1.01E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF51735 2483 2716 6.18E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2808 2823 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 ProSitePatterns PS00012 Phosphopantetheine attachment site. 928 943 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3036 3052 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 ProSitePatterns PS00012 Phosphopantetheine attachment site. 4352 4367 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 258 375 4.9E-37 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3131 3248 2.0E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1253 1370 8.7E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM01294 2782 2849 1.7E-5 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM01294 902 969 6.6E-4 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1373 1495 1.1E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3251 3370 6.5E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 378 495 3.1E-17 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00698 Acyl transferase domain 526 834 1.9E-54 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00698 Acyl transferase domain 3402 3710 3.8E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00698 Acyl transferase domain 1532 1852 2.7E-89 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF53901 2869 3245 4.91E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.47.10 263 430 3.6E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.47.10 3136 3300 2.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.47.10 1258 1426 1.9E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF52151 1724 1820 1.02E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF52151 1530 1659 1.02E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF55048 3526 3587 7.19E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00550 Phosphopantetheine attachment site 916 969 2.2E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00550 Phosphopantetheine attachment site 2783 2849 5.1E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF00550 Phosphopantetheine attachment site 4330 4393 5.4E-7 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF55048 1657 1719 8.37E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF51735 3806 4021 7.09E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.30.70.250 3525 3581 1.8E-5 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.30.70.250 649 707 1.1E-5 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.30.70.250 1657 1715 1.9E-6 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF52151 3580 3686 1.26E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF52151 3400 3521 1.26E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Pfam PF14765 Polyketide synthase dehydratase 1902 2152 2.4E-19 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00826 1902 2064 7.2E-53 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 527 817 8.6E-120 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1534 1832 2.4E-120 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3403 3693 2.0E-121 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4033 4216 1.8E-58 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2485 2665 1.3E-61 T 17-03-2017 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 SUPERFAMILY SSF53901 7 368 9.98E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.366.10 1723 1844 1.5E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07240 db4554f2a68db860ee2215b9b9693a42 4479 Gene3D G3DSA:3.40.366.10 1520 1654 1.5E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS37525 47c1f8ec7621926b87c6b7159706df82 264 SUPERFAMILY SSF51261 88 257 3.82E-43 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS37525 47c1f8ec7621926b87c6b7159706df82 264 Pfam PF01551 Peptidase family M23 156 253 1.0E-29 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS37525 47c1f8ec7621926b87c6b7159706df82 264 Gene3D G3DSA:2.70.70.10 107 258 1.6E-43 T 17-03-2017 SHXM_RS24275 07d34243fd1bead3de1fb783df87a121 484 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 101 253 3.5E-48 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24275 07d34243fd1bead3de1fb783df87a121 484 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 101 253 2.4E-49 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24275 07d34243fd1bead3de1fb783df87a121 484 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 363 448 6.1E-14 T 17-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain SHXM_RS43400 374d57d9f435dfedc384529e9f3f1916 359 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 93 107 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS43400 374d57d9f435dfedc384529e9f3f1916 359 SUPERFAMILY SSF48576 33 357 4.16E-77 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS43400 374d57d9f435dfedc384529e9f3f1916 359 Pfam PF00348 Polyprenyl synthetase 42 304 1.2E-58 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS43400 374d57d9f435dfedc384529e9f3f1916 359 Gene3D G3DSA:1.10.600.10 16 358 5.0E-88 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS43400 374d57d9f435dfedc384529e9f3f1916 359 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 237 249 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 Gene3D G3DSA:3.20.20.100 5 272 2.0E-104 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 PRINTS PR00069 Aldo-keto reductase signature 37 61 3.4E-48 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 PRINTS PR00069 Aldo-keto reductase signature 197 221 3.4E-48 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 PRINTS PR00069 Aldo-keto reductase signature 125 142 3.4E-48 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 PRINTS PR00069 Aldo-keto reductase signature 93 111 3.4E-48 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 PRINTS PR00069 Aldo-keto reductase signature 159 188 3.4E-48 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 PIRSF PIRSF000097 2 270 3.8E-86 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 125 142 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 Pfam PF00248 Aldo/keto reductase family 18 262 6.8E-52 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 SUPERFAMILY SSF51430 6 268 4.71E-95 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS14320 100359ad078219faf2386625e596d3a8 276 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 230 245 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS42900 09db336fb6eeb6124c63eb59f9f78bb2 295 SUPERFAMILY SSF56601 55 286 4.91E-37 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS42900 09db336fb6eeb6124c63eb59f9f78bb2 295 Gene3D G3DSA:3.40.710.10 55 284 7.8E-31 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS42900 09db336fb6eeb6124c63eb59f9f78bb2 295 Pfam PF13354 Beta-lactamase enzyme family 123 239 1.0E-11 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 Pfam PF01494 FAD binding domain 11 365 1.1E-108 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 171 186 1.0E-38 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 301 316 1.0E-38 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 352 368 1.0E-38 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 334 352 1.0E-38 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 12 34 1.0E-38 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 316 332 1.0E-38 T 17-03-2017 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 Gene3D G3DSA:3.50.50.60 289 366 8.1E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 Gene3D G3DSA:3.50.50.60 10 76 8.1E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 Gene3D G3DSA:3.50.50.60 113 197 8.1E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 SUPERFAMILY SSF51905 11 192 4.43E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14510 9d7a3963bf9e7a9ff997789a84e382c8 547 SUPERFAMILY SSF51905 288 369 4.43E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 Pfam PF01494 FAD binding domain 3 375 7.1E-67 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 361 377 4.1E-40 T 17-03-2017 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 310 325 4.1E-40 T 17-03-2017 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 325 341 4.1E-40 T 17-03-2017 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 4.1E-40 T 17-03-2017 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 188 203 4.1E-40 T 17-03-2017 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 343 361 4.1E-40 T 17-03-2017 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 Gene3D G3DSA:3.50.50.60 298 382 1.6E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 Gene3D G3DSA:3.50.50.60 130 214 1.6E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 Gene3D G3DSA:3.50.50.60 3 69 1.6E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 SUPERFAMILY SSF51905 306 399 7.89E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 SUPERFAMILY SSF51905 124 209 7.89E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48815 b81e98c78902fd27c989a30059bc6913 530 SUPERFAMILY SSF51905 2 87 7.89E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46490 7684c3c9d0fa0ac09cba49e2eb2a69fd 151 SMART SM00347 26 127 2.5E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS46490 7684c3c9d0fa0ac09cba49e2eb2a69fd 151 Gene3D G3DSA:1.10.10.10 8 141 1.0E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46490 7684c3c9d0fa0ac09cba49e2eb2a69fd 151 ProSitePatterns PS01117 MarR-type HTH domain signature. 66 100 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS46490 7684c3c9d0fa0ac09cba49e2eb2a69fd 151 SUPERFAMILY SSF46785 11 145 8.91E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46490 7684c3c9d0fa0ac09cba49e2eb2a69fd 151 Pfam PF12802 MarR family 36 91 1.0E-10 T 17-03-2017 SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 TIGRFAM TIGR02961 allantoicase: allantoicase 34 362 1.1E-122 T 17-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 Gene3D G3DSA:2.60.120.260 213 366 5.2E-43 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 Gene3D G3DSA:2.60.120.260 27 206 4.1E-57 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 Hamap MF_00813 Probable allantoicase [alc]. 23 365 48.888 T 17-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 Pfam PF03561 Allantoicase repeat 225 362 5.2E-38 T 17-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 Pfam PF03561 Allantoicase repeat 43 202 5.0E-45 T 17-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 PIRSF PIRSF016516 21 366 4.8E-95 T 17-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 SUPERFAMILY SSF49785 210 365 3.87E-43 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS39005 96aa655b05f7396791051f2bfcdc0584 382 SUPERFAMILY SSF49785 25 206 2.04E-53 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 SMART SM00946 409 471 0.0022 T 17-03-2017 IPR016061 Proline-tRNA ligase, class II, C-terminal GO:0000166|GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-6782315 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 PRINTS PR01046 Prolyl-tRNA synthetase signature 106 117 8.0E-6 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 PRINTS PR01046 Prolyl-tRNA synthetase signature 145 156 8.0E-6 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 PRINTS PR01046 Prolyl-tRNA synthetase signature 65 83 8.0E-6 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 PRINTS PR01046 Prolyl-tRNA synthetase signature 136 144 8.0E-6 T 17-03-2017 IPR002316 Proline-tRNA ligase, class IIa GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-379726 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 103 271 6.7E-13 T 17-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 SUPERFAMILY SSF52954 278 400 9.82E-25 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 TIGRFAM TIGR00408 proS_fam_I: proline--tRNA ligase 9 415 1.6E-141 T 17-03-2017 IPR004499 Proline-tRNA ligase, class IIa, archaeal-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-6782315 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 Hamap MF_01571 Proline--tRNA ligase [proS]. 7 471 39.767 T 17-03-2017 IPR004499 Proline-tRNA ligase, class IIa, archaeal-type GO:0004827|GO:0005524|GO:0005737|GO:0006433 KEGG: 00970+6.1.1.15|Reactome: R-HSA-2408517|Reactome: R-HSA-379716|Reactome: R-HSA-6782315 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 Gene3D G3DSA:3.40.50.800 284 400 4.9E-29 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 Gene3D G3DSA:3.30.930.10 5 283 9.6E-106 T 17-03-2017 SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 Pfam PF03129 Anticodon binding domain 290 375 2.3E-12 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS36560 da3185146ec94bba1d698ad26f1ea168 471 SUPERFAMILY SSF55681 12 277 1.23E-72 T 17-03-2017 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 SMART SM00354 8 75 5.0E-21 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 Pfam PF13377 Periplasmic binding protein-like domain 177 339 8.4E-32 T 17-03-2017 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 Pfam PF00356 Bacterial regulatory proteins, lacI family 11 53 6.7E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 Gene3D G3DSA:1.10.260.40 9 53 7.8E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 Gene3D G3DSA:3.40.50.2300 58 182 4.0E-33 T 17-03-2017 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 ProSitePatterns PS00356 LacI-type HTH domain signature. 11 29 - T 17-03-2017 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 SUPERFAMILY SSF47413 10 55 1.72E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 SUPERFAMILY SSF53822 65 343 3.14E-66 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS19260 16b2d27ff2db4978c4026da5132140a7 355 Gene3D G3DSA:3.40.50.2300 183 320 1.7E-44 T 17-03-2017 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 SMART SM00304 176 228 9.3E-13 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 337 433 1.4E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 SUPERFAMILY SSF47384 213 282 2.75E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 Pfam PF00512 His Kinase A (phospho-acceptor) domain 231 279 1.2E-7 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 Gene3D G3DSA:3.30.565.10 293 433 6.1E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 SUPERFAMILY SSF55874 291 431 2.23E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 PRINTS PR00344 Bacterial sensor protein C-terminal signature 395 413 3.0E-7 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 PRINTS PR00344 Bacterial sensor protein C-terminal signature 367 381 3.0E-7 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 SMART SM00387 330 435 2.6E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 Pfam PF00672 HAMP domain 157 224 2.7E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 Gene3D G3DSA:1.10.287.130 219 280 1.2E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 SMART SM00388 229 287 8.5E-5 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22810 bec1a4a68ed64ac4bc8402a5181656ed 464 SUPERFAMILY SSF158472 177 225 1.44E-5 T 17-03-2017 SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 Gene3D G3DSA:3.40.50.1820 222 298 9.0E-29 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 Gene3D G3DSA:3.40.50.1820 58 182 9.0E-29 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 105 120 3.4E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 150 163 3.4E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 PRINTS PR00111 Alpha/beta hydrolase fold signature 164 177 3.4E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 SUPERFAMILY SSF53474 58 298 1.37E-28 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26710 f4a49cf30ec9282918992c5b6eaaa9ad 307 Pfam PF00561 alpha/beta hydrolase fold 80 182 9.5E-14 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00385 P450 superfamily signature 276 287 3.9E-9 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00385 P450 superfamily signature 241 258 3.9E-9 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00385 P450 superfamily signature 344 353 3.9E-9 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00385 P450 superfamily signature 353 364 3.9E-9 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 Pfam PF00067 Cytochrome P450 84 255 3.5E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 Pfam PF00067 Cytochrome P450 273 373 4.4E-26 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 Gene3D G3DSA:1.10.630.10 8 404 6.2E-117 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 92 103 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 194 216 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 322 337 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 139 155 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 156 171 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 276 287 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 353 364 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 294 321 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 PRINTS PR00359 B-class P450 signature 344 353 6.6E-51 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 SUPERFAMILY SSF48264 16 404 1.31E-92 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45330 dd2618f71cb9eebc6afd44ff362d9bd7 404 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 346 355 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 Pfam PF00154 recA bacterial DNA recombination protein 8 269 2.9E-143 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 SUPERFAMILY SSF52540 5 268 3.82E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 Hamap MF_00268 Protein RecA [recA]. 6 330 52.977 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 Gene3D G3DSA:3.30.250.10 269 327 1.5E-29 T 17-03-2017 IPR023400 DNA recombination and repair protein RecA, C-terminal SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 SUPERFAMILY SSF54752 269 327 1.7E-21 T 17-03-2017 IPR023400 DNA recombination and repair protein RecA, C-terminal SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 Gene3D G3DSA:3.40.50.300 29 268 6.2E-88 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 PRINTS PR00142 RecA protein signature 94 123 1.5E-85 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 PRINTS PR00142 RecA protein signature 298 315 1.5E-85 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 PRINTS PR00142 RecA protein signature 128 157 1.5E-85 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 PRINTS PR00142 RecA protein signature 166 195 1.5E-85 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 PRINTS PR00142 RecA protein signature 244 273 1.5E-85 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 PRINTS PR00142 RecA protein signature 211 239 1.5E-85 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 SMART SM00382 58 229 1.9E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 TIGRFAM TIGR02012 tigrfam_recA: protein RecA 5 325 3.6E-175 T 17-03-2017 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SHXM_RS37240 1e5fdac476a2d76889509ac560546b23 379 ProSitePatterns PS00321 recA signature. 214 222 - T 17-03-2017 IPR020584 DNA recombination/repair protein RecA, conserved site GO:0003677|GO:0005524|GO:0006259|GO:0008094 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 Gene3D G3DSA:3.75.10.10 151 407 1.3E-126 T 17-03-2017 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 Gene3D G3DSA:3.75.10.10 2 66 1.3E-126 T 17-03-2017 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 Hamap MF_00242 Arginine deiminase [arcA]. 1 407 42.086 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 Pfam PF02274 Amidinotransferase 17 404 3.7E-86 T 17-03-2017 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PRINTS PR01466 Bacterial arginine deiminase signature 386 404 6.0E-47 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PRINTS PR01466 Bacterial arginine deiminase signature 343 360 6.0E-47 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PRINTS PR01466 Bacterial arginine deiminase signature 151 169 6.0E-47 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PRINTS PR01466 Bacterial arginine deiminase signature 1 20 6.0E-47 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PRINTS PR01466 Bacterial arginine deiminase signature 363 377 6.0E-47 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PRINTS PR01466 Bacterial arginine deiminase signature 179 194 6.0E-47 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 SUPERFAMILY SSF55909 2 407 1.96E-125 T 17-03-2017 SHXM_RS37975 b6eebabc7b4471dc96ed8ac054f95171 409 PIRSF PIRSF006356 1 407 2.6E-148 T 17-03-2017 IPR003876 Arginine deiminase GO:0006527|GO:0016990 KEGG: 00220+3.5.3.6|MetaCyc: PWY-4981 SHXM_RS25175 61b499eb3597825e4cb206741ebfe4f4 395 Pfam PF03738 Glutathionylspermidine synthase preATP-grasp 12 394 6.7E-137 T 17-03-2017 IPR005494 Glutathionylspermidine synthase, pre-ATP-grasp-like domain SHXM_RS25175 61b499eb3597825e4cb206741ebfe4f4 395 SUPERFAMILY SSF52440 179 293 1.01E-33 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS25175 61b499eb3597825e4cb206741ebfe4f4 395 SUPERFAMILY SSF56059 280 393 4.24E-73 T 17-03-2017 SHXM_RS25175 61b499eb3597825e4cb206741ebfe4f4 395 SUPERFAMILY SSF56059 1 170 4.24E-73 T 17-03-2017 SHXM_RS23065 324a01adc3a14bf1c4dd901a8ceb66b4 84 ProDom PD000887 CARRIER ACYL PHOSPHOPANTETHEINE ACP ACID FATTY BIOSYNTHESIS LIPID SYNTHESIS CHLOROPLAST 39 78 0.002 T 17-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS23065 324a01adc3a14bf1c4dd901a8ceb66b4 84 Pfam PF00550 Phosphopantetheine attachment site 11 74 1.2E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23065 324a01adc3a14bf1c4dd901a8ceb66b4 84 SMART SM01294 11 78 0.001 T 17-03-2017 SHXM_RS23065 324a01adc3a14bf1c4dd901a8ceb66b4 84 SUPERFAMILY SSF47336 11 82 3.53E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23065 324a01adc3a14bf1c4dd901a8ceb66b4 84 Gene3D G3DSA:1.10.1200.10 11 83 4.5E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS44355 dda844bfabc92570af265ec9c9654825 543 SMART SM00857 25 172 5.5E-19 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS44355 dda844bfabc92570af265ec9c9654825 543 Gene3D G3DSA:3.40.50.1390 25 153 2.3E-16 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS44355 dda844bfabc92570af265ec9c9654825 543 Pfam PF07508 Recombinase 207 309 1.6E-8 T 17-03-2017 IPR011109 DNA-binding recombinase domain GO:0000150|GO:0003677 SHXM_RS44355 dda844bfabc92570af265ec9c9654825 543 SUPERFAMILY SSF53041 25 171 3.14E-20 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS44355 dda844bfabc92570af265ec9c9654825 543 Pfam PF00239 Resolvase, N terminal domain 25 170 4.2E-19 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS05670 1bde107b2396dffd524726f6381c89ae 149 SUPERFAMILY SSF46785 3 137 7.76E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05670 1bde107b2396dffd524726f6381c89ae 149 Pfam PF02082 Transcriptional regulator 5 83 2.1E-18 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS05670 1bde107b2396dffd524726f6381c89ae 149 Gene3D G3DSA:1.10.10.10 3 141 1.3E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42355 b85f86723294920939c00f5f0cb94617 284 Gene3D G3DSA:3.40.50.150 95 247 7.3E-16 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS42355 b85f86723294920939c00f5f0cb94617 284 Pfam PF13649 Methyltransferase domain 97 181 2.2E-7 T 17-03-2017 SHXM_RS42355 b85f86723294920939c00f5f0cb94617 284 PIRSF PIRSF018249 1 283 4.9E-90 T 17-03-2017 IPR016718 rRNA (guanine-N1-)-methyltransferase A, predicted GO:0008168 SHXM_RS42355 b85f86723294920939c00f5f0cb94617 284 SUPERFAMILY SSF53335 11 214 3.19E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44290 df0547b67f216ed426e7916ab005ccbb 189 Gene3D G3DSA:3.40.50.300 2 168 7.6E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44290 df0547b67f216ed426e7916ab005ccbb 189 SUPERFAMILY SSF52540 2 167 4.65E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33450 2fd0817ba44181364f98fbc1df294c06 580 Pfam PF07811 TadE-like protein 463 505 1.0E-5 T 17-03-2017 IPR012495 TadE-like SHXM_RS33450 2fd0817ba44181364f98fbc1df294c06 580 SUPERFAMILY SSF52172 3 130 1.01E-8 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS33450 2fd0817ba44181364f98fbc1df294c06 580 SUPERFAMILY SSF52540 151 386 1.65E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33450 2fd0817ba44181364f98fbc1df294c06 580 Gene3D G3DSA:3.40.50.2300 3 128 9.3E-8 T 17-03-2017 SHXM_RS33450 2fd0817ba44181364f98fbc1df294c06 580 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 153 336 2.0E-23 T 17-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SHXM_RS33450 2fd0817ba44181364f98fbc1df294c06 580 Gene3D G3DSA:3.40.50.300 150 386 3.0E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 PIRSF PIRSF000148 1 340 1.7E-106 T 17-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 SMART SM00859 2 117 1.3E-38 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 ProSitePatterns PS01103 Aspartate-semialdehyde dehydrogenase signature. 240 254 - T 17-03-2017 IPR000319 Aspartate-semialdehyde dehydrogenase, conserved site GO:0004073|GO:0006520|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 Gene3D G3DSA:3.40.50.720 1 138 7.4E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 Gene3D G3DSA:3.30.360.10 139 319 2.9E-67 T 17-03-2017 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 TIGRFAM TIGR01296 asd_B: aspartate-semialdehyde dehydrogenase 2 337 2.1E-125 T 17-03-2017 IPR005986 Aspartate-semialdehyde dehydrogenase, beta-type GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 SUPERFAMILY SSF55347 126 324 1.75E-58 T 17-03-2017 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 2 113 1.1E-30 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 Hamap MF_02121 Aspartate-semialdehyde dehydrogenase [asd]. 1 337 33.127 T 17-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 SUPERFAMILY SSF51735 1 153 5.14E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21850 b3c431d0053d7a7b6de6c92d8f7fd8a1 341 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 136 323 8.1E-51 T 17-03-2017 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 SUPERFAMILY SSF47413 30 96 3.49E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 Pfam PF13560 Helix-turn-helix domain 32 88 8.6E-17 T 17-03-2017 SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 SUPERFAMILY SSF51182 94 202 8.65E-21 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 Pfam PF07883 Cupin domain 138 200 5.3E-13 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 Gene3D G3DSA:2.60.120.10 101 202 5.6E-17 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 Gene3D G3DSA:1.10.260.40 31 100 2.0E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39050 204924a8f3b185ee5eef5ec3d96ec6ab 225 SMART SM00530 34 89 7.3E-17 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 SMART SM00843 863 927 1.1E-30 T 17-03-2017 IPR018541 FtsK gamma domain SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 SUPERFAMILY SSF46785 864 929 2.04E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 SUPERFAMILY SSF52540 536 835 5.52E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 Pfam PF09397 Ftsk gamma domain 867 924 1.4E-22 T 17-03-2017 IPR018541 FtsK gamma domain SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 Gene3D G3DSA:3.40.50.300 537 829 1.5E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 Pfam PF01580 FtsK/SpoIIIE family 565 763 2.5E-54 T 17-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SHXM_RS37160 0d099ab77b71b5a7d185ea9036f4c530 942 SMART SM00382 598 796 3.7E-4 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 Gene3D G3DSA:3.20.20.70 40 313 8.3E-128 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 SUPERFAMILY SSF51011 321 407 7.2E-21 T 17-03-2017 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 Gene3D G3DSA:2.60.40.1180 314 408 1.8E-26 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 Pfam PF16499 Alpha galactosidase A 49 384 5.7E-97 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 PRINTS PR00740 Glycosyl hydrolase family 27 signature 254 273 6.2E-55 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 PRINTS PR00740 Glycosyl hydrolase family 27 signature 275 296 6.2E-55 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 PRINTS PR00740 Glycosyl hydrolase family 27 signature 44 63 6.2E-55 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 PRINTS PR00740 Glycosyl hydrolase family 27 signature 160 177 6.2E-55 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 PRINTS PR00740 Glycosyl hydrolase family 27 signature 82 97 6.2E-55 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 PRINTS PR00740 Glycosyl hydrolase family 27 signature 187 205 6.2E-55 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 SUPERFAMILY SSF51445 40 319 2.95E-98 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS07490 ee2af1baa2e0ef2c62ba0a0cbe543621 409 ProSitePatterns PS00512 Alpha-galactosidase signature. 87 103 - T 17-03-2017 IPR000111 Glycoside hydrolase family 27/36, conserved site GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 PIRSF PIRSF002599 1 67 1.5E-26 T 17-03-2017 IPR012156 Cold shock, CspA GO:0003676 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 PRINTS PR00050 Cold shock protein signature 4 19 7.9E-18 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 PRINTS PR00050 Cold shock protein signature 25 34 7.9E-18 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 PRINTS PR00050 Cold shock protein signature 40 58 7.9E-18 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 SMART SM00357 3 67 4.5E-32 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 SUPERFAMILY SSF50249 1 66 3.21E-25 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 65 1.8E-31 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS22570 9878b27ad3f53a5860785ed805db6144 67 Gene3D G3DSA:2.40.50.140 1 65 5.5E-31 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 SUPERFAMILY SSF54909 63 142 6.57E-19 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 Pfam PF13412 Winged helix-turn-helix DNA-binding 1 48 1.3E-20 T 17-03-2017 SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 SMART SM00344 1 110 7.0E-46 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 SUPERFAMILY SSF46785 1 60 6.84E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 Gene3D G3DSA:3.30.70.920 54 137 2.9E-27 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 1.3E-18 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 1.3E-18 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 1.3E-18 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 Gene3D G3DSA:1.10.10.10 2 52 1.0E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01780 4b6f71e8ca4f540c7af024629c173c68 147 Pfam PF01037 Lrp/AsnC ligand binding domain 68 141 1.1E-21 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS14635 2abded0c8b5914af7165fd361dc4b6e6 271 Gene3D G3DSA:3.40.50.150 7 265 4.9E-46 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14635 2abded0c8b5914af7165fd361dc4b6e6 271 Pfam PF13847 Methyltransferase domain 38 148 8.2E-29 T 17-03-2017 IPR025714 Methyltransferase domain SHXM_RS14635 2abded0c8b5914af7165fd361dc4b6e6 271 SUPERFAMILY SSF53335 8 224 1.08E-45 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS49545 4a361e3b0369405f96e4b0dd7668c4ef 270 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 83 261 2.1E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49545 4a361e3b0369405f96e4b0dd7668c4ef 270 Gene3D G3DSA:1.10.3720.10 5 257 9.1E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49545 4a361e3b0369405f96e4b0dd7668c4ef 270 SUPERFAMILY SSF161098 7 270 7.46E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 TIGRFAM TIGR01427 PTS_IIC_fructo: PTS system, Fru family, IIC component 331 670 2.0E-113 T 17-03-2017 IPR006327 Phosphotransferase system, fructose IIC component GO:0005351|GO:0008982|GO:0009401|GO:0016021 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 TIGRFAM TIGR00848 fruA: PTS system, fructose subfamily, IIA component 5 130 5.5E-31 T 17-03-2017 IPR004715 Phosphotransferase system, IIA component fructose subfamily GO:0008982|GO:0009401|GO:0016021 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 TIGRFAM TIGR00829 FRU: PTS system, Fru family, IIB component 204 286 5.9E-26 T 17-03-2017 IPR003353 Phosphotransferase system, fructose-specific IIB subunit GO:0009401|GO:0022877 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 Pfam PF02378 Phosphotransferase system, EIIC 339 615 1.0E-15 T 17-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 4 143 9.0E-32 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 Gene3D G3DSA:3.40.50.2300 201 300 2.9E-37 T 17-03-2017 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 Pfam PF02302 PTS system, Lactose/Cellobiose specific IIB subunit 205 294 3.6E-18 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 Gene3D G3DSA:3.40.930.10 1 146 6.7E-42 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 SUPERFAMILY SSF52794 202 300 1.13E-30 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS32370 dfd8d9d16f72d46148b151f356011cad 705 SUPERFAMILY SSF55804 2 144 5.62E-33 T 17-03-2017 IPR016152 Phosphotransferase/anion transporter GO:0005215|GO:0006810 Reactome: R-HSA-425381 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 TIGRFAM TIGR03217 4OH_2_O_val_ald: 4-hydroxy-2-oxovalerate aldolase 19 348 1.4E-165 T 17-03-2017 IPR017629 4-hydroxy-2-oxovalerate aldolase GO:0008701|GO:0019439 KEGG: 00360+4.1.3.39|KEGG: 00362+4.1.3.39|KEGG: 00621+4.1.3.39|KEGG: 00622+4.1.3.39|MetaCyc: PWY-5162 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 Hamap MF_01656 4-hydroxy-2-oxovalerate aldolase [mhpE]. 1 354 204.699 T 17-03-2017 IPR017629 4-hydroxy-2-oxovalerate aldolase GO:0008701|GO:0019439 KEGG: 00360+4.1.3.39|KEGG: 00362+4.1.3.39|KEGG: 00621+4.1.3.39|KEGG: 00622+4.1.3.39|MetaCyc: PWY-5162 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 Gene3D G3DSA:1.10.8.60 288 350 7.7E-33 T 17-03-2017 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 Pfam PF00682 HMGL-like 19 277 5.1E-61 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 Pfam PF07836 DmpG-like communication domain 287 347 3.6E-31 T 17-03-2017 IPR012425 DmpG-like communication GO:0016833|GO:0019439 KEGG: 00360+4.1.3.39|KEGG: 00362+4.1.3.39|KEGG: 00621+4.1.3.39|KEGG: 00622+4.1.3.39|MetaCyc: PWY-5162 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 Gene3D G3DSA:3.20.20.70 16 276 1.6E-50 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 ProDom PD005364 ALDOLASE 4-HYDROXY-2-OXOVALERATE LYASE PYRUVATE 4.1.3.- PLASMID HMG-COA LYASE-LIKE TRANSFERASE HOA 286 346 2.0E-23 T 17-03-2017 IPR012425 DmpG-like communication GO:0016833|GO:0019439 KEGG: 00360+4.1.3.39|KEGG: 00362+4.1.3.39|KEGG: 00621+4.1.3.39|KEGG: 00622+4.1.3.39|MetaCyc: PWY-5162 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 SUPERFAMILY SSF89000 301 349 3.61E-17 T 17-03-2017 SHXM_RS11260 d340d1e8792d2dc274f5179966dd4eef 354 SUPERFAMILY SSF51569 16 288 2.56E-61 T 17-03-2017 SHXM_RS11690 ae2261aa3d6f7ece4986395738c2ed3f 319 SUPERFAMILY SSF161098 78 307 6.8E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11690 ae2261aa3d6f7ece4986395738c2ed3f 319 SUPERFAMILY SSF160964 30 64 7.72E-6 T 17-03-2017 SHXM_RS11690 ae2261aa3d6f7ece4986395738c2ed3f 319 Gene3D G3DSA:1.20.58.370 31 64 3.0E-6 T 17-03-2017 SHXM_RS11690 ae2261aa3d6f7ece4986395738c2ed3f 319 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 111 307 2.3E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11690 ae2261aa3d6f7ece4986395738c2ed3f 319 Gene3D G3DSA:1.10.3720.10 89 316 2.8E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38590 740c263eca0b21949b2277818ebf2c39 283 Gene3D G3DSA:1.10.3720.10 8 270 2.6E-69 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38590 740c263eca0b21949b2277818ebf2c39 283 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 94 272 2.1E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38590 740c263eca0b21949b2277818ebf2c39 283 SUPERFAMILY SSF161098 8 282 9.94E-71 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43445 ecd07df58ad1ad3255d69921a58be716 151 SMART SM00100 7 125 3.9E-8 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS43445 ecd07df58ad1ad3255d69921a58be716 151 Gene3D G3DSA:2.60.120.10 7 142 4.4E-16 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS43445 ecd07df58ad1ad3255d69921a58be716 151 SUPERFAMILY SSF51206 7 142 3.67E-19 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS43445 ecd07df58ad1ad3255d69921a58be716 151 Pfam PF00027 Cyclic nucleotide-binding domain 26 112 1.2E-11 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS08555 55c6c2a202536fc760d30fca42c77742 269 Gene3D G3DSA:3.40.50.300 23 240 1.2E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08555 55c6c2a202536fc760d30fca42c77742 269 SUPERFAMILY SSF52540 23 239 2.3E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08555 55c6c2a202536fc760d30fca42c77742 269 Pfam PF00005 ABC transporter 40 186 2.7E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS08555 55c6c2a202536fc760d30fca42c77742 269 SMART SM00382 49 241 7.4E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 SUPERFAMILY SSF48179 185 283 1.19E-29 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 PIRSF PIRSF000105 2 285 2.5E-80 T 17-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 Gene3D G3DSA:3.40.50.720 8 187 4.1E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 8 183 4.2E-48 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 186 282 4.9E-29 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 SUPERFAMILY SSF51735 8 185 1.9E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16760 968a5cced80ff509fb3418402397acd3 287 Gene3D G3DSA:1.10.1040.10 188 282 1.5E-29 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 13 606 5.1E-101 T 17-03-2017 IPR005674 CocE/Serine esterase GO:0016787 SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 Gene3D G3DSA:3.40.50.1820 228 368 3.5E-71 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 Gene3D G3DSA:3.40.50.1820 6 153 3.5E-71 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 SUPERFAMILY SSF49785 374 605 2.55E-52 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 17 297 3.9E-55 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 343 603 4.2E-49 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 SUPERFAMILY SSF53474 4 376 2.37E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 SMART SM00939 328 604 6.0E-75 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS07900 13846a81c598a9cd65c970415905f270 610 Gene3D G3DSA:2.60.120.260 369 605 2.3E-79 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 SUPERFAMILY SSF49503 78 220 7.74E-37 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 Pfam PF00394 Multicopper oxidase 298 398 3.2E-20 T 17-03-2017 IPR001117 Multicopper oxidase, type 1 GO:0016491|GO:0055114 SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 ProSitePatterns PS00080 Multicopper oxidases signature 2. 528 539 - T 17-03-2017 IPR002355 Multicopper oxidase, copper-binding site GO:0005507 SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 SUPERFAMILY SSF49503 285 408 1.99E-31 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 SUPERFAMILY SSF49503 203 229 1.99E-31 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 SUPERFAMILY SSF49503 432 542 1.11E-32 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 Gene3D G3DSA:2.60.40.420 205 423 5.1E-44 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 Gene3D G3DSA:2.60.40.420 75 203 1.6E-33 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 Pfam PF07731 Multicopper oxidase 438 541 2.2E-23 T 17-03-2017 IPR011706 Multicopper oxidase, type 2 GO:0005507|GO:0016491|GO:0055114 SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 Gene3D G3DSA:2.60.40.420 424 546 5.8E-42 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS19355 62a79ddea1b3c7833fa65b6f9b88a57d 547 Pfam PF07732 Multicopper oxidase 99 201 8.0E-33 T 17-03-2017 IPR011707 Multicopper oxidase, type 3 GO:0005507 SHXM_RS13445 d546268d7a6031a2c4d08341b82a74fc 307 SUPERFAMILY SSF160240 217 295 2.75E-11 T 17-03-2017 SHXM_RS13445 d546268d7a6031a2c4d08341b82a74fc 307 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 21 296 2.5E-88 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS13445 d546268d7a6031a2c4d08341b82a74fc 307 Gene3D G3DSA:1.20.1510.10 19 213 1.4E-56 T 17-03-2017 IPR027469 Cation efflux protein transmembrane domain SHXM_RS13445 d546268d7a6031a2c4d08341b82a74fc 307 SUPERFAMILY SSF161111 18 214 1.83E-52 T 17-03-2017 SHXM_RS13445 d546268d7a6031a2c4d08341b82a74fc 307 Pfam PF01545 Cation efflux family 22 213 4.9E-45 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS34895 ebfda543c231980da2adbff43f86f574 282 ProSitePatterns PS00953 Glycosyl hydrolases family 25 active sites signature. 81 114 - T 17-03-2017 IPR008270 Glycoside hydrolase, family 25, active site GO:0003796|GO:0009253|GO:0016998 SHXM_RS34895 ebfda543c231980da2adbff43f86f574 282 Gene3D G3DSA:3.20.20.80 76 281 1.2E-71 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS34895 ebfda543c231980da2adbff43f86f574 282 SUPERFAMILY SSF51445 77 281 4.21E-65 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS34895 ebfda543c231980da2adbff43f86f574 282 SMART SM00641 77 186 2.3E-48 T 17-03-2017 IPR018077 Glycoside hydrolase, family 25 subgroup SHXM_RS34895 ebfda543c231980da2adbff43f86f574 282 Pfam PF01183 Glycosyl hydrolases family 25 80 264 1.9E-52 T 17-03-2017 IPR002053 Glycoside hydrolase, family 25 GO:0003796|GO:0009253|GO:0016998 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Pfam PF16657 Maltogenic Amylase, C-terminal domain 481 564 8.4E-23 T 17-03-2017 IPR032091 Maltogenic Amylase, C-terminal SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Pfam PF00128 Alpha amylase, catalytic domain 46 402 1.7E-76 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 SUPERFAMILY SSF51445 371 478 1.04E-134 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 SUPERFAMILY SSF51445 20 344 1.04E-134 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Gene3D G3DSA:3.20.20.80 198 427 4.0E-112 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Gene3D G3DSA:3.20.20.80 460 474 4.0E-112 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Gene3D G3DSA:3.20.20.80 25 122 4.0E-112 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 SUPERFAMILY SSF51011 486 567 6.48E-16 T 17-03-2017 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 TIGRFAM TIGR02456 treS_nterm: trehalose synthase 23 567 6.5E-301 T 17-03-2017 IPR012810 Trehalose synthase/alpha-amylase, N-terminal GO:0003824|GO:0005975 KEGG: 00500+5.4.99.16|MetaCyc: PWY-2622 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 SMART SM00642 31 433 1.7E-121 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Gene3D G3DSA:3.90.400.10 123 190 4.2E-24 T 17-03-2017 SHXM_RS35705 1fb7ec58f5e4b3915e3595a4c0d1afe0 578 Gene3D G3DSA:2.60.40.1180 486 566 1.8E-10 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 32 42 6.0E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 53 6.0E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 21 32 6.0E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 SUPERFAMILY SSF53850 96 281 3.48E-18 T 17-03-2017 SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 65 5.1E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 SUPERFAMILY SSF46785 5 88 6.52E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 Pfam PF03466 LysR substrate binding domain 95 284 3.2E-18 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 Gene3D G3DSA:1.10.10.10 4 83 6.2E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14040 3540ca9fd9761abe9ad06c279fee4126 287 Gene3D G3DSA:3.40.190.10 99 194 2.5E-13 T 17-03-2017 SHXM_RS20910 7846124455d9f37900439768f4396baa 399 Pfam PF07730 Histidine kinase 188 251 1.2E-12 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS20910 7846124455d9f37900439768f4396baa 399 Gene3D G3DSA:3.30.565.10 304 385 3.9E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20910 7846124455d9f37900439768f4396baa 399 SUPERFAMILY SSF55874 277 385 7.74E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM00823 Phosphopantetheine attachment site 2600 2672 2.9E-4 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF08659 KR domain 2319 2497 1.1E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF51735 2317 2558 3.56E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.50.150 1496 1675 5.5E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.90.180.10 1931 2068 2.3E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:1.10.1200.10 2599 2669 2.6E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF53335 1497 1688 2.94E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF53901 4 373 4.81E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF53901 410 430 4.81E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM00829 1933 2281 1.6E-133 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF51735 1702 1906 1.83E-14 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.30.70.250 776 833 4.2E-6 T 17-03-2017 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.50.720 2321 2498 3.4E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 654 971 1.3E-100 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.50.720 2069 2177 1.1E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM01294 2601 2668 4.1E-4 T 17-03-2017 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF47336 2598 2675 1.31E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM00825 Beta-ketoacyl synthase 9 435 1.2E-177 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF50129 1926 2075 5.5E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF55048 777 840 1.83E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 265 380 3.4E-32 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2319 2499 3.4E-44 T 17-03-2017 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.366.10 841 938 2.1E-69 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.366.10 645 773 2.1E-69 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.47.10 2 269 2.2E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF08242 Methyltransferase domain 1523 1623 3.2E-14 T 17-03-2017 IPR013217 Methyltransferase type 12 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF51735 2037 2194 3.84E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF52151 650 779 2.17E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SUPERFAMILY SSF52151 843 942 2.17E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 7 256 6.9E-82 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF00550 Phosphopantetheine attachment site 2601 2666 2.5E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF00107 Zinc-binding dehydrogenase 2077 2178 2.2E-22 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 383 497 3.4E-17 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1950 2014 1.3E-4 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF00698 Acyl transferase domain 653 932 1.8E-69 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 SMART SM00826 1035 1194 5.0E-26 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Gene3D G3DSA:3.40.47.10 270 435 1.3E-51 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 Pfam PF14765 Polyketide synthase dehydratase 1035 1303 5.9E-52 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS11075 42620aaaf2c108a67cb22225d649822c 2723 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 169 185 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SMART SM00732 325 424 1.5E-38 T 17-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SUPERFAMILY SSF158832 3 320 4.84E-114 T 17-03-2017 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SUPERFAMILY SSF47781 560 631 3.56E-19 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Pfam PF09371 Tex-like protein N-terminal domain 9 192 1.1E-66 T 17-03-2017 IPR018974 Tex-like protein, N-terminal SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SMART SM00316 649 720 1.1E-24 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Pfam PF16921 Tex protein YqgF-like domain 326 451 7.8E-51 T 17-03-2017 IPR032639 Tex protein, YqgF-like domain SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Gene3D G3DSA:2.40.50.140 635 720 4.7E-26 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SUPERFAMILY SSF47781 470 558 1.56E-26 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SUPERFAMILY SSF53098 321 469 7.59E-52 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 SUPERFAMILY SSF50249 638 723 2.16E-23 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Pfam PF00575 S1 RNA binding domain 650 720 4.0E-18 T 17-03-2017 IPR003029 S1 domain GO:0003676 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Pfam PF12836 Helix-hairpin-helix motif 491 555 4.2E-27 T 17-03-2017 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Gene3D G3DSA:3.30.420.140 325 450 2.1E-50 T 17-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Gene3D G3DSA:1.10.3500.10 110 321 1.2E-101 T 17-03-2017 IPR023323 Tex-like domain SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Gene3D G3DSA:1.10.3500.10 451 498 1.2E-101 T 17-03-2017 IPR023323 Tex-like domain SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Gene3D G3DSA:1.10.10.650 3 109 1.2E-43 T 17-03-2017 IPR023319 Tex-like protein, HTH domain SHXM_RS13470 609c7926c1e874518265adf64c5e43b5 803 Gene3D G3DSA:1.10.150.310 499 630 8.4E-45 T 17-03-2017 IPR023097 Tex RuvX-like domain SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 SUPERFAMILY SSF50715 4 187 2.62E-45 T 17-03-2017 IPR011035 Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain GO:0006412 Reactome: R-HSA-2408517|Reactome: R-HSA-379716 SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 ProDom PD012503 RIBOSOMAL L25 50S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN STRESS GENERAL CTC RRNA 4 95 2.0E-28 T 17-03-2017 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 Gene3D G3DSA:2.40.240.10 4 94 1.3E-25 T 17-03-2017 IPR020056 Ribosomal protein L25/Gln-tRNA synthetase, beta-barrel domain Reactome: R-HSA-2408517|Reactome: R-HSA-379716 SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 Pfam PF14693 Ribosomal protein TL5, C-terminal domain 100 180 5.0E-19 T 17-03-2017 IPR020057 Ribosomal protein L25, beta domain SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 TIGRFAM TIGR00731 bL25_bact_ctc: ribosomal protein bL25, Ctc-form 7 178 2.2E-38 T 17-03-2017 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 Pfam PF01386 Ribosomal L25p family 6 92 1.1E-22 T 17-03-2017 IPR029751 Ribosomal protein L25 GO:0003735|GO:0005840|GO:0006412|GO:0008097 SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 Gene3D G3DSA:2.170.120.20 97 187 1.7E-21 T 17-03-2017 IPR020057 Ribosomal protein L25, beta domain SHXM_RS32795 62aedaa8a4e44c5f3a600af39b257012 199 Hamap MF_01334 50S ribosomal protein L25 [rplY]. 4 181 26.159 T 17-03-2017 IPR001021 Ribosomal protein L25, long-form GO:0003735|GO:0005840|GO:0006412|GO:0008097 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 SUPERFAMILY SSF54919 3 135 6.55E-52 T 17-03-2017 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 ProSitePatterns PS00469 Nucleoside diphosphate kinases active site. 114 122 - T 17-03-2017 IPR023005 Nucleoside diphosphate kinase, active site KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 SMART SM00562 2 136 1.8E-71 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 114 133 5.5E-41 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 5 27 5.5E-41 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 50 69 5.5E-41 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 91 107 5.5E-41 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 PRINTS PR01243 Nucleoside diphosphate kinase signature 70 87 5.5E-41 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 Gene3D G3DSA:3.30.70.141 3 134 2.3E-54 T 17-03-2017 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 Pfam PF00334 Nucleoside diphosphate kinase 3 134 6.5E-51 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS21655 f85faf180e6dce72df2fa7c37e224ca6 137 Hamap MF_00451 Nucleoside diphosphate kinase [ndk]. 2 136 32.173 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 PRINTS PR00923 Lactococcus X-Pro dipeptidyl-peptidase (S15) family signature 56 66 5.9E-6 T 17-03-2017 IPR008252 Peptidase S15, X-Pro dipeptidyl-peptidase GO:0004177|GO:0006508 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 PRINTS PR00923 Lactococcus X-Pro dipeptidyl-peptidase (S15) family signature 74 83 5.9E-6 T 17-03-2017 IPR008252 Peptidase S15, X-Pro dipeptidyl-peptidase GO:0004177|GO:0006508 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 PRINTS PR00923 Lactococcus X-Pro dipeptidyl-peptidase (S15) family signature 91 107 5.9E-6 T 17-03-2017 IPR008252 Peptidase S15, X-Pro dipeptidyl-peptidase GO:0004177|GO:0006508 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 PRINTS PR00923 Lactococcus X-Pro dipeptidyl-peptidase (S15) family signature 584 599 5.9E-6 T 17-03-2017 IPR008252 Peptidase S15, X-Pro dipeptidyl-peptidase GO:0004177|GO:0006508 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 SUPERFAMILY SSF53474 40 396 7.11E-65 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 SUPERFAMILY SSF49785 434 620 4.76E-30 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 Gene3D G3DSA:2.60.120.260 409 621 1.9E-27 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 70 344 1.9E-58 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 373 598 2.9E-32 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 Gene3D G3DSA:3.40.50.1820 55 225 7.6E-87 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 Gene3D G3DSA:3.40.50.1820 291 408 7.6E-87 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 SMART SM00939 361 617 1.5E-41 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS06480 3054755c7388cdb878f8e686cff31453 632 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 75 418 7.6E-32 T 17-03-2017 IPR005674 CocE/Serine esterase GO:0016787 SHXM_RS40355 e96dd6c8fca0bb1fdc7f932f948c6b1b 319 SUPERFAMILY SSF53474 26 224 4.73E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40355 e96dd6c8fca0bb1fdc7f932f948c6b1b 319 Gene3D G3DSA:3.40.50.1820 22 257 3.9E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40355 e96dd6c8fca0bb1fdc7f932f948c6b1b 319 Pfam PF12740 Chlorophyllase enzyme 36 154 3.4E-7 T 17-03-2017 IPR017395 Chlorophyllase GO:0015996|GO:0047746 KEGG: 00860+3.1.1.14|MetaCyc: PWY-5098|MetaCyc: PWY-6927|MetaCyc: PWY-7164 SHXM_RS47695 eb5f7c3c5138dbbd2f86c8202859514a 404 Pfam PF07690 Major Facilitator Superfamily 19 345 1.4E-31 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS47695 eb5f7c3c5138dbbd2f86c8202859514a 404 Gene3D G3DSA:1.20.1250.20 212 388 2.4E-14 T 17-03-2017 SHXM_RS47695 eb5f7c3c5138dbbd2f86c8202859514a 404 Gene3D G3DSA:1.20.1250.20 15 197 1.0E-21 T 17-03-2017 SHXM_RS47695 eb5f7c3c5138dbbd2f86c8202859514a 404 SUPERFAMILY SSF103473 6 389 2.75E-52 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS07455 8360e3c4c5ce82b6ec229e777336d538 492 Gene3D G3DSA:3.40.50.720 138 240 2.4E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07455 8360e3c4c5ce82b6ec229e777336d538 492 Gene3D G3DSA:3.40.50.720 332 470 2.4E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07455 8360e3c4c5ce82b6ec229e777336d538 492 Pfam PF00106 short chain dehydrogenase 156 244 9.3E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07455 8360e3c4c5ce82b6ec229e777336d538 492 SUPERFAMILY SSF51735 337 438 2.74E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07455 8360e3c4c5ce82b6ec229e777336d538 492 SUPERFAMILY SSF51735 150 248 2.74E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07620 d682e16ea6e3affe81c5f36114d75eac 492 SUPERFAMILY SSF56601 30 347 5.46E-80 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS07620 d682e16ea6e3affe81c5f36114d75eac 492 Pfam PF00144 Beta-lactamase 32 340 1.6E-67 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS07620 d682e16ea6e3affe81c5f36114d75eac 492 Gene3D G3DSA:3.40.710.10 18 344 7.7E-78 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 Pfam PF00175 Oxidoreductase NAD-binding domain 115 205 2.1E-4 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 SUPERFAMILY SSF63380 11 103 2.87E-26 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 SUPERFAMILY SSF52343 101 224 1.57E-24 T 17-03-2017 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 SUPERFAMILY SSF54292 211 321 3.54E-25 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 271 279 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 55 69 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 139 148 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 79 93 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 114 133 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 33 43 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 43 55 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 PRINTS PR00409 Phthalate dioxygenase reductase family signature 191 199 1.8E-25 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 Gene3D G3DSA:3.10.20.30 217 320 4.0E-27 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 244 312 3.6E-11 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 Pfam PF00970 Oxidoreductase FAD-binding domain 13 105 7.3E-6 T 17-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 Gene3D G3DSA:3.40.50.80 109 216 1.1E-21 T 17-03-2017 SHXM_RS32290 5756f2cd91ab3e93dc99ac529a04d80d 322 Gene3D G3DSA:2.40.30.10 10 104 1.9E-31 T 17-03-2017 SHXM_RS00150 bdf770bde321789e1ac6190885565567 144 Gene3D G3DSA:1.10.10.60 2 65 2.6E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00150 bdf770bde321789e1ac6190885565567 144 Pfam PF13592 Winged helix-turn helix 77 135 1.7E-17 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS00150 bdf770bde321789e1ac6190885565567 144 SUPERFAMILY SSF46689 2 107 6.0E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00150 bdf770bde321789e1ac6190885565567 144 Pfam PF13551 Winged helix-turn helix 2 58 2.4E-14 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 Gene3D G3DSA:3.50.50.60 14 112 2.9E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 15 321 2.5E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 Gene3D G3DSA:3.50.50.60 242 334 4.1E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 Gene3D G3DSA:3.30.390.30 343 414 1.1E-18 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 Pfam PF14759 Reductase C-terminal 343 414 1.3E-9 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 109 127 2.2E-10 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 156 174 2.2E-10 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 243 259 2.2E-10 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 16 35 2.2E-10 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 SUPERFAMILY SSF55424 336 415 3.98E-19 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 244 258 6.7E-11 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 15 37 6.7E-11 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 290 297 6.7E-11 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 156 181 6.7E-11 T 17-03-2017 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 Gene3D G3DSA:3.50.50.60 113 241 1.0E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 SUPERFAMILY SSF51905 15 194 1.36E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30560 2e8344486fc84111dfd5b836143f505c 468 SUPERFAMILY SSF51905 154 332 1.13E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS17110 074f323576a39b5815a0845715baac05 549 Pfam PF13556 PucR C-terminal helix-turn-helix domain 486 544 9.0E-19 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS17110 074f323576a39b5815a0845715baac05 549 Pfam PF07905 Purine catabolism regulatory protein-like family 12 132 2.5E-37 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS17110 074f323576a39b5815a0845715baac05 549 Gene3D G3DSA:1.10.10.60 490 522 1.5E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22910 1aaa9854274ca4bde870ba5febd2cef8 791 TIGRFAM TIGR03882 cyclo_dehyd_2: bacteriocin biosynthesis cyclodehydratase domain 220 384 1.8E-37 T 17-03-2017 IPR022291 Bacteriocin biosynthesis, cyclodehydratase domain SHXM_RS22910 1aaa9854274ca4bde870ba5febd2cef8 791 TIGRFAM TIGR03604 TOMM_cyclo_SagD: thiazole/oxazole-forming peptide maturase, SagD family component 429 789 1.1E-69 T 17-03-2017 IPR027624 Thiazole/oxazole-forming peptide maturase, SagD family component SHXM_RS22910 1aaa9854274ca4bde870ba5febd2cef8 791 Gene3D G3DSA:3.40.50.720 198 335 1.4E-4 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22910 1aaa9854274ca4bde870ba5febd2cef8 791 Pfam PF02624 YcaO cyclodehydratase, ATP-ad Mg2+-binding 429 754 5.1E-88 T 17-03-2017 IPR003776 YcaO-like domain SHXM_RS22910 1aaa9854274ca4bde870ba5febd2cef8 791 TIGRFAM TIGR00702 TIGR00702: YcaO-type kinase domain 425 659 1.3E-22 T 17-03-2017 IPR003776 YcaO-like domain SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 SUPERFAMILY SSF53850 102 267 9.62E-25 T 17-03-2017 SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 Gene3D G3DSA:3.40.190.10 196 237 2.0E-5 T 17-03-2017 SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 Pfam PF03466 LysR substrate binding domain 195 266 4.5E-8 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 Pfam PF03466 LysR substrate binding domain 101 190 5.4E-15 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 2.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 2.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 2.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 Gene3D G3DSA:1.10.10.10 2 84 5.5E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 Gene3D G3DSA:3.40.190.10 104 184 4.3E-14 T 17-03-2017 SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 SUPERFAMILY SSF46785 3 89 1.17E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42210 afc46207ad0efa641cadb86cf9324523 269 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 64 3.6E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 Pfam PF01281 Ribosomal protein L9, N-terminal domain 1 45 2.2E-21 T 17-03-2017 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 Pfam PF03948 Ribosomal protein L9, C-terminal domain 63 147 3.6E-29 T 17-03-2017 IPR020069 Ribosomal protein L9, C-terminal SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 SUPERFAMILY SSF55658 1 56 2.09E-17 T 17-03-2017 IPR009027 Ribosomal protein L9/RNase H1, N-terminal SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 SUPERFAMILY SSF55653 58 147 1.7E-25 T 17-03-2017 IPR020069 Ribosomal protein L9, C-terminal SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 Hamap MF_00503 50S ribosomal protein L9 [rplI]. 1 148 26.261 T 17-03-2017 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 Gene3D G3DSA:3.10.430.100 62 147 8.0E-31 T 17-03-2017 IPR020069 Ribosomal protein L9, C-terminal SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 Gene3D G3DSA:3.40.5.10 1 51 1.5E-22 T 17-03-2017 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 TIGRFAM TIGR00158 L9: ribosomal protein bL9 1 147 1.7E-40 T 17-03-2017 IPR020594 Ribosomal protein L9, bacteria/chloroplast GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS27975 d218da5cb14d96f15ec73f3414b49d5f 148 ProSitePatterns PS00651 Ribosomal protein L9 signature. 13 40 - T 17-03-2017 IPR020070 Ribosomal protein L9, N-terminal Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3 176 2.2E-9 T 17-03-2017 SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 127 155 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 67 78 4.5E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 159 4.5E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 120 128 4.5E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 SUPERFAMILY SSF51735 3 230 3.45E-83 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 Gene3D G3DSA:3.40.50.720 3 230 2.6E-83 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 230 2.6E-63 T 17-03-2017 SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 178 3.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 3.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 194 214 3.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 67 78 3.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 140 159 3.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 114 130 3.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17310 43d2231b5163793d5b1c17ba1178f2a6 234 TIGRFAM TIGR01830 3oxo_ACP_reduc: 3-oxoacyl-[acyl-carrier-protein] reductase 5 230 1.3E-94 T 17-03-2017 IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase GO:0004316|GO:0006633|GO:0051287|GO:0055114 KEGG: 00040+1.1.1.10|KEGG: 00061+1.1.1.100|KEGG: 00780+1.1.1.100|MetaCyc: PWY-5367|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 529 545 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 237 252 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 273 288 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 300 316 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 151 166 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 96 115 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 20 37 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PRINTS PR00742 Glycosyl hydrolase family 35 signature 41 59 2.9E-54 T 17-03-2017 IPR001944 Glycoside hydrolase, family 35 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 Gene3D G3DSA:2.60.120.260 451 576 1.0E-29 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 Pfam PF01301 Glycosyl hydrolases family 35 17 331 1.2E-111 T 17-03-2017 IPR031330 Glycoside hydrolase 35, catalytic domain KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 SUPERFAMILY SSF49785 448 574 3.4E-27 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 Gene3D G3DSA:3.20.20.80 8 332 1.0E-117 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 SUPERFAMILY SSF51445 10 332 1.11E-100 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 ProSitePatterns PS01182 Glycosyl hydrolases family 35 putative active site. 153 165 - T 17-03-2017 IPR019801 Glycoside hydrolase, family 35, conserved site GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS48445 4606404236b3054e2a170e94ad6cd6ef 589 PIRSF PIRSF006336 2 588 1.3E-203 T 17-03-2017 IPR026283 Beta-galactosidase 1-like GO:0004565 SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 Gene3D G3DSA:1.10.10.10 12 79 8.1E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 SMART SM00895 100 221 1.1E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 SUPERFAMILY SSF46785 9 80 1.49E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 Pfam PF07729 FCD domain 100 220 4.4E-30 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 SMART SM00345 17 76 1.1E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 Pfam PF00392 Bacterial regulatory proteins, gntR family 21 76 6.5E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 1.5E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 1.5E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 Gene3D G3DSA:1.20.120.530 96 232 3.1E-34 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS32990 596741912485a5c9ef40b9c94dd9efbd 252 SUPERFAMILY SSF48008 97 227 1.88E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS46665 f2b4c869ead578ce7bc61646e7c8a00b 146 Gene3D G3DSA:3.10.450.50 4 131 3.8E-31 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS46665 f2b4c869ead578ce7bc61646e7c8a00b 146 TIGRFAM TIGR02246 TIGR02246: conserved hypothetical protein 8 135 5.0E-34 T 17-03-2017 IPR011944 Steroid delta5-4-isomerase KEGG: 00140+5.3.3.1|KEGG: 00984+5.3.3.1|MetaCyc: PWY-2582|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-6948|MetaCyc: PWY-699|MetaCyc: PWY-7299 SHXM_RS46665 f2b4c869ead578ce7bc61646e7c8a00b 146 Pfam PF14534 Domain of unknown function (DUF4440) 13 126 6.0E-7 T 17-03-2017 IPR027843 Domain of unknown function DUF4440 SHXM_RS46665 f2b4c869ead578ce7bc61646e7c8a00b 146 SUPERFAMILY SSF54427 5 133 5.27E-23 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS43085 2537ae18cc31f46d0c54f11cc2c19b1c 130 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 114 8.6E-12 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS43085 2537ae18cc31f46d0c54f11cc2c19b1c 130 Gene3D G3DSA:3.10.180.10 10 124 2.1E-26 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS43085 2537ae18cc31f46d0c54f11cc2c19b1c 130 SUPERFAMILY SSF54593 9 121 5.24E-25 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS46980 b7bd8004af293867fa917acd93ae70cf 350 Gene3D G3DSA:3.40.1190.20 17 313 1.5E-54 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS46980 b7bd8004af293867fa917acd93ae70cf 350 Pfam PF00294 pfkB family carbohydrate kinase 18 300 1.8E-30 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS46980 b7bd8004af293867fa917acd93ae70cf 350 SUPERFAMILY SSF53613 17 311 3.74E-48 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 SUPERFAMILY SSF52402 112 249 7.03E-23 T 17-03-2017 SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 Gene3D G3DSA:3.40.50.620 106 240 4.3E-27 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 Gene3D G3DSA:3.40.50.620 241 391 2.0E-20 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 PRINTS PR01438 Universal stress protein signature 111 129 2.6E-9 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 PRINTS PR01438 Universal stress protein signature 223 245 2.6E-9 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 PRINTS PR01438 Universal stress protein signature 205 217 2.6E-9 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 Pfam PF00582 Universal stress protein family 110 245 2.4E-20 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 Pfam PF00582 Universal stress protein family 256 391 2.5E-10 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS08000 ec52510aeb8473620517f7fd754bd75d 393 SUPERFAMILY SSF52402 255 391 1.67E-16 T 17-03-2017 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Pfam PF03308 ArgK protein 164 362 2.9E-38 T 17-03-2017 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 SUPERFAMILY SSF52540 124 440 2.15E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Pfam PF02310 B12 binding domain 12 108 1.2E-11 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 707 1075 1.4E-94 T 17-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Gene3D G3DSA:3.40.50.300 193 394 4.8E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Gene3D G3DSA:3.40.50.280 6 137 3.4E-34 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Gene3D G3DSA:3.20.20.240 545 1072 6.2E-193 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 SUPERFAMILY SSF52242 6 142 3.14E-39 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 SUPERFAMILY SSF51703 501 1072 1.36E-150 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Hamap MF_02050 Fused isobutyryl-CoA mutase [icmF]. 10 1076 16.754 T 17-03-2017 IPR033669 Fused isobutyryl-CoA mutase GO:0003924|GO:0005525|GO:0006637|GO:0031419|GO:0034784|GO:0047727 SHXM_RS40945 2534c54efbb27042e781e82d63350267 1076 Pfam PF01642 Methylmalonyl-CoA mutase 553 1070 1.7E-144 T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 Pfam PF07568 Histidine kinase 290 360 2.2E-22 T 17-03-2017 IPR011495 Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 Gene3D G3DSA:3.30.450.20 173 281 5.1E-5 T 17-03-2017 SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 Pfam PF08448 PAS fold 172 276 5.4E-13 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 SUPERFAMILY SSF55874 365 484 4.19E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 Gene3D G3DSA:3.30.565.10 345 487 9.3E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 SUPERFAMILY SSF55785 173 281 2.62E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 Pfam PF12282 Signal transduction histidine kinase 1 144 7.0E-60 T 17-03-2017 IPR022066 Signal transduction histidine kinase SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 385 484 5.7E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34610 54d44c6a421a74ee8bfad2ba0c3dca83 489 SMART SM00387 382 486 9.3E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08515 7ab662c2f2841e11a9b4457e67e8b759 142 SUPERFAMILY SSF55874 41 137 6.82E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08515 7ab662c2f2841e11a9b4457e67e8b759 142 Gene3D G3DSA:3.30.565.10 40 137 9.6E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08515 7ab662c2f2841e11a9b4457e67e8b759 142 Pfam PF13581 Histidine kinase-like ATPase domain 12 133 4.4E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 Gene3D G3DSA:3.40.50.1000 3 221 1.0E-41 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 96 210 1.0E-8 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 3 14 6.2E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 173 193 6.2E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 125 138 6.2E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 155 171 6.2E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 200 213 6.2E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 117 202 1.8E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 Pfam PF13419 Haloacid dehalogenase-like hydrolase 97 209 1.2E-12 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42785 cc109e6be95ff25e5319d5d120ae0c3a 237 SUPERFAMILY SSF56784 4 214 8.42E-38 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS26945 09d46ae05c263fc7744fbeaf8f8e5291 334 SUPERFAMILY SSF52540 89 244 1.28E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26945 09d46ae05c263fc7744fbeaf8f8e5291 334 SUPERFAMILY SSF52540 1 51 1.28E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26945 09d46ae05c263fc7744fbeaf8f8e5291 334 Gene3D G3DSA:3.40.50.300 1 278 2.1E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26945 09d46ae05c263fc7744fbeaf8f8e5291 334 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 6 220 1.1E-9 T 17-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SHXM_RS41760 fed395ab09d316b21688964a5991f2a5 666 SUPERFAMILY SSF82866 36 255 2.62E-33 T 17-03-2017 SHXM_RS41760 fed395ab09d316b21688964a5991f2a5 666 Gene3D G3DSA:1.20.1640.10 57 256 2.9E-32 T 17-03-2017 SHXM_RS41760 fed395ab09d316b21688964a5991f2a5 666 Gene3D G3DSA:1.20.1640.10 416 626 3.8E-31 T 17-03-2017 SHXM_RS41760 fed395ab09d316b21688964a5991f2a5 666 Pfam PF03176 MMPL family 318 628 4.3E-35 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS41760 fed395ab09d316b21688964a5991f2a5 666 Pfam PF03176 MMPL family 32 288 2.9E-44 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS41760 fed395ab09d316b21688964a5991f2a5 666 SUPERFAMILY SSF82866 412 625 2.35E-27 T 17-03-2017 SHXM_RS22335 62cfc8e3824502158c7f24990a237e8f 647 Gene3D G3DSA:3.40.50.2300 377 489 1.5E-38 T 17-03-2017 SHXM_RS22335 62cfc8e3824502158c7f24990a237e8f 647 Pfam PF13407 Periplasmic binding protein domain 379 632 3.2E-66 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS22335 62cfc8e3824502158c7f24990a237e8f 647 Gene3D G3DSA:3.40.50.2300 490 646 2.0E-53 T 17-03-2017 SHXM_RS22335 62cfc8e3824502158c7f24990a237e8f 647 SUPERFAMILY SSF53822 358 646 7.35E-87 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS22335 62cfc8e3824502158c7f24990a237e8f 647 Pfam PF02653 Branched-chain amino acid transport system / permease component 49 312 3.3E-45 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS36110 a26651227074dfcf402aa8ff1511ee52 496 Pfam PF07171 MlrC C-terminus 303 473 7.8E-48 T 17-03-2017 IPR010799 Microcystin LR degradation protein MlrC, C-terminal SHXM_RS36110 a26651227074dfcf402aa8ff1511ee52 496 Pfam PF07364 Metallopeptidase family M81 12 293 5.2E-104 T 17-03-2017 IPR015995 Microcystin LR degradation protein MlrC, N-terminal SHXM_RS36110 a26651227074dfcf402aa8ff1511ee52 496 PIRSF PIRSF012702 8 491 5.8E-140 T 17-03-2017 IPR009197 Microcystin LR degradation protein MlrC SHXM_RS15875 38c15711d43ed2120572b88530487f22 319 PIRSF PIRSF016838 2 319 1.4E-81 T 17-03-2017 IPR028349 Protein PafC SHXM_RS15875 38c15711d43ed2120572b88530487f22 319 Pfam PF13280 WYL domain 144 314 8.5E-30 T 17-03-2017 IPR026881 WYL domain SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 SUPERFAMILY SSF88659 194 256 4.11E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 SUPERFAMILY SSF88946 84 174 4.32E-23 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 Gene3D G3DSA:1.10.1740.10 82 161 1.3E-27 T 17-03-2017 SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 94 254 2.7E-25 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 Pfam PF04542 Sigma-70 region 2 95 159 3.5E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 Pfam PF08281 Sigma-70, region 4 201 251 2.0E-13 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 Gene3D G3DSA:1.10.10.10 194 258 6.3E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34460 59050e9a27b699f60e07494257b77a2d 284 TIGRFAM TIGR02947 SigH_actino: RNA polymerase sigma-70 factor, TIGR02947 family 79 266 2.2E-107 T 17-03-2017 IPR014293 RNA polymerase sigma-70, actinobacteria GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 Gene3D G3DSA:1.10.10.10 8 93 4.8E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 Gene3D G3DSA:3.40.190.10 95 193 6.3E-13 T 17-03-2017 SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 SUPERFAMILY SSF46785 7 118 4.95E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 Gene3D G3DSA:3.40.190.10 194 271 7.3E-15 T 17-03-2017 SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 10 69 2.6E-13 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 SUPERFAMILY SSF53850 96 298 1.38E-24 T 17-03-2017 SHXM_RS48085 c354544654dab421dbcbae9c83d26c09 317 Pfam PF03466 LysR substrate binding domain 94 301 2.3E-24 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 SUPERFAMILY SSF53067 470 558 1.94E-5 T 17-03-2017 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 SUPERFAMILY SSF53067 628 734 1.94E-5 T 17-03-2017 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 SUPERFAMILY SSF54975 1 77 1.16E-16 T 17-03-2017 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 Pfam PF00708 Acylphosphatase 1 76 3.0E-15 T 17-03-2017 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 Gene3D G3DSA:3.90.870.10 184 365 3.8E-40 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 TIGRFAM TIGR00143 hypF: carbamoyltransferase HypF 1 733 8.2E-218 T 17-03-2017 IPR004421 Carbamoyltransferase, HypF-type GO:0016743|GO:0046872|GO:0046944 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 Pfam PF01300 Telomere recombination 194 373 2.2E-48 T 17-03-2017 IPR006070 YrdC-like domain GO:0003725 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 Gene3D G3DSA:3.30.70.100 1 76 1.5E-17 T 17-03-2017 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 SUPERFAMILY SSF55821 161 379 4.58E-43 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 PIRSF PIRSF006256 1 739 1.7E-267 T 17-03-2017 IPR004421 Carbamoyltransferase, HypF-type GO:0016743|GO:0046872|GO:0046944 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 Pfam PF07503 HypF finger 144 176 1.9E-17 T 17-03-2017 IPR011125 Zinc finger, HypF-type GO:0008270 SHXM_RS43470 5da80c25a87b931f235274b9d0fbeaee 739 Pfam PF07503 HypF finger 94 126 3.1E-15 T 17-03-2017 IPR011125 Zinc finger, HypF-type GO:0008270 SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 Gene3D G3DSA:3.90.180.10 10 152 6.8E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 SMART SM00829 14 307 3.4E-24 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 Gene3D G3DSA:3.40.50.720 153 247 2.4E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 SUPERFAMILY SSF50129 3 152 1.1E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 31 100 3.4E-11 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 Pfam PF13602 Zinc-binding dehydrogenase 189 307 9.8E-18 T 17-03-2017 SHXM_RS45720 be5ed05d81017912c21b43d5e7f03a00 314 SUPERFAMILY SSF51735 120 246 3.59E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12620 4690da676eb82cf982179ef941051076 241 Pfam PF00929 Exonuclease 11 179 2.4E-16 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS12620 4690da676eb82cf982179ef941051076 241 SUPERFAMILY SSF53098 4 203 9.11E-42 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS12620 4690da676eb82cf982179ef941051076 241 Gene3D G3DSA:3.30.420.10 4 188 4.3E-37 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS12620 4690da676eb82cf982179ef941051076 241 SMART SM00479 8 189 5.5E-22 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SUPERFAMILY SSF54980 640 731 1.53E-19 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Pfam PF14492 Elongation Factor G, domain II 443 514 7.8E-24 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Pfam PF00679 Elongation factor G C-terminus 640 726 8.2E-20 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Pfam PF03144 Elongation factor Tu domain 2 353 429 6.9E-10 T 17-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Gene3D G3DSA:3.30.70.240 642 728 1.6E-20 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Gene3D G3DSA:3.30.70.870 444 515 6.5E-24 T 17-03-2017 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 PRINTS PR00315 GTP-binding elongation factor signature 26 39 9.8E-6 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 PRINTS PR00315 GTP-binding elongation factor signature 92 102 9.8E-6 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 PRINTS PR00315 GTP-binding elongation factor signature 108 119 9.8E-6 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Gene3D G3DSA:3.30.230.10 523 641 1.3E-47 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SUPERFAMILY SSF52540 21 310 1.18E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Gene3D G3DSA:2.40.30.10 333 443 8.0E-28 T 17-03-2017 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Pfam PF03764 Elongation factor G, domain IV 519 636 1.3E-39 T 17-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SUPERFAMILY SSF54211 520 636 1.37E-35 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Gene3D G3DSA:3.40.50.300 19 316 1.6E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SUPERFAMILY SSF54980 443 520 1.01E-17 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SUPERFAMILY SSF50447 327 440 3.03E-23 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SMART SM00889 519 637 1.6E-58 T 17-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 Pfam PF00009 Elongation factor Tu GTP binding domain 24 274 1.5E-27 T 17-03-2017 SHXM_RS12590 e52272db86a68631fcadec28deed8cbe 735 SMART SM00838 639 727 3.4E-16 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 SMART SM00458 669 798 1.9E-26 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 SUPERFAMILY SSF51445 49 349 2.37E-34 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 Gene3D G3DSA:2.60.120.200 537 638 2.4E-4 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 Pfam PF00652 Ricin-type beta-trefoil lectin domain 670 795 2.1E-24 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 Pfam PF02057 Glycosyl hydrolase family 59 40 662 1.7E-104 T 17-03-2017 IPR001286 Glycoside hydrolase, family 59 GO:0004336|GO:0006683 KEGG: 00600+3.2.1.46|Reactome: R-HSA-1660662 SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 PRINTS PR00850 Glycosyl hydrolase family 59 signature 536 565 1.4E-8 T 17-03-2017 IPR001286 Glycoside hydrolase, family 59 GO:0004336|GO:0006683 KEGG: 00600+3.2.1.46|Reactome: R-HSA-1660662 SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 PRINTS PR00850 Glycosyl hydrolase family 59 signature 110 134 1.4E-8 T 17-03-2017 IPR001286 Glycoside hydrolase, family 59 GO:0004336|GO:0006683 KEGG: 00600+3.2.1.46|Reactome: R-HSA-1660662 SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 PRINTS PR00850 Glycosyl hydrolase family 59 signature 340 364 1.4E-8 T 17-03-2017 IPR001286 Glycoside hydrolase, family 59 GO:0004336|GO:0006683 KEGG: 00600+3.2.1.46|Reactome: R-HSA-1660662 SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 Gene3D G3DSA:2.80.10.50 671 797 1.2E-30 T 17-03-2017 SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 SUPERFAMILY SSF50370 667 797 8.08E-33 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 Gene3D G3DSA:3.20.20.80 51 347 2.8E-19 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS48370 066ec2379649acdb39379c4034b178f9 798 SUPERFAMILY SSF49899 536 646 1.56E-5 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS21030 a99cea5dea8ed089547075fc51ae82b6 290 Gene3D G3DSA:1.10.3470.10 42 260 3.8E-10 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS21030 a99cea5dea8ed089547075fc51ae82b6 290 SUPERFAMILY SSF81345 4 259 5.1E-34 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS21030 a99cea5dea8ed089547075fc51ae82b6 290 Pfam PF00950 ABC 3 transport family 7 261 8.1E-66 T 17-03-2017 IPR001626 ABC transporter, TroCD-like GO:0005887|GO:0042626|GO:0043190|GO:0055085 SHXM_RS49365 4294044577b8e75a6fcf2c8d79106fbe 462 Pfam PF06527 TniQ 7 149 3.0E-7 T 17-03-2017 IPR009492 TniQ SHXM_RS46595 532c5def55867df0e1f8e17a7489a3c5 532 SUPERFAMILY SSF56176 69 264 8.41E-43 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS46595 532c5def55867df0e1f8e17a7489a3c5 532 Gene3D G3DSA:3.30.43.10 80 139 1.8E-7 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS46595 532c5def55867df0e1f8e17a7489a3c5 532 Pfam PF01565 FAD binding domain 82 234 1.9E-24 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS46595 532c5def55867df0e1f8e17a7489a3c5 532 Gene3D G3DSA:3.30.465.10 158 261 5.8E-15 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS46595 532c5def55867df0e1f8e17a7489a3c5 532 Pfam PF08031 Berberine and berberine like 487 530 2.5E-16 T 17-03-2017 IPR012951 Berberine/berberine-like GO:0016491|GO:0050660|GO:0055114 SHXM_RS49745 3f5d70039b67299d2b0c52798443207a 93 Pfam PF13458 Periplasmic binding protein 1 66 2.0E-8 T 17-03-2017 IPR028081 Leucine-binding protein domain SHXM_RS49745 3f5d70039b67299d2b0c52798443207a 93 SUPERFAMILY SSF53822 1 69 6.59E-10 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS49745 3f5d70039b67299d2b0c52798443207a 93 Gene3D G3DSA:3.40.50.2300 2 55 6.8E-7 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3364 3380 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF55048 2303 2367 1.07E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF47336 1544 1655 3.4E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1640 1890 6.8E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3201 3451 6.3E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 6.5E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF51735 1045 1255 1.69E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.47.10 1642 1902 1.1E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.47.10 37 297 8.6E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.30.70.250 2302 2367 8.9E-7 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.30.70.250 743 808 5.9E-7 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.30.70.250 3859 3924 8.9E-7 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF08659 KR domain 4384 4562 6.0E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF08659 KR domain 2824 3001 2.3E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF08659 KR domain 1268 1445 1.5E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF53901 1636 2012 1.61E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3137 3152 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF51735 4381 4612 1.74E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.47.10 3207 3463 3.0E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.47.10 1903 2069 3.6E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.47.10 298 465 1.2E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.47.10 3464 3629 3.9E-68 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM01294 3110 3178 2.1E-5 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM01294 1549 1617 4.6E-4 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM01294 4669 4736 2.0E-5 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00550 Phosphopantetheine attachment site 1552 1617 2.7E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00550 Phosphopantetheine attachment site 3111 3178 7.8E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00550 Phosphopantetheine attachment site 4671 4736 5.7E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00823 Phosphopantetheine attachment site 1549 1621 4.6E-28 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00823 Phosphopantetheine attachment site 4668 4740 1.7E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00823 Phosphopantetheine attachment site 3110 3182 5.2E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF53901 3197 3573 3.07E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.366.10 613 740 6.0E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.366.10 2368 2500 1.1E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.366.10 3725 3856 3.7E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.366.10 809 942 6.0E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.366.10 3925 4058 3.7E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.366.10 2169 2299 1.1E-73 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF47336 4661 4742 3.93E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF51735 4161 4371 7.87E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF52151 2368 2463 2.09E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF52151 2174 2304 2.09E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00698 Acyl transferase domain 616 947 1.8E-54 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00698 Acyl transferase domain 3732 4063 4.3E-54 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF00698 Acyl transferase domain 2175 2505 6.2E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF55048 744 808 9.68E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1576 1591 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3579 3692 5.6E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 468 8.7E-10 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2018 2137 3.4E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:1.10.1200.10 4664 4740 1.7E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:1.10.1200.10 1546 1622 4.8E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.50.720 4384 4565 5.3E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.50.720 2824 3045 9.4E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:3.40.50.720 1268 1449 1.2E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF51735 1263 1519 4.9E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF47336 3103 3214 2.62E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3459 3576 4.2E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 1.7E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1898 2015 1.4E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4384 4563 3.1E-50 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1268 1447 1.3E-53 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2824 3003 3.8E-50 T 17-03-2017 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF51735 2819 3065 5.67E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2177 2486 1.1E-117 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 3734 4044 3.4E-118 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 618 928 3.7E-117 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Pfam PF08990 Erythronolide synthase docking 3 27 4.1E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF55048 3860 3924 1.83E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF52151 809 906 3.14E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF52151 615 745 3.14E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF51735 2600 2810 5.51E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF53901 32 407 1.72E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00825 Beta-ketoacyl synthase 37 463 5.5E-221 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00825 Beta-ketoacyl synthase 3203 3629 1.1E-226 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SMART SM00825 Beta-ketoacyl synthase 1642 2068 2.0E-223 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 Gene3D G3DSA:1.10.1200.10 3108 3206 1.4E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF52151 3925 4021 1.99E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 SUPERFAMILY SSF52151 3731 3861 1.99E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06385 45295e7524bb4658df837f5353a29c38 4821 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1803 1819 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS33615 569d42262cca2e0583623cc38313eb38 786 Pfam PF01522 Polysaccharide deacetylase 156 260 1.7E-29 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS33615 569d42262cca2e0583623cc38313eb38 786 Gene3D G3DSA:3.20.20.370 147 359 3.3E-54 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS33615 569d42262cca2e0583623cc38313eb38 786 Pfam PF13641 Glycosyltransferase like family 2 428 646 4.6E-40 T 17-03-2017 SHXM_RS33615 569d42262cca2e0583623cc38313eb38 786 SUPERFAMILY SSF88713 153 358 5.44E-52 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS33615 569d42262cca2e0583623cc38313eb38 786 SUPERFAMILY SSF53448 422 663 4.38E-62 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS33615 569d42262cca2e0583623cc38313eb38 786 Gene3D G3DSA:3.90.550.10 428 661 8.8E-50 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 Gene3D G3DSA:1.20.140.10 239 402 2.5E-44 T 17-03-2017 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 130 7.6E-14 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 249 399 1.7E-32 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 134 235 9.3E-21 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 Gene3D G3DSA:1.10.540.10 1 132 4.2E-32 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 SUPERFAMILY SSF56645 1 262 8.64E-63 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 SUPERFAMILY SSF47203 247 403 4.99E-40 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS16350 34b9de62c051b5df7781db67fb525914 404 Gene3D G3DSA:2.40.110.10 133 238 2.0E-40 T 17-03-2017 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 ProSitePatterns PS00737 Thiolases signature 2. 351 367 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 SUPERFAMILY SSF53901 283 404 3.29E-43 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 Gene3D G3DSA:3.40.47.10 171 209 8.8E-57 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 Gene3D G3DSA:3.40.47.10 289 404 8.8E-57 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 6 403 1.0E-139 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 Pfam PF00108 Thiolase, N-terminal domain 5 274 2.5E-61 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 Pfam PF02803 Thiolase, C-terminal domain 283 404 5.7E-47 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 Gene3D G3DSA:3.40.47.10 210 288 5.0E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 Gene3D G3DSA:3.40.47.10 4 125 5.0E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 PIRSF PIRSF000429 1 406 4.9E-131 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS24485 dbe422970ba6f4d4571509b5e8932867 406 SUPERFAMILY SSF53901 3 282 1.4E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 SMART SM00345 17 75 2.4E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 SMART SM00866 93 234 3.7E-16 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 SUPERFAMILY SSF46785 13 79 2.69E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 Pfam PF07702 UTRA domain 100 232 8.3E-19 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 SUPERFAMILY SSF64288 63 237 3.14E-30 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 65 2.0E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 35 49 2.0E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 Gene3D G3DSA:1.10.10.10 10 71 5.6E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 Pfam PF00392 Bacterial regulatory proteins, gntR family 25 75 4.9E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS08615 87de09bf4cd5209bc42c224a84fa20aa 248 Gene3D G3DSA:3.40.1410.10 72 237 2.4E-28 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS07245 1f9f9a308ca073f19bb461d86de4a7b1 324 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 138 166 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS07245 1f9f9a308ca073f19bb461d86de4a7b1 324 TIGRFAM TIGR01181 dTDP_gluc_dehyt: dTDP-glucose 4,6-dehydratase 2 321 8.5E-138 T 17-03-2017 IPR005888 dTDP-glucose 4,6-dehydratase GO:0008460|GO:0009225 KEGG: 00521+4.2.1.46|KEGG: 00523+4.2.1.46|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SHXM_RS07245 1f9f9a308ca073f19bb461d86de4a7b1 324 SUPERFAMILY SSF51735 2 321 7.63E-98 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07245 1f9f9a308ca073f19bb461d86de4a7b1 324 Pfam PF16363 GDP-mannose 4,6 dehydratase 5 307 2.4E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07245 1f9f9a308ca073f19bb461d86de4a7b1 324 Gene3D G3DSA:3.90.25.10 184 320 3.0E-53 T 17-03-2017 SHXM_RS07245 1f9f9a308ca073f19bb461d86de4a7b1 324 Gene3D G3DSA:3.40.50.720 2 183 3.9E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01910 03d08fc4c92fa8d3bd20e3df566a7844 458 SUPERFAMILY SSF51679 6 447 2.24E-110 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01910 03d08fc4c92fa8d3bd20e3df566a7844 458 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 16 441 6.3E-128 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS01910 03d08fc4c92fa8d3bd20e3df566a7844 458 Gene3D G3DSA:3.20.20.30 362 447 3.8E-118 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01910 03d08fc4c92fa8d3bd20e3df566a7844 458 Gene3D G3DSA:3.20.20.30 5 307 3.8E-118 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01910 03d08fc4c92fa8d3bd20e3df566a7844 458 Pfam PF00296 Luciferase-like monooxygenase 26 395 5.0E-54 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01910 03d08fc4c92fa8d3bd20e3df566a7844 458 PIRSF PIRSF000337 1 456 2.5E-161 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 448 466 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 431 441 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 471 484 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 PRINTS PR00344 Bacterial sensor protein C-terminal signature 413 427 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 SMART SM00304 216 269 0.0021 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 Pfam PF00672 HAMP domain 197 265 8.4E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 SMART SM00388 270 335 4.7E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 Gene3D G3DSA:3.30.565.10 322 487 2.6E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 380 485 2.4E-21 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 SUPERFAMILY SSF55874 324 487 6.02E-38 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 Gene3D G3DSA:1.10.287.130 262 321 1.1E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 Pfam PF00512 His Kinase A (phospho-acceptor) domain 271 334 9.8E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 SMART SM00387 378 487 3.3E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20530 d6f324cb20fc630bf76d37e99437a011 492 SUPERFAMILY SSF47384 253 334 7.06E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS47350 ac08eb914b34c44abea318e83c138bf5 128 Gene3D G3DSA:1.10.10.10 7 114 8.7E-40 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47350 ac08eb914b34c44abea318e83c138bf5 128 SUPERFAMILY SSF46785 10 115 1.33E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47350 ac08eb914b34c44abea318e83c138bf5 128 Pfam PF01638 HxlR-like helix-turn-helix 22 109 2.5E-27 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 Gene3D G3DSA:3.10.20.30 4 77 7.3E-25 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 41 49 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 Gene3D G3DSA:1.10.150.120 80 167 8.8E-27 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 8 54 1.2E-7 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 Pfam PF01799 [2Fe-2S] binding domain 75 162 1.0E-26 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 SUPERFAMILY SSF54292 2 80 3.8E-22 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS16235 8de264f428d4fe4201da8fb291e9c92d 168 SUPERFAMILY SSF47741 80 167 1.44E-25 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS41940 e7f793527f30313684d061c8c9b1a8a2 325 Pfam PF00248 Aldo/keto reductase family 13 306 1.4E-82 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS41940 e7f793527f30313684d061c8c9b1a8a2 325 SUPERFAMILY SSF51430 7 307 1.28E-102 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS41940 e7f793527f30313684d061c8c9b1a8a2 325 PRINTS PR00069 Aldo-keto reductase signature 42 66 4.6E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS41940 e7f793527f30313684d061c8c9b1a8a2 325 PRINTS PR00069 Aldo-keto reductase signature 241 265 4.6E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS41940 e7f793527f30313684d061c8c9b1a8a2 325 PRINTS PR00069 Aldo-keto reductase signature 108 126 4.6E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS41940 e7f793527f30313684d061c8c9b1a8a2 325 Gene3D G3DSA:3.20.20.100 1 310 7.6E-113 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS39520 f44550d0d17f44cd740363ed4781323c 273 SUPERFAMILY SSF103473 23 212 2.88E-14 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS39520 f44550d0d17f44cd740363ed4781323c 273 Gene3D G3DSA:1.20.1250.20 80 211 2.2E-8 T 17-03-2017 SHXM_RS21900 ac41ffb7376492dc93470bca53b17099 367 Gene3D G3DSA:3.30.70.100 220 305 7.0E-5 T 17-03-2017 SHXM_RS21900 ac41ffb7376492dc93470bca53b17099 367 Gene3D G3DSA:2.30.30.60 165 209 4.0E-10 T 17-03-2017 SHXM_RS21900 ac41ffb7376492dc93470bca53b17099 367 Pfam PF00924 Mechanosensitive ion channel 108 306 2.9E-35 T 17-03-2017 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SHXM_RS21900 ac41ffb7376492dc93470bca53b17099 367 SUPERFAMILY SSF82861 87 148 5.62E-9 T 17-03-2017 IPR011014 Mechanosensitive ion channel MscS, transmembrane-2 GO:0016020 SHXM_RS21900 ac41ffb7376492dc93470bca53b17099 367 SUPERFAMILY SSF82689 214 306 2.75E-9 T 17-03-2017 IPR011066 Mechanosensitive ion channel MscS, C-terminal GO:0016020 SHXM_RS21900 ac41ffb7376492dc93470bca53b17099 367 SUPERFAMILY SSF50182 150 207 1.7E-9 T 17-03-2017 IPR010920 LSM domain SHXM_RS41500 383c04cc4afb1b8e38148e691a7b331d 174 Gene3D G3DSA:3.40.50.300 1 173 1.2E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41500 383c04cc4afb1b8e38148e691a7b331d 174 SUPERFAMILY SSF52540 1 173 2.96E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50180 9be98b3b168bd8fcf2343329ed36c2d4 487 Pfam PF00474 Sodium:solute symporter family 32 422 7.0E-34 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS50180 9be98b3b168bd8fcf2343329ed36c2d4 487 ProSitePatterns PS00457 Sodium:solute symporter family signature 2. 404 424 - T 17-03-2017 IPR018212 Sodium/solute symporter, conserved site GO:0005215|GO:0006810|GO:0016020 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 39 48 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 PRINTS PR00359 B-class P450 signature 37 46 1.1E-6 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 PRINTS PR00359 B-class P450 signature 46 57 1.1E-6 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 PRINTS PR00359 B-class P450 signature 16 31 1.1E-6 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 Pfam PF00067 Cytochrome P450 23 66 8.6E-9 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 Gene3D G3DSA:1.10.630.10 3 97 1.3E-30 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42590 5c3a5f5db47a9afe09864c801aa2fe3d 97 SUPERFAMILY SSF48264 3 97 3.93E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24690 4e61433ef4325c9d846a797215327fcb 200 Gene3D G3DSA:3.90.950.10 6 194 1.9E-59 T 17-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like SHXM_RS24690 4e61433ef4325c9d846a797215327fcb 200 PIRSF PIRSF006305 1 197 2.0E-43 T 17-03-2017 IPR003697 Maf-like protein GO:0005737 SHXM_RS24690 4e61433ef4325c9d846a797215327fcb 200 TIGRFAM TIGR00172 maf: septum formation protein Maf 5 188 4.4E-47 T 17-03-2017 IPR003697 Maf-like protein GO:0005737 SHXM_RS24690 4e61433ef4325c9d846a797215327fcb 200 Hamap MF_00528 Septum formation protein Maf [maf]. 6 195 28.492 T 17-03-2017 IPR003697 Maf-like protein GO:0005737 SHXM_RS24690 4e61433ef4325c9d846a797215327fcb 200 Pfam PF02545 Maf-like protein 7 190 1.0E-46 T 17-03-2017 IPR003697 Maf-like protein GO:0005737 SHXM_RS24690 4e61433ef4325c9d846a797215327fcb 200 SUPERFAMILY SSF52972 5 190 1.96E-52 T 17-03-2017 IPR029001 Inosine triphosphate pyrophosphatase-like SHXM_RS20830 5eec8a0cfe09fec12298aa7cd67d3795 288 SUPERFAMILY SSF100950 9 253 1.95E-65 T 17-03-2017 SHXM_RS20830 5eec8a0cfe09fec12298aa7cd67d3795 288 Pfam PF01144 Coenzyme A transferase 17 224 3.5E-36 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS20830 5eec8a0cfe09fec12298aa7cd67d3795 288 Gene3D G3DSA:3.40.810.20 9 252 1.2E-87 T 17-03-2017 SHXM_RS20830 5eec8a0cfe09fec12298aa7cd67d3795 288 SMART SM00882 15 225 4.8E-30 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS10830 17ee1aa0385a808620de27d7a526dc01 683 Gene3D G3DSA:3.40.50.980 27 124 5.9E-15 T 17-03-2017 SHXM_RS10830 17ee1aa0385a808620de27d7a526dc01 683 SUPERFAMILY SSF56801 14 437 8.5E-74 T 17-03-2017 SHXM_RS10830 17ee1aa0385a808620de27d7a526dc01 683 ProSitePatterns PS00455 Putative AMP-binding domain signature. 114 125 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS10830 17ee1aa0385a808620de27d7a526dc01 683 Gene3D G3DSA:2.30.38.10 284 347 5.1E-16 T 17-03-2017 SHXM_RS10830 17ee1aa0385a808620de27d7a526dc01 683 Pfam PF00501 AMP-binding enzyme 18 352 6.6E-52 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10830 17ee1aa0385a808620de27d7a526dc01 683 Gene3D G3DSA:3.40.50.980 125 266 7.6E-29 T 17-03-2017 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 33 62 - T 17-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 SUPERFAMILY SSF51230 8 100 1.16E-26 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 Gene3D G3DSA:3.30.559.10 235 473 4.1E-84 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 SUPERFAMILY SSF52777 235 473 5.34E-77 T 17-03-2017 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 244 473 1.6E-78 T 17-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 SUPERFAMILY SSF47005 183 224 1.96E-10 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 Pfam PF02817 e3 binding domain 186 220 1.0E-13 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 Pfam PF00364 Biotin-requiring enzyme 10 80 5.3E-23 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 Gene3D G3DSA:2.40.50.100 9 100 2.0E-27 T 17-03-2017 SHXM_RS28445 454ed9aab6500a565705d69d6e8f3314 476 Gene3D G3DSA:4.10.320.10 184 230 2.9E-16 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 Gene3D G3DSA:3.40.50.1820 6 344 1.2E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 Pfam PF00561 alpha/beta hydrolase fold 31 133 4.8E-23 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 SUPERFAMILY SSF53474 300 344 3.38E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 SUPERFAMILY SSF53474 177 268 3.38E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 SUPERFAMILY SSF53474 7 137 3.38E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 PRINTS PR00111 Alpha/beta hydrolase fold signature 55 70 2.7E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 PRINTS PR00111 Alpha/beta hydrolase fold signature 115 128 2.7E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS49585 bf5cfe82d2d10ae20cb625275c8ccad8 345 PRINTS PR00111 Alpha/beta hydrolase fold signature 101 114 2.7E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34880 a28d3c1081c076f9aa38d063f81241e7 201 Gene3D G3DSA:3.40.50.720 1 196 1.0E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34880 a28d3c1081c076f9aa38d063f81241e7 201 SUPERFAMILY SSF51735 2 187 1.93E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34880 a28d3c1081c076f9aa38d063f81241e7 201 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 2 19 1.9E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34880 a28d3c1081c076f9aa38d063f81241e7 201 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 127 146 1.9E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34880 a28d3c1081c076f9aa38d063f81241e7 201 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 164 1.9E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34880 a28d3c1081c076f9aa38d063f81241e7 201 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 26 163 2.2E-18 T 17-03-2017 SHXM_RS13200 bd043da100c69806190d3521dbad2cb9 455 SMART SM01230 120 373 1.2E-107 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS13200 bd043da100c69806190d3521dbad2cb9 455 SUPERFAMILY SSF54368 10 119 3.92E-16 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS13200 bd043da100c69806190d3521dbad2cb9 455 Pfam PF00120 Glutamine synthetase, catalytic domain 121 448 6.6E-105 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS13200 bd043da100c69806190d3521dbad2cb9 455 Gene3D G3DSA:3.10.20.70 10 123 4.2E-9 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS13200 bd043da100c69806190d3521dbad2cb9 455 Gene3D G3DSA:3.30.590.10 124 442 3.1E-100 T 17-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 SHXM_RS13200 bd043da100c69806190d3521dbad2cb9 455 SUPERFAMILY SSF55931 122 453 2.75E-102 T 17-03-2017 SHXM_RS07885 0a4379fc7b9ff6db0f8d5e5d328bda8c 262 ProSitePatterns PS00211 ABC transporters family signature. 158 172 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS07885 0a4379fc7b9ff6db0f8d5e5d328bda8c 262 PIRSF PIRSF039085 9 262 2.3E-112 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS07885 0a4379fc7b9ff6db0f8d5e5d328bda8c 262 Gene3D G3DSA:3.40.50.300 12 258 3.2E-87 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07885 0a4379fc7b9ff6db0f8d5e5d328bda8c 262 SMART SM00382 37 234 8.2E-22 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07885 0a4379fc7b9ff6db0f8d5e5d328bda8c 262 Pfam PF00005 ABC transporter 28 186 6.5E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS07885 0a4379fc7b9ff6db0f8d5e5d328bda8c 262 SUPERFAMILY SSF52540 13 256 4.84E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 ProSitePatterns PS00211 ABC transporters family signature. 460 474 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 Pfam PF00005 ABC transporter 365 488 5.7E-20 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 Pfam PF00005 ABC transporter 20 188 9.3E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 SMART SM00382 369 532 9.0E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 SMART SM00382 29 233 4.8E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 SUPERFAMILY SSF52540 365 536 2.46E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 Gene3D G3DSA:3.40.50.300 4 270 2.4E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 Gene3D G3DSA:3.40.50.300 365 530 8.4E-30 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS37410 98a28f271432c03d2449b8965ecfc0fd 548 SUPERFAMILY SSF52540 5 230 1.67E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17040 1e8fd29435721c3972ffd5f0eaf5b191 238 Pfam PF01553 Acyltransferase 46 165 4.0E-16 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS17040 1e8fd29435721c3972ffd5f0eaf5b191 238 Gene3D G3DSA:3.40.1130.10 41 168 4.6E-15 T 17-03-2017 SHXM_RS17040 1e8fd29435721c3972ffd5f0eaf5b191 238 SUPERFAMILY SSF69593 35 222 1.26E-32 T 17-03-2017 SHXM_RS17040 1e8fd29435721c3972ffd5f0eaf5b191 238 SMART SM00563 58 168 1.9E-21 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS04510 3d74e42a9d33a539a511d74faffab3a7 336 Pfam PF07859 alpha/beta hydrolase fold 104 309 2.3E-50 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS04510 3d74e42a9d33a539a511d74faffab3a7 336 SUPERFAMILY SSF53474 94 334 1.47E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04510 3d74e42a9d33a539a511d74faffab3a7 336 Gene3D G3DSA:3.40.50.1820 64 335 1.7E-69 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33405 28f544dc46d4e84bf9b5c3f477dd23d1 274 SUPERFAMILY SSF47413 12 74 1.58E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33405 28f544dc46d4e84bf9b5c3f477dd23d1 274 Gene3D G3DSA:1.10.260.40 3 68 2.7E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33405 28f544dc46d4e84bf9b5c3f477dd23d1 274 SMART SM00530 17 72 6.6E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS33405 28f544dc46d4e84bf9b5c3f477dd23d1 274 Pfam PF13560 Helix-turn-helix domain 15 69 6.2E-13 T 17-03-2017 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.30.365.10 423 583 1.6E-26 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 SUPERFAMILY SSF54665 4 123 1.13E-27 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.30.365.10 257 283 9.5E-5 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.30.365.10 103 149 9.5E-5 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.90.1170.50 3 102 2.0E-25 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 20 114 4.9E-11 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 SUPERFAMILY SSF56003 107 714 7.98E-149 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 SMART SM01008 20 115 4.9E-23 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.30.365.10 584 714 2.0E-54 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.30.365.10 330 422 2.0E-54 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Gene3D G3DSA:3.30.365.10 150 250 1.2E-30 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS10390 bf1246fc4216a6433a4c9fd47da070b9 715 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 135 658 4.9E-114 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47310 8c13ab429aa5eac845b9e5589bdd9a7f 550 Gene3D G3DSA:3.30.470.20 135 294 5.1E-23 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS47310 8c13ab429aa5eac845b9e5589bdd9a7f 550 Pfam PF13535 ATP-grasp domain 165 299 1.5E-11 T 17-03-2017 SHXM_RS47310 8c13ab429aa5eac845b9e5589bdd9a7f 550 SMART SM01209 130 302 6.1E-5 T 17-03-2017 SHXM_RS47310 8c13ab429aa5eac845b9e5589bdd9a7f 550 Gene3D G3DSA:3.40.50.20 99 134 2.4E-8 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS47310 8c13ab429aa5eac845b9e5589bdd9a7f 550 SUPERFAMILY SSF56059 131 299 6.19E-27 T 17-03-2017 SHXM_RS05150 62428c6c9b714a2f3d532cf42c2279d2 242 Gene3D G3DSA:1.20.950.10 34 232 5.5E-12 T 17-03-2017 SHXM_RS05150 62428c6c9b714a2f3d532cf42c2279d2 242 Pfam PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 122 226 5.7E-6 T 17-03-2017 IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit GO:0016627 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05150 62428c6c9b714a2f3d532cf42c2279d2 242 TIGRFAM TIGR02046 sdhC_b558_fam: succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family 27 241 1.1E-75 T 17-03-2017 IPR011138 Succinate dehydrogenase cytochrome b558 subunit SHXM_RS05150 62428c6c9b714a2f3d532cf42c2279d2 242 SUPERFAMILY SSF81343 13 241 2.62E-51 T 17-03-2017 SHXM_RS07890 c427e3903155c8a15b16a59890a96da2 417 SUPERFAMILY SSF51556 371 416 4.76E-63 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS07890 c427e3903155c8a15b16a59890a96da2 417 SUPERFAMILY SSF51556 59 334 4.76E-63 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS07890 c427e3903155c8a15b16a59890a96da2 417 Gene3D G3DSA:3.20.20.140 56 341 2.7E-78 T 17-03-2017 SHXM_RS07890 c427e3903155c8a15b16a59890a96da2 417 Gene3D G3DSA:3.20.20.140 373 416 2.7E-78 T 17-03-2017 SHXM_RS07890 c427e3903155c8a15b16a59890a96da2 417 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 138 412 8.2E-67 T 17-03-2017 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533|Reactome: R-HSA-2142691|Reactome: R-HSA-5423646 SHXM_RS38440 6e2583380bcef951947c42f843eb5b24 303 Gene3D G3DSA:3.40.50.150 39 174 1.6E-5 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS38440 6e2583380bcef951947c42f843eb5b24 303 SUPERFAMILY SSF53335 42 174 1.55E-7 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS38440 6e2583380bcef951947c42f843eb5b24 303 Pfam PF13578 Methyltransferase domain 48 168 5.3E-13 T 17-03-2017 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 214 229 6.4E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 229 245 6.4E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 SUPERFAMILY SSF46689 199 245 5.82E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 Pfam PF12833 Helix-turn-helix domain 171 245 9.9E-23 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 SMART SM00342 163 245 1.6E-28 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 Gene3D G3DSA:2.60.120.10 6 87 1.8E-11 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 Gene3D G3DSA:1.10.10.60 201 245 4.4E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 SUPERFAMILY SSF51182 13 172 1.03E-19 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 Gene3D G3DSA:1.10.10.60 142 200 1.1E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS06605 9306f07a2b19b2a2806f4584b0ca0e4e 248 Pfam PF07883 Cupin domain 17 78 7.2E-7 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS13550 069f04a0b979ca3cd50b720f9671222c 201 PIRSF PIRSF034110 36 201 2.1E-33 T 17-03-2017 IPR009593 Protein of unknown function DUF1203 SHXM_RS13550 069f04a0b979ca3cd50b720f9671222c 201 Pfam PF06718 Protein of unknown function (DUF1203) 76 200 7.8E-35 T 17-03-2017 IPR009593 Protein of unknown function DUF1203 SHXM_RS31930 6f6289950bfab370370d53f6b95d5b9e 851 Gene3D G3DSA:3.40.710.10 519 729 1.3E-53 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS31930 6f6289950bfab370370d53f6b95d5b9e 851 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 611 624 4.0E-13 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS31930 6f6289950bfab370370d53f6b95d5b9e 851 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 527 538 4.0E-13 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS31930 6f6289950bfab370370d53f6b95d5b9e 851 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 584 601 4.0E-13 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS31930 6f6289950bfab370370d53f6b95d5b9e 851 SUPERFAMILY SSF56601 451 728 5.63E-40 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS31930 6f6289950bfab370370d53f6b95d5b9e 851 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 520 726 2.2E-31 T 17-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 SMART SM00866 101 251 1.2E-9 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 SUPERFAMILY SSF46785 2 70 1.79E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 Gene3D G3DSA:1.10.10.10 3 68 1.3E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 Pfam PF07702 UTRA domain 117 250 3.4E-14 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 SUPERFAMILY SSF64288 54 255 1.32E-22 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 Pfam PF00392 Bacterial regulatory proteins, gntR family 3 66 1.4E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 SMART SM00345 7 66 4.0E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26080 53f5da6c5a8edfc20e1614dbc1160c8b 261 Gene3D G3DSA:3.40.1410.10 69 253 8.3E-46 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 Pfam PF16198 tRNA pseudouridylate synthase B C-terminal domain 192 235 9.9E-12 T 17-03-2017 IPR032819 tRNA pseudouridylate synthase B, C-terminal Reactome: R-HSA-171319|Reactome: R-HSA-6790901 SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 Hamap MF_01080 tRNA pseudouridine synthase B [truB]. 12 310 17.029 T 17-03-2017 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 Pfam PF09142 tRNA Pseudouridine synthase II, C terminal 247 311 3.6E-16 T 17-03-2017 IPR015225 tRNA pseudouridine synthase II, TruB, subfamily 2, C-terminal GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 Pfam PF01509 TruB family pseudouridylate synthase (N terminal domain) 34 191 1.3E-46 T 17-03-2017 IPR002501 Pseudouridine synthase II, N-terminal GO:0006396 SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 TIGRFAM TIGR00431 TruB: tRNA pseudouridine(55) synthase 13 230 3.3E-65 T 17-03-2017 IPR014780 tRNA pseudouridine synthase II, TruB GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 SUPERFAMILY SSF88697 247 310 1.69E-8 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS36940 8ebd0baba5769c0a8e2231926bc3a8df 311 SUPERFAMILY SSF55120 13 237 8.16E-67 T 17-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS34520 a1f84324855647e811d9e6c7e88405fb 388 SUPERFAMILY SSF56601 53 357 2.65E-76 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS34520 a1f84324855647e811d9e6c7e88405fb 388 Pfam PF00144 Beta-lactamase 72 354 1.3E-59 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS34520 a1f84324855647e811d9e6c7e88405fb 388 Gene3D G3DSA:3.40.710.10 63 351 3.7E-78 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 SUPERFAMILY SSF46785 12 83 3.04E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 SUPERFAMILY SSF55781 102 248 1.11E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 SMART SM00346 12 101 3.5E-6 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 Pfam PF09339 IclR helix-turn-helix domain 14 61 1.6E-11 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 Pfam PF01614 Bacterial transcriptional regulator 129 248 1.5E-19 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 Gene3D G3DSA:3.30.450.40 79 248 3.2E-41 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS19640 92ad9b9818fc160aeb3913a81e046ad5 256 Gene3D G3DSA:1.10.10.10 5 69 3.3E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05290 13f0b936f4c350def8a1c518932f0021 360 SUPERFAMILY SSF51735 203 359 1.72E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05290 13f0b936f4c350def8a1c518932f0021 360 Gene3D G3DSA:3.40.50.720 206 341 5.1E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05290 13f0b936f4c350def8a1c518932f0021 360 Pfam PF08659 KR domain 206 360 3.7E-18 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05290 13f0b936f4c350def8a1c518932f0021 360 SUPERFAMILY SSF51735 21 193 5.12E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05290 13f0b936f4c350def8a1c518932f0021 360 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 206 360 2.7E-7 T 17-03-2017 SHXM_RS19925 1f2818a5710bf37022fa3c974cdc2d03 472 Gene3D G3DSA:3.30.559.10 15 194 2.4E-36 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS19925 1f2818a5710bf37022fa3c974cdc2d03 472 Gene3D G3DSA:3.30.559.10 235 445 9.7E-34 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS19925 1f2818a5710bf37022fa3c974cdc2d03 472 Pfam PF02458 Transferase family 19 443 2.0E-51 T 17-03-2017 IPR003480 Transferase GO:0016747 SHXM_RS19925 1f2818a5710bf37022fa3c974cdc2d03 472 SUPERFAMILY SSF52777 41 177 8.15E-7 T 17-03-2017 SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 SUPERFAMILY SSF103473 22 211 4.97E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 SUPERFAMILY SSF103473 487 513 4.97E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 SUPERFAMILY SSF103473 263 435 4.97E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 30 504 1.8E-73 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 Gene3D G3DSA:1.20.1250.20 272 436 1.9E-24 T 17-03-2017 SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 Gene3D G3DSA:1.20.1250.20 488 509 1.9E-24 T 17-03-2017 SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 Gene3D G3DSA:1.20.1250.20 28 208 9.3E-33 T 17-03-2017 SHXM_RS49330 c0b1c3b9bcb0effc847b254975bbd97d 532 Pfam PF07690 Major Facilitator Superfamily 33 425 3.0E-50 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS03485 6988a36f0ce168572a0a96a2b165136f 215 Pfam PF13649 Methyltransferase domain 50 143 9.1E-17 T 17-03-2017 SHXM_RS03485 6988a36f0ce168572a0a96a2b165136f 215 SUPERFAMILY SSF53335 14 174 2.59E-36 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03485 6988a36f0ce168572a0a96a2b165136f 215 Gene3D G3DSA:3.40.50.150 29 214 3.0E-39 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14120 104167484c5508527d750d97898a8b71 571 SUPERFAMILY SSF52467 195 386 1.51E-34 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14120 104167484c5508527d750d97898a8b71 571 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 441 460 - T 17-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SHXM_RS14120 104167484c5508527d750d97898a8b71 571 SUPERFAMILY SSF52518 381 563 6.25E-48 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14120 104167484c5508527d750d97898a8b71 571 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 405 553 2.2E-28 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS14120 104167484c5508527d750d97898a8b71 571 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 200 326 1.1E-24 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS14120 104167484c5508527d750d97898a8b71 571 Gene3D G3DSA:3.40.50.970 5 183 4.9E-58 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14120 104167484c5508527d750d97898a8b71 571 Gene3D G3DSA:3.40.50.1220 191 333 1.2E-35 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14120 104167484c5508527d750d97898a8b71 571 Gene3D G3DSA:3.40.50.970 353 562 1.2E-51 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14120 104167484c5508527d750d97898a8b71 571 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 10 176 2.6E-49 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS14120 104167484c5508527d750d97898a8b71 571 SUPERFAMILY SSF52518 9 181 9.51E-46 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS39725 ee5c9f519b5fe3968a3002a90df83629 273 Gene3D G3DSA:1.20.1250.20 122 251 4.8E-16 T 17-03-2017 SHXM_RS39725 ee5c9f519b5fe3968a3002a90df83629 273 Gene3D G3DSA:1.20.1250.20 29 121 1.5E-14 T 17-03-2017 SHXM_RS39725 ee5c9f519b5fe3968a3002a90df83629 273 Pfam PF07690 Major Facilitator Superfamily 114 263 6.2E-13 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS39725 ee5c9f519b5fe3968a3002a90df83629 273 SUPERFAMILY SSF103473 27 129 2.75E-17 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS39725 ee5c9f519b5fe3968a3002a90df83629 273 SUPERFAMILY SSF103473 127 258 9.55E-16 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS15770 468828680f12f9a37fc58748cd9aeb55 197 SUPERFAMILY SSF53335 18 174 8.93E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS15770 468828680f12f9a37fc58748cd9aeb55 197 Gene3D G3DSA:3.40.50.150 19 183 1.2E-20 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS15770 468828680f12f9a37fc58748cd9aeb55 197 Pfam PF13649 Methyltransferase domain 35 127 1.7E-11 T 17-03-2017 SHXM_RS19370 c6b68c225fceb671e681d5218a2cf011 401 SUPERFAMILY SSF103473 3 376 3.01E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19370 c6b68c225fceb671e681d5218a2cf011 401 Gene3D G3DSA:1.20.1250.20 5 180 3.9E-29 T 17-03-2017 SHXM_RS19370 c6b68c225fceb671e681d5218a2cf011 401 Gene3D G3DSA:1.20.1250.20 197 379 7.2E-17 T 17-03-2017 SHXM_RS19370 c6b68c225fceb671e681d5218a2cf011 401 Pfam PF07690 Major Facilitator Superfamily 9 339 6.5E-46 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS49715 6bd8bbd960371e83d474bf0d5916693a 213 SUPERFAMILY SSF52540 21 71 6.83E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49715 6bd8bbd960371e83d474bf0d5916693a 213 Gene3D G3DSA:3.40.50.300 19 70 8.0E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49715 6bd8bbd960371e83d474bf0d5916693a 213 Pfam PF00005 ABC transporter 22 50 4.6E-5 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 TIGRFAM TIGR01141 hisC: histidinol-phosphate transaminase 11 354 7.3E-87 T 17-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 SUPERFAMILY SSF53383 29 350 5.98E-76 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 Gene3D G3DSA:3.40.640.10 47 245 2.5E-45 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 Hamap MF_01513 Putative phenylalanine aminotransferase [pat]. 8 357 48.95 T 17-03-2017 IPR024892 Putative phenylalanine aminotransferase SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 220 229 - T 17-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 Hamap MF_01023 Histidinol-phosphate aminotransferase [hisC]. 7 356 49.064 T 17-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 Gene3D G3DSA:3.90.1150.10 246 355 3.7E-31 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS27805 1c4f8a25de76ab8d2699e54ae4f8eb28 359 Pfam PF00155 Aminotransferase class I and II 32 346 4.8E-48 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Gene3D G3DSA:3.30.450.40 361 556 4.0E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SUPERFAMILY SSF81606 590 801 3.92E-11 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SUPERFAMILY SSF55781 428 552 2.84E-14 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Gene3D G3DSA:3.30.450.20 63 200 6.3E-43 T 17-03-2017 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Gene3D G3DSA:3.30.450.20 239 342 2.6E-7 T 17-03-2017 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Pfam PF01590 GAF domain 476 548 4.6E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SUPERFAMILY SSF55785 237 341 3.02E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SUPERFAMILY SSF55874 846 924 9.34E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 603 802 1.2E-55 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SUPERFAMILY SSF103190 70 198 5.49E-34 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Pfam PF17203 Single cache domain 3 67 196 4.5E-26 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Pfam PF13581 Histidine kinase-like ATPase domain 816 923 6.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 Pfam PF08448 PAS fold 248 344 1.8E-5 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SMART SM00331 576 802 1.5E-41 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29075 2cf28ee0f77b0065652788f5178539e3 938 SMART SM00065 362 558 1.8E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 11 330 55.759 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 Gene3D G3DSA:3.40.47.10 12 169 1.2E-53 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 240 328 2.4E-28 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 115 192 3.0E-24 T 17-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 SUPERFAMILY SSF53901 12 328 9.78E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 Gene3D G3DSA:3.40.47.10 170 328 6.2E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39695 e75fc167decc7af06bb6b3bc78d4a95f 331 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 12 329 8.6E-100 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 Gene3D G3DSA:3.90.640.10 181 253 4.2E-32 T 17-03-2017 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 Gene3D G3DSA:3.30.420.40 6 153 5.5E-48 T 17-03-2017 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 TIGRFAM TIGR00904 mreB: cell shape determining protein, MreB/Mrl family 6 330 1.7E-153 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 Gene3D G3DSA:3.30.420.40 154 180 5.2E-36 T 17-03-2017 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 Gene3D G3DSA:3.30.420.40 257 311 5.2E-36 T 17-03-2017 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 43 61 2.4E-62 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 181 201 2.4E-62 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 294 320 2.4E-62 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 63 86 2.4E-62 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 126 145 2.4E-62 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 Pfam PF06723 MreB/Mbl protein 6 330 5.8E-156 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 SUPERFAMILY SSF53067 144 322 1.79E-51 T 17-03-2017 SHXM_RS21650 fa9b0bb21880d9184cd7c7d67ba08f8c 339 SUPERFAMILY SSF53067 5 142 1.58E-42 T 17-03-2017 SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 170 189 7.4E-5 T 17-03-2017 SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 PRINTS PR01023 Sodium-type flagellar protein MotY precursor signature 190 210 7.4E-5 T 17-03-2017 SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 SUPERFAMILY SSF103088 97 207 6.02E-27 T 17-03-2017 IPR006665 OmpA-like domain SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 Pfam PF00691 OmpA family 107 201 7.6E-15 T 17-03-2017 IPR006665 OmpA-like domain SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 Gene3D G3DSA:3.30.1330.60 95 207 1.3E-28 T 17-03-2017 IPR006665 OmpA-like domain SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 PRINTS PR01021 OMPA domain signature 152 168 3.4E-6 T 17-03-2017 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 PRINTS PR01021 OMPA domain signature 137 152 3.4E-6 T 17-03-2017 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SHXM_RS33490 e6f9181a2efb51dc43143291f2fd580d 211 PRINTS PR01021 OMPA domain signature 107 129 3.4E-6 T 17-03-2017 IPR006664 Outer membrane protein, bacterial GO:0009279|GO:0016021 SHXM_RS25485 cb518120d8e0e6b98471c70454b84c8c 125 Pfam PF13466 STAS domain 11 81 2.0E-12 T 17-03-2017 IPR002645 STAS domain SHXM_RS25485 cb518120d8e0e6b98471c70454b84c8c 125 Gene3D G3DSA:3.30.750.24 3 111 1.8E-35 T 17-03-2017 IPR002645 STAS domain SHXM_RS25485 cb518120d8e0e6b98471c70454b84c8c 125 SUPERFAMILY SSF52091 4 111 3.14E-22 T 17-03-2017 IPR002645 STAS domain SHXM_RS25485 cb518120d8e0e6b98471c70454b84c8c 125 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 5 105 3.1E-17 T 17-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 SUPERFAMILY SSF52768 15 309 2.16E-97 T 17-03-2017 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 ProSitePatterns PS01053 Arginase family signature. 237 258 - T 17-03-2017 IPR020855 Ureohydrolase, manganese-binding site GO:0016813|GO:0046872 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 PRINTS PR00116 Arginase signature 121 136 1.0E-14 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 PRINTS PR00116 Arginase signature 234 263 1.0E-14 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 Pfam PF00491 Arginase family 35 305 4.5E-90 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 TIGRFAM TIGR01230 agmatinase: agmatinase 34 307 6.2E-69 T 17-03-2017 IPR005925 Agmatinase-related KEGG: 00330+3.5.3.11|MetaCyc: PWY-40|MetaCyc: PWY-6305|Reactome: R-HSA-351143 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 PIRSF PIRSF036979 19 313 1.5E-107 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS46375 ef4bbe4699d199714ff009b208e7c322 325 Gene3D G3DSA:3.40.800.10 10 311 5.6E-116 T 17-03-2017 IPR023696 Ureohydrolase domain SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 350 573 8.3E-46 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 Gene3D G3DSA:3.30.450.40 143 300 6.4E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 Gene3D G3DSA:3.30.450.20 2 115 4.5E-8 T 17-03-2017 SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 SUPERFAMILY SSF81606 337 548 1.67E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 SUPERFAMILY SSF55781 172 306 5.23E-14 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 SMART SM00331 321 573 8.4E-40 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 Pfam PF13581 Histidine kinase-like ATPase domain 597 706 7.1E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28525 df33e45f5fcaff95e1181d5fe88ff740 728 Pfam PF13185 GAF domain 183 293 8.1E-11 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS47895 69e5a07356bac0110ef7317bf7080358 161 SMART SM00347 35 133 1.0E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47895 69e5a07356bac0110ef7317bf7080358 161 Pfam PF12802 MarR family 41 96 8.2E-12 T 17-03-2017 SHXM_RS47895 69e5a07356bac0110ef7317bf7080358 161 SUPERFAMILY SSF46785 11 145 8.86E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47895 69e5a07356bac0110ef7317bf7080358 161 Gene3D G3DSA:1.10.10.10 14 145 4.3E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32840 c244d8282b1eee198b3c8390e3aef4d1 1076 Pfam PF14440 Xanthomonas XOO_2897-like deaminase 756 855 7.7E-34 T 17-03-2017 IPR032722 Deaminase, Xanthomonas XOO_2897-like SHXM_RS32840 c244d8282b1eee198b3c8390e3aef4d1 1076 Pfam PF14435 SUKH-4 immunity protein 895 1070 9.0E-43 T 17-03-2017 IPR025851 SUKH-4 immunity protein SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 Gene3D G3DSA:2.40.10.10 72 127 2.2E-13 T 17-03-2017 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 SMART SM00020 41 256 5.1E-62 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 SUPERFAMILY SSF50494 42 257 1.31E-59 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 Pfam PF00089 Trypsin 42 254 1.1E-49 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 74 79 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 206 217 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 Gene3D G3DSA:2.40.10.10 42 71 8.0E-13 T 17-03-2017 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 Gene3D G3DSA:2.40.10.10 128 257 8.4E-38 T 17-03-2017 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 205 217 3.5E-12 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 119 133 3.5E-12 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS18240 d5eafd4429077363942c5a0d4547bdc7 265 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 64 79 3.5E-12 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS43885 4212f4480d2f3403eccc2a07f9a15461 148 SUPERFAMILY SSF51261 3 134 2.09E-35 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS43885 4212f4480d2f3403eccc2a07f9a15461 148 Pfam PF00358 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 3 124 2.3E-37 T 17-03-2017 IPR001127 Phosphotransferase system, sugar-specific permease EIIA type 1 GO:0009401 SHXM_RS43885 4212f4480d2f3403eccc2a07f9a15461 148 TIGRFAM TIGR00830 PTBA: PTS system, glucose subfamily, IIA component 4 122 9.7E-29 T 17-03-2017 IPR001127 Phosphotransferase system, sugar-specific permease EIIA type 1 GO:0009401 SHXM_RS43885 4212f4480d2f3403eccc2a07f9a15461 148 Gene3D G3DSA:2.70.70.10 3 148 8.2E-44 T 17-03-2017 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 Gene3D G3DSA:3.30.70.420 117 218 4.4E-32 T 17-03-2017 IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain GO:0050662 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 Gene3D G3DSA:3.90.770.10 228 370 2.8E-82 T 17-03-2017 IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain GO:0004420|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 Gene3D G3DSA:3.90.770.10 7 116 2.8E-82 T 17-03-2017 IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain GO:0004420|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 Pfam PF00368 Hydroxymethylglutaryl-coenzyme A reductase 15 381 1.0E-107 T 17-03-2017 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II GO:0004420|GO:0015936|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 ProSitePatterns PS00066 Hydroxymethylglutaryl-coenzyme A reductases signature 1. 175 189 - T 17-03-2017 IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site GO:0004420|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature 308 329 4.4E-8 T 17-03-2017 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II GO:0004420|GO:0015936|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature 77 97 4.4E-8 T 17-03-2017 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II GO:0004420|GO:0015936|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature 173 191 4.4E-8 T 17-03-2017 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II GO:0004420|GO:0015936|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 PRINTS PR00071 Hydroxymethylglutaryl-coenzyme A reductase signature 50 71 4.4E-8 T 17-03-2017 IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II GO:0004420|GO:0015936|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 SUPERFAMILY SSF55035 111 218 6.02E-27 T 17-03-2017 IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain GO:0050662 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 ProSitePatterns PS00318 Hydroxymethylglutaryl-coenzyme A reductases signature 2. 320 327 - T 17-03-2017 IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site GO:0004420|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 ProSitePatterns PS01192 Hydroxymethylglutaryl-coenzyme A reductases signature 3. 366 379 - T 17-03-2017 IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site GO:0004420|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 SUPERFAMILY SSF56542 223 422 1.96E-93 T 17-03-2017 IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain GO:0015936|GO:0016616|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 SUPERFAMILY SSF56542 7 119 1.96E-93 T 17-03-2017 IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain GO:0015936|GO:0016616|GO:0050662|GO:0055114 KEGG: 00900+1.1.1.34|MetaCyc: PWY-6174|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-922|Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS00730 ec128878d2a2204a6f085d0d89ddba08 424 TIGRFAM TIGR00532 HMG_CoA_R_NAD: hydroxymethylglutaryl-CoA reductase, degradative 3 381 2.8E-124 T 17-03-2017 IPR004553 Hydroxymethylglutaryl-CoA reductase, bacterial-type GO:0015936|GO:0016616|GO:0050662 SHXM_RS15275 238cc461d172b21ef3f05e99dfa3a607 133 Pfam PF01042 Endoribonuclease L-PSP 19 127 3.1E-20 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS15275 238cc461d172b21ef3f05e99dfa3a607 133 Gene3D G3DSA:3.30.1330.40 7 126 7.4E-31 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS15275 238cc461d172b21ef3f05e99dfa3a607 133 SUPERFAMILY SSF55298 17 127 3.14E-28 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 Gene3D G3DSA:3.40.50.1820 5 263 2.6E-69 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 Pfam PF00561 alpha/beta hydrolase fold 21 119 6.9E-21 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00111 Alpha/beta hydrolase fold signature 90 103 1.4E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00111 Alpha/beta hydrolase fold signature 207 221 1.4E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00111 Alpha/beta hydrolase fold signature 46 61 1.4E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00111 Alpha/beta hydrolase fold signature 104 117 1.4E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 SUPERFAMILY SSF53474 6 262 2.16E-69 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00412 Epoxide hydrolase signature 26 44 3.1E-13 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00412 Epoxide hydrolase signature 104 117 3.1E-13 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00412 Epoxide hydrolase signature 238 260 3.1E-13 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09510 ef3cc95d81a1d2d5f602c0597b774da2 272 PRINTS PR00412 Epoxide hydrolase signature 46 61 3.1E-13 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 PIRSF PIRSF000077 2 108 7.4E-42 T 17-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 TIGRFAM TIGR01068 thioredoxin: thioredoxin 9 106 2.7E-36 T 17-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 PRINTS PR00421 Thioredoxin family signature 72 83 1.0E-7 T 17-03-2017 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 PRINTS PR00421 Thioredoxin family signature 32 41 1.0E-7 T 17-03-2017 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 PRINTS PR00421 Thioredoxin family signature 24 32 1.0E-7 T 17-03-2017 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 Gene3D G3DSA:3.40.30.10 3 105 8.7E-37 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 Pfam PF00085 Thioredoxin 6 104 9.7E-33 T 17-03-2017 IPR013766 Thioredoxin domain GO:0045454 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 ProSitePatterns PS00194 Thioredoxin family active site. 25 43 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS28070 1aa88f7dc9752a0c91c7e7d1555b6d6f 109 SUPERFAMILY SSF52833 5 107 9.0E-37 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 SUPERFAMILY SSF51905 340 423 7.22E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 SUPERFAMILY SSF51905 10 225 7.22E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Pfam PF01571 Aminomethyltransferase folate-binding domain 437 708 1.0E-74 T 17-03-2017 IPR006222 Glycine cleavage T-protein-like, N-terminal SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.30.9.10 225 339 9.9E-55 T 17-03-2017 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.30.9.10 92 144 9.9E-55 T 17-03-2017 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.50.50.60 9 81 1.5E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.50.50.60 145 224 1.5E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.50.50.60 340 420 1.5E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.30.1360.120 589 685 5.9E-34 T 17-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.30.1360.120 432 506 5.9E-34 T 17-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 SUPERFAMILY SSF101790 732 818 1.96E-23 T 17-03-2017 IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:2.40.30.110 730 805 7.9E-28 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 SUPERFAMILY SSF103025 429 723 1.05E-93 T 17-03-2017 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Pfam PF01266 FAD dependent oxidoreductase 11 376 5.2E-48 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Gene3D G3DSA:3.30.70.1400 507 583 7.3E-19 T 17-03-2017 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 SUPERFAMILY SSF54373 225 339 8.63E-31 T 17-03-2017 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 714 806 1.7E-19 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS43760 52ba816e10d79cdaee309e2ae765233f 819 Pfam PF16350 FAD dependent oxidoreductase central domain 379 434 9.1E-19 T 17-03-2017 IPR032503 FAD dependent oxidoreductase, central domain SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 Pfam PF12833 Helix-turn-helix domain 236 315 1.1E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 Pfam PF14525 AraC-binding-like domain 20 195 2.1E-22 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 299 315 9.5E-6 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 284 299 9.5E-6 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 Gene3D G3DSA:1.10.10.60 210 265 1.4E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 SUPERFAMILY SSF46689 266 316 1.8E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 266 311 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 SMART SM00342 230 315 7.8E-25 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS31835 e72082a910f2db13f487ffcbb6178fa4 348 Gene3D G3DSA:1.10.10.60 266 316 7.4E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 Pfam PF13185 GAF domain 272 364 2.0E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 420 606 2.4E-44 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 SUPERFAMILY SSF55781 239 375 4.42E-17 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 Gene3D G3DSA:3.30.450.40 215 378 9.6E-15 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 SMART SM00065 218 373 9.5E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 Gene3D G3DSA:3.30.565.10 627 741 1.6E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 SUPERFAMILY SSF81606 410 603 1.23E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 Pfam PF13581 Histidine kinase-like ATPase domain 629 739 3.3E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 Gene3D G3DSA:3.30.450.40 21 163 1.6E-5 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 SMART SM00331 394 606 1.3E-26 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 SUPERFAMILY SSF55781 25 163 6.76E-8 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00995 22b896a9a3ab9b0669ff8a92604f8d5a 747 SUPERFAMILY SSF55874 649 741 1.27E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS48475 4c4c3a7364ab2ea7c800de6f4a536a7f 125 SUPERFAMILY SSF54909 11 109 4.99E-21 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS48475 4c4c3a7364ab2ea7c800de6f4a536a7f 125 Gene3D G3DSA:3.30.70.1060 12 109 2.9E-33 T 17-03-2017 SHXM_RS48475 4c4c3a7364ab2ea7c800de6f4a536a7f 125 Pfam PF03795 YCII-related domain 13 105 1.7E-11 T 17-03-2017 IPR005545 YCII-related SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 Pfam PF00005 ABC transporter 36 193 3.8E-23 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 Gene3D G3DSA:3.40.50.300 7 272 2.6E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 SUPERFAMILY SSF52540 16 264 6.52E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 SMART SM00382 44 243 3.8E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 245 309 3.1E-19 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 ProSitePatterns PS00211 ABC transporters family signature. 166 180 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS45545 ae8f788bfdd7ed061a9f19342f08d99d 336 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 244 329 1.2E-26 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 SMART SM00637 359 454 1.6E-19 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 PRINTS PR00134 Glycosyl hydrolase family 10 signature 121 133 4.5E-18 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 PRINTS PR00134 Glycosyl hydrolase family 10 signature 238 250 4.5E-18 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 PRINTS PR00134 Glycosyl hydrolase family 10 signature 163 174 4.5E-18 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 PRINTS PR00134 Glycosyl hydrolase family 10 signature 209 220 4.5E-18 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 SUPERFAMILY SSF49384 356 451 1.74E-18 T 17-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 SMART SM00633 90 346 7.8E-137 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 Pfam PF00331 Glycosyl hydrolase family 10 51 344 8.9E-118 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 Gene3D G3DSA:2.60.40.290 358 451 9.2E-21 T 17-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 Gene3D G3DSA:3.20.20.80 51 348 3.4E-122 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 ProSitePatterns PS00591 Glycosyl hydrolases family 10 (GH10) active site. 272 282 - T 17-03-2017 IPR031158 Glycosyl hydrolases family 10, active site MetaCyc: PWY-6784 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 Pfam PF00553 Cellulose binding domain 359 450 2.1E-11 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS11240 2f4b2c3c9884a960412b369e548f0155 457 SUPERFAMILY SSF51445 52 347 1.53E-115 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 Gene3D G3DSA:3.40.190.10 86 187 8.2E-20 T 17-03-2017 SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 SUPERFAMILY SSF46785 2 111 4.03E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 64 6.1E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 Gene3D G3DSA:3.40.190.10 188 241 1.2E-7 T 17-03-2017 SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 Gene3D G3DSA:1.10.10.10 5 81 8.8E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 Pfam PF03466 LysR substrate binding domain 88 280 2.8E-28 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 SUPERFAMILY SSF53850 88 284 9.1E-26 T 17-03-2017 SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 7.9E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 7.9E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49930 35c8a0c15edd3b6e90e5ee4d402e3ae2 313 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 7.9E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Gene3D G3DSA:1.10.1040.10 508 607 8.7E-12 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Pfam PF00378 Enoyl-CoA hydratase/isomerase 16 209 4.3E-31 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Gene3D G3DSA:3.40.50.720 319 507 1.6E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 325 503 5.3E-64 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Gene3D G3DSA:3.90.226.10 5 209 1.3E-57 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Gene3D G3DSA:3.90.226.10 243 302 1.3E-57 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 SUPERFAMILY SSF51735 322 503 3.86E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 SUPERFAMILY SSF48179 669 760 6.8E-16 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 506 606 8.4E-18 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 Gene3D G3DSA:1.10.1040.10 683 759 5.9E-8 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 SUPERFAMILY SSF48179 505 617 1.45E-14 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS13525 5dc08fdad21b3a7b9d405ca453dd0abf 762 SUPERFAMILY SSF52096 6 314 4.06E-62 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47165 8db575c86f8562da946368df72716687 146 SUPERFAMILY SSF161098 37 146 9.48E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47165 8db575c86f8562da946368df72716687 146 Gene3D G3DSA:1.10.3720.10 36 146 7.1E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14335 65df4e90d1e3ea43bcc3d804baa54737 258 Pfam PF10099 Anti-sigma-K factor rskA 58 252 3.4E-38 T 17-03-2017 IPR018764 Anti-sigma K factor RskA GO:0005886|GO:0016021 SHXM_RS14335 65df4e90d1e3ea43bcc3d804baa54737 258 Pfam PF13490 Putative zinc-finger 11 37 2.6E-5 T 17-03-2017 IPR027383 Putative zinc-finger SHXM_RS43555 083ce72de064d225c2638b6b5f557fa9 138 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 6 132 3.9E-14 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS43555 083ce72de064d225c2638b6b5f557fa9 138 Gene3D G3DSA:3.10.180.10 6 135 7.9E-33 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS43555 083ce72de064d225c2638b6b5f557fa9 138 SUPERFAMILY SSF54593 8 136 8.06E-28 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Gene3D G3DSA:3.30.379.10 48 189 1.9E-39 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 SUPERFAMILY SSF51445 195 717 2.74E-212 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Gene3D G3DSA:3.90.1330.10 516 715 1.2E-69 T 17-03-2017 IPR011099 Glycosyl hydrolase family 67, C-terminal GO:0005576|GO:0045493|GO:0046559 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 SUPERFAMILY SSF49785 829 924 1.36E-5 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Pfam PF07488 Glycosyl hydrolase family 67 middle domain 177 493 3.0E-139 T 17-03-2017 IPR011100 Glycosyl hydrolase family 67, catalytic domain GO:0005576|GO:0045493|GO:0046559 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Gene3D G3DSA:3.20.20.80 195 514 1.9E-144 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 SUPERFAMILY SSF55545 47 192 1.23E-32 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Gene3D G3DSA:2.60.120.360 828 967 4.2E-5 T 17-03-2017 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Pfam PF03648 Glycosyl hydrolase family 67 N-terminus 52 173 9.6E-22 T 17-03-2017 IPR005154 Alpha glucuronidase, N-terminal GO:0045493|GO:0046559 SHXM_RS02095 bb80861358a863844f7a422f90f40214 975 Pfam PF07477 Glycosyl hydrolase family 67 C-terminus 494 714 2.9E-76 T 17-03-2017 IPR011099 Glycosyl hydrolase family 67, C-terminal GO:0005576|GO:0045493|GO:0046559 SHXM_RS49505 0f20c77778f09e46b96ab9dd64e1ea3c 223 SUPERFAMILY SSF159709 35 218 1.83E-27 T 17-03-2017 SHXM_RS49505 0f20c77778f09e46b96ab9dd64e1ea3c 223 Pfam PF05845 Bacterial phosphonate metabolism protein (PhnH) 32 217 3.7E-34 T 17-03-2017 IPR008772 Bacterial phosphonate metabolism, PhnH GO:0019634 SHXM_RS49505 0f20c77778f09e46b96ab9dd64e1ea3c 223 TIGRFAM TIGR03292 PhnH_redo: phosphonate C-P lyase system protein PhnH 33 216 4.1E-33 T 17-03-2017 IPR008772 Bacterial phosphonate metabolism, PhnH GO:0019634 SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 SUPERFAMILY SSF48498 79 191 2.64E-24 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 Pfam PF13977 Bacterial transcriptional repressor 109 192 1.4E-8 T 17-03-2017 SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 58 6.0E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 ProSitePatterns PS01081 TetR-type HTH domain signature. 24 54 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 Gene3D G3DSA:1.10.10.60 1 64 5.2E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 SUPERFAMILY SSF46689 2 81 1.03E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47710 4534a38a07c8101b31486c60e1a402dc 192 Gene3D G3DSA:1.10.357.10 71 192 3.8E-23 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS26160 f14c3deebcb39ef1de82fdf3d9bd4356 443 Gene3D G3DSA:3.40.50.2000 207 410 1.3E-37 T 17-03-2017 SHXM_RS26160 f14c3deebcb39ef1de82fdf3d9bd4356 443 Pfam PF00534 Glycosyl transferases group 1 237 409 5.1E-30 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS26160 f14c3deebcb39ef1de82fdf3d9bd4356 443 SUPERFAMILY SSF53756 26 432 1.1E-82 T 17-03-2017 SHXM_RS26160 f14c3deebcb39ef1de82fdf3d9bd4356 443 Hamap MF_01695 D-inositol-3-phosphate glycosyltransferase [mshA]. 25 436 51.719 T 17-03-2017 IPR017814 Mycothiol biosynthesis protein, MshA GO:0008375|GO:0010125 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SHXM_RS26160 f14c3deebcb39ef1de82fdf3d9bd4356 443 Pfam PF13439 Glycosyltransferase Family 4 45 226 9.6E-31 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS26160 f14c3deebcb39ef1de82fdf3d9bd4356 443 TIGRFAM TIGR03449 mycothiol_MshA: D-inositol-3-phosphate glycosyltransferase 26 433 2.6E-201 T 17-03-2017 IPR017814 Mycothiol biosynthesis protein, MshA GO:0008375|GO:0010125 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SHXM_RS47675 9709c97a5f69a078ac70df4c94df0bb7 224 PIRSF PIRSF009467 1 224 2.1E-44 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS47675 9709c97a5f69a078ac70df4c94df0bb7 224 Hamap MF_01385 Urease accessory protein UreF [ureF]. 2 224 18.041 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS47675 9709c97a5f69a078ac70df4c94df0bb7 224 Pfam PF01730 UreF 34 173 6.1E-18 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS20170 12654288c58aacbc564a52c059cc840e 76 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 48 2.1E-16 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS20170 12654288c58aacbc564a52c059cc840e 76 Pfam PF09723 Zinc ribbon domain 1 40 4.8E-13 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS20170 12654288c58aacbc564a52c059cc840e 76 SMART SM00834 1 42 2.1E-15 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 SUPERFAMILY SSF90123 23 343 1.57E-60 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 Pfam PF00005 ABC transporter 377 526 2.1E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 Gene3D G3DSA:1.20.1560.10 31 339 1.8E-62 T 17-03-2017 SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 Pfam PF00664 ABC transporter transmembrane region 44 308 2.7E-41 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 ProSitePatterns PS00211 ABC transporters family signature. 498 512 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 Gene3D G3DSA:3.40.50.300 361 589 3.9E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 SMART SM00382 386 572 2.4E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS40775 7c863fbeba2f3469fd005d7fe1eb0ab6 615 SUPERFAMILY SSF52540 357 597 5.23E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19320 bbe165cf28b357070f919f23380e782f 142 Gene3D G3DSA:3.30.565.10 47 134 4.1E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19320 bbe165cf28b357070f919f23380e782f 142 Pfam PF13581 Histidine kinase-like ATPase domain 14 119 7.7E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19320 bbe165cf28b357070f919f23380e782f 142 SUPERFAMILY SSF55874 42 135 1.77E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS23850 52d7fc5705a1ba42de61af39b9e39032 229 SMART SM00382 28 215 4.4E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS23850 52d7fc5705a1ba42de61af39b9e39032 229 Pfam PF00005 ABC transporter 19 166 2.5E-34 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS23850 52d7fc5705a1ba42de61af39b9e39032 229 SUPERFAMILY SSF52540 1 221 3.69E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23850 52d7fc5705a1ba42de61af39b9e39032 229 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS23850 52d7fc5705a1ba42de61af39b9e39032 229 TIGRFAM TIGR02673 FtsE: cell division ATP-binding protein FtsE 1 215 3.9E-87 T 17-03-2017 IPR005286 Cell division protein FtsE, ATP-binding GO:0005524|GO:0051301 SHXM_RS23850 52d7fc5705a1ba42de61af39b9e39032 229 Gene3D G3DSA:3.40.50.300 1 221 8.3E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01025 4cd35cbdaee2318055cf8a52789ebbe2 507 Pfam PF00171 Aldehyde dehydrogenase family 32 493 3.2E-159 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS01025 4cd35cbdaee2318055cf8a52789ebbe2 507 Gene3D G3DSA:3.40.605.10 24 283 2.9E-91 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS01025 4cd35cbdaee2318055cf8a52789ebbe2 507 SUPERFAMILY SSF53720 21 497 1.44E-163 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS01025 4cd35cbdaee2318055cf8a52789ebbe2 507 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 269 276 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS01025 4cd35cbdaee2318055cf8a52789ebbe2 507 Gene3D G3DSA:3.40.309.10 284 469 4.7E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00097 Anthranilate synthase component II signature 102 110 2.4E-33 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00097 Anthranilate synthase component II signature 5 19 2.4E-33 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00097 Anthranilate synthase component II signature 167 180 2.4E-33 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00097 Anthranilate synthase component II signature 49 58 2.4E-33 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00097 Anthranilate synthase component II signature 77 88 2.4E-33 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00097 Anthranilate synthase component II signature 122 134 2.4E-33 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 SUPERFAMILY SSF52317 4 191 2.22E-56 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 Gene3D G3DSA:3.40.50.880 4 191 8.4E-65 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 Pfam PF00117 Glutamine amidotransferase class-I 7 190 6.7E-51 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 TIGRFAM TIGR00566 trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase 5 188 8.3E-60 T 17-03-2017 IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain GO:0008152 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 46 60 3.2E-9 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 77 93 3.2E-9 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00096 Glutamine amidotransferase superfamily signature 49 58 5.4E-13 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00096 Glutamine amidotransferase superfamily signature 167 180 5.4E-13 T 17-03-2017 SHXM_RS28230 7578873593dbe9be49357c2d24147b28 216 PRINTS PR00096 Glutamine amidotransferase superfamily signature 77 88 5.4E-13 T 17-03-2017 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 Pfam PF13191 AAA ATPase domain 232 364 1.7E-8 T 17-03-2017 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 PRINTS PR00364 Disease resistance protein signature 346 360 2.5E-6 T 17-03-2017 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 PRINTS PR00364 Disease resistance protein signature 437 451 2.5E-6 T 17-03-2017 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 PRINTS PR00364 Disease resistance protein signature 260 275 2.5E-6 T 17-03-2017 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SUPERFAMILY SSF48452 714 901 1.9E-18 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SMART SM00028 714 747 0.03 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SMART SM00028 834 867 13.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SMART SM00028 794 827 68.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SMART SM00028 874 907 12.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SMART SM00028 754 787 62.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SMART SM00382 257 403 3.7E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 SUPERFAMILY SSF52540 227 463 1.63E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 Gene3D G3DSA:1.25.40.10 676 898 5.4E-38 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 Gene3D G3DSA:1.25.40.10 947 996 5.4E-38 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 Gene3D G3DSA:3.40.50.300 235 395 2.6E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 Pfam PF13424 Tetratricopeptide repeat 755 824 1.7E-9 T 17-03-2017 SHXM_RS33230 f259c23f2df3b26aec24e6bcfedc9427 1095 Pfam PF13424 Tetratricopeptide repeat 676 745 1.5E-7 T 17-03-2017 SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 SUPERFAMILY SSF46785 351 409 9.43E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 Gene3D G3DSA:1.10.10.10 35 64 2.1E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 Gene3D G3DSA:1.10.10.10 355 414 4.8E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 Gene3D G3DSA:3.30.420.40 417 561 6.6E-45 T 17-03-2017 SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 SUPERFAMILY SSF53067 419 732 2.9E-42 T 17-03-2017 SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 Pfam PF00480 ROK family 429 728 8.9E-33 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 Pfam PF13551 Winged helix-turn helix 32 90 3.5E-15 T 17-03-2017 SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 Gene3D G3DSA:3.30.420.40 562 713 2.2E-24 T 17-03-2017 SHXM_RS42405 83b69a44ce444d44ed1413a9d6559f9f 748 SUPERFAMILY SSF46689 26 91 3.23E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08235 e2548357c83e4e7430a6ca900e116060 524 PIRSF PIRSF002741 9 522 7.1E-57 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS08235 e2548357c83e4e7430a6ca900e116060 524 SUPERFAMILY SSF53850 40 522 1.99E-91 T 17-03-2017 SHXM_RS08235 e2548357c83e4e7430a6ca900e116060 524 Gene3D G3DSA:3.40.190.10 148 290 1.2E-35 T 17-03-2017 SHXM_RS08235 e2548357c83e4e7430a6ca900e116060 524 Gene3D G3DSA:3.10.105.10 291 491 8.9E-34 T 17-03-2017 SHXM_RS08235 e2548357c83e4e7430a6ca900e116060 524 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 89 438 6.0E-65 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 Gene3D G3DSA:3.40.50.2300 176 307 7.7E-46 T 17-03-2017 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 SUPERFAMILY SSF47413 2 61 3.18E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 Gene3D G3DSA:1.10.260.40 4 55 5.3E-25 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 1.9E-17 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 Gene3D G3DSA:3.40.50.2300 56 175 3.4E-36 T 17-03-2017 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 SMART SM00354 3 73 1.6E-29 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 Pfam PF13377 Periplasmic binding protein-like domain 170 328 1.4E-35 T 17-03-2017 SHXM_RS04530 dd607da8633feb9b302ef13b7b793a0c 335 SUPERFAMILY SSF53822 62 332 4.08E-67 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 Gene3D G3DSA:1.10.10.10 6 57 9.7E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 Gene3D G3DSA:3.40.50.1360 74 208 6.0E-10 T 17-03-2017 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 Pfam PF00455 DeoR C terminal sensor domain 73 228 1.3E-45 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 SMART SM01134 70 230 5.9E-64 T 17-03-2017 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 SUPERFAMILY SSF100950 73 229 6.28E-29 T 17-03-2017 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 5.7E-18 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 SMART SM00420 6 58 8.0E-19 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 SMART SM00345 2 59 1.2E-4 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 1.3E-10 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 1.3E-10 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS46985 b97bd7d23dd2f606cbc30b87751d4804 249 SUPERFAMILY SSF46785 4 58 3.12E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44135 af95f7ddf23c2a7438ca1a44b70812db 127 SUPERFAMILY SSF54593 1 121 8.17E-16 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS44135 af95f7ddf23c2a7438ca1a44b70812db 127 Gene3D G3DSA:3.10.180.10 4 122 6.6E-13 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 SMART SM00420 14 66 2.6E-12 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 Gene3D G3DSA:1.10.10.10 14 64 2.3E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 Pfam PF08220 DeoR-like helix-turn-helix domain 14 65 6.8E-13 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 ProSitePatterns PS00894 DeoR-type HTH domain signature. 14 48 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 SUPERFAMILY SSF100950 83 236 2.83E-18 T 17-03-2017 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 Gene3D G3DSA:3.40.50.1360 84 223 6.5E-5 T 17-03-2017 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 SMART SM01134 81 241 2.5E-42 T 17-03-2017 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 SUPERFAMILY SSF46785 12 72 2.63E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 46 64 1.6E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 32 46 1.6E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS41590 dc1d0f8b99d36dd664cde2d89f93f45d 262 Pfam PF00455 DeoR C terminal sensor domain 83 236 2.1E-35 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS42815 d346c80beed4a71a36a125d2097fef63 218 Gene3D G3DSA:3.40.50.150 7 218 2.3E-71 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS42815 d346c80beed4a71a36a125d2097fef63 218 Pfam PF01596 O-methyltransferase 21 217 2.3E-65 T 17-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 SHXM_RS42815 d346c80beed4a71a36a125d2097fef63 218 SUPERFAMILY SSF53335 8 218 7.8E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 Pfam PF01883 Domain of unknown function DUF59 11 84 3.3E-18 T 17-03-2017 IPR002744 Domain of unknown function DUF59 SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 Gene3D G3DSA:3.40.50.300 108 363 1.6E-88 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 SUPERFAMILY SSF52540 118 367 2.73E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 ProSitePatterns PS01215 Mrp family signature. 222 238 - T 17-03-2017 IPR000808 Mrp, conserved site GO:0005524 SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 Pfam PF10609 NUBPL iron-transfer P-loop NTPase 118 364 3.3E-91 T 17-03-2017 IPR019591 Mrp/NBP35 ATP-binding protein SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 Hamap MF_02040 Iron-sulfur cluster carrier protein. 109 365 34.816 T 17-03-2017 IPR019591 Mrp/NBP35 ATP-binding protein SHXM_RS34125 8a74656b5cecc1a0fed26fdb9ead9dc6 384 SUPERFAMILY SSF117916 9 93 1.37E-23 T 17-03-2017 SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 Gene3D G3DSA:3.40.47.10 1 252 2.7E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 Gene3D G3DSA:3.40.47.10 256 401 2.5E-53 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 154 170 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 SUPERFAMILY SSF53901 209 399 1.33E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 SUPERFAMILY SSF53901 3 244 4.19E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 SMART SM00825 Beta-ketoacyl synthase 5 401 1.2E-17 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3 239 3.6E-39 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS02145 b789879177c3e7f5052582ddad29cfe2 402 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 247 357 4.0E-33 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS14355 9b2d225ae5d0e94d497ed7d43f672357 123 SUPERFAMILY SSF54427 1 117 7.32E-33 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS14355 9b2d225ae5d0e94d497ed7d43f672357 123 Gene3D G3DSA:3.10.450.50 5 119 5.2E-15 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS14355 9b2d225ae5d0e94d497ed7d43f672357 123 Pfam PF12680 SnoaL-like domain 8 111 3.1E-12 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 Pfam PF12833 Helix-turn-helix domain 238 316 2.8E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 Gene3D G3DSA:3.40.50.880 4 221 1.4E-43 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 SMART SM00342 232 315 1.2E-28 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 Gene3D G3DSA:1.10.10.60 270 321 1.3E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 Gene3D G3DSA:1.10.10.60 222 269 8.4E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 SUPERFAMILY SSF52317 1 198 1.11E-39 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 SUPERFAMILY SSF46689 269 319 3.08E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 269 311 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 Pfam PF01965 DJ-1/PfpI family 75 177 1.1E-9 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS37950 2664a0ccedc587fe1d62b50fdb739570 328 SUPERFAMILY SSF46689 217 266 8.78E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 356 766 2.0E-121 T 17-03-2017 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 Pfam PF14579 Helix-hairpin-helix motif 840 947 9.9E-19 T 17-03-2017 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 Pfam PF02811 PHP domain 6 123 3.1E-14 T 17-03-2017 IPR004013 PHP domain GO:0003824 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 SUPERFAMILY SSF89550 5 72 5.69E-8 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 SMART SM00481 5 72 6.9E-19 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 Gene3D G3DSA:3.20.20.140 6 72 1.2E-8 T 17-03-2017 SHXM_RS16875 98d023dd9f4083599a73ab406625767b 1207 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 4 1073 9.6E-156 T 17-03-2017 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 SUPERFAMILY SSF56176 9 190 2.29E-48 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 ProSitePatterns PS00862 Oxygen oxidoreductases covalent FAD-binding site. 25 58 - T 17-03-2017 IPR006093 Oxygen oxidoreductase covalent FAD-binding site GO:0016491|GO:0055114 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 TIGRFAM TIGR01679 bact_FAD_ox: FAD-linked oxidoreductase 14 440 2.1E-123 T 17-03-2017 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 Pfam PF01565 FAD binding domain 29 160 1.8E-31 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 Pfam PF04030 D-arabinono-1,4-lactone oxidase 184 438 5.5E-79 T 17-03-2017 IPR007173 D-arabinono-1,4-lactone oxidase GO:0003885|GO:0016020|GO:0055114 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 Gene3D G3DSA:3.30.43.10 10 82 1.2E-23 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 Gene3D G3DSA:3.30.465.10 83 190 2.3E-29 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS37580 78d890963ae1428c0832b1bd082e9caf 441 PIRSF PIRSF000136 3 441 8.2E-118 T 17-03-2017 IPR010031 L-gulonolactone/D-arabinono-1,4-lactone oxidase GO:0016899|GO:0055114 SHXM_RS32955 fc28540aaa042eea490146ad4105b5d0 120 Gene3D G3DSA:3.30.70.900 1 97 1.4E-25 T 17-03-2017 SHXM_RS32955 fc28540aaa042eea490146ad4105b5d0 120 Pfam PF07045 Domain of unknown function (DUF1330) 4 97 1.2E-21 T 17-03-2017 IPR010753 Domain of unknown function DUF1330 SHXM_RS32955 fc28540aaa042eea490146ad4105b5d0 120 SUPERFAMILY SSF54909 1 97 2.47E-20 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS02590 e10d0b1659269d36dfa1432b3926dcee 318 Gene3D G3DSA:3.40.50.720 4 262 9.3E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02590 e10d0b1659269d36dfa1432b3926dcee 318 SUPERFAMILY SSF51735 1 300 8.3E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02590 e10d0b1659269d36dfa1432b3926dcee 318 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 218 8.8E-20 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 SUPERFAMILY SSF52402 150 290 3.68E-17 T 17-03-2017 SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 PRINTS PR01438 Universal stress protein signature 114 136 7.3E-9 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 PRINTS PR01438 Universal stress protein signature 96 108 7.3E-9 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 PRINTS PR01438 Universal stress protein signature 2 20 7.3E-9 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 Pfam PF00582 Universal stress protein family 150 289 1.1E-12 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 Pfam PF00582 Universal stress protein family 1 136 2.8E-20 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 Gene3D G3DSA:3.40.50.620 1 131 6.5E-29 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 Gene3D G3DSA:3.40.50.620 132 289 2.5E-21 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43510 923bb11febaefb1f1768059486a3cc00 291 SUPERFAMILY SSF52402 4 139 2.85E-24 T 17-03-2017 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 Pfam PF13377 Periplasmic binding protein-like domain 171 330 1.3E-34 T 17-03-2017 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 3 13 2.6E-6 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 13 23 2.6E-6 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 Gene3D G3DSA:3.40.50.2300 176 313 2.5E-46 T 17-03-2017 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 Gene3D G3DSA:1.10.260.40 3 53 1.1E-27 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 SUPERFAMILY SSF47413 2 59 5.63E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 SMART SM00354 1 71 2.7E-36 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 Gene3D G3DSA:3.40.50.2300 54 175 4.8E-43 T 17-03-2017 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 ProSitePatterns PS00356 LacI-type HTH domain signature. 4 22 - T 17-03-2017 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 48 4.5E-21 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22325 f4b0e4ece277e1b0cb2aa1431a0d14a2 338 SUPERFAMILY SSF53822 60 333 1.18E-75 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 Pfam PF00106 short chain dehydrogenase 9 185 9.6E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 182 1.8E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 1.8E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 144 163 1.8E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.8E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 118 134 1.8E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 SUPERFAMILY SSF51735 5 228 4.5E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 Gene3D G3DSA:3.40.50.720 6 215 2.6E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16380 4d7d953535da5b664b3fe47de7f6341a 260 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 131 159 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS43170 fb00f43066ffab9528c4763b10326569 325 Gene3D G3DSA:3.30.420.40 5 140 1.4E-35 T 17-03-2017 SHXM_RS43170 fb00f43066ffab9528c4763b10326569 325 SUPERFAMILY SSF53067 6 308 1.43E-59 T 17-03-2017 SHXM_RS43170 fb00f43066ffab9528c4763b10326569 325 Gene3D G3DSA:3.30.420.40 141 291 3.1E-47 T 17-03-2017 SHXM_RS43170 fb00f43066ffab9528c4763b10326569 325 ProSitePatterns PS01125 ROK family signature. 138 165 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS43170 fb00f43066ffab9528c4763b10326569 325 Pfam PF00480 ROK family 7 307 1.5E-59 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS40615 3b21de861ed7ec3ce01990316ecdc88b 509 Pfam PF00171 Aldehyde dehydrogenase family 30 489 2.6E-132 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS40615 3b21de861ed7ec3ce01990316ecdc88b 509 SUPERFAMILY SSF53720 28 497 2.09E-135 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS40615 3b21de861ed7ec3ce01990316ecdc88b 509 Gene3D G3DSA:3.40.605.10 29 277 2.2E-75 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS40615 3b21de861ed7ec3ce01990316ecdc88b 509 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 262 269 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS40615 3b21de861ed7ec3ce01990316ecdc88b 509 Gene3D G3DSA:3.40.309.10 278 457 5.2E-55 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 PIRSF PIRSF001134 1 358 1.2E-135 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 SUPERFAMILY SSF50494 174 353 1.07E-37 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 Gene3D G3DSA:2.40.10.10 257 345 3.2E-30 T 17-03-2017 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 Pfam PF00089 Trypsin 198 349 1.4E-11 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 Gene3D G3DSA:2.40.10.10 172 256 6.7E-32 T 17-03-2017 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 Gene3D G3DSA:3.30.300.50 47 98 1.4E-6 T 17-03-2017 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 308 319 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 Pfam PF02983 Alpha-lytic protease prodomain 100 154 5.7E-17 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 Gene3D G3DSA:3.30.300.50 99 167 9.4E-13 T 17-03-2017 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 323 337 1.6E-46 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 259 279 1.6E-46 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 280 297 1.6E-46 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 198 212 1.6E-46 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16890 db1e53ba891d4d5f53fcff30646b1b4d 358 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 299 322 1.6E-46 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 SMART SM00448 16 135 6.1E-20 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 SUPERFAMILY SSF46894 160 228 1.77E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 Gene3D G3DSA:1.10.10.10 171 227 1.7E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 Pfam PF00072 Response regulator receiver domain 18 135 2.5E-20 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 185 4.1E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 201 4.1E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 201 213 4.1E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 Pfam PF00196 Bacterial regulatory proteins, luxR family 170 225 9.5E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 ProSitePatterns PS00622 LuxR-type HTH domain signature. 185 212 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 SUPERFAMILY SSF52172 15 148 2.99E-26 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 Gene3D G3DSA:3.40.50.2300 15 170 4.9E-33 T 17-03-2017 SHXM_RS43320 cb995ccd6d552e0362b690e964f7fa52 235 SMART SM00421 168 225 1.6E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Gene3D G3DSA:1.20.140.10 233 317 1.2E-22 T 17-03-2017 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Gene3D G3DSA:1.20.140.10 369 456 1.2E-22 T 17-03-2017 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Gene3D G3DSA:2.40.110.10 134 232 5.5E-31 T 17-03-2017 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 371 451 4.4E-12 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 244 322 6.6E-6 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Gene3D G3DSA:1.10.540.10 2 131 4.7E-20 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 135 230 1.2E-21 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 131 3.6E-15 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 SUPERFAMILY SSF47203 371 452 5.15E-16 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 SUPERFAMILY SSF47203 244 318 5.15E-16 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31660 3c3eaae092f049ce2a6bfcffc1b6e087 459 SUPERFAMILY SSF56645 2 254 3.4E-59 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 SUPERFAMILY SSF53067 4 235 4.21E-35 T 17-03-2017 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 SUPERFAMILY SSF53067 237 467 5.74E-33 T 17-03-2017 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 Gene3D G3DSA:3.30.420.40 3 232 3.4E-35 T 17-03-2017 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 Gene3D G3DSA:3.30.420.40 238 463 1.0E-23 T 17-03-2017 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 335 356 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 PIRSF PIRSF000538 1 473 6.0E-66 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 242 423 8.5E-18 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS20595 b57ddb69881e7e802fb992e6f3ef62ed 528 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 4 231 4.9E-34 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 Pfam PF00356 Bacterial regulatory proteins, lacI family 6 47 4.1E-11 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 Gene3D G3DSA:3.40.50.2300 165 322 1.5E-25 T 17-03-2017 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 Gene3D G3DSA:1.10.260.40 4 47 8.0E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 SUPERFAMILY SSF53822 74 315 1.91E-30 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 SMART SM00354 3 65 9.2E-7 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 ProSitePatterns PS00356 LacI-type HTH domain signature. 6 24 - T 17-03-2017 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 SUPERFAMILY SSF47413 3 56 2.44E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 Gene3D G3DSA:3.40.50.2300 74 164 2.1E-8 T 17-03-2017 SHXM_RS19460 15779784be513ed842b9392b8c12bee4 336 Pfam PF13377 Periplasmic binding protein-like domain 165 321 1.4E-22 T 17-03-2017 SHXM_RS21435 4dbb6a089ddc25e5f83c6dd6a1f26b73 434 SMART SM00530 85 142 7.2 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS21435 4dbb6a089ddc25e5f83c6dd6a1f26b73 434 SMART SM00530 12 75 1.7E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS21435 4dbb6a089ddc25e5f83c6dd6a1f26b73 434 Gene3D G3DSA:1.10.260.40 28 78 1.1E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS21435 4dbb6a089ddc25e5f83c6dd6a1f26b73 434 Gene3D G3DSA:1.10.260.40 87 142 2.4E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS21435 4dbb6a089ddc25e5f83c6dd6a1f26b73 434 Pfam PF01381 Helix-turn-helix 28 73 7.4E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS21435 4dbb6a089ddc25e5f83c6dd6a1f26b73 434 SUPERFAMILY SSF47413 28 85 5.63E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 Gene3D G3DSA:3.40.50.2300 173 339 1.6E-48 T 17-03-2017 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 SMART SM00354 3 74 6.7E-27 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 Gene3D G3DSA:1.10.260.40 4 63 1.6E-23 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 SUPERFAMILY SSF53822 64 338 1.37E-60 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 Pfam PF13377 Periplasmic binding protein-like domain 171 337 1.5E-29 T 17-03-2017 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 SUPERFAMILY SSF47413 3 62 1.13E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 51 7.5E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS30135 72418f72c77cb3bfaf3447dbb284da20 340 Gene3D G3DSA:3.40.50.2300 64 172 5.7E-34 T 17-03-2017 SHXM_RS03115 77e26185588401c5138dbc4f10f68ce5 368 Pfam PF01032 FecCD transport family 58 138 3.4E-20 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS03115 77e26185588401c5138dbc4f10f68ce5 368 Gene3D G3DSA:1.10.3470.10 47 139 4.6E-22 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS03115 77e26185588401c5138dbc4f10f68ce5 368 SUPERFAMILY SSF81345 39 139 8.76E-19 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS02695 62112e33dbf5c35975d7da74f9395c2f 263 SUPERFAMILY SSF53335 62 196 4.1E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02695 62112e33dbf5c35975d7da74f9395c2f 263 Gene3D G3DSA:3.40.50.150 62 237 9.3E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02695 62112e33dbf5c35975d7da74f9395c2f 263 Pfam PF08241 Methyltransferase domain 68 164 2.7E-15 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 Gene3D G3DSA:2.60.40.10 61 144 1.6E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 Gene3D G3DSA:2.60.120.260 177 266 2.4E-4 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 SUPERFAMILY SSF48208 632 1027 4.93E-45 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 SUPERFAMILY SSF49785 288 410 1.98E-5 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 Gene3D G3DSA:2.60.120.260 514 626 1.6E-18 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 347 515 1.6E-62 T 17-03-2017 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 SUPERFAMILY SSF49785 137 265 5.78E-6 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS11395 366c862abadf16546ab9cf843f735bc7 1067 Pfam PF05592 Bacterial alpha-L-rhamnosidase 525 1024 2.8E-188 T 17-03-2017 IPR008902 Bacterial alpha-L-rhamnosidase SHXM_RS47250 973f45140f98b91affa8edad39130635 648 Gene3D G3DSA:2.60.120.260 66 158 8.9E-6 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS47250 973f45140f98b91affa8edad39130635 648 SUPERFAMILY SSF48208 212 622 4.22E-19 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 192 260 5.6E-13 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 SUPERFAMILY SSF51735 11 187 1.4E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 Hamap MF_02129 L-carnitine dehydrogenase [lcdH]. 12 326 50.734 T 17-03-2017 IPR026578 L-carnitine dehydrogenase KEGG: 00040+1.1.1.10|MetaCyc: PWY-3602|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-7472 SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 Gene3D G3DSA:3.40.50.720 8 193 1.7E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 Gene3D G3DSA:1.10.1040.10 194 264 2.0E-7 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 14 186 2.6E-43 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS32030 a0732e799c2676eecc041bfe568b642d 337 SUPERFAMILY SSF48179 192 277 1.28E-11 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 SMART SM00357 3 67 3.1E-28 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 PRINTS PR00050 Cold shock protein signature 4 19 1.2E-15 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 PRINTS PR00050 Cold shock protein signature 25 34 1.2E-15 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 PRINTS PR00050 Cold shock protein signature 40 58 1.2E-15 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 66 1.2E-27 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 PIRSF PIRSF002599 1 67 5.6E-24 T 17-03-2017 IPR012156 Cold shock, CspA GO:0003676 SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 Gene3D G3DSA:2.40.50.140 1 65 1.5E-28 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 SUPERFAMILY SSF50249 1 66 2.94E-23 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS39920 1cb25493cb5197df35aeb914d43d0457 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 SMART SM00062 64 288 1.3E-53 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 65 282 6.8E-45 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 Gene3D G3DSA:3.40.190.10 145 246 3.4E-22 T 17-03-2017 SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 SUPERFAMILY SSF53850 54 282 7.67E-52 T 17-03-2017 SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 SUPERFAMILY SSF53850 7 24 7.67E-52 T 17-03-2017 SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 Gene3D G3DSA:3.40.190.10 61 144 9.3E-22 T 17-03-2017 SHXM_RS14940 424ec76eab52f47e7fce97f725e407e4 304 Gene3D G3DSA:3.40.190.10 247 282 9.3E-22 T 17-03-2017 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:3.40.47.10 38 298 1.9E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF08659 KR domain 1235 1415 2.2E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 286 5.0E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SMART SM00823 Phosphopantetheine attachment site 1523 1595 1.9E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SMART SM01294 1524 1591 5.3E-6 T 17-03-2017 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF52151 574 700 9.94E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF52151 765 860 9.94E-64 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:3.40.50.720 1235 1419 2.9E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF47336 1515 1599 1.19E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 411 3.6E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF51735 1073 1222 2.87E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF51735 983 1039 2.87E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:3.40.366.10 574 694 8.3E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:3.40.366.10 764 873 8.3E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:3.40.47.10 300 464 1.7E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF53901 32 409 5.03E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:3.30.70.250 699 763 2.9E-9 T 17-03-2017 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1550 1565 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF00698 Acyl transferase domain 575 892 1.2E-89 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF51735 1232 1450 5.54E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SMART SM00825 Beta-ketoacyl synthase 38 464 6.4E-211 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Gene3D G3DSA:1.10.1200.10 1520 1595 6.1E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF00550 Phosphopantetheine attachment site 1530 1591 2.6E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1235 1417 2.4E-57 T 17-03-2017 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF08990 Erythronolide synthase docking 5 27 1.3E-8 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 416 538 5.8E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SUPERFAMILY SSF55048 699 764 9.16E-15 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07235 24171e1b691e302450c4169a620c41f1 1652 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 577 873 7.3E-114 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS40305 031c3edfebcc3ba66fb2a2e12c9d35b3 400 Gene3D G3DSA:3.30.565.10 306 391 1.1E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40305 031c3edfebcc3ba66fb2a2e12c9d35b3 400 Pfam PF07730 Histidine kinase 183 251 1.5E-13 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS40305 031c3edfebcc3ba66fb2a2e12c9d35b3 400 SUPERFAMILY SSF55874 269 390 3.59E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 TIGRFAM TIGR02386 rpoC_TIGR: DNA-directed RNA polymerase, beta' subunit 10 1256 0.0 T 17-03-2017 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 SMART SM00663 310 589 9.2E-174 T 17-03-2017 IPR006592 RNA polymerase, N-terminal GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Pfam PF04997 RNA polymerase Rpb1, domain 1 7 417 4.7E-82 T 17-03-2017 IPR007080 RNA polymerase Rpb1, domain 1 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Pfam PF00623 RNA polymerase Rpb1, domain 2 419 480 1.3E-8 T 17-03-2017 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Pfam PF00623 RNA polymerase Rpb1, domain 2 468 560 9.6E-28 T 17-03-2017 IPR000722 RNA polymerase, alpha subunit GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Gene3D G3DSA:2.40.40.20 424 451 3.7E-38 T 17-03-2017 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Gene3D G3DSA:2.40.40.20 492 564 3.7E-38 T 17-03-2017 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Pfam PF05000 RNA polymerase Rpb1, domain 4 765 829 7.5E-14 T 17-03-2017 IPR007083 RNA polymerase Rpb1, domain 4 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 SUPERFAMILY SSF64484 5 1256 0.0 T 17-03-2017 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Gene3D G3DSA:2.40.50.100 1046 1100 4.0E-7 T 17-03-2017 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Pfam PF04998 RNA polymerase Rpb1, domain 5 843 1204 2.4E-67 T 17-03-2017 IPR007081 RNA polymerase Rpb1, domain 5 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Hamap MF_01322 DNA-directed RNA polymerase subunit beta' [rpoC]. 5 1265 9.991 T 17-03-2017 IPR012754 DNA-directed RNA polymerase, subunit beta-prime GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31120 e56051ec9ad2724fb6c50a630e118178 1304 Pfam PF04983 RNA polymerase Rpb1, domain 3 564 736 1.8E-21 T 17-03-2017 IPR007066 RNA polymerase Rpb1, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS39805 6bf6d857ed32861e89d363661aea9926 134 SUPERFAMILY SSF54909 1 97 1.61E-13 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS39805 6bf6d857ed32861e89d363661aea9926 134 SMART SM00886 2 93 8.8E-12 T 17-03-2017 IPR013097 Stress responsive alpha-beta barrel SHXM_RS39805 6bf6d857ed32861e89d363661aea9926 134 Gene3D G3DSA:3.30.70.900 1 90 1.5E-11 T 17-03-2017 SHXM_RS39805 6bf6d857ed32861e89d363661aea9926 134 Pfam PF07876 Stress responsive A/B Barrel Domain 2 92 4.0E-13 T 17-03-2017 IPR013097 Stress responsive alpha-beta barrel SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 Gene3D G3DSA:1.20.120.530 83 221 8.1E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 Gene3D G3DSA:1.10.10.10 9 77 1.2E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 SMART SM00895 88 213 4.2E-21 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 Pfam PF00392 Bacterial regulatory proteins, gntR family 16 77 4.7E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 Pfam PF07729 FCD domain 89 212 5.2E-24 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 SMART SM00345 20 78 2.1E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 SUPERFAMILY SSF46785 13 107 2.73E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41765 40c425fe8b9e87660d9a2f391df87e0f 222 SUPERFAMILY SSF48008 85 221 1.33E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 Gene3D G3DSA:1.10.10.10 126 209 7.7E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 Pfam PF00072 Response regulator receiver domain 8 119 1.5E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 SMART SM00448 6 119 5.3E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 Pfam PF00196 Bacterial regulatory proteins, luxR family 148 203 6.4E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 Gene3D G3DSA:3.40.50.2300 2 125 1.3E-35 T 17-03-2017 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 SUPERFAMILY SSF52172 5 136 5.41E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 ProSitePatterns PS00622 LuxR-type HTH domain signature. 163 190 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 SUPERFAMILY SSF46894 139 209 2.75E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 SMART SM00421 146 203 1.5E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 163 179 2.9E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 149 163 2.9E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28890 381afdf417adcc49931bd5e53b731d36 212 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 179 191 2.9E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 SUPERFAMILY SSF46785 5 77 1.78E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 Pfam PF09339 IclR helix-turn-helix domain 7 57 4.4E-16 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 Pfam PF01614 Bacterial transcriptional regulator 125 248 1.5E-25 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 Gene3D G3DSA:3.30.450.40 75 252 2.5E-40 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 Gene3D G3DSA:1.10.10.10 3 74 2.3E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 SUPERFAMILY SSF55781 71 251 7.19E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS03985 791c9fe36afb6ba054d54ba635b387bb 255 SMART SM00346 5 95 4.8E-27 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS05110 c33c475e804dac9569ee05b2d7cbc0f2 230 SUPERFAMILY SSF51197 13 214 1.51E-42 T 17-03-2017 SHXM_RS05110 c33c475e804dac9569ee05b2d7cbc0f2 230 Pfam PF13532 2OG-Fe(II) oxygenase superfamily 15 213 6.7E-49 T 17-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like SHXM_RS05110 c33c475e804dac9569ee05b2d7cbc0f2 230 Gene3D G3DSA:2.60.120.590 11 213 1.2E-48 T 17-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like SHXM_RS14725 007221fae84aa5dad5d959ad3170a46b 955 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 3 33 5.6E-4 T 17-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SHXM_RS14725 007221fae84aa5dad5d959ad3170a46b 955 Gene3D G3DSA:1.50.10.10 421 624 8.0E-12 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS14725 007221fae84aa5dad5d959ad3170a46b 955 SUPERFAMILY SSF48208 259 701 2.3E-46 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 SUPERFAMILY SSF47005 135 178 6.41E-11 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 Gene3D G3DSA:4.10.320.10 140 187 3.3E-17 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 Pfam PF00364 Biotin-requiring enzyme 6 77 2.6E-16 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 Gene3D G3DSA:2.40.50.100 5 93 6.6E-24 T 17-03-2017 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 SUPERFAMILY SSF52777 197 433 2.62E-72 T 17-03-2017 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 SUPERFAMILY SSF51230 4 97 2.09E-24 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 Pfam PF02817 e3 binding domain 141 175 3.5E-13 T 17-03-2017 IPR004167 E3-binding domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 208 433 2.8E-72 T 17-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS28380 203e3fef04e0a11906f3422451e9186e 436 Gene3D G3DSA:3.30.559.10 198 433 4.3E-77 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS25390 8a57dbe53a4d1ebbf05a03504196db93 439 Pfam PF04024 PspC domain 24 77 4.6E-15 T 17-03-2017 IPR007168 Phage shock protein, PspC, N-terminal SHXM_RS10955 716b3b5b0f055a13034af028433c0b3a 318 Pfam PF00294 pfkB family carbohydrate kinase 8 302 4.4E-49 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS10955 716b3b5b0f055a13034af028433c0b3a 318 SUPERFAMILY SSF53613 5 305 1.11E-63 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS10955 716b3b5b0f055a13034af028433c0b3a 318 Gene3D G3DSA:3.40.1190.20 1 308 2.9E-66 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 Pfam PF00704 Glycosyl hydrolases family 18 236 358 4.5E-7 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 SUPERFAMILY SSF50370 39 161 7.47E-42 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 SMART SM00458 39 163 8.6E-35 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 Gene3D G3DSA:2.80.10.50 37 161 1.3E-44 T 17-03-2017 SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 Pfam PF00652 Ricin-type beta-trefoil lectin domain 39 160 4.6E-32 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 SUPERFAMILY SSF51445 180 435 3.95E-20 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS41685 1ac8eaa381e66db56b9ab9be83a5f28d 462 Gene3D G3DSA:3.20.20.80 232 434 2.4E-14 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 Gene3D G3DSA:3.30.350.10 41 147 3.6E-35 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 ProSitePatterns PS00999 Streptomyces subtilisin-type inhibitors signature. 67 85 - T 17-03-2017 IPR020054 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor, conserved site GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 PRINTS PR00294 Streptomyces subtilisin inhibitor signature 105 121 4.6E-27 T 17-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 PRINTS PR00294 Streptomyces subtilisin inhibitor signature 122 138 4.6E-27 T 17-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 PRINTS PR00294 Streptomyces subtilisin inhibitor signature 41 67 4.6E-27 T 17-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 Pfam PF00720 Subtilisin inhibitor-like 41 133 1.1E-37 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 Hamap MF_00778 Probable subtilase-type protease inhibitor [sti]. 39 147 31.846 T 17-03-2017 IPR000691 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 SUPERFAMILY SSF55399 39 147 4.71E-39 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS16885 78076bc8dcc75193dd234b12171df031 147 ProDom PD004028 INHIBITOR PROTEASE SERINE DIRECT SEQUENCING SUBTILISIN PRECURSOR SIGNAL INHIBITOR-LIKE INHIBITOR 44 135 8.0E-42 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS32755 27d80b8c72923534075f67ad6f15be8b 377 SUPERFAMILY SSF55347 141 311 1.08E-18 T 17-03-2017 SHXM_RS32755 27d80b8c72923534075f67ad6f15be8b 377 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 12 134 2.4E-19 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS32755 27d80b8c72923534075f67ad6f15be8b 377 Gene3D G3DSA:3.30.360.10 149 370 2.1E-22 T 17-03-2017 SHXM_RS32755 27d80b8c72923534075f67ad6f15be8b 377 SUPERFAMILY SSF51735 9 185 2.77E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32755 27d80b8c72923534075f67ad6f15be8b 377 Gene3D G3DSA:3.40.50.720 8 148 3.4E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 Gene3D G3DSA:3.90.1260.10 174 395 2.2E-81 T 17-03-2017 IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain body GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 TIGRFAM TIGR00032 argG: argininosuccinate synthase 4 392 4.5E-145 T 17-03-2017 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 Hamap MF_00005 Argininosuccinate synthase [argG]. 2 396 51.504 T 17-03-2017 IPR023434 Argininosuccinate synthase, type 1 subfamily GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 ProSitePatterns PS00564 Argininosuccinate synthase signature 1. 8 16 - T 17-03-2017 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 Pfam PF00764 Arginosuccinate synthase 6 391 7.2E-183 T 17-03-2017 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 ProSitePatterns PS00565 Argininosuccinate synthase signature 2. 117 128 - T 17-03-2017 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 Gene3D G3DSA:3.40.50.620 3 173 9.9E-55 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 SUPERFAMILY SSF52402 3 166 1.3E-41 T 17-03-2017 SHXM_RS12875 93ea1a7d8d4266203a589bd99d66fbad 398 SUPERFAMILY SSF69864 171 395 8.76E-84 T 17-03-2017 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Gene3D G3DSA:3.40.47.10 311 476 8.1E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SUPERFAMILY SSF52151 772 868 6.54E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SUPERFAMILY SSF52151 581 708 6.54E-74 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Gene3D G3DSA:3.40.47.10 60 310 9.4E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 211 227 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SUPERFAMILY SSF55048 707 771 2.88E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Gene3D G3DSA:3.30.70.250 706 770 1.4E-10 T 17-03-2017 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Gene3D G3DSA:3.40.366.10 577 702 2.8E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Gene3D G3DSA:3.40.366.10 771 881 2.8E-78 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SUPERFAMILY SSF53901 54 421 5.56E-98 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Pfam PF00698 Acyl transferase domain 584 897 4.5E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Gene3D G3DSA:1.10.1200.10 2 40 2.9E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 306 423 2.4E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 426 548 2.3E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SMART SM00825 Beta-ketoacyl synthase 60 476 4.2E-205 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 584 880 2.7E-118 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SMART SM00826 948 1113 2.8E-74 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Pfam PF14765 Polyketide synthase dehydratase 948 1151 4.5E-45 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 SUPERFAMILY SSF47336 1 73 8.49E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS16715 78b43c0971fc95ee9f599939a21d8a6c 1151 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 58 298 7.5E-84 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS04940 58ec1c179c1c9b3ae209fe100fad2769 145 SUPERFAMILY SSF50475 13 144 1.14E-16 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS04940 58ec1c179c1c9b3ae209fe100fad2769 145 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 13 87 8.5E-6 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS04940 58ec1c179c1c9b3ae209fe100fad2769 145 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 13 144 5.7E-25 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS04940 58ec1c179c1c9b3ae209fe100fad2769 145 Gene3D G3DSA:2.30.110.10 13 144 2.1E-10 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 SUPERFAMILY SSF55781 73 252 4.38E-44 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 SUPERFAMILY SSF46785 10 80 1.31E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 Gene3D G3DSA:3.30.450.40 77 253 1.4E-46 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 SMART SM00346 10 96 5.7E-17 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 Pfam PF09339 IclR helix-turn-helix domain 10 56 5.7E-12 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 Pfam PF01614 Bacterial transcriptional regulator 126 248 1.6E-21 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS01080 c38c67ef4ba600970691b4f16dede3e4 263 Gene3D G3DSA:1.10.10.10 9 76 5.7E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43340 a81021999fa720523d30068f1226e0fa 264 SUPERFAMILY SSF53681 106 221 3.71E-18 T 17-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS43340 a81021999fa720523d30068f1226e0fa 264 Pfam PF01177 Asp/Glu/Hydantoin racemase 28 194 5.1E-12 T 17-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS43340 a81021999fa720523d30068f1226e0fa 264 ProSitePatterns PS00923 Aspartate and glutamate racemases signature 1. 67 75 - T 17-03-2017 IPR018187 Asp/Glu racemase, active site 1 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS43340 a81021999fa720523d30068f1226e0fa 264 SUPERFAMILY SSF53681 2 102 2.29E-21 T 17-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS43340 a81021999fa720523d30068f1226e0fa 264 Gene3D G3DSA:3.40.50.1860 2 156 1.1E-33 T 17-03-2017 IPR001920 Asp/Glu racemase GO:0008152|GO:0016855 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 Pfam PF14508 Glycosyl-hydrolase 97 N-terminal 42 284 5.9E-42 T 17-03-2017 IPR029486 Glycosyl-hydrolase 97, N-terminal domain SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 SMART SM00776 748 893 1.6E-49 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 Gene3D G3DSA:3.20.20.70 316 424 1.3E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 SUPERFAMILY SSF49785 750 894 2.25E-38 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 Pfam PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation 520 613 3.6E-14 T 17-03-2017 IPR029483 Glycosyl-hydrolase 97, C-terminal oligomerisation domain SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 Pfam PF08305 NPCBM/NEW2 domain 751 891 1.5E-45 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 Pfam PF10566 Glycoside hydrolase 97 289 518 2.1E-56 T 17-03-2017 IPR019563 Glycosyl-hydrolase 97, catalytic domain SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 648 725 2.9E-6 T 17-03-2017 IPR018905 Alpha-galactosidase, NEW3 domain SHXM_RS48060 944b69348a2cea856b043c2665c8e455 895 SUPERFAMILY SSF51445 310 470 3.41E-16 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 ProDom PD001367 RIBOSOMAL RIBONUCLEOPROTEIN L11 RRNA-BINDING RNA-BINDING METHYLATION 50S L11 BACTERIAL CHLOROPLAST 39 76 2.0E-16 T 17-03-2017 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 ProSitePatterns PS00359 Ribosomal protein L11 signature. 129 144 - T 17-03-2017 IPR020785 Ribosomal protein L11, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 Hamap MF_00736 50S ribosomal protein L11 [rplK]. 8 144 31.892 T 17-03-2017 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 SUPERFAMILY SSF46906 70 143 2.35E-27 T 17-03-2017 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 SMART SM00649 12 143 2.9E-88 T 17-03-2017 IPR000911 Ribosomal protein L11/L12 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 Pfam PF03946 Ribosomal protein L11, N-terminal domain 12 69 1.5E-29 T 17-03-2017 IPR020784 Ribosomal protein L11, N-terminal SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 Gene3D G3DSA:1.10.10.250 75 143 3.3E-33 T 17-03-2017 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 TIGRFAM TIGR01632 L11_bact: ribosomal protein uL11 6 143 7.3E-64 T 17-03-2017 IPR006519 Ribosomal protein L11, bacterial-type GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 SUPERFAMILY SSF54747 5 75 3.53E-30 T 17-03-2017 IPR020784 Ribosomal protein L11, N-terminal SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 Pfam PF00298 Ribosomal protein L11, RNA binding domain 74 142 1.7E-26 T 17-03-2017 IPR020783 Ribosomal protein L11, C-terminal GO:0003735|GO:0005840|GO:0006412 SHXM_RS31085 6f266c0c71bf51a7df43f2e29cfd9ca5 144 Gene3D G3DSA:3.30.1550.10 5 74 9.9E-39 T 17-03-2017 IPR020784 Ribosomal protein L11, N-terminal SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF81665 904 997 4.18E-48 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF81665 705 773 4.18E-48 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF81665 1333 1523 4.18E-48 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF81653 806 902 3.01E-20 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Pfam PF00122 E1-E2 ATPase 741 994 2.2E-41 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF55008 64 110 3.93E-6 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 1005 1011 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Pfam PF00689 Cation transporting ATPase, C-terminus 1368 1521 9.9E-15 T 17-03-2017 IPR006068 Cation-transporting P-type ATPase, C-terminal Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Gene3D G3DSA:3.30.70.100 64 109 1.7E-6 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Gene3D G3DSA:1.20.1110.10 1252 1521 1.1E-60 T 17-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Gene3D G3DSA:1.20.1110.10 714 770 1.1E-60 T 17-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 1247 1364 8.7E-28 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 808 1040 2.9E-26 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1003 1017 2.3E-28 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 843 857 2.3E-28 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1307 1319 2.3E-28 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1182 1193 2.3E-28 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1283 1302 2.3E-28 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1204 1214 2.3E-28 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1315 1340 5.8E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1283 1299 5.8E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1139 1157 5.8E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1255 1271 5.8E-17 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF56784 1136 1388 9.7E-49 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 SUPERFAMILY SSF56784 1001 1021 9.7E-49 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Pfam PF00702 haloacid dehalogenase-like hydrolase 999 1297 1.1E-29 T 17-03-2017 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Gene3D G3DSA:2.70.150.10 806 903 7.9E-21 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS07280 50ecee4688589f9d6b0fcaa220e866a7 1539 Gene3D G3DSA:3.40.1110.10 994 1188 6.7E-28 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS02950 6fc6df5383df8bf322ed6c1c6b5242cc 399 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 235 248 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS02950 6fc6df5383df8bf322ed6c1c6b5242cc 399 Gene3D G3DSA:3.40.640.10 44 274 1.9E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS02950 6fc6df5383df8bf322ed6c1c6b5242cc 399 Pfam PF00155 Aminotransferase class I and II 31 391 7.6E-72 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS02950 6fc6df5383df8bf322ed6c1c6b5242cc 399 Gene3D G3DSA:3.90.1150.10 275 394 6.7E-40 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS02950 6fc6df5383df8bf322ed6c1c6b5242cc 399 SUPERFAMILY SSF53383 3 394 1.38E-110 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS25315 e20acb8d0b89f57a35d818eae5cfaee4 404 Gene3D G3DSA:3.40.50.300 104 277 1.8E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25315 e20acb8d0b89f57a35d818eae5cfaee4 404 Pfam PF07728 AAA domain (dynein-related subfamily) 122 260 2.2E-35 T 17-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 SHXM_RS25315 e20acb8d0b89f57a35d818eae5cfaee4 404 SUPERFAMILY SSF52540 100 381 7.14E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 220 442 6.1E-61 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 73 215 2.7E-34 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 TIGRFAM TIGR00666 PBP4: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 220 423 1.2E-36 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 SUPERFAMILY SSF56601 76 447 4.91E-62 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 329 343 3.1E-21 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 256 278 3.1E-21 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 110 129 3.1E-21 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 314 328 3.1E-21 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 Gene3D G3DSA:3.40.710.10 221 446 6.2E-51 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS42680 67ce435a5f9599f10da02584d49dc807 448 Gene3D G3DSA:3.40.710.10 90 148 1.6E-5 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS41545 374cce6e28c02b828c47ce13d857c30d 373 Gene3D G3DSA:3.20.20.30 1 336 1.2E-79 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS41545 374cce6e28c02b828c47ce13d857c30d 373 SUPERFAMILY SSF51679 1 333 1.09E-71 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS41545 374cce6e28c02b828c47ce13d857c30d 373 TIGRFAM TIGR04036 LLM_CE1758_fam: putative luciferase-like monooxygenase, FMN-dependent, CE1758 family 1 354 4.0E-203 T 17-03-2017 IPR023934 Luciferase-like monooxygenase, FMN-dependent, putative SHXM_RS41545 374cce6e28c02b828c47ce13d857c30d 373 Pfam PF00296 Luciferase-like monooxygenase 1 290 4.2E-56 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS25835 0b30daa347e9005d43df35d04cf8ea9b 312 SUPERFAMILY SSF53697 118 285 5.56E-40 T 17-03-2017 SHXM_RS25835 0b30daa347e9005d43df35d04cf8ea9b 312 Pfam PF01418 Helix-turn-helix domain, rpiR family 25 94 7.2E-13 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS25835 0b30daa347e9005d43df35d04cf8ea9b 312 Pfam PF01380 SIS domain 151 280 6.0E-23 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS25835 0b30daa347e9005d43df35d04cf8ea9b 312 Gene3D G3DSA:3.40.50.10490 120 288 3.4E-42 T 17-03-2017 SHXM_RS25835 0b30daa347e9005d43df35d04cf8ea9b 312 Gene3D G3DSA:1.10.10.10 25 98 5.4E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25835 0b30daa347e9005d43df35d04cf8ea9b 312 SUPERFAMILY SSF46689 27 96 7.17E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 Pfam PF00574 Clp protease 20 200 4.5E-68 T 17-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 9 201 36.226 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 SUPERFAMILY SSF52096 17 202 3.61E-56 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 Gene3D G3DSA:3.90.226.10 10 200 7.8E-67 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 PRINTS PR00127 Clp protease catalytic subunit P signature 96 113 5.3E-38 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 PRINTS PR00127 Clp protease catalytic subunit P signature 117 136 5.3E-38 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 PRINTS PR00127 Clp protease catalytic subunit P signature 176 195 5.3E-38 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 PRINTS PR00127 Clp protease catalytic subunit P signature 25 40 5.3E-38 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 PRINTS PR00127 Clp protease catalytic subunit P signature 65 85 5.3E-38 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS08490 63f66e79b853e7dce5d4e321a07e26d6 211 ProSitePatterns PS00381 Endopeptidase Clp serine active site. 96 107 - T 17-03-2017 IPR018215 ClpP, Ser active site SHXM_RS14560 c3ccfb4ce82cc12e9b98822e620e8da9 357 Gene3D G3DSA:3.40.50.150 110 342 2.6E-55 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14560 c3ccfb4ce82cc12e9b98822e620e8da9 357 SUPERFAMILY SSF46785 19 106 3.46E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14560 c3ccfb4ce82cc12e9b98822e620e8da9 357 Gene3D G3DSA:1.10.10.10 20 109 1.1E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14560 c3ccfb4ce82cc12e9b98822e620e8da9 357 Pfam PF00891 O-methyltransferase 121 334 2.6E-34 T 17-03-2017 IPR001077 O-methyltransferase, family 2 GO:0008171 SHXM_RS14560 c3ccfb4ce82cc12e9b98822e620e8da9 357 SUPERFAMILY SSF53335 107 342 6.19E-42 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14560 c3ccfb4ce82cc12e9b98822e620e8da9 357 PIRSF PIRSF005739 23 348 2.1E-42 T 17-03-2017 IPR016461 O-methyltransferase COMT-type GO:0008168 SHXM_RS02680 e0f7b05ce3d8eb728a07d811ba77bb93 102 SUPERFAMILY SSF46785 6 100 7.54E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02680 e0f7b05ce3d8eb728a07d811ba77bb93 102 SMART SM00418 9 100 4.3E-15 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS02680 e0f7b05ce3d8eb728a07d811ba77bb93 102 Pfam PF12840 Helix-turn-helix domain 9 79 4.1E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02680 e0f7b05ce3d8eb728a07d811ba77bb93 102 Gene3D G3DSA:1.10.10.10 4 100 2.5E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45065 13295fe1915549a59edd0a6d3d9ef0ed 297 Pfam PF13653 Glycerophosphoryl diester phosphodiesterase family 252 287 6.2E-8 T 17-03-2017 SHXM_RS45065 13295fe1915549a59edd0a6d3d9ef0ed 297 SUPERFAMILY SSF51695 217 289 6.8E-14 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS45065 13295fe1915549a59edd0a6d3d9ef0ed 297 SUPERFAMILY SSF51695 52 174 6.8E-14 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS45065 13295fe1915549a59edd0a6d3d9ef0ed 297 Gene3D G3DSA:3.20.20.190 107 295 3.1E-5 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 Gene3D G3DSA:3.40.50.720 12 252 2.0E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 Pfam PF00106 short chain dehydrogenase 16 207 9.5E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 146 154 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 167 186 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 91 102 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 8.3E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 167 186 8.3E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 140 156 8.3E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 8.3E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 188 205 8.3E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42165 83061207a595ff5902a1bf86ccbe6479 278 SUPERFAMILY SSF51735 13 256 2.64E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 134 150 1.3E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 103 116 1.3E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 14 25 1.3E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 SUPERFAMILY SSF56784 6 220 1.76E-44 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 Gene3D G3DSA:3.40.50.1000 10 28 2.9E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 Gene3D G3DSA:3.40.50.1000 94 223 2.9E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12000 f563b50de9baf8c0a6fc4000862066e4 237 Pfam PF13419 Haloacid dehalogenase-like hydrolase 17 191 3.1E-27 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 Hamap MF_00148 Uracil-DNA glycosylase [ung]. 6 220 40.393 T 17-03-2017 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 Gene3D G3DSA:3.40.470.10 5 221 7.5E-94 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 SMART SM00986 50 209 4.3E-33 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 SUPERFAMILY SSF52141 3 220 4.49E-88 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 SMART SM00987 50 209 4.3E-33 T 17-03-2017 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 ProSitePatterns PS00130 Uracil-DNA glycosylase signature. 58 67 - T 17-03-2017 IPR018085 Uracil-DNA glycosylase, active site GO:0006281|GO:0016799 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 Pfam PF03167 Uracil DNA glycosylase superfamily 55 205 1.0E-22 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06190 0ef7c1b4a3abff6fda22d3a2a461e697 226 TIGRFAM TIGR00628 ung: uracil-DNA glycosylase 7 212 3.5E-78 T 17-03-2017 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Pfam PF04851 Type III restriction enzyme, res subunit 25 145 4.2E-8 T 17-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Gene3D G3DSA:4.10.860.10 658 706 3.8E-11 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 SMART SM00487 18 433 2.4E-26 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Pfam PF02151 UvrB/uvrC motif 668 702 5.2E-6 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 SUPERFAMILY SSF52540 466 591 1.39E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 SUPERFAMILY SSF52540 42 91 1.39E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Pfam PF12344 Ultra-violet resistance protein B 559 600 3.1E-19 T 17-03-2017 IPR024759 UvrB, YAD/RRR-motif-containing domain SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 SMART SM00490 467 553 4.0E-18 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Pfam PF00271 Helicase conserved C-terminal domain 439 552 3.4E-19 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Gene3D G3DSA:3.40.50.300 425 588 2.2E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 TIGRFAM TIGR00631 uvrb: excinuclease ABC subunit B 14 700 0.0 T 17-03-2017 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Gene3D G3DSA:3.30.2060.10 169 237 1.6E-11 T 17-03-2017 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 SUPERFAMILY SSF52540 13 422 1.19E-132 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Gene3D G3DSA:3.40.50.300 15 98 5.4E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Gene3D G3DSA:3.40.50.300 286 346 5.4E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Gene3D G3DSA:3.40.50.300 396 416 5.4E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 Hamap MF_00204 UvrABC system protein B [uvrB]. 12 702 42.353 T 17-03-2017 IPR004807 UvrABC system, subunit B GO:0003677|GO:0005524|GO:0006281|GO:0006289|GO:0009381|GO:0009432 SHXM_RS18005 df698bee929149a72172c906faa98fa9 712 SUPERFAMILY SSF46600 661 705 1.01E-8 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 PIRSF PIRSF036978 17 357 6.1E-171 T 17-03-2017 IPR017078 Uncharacterised conserved protein UCP036978, histidinol phosphatase-related hydrolase, SCO0789 SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 SMART SM00481 122 201 5.9E-15 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 SUPERFAMILY SSF47802 21 99 5.23E-11 T 17-03-2017 IPR010996 DNA polymerase beta-like, N-terminal domain SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 SUPERFAMILY SSF89550 121 354 8.63E-47 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 Gene3D G3DSA:3.20.20.140 121 355 4.6E-44 T 17-03-2017 SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 Gene3D G3DSA:1.10.8.310 22 95 2.0E-7 T 17-03-2017 IPR027420 DNA polymerase beta, N-terminal domain SHXM_RS46235 28715fa74d686209e3b6e39e75f3b834 363 Pfam PF14716 Helix-hairpin-helix domain 23 87 2.4E-11 T 17-03-2017 IPR010996 DNA polymerase beta-like, N-terminal domain SHXM_RS04565 28bfa337ad8e28bcf02610770114314c 64 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 3.6E-5 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS04565 28bfa337ad8e28bcf02610770114314c 64 PRINTS PR00352 3Fe-4S ferredoxin signature 16 26 3.6E-5 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS04565 28bfa337ad8e28bcf02610770114314c 64 PRINTS PR00352 3Fe-4S ferredoxin signature 5 16 3.6E-5 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS04565 28bfa337ad8e28bcf02610770114314c 64 Gene3D G3DSA:3.30.70.20 1 64 5.9E-16 T 17-03-2017 SHXM_RS04565 28bfa337ad8e28bcf02610770114314c 64 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 5 61 5.6E-12 T 17-03-2017 SHXM_RS04565 28bfa337ad8e28bcf02610770114314c 64 SUPERFAMILY SSF54862 2 62 5.23E-12 T 17-03-2017 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 SMART SM00354 13 83 1.1E-28 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 SUPERFAMILY SSF47413 13 70 1.87E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 Gene3D G3DSA:3.40.50.2300 181 347 7.4E-59 T 17-03-2017 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 Pfam PF00356 Bacterial regulatory proteins, lacI family 15 60 6.3E-18 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 Gene3D G3DSA:1.10.260.40 13 67 1.1E-23 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 SUPERFAMILY SSF53822 86 347 3.0E-66 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 Pfam PF13377 Periplasmic binding protein-like domain 184 348 7.6E-35 T 17-03-2017 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 Gene3D G3DSA:3.40.50.2300 68 180 1.0E-22 T 17-03-2017 SHXM_RS22765 4ebdbb075523726cba9b04332311eb15 348 ProSitePatterns PS00356 LacI-type HTH domain signature. 16 34 - T 17-03-2017 SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 Gene3D G3DSA:1.10.10.10 1 52 3.0E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 SUPERFAMILY SSF46785 1 60 1.27E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 SMART SM00344 1 108 1.0E-37 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 8.4E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 8.4E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 8.4E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 ProSitePatterns PS00519 AsnC-type HTH domain signature. 19 45 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 SUPERFAMILY SSF54909 61 143 1.3E-17 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 Gene3D G3DSA:3.30.70.920 54 144 1.3E-23 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 Pfam PF13404 AsnC-type helix-turn-helix domain 1 42 9.6E-17 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS30650 98363094a093e8943f52ffc16ad72e11 153 Pfam PF01037 Lrp/AsnC ligand binding domain 67 138 4.5E-18 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 SUPERFAMILY SSF53383 113 441 3.66E-52 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 Gene3D G3DSA:1.10.10.10 33 98 3.2E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 SUPERFAMILY SSF46785 33 101 1.81E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 Pfam PF00155 Aminotransferase class I and II 130 440 2.3E-16 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 Pfam PF00392 Bacterial regulatory proteins, gntR family 32 93 5.7E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 Gene3D G3DSA:3.40.640.10 144 355 9.3E-37 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS26185 b4b1049db847ca94881eb872cc48b72a 466 SMART SM00345 34 93 1.9E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 PIRSF PIRSF001589 1 606 3.2E-137 T 17-03-2017 SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 SUPERFAMILY SSF56235 1 224 6.64E-64 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 SUPERFAMILY SSF52402 453 569 1.53E-57 T 17-03-2017 SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 SUPERFAMILY SSF52402 219 397 1.53E-57 T 17-03-2017 SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 Gene3D G3DSA:3.60.20.10 1 222 1.9E-72 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 Pfam PF00733 Asparagine synthase 240 598 3.3E-80 T 17-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 TIGRFAM TIGR01536 asn_synth_AEB: asparagine synthase (glutamine-hydrolyzing) 2 536 8.4E-140 T 17-03-2017 IPR006426 Asparagine synthase, glutamine-hydrolyzing GO:0004066|GO:0006529 KEGG: 00250+6.3.5.4|Reactome: R-HSA-380994|Reactome: R-HSA-70614 SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 Gene3D G3DSA:3.40.50.620 223 417 1.1E-70 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 Gene3D G3DSA:3.40.50.620 452 599 1.1E-70 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS42965 ab96d3e755b372dedee9cc6dcdf6bdd6 608 Pfam PF13537 Glutamine amidotransferase domain 48 168 2.3E-45 T 17-03-2017 IPR017932 Glutamine amidotransferase type 2 domain SHXM_RS30665 1765396c99fbcf7a0a347961ea4243e6 88 Gene3D G3DSA:1.20.1250.20 6 65 6.1E-4 T 17-03-2017 SHXM_RS30665 1765396c99fbcf7a0a347961ea4243e6 88 Pfam PF14012 Protein of unknown function (DUF4229) 3 73 2.7E-23 T 17-03-2017 IPR025323 Protein of unknown function DUF4229 SHXM_RS10440 67c1629d6762e2bbb939e8fb3aeb3021 177 Gene3D G3DSA:2.160.10.10 11 172 3.9E-48 T 17-03-2017 SHXM_RS10440 67c1629d6762e2bbb939e8fb3aeb3021 177 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 91 124 5.6E-6 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS10440 67c1629d6762e2bbb939e8fb3aeb3021 177 SUPERFAMILY SSF51161 10 172 7.62E-48 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS30180 3a630e145972d949491fef4088687e06 218 Pfam PF00072 Response regulator receiver domain 3 113 5.6E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30180 3a630e145972d949491fef4088687e06 218 Gene3D G3DSA:1.10.10.10 126 217 2.9E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30180 3a630e145972d949491fef4088687e06 218 SMART SM00448 1 112 5.3E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30180 3a630e145972d949491fef4088687e06 218 Gene3D G3DSA:3.40.50.2300 1 118 4.8E-32 T 17-03-2017 SHXM_RS30180 3a630e145972d949491fef4088687e06 218 SUPERFAMILY SSF52172 1 171 1.42E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS30180 3a630e145972d949491fef4088687e06 218 SMART SM00862 145 217 3.0E-17 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS30180 3a630e145972d949491fef4088687e06 218 Pfam PF00486 Transcriptional regulatory protein, C terminal 145 217 1.5E-18 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS34040 13899c386902781f8bd3286955becf12 373 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 229 242 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS34040 13899c386902781f8bd3286955becf12 373 Gene3D G3DSA:3.40.640.10 43 249 1.6E-43 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS34040 13899c386902781f8bd3286955becf12 373 Pfam PF00155 Aminotransferase class I and II 30 371 8.7E-48 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS34040 13899c386902781f8bd3286955becf12 373 TIGRFAM TIGR03539 DapC_actino: succinyldiaminopimelate transaminase 8 371 3.8E-176 T 17-03-2017 IPR019880 Succinyldiaminopimelate transaminase, DapC, actinobacteria SHXM_RS34040 13899c386902781f8bd3286955becf12 373 Gene3D G3DSA:3.90.1150.10 250 372 1.5E-21 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS34040 13899c386902781f8bd3286955becf12 373 SUPERFAMILY SSF53383 7 372 3.99E-80 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS36290 0839fc19937b26e9bfdf8487f8b88777 140 Pfam PF03259 Roadblock/LC7 domain 12 102 5.1E-25 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS36290 0839fc19937b26e9bfdf8487f8b88777 140 SMART SM00960 12 102 6.6E-32 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS36290 0839fc19937b26e9bfdf8487f8b88777 140 SUPERFAMILY SSF103196 4 128 1.19E-31 T 17-03-2017 SHXM_RS36290 0839fc19937b26e9bfdf8487f8b88777 140 Gene3D G3DSA:3.30.450.30 6 126 3.7E-25 T 17-03-2017 SHXM_RS18010 f81a1844a9a693414a02c7aa547ace9a 294 Gene3D G3DSA:3.20.20.190 18 292 1.1E-75 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS18010 f81a1844a9a693414a02c7aa547ace9a 294 SUPERFAMILY SSF51695 38 290 1.88E-70 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS18010 f81a1844a9a693414a02c7aa547ace9a 294 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 43 284 4.0E-42 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS04960 08c5a201e9f23948f5c69c057f2a61e5 378 Gene3D G3DSA:3.40.50.1820 3 372 8.4E-85 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04960 08c5a201e9f23948f5c69c057f2a61e5 378 Pfam PF00135 Carboxylesterase family 298 370 2.2E-4 T 17-03-2017 IPR002018 Carboxylesterase, type B SHXM_RS04960 08c5a201e9f23948f5c69c057f2a61e5 378 Pfam PF00135 Carboxylesterase family 3 279 1.9E-61 T 17-03-2017 IPR002018 Carboxylesterase, type B SHXM_RS04960 08c5a201e9f23948f5c69c057f2a61e5 378 SUPERFAMILY SSF53474 3 373 6.1E-78 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 Pfam PF00557 Metallopeptidase family M24 48 276 2.1E-53 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 Gene3D G3DSA:3.90.230.10 41 284 3.7E-96 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 41 283 8.0E-90 T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 Hamap MF_01974 Methionine aminopeptidase [map]. 39 285 39.9 T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 104 117 3.8E-20 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 126 142 3.8E-20 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 227 239 3.8E-20 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 PRINTS PR00599 Methionine aminopeptidase-1 signature 196 208 3.8E-20 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 ProSitePatterns PS00680 Methionine aminopeptidase subfamily 1 signature. 202 220 - T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS19480 14927026c6d688f55694f6d3fe8ff976 285 SUPERFAMILY SSF55920 6 284 6.67E-87 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS46555 8c1008d30c039363070bb17dde3a4f5a 90 Pfam PF00550 Phosphopantetheine attachment site 13 80 5.7E-7 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46555 8c1008d30c039363070bb17dde3a4f5a 90 Gene3D G3DSA:1.10.1200.10 4 85 1.4E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46555 8c1008d30c039363070bb17dde3a4f5a 90 SUPERFAMILY SSF47336 9 85 1.31E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 2.6E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 2.6E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 11 28 2.6E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 2.6E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 SUPERFAMILY SSF51735 6 265 1.96E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 10 189 0.0011 T 17-03-2017 SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 3.9E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 3.9E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 3.9E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 Gene3D G3DSA:3.40.50.720 3 210 1.4E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32535 5044c9c42d98ae9ff91bc73eaf58ef3f 301 Pfam PF00106 short chain dehydrogenase 10 198 2.4E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS28265 1d71c40393abf3d53d2a46e735f64c35 172 SUPERFAMILY SSF49879 48 171 8.23E-29 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS28265 1d71c40393abf3d53d2a46e735f64c35 172 Pfam PF00498 FHA domain 99 164 1.5E-15 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS28265 1d71c40393abf3d53d2a46e735f64c35 172 SMART SM00240 98 149 3.6E-13 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS28265 1d71c40393abf3d53d2a46e735f64c35 172 Gene3D G3DSA:2.60.200.20 78 171 1.8E-27 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 SUPERFAMILY SSF51735 329 510 5.8E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 SUPERFAMILY SSF48179 206 312 6.72E-27 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 513 609 2.8E-32 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 207 303 9.3E-28 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 333 510 1.4E-56 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 26 204 2.9E-57 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 SUPERFAMILY SSF51735 25 206 3.84E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 SUPERFAMILY SSF48179 513 610 3.66E-28 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Gene3D G3DSA:3.40.50.720 327 514 1.5E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Gene3D G3DSA:3.40.50.720 22 208 3.5E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Gene3D G3DSA:1.10.1040.10 209 304 2.1E-28 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS14710 956c8f5818fe079ab9c00739626fb9e5 612 Gene3D G3DSA:1.10.1040.10 515 609 4.5E-31 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 PIRSF PIRSF001399 1 145 5.4E-49 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 Gene3D G3DSA:3.40.50.9100 3 142 9.6E-50 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 147 52.186 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 ProSitePatterns PS01029 Dehydroquinase class II signature. 7 24 - T 17-03-2017 IPR018509 Dehydroquinase, class II, conserved site GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 Pfam PF01220 Dehydroquinase class II 4 139 1.1E-45 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 SUPERFAMILY SSF52304 4 143 1.57E-50 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS39680 6be9bb910e35ca5367ce5b9f2ed3f40b 147 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 17 125 1.0E-55 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 TIGRFAM TIGR00459 aspS_bact: aspartate--tRNA ligase 5 583 2.8E-185 T 17-03-2017 IPR004524 Aspartate-tRNA ligase, bacterial/mitochondrial-type GO:0005524|GO:0016874 Reactome: R-HSA-379726 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 PRINTS PR01042 Aspartyl-tRNA synthetase signature 211 224 4.6E-21 T 17-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 PRINTS PR01042 Aspartyl-tRNA synthetase signature 194 206 4.6E-21 T 17-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 PRINTS PR01042 Aspartyl-tRNA synthetase signature 516 530 4.6E-21 T 17-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 PRINTS PR01042 Aspartyl-tRNA synthetase signature 472 488 4.6E-21 T 17-03-2017 IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 SUPERFAMILY SSF50249 4 107 1.89E-27 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Pfam PF02938 GAD domain 316 403 2.5E-19 T 17-03-2017 IPR029351 GAD domain Reactome: R-HSA-379726 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 SUPERFAMILY SSF55681 115 298 1.43E-93 T 17-03-2017 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 SUPERFAMILY SSF55681 422 582 1.43E-93 T 17-03-2017 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Gene3D G3DSA:2.40.50.140 4 108 1.3E-33 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Pfam PF01336 OB-fold nucleic acid binding domain 21 104 1.8E-14 T 17-03-2017 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 SUPERFAMILY SSF55261 297 414 8.07E-33 T 17-03-2017 IPR004115 GAD-like domain GO:0004812|GO:0005524|GO:0005737 Reactome: R-HSA-379726 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Pfam PF00152 tRNA synthetases class II (D, K and N) 122 555 3.2E-94 T 17-03-2017 IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N) GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Gene3D G3DSA:3.30.1360.30 283 410 4.4E-40 T 17-03-2017 IPR004115 GAD-like domain GO:0004812|GO:0005524|GO:0005737 Reactome: R-HSA-379726 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Hamap MF_00044 Aspartate--tRNA(Asp) ligase [aspS]. 4 561 32.851 T 17-03-2017 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Gene3D G3DSA:3.30.930.10 136 282 4.3E-98 T 17-03-2017 SHXM_RS28530 35b46579cce5a5d31ae5993dc0a4e836 620 Gene3D G3DSA:3.30.930.10 411 583 4.3E-98 T 17-03-2017 SHXM_RS43655 517591cbfc5de8653f0de238d67ce1e2 511 Pfam PF08447 PAS fold 143 226 7.4E-9 T 17-03-2017 IPR013655 PAS fold-3 GO:0005515 SHXM_RS43655 517591cbfc5de8653f0de238d67ce1e2 511 SUPERFAMILY SSF55785 142 245 5.39E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS43655 517591cbfc5de8653f0de238d67ce1e2 511 Gene3D G3DSA:3.30.450.20 130 234 1.1E-12 T 17-03-2017 SHXM_RS43655 517591cbfc5de8653f0de238d67ce1e2 511 SMART SM00331 299 506 2.8E-14 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS43655 517591cbfc5de8653f0de238d67ce1e2 511 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 325 506 9.4E-36 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 218 238 1.7E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 183 200 1.7E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 1.7E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 23 40 1.7E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 89 100 1.7E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 181 1.7E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 Gene3D G3DSA:3.40.50.720 17 257 1.5E-79 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 149 177 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 SUPERFAMILY SSF51735 20 256 1.15E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 1.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 89 100 1.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 162 181 1.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02365 823d69ecec3e2c83cc4233e0d2122e01 265 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 28 255 2.8E-59 T 17-03-2017 SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 SUPERFAMILY SSF56300 178 421 9.68E-43 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 Pfam PF00149 Calcineurin-like phosphoesterase 187 392 4.0E-12 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 SUPERFAMILY SSF56091 690 782 7.77E-9 T 17-03-2017 SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 SUPERFAMILY SSF56091 530 621 7.77E-9 T 17-03-2017 SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 Gene3D G3DSA:3.40.50.300 15 142 2.4E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 Pfam PF13671 AAA domain 15 144 3.6E-22 T 17-03-2017 SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 Pfam PF16542 PNKP adenylyltransferase domain, ligase domain 474 810 1.4E-142 T 17-03-2017 IPR032380 Polynucleotide kinase-phosphatase, ligase domain SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 Pfam PF16536 PNKP adenylyltransferase domain, C-terminal region 814 873 1.2E-31 T 17-03-2017 IPR032390 Polynucleotide kinase-phosphatase, C-terminal SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 TIGRFAM TIGR04075 bacter_Pnkp: polynucleotide kinase-phosphatase 8 873 0.0 T 17-03-2017 IPR024028 Polynucleotide kinase-phosphatase, bacterial SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 Gene3D G3DSA:3.60.21.10 182 431 2.7E-52 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS37945 c8316678a1c7e439d2aa98bf3895493a 873 SUPERFAMILY SSF52540 15 141 5.33E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 SUPERFAMILY SSF51445 184 627 3.41E-109 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 TIGRFAM TIGR01515 branching_enzym: 1,4-alpha-glucan branching enzyme 113 735 1.0E-294 T 17-03-2017 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 SMART SM00642 254 614 5.3E-8 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 SUPERFAMILY SSF81296 23 118 5.0E-19 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 SUPERFAMILY SSF51011 633 736 6.23E-30 T 17-03-2017 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Pfam PF00128 Alpha amylase, catalytic domain 271 343 1.3E-10 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Gene3D G3DSA:3.20.20.80 251 620 6.0E-90 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Gene3D G3DSA:2.60.40.1180 633 736 1.6E-32 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Hamap MF_00685 1,4-alpha-glucan branching enzyme GlgB [glgB]. 105 737 43.266 T 17-03-2017 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Gene3D G3DSA:2.60.40.10 22 110 1.8E-15 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Gene3D G3DSA:2.60.40.10 117 225 2.5E-35 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 PIRSF PIRSF000463 16 737 3.8E-291 T 17-03-2017 IPR006407 1,4-alpha-glucan-branching enzyme, GlgB GO:0003844|GO:0005978 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622|Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Pfam PF02806 Alpha amylase, C-terminal all-beta domain 638 736 4.4E-19 T 17-03-2017 IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta GO:0003824|GO:0005975|GO:0043169 KEGG: 00500+2.4.1.18|MetaCyc: PWY-5067|MetaCyc: PWY-622 SHXM_RS35695 46b0e5e06b044e56de57afd0db9a26e8 737 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 129 211 5.6E-20 T 17-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 SUPERFAMILY SSF51735 207 339 1.38E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 SMART SM00881 209 310 4.7E-25 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Gene3D G3DSA:3.40.50.261 341 504 8.7E-29 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 SUPERFAMILY SSF52210 514 670 6.67E-14 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 SUPERFAMILY SSF55729 24 175 9.04E-24 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Pfam PF13549 ATP-grasp domain 758 964 6.6E-54 T 17-03-2017 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Pfam PF13380 CoA binding domain 214 345 1.7E-16 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Gene3D G3DSA:3.30.470.20 763 835 1.3E-4 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Gene3D G3DSA:3.40.50.261 510 632 7.9E-8 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 SUPERFAMILY SSF52210 342 510 9.94E-31 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 SUPERFAMILY SSF56059 762 956 8.48E-25 T 17-03-2017 SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Gene3D G3DSA:3.40.50.720 195 340 8.5E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 363 505 7.7E-37 T 17-03-2017 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Gene3D G3DSA:3.40.630.30 19 183 6.7E-24 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS37540 1fcdef393ca72c7f152729d13151c87d 982 Pfam PF00583 Acetyltransferase (GNAT) family 86 168 2.2E-9 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 Pfam PF00005 ABC transporter 314 482 8.0E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 Pfam PF00005 ABC transporter 42 189 2.1E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 ProSitePatterns PS00211 ABC transporters family signature. 455 469 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 Gene3D G3DSA:3.40.50.300 17 263 5.9E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 Gene3D G3DSA:3.40.50.300 297 556 3.6E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 ProSitePatterns PS00211 ABC transporters family signature. 162 176 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 SUPERFAMILY SSF52540 298 554 1.21E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 SMART SM00382 50 239 1.0E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 SMART SM00382 322 532 4.3E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 241 273 3.2E-5 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 534 566 2.4E-7 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33300 90798f2bfdcfc43cc66d1a2d150943a6 604 SUPERFAMILY SSF52540 14 267 1.28E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04235 11f89a0d28e5c82f1e6a61151c569914 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 57 5.2E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04235 11f89a0d28e5c82f1e6a61151c569914 202 SUPERFAMILY SSF46689 2 80 1.13E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04235 11f89a0d28e5c82f1e6a61151c569914 202 Gene3D G3DSA:1.10.357.10 2 198 9.9E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 Gene3D G3DSA:3.30.360.10 301 456 3.5E-50 T 17-03-2017 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 250 263 2.6E-18 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 286 304 2.6E-18 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 369 386 2.6E-18 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 313 329 2.6E-18 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 SUPERFAMILY SSF51735 130 308 3.95E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 Gene3D G3DSA:3.40.50.720 130 300 1.0E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 130 292 4.6E-39 T 17-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 131 466 1.1E-110 T 17-03-2017 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 297 454 2.9E-43 T 17-03-2017 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 SMART SM00846 129 292 7.1E-51 T 17-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 ProSitePatterns PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 290 297 - T 17-03-2017 IPR020830 Glyceraldehyde 3-phosphate dehydrogenase, active site GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS45680 4f2715d8e7219bc0f99149984c1495e9 484 SUPERFAMILY SSF55347 292 455 7.44E-49 T 17-03-2017 SHXM_RS25210 27a72ee17cf921314f51b586ab6ce716 366 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 57 307 7.5E-105 T 17-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 SHXM_RS25210 27a72ee17cf921314f51b586ab6ce716 366 ProSitePatterns PS00211 ABC transporters family signature. 185 199 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS25210 27a72ee17cf921314f51b586ab6ce716 366 SUPERFAMILY SSF52540 60 289 2.26E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25210 27a72ee17cf921314f51b586ab6ce716 366 Gene3D G3DSA:3.40.50.300 53 285 2.2E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25210 27a72ee17cf921314f51b586ab6ce716 366 SMART SM00382 73 270 1.2E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS25210 27a72ee17cf921314f51b586ab6ce716 366 Pfam PF00005 ABC transporter 65 212 6.3E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30925 c401d926675d84782d977189f439a382 140 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 40 139 1.9E-30 T 17-03-2017 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30925 c401d926675d84782d977189f439a382 140 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 21 140 16.633 T 17-03-2017 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 Pfam PF06283 Trehalose utilisation 67 286 1.5E-72 T 17-03-2017 IPR029010 ThuA-like domain SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 Gene3D G3DSA:2.120.10.30 295 826 2.1E-86 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 SUPERFAMILY SSF52317 66 290 1.65E-35 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 Pfam PF07995 Glucose / Sorbosone dehydrogenase 391 622 7.5E-25 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 SUPERFAMILY SSF50952 318 642 1.44E-16 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 SUPERFAMILY SSF50952 707 801 1.44E-16 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS07815 db6c00a5660a4069e403fb1f586dc866 832 Gene3D G3DSA:3.40.50.880 65 294 2.0E-25 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS26530 0c84ad7a4f773d028c39225df83e0a7b 287 Gene3D G3DSA:1.10.260.40 14 71 1.3E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26530 0c84ad7a4f773d028c39225df83e0a7b 287 SMART SM00530 19 74 2.7E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS26530 0c84ad7a4f773d028c39225df83e0a7b 287 SUPERFAMILY SSF47413 13 71 2.56E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26530 0c84ad7a4f773d028c39225df83e0a7b 287 Pfam PF13560 Helix-turn-helix domain 16 78 1.5E-14 T 17-03-2017 SHXM_RS07535 ec9f94023d2fa2e29dd2cafba4ced718 389 SUPERFAMILY SSF51556 16 179 9.98E-14 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS07535 ec9f94023d2fa2e29dd2cafba4ced718 389 SUPERFAMILY SSF51556 209 381 9.98E-14 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS07535 ec9f94023d2fa2e29dd2cafba4ced718 389 Gene3D G3DSA:3.20.20.140 16 382 2.2E-122 T 17-03-2017 SHXM_RS16630 b402422e679e06f3ab70b928ba672d39 162 Pfam PF13359 DDE superfamily endonuclease 62 144 4.3E-14 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS08690 c05398c802ac84fe058e1db81402a0f2 200 SMART SM00947 26 191 8.2E-60 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS08690 c05398c802ac84fe058e1db81402a0f2 200 Gene3D G3DSA:3.40.1050.10 1 194 8.2E-60 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS08690 c05398c802ac84fe058e1db81402a0f2 200 Pfam PF00484 Carbonic anhydrase 33 186 3.1E-43 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS08690 c05398c802ac84fe058e1db81402a0f2 200 ProSitePatterns PS00705 Prokaryotic-type carbonic anhydrases signature 2. 82 102 - T 17-03-2017 IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site GO:0004089|GO:0008270|GO:0015976 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS08690 c05398c802ac84fe058e1db81402a0f2 200 ProSitePatterns PS00704 Prokaryotic-type carbonic anhydrases signature 1. 38 45 - T 17-03-2017 IPR015892 Carbonic anhydrase, prokaryotic-like, conserved site GO:0004089|GO:0008270|GO:0015976 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS08690 c05398c802ac84fe058e1db81402a0f2 200 SUPERFAMILY SSF53056 3 196 1.18E-53 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 Gene3D G3DSA:1.10.510.10 100 265 2.9E-44 T 17-03-2017 SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 SUPERFAMILY SSF56112 299 363 2.13E-66 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 SUPERFAMILY SSF56112 11 268 2.13E-66 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 133 145 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 Pfam PF00069 Protein kinase domain 15 263 4.0E-39 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 SMART SM00220 15 266 1.2E-47 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS30715 8b63db569ece7534096a1e203c3a9762 598 Gene3D G3DSA:3.30.200.20 9 80 7.4E-13 T 17-03-2017 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 Pfam PF00392 Bacterial regulatory proteins, gntR family 43 101 5.8E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 Pfam PF00155 Aminotransferase class I and II 142 428 6.6E-18 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 SUPERFAMILY SSF46785 36 104 2.36E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 61 75 5.0E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 75 91 5.0E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 SMART SM00345 42 101 2.2E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 Gene3D G3DSA:1.10.10.10 42 104 2.9E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 Gene3D G3DSA:3.40.640.10 157 376 1.6E-43 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS25185 fe03210edbd4702c057664bd362278e7 501 SUPERFAMILY SSF53383 96 500 1.06E-71 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 ProSitePatterns PS00455 Putative AMP-binding domain signature. 165 176 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 Gene3D G3DSA:2.30.38.10 347 413 3.9E-18 T 17-03-2017 SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 Pfam PF13193 AMP-binding enzyme C-terminal domain 428 502 1.1E-22 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 Gene3D G3DSA:3.30.300.30 416 518 8.7E-33 T 17-03-2017 SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 Gene3D G3DSA:3.40.50.980 172 317 1.3E-33 T 17-03-2017 SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 Pfam PF00501 AMP-binding enzyme 20 419 4.3E-85 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 SUPERFAMILY SSF56801 11 514 2.62E-136 T 17-03-2017 SHXM_RS48870 dd7b0618f9656be2dd51caf782534c80 521 Gene3D G3DSA:3.40.50.980 16 171 4.7E-31 T 17-03-2017 SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 SUPERFAMILY SSF52743 41 320 1.31E-65 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 PRINTS PR00723 Subtilisin serine protease family (S8) signature 98 111 1.0E-13 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 PRINTS PR00723 Subtilisin serine protease family (S8) signature 260 276 1.0E-13 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 PRINTS PR00723 Subtilisin serine protease family (S8) signature 59 78 1.0E-13 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 Pfam PF00082 Subtilase family 59 312 1.9E-39 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 Gene3D G3DSA:3.40.50.200 40 320 1.2E-67 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS37005 0450fdf2f6b7bcd62e6b1254f9309656 417 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 102 112 - T 17-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site SHXM_RS47290 e6a83855ffe4891b8f729bc81e5dc62f 312 Gene3D G3DSA:2.40.100.10 203 311 2.1E-5 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS47290 e6a83855ffe4891b8f729bc81e5dc62f 312 Pfam PF02626 Allophanate hydrolase subunit 2 52 308 1.5E-76 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS47290 e6a83855ffe4891b8f729bc81e5dc62f 312 SMART SM00797 51 312 2.6E-83 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS47290 e6a83855ffe4891b8f729bc81e5dc62f 312 TIGRFAM TIGR00724 urea_amlyse_rel: biotin-dependent carboxylase uncharacterized domain 30 311 1.8E-77 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS47290 e6a83855ffe4891b8f729bc81e5dc62f 312 SUPERFAMILY SSF50891 202 311 2.5E-10 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 SUPERFAMILY SSF69118 302 423 6.94E-35 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 Pfam PF00561 alpha/beta hydrolase fold 18 117 1.4E-16 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 86 99 2.6E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 2.6E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 199 213 2.6E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 PRINTS PR00111 Alpha/beta hydrolase fold signature 43 58 2.6E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 SUPERFAMILY SSF53474 6 253 6.91E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 TIGRFAM TIGR02425 decarb_PcaC: 4-carboxymuconolactone decarboxylase 303 422 3.7E-49 T 17-03-2017 IPR012788 4-carboxymuconolactone decarboxylase KEGG: 00362+4.1.1.44 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 Pfam PF02627 Carboxymuconolactone decarboxylase family 335 417 1.5E-24 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 Gene3D G3DSA:3.40.50.1820 6 254 2.5E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39115 a27b81e384113529dd2b42e9edd643bd 428 Gene3D G3DSA:1.20.1290.10 303 424 3.0E-26 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 SUPERFAMILY SSF55874 187 356 3.67E-40 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 PRINTS PR00344 Bacterial sensor protein C-terminal signature 318 336 2.1E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 PRINTS PR00344 Bacterial sensor protein C-terminal signature 342 355 2.1E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 PRINTS PR00344 Bacterial sensor protein C-terminal signature 306 316 2.1E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 PRINTS PR00344 Bacterial sensor protein C-terminal signature 288 302 2.1E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 SUPERFAMILY SSF55785 14 113 1.03E-10 T 17-03-2017 IPR000014 PAS domain SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 Gene3D G3DSA:3.30.450.20 14 67 2.3E-11 T 17-03-2017 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 Gene3D G3DSA:1.10.287.130 122 182 2.3E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 SMART SM00388 129 197 6.8E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 Gene3D G3DSA:3.30.565.10 183 356 7.6E-41 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 243 356 1.8E-23 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 Pfam PF00512 His Kinase A (phospho-acceptor) domain 131 197 3.2E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 SMART SM00387 242 358 3.5E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13125 c1f7a5e7434c56a7aa7dc1617e7e16a7 363 SUPERFAMILY SSF47384 120 198 8.83E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35860 fe326aedcc66a10af3ffc7f427c2fb6c 255 Gene3D G3DSA:3.90.226.10 2 247 2.5E-87 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS35860 fe326aedcc66a10af3ffc7f427c2fb6c 255 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 96 116 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS35860 fe326aedcc66a10af3ffc7f427c2fb6c 255 SUPERFAMILY SSF52096 3 253 2.49E-83 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS35860 fe326aedcc66a10af3ffc7f427c2fb6c 255 Pfam PF00378 Enoyl-CoA hydratase/isomerase 8 248 2.1E-68 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS31205 e12aa9b0e3befa36e289df0e0a9551d6 74 TIGRFAM TIGR00012 L29: ribosomal protein uL29 9 64 3.8E-22 T 17-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31205 e12aa9b0e3befa36e289df0e0a9551d6 74 ProSitePatterns PS00579 Ribosomal protein L29 signature. 43 57 - T 17-03-2017 IPR018254 Ribosomal protein L29, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31205 e12aa9b0e3befa36e289df0e0a9551d6 74 SUPERFAMILY SSF46561 5 67 5.49E-24 T 17-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31205 e12aa9b0e3befa36e289df0e0a9551d6 74 Hamap MF_00374 50S ribosomal protein L29 [rpmC]. 5 64 17.943 T 17-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31205 e12aa9b0e3befa36e289df0e0a9551d6 74 Pfam PF00831 Ribosomal L29 protein 8 64 2.7E-26 T 17-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31205 e12aa9b0e3befa36e289df0e0a9551d6 74 Gene3D G3DSA:1.10.287.310 6 69 4.7E-32 T 17-03-2017 IPR001854 Ribosomal protein L29 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS42515 76fbeacf2f4756d5565b6989945a29c7 445 Pfam PF07730 Histidine kinase 252 319 3.0E-13 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS42515 76fbeacf2f4756d5565b6989945a29c7 445 SUPERFAMILY SSF55874 328 441 2.48E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 Gene3D G3DSA:3.40.190.10 183 268 2.7E-13 T 17-03-2017 SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 SUPERFAMILY SSF53850 92 296 1.78E-24 T 17-03-2017 SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 1.7E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 1.7E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 1.7E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 Pfam PF03466 LysR substrate binding domain 93 293 1.5E-26 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 Gene3D G3DSA:1.10.10.10 6 84 2.3E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 Gene3D G3DSA:3.40.190.10 94 182 5.8E-16 T 17-03-2017 SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 SUPERFAMILY SSF46785 7 112 3.14E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01310 b608c182f003f32c1fda5d95ae9c3fb4 297 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 8 63 1.4E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 273 280 1.3E-6 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 99 108 1.3E-6 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 235 249 1.3E-6 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 153 171 9.4E-20 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 1 9 9.4E-20 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 234 250 9.4E-20 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 258 280 9.4E-20 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 96 114 9.4E-20 T 17-03-2017 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 SUPERFAMILY SSF51905 152 311 3.31E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 Gene3D G3DSA:3.50.50.60 1 99 7.6E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 SUPERFAMILY SSF55424 316 394 1.07E-19 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 SUPERFAMILY SSF51905 1 195 3.1E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 Gene3D G3DSA:3.30.390.30 324 396 2.1E-18 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 1 303 1.8E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 Gene3D G3DSA:3.50.50.60 100 311 3.8E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19950 b38483a3fd395363aa536e88a961d03f 406 Pfam PF14759 Reductase C-terminal 324 394 1.4E-12 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS41885 2d7cc4a9d1999901cbcc32b9a90bb20d 429 ProSitePatterns PS00913 Iron-containing alcohol dehydrogenases signature 1. 187 215 - T 17-03-2017 IPR018211 Alcohol dehydrogenase, iron-type, conserved site GO:0016491|GO:0046872|GO:0055114 SHXM_RS41885 2d7cc4a9d1999901cbcc32b9a90bb20d 429 Gene3D G3DSA:3.40.50.1970 19 198 9.4E-49 T 17-03-2017 SHXM_RS41885 2d7cc4a9d1999901cbcc32b9a90bb20d 429 SUPERFAMILY SSF56796 18 424 2.62E-98 T 17-03-2017 SHXM_RS41885 2d7cc4a9d1999901cbcc32b9a90bb20d 429 Gene3D G3DSA:1.20.1090.10 199 426 6.8E-57 T 17-03-2017 SHXM_RS41885 2d7cc4a9d1999901cbcc32b9a90bb20d 429 Pfam PF00465 Iron-containing alcohol dehydrogenase 20 418 5.1E-105 T 17-03-2017 IPR001670 Alcohol dehydrogenase, iron-type GO:0016491|GO:0046872|GO:0055114 Reactome: R-HSA-880009 SHXM_RS03995 7ea043aaef623cdb0972c65c124e6a03 133 Pfam PF07179 SseB protein N-terminal domain 14 123 8.5E-12 T 17-03-2017 IPR009839 SseB protein N-terminal domain SHXM_RS33510 3848a20172a24c4cef27998254e30130 248 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 166 176 2.3E-6 T 17-03-2017 IPR014032 Peptidase A24A, prepilin type IV, bacterial SHXM_RS33510 3848a20172a24c4cef27998254e30130 248 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 109 126 2.3E-6 T 17-03-2017 IPR014032 Peptidase A24A, prepilin type IV, bacterial SHXM_RS33510 3848a20172a24c4cef27998254e30130 248 PRINTS PR00864 Type IV prepilin cysteine protease (C20) family signature 177 188 2.3E-6 T 17-03-2017 IPR014032 Peptidase A24A, prepilin type IV, bacterial SHXM_RS33510 3848a20172a24c4cef27998254e30130 248 Pfam PF01478 Type IV leader peptidase family 101 207 2.5E-13 T 17-03-2017 IPR000045 Prepilin type IV endopeptidase, peptidase domain GO:0004190|GO:0016020 SHXM_RS28260 987f43c0d4fe4319b4e7fcf0354d15d0 528 Pfam PF00481 Protein phosphatase 2C 22 225 2.1E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28260 987f43c0d4fe4319b4e7fcf0354d15d0 528 SMART SM00331 11 237 1.1E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28260 987f43c0d4fe4319b4e7fcf0354d15d0 528 SUPERFAMILY SSF81606 4 236 9.16E-66 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28260 987f43c0d4fe4319b4e7fcf0354d15d0 528 Gene3D G3DSA:3.60.40.10 2 237 2.9E-73 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28260 987f43c0d4fe4319b4e7fcf0354d15d0 528 SMART SM00332 2 235 2.3E-29 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06005 0b75d653dad6518424949693778201e3 123 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 4 116 4.9E-6 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS06005 0b75d653dad6518424949693778201e3 123 SUPERFAMILY SSF54593 3 120 6.98E-22 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS06005 0b75d653dad6518424949693778201e3 123 Gene3D G3DSA:3.10.180.10 2 118 2.2E-16 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Pfam PF01820 D-ala D-ala ligase N-terminus 23 155 4.5E-34 T 17-03-2017 IPR011127 D-alanine--D-alanine ligase, N-terminal domain KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Gene3D G3DSA:3.30.470.20 252 383 5.0E-47 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Gene3D G3DSA:3.30.470.20 155 172 5.0E-47 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 SUPERFAMILY SSF52440 21 164 4.03E-35 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Pfam PF07478 D-ala D-ala ligase C-terminus 174 380 1.2E-67 T 17-03-2017 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 TIGRFAM TIGR01205 D_ala_D_alaTIGR: D-alanine--D-alanine ligase 23 382 1.9E-106 T 17-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 ProSitePatterns PS00843 D-alanine--D-alanine ligase signature 1. 132 143 - T 17-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 SUPERFAMILY SSF56059 165 384 2.42E-54 T 17-03-2017 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 PIRSF PIRSF039102 19 389 1.1E-111 T 17-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Gene3D G3DSA:3.30.1490.20 176 251 3.1E-23 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Gene3D G3DSA:3.40.50.20 21 154 4.5E-37 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 Hamap MF_00047 D-alanine--D-alanine ligase [ddl]. 22 383 41.983 T 17-03-2017 IPR005905 D-alanine--D-alanine ligase GO:0005737|GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS36390 799df9cc2a3a6996659676f4f28f29f1 390 ProSitePatterns PS00844 D-alanine--D-alanine ligase signature 2. 325 353 - T 17-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 Gene3D G3DSA:1.20.1270.50 522 616 6.8E-24 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 SMART SM00872 519 597 1.2E-38 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 SUPERFAMILY SSF74650 625 1040 7.22E-74 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 Pfam PF09261 Alpha mannosidase middle domain 519 597 3.1E-27 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 627 1038 2.0E-75 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 255 511 6.9E-89 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 SUPERFAMILY SSF88713 251 517 1.87E-81 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 SUPERFAMILY SSF88688 518 616 5.56E-27 T 17-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain SHXM_RS46995 e981ae92bd41dccdfeb4cc37e2559d1a 1042 Gene3D G3DSA:3.20.110.10 203 521 2.5E-89 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 Gene3D G3DSA:3.30.465.10 53 164 4.6E-37 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 SUPERFAMILY SSF55447 172 284 6.67E-21 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 173 278 4.2E-12 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 Gene3D G3DSA:3.30.390.50 172 283 8.0E-33 T 17-03-2017 SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 Gene3D G3DSA:3.30.43.10 2 52 8.4E-15 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 SUPERFAMILY SSF56176 2 164 6.54E-51 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 SMART SM01092 171 281 7.3E-20 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS38855 886cd6e0d006286af2bfff78b108fc26 296 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 2 164 2.8E-48 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 Pfam PF07690 Major Facilitator Superfamily 32 426 1.7E-52 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 28 435 1.0E-74 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 Gene3D G3DSA:1.20.1250.20 23 206 1.2E-29 T 17-03-2017 SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 Gene3D G3DSA:1.20.1250.20 283 437 1.1E-22 T 17-03-2017 SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 Gene3D G3DSA:1.20.1250.20 487 513 1.1E-22 T 17-03-2017 SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 SUPERFAMILY SSF103473 486 514 1.01E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 SUPERFAMILY SSF103473 19 216 1.01E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23140 050bd54477ff1d53dadb34798de7eea7 521 SUPERFAMILY SSF103473 265 436 1.01E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS01380 7606a3e8044b8645c6e711049cc517a0 343 SUPERFAMILY SSF144052 138 274 1.26E-7 T 17-03-2017 SHXM_RS01380 7606a3e8044b8645c6e711049cc517a0 343 Gene3D G3DSA:3.40.50.10490 11 65 3.8E-4 T 17-03-2017 SHXM_RS30930 b4d51ee1d0c0bc9f8a2c7a8b00e75115 231 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 18 189 40.102 T 17-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30930 b4d51ee1d0c0bc9f8a2c7a8b00e75115 231 Gene3D G3DSA:3.40.50.700 58 190 3.1E-36 T 17-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30930 b4d51ee1d0c0bc9f8a2c7a8b00e75115 231 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 54 190 6.5E-66 T 17-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30930 b4d51ee1d0c0bc9f8a2c7a8b00e75115 231 SUPERFAMILY SSF56770 54 193 4.97E-61 T 17-03-2017 SHXM_RS30930 b4d51ee1d0c0bc9f8a2c7a8b00e75115 231 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 75 184 1.1E-23 T 17-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS04015 d6fdc32fc70b89684b639e8a171f605b 291 Pfam PF13560 Helix-turn-helix domain 7 85 1.0E-14 T 17-03-2017 SHXM_RS04015 d6fdc32fc70b89684b639e8a171f605b 291 SMART SM00530 10 82 4.9E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS04015 d6fdc32fc70b89684b639e8a171f605b 291 SUPERFAMILY SSF47413 30 77 3.26E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04015 d6fdc32fc70b89684b639e8a171f605b 291 Gene3D G3DSA:1.10.260.40 3 82 4.1E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 SMART SM00387 119 224 7.0E-23 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 Gene3D G3DSA:3.30.565.10 81 224 8.1E-29 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 Gene3D G3DSA:1.10.287.130 3 72 1.4E-5 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 SUPERFAMILY SSF47384 3 76 4.32E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 SMART SM00388 12 77 2.6E-5 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 124 224 2.4E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 PRINTS PR00344 Bacterial sensor protein C-terminal signature 170 180 2.7E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 PRINTS PR00344 Bacterial sensor protein C-terminal signature 187 205 2.7E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 PRINTS PR00344 Bacterial sensor protein C-terminal signature 211 224 2.7E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 PRINTS PR00344 Bacterial sensor protein C-terminal signature 152 166 2.7E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22795 b55e0fbf405945ef1a30276726657a6d 224 SUPERFAMILY SSF55874 81 224 1.05E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 Pfam PF01728 FtsJ-like methyltransferase 65 274 1.1E-15 T 17-03-2017 IPR002877 Ribosomal RNA methyltransferase FtsJ domain GO:0008168|GO:0032259 SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 SMART SM00363 7 74 2.7E-7 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 Gene3D G3DSA:3.40.50.150 124 193 7.2E-10 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 Gene3D G3DSA:3.10.290.10 8 76 2.6E-23 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 Gene3D G3DSA:3.10.290.10 108 123 2.6E-23 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 SUPERFAMILY SSF53335 55 83 1.54E-19 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 SUPERFAMILY SSF53335 113 276 1.54E-19 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 Pfam PF01479 S4 domain 7 51 3.7E-11 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17135 87ad4fe9e7a41e0b4b5b33ae2ff12018 296 SUPERFAMILY SSF55174 7 58 1.77E-11 T 17-03-2017 SHXM_RS25590 f7ce55406699c5aabe8b2d53206e89e3 315 Gene3D G3DSA:1.10.12.10 212 267 6.2E-14 T 17-03-2017 IPR014748 Crontonase, C-terminal SHXM_RS25590 f7ce55406699c5aabe8b2d53206e89e3 315 Pfam PF00378 Enoyl-CoA hydratase/isomerase 29 266 4.4E-44 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS25590 f7ce55406699c5aabe8b2d53206e89e3 315 SUPERFAMILY SSF52096 18 266 1.95E-63 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS25590 f7ce55406699c5aabe8b2d53206e89e3 315 Gene3D G3DSA:3.90.226.10 26 196 1.2E-44 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 SMART SM01209 101 283 2.3E-113 T 17-03-2017 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Gene3D G3DSA:3.30.470.20 179 315 6.0E-56 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Pfam PF01071 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain 101 283 4.0E-64 T 17-03-2017 IPR020561 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 SUPERFAMILY SSF51246 316 415 1.2E-24 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Gene3D G3DSA:3.90.600.10 318 415 5.7E-32 T 17-03-2017 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 SMART SM01210 318 416 6.3E-41 T 17-03-2017 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Gene3D G3DSA:3.40.50.20 2 93 5.0E-32 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 SUPERFAMILY SSF52440 2 101 1.08E-29 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Pfam PF02843 Phosphoribosylglycinamide synthetase, C domain 319 413 5.7E-27 T 17-03-2017 IPR020560 Phosphoribosylglycinamide synthetase, C-domain GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 TIGRFAM TIGR00877 purD: phosphoribosylamine--glycine ligase 2 416 6.0E-144 T 17-03-2017 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Gene3D G3DSA:3.30.1490.20 122 178 1.9E-16 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Hamap MF_00138 Phosphoribosylamine--glycine ligase [purD]. 1 416 40.617 T 17-03-2017 IPR000115 Phosphoribosylglycinamide synthetase GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 Pfam PF02844 Phosphoribosylglycinamide synthetase, N domain 2 100 3.1E-29 T 17-03-2017 IPR020562 Phosphoribosylglycinamide synthetase, N-terminal GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 ProSitePatterns PS00184 Phosphoribosylglycinamide synthetase signature. 277 284 - T 17-03-2017 IPR020559 Phosphoribosylglycinamide synthetase, conserved site GO:0004637|GO:0009113 KEGG: 00230+6.3.4.13|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29340 52b8e9ee3bb0f0e565c2ccb5179dcc00 421 SUPERFAMILY SSF56059 102 306 7.95E-55 T 17-03-2017 SHXM_RS18790 960fe3f8be31238619d7ae85becce208 313 Gene3D G3DSA:3.30.420.40 1 134 5.2E-48 T 17-03-2017 SHXM_RS18790 960fe3f8be31238619d7ae85becce208 313 ProSitePatterns PS01125 ROK family signature. 130 157 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS18790 960fe3f8be31238619d7ae85becce208 313 TIGRFAM TIGR00744 ROK_glcA_fam: ROK family protein (putative glucokinase) 5 311 4.4E-131 T 17-03-2017 IPR004654 Glucokinase ROK GO:0004340|GO:0005737|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 SHXM_RS18790 960fe3f8be31238619d7ae85becce208 313 SUPERFAMILY SSF53067 2 312 4.59E-70 T 17-03-2017 SHXM_RS18790 960fe3f8be31238619d7ae85becce208 313 Pfam PF00480 ROK family 4 312 7.1E-102 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS18790 960fe3f8be31238619d7ae85becce208 313 Gene3D G3DSA:3.30.420.40 135 286 2.5E-53 T 17-03-2017 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 SUPERFAMILY SSF54373 229 323 8.44E-8 T 17-03-2017 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 SUPERFAMILY SSF51905 13 228 7.77E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 SUPERFAMILY SSF51905 324 367 7.77E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 Pfam PF04324 BFD-like [2Fe-2S] binding domain 409 460 7.1E-12 T 17-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 Pfam PF01266 FAD dependent oxidoreductase 14 360 3.3E-60 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 Gene3D G3DSA:3.30.9.10 218 321 1.4E-7 T 17-03-2017 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 Gene3D G3DSA:3.50.50.60 13 93 1.3E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 Gene3D G3DSA:3.50.50.60 325 367 1.3E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49610 c598bf36863520698d38cea040ab2dac 479 Gene3D G3DSA:3.50.50.60 147 217 1.3E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS00435 6162371227c65725b8494afffad1fe1c 430 ProSitePatterns PS01007 Transposases, Mutator family, signature. 256 280 - T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS00435 6162371227c65725b8494afffad1fe1c 430 Pfam PF00872 Transposase, Mutator family 40 397 1.9E-126 T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 SUPERFAMILY SSF82114 178 313 4.58E-43 T 17-03-2017 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 Reactome: R-HSA-196843 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 SUPERFAMILY SSF52374 16 179 1.04E-33 T 17-03-2017 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 Pfam PF01687 Riboflavin kinase 188 310 9.9E-34 T 17-03-2017 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 Reactome: R-HSA-196843 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 TIGRFAM TIGR00083 ribF: riboflavin biosynthesis protein RibF 19 311 2.2E-65 T 17-03-2017 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 SMART SM00904 187 312 7.0E-51 T 17-03-2017 IPR015865 Riboflavin kinase domain, bacterial/eukaryotic GO:0008531|GO:0009231 Reactome: R-HSA-196843 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 Gene3D G3DSA:3.40.50.620 3 183 2.7E-62 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 PIRSF PIRSF004491 2 318 3.2E-97 T 17-03-2017 IPR002606 Riboflavin kinase, bacterial GO:0003919|GO:0008531|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 Pfam PF06574 FAD synthetase 15 159 7.6E-50 T 17-03-2017 IPR015864 FAD synthetase GO:0003919|GO:0009231 KEGG: 00740+2.7.1.26+2.7.7.2|MetaCyc: PWY-5523|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS36945 caee7b8677fa26585fc1ce4e79071dd0 318 Gene3D G3DSA:2.40.30.30 184 314 1.4E-45 T 17-03-2017 IPR023465 Riboflavin kinase domain GO:0008531|GO:0009231 Reactome: R-HSA-196843 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 TIGRFAM TIGR02109 PQQ_syn_pqqE: coenzyme PQQ biosynthesis enzyme PqqE 5 342 1.8E-153 T 17-03-2017 IPR011843 Coenzyme PQQ biosynthesis protein E, bacteria GO:0018189|GO:0051539 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 PIRSF PIRSF037420 1 348 7.8E-100 T 17-03-2017 IPR017200 Coenzyme PQQ synthesis protein E SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 Hamap MF_00660 Coenzyme PQQ synthesis protein E [pqqE]. 1 368 156.359 T 17-03-2017 IPR011843 Coenzyme PQQ biosynthesis protein E, bacteria GO:0018189|GO:0051539 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 Pfam PF04055 Radical SAM superfamily 14 164 4.6E-23 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 Pfam PF13186 Iron-sulfur cluster-binding domain 237 302 2.4E-6 T 17-03-2017 IPR023885 4Fe4S-binding SPASM domain SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 TIGRFAM TIGR04085 rSAM_more_4Fe4S: radical SAM additional 4Fe4S-binding SPASM domain 244 330 1.3E-8 T 17-03-2017 IPR023885 4Fe4S-binding SPASM domain SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 Gene3D G3DSA:3.20.20.70 6 321 6.9E-65 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 SMART SM00729 8 208 2.2E-4 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 SUPERFAMILY SSF102114 7 312 5.36E-66 T 17-03-2017 SHXM_RS07460 70c3672b68dcce514a7c92d376957b72 368 Pfam PF13353 4Fe-4S single cluster domain 15 97 3.8E-6 T 17-03-2017 SHXM_RS24820 3f9cc6eb03c4eadc2a1145481e64dee6 388 Hamap MF_00540 Adenosine deaminase [add]. 12 357 55.59 T 17-03-2017 IPR028893 Adenosine deaminase GO:0004000|GO:0009168 KEGG: 00230+3.5.4.4|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-74217 SHXM_RS24820 3f9cc6eb03c4eadc2a1145481e64dee6 388 Pfam PF00962 Adenosine/AMP deaminase 17 354 1.4E-86 T 17-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 SHXM_RS24820 3f9cc6eb03c4eadc2a1145481e64dee6 388 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 18 354 5.7E-72 T 17-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 SHXM_RS24820 3f9cc6eb03c4eadc2a1145481e64dee6 388 Gene3D G3DSA:3.20.20.140 14 356 1.3E-103 T 17-03-2017 SHXM_RS24820 3f9cc6eb03c4eadc2a1145481e64dee6 388 SUPERFAMILY SSF51556 13 350 5.9E-71 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS23355 bceeb537b0e5a4d79bbfcb8f0dcc4c9a 100 SUPERFAMILY SSF50129 2 85 1.79E-16 T 17-03-2017 IPR011032 GroES-like SHXM_RS23355 bceeb537b0e5a4d79bbfcb8f0dcc4c9a 100 Gene3D G3DSA:2.30.33.40 1 84 2.4E-18 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS23355 bceeb537b0e5a4d79bbfcb8f0dcc4c9a 100 Pfam PF00166 Chaperonin 10 Kd subunit 1 84 7.5E-18 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS23355 bceeb537b0e5a4d79bbfcb8f0dcc4c9a 100 SMART SM00883 1 85 3.2E-20 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 Gene3D G3DSA:3.40.50.720 3 252 1.3E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 3.7E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 3.7E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 3.7E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 SUPERFAMILY SSF51735 4 253 5.39E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 7.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 215 235 7.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 7.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 7.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 7.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 7.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS04570 c4c83d9de27d8ae54275d500fc51cd3e 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 252 3.8E-58 T 17-03-2017 SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 233 2.1E-44 T 17-03-2017 SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 Gene3D G3DSA:3.40.50.720 5 235 1.9E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 8.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 73 84 8.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 126 134 8.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 SUPERFAMILY SSF51735 6 235 2.17E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.5E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 5.5E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 73 84 5.5E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 199 219 5.5E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 5.5E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44075 560be567a62c32b6225a568520db33bf 237 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 120 136 5.5E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 SUPERFAMILY SSF55874 693 835 2.06E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Pfam PF02702 Osmosensitive K+ channel His kinase sensor domain 3 211 8.3E-95 T 17-03-2017 IPR003852 Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal GO:0000155|GO:0000160|GO:0004673|GO:0016020 SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 SUPERFAMILY SSF47384 626 703 6.28E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Pfam PF00582 Universal stress protein family 231 355 7.6E-9 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Gene3D G3DSA:1.10.287.130 628 689 5.2E-6 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Gene3D G3DSA:3.40.50.620 227 355 8.4E-12 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Pfam PF13493 Domain of unknown function (DUF4118) 387 490 1.1E-20 T 17-03-2017 IPR025201 Sensor protein KdpD, transmembrane domain SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Gene3D G3DSA:3.30.565.10 690 788 4.0E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 SUPERFAMILY SSF52402 232 355 1.14E-9 T 17-03-2017 SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Gene3D G3DSA:3.40.50.300 2 210 4.5E-95 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28920 0182adca3e8425352f8f6a36c04f32a1 842 Gene3D G3DSA:1.20.120.620 381 483 6.8E-16 T 17-03-2017 SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 Pfam PF01614 Bacterial transcriptional regulator 142 262 1.0E-23 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 Pfam PF09339 IclR helix-turn-helix domain 30 77 2.8E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 SUPERFAMILY SSF55781 82 264 2.22E-44 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 Gene3D G3DSA:3.30.450.40 101 264 1.1E-46 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 SMART SM00346 24 114 9.5E-22 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 Gene3D G3DSA:1.10.10.10 13 85 2.3E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38270 8ad6f4e6e56eab03e4ba975cff432d16 279 SUPERFAMILY SSF46785 28 94 6.04E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 SUPERFAMILY SSF54980 137 199 2.12E-16 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 SUPERFAMILY SSF54211 3 130 1.25E-40 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 Pfam PF01205 Uncharacterized protein family UPF0029 20 124 1.4E-28 T 17-03-2017 IPR001498 Impact, N-terminal SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 Gene3D G3DSA:3.30.230.30 5 131 2.0E-44 T 17-03-2017 IPR001498 Impact, N-terminal SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 ProSitePatterns PS00910 Uncharacterized protein family UPF0029 signature. 79 108 - T 17-03-2017 IPR020569 Uncharacterised protein family UPF0029, Impact, conserved site SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 Gene3D G3DSA:3.30.70.240 138 206 1.2E-13 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 TIGRFAM TIGR00257 IMPACT_YIGZ: uncharacterized protein, YigZ family 1 200 2.3E-57 T 17-03-2017 IPR015796 Impact family, bacterial/archaeal SHXM_RS08705 a5ec27b444e3155869257a5246f87925 208 Pfam PF09186 Domain of unknown function (DUF1949) 140 194 5.7E-15 T 17-03-2017 IPR015269 Uncharacterised domain UPF0029, Impact, C-terminal SHXM_RS48325 40661dd1d1e3d29fb88ec369309b564c 280 Gene3D G3DSA:3.20.20.70 1 275 1.6E-87 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48325 40661dd1d1e3d29fb88ec369309b564c 280 PIRSF PIRSF001359 1 278 1.1E-75 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS48325 40661dd1d1e3d29fb88ec369309b564c 280 TIGRFAM TIGR00167 cbbA: ketose-bisphosphate aldolase 4 270 1.7E-71 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS48325 40661dd1d1e3d29fb88ec369309b564c 280 SUPERFAMILY SSF51569 2 275 6.15E-81 T 17-03-2017 SHXM_RS48325 40661dd1d1e3d29fb88ec369309b564c 280 Pfam PF01116 Fructose-bisphosphate aldolase class-II 7 275 1.5E-82 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS45940 4f183658e2afc2b29158f89871f8dd77 296 Pfam PF03988 Repeat of Unknown Function (DUF347) 223 278 3.1E-15 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS45940 4f183658e2afc2b29158f89871f8dd77 296 Pfam PF03988 Repeat of Unknown Function (DUF347) 84 152 4.1E-15 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS45940 4f183658e2afc2b29158f89871f8dd77 296 Pfam PF03988 Repeat of Unknown Function (DUF347) 168 214 2.0E-15 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS45940 4f183658e2afc2b29158f89871f8dd77 296 Pfam PF03988 Repeat of Unknown Function (DUF347) 29 80 4.4E-16 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 73 88 1.0E-22 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 88 103 1.0E-22 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 38 53 1.0E-22 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 60 71 1.0E-22 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 Gene3D G3DSA:1.10.10.10 17 115 2.6E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 Pfam PF01022 Bacterial regulatory protein, arsR family 43 90 2.7E-16 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 ProSitePatterns PS00846 Bacterial regulatory proteins, arsR family signature. 62 80 - T 17-03-2017 IPR018334 ArsR-type transcription regulator, HTH motif GO:0003700|GO:0005622|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 SMART SM00418 36 116 2.4E-28 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS32485 cfcd40cf1d253ef01c525af2d45a7905 133 SUPERFAMILY SSF46785 21 116 1.64E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 SUPERFAMILY SSF53067 258 501 7.12E-80 T 17-03-2017 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 SUPERFAMILY SSF53067 8 258 3.89E-92 T 17-03-2017 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 Hamap MF_00186 Glycerol kinase [glpK]. 6 501 54.884 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 PIRSF PIRSF000538 6 506 1.8E-165 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 Gene3D G3DSA:3.30.420.40 258 502 2.4E-97 T 17-03-2017 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 8 255 7.3E-78 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 Gene3D G3DSA:3.30.420.40 6 256 5.8E-104 T 17-03-2017 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 8 500 6.7E-217 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 366 386 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS43810 ba02037605f415b44b5fe5b6c299c231 510 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 264 454 7.7E-63 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS27955 c5c1d65e82fdd72d7d0eeede6a0b5ad7 226 Gene3D G3DSA:1.10.357.10 72 225 2.7E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS27955 c5c1d65e82fdd72d7d0eeede6a0b5ad7 226 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 67 2.8E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27955 c5c1d65e82fdd72d7d0eeede6a0b5ad7 226 Gene3D G3DSA:1.10.10.60 6 71 2.3E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS27955 c5c1d65e82fdd72d7d0eeede6a0b5ad7 226 SUPERFAMILY SSF48498 82 225 2.22E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS27955 c5c1d65e82fdd72d7d0eeede6a0b5ad7 226 SUPERFAMILY SSF46689 12 78 4.62E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS27955 c5c1d65e82fdd72d7d0eeede6a0b5ad7 226 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 81 223 1.6E-19 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS17900 bd33f68a5edbecd43e28fd66a9017494 412 Pfam PF05977 Transmembrane secretion effector 20 402 7.8E-27 T 17-03-2017 IPR010290 Transmembrane secretion effector SHXM_RS17900 bd33f68a5edbecd43e28fd66a9017494 412 Gene3D G3DSA:1.20.1250.20 26 210 5.0E-13 T 17-03-2017 SHXM_RS17900 bd33f68a5edbecd43e28fd66a9017494 412 Gene3D G3DSA:1.20.1250.20 229 403 8.0E-18 T 17-03-2017 SHXM_RS17900 bd33f68a5edbecd43e28fd66a9017494 412 SUPERFAMILY SSF103473 24 404 3.01E-42 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 Gene3D G3DSA:2.40.110.10 121 225 2.4E-35 T 17-03-2017 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 341 360 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 Gene3D G3DSA:1.20.140.10 226 382 5.5E-64 T 17-03-2017 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 124 136 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 122 222 4.1E-22 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 235 382 4.9E-48 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 Gene3D G3DSA:1.10.540.10 2 118 8.0E-43 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 118 1.6E-37 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 SUPERFAMILY SSF56645 2 247 5.89E-79 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS22620 b04ada120c5efaa1b72a490cabbce01b 386 SUPERFAMILY SSF47203 233 382 1.77E-49 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 Gene3D G3DSA:3.30.565.10 209 381 2.4E-46 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 SMART SM00387 267 383 1.3E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 SMART SM00388 156 222 1.2E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 269 382 5.1E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 Pfam PF00512 His Kinase A (phospho-acceptor) domain 157 220 1.0E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 SUPERFAMILY SSF47384 139 222 1.82E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 SUPERFAMILY SSF55874 212 380 4.45E-45 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 Gene3D G3DSA:1.10.287.130 148 208 2.3E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 PRINTS PR00344 Bacterial sensor protein C-terminal signature 343 361 1.2E-20 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 PRINTS PR00344 Bacterial sensor protein C-terminal signature 326 336 1.2E-20 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 PRINTS PR00344 Bacterial sensor protein C-terminal signature 308 322 1.2E-20 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26045 a32e94dda6fdc626b75ebb69f11d2e78 432 PRINTS PR00344 Bacterial sensor protein C-terminal signature 367 380 1.2E-20 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 SUPERFAMILY SSF47413 8 64 6.75E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 SMART SM00354 9 79 4.9E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 ProSitePatterns PS00356 LacI-type HTH domain signature. 12 30 - T 17-03-2017 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 11 21 4.4E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 21 31 4.4E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 SUPERFAMILY SSF53822 69 333 1.23E-52 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 Gene3D G3DSA:3.40.50.2300 58 175 4.9E-28 T 17-03-2017 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 Gene3D G3DSA:3.40.50.2300 176 316 2.3E-40 T 17-03-2017 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 Pfam PF13377 Periplasmic binding protein-like domain 173 334 1.5E-34 T 17-03-2017 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 Gene3D G3DSA:1.10.260.40 8 57 2.4E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41390 c05dffefb727dccc410f85617eaa8ea0 334 Pfam PF00356 Bacterial regulatory proteins, lacI family 11 56 1.5E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 Gene3D G3DSA:3.30.450.20 37 135 7.4E-9 T 17-03-2017 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 SUPERFAMILY SSF46894 144 214 1.53E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 153 167 5.4E-5 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 183 5.4E-5 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 195 5.4E-5 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 Pfam PF08448 PAS fold 32 124 1.7E-7 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 Pfam PF00196 Bacterial regulatory proteins, luxR family 152 206 9.1E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 SUPERFAMILY SSF55785 30 129 2.23E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 Gene3D G3DSA:1.10.10.10 147 211 3.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44900 da19ac92d8d7a8971f9e19d6700445c7 228 SMART SM00421 150 207 2.6E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24770 099c4c6ebb4d7a2f652313f4e628393e 306 Gene3D G3DSA:3.20.20.140 7 301 1.1E-101 T 17-03-2017 SHXM_RS24770 099c4c6ebb4d7a2f652313f4e628393e 306 Pfam PF04909 Amidohydrolase 30 300 5.5E-47 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS24770 099c4c6ebb4d7a2f652313f4e628393e 306 SUPERFAMILY SSF51556 25 300 2.88E-77 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS16680 33cbf6fdc6ce0d2dd782cdde22a20199 317 Gene3D G3DSA:3.40.50.1820 44 316 1.5E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16680 33cbf6fdc6ce0d2dd782cdde22a20199 317 SMART SM00824 Thioesterase 97 313 5.4E-65 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS16680 33cbf6fdc6ce0d2dd782cdde22a20199 317 SUPERFAMILY SSF53474 4 23 1.27E-30 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16680 33cbf6fdc6ce0d2dd782cdde22a20199 317 SUPERFAMILY SSF53474 71 314 1.27E-30 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16680 33cbf6fdc6ce0d2dd782cdde22a20199 317 Pfam PF00975 Thioesterase domain 96 312 1.3E-16 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS23760 a4349d7fda8a00595d45def38f34d0f4 438 Pfam PF07690 Major Facilitator Superfamily 63 301 2.9E-8 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23760 a4349d7fda8a00595d45def38f34d0f4 438 Gene3D G3DSA:1.20.1250.20 48 231 8.2E-8 T 17-03-2017 SHXM_RS23760 a4349d7fda8a00595d45def38f34d0f4 438 SUPERFAMILY SSF103473 32 417 8.76E-28 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23760 a4349d7fda8a00595d45def38f34d0f4 438 Gene3D G3DSA:1.20.1250.20 246 415 9.7E-7 T 17-03-2017 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 Gene3D G3DSA:3.50.50.60 177 199 4.1E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 SMART SM01003 4 137 1.1E-79 T 17-03-2017 IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 Gene3D G3DSA:3.40.50.1770 200 357 2.8E-29 T 17-03-2017 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 Pfam PF05222 Alanine dehydrogenase/PNT, N-terminal domain 4 137 2.2E-48 T 17-03-2017 IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 Pfam PF01262 Alanine dehydrogenase/PNT, C-terminal domain 141 352 1.2E-80 T 17-03-2017 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 SUPERFAMILY SSF51735 137 303 3.48E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 SMART SM01002 149 297 1.4E-82 T 17-03-2017 IPR007698 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 Gene3D G3DSA:3.40.50.1770 2 176 1.5E-57 T 17-03-2017 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 ProSitePatterns PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1. 4 30 - T 17-03-2017 IPR008142 Alanine dehydrogenase/NAD(P) transhydrogenase, conserved site-1 GO:0016491|GO:0055114 Reactome: R-HSA-71403 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 TIGRFAM TIGR00518 alaDH: alanine dehydrogenase 2 359 9.7E-174 T 17-03-2017 IPR008141 Alanine dehydrogenase GO:0000286|GO:0042853 KEGG: 00250+1.4.1.1|KEGG: 00430+1.4.1.1 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 SUPERFAMILY SSF52283 305 360 2.98E-66 T 17-03-2017 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 SUPERFAMILY SSF52283 2 137 2.98E-66 T 17-03-2017 SHXM_RS17085 086c5ce23bd32936e65946630e4fe996 371 PIRSF PIRSF000183 1 370 2.8E-166 T 17-03-2017 IPR008141 Alanine dehydrogenase GO:0000286|GO:0042853 KEGG: 00250+1.4.1.1|KEGG: 00430+1.4.1.1 SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 SMART SM00642 21 407 5.4E-116 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 Pfam PF00128 Alpha amylase, catalytic domain 36 381 2.9E-71 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 SUPERFAMILY SSF51445 11 467 1.35E-119 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 Gene3D G3DSA:3.20.20.80 183 468 2.0E-99 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 Gene3D G3DSA:3.20.20.80 10 112 2.0E-99 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 Gene3D G3DSA:3.90.400.10 113 182 4.1E-25 T 17-03-2017 SHXM_RS05440 43459cbe12826fe0c21d102b3ccb9239 532 Pfam PF11941 Domain of unknown function (DUF3459) 453 530 2.9E-6 T 17-03-2017 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) SHXM_RS48890 251620172a7a67781142f09cb77baa3a 367 Pfam PF00083 Sugar (and other) transporter 26 226 9.5E-25 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS48890 251620172a7a67781142f09cb77baa3a 367 SUPERFAMILY SSF103473 17 360 1.57E-51 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS48890 251620172a7a67781142f09cb77baa3a 367 Gene3D G3DSA:1.20.1250.20 250 357 8.5E-10 T 17-03-2017 SHXM_RS48890 251620172a7a67781142f09cb77baa3a 367 Gene3D G3DSA:1.20.1250.20 42 225 1.5E-21 T 17-03-2017 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 Gene3D G3DSA:1.10.730.10 208 358 1.4E-30 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 SUPERFAMILY SSF47323 208 358 7.19E-23 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 SMART SM01016 4 97 8.6E-15 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 SMART SM00836 214 358 2.1E-28 T 17-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 Pfam PF05746 DALR anticodon binding domain 214 358 1.8E-21 T 17-03-2017 IPR008909 DALR anticodon binding GO:0004814|GO:0005524|GO:0006420 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 Pfam PF03485 Arginyl tRNA synthetase N terminal domain 26 97 7.8E-11 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 SUPERFAMILY SSF55190 22 110 7.98E-11 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS35155 0e47e9dd2fd0fc1ad2fe597803baa9bf 358 Gene3D G3DSA:3.30.1360.70 3 114 8.2E-20 T 17-03-2017 IPR005148 Arginyl tRNA synthetase N-terminal domain GO:0000166|GO:0004814|GO:0005524|GO:0005737|GO:0006420 KEGG: 00970+6.1.1.19 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 Pfam PF01084 Ribosomal protein S18 25 75 1.7E-25 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 Hamap MF_00270 30S ribosomal protein S18 [rpsR]. 9 80 20.631 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 Gene3D G3DSA:4.10.640.10 16 77 3.7E-30 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 TIGRFAM TIGR00165 S18: ribosomal protein bS18 13 77 2.2E-24 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 SUPERFAMILY SSF46911 7 78 7.32E-27 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 PRINTS PR00974 Ribosomal protein S18 family signature 53 67 9.5E-18 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 PRINTS PR00974 Ribosomal protein S18 family signature 35 45 9.5E-18 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 PRINTS PR00974 Ribosomal protein S18 family signature 67 77 9.5E-18 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 PRINTS PR00974 Ribosomal protein S18 family signature 45 52 9.5E-18 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 ProDom PD002239 RIBOSOMAL S18 RIBONUCLEOPROTEIN 30S RRNA-BINDING RNA-BINDING CHLOROPLAST PLASTID MITOCHONDRIAL ACETYLATION 27 77 7.0E-21 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05970 255a511ee6e66cf28a0981567a6ad6ef 80 ProSitePatterns PS00057 Ribosomal protein S18 signature. 28 51 - T 17-03-2017 IPR018275 Ribosomal protein S18, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 61 1.3E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 SUPERFAMILY SSF48498 86 189 7.41E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 SUPERFAMILY SSF46689 15 85 1.33E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 Gene3D G3DSA:1.10.357.10 64 197 3.7E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 Gene3D G3DSA:1.10.10.60 15 63 8.1E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 1.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47065 cc102a4867c817057ff77516c5ce8661 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 1.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS24110 23d6206d0765975ac1adea35835eb88e 625 Pfam PF10646 Sporulation and spore germination 203 326 9.2E-5 T 17-03-2017 IPR019606 GerMN domain SHXM_RS24110 23d6206d0765975ac1adea35835eb88e 625 SUPERFAMILY SSF69322 353 600 3.66E-11 T 17-03-2017 SHXM_RS24110 23d6206d0765975ac1adea35835eb88e 625 Gene3D G3DSA:2.130.10.10 381 429 2.8E-8 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS24110 23d6206d0765975ac1adea35835eb88e 625 Gene3D G3DSA:2.130.10.10 477 609 2.8E-8 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS24110 23d6206d0765975ac1adea35835eb88e 625 Pfam PF10647 Lipoprotein LpqB beta-propeller domain 363 624 1.5E-43 T 17-03-2017 IPR018910 Lipoprotein LpqB, beta-propeller domain, C-terminal SHXM_RS24110 23d6206d0765975ac1adea35835eb88e 625 SMART SM00909 235 333 0.0071 T 17-03-2017 IPR019606 GerMN domain SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 Gene3D G3DSA:2.70.98.40 2 269 1.2E-78 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 Gene3D G3DSA:1.50.10.10 316 717 9.4E-125 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 Pfam PF03633 Glycosyl hydrolase family 65, C-terminal domain 742 791 3.1E-8 T 17-03-2017 IPR005194 Glycoside hydrolase family 65, C-terminal SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 Pfam PF03636 Glycosyl hydrolase family 65, N-terminal domain 8 266 1.7E-64 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 PIRSF PIRSF036289 1 802 3.0E-203 T 17-03-2017 IPR017045 Maltose phosphorylase/glycosyl hydrolase/vacuolar acid trehalase SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 SUPERFAMILY SSF48208 273 784 5.99E-98 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 Pfam PF03632 Glycosyl hydrolase family 65 central catalytic domain 319 731 1.7E-144 T 17-03-2017 IPR005195 Glycoside hydrolase, family 65, central catalytic GO:0003824|GO:0005975 SHXM_RS07840 ffc978cfad7a171c404ca0dc17898ab1 804 SUPERFAMILY SSF74650 2 268 3.45E-59 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 301 1.7E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 Gene3D G3DSA:3.50.50.60 4 123 7.7E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 Gene3D G3DSA:3.50.50.60 145 315 6.3E-36 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 233 249 1.8E-18 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 103 121 1.8E-18 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 257 279 1.8E-18 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 1.8E-18 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 147 165 1.8E-18 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 Gene3D G3DSA:3.30.390.30 321 382 8.6E-14 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 234 248 2.0E-17 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 272 279 2.0E-17 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 2.0E-17 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 147 172 2.0E-17 T 17-03-2017 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 Pfam PF14759 Reductase C-terminal 321 382 1.7E-8 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 SUPERFAMILY SSF55424 313 384 1.22E-17 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 SUPERFAMILY SSF51905 194 336 1.41E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41465 952714c7eb836970c4100a06f9df2d9c 390 SUPERFAMILY SSF51905 5 164 1.41E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 Pfam PF00449 Urease alpha-subunit, N-terminal domain 4 126 1.2E-46 T 17-03-2017 IPR011612 Urease alpha-subunit, N-terminal domain KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 SUPERFAMILY SSF51556 136 439 2.56E-182 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 SUPERFAMILY SSF51556 488 573 2.56E-182 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 Gene3D G3DSA:3.20.20.140 495 571 1.9E-189 T 17-03-2017 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 Gene3D G3DSA:3.20.20.140 144 436 1.9E-189 T 17-03-2017 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 Gene3D G3DSA:2.30.40.10 71 143 7.5E-8 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 ProSitePatterns PS00145 Urease active site. 324 340 - T 17-03-2017 IPR017950 Urease active site GO:0009039 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 TIGRFAM TIGR01792 urease_alph: urease, alpha subunit 4 573 1.2E-270 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 Pfam PF01979 Amidohydrolase family 132 460 8.1E-69 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 341 357 2.6E-24 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 302 319 2.6E-24 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 434 447 2.6E-24 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 408 423 2.6E-24 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 Hamap MF_01953 Urease subunit alpha [ureC]. 2 574 53.042 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 ProSitePatterns PS01120 Urease nickel ligands signature. 134 147 - T 17-03-2017 IPR029754 Urease nickel binding site GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35415 c040ec41c73d75234f305a18b86c345f 574 SUPERFAMILY SSF51338 3 184 6.68E-50 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 Gene3D G3DSA:3.40.190.10 179 261 2.3E-10 T 17-03-2017 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 Gene3D G3DSA:3.40.190.10 92 178 8.6E-13 T 17-03-2017 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 2 60 9.5E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 16 27 2.0E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 27 37 2.0E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 37 48 2.0E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 SUPERFAMILY SSF46785 2 103 6.81E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 SUPERFAMILY SSF53850 91 276 1.05E-16 T 17-03-2017 SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 Gene3D G3DSA:1.10.10.10 2 81 1.5E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34710 235dcb74015c051ebfdf3a085e76a876 397 Pfam PF03466 LysR substrate binding domain 89 273 6.2E-20 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 SMART SM00382 281 477 2.7E-4 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 SMART SM00382 30 226 1.0E-5 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 SUPERFAMILY SSF52540 259 485 1.93E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 Pfam PF00005 ABC transporter 21 170 3.2E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 Pfam PF00005 ABC transporter 273 428 1.1E-20 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 SUPERFAMILY SSF52540 4 227 1.43E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 Gene3D G3DSA:3.40.50.300 2 225 6.1E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 Gene3D G3DSA:3.40.50.300 255 483 6.8E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41710 2c94719e572a23fce6ba648f510ff472 514 ProSitePatterns PS00211 ABC transporters family signature. 401 415 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 SUPERFAMILY SSF51735 8 249 2.34E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 Gene3D G3DSA:3.40.50.720 5 249 1.1E-85 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 3.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 85 96 3.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 3.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 9 189 1.2E-4 T 17-03-2017 SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 1.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 1.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 211 231 1.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 1.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 1.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13915 b66330cfbcf93583047d88ddc2d628a0 250 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 246 4.8E-60 T 17-03-2017 SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 Gene3D G3DSA:1.10.10.10 8 142 4.0E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 117 137 1.7E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 68 83 1.7E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 87 103 1.7E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 51 67 1.7E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 Pfam PF01047 MarR family 34 90 1.4E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 SUPERFAMILY SSF46785 7 143 1.63E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20820 614587426c22458cddacd39c8c144e29 146 SMART SM00347 27 127 2.5E-16 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 417 578 6.9E-47 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 Gene3D G3DSA:3.40.50.1220 213 377 6.0E-66 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 SUPERFAMILY SSF52467 210 385 4.04E-62 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 218 353 2.2E-46 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 Gene3D G3DSA:3.40.50.970 27 204 3.1E-70 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 SUPERFAMILY SSF52518 27 207 6.68E-59 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 29 194 6.0E-54 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 Gene3D G3DSA:3.40.50.970 378 594 1.0E-74 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 TIGRFAM TIGR00118 acolac_lg: acetolactate synthase, large subunit, biosynthetic type 29 602 8.0E-229 T 17-03-2017 IPR012846 Acetolactate synthase, large subunit, biosynthetic GO:0000287|GO:0003984|GO:0009082|GO:0030976|GO:0050660 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 SHXM_RS36155 fdb715585fc97bc536da5ea940606a8d 616 SUPERFAMILY SSF52518 394 606 2.5E-66 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS15345 cd01b37b48d7219845abb82d94476611 139 SUPERFAMILY SSF88723 3 121 1.43E-14 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS15345 cd01b37b48d7219845abb82d94476611 139 Pfam PF01850 PIN domain 18 121 7.9E-10 T 17-03-2017 IPR002716 PIN domain SHXM_RS15345 cd01b37b48d7219845abb82d94476611 139 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 5 127 10.499 T 17-03-2017 IPR022907 VapC family GO:0004540 SHXM_RS15345 cd01b37b48d7219845abb82d94476611 139 Gene3D G3DSA:3.40.50.1010 3 120 4.4E-9 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 Gene3D G3DSA:1.10.3810.10 78 254 6.7E-60 T 17-03-2017 SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 Pfam PF00905 Penicillin binding protein transpeptidase domain 433 612 1.3E-17 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 Pfam PF00912 Transglycosylase 80 253 7.9E-55 T 17-03-2017 IPR001264 Glycosyl transferase, family 51 SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 SUPERFAMILY SSF56601 237 257 5.87E-61 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 SUPERFAMILY SSF56601 287 655 5.87E-61 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 SUPERFAMILY SSF53955 66 273 1.07E-62 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS38315 a3a052634fd830729eaa43774df0c501 659 Gene3D G3DSA:3.40.710.10 255 655 4.2E-81 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 Gene3D G3DSA:2.160.20.10 42 393 1.3E-67 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 Pfam PF07602 Protein of unknown function (DUF1565) 54 91 1.5E-4 T 17-03-2017 IPR011459 Domain of unknown function DUF1565 SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 SMART SM00710 159 181 920.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 SMART SM00710 136 158 2100.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 SMART SM00710 217 239 660.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 SMART SM00710 184 214 1300.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 Pfam PF13229 Right handed beta helix region 132 307 1.2E-9 T 17-03-2017 SHXM_RS17630 38592a05596587b4f1482a0104a1e1dd 406 SUPERFAMILY SSF51126 43 353 1.51E-53 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 SUPERFAMILY SSF47741 81 145 1.7E-22 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 3 55 1.0E-4 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 SMART SM01008 167 279 8.3E-48 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 SUPERFAMILY SSF54292 2 86 3.01E-20 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 SUPERFAMILY SSF54665 151 298 1.44E-42 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:1.10.150.120 72 144 2.3E-24 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 SUPERFAMILY SSF56003 282 901 2.36E-173 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.30.365.10 607 750 2.8E-28 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.10.20.30 2 71 3.6E-23 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 167 278 2.3E-26 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.30.365.10 439 512 6.1E-40 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.30.365.10 268 331 6.1E-40 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 36 44 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Pfam PF01799 [2Fe-2S] binding domain 70 138 1.6E-23 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 309 841 5.4E-153 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.30.365.10 756 901 4.8E-56 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.30.365.10 514 606 4.8E-56 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.90.1170.50 145 267 1.3E-39 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS39155 08b2c9bb139297cd0e1168a87aec0a43 924 Gene3D G3DSA:3.30.365.10 332 437 1.4E-39 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS07790 b57443d095a61911fc298f60dbd156ab 255 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 19 242 2.0E-36 T 17-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 SHXM_RS07790 b57443d095a61911fc298f60dbd156ab 255 SUPERFAMILY SSF51621 5 253 2.38E-64 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS07790 b57443d095a61911fc298f60dbd156ab 255 Gene3D G3DSA:3.20.20.60 5 253 3.2E-65 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 SUPERFAMILY SSF51905 1 187 2.74E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 Pfam PF14759 Reductase C-terminal 316 385 2.6E-11 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 Gene3D G3DSA:3.50.50.60 99 237 6.1E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 Gene3D G3DSA:3.30.390.30 316 386 1.8E-16 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 SUPERFAMILY SSF51905 140 306 1.94E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 Gene3D G3DSA:3.50.50.60 1 98 2.8E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 1 295 7.1E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 262 280 5.6E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 138 162 5.6E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 230 251 5.6E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 97 105 5.6E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 228 244 1.1E-13 T 17-03-2017 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 142 160 1.1E-13 T 17-03-2017 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 252 274 1.1E-13 T 17-03-2017 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 96 114 1.1E-13 T 17-03-2017 SHXM_RS03185 5afb7b10c0b857e1e7d35d3c304e1140 406 SUPERFAMILY SSF55424 310 386 2.93E-18 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS42820 27b865e68181417ef851753522308fd6 288 SUPERFAMILY SSF48179 186 285 1.62E-27 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS42820 27b865e68181417ef851753522308fd6 288 Gene3D G3DSA:1.10.1040.10 189 283 1.1E-27 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS42820 27b865e68181417ef851753522308fd6 288 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 187 283 1.9E-28 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS42820 27b865e68181417ef851753522308fd6 288 Gene3D G3DSA:3.40.50.720 9 188 6.5E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42820 27b865e68181417ef851753522308fd6 288 PIRSF PIRSF000105 4 288 2.2E-80 T 17-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SHXM_RS42820 27b865e68181417ef851753522308fd6 288 SUPERFAMILY SSF51735 9 186 1.06E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42820 27b865e68181417ef851753522308fd6 288 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 10 184 4.1E-47 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS48420 fc503684519b91c73a4fb862da166018 359 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 149 356 1.0E-39 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48420 fc503684519b91c73a4fb862da166018 359 Gene3D G3DSA:1.10.3720.10 126 346 1.4E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48420 fc503684519b91c73a4fb862da166018 359 SUPERFAMILY SSF161098 125 344 4.74E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25410 90d69c48ba31b70bda3b232563c46c68 265 Gene3D G3DSA:3.40.225.10 30 240 1.5E-62 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS25410 90d69c48ba31b70bda3b232563c46c68 265 SMART SM01007 36 216 6.3E-51 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS25410 90d69c48ba31b70bda3b232563c46c68 265 SUPERFAMILY SSF53639 29 247 2.94E-62 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS25410 90d69c48ba31b70bda3b232563c46c68 265 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 37 216 1.5E-45 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 Pfam PF01494 FAD binding domain 1 361 1.7E-67 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 296 311 7.5E-42 T 17-03-2017 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 2 24 7.5E-42 T 17-03-2017 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 311 327 7.5E-42 T 17-03-2017 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 329 347 7.5E-42 T 17-03-2017 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 174 189 7.5E-42 T 17-03-2017 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 347 363 7.5E-42 T 17-03-2017 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 Gene3D G3DSA:3.50.50.60 2 57 6.0E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 Gene3D G3DSA:3.50.50.60 113 200 6.0E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 Gene3D G3DSA:3.50.50.60 284 364 6.0E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 SUPERFAMILY SSF51905 116 195 2.16E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 SUPERFAMILY SSF51905 283 372 2.16E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11820 0849e925e54f182ad57fd313e48698f9 524 SUPERFAMILY SSF51905 1 68 2.16E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45725 675229630328921f0388d5c534060e67 289 ProSitePatterns PS00211 ABC transporters family signature. 162 176 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS45725 675229630328921f0388d5c534060e67 289 SUPERFAMILY SSF52540 16 261 2.13E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45725 675229630328921f0388d5c534060e67 289 SMART SM00382 48 239 1.5E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45725 675229630328921f0388d5c534060e67 289 Gene3D G3DSA:3.40.50.300 15 262 1.1E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45725 675229630328921f0388d5c534060e67 289 Pfam PF00005 ABC transporter 39 189 1.9E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS06965 4202683a0f1d0f7b61804f3f38987fae 150 SUPERFAMILY SSF52091 17 110 1.43E-10 T 17-03-2017 IPR002645 STAS domain SHXM_RS06965 4202683a0f1d0f7b61804f3f38987fae 150 Gene3D G3DSA:3.30.750.24 19 108 1.4E-8 T 17-03-2017 IPR002645 STAS domain SHXM_RS06965 4202683a0f1d0f7b61804f3f38987fae 150 Pfam PF13466 STAS domain 22 103 2.2E-16 T 17-03-2017 IPR002645 STAS domain SHXM_RS00810 110a47db38f0dd83b82516c691775255 321 Gene3D G3DSA:1.10.10.10 3 62 4.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00810 110a47db38f0dd83b82516c691775255 321 Pfam PF13280 WYL domain 143 313 2.3E-32 T 17-03-2017 IPR026881 WYL domain SHXM_RS00810 110a47db38f0dd83b82516c691775255 321 Pfam PF08279 HTH domain 5 58 2.5E-16 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS00810 110a47db38f0dd83b82516c691775255 321 SUPERFAMILY SSF46785 4 58 3.48E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Gene3D G3DSA:1.10.1040.10 191 324 4.2E-8 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Pfam PF02558 Ketopantoate reductase PanE/ApbA 12 158 2.2E-26 T 17-03-2017 IPR013332 Ketopantoate reductase, N-terminal domain GO:0008677|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Gene3D G3DSA:3.40.50.720 11 190 7.9E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 SUPERFAMILY SSF51735 12 151 1.68E-15 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Pfam PF07687 Peptidase dimerisation domain 541 634 4.7E-16 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 SUPERFAMILY SSF55031 544 635 1.94E-17 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 SUPERFAMILY SSF53187 357 553 2.0E-39 T 17-03-2017 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 SUPERFAMILY SSF53187 663 738 2.0E-39 T 17-03-2017 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Gene3D G3DSA:3.30.70.360 545 638 3.0E-20 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Pfam PF08546 Ketopantoate reductase PanE/ApbA C terminal 184 323 6.4E-5 T 17-03-2017 IPR013752 Ketopantoate reductase, C-terminal domain GO:0016491|GO:0050661|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Gene3D G3DSA:3.40.630.10 355 544 4.9E-40 T 17-03-2017 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Gene3D G3DSA:3.40.630.10 652 738 4.9E-40 T 17-03-2017 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 Pfam PF01546 Peptidase family M20/M25/M40 441 734 8.4E-21 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS41025 7929cf85f47be55305eba9c36c1ea93e 740 SUPERFAMILY SSF48179 184 324 1.39E-6 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS01955 324b345c6f6b3b5f0e24ca427198b411 391 Gene3D G3DSA:3.40.640.10 59 264 4.7E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS01955 324b345c6f6b3b5f0e24ca427198b411 391 Gene3D G3DSA:3.90.1150.10 265 386 2.2E-5 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS01955 324b345c6f6b3b5f0e24ca427198b411 391 SUPERFAMILY SSF53383 25 386 5.15E-82 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS01955 324b345c6f6b3b5f0e24ca427198b411 391 Pfam PF00155 Aminotransferase class I and II 30 324 2.1E-28 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 146 456 4.1E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 Gene3D G3DSA:3.50.50.60 235 399 1.1E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 SUPERFAMILY SSF46548 6 155 1.41E-35 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 Gene3D G3DSA:3.40.50.720 148 234 5.3E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 Gene3D G3DSA:3.40.50.720 400 481 5.3E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 PRINTS PR00419 Adrenodoxin reductase family signature 285 299 8.2E-25 T 17-03-2017 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 PRINTS PR00419 Adrenodoxin reductase family signature 146 168 8.2E-25 T 17-03-2017 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 PRINTS PR00419 Adrenodoxin reductase family signature 169 182 8.2E-25 T 17-03-2017 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 PRINTS PR00419 Adrenodoxin reductase family signature 211 221 8.2E-25 T 17-03-2017 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 TIGRFAM TIGR01317 GOGAT_sm_gam: glutamate synthase, NADH/NADPH, small subunit 3 474 1.8E-210 T 17-03-2017 IPR006005 Glutamate synthase, NADH/NADPH, small subunit 1 GO:0006537|GO:0016639|GO:0055114 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 SUPERFAMILY SSF51971 144 400 7.06E-66 T 17-03-2017 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 Pfam PF14691 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster 40 130 3.4E-20 T 17-03-2017 IPR028261 Dihydroprymidine dehydrogenase domain II Reactome: R-HSA-73621 SHXM_RS18280 7864d7d46d6c920db47ea71f711fb321 486 Gene3D G3DSA:1.10.1060.10 2 147 5.7E-36 T 17-03-2017 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 SUPERFAMILY SSF63737 62 253 1.18E-36 T 17-03-2017 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 336 351 5.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 237 252 5.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 355 367 5.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 190 205 5.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 Gene3D G3DSA:1.10.390.10 350 485 2.1E-24 T 17-03-2017 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 SUPERFAMILY SSF55486 261 485 4.83E-53 T 17-03-2017 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 Pfam PF01433 Peptidase family M1 76 305 3.8E-24 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS33760 3c77ac9fd076ad66711bcbc1210998e9 488 Pfam PF01433 Peptidase family M1 334 378 7.4E-18 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS45775 45b2416766e8d054c4f2bfbf6fc2fb22 131 Gene3D G3DSA:3.10.129.10 6 128 8.2E-17 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45775 45b2416766e8d054c4f2bfbf6fc2fb22 131 Pfam PF01575 MaoC like domain 16 101 5.2E-6 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS45775 45b2416766e8d054c4f2bfbf6fc2fb22 131 SUPERFAMILY SSF54637 7 127 4.83E-17 T 17-03-2017 IPR029069 HotDog domain SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 SMART SM00420 6 58 2.5E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 Gene3D G3DSA:1.10.10.10 2 56 1.5E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 Pfam PF00455 DeoR C terminal sensor domain 75 241 1.8E-48 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 9.1E-8 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 9.1E-8 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 SMART SM01134 72 242 5.3E-62 T 17-03-2017 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 SUPERFAMILY SSF100950 76 243 1.57E-28 T 17-03-2017 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 SUPERFAMILY SSF46785 4 64 2.63E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 3.6E-16 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS06945 13541786f8e8bccb43e18e677808f073 261 Gene3D G3DSA:3.40.50.1360 76 227 1.4E-18 T 17-03-2017 SHXM_RS00495 4d3445d12f4bef0e7d782134381510e0 197 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 16 168 2.0E-28 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS00495 4d3445d12f4bef0e7d782134381510e0 197 SUPERFAMILY SSF53254 16 169 6.28E-33 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS00495 4d3445d12f4bef0e7d782134381510e0 197 Gene3D G3DSA:3.40.50.1240 15 168 3.7E-32 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS00495 4d3445d12f4bef0e7d782134381510e0 197 SMART SM00855 10 156 4.8E-4 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS18895 f041b6c0bea41ae7a9a26760acffd40a 415 Pfam PF03734 L,D-transpeptidase catalytic domain 250 365 5.2E-12 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS18895 f041b6c0bea41ae7a9a26760acffd40a 415 Gene3D G3DSA:2.40.440.10 249 366 5.7E-17 T 17-03-2017 SHXM_RS18895 f041b6c0bea41ae7a9a26760acffd40a 415 SUPERFAMILY SSF141523 244 365 5.36E-26 T 17-03-2017 SHXM_RS47490 a0f12274f02549b7364c17725d22949d 498 Pfam PF07690 Major Facilitator Superfamily 28 422 1.7E-40 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS47490 a0f12274f02549b7364c17725d22949d 498 SUPERFAMILY SSF103473 265 469 4.05E-50 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47490 a0f12274f02549b7364c17725d22949d 498 SUPERFAMILY SSF103473 15 210 4.05E-50 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47490 a0f12274f02549b7364c17725d22949d 498 Gene3D G3DSA:1.20.1250.20 19 206 1.7E-23 T 17-03-2017 SHXM_RS47490 a0f12274f02549b7364c17725d22949d 498 Gene3D G3DSA:1.20.1250.20 292 472 4.4E-14 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 Gene3D G3DSA:3.40.50.980 189 210 8.4E-34 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 Gene3D G3DSA:3.40.50.980 14 157 8.4E-34 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 ProSitePatterns PS00455 Putative AMP-binding domain signature. 204 215 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 Pfam PF00501 AMP-binding enzyme 21 493 3.3E-92 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 SUPERFAMILY SSF56801 9 307 2.62E-114 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 SUPERFAMILY SSF56801 364 624 2.62E-114 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 Gene3D G3DSA:2.30.38.10 423 484 1.2E-18 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 Gene3D G3DSA:3.40.50.980 361 422 1.1E-23 T 17-03-2017 SHXM_RS21320 8fd86cd98f867dcfe72b16a2a2179525 629 Gene3D G3DSA:3.40.50.980 211 302 1.1E-23 T 17-03-2017 SHXM_RS47135 6511e3edeab3ba8431a605af0ed46846 288 SUPERFAMILY SSF100950 4 275 8.9E-72 T 17-03-2017 SHXM_RS47135 6511e3edeab3ba8431a605af0ed46846 288 SMART SM00882 6 228 6.8E-34 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS47135 6511e3edeab3ba8431a605af0ed46846 288 Pfam PF01144 Coenzyme A transferase 7 227 2.9E-38 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS47135 6511e3edeab3ba8431a605af0ed46846 288 Gene3D G3DSA:3.40.1080.10 4 118 1.8E-76 T 17-03-2017 SHXM_RS47135 6511e3edeab3ba8431a605af0ed46846 288 Gene3D G3DSA:3.40.1080.10 157 281 1.8E-76 T 17-03-2017 SHXM_RS11495 ae3b8f0bce657e308f81fb2aaed30df9 140 Pfam PF12796 Ankyrin repeats (3 copies) 27 112 1.6E-10 T 17-03-2017 IPR020683 Ankyrin repeat-containing domain SHXM_RS11495 ae3b8f0bce657e308f81fb2aaed30df9 140 SMART SM00248 51 80 2.0E-4 T 17-03-2017 IPR002110 Ankyrin repeat GO:0005515 SHXM_RS11495 ae3b8f0bce657e308f81fb2aaed30df9 140 SMART SM00248 84 113 0.83 T 17-03-2017 IPR002110 Ankyrin repeat GO:0005515 SHXM_RS11495 ae3b8f0bce657e308f81fb2aaed30df9 140 SUPERFAMILY SSF48403 26 134 6.06E-21 T 17-03-2017 IPR020683 Ankyrin repeat-containing domain SHXM_RS11495 ae3b8f0bce657e308f81fb2aaed30df9 140 Gene3D G3DSA:1.25.40.20 26 136 2.6E-21 T 17-03-2017 IPR020683 Ankyrin repeat-containing domain SHXM_RS45840 0d3edfc3318f49f68fcf6b19e3a88565 266 SUPERFAMILY SSF53474 5 263 1.02E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45840 0d3edfc3318f49f68fcf6b19e3a88565 266 Pfam PF12697 Alpha/beta hydrolase family 28 255 6.4E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45840 0d3edfc3318f49f68fcf6b19e3a88565 266 Gene3D G3DSA:3.40.50.1820 6 262 1.7E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45840 0d3edfc3318f49f68fcf6b19e3a88565 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 51 66 1.8E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45840 0d3edfc3318f49f68fcf6b19e3a88565 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 95 108 1.8E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45840 0d3edfc3318f49f68fcf6b19e3a88565 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 109 122 1.8E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 Pfam PF00754 F5/8 type C domain 451 570 1.3E-13 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 SMART SM00812 30 393 0.0046 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 Gene3D G3DSA:2.60.120.260 430 570 2.4E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 Pfam PF01120 Alpha-L-fucosidase 76 242 3.2E-9 T 17-03-2017 IPR000933 Glycoside hydrolase, family 29 GO:0004560|GO:0005975 KEGG: 00511+3.2.1.51 SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 Gene3D G3DSA:3.20.20.80 36 323 4.6E-24 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 SUPERFAMILY SSF49785 441 569 3.9E-19 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS07485 e1f9fd2b7561b0b18fb52cfa52012714 597 SUPERFAMILY SSF51445 36 281 1.73E-21 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS13215 9ae12cc6bf369209504054002b49253a 230 SUPERFAMILY SSF52317 31 228 1.23E-41 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS13215 9ae12cc6bf369209504054002b49253a 230 Gene3D G3DSA:3.40.50.880 3 214 4.0E-47 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS13215 9ae12cc6bf369209504054002b49253a 230 Pfam PF07722 Peptidase C26 4 213 4.8E-65 T 17-03-2017 IPR011697 Peptidase C26 GO:0006541|GO:0016787 SHXM_RS24415 bec36fcdab68d3a50a0237ec18a870bd 284 Gene3D G3DSA:1.10.10.10 22 72 1.4E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24415 bec36fcdab68d3a50a0237ec18a870bd 284 SUPERFAMILY SSF46689 22 82 1.2E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS24415 bec36fcdab68d3a50a0237ec18a870bd 284 SUPERFAMILY SSF53697 97 244 1.75E-9 T 17-03-2017 SHXM_RS24415 bec36fcdab68d3a50a0237ec18a870bd 284 Gene3D G3DSA:3.40.50.10490 73 242 4.1E-7 T 17-03-2017 SHXM_RS24415 bec36fcdab68d3a50a0237ec18a870bd 284 Pfam PF01418 Helix-turn-helix domain, rpiR family 21 81 1.9E-11 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 SUPERFAMILY SSF53383 100 454 9.11E-66 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 Gene3D G3DSA:3.90.1150.10 341 449 4.3E-5 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 82 3.1E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 SUPERFAMILY SSF46785 16 91 2.73E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 SMART SM00345 23 82 4.9E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 Gene3D G3DSA:3.40.640.10 154 340 6.7E-53 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS00205 f1f6c6cb56e5d514f91fb92fa0c95544 464 Gene3D G3DSA:1.10.10.10 17 83 6.3E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 SUPERFAMILY SSF46785 3 111 2.73E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 2.2E-23 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 5.4E-11 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 5.4E-11 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 5.4E-11 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 Pfam PF03466 LysR substrate binding domain 87 292 7.6E-47 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 Gene3D G3DSA:3.40.190.10 88 186 3.2E-27 T 17-03-2017 SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 SUPERFAMILY SSF53850 90 295 6.42E-43 T 17-03-2017 SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 Gene3D G3DSA:1.10.10.10 2 85 1.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22095 2a6f221f9c709eb9b4399a656af24af2 311 Gene3D G3DSA:3.40.190.10 187 261 7.4E-21 T 17-03-2017 SHXM_RS11095 97f96f31fc26689379e15fb8cb8cadd1 746 SUPERFAMILY SSF82866 476 692 3.01E-24 T 17-03-2017 SHXM_RS11095 97f96f31fc26689379e15fb8cb8cadd1 746 Gene3D G3DSA:1.20.1640.10 478 694 6.7E-25 T 17-03-2017 SHXM_RS11095 97f96f31fc26689379e15fb8cb8cadd1 746 Gene3D G3DSA:1.20.1640.10 148 333 9.7E-28 T 17-03-2017 SHXM_RS11095 97f96f31fc26689379e15fb8cb8cadd1 746 SUPERFAMILY SSF82866 137 332 1.7E-26 T 17-03-2017 SHXM_RS11095 97f96f31fc26689379e15fb8cb8cadd1 746 Pfam PF03176 MMPL family 469 694 1.0E-28 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS11095 97f96f31fc26689379e15fb8cb8cadd1 746 Pfam PF03176 MMPL family 45 366 1.0E-47 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS25620 c7ce370ba7af176a3c1024eebc299613 286 TIGRFAM TIGR03084 TIGR03084: TIGR03084 family protein 6 257 1.7E-109 T 17-03-2017 IPR017518 Conserved hypothetical protein CHP03084 SHXM_RS25620 c7ce370ba7af176a3c1024eebc299613 286 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 11 147 3.4E-34 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS25620 c7ce370ba7af176a3c1024eebc299613 286 SUPERFAMILY SSF109854 3 152 7.63E-37 T 17-03-2017 SHXM_RS25620 c7ce370ba7af176a3c1024eebc299613 286 Gene3D G3DSA:1.20.120.450 5 142 5.5E-9 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS25620 c7ce370ba7af176a3c1024eebc299613 286 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 10 224 1.2E-50 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS25620 c7ce370ba7af176a3c1024eebc299613 286 Pfam PF08608 Wyosine base formation 184 230 9.0E-9 T 17-03-2017 IPR013917 tRNA wybutosine-synthesis MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS18775 0eab2f513f50080735fb4b7e8fb95b84 274 PIRSF PIRSF017388 2 249 6.2E-73 T 17-03-2017 IPR012354 Esterase/lipase GO:0052689 SHXM_RS18775 0eab2f513f50080735fb4b7e8fb95b84 274 Pfam PF12146 Serine aminopeptidase, S33 20 230 6.1E-23 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS18775 0eab2f513f50080735fb4b7e8fb95b84 274 Gene3D G3DSA:3.40.50.1820 13 247 5.3E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS18775 0eab2f513f50080735fb4b7e8fb95b84 274 SUPERFAMILY SSF53474 14 246 6.22E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09540 60f2e04fb8e8f0ffbb1d8f6fe1aa1e32 252 Pfam PF09234 Domain of unknown function (DUF1963) 52 248 1.9E-11 T 17-03-2017 IPR015315 Protein of unknown function DUF1963 SHXM_RS09540 60f2e04fb8e8f0ffbb1d8f6fe1aa1e32 252 SUPERFAMILY SSF103032 49 250 1.83E-7 T 17-03-2017 IPR015315 Protein of unknown function DUF1963 SHXM_RS09540 60f2e04fb8e8f0ffbb1d8f6fe1aa1e32 252 Gene3D G3DSA:2.30.320.10 161 249 8.2E-5 T 17-03-2017 IPR015315 Protein of unknown function DUF1963 SHXM_RS42545 163356cd862e1c953c3b6cd874e8ada3 317 SUPERFAMILY SSF52540 77 263 5.22E-30 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42545 163356cd862e1c953c3b6cd874e8ada3 317 TIGRFAM TIGR03707 PPK2_P_aer: polyphosphate kinase 2 45 273 4.6E-115 T 17-03-2017 IPR022486 Polyphosphate kinase 2, PA0141 GO:0006793|GO:0008976 SHXM_RS42545 163356cd862e1c953c3b6cd874e8ada3 317 Gene3D G3DSA:3.40.50.300 38 288 2.4E-108 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42545 163356cd862e1c953c3b6cd874e8ada3 317 Pfam PF03976 Polyphosphate kinase 2 (PPK2) 46 271 1.8E-102 T 17-03-2017 IPR022488 Polyphosphate kinase-2-related SHXM_RS02215 c92bae14c1fa69a0074a579e9d0d540c 258 PIRSF PIRSF015957 8 252 1.8E-115 T 17-03-2017 IPR007565 (5-formylfuran-3-yl)methyl phosphate synthase KEGG: 00680+4.2.3.153|KEGG: 00902+4.2.3.15|MetaCyc: PWY-3041|MetaCyc: PWY-5423|MetaCyc: PWY-7410 SHXM_RS02215 c92bae14c1fa69a0074a579e9d0d540c 258 Pfam PF04476 Putative methanogenic enzyme for methanofuran 10 239 1.8E-81 T 17-03-2017 IPR007565 (5-formylfuran-3-yl)methyl phosphate synthase KEGG: 00680+4.2.3.153|KEGG: 00902+4.2.3.15|MetaCyc: PWY-3041|MetaCyc: PWY-5423|MetaCyc: PWY-7410 SHXM_RS02215 c92bae14c1fa69a0074a579e9d0d540c 258 SUPERFAMILY SSF51366 14 226 1.37E-7 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS21360 0b8533f78b5039b7c99ba3c91f8c2985 176 Pfam PF00583 Acetyltransferase (GNAT) family 68 156 7.1E-7 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS21360 0b8533f78b5039b7c99ba3c91f8c2985 176 SUPERFAMILY SSF55729 7 162 1.7E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21360 0b8533f78b5039b7c99ba3c91f8c2985 176 Gene3D G3DSA:3.40.630.30 5 160 4.7E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 SUPERFAMILY SSF55874 320 467 1.3E-27 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 SMART SM00388 245 312 5.5E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 SUPERFAMILY SSF47384 232 306 1.96E-10 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 PRINTS PR00344 Bacterial sensor protein C-terminal signature 428 446 9.7E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 PRINTS PR00344 Bacterial sensor protein C-terminal signature 416 426 9.7E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 PRINTS PR00344 Bacterial sensor protein C-terminal signature 454 467 9.7E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 PRINTS PR00344 Bacterial sensor protein C-terminal signature 398 412 9.7E-11 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 SMART SM00387 354 470 4.3E-26 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 Pfam PF00512 His Kinase A (phospho-acceptor) domain 247 309 1.7E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 Gene3D G3DSA:1.10.287.130 237 303 1.6E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 Gene3D G3DSA:3.30.565.10 319 471 1.7E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13850 06a4eb74caae4e913b149b50949641b8 500 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 356 469 2.2E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21000 766ec57332dd92c88097a7e7f2e91971 404 Gene3D G3DSA:3.30.565.10 320 402 1.4E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21000 766ec57332dd92c88097a7e7f2e91971 404 Pfam PF07730 Histidine kinase 214 281 3.2E-16 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS21000 766ec57332dd92c88097a7e7f2e91971 404 SUPERFAMILY SSF55874 290 401 9.9E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 TIGRFAM TIGR01462 greA: transcription elongation factor GreA 10 160 3.1E-43 T 17-03-2017 IPR006359 Transcription elongation factor GreA GO:0003677|GO:0032784 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 Hamap MF_00105 Transcription elongation factor GreA [greA]. 7 161 27.451 T 17-03-2017 IPR028624 Transcription elongation factor GreA/GreB GO:0003677|GO:0032784|GO:0070063 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 SUPERFAMILY SSF54534 84 160 4.05E-11 T 17-03-2017 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 ProSitePatterns PS00829 Prokaryotic transcription elongation factors signature 1. 22 53 - T 17-03-2017 IPR018151 Transcription elongation factor, GreA/GreB, conserved site GO:0003677|GO:0032784 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 SUPERFAMILY SSF46557 8 82 3.66E-23 T 17-03-2017 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 Gene3D G3DSA:1.10.287.180 7 79 5.5E-27 T 17-03-2017 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 PIRSF PIRSF006092 3 164 8.6E-33 T 17-03-2017 IPR023459 Transcription elongation factor GreA/GreB family GO:0070063 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 Pfam PF01272 Transcription elongation factor, GreA/GreB, C-term 86 161 1.2E-12 T 17-03-2017 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 Gene3D G3DSA:3.10.50.30 81 163 3.5E-16 T 17-03-2017 IPR001437 Transcription elongation factor, GreA/GreB, C-terminal GO:0003677|GO:0032784 SHXM_RS33210 4b0d6a83283a8038137685184b610183 165 Pfam PF03449 Transcription elongation factor, N-terminal 10 79 7.1E-25 T 17-03-2017 IPR022691 Transcription elongation factor, GreA/GreB, N-terminal GO:0003677|GO:0032784 SHXM_RS31355 308e17790674930c8d9073863cca09a7 695 Pfam PF00534 Glycosyl transferases group 1 204 361 2.8E-36 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS31355 308e17790674930c8d9073863cca09a7 695 SUPERFAMILY SSF53756 93 383 5.83E-66 T 17-03-2017 SHXM_RS31355 308e17790674930c8d9073863cca09a7 695 SUPERFAMILY SSF53756 2 45 5.83E-66 T 17-03-2017 SHXM_RS31355 308e17790674930c8d9073863cca09a7 695 Gene3D G3DSA:3.40.50.2000 203 361 7.8E-24 T 17-03-2017 SHXM_RS07565 73bbe1efe6d643d516a494b35f70b5ae 593 Pfam PF00069 Protein kinase domain 15 211 2.4E-40 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS07565 73bbe1efe6d643d516a494b35f70b5ae 593 Gene3D G3DSA:1.10.510.10 121 211 7.4E-27 T 17-03-2017 SHXM_RS07565 73bbe1efe6d643d516a494b35f70b5ae 593 SUPERFAMILY SSF56112 18 253 1.62E-53 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS07565 73bbe1efe6d643d516a494b35f70b5ae 593 Gene3D G3DSA:3.30.200.20 21 120 9.8E-28 T 17-03-2017 SHXM_RS07565 73bbe1efe6d643d516a494b35f70b5ae 593 SMART SM00220 14 257 1.4E-44 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS07565 73bbe1efe6d643d516a494b35f70b5ae 593 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 130 142 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 Gene3D G3DSA:1.25.40.10 525 711 3.9E-20 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 SMART SM00028 659 692 120.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 SMART SM00028 579 612 42.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 SMART SM00028 619 652 16.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 SMART SM00028 539 572 11.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 Pfam PF00931 NB-ARC domain 115 299 8.7E-10 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 SUPERFAMILY SSF48452 538 694 8.09E-20 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 Pfam PF13424 Tetratricopeptide repeat 538 609 6.8E-11 T 17-03-2017 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 Pfam PF13424 Tetratricopeptide repeat 618 690 1.7E-8 T 17-03-2017 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 Gene3D G3DSA:3.40.50.300 117 210 1.1E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 SUPERFAMILY SSF52540 116 343 3.43E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 PRINTS PR00364 Disease resistance protein signature 282 296 2.9E-7 T 17-03-2017 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 PRINTS PR00364 Disease resistance protein signature 197 211 2.9E-7 T 17-03-2017 SHXM_RS17090 29c2090a449d4d31a77d27bd34e0c586 754 PRINTS PR00364 Disease resistance protein signature 121 136 2.9E-7 T 17-03-2017 SHXM_RS17260 bb1b327d6d04fdbd92b110cf3e4cd481 247 Gene3D G3DSA:1.10.530.10 158 242 5.3E-9 T 17-03-2017 SHXM_RS17260 bb1b327d6d04fdbd92b110cf3e4cd481 247 Pfam PF01464 Transglycosylase SLT domain 173 242 1.3E-8 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS17260 bb1b327d6d04fdbd92b110cf3e4cd481 247 SUPERFAMILY SSF53955 145 241 1.75E-14 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS25675 02b8c39340144ab3b753055cd333a92f 460 Gene3D G3DSA:1.20.1250.20 46 232 1.3E-19 T 17-03-2017 SHXM_RS25675 02b8c39340144ab3b753055cd333a92f 460 SUPERFAMILY SSF103473 43 428 9.02E-49 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS25675 02b8c39340144ab3b753055cd333a92f 460 Pfam PF05977 Transmembrane secretion effector 36 418 2.3E-52 T 17-03-2017 IPR010290 Transmembrane secretion effector SHXM_RS25675 02b8c39340144ab3b753055cd333a92f 460 Gene3D G3DSA:1.20.1250.20 255 427 2.6E-14 T 17-03-2017 SHXM_RS03220 96932d56827157cf313208f36e09d065 686 Pfam PF05506 Domain of unknown function (DUF756) 496 583 3.4E-22 T 17-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SHXM_RS03220 96932d56827157cf313208f36e09d065 686 Pfam PF05506 Domain of unknown function (DUF756) 589 670 8.1E-17 T 17-03-2017 IPR008475 Bacterial phospholipase C, C-terminal domain GO:0004629|GO:0016042 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SHXM_RS03220 96932d56827157cf313208f36e09d065 686 Pfam PF04185 Phosphoesterase family 44 427 1.9E-116 T 17-03-2017 IPR007312 Phosphoesterase GO:0016788 SHXM_RS03220 96932d56827157cf313208f36e09d065 686 TIGRFAM TIGR03396 PC_PLC: phospholipase C, phosphocholine-specific 5 683 3.6E-263 T 17-03-2017 IPR017767 Bacterial phospholipase C, phosphocholine-specific GO:0034480 KEGG: 00562+3.1.4.3|KEGG: 00564+3.1.4.3|KEGG: 00565+3.1.4.3 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 Gene3D G3DSA:1.25.40.10 471 710 2.3E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 Pfam PF00931 NB-ARC domain 88 277 4.2E-7 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 SUPERFAMILY SSF52540 75 278 2.5E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 SUPERFAMILY SSF48452 471 604 3.54E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 Gene3D G3DSA:3.40.50.300 74 129 1.1E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 Pfam PF13424 Tetratricopeptide repeat 463 536 3.0E-8 T 17-03-2017 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 Pfam PF13424 Tetratricopeptide repeat 630 703 1.6E-12 T 17-03-2017 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 Pfam PF13374 Tetratricopeptide repeat 561 585 0.0021 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 PRINTS PR00364 Disease resistance protein signature 255 269 1.7E-5 T 17-03-2017 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 PRINTS PR00364 Disease resistance protein signature 90 105 1.7E-5 T 17-03-2017 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 PRINTS PR00364 Disease resistance protein signature 168 182 1.7E-5 T 17-03-2017 SHXM_RS21810 07447da9d7c6f018271b32fac8302b83 733 SUPERFAMILY SSF48452 607 717 1.71E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31475 e440690724d45779d5e9298b7fe32430 313 Pfam PF00561 alpha/beta hydrolase fold 31 161 2.3E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS31475 e440690724d45779d5e9298b7fe32430 313 SUPERFAMILY SSF53474 5 313 3.78E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS31475 e440690724d45779d5e9298b7fe32430 313 Gene3D G3DSA:3.40.50.1820 5 313 7.0E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS36400 4f25f9babbb6924cf8c73a87a2e5e4f8 77 SUPERFAMILY SSF54909 2 75 5.9E-15 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS36400 4f25f9babbb6924cf8c73a87a2e5e4f8 77 Pfam PF01037 Lrp/AsnC ligand binding domain 6 74 6.7E-13 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS36400 4f25f9babbb6924cf8c73a87a2e5e4f8 77 Gene3D G3DSA:3.30.70.920 4 75 4.2E-17 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS05650 f40ba36fd353ee40b93381906a959052 300 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 8 63 1.5E-17 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05650 f40ba36fd353ee40b93381906a959052 300 Gene3D G3DSA:1.10.10.10 7 86 5.6E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05650 f40ba36fd353ee40b93381906a959052 300 SUPERFAMILY SSF46785 6 105 1.25E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Gene3D G3DSA:3.40.50.140 13 156 1.4E-48 T 17-03-2017 IPR006171 Toprim domain SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 SMART SM00437 289 556 3.1E-120 T 17-03-2017 IPR003602 DNA topoisomerase, type IA, DNA-binding domain GO:0003677|GO:0003916|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 SMART SM00493 13 126 1.4E-35 T 17-03-2017 IPR006171 Toprim domain SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Pfam PF01131 DNA topoisomerase 150 593 7.3E-128 T 17-03-2017 IPR013497 DNA topoisomerase, type IA, central GO:0003677|GO:0003916|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 SMART SM00436 126 214 4.0E-46 T 17-03-2017 IPR003601 DNA topoisomerase, type IA, domain 2 GO:0003677|GO:0003916|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 ProSitePatterns PS00396 Prokaryotic DNA topoisomerase I active site. 326 340 - T 17-03-2017 IPR023406 DNA topoisomerase, type IA, active site GO:0003917 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Pfam PF13368 Topoisomerase C-terminal repeat 641 693 8.8E-7 T 17-03-2017 IPR025589 Topoisomerase C-terminal repeat SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Pfam PF13368 Topoisomerase C-terminal repeat 769 821 7.1E-16 T 17-03-2017 IPR025589 Topoisomerase C-terminal repeat SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Pfam PF13368 Topoisomerase C-terminal repeat 834 886 3.7E-20 T 17-03-2017 IPR025589 Topoisomerase C-terminal repeat SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Pfam PF13368 Topoisomerase C-terminal repeat 701 764 1.5E-14 T 17-03-2017 IPR025589 Topoisomerase C-terminal repeat SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Hamap MF_00952 DNA topoisomerase 1 [topA]. 13 780 55.389 T 17-03-2017 IPR028612 DNA topoisomerase I, type IA GO:0003677|GO:0003916|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 TIGRFAM TIGR01051 topA_bact: DNA topoisomerase I 15 659 2.5E-242 T 17-03-2017 IPR005733 DNA topoisomerase I, bacterial-type GO:0003677|GO:0003917|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 SUPERFAMILY SSF56712 13 597 9.68E-180 T 17-03-2017 IPR023405 DNA topoisomerase, type IA, core domain SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 100 113 3.3E-33 T 17-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 408 424 3.3E-33 T 17-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 519 533 3.3E-33 T 17-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 331 340 3.3E-33 T 17-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 PRINTS PR00417 Prokaryotic DNA topoisomerase I signature 184 202 3.3E-33 T 17-03-2017 IPR000380 DNA topoisomerase, type IA GO:0003677|GO:0003917|GO:0006265 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Gene3D G3DSA:1.10.460.10 157 204 2.4E-50 T 17-03-2017 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Gene3D G3DSA:1.10.460.10 503 597 2.4E-50 T 17-03-2017 IPR013824 DNA topoisomerase, type IA, central region, subdomain 1 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Pfam PF01751 Toprim domain 15 135 8.0E-28 T 17-03-2017 IPR006171 Toprim domain SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Gene3D G3DSA:2.70.20.10 356 502 2.5E-34 T 17-03-2017 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 SHXM_RS26865 8975b82e2b351c90f67f6eb2552a6436 945 Gene3D G3DSA:2.70.20.10 206 355 7.4E-26 T 17-03-2017 IPR013825 DNA topoisomerase, type IA, central region, subdomain 2 SHXM_RS16860 99f4a73d776439180d8d691ff8fd35d1 138 TIGRFAM TIGR03561 organ_hyd_perox: peroxiredoxin, Ohr subfamily 5 135 9.5E-51 T 17-03-2017 IPR019953 Organic hydroperoxide resistance protein famiy GO:0006979 SHXM_RS16860 99f4a73d776439180d8d691ff8fd35d1 138 Gene3D G3DSA:2.20.25.10 1 43 1.8E-17 T 17-03-2017 SHXM_RS16860 99f4a73d776439180d8d691ff8fd35d1 138 Pfam PF02566 OsmC-like protein 37 135 5.2E-21 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS16860 99f4a73d776439180d8d691ff8fd35d1 138 SUPERFAMILY SSF82784 2 136 5.1E-40 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS16860 99f4a73d776439180d8d691ff8fd35d1 138 Gene3D G3DSA:3.30.300.20 44 136 2.6E-36 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SMART SM01043 100 267 4.9E-40 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Pfam PF00931 NB-ARC domain 435 614 5.1E-13 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SUPERFAMILY SSF48452 141 270 5.18E-26 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Gene3D G3DSA:1.25.40.10 850 1045 7.1E-27 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Gene3D G3DSA:1.25.40.10 145 243 7.1E-27 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Gene3D G3DSA:1.10.10.10 27 94 2.4E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Pfam PF13424 Tetratricopeptide repeat 978 1047 1.5E-8 T 17-03-2017 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SUPERFAMILY SSF48452 848 1049 2.56E-29 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SMART SM00028 857 890 1.5 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SMART SM00028 1017 1050 17.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SMART SM00028 937 970 0.15 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SMART SM00028 977 1010 0.0067 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SMART SM00862 18 93 1.7E-11 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Pfam PF00486 Transcriptional regulatory protein, C terminal 26 92 6.4E-10 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Pfam PF13374 Tetratricopeptide repeat 937 970 0.004 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 PRINTS PR00364 Disease resistance protein signature 514 528 1.8E-8 T 17-03-2017 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 PRINTS PR00364 Disease resistance protein signature 435 450 1.8E-8 T 17-03-2017 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 PRINTS PR00364 Disease resistance protein signature 602 616 1.8E-8 T 17-03-2017 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SUPERFAMILY SSF46894 5 93 9.64E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 SUPERFAMILY SSF52540 397 671 1.29E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Gene3D G3DSA:3.40.50.300 433 550 1.5E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35690 71666d136331ada819648f8b1a011843 1070 Pfam PF03704 Bacterial transcriptional activator domain 138 265 2.0E-33 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 Pfam PF12840 Helix-turn-helix domain 278 336 1.9E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 SMART SM00418 278 356 1.4E-24 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 SUPERFAMILY SSF46785 267 351 8.61E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 Gene3D G3DSA:1.10.10.10 266 356 2.1E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 312 327 3.5E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 280 295 3.5E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26355 1877ba9b310f5085d9b6211e47b71d21 360 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 327 342 3.5E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS15640 6a8322a43e92edcd76f4eebcf92431ca 249 SUPERFAMILY SSF52200 4 100 1.18E-6 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS15640 6a8322a43e92edcd76f4eebcf92431ca 249 Pfam PF13676 TIR domain 4 122 5.6E-13 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS21505 86bf4d5a14db690fbfd69a28b04fc69d 281 TIGRFAM TIGR00762 DegV: EDD domain protein, DegV family 5 278 1.5E-86 T 17-03-2017 IPR003797 DegV SHXM_RS21505 86bf4d5a14db690fbfd69a28b04fc69d 281 Gene3D G3DSA:3.30.1180.10 155 280 1.2E-40 T 17-03-2017 SHXM_RS21505 86bf4d5a14db690fbfd69a28b04fc69d 281 Pfam PF02645 Uncharacterised protein, DegV family COG1307 5 280 2.7E-85 T 17-03-2017 IPR003797 DegV SHXM_RS21505 86bf4d5a14db690fbfd69a28b04fc69d 281 Gene3D G3DSA:3.40.50.10170 5 150 2.5E-44 T 17-03-2017 SHXM_RS21505 86bf4d5a14db690fbfd69a28b04fc69d 281 SUPERFAMILY SSF82549 5 280 1.36E-75 T 17-03-2017 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 Gene3D G3DSA:3.40.1190.20 250 506 1.9E-85 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 SUPERFAMILY SSF64153 4 265 1.02E-45 T 17-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 Pfam PF03853 YjeF-related protein N-terminus 25 210 2.9E-34 T 17-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 PIRSF PIRSF017184 1 497 6.7E-107 T 17-03-2017 IPR030677 Bifunctional NAD(P)H-hydrate repair enzyme Nnr GO:0052855 MetaCyc: PWY-6938 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 SUPERFAMILY SSF53613 244 505 5.52E-61 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 ProSitePatterns PS01050 YjeF C-terminal domain signature 2. 445 455 - T 17-03-2017 IPR017953 Carbohydrate kinase, predicted, conserved site SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 Gene3D G3DSA:3.40.50.10260 4 249 5.6E-52 T 17-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 Hamap MF_01965 ADP-dependent (S)-NAD(P)H-hydrate dehydratase [nnrD]. 244 509 21.032 T 17-03-2017 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 TIGRFAM TIGR00196 yjeF_cterm: YjeF family C-terminal domain 244 504 5.0E-50 T 17-03-2017 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 Hamap MF_01966 NAD(P)H-hydrate epimerase [nnrE]. 2 231 19.916 T 17-03-2017 IPR004443 YjeF N-terminal domain MetaCyc: PWY-6938 SHXM_RS31420 5e81ac183adde8bb7304a754ac98d169 509 Pfam PF01256 Carbohydrate kinase 267 499 1.4E-55 T 17-03-2017 IPR000631 ATP-dependent (S)-NAD(P)H-hydrate dehydratase GO:0052855 Reactome: R-HSA-197264 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 SUPERFAMILY SSF51905 305 374 6.05E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 SUPERFAMILY SSF51905 19 188 6.05E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Pfam PF03466 LysR substrate binding domain 523 725 1.5E-14 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Gene3D G3DSA:1.10.10.10 430 512 1.2E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 SUPERFAMILY SSF46785 431 512 5.33E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Gene3D G3DSA:3.50.50.60 296 373 8.9E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Gene3D G3DSA:3.50.50.60 23 194 8.9E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 24 46 5.6E-12 T 17-03-2017 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 310 325 5.6E-12 T 17-03-2017 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 168 183 5.6E-12 T 17-03-2017 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Pfam PF01494 FAD binding domain 25 187 2.3E-9 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 470 481 1.1E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 449 460 1.1E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 460 470 1.1E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Gene3D G3DSA:3.40.190.10 516 603 2.7E-17 T 17-03-2017 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Gene3D G3DSA:3.40.190.10 701 728 2.7E-17 T 17-03-2017 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Gene3D G3DSA:3.40.190.10 604 693 2.0E-11 T 17-03-2017 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 435 492 7.8E-14 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46770 7be0982a5cacd9fe8ebe1ad790718ac5 729 SUPERFAMILY SSF53850 516 725 9.95E-30 T 17-03-2017 SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 427 673 1.4E-47 T 17-03-2017 SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 SUPERFAMILY SSF53639 17 217 1.26E-30 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 543 559 2.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 422 439 2.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 590 607 2.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 569 588 2.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 495 506 2.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 SMART SM01007 11 213 1.8E-34 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 549 557 6.0E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 569 588 6.0E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 495 506 6.0E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 TIGRFAM TIGR02632 RhaD_aldol-ADH: rhamnulose-1-phosphate aldolase/alcohol dehydrogenase 10 679 0.0 T 17-03-2017 IPR013454 Bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 14 210 8.6E-22 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 Gene3D G3DSA:3.40.225.10 13 216 2.0E-29 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 Gene3D G3DSA:3.40.50.720 400 674 1.8E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11405 a8b3f7684414404c1110627a07527e58 679 SUPERFAMILY SSF51735 409 676 4.36E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43845 f3804261e26ee8d18513cf7e829c89c3 270 Gene3D G3DSA:1.10.3720.10 13 263 1.8E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43845 f3804261e26ee8d18513cf7e829c89c3 270 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 80 261 1.9E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43845 f3804261e26ee8d18513cf7e829c89c3 270 SUPERFAMILY SSF161098 5 261 9.68E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 SUPERFAMILY SSF52540 269 536 1.5E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 SUPERFAMILY SSF48452 829 989 2.96E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 Gene3D G3DSA:1.25.40.10 831 954 1.6E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 Gene3D G3DSA:3.40.50.300 286 429 2.4E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 Gene3D G3DSA:1.25.40.10 99 210 4.9E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 Pfam PF03704 Bacterial transcriptional activator domain 95 237 6.2E-39 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 SMART SM00862 16 88 6.3E-9 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 PRINTS PR00364 Disease resistance protein signature 469 483 2.1E-5 T 17-03-2017 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 PRINTS PR00364 Disease resistance protein signature 291 306 2.1E-5 T 17-03-2017 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 PRINTS PR00364 Disease resistance protein signature 376 390 2.1E-5 T 17-03-2017 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 SUPERFAMILY SSF48452 91 258 6.17E-32 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 Pfam PF00486 Transcriptional regulatory protein, C terminal 25 87 7.3E-5 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 SMART SM01043 95 237 1.8E-42 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 SUPERFAMILY SSF46894 6 88 7.37E-9 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS19405 163df641b6cc52d85f219cb269185d49 1136 Gene3D G3DSA:1.10.10.10 15 91 2.6E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13430 36025ab3d708c954e258687571d98b98 250 Pfam PF00483 Nucleotidyl transferase 3 155 1.7E-10 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS13430 36025ab3d708c954e258687571d98b98 250 SUPERFAMILY SSF53448 1 242 1.19E-32 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS13430 36025ab3d708c954e258687571d98b98 250 Gene3D G3DSA:3.90.550.10 2 243 3.3E-34 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS08735 813287c5b0723809975868d95f608312 258 SUPERFAMILY SSF46785 1 53 2.83E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08735 813287c5b0723809975868d95f608312 258 Gene3D G3DSA:1.10.10.10 1 53 1.4E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08735 813287c5b0723809975868d95f608312 258 Gene3D G3DSA:3.40.190.10 69 154 8.4E-9 T 17-03-2017 SHXM_RS08735 813287c5b0723809975868d95f608312 258 SUPERFAMILY SSF53850 57 246 1.49E-15 T 17-03-2017 SHXM_RS08735 813287c5b0723809975868d95f608312 258 Pfam PF03466 LysR substrate binding domain 57 243 3.9E-12 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS08735 813287c5b0723809975868d95f608312 258 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 1 30 3.5E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48005 5c51fc2e513815c1741602cfda195670 83 Gene3D G3DSA:1.10.3720.10 2 75 4.8E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48005 5c51fc2e513815c1741602cfda195670 83 SUPERFAMILY SSF161098 2 66 5.07E-8 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 Pfam PF00005 ABC transporter 45 206 2.4E-22 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 256 343 4.5E-22 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 ProSitePatterns PS00211 ABC transporters family signature. 179 193 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 SMART SM00382 53 256 1.7E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 SUPERFAMILY SSF52540 17 285 1.25E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 258 322 5.1E-18 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS48430 18e97e4b01f2cc09fd56b7e5b592f507 356 Gene3D G3DSA:3.40.50.300 23 278 6.6E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20215 4f92184c034cc6cc136e626612340036 191 Pfam PF02342 TerD domain 1 186 9.4E-82 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS20215 4f92184c034cc6cc136e626612340036 191 Gene3D G3DSA:2.60.60.30 18 183 8.7E-72 T 17-03-2017 SHXM_RS35575 deeb7b003f26501c36d704be239e93ee 205 Gene3D G3DSA:1.10.10.60 2 53 1.6E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35575 deeb7b003f26501c36d704be239e93ee 205 SUPERFAMILY SSF46689 2 78 2.15E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35575 deeb7b003f26501c36d704be239e93ee 205 Gene3D G3DSA:1.10.357.10 54 200 1.0E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS35575 deeb7b003f26501c36d704be239e93ee 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 56 1.3E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS01185 5ccb130dbe2a897315105d5cf0d126b3 950 Pfam PF14028 Lantibiotic biosynthesis dehydratase C-term 707 946 9.4E-25 T 17-03-2017 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SHXM_RS01185 5ccb130dbe2a897315105d5cf0d126b3 950 Pfam PF04738 Lantibiotic dehydratase, C terminus 31 636 9.0E-117 T 17-03-2017 IPR006827 Lantibiotic dehydratase, C-terminal SHXM_RS01185 5ccb130dbe2a897315105d5cf0d126b3 950 TIGRFAM TIGR03891 thiopep_ocin: thiopeptide-type bacteriocin biosynthesis domain 707 946 2.7E-39 T 17-03-2017 IPR023809 Thiopeptide-type bacteriocin biosynthesis domain SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 Pfam PF01336 OB-fold nucleic acid binding domain 1022 1099 1.6E-6 T 17-03-2017 IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type GO:0003676 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 Gene3D G3DSA:2.40.50.140 1017 1098 2.6E-4 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 Pfam PF07733 Bacterial DNA polymerase III alpha subunit 316 755 2.5E-162 T 17-03-2017 IPR011708 Bacterial DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 SUPERFAMILY SSF89550 7 92 1.37E-30 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 SUPERFAMILY SSF89550 120 269 1.37E-30 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 Pfam PF02811 PHP domain 8 194 8.1E-46 T 17-03-2017 IPR004013 PHP domain GO:0003824 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 TIGRFAM TIGR00594 polc: DNA polymerase III, alpha subunit 6 1059 0.0 T 17-03-2017 IPR004805 DNA polymerase III, alpha subunit GO:0006260|GO:0008408 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 Pfam PF14579 Helix-hairpin-helix motif 829 917 1.3E-24 T 17-03-2017 IPR029460 DNA polymerase, helix-hairpin-helix motif KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 SMART SM00481 7 74 3.4E-30 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS18465 3b4ea6773d73fd8922771da6d705cf73 1181 Gene3D G3DSA:3.20.20.140 7 268 4.7E-40 T 17-03-2017 SHXM_RS23660 6bb051a49d7e6df94049ea0bcb82426d 289 Gene3D G3DSA:1.10.3720.10 12 277 3.9E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23660 6bb051a49d7e6df94049ea0bcb82426d 289 SUPERFAMILY SSF161098 11 283 2.8E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23660 6bb051a49d7e6df94049ea0bcb82426d 289 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 94 281 4.5E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 256 3.6E-49 T 17-03-2017 SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 SUPERFAMILY SSF51735 4 259 1.13E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 7.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 7.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 221 241 7.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 7.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 7.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 7.6E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31905 d27d7a13579857b705564611f36dbf87 260 Gene3D G3DSA:3.40.50.720 2 257 2.2E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20275 921060684195da766a18d505f3c61b47 403 SUPERFAMILY SSF53474 136 156 1.39E-6 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20275 921060684195da766a18d505f3c61b47 403 SUPERFAMILY SSF53474 227 326 1.39E-6 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20275 921060684195da766a18d505f3c61b47 403 Gene3D G3DSA:3.40.50.1820 241 356 3.6E-5 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20275 921060684195da766a18d505f3c61b47 403 Gene3D G3DSA:3.40.50.1820 136 158 3.6E-5 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20275 921060684195da766a18d505f3c61b47 403 Pfam PF06259 Alpha/beta hydrolase 149 325 2.4E-45 T 17-03-2017 IPR010427 Protein of unknown function DUF1023 SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 Gene3D G3DSA:1.10.530.10 260 360 2.9E-28 T 17-03-2017 SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 SMART SM01208 195 273 1.4E-22 T 17-03-2017 IPR011098 G5 domain SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 Pfam PF07501 G5 domain 202 272 2.9E-20 T 17-03-2017 IPR011098 G5 domain SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 SUPERFAMILY SSF53955 282 359 1.91E-22 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 Pfam PF06737 Transglycosylase-like domain 283 355 3.6E-22 T 17-03-2017 IPR010618 Transglycosylase-like SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 Pfam PF03990 Domain of unknown function (DUF348) 85 122 3.1E-8 T 17-03-2017 IPR007137 Resuscitation-promoting factor, domain of unknown function DUF348 SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 Pfam PF03990 Domain of unknown function (DUF348) 142 182 1.7E-10 T 17-03-2017 IPR007137 Resuscitation-promoting factor, domain of unknown function DUF348 SHXM_RS32675 d9ccae00a867fd857f6e112f74899a79 361 Pfam PF03990 Domain of unknown function (DUF348) 28 67 5.2E-12 T 17-03-2017 IPR007137 Resuscitation-promoting factor, domain of unknown function DUF348 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 Gene3D G3DSA:1.20.140.10 203 367 1.0E-37 T 17-03-2017 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 Gene3D G3DSA:1.10.540.10 8 109 4.7E-23 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 SUPERFAMILY SSF47203 220 364 1.61E-34 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 219 362 4.4E-30 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 112 202 3.1E-19 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 108 5.1E-15 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 SUPERFAMILY SSF56645 8 212 1.19E-53 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS16750 48809b9387f82fc06eb841e036f01d5f 369 Gene3D G3DSA:2.40.110.10 112 202 3.2E-28 T 17-03-2017 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 Gene3D G3DSA:1.25.40.10 600 682 4.0E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SUPERFAMILY SSF48452 668 779 2.47E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SUPERFAMILY SSF52540 46 320 2.13E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 Pfam PF13424 Tetratricopeptide repeat 506 573 2.5E-10 T 17-03-2017 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 Pfam PF13424 Tetratricopeptide repeat 670 734 1.9E-8 T 17-03-2017 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 Gene3D G3DSA:3.40.50.300 83 175 6.7E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 PRINTS PR00364 Disease resistance protein signature 249 263 9.3E-6 T 17-03-2017 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 PRINTS PR00364 Disease resistance protein signature 83 98 9.3E-6 T 17-03-2017 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 PRINTS PR00364 Disease resistance protein signature 161 175 9.3E-6 T 17-03-2017 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 Gene3D G3DSA:1.25.40.10 683 784 2.4E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SUPERFAMILY SSF48452 503 661 4.96E-19 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 Gene3D G3DSA:1.25.40.10 506 599 1.8E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SMART SM00028 546 579 8.3 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SMART SM00028 506 539 30.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SMART SM00028 666 699 28.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SMART SM00028 586 619 470.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SMART SM00028 626 659 170.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35610 04521b19c93f2e534d350886fbe6b768 793 SMART SM00028 706 739 25.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS01975 f5ff22e492b2c98445ec38aeaf989a04 301 Pfam PF03180 NLPA lipoprotein 60 289 1.3E-43 T 17-03-2017 IPR004872 Lipoprotein NlpA family SHXM_RS01975 f5ff22e492b2c98445ec38aeaf989a04 301 SUPERFAMILY SSF53850 51 283 4.34E-40 T 17-03-2017 SHXM_RS01975 f5ff22e492b2c98445ec38aeaf989a04 301 Gene3D G3DSA:3.40.190.10 50 182 1.2E-32 T 17-03-2017 SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 Pfam PF02927 Cellulase N-terminal ig-like domain 40 122 2.4E-22 T 17-03-2017 IPR004197 Cellulase, Ig-like domain GO:0005975|GO:0008810 SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 Gene3D G3DSA:2.60.40.10 40 129 1.1E-27 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 SUPERFAMILY SSF81296 42 130 1.12E-19 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 Pfam PF00759 Glycosyl hydrolase family 9 133 603 2.3E-103 T 17-03-2017 IPR001701 Glycoside hydrolase family 9 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 ProSitePatterns PS00698 Glycosyl hydrolases family 9 active sites signature 2. 580 598 - T 17-03-2017 IPR033126 Glycosyl hydrolases family 9, Asp/Glu active sites KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 Gene3D G3DSA:1.50.10.10 132 609 4.2E-158 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS05460 808de5f8eca51aab6b43596b97cedc6f 620 SUPERFAMILY SSF48208 133 609 1.32E-128 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 Gene3D G3DSA:1.20.140.10 211 360 2.0E-24 T 17-03-2017 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 Gene3D G3DSA:2.40.110.10 117 210 1.9E-16 T 17-03-2017 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 SUPERFAMILY SSF56645 40 220 1.44E-33 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 Gene3D G3DSA:1.10.540.10 41 114 8.2E-8 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 118 208 7.4E-15 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 SUPERFAMILY SSF47203 219 365 1.3E-22 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 28 113 3.2E-8 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS47075 ca38e6b8ff1cbe36aca55817e2089343 375 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 219 355 7.4E-20 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS50250 c176d85b5843fcc52fd672d7c065ca6e 298 SUPERFAMILY SSF53697 7 248 2.45E-65 T 17-03-2017 SHXM_RS50250 c176d85b5843fcc52fd672d7c065ca6e 298 ProSitePatterns PS01272 Glucokinase regulatory protein family signature. 185 202 - T 17-03-2017 IPR005486 Glucokinase regulatory protein, conserved site KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126|Reactome: R-HSA-170822|Reactome: R-HSA-5619107 SHXM_RS50250 c176d85b5843fcc52fd672d7c065ca6e 298 TIGRFAM TIGR00274 TIGR00274: N-acetylmuramic acid 6-phosphate etherase 7 295 3.8E-114 T 17-03-2017 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126 SHXM_RS50250 c176d85b5843fcc52fd672d7c065ca6e 298 Hamap MF_00068 N-acetylmuramic acid 6-phosphate etherase [murQ]. 2 295 41.612 T 17-03-2017 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126 SHXM_RS50250 c176d85b5843fcc52fd672d7c065ca6e 298 Pfam PF01380 SIS domain 129 208 3.4E-7 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS50250 c176d85b5843fcc52fd672d7c065ca6e 298 Gene3D G3DSA:3.40.50.10490 5 248 1.1E-80 T 17-03-2017 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 Pfam PF00072 Response regulator receiver domain 35 146 2.0E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 SMART SM00421 183 240 3.2E-28 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 Gene3D G3DSA:3.40.50.2300 29 152 3.1E-38 T 17-03-2017 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 SUPERFAMILY SSF46894 169 246 3.74E-24 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 SMART SM00448 33 146 1.3E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 Gene3D G3DSA:1.10.10.10 153 247 9.7E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 ProSitePatterns PS00622 LuxR-type HTH domain signature. 200 227 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 Pfam PF00196 Bacterial regulatory proteins, luxR family 185 240 4.6E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 216 228 7.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 200 7.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 200 216 7.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24095 99bd8dce33d5f51e4da0a141f9adc878 249 SUPERFAMILY SSF52172 32 162 3.84E-36 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 SUPERFAMILY SSF46785 7 88 1.97E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 Pfam PF03466 LysR substrate binding domain 97 293 6.0E-12 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 8 66 1.0E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 Gene3D G3DSA:3.40.190.10 182 269 3.1E-5 T 17-03-2017 SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 Gene3D G3DSA:3.40.190.10 134 181 8.6E-8 T 17-03-2017 SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 33 43 5.4E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 22 33 5.4E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 43 54 5.4E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 Gene3D G3DSA:1.10.10.10 5 84 1.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23755 90e8fd9797c660a06ef7a545ff43f6bc 327 SUPERFAMILY SSF53850 97 298 2.9E-11 T 17-03-2017 SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 Gene3D G3DSA:2.40.50.140 2 59 2.8E-23 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 SMART SM00357 3 65 2.6E-19 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 SUPERFAMILY SSF50249 2 56 1.61E-18 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 Pfam PF00313 'Cold-shock' DNA-binding domain 3 56 1.8E-23 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 PRINTS PR00050 Cold shock protein signature 40 58 1.1E-12 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 PRINTS PR00050 Cold shock protein signature 25 34 1.1E-12 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39915 77577ce7209738bdecb6726f1cf505ff 80 PRINTS PR00050 Cold shock protein signature 4 19 1.1E-12 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:3.30.300.30 410 511 3.7E-22 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 786 814 - T 17-03-2017 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:2.160.10.10 993 1069 3.8E-5 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:3.40.50.980 37 191 1.2E-32 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Pfam PF00501 AMP-binding enzyme 45 415 2.0E-63 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:3.40.50.980 204 332 4.0E-33 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 SUPERFAMILY SSF51161 1189 1303 9.7E-19 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Pfam PF00550 Phosphopantetheine attachment site 530 591 2.4E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 SMART SM00823 Phosphopantetheine attachment site 528 596 0.0016 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 SUPERFAMILY SSF56801 37 540 1.83E-108 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:2.30.38.10 333 404 8.6E-14 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 65 439 2.9E-96 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 TIGRFAM TIGR02353 NRPS_term_dom: non-ribosomal peptide synthetase terminal domain of unknown function 614 1299 3.5E-225 T 17-03-2017 IPR012728 Non-ribosomal peptide synthetase, C-terminal SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:1.10.1200.10 523 596 2.1E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 SUPERFAMILY SSF47336 523 592 4.06E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:2.160.10.10 952 992 1.1E-25 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:2.160.10.10 1219 1304 1.1E-25 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 Gene3D G3DSA:2.160.10.10 729 837 1.1E-16 T 17-03-2017 SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 SUPERFAMILY SSF51161 897 1060 3.77E-11 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 ProSitePatterns PS00455 Putative AMP-binding domain signature. 168 179 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS06235 da3038ef96496405cb30cddb21c78886 1318 SUPERFAMILY SSF51161 721 830 8.87E-19 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS29770 ce021dfbfb0a4a7876415c0b1fac794a 336 Pfam PF03734 L,D-transpeptidase catalytic domain 184 305 2.5E-15 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS29770 ce021dfbfb0a4a7876415c0b1fac794a 336 Gene3D G3DSA:2.40.440.10 186 306 3.2E-21 T 17-03-2017 SHXM_RS29770 ce021dfbfb0a4a7876415c0b1fac794a 336 SUPERFAMILY SSF141523 186 305 3.92E-29 T 17-03-2017 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 Hamap MF_00104 Ribonuclease 3 [rnc]. 26 239 30.364 T 17-03-2017 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 Reactome: R-HSA-203927 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 SMART SM00358 177 243 3.0E-24 T 17-03-2017 IPR014720 Double-stranded RNA-binding domain SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 TIGRFAM TIGR02191 RNaseIII: ribonuclease III 28 241 1.7E-72 T 17-03-2017 IPR011907 Ribonuclease III GO:0003723|GO:0004525|GO:0016075 Reactome: R-HSA-203927 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 ProSitePatterns PS00517 Ribonuclease III family signature. 59 67 - T 17-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 Pfam PF00035 Double-stranded RNA binding motif 177 240 6.2E-18 T 17-03-2017 IPR014720 Double-stranded RNA-binding domain SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 Pfam PF14622 Ribonuclease-III-like 36 161 1.6E-37 T 17-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 SMART SM00535 37 170 6.9E-60 T 17-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 Gene3D G3DSA:1.10.1520.10 26 167 1.7E-45 T 17-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 SUPERFAMILY SSF54768 131 243 2.36E-26 T 17-03-2017 SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 Gene3D G3DSA:3.30.160.20 175 242 1.7E-25 T 17-03-2017 IPR014720 Double-stranded RNA-binding domain SHXM_RS36455 12aee9175e61ab5fc1feac12163f317f 278 SUPERFAMILY SSF69065 18 179 8.89E-49 T 17-03-2017 IPR000999 Ribonuclease III domain GO:0004525|GO:0006396 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF51735 2274 2447 1.54E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00823 Phosphopantetheine attachment site 1280 1352 2.5E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.50.720 1008 1187 8.9E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 293 409 3.8E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1745 1862 1.0E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1625 1742 8.6E-46 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 173 290 5.5E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF08659 KR domain 1009 1183 2.3E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF08659 KR domain 2460 2631 4.0E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00825 Beta-ketoacyl synthase 1374 1795 2.3E-217 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00825 Beta-ketoacyl synthase 1 343 5.2E-158 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1889 2173 5.4E-115 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 436 720 3.4E-116 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 78 94 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.50.720 2460 2630 1.4E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 165 2.1E-60 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1372 1617 5.1E-87 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF52151 2066 2161 2.88E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF52151 1887 2007 2.88E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF52151 621 708 1.02E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF52151 434 560 1.02E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF51735 1007 1242 1.15E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.47.10 178 343 2.8E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.47.10 1630 1795 6.7E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF53901 1 280 2.81E-78 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:1.10.1200.10 1277 1352 2.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF53901 1369 1740 1.67E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM01294 1281 1348 3.8E-6 T 17-03-2017 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.30.70.250 2012 2072 3.7E-7 T 17-03-2017 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.30.70.250 559 619 7.2E-7 T 17-03-2017 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.47.10 1 177 1.4E-68 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.47.10 1374 1629 8.9E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF51735 821 995 8.66E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF51735 2459 2630 8.54E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.366.10 2073 2161 2.3E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.366.10 433 554 2.8E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.366.10 620 709 2.8E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Gene3D G3DSA:3.40.366.10 1886 2007 2.3E-71 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF00698 Acyl transferase domain 436 706 1.4E-51 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF00698 Acyl transferase domain 1889 2159 5.4E-51 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1530 1546 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF47336 1275 1386 3.01E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF55048 559 620 2.35E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SUPERFAMILY SSF55048 2012 2073 1.83E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2460 2630 4.3E-50 T 17-03-2017 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1009 1185 6.3E-42 T 17-03-2017 SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 Pfam PF00550 Phosphopantetheine attachment site 1283 1348 3.2E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05370 6967c9331ceb726fed1866d8bf310151 2631 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1307 1322 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 SUPERFAMILY SSF53850 75 413 9.24E-58 T 17-03-2017 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 Gene3D G3DSA:3.40.190.10 77 201 4.2E-7 T 17-03-2017 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 153 166 5.3E-7 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 230 249 5.3E-7 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 269 288 5.3E-7 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 137 151 5.3E-7 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 313 332 5.3E-7 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 Pfam PF13416 Bacterial extracellular solute-binding protein 100 379 7.1E-24 T 17-03-2017 SHXM_RS36775 b58c108820e65a72b25827f5da15b172 416 Gene3D G3DSA:3.40.190.10 202 362 8.1E-38 T 17-03-2017 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 SUPERFAMILY SSF53244 400 557 4.97E-43 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 SUPERFAMILY SSF63418 74 163 3.01E-20 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Pfam PF01225 Mur ligase family, catalytic domain 86 160 2.7E-12 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Gene3D G3DSA:3.40.1190.10 168 403 4.1E-76 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 TIGRFAM TIGR01085 murE: UDP-N-acetylmuramyl-tripeptide synthetase 85 557 5.4E-140 T 17-03-2017 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Hamap MF_00208 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [murE]. 64 557 32.889 T 17-03-2017 IPR005761 UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase GO:0005524|GO:0005737|GO:0008360|GO:0016881|GO:0051301 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 SUPERFAMILY SSF53623 165 399 1.57E-64 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Pfam PF08245 Mur ligase middle domain 174 379 1.0E-49 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Gene3D G3DSA:3.90.190.20 404 551 4.0E-48 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Pfam PF02875 Mur ligase family, glutamate ligase domain 400 484 3.7E-18 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS18590 a91992dc8c0b3f51fa939abefa776475 586 Gene3D G3DSA:3.40.1390.10 70 163 1.6E-21 T 17-03-2017 IPR000713 Mur ligase, N-terminal catalytic domain GO:0005524|GO:0009058 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 Gene3D G3DSA:3.30.160.20 227 305 1.3E-35 T 17-03-2017 IPR014720 Double-stranded RNA-binding domain SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 244 260 - T 17-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 SUPERFAMILY SSF75620 30 366 1.83E-122 T 17-03-2017 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 Hamap MF_00094 Peptide chain release factor 2 [prfB]. 2 364 38.163 T 17-03-2017 IPR020853 Peptide chain release factor 2, bacterial GO:0005737|GO:0006415|GO:0016149 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 SMART SM00937 84 194 2.1E-42 T 17-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 Pfam PF00472 RF-1 domain 228 336 5.5E-38 T 17-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 Pfam PF03462 PCRF domain 30 219 6.4E-55 T 17-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 Gene3D G3DSA:1.20.58.410 5 115 8.3E-33 T 17-03-2017 SHXM_RS23865 f39502046929e98fcf325e1172492c43 370 TIGRFAM TIGR00020 prfB: peptide chain release factor 2 4 363 1.8E-155 T 17-03-2017 IPR004374 Peptide chain release factor 2 GO:0005737|GO:0006415|GO:0016149 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 362 382 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 5 252 1.5E-81 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 SUPERFAMILY SSF53067 5 255 2.59E-97 T 17-03-2017 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 Gene3D G3DSA:3.30.420.40 254 497 2.8E-90 T 17-03-2017 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 SUPERFAMILY SSF53067 255 496 2.96E-76 T 17-03-2017 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 5 496 8.5E-210 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 Gene3D G3DSA:3.30.420.40 2 253 5.1E-106 T 17-03-2017 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 Hamap MF_00186 Glycerol kinase [glpK]. 3 497 56.965 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 135 147 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 262 450 4.0E-52 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS42180 1c379ca3b4d4869eba1621b3b9adebf7 499 PIRSF PIRSF000538 3 499 4.0E-185 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 5.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 5.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 5.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 Gene3D G3DSA:3.40.50.720 16 254 1.6E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 SUPERFAMILY SSF51735 232 285 1.0E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 SUPERFAMILY SSF51735 16 199 1.0E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 Pfam PF00106 short chain dehydrogenase 16 192 2.3E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 14 187 0.0036 T 17-03-2017 SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 8.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 8.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 15 32 8.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 8.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13360 3a9318db18968a22c4869445fc0ba9df 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 8.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.30.470.20 750 952 1.1E-60 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.30.470.20 206 405 3.7E-77 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SUPERFAMILY SSF52440 2 127 4.17E-47 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SUPERFAMILY SSF52440 558 678 6.62E-43 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SUPERFAMILY SSF56059 128 406 1.71E-99 T 17-03-2017 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SMART SM00851 974 1065 3.1E-28 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SUPERFAMILY SSF52335 960 1094 1.44E-32 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 682 879 2.9E-30 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 128 340 7.8E-66 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 TIGRFAM TIGR01369 CPSaseII_lrg: carbamoyl-phosphate synthase, large subunit 2 1074 0.0 T 17-03-2017 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SUPERFAMILY SSF56059 678 951 1.01E-87 T 17-03-2017 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 303 310 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 170 184 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Pfam PF02142 MGS-like domain 975 1065 3.7E-21 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:1.10.1030.10 406 538 1.8E-44 T 17-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Hamap MF_01210_B Carbamoyl-phosphate synthase large chain [carB]. 1 1086 12.943 T 17-03-2017 IPR006275 Carbamoyl-phosphate synthase, large subunit GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 842 849 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 245 262 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 303 332 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 19 33 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 48 58 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 210 229 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 385 403 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 PRINTS PR00098 Carbamoyl-phosphate synthase protein CPSase domain signature 174 186 2.2E-63 T 17-03-2017 IPR005483 Carbamoyl-phosphate synthase large subunit, CPSase domain GO:0006807 KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.40.50.20 539 666 7.7E-57 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SMART SM01096 426 547 2.6E-57 T 17-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.30.1490.20 149 205 1.4E-19 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.30.1490.20 690 749 2.6E-23 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.40.50.20 3 107 1.0E-42 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Pfam PF02787 Carbamoyl-phosphate synthetase large chain, oligomerisation domain 431 547 2.2E-36 T 17-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 713 727 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 SUPERFAMILY SSF48108 401 554 1.44E-45 T 17-03-2017 IPR005480 Carbamoyl-phosphate synthetase, large subunit oligomerisation domain KEGG: 00240+6.3.5.5|KEGG: 00250+6.3.5.5|MetaCyc: PWY-5154|MetaCyc: PWY-5686|MetaCyc: PWY-7400 SHXM_RS12355 d7b906cda44f7c3ed8e6e7b12acedaae 1103 Gene3D G3DSA:3.40.50.1380 957 1096 3.5E-40 T 17-03-2017 IPR011607 Methylglyoxal synthase-like domain SHXM_RS22995 6c1409ea0ecc9d741ec3b758ebd5938d 216 SUPERFAMILY SSF161098 14 200 1.19E-40 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22995 6c1409ea0ecc9d741ec3b758ebd5938d 216 TIGRFAM TIGR03003 ectoine_ehuD: ectoine/hydroxyectoine ABC transporter, permease protein EhuD 3 214 1.7E-84 T 17-03-2017 IPR014341 Ectoine/hydroxyectoine ABC transporter, permease protein EhuD SHXM_RS22995 6c1409ea0ecc9d741ec3b758ebd5938d 216 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 35 214 5.1E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22995 6c1409ea0ecc9d741ec3b758ebd5938d 216 Gene3D G3DSA:1.10.3720.10 12 214 1.3E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22995 6c1409ea0ecc9d741ec3b758ebd5938d 216 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 12 109 3.2E-30 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS01995 815ea350da48fa358c2dec588200e408 348 SUPERFAMILY SSF51430 4 317 8.9E-97 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS01995 815ea350da48fa358c2dec588200e408 348 PRINTS PR00069 Aldo-keto reductase signature 107 125 1.5E-7 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS01995 815ea350da48fa358c2dec588200e408 348 PRINTS PR00069 Aldo-keto reductase signature 138 155 1.5E-7 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS01995 815ea350da48fa358c2dec588200e408 348 PRINTS PR00069 Aldo-keto reductase signature 42 66 1.5E-7 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS01995 815ea350da48fa358c2dec588200e408 348 Pfam PF00248 Aldo/keto reductase family 16 317 1.4E-76 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS01995 815ea350da48fa358c2dec588200e408 348 Gene3D G3DSA:3.20.20.100 3 318 2.6E-97 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS22215 beb694f3325ee5d3be6c1547e1e3a5ae 253 Gene3D G3DSA:3.40.50.1820 10 245 2.3E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22215 beb694f3325ee5d3be6c1547e1e3a5ae 253 Pfam PF00975 Thioesterase domain 23 244 6.4E-53 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS22215 beb694f3325ee5d3be6c1547e1e3a5ae 253 SMART SM00824 Thioesterase 25 248 5.1E-4 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS22215 beb694f3325ee5d3be6c1547e1e3a5ae 253 SUPERFAMILY SSF53474 9 248 4.55E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 ProSitePatterns PS00174 Phosphoglucose isomerase signature 2. 497 514 - T 17-03-2017 IPR018189 Phosphoglucose isomerase, conserved site GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 Hamap MF_00473 Glucose-6-phosphate isomerase [pgi]. 48 524 41.016 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 SUPERFAMILY SSF53697 9 548 3.61E-206 T 17-03-2017 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 Gene3D G3DSA:3.40.50.10490 149 187 1.9E-155 T 17-03-2017 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 Gene3D G3DSA:3.40.50.10490 267 501 1.9E-155 T 17-03-2017 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 Gene3D G3DSA:3.40.50.10490 8 104 1.9E-155 T 17-03-2017 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 Gene3D G3DSA:1.10.1390.10 502 548 1.7E-19 T 17-03-2017 IPR023096 Phosphoglucose isomerase, C-terminal GO:0004347|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 PRINTS PR00662 Glucose-6-phosphate isomerase signature 152 171 3.7E-54 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 PRINTS PR00662 Glucose-6-phosphate isomerase signature 483 497 3.7E-54 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 PRINTS PR00662 Glucose-6-phosphate isomerase signature 265 283 3.7E-54 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 PRINTS PR00662 Glucose-6-phosphate isomerase signature 497 510 3.7E-54 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 PRINTS PR00662 Glucose-6-phosphate isomerase signature 465 483 3.7E-54 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 PRINTS PR00662 Glucose-6-phosphate isomerase signature 342 363 3.7E-54 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17895 6c423cab220e5e2936b11497fc174064 550 Pfam PF00342 Phosphoglucose isomerase 54 541 8.6E-216 T 17-03-2017 IPR001672 Phosphoglucose isomerase (PGI) GO:0004347|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|Reactome: R-HSA-5628897|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS03900 85951cf9347c33dcc61dd0791f89ecd7 437 Gene3D G3DSA:3.40.190.10 168 357 2.2E-38 T 17-03-2017 SHXM_RS03900 85951cf9347c33dcc61dd0791f89ecd7 437 SUPERFAMILY SSF53850 27 426 3.32E-53 T 17-03-2017 SHXM_RS03900 85951cf9347c33dcc61dd0791f89ecd7 437 Gene3D G3DSA:3.40.190.10 89 167 1.2E-7 T 17-03-2017 SHXM_RS03900 85951cf9347c33dcc61dd0791f89ecd7 437 Pfam PF13416 Bacterial extracellular solute-binding protein 73 357 1.9E-28 T 17-03-2017 SHXM_RS49165 8dcc9775e851eb2270bcd24aee6b8c3b 271 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 72 262 1.3E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49165 8dcc9775e851eb2270bcd24aee6b8c3b 271 SUPERFAMILY SSF161098 39 257 1.22E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49165 8dcc9775e851eb2270bcd24aee6b8c3b 271 Gene3D G3DSA:1.10.3720.10 45 265 1.5E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06060 ccb947a6d4073dc814c38c33727ec3f5 518 Gene3D G3DSA:3.10.105.10 288 484 2.1E-41 T 17-03-2017 SHXM_RS06060 ccb947a6d4073dc814c38c33727ec3f5 518 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 85 421 4.8E-70 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS06060 ccb947a6d4073dc814c38c33727ec3f5 518 PIRSF PIRSF002741 6 497 6.3E-70 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS06060 ccb947a6d4073dc814c38c33727ec3f5 518 SUPERFAMILY SSF53850 39 514 1.25E-106 T 17-03-2017 SHXM_RS06060 ccb947a6d4073dc814c38c33727ec3f5 518 Gene3D G3DSA:3.40.190.10 144 287 1.5E-35 T 17-03-2017 SHXM_RS40960 8ecfa3f2a54a95ae28620425fb9d8f24 371 Gene3D G3DSA:3.40.350.10 10 142 1.0E-20 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS40960 8ecfa3f2a54a95ae28620425fb9d8f24 371 Pfam PF01321 Creatinase/Prolidase N-terminal domain 11 143 9.1E-20 T 17-03-2017 IPR000587 Creatinase, N-terminal GO:0016787 SHXM_RS40960 8ecfa3f2a54a95ae28620425fb9d8f24 371 Gene3D G3DSA:3.90.230.10 145 369 1.4E-66 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS40960 8ecfa3f2a54a95ae28620425fb9d8f24 371 SUPERFAMILY SSF53092 9 142 4.71E-22 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS40960 8ecfa3f2a54a95ae28620425fb9d8f24 371 Pfam PF00557 Metallopeptidase family M24 151 354 1.9E-54 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS40960 8ecfa3f2a54a95ae28620425fb9d8f24 371 SUPERFAMILY SSF55920 144 370 1.31E-69 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS42330 274da698c44db4fff1dc4d436b19d0c0 159 SUPERFAMILY SSF46785 1 136 2.65E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42330 274da698c44db4fff1dc4d436b19d0c0 159 Gene3D G3DSA:1.10.10.10 2 140 3.5E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42330 274da698c44db4fff1dc4d436b19d0c0 159 Pfam PF02082 Transcriptional regulator 2 82 8.4E-19 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS23685 d05494410d1a0e17ad5a7f772c6d8441 195 SUPERFAMILY SSF143456 4 189 2.49E-46 T 17-03-2017 SHXM_RS23685 d05494410d1a0e17ad5a7f772c6d8441 195 Gene3D G3DSA:3.40.1740.10 136 182 9.7E-29 T 17-03-2017 SHXM_RS23685 d05494410d1a0e17ad5a7f772c6d8441 195 Gene3D G3DSA:3.40.1740.10 2 44 9.7E-29 T 17-03-2017 SHXM_RS23685 d05494410d1a0e17ad5a7f772c6d8441 195 Pfam PF02622 Uncharacterized ACR, COG1678 16 178 2.3E-36 T 17-03-2017 IPR003774 Protein of unknown function UPF0301 SHXM_RS23685 d05494410d1a0e17ad5a7f772c6d8441 195 Hamap MF_00758 UPF0301 protein YqgE [yqgE]. 5 192 26.491 T 17-03-2017 IPR003774 Protein of unknown function UPF0301 SHXM_RS28225 60e17c8e78f33ba3350954db79a661ab 225 TIGRFAM TIGR01076 sortase_fam: sortase 87 208 1.5E-12 T 17-03-2017 IPR005754 Sortase family SHXM_RS28225 60e17c8e78f33ba3350954db79a661ab 225 Gene3D G3DSA:2.40.260.10 72 213 2.3E-23 T 17-03-2017 IPR023365 Sortase domain SHXM_RS28225 60e17c8e78f33ba3350954db79a661ab 225 Pfam PF04203 Sortase family 78 209 1.2E-25 T 17-03-2017 IPR005754 Sortase family SHXM_RS28225 60e17c8e78f33ba3350954db79a661ab 225 SUPERFAMILY SSF63817 65 212 9.68E-30 T 17-03-2017 IPR023365 Sortase domain SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 Pfam PF00155 Aminotransferase class I and II 44 398 3.1E-75 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 SUPERFAMILY SSF53383 16 408 4.03E-114 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 Gene3D G3DSA:3.40.640.10 56 286 3.5E-76 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 211 234 9.0E-11 T 17-03-2017 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 128 149 9.0E-11 T 17-03-2017 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 242 266 9.0E-11 T 17-03-2017 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 175 199 9.0E-11 T 17-03-2017 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 Gene3D G3DSA:3.90.1150.10 287 408 5.0E-37 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS31065 53df44939783752f3df58a486d4ad1c4 412 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 248 261 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 SMART SM01086 756 845 2.4E-35 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 SUPERFAMILY SSF52540 527 846 7.43E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 656 674 4.2E-41 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 582 600 4.2E-41 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 627 645 4.2E-41 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 689 703 4.2E-41 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Gene3D G3DSA:3.40.50.300 739 765 1.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Gene3D G3DSA:3.40.50.300 531 704 1.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 612 630 - T 17-03-2017 IPR028299 ClpA/B, conserved site 2 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Gene3D G3DSA:1.10.8.60 389 471 1.5E-33 T 17-03-2017 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 130 169 2.9E-10 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 59 108 9.7E-5 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 SUPERFAMILY SSF52540 200 473 2.96E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 756 836 7.9E-24 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 338 350 - T 17-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Gene3D G3DSA:3.40.50.300 201 386 3.4E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Gene3D G3DSA:1.10.1780.10 48 167 6.0E-23 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Gene3D G3DSA:1.10.8.60 766 851 2.6E-29 T 17-03-2017 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Pfam PF07724 AAA domain (Cdc48 subfamily) 577 750 4.5E-51 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 244 360 2.3E-11 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 SUPERFAMILY SSF81923 48 157 3.92E-16 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 Pfam PF02151 UvrB/uvrC motif 460 492 2.8E-6 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 SMART SM00382 239 387 1.5E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS06495 d86934b5e0bd4b84b4f9a6e056444170 889 SMART SM00382 578 735 1.6E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 194 290 8.8E-27 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 418 497 1.8E-11 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 14 192 5.2E-59 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 Gene3D G3DSA:3.40.50.720 14 195 3.8E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 SUPERFAMILY SSF51735 14 193 6.68E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 Gene3D G3DSA:1.10.1040.10 196 290 3.0E-26 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 Gene3D G3DSA:1.10.1040.10 418 497 2.4E-13 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 SUPERFAMILY SSF48179 193 298 3.57E-26 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS28355 a47edc9c600b9967bc152a00bee252e8 505 SUPERFAMILY SSF48179 417 501 3.83E-14 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS05410 88720a9faf51f0f43d45b86162afd925 186 SUPERFAMILY SSF46689 3 61 7.18E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05410 88720a9faf51f0f43d45b86162afd925 186 SUPERFAMILY SSF48498 70 169 1.42E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS05410 88720a9faf51f0f43d45b86162afd925 186 Gene3D G3DSA:1.10.357.10 3 179 4.6E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS05410 88720a9faf51f0f43d45b86162afd925 186 Pfam PF00440 Bacterial regulatory proteins, tetR family 2 46 4.1E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05410 88720a9faf51f0f43d45b86162afd925 186 Pfam PF13977 Bacterial transcriptional repressor 74 182 9.1E-7 T 17-03-2017 SHXM_RS32825 f3ea23bde83ca7176aca98707616d131 162 Pfam PF14433 SUKH-3 immunity protein 9 153 7.6E-48 T 17-03-2017 IPR025850 SUKH-3 immunity protein SHXM_RS03585 e63a8ad27b1fc38e3f53c93cdfac1ab4 380 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 55 350 2.7E-55 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS03585 e63a8ad27b1fc38e3f53c93cdfac1ab4 380 Gene3D G3DSA:1.20.1510.10 55 267 1.0E-31 T 17-03-2017 IPR027469 Cation efflux protein transmembrane domain SHXM_RS03585 e63a8ad27b1fc38e3f53c93cdfac1ab4 380 Pfam PF01545 Cation efflux family 57 267 4.0E-35 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS03585 e63a8ad27b1fc38e3f53c93cdfac1ab4 380 SUPERFAMILY SSF161111 53 269 5.75E-35 T 17-03-2017 SHXM_RS46685 c5ce5a06023d7105b31a37b192d1a87f 332 Gene3D G3DSA:3.20.20.150 4 328 1.7E-70 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS46685 c5ce5a06023d7105b31a37b192d1a87f 332 Pfam PF07582 AP endonuclease family 2 C terminus 287 327 6.1E-7 T 17-03-2017 IPR011418 AP endonuclease, family 2, C-terminal SHXM_RS46685 c5ce5a06023d7105b31a37b192d1a87f 332 Pfam PF01261 Xylose isomerase-like TIM barrel 21 231 1.0E-29 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS46685 c5ce5a06023d7105b31a37b192d1a87f 332 SUPERFAMILY SSF51658 273 327 8.29E-46 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS46685 c5ce5a06023d7105b31a37b192d1a87f 332 SUPERFAMILY SSF51658 3 228 8.29E-46 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF00550 Phosphopantetheine attachment site 1665 1731 6.1E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 571 870 7.6E-112 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 288 405 7.9E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:3.40.50.720 1379 1588 2.1E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF14765 Polyketide synthase dehydratase 937 1196 4.3E-24 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF51735 1204 1364 8.46E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:1.10.1200.10 1660 1735 8.7E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:3.40.47.10 294 458 2.2E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 31 280 2.0E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SMART SM00823 Phosphopantetheine attachment site 1663 1735 2.0E-25 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SMART SM00826 937 1098 2.4E-43 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF52151 761 856 3.4E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF52151 567 696 3.4E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF08659 KR domain 1380 1558 2.4E-50 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 408 517 5.2E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:3.40.47.10 33 292 1.2E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF51735 1378 1632 4.76E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF47336 1654 1739 2.62E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:3.30.70.250 695 759 9.7E-7 T 17-03-2017 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:3.40.366.10 562 691 7.6E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Gene3D G3DSA:3.40.366.10 760 884 7.6E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1380 1560 5.3E-53 T 17-03-2017 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF55048 695 760 2.09E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SMART SM00825 Beta-ketoacyl synthase 33 458 3.1E-217 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 193 209 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 Pfam PF00698 Acyl transferase domain 569 889 1.4E-83 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS39615 dd3ca97223fc6f194f78cde2e4a2a043 1818 SUPERFAMILY SSF53901 28 402 4.52E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS21145 465537ebbc3ebbf1b99da61ee90db350 157 SUPERFAMILY SSF69118 17 152 7.2E-39 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS21145 465537ebbc3ebbf1b99da61ee90db350 157 Gene3D G3DSA:1.20.1290.10 17 152 4.0E-47 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS21145 465537ebbc3ebbf1b99da61ee90db350 157 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 30 80 2.9E-20 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS21145 465537ebbc3ebbf1b99da61ee90db350 157 Pfam PF02627 Carboxymuconolactone decarboxylase family 21 95 8.3E-21 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 SUPERFAMILY SSF52518 5 330 3.05E-93 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 Gene3D G3DSA:3.40.50.920 550 675 3.3E-41 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 Pfam PF02780 Transketolase, C-terminal domain 561 663 4.4E-7 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 6 335 2.4E-113 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 ProSitePatterns PS00802 Transketolase signature 2. 479 495 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 Gene3D G3DSA:3.40.50.970 5 330 7.6E-100 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 Gene3D G3DSA:3.40.50.970 349 547 3.3E-63 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 SUPERFAMILY SSF52922 545 676 7.98E-36 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 SMART SM00861 360 536 5.0E-57 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 Pfam PF02779 Transketolase, pyrimidine binding domain 360 535 2.0E-38 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS00855 acbd9d262a26f347a188db1990837adb 680 SUPERFAMILY SSF52518 351 537 3.59E-58 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 SUPERFAMILY SSF55729 183 365 5.11E-39 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 SUPERFAMILY SSF55729 5 114 1.01E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 SUPERFAMILY SSF55729 143 194 1.01E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 Gene3D G3DSA:3.40.630.30 184 345 2.2E-53 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 Pfam PF02388 FemAB family 8 248 4.3E-30 T 17-03-2017 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 Pfam PF02388 FemAB family 265 365 2.5E-17 T 17-03-2017 IPR003447 FemABX peptidyl transferase GO:0009252|GO:0016755 SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 Gene3D G3DSA:3.40.630.30 1 116 5.5E-56 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28000 fa6847a5a413797df2f331baf7d7aeed 372 Gene3D G3DSA:3.40.630.30 148 183 5.5E-56 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS14555 0634dc533794627d2f23b21c73d88ab9 241 SUPERFAMILY SSF63817 90 237 4.97E-15 T 17-03-2017 IPR023365 Sortase domain SHXM_RS14555 0634dc533794627d2f23b21c73d88ab9 241 Pfam PF04203 Sortase family 96 235 2.1E-15 T 17-03-2017 IPR005754 Sortase family SHXM_RS14555 0634dc533794627d2f23b21c73d88ab9 241 Gene3D G3DSA:2.40.260.10 95 237 2.6E-9 T 17-03-2017 IPR023365 Sortase domain SHXM_RS33220 bf7da8fe17fa26e465fa980a667724f8 290 SUPERFAMILY SSF102588 4 288 2.35E-76 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS33220 bf7da8fe17fa26e465fa980a667724f8 290 TIGRFAM TIGR03446 mycothiol_Mca: mycothiol conjugate amidase Mca 5 287 4.9E-152 T 17-03-2017 IPR017811 Mycothiol S-conjugate amidase Mca GO:0010126 KEGG: 00311+3.5.1.11 SHXM_RS33220 bf7da8fe17fa26e465fa980a667724f8 290 Hamap MF_01482 Mycothiol S-conjugate amidase [mca]. 8 288 52.825 T 17-03-2017 IPR017811 Mycothiol S-conjugate amidase Mca GO:0010126 KEGG: 00311+3.5.1.11 SHXM_RS33220 bf7da8fe17fa26e465fa980a667724f8 290 Pfam PF02585 GlcNAc-PI de-N-acetylase 8 154 1.8E-25 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS33220 bf7da8fe17fa26e465fa980a667724f8 290 Gene3D G3DSA:3.40.50.10320 3 288 7.9E-88 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS36040 b4817a23bffc25a755b53a5600189f33 303 Pfam PF00296 Luciferase-like monooxygenase 15 263 4.6E-50 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS36040 b4817a23bffc25a755b53a5600189f33 303 SUPERFAMILY SSF51679 1 270 1.02E-57 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS36040 b4817a23bffc25a755b53a5600189f33 303 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 22 278 3.1E-61 T 17-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted SHXM_RS36040 b4817a23bffc25a755b53a5600189f33 303 Gene3D G3DSA:3.20.20.30 1 267 3.6E-67 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 126 229 2.9E-21 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 11 122 8.2E-32 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 SUPERFAMILY SSF47203 243 397 1.94E-53 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 Gene3D G3DSA:1.20.140.10 231 398 2.9E-60 T 17-03-2017 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 Gene3D G3DSA:2.40.110.10 125 230 1.2E-33 T 17-03-2017 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 Gene3D G3DSA:1.10.540.10 9 123 1.1E-37 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 SUPERFAMILY SSF56645 9 252 1.44E-72 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 244 393 2.8E-46 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS14750 30da23fc933b1167fb5a03ea5063b475 400 PIRSF PIRSF016578 5 396 1.3E-16 T 17-03-2017 SHXM_RS16920 f015ba071f043adbb1172bf7416cb29d 253 SMART SM00382 29 226 7.2E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS16920 f015ba071f043adbb1172bf7416cb29d 253 PIRSF PIRSF039085 1 253 4.7E-116 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS16920 f015ba071f043adbb1172bf7416cb29d 253 Pfam PF00005 ABC transporter 20 178 2.0E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS16920 f015ba071f043adbb1172bf7416cb29d 253 Gene3D G3DSA:3.40.50.300 4 250 2.1E-82 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16920 f015ba071f043adbb1172bf7416cb29d 253 SUPERFAMILY SSF52540 4 248 9.53E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16920 f015ba071f043adbb1172bf7416cb29d 253 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 PIRSF PIRSF001586 1 226 6.6E-84 T 17-03-2017 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 SMART SM01211 2 223 4.2E-119 T 17-03-2017 SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 Gene3D G3DSA:3.40.50.880 3 221 1.2E-39 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 Hamap MF_00421 Phosphoribosylformylglycinamidine synthase subunit PurQ [purQ]. 3 221 40.296 T 17-03-2017 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 Pfam PF13507 CobB/CobQ-like glutamine amidotransferase domain 4 204 1.4E-33 T 17-03-2017 SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 SUPERFAMILY SSF52317 3 221 1.53E-66 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS29390 6c79fdd501c02f70f0e714e90dea65ac 226 TIGRFAM TIGR01737 FGAM_synth_I: phosphoribosylformylglycinamidine synthase I 4 221 4.6E-83 T 17-03-2017 IPR010075 Phosphoribosylformylglycinamidine synthase subunit PurQ GO:0004642|GO:0005737|GO:0006189 KEGG: 00220+3.5.1.2|KEGG: 00230+6.3.5.3|KEGG: 00250+3.5.1.2|KEGG: 00471+3.5.1.2|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 PRINTS PR00974 Ribosomal protein S18 family signature 63 73 4.8E-16 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 PRINTS PR00974 Ribosomal protein S18 family signature 31 41 4.8E-16 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 PRINTS PR00974 Ribosomal protein S18 family signature 41 48 4.8E-16 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 PRINTS PR00974 Ribosomal protein S18 family signature 49 63 4.8E-16 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 Hamap MF_00270 30S ribosomal protein S18 [rpsR]. 3 76 20.759 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 Gene3D G3DSA:4.10.640.10 11 75 1.4E-32 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 ProSitePatterns PS00057 Ribosomal protein S18 signature. 24 47 - T 17-03-2017 IPR018275 Ribosomal protein S18, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 TIGRFAM TIGR00165 S18: ribosomal protein bS18 9 75 3.5E-30 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 Pfam PF01084 Ribosomal protein S18 21 71 4.5E-24 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 ProDom PD002239 RIBOSOMAL S18 RIBONUCLEOPROTEIN 30S RRNA-BINDING RNA-BINDING CHLOROPLAST PLASTID MITOCHONDRIAL ACETYLATION 23 73 6.0E-24 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS27980 4ffc663cab710c493b36e79c3661076a 78 SUPERFAMILY SSF46911 5 75 1.44E-28 T 17-03-2017 IPR001648 Ribosomal protein S18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS23210 b5490df6459f8c86e6780d05fb35f7c8 180 Gene3D G3DSA:1.10.10.10 1 84 2.3E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23210 b5490df6459f8c86e6780d05fb35f7c8 180 SUPERFAMILY SSF46785 2 172 1.77E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23210 b5490df6459f8c86e6780d05fb35f7c8 180 Pfam PF10400 Virulence activator alpha C-term 90 170 1.5E-11 T 17-03-2017 IPR018309 Transcription regulator PadR, C-terminal SHXM_RS23210 b5490df6459f8c86e6780d05fb35f7c8 180 Pfam PF03551 Transcriptional regulator PadR-like family 7 79 4.8E-12 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 Pfam PF01595 Domain of unknown function DUF21 9 185 5.7E-31 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 SMART SM01091 337 428 2.0E-13 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 Gene3D G3DSA:3.30.465.10 330 427 1.2E-20 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 SMART SM00116 209 258 0.0052 T 17-03-2017 IPR000644 CBS domain SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 SMART SM00116 274 322 1.6 T 17-03-2017 IPR000644 CBS domain SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 SUPERFAMILY SSF54631 195 340 1.77E-34 T 17-03-2017 SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 Pfam PF00571 CBS domain 200 256 2.0E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 Pfam PF00571 CBS domain 273 322 4.2E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 Pfam PF03471 Transporter associated domain 339 427 1.8E-12 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 Gene3D G3DSA:3.10.580.10 186 329 8.1E-23 T 17-03-2017 SHXM_RS21245 58667813e87df45b98e7196e1f15cb02 436 SUPERFAMILY SSF56176 335 431 1.17E-12 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS07305 80aff6ecfd491f0c90fff9658a93627d 216 Pfam PF02570 Precorrin-8X methylmutase 16 213 4.3E-71 T 17-03-2017 IPR003722 Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase GO:0009236|GO:0016993 SHXM_RS07305 80aff6ecfd491f0c90fff9658a93627d 216 Gene3D G3DSA:3.40.50.10230 6 212 5.3E-79 T 17-03-2017 IPR003722 Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase GO:0009236|GO:0016993 SHXM_RS07305 80aff6ecfd491f0c90fff9658a93627d 216 SUPERFAMILY SSF63965 7 213 6.54E-71 T 17-03-2017 IPR003722 Cobalamin (vitamin B12) biosynthesis CobH/CbiC, precorrin-8X methylmutase GO:0009236|GO:0016993 SHXM_RS42755 3ae2a648b36b07d0da929bab759e119e 127 Gene3D G3DSA:1.10.10.10 26 109 3.2E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42755 3ae2a648b36b07d0da929bab759e119e 127 SUPERFAMILY SSF46785 18 109 1.66E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42755 3ae2a648b36b07d0da929bab759e119e 127 SMART SM00418 31 109 4.0E-11 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS42755 3ae2a648b36b07d0da929bab759e119e 127 Pfam PF12840 Helix-turn-helix domain 31 84 2.4E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42755 3ae2a648b36b07d0da929bab759e119e 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 33 48 1.1E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS42755 3ae2a648b36b07d0da929bab759e119e 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 65 80 1.1E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 SUPERFAMILY SSF51905 291 397 1.21E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 SUPERFAMILY SSF51905 5 184 1.21E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 294 309 2.7E-10 T 17-03-2017 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 7 29 2.7E-10 T 17-03-2017 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 157 172 2.7E-10 T 17-03-2017 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 TIGRFAM TIGR02032 GG-red-SF: geranylgeranyl reductase family 7 329 2.1E-89 T 17-03-2017 IPR011777 Geranylgeranyl reductase family GO:0016628|GO:0055114 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 Gene3D G3DSA:3.30.9.10 174 337 1.9E-52 T 17-03-2017 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 Pfam PF01494 FAD binding domain 6 185 9.8E-13 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS30735 eeda7843a382d1f1a4f619a37cb2e253 423 Gene3D G3DSA:3.50.50.60 4 173 9.0E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF47336 1721 1834 2.62E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM01294 3486 3553 1.8E-6 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM01294 5239 5306 1.1E-5 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM01294 7045 7112 6.9E-6 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM01294 1728 1795 1.0E-6 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 299 464 3.5E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 3839 4004 4.5E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 5592 5758 2.1E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 2083 2249 1.2E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00826 6222 6393 6.4E-80 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00826 2714 2877 3.1E-87 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00826 4473 4636 1.7E-88 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00826 938 1101 3.3E-88 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 5326 5591 2.5E-94 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 3573 3838 1.1E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF14765 Polyketide synthase dehydratase 938 1211 5.8E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF14765 Polyketide synthase dehydratase 6222 6506 2.5E-54 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF14765 Polyketide synthase dehydratase 4473 4746 2.0E-57 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF14765 Polyketide synthase dehydratase 2714 2987 5.5E-56 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF47336 7037 7121 2.09E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF08990 Erythronolide synthase docking 4 29 3.5E-10 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 294 411 1.0E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2078 2195 6.2E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 3834 3951 3.9E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 5587 5704 3.9E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 286 5.6E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5329 5579 2.5E-94 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1819 2070 1.2E-95 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 3576 3826 5.2E-93 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 1221 1423 3.74E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF53901 5325 5701 9.26E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.50.720 6759 6960 1.8E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 2531 2636 3.92E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 2351 2472 3.92E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF55048 4232 4293 1.83E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF53901 3572 3948 8.99E-105 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 4952 5160 5.97E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF47336 5233 5344 4.84E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF55048 5985 6046 4.58E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.50.720 1440 1637 2.7E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.50.720 4952 5137 1.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.50.720 3200 3385 9.0E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF55048 2477 2538 6.02E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 6757 6955 7.22E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 756 870 2.25E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 576 697 2.25E-76 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00012 Phosphopantetheine attachment site. 5265 5280 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF47336 3480 3591 2.75E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF08659 KR domain 1441 1619 8.0E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF08659 KR domain 6758 6937 2.5E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF08659 KR domain 4953 5132 1.8E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF08659 KR domain 3201 3380 1.1E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 5859 5980 2.51E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 6039 6147 2.51E-75 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 579 871 2.5E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 4109 4402 7.1E-126 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2354 2646 1.5E-128 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 5862 6154 7.8E-123 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00698 Acyl transferase domain 5861 6173 1.1E-56 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00698 Acyl transferase domain 578 890 1.2E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00698 Acyl transferase domain 4108 4421 4.1E-52 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00698 Acyl transferase domain 2353 2665 1.7E-58 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 5492 5508 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 543 9.0E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 3954 4072 1.2E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2198 2318 4.7E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 5707 5826 4.0E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 38 298 1.3E-89 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.47.10 1821 2082 4.6E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF53901 33 408 4.5E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.30.70.250 4232 4292 9.4E-8 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.30.70.250 5985 6045 4.4E-6 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.30.70.250 2477 2537 6.8E-7 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.30.70.250 702 762 1.5E-6 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00012 Phosphopantetheine attachment site. 7071 7086 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 3200 3393 5.54E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1754 1769 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 6515 6743 5.51E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 3739 3755 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 4106 4227 4.19E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF52151 4286 4392 4.19E-77 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF53901 1816 2192 3.32E-106 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 4756 4940 3.58E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 199 215 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00550 Phosphopantetheine attachment site 3487 3553 5.1E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00550 Phosphopantetheine attachment site 7047 7112 8.9E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00550 Phosphopantetheine attachment site 1729 1795 3.4E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Pfam PF00550 Phosphopantetheine attachment site 5240 5306 5.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4953 5133 4.4E-62 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1441 1621 3.0E-61 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3201 3381 8.4E-64 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6758 6938 3.3E-64 T 17-03-2017 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:1.10.1200.10 1725 1801 4.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:1.10.1200.10 7043 7116 6.7E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:1.10.1200.10 5235 5310 2.6E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:1.10.1200.10 3482 3557 2.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00823 Phosphopantetheine attachment site 5238 5310 2.3E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00823 Phosphopantetheine attachment site 7044 7116 7.3E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00823 Phosphopantetheine attachment site 1727 1799 1.6E-34 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00823 Phosphopantetheine attachment site 3485 3557 2.6E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF55048 702 763 3.27E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00825 Beta-ketoacyl synthase 3578 4004 4.9E-234 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00825 Beta-ketoacyl synthase 1821 2248 3.5E-228 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00825 Beta-ketoacyl synthase 38 464 1.7E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SMART SM00825 Beta-ketoacyl synthase 5331 5757 5.1E-233 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 4293 4402 9.0E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 5856 5980 3.1E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 2348 2472 3.2E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 763 876 1.6E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 6046 6159 3.1E-81 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 573 697 1.6E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 4104 4227 9.0E-80 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 Gene3D G3DSA:3.40.366.10 2538 2651 3.2E-82 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 2997 3183 2.17E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3512 3527 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1983 1999 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS22155 99e984e36ce3b008f7e22e3e47f9b2c4 7197 SUPERFAMILY SSF51735 1439 1637 5.89E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 Pfam PF03947 Ribosomal Proteins L2, C-terminal domain 126 251 5.0E-54 T 17-03-2017 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 ProSitePatterns PS00467 Ribosomal protein L2 signature. 219 230 - T 17-03-2017 IPR022671 Ribosomal protein L2, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 Pfam PF00181 Ribosomal Proteins L2, RNA binding domain 42 118 8.6E-33 T 17-03-2017 IPR022666 Ribosomal Proteins L2, RNA binding domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 Gene3D G3DSA:2.40.50.140 1 115 6.1E-52 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 Gene3D G3DSA:4.10.950.10 197 273 3.8E-32 T 17-03-2017 IPR014726 Ribosomal protein L2, domain 3 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 SMART SM01382 125 253 5.7E-87 T 17-03-2017 IPR022669 Ribosomal protein L2, C-terminal GO:0003735|GO:0005840|GO:0006412 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 Hamap MF_01320_B 50S ribosomal protein L2 [rplB]. 1 273 47.547 T 17-03-2017 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 Gene3D G3DSA:2.30.30.30 120 196 6.9E-29 T 17-03-2017 IPR014722 Ribosomal protein L2 domain 2 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 SUPERFAMILY SSF50104 127 271 2.47E-55 T 17-03-2017 IPR008991 Translation protein SH3-like domain SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 TIGRFAM TIGR01171 rplB_bact: ribosomal protein uL2 3 273 2.0E-127 T 17-03-2017 IPR005880 Ribosomal protein L2, bacterial/organellar-type GO:0003723|GO:0003735|GO:0006412|GO:0015934|GO:0016740 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 SUPERFAMILY SSF50249 3 126 1.47E-49 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 PIRSF PIRSF002158 4 275 2.3E-93 T 17-03-2017 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31180 7dbd3338eb2c136ea287a9008642d311 278 SMART SM01383 42 119 5.2E-40 T 17-03-2017 IPR002171 Ribosomal protein L2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS42320 bb7dc264b74ba03ef013d7fb7fa3856f 47 Gene3D G3DSA:3.40.50.720 1 45 1.9E-5 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 Gene3D G3DSA:3.40.50.1100 42 143 7.1E-39 T 17-03-2017 SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 32 50 - T 17-03-2017 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 9 286 3.2E-69 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 TIGRFAM TIGR01136 cysKM: cysteine synthase 9 298 1.3E-111 T 17-03-2017 IPR005856 Cysteine synthase GO:0004124|GO:0006535 KEGG: 00270+2.5.1.47|KEGG: 00920+2.5.1.47|MetaCyc: PWY-6936 SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 SUPERFAMILY SSF53686 5 295 2.75E-87 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 Gene3D G3DSA:3.40.50.1100 1 41 2.3E-67 T 17-03-2017 SHXM_RS23405 9a915c37d95261670f21f2254392d328 316 Gene3D G3DSA:3.40.50.1100 149 301 2.3E-67 T 17-03-2017 SHXM_RS35475 f04260661f0e09e05a34d8c87d560fd7 169 ProSitePatterns PS01117 MarR-type HTH domain signature. 89 123 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS35475 f04260661f0e09e05a34d8c87d560fd7 169 SMART SM00347 48 149 1.2E-20 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS35475 f04260661f0e09e05a34d8c87d560fd7 169 SUPERFAMILY SSF46785 26 159 5.75E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35475 f04260661f0e09e05a34d8c87d560fd7 169 Pfam PF01047 MarR family 62 113 1.6E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS35475 f04260661f0e09e05a34d8c87d560fd7 169 Gene3D G3DSA:1.10.10.10 29 159 2.9E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07940 270d704972289590c5205e62ca7cc222 261 Pfam PF06386 Gas vesicle synthesis protein GvpL/GvpF 8 249 1.4E-62 T 17-03-2017 IPR009430 Gas vesicle protein GvpL/GvpF GO:0031411|GO:0031412 SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 Gene3D G3DSA:3.40.50.980 16 180 5.3E-29 T 17-03-2017 SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 SUPERFAMILY SSF56801 9 568 7.59E-103 T 17-03-2017 SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 Pfam PF00501 AMP-binding enzyme 21 463 3.9E-76 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 Gene3D G3DSA:3.40.50.980 181 336 2.0E-31 T 17-03-2017 SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 ProSitePatterns PS00455 Putative AMP-binding domain signature. 175 186 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 Gene3D G3DSA:2.30.38.10 372 454 3.6E-18 T 17-03-2017 SHXM_RS37875 3bb278d1bb6609b8a79b51b139f9ae95 578 Gene3D G3DSA:3.30.300.30 455 564 1.1E-13 T 17-03-2017 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 Pfam PF00356 Bacterial regulatory proteins, lacI family 10 54 1.4E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 Gene3D G3DSA:1.10.260.40 9 59 1.1E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 Gene3D G3DSA:3.40.50.2300 60 178 7.3E-36 T 17-03-2017 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 SUPERFAMILY SSF47413 7 65 1.47E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 SUPERFAMILY SSF53822 67 335 1.59E-67 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 Pfam PF13377 Periplasmic binding protein-like domain 174 335 1.3E-38 T 17-03-2017 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 SMART SM00354 7 77 3.1E-26 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS49150 d359810a870fadd9c1b1688c6088493a 336 Gene3D G3DSA:3.40.50.2300 179 316 1.7E-47 T 17-03-2017 SHXM_RS34365 68257568805c96b29dac5b9bce647f7e 152 Pfam PF02391 MoaE protein 23 133 4.9E-35 T 17-03-2017 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS34365 68257568805c96b29dac5b9bce647f7e 152 SUPERFAMILY SSF54690 20 151 9.55E-40 T 17-03-2017 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS34365 68257568805c96b29dac5b9bce647f7e 152 Gene3D G3DSA:3.90.1170.40 17 151 1.4E-45 T 17-03-2017 IPR003448 Molybdopterin biosynthesis MoaE GO:0006777 KEGG: 00790+2.8.1.12|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS35075 ea165b4b7f7492ac3ff7180e98c6e517 260 SUPERFAMILY SSF52980 131 251 8.58E-33 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS35075 ea165b4b7f7492ac3ff7180e98c6e517 260 Pfam PF03852 DNA mismatch endonuclease Vsr 131 193 2.2E-17 T 17-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SHXM_RS35075 ea165b4b7f7492ac3ff7180e98c6e517 260 TIGRFAM TIGR00632 vsr: DNA mismatch endonuclease Vsr 131 240 2.6E-31 T 17-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SHXM_RS35075 ea165b4b7f7492ac3ff7180e98c6e517 260 Gene3D G3DSA:3.40.960.10 141 255 1.4E-38 T 17-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 SUPERFAMILY SSF47203 247 396 3.87E-21 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 Gene3D G3DSA:1.10.540.10 6 137 1.5E-17 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 Gene3D G3DSA:1.20.140.10 236 398 2.7E-29 T 17-03-2017 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 135 5.4E-16 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 SUPERFAMILY SSF56645 51 258 2.62E-63 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 141 234 1.2E-20 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 Gene3D G3DSA:2.40.110.10 140 235 8.5E-34 T 17-03-2017 SHXM_RS10680 1b38fc0b788111e017c4cd7c6469621b 400 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 247 392 1.4E-18 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS43095 e7af88acf232243b5227a0b3db034338 227 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 8 218 3.0E-35 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS43095 e7af88acf232243b5227a0b3db034338 227 Gene3D G3DSA:3.20.20.190 3 221 4.1E-63 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS43095 e7af88acf232243b5227a0b3db034338 227 SUPERFAMILY SSF51695 3 221 1.83E-62 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS02860 d7652fade2c19bfcb33079ea922e7179 348 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 208 4.2E-20 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS02860 d7652fade2c19bfcb33079ea922e7179 348 Gene3D G3DSA:3.40.50.720 1 185 3.4E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02860 d7652fade2c19bfcb33079ea922e7179 348 SUPERFAMILY SSF51735 1 329 1.15E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02860 d7652fade2c19bfcb33079ea922e7179 348 Gene3D G3DSA:3.90.25.10 255 310 1.6E-35 T 17-03-2017 SHXM_RS02860 d7652fade2c19bfcb33079ea922e7179 348 Gene3D G3DSA:3.90.25.10 186 222 1.6E-35 T 17-03-2017 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 SUPERFAMILY SSF46785 36 120 3.4E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 Gene3D G3DSA:1.10.10.10 36 120 1.7E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 Pfam PF03466 LysR substrate binding domain 126 319 5.3E-24 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 Gene3D G3DSA:3.40.190.10 204 275 2.5E-12 T 17-03-2017 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 37 96 1.1E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 SUPERFAMILY SSF53850 126 331 3.98E-23 T 17-03-2017 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 Gene3D G3DSA:3.40.190.10 124 203 4.0E-5 T 17-03-2017 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 52 63 3.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 63 73 3.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS41130 14f1fabf2fcae4c1353d24a6c3e0a2b6 343 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 73 84 3.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS06535 cbc998661899d812740398be59887b11 797 Pfam PF13191 AAA ATPase domain 13 192 3.0E-8 T 17-03-2017 SHXM_RS06535 cbc998661899d812740398be59887b11 797 Gene3D G3DSA:1.25.40.10 614 782 3.8E-42 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SUPERFAMILY SSF52540 13 97 2.48E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06535 cbc998661899d812740398be59887b11 797 SUPERFAMILY SSF52540 209 311 2.48E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06535 cbc998661899d812740398be59887b11 797 SUPERFAMILY SSF48452 523 622 1.64E-17 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SUPERFAMILY SSF48452 599 774 3.13E-40 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 Pfam PF13432 Tetratricopeptide repeat 647 702 1.9E-5 T 17-03-2017 SHXM_RS06535 cbc998661899d812740398be59887b11 797 Pfam PF13432 Tetratricopeptide repeat 546 591 1.4E-7 T 17-03-2017 SHXM_RS06535 cbc998661899d812740398be59887b11 797 Pfam PF13432 Tetratricopeptide repeat 710 771 2.3E-7 T 17-03-2017 SHXM_RS06535 cbc998661899d812740398be59887b11 797 Gene3D G3DSA:1.25.40.10 530 613 6.2E-19 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 704 737 8.8E-5 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 602 635 33.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 568 601 50.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 636 669 0.09 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 738 771 0.0013 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 670 703 22.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS06535 cbc998661899d812740398be59887b11 797 SMART SM00028 534 567 0.0063 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 Gene3D G3DSA:3.90.180.10 1 143 7.8E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 Pfam PF13602 Zinc-binding dehydrogenase 193 300 1.6E-16 T 17-03-2017 SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 SMART SM00829 10 300 2.0E-21 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 89 3.5E-10 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 SUPERFAMILY SSF50129 1 143 8.52E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 SUPERFAMILY SSF51735 112 299 1.02E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04610 f1b5c065fb12185031a2de6b67421b76 302 Gene3D G3DSA:3.40.50.720 144 221 5.1E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 240 351 4.5E-30 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 Gene3D G3DSA:3.40.47.10 7 243 6.4E-29 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 SUPERFAMILY SSF53901 3 237 1.18E-32 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 Gene3D G3DSA:3.40.47.10 249 393 1.8E-52 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 SUPERFAMILY SSF53901 198 393 6.29E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 SMART SM00825 Beta-ketoacyl synthase 5 394 2.1E-11 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46565 d072d7da1b990ee9d317472456941c6d 394 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 58 228 9.3E-19 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS41755 8d42896ae489f1b2cd6773e64dcba2b7 118 Gene3D G3DSA:1.10.357.10 19 95 1.4E-5 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41755 8d42896ae489f1b2cd6773e64dcba2b7 118 SUPERFAMILY SSF48498 4 99 1.18E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS24055 90d5407d3b2f2a496e12c7181e3c5ae5 188 Pfam PF01965 DJ-1/PfpI family 4 179 9.6E-50 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS24055 90d5407d3b2f2a496e12c7181e3c5ae5 188 SUPERFAMILY SSF52317 1 182 1.51E-51 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS24055 90d5407d3b2f2a496e12c7181e3c5ae5 188 TIGRFAM TIGR01382 PfpI: intracellular protease, PfpI family 4 181 4.4E-51 T 17-03-2017 IPR006286 Peptidase C56, PfpI SHXM_RS24055 90d5407d3b2f2a496e12c7181e3c5ae5 188 Gene3D G3DSA:3.40.50.880 1 183 7.7E-55 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 20 211 39.174 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 Gene3D G3DSA:3.90.226.10 21 211 4.1E-73 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 Pfam PF00574 Clp protease 30 210 1.7E-75 T 17-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 PRINTS PR00127 Clp protease catalytic subunit P signature 36 51 1.1E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 PRINTS PR00127 Clp protease catalytic subunit P signature 186 205 1.1E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 PRINTS PR00127 Clp protease catalytic subunit P signature 128 147 1.1E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 PRINTS PR00127 Clp protease catalytic subunit P signature 76 96 1.1E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 PRINTS PR00127 Clp protease catalytic subunit P signature 107 124 1.1E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 ProSitePatterns PS00382 Endopeptidase Clp histidine active site. 129 142 - T 17-03-2017 IPR033135 ClpP, histidine active site SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 ProSitePatterns PS00381 Endopeptidase Clp serine active site. 107 118 - T 17-03-2017 IPR018215 ClpP, Ser active site SHXM_RS21700 13a6a862d444c8176d3896bc5d007c8f 218 SUPERFAMILY SSF52096 28 212 2.98E-61 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS41215 55370f87ade47d342b9e5a5586f4c043 152 SUPERFAMILY SSF54427 5 150 5.66E-18 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS41215 55370f87ade47d342b9e5a5586f4c043 152 Gene3D G3DSA:3.10.450.50 10 143 2.5E-13 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS41215 55370f87ade47d342b9e5a5586f4c043 152 Pfam PF13577 SnoaL-like domain 7 135 9.7E-10 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS13815 5111013301611046bc0f4664633cb966 204 Gene3D G3DSA:1.10.340.30 4 183 2.1E-75 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS13815 5111013301611046bc0f4664633cb966 204 SUPERFAMILY SSF48150 4 184 2.16E-73 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS13815 5111013301611046bc0f4664633cb966 204 Pfam PF03352 Methyladenine glycosylase 8 182 2.0E-73 T 17-03-2017 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 SHXM_RS50285 8aa0647832f31f43406de84376ada088 174 Gene3D G3DSA:3.40.190.10 12 55 1.0E-6 T 17-03-2017 SHXM_RS50285 8aa0647832f31f43406de84376ada088 174 SUPERFAMILY SSF53850 10 168 4.34E-13 T 17-03-2017 SHXM_RS50285 8aa0647832f31f43406de84376ada088 174 Pfam PF03466 LysR substrate binding domain 9 168 3.0E-13 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS50285 8aa0647832f31f43406de84376ada088 174 Gene3D G3DSA:3.40.190.10 56 144 2.4E-8 T 17-03-2017 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 152 167 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 271 282 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 318 333 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 135 151 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 88 99 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 190 212 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 339 348 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 348 359 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00359 B-class P450 signature 290 317 5.9E-59 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 Pfam PF00067 Cytochrome P450 185 369 2.9E-21 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 Pfam PF00067 Cytochrome P450 22 129 1.8E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00385 P450 superfamily signature 348 359 1.4E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00385 P450 superfamily signature 339 348 1.4E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00385 P450 superfamily signature 236 253 1.4E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 PRINTS PR00385 P450 superfamily signature 271 282 1.4E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 Gene3D G3DSA:1.10.630.10 10 396 1.2E-123 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 341 350 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS04105 fb238fede19a4493a4266829179d7fcb 396 SUPERFAMILY SSF48264 21 396 1.01E-95 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 Pfam PF01270 Glycosyl hydrolases family 8 39 267 7.9E-17 T 17-03-2017 IPR002037 Glycoside hydrolase, family 8 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 Gene3D G3DSA:1.50.10.10 17 401 4.6E-89 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 PRINTS PR00735 Glycosyl hydrolase family 8 signature 71 84 3.4E-17 T 17-03-2017 IPR002037 Glycoside hydrolase, family 8 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 PRINTS PR00735 Glycosyl hydrolase family 8 signature 133 151 3.4E-17 T 17-03-2017 IPR002037 Glycoside hydrolase, family 8 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 PRINTS PR00735 Glycosyl hydrolase family 8 signature 270 279 3.4E-17 T 17-03-2017 IPR002037 Glycoside hydrolase, family 8 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 PRINTS PR00735 Glycosyl hydrolase family 8 signature 239 250 3.4E-17 T 17-03-2017 IPR002037 Glycoside hydrolase, family 8 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 PRINTS PR00735 Glycosyl hydrolase family 8 signature 196 213 3.4E-17 T 17-03-2017 IPR002037 Glycoside hydrolase, family 8 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS26660 29357b875006394ef2a2f9f6c1d684f0 401 SUPERFAMILY SSF48208 64 400 1.42E-71 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS03130 fb74f248345021e34cdfd880b281c047 273 Gene3D G3DSA:3.30.1050.10 185 252 2.1E-4 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS03130 fb74f248345021e34cdfd880b281c047 273 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 22 152 6.8E-7 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS03130 fb74f248345021e34cdfd880b281c047 273 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 21 241 5.3E-21 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS03130 fb74f248345021e34cdfd880b281c047 273 SUPERFAMILY SSF109854 17 159 1.59E-12 T 17-03-2017 SHXM_RS03130 fb74f248345021e34cdfd880b281c047 273 SUPERFAMILY SSF55718 175 258 4.24E-8 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 ProSitePatterns PS00885 EPSP synthase signature 2. 363 381 - T 17-03-2017 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 Gene3D G3DSA:3.65.10.10 34 262 1.4E-63 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 PIRSF PIRSF000505 13 453 4.8E-110 T 17-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 Hamap MF_00210 3-phosphoshikimate 1-carboxyvinyltransferase [aroA]. 22 450 28.627 T 17-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 Gene3D G3DSA:3.65.10.10 263 445 1.1E-51 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 ProSitePatterns PS00104 EPSP synthase signature 1. 110 124 - T 17-03-2017 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 SUPERFAMILY SSF55205 22 447 6.41E-100 T 17-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 TIGRFAM TIGR01356 aroA: 3-phosphoshikimate 1-carboxyvinyltransferase 27 447 1.2E-109 T 17-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS34440 f6326f2b0e0c94e5295428f0e3c4c722 458 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 21 441 5.3E-103 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS44170 9ee758173b3b4a3d04fe509784eed498 394 Pfam PF00155 Aminotransferase class I and II 34 385 5.7E-61 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS44170 9ee758173b3b4a3d04fe509784eed498 394 Gene3D G3DSA:3.40.640.10 47 275 3.4E-70 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS44170 9ee758173b3b4a3d04fe509784eed498 394 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 236 249 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS44170 9ee758173b3b4a3d04fe509784eed498 394 Gene3D G3DSA:3.90.1150.10 276 392 2.4E-28 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS44170 9ee758173b3b4a3d04fe509784eed498 394 SUPERFAMILY SSF53383 6 391 1.28E-105 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 SUPERFAMILY SSF110921 404 518 1.57E-21 T 17-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 TIGRFAM TIGR00977 citramal_synth: citramalate synthase 10 525 2.2E-192 T 17-03-2017 IPR005675 Citramalate synthase GO:0019752|GO:0046912 KEGG: 00290+2.3.1.182|KEGG: 00660+2.3.1.182|MetaCyc: PWY-5101 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 Pfam PF00682 HMGL-like 11 278 5.2E-46 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 Pfam PF08502 LeuA allosteric (dimerisation) domain 380 520 8.4E-26 T 17-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 SUPERFAMILY SSF51569 6 297 4.4E-75 T 17-03-2017 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 16 32 - T 17-03-2017 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 SMART SM00917 380 523 7.7E-38 T 17-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS36245 353a6a56d5cb16db40bc7f6affee78fb 532 Gene3D G3DSA:3.20.20.70 8 354 1.2E-112 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 ProSitePatterns PS00622 LuxR-type HTH domain signature. 187 214 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 SUPERFAMILY SSF46894 162 234 1.46E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 Gene3D G3DSA:3.40.50.2300 21 178 7.9E-40 T 17-03-2017 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 203 215 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 203 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 187 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 SUPERFAMILY SSF52172 22 146 6.69E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 SMART SM00421 170 227 9.5E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 Pfam PF00196 Bacterial regulatory proteins, luxR family 173 227 3.0E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 Pfam PF00072 Response regulator receiver domain 25 136 1.5E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 Gene3D G3DSA:1.10.10.10 179 233 1.1E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39465 291c1a453255e25202511d5bfa20207d 235 SMART SM00448 23 136 3.6E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS23665 9e5023e78ce7efbc9867242dfbc85705 331 Gene3D G3DSA:1.10.3720.10 34 321 7.0E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23665 9e5023e78ce7efbc9867242dfbc85705 331 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 125 324 4.7E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23665 9e5023e78ce7efbc9867242dfbc85705 331 SUPERFAMILY SSF161098 87 319 2.09E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 Gene3D G3DSA:2.40.30.60 3 90 4.6E-21 T 17-03-2017 IPR002676 RimM protein GO:0006364 SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 SUPERFAMILY SSF50447 3 85 6.36E-18 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 Gene3D G3DSA:2.30.30.240 96 166 3.4E-19 T 17-03-2017 SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 TIGRFAM TIGR02273 16S_RimM: 16S rRNA processing protein RimM 3 166 5.7E-42 T 17-03-2017 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 Hamap MF_00014 Ribosome maturation factor RimM [rimM]. 2 166 23.018 T 17-03-2017 IPR011961 16S rRNA processing protein RimM GO:0005840|GO:0006364|GO:0043022 SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 SUPERFAMILY SSF50346 96 166 1.2E-17 T 17-03-2017 IPR011033 PRC-barrel-like SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 Pfam PF05239 PRC-barrel domain 94 166 7.8E-9 T 17-03-2017 IPR027275 PRC-barrel domain SHXM_RS36580 a56f1db360fcc63dc20c1de0d321138a 215 Pfam PF01782 RimM N-terminal domain 5 83 3.6E-22 T 17-03-2017 IPR002676 RimM protein GO:0006364 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 Pfam PF13432 Tetratricopeptide repeat 167 228 0.003 T 17-03-2017 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 SUPERFAMILY SSF47413 4 69 1.32E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 Pfam PF13560 Helix-turn-helix domain 5 61 8.3E-14 T 17-03-2017 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 SUPERFAMILY SSF48452 162 276 1.56E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 SMART SM00530 9 65 6.7E-12 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 Gene3D G3DSA:1.10.260.40 4 66 5.7E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41570 ffb66944c6afea377111077419c095c9 404 Gene3D G3DSA:1.25.40.10 154 278 5.1E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 Gene3D G3DSA:3.20.20.70 3 219 8.1E-92 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 PIRSF PIRSF001461 1 222 3.0E-96 T 17-03-2017 IPR026019 Ribulose-phosphate 3-epimerase GO:0004750|GO:0006098 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 TIGRFAM TIGR01163 rpe: ribulose-phosphate 3-epimerase 5 212 2.2E-82 T 17-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 SUPERFAMILY SSF51366 4 214 1.0E-63 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 Pfam PF00834 Ribulose-phosphate 3 epimerase family 5 199 7.6E-79 T 17-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 ProSitePatterns PS01085 Ribulose-phosphate 3-epimerase family signature 1. 30 44 - T 17-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS12280 d6c66d83a060fe34a3824e0e154939af 224 ProSitePatterns PS01086 Ribulose-phosphate 3-epimerase family signature 2. 132 154 - T 17-03-2017 IPR000056 Ribulose-phosphate 3-epimerase-like GO:0005975|GO:0016857 KEGG: 00030+5.1.3.1|KEGG: 00040+5.1.3.1|KEGG: 00710+5.1.3.1|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS08880 9f93cf466d7c7a7d8f393cca61c990c1 238 Pfam PF01526 Tn3 transposase DDE domain 1 210 1.3E-62 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS38685 a67a4d1eb9f49ab3f0029147d0681937 202 SUPERFAMILY SSF46689 8 83 1.49E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38685 a67a4d1eb9f49ab3f0029147d0681937 202 SUPERFAMILY SSF48498 85 200 1.78E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS38685 a67a4d1eb9f49ab3f0029147d0681937 202 ProSitePatterns PS01081 TetR-type HTH domain signature. 32 62 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS38685 a67a4d1eb9f49ab3f0029147d0681937 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 65 6.8E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38685 a67a4d1eb9f49ab3f0029147d0681937 202 Gene3D G3DSA:1.10.357.10 75 200 3.8E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS38685 a67a4d1eb9f49ab3f0029147d0681937 202 Gene3D G3DSA:1.10.10.60 9 72 7.3E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02420 1ad7aac1cb18cf47d9f9f38f20ffbcca 400 SUPERFAMILY SSF159501 16 397 1.26E-86 T 17-03-2017 SHXM_RS02420 1ad7aac1cb18cf47d9f9f38f20ffbcca 400 Pfam PF05139 Erythromycin esterase 52 397 1.4E-70 T 17-03-2017 IPR007815 Erythromycin esterase GO:0046677 SHXM_RS02420 1ad7aac1cb18cf47d9f9f38f20ffbcca 400 Gene3D G3DSA:3.30.1870.10 55 127 5.2E-18 T 17-03-2017 SHXM_RS02420 1ad7aac1cb18cf47d9f9f38f20ffbcca 400 Gene3D G3DSA:3.40.1660.10 26 53 1.8E-13 T 17-03-2017 SHXM_RS02420 1ad7aac1cb18cf47d9f9f38f20ffbcca 400 Gene3D G3DSA:3.40.1660.10 278 366 1.8E-13 T 17-03-2017 SHXM_RS02420 1ad7aac1cb18cf47d9f9f38f20ffbcca 400 PIRSF PIRSF036794 1 400 3.3E-100 T 17-03-2017 IPR014622 Uncharacterised conserved protein UCP036794, erythromycin esterase-type SHXM_RS28205 c0445782723c296316912a609162392e 177 SUPERFAMILY SSF50891 6 171 4.38E-58 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS28205 c0445782723c296316912a609162392e 177 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 7 171 2.1E-42 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 PIRSF PIRSF001467 2 176 2.4E-53 T 17-03-2017 IPR024936 Cyclophilin-type peptidyl-prolyl cis-trans isomerase GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 Gene3D G3DSA:2.40.100.10 4 172 2.8E-59 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS28205 c0445782723c296316912a609162392e 177 ProSitePatterns PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 56 73 - T 17-03-2017 IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 61 73 3.3E-27 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 116 128 3.3E-27 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 129 144 3.3E-27 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 20 35 3.3E-27 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS28205 c0445782723c296316912a609162392e 177 PRINTS PR00153 Cyclophilin peptidyl-prolyl cis-trans isomerase signature 101 116 3.3E-27 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS49105 5ed478d77bb79465d0eed0cc2169e561 394 SUPERFAMILY SSF53098 57 368 5.23E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS49105 5ed478d77bb79465d0eed0cc2169e561 394 Pfam PF13546 DDE superfamily endonuclease 22 236 2.3E-53 T 17-03-2017 SHXM_RS15600 f28d418c6264c260812903354a0bbaea 306 Gene3D G3DSA:3.20.20.150 2 292 1.3E-56 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS15600 f28d418c6264c260812903354a0bbaea 306 Pfam PF01261 Xylose isomerase-like TIM barrel 20 209 4.5E-29 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS15600 f28d418c6264c260812903354a0bbaea 306 SUPERFAMILY SSF51658 2 292 5.37E-53 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS15600 f28d418c6264c260812903354a0bbaea 306 Pfam PF07582 AP endonuclease family 2 C terminus 242 287 1.1E-5 T 17-03-2017 IPR011418 AP endonuclease, family 2, C-terminal SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 TIGRFAM TIGR01129 secD: protein-export membrane protein SecD 45 540 1.3E-106 T 17-03-2017 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 Hamap MF_01463_B Protein translocase subunit SecD [secD]. 9 554 38.764 T 17-03-2017 IPR005791 Protein translocase subunit SecD GO:0006886|GO:0015450 SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 Pfam PF02355 Protein export membrane protein 369 544 4.5E-11 T 17-03-2017 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 SUPERFAMILY SSF82866 346 546 3.66E-37 T 17-03-2017 SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 294 532 2.5E-62 T 17-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 Gene3D G3DSA:1.20.1640.10 348 547 1.5E-21 T 17-03-2017 SHXM_RS12530 32bcb5941b4bd72abadbc8a6b2dbc5bb 585 Pfam PF07549 SecD/SecF GG Motif 42 61 4.5E-4 T 17-03-2017 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site SHXM_RS43715 ee8981d84b0ae6b3d6f69c3537e22448 322 Pfam PF06166 Protein of unknown function (DUF979) 5 322 8.5E-118 T 17-03-2017 IPR009323 Protein of unknown function DUF979 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 Gene3D G3DSA:3.50.50.60 6 112 8.6E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 Gene3D G3DSA:3.50.50.60 270 345 8.6E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 Gene3D G3DSA:3.50.50.60 113 269 9.7E-20 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 9 28 2.6E-7 T 17-03-2017 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 166 184 2.6E-7 T 17-03-2017 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 106 124 2.6E-7 T 17-03-2017 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 8 333 3.6E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 SUPERFAMILY SSF51905 142 351 2.19E-12 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 SUPERFAMILY SSF51905 5 175 2.16E-26 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24530 5e2a45bc24f86a7a433c8dc033bc000c 459 SUPERFAMILY SSF51905 263 343 2.16E-26 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 SUPERFAMILY SSF48498 86 205 7.23E-8 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 SUPERFAMILY SSF46689 11 91 6.48E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 3.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 3.5E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 63 6.1E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 Gene3D G3DSA:1.10.10.60 12 60 2.9E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10645 6236b2be52d071fe1423730658854c6b 207 Gene3D G3DSA:1.10.357.10 61 206 5.6E-21 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 4 172 7.6E-52 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 Gene3D G3DSA:3.40.50.1220 184 335 4.3E-50 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 SUPERFAMILY SSF52467 157 361 3.85E-48 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 Gene3D G3DSA:3.40.50.970 2 182 7.8E-60 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 SUPERFAMILY SSF52518 1 184 3.1E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 SUPERFAMILY SSF52518 369 570 1.73E-51 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 193 327 6.1E-36 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 TIGRFAM TIGR01504 glyox_carbo_lig: glyoxylate carboligase 2 588 0.0 T 17-03-2017 IPR006397 Glyoxylate carboligase GO:0009028|GO:0009436 KEGG: 00630+4.1.1.47 SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 Gene3D G3DSA:3.40.50.970 362 576 1.3E-59 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40900 935c30b899a682a3d308f831deb97753 592 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 393 553 1.3E-34 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS06180 325d4bdb5119dae1ad39dc426619226c 363 Pfam PF08279 HTH domain 8 63 1.9E-16 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS06180 325d4bdb5119dae1ad39dc426619226c 363 SUPERFAMILY SSF46785 4 66 1.8E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06180 325d4bdb5119dae1ad39dc426619226c 363 Gene3D G3DSA:1.10.10.10 4 66 2.9E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06180 325d4bdb5119dae1ad39dc426619226c 363 Pfam PF13280 WYL domain 142 318 3.3E-37 T 17-03-2017 IPR026881 WYL domain SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 TIGRFAM TIGR01454 AHBA_synth_RP: AHBA synthesis associated protein 18 221 1.6E-107 T 17-03-2017 IPR006351 3-amino-5-hydroxybenzoic acid synthesis-related SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 Pfam PF13419 Haloacid dehalogenase-like hydrolase 18 190 2.4E-32 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 15 26 2.2E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 104 117 2.2E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 135 151 2.2E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 153 173 2.2E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 Gene3D G3DSA:3.40.50.1000 95 220 5.1E-40 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 Gene3D G3DSA:3.40.50.1000 12 29 5.1E-40 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 126 189 3.6E-8 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 SUPERFAMILY SSF56784 14 220 3.66E-53 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05065 c765916264b09e6cae2fc042b15510dd 226 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 97 185 1.7E-8 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS32560 f8d016d7bda915ad5918e4934a4d44fc 373 ProDom PD486863 PRECURSOR CBIM SIGNAL COBALT MEMBRANE VITAMIN B12 BIOSYNTHESIS COBALAMIN ABC-TYPE 290 363 5.0E-25 T 17-03-2017 SHXM_RS32560 f8d016d7bda915ad5918e4934a4d44fc 373 Pfam PF01891 Cobalt uptake substrate-specific transmembrane region 2 208 1.9E-60 T 17-03-2017 IPR002751 Cobalamin (vitamin B12) biosynthesis CbiM family GO:0000041|GO:0016021 SHXM_RS32560 f8d016d7bda915ad5918e4934a4d44fc 373 Pfam PF13190 PDGLE domain 282 358 2.3E-17 T 17-03-2017 IPR025937 PDGLE domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Pfam PF08448 PAS fold 138 246 3.3E-15 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SUPERFAMILY SSF55785 130 243 1.05E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SMART SM00091 130 196 1.2 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SMART SM00091 10 78 0.02 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SUPERFAMILY SSF55785 23 105 2.93E-12 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Pfam PF13426 PAS domain 28 102 7.5E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SMART SM00331 460 679 7.0E-30 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Pfam PF13581 Histidine kinase-like ATPase domain 692 798 1.4E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Gene3D G3DSA:3.30.450.20 131 245 1.1E-15 T 17-03-2017 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Gene3D G3DSA:3.30.450.40 257 437 9.3E-36 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Gene3D G3DSA:3.30.450.20 25 104 1.1E-10 T 17-03-2017 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SUPERFAMILY SSF55874 720 800 2.26E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SUPERFAMILY SSF55781 339 433 2.4E-14 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SMART SM00065 250 439 2.0E-7 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 135 252 3.3E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 22 102 8.5E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 SUPERFAMILY SSF81606 472 678 7.85E-7 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Pfam PF01590 GAF domain 319 429 3.6E-10 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS34720 71dc9e9f18aeb7b07c290ce212dfc399 817 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 487 679 3.4E-48 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50670 02c0e13aedd60c5e7e8c07b93da6f657 297 Pfam PF13649 Methyltransferase domain 64 161 4.2E-18 T 17-03-2017 SHXM_RS50670 02c0e13aedd60c5e7e8c07b93da6f657 297 SUPERFAMILY SSF53335 43 230 1.3E-35 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS50670 02c0e13aedd60c5e7e8c07b93da6f657 297 Gene3D G3DSA:3.40.50.150 45 240 3.9E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11550 10f7993b29cbbeb97104252616b70e61 594 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 233 257 2.6E-8 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS11550 10f7993b29cbbeb97104252616b70e61 594 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 325 344 2.6E-8 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS11550 10f7993b29cbbeb97104252616b70e61 594 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 161 185 2.6E-8 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS11550 10f7993b29cbbeb97104252616b70e61 594 Pfam PF00361 Proton-conducting membrane transporter 125 401 6.7E-59 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS49590 bd8ae2a8bf46de2f66ace996a4798989 429 SUPERFAMILY SSF53474 114 317 2.67E-16 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49590 bd8ae2a8bf46de2f66ace996a4798989 429 Gene3D G3DSA:3.40.50.1820 116 249 1.8E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49590 bd8ae2a8bf46de2f66ace996a4798989 429 Gene3D G3DSA:3.40.50.1820 352 428 1.8E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07475 43fe0de1a235ef8aec917f935c1295dc 304 Gene3D G3DSA:3.60.15.10 1 304 1.5E-80 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS07475 43fe0de1a235ef8aec917f935c1295dc 304 SUPERFAMILY SSF56281 1 304 2.8E-36 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS07475 43fe0de1a235ef8aec917f935c1295dc 304 Pfam PF12706 Beta-lactamase superfamily domain 48 269 3.5E-26 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS07475 43fe0de1a235ef8aec917f935c1295dc 304 Hamap MF_00653 Coenzyme PQQ synthesis protein B [pqqB]. 1 304 101.17 T 17-03-2017 IPR011842 Coenzyme PQQ biosynthesis protein B GO:0006810|GO:0018189 SHXM_RS24585 80bb10b9077d13a58cd3f6419c27792d 196 Pfam PF03029 Conserved hypothetical ATP binding protein 25 191 3.6E-22 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS24585 80bb10b9077d13a58cd3f6419c27792d 196 Gene3D G3DSA:3.40.50.300 20 194 1.8E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24585 80bb10b9077d13a58cd3f6419c27792d 196 SUPERFAMILY SSF52540 21 194 1.32E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 4 247 6.7E-51 T 17-03-2017 SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 Gene3D G3DSA:3.40.50.720 1 249 7.6E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 SUPERFAMILY SSF51735 2 250 2.58E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 70 81 2.9E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 2.9E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 2.9E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 146 174 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1 192 1.5E-4 T 17-03-2017 SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 70 81 6.1E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 6.1E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 6.1E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 6.1E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 6.1E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10705 0814d66b485b8886bfe1a4deaed3bfd1 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 23 40 6.1E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05285 68305bc2acaf0b9e37593a9194e697fa 117 Gene3D G3DSA:1.10.1200.10 2 64 2.0E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05285 68305bc2acaf0b9e37593a9194e697fa 117 SUPERFAMILY SSF47336 2 72 1.44E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05285 68305bc2acaf0b9e37593a9194e697fa 117 Pfam PF00550 Phosphopantetheine attachment site 2 60 3.2E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05285 68305bc2acaf0b9e37593a9194e697fa 117 SMART SM01294 7 60 5.0E-5 T 17-03-2017 SHXM_RS05285 68305bc2acaf0b9e37593a9194e697fa 117 ProSitePatterns PS00012 Phosphopantetheine attachment site. 19 34 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05285 68305bc2acaf0b9e37593a9194e697fa 117 SMART SM00823 Phosphopantetheine attachment site 2 64 4.2E-19 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS10255 4d0b654c5e38ed7dfe1f1d5ff16d786d 199 Gene3D G3DSA:3.40.50.300 9 184 1.5E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10255 4d0b654c5e38ed7dfe1f1d5ff16d786d 199 SUPERFAMILY SSF52540 6 151 6.12E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10255 4d0b654c5e38ed7dfe1f1d5ff16d786d 199 Pfam PF13521 AAA domain 9 180 2.1E-13 T 17-03-2017 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 PIRSF PIRSF000726 59 418 1.5E-125 T 17-03-2017 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 SUPERFAMILY SSF53633 4 243 8.77E-74 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 SUPERFAMILY SSF55021 338 412 6.21E-21 T 17-03-2017 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 TIGRFAM TIGR00656 asp_kin_monofn: aspartate kinase, monofunctional class 2 410 6.7E-125 T 17-03-2017 IPR005260 Aspartate kinase, monofunctional class GO:0004072|GO:0009089 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 Pfam PF01842 ACT domain 272 335 5.2E-9 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 ProSitePatterns PS00324 Aspartokinase signature. 5 13 - T 17-03-2017 IPR018042 Aspartate kinase, conserved site GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 Pfam PF13840 ACT domain 345 406 7.6E-12 T 17-03-2017 IPR027795 GATS-like ACT domain SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 Gene3D G3DSA:3.40.1160.10 3 245 9.2E-73 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 Pfam PF00696 Amino acid kinase family 3 231 3.7E-54 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 SUPERFAMILY SSF55021 254 335 4.85E-19 T 17-03-2017 SHXM_RS27135 97698c7ebb2366b9918468bf9ca27a34 426 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 64 410 2.0E-116 T 17-03-2017 IPR001341 Aspartate kinase domain GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 Gene3D G3DSA:3.40.50.2300 2 122 2.0E-40 T 17-03-2017 SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 Gene3D G3DSA:1.10.10.10 123 222 1.1E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 SMART SM00862 145 220 1.2E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 SUPERFAMILY SSF52172 2 175 2.78E-41 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 Pfam PF00072 Response regulator receiver domain 3 112 1.7E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 220 7.8E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS45910 35e9b121ee6f6bc5294e7f7c9a2183b8 225 SMART SM00448 1 112 9.9E-41 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS49645 3ef1edf3cb35e7a195d3c238cb8d05fd 985 Gene3D G3DSA:3.40.640.10 612 861 2.5E-60 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS49645 3ef1edf3cb35e7a195d3c238cb8d05fd 985 SUPERFAMILY SSF53383 570 981 6.87E-98 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS49645 3ef1edf3cb35e7a195d3c238cb8d05fd 985 SUPERFAMILY SSF56112 20 337 6.63E-34 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS49645 3ef1edf3cb35e7a195d3c238cb8d05fd 985 Gene3D G3DSA:3.90.1200.10 136 323 6.8E-18 T 17-03-2017 SHXM_RS49645 3ef1edf3cb35e7a195d3c238cb8d05fd 985 Gene3D G3DSA:3.90.1150.10 862 981 1.7E-31 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS49645 3ef1edf3cb35e7a195d3c238cb8d05fd 985 Pfam PF00202 Aminotransferase class-III 581 978 1.1E-68 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS50165 33399df1957c71e95ac39f122795e76a 175 Pfam PF13358 DDE superfamily endonuclease 9 137 5.2E-19 T 17-03-2017 SHXM_RS49095 33399df1957c71e95ac39f122795e76a 175 Pfam PF13358 DDE superfamily endonuclease 9 137 5.2E-19 T 17-03-2017 SHXM_RS00400 33399df1957c71e95ac39f122795e76a 175 Pfam PF13358 DDE superfamily endonuclease 9 137 5.2E-19 T 17-03-2017 SHXM_RS48210 33399df1957c71e95ac39f122795e76a 175 Pfam PF13358 DDE superfamily endonuclease 9 137 5.2E-19 T 17-03-2017 SHXM_RS34480 9dfd2d57d8005e77a13a27c276489f5d 433 SUPERFAMILY SSF109604 256 423 3.62E-11 T 17-03-2017 SHXM_RS34480 9dfd2d57d8005e77a13a27c276489f5d 433 SMART SM00471 270 392 5.2E-4 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS34480 9dfd2d57d8005e77a13a27c276489f5d 433 Pfam PF01966 HD domain 277 375 8.0E-5 T 17-03-2017 IPR006674 HD domain SHXM_RS34480 9dfd2d57d8005e77a13a27c276489f5d 433 Gene3D G3DSA:1.10.3150.10 274 416 1.2E-9 T 17-03-2017 IPR013976 Metal-dependent hydrolase HDOD SHXM_RS29715 d162372ef72c6800461eff74ab931556 314 SUPERFAMILY SSF51430 10 312 4.19E-80 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS29715 d162372ef72c6800461eff74ab931556 314 Gene3D G3DSA:3.20.20.100 10 312 6.3E-81 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS29715 d162372ef72c6800461eff74ab931556 314 Pfam PF00248 Aldo/keto reductase family 18 312 1.4E-66 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS29715 d162372ef72c6800461eff74ab931556 314 PRINTS PR00069 Aldo-keto reductase signature 140 157 9.6E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS29715 d162372ef72c6800461eff74ab931556 314 PRINTS PR00069 Aldo-keto reductase signature 109 127 9.6E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 Pfam PF13377 Periplasmic binding protein-like domain 173 322 3.3E-18 T 17-03-2017 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 Gene3D G3DSA:1.10.260.40 7 57 4.6E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 ProSitePatterns PS00356 LacI-type HTH domain signature. 7 25 - T 17-03-2017 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 SUPERFAMILY SSF53822 65 322 1.61E-42 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 SMART SM00354 4 75 4.1E-20 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 52 1.4E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 Gene3D G3DSA:3.40.50.2300 179 303 2.9E-28 T 17-03-2017 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 Gene3D G3DSA:3.40.50.2300 58 178 2.3E-27 T 17-03-2017 SHXM_RS47770 7679252906837c5ec60a7c70df34b692 323 SUPERFAMILY SSF47413 4 63 7.39E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12690 ab1edbadb7b7b1c9009db4fe28dd08ed 171 SUPERFAMILY SSF52833 5 160 3.05E-27 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS12690 ab1edbadb7b7b1c9009db4fe28dd08ed 171 Pfam PF01323 DSBA-like thioredoxin domain 12 159 1.2E-22 T 17-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 SHXM_RS12690 ab1edbadb7b7b1c9009db4fe28dd08ed 171 Gene3D G3DSA:3.40.30.10 4 164 7.8E-31 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 Gene3D G3DSA:3.40.50.300 509 709 1.2E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 SUPERFAMILY SSF52540 509 694 4.85E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 ProSitePatterns PS01331 Thymidylate kinase signature. 599 611 - T 17-03-2017 IPR018095 Thymidylate kinase, conserved site GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 SUPERFAMILY SSF103473 207 476 4.97E-9 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 Hamap MF_00165 Thymidylate kinase [tmk]. 510 709 30.782 T 17-03-2017 IPR018094 Thymidylate kinase GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 Gene3D G3DSA:1.20.1250.20 290 469 6.4E-12 T 17-03-2017 SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 TIGRFAM TIGR00041 DTMP_kinase: dTMP kinase 509 697 1.9E-50 T 17-03-2017 IPR018094 Thymidylate kinase GO:0004798|GO:0005524|GO:0006233 KEGG: 00240+2.7.4.9|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7210|Reactome: R-HSA-499943 SHXM_RS26860 d2fde14abcd4e1e8353e1f12be1113d0 1109 Pfam PF02223 Thymidylate kinase 514 698 1.3E-46 T 17-03-2017 SHXM_RS36930 1332e11b600113ff6237d88b338cce10 98 SUPERFAMILY SSF103007 1 93 2.09E-30 T 17-03-2017 IPR007546 Protein of unknown function DUF503 SHXM_RS36930 1332e11b600113ff6237d88b338cce10 98 Gene3D G3DSA:3.30.70.1120 1 96 8.5E-37 T 17-03-2017 IPR007546 Protein of unknown function DUF503 SHXM_RS36930 1332e11b600113ff6237d88b338cce10 98 Pfam PF04456 Protein of unknown function (DUF503) 3 89 4.7E-32 T 17-03-2017 IPR007546 Protein of unknown function DUF503 SHXM_RS01280 79e78f23a51538ce348e1ca23465621e 220 Gene3D G3DSA:3.20.20.70 1 124 7.8E-24 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS01280 79e78f23a51538ce348e1ca23465621e 220 Gene3D G3DSA:2.60.40.1180 125 219 3.2E-23 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS01280 79e78f23a51538ce348e1ca23465621e 220 Pfam PF16499 Alpha galactosidase A 55 194 5.2E-10 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS01280 79e78f23a51538ce348e1ca23465621e 220 SUPERFAMILY SSF51011 139 218 1.44E-11 T 17-03-2017 SHXM_RS01280 79e78f23a51538ce348e1ca23465621e 220 SUPERFAMILY SSF51445 21 129 8.85E-11 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS12960 8219c146ac8c3b2b493c669ba73b0b0b 262 Gene3D G3DSA:1.10.3720.10 6 254 2.1E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12960 8219c146ac8c3b2b493c669ba73b0b0b 262 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 77 247 3.0E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12960 8219c146ac8c3b2b493c669ba73b0b0b 262 SUPERFAMILY SSF161098 4 254 3.27E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06650 336652850ad55e433f58b1909798fb14 269 Pfam PF02274 Amidinotransferase 33 268 4.4E-24 T 17-03-2017 SHXM_RS06650 336652850ad55e433f58b1909798fb14 269 SUPERFAMILY SSF55909 10 269 2.68E-58 T 17-03-2017 SHXM_RS06650 336652850ad55e433f58b1909798fb14 269 Gene3D G3DSA:3.75.10.10 8 268 5.1E-66 T 17-03-2017 SHXM_RS28300 382b2693e6cd8c71ca554179004b9177 117 SUPERFAMILY SSF52821 10 107 1.02E-27 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS28300 382b2693e6cd8c71ca554179004b9177 117 Gene3D G3DSA:3.40.250.10 16 106 7.9E-25 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS28300 382b2693e6cd8c71ca554179004b9177 117 SMART SM00450 4 102 2.6E-18 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS28300 382b2693e6cd8c71ca554179004b9177 117 Pfam PF00581 Rhodanese-like domain 17 98 2.7E-12 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 44 148 4.1E-28 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 185 712 2.7E-109 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.30.365.10 641 766 3.8E-43 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.30.365.10 370 473 3.8E-43 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 SUPERFAMILY SSF56003 150 766 1.31E-120 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 SMART SM01008 43 149 1.6E-43 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.30.365.10 492 640 1.9E-20 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 SUPERFAMILY SSF54665 25 150 2.36E-38 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.90.1170.50 23 137 3.6E-39 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.30.365.10 200 290 6.1E-21 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.30.365.10 293 367 4.3E-28 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS23640 a1c849b00b29fd61a568aee5420587ae 773 Gene3D G3DSA:3.30.365.10 138 197 4.3E-28 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS44790 2bf61307cc620696af9d5ca7b7bd35b1 171 Gene3D G3DSA:1.20.120.450 3 169 1.1E-41 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS44790 2bf61307cc620696af9d5ca7b7bd35b1 171 Pfam PF04978 Protein of unknown function (DUF664) 18 166 4.6E-41 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS44790 2bf61307cc620696af9d5ca7b7bd35b1 171 SUPERFAMILY SSF109854 3 165 4.27E-41 T 17-03-2017 SHXM_RS17050 7e60f3fc377562c82e324b41f677a5ae 361 SUPERFAMILY SSF51735 5 158 1.6E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17050 7e60f3fc377562c82e324b41f677a5ae 361 Gene3D G3DSA:3.40.50.720 2 171 1.4E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17050 7e60f3fc377562c82e324b41f677a5ae 361 SUPERFAMILY SSF55021 294 355 1.83E-5 T 17-03-2017 SHXM_RS17050 7e60f3fc377562c82e324b41f677a5ae 361 SUPERFAMILY SSF48179 166 251 2.72E-22 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS17050 7e60f3fc377562c82e324b41f677a5ae 361 Pfam PF02153 Prephenate dehydrogenase 18 250 1.1E-57 T 17-03-2017 IPR003099 Prephenate dehydrogenase GO:0004665|GO:0006571|GO:0008977|GO:0055114 KEGG: 00400+1.3.1.12|KEGG: 00401+1.3.1.12|MetaCyc: PWY-7303 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 Pfam PF00067 Cytochrome P450 189 384 3.3E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 Gene3D G3DSA:1.10.630.10 14 415 1.1E-128 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 355 364 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 142 158 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 332 347 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 159 174 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 304 331 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 353 362 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 362 373 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 95 106 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00359 B-class P450 signature 196 218 1.3E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00385 P450 superfamily signature 251 268 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00385 P450 superfamily signature 286 297 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00385 P450 superfamily signature 353 362 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 PRINTS PR00385 P450 superfamily signature 362 373 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03975 e5771ac63fdaad422ce181008af207cb 418 SUPERFAMILY SSF48264 16 414 3.8E-98 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS14105 aaa444eb13503780af85140e91ec5653 106 Gene3D G3DSA:3.40.309.10 21 75 7.6E-4 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS39140 d5ae649b9f31b9ea6d33474560f26de2 247 Pfam PF00005 ABC transporter 23 171 7.7E-36 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS39140 d5ae649b9f31b9ea6d33474560f26de2 247 PIRSF PIRSF039085 4 247 2.7E-111 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS39140 d5ae649b9f31b9ea6d33474560f26de2 247 Gene3D G3DSA:3.40.50.300 6 243 1.5E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39140 d5ae649b9f31b9ea6d33474560f26de2 247 ProSitePatterns PS00211 ABC transporters family signature. 143 157 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS39140 d5ae649b9f31b9ea6d33474560f26de2 247 SUPERFAMILY SSF52540 7 241 2.04E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39140 d5ae649b9f31b9ea6d33474560f26de2 247 SMART SM00382 32 226 3.9E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 SUPERFAMILY SSF51735 116 242 4.4E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 SUPERFAMILY SSF50129 1 142 2.89E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 SMART SM00829 10 308 1.3E-39 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 Gene3D G3DSA:3.40.50.720 150 234 6.6E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 144 165 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 Pfam PF13602 Zinc-binding dehydrogenase 187 308 4.4E-28 T 17-03-2017 SHXM_RS47345 5d44f0431c68520bdcf275f436537bd7 310 Gene3D G3DSA:3.90.180.10 1 149 2.3E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS36685 8647e03b6064117fab8b098084beff0c 357 Gene3D G3DSA:3.40.190.10 7 134 4.8E-24 T 17-03-2017 SHXM_RS36685 8647e03b6064117fab8b098084beff0c 357 Gene3D G3DSA:3.40.190.10 288 345 4.8E-24 T 17-03-2017 SHXM_RS36685 8647e03b6064117fab8b098084beff0c 357 SUPERFAMILY SSF53850 36 355 3.39E-50 T 17-03-2017 SHXM_RS36685 8647e03b6064117fab8b098084beff0c 357 Pfam PF13343 Bacterial extracellular solute-binding protein 87 321 1.4E-21 T 17-03-2017 SHXM_RS36685 8647e03b6064117fab8b098084beff0c 357 TIGRFAM TIGR01254 sfuA: ABC transporter periplasmic binding protein, thiB subfamily 36 352 5.4E-70 T 17-03-2017 IPR005948 Thiamine ABC transporter periplasmic binding protein GO:0005215|GO:0006810|GO:0015888|GO:0030288|GO:0030975 SHXM_RS36685 8647e03b6064117fab8b098084beff0c 357 Gene3D G3DSA:3.40.190.10 140 287 8.0E-21 T 17-03-2017 SHXM_RS27015 a8453c47de36dfe049a38f7bbe6fe5a3 156 Gene3D G3DSA:3.30.1330.40 5 154 7.7E-68 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS27015 a8453c47de36dfe049a38f7bbe6fe5a3 156 Pfam PF14588 YjgF/chorismate_mutase-like, putative endoribonuclease 7 153 3.3E-34 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS27015 a8453c47de36dfe049a38f7bbe6fe5a3 156 SUPERFAMILY SSF55298 5 154 1.73E-56 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 Pfam PF02769 AIR synthase related protein, C-terminal domain 178 341 4.3E-30 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 TIGRFAM TIGR00878 purM: phosphoribosylformylglycinamidine cyclo-ligase 7 338 1.1E-124 T 17-03-2017 IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase GO:0004641|GO:0005737|GO:0006189 KEGG: 00230+6.3.3.1|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 Gene3D G3DSA:3.30.1330.10 22 170 4.4E-49 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 Hamap MF_00741 Phosphoribosylformylglycinamidine cyclo-ligase [purM]. 6 349 40.038 T 17-03-2017 IPR004733 Phosphoribosylformylglycinamidine cyclo-ligase GO:0004641|GO:0005737|GO:0006189 KEGG: 00230+6.3.3.1|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277|Reactome: R-HSA-73817 SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 Gene3D G3DSA:3.90.650.10 174 344 5.7E-62 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 Pfam PF00586 AIR synthase related protein, N-terminal domain 61 165 1.5E-15 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 SUPERFAMILY SSF56042 174 340 3.59E-51 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29415 d813a0dbfc3e06ccc4a609bd8aa2eb23 355 SUPERFAMILY SSF55326 7 170 4.49E-43 T 17-03-2017 SHXM_RS38720 bf9344a096e8fe260f1f02e6d480c197 379 Gene3D G3DSA:3.40.190.10 161 278 2.0E-15 T 17-03-2017 SHXM_RS38720 bf9344a096e8fe260f1f02e6d480c197 379 SUPERFAMILY SSF53850 62 293 4.92E-34 T 17-03-2017 SHXM_RS38720 bf9344a096e8fe260f1f02e6d480c197 379 TIGRFAM TIGR01728 SsuA_fam: ABC transporter, substrate-binding protein, aliphatic sulfonates family 63 359 4.0E-50 T 17-03-2017 IPR010067 Aliphatic sulfonates-binding protein GO:0006790|GO:0006810|GO:0016020 SHXM_RS38720 bf9344a096e8fe260f1f02e6d480c197 379 Gene3D G3DSA:3.40.190.10 89 160 2.0E-4 T 17-03-2017 SHXM_RS38720 bf9344a096e8fe260f1f02e6d480c197 379 Pfam PF13379 NMT1-like family 61 298 5.7E-23 T 17-03-2017 SHXM_RS02540 a8dbfbf648a40b1c2bfca4ea856e5789 68 Gene3D G3DSA:1.10.357.10 2 63 5.1E-8 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS02540 a8dbfbf648a40b1c2bfca4ea856e5789 68 Pfam PF13977 Bacterial transcriptional repressor 2 63 6.1E-11 T 17-03-2017 SHXM_RS02540 a8dbfbf648a40b1c2bfca4ea856e5789 68 SUPERFAMILY SSF48498 2 59 7.07E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS06905 60df7ffa140bfa034ca1b886f805b216 334 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 124 330 1.0E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06905 60df7ffa140bfa034ca1b886f805b216 334 SUPERFAMILY SSF161098 87 318 4.32E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06905 60df7ffa140bfa034ca1b886f805b216 334 Gene3D G3DSA:1.10.3720.10 102 328 1.2E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 Pfam PF00252 Ribosomal protein L16p/L10e 4 132 3.5E-47 T 17-03-2017 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 PRINTS PR00060 Ribosomal protein L16 signature 88 117 2.9E-38 T 17-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 PRINTS PR00060 Ribosomal protein L16 signature 58 87 2.9E-38 T 17-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 PRINTS PR00060 Ribosomal protein L16 signature 24 36 2.9E-38 T 17-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 PRINTS PR00060 Ribosomal protein L16 signature 42 53 2.9E-38 T 17-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 ProSitePatterns PS00586 Ribosomal protein L16 signature 1. 59 70 - T 17-03-2017 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 ProSitePatterns PS00701 Ribosomal protein L16 signature 2. 82 93 - T 17-03-2017 IPR020798 Ribosomal protein L16, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 Gene3D G3DSA:3.90.1170.10 23 136 1.3E-52 T 17-03-2017 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 TIGRFAM TIGR01164 rplP_bact: ribosomal protein uL16 2 127 3.0E-54 T 17-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 Hamap MF_01342 50S ribosomal protein L16 [rplP]. 1 134 37.821 T 17-03-2017 IPR000114 Ribosomal protein L16 GO:0003735|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31200 94d69f270ea0de017fa915520770823f 139 SUPERFAMILY SSF54686 1 135 3.66E-55 T 17-03-2017 IPR016180 Ribosomal protein L10e/L16 GO:0003735|GO:0005840|GO:0006412 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 239 275 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 TIGRFAM TIGR02407 ectoine_ectB: diaminobutyrate--2-oxoglutarate aminotransferase 10 417 1.7E-199 T 17-03-2017 IPR012773 Ectoine biosynthetic protein GO:0019491|GO:0030170|GO:0047307 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 Gene3D G3DSA:3.40.640.10 95 318 3.3E-61 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 Pfam PF00202 Aminotransferase class-III 27 415 1.8E-75 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 Gene3D G3DSA:3.90.1150.10 21 61 2.2E-31 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 Gene3D G3DSA:3.90.1150.10 324 418 2.2E-31 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 TIGRFAM TIGR00709 dat: 2,4-diaminobutyrate 4-transaminase 8 419 2.4E-134 T 17-03-2017 IPR004637 2,4-diaminobutyrate 4-transaminase GO:0008483|GO:0009058 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 SHXM_RS17580 60c3281dc7de299fd4aff6a11d65bfab 420 SUPERFAMILY SSF53383 15 417 1.55E-105 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS50300 2f16fc05fc509ee7562d2687c4cfa851 251 SUPERFAMILY SSF52540 3 246 1.2E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50300 2f16fc05fc509ee7562d2687c4cfa851 251 PIRSF PIRSF039085 1 251 2.6E-115 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS50300 2f16fc05fc509ee7562d2687c4cfa851 251 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS50300 2f16fc05fc509ee7562d2687c4cfa851 251 Pfam PF00005 ABC transporter 18 176 4.5E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS50300 2f16fc05fc509ee7562d2687c4cfa851 251 Gene3D G3DSA:3.40.50.300 2 248 1.1E-85 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50300 2f16fc05fc509ee7562d2687c4cfa851 251 SMART SM00382 27 224 6.7E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 Gene3D G3DSA:3.40.800.20 4 351 9.3E-90 T 17-03-2017 IPR023801 Histone deacetylase domain Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 Pfam PF00850 Histone deacetylase domain 22 317 3.6E-69 T 17-03-2017 IPR023801 Histone deacetylase domain Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 PRINTS PR01270 Histone deacetylase superfamily signature 161 176 1.6E-17 T 17-03-2017 IPR000286 Histone deacetylase superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 PRINTS PR01270 Histone deacetylase superfamily signature 247 257 1.6E-17 T 17-03-2017 IPR000286 Histone deacetylase superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 PRINTS PR01270 Histone deacetylase superfamily signature 128 151 1.6E-17 T 17-03-2017 IPR000286 Histone deacetylase superfamily Reactome: R-HSA-2122947|Reactome: R-HSA-2644606|Reactome: R-HSA-2894862 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 SUPERFAMILY SSF52768 6 345 2.4E-101 T 17-03-2017 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 PRINTS PR01272 Acetoin utilisation ACUC protein signature 105 118 9.2E-7 T 17-03-2017 IPR003085 Acetoin utilization protein AcuC GO:0045149 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 PRINTS PR01272 Acetoin utilisation ACUC protein signature 16 36 9.2E-7 T 17-03-2017 IPR003085 Acetoin utilization protein AcuC GO:0045149 SHXM_RS30405 c29aad1cc85df2b9121d5d0853a86a52 390 PRINTS PR01272 Acetoin utilisation ACUC protein signature 84 98 9.2E-7 T 17-03-2017 IPR003085 Acetoin utilization protein AcuC GO:0045149 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00385 P450 superfamily signature 389 398 5.2E-14 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00385 P450 superfamily signature 265 282 5.2E-14 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00385 P450 superfamily signature 317 328 5.2E-14 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00385 P450 superfamily signature 398 409 5.2E-14 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 Gene3D G3DSA:1.10.630.10 15 450 6.5E-108 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 Pfam PF00067 Cytochrome P450 13 436 4.9E-75 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 SUPERFAMILY SSF48264 15 449 3.41E-102 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00463 E-class P450 group I signature 274 300 2.3E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00463 E-class P450 group I signature 388 398 2.3E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00463 E-class P450 group I signature 356 380 2.3E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00463 E-class P450 group I signature 39 58 2.3E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00463 E-class P450 group I signature 254 271 2.3E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 PRINTS PR00463 E-class P450 group I signature 398 421 2.3E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03055 4d8d94fe0f6b775e59cae373eb0966cf 486 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 391 400 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS41930 bc8fb2140a2f1d276df4427875f19d62 221 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 72 1.2E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41930 bc8fb2140a2f1d276df4427875f19d62 221 SUPERFAMILY SSF46689 15 100 1.05E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41930 bc8fb2140a2f1d276df4427875f19d62 221 Gene3D G3DSA:1.10.357.10 18 205 7.7E-44 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41930 bc8fb2140a2f1d276df4427875f19d62 221 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 42 8.6E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41930 bc8fb2140a2f1d276df4427875f19d62 221 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 49 72 8.6E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41930 bc8fb2140a2f1d276df4427875f19d62 221 SUPERFAMILY SSF48498 94 196 3.11E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS24610 6a8585a262a9e18898709772a07eb75d 332 Gene3D G3DSA:1.10.287.1080 132 203 2.0E-11 T 17-03-2017 SHXM_RS24610 6a8585a262a9e18898709772a07eb75d 332 SUPERFAMILY SSF101386 133 229 1.24E-21 T 17-03-2017 SHXM_RS24610 6a8585a262a9e18898709772a07eb75d 332 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 152 226 3.9E-25 T 17-03-2017 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core SHXM_RS17755 ee0b3b24856cc12d8f813c49444531be 316 SUPERFAMILY SSF103481 187 288 6.28E-11 T 17-03-2017 SHXM_RS17755 ee0b3b24856cc12d8f813c49444531be 316 SUPERFAMILY SSF103481 40 140 2.09E-12 T 17-03-2017 SHXM_RS17755 ee0b3b24856cc12d8f813c49444531be 316 Pfam PF00892 EamA-like transporter family 165 282 1.5E-8 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS17755 ee0b3b24856cc12d8f813c49444531be 316 Pfam PF00892 EamA-like transporter family 7 137 3.5E-14 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 Gene3D G3DSA:1.10.10.10 13 81 2.0E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 SMART SM00346 13 103 7.8E-11 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 SUPERFAMILY SSF46785 14 84 1.64E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 Pfam PF01614 Bacterial transcriptional regulator 133 251 1.5E-15 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 SUPERFAMILY SSF55781 71 252 5.56E-33 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 Gene3D G3DSA:3.30.450.40 91 256 9.0E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS35815 ed6e2b06063fe568b40a7e99498ca89d 267 Pfam PF09339 IclR helix-turn-helix domain 16 65 1.6E-12 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Gene3D G3DSA:1.20.272.10 258 356 3.2E-44 T 17-03-2017 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Gene3D G3DSA:3.40.50.300 11 170 4.8E-30 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 69 88 3.8E-5 T 17-03-2017 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 PRINTS PR00830 Endopeptidase La (Lon) serine protease (S16) signature 452 462 3.8E-5 T 17-03-2017 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Pfam PF16193 AAA C-terminal domain 200 276 1.3E-24 T 17-03-2017 IPR032423 AAA ATPase, C-terminal domain SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Gene3D G3DSA:1.10.3710.10 357 445 9.6E-28 T 17-03-2017 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 65 169 4.1E-13 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Gene3D G3DSA:1.10.8.60 178 233 1.3E-6 T 17-03-2017 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 SUPERFAMILY SSF48019 262 444 1.02E-72 T 17-03-2017 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 SUPERFAMILY SSF52540 20 245 5.44E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 Pfam PF12002 MgsA AAA+ ATPase C terminal 277 442 3.6E-68 T 17-03-2017 IPR021886 MgsA AAA+ ATPase C-terminal SHXM_RS12465 4b558f349a8da8db618606c3ee6f289b 462 SMART SM00382 61 182 3.0E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 SMART SM00862 145 219 7.8E-22 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 SUPERFAMILY SSF46894 120 220 1.05E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 219 6.6E-20 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 Gene3D G3DSA:3.40.50.2300 2 120 5.1E-37 T 17-03-2017 SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 Gene3D G3DSA:1.10.10.10 122 221 5.6E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 SUPERFAMILY SSF52172 2 132 2.28E-37 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 Pfam PF00072 Response regulator receiver domain 3 112 8.8E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20535 982d657903f9f04990221f97962c80ba 226 SMART SM00448 1 112 1.1E-35 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS42075 8713723cd4a22e6a08400f31e23bdee0 220 SUPERFAMILY SSF103473 3 190 9.81E-25 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS42075 8713723cd4a22e6a08400f31e23bdee0 220 Pfam PF07690 Major Facilitator Superfamily 8 187 6.2E-16 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS42075 8713723cd4a22e6a08400f31e23bdee0 220 Gene3D G3DSA:1.20.1250.20 4 185 1.8E-23 T 17-03-2017 SHXM_RS34545 8c28cd0da5152e54dd3b0ebc20f65c12 286 SUPERFAMILY SSF47413 10 72 1.58E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS34545 8c28cd0da5152e54dd3b0ebc20f65c12 286 Gene3D G3DSA:1.10.260.40 3 72 4.9E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS34545 8c28cd0da5152e54dd3b0ebc20f65c12 286 SMART SM00530 17 72 1.5E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS34545 8c28cd0da5152e54dd3b0ebc20f65c12 286 Pfam PF13560 Helix-turn-helix domain 13 75 1.3E-10 T 17-03-2017 SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Pfam PF00580 UvrD/REP helicase N-terminal domain 43 322 1.7E-49 T 17-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Pfam PF12705 PD-(D/E)XK nuclease superfamily 837 1089 1.9E-37 T 17-03-2017 SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Pfam PF13361 UvrD-like helicase C-terminal domain 600 731 7.0E-21 T 17-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Gene3D G3DSA:3.40.50.300 225 325 4.3E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Gene3D G3DSA:3.40.50.300 42 179 4.3E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Gene3D G3DSA:3.40.50.300 338 458 2.7E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 Gene3D G3DSA:3.40.50.300 649 747 2.7E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 SUPERFAMILY SSF52540 538 747 5.7E-104 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34275 64ae44c896a140b0c9eacaf9f0eec878 1100 SUPERFAMILY SSF52540 39 502 5.7E-104 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 SMART SM00342 272 355 1.6E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 Pfam PF12625 Arabinose-binding domain of AraC transcription regulator, N-term 24 215 1.3E-48 T 17-03-2017 IPR032687 HTH-type transcriptional regulator AraC-type, N-terminal SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 Pfam PF12833 Helix-turn-helix domain 279 356 1.0E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 339 355 2.7E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 324 339 2.7E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 SUPERFAMILY SSF46689 308 358 8.96E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30695 b2b1a2403dfe34d4aff09dd085c93f41 363 Gene3D G3DSA:1.10.10.60 308 357 4.3E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09440 726bc5436d042b5df9230c18063d53b6 192 Pfam PF00589 Phage integrase family 23 155 1.3E-12 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS09440 726bc5436d042b5df9230c18063d53b6 192 SUPERFAMILY SSF56349 22 164 1.68E-23 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS09440 726bc5436d042b5df9230c18063d53b6 192 Gene3D G3DSA:1.10.443.10 23 161 1.3E-23 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 Pfam PF13537 Glutamine amidotransferase domain 48 169 6.0E-45 T 17-03-2017 IPR017932 Glutamine amidotransferase type 2 domain SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 PIRSF PIRSF001589 1 604 7.0E-134 T 17-03-2017 SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 TIGRFAM TIGR01536 asn_synth_AEB: asparagine synthase (glutamine-hydrolyzing) 2 536 2.5E-145 T 17-03-2017 IPR006426 Asparagine synthase, glutamine-hydrolyzing GO:0004066|GO:0006529 KEGG: 00250+6.3.5.4|Reactome: R-HSA-380994|Reactome: R-HSA-70614 SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 Pfam PF00733 Asparagine synthase 240 600 2.4E-81 T 17-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 SUPERFAMILY SSF56235 2 224 1.08E-61 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 Gene3D G3DSA:3.60.20.10 2 223 4.7E-72 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 Gene3D G3DSA:3.40.50.620 224 400 1.6E-73 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 Gene3D G3DSA:3.40.50.620 460 589 1.6E-73 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 SUPERFAMILY SSF52402 456 560 3.7E-62 T 17-03-2017 SHXM_RS45675 8bb72e8c3cc67a2cdb78de525b710d17 610 SUPERFAMILY SSF52402 228 396 3.7E-62 T 17-03-2017 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 SUPERFAMILY SSF52242 512 655 2.09E-43 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 Pfam PF01642 Methylmalonyl-CoA mutase 8 492 2.7E-131 T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 533 661 1.7E-38 T 17-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 Gene3D G3DSA:3.40.50.280 514 659 3.5E-49 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 Gene3D G3DSA:3.20.20.240 7 494 3.0E-186 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 Pfam PF02310 B12 binding domain 536 642 5.3E-17 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 SUPERFAMILY SSF51703 6 494 1.94E-161 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS14735 bc5b4844950a6e74452ab2691cf714f6 672 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 9 498 3.4E-138 T 17-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS18675 de200b1f4ace0a65c19781dfb11330a2 217 Pfam PF02581 Thiamine monophosphate synthase/TENI 16 197 3.8E-53 T 17-03-2017 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SHXM_RS18675 de200b1f4ace0a65c19781dfb11330a2 217 Hamap MF_00097 Thiamine-phosphate synthase [thiE]. 13 215 24.501 T 17-03-2017 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SHXM_RS18675 de200b1f4ace0a65c19781dfb11330a2 217 SUPERFAMILY SSF51391 9 212 2.35E-61 T 17-03-2017 IPR022998 Thiamin phosphate synthase superfamily KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SHXM_RS18675 de200b1f4ace0a65c19781dfb11330a2 217 TIGRFAM TIGR00693 thiE: thiamine-phosphate diphosphorylase 15 210 2.7E-60 T 17-03-2017 IPR003733 Thiamine phosphate synthase GO:0004789|GO:0009228 KEGG: 00730+2.5.1.3|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6897|MetaCyc: PWY-6907|MetaCyc: PWY-6908|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SHXM_RS18675 de200b1f4ace0a65c19781dfb11330a2 217 Gene3D G3DSA:3.20.20.70 6 215 6.1E-73 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS35370 43270885737fca078254a87327ef35da 150 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 6 122 1.0E-19 T 17-03-2017 SHXM_RS35370 43270885737fca078254a87327ef35da 150 SUPERFAMILY SSF54593 1 139 7.15E-33 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS35370 43270885737fca078254a87327ef35da 150 Gene3D G3DSA:3.10.180.10 1 136 5.3E-36 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS35370 43270885737fca078254a87327ef35da 150 TIGRFAM TIGR03081 metmalonyl_epim: methylmalonyl-CoA epimerase 4 136 6.3E-42 T 17-03-2017 IPR017515 Methylmalonyl-CoA epimerase KEGG: 00280+5.1.99.1|KEGG: 00630+5.1.99.1|KEGG: 00640+5.1.99.1|KEGG: 00720+5.1.99.1|MetaCyc: PWY-5741|MetaCyc: PWY-5743|MetaCyc: PWY-5789|MetaCyc: PWY-6728|MetaCyc: PWY-7384|Reactome: R-HSA-71032 SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 Gene3D G3DSA:3.40.50.970 2 180 7.6E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 SUPERFAMILY SSF52467 183 346 1.9E-40 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 192 319 6.5E-29 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 Gene3D G3DSA:3.40.50.1220 186 341 2.9E-38 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 Gene3D G3DSA:3.40.50.970 356 556 1.3E-55 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 383 529 1.1E-39 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 5 171 9.8E-41 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 SUPERFAMILY SSF52518 360 552 4.72E-57 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38810 a8ac620d985d9b47119f48084e32162c 580 SUPERFAMILY SSF52518 1 175 1.14E-39 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 SUPERFAMILY SSF51645 20 538 1.44E-181 T 17-03-2017 IPR011076 Malate synthase-like GO:0003824 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 Gene3D G3DSA:1.20.1220.12 419 532 3.8E-26 T 17-03-2017 SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 TIGRFAM TIGR01344 malate_syn_A: malate synthase A 23 538 4.9E-251 T 17-03-2017 IPR006252 Malate synthase A GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 Gene3D G3DSA:3.20.20.360 72 415 2.1E-117 T 17-03-2017 SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 Pfam PF01274 Malate synthase 18 538 1.5E-200 T 17-03-2017 IPR001465 Malate synthase GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 ProSitePatterns PS00510 Malate synthase signature. 269 284 - T 17-03-2017 IPR019830 Malate synthase, conserved site GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS38970 b94fd330aa650aefd69ecf97a396bb8c 539 PIRSF PIRSF001363 3 539 1.3E-239 T 17-03-2017 IPR006252 Malate synthase A GO:0004474|GO:0006097 KEGG: 00620+2.3.3.9|KEGG: 00630+2.3.3.9|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7118|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 PRINTS PR00050 Cold shock protein signature 24 33 1.2E-19 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 PRINTS PR00050 Cold shock protein signature 39 57 1.2E-19 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 PRINTS PR00050 Cold shock protein signature 4 19 1.2E-19 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 SUPERFAMILY SSF50249 1 64 9.31E-25 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 Gene3D G3DSA:2.40.50.140 1 65 1.5E-32 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 33 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 PIRSF PIRSF002599 1 67 5.9E-26 T 17-03-2017 IPR012156 Cold shock, CspA GO:0003676 SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 SMART SM00357 3 66 6.2E-31 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS25850 b8512af95ff5d56003efcab40218a397 68 Pfam PF00313 'Cold-shock' DNA-binding domain 3 64 5.7E-31 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 15 71 6.0E-9 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 48 56 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 Gene3D G3DSA:3.10.20.30 11 84 1.6E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 Gene3D G3DSA:1.10.150.120 85 186 1.5E-27 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 SUPERFAMILY SSF47741 96 184 7.2E-26 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 Pfam PF01799 [2Fe-2S] binding domain 83 176 1.6E-26 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS06260 1f7238cbcbf114449244f7d1b6a5fd8a 195 SUPERFAMILY SSF54292 14 86 2.1E-24 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 83 1.8E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 SUPERFAMILY SSF46785 16 87 3.86E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 Pfam PF00155 Aminotransferase class I and II 150 460 7.1E-34 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 57 73 1.1E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 43 57 1.1E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 Gene3D G3DSA:1.10.10.10 17 84 5.3E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 SMART SM00345 24 83 1.5E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 Gene3D G3DSA:3.90.1150.10 353 463 1.8E-12 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 SUPERFAMILY SSF53383 133 464 1.18E-79 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS09530 53331a689fad8b58779992c0e0185ba8 481 Gene3D G3DSA:3.40.640.10 148 352 4.3E-59 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS16905 8d4d9ee3feff79cb6ccbf2735b0f6d4d 433 PIRSF PIRSF000337 1 433 2.2E-144 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS16905 8d4d9ee3feff79cb6ccbf2735b0f6d4d 433 Pfam PF00296 Luciferase-like monooxygenase 27 378 7.7E-56 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16905 8d4d9ee3feff79cb6ccbf2735b0f6d4d 433 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 16 423 8.7E-124 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS16905 8d4d9ee3feff79cb6ccbf2735b0f6d4d 433 SUPERFAMILY SSF51679 5 429 9.55E-110 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16905 8d4d9ee3feff79cb6ccbf2735b0f6d4d 433 Gene3D G3DSA:3.20.20.30 344 429 2.1E-120 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16905 8d4d9ee3feff79cb6ccbf2735b0f6d4d 433 Gene3D G3DSA:3.20.20.30 3 294 2.1E-120 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS10915 c22b276b33e6794841cc617d3a09dd8e 258 SUPERFAMILY SSF52540 19 222 3.77E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10915 c22b276b33e6794841cc617d3a09dd8e 258 Gene3D G3DSA:3.40.50.300 18 215 1.8E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10915 c22b276b33e6794841cc617d3a09dd8e 258 SMART SM00382 43 209 2.8E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS10915 c22b276b33e6794841cc617d3a09dd8e 258 ProSitePatterns PS00211 ABC transporters family signature. 132 146 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS10915 c22b276b33e6794841cc617d3a09dd8e 258 Pfam PF00005 ABC transporter 37 159 5.2E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF55048 688 748 4.58E-5 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.30.70.250 691 742 5.4E-4 T 17-03-2017 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.40.47.10 17 317 8.5E-70 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 218 234 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 587 866 1.9E-12 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Pfam PF14765 Polyketide synthase dehydratase 1060 1311 3.7E-17 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 15 305 1.9E-59 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.90.470.20 1448 1538 8.5E-9 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.40.366.10 749 860 4.3E-25 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.40.366.10 638 690 4.3E-25 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.40.47.10 318 482 1.5E-51 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Pfam PF00698 Acyl transferase domain 642 828 4.5E-16 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 436 510 1.8E-8 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF53901 459 480 1.5E-70 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF53901 200 427 1.5E-70 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF53901 13 141 1.5E-70 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 1448 1517 1.2E-9 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF56214 1347 1444 7.85E-11 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SMART SM00825 Beta-ketoacyl synthase 17 484 8.8E-97 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF52151 751 853 6.28E-30 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF52151 583 689 6.28E-30 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 313 431 1.6E-33 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 SUPERFAMILY SSF56214 1447 1538 8.55E-12 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS40755 d507bb7170837101e8e8e2a0ab729d0b 1572 Gene3D G3DSA:3.90.470.20 1349 1443 1.2E-10 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS27390 0382dc19206a50df6db321252a942400 283 Gene3D G3DSA:2.40.128.110 107 277 2.2E-53 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS27390 0382dc19206a50df6db321252a942400 283 SMART SM00867 107 275 7.2E-62 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS27390 0382dc19206a50df6db321252a942400 283 SUPERFAMILY SSF49452 10 91 9.61E-7 T 17-03-2017 IPR013784 Carbohydrate-binding-like fold GO:0030246 SHXM_RS27390 0382dc19206a50df6db321252a942400 283 Pfam PF04264 YceI-like domain 108 274 1.3E-37 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS27390 0382dc19206a50df6db321252a942400 283 Gene3D G3DSA:2.60.40.1120 15 97 1.5E-6 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS27390 0382dc19206a50df6db321252a942400 283 SUPERFAMILY SSF101874 108 277 1.44E-48 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS09640 468787e44101927cd3ddd7dcc1c22090 125 SUPERFAMILY SSF46785 23 116 1.32E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09640 468787e44101927cd3ddd7dcc1c22090 125 Pfam PF01638 HxlR-like helix-turn-helix 23 110 2.3E-17 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS09640 468787e44101927cd3ddd7dcc1c22090 125 Gene3D G3DSA:1.10.10.10 22 117 2.8E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43245 061e371618042da9b813bb3f5bb357c4 409 Gene3D G3DSA:3.30.420.40 235 379 2.0E-34 T 17-03-2017 SHXM_RS43245 061e371618042da9b813bb3f5bb357c4 409 Gene3D G3DSA:1.10.10.10 19 79 2.4E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43245 061e371618042da9b813bb3f5bb357c4 409 Pfam PF00480 ROK family 96 394 1.4E-31 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS43245 061e371618042da9b813bb3f5bb357c4 409 SUPERFAMILY SSF53067 84 217 1.3E-12 T 17-03-2017 SHXM_RS43245 061e371618042da9b813bb3f5bb357c4 409 SUPERFAMILY SSF53067 226 403 5.83E-32 T 17-03-2017 SHXM_RS43245 061e371618042da9b813bb3f5bb357c4 409 Gene3D G3DSA:3.30.420.40 81 234 4.6E-24 T 17-03-2017 SHXM_RS06325 498821ddc3e03a574e33cdb313fc127a 176 Pfam PF02342 TerD domain 5 163 1.4E-20 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS06325 498821ddc3e03a574e33cdb313fc127a 176 Gene3D G3DSA:2.60.60.30 6 167 1.9E-41 T 17-03-2017 SHXM_RS43130 238b61cc988ea1d847848de3672d8b96 261 SUPERFAMILY SSF52402 3 255 7.99E-71 T 17-03-2017 SHXM_RS43130 238b61cc988ea1d847848de3672d8b96 261 PIRSF PIRSF000090 3 261 1.8E-81 T 17-03-2017 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 Reactome: R-HSA-611105 SHXM_RS43130 238b61cc988ea1d847848de3672d8b96 261 Gene3D G3DSA:3.40.50.620 3 260 9.4E-86 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43130 238b61cc988ea1d847848de3672d8b96 261 SMART SM00893 24 214 1.3E-57 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS43130 238b61cc988ea1d847848de3672d8b96 261 Pfam PF01012 Electron transfer flavoprotein domain 25 209 7.1E-47 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS10610 238b61cc988ea1d847848de3672d8b96 261 SUPERFAMILY SSF52402 3 255 7.99E-71 T 17-03-2017 SHXM_RS10610 238b61cc988ea1d847848de3672d8b96 261 PIRSF PIRSF000090 3 261 1.8E-81 T 17-03-2017 IPR012255 Electron transfer flavoprotein, beta subunit GO:0009055 Reactome: R-HSA-611105 SHXM_RS10610 238b61cc988ea1d847848de3672d8b96 261 Gene3D G3DSA:3.40.50.620 3 260 9.4E-86 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS10610 238b61cc988ea1d847848de3672d8b96 261 SMART SM00893 24 214 1.3E-57 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS10610 238b61cc988ea1d847848de3672d8b96 261 Pfam PF01012 Electron transfer flavoprotein domain 25 209 7.1E-47 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 SUPERFAMILY SSF55961 169 374 3.38E-42 T 17-03-2017 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 Gene3D G3DSA:2.102.10.10 41 148 1.2E-36 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 Pfam PF00355 Rieske [2Fe-2S] domain 42 127 2.9E-18 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 SUPERFAMILY SSF50022 17 155 1.44E-43 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 Gene3D G3DSA:3.90.380.10 149 377 4.4E-21 T 17-03-2017 IPR015879 Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain GO:0005506|GO:0016708|GO:0019439|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 140 166 2.2E-22 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 184 206 2.2E-22 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 56 71 2.2E-22 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 77 97 2.2E-22 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 26 51 2.2E-22 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 99 119 2.2E-22 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS43755 5d38eecdf6be418f7d08d7c277992df5 385 Pfam PF00848 Ring hydroxylating alpha subunit (catalytic domain) 189 376 1.6E-45 T 17-03-2017 IPR015879 Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain GO:0005506|GO:0016708|GO:0019439|GO:0051537|GO:0055114 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 10 96 3.1E-15 T 17-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 Gene3D G3DSA:2.60.40.1180 599 712 1.6E-32 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 SUPERFAMILY SSF51445 499 585 4.01E-130 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 SUPERFAMILY SSF51445 133 470 4.01E-130 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 SUPERFAMILY SSF81296 5 147 7.0E-42 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 Gene3D G3DSA:2.60.40.10 5 151 7.6E-52 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 Gene3D G3DSA:3.20.20.80 152 585 4.8E-118 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 TIGRFAM TIGR02100 glgX_debranch: glycogen debranching enzyme GlgX 6 711 1.8E-295 T 17-03-2017 IPR011837 Glycogen debranching enzyme, GlgX type GO:0004133|GO:0004553|GO:0005980 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 SUPERFAMILY SSF51011 600 711 7.19E-24 T 17-03-2017 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 Pfam PF00128 Alpha amylase, catalytic domain 189 275 1.9E-5 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 Pfam PF00128 Alpha amylase, catalytic domain 297 530 6.6E-5 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS38525 9768e1ace533f00b6fe04126bbc08f5d 714 SMART SM00642 177 558 1.1E-7 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 Gene3D G3DSA:3.40.190.10 288 331 1.2E-26 T 17-03-2017 SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 Gene3D G3DSA:3.40.190.10 97 180 1.2E-26 T 17-03-2017 SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 122 135 - T 17-03-2017 IPR018313 Solute-binding protein family 3, conserved site GO:0005215|GO:0006810 SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 Gene3D G3DSA:3.40.190.10 181 287 1.2E-21 T 17-03-2017 SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 SUPERFAMILY SSF53850 97 327 1.45E-48 T 17-03-2017 SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 SMART SM00062 98 330 4.4E-50 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS21945 7f8eca1baf1f1aaf26d6fba4c2d031f0 347 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 99 327 1.4E-46 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 Gene3D G3DSA:2.30.38.10 325 403 2.8E-21 T 17-03-2017 SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 Gene3D G3DSA:3.40.50.980 18 170 1.2E-27 T 17-03-2017 SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 SUPERFAMILY SSF56801 12 497 1.96E-115 T 17-03-2017 SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 Gene3D G3DSA:3.40.50.980 171 324 1.4E-30 T 17-03-2017 SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 Pfam PF00501 AMP-binding enzyme 23 412 2.0E-80 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 ProSitePatterns PS00455 Putative AMP-binding domain signature. 162 173 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS15435 27a2fc75fdbbb142e29265bbf8d05d7e 502 Gene3D G3DSA:3.30.300.30 407 497 1.7E-12 T 17-03-2017 SHXM_RS49375 59102ab189f3f42cdf55229ea6d898d5 747 Gene3D G3DSA:1.10.260.40 25 72 3.9E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49375 59102ab189f3f42cdf55229ea6d898d5 747 SMART SM00530 23 77 9.8E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49375 59102ab189f3f42cdf55229ea6d898d5 747 Pfam PF01381 Helix-turn-helix 25 61 4.3E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49375 59102ab189f3f42cdf55229ea6d898d5 747 SUPERFAMILY SSF47413 25 71 7.24E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 190 202 1.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 160 174 1.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 174 190 1.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 SMART SM00448 5 119 4.2E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 Pfam PF00072 Response regulator receiver domain 7 119 4.6E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 SUPERFAMILY SSF52172 4 191 1.1E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 ProSitePatterns PS00622 LuxR-type HTH domain signature. 174 201 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 SMART SM00421 157 214 3.8E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 Gene3D G3DSA:1.10.10.10 128 222 1.1E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 Pfam PF00196 Bacterial regulatory proteins, luxR family 160 214 3.1E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22530 5cd2e1e5f1be1830e43387cb4cfea696 225 Gene3D G3DSA:3.40.50.2300 2 127 1.8E-38 T 17-03-2017 SHXM_RS01095 9afa31dba9652211a5adb3dfb96227da 255 SUPERFAMILY SSF46689 28 93 1.65E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01095 9afa31dba9652211a5adb3dfb96227da 255 SUPERFAMILY SSF48498 103 253 2.0E-29 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS01095 9afa31dba9652211a5adb3dfb96227da 255 Gene3D G3DSA:1.10.357.10 28 253 1.4E-60 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS01095 9afa31dba9652211a5adb3dfb96227da 255 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 99 249 4.0E-19 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS01095 9afa31dba9652211a5adb3dfb96227da 255 Pfam PF00440 Bacterial regulatory proteins, tetR family 42 84 1.3E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03405 6f8cb7146a4aaf7903ea547e3b82ea49 343 SUPERFAMILY SSF53850 37 282 2.42E-31 T 17-03-2017 SHXM_RS03405 6f8cb7146a4aaf7903ea547e3b82ea49 343 Pfam PF09084 NMT1/THI5 like 52 266 8.7E-21 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS03405 6f8cb7146a4aaf7903ea547e3b82ea49 343 Gene3D G3DSA:3.40.190.10 130 255 1.8E-12 T 17-03-2017 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 SUPERFAMILY SSF88713 7 226 5.56E-44 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 372 906 2.2E-10 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 Gene3D G3DSA:3.20.110.10 6 183 7.2E-38 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 SMART SM00872 276 345 0.0022 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 Gene3D G3DSA:1.20.1270.50 275 362 1.3E-5 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 SUPERFAMILY SSF74650 370 416 1.32E-29 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 SUPERFAMILY SSF74650 495 908 1.32E-29 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 6 250 3.8E-34 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS48725 37b036692a8e145fc7763cc3b6b5f90d 909 SUPERFAMILY SSF88688 275 362 1.34E-5 T 17-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 Pfam PF00931 NB-ARC domain 163 391 3.6E-9 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 SUPERFAMILY SSF48452 605 773 1.19E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 Gene3D G3DSA:1.25.40.10 560 796 8.7E-16 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 PRINTS PR00364 Disease resistance protein signature 247 261 2.4E-9 T 17-03-2017 SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 PRINTS PR00364 Disease resistance protein signature 163 178 2.4E-9 T 17-03-2017 SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 PRINTS PR00364 Disease resistance protein signature 334 348 2.4E-9 T 17-03-2017 SHXM_RS40840 eab45d719995a6ac953a52c721b648fc 815 SUPERFAMILY SSF52540 130 395 2.03E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40380 fc18f58801d2e9422cb214098eb34565 279 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 90 269 6.9E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40380 fc18f58801d2e9422cb214098eb34565 279 SUPERFAMILY SSF161098 5 279 3.74E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40380 fc18f58801d2e9422cb214098eb34565 279 Gene3D G3DSA:1.10.3720.10 4 266 2.5E-64 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45145 2ce196897694bc750879768602ebf078 134 SMART SM00960 8 98 3.9E-28 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS45145 2ce196897694bc750879768602ebf078 134 Gene3D G3DSA:3.30.450.30 6 123 1.0E-26 T 17-03-2017 SHXM_RS45145 2ce196897694bc750879768602ebf078 134 SUPERFAMILY SSF103196 6 127 4.36E-34 T 17-03-2017 SHXM_RS45145 2ce196897694bc750879768602ebf078 134 Pfam PF03259 Roadblock/LC7 domain 7 98 1.4E-26 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Pfam PF00072 Response regulator receiver domain 1732 1843 1.9E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF47384 1342 1426 5.1E-21 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF58104 516 647 2.44E-11 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Gene3D G3DSA:3.40.50.2300 1729 1850 2.2E-39 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1564 1582 1.7E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1588 1601 1.7E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1529 1543 1.7E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 PRINTS PR00344 Bacterial sensor protein C-terminal signature 1547 1557 1.7E-16 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Pfam PF00512 His Kinase A (phospho-acceptor) domain 1357 1424 4.4E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF58104 700 880 3.4E-15 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00448 1730 1844 1.3E-35 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF58104 332 465 1.28E-10 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 1048 1100 4.4E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 26 78 0.18 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 496 548 5.0E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 588 640 5.6E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 772 824 2.3E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 404 456 1.3E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 956 1008 7.2E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 864 916 1.7E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 680 732 6.2E-11 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 312 364 1.1E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 118 180 0.0047 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00304 220 272 5.5E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Pfam PF13185 GAF domain 1123 1269 4.3E-16 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Gene3D G3DSA:3.30.450.40 1107 1271 1.4E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Gene3D G3DSA:1.10.287.130 1347 1409 3.7E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF58104 884 975 8.11E-5 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Gene3D G3DSA:3.30.565.10 1410 1605 3.0E-44 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF55874 1413 1606 5.37E-45 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00388 1356 1424 1.2E-23 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00065 1124 1281 1.0E-7 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF58104 976 1098 1.52E-9 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF58104 156 328 1.96E-8 T 17-03-2017 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 1471 1603 4.2E-27 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Pfam PF00672 HAMP domain 309 360 6.5E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 Pfam PF00672 HAMP domain 678 728 2.2E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SMART SM00387 1471 1604 6.7E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF52172 1723 1848 3.98E-36 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS37150 c886618eed4136eea4e36fa96fedf510 1851 SUPERFAMILY SSF55781 1088 1271 2.7E-25 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS10655 fd778889d34c799a162c58a9c0aa6569 263 Gene3D G3DSA:1.10.12.10 201 257 3.5E-14 T 17-03-2017 IPR014748 Crontonase, C-terminal SHXM_RS10655 fd778889d34c799a162c58a9c0aa6569 263 SUPERFAMILY SSF52096 4 257 2.59E-69 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS10655 fd778889d34c799a162c58a9c0aa6569 263 Pfam PF00378 Enoyl-CoA hydratase/isomerase 6 257 3.7E-50 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS10655 fd778889d34c799a162c58a9c0aa6569 263 Gene3D G3DSA:3.90.226.10 3 199 1.2E-52 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS07575 9262779e0ede0083810d4a6a63cd3240 163 Gene3D G3DSA:1.10.10.10 26 154 5.4E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07575 9262779e0ede0083810d4a6a63cd3240 163 SUPERFAMILY SSF46785 20 158 3.6E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 SUPERFAMILY SSF52467 13 244 6.54E-71 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 Gene3D G3DSA:3.30.1600.10 27 66 3.8E-23 T 17-03-2017 IPR026591 Sirtuin family, catalytic core small domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 Gene3D G3DSA:3.30.1600.10 118 166 3.8E-23 T 17-03-2017 IPR026591 Sirtuin family, catalytic core small domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 Gene3D G3DSA:3.40.50.1220 172 244 3.3E-40 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 Gene3D G3DSA:3.40.50.1220 78 117 3.3E-40 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 Gene3D G3DSA:3.40.50.1220 13 26 3.3E-40 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS14795 f36ecdf848e3dc4479a2a4dafcbd2e94 247 Pfam PF02146 Sir2 family 16 196 1.5E-45 T 17-03-2017 IPR003000 Sirtuin family GO:0070403 SHXM_RS18205 39a8e32127fd46b7405ef70c02412456 522 Gene3D G3DSA:3.50.50.60 112 256 3.5E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18205 39a8e32127fd46b7405ef70c02412456 522 SUPERFAMILY SSF51905 32 310 1.94E-14 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18205 39a8e32127fd46b7405ef70c02412456 522 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 32 390 6.9E-104 T 17-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase SHXM_RS10340 e9fa417a3a3772d33a4eebaa02a79f9d 223 Pfam PF07510 Protein of unknown function (DUF1524) 114 195 2.1E-5 T 17-03-2017 IPR011089 Domain of unknown function DUF1524 SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 Gene3D G3DSA:3.90.550.10 4 262 8.3E-72 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 Hamap MF_01631 Bifunctional protein GlmU [glmU]. 6 463 40.355 T 17-03-2017 IPR005882 Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase GO:0000287|GO:0000902|GO:0003977|GO:0005737|GO:0009103|GO:0009252|GO:0019134 KEGG: 00520+2.3.1.157+2.7.7.23|KEGG: 00561+2.3.1.15|KEGG: 00564+2.3.1.15|MetaCyc: PWY-5514|MetaCyc: PWY-5667|MetaCyc: PWY-6453|MetaCyc: PWY-7411|MetaCyc: PWY-7587 SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 Gene3D G3DSA:2.160.10.10 268 449 1.3E-42 T 17-03-2017 SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 SUPERFAMILY SSF51161 260 478 5.0E-45 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 405 440 6.4E-7 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 SUPERFAMILY SSF53448 8 264 8.97E-60 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 TIGRFAM TIGR01173 glmU: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase 8 465 9.3E-164 T 17-03-2017 IPR005882 Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase GO:0000287|GO:0000902|GO:0003977|GO:0005737|GO:0009103|GO:0009252|GO:0019134 KEGG: 00520+2.3.1.157+2.7.7.23|KEGG: 00561+2.3.1.15|KEGG: 00564+2.3.1.15|MetaCyc: PWY-5514|MetaCyc: PWY-5667|MetaCyc: PWY-6453|MetaCyc: PWY-7411|MetaCyc: PWY-7587 SHXM_RS32805 11d9bdff901573fe21bba48308ea5f6c 485 Pfam PF12804 MobA-like NTP transferase domain 9 142 9.2E-20 T 17-03-2017 IPR025877 MobA-like NTP transferase SHXM_RS04855 efb7267a63088e2addd57c1c2157a4d9 144 SUPERFAMILY SSF50685 62 143 9.0E-8 T 17-03-2017 IPR009009 RlpA-like protein, double-psi beta-barrel domain SHXM_RS04855 efb7267a63088e2addd57c1c2157a4d9 144 Pfam PF03330 Lytic transglycolase 52 138 1.0E-8 T 17-03-2017 IPR009009 RlpA-like protein, double-psi beta-barrel domain SHXM_RS04855 efb7267a63088e2addd57c1c2157a4d9 144 Gene3D G3DSA:2.40.40.10 38 41 1.2E-5 T 17-03-2017 IPR009009 RlpA-like protein, double-psi beta-barrel domain SHXM_RS04855 efb7267a63088e2addd57c1c2157a4d9 144 Gene3D G3DSA:2.40.40.10 81 143 1.2E-5 T 17-03-2017 IPR009009 RlpA-like protein, double-psi beta-barrel domain SHXM_RS43260 0647c00fb00259492b7877332f1f5a1a 228 Pfam PF13581 Histidine kinase-like ATPase domain 4 118 4.9E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43260 0647c00fb00259492b7877332f1f5a1a 228 SUPERFAMILY SSF55874 34 124 3.28E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS48605 0ab3c5545e8d72c52fac144da6085d30 478 SUPERFAMILY SSF89000 302 419 5.1E-7 T 17-03-2017 SHXM_RS48605 0ab3c5545e8d72c52fac144da6085d30 478 SUPERFAMILY SSF51569 4 303 4.83E-31 T 17-03-2017 SHXM_RS48605 0ab3c5545e8d72c52fac144da6085d30 478 Pfam PF02436 Conserved carboxylase domain 298 395 5.7E-6 T 17-03-2017 IPR003379 Carboxylase, conserved domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599|Reactome: R-HSA-70263 SHXM_RS48605 0ab3c5545e8d72c52fac144da6085d30 478 Pfam PF00682 HMGL-like 129 259 3.3E-9 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS48605 0ab3c5545e8d72c52fac144da6085d30 478 Gene3D G3DSA:3.20.20.70 5 280 1.2E-30 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS40830 a49ef1e55a584335ca6efb0a97ffb0f7 276 Gene3D G3DSA:3.40.50.720 115 237 9.2E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40830 a49ef1e55a584335ca6efb0a97ffb0f7 276 SUPERFAMILY SSF51735 114 237 9.91E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40830 a49ef1e55a584335ca6efb0a97ffb0f7 276 Pfam PF00106 short chain dehydrogenase 115 174 2.6E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40830 a49ef1e55a584335ca6efb0a97ffb0f7 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 137 156 9.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40830 a49ef1e55a584335ca6efb0a97ffb0f7 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 111 127 9.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40830 a49ef1e55a584335ca6efb0a97ffb0f7 276 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 175 9.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Pfam PF02896 PEP-utilising enzyme, TIM barrel domain 548 901 2.5E-86 T 17-03-2017 IPR000121 PEP-utilising enzyme, C-terminal GO:0016310|GO:0016772 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:1.10.189.10 346 408 2.0E-23 T 17-03-2017 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:3.30.1490.20 9 115 2.1E-57 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:3.30.1490.20 204 247 2.1E-57 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:1.20.80.30 116 202 4.0E-34 T 17-03-2017 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 SUPERFAMILY SSF51621 550 903 4.28E-114 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Pfam PF00391 PEP-utilising enzyme, mobile domain 428 515 4.9E-25 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 SUPERFAMILY SSF52009 398 524 1.83E-32 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 301 355 2.2E-9 T 17-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Pfam PF01326 Pyruvate phosphate dikinase, PEP/pyruvate binding domain 23 291 8.4E-42 T 17-03-2017 IPR002192 Pyruvate phosphate dikinase, PEP/pyruvate-binding GO:0005524|GO:0016301|GO:0016310 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:3.30.470.20 248 345 5.8E-34 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 ProSitePatterns PS00370 PEP-utilizing enzymes phosphorylation site signature. 456 467 - T 17-03-2017 IPR018274 PEP-utilising enzyme, active site GO:0016310|GO:0016772 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 PIRSF PIRSF000853 7 908 0.0 T 17-03-2017 IPR010121 Pyruvate, phosphate dikinase GO:0006090|GO:0050242 KEGG: 00620+2.7.9.1|KEGG: 00710+2.7.9.1|KEGG: 00720+2.7.9.1|MetaCyc: PWY-241|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 TIGRFAM TIGR01828 pyru_phos_dikin: pyruvate, phosphate dikinase 8 904 0.0 T 17-03-2017 IPR010121 Pyruvate, phosphate dikinase GO:0006090|GO:0050242 KEGG: 00620+2.7.9.1|KEGG: 00710+2.7.9.1|KEGG: 00720+2.7.9.1|MetaCyc: PWY-241|MetaCyc: PWY-6549|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:3.20.20.60 562 905 2.6E-129 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 SUPERFAMILY SSF56059 7 381 4.47E-133 T 17-03-2017 SHXM_RS20945 a9f32aed1fb2103b2fbc495399b4d885 908 Gene3D G3DSA:3.50.30.10 409 518 2.3E-36 T 17-03-2017 IPR008279 PEP-utilising enzyme, mobile domain GO:0016310|GO:0016772 SHXM_RS13910 6e229c980c40904a751f8dfe8f1df708 340 Gene3D G3DSA:3.30.420.40 1 121 4.1E-32 T 17-03-2017 SHXM_RS13910 6e229c980c40904a751f8dfe8f1df708 340 Pfam PF02541 Ppx/GppA phosphatase family 17 304 2.8E-60 T 17-03-2017 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40 SHXM_RS13910 6e229c980c40904a751f8dfe8f1df708 340 SUPERFAMILY SSF53067 129 306 3.17E-31 T 17-03-2017 SHXM_RS13910 6e229c980c40904a751f8dfe8f1df708 340 SUPERFAMILY SSF53067 3 125 3.32E-27 T 17-03-2017 SHXM_RS13910 6e229c980c40904a751f8dfe8f1df708 340 Gene3D G3DSA:3.30.420.150 124 305 5.5E-41 T 17-03-2017 SHXM_RS04155 024303687dc57e34f6523fe0fb8d0196 406 TIGRFAM TIGR00236 wecB: UDP-N-acetylglucosamine 2-epimerase 26 382 5.3E-133 T 17-03-2017 IPR029767 UDP-N-acetylglucosamine 2-epimerase WecB-like GO:0008761 KEGG: 00520+5.1.3.14|MetaCyc: PWY-7335 SHXM_RS04155 024303687dc57e34f6523fe0fb8d0196 406 Pfam PF02350 UDP-N-acetylglucosamine 2-epimerase 46 381 2.4E-111 T 17-03-2017 IPR003331 UDP-N-acetylglucosamine 2-epimerase domain Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS04155 024303687dc57e34f6523fe0fb8d0196 406 Gene3D G3DSA:3.40.50.2000 224 382 9.9E-54 T 17-03-2017 SHXM_RS04155 024303687dc57e34f6523fe0fb8d0196 406 SUPERFAMILY SSF53756 26 383 1.48E-117 T 17-03-2017 SHXM_RS04155 024303687dc57e34f6523fe0fb8d0196 406 Gene3D G3DSA:3.40.50.2000 25 223 4.9E-73 T 17-03-2017 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 SUPERFAMILY SSF54427 203 319 2.43E-21 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 SUPERFAMILY SSF88659 132 190 9.72E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 TIGRFAM TIGR02960 SigX5: RNA polymerase sigma-70 factor, TIGR02960 family 13 323 2.9E-131 T 17-03-2017 IPR014305 RNA polymerase sigma-G type, actinobacteria SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 SUPERFAMILY SSF88946 16 92 5.1E-23 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 18 189 2.1E-25 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 Gene3D G3DSA:1.10.1740.10 17 102 2.7E-26 T 17-03-2017 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 Pfam PF12680 SnoaL-like domain 212 306 7.6E-8 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 Pfam PF04542 Sigma-70 region 2 18 83 6.3E-21 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 Gene3D G3DSA:1.10.10.10 133 191 1.2E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 Pfam PF08281 Sigma-70, region 4 136 189 8.0E-14 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS06970 810fa0cad7947695fc0ff8f650678eb7 333 Gene3D G3DSA:3.10.450.50 204 321 3.4E-23 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 SUPERFAMILY SSF50998 593 688 1.77E-9 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 132 144 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 Gene3D G3DSA:2.140.10.10 384 698 8.0E-23 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 20 42 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 SUPERFAMILY SSF56112 11 263 3.64E-59 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 Pfam PF13360 PQQ-like domain 406 562 1.9E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 Pfam PF13360 PQQ-like domain 603 691 1.2E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 SMART SM00220 14 266 7.2E-41 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 SUPERFAMILY SSF50998 377 513 3.3E-7 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 Gene3D G3DSA:1.10.510.10 69 273 6.9E-40 T 17-03-2017 SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 Gene3D G3DSA:3.30.200.20 8 68 9.4E-14 T 17-03-2017 SHXM_RS30345 ce6ca44646ff75b75f7210adaa6169be 721 Pfam PF00069 Protein kinase domain 14 261 1.0E-37 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS48955 3c2360df0ef4c4e936e282167e2845fd 424 SUPERFAMILY SSF103473 33 422 8.24E-48 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS48955 3c2360df0ef4c4e936e282167e2845fd 424 Gene3D G3DSA:1.20.1250.20 36 215 1.5E-14 T 17-03-2017 SHXM_RS48955 3c2360df0ef4c4e936e282167e2845fd 424 Gene3D G3DSA:1.20.1250.20 227 411 2.4E-17 T 17-03-2017 SHXM_RS48955 3c2360df0ef4c4e936e282167e2845fd 424 Pfam PF07690 Major Facilitator Superfamily 51 375 1.5E-19 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS16620 51c571ce880b2990d4efcc83de0afdc5 111 SMART SM00530 40 95 3.0E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS16620 51c571ce880b2990d4efcc83de0afdc5 111 Gene3D G3DSA:1.10.260.40 30 101 6.0E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS16620 51c571ce880b2990d4efcc83de0afdc5 111 SUPERFAMILY SSF47413 27 100 6.48E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS16620 51c571ce880b2990d4efcc83de0afdc5 111 Pfam PF13560 Helix-turn-helix domain 37 91 1.1E-9 T 17-03-2017 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 359 462 1.2E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 Gene3D G3DSA:3.30.565.10 322 462 3.1E-26 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 409 419 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 391 405 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 424 442 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 PRINTS PR00344 Bacterial sensor protein C-terminal signature 448 461 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 SMART SM00387 356 463 5.9E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 SUPERFAMILY SSF47384 231 311 3.73E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 Pfam PF00512 His Kinase A (phospho-acceptor) domain 249 312 2.2E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 SUPERFAMILY SSF55874 322 462 1.69E-26 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 Gene3D G3DSA:1.10.287.130 239 306 1.3E-8 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45935 485b1f7ffee3b351e68a7bc665769afa 463 SMART SM00388 247 313 2.5E-7 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS05435 7449ce759d05686da5444a404b2dae27 291 Gene3D G3DSA:1.10.3720.10 15 278 4.8E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05435 7449ce759d05686da5444a404b2dae27 291 SUPERFAMILY SSF161098 17 291 5.14E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05435 7449ce759d05686da5444a404b2dae27 291 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 283 7.1E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15910 fe8880210711742c46577ba54c272c3e 257 Pfam PF00227 Proteasome subunit 25 207 7.6E-29 T 17-03-2017 IPR001353 Proteasome, subunit alpha/beta GO:0004298|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 SHXM_RS15910 fe8880210711742c46577ba54c272c3e 257 Gene3D G3DSA:3.60.20.10 3 238 5.2E-86 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS15910 fe8880210711742c46577ba54c272c3e 257 Hamap MF_00289_B Proteasome subunit alpha [prcA]. 1 234 49.795 T 17-03-2017 IPR022296 Proteasome, alpha subunit, bacterial GO:0004298|GO:0019773|GO:0051603 SHXM_RS15910 fe8880210711742c46577ba54c272c3e 257 SUPERFAMILY SSF56235 10 229 7.73E-45 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS15910 fe8880210711742c46577ba54c272c3e 257 TIGRFAM TIGR03691 20S_bact_alpha: proteasome, alpha subunit 2 230 1.5E-117 T 17-03-2017 IPR022296 Proteasome, alpha subunit, bacterial GO:0004298|GO:0019773|GO:0051603 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 PRINTS PR00834 HtrA/DegQ protease family signature 228 240 3.4E-8 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 PRINTS PR00834 HtrA/DegQ protease family signature 329 346 3.4E-8 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 PRINTS PR00834 HtrA/DegQ protease family signature 250 270 3.4E-8 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 Gene3D G3DSA:2.40.10.10 291 385 8.7E-14 T 17-03-2017 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 Pfam PF02674 Colicin V production protein 4 144 1.6E-18 T 17-03-2017 IPR003825 Colicin V production, CvpA GO:0009403|GO:0016020 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 Pfam PF13365 Trypsin-like peptidase domain 220 358 2.9E-21 T 17-03-2017 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 Gene3D G3DSA:2.40.10.10 219 290 5.3E-15 T 17-03-2017 SHXM_RS26985 a5305b648dfeee31c33a9c309e3403a5 399 SUPERFAMILY SSF50494 196 384 2.52E-35 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS34085 79bcc7cef261624be0fee39504a5603d 268 Gene3D G3DSA:3.90.226.10 3 266 1.0E-74 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS34085 79bcc7cef261624be0fee39504a5603d 268 Pfam PF00378 Enoyl-CoA hydratase/isomerase 11 267 4.5E-58 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS34085 79bcc7cef261624be0fee39504a5603d 268 SUPERFAMILY SSF52096 2 268 1.66E-76 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 Gene3D G3DSA:3.30.565.10 334 501 8.1E-38 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 Gene3D G3DSA:1.10.287.130 274 333 1.2E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 SMART SM00387 390 499 3.6E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 SMART SM00388 282 347 4.7E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 SMART SM00304 228 281 0.0021 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 Pfam PF00512 His Kinase A (phospho-acceptor) domain 283 346 1.0E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 425 439 2.0E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 443 453 2.0E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 460 478 2.0E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 PRINTS PR00344 Bacterial sensor protein C-terminal signature 483 496 2.0E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 SUPERFAMILY SSF47384 265 346 7.26E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 SUPERFAMILY SSF55874 336 500 5.37E-38 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 Pfam PF00672 HAMP domain 209 277 6.9E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS26105 a2f33cef821bdbf1424cfaa991dd87b4 504 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 392 497 5.5E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 Gene3D G3DSA:3.30.390.10 36 94 3.8E-13 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 Gene3D G3DSA:3.20.20.120 95 317 6.7E-69 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 TIGRFAM TIGR01928 menC_lowGC/arch: o-succinylbenzoate synthase 53 298 1.9E-73 T 17-03-2017 IPR010197 o-succinylbenzoate synthase, MenC type 2 GO:0009234|GO:0016829 KEGG: 00010+4.2.1.11|KEGG: 00130+4.2.1.113|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-5837|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 SUPERFAMILY SSF51604 90 326 3.01E-66 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 SUPERFAMILY SSF54826 36 91 4.28E-6 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 Hamap MF_01933 o-succinylbenzoate synthase [menC]. 8 326 33.565 T 17-03-2017 IPR010197 o-succinylbenzoate synthase, MenC type 2 GO:0009234|GO:0016829 KEGG: 00010+4.2.1.11|KEGG: 00130+4.2.1.113|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-5837|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 Pfam PF13378 Enolase C-terminal domain-like 112 320 2.4E-46 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS48055 6b2df6edf0263096008b40a09d2a4b1b 340 SMART SM00922 109 202 6.3E-19 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS36910 a80b0738251f854f9b83d0246f8a55e4 174 Pfam PF02576 Putative ribosome maturation factor RimP 12 151 8.2E-34 T 17-03-2017 IPR003728 Ribosome maturation factor RimP GO:0042274 SHXM_RS36910 a80b0738251f854f9b83d0246f8a55e4 174 Gene3D G3DSA:3.30.300.70 3 82 1.2E-23 T 17-03-2017 IPR028989 Ribosome maturation factor RimP, N-terminal SHXM_RS36910 a80b0738251f854f9b83d0246f8a55e4 174 Hamap MF_01077 Ribosome maturation factor RimP [rimP]. 7 155 22.894 T 17-03-2017 IPR003728 Ribosome maturation factor RimP GO:0042274 SHXM_RS36910 a80b0738251f854f9b83d0246f8a55e4 174 SUPERFAMILY SSF75420 3 85 3.27E-19 T 17-03-2017 IPR028989 Ribosome maturation factor RimP, N-terminal SHXM_RS18805 f0b09d006ee3bc1ba239e735f7f965d5 146 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 11 139 2.5E-13 T 17-03-2017 IPR005031 Coenzyme Q-binding protein COQ10, START domain SHXM_RS18805 f0b09d006ee3bc1ba239e735f7f965d5 146 SUPERFAMILY SSF55961 1 145 6.02E-30 T 17-03-2017 SHXM_RS18805 f0b09d006ee3bc1ba239e735f7f965d5 146 Gene3D G3DSA:3.30.530.20 4 145 4.8E-18 T 17-03-2017 IPR023393 START-like domain SHXM_RS45985 bba8e193bdffc9aeef08199cbd01db90 454 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 261 297 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS45985 bba8e193bdffc9aeef08199cbd01db90 454 Gene3D G3DSA:3.40.640.10 82 326 2.8E-59 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS45985 bba8e193bdffc9aeef08199cbd01db90 454 Pfam PF00202 Aminotransferase class-III 44 443 7.3E-85 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS45985 bba8e193bdffc9aeef08199cbd01db90 454 TIGRFAM TIGR00709 dat: 2,4-diaminobutyrate 4-transaminase 28 445 2.9E-126 T 17-03-2017 IPR004637 2,4-diaminobutyrate 4-transaminase GO:0008483|GO:0009058 KEGG: 00260+2.6.1.76|MetaCyc: PWY-6409|MetaCyc: PWY-6562|MetaCyc: PWY-761 SHXM_RS45985 bba8e193bdffc9aeef08199cbd01db90 454 SUPERFAMILY SSF53383 30 444 1.15E-104 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS45985 bba8e193bdffc9aeef08199cbd01db90 454 Gene3D G3DSA:3.90.1150.10 327 446 9.4E-42 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 Pfam PF00392 Bacterial regulatory proteins, gntR family 10 71 6.7E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 SUPERFAMILY SSF48008 77 216 4.71E-15 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 SUPERFAMILY SSF46785 3 81 3.08E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 SMART SM00345 13 71 6.4E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 Pfam PF07729 FCD domain 81 209 6.2E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 Gene3D G3DSA:1.20.120.530 75 217 3.1E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 SMART SM00895 81 210 2.1E-11 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS39710 da3992660350e1fe3659c30ce8b5e4c4 235 Gene3D G3DSA:1.10.10.10 5 71 7.4E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 SUPERFAMILY SSF52440 11 123 4.1E-44 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 Gene3D G3DSA:3.30.1490.20 140 211 6.1E-32 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 TIGRFAM TIGR00514 accC: acetyl-CoA carboxylase, biotin carboxylase subunit 13 453 1.2E-190 T 17-03-2017 IPR004549 Acetyl-CoA carboxylase, biotin carboxylase GO:0016874 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 ProSitePatterns PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 296 303 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 SUPERFAMILY SSF56059 93 358 1.17E-74 T 17-03-2017 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 Pfam PF00289 Biotin carboxylase, N-terminal domain 12 120 2.4E-41 T 17-03-2017 IPR005481 Biotin carboxylase-like, N-terminal domain Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 Pfam PF02785 Biotin carboxylase C-terminal domain 346 452 1.4E-40 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 125 332 1.1E-80 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 Gene3D G3DSA:3.40.50.20 12 139 3.0E-46 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 Gene3D G3DSA:3.30.470.20 212 455 1.4E-101 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 162 176 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 SMART SM00878 346 452 8.5E-61 T 17-03-2017 IPR005482 Biotin carboxylase, C-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS48610 9db756b8c94bcd4d2f1d842151ecc425 476 SUPERFAMILY SSF51246 341 454 1.83E-42 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS29900 973e71306915f5c40d068497c2c6690d 335 SUPERFAMILY SSF54001 195 321 1.62E-35 T 17-03-2017 SHXM_RS29900 973e71306915f5c40d068497c2c6690d 335 SUPERFAMILY SSF53955 46 189 3.7E-34 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS29900 973e71306915f5c40d068497c2c6690d 335 Gene3D G3DSA:1.10.530.10 49 193 4.8E-35 T 17-03-2017 SHXM_RS29900 973e71306915f5c40d068497c2c6690d 335 Pfam PF00877 NlpC/P60 family 212 306 7.7E-23 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS29900 973e71306915f5c40d068497c2c6690d 335 Pfam PF01464 Transglycosylase SLT domain 65 174 1.2E-15 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS29900 973e71306915f5c40d068497c2c6690d 335 Gene3D G3DSA:3.90.1720.10 194 322 1.4E-38 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS03805 22e360bb70d0ced36f9161bbeb28c2db 63 Pfam PF14404 Ribosomally synthesized peptide in Streptomyces species 1 63 2.3E-36 T 17-03-2017 IPR025744 Ribosomally synthesised peptide in Streptomyces SHXM_RS03805 22e360bb70d0ced36f9161bbeb28c2db 63 TIGRFAM TIGR04186 GRASP_targ: putative ATP-grasp target RiPP 1 63 9.3E-14 T 17-03-2017 IPR026496 Putative ATP-grasp target RiPP SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 Pfam PF07687 Peptidase dimerisation domain 205 333 2.6E-14 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 Gene3D G3DSA:3.30.70.360 295 340 5.1E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 Gene3D G3DSA:3.30.70.360 218 257 5.1E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 Pfam PF01546 Peptidase family M20/M25/M40 88 443 4.3E-37 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 SUPERFAMILY SSF53187 355 442 2.62E-54 T 17-03-2017 SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 SUPERFAMILY SSF53187 17 208 2.62E-54 T 17-03-2017 SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 SUPERFAMILY SSF55031 208 253 1.44E-9 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 SUPERFAMILY SSF55031 294 334 1.44E-9 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 Gene3D G3DSA:3.40.630.10 17 217 1.1E-60 T 17-03-2017 SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 Gene3D G3DSA:3.40.630.10 380 443 1.1E-60 T 17-03-2017 SHXM_RS16115 8d78b5ce8276507aa9baee9abf2f8313 445 ProSitePatterns PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 87 96 - T 17-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SHXM_RS03400 4af4fe445a495f1c6e8ca25e86798068 370 SUPERFAMILY SSF53756 87 357 3.14E-22 T 17-03-2017 SHXM_RS03400 4af4fe445a495f1c6e8ca25e86798068 370 Gene3D G3DSA:3.40.50.2000 175 335 9.8E-11 T 17-03-2017 SHXM_RS03400 4af4fe445a495f1c6e8ca25e86798068 370 Pfam PF06925 Monogalactosyldiacylglycerol (MGDG) synthase 22 167 1.1E-22 T 17-03-2017 IPR009695 Diacylglycerol glucosyltransferase, N-terminal GO:0009247|GO:0016758 SHXM_RS36255 d2d13b081242154ef9c65bfba440eed6 79 Pfam PF13822 Acyl-CoA carboxylase epsilon subunit 18 77 9.3E-16 T 17-03-2017 IPR032716 Acyl-CoA carboxylase epsilon subunit SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 SUPERFAMILY SSF51604 123 406 1.44E-62 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 31 135 4.0E-18 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 110 135 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 Pfam PF13378 Enolase C-terminal domain-like 163 399 1.5E-39 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 Gene3D G3DSA:3.30.390.10 22 140 7.9E-34 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 SMART SM00922 153 279 3.3E-16 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 SUPERFAMILY SSF54826 25 139 1.36E-24 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS42385 eee85b95655ced796103b3bcab6d7a9c 428 Gene3D G3DSA:3.20.20.120 141 393 3.0E-62 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 Pfam PF00480 ROK family 93 357 7.5E-31 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 SUPERFAMILY SSF53067 92 402 2.42E-35 T 17-03-2017 SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 Pfam PF12802 MarR family 23 75 1.5E-6 T 17-03-2017 SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 Gene3D G3DSA:3.30.420.40 227 378 3.2E-26 T 17-03-2017 SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 Gene3D G3DSA:3.30.420.40 88 226 6.8E-35 T 17-03-2017 SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 SUPERFAMILY SSF46785 20 83 1.37E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12175 0d4a4490f05186e37c42e532b08bed33 408 Gene3D G3DSA:1.10.10.10 18 83 1.4E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 Gene3D G3DSA:3.40.190.10 90 175 1.2E-14 T 17-03-2017 SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 Gene3D G3DSA:1.10.10.10 1 85 3.1E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 3.0E-16 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 Gene3D G3DSA:3.40.190.10 176 265 3.4E-9 T 17-03-2017 SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 SUPERFAMILY SSF46785 1 84 2.21E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 SUPERFAMILY SSF53850 89 292 8.83E-26 T 17-03-2017 SHXM_RS40420 bbffd6ad834347c87b5c08061c8526b2 306 Pfam PF03466 LysR substrate binding domain 87 288 3.0E-27 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF00698 Acyl transferase domain 2376 2698 2.6E-81 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF00698 Acyl transferase domain 567 890 2.6E-78 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF53901 1834 2210 1.47E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1468 1648 8.9E-47 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3605 3785 7.4E-50 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.47.10 297 462 4.9E-65 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.47.10 2102 2267 4.0E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF51735 1466 1672 1.1E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.50.720 1467 1680 4.4E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF55048 2500 2568 4.45E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00823 Phosphopantetheine attachment site 1747 1819 2.5E-30 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00823 Phosphopantetheine attachment site 3890 3962 1.6E-32 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF51735 3603 3807 3.92E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 568 871 6.4E-109 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2377 2680 9.9E-114 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.90.180.10 3304 3420 6.1E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF47336 1741 1853 1.02E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 197 213 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 36 284 1.5E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1838 2089 2.1E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 414 528 5.2E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 2217 2336 1.7E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.50.720 3421 3517 6.8E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:1.10.1200.10 1745 1820 6.9E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:1.10.1200.10 3887 3962 3.9E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 2002 2018 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM01294 3891 3958 9.6E-6 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM01294 1748 1815 7.9E-6 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3917 3932 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1774 1789 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00825 Beta-ketoacyl synthase 1840 2267 1.5E-225 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00825 Beta-ketoacyl synthase 38 462 3.9E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF00550 Phosphopantetheine attachment site 1749 1815 1.6E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF00550 Phosphopantetheine attachment site 3893 3957 8.4E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.47.10 38 296 3.0E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.47.10 1840 2101 6.0E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF47336 3883 3972 3.8E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF08990 Erythronolide synthase docking 5 29 3.2E-11 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF52151 566 693 3.92E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF52151 760 865 3.92E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF52151 2569 2674 3.92E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF52151 2375 2502 3.92E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.366.10 2375 2496 1.6E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.366.10 2568 2680 1.6E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.30.70.250 2500 2567 3.4E-8 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.30.70.250 691 758 2.2E-7 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF55048 691 759 5.1E-10 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 3309 3364 1.6E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.366.10 566 687 3.0E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.366.10 759 873 3.0E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF50129 3281 3425 7.7E-26 T 17-03-2017 IPR011032 GroES-like SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF101173 4 36 9.15E-5 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00826 2749 2916 6.6E-76 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00826 939 1107 8.0E-70 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Gene3D G3DSA:3.40.50.720 3605 3802 1.0E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF53901 33 399 7.89E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF14765 Polyketide synthase dehydratase 939 1230 1.6E-48 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF14765 Polyketide synthase dehydratase 2749 3047 8.7E-48 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF13602 Zinc-binding dehydrogenase 3462 3595 2.6E-19 T 17-03-2017 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 2097 2214 1.5E-44 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 4.2E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF51735 3057 3206 1.71E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF51735 3246 3264 1.71E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF08659 KR domain 3605 3784 1.3E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 Pfam PF08659 KR domain 1468 1646 4.2E-54 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF51735 3388 3566 2.99E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SUPERFAMILY SSF51735 1239 1446 3.5E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06440 21318932ce2ba9d24da8381688dd6853 4047 SMART SM00829 3289 3595 2.4E-183 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS10075 3e71e655388ae8f8b79a1df6d16d242f 934 Pfam PF01476 LysM domain 187 242 2.0E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS10075 3e71e655388ae8f8b79a1df6d16d242f 934 SUPERFAMILY SSF48452 762 908 1.85E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10075 3e71e655388ae8f8b79a1df6d16d242f 934 Pfam PF03704 Bacterial transcriptional activator domain 759 898 9.4E-15 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS10075 3e71e655388ae8f8b79a1df6d16d242f 934 Gene3D G3DSA:3.10.350.10 186 242 1.4E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS10075 3e71e655388ae8f8b79a1df6d16d242f 934 SMART SM01043 759 902 6.9E-22 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS10995 c8ed5666ce613f0db6e690b8c28e3f6c 461 Gene3D G3DSA:1.20.1250.20 234 442 3.5E-17 T 17-03-2017 SHXM_RS10995 c8ed5666ce613f0db6e690b8c28e3f6c 461 Gene3D G3DSA:1.20.1250.20 15 199 5.2E-14 T 17-03-2017 SHXM_RS10995 c8ed5666ce613f0db6e690b8c28e3f6c 461 SUPERFAMILY SSF103473 14 438 3.4E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS10995 c8ed5666ce613f0db6e690b8c28e3f6c 461 Pfam PF07690 Major Facilitator Superfamily 30 387 4.5E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 SUPERFAMILY SSF50370 751 873 8.1E-37 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Pfam PF00652 Ricin-type beta-trefoil lectin domain 619 743 9.5E-30 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Pfam PF00652 Ricin-type beta-trefoil lectin domain 753 872 3.5E-25 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 SUPERFAMILY SSF51445 282 476 1.22E-18 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 SUPERFAMILY SSF50370 620 744 2.23E-39 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Gene3D G3DSA:2.80.10.50 613 744 6.3E-42 T 17-03-2017 SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Gene3D G3DSA:2.80.10.50 754 873 4.8E-36 T 17-03-2017 SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 SMART SM00458 617 746 1.2E-30 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 SMART SM00458 748 875 5.8E-28 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Pfam PF10566 Glycoside hydrolase 97 282 512 2.1E-63 T 17-03-2017 IPR019563 Glycosyl-hydrolase 97, catalytic domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Pfam PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation 514 603 2.8E-18 T 17-03-2017 IPR029483 Glycosyl-hydrolase 97, C-terminal oligomerisation domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Pfam PF14508 Glycosyl-hydrolase 97 N-terminal 55 277 5.2E-39 T 17-03-2017 IPR029486 Glycosyl-hydrolase 97, N-terminal domain SHXM_RS38895 bfa1bc5350915339c7867b8188e2c5e2 876 Gene3D G3DSA:3.20.20.70 292 423 3.3E-7 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS23400 161e5f3e37696ea9cbe08e67967fcc25 250 SUPERFAMILY SSF56281 1 249 5.9E-54 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23400 161e5f3e37696ea9cbe08e67967fcc25 250 Pfam PF12706 Beta-lactamase superfamily domain 30 218 4.8E-21 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23400 161e5f3e37696ea9cbe08e67967fcc25 250 SMART SM00849 18 199 6.9E-9 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23400 161e5f3e37696ea9cbe08e67967fcc25 250 Gene3D G3DSA:3.60.15.10 1 249 5.0E-60 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS16765 46ba9cfef18a4b5246c502acfe64f22c 221 SUPERFAMILY SSF46689 8 79 1.85E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16765 46ba9cfef18a4b5246c502acfe64f22c 221 Gene3D G3DSA:1.10.357.10 4 161 2.3E-18 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS16765 46ba9cfef18a4b5246c502acfe64f22c 221 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 65 2.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 SUPERFAMILY SSF50494 175 390 3.38E-56 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 SMART SM00228 417 477 3.5E-4 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 Pfam PF13365 Trypsin-like peptidase domain 202 348 4.6E-33 T 17-03-2017 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 Gene3D G3DSA:2.40.10.10 167 271 6.5E-26 T 17-03-2017 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 Gene3D G3DSA:2.40.10.10 272 399 1.6E-40 T 17-03-2017 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 Pfam PF13180 PDZ domain 399 486 6.4E-23 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 SUPERFAMILY SSF50156 378 485 3.68E-17 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 PRINTS PR00834 HtrA/DegQ protease family signature 235 255 1.0E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 PRINTS PR00834 HtrA/DegQ protease family signature 211 223 1.0E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 PRINTS PR00834 HtrA/DegQ protease family signature 341 358 1.0E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 PRINTS PR00834 HtrA/DegQ protease family signature 435 447 1.0E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 PRINTS PR00834 HtrA/DegQ protease family signature 319 336 1.0E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 PRINTS PR00834 HtrA/DegQ protease family signature 278 302 1.0E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS27600 f84f46fe6b02599acb4a26804ca6cf21 493 Gene3D G3DSA:2.30.42.10 424 491 1.0E-17 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 Gene3D G3DSA:1.10.10.10 1 83 7.8E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 SUPERFAMILY SSF46785 1 109 2.03E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 Gene3D G3DSA:3.40.190.10 87 220 1.1E-15 T 17-03-2017 SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 Gene3D G3DSA:3.40.190.10 221 264 9.5E-9 T 17-03-2017 SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 Pfam PF03466 LysR substrate binding domain 87 293 8.4E-23 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 SUPERFAMILY SSF53850 87 297 1.23E-22 T 17-03-2017 SHXM_RS01860 9f77073f7f86e3970db49b650cc0d7fe 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 2.3E-13 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 SMART SM00829 49 416 6.1E-10 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 SUPERFAMILY SSF50129 44 230 4.72E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 TIGRFAM TIGR01751 crot-CoA-red: crotonyl-CoA carboxylase/reductase 32 429 3.7E-173 T 17-03-2017 IPR010085 Crotonyl-CoA reductase GO:0043880 KEGG: 00650+1.3.1.86 SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 Gene3D G3DSA:3.40.50.720 233 365 9.3E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 Gene3D G3DSA:3.90.180.10 45 232 5.3E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 111 191 3.6E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 Pfam PF00107 Zinc-binding dehydrogenase 237 381 1.3E-32 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS07165 836861cf7d5985e9518739eda874d901 447 SUPERFAMILY SSF51735 196 386 7.93E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43515 a4714032bf606e97813d5ffa37a6255d 293 SUPERFAMILY SSF52540 46 234 2.72E-30 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43515 a4714032bf606e97813d5ffa37a6255d 293 Gene3D G3DSA:3.40.50.300 14 250 1.0E-105 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43515 a4714032bf606e97813d5ffa37a6255d 293 Pfam PF03976 Polyphosphate kinase 2 (PPK2) 17 239 4.2E-107 T 17-03-2017 IPR022488 Polyphosphate kinase-2-related SHXM_RS43515 a4714032bf606e97813d5ffa37a6255d 293 TIGRFAM TIGR03707 PPK2_P_aer: polyphosphate kinase 2 16 239 1.7E-115 T 17-03-2017 IPR022486 Polyphosphate kinase 2, PA0141 GO:0006793|GO:0008976 SHXM_RS43515 a4714032bf606e97813d5ffa37a6255d 293 PIRSF PIRSF028756 1 270 4.2E-126 T 17-03-2017 IPR016898 Polyphosphate kinase 2 SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 Gene3D G3DSA:1.10.10.10 17 87 6.9E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 SMART SM00895 102 223 1.0E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 58 1.0E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 58 74 1.0E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 SUPERFAMILY SSF48008 101 230 2.54E-27 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 Gene3D G3DSA:1.20.120.530 100 233 1.1E-32 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 Pfam PF00392 Bacterial regulatory proteins, gntR family 23 84 2.2E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 Pfam PF07729 FCD domain 102 223 2.5E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 SUPERFAMILY SSF46785 14 88 4.04E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06105 c173c8e1f9d0ca81c3b67ff2eb37d8a7 251 SMART SM00345 25 84 1.2E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS08245 ec3c97480c2592e98eb78545e56f5bf6 351 SUPERFAMILY SSF53659 23 347 4.61E-106 T 17-03-2017 SHXM_RS08245 ec3c97480c2592e98eb78545e56f5bf6 351 Pfam PF04166 Pyridoxal phosphate biosynthetic protein PdxA 52 342 5.7E-100 T 17-03-2017 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS08245 ec3c97480c2592e98eb78545e56f5bf6 351 Hamap MF_00536 4-hydroxythreonine-4-phosphate dehydrogenase [pdxA]. 21 346 33.976 T 17-03-2017 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS08245 ec3c97480c2592e98eb78545e56f5bf6 351 Gene3D G3DSA:3.40.718.10 23 346 2.2E-123 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS08245 ec3c97480c2592e98eb78545e56f5bf6 351 TIGRFAM TIGR00557 pdxA: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 25 346 6.4E-107 T 17-03-2017 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS34405 e771558d28764f6f37db4107b1a8ad42 137 Pfam PF01475 Ferric uptake regulator family 11 126 1.3E-25 T 17-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SHXM_RS34405 e771558d28764f6f37db4107b1a8ad42 137 SUPERFAMILY SSF46785 3 134 1.2E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34405 e771558d28764f6f37db4107b1a8ad42 137 Gene3D G3DSA:1.10.10.10 2 82 1.2E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 Gene3D G3DSA:1.10.10.10 158 252 2.2E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 SUPERFAMILY SSF46894 156 251 1.77E-27 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 Gene3D G3DSA:3.40.50.2300 2 121 2.6E-41 T 17-03-2017 SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 Pfam PF00072 Response regulator receiver domain 6 111 1.6E-20 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 SMART SM00448 3 110 1.5E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 Pfam PF00486 Transcriptional regulatory protein, C terminal 178 250 5.4E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 SUPERFAMILY SSF52172 2 121 3.56E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS08695 80a9eeccb447a3442c8b8b9124690d51 273 SMART SM00862 178 250 8.1E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 SUPERFAMILY SSF53901 10 327 6.22E-55 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 240 327 2.3E-25 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 10 327 2.2E-99 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 Gene3D G3DSA:3.40.47.10 168 326 2.0E-40 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 113 190 1.6E-26 T 17-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 Gene3D G3DSA:3.40.47.10 9 167 1.0E-53 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37880 68e705482cf20e2649beab7c957092dc 329 Hamap MF_01815 3-oxoacyl-[acyl-carrier-protein] synthase 3 [fabH]. 8 328 55.864 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS04405 12034227efc46342904d1486ba284d38 170 PIRSF PIRSF037663 4 168 1.3E-57 T 17-03-2017 IPR017255 Acetyltransferase, GNAT, predicted SHXM_RS04405 12034227efc46342904d1486ba284d38 170 Pfam PF00583 Acetyltransferase (GNAT) family 66 135 1.7E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS04405 12034227efc46342904d1486ba284d38 170 Gene3D G3DSA:3.40.630.30 4 164 2.0E-31 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS04405 12034227efc46342904d1486ba284d38 170 SUPERFAMILY SSF55729 1 138 8.06E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 PIRSF PIRSF001399 1 144 2.7E-50 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 Pfam PF01220 Dehydroquinase class II 4 138 3.4E-43 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 5 124 8.0E-66 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 Gene3D G3DSA:3.40.50.9100 3 142 6.5E-48 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 ProSitePatterns PS01029 Dehydroquinase class II signature. 7 24 - T 17-03-2017 IPR018509 Dehydroquinase, class II, conserved site GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 SUPERFAMILY SSF52304 3 142 3.92E-49 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS05050 698ef8177762e617abd632e6ada60eeb 144 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 144 49.121 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06780 2f991edbf26d4ea55c923c08c11ab684 379 SUPERFAMILY SSF51679 1 372 2.94E-73 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS06780 2f991edbf26d4ea55c923c08c11ab684 379 Gene3D G3DSA:3.20.20.30 1 372 5.4E-88 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS06780 2f991edbf26d4ea55c923c08c11ab684 379 Pfam PF00296 Luciferase-like monooxygenase 1 336 1.8E-45 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS18320 65f47dbc3705ea34baa6bc2ed29dc77f 136 Pfam PF10825 Protein of unknown function (DUF2752) 47 95 5.2E-17 T 17-03-2017 IPR021215 Protein of unknown function DUF2752 SHXM_RS02405 5a7c61e6664fe6c173d1c6373e49b01b 477 Gene3D G3DSA:3.90.1300.10 2 452 1.6E-103 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS02405 5a7c61e6664fe6c173d1c6373e49b01b 477 SUPERFAMILY SSF75304 2 448 7.46E-106 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS02405 5a7c61e6664fe6c173d1c6373e49b01b 477 Pfam PF01425 Amidase 22 436 9.5E-75 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS26095 cea62136e8307a727bab8e673cc4e18e 111 Gene3D G3DSA:3.30.565.10 24 102 2.0E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26095 cea62136e8307a727bab8e673cc4e18e 111 Pfam PF13581 Histidine kinase-like ATPase domain 24 100 3.4E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26095 cea62136e8307a727bab8e673cc4e18e 111 SUPERFAMILY SSF55874 15 101 6.94E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 ProSitePatterns PS00902 Glutamate 5-kinase signature. 241 258 - T 17-03-2017 IPR019797 Glutamate 5-kinase, conserved site GO:0004349|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 Gene3D G3DSA:2.30.130.10 305 397 1.2E-24 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 SMART SM00359 308 387 7.8E-15 T 17-03-2017 IPR002478 PUA domain GO:0003723 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 Gene3D G3DSA:3.40.1160.10 75 287 6.4E-49 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 Hamap MF_00456 Glutamate 5-kinase [proB]. 17 289 35.447 T 17-03-2017 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 Pfam PF01472 PUA domain 308 381 5.5E-18 T 17-03-2017 IPR002478 PUA domain GO:0003723 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 Pfam PF00696 Amino acid kinase family 18 269 2.7E-40 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 SUPERFAMILY SSF53633 17 287 4.09E-59 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 TIGRFAM TIGR01027 proB: glutamate 5-kinase 74 397 6.0E-119 T 17-03-2017 IPR005715 Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 SUPERFAMILY SSF88697 308 398 6.63E-22 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 PIRSF PIRSF000729 71 400 4.9E-112 T 17-03-2017 IPR011529 Glutamate 5-kinase GO:0004349|GO:0005737|GO:0006561 KEGG: 00330+2.7.2.11|KEGG: 00332+2.7.2.11|MetaCyc: PWY-3341|MetaCyc: PWY-6922 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 PRINTS PR00474 Glutamate 5-kinase family signature 76 90 2.8E-54 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 PRINTS PR00474 Glutamate 5-kinase family signature 110 138 2.8E-54 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 PRINTS PR00474 Glutamate 5-kinase family signature 150 171 2.8E-54 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 PRINTS PR00474 Glutamate 5-kinase family signature 182 209 2.8E-54 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS21585 03377be07d01119eb1a5340978eb4218 400 PRINTS PR00474 Glutamate 5-kinase family signature 243 263 2.8E-54 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS37625 affff54c6751afcaee2c67b9b16418ce 193 Gene3D G3DSA:3.10.129.10 21 165 1.1E-40 T 17-03-2017 IPR029069 HotDog domain SHXM_RS37625 affff54c6751afcaee2c67b9b16418ce 193 Pfam PF03061 Thioesterase superfamily 74 140 2.7E-10 T 17-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 SHXM_RS37625 affff54c6751afcaee2c67b9b16418ce 193 SUPERFAMILY SSF54637 22 158 4.49E-31 T 17-03-2017 IPR029069 HotDog domain SHXM_RS38390 1edb9b9da3164512ce7964fe017f79b5 311 SUPERFAMILY SSF51569 4 288 5.49E-39 T 17-03-2017 SHXM_RS38390 1edb9b9da3164512ce7964fe017f79b5 311 Pfam PF00682 HMGL-like 20 277 1.7E-25 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS38390 1edb9b9da3164512ce7964fe017f79b5 311 Gene3D G3DSA:3.20.20.70 5 286 1.5E-43 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 SUPERFAMILY SSF47413 15 62 2.67E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 SUPERFAMILY SSF53822 73 344 1.18E-82 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 SMART SM00354 15 82 2.8E-10 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 Gene3D G3DSA:3.40.50.2300 185 322 4.4E-54 T 17-03-2017 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 Gene3D G3DSA:3.40.50.2300 71 184 5.3E-29 T 17-03-2017 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 17 60 1.4E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 Gene3D G3DSA:1.10.260.40 15 60 9.9E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20745 e524c9198a6489c2095c0b57d2978795 347 Pfam PF13377 Periplasmic binding protein-like domain 180 341 1.9E-43 T 17-03-2017 SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 TIGRFAM TIGR01353 dGTP_triPase: putative dGTPase 46 452 1.3E-69 T 17-03-2017 IPR006261 Deoxyguanosinetriphosphate triphosphohydrolase GO:0000287|GO:0008832|GO:0046039 SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 Pfam PF13286 Phosphohydrolase-associated domain 359 450 1.8E-17 T 17-03-2017 IPR026875 Phosphohydrolase-associated domain SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 Gene3D G3DSA:1.10.3210.10 34 247 5.4E-63 T 17-03-2017 IPR006674 HD domain SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 SMART SM00471 92 261 9.5E-14 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 SUPERFAMILY SSF109604 40 201 1.59E-55 T 17-03-2017 SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 SUPERFAMILY SSF109604 232 444 1.59E-55 T 17-03-2017 SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 Hamap MF_01212 Deoxyguanosinetriphosphate triphosphohydrolase-like protein. 28 452 30.413 T 17-03-2017 IPR023023 Deoxyguanosinetriphosphate triphosphohydrolase, type 2 SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 Gene3D G3DSA:1.10.3410.10 248 379 3.5E-20 T 17-03-2017 IPR023293 Deoxyguanosinetriphosphate triphosphohydrolase, central domain SHXM_RS20615 2d131f77a5f3ba8008fa1b83e8fa464a 453 Pfam PF01966 HD domain 96 250 4.1E-16 T 17-03-2017 IPR006674 HD domain SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 Gene3D G3DSA:3.50.50.60 4 141 4.4E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 292 314 2.5E-33 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 263 279 2.5E-33 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 138 156 2.5E-33 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 176 194 2.5E-33 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 2.5E-33 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 347 455 5.6E-33 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 SUPERFAMILY SSF51905 2 336 2.16E-59 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 SUPERFAMILY SSF55424 343 465 2.41E-37 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 327 9.7E-66 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 408 423 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 343 364 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 264 278 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 176 201 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 38 53 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 307 314 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 141 150 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 430 450 2.7E-61 T 17-03-2017 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 39 49 - T 17-03-2017 IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site GO:0016668|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 4 465 4.5E-163 T 17-03-2017 IPR006258 Dihydrolipoamide dehydrogenase GO:0004148|GO:0050660|GO:0055114 KEGG: 00010+1.8.1.4|KEGG: 00020+1.8.1.4|KEGG: 00260+1.8.1.4|KEGG: 00280+1.8.1.4|KEGG: 00620+1.8.1.4|KEGG: 00640+1.8.1.4|MetaCyc: PWY-5046|MetaCyc: PWY-5084|Reactome: R-HSA-204174|Reactome: R-HSA-389661|Reactome: R-HSA-5362517|Reactome: R-HSA-6783984|Reactome: R-HSA-70268|Reactome: R-HSA-70895|Reactome: R-HSA-71064|Reactome: R-HSA-71403 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 Gene3D G3DSA:3.30.390.30 334 464 5.2E-43 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 Gene3D G3DSA:3.50.50.60 142 333 4.0E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44965 3c42ccdf4cff7b961782496d7808d0e1 466 PIRSF PIRSF000350 1 464 4.6E-76 T 17-03-2017 SHXM_RS16865 fa6b322cfb2f9ac11c3813f4101efa41 297 Pfam PF01674 Lipase (class 2) 63 237 1.1E-14 T 17-03-2017 IPR002918 Lipase EstA/Esterase EstB GO:0016787 KEGG: 00561+3.1.1.3|MetaCyc: PWY-6857 SHXM_RS16865 fa6b322cfb2f9ac11c3813f4101efa41 297 Gene3D G3DSA:3.40.50.1820 43 294 1.5E-79 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16865 fa6b322cfb2f9ac11c3813f4101efa41 297 SUPERFAMILY SSF53474 61 255 2.44E-29 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16545 41f39277c8bf3ab22cf6cfea53cc5456 268 Gene3D G3DSA:3.40.50.1110 37 257 1.7E-64 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS16545 41f39277c8bf3ab22cf6cfea53cc5456 268 SUPERFAMILY SSF52266 38 256 4.83E-61 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS16545 41f39277c8bf3ab22cf6cfea53cc5456 268 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 40 256 2.1E-19 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 96 105 4.8E-5 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 86 94 4.8E-5 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 PRINTS PR01264 Bacterial mechano-sensitive ion channel signature 3 17 4.8E-5 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 SUPERFAMILY SSF81330 9 121 2.09E-24 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 TIGRFAM TIGR00220 mscL: large conductance mechanosensitive channel protein 3 138 7.1E-22 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 Pfam PF01741 Large-conductance mechanosensitive channel, MscL 1 138 3.6E-34 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS32395 41f3e1e406eed62d6e3d25d78b21d713 154 ProSitePatterns PS01327 Large-conductance mechanosensitive channels mscL family signature. 10 23 - T 17-03-2017 IPR019823 Large-conductance mechanosensitive channel, conserved site SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 Gene3D G3DSA:3.30.465.10 126 246 4.2E-43 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 SUPERFAMILY SSF56176 33 246 1.31E-67 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 Pfam PF01565 FAD binding domain 70 209 2.1E-41 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 Pfam PF02913 FAD linked oxidases, C-terminal domain 246 481 2.5E-58 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 Gene3D G3DSA:3.30.43.10 26 125 8.8E-26 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 SUPERFAMILY SSF55103 249 482 4.41E-54 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS10940 872dfbadc806e1f32976d34081dec736 483 Gene3D G3DSA:1.10.45.10 443 482 2.1E-13 T 17-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 557 749 2.2E-49 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SMART SM00331 529 749 2.0E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SUPERFAMILY SSF55785 210 315 1.68E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Pfam PF13188 PAS domain 218 274 1.2E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SUPERFAMILY SSF55874 792 870 2.81E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SUPERFAMILY SSF81606 546 748 1.26E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Pfam PF13581 Histidine kinase-like ATPase domain 763 869 1.1E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Gene3D G3DSA:3.30.450.20 217 315 4.3E-6 T 17-03-2017 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Pfam PF13185 GAF domain 408 502 1.8E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SUPERFAMILY SSF103190 44 171 1.45E-29 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SUPERFAMILY SSF55781 387 510 2.84E-14 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Gene3D G3DSA:3.30.450.20 35 174 3.8E-37 T 17-03-2017 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Pfam PF17203 Single cache domain 3 43 170 7.6E-24 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 SMART SM00065 346 511 5.1E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS44970 f08651b1948cb26d3b2483868b8b46d5 883 Gene3D G3DSA:3.30.450.40 334 509 1.1E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27985 faffd3607fffca90d999ffbbe6dde477 198 Gene3D G3DSA:2.40.50.140 4 116 2.7E-41 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS27985 faffd3607fffca90d999ffbbe6dde477 198 Hamap MF_00984 Single-stranded DNA-binding protein. 4 113 30.118 T 17-03-2017 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 SHXM_RS27985 faffd3607fffca90d999ffbbe6dde477 198 SUPERFAMILY SSF50249 6 198 1.47E-41 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS27985 faffd3607fffca90d999ffbbe6dde477 198 Pfam PF00436 Single-strand binding protein family 7 107 1.0E-29 T 17-03-2017 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 Reactome: R-HSA-2151201 SHXM_RS27985 faffd3607fffca90d999ffbbe6dde477 198 TIGRFAM TIGR00621 ssb: single-stranded DNA-binding protein 6 116 8.1E-29 T 17-03-2017 IPR011344 Single-stranded DNA-binding protein GO:0003697|GO:0006260 Reactome: R-HSA-2151201 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 Gene3D G3DSA:3.20.20.60 167 323 5.1E-102 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 Gene3D G3DSA:3.20.20.60 2 72 5.1E-102 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 Pfam PF00224 Pyruvate kinase, barrel domain 1 336 1.1E-121 T 17-03-2017 IPR015793 Pyruvate kinase, barrel GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 SUPERFAMILY SSF51621 1 74 1.08E-97 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 SUPERFAMILY SSF51621 154 337 1.08E-97 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 TIGRFAM TIGR01064 pyruv_kin: pyruvate kinase 2 470 4.4E-164 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 Gene3D G3DSA:3.40.1380.20 324 470 3.4E-42 T 17-03-2017 IPR015794 Pyruvate kinase, alpha/beta GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 SUPERFAMILY SSF52935 321 470 2.22E-37 T 17-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 SUPERFAMILY SSF50800 70 164 4.36E-26 T 17-03-2017 IPR011037 Pyruvate kinase-like, insert domain SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 ProSitePatterns PS00110 Pyruvate kinase active site signature. 212 224 - T 17-03-2017 IPR018209 Pyruvate kinase, active site GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 59 75 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 266 290 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 291 309 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 241 265 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 310 326 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 214 240 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 PRINTS PR01050 Pyruvate kinase family signature 184 198 8.3E-65 T 17-03-2017 IPR001697 Pyruvate kinase GO:0000287|GO:0004743|GO:0006096|GO:0030955 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 Gene3D G3DSA:2.40.33.10 73 166 1.0E-27 T 17-03-2017 IPR015806 Pyruvate kinase, beta-barrel insert domain GO:0004743|GO:0006096 KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS18190 2e052ef6b7ca7fae56d93935af1ad110 476 Pfam PF02887 Pyruvate kinase, alpha/beta domain 356 468 1.1E-27 T 17-03-2017 IPR015795 Pyruvate kinase, C-terminal KEGG: 00010+2.7.1.40|KEGG: 00230+2.7.1.40|KEGG: 00620+2.7.1.40|MetaCyc: PWY-1042|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7218|MetaCyc: PWY-7383|Reactome: R-HSA-70171 SHXM_RS30725 c3a7b2d2f891e07552433a4addefd71a 149 Gene3D G3DSA:2.30.40.10 15 63 2.9E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS30725 c3a7b2d2f891e07552433a4addefd71a 149 SUPERFAMILY SSF51338 1 63 4.59E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 Pfam PF00155 Aminotransferase class I and II 148 417 2.1E-11 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 Gene3D G3DSA:3.40.640.10 128 332 4.5E-33 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 SUPERFAMILY SSF53383 89 415 3.37E-52 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 Pfam PF00392 Bacterial regulatory proteins, gntR family 13 74 5.9E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 Gene3D G3DSA:1.10.10.10 15 78 1.5E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 SUPERFAMILY SSF46785 15 78 3.04E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43865 7c30bc4abfba4b13b40de22f213b647f 440 SMART SM00345 15 74 2.6E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS14435 83d7a0594d81ec0eb95aa5ad98c3fcb7 810 SUPERFAMILY SSF117074 566 660 6.41E-14 T 17-03-2017 SHXM_RS14435 83d7a0594d81ec0eb95aa5ad98c3fcb7 810 SUPERFAMILY SSF63825 180 330 2.68E-6 T 17-03-2017 SHXM_RS14435 83d7a0594d81ec0eb95aa5ad98c3fcb7 810 Gene3D G3DSA:2.130.10.10 174 342 5.4E-5 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS14435 83d7a0594d81ec0eb95aa5ad98c3fcb7 810 Gene3D G3DSA:2.60.40.10 583 650 6.0E-12 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00862 16 93 7.4E-9 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Gene3D G3DSA:1.25.40.10 966 1021 1.8E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 PRINTS PR00364 Disease resistance protein signature 460 474 2.9E-5 T 17-03-2017 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 PRINTS PR00364 Disease resistance protein signature 298 313 2.9E-5 T 17-03-2017 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 PRINTS PR00364 Disease resistance protein signature 375 389 2.9E-5 T 17-03-2017 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Pfam PF03704 Bacterial transcriptional activator domain 101 245 2.2E-34 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Pfam PF13424 Tetratricopeptide repeat 867 939 1.3E-11 T 17-03-2017 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Pfam PF13424 Tetratricopeptide repeat 815 860 2.2E-8 T 17-03-2017 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SUPERFAMILY SSF48452 822 1034 2.85E-29 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SUPERFAMILY SSF48452 674 823 5.27E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Pfam PF00486 Transcriptional regulatory protein, C terminal 23 77 1.2E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM01043 101 245 2.4E-45 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 828 861 1.3E-7 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 948 981 63.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 868 901 81.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 988 1021 11.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 748 781 140.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 788 821 130.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SMART SM00028 908 941 3.3 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SUPERFAMILY SSF46894 2 77 9.92E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Gene3D G3DSA:1.25.40.10 197 221 8.6E-37 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Gene3D G3DSA:1.25.40.10 676 883 8.6E-37 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Gene3D G3DSA:1.10.10.10 9 78 1.9E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SUPERFAMILY SSF52540 269 525 2.7E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 SUPERFAMILY SSF48452 96 252 1.14E-32 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Pfam PF00931 NB-ARC domain 300 527 2.7E-11 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS10280 89e276a9d137ce18e1f06bb6c3efec1d 1042 Gene3D G3DSA:1.25.40.10 884 965 1.7E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 ProSitePatterns PS00078 CO II and nitrous oxide reductase dinuclear copper centers signature. 226 274 - T 17-03-2017 IPR001505 Copper centre Cu(A) GO:0005507 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 Gene3D G3DSA:1.10.287.90 41 124 9.7E-15 T 17-03-2017 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 Gene3D G3DSA:2.60.40.420 136 292 2.8E-41 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 PRINTS PR01166 Cytochrome c oxidase subunit II signature 263 280 9.7E-15 T 17-03-2017 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 PRINTS PR01166 Cytochrome c oxidase subunit II signature 99 111 9.7E-15 T 17-03-2017 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 PRINTS PR01166 Cytochrome c oxidase subunit II signature 245 262 9.7E-15 T 17-03-2017 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 PRINTS PR01166 Cytochrome c oxidase subunit II signature 225 245 9.7E-15 T 17-03-2017 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 PRINTS PR01166 Cytochrome c oxidase subunit II signature 134 153 9.7E-15 T 17-03-2017 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 SUPERFAMILY SSF81464 27 124 4.58E-18 T 17-03-2017 IPR011759 Cytochrome C oxidase subunit II, transmembrane domain GO:0016021|GO:0022900 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 SUPERFAMILY SSF49503 131 157 4.97E-41 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 SUPERFAMILY SSF49503 203 299 4.97E-41 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 Pfam PF00116 Cytochrome C oxidase subunit II, periplasmic domain 210 280 1.1E-17 T 17-03-2017 IPR002429 Cytochrome c oxidase subunit II C-terminal GO:0004129|GO:0005507|GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18910 5e324b4982f5db181f554ef29ca2ba6b 320 TIGRFAM TIGR02866 CoxB: cytochrome c oxidase, subunit II 52 289 1.1E-46 T 17-03-2017 IPR014222 Cytochrome c oxidase, subunit II GO:0016021|GO:0016491 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 Pfam PF12802 MarR family 41 97 2.4E-12 T 17-03-2017 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 58 74 9.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 124 144 9.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 94 110 9.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 75 90 9.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 SMART SM00347 34 134 4.6E-15 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 SUPERFAMILY SSF46785 7 146 3.35E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 Gene3D G3DSA:1.10.10.10 2 149 3.5E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40270 9433a82081ab288c19238b11f2027fc0 159 SMART SM00418 34 112 0.007 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS10825 8a2ae0fcd6b9a0b9db71a58a9fb43a2f 188 Gene3D G3DSA:2.60.120.10 45 127 3.4E-16 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS10825 8a2ae0fcd6b9a0b9db71a58a9fb43a2f 188 Pfam PF07883 Cupin domain 59 118 6.4E-10 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS10825 8a2ae0fcd6b9a0b9db71a58a9fb43a2f 188 SUPERFAMILY SSF51182 42 128 1.07E-15 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 57 185 5.0E-49 T 17-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 PIRSF PIRSF000185 22 448 1.4E-116 T 17-03-2017 IPR014362 Glutamate dehydrogenase GO:0016639|GO:0055114 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 SMART SM00839 205 446 6.2E-83 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 SUPERFAMILY SSF51735 203 447 9.3E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 122 135 - T 17-03-2017 IPR033524 Leu/Phe/Val dehydrogenases active site Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 Gene3D G3DSA:1.10.285.10 372 448 3.3E-17 T 17-03-2017 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 Gene3D G3DSA:1.10.285.10 5 67 3.3E-23 T 17-03-2017 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 203 446 3.9E-80 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 Gene3D G3DSA:3.40.192.10 68 188 2.3E-61 T 17-03-2017 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 114 128 1.3E-29 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 194 216 1.3E-29 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 371 382 1.3E-29 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 236 256 1.3E-29 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 Gene3D G3DSA:3.40.50.720 210 371 1.1E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27235 542063da155090c596e2d66af5d7de9b 448 SUPERFAMILY SSF53223 7 197 6.08E-75 T 17-03-2017 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 SUPERFAMILY SSF51905 328 411 1.34E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 SUPERFAMILY SSF51905 14 229 1.34E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Gene3D G3DSA:3.30.9.10 98 150 4.0E-4 T 17-03-2017 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Gene3D G3DSA:3.30.9.10 229 246 4.0E-4 T 17-03-2017 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Gene3D G3DSA:3.50.50.60 326 367 4.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Gene3D G3DSA:3.50.50.60 12 94 4.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Gene3D G3DSA:3.50.50.60 151 228 4.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Pfam PF04324 BFD-like [2Fe-2S] binding domain 409 459 4.3E-11 T 17-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 Pfam PF01266 FAD dependent oxidoreductase 15 364 4.5E-59 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS44950 75cf9c68a5c46ba610c64fb9d632b203 475 SUPERFAMILY SSF54373 230 325 3.01E-8 T 17-03-2017 SHXM_RS26245 bf2c49156117dadefc9281773f43436e 394 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 15 393 8.4E-116 T 17-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SHXM_RS26245 bf2c49156117dadefc9281773f43436e 394 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 222 363 2.6E-17 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS26245 bf2c49156117dadefc9281773f43436e 394 SUPERFAMILY SSF53756 10 394 1.29E-75 T 17-03-2017 SHXM_RS26245 bf2c49156117dadefc9281773f43436e 394 Gene3D G3DSA:3.40.50.2000 10 164 6.0E-6 T 17-03-2017 SHXM_RS26245 bf2c49156117dadefc9281773f43436e 394 ProSitePatterns PS00375 UDP-glycosyltransferases signature. 285 326 - T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS26245 bf2c49156117dadefc9281773f43436e 394 Gene3D G3DSA:3.40.50.2000 227 374 1.1E-34 T 17-03-2017 SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 SMART SM00922 128 259 2.9E-21 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 SUPERFAMILY SSF54826 1 112 1.34E-32 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 Gene3D G3DSA:3.30.390.10 8 115 2.3E-43 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 SUPERFAMILY SSF51604 98 387 2.18E-74 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 Pfam PF13378 Enolase C-terminal domain-like 134 379 3.5E-43 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 14 110 5.9E-32 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 85 110 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS11680 5ebf3fb791d23a0494f4b67f5aeab865 404 Gene3D G3DSA:3.20.20.120 116 367 7.2E-84 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS19815 bd5b16cca6550c2dc124c6ee530f74e0 488 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS19815 bd5b16cca6550c2dc124c6ee530f74e0 488 Pfam PF00171 Aldehyde dehydrogenase family 21 476 1.1E-150 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS19815 bd5b16cca6550c2dc124c6ee530f74e0 488 SUPERFAMILY SSF53720 5 480 8.12E-153 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS19815 bd5b16cca6550c2dc124c6ee530f74e0 488 Gene3D G3DSA:3.40.605.10 8 266 1.6E-82 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS19815 bd5b16cca6550c2dc124c6ee530f74e0 488 Gene3D G3DSA:3.40.309.10 267 443 1.2E-63 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS10790 e8ecc5958dae5aa016eb06a3e1bac60c 499 Pfam PF13857 Ankyrin repeats (many copies) 266 312 1.8E-6 T 17-03-2017 SHXM_RS10790 e8ecc5958dae5aa016eb06a3e1bac60c 499 Gene3D G3DSA:1.25.40.20 246 422 2.5E-22 T 17-03-2017 IPR020683 Ankyrin repeat-containing domain SHXM_RS10790 e8ecc5958dae5aa016eb06a3e1bac60c 499 SMART SM00248 275 304 0.0038 T 17-03-2017 IPR002110 Ankyrin repeat GO:0005515 SHXM_RS10790 e8ecc5958dae5aa016eb06a3e1bac60c 499 SMART SM00248 354 386 1000.0 T 17-03-2017 IPR002110 Ankyrin repeat GO:0005515 SHXM_RS10790 e8ecc5958dae5aa016eb06a3e1bac60c 499 SUPERFAMILY SSF48403 246 381 1.46E-19 T 17-03-2017 IPR020683 Ankyrin repeat-containing domain SHXM_RS49290 d6124614ed1c81661ad7ada81a5c86de 196 Pfam PF13358 DDE superfamily endonuclease 7 143 7.5E-27 T 17-03-2017 SHXM_RS48615 7c5bdabde08289780ca8f35199bece3e 210 Gene3D G3DSA:2.40.50.100 127 201 5.3E-27 T 17-03-2017 SHXM_RS48615 7c5bdabde08289780ca8f35199bece3e 210 Pfam PF00364 Biotin-requiring enzyme 129 200 3.7E-18 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS48615 7c5bdabde08289780ca8f35199bece3e 210 PRINTS PR01071 Acetyl-CoA biotin carboxyl carrier protein signature 163 176 9.5E-10 T 17-03-2017 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 SHXM_RS48615 7c5bdabde08289780ca8f35199bece3e 210 PRINTS PR01071 Acetyl-CoA biotin carboxyl carrier protein signature 131 144 9.5E-10 T 17-03-2017 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 SHXM_RS48615 7c5bdabde08289780ca8f35199bece3e 210 PRINTS PR01071 Acetyl-CoA biotin carboxyl carrier protein signature 148 162 9.5E-10 T 17-03-2017 IPR001249 Acetyl-CoA biotin carboxyl carrier GO:0003989|GO:0006633|GO:0009317 SHXM_RS48615 7c5bdabde08289780ca8f35199bece3e 210 SUPERFAMILY SSF51230 126 201 3.14E-21 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS44040 d29d135c91a58454faf874ecd5986e0c 155 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 15 101 3.3E-20 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS44040 d29d135c91a58454faf874ecd5986e0c 155 Gene3D G3DSA:2.30.110.10 10 154 2.8E-37 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS44040 d29d135c91a58454faf874ecd5986e0c 155 SUPERFAMILY SSF50475 7 150 2.32E-32 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 SMART SM00448 3 123 8.6E-12 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 Pfam PF00072 Response regulator receiver domain 5 102 1.3E-16 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 SUPERFAMILY SSF52172 2 181 2.88E-20 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 Gene3D G3DSA:1.10.10.10 154 214 3.0E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 166 182 5.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 182 194 5.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 152 166 5.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 SMART SM00421 149 206 1.8E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 Gene3D G3DSA:3.40.50.2300 3 153 1.7E-25 T 17-03-2017 SHXM_RS07630 92be7690e87590376bf76fb3b3542fdb 215 Pfam PF00196 Bacterial regulatory proteins, luxR family 151 197 2.9E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 Gene3D G3DSA:2.60.120.280 27 154 5.1E-12 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 Gene3D G3DSA:1.10.10.60 225 270 4.8E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 Pfam PF12833 Helix-turn-helix domain 192 269 8.9E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 SUPERFAMILY SSF51215 29 153 1.96E-19 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 SMART SM00342 186 268 6.1E-23 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 Pfam PF02311 AraC-like ligand binding domain 16 147 4.0E-23 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 SUPERFAMILY SSF46689 173 220 3.49E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 SUPERFAMILY SSF46689 223 271 5.82E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37210 3f56443d99e86492171448c0cea61bf2 283 Gene3D G3DSA:1.10.10.60 172 224 1.6E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 Pfam PF02254 TrkA-N domain 393 501 1.7E-19 T 17-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 Pfam PF02254 TrkA-N domain 78 148 8.7E-10 T 17-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 SUPERFAMILY SSF51735 389 505 8.44E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 Gene3D G3DSA:3.40.50.720 1 49 9.1E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 Gene3D G3DSA:3.40.50.720 81 148 9.1E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 Gene3D G3DSA:3.40.50.720 390 542 3.2E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46260 046d94ef9e55eaf19a08afe352f266b8 641 SUPERFAMILY SSF51735 78 147 6.3E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 Gene3D G3DSA:2.40.110.10 123 221 3.1E-25 T 17-03-2017 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 SUPERFAMILY SSF56645 2 240 1.09E-59 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 231 382 3.9E-20 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 8 120 9.4E-20 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 SUPERFAMILY SSF47203 231 384 1.03E-19 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 125 219 9.9E-16 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 Gene3D G3DSA:1.20.140.10 222 387 8.7E-29 T 17-03-2017 SHXM_RS47100 916175162a556e7e8402bd18dddff5f5 389 Gene3D G3DSA:1.10.540.10 1 122 4.9E-26 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 Gene3D G3DSA:1.10.1040.10 178 299 4.2E-29 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 TIGRFAM TIGR00745 apbA_panE: 2-dehydropantoate 2-reductase 2 298 4.0E-70 T 17-03-2017 IPR003710 Ketopantoate reductase ApbA/PanE GO:0005737|GO:0015940|GO:0016491|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654 SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 Pfam PF02558 Ketopantoate reductase PanE/ApbA 3 152 6.5E-39 T 17-03-2017 IPR013332 Ketopantoate reductase, N-terminal domain GO:0008677|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654 SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 SUPERFAMILY SSF48179 178 299 8.5E-26 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 Gene3D G3DSA:3.40.50.720 1 176 4.6E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 Pfam PF08546 Ketopantoate reductase PanE/ApbA C terminal 178 299 1.4E-25 T 17-03-2017 IPR013752 Ketopantoate reductase, C-terminal domain GO:0016491|GO:0050661|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654 SHXM_RS06750 dc513989350a570cde0ac301c21e6d15 322 SUPERFAMILY SSF51735 1 132 1.75E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 Pfam PF01016 Ribosomal L27 protein 2 80 1.5E-35 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 Gene3D G3DSA:2.40.50.100 20 82 3.4E-28 T 17-03-2017 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 SUPERFAMILY SSF110324 2 82 5.23E-31 T 17-03-2017 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 ProDom PD003114 RIBOSOMAL L27 50S RIBONUCLEOPROTEIN CHLOROPLAST MITOCHONDRIAL PEPTIDE 60S TRANSIT PRECURSOR 28 71 1.0E-17 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 ProSitePatterns PS00831 Ribosomal protein L27 signature. 34 48 - T 17-03-2017 IPR018261 Ribosomal protein L27, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 TIGRFAM TIGR00062 L27: ribosomal protein bL27 1 81 8.2E-35 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 PRINTS PR00063 Ribosomal protein L27 signature 54 78 3.9E-35 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 PRINTS PR00063 Ribosomal protein L27 signature 4 28 3.9E-35 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 PRINTS PR00063 Ribosomal protein L27 signature 29 53 3.9E-35 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21600 623e28876240b76ba63281ee1193e85f 85 Hamap MF_00539 50S ribosomal protein L27 [rpmA]. 1 83 26.947 T 17-03-2017 IPR001684 Ribosomal protein L27 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase 4 277 4.7E-105 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. 3 617 40.763 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 ProSitePatterns PS00802 Transketolase signature 2. 419 435 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Gene3D G3DSA:3.40.50.920 494 615 9.8E-27 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 SUPERFAMILY SSF52518 293 475 4.47E-54 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 TIGRFAM TIGR00204 dxs: 1-deoxy-D-xylulose-5-phosphate synthase 6 616 1.4E-183 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Pfam PF02780 Transketolase, C-terminal domain 492 607 3.3E-25 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 SUPERFAMILY SSF52518 2 343 5.4E-71 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 SMART SM00861 313 477 1.5E-56 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Gene3D G3DSA:3.40.50.970 2 190 9.7E-51 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Gene3D G3DSA:3.40.50.970 235 292 9.7E-51 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 SUPERFAMILY SSF52922 493 615 3.01E-24 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Pfam PF02779 Transketolase, pyrimidine binding domain 313 473 1.5E-36 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 Gene3D G3DSA:3.40.50.970 293 480 3.1E-56 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS16430 813ecb0efbd664a6c1fd829ada112515 632 ProSitePatterns PS00801 Transketolase signature 1. 29 48 - T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 324 414 1.1E-15 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 PIRSF PIRSF500136 1 423 1.2E-123 T 17-03-2017 IPR028359 UDP-N-acetyl-D-mannosamine/glucosamine dehydrogenase GO:0000271|GO:0016628|GO:0055114 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 Gene3D G3DSA:3.40.50.720 6 199 7.9E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 SUPERFAMILY SSF51735 6 199 6.39E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 5 32 - T 17-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 SUPERFAMILY SSF52413 310 415 3.4E-19 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 SUPERFAMILY SSF48179 205 298 3.91E-23 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 4 413 3.9E-100 T 17-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 Gene3D G3DSA:3.40.50.720 236 415 2.8E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 SMART SM00984 323 417 7.8E-18 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 5 187 8.7E-27 T 17-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 PIRSF PIRSF000124 3 421 9.2E-44 T 17-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 SHXM_RS31605 6d771b04dbcec99691365a1dc8cc817e 424 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 205 295 4.9E-23 T 17-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS15505 168053e4cbc0ef030c78bb05b5927dea 276 SUPERFAMILY SSF53167 13 240 6.95E-29 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS15505 168053e4cbc0ef030c78bb05b5927dea 276 Pfam PF01048 Phosphorylase superfamily 62 229 4.3E-17 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS15505 168053e4cbc0ef030c78bb05b5927dea 276 Gene3D G3DSA:3.40.50.1580 13 258 1.1E-30 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 SUPERFAMILY SSF46785 182 219 1.95E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 Gene3D G3DSA:1.10.10.10 6 46 2.2E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 SUPERFAMILY SSF54909 239 318 6.57E-9 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 Pfam PF13404 AsnC-type helix-turn-helix domain 181 217 3.5E-7 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 Pfam PF13404 AsnC-type helix-turn-helix domain 8 44 1.7E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 Gene3D G3DSA:3.30.70.920 240 314 3.1E-10 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 SMART SM00344 181 282 8.5E-8 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 Gene3D G3DSA:1.10.10.10 181 219 2.5E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46365 72b69ba3a98ec2f6408b8e02c3c76c34 327 Pfam PF01037 Lrp/AsnC ligand binding domain 243 312 1.0E-8 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS48450 cbe39e90934de0d0d0f93edb62d5b814 389 SUPERFAMILY SSF55347 129 303 4.91E-27 T 17-03-2017 SHXM_RS48450 cbe39e90934de0d0d0f93edb62d5b814 389 Gene3D G3DSA:3.30.360.10 140 371 1.6E-37 T 17-03-2017 SHXM_RS48450 cbe39e90934de0d0d0f93edb62d5b814 389 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 4 123 7.9E-16 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS48450 cbe39e90934de0d0d0f93edb62d5b814 389 SUPERFAMILY SSF51735 3 151 9.57E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48450 cbe39e90934de0d0d0f93edb62d5b814 389 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 135 199 7.9E-10 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS48450 cbe39e90934de0d0d0f93edb62d5b814 389 Gene3D G3DSA:3.40.50.720 3 139 1.7E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 SUPERFAMILY SSF46689 16 77 4.73E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 2.0E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 44 67 2.0E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 Gene3D G3DSA:1.10.10.60 17 61 4.2E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 Gene3D G3DSA:1.10.357.10 63 199 2.7E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 SUPERFAMILY SSF48498 81 199 5.72E-26 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 69 9.8E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08320 5ab12f72f6a63bc90f5c48140415bca9 203 Pfam PF16859 Bacterial transcriptional repressor C-terminal 81 191 2.8E-31 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS24100 4e0c9024f37cafe68682857603b8c1fe 229 Gene3D G3DSA:3.30.160.100 2 101 1.3E-25 T 17-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SHXM_RS24100 4e0c9024f37cafe68682857603b8c1fe 229 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein 3 100 3.1E-19 T 17-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SHXM_RS24100 4e0c9024f37cafe68682857603b8c1fe 229 TIGRFAM TIGR00741 yfiA: ribosomal subunit interface protein 2 104 1.3E-21 T 17-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SHXM_RS24100 4e0c9024f37cafe68682857603b8c1fe 229 Pfam PF16321 Sigma 54 modulation/S30EA ribosomal protein C terminus 153 207 1.9E-22 T 17-03-2017 IPR032528 Sigma 54 modulation/S30EA ribosomal protein, C-terminal SHXM_RS24100 4e0c9024f37cafe68682857603b8c1fe 229 SUPERFAMILY SSF69754 3 108 6.28E-22 T 17-03-2017 IPR003489 Ribosomal protein S30Ae/sigma 54 modulation protein GO:0044238 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 Gene3D G3DSA:3.10.270.10 4 287 7.7E-108 T 17-03-2017 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 PRINTS PR00093 Uricase signature 85 98 6.3E-19 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 PRINTS PR00093 Uricase signature 146 162 6.3E-19 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 PRINTS PR00093 Uricase signature 162 174 6.3E-19 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 PRINTS PR00093 Uricase signature 10 21 6.3E-19 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 PRINTS PR00093 Uricase signature 49 63 6.3E-19 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 SUPERFAMILY SSF55620 137 288 1.0E-56 T 17-03-2017 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 Pfam PF01014 Uricase 140 278 2.9E-32 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 Pfam PF01014 Uricase 8 130 1.0E-17 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 PIRSF PIRSF000241 2 290 2.9E-104 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 TIGRFAM TIGR03383 urate_oxi: urate oxidase 5 283 2.5E-106 T 17-03-2017 IPR002042 Uricase KEGG: 00230+1.7.3.3|KEGG: 00232+1.7.3.3|MetaCyc: PWY-5691 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 ProDom PD003367 URICASE OXIDOREDUCTASE URATE OXIDASE METABOLISM PURINE PEROXISOME ACETYLATION II DIRECT 176 283 2.0E-38 T 17-03-2017 SHXM_RS38955 68552146b7aa4ec735a7a8d5c9892066 293 SUPERFAMILY SSF55620 4 129 2.13E-39 T 17-03-2017 SHXM_RS15950 3513c5ee00fb68fb780be42ffa8ee71a 416 Pfam PF02163 Peptidase family M50 168 217 3.2E-7 T 17-03-2017 IPR008915 Peptidase M50 GO:0004222|GO:0006508 Reactome: R-HSA-1655829|Reactome: R-HSA-381033 SHXM_RS15950 3513c5ee00fb68fb780be42ffa8ee71a 416 SUPERFAMILY SSF54631 289 405 2.36E-11 T 17-03-2017 SHXM_RS15950 3513c5ee00fb68fb780be42ffa8ee71a 416 PIRSF PIRSF006404 32 413 1.9E-102 T 17-03-2017 IPR016483 Uncharacterised conserved protein UCP006404, peptidase M50/CBS SHXM_RS15950 3513c5ee00fb68fb780be42ffa8ee71a 416 Gene3D G3DSA:3.10.580.10 289 404 9.6E-11 T 17-03-2017 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 Gene3D G3DSA:3.90.380.10 157 406 3.1E-12 T 17-03-2017 IPR015879 Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain GO:0005506|GO:0016708|GO:0019439|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 SUPERFAMILY SSF55961 169 226 6.12E-43 T 17-03-2017 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 SUPERFAMILY SSF55961 255 417 6.12E-43 T 17-03-2017 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 38 63 3.1E-20 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 187 209 3.1E-20 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 68 83 3.1E-20 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 89 109 3.1E-20 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 PRINTS PR00090 Ring hydroxylating dioxygenase alpha-subunit signature 110 130 3.1E-20 T 17-03-2017 IPR001663 Aromatic-ring-hydroxylating dioxygenase, alpha subunit GO:0005506|GO:0006725|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 SUPERFAMILY SSF50022 25 164 1.31E-47 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 Pfam PF00848 Ring hydroxylating alpha subunit (catalytic domain) 187 420 2.8E-43 T 17-03-2017 IPR015879 Aromatic-ring-hydroxylating dioxygenase, alpha subunit, C-terminal domain GO:0005506|GO:0016708|GO:0019439|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 Pfam PF00355 Rieske [2Fe-2S] domain 53 135 3.0E-16 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS47855 5d1d114073ee7699b7dc8f1634db9b89 425 Gene3D G3DSA:2.102.10.10 52 156 9.3E-37 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS43420 6ab26840e04d4136a6ae628a76b84d28 702 SUPERFAMILY SSF50475 553 674 9.91E-20 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS43420 6ab26840e04d4136a6ae628a76b84d28 702 Gene3D G3DSA:2.30.110.10 554 667 7.6E-22 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS43420 6ab26840e04d4136a6ae628a76b84d28 702 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 566 640 3.9E-7 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS37840 72ce5cb450823b8a4d73ae6385fa148f 137 Gene3D G3DSA:3.40.1260.10 11 132 1.2E-9 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS37840 72ce5cb450823b8a4d73ae6385fa148f 137 SUPERFAMILY SSF75169 11 132 7.91E-10 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS33600 3f9480f7b46781802beddbe387473cf0 239 SUPERFAMILY SSF53335 29 212 1.75E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS33600 3f9480f7b46781802beddbe387473cf0 239 Gene3D G3DSA:3.40.50.150 27 210 5.6E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS33600 3f9480f7b46781802beddbe387473cf0 239 Pfam PF13649 Methyltransferase domain 65 166 2.2E-15 T 17-03-2017 SHXM_RS39340 58368ebc79c9001eae2627e8c178202f 280 Gene3D G3DSA:3.30.420.10 176 279 1.3E-7 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS39340 58368ebc79c9001eae2627e8c178202f 280 SUPERFAMILY SSF53098 169 279 4.36E-10 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS11600 4c77c975e2bd670faf2b75cabd95db7c 507 SUPERFAMILY SSF53720 15 499 2.49E-158 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS11600 4c77c975e2bd670faf2b75cabd95db7c 507 Gene3D G3DSA:3.40.309.10 272 470 5.5E-57 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS11600 4c77c975e2bd670faf2b75cabd95db7c 507 Pfam PF00171 Aldehyde dehydrogenase family 33 494 6.8E-158 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS11600 4c77c975e2bd670faf2b75cabd95db7c 507 Gene3D G3DSA:3.40.605.10 19 271 1.3E-89 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS11600 4c77c975e2bd670faf2b75cabd95db7c 507 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 295 306 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS11600 4c77c975e2bd670faf2b75cabd95db7c 507 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 262 269 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS15520 7e214613db1b124f45096868037e723c 418 Pfam PF13353 4Fe-4S single cluster domain 57 172 9.6E-6 T 17-03-2017 SHXM_RS15520 7e214613db1b124f45096868037e723c 418 Gene3D G3DSA:3.20.20.70 51 365 4.7E-45 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS15520 7e214613db1b124f45096868037e723c 418 Pfam PF13186 Iron-sulfur cluster-binding domain 284 349 3.1E-8 T 17-03-2017 IPR023885 4Fe4S-binding SPASM domain SHXM_RS15520 7e214613db1b124f45096868037e723c 418 SUPERFAMILY SSF102114 53 358 2.35E-37 T 17-03-2017 SHXM_RS15520 7e214613db1b124f45096868037e723c 418 TIGRFAM TIGR04085 rSAM_more_4Fe4S: radical SAM additional 4Fe4S-binding SPASM domain 283 367 3.6E-9 T 17-03-2017 IPR023885 4Fe4S-binding SPASM domain SHXM_RS15520 7e214613db1b124f45096868037e723c 418 Pfam PF04055 Radical SAM superfamily 56 218 5.4E-12 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS15520 7e214613db1b124f45096868037e723c 418 SMART SM00729 49 258 0.0078 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS44295 e5f86ee77a75fdbfe56f06d120a21319 138 Gene3D G3DSA:3.40.309.10 33 97 5.0E-6 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS44295 e5f86ee77a75fdbfe56f06d120a21319 138 SUPERFAMILY SSF53720 33 119 6.71E-13 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS44295 e5f86ee77a75fdbfe56f06d120a21319 138 Pfam PF00171 Aldehyde dehydrogenase family 38 105 2.2E-7 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 SUPERFAMILY SSF46785 6 53 2.51E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 Gene3D G3DSA:3.30.70.920 244 317 1.2E-13 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 SUPERFAMILY SSF46785 183 230 2.41E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 SMART SM00344 6 110 4.8E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 SMART SM00344 183 284 3.0E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 SUPERFAMILY SSF54909 240 317 3.49E-11 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 Pfam PF01037 Lrp/AsnC ligand binding domain 246 314 2.2E-11 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 Pfam PF13404 AsnC-type helix-turn-helix domain 7 47 9.2E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 Pfam PF13404 AsnC-type helix-turn-helix domain 183 220 1.4E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 Gene3D G3DSA:1.10.10.10 183 224 3.7E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 Gene3D G3DSA:1.10.10.10 6 53 1.2E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 6 22 2.1E-7 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 33 52 2.1E-7 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS27700 e34df6591be3ade09ef77653e1e8f0ea 334 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 22 33 2.1E-7 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 Pfam PF00582 Universal stress protein family 8 142 1.7E-22 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 Pfam PF00582 Universal stress protein family 176 317 1.1E-12 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 Gene3D G3DSA:3.40.50.620 174 317 2.4E-20 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 Gene3D G3DSA:3.40.50.620 7 142 3.2E-27 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 SUPERFAMILY SSF52402 8 145 2.51E-25 T 17-03-2017 SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 SUPERFAMILY SSF52402 152 317 7.18E-17 T 17-03-2017 SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 PRINTS PR01438 Universal stress protein signature 5 23 9.1E-14 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 PRINTS PR01438 Universal stress protein signature 120 142 9.1E-14 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43305 c47f56e32930119868ff1250c35a6f83 319 PRINTS PR01438 Universal stress protein signature 102 114 9.1E-14 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08660 32eba775cf2728c560b863ad1dcfbf2b 427 PIRSF PIRSF001434 7 386 5.0E-111 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS08660 32eba775cf2728c560b863ad1dcfbf2b 427 SUPERFAMILY SSF53383 56 384 3.46E-77 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS08660 32eba775cf2728c560b863ad1dcfbf2b 427 Gene3D G3DSA:3.90.1150.10 269 384 1.5E-26 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS08660 32eba775cf2728c560b863ad1dcfbf2b 427 Gene3D G3DSA:3.40.640.10 18 268 8.9E-70 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS08660 32eba775cf2728c560b863ad1dcfbf2b 427 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 19 383 3.7E-88 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS30215 d00752a6468f9091757a5f8db88a58a7 295 SMART SM00530 17 72 2.8E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS30215 d00752a6468f9091757a5f8db88a58a7 295 Gene3D G3DSA:1.10.260.40 14 70 1.8E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30215 d00752a6468f9091757a5f8db88a58a7 295 SUPERFAMILY SSF47413 11 73 5.35E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30215 d00752a6468f9091757a5f8db88a58a7 295 Pfam PF13560 Helix-turn-helix domain 13 67 2.6E-8 T 17-03-2017 SHXM_RS16915 ffa98326df4eadf3403b807ed310785b 330 SUPERFAMILY SSF53850 20 33 8.95E-45 T 17-03-2017 SHXM_RS16915 ffa98326df4eadf3403b807ed310785b 330 SUPERFAMILY SSF53850 71 312 8.95E-45 T 17-03-2017 SHXM_RS16915 ffa98326df4eadf3403b807ed310785b 330 Gene3D G3DSA:3.40.190.10 69 190 9.3E-36 T 17-03-2017 SHXM_RS16915 ffa98326df4eadf3403b807ed310785b 330 SMART SM00062 81 314 2.5E-29 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS16915 ffa98326df4eadf3403b807ed310785b 330 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 86 311 8.3E-43 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS16915 ffa98326df4eadf3403b807ed310785b 330 Gene3D G3DSA:3.40.190.10 191 262 3.8E-17 T 17-03-2017 SHXM_RS48050 f4c7fe96918c2f96599eecb93e2a9016 35 SUPERFAMILY SSF110221 2 34 6.8E-7 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS48050 f4c7fe96918c2f96599eecb93e2a9016 35 Gene3D G3DSA:2.80.10.50 2 34 5.8E-7 T 17-03-2017 SHXM_RS48050 f4c7fe96918c2f96599eecb93e2a9016 35 Pfam PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain 1 35 2.1E-9 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS02455 564872586eaf332ca0b936269a08919e 241 Gene3D G3DSA:2.70.70.10 25 198 9.3E-23 T 17-03-2017 SHXM_RS02455 564872586eaf332ca0b936269a08919e 241 Pfam PF01551 Peptidase family M23 90 197 2.3E-13 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS02455 564872586eaf332ca0b936269a08919e 241 SUPERFAMILY SSF51261 81 104 2.46E-19 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS02455 564872586eaf332ca0b936269a08919e 241 SUPERFAMILY SSF51261 133 197 2.46E-19 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 SUPERFAMILY SSF46785 9 95 1.48E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 Gene3D G3DSA:1.10.10.10 7 93 1.9E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 Pfam PF01022 Bacterial regulatory protein, arsR family 20 64 1.3E-14 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 SMART SM00418 13 91 1.5E-26 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 47 62 1.5E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 15 30 1.5E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS02730 7825bcb91e9b4721f91adc59228c1ec3 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 62 77 1.5E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS12185 f47a3673b112fda8d7df9576d645c57a 291 Gene3D G3DSA:3.20.20.60 11 234 3.9E-48 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS12185 f47a3673b112fda8d7df9576d645c57a 291 Pfam PF13714 Phosphoenolpyruvate phosphomutase 16 250 1.1E-64 T 17-03-2017 SHXM_RS12185 f47a3673b112fda8d7df9576d645c57a 291 SUPERFAMILY SSF51621 11 257 5.38E-49 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 ProSitePatterns PS01071 grpE protein signature. 146 189 - T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 Pfam PF01025 GrpE 45 191 2.8E-34 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 Hamap MF_01151 Protein GrpE [grpE]. 3 191 17.137 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 PRINTS PR00773 GrpE protein signature 170 189 4.2E-25 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 PRINTS PR00773 GrpE protein signature 68 84 4.2E-25 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 PRINTS PR00773 GrpE protein signature 143 158 4.2E-25 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 PRINTS PR00773 GrpE protein signature 96 111 4.2E-25 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 SUPERFAMILY SSF58014 48 134 2.09E-17 T 17-03-2017 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 Gene3D G3DSA:3.90.20.20 48 134 1.8E-20 T 17-03-2017 IPR013805 GrpE nucleotide exchange factor, coiled-coil Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 Gene3D G3DSA:2.30.22.10 135 192 6.8E-22 T 17-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 SHXM_RS29090 72f9dc79df632b453a41e4a6a7fe935c 219 SUPERFAMILY SSF51064 137 192 5.1E-16 T 17-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 SHXM_RS04700 3893ea2a48c28f018134e1894d7481e5 326 Gene3D G3DSA:3.40.190.10 122 222 8.3E-17 T 17-03-2017 SHXM_RS04700 3893ea2a48c28f018134e1894d7481e5 326 Pfam PF09084 NMT1/THI5 like 50 248 3.8E-18 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS04700 3893ea2a48c28f018134e1894d7481e5 326 Pfam PF10518 TAT (twin-arginine translocation) pathway signal sequence 3 26 1.6E-5 T 17-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SHXM_RS04700 3893ea2a48c28f018134e1894d7481e5 326 TIGRFAM TIGR01728 SsuA_fam: ABC transporter, substrate-binding protein, aliphatic sulfonates family 35 320 3.0E-61 T 17-03-2017 IPR010067 Aliphatic sulfonates-binding protein GO:0006790|GO:0006810|GO:0016020 SHXM_RS04700 3893ea2a48c28f018134e1894d7481e5 326 TIGRFAM TIGR01409 TAT_signal_seq: Tat (twin-arginine translocation) pathway signal sequence 4 23 5.1E-4 T 17-03-2017 IPR019546 Twin-arginine translocation pathway, signal sequence, bacterial/archaeal SHXM_RS04700 3893ea2a48c28f018134e1894d7481e5 326 SUPERFAMILY SSF53850 35 250 2.05E-37 T 17-03-2017 SHXM_RS21745 b00e59133f11b748e07aa567a0c8e6f4 380 SUPERFAMILY SSF81606 201 340 3.92E-5 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21745 b00e59133f11b748e07aa567a0c8e6f4 380 SMART SM00331 170 379 1.9E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21745 b00e59133f11b748e07aa567a0c8e6f4 380 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 197 379 6.9E-32 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS32645 ead9884bc2c5c2deb0433b506c13460f 166 SUPERFAMILY SSF55826 17 162 3.79E-37 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS32645 ead9884bc2c5c2deb0433b506c13460f 166 Gene3D G3DSA:3.90.960.10 15 163 4.6E-46 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS32645 ead9884bc2c5c2deb0433b506c13460f 166 Pfam PF04073 Aminoacyl-tRNA editing domain 35 151 2.1E-29 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS48155 fa4a484c1838ffba8726f5911adc9861 163 Gene3D G3DSA:1.10.10.10 8 140 4.2E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48155 fa4a484c1838ffba8726f5911adc9861 163 Pfam PF12802 MarR family 42 94 1.9E-10 T 17-03-2017 SHXM_RS48155 fa4a484c1838ffba8726f5911adc9861 163 SMART SM00347 31 130 3.5E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS48155 fa4a484c1838ffba8726f5911adc9861 163 ProSitePatterns PS01117 MarR-type HTH domain signature. 68 103 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS48155 fa4a484c1838ffba8726f5911adc9861 163 SUPERFAMILY SSF46785 11 142 4.71E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 SUPERFAMILY SSF55031 295 349 3.26E-10 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 SUPERFAMILY SSF55031 205 247 3.26E-10 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 Pfam PF07687 Peptidase dimerisation domain 203 330 1.9E-13 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 Pfam PF01546 Peptidase family M20/M25/M40 85 444 2.1E-38 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 Gene3D G3DSA:3.40.630.10 381 445 3.4E-56 T 17-03-2017 SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 Gene3D G3DSA:3.40.630.10 15 214 3.4E-56 T 17-03-2017 SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 Gene3D G3DSA:3.30.70.360 296 335 3.7E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 Gene3D G3DSA:3.30.70.360 215 254 3.7E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 ProSitePatterns PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 84 93 - T 17-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 SUPERFAMILY SSF53187 13 205 8.0E-54 T 17-03-2017 SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 SUPERFAMILY SSF53187 356 445 8.0E-54 T 17-03-2017 SHXM_RS14670 8fb388c5ae1a15b1092880f7c78403b2 446 ProSitePatterns PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 119 158 - T 17-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 207 227 5.6E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 5.6E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 5.6E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 5.6E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 5.6E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 Gene3D G3DSA:3.40.50.720 3 244 1.7E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 185 0.0015 T 17-03-2017 SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 SUPERFAMILY SSF51735 5 244 2.05E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38690 11c51e0201beb28cd3ab4e97bb784c90 246 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 244 4.1E-59 T 17-03-2017 SHXM_RS46590 d81b87e82ef9eb37b37648ff22b05ebd 436 Gene3D G3DSA:1.20.1250.20 232 415 8.5E-15 T 17-03-2017 SHXM_RS46590 d81b87e82ef9eb37b37648ff22b05ebd 436 Gene3D G3DSA:1.20.1250.20 26 196 5.8E-19 T 17-03-2017 SHXM_RS46590 d81b87e82ef9eb37b37648ff22b05ebd 436 Pfam PF07690 Major Facilitator Superfamily 26 346 1.3E-18 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46590 d81b87e82ef9eb37b37648ff22b05ebd 436 SUPERFAMILY SSF103473 25 415 4.45E-36 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 TIGRFAM TIGR03921 T7SS_mycosin: type VII secretion-associated serine protease mycosin 82 420 1.3E-99 T 17-03-2017 IPR023834 Type VII secretion system peptidase S8A, mycosin-1 SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 PRINTS PR00723 Subtilisin serine protease family (S8) signature 83 102 6.3E-17 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 PRINTS PR00723 Subtilisin serine protease family (S8) signature 133 146 6.3E-17 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 PRINTS PR00723 Subtilisin serine protease family (S8) signature 294 310 6.3E-17 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 137 147 - T 17-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 Gene3D G3DSA:3.40.50.200 60 356 1.6E-78 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 SUPERFAMILY SSF52743 60 353 3.14E-78 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 295 305 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 88 99 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS36980 849c5df4e43dfcf0e117849ff1621ec0 427 Pfam PF00082 Subtilase family 83 344 3.7E-49 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Gene3D G3DSA:3.40.50.970 298 478 1.5E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 SUPERFAMILY SSF52922 488 616 3.66E-29 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Pfam PF02780 Transketolase, C-terminal domain 491 609 6.5E-32 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 SUPERFAMILY SSF52518 313 479 2.62E-49 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Pfam PF02779 Transketolase, pyrimidine binding domain 317 478 3.4E-34 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Gene3D G3DSA:3.40.50.970 236 297 1.4E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Gene3D G3DSA:3.40.50.970 1 188 1.4E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase 4 279 3.3E-108 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. 3 618 40.825 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 TIGRFAM TIGR00204 dxs: 1-deoxy-D-xylulose-5-phosphate synthase 6 617 1.3E-183 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 SMART SM00861 316 480 4.6E-47 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 Gene3D G3DSA:3.40.50.920 488 615 1.9E-32 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 ProSitePatterns PS00802 Transketolase signature 2. 422 438 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 SUPERFAMILY SSF52518 2 346 9.15E-70 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS13305 50ed12de1eea3ce4bf42f99428543a19 649 ProSitePatterns PS00801 Transketolase signature 1. 29 48 - T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS08590 5c4f0de0f6cbf37904091ae2fe46ae8b 256 Gene3D G3DSA:3.40.50.1110 10 194 2.7E-33 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS08590 5c4f0de0f6cbf37904091ae2fe46ae8b 256 SUPERFAMILY SSF52266 10 192 5.19E-35 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS08590 5c4f0de0f6cbf37904091ae2fe46ae8b 256 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 12 183 1.1E-21 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 ProSitePatterns PS00954 Imidazoleglycerol-phosphate dehydratase signature 1. 62 75 - T 17-03-2017 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 Gene3D G3DSA:3.30.230.40 91 197 1.8E-28 T 17-03-2017 SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 Gene3D G3DSA:3.30.230.40 3 89 7.3E-37 T 17-03-2017 SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 SUPERFAMILY SSF54211 88 181 5.31E-30 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 Hamap MF_00076 Imidazoleglycerol-phosphate dehydratase [hisB]. 3 197 41.147 T 17-03-2017 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 ProSitePatterns PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. 158 170 - T 17-03-2017 IPR020565 Imidazoleglycerol-phosphate dehydratase, conserved site GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 SUPERFAMILY SSF54211 3 86 8.6E-33 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS18410 1b11d547da72b18d7f9a7ef85bff59a9 197 Pfam PF00475 Imidazoleglycerol-phosphate dehydratase 32 176 1.8E-61 T 17-03-2017 IPR000807 Imidazoleglycerol-phosphate dehydratase GO:0000105|GO:0004424 KEGG: 00340+4.2.1.19 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 SMART SM00421 156 213 2.1E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 Gene3D G3DSA:1.10.10.10 127 219 1.8E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 Pfam PF00196 Bacterial regulatory proteins, luxR family 158 213 7.5E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 SMART SM00448 3 118 1.7E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 SUPERFAMILY SSF46894 147 219 2.86E-22 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 SUPERFAMILY SSF52172 2 135 6.4E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 ProSitePatterns PS00622 LuxR-type HTH domain signature. 173 200 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 189 2.6E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 173 2.6E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 189 201 2.6E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 Gene3D G3DSA:3.40.50.2300 1 126 1.5E-35 T 17-03-2017 SHXM_RS28800 b287025747754fdcf0c5c7193e547680 226 Pfam PF00072 Response regulator receiver domain 5 116 3.6E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26150 6ea9e1ea6d682aad619699bac8c84e15 579 Pfam PF12708 Pectate lyase superfamily protein 99 186 7.6E-19 T 17-03-2017 IPR024535 Pectate lyase superfamily protein SHXM_RS26150 6ea9e1ea6d682aad619699bac8c84e15 579 Gene3D G3DSA:2.160.20.10 96 223 1.4E-40 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS26150 6ea9e1ea6d682aad619699bac8c84e15 579 Gene3D G3DSA:2.160.20.10 364 521 1.4E-40 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS26150 6ea9e1ea6d682aad619699bac8c84e15 579 SUPERFAMILY SSF51126 365 519 6.28E-13 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS26150 6ea9e1ea6d682aad619699bac8c84e15 579 SUPERFAMILY SSF51126 100 175 6.28E-13 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS26150 6ea9e1ea6d682aad619699bac8c84e15 579 SUPERFAMILY SSF51126 96 197 2.28E-23 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS32980 de3e336b3e4157f573355019e05cc09e 316 Gene3D G3DSA:1.10.3720.10 86 306 1.6E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32980 de3e336b3e4157f573355019e05cc09e 316 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 311 1.3E-38 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32980 de3e336b3e4157f573355019e05cc09e 316 SUPERFAMILY SSF161098 90 295 1.44E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 SMART SM00382 541 689 5.9E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 SMART SM00382 204 348 6.5E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Pfam PF02151 UvrB/uvrC motif 421 453 1.8E-5 T 17-03-2017 IPR001943 UVR domain GO:0005515 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Gene3D G3DSA:3.40.50.300 167 347 5.2E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 16 68 3.2E-19 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 93 142 4.5E-17 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 619 637 6.2E-40 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 545 563 6.2E-40 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 590 608 6.2E-40 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 652 666 6.2E-40 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 SMART SM01086 719 812 9.9E-37 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Gene3D G3DSA:1.10.1780.10 1 143 3.1E-54 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 719 798 1.7E-26 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 SUPERFAMILY SSF52540 167 452 5.68E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 SUPERFAMILY SSF81923 3 144 3.63E-33 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Gene3D G3DSA:3.40.50.300 702 730 2.3E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Gene3D G3DSA:3.40.50.300 494 667 2.3E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 209 321 1.6E-12 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Gene3D G3DSA:1.10.8.60 350 432 2.7E-34 T 17-03-2017 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Gene3D G3DSA:1.10.8.60 731 816 1.5E-31 T 17-03-2017 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 Pfam PF07724 AAA domain (Cdc48 subfamily) 541 712 9.7E-55 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 SUPERFAMILY SSF52540 490 801 1.27E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26280 ce8d5ae087599077822264353a8b3fb1 841 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 299 311 - T 17-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 SUPERFAMILY SSF51569 5 336 7.62E-94 T 17-03-2017 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 PIRSF PIRSF001359 6 338 1.6E-61 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 TIGRFAM TIGR01520 FruBisAldo_II_A: fructose-bisphosphate aldolase, class II 3 337 2.3E-127 T 17-03-2017 IPR006411 Fructose-bisphosphate aldolase, class II, yeast/E. coli subtype GO:0004332|GO:0006096 KEGG: 00010+4.1.2.13|KEGG: 00030+4.1.2.13|KEGG: 00051+4.1.2.13|KEGG: 00680+4.1.2.13|KEGG: 00710+4.1.2.13|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7385 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 Gene3D G3DSA:3.20.20.70 3 337 4.9E-113 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 TIGRFAM TIGR00167 cbbA: ketose-bisphosphate aldolase 10 337 1.2E-69 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 ProSitePatterns PS00602 Fructose-bisphosphate aldolase class-II signature 1. 86 97 - T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS29240 5ff513550aa2e2e79bc5b301b29067fc 340 Pfam PF01116 Fructose-bisphosphate aldolase class-II 9 336 9.3E-77 T 17-03-2017 IPR000771 Ketose-bisphosphate aldolase, class-II GO:0005975|GO:0008270|GO:0016832 SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 Gene3D G3DSA:1.10.10.10 78 143 5.4E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 SMART SM00866 178 315 3.8E-18 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 Gene3D G3DSA:3.40.1410.10 144 318 3.9E-40 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 Pfam PF07702 UTRA domain 184 315 7.3E-20 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 SUPERFAMILY SSF46785 76 152 4.54E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 SUPERFAMILY SSF64288 185 320 9.11E-26 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 Pfam PF00392 Bacterial regulatory proteins, gntR family 79 141 3.7E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS01655 6cbb06700f3dd42cc08f07de8e4adcce 331 SMART SM00345 82 141 1.8E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 SUPERFAMILY SSF46785 15 86 2.14E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 Pfam PF07729 FCD domain 92 216 4.4E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 Gene3D G3DSA:1.20.120.530 87 227 3.7E-30 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 Gene3D G3DSA:1.10.10.10 11 82 6.9E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 SUPERFAMILY SSF48008 89 223 1.78E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 SMART SM00895 92 217 1.4E-15 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 SMART SM00345 24 82 4.4E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 82 1.5E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 56 72 1.8E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS12085 576f20e32273e0bbce5c310b97d74fcb 231 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 56 1.8E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 Pfam PF07687 Peptidase dimerisation domain 170 266 7.5E-16 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 SUPERFAMILY SSF55031 170 271 1.7E-21 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 Gene3D G3DSA:3.30.70.360 171 270 1.0E-25 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 SUPERFAMILY SSF53187 276 355 7.11E-43 T 17-03-2017 SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 SUPERFAMILY SSF53187 14 182 7.11E-43 T 17-03-2017 SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 Gene3D G3DSA:3.40.630.10 277 354 6.5E-44 T 17-03-2017 SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 Gene3D G3DSA:3.40.630.10 13 170 6.5E-44 T 17-03-2017 SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 Pfam PF01546 Peptidase family M20/M25/M40 69 350 8.4E-21 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS34060 be1701b44d349e06b762f00dfb986ee5 356 TIGRFAM TIGR01900 dapE-gram_pos: succinyl-diaminopimelate desuccinylase 11 355 5.9E-161 T 17-03-2017 IPR010174 Succinyl-diaminopimelate desuccinylase, DapE GO:0009014|GO:0009089 KEGG: 00300+3.5.1.18 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 44 67 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 Pfam PF00069 Protein kinase domain 39 293 6.4E-47 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 Gene3D G3DSA:1.10.510.10 402 465 1.3E-49 T 17-03-2017 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 Gene3D G3DSA:1.10.510.10 127 301 1.3E-49 T 17-03-2017 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 SMART SM00220 38 300 1.1E-58 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 Gene3D G3DSA:3.30.200.20 34 121 8.5E-25 T 17-03-2017 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 161 173 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS28420 a0d7994b5b611efb7ac49529ae75043f 524 SUPERFAMILY SSF56112 36 297 3.51E-73 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 Pfam PF00781 Diacylglycerol kinase catalytic domain 197 318 1.0E-14 T 17-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 SUPERFAMILY SSF48317 17 175 5.1E-38 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 Gene3D G3DSA:1.20.144.10 4 182 5.6E-32 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 SMART SM00046 196 319 5.0E-4 T 17-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 SUPERFAMILY SSF111331 196 493 1.53E-45 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 Pfam PF01569 PAP2 superfamily 63 174 2.5E-20 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS07395 b389d31fe7f7fb9f583a073dd9c660d9 519 SMART SM00014 60 169 1.9E-20 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS01945 2e5e1ab2d03bd145b98f242474741e2f 538 SUPERFAMILY SSF53850 32 520 4.34E-106 T 17-03-2017 SHXM_RS01945 2e5e1ab2d03bd145b98f242474741e2f 538 Gene3D G3DSA:3.90.76.10 43 195 5.6E-37 T 17-03-2017 SHXM_RS01945 2e5e1ab2d03bd145b98f242474741e2f 538 PIRSF PIRSF002741 5 533 1.9E-69 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS01945 2e5e1ab2d03bd145b98f242474741e2f 538 Gene3D G3DSA:3.10.105.10 302 504 1.7E-35 T 17-03-2017 SHXM_RS01945 2e5e1ab2d03bd145b98f242474741e2f 538 Gene3D G3DSA:3.40.190.10 196 301 1.9E-26 T 17-03-2017 SHXM_RS01945 2e5e1ab2d03bd145b98f242474741e2f 538 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 77 433 2.6E-71 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 Gene3D G3DSA:1.10.10.60 6 44 1.0E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 SUPERFAMILY SSF48498 87 195 2.12E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 61 5.2E-18 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 Gene3D G3DSA:1.10.357.10 67 197 9.4E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 Gene3D G3DSA:1.10.10.60 45 66 4.1E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 15 28 2.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 59 2.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS18655 f8d963f668730d69f0475bfae62940ee 206 SUPERFAMILY SSF46689 4 78 4.21E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 171 190 3.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 98 109 3.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 159 3.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 Pfam PF00106 short chain dehydrogenase 28 211 5.8E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 SUPERFAMILY SSF51735 27 269 1.24E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 158 186 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 192 209 1.4E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 190 1.4E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 28 45 1.4E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 161 1.4E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 98 109 1.4E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 27 207 0.0017 T 17-03-2017 SHXM_RS03395 57d2749c6e8f5b72b2b35901d9fc7bbf 272 Gene3D G3DSA:3.40.50.720 27 243 5.9E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 1.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 1.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 1.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 1.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 Pfam PF00106 short chain dehydrogenase 10 192 4.4E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 SUPERFAMILY SSF51735 5 241 4.18E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 4.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 4.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 4.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04010 27fc7ee09fd546c16d7e477bd9839abb 284 Gene3D G3DSA:3.40.50.720 7 249 1.5E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10200 83677d62e53c7c934fb3f884c243b5d1 382 SUPERFAMILY SSF53098 110 352 3.94E-24 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10200 83677d62e53c7c934fb3f884c243b5d1 382 Pfam PF13006 Insertion element 4 transposase N-terminal 1 95 6.6E-31 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS10200 83677d62e53c7c934fb3f884c243b5d1 382 Pfam PF01609 Transposase DDE domain 112 338 1.3E-18 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 TIGRFAM TIGR00218 manA: mannose-6-phosphate isomerase, class I 4 385 2.7E-76 T 17-03-2017 IPR001250 Mannose-6-phosphate isomerase, type I GO:0004476|GO:0005975|GO:0008270 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PIRSF PIRSF001480 1 398 3.7E-99 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 ProSitePatterns PS00965 Phosphomannose isomerase type I signature 1. 125 133 - T 17-03-2017 IPR018050 Phosphomannose isomerase, type I, conserved site GO:0004476 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 Gene3D G3DSA:1.10.441.10 140 238 6.3E-24 T 17-03-2017 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 Gene3D G3DSA:1.10.441.10 281 294 6.3E-24 T 17-03-2017 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 Pfam PF01238 Phosphomannose isomerase type I 3 360 1.1E-69 T 17-03-2017 IPR001250 Mannose-6-phosphate isomerase, type I GO:0004476|GO:0005975|GO:0008270 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 Gene3D G3DSA:2.60.120.10 295 396 1.5E-16 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 262 281 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 4 22 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 31 46 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 125 148 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 281 300 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 80 101 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 243 262 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 PRINTS PR00714 Phosphomannose isomerase type I signature 227 242 2.8E-63 T 17-03-2017 IPR016305 Mannose-6-phosphate isomerase GO:0004476|GO:0009298 KEGG: 00051+5.3.1.8|KEGG: 00520+5.3.1.8|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5659|MetaCyc: PWY-6992|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882|Reactome: R-HSA-4043916|Reactome: R-HSA-446205 SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 Gene3D G3DSA:2.60.120.10 6 139 6.9E-62 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 Gene3D G3DSA:2.60.120.10 245 280 6.9E-62 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS24170 84cbdc748d6ae5e339c2df101b8b29b8 398 SUPERFAMILY SSF51182 2 395 7.56E-98 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS00245 b7004eba1aedce7d70f6ce1b34aa74ad 157 SUPERFAMILY SSF88659 93 142 2.4E-6 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00245 b7004eba1aedce7d70f6ce1b34aa74ad 157 Gene3D G3DSA:1.10.10.10 96 132 1.2E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 15 28 1.9E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 36 59 1.9E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 56 8.0E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 Gene3D G3DSA:1.10.10.60 2 53 5.9E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 SUPERFAMILY SSF46689 2 59 1.75E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 Gene3D G3DSA:1.10.357.10 54 185 8.9E-15 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47510 0e159d82b96b1565cee939c10dde072d 190 ProSitePatterns PS01081 TetR-type HTH domain signature. 27 58 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS13640 ac4dcd209ca45637b6eddb260f48556f 656 Gene3D G3DSA:3.40.50.1110 153 339 3.6E-20 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13640 ac4dcd209ca45637b6eddb260f48556f 656 Gene3D G3DSA:3.40.50.1110 471 654 1.7E-21 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13640 ac4dcd209ca45637b6eddb260f48556f 656 SUPERFAMILY SSF52266 464 654 3.97E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13640 ac4dcd209ca45637b6eddb260f48556f 656 SUPERFAMILY SSF52266 153 338 2.11E-22 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13640 ac4dcd209ca45637b6eddb260f48556f 656 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 473 640 4.0E-19 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13640 ac4dcd209ca45637b6eddb260f48556f 656 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 155 325 2.3E-19 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS25860 88feb0f167da25fdf08da300bc0530e5 433 TIGRFAM TIGR00260 thrC: threonine synthase 76 406 6.0E-81 T 17-03-2017 IPR004450 Threonine synthase-like SHXM_RS25860 88feb0f167da25fdf08da300bc0530e5 433 Gene3D G3DSA:3.40.50.1100 131 215 4.9E-28 T 17-03-2017 SHXM_RS25860 88feb0f167da25fdf08da300bc0530e5 433 Gene3D G3DSA:3.40.50.1100 216 412 8.8E-35 T 17-03-2017 SHXM_RS25860 88feb0f167da25fdf08da300bc0530e5 433 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 95 401 2.6E-62 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS25860 88feb0f167da25fdf08da300bc0530e5 433 SUPERFAMILY SSF53686 17 415 6.8E-88 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS03290 79cee8b42132a3d47b8897c3c9b470a9 168 Gene3D G3DSA:1.20.120.450 1 166 1.0E-70 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS03290 79cee8b42132a3d47b8897c3c9b470a9 168 SUPERFAMILY SSF109854 5 165 2.29E-34 T 17-03-2017 SHXM_RS03290 79cee8b42132a3d47b8897c3c9b470a9 168 Pfam PF04978 Protein of unknown function (DUF664) 7 165 1.0E-22 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.47.10 50 300 1.8E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF55048 1639 1703 8.5E-12 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF08659 KR domain 2323 2491 1.2E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.47.10 1011 1262 2.0E-93 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF51735 2319 2563 1.47E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 ProSitePatterns PS00012 Phosphopantetheine attachment site. 945 960 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF47336 2574 2655 1.15E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF52151 1515 1635 1.23E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF52151 1697 1805 1.23E-68 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:1.10.1200.10 917 990 2.6E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:1.10.1200.10 2575 2648 4.0E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF14765 Polyketide synthase dehydratase 1879 2144 1.3E-55 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.366.10 555 673 5.8E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.366.10 738 845 5.8E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF55048 678 738 2.75E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2602 2617 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 416 528 1.8E-20 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1376 1484 6.6E-13 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 52 287 7.3E-72 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1009 1250 4.2E-85 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF53901 1005 1363 2.23E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1163 1179 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.30.70.250 1639 1703 3.7E-7 T 17-03-2017 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF53901 440 461 5.47E-81 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF53901 48 406 5.47E-81 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.366.10 1704 1824 1.8E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.366.10 1513 1636 1.8E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.50.720 2322 2524 6.5E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1258 1373 1.6E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 295 413 3.7E-38 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF52151 740 836 1.1E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF52151 555 679 1.1E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00826 1879 2040 4.0E-70 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF47336 913 1024 4.97E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 559 845 9.9E-113 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1518 1811 5.2E-115 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00825 Beta-ketoacyl synthase 53 466 1.6E-177 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00825 Beta-ketoacyl synthase 1011 1426 1.4E-213 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF00550 Phosphopantetheine attachment site 2578 2643 3.0E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF00550 Phosphopantetheine attachment site 928 986 2.8E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2323 2493 2.3E-52 T 17-03-2017 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF00698 Acyl transferase domain 557 864 2.7E-82 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Pfam PF00698 Acyl transferase domain 1517 1818 8.6E-50 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM01294 2576 2643 2.8E-6 T 17-03-2017 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00823 Phosphopantetheine attachment site 918 990 3.0E-23 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SMART SM00823 Phosphopantetheine attachment site 2575 2647 9.6E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.47.10 1263 1425 3.7E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 Gene3D G3DSA:3.40.47.10 301 466 1.2E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46775 bda59ea2b573a969543d1e0a7d3acb7e 2746 SUPERFAMILY SSF51735 2149 2311 1.1E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 Gene3D G3DSA:1.10.10.10 21 152 5.5E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 Pfam PF01047 MarR family 49 100 2.4E-16 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 SMART SM00347 36 136 2.9E-22 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 96 112 2.2E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 77 92 2.2E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 126 146 2.2E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 60 76 2.2E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42235 ab5120905950e0d418b4a8d11a2d6a55 160 SUPERFAMILY SSF46785 20 150 1.85E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30160 7fe077d6f38232420eff006baaa06fdb 408 Pfam PF12704 MacB-like periplasmic core domain 41 247 1.3E-20 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS30160 7fe077d6f38232420eff006baaa06fdb 408 Pfam PF02687 FtsX-like permease family 289 399 8.1E-19 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS12745 a1bfb87c963cbb56650f37b4e87e4c74 316 SUPERFAMILY SSF102198 109 315 1.83E-16 T 17-03-2017 SHXM_RS12745 a1bfb87c963cbb56650f37b4e87e4c74 316 Gene3D G3DSA:3.50.30.50 112 315 5.1E-20 T 17-03-2017 SHXM_RS12745 a1bfb87c963cbb56650f37b4e87e4c74 316 Pfam PF04199 Putative cyclase 96 244 1.2E-17 T 17-03-2017 IPR007325 Kynurenine formamidase GO:0004061|GO:0019441 KEGG: 00380+3.5.1.9|KEGG: 00630+3.5.1.9|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-7717|MetaCyc: PWY-7733|MetaCyc: PWY-7734 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.90.1170.50 9 126 1.4E-34 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS45480 63b22589d2e06344a583be764b888888 716 SUPERFAMILY SSF54665 10 144 7.72E-35 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.30.365.10 178 280 3.0E-35 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.30.365.10 441 534 2.2E-21 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 28 138 4.9E-21 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS45480 63b22589d2e06344a583be764b888888 716 SUPERFAMILY SSF56003 161 705 3.4E-151 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.30.365.10 357 440 1.1E-53 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.30.365.10 563 705 1.1E-53 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.30.365.10 127 177 2.8E-8 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Gene3D G3DSA:3.30.365.10 284 307 2.8E-8 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 162 534 2.6E-84 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 560 647 1.2E-18 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS45480 63b22589d2e06344a583be764b888888 716 SMART SM01008 28 139 2.4E-36 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 Pfam PF00106 short chain dehydrogenase 18 201 1.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 SUPERFAMILY SSF51735 14 270 5.07E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 Gene3D G3DSA:3.40.50.720 16 242 6.3E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 161 180 5.6E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 89 100 5.6E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 141 149 5.6E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 148 176 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 17 196 1.9E-4 T 17-03-2017 SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 18 35 7.8E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 89 100 7.8E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 180 7.8E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33720 df004c19cf1b159624df671285e7a790 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 135 151 7.8E-17 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 SUPERFAMILY SSF46785 31 99 9.36E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 Gene3D G3DSA:1.10.10.10 29 101 1.2E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 SMART SM00346 31 118 4.0E-22 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 Gene3D G3DSA:3.30.450.40 105 270 1.0E-61 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 SUPERFAMILY SSF55781 88 270 2.22E-51 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 Pfam PF01614 Bacterial transcriptional regulator 146 267 3.1E-32 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS38985 b4cd8d00d033bcfb0ae76b536aeab4c8 276 Pfam PF09339 IclR helix-turn-helix domain 33 84 1.4E-17 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS47935 334d1cd1d25b5cc30054104c59bd0061 185 Gene3D G3DSA:1.10.10.60 11 59 7.5E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47935 334d1cd1d25b5cc30054104c59bd0061 185 SUPERFAMILY SSF46689 4 73 2.51E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47935 334d1cd1d25b5cc30054104c59bd0061 185 SUPERFAMILY SSF48498 80 184 3.07E-21 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47935 334d1cd1d25b5cc30054104c59bd0061 185 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 60 1.8E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47935 334d1cd1d25b5cc30054104c59bd0061 185 Gene3D G3DSA:1.10.357.10 60 184 3.1E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 PIRSF PIRSF001394 28 555 8.5E-226 T 17-03-2017 IPR011167 Iron-dependent fumarate hydratase GO:0004333|GO:0006091 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 TIGRFAM TIGR00723 ttdB_fumA_fumB: hydrolyase, tartrate beta subunit/fumarate domain protein, Fe-S type 377 540 1.3E-56 T 17-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 TIGRFAM TIGR00722 ttdA_fumA_fumB: hydrolyase, tartrate alpha subunit/fumarate domain protein, Fe-S type 53 325 1.6E-33 T 17-03-2017 IPR004646 Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain GO:0016829 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 Gene3D G3DSA:3.20.130.10 361 540 8.1E-73 T 17-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 SUPERFAMILY SSF117457 365 540 3.66E-61 T 17-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 ProSitePatterns PS00163 Fumarate lyases signature. 460 469 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 Pfam PF05681 Fumarate hydratase (Fumerase) 48 324 1.6E-89 T 17-03-2017 IPR004646 Fe-S hydro-lyase, tartrate dehydratase alpha-type, catalytic domain GO:0016829 SHXM_RS33630 554967ac58f43af4e6c936836f16b6c7 559 Pfam PF05683 Fumarase C-terminus 330 541 2.6E-91 T 17-03-2017 IPR004647 Fe-S hydro-lyase, tartrate dehydratase beta-type, catalytic domain GO:0016836 SHXM_RS43055 45a9dd77997c5c348f635d1df6175891 322 PIRSF PIRSF006232 20 303 1.1E-81 T 17-03-2017 IPR012093 Pirin SHXM_RS43055 45a9dd77997c5c348f635d1df6175891 322 SUPERFAMILY SSF51182 36 304 2.36E-69 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS43055 45a9dd77997c5c348f635d1df6175891 322 Gene3D G3DSA:2.60.120.10 24 267 7.0E-59 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS43055 45a9dd77997c5c348f635d1df6175891 322 Pfam PF02678 Pirin 45 141 8.0E-25 T 17-03-2017 IPR003829 Pirin, N-terminal domain SHXM_RS43055 45a9dd77997c5c348f635d1df6175891 322 Pfam PF05726 Pirin C-terminal cupin domain 194 292 5.3E-22 T 17-03-2017 IPR008778 Pirin, C-terminal domain SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 SUPERFAMILY SSF46955 11 126 2.16E-29 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 12 23 2.4E-5 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 23 36 2.4E-5 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 SMART SM00422 11 81 6.6E-21 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 ProSitePatterns PS00552 MerR-type HTH domain signature. 14 36 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 Pfam PF13411 MerR HTH family regulatory protein 12 77 1.6E-18 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44240 85e87882923467f0c9db0dd20b869a57 140 Gene3D G3DSA:1.10.1660.10 12 125 3.6E-32 T 17-03-2017 SHXM_RS36785 c047738281520dc798d73a0d2f7cab8f 317 Gene3D G3DSA:1.10.3720.10 32 307 8.4E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36785 c047738281520dc798d73a0d2f7cab8f 317 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 111 303 7.2E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36785 c047738281520dc798d73a0d2f7cab8f 317 SUPERFAMILY SSF161098 32 310 1.24E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 Pfam PF12697 Alpha/beta hydrolase family 4 234 2.6E-16 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 SUPERFAMILY SSF53474 3 242 2.26E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 Gene3D G3DSA:3.40.50.1820 3 245 1.0E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00111 Alpha/beta hydrolase fold signature 85 98 2.1E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00111 Alpha/beta hydrolase fold signature 25 40 2.1E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00111 Alpha/beta hydrolase fold signature 71 84 2.1E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00412 Epoxide hydrolase signature 25 40 2.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00412 Epoxide hydrolase signature 85 98 2.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00412 Epoxide hydrolase signature 220 242 2.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09945 02e074dfdebf28f84af07cfbdaac072c 254 PRINTS PR00412 Epoxide hydrolase signature 71 84 2.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS04375 1bfe772f264a374370ec16162f2ef707 415 Gene3D G3DSA:3.90.1150.10 281 395 8.1E-22 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS04375 1bfe772f264a374370ec16162f2ef707 415 SUPERFAMILY SSF53383 42 397 1.05E-112 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS04375 1bfe772f264a374370ec16162f2ef707 415 Pfam PF00155 Aminotransferase class I and II 49 390 1.8E-74 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS04375 1bfe772f264a374370ec16162f2ef707 415 Gene3D G3DSA:3.40.640.10 63 280 3.1E-93 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS04375 1bfe772f264a374370ec16162f2ef707 415 TIGRFAM TIGR01821 5aminolev_synth: 5-aminolevulinic acid synthase 16 398 1.0E-162 T 17-03-2017 IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase GO:0003870|GO:0030170|GO:0033014 KEGG: 00260+2.3.1.37|KEGG: 00860+2.3.1.37|MetaCyc: PWY-5189|MetaCyc: PWY-7536|Reactome: R-HSA-189451 SHXM_RS22375 d78cb0a352ad7fb7ca05bb86cae969d6 389 SUPERFAMILY SSF51569 54 336 1.78E-14 T 17-03-2017 SHXM_RS22375 d78cb0a352ad7fb7ca05bb86cae969d6 389 Pfam PF06187 Protein of unknown function (DUF993) 4 387 2.6E-184 T 17-03-2017 IPR009334 Protein of unknown function DUF993 SHXM_RS22375 d78cb0a352ad7fb7ca05bb86cae969d6 389 Gene3D G3DSA:3.20.20.70 56 335 3.3E-7 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS23085 ea5aa30e4b9547c699e2d5374c813781 135 SUPERFAMILY SSF75169 10 130 8.41E-11 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS23085 ea5aa30e4b9547c699e2d5374c813781 135 Gene3D G3DSA:3.40.1260.10 10 130 1.1E-10 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS23085 ea5aa30e4b9547c699e2d5374c813781 135 Pfam PF02635 DsrE/DsrF-like family 15 111 3.7E-6 T 17-03-2017 IPR003787 Sulphur relay, DsrE/F-like protein SHXM_RS17340 fe25540065d58735c75afbecb44c17b3 464 Pfam PF01523 Putative modulator of DNA gyrase 21 326 2.4E-32 T 17-03-2017 IPR002510 Metalloprotease TldD/PmbA GO:0006508|GO:0008237 SHXM_RS17340 fe25540065d58735c75afbecb44c17b3 464 SUPERFAMILY SSF111283 6 457 1.7E-65 T 17-03-2017 SHXM_RS30510 ec21e609674ee3b48630c10b7d5188bf 305 Gene3D G3DSA:3.40.710.10 46 305 3.3E-78 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS30510 ec21e609674ee3b48630c10b7d5188bf 305 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 165 178 1.2E-13 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS30510 ec21e609674ee3b48630c10b7d5188bf 305 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 132 149 1.2E-13 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS30510 ec21e609674ee3b48630c10b7d5188bf 305 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 77 88 1.2E-13 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS30510 ec21e609674ee3b48630c10b7d5188bf 305 SUPERFAMILY SSF56601 48 303 2.69E-57 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS30510 ec21e609674ee3b48630c10b7d5188bf 305 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 43 284 5.9E-42 T 17-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 Gene3D G3DSA:3.40.50.1240 5 253 2.9E-87 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 SMART SM00855 7 193 2.3E-22 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 Hamap MF_01039 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [gpmA]. 5 234 42.173 T 17-03-2017 IPR005952 Phosphoglycerate mutase 1 GO:0004619|GO:0006096|GO:0016868 KEGG: 00010+5.4.2.11|KEGG: 00260+5.4.2.11|KEGG: 00680+5.4.2.11|MetaCyc: PWY-1622|MetaCyc: PWY-5484 SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 SUPERFAMILY SSF53254 6 224 5.14E-70 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 ProSitePatterns PS00175 Phosphoglycerate mutase family phosphohistidine signature. 10 19 - T 17-03-2017 IPR001345 Phosphoglycerate/bisphosphoglycerate mutase, active site GO:0003824|GO:0008152 SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 8 133 4.1E-26 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS26125 ced8b01bff9d44e2d797d2e96ea154d6 253 TIGRFAM TIGR01258 pgm_1: phosphoglycerate mutase 1 family 7 251 3.0E-111 T 17-03-2017 IPR005952 Phosphoglycerate mutase 1 GO:0004619|GO:0006096|GO:0016868 KEGG: 00010+5.4.2.11|KEGG: 00260+5.4.2.11|KEGG: 00680+5.4.2.11|MetaCyc: PWY-1622|MetaCyc: PWY-5484 SHXM_RS40975 3294f481f2c2f35bb27784b69db1776e 270 Gene3D G3DSA:1.10.3720.10 4 260 3.5E-41 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40975 3294f481f2c2f35bb27784b69db1776e 270 SUPERFAMILY SSF161098 4 268 1.5E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40975 3294f481f2c2f35bb27784b69db1776e 270 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 101 264 4.3E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07320 2eebda153f7a07435e006d4fa0cc8159 382 TIGRFAM TIGR00312 cbiD: cobalamin biosynthesis protein CbiD 30 334 2.1E-51 T 17-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 SHXM_RS07320 2eebda153f7a07435e006d4fa0cc8159 382 Gene3D G3DSA:3.30.2110.10 26 198 1.1E-59 T 17-03-2017 SHXM_RS07320 2eebda153f7a07435e006d4fa0cc8159 382 Pfam PF01888 CbiD 23 283 3.7E-89 T 17-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 SHXM_RS07320 2eebda153f7a07435e006d4fa0cc8159 382 PIRSF PIRSF026782 19 379 8.7E-127 T 17-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 SHXM_RS07320 2eebda153f7a07435e006d4fa0cc8159 382 SUPERFAMILY SSF111342 16 301 2.48E-82 T 17-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 SHXM_RS07320 2eebda153f7a07435e006d4fa0cc8159 382 Hamap MF_00787 Cobalt-precorrin-5B C(1)-methyltransferase [cbiD]. 23 374 27.567 T 17-03-2017 IPR002748 Cobalt-precorrin-5B C(1)-methyltransferase CbiD GO:0008168|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.195|MetaCyc: PWY-2201|MetaCyc: PWY-7377 SHXM_RS13235 32813ec58d944a914e5d7cbd59de3ffa 294 SUPERFAMILY SSF55729 131 273 2.74E-22 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS13235 32813ec58d944a914e5d7cbd59de3ffa 294 Gene3D G3DSA:3.40.630.30 149 274 8.0E-22 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS13235 32813ec58d944a914e5d7cbd59de3ffa 294 Pfam PF00583 Acetyltransferase (GNAT) family 194 270 1.5E-10 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS43005 ca609ae479b4f55ad72395f17b4fff8d 496 Pfam PF01740 STAS domain 408 479 2.2E-8 T 17-03-2017 IPR002645 STAS domain SHXM_RS43005 ca609ae479b4f55ad72395f17b4fff8d 496 Gene3D G3DSA:3.30.750.24 408 480 1.2E-9 T 17-03-2017 IPR002645 STAS domain SHXM_RS43005 ca609ae479b4f55ad72395f17b4fff8d 496 SUPERFAMILY SSF52091 406 481 3.34E-12 T 17-03-2017 IPR002645 STAS domain SHXM_RS43005 ca609ae479b4f55ad72395f17b4fff8d 496 Pfam PF00916 Sulfate permease family 171 364 2.5E-26 T 17-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SHXM_RS43005 ca609ae479b4f55ad72395f17b4fff8d 496 Pfam PF00916 Sulfate permease family 23 149 8.3E-21 T 17-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SHXM_RS48780 5f97aaaf392c986462a0fac0c5fc5e63 236 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 73 1.7E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48780 5f97aaaf392c986462a0fac0c5fc5e63 236 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 91 233 7.1E-15 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS48780 5f97aaaf392c986462a0fac0c5fc5e63 236 SUPERFAMILY SSF46689 19 82 1.25E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48780 5f97aaaf392c986462a0fac0c5fc5e63 236 Gene3D G3DSA:1.10.10.60 11 78 4.2E-24 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48780 5f97aaaf392c986462a0fac0c5fc5e63 236 SUPERFAMILY SSF48498 91 232 1.33E-19 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS48780 5f97aaaf392c986462a0fac0c5fc5e63 236 Gene3D G3DSA:1.10.357.10 79 233 6.7E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS01435 2c84db38c92ee1df6851bbe505e4b6a8 330 ProSitePatterns PS01045 Squalene and phytoene synthases signature 2. 174 199 - T 17-03-2017 IPR019845 Squalene/phytoene synthase, conserved site GO:0016765 Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS01435 2c84db38c92ee1df6851bbe505e4b6a8 330 Pfam PF00494 Squalene/phytoene synthase 29 291 1.4E-60 T 17-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 SHXM_RS01435 2c84db38c92ee1df6851bbe505e4b6a8 330 ProSitePatterns PS01044 Squalene and phytoene synthases signature 1. 142 157 - T 17-03-2017 IPR019845 Squalene/phytoene synthase, conserved site GO:0016765 Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS01435 2c84db38c92ee1df6851bbe505e4b6a8 330 Gene3D G3DSA:1.10.600.10 15 306 6.7E-72 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS01435 2c84db38c92ee1df6851bbe505e4b6a8 330 SUPERFAMILY SSF48576 19 304 6.71E-70 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 Gene3D G3DSA:3.30.200.20 101 154 1.5E-8 T 17-03-2017 SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 SUPERFAMILY SSF56112 507 599 3.36E-20 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 SUPERFAMILY SSF56112 100 190 3.36E-20 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 Gene3D G3DSA:1.10.510.10 155 195 1.7E-16 T 17-03-2017 SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 Gene3D G3DSA:1.10.510.10 495 600 1.7E-16 T 17-03-2017 SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 Pfam PF00069 Protein kinase domain 104 185 1.8E-7 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31625 55aae3beee1dc9c855289639ef6b4ee6 943 SMART SM00220 23 600 8.5E-9 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 9 134 4.2E-16 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 148 225 1.0E-18 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 SUPERFAMILY SSF51735 6 165 1.25E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 Gene3D G3DSA:3.30.360.10 376 445 3.3E-57 T 17-03-2017 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 Gene3D G3DSA:3.30.360.10 151 223 3.3E-57 T 17-03-2017 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 Gene3D G3DSA:3.30.360.10 280 328 3.3E-57 T 17-03-2017 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 SUPERFAMILY SSF55347 139 224 4.91E-29 T 17-03-2017 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 SUPERFAMILY SSF55347 279 341 4.91E-29 T 17-03-2017 SHXM_RS06625 d4af73c7bd996000cfc83f3520b3dd88 452 Gene3D G3DSA:3.40.50.720 5 150 1.5E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25610 3299be7cedf34c3ba35e7feb5da6934f 532 Gene3D G3DSA:3.90.226.10 27 266 3.7E-64 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS25610 3299be7cedf34c3ba35e7feb5da6934f 532 Gene3D G3DSA:3.90.226.10 275 521 1.6E-76 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS25610 3299be7cedf34c3ba35e7feb5da6934f 532 Pfam PF01039 Carboxyl transferase domain 48 520 2.2E-135 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS25610 3299be7cedf34c3ba35e7feb5da6934f 532 SUPERFAMILY SSF52096 23 263 1.44E-63 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS25610 3299be7cedf34c3ba35e7feb5da6934f 532 SUPERFAMILY SSF52096 232 512 4.31E-75 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 Gene3D G3DSA:3.40.366.10 1 108 1.9E-65 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 Gene3D G3DSA:3.40.366.10 174 259 1.9E-65 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 Pfam PF00698 Acyl transferase domain 1 255 1.5E-46 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1 257 2.0E-93 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 SUPERFAMILY SSF52151 175 259 3.14E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 SUPERFAMILY SSF52151 1 114 3.14E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 SUPERFAMILY SSF55048 113 174 4.97E-15 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05330 30fbee989c962a0db82ed7005d1ab3f3 259 Gene3D G3DSA:3.30.70.250 113 173 1.1E-8 T 17-03-2017 SHXM_RS33005 0871d13288dffb0997934b7dd0b83913 293 Pfam PF13354 Beta-lactamase enzyme family 28 261 1.1E-49 T 17-03-2017 SHXM_RS33005 0871d13288dffb0997934b7dd0b83913 293 Gene3D G3DSA:3.40.710.10 2 292 2.2E-56 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS33005 0871d13288dffb0997934b7dd0b83913 293 SUPERFAMILY SSF56601 2 147 8.88E-41 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS33005 0871d13288dffb0997934b7dd0b83913 293 SUPERFAMILY SSF56601 178 283 8.88E-41 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 TIGRFAM TIGR00754 bfr: bacterioferritin 1 156 1.2E-61 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 Pfam PF00210 Ferritin-like domain 9 143 4.3E-30 T 17-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 23 43 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 44 64 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 128 149 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 3 22 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 86 106 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 65 85 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PRINTS PR00601 Bacterioferritin signature 107 127 3.1E-53 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 PIRSF PIRSF002560 1 157 1.0E-62 T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 SUPERFAMILY SSF47240 1 156 3.48E-44 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 ProSitePatterns PS00549 Bacterioferritin signature. 1 19 - T 17-03-2017 IPR002024 Bacterioferritin GO:0006826|GO:0006879|GO:0008199 SHXM_RS18730 6abecf2862a121ee71d800e8861fb5a5 171 Gene3D G3DSA:1.20.1260.10 1 156 6.3E-52 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS25425 8f29807258de64fcbb9f1f7ccdf43699 95 SMART SM00830 24 92 6.3E-6 T 17-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS25425 8f29807258de64fcbb9f1f7ccdf43699 95 Gene3D G3DSA:1.20.59.10 8 78 1.1E-12 T 17-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS25425 8f29807258de64fcbb9f1f7ccdf43699 95 SUPERFAMILY SSF48600 21 80 8.7E-12 T 17-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS25425 8f29807258de64fcbb9f1f7ccdf43699 95 Pfam PF01817 Chorismate mutase type II 24 77 1.2E-9 T 17-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS25425 8f29807258de64fcbb9f1f7ccdf43699 95 TIGRFAM TIGR01808 CM_M_hiGC-arch: chorismate mutase 20 93 1.4E-18 T 17-03-2017 IPR010958 Chorismate mutase, high GC Gram-positive bacteria/archaeal SHXM_RS08520 1b443557b54642099adb72f4c4ef2db2 289 SMART SM00530 15 70 6.4E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS08520 1b443557b54642099adb72f4c4ef2db2 289 SUPERFAMILY SSF47413 8 65 2.09E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS08520 1b443557b54642099adb72f4c4ef2db2 289 Pfam PF13560 Helix-turn-helix domain 12 73 9.6E-15 T 17-03-2017 SHXM_RS08520 1b443557b54642099adb72f4c4ef2db2 289 Gene3D G3DSA:1.10.260.40 7 66 1.8E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 Gene3D G3DSA:3.40.50.2300 2 123 1.4E-40 T 17-03-2017 SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 SUPERFAMILY SSF52172 4 177 1.99E-43 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 Gene3D G3DSA:1.10.10.10 124 222 5.1E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 221 1.8E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 SMART SM00448 3 113 5.6E-45 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 SMART SM00862 146 222 3.3E-22 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS24120 c269e107a6d4aa28f451884eb7b4748c 225 Pfam PF00072 Response regulator receiver domain 5 114 7.2E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS11640 0441632217595b5caf9cab3ae51a0062 370 SUPERFAMILY SSF46689 71 151 8.78E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11640 0441632217595b5caf9cab3ae51a0062 370 Pfam PF13683 Integrase core domain 264 324 1.6E-11 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS11640 0441632217595b5caf9cab3ae51a0062 370 Gene3D G3DSA:3.30.420.10 167 324 2.8E-17 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS11640 0441632217595b5caf9cab3ae51a0062 370 SUPERFAMILY SSF53098 170 326 8.8E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS11640 0441632217595b5caf9cab3ae51a0062 370 Pfam PF13276 HTH-like domain 106 156 1.6E-8 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS16540 0633cc0e06a64bc7e2e144917d3655de 551 ProSitePatterns PS00018 EF-hand calcium-binding domain. 99 111 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS16540 0633cc0e06a64bc7e2e144917d3655de 551 ProSitePatterns PS00435 Peroxidases proximal heme-ligand signature. 289 299 - T 17-03-2017 IPR019793 Peroxidases heam-ligand binding site Reactome: R-HSA-2408557 SHXM_RS16540 0633cc0e06a64bc7e2e144917d3655de 551 Pfam PF03824 High-affinity nickel-transport protein 286 525 3.9E-11 T 17-03-2017 IPR011541 Nickel/cobalt transporter, high-affinity GO:0015099|GO:0016021|GO:0035444|GO:0046872 SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 SUPERFAMILY SSF52540 256 356 9.91E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 SUPERFAMILY SSF52540 1 227 9.91E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 Gene3D G3DSA:3.40.50.300 251 355 1.1E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 Gene3D G3DSA:3.40.50.300 1 166 1.1E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 TIGRFAM TIGR00611 recf: DNA replication and repair protein RecF 1 369 1.2E-126 T 17-03-2017 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 Hamap MF_00365 DNA replication and repair protein RecF [recF]. 1 380 96.811 T 17-03-2017 IPR001238 DNA-binding, RecF GO:0003697|GO:0005524|GO:0006281 SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 Pfam PF02463 RecF/RecN/SMC N terminal domain 3 357 2.5E-19 T 17-03-2017 IPR003395 RecF/RecN/SMC, N-terminal SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 ProSitePatterns PS00617 RecF protein signature 1. 117 137 - T 17-03-2017 IPR018078 DNA-binding, RecF, conserved site GO:0003697|GO:0005524|GO:0006281 SHXM_RS28140 738406d5bb47c3e869423a1c4548bd3b 380 ProSitePatterns PS00618 RecF protein signature 2. 323 341 - T 17-03-2017 IPR018078 DNA-binding, RecF, conserved site GO:0003697|GO:0005524|GO:0006281 SHXM_RS18800 206dd05ed9e15fbe5ef060873a42c83b 435 Gene3D G3DSA:3.40.50.300 1 300 3.0E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18800 206dd05ed9e15fbe5ef060873a42c83b 435 Pfam PF02374 Anion-transporting ATPase 1 304 1.1E-28 T 17-03-2017 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 SHXM_RS18800 206dd05ed9e15fbe5ef060873a42c83b 435 SUPERFAMILY SSF52540 98 295 4.62E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18800 206dd05ed9e15fbe5ef060873a42c83b 435 SUPERFAMILY SSF52540 1 64 4.62E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13795 e662ef2982d99f2d0dc785ec4a0cbc03 51 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 2 41 1.0E-11 T 17-03-2017 SHXM_RS13795 e662ef2982d99f2d0dc785ec4a0cbc03 51 Gene3D G3DSA:3.40.50.720 2 43 2.8E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13795 e662ef2982d99f2d0dc785ec4a0cbc03 51 SUPERFAMILY SSF51735 2 44 2.22E-14 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41495 e5fcdaf10f3a06b535f6fc77bdab3941 488 Gene3D G3DSA:1.10.260.40 17 81 6.7E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41495 e5fcdaf10f3a06b535f6fc77bdab3941 488 Pfam PF13560 Helix-turn-helix domain 19 82 2.1E-13 T 17-03-2017 SHXM_RS41495 e5fcdaf10f3a06b535f6fc77bdab3941 488 SMART SM00530 23 79 1.1E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS41495 e5fcdaf10f3a06b535f6fc77bdab3941 488 SUPERFAMILY SSF47413 16 82 3.44E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 Pfam PF00128 Alpha amylase, catalytic domain 113 190 9.5E-9 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 SMART SM00642 102 498 1.4E-7 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 SUPERFAMILY SSF81296 2 77 7.4E-16 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 TIGRFAM TIGR02402 trehalose_TreZ: malto-oligosyltrehalose trehalohydrolase 3 534 5.2E-223 T 17-03-2017 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902 SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 SUPERFAMILY SSF51445 74 505 1.66E-108 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 Gene3D G3DSA:2.60.40.10 2 77 2.9E-24 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 Pfam PF11941 Domain of unknown function (DUF3459) 490 579 1.9E-8 T 17-03-2017 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 Gene3D G3DSA:3.20.20.80 93 427 4.2E-80 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 Gene3D G3DSA:3.20.20.80 465 504 4.2E-80 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38500 0f278c2ae2f6de19512c3e07011ee15f 586 PIRSF PIRSF006337 1 560 5.1E-222 T 17-03-2017 IPR012768 Malto-oligosyltrehalose trehalohydrolase GO:0004553|GO:0005992 KEGG: 00520+3.2.1.14|MetaCyc: PWY-2661|MetaCyc: PWY-6902 SHXM_RS49685 e9edef33b3cac10c5224add23069e131 271 SUPERFAMILY SSF161098 5 267 2.24E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49685 e9edef33b3cac10c5224add23069e131 271 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 85 263 1.0E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49685 e9edef33b3cac10c5224add23069e131 271 Gene3D G3DSA:1.10.3720.10 5 258 7.1E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48925 18e9e512ad39ead993c943f2efd54948 166 SMART SM00903 17 160 7.2E-49 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS48925 18e9e512ad39ead993c943f2efd54948 166 Pfam PF01613 Flavin reductase like domain 20 160 2.3E-31 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS48925 18e9e512ad39ead993c943f2efd54948 166 SUPERFAMILY SSF50475 4 163 4.91E-45 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS48925 18e9e512ad39ead993c943f2efd54948 166 Gene3D G3DSA:2.30.110.10 9 163 9.2E-49 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 Pfam PF00425 chorismate binding enzyme 228 480 4.1E-98 T 17-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 TIGRFAM TIGR00564 trpE_most: anthranilate synthase component I 25 489 1.6E-173 T 17-03-2017 IPR005256 Anthranilate synthase component I, PabB-like GO:0000162|GO:0004049 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 PRINTS PR00095 Anthranilate synthase component I signature 342 355 6.1E-24 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 PRINTS PR00095 Anthranilate synthase component I signature 328 341 6.1E-24 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 PRINTS PR00095 Anthranilate synthase component I signature 437 451 6.1E-24 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 PRINTS PR00095 Anthranilate synthase component I signature 422 436 6.1E-24 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 SUPERFAMILY SSF56322 14 488 4.45E-157 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 Pfam PF04715 Anthranilate synthase component I, N terminal region 26 169 4.5E-31 T 17-03-2017 IPR006805 Anthranilate synthase component I, N-terminal GO:0009058|GO:0016833 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS18335 fdae07eef13a6e2f5a8f5b62d87520a2 496 Gene3D G3DSA:3.60.120.10 13 489 1.1E-174 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS49020 75de6c782004949642f755631ccb2de1 103 Gene3D G3DSA:3.30.70.900 4 99 6.8E-30 T 17-03-2017 SHXM_RS49020 75de6c782004949642f755631ccb2de1 103 Pfam PF03992 Antibiotic biosynthesis monooxygenase 7 81 1.6E-17 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS49020 75de6c782004949642f755631ccb2de1 103 SUPERFAMILY SSF54909 7 100 1.94E-25 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 SUPERFAMILY SSF46785 24 94 4.08E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 Gene3D G3DSA:1.10.10.10 27 91 2.8E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 SUPERFAMILY SSF48008 95 230 9.68E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 Gene3D G3DSA:1.20.120.530 94 233 3.1E-35 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 SMART SM00895 100 222 2.1E-15 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 Pfam PF07729 FCD domain 100 221 4.7E-14 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 SMART SM00345 32 90 3.7E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS43705 dbe335b81fc420b8e691fbc4e0d90955 238 Pfam PF00392 Bacterial regulatory proteins, gntR family 28 90 1.6E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 Pfam PF00005 ABC transporter 372 521 4.1E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 SUPERFAMILY SSF52540 352 591 6.04E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 SUPERFAMILY SSF90123 34 342 7.19E-50 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 Gene3D G3DSA:3.40.50.300 356 586 2.3E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 SMART SM00382 381 567 5.6E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 Pfam PF00664 ABC transporter transmembrane region 45 313 4.0E-25 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS45170 a73236f92a08817c7eda3297193e173c 593 Gene3D G3DSA:1.20.1560.10 33 344 2.0E-48 T 17-03-2017 SHXM_RS11195 673ddf2f43d3cefb50c01a26ad2b1ce0 642 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 115 408 1.9E-31 T 17-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SHXM_RS11195 673ddf2f43d3cefb50c01a26ad2b1ce0 642 Gene3D G3DSA:3.20.20.80 51 433 2.9E-72 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS11195 673ddf2f43d3cefb50c01a26ad2b1ce0 642 SUPERFAMILY SSF51445 54 425 2.81E-45 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS11195 673ddf2f43d3cefb50c01a26ad2b1ce0 642 ProSitePatterns PS00659 Glycosyl hydrolases family 5 signature. 227 236 - T 17-03-2017 IPR018087 Glycoside hydrolase, family 5, conserved site GO:0004553|GO:0005975 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 ProSitePatterns PS01016 Glycoprotease family signature. 99 119 - T 17-03-2017 IPR017860 Peptidase M22, conserved site KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618|Reactome: R-HSA-6782315 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 158 179 3.2E-51 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 134 146 3.2E-51 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 8 21 3.2E-51 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 79 99 3.2E-51 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 271 280 3.2E-51 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 PRINTS PR00789 O-sialoglycoprotein endopeptidase (M22) metallo-protease family signature 100 119 3.2E-51 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 Pfam PF00814 Glycoprotease family 27 314 3.1E-98 T 17-03-2017 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 TIGRFAM TIGR00329 gcp_kae1: metallohydrolase, glycoprotease/Kae1 family 8 314 2.2E-99 T 17-03-2017 IPR017861 Kae1/TsaD family KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 TIGRFAM TIGR03723 T6A_TsaD_YgjD: tRNA threonylcarbamoyl adenosine modification protein TsaD 7 321 7.2E-127 T 17-03-2017 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 SUPERFAMILY SSF53067 6 316 8.63E-38 T 17-03-2017 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 Hamap MF_01445 tRNA N6-adenosine threonylcarbamoyltransferase [tsaD]. 5 340 61.739 T 17-03-2017 IPR022450 tRNA N6-adenosine threonylcarbamoyltransferase, TsaD GO:0002949|GO:0004222 KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31460 242d2000cbe32606ffefd998b219cafc 374 Gene3D G3DSA:3.30.420.40 6 163 1.9E-46 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 SUPERFAMILY SSF51905 174 395 5.88E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 Pfam PF13450 NAD(P)-binding Rossmann-like domain 180 214 1.7E-5 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 Pfam PF00743 Flavin-binding monooxygenase-like 218 377 2.6E-16 T 17-03-2017 IPR020946 Flavin monooxygenase-like GO:0004499|GO:0050660|GO:0050661|GO:0055114 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 177 199 3.3E-8 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 343 368 3.3E-8 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 302 311 3.3E-8 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 343 361 5.0E-5 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 178 197 5.0E-5 T 17-03-2017 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 SUPERFAMILY SSF51905 442 556 1.04E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 SUPERFAMILY SSF51905 341 373 1.04E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01035 2ccb435f80e735ef5909a1f11d2dc73e 583 Gene3D G3DSA:3.50.50.60 173 393 2.3E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45340 ca496c8f36d33f1f592d298cd7adc9f8 68 PRINTS PR00352 3Fe-4S ferredoxin signature 16 26 5.0E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS45340 ca496c8f36d33f1f592d298cd7adc9f8 68 PRINTS PR00352 3Fe-4S ferredoxin signature 5 16 5.0E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS45340 ca496c8f36d33f1f592d298cd7adc9f8 68 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 5.0E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS45340 ca496c8f36d33f1f592d298cd7adc9f8 68 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 6 62 2.2E-11 T 17-03-2017 SHXM_RS45340 ca496c8f36d33f1f592d298cd7adc9f8 68 SUPERFAMILY SSF54862 2 64 1.33E-12 T 17-03-2017 SHXM_RS45340 ca496c8f36d33f1f592d298cd7adc9f8 68 Gene3D G3DSA:3.30.70.20 1 66 3.8E-15 T 17-03-2017 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 SUPERFAMILY SSF49785 542 685 9.35E-45 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 ProSitePatterns PS00512 Alpha-galactosidase signature. 97 113 - T 17-03-2017 IPR000111 Glycoside hydrolase family 27/36, conserved site GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 265 284 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 54 73 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 92 107 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 169 186 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 200 218 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 133 154 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 PRINTS PR00740 Glycosyl hydrolase family 27 signature 286 307 5.4E-57 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 Gene3D G3DSA:3.20.20.70 52 324 3.1E-125 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 SMART SM00776 540 685 1.2E-76 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 Pfam PF16499 Alpha galactosidase A 59 395 3.5E-94 T 17-03-2017 IPR002241 Glycoside hydrolase, family 27 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 Pfam PF10633 NPCBM-associated, NEW3 domain of alpha-galactosidase 441 517 4.2E-20 T 17-03-2017 IPR018905 Alpha-galactosidase, NEW3 domain SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 Gene3D G3DSA:2.60.40.10 437 516 3.1E-8 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 Gene3D G3DSA:2.60.40.1180 325 417 2.0E-26 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 SUPERFAMILY SSF51011 332 417 1.06E-19 T 17-03-2017 SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 Pfam PF08305 NPCBM/NEW2 domain 543 684 1.9E-49 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS43175 fc95c23422db8b67c7c21cbfde797177 685 SUPERFAMILY SSF51445 52 331 1.4E-97 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS08655 0c613e46686eb88569dc7a38fe072942 422 SUPERFAMILY SSF55729 250 386 5.58E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS08655 0c613e46686eb88569dc7a38fe072942 422 SUPERFAMILY SSF55021 66 125 5.99E-5 T 17-03-2017 SHXM_RS08655 0c613e46686eb88569dc7a38fe072942 422 Pfam PF00583 Acetyltransferase (GNAT) family 319 381 8.5E-6 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS08655 0c613e46686eb88569dc7a38fe072942 422 Gene3D G3DSA:3.30.70.260 69 128 9.0E-5 T 17-03-2017 SHXM_RS08655 0c613e46686eb88569dc7a38fe072942 422 Gene3D G3DSA:3.40.630.30 253 384 1.2E-17 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 252 367 2.3E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 157 173 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Pfam PF00698 Acyl transferase domain 525 833 5.7E-63 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 370 489 5.7E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 525 815 4.8E-120 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Gene3D G3DSA:3.30.70.250 646 707 1.0E-7 T 17-03-2017 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 SUPERFAMILY SSF52151 709 811 3.14E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 SUPERFAMILY SSF52151 521 648 3.14E-71 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Gene3D G3DSA:3.40.366.10 519 642 6.3E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Gene3D G3DSA:3.40.366.10 708 817 6.3E-76 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 SMART SM00825 Beta-ketoacyl synthase 1 420 3.6E-212 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 SUPERFAMILY SSF53901 1 357 1.29E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Gene3D G3DSA:3.40.47.10 257 420 3.0E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Gene3D G3DSA:3.40.47.10 1 256 5.9E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 244 6.0E-86 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05295 a5e921168519acfebbc7e1e85184e5e2 833 SUPERFAMILY SSF55048 647 708 4.19E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 150 754 8.6E-224 T 17-03-2017 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 Pfam PF02867 Ribonucleotide reductase, barrel domain 227 750 6.1E-173 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 SUPERFAMILY SSF48168 26 225 2.09E-42 T 17-03-2017 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 Gene3D G3DSA:3.20.70.20 605 650 2.6E-76 T 17-03-2017 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 Gene3D G3DSA:3.20.70.20 399 559 2.6E-76 T 17-03-2017 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 Gene3D G3DSA:3.20.70.20 146 349 2.6E-76 T 17-03-2017 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 Gene3D G3DSA:3.20.70.20 711 750 2.6E-76 T 17-03-2017 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 SUPERFAMILY SSF51998 226 654 2.84E-173 T 17-03-2017 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 SUPERFAMILY SSF51998 685 755 2.84E-173 T 17-03-2017 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 ProSitePatterns PS00089 Ribonucleotide reductase large subunit signature. 594 616 - T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 PRINTS PR01183 Ribonucleotide reductase large chain signature 303 322 1.6E-48 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 PRINTS PR01183 Ribonucleotide reductase large chain signature 539 562 1.6E-48 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 PRINTS PR01183 Ribonucleotide reductase large chain signature 605 632 1.6E-48 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 PRINTS PR01183 Ribonucleotide reductase large chain signature 435 446 1.6E-48 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 PRINTS PR01183 Ribonucleotide reductase large chain signature 473 496 1.6E-48 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 PRINTS PR01183 Ribonucleotide reductase large chain signature 511 533 1.6E-48 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34500 a9cb261bff2818be0dbda3afdb177bae 804 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 146 223 1.9E-19 T 17-03-2017 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 Gene3D G3DSA:3.30.465.10 60 113 2.8E-31 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 Gene3D G3DSA:3.30.465.10 157 220 2.8E-31 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 Gene3D G3DSA:3.30.43.10 1 51 1.9E-17 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 228 323 2.2E-17 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 220 6.6E-46 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 SUPERFAMILY SSF55447 228 329 9.03E-24 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 SMART SM01092 227 326 2.6E-24 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 Gene3D G3DSA:3.30.390.50 227 327 1.7E-29 T 17-03-2017 SHXM_RS03555 00c63eb389a5cea6bbb7fccc94123d15 332 SUPERFAMILY SSF56176 1 220 2.23E-55 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS35855 54f4580e4acb221737d9a2a555dadeb7 406 Gene3D G3DSA:2.40.440.10 253 380 1.5E-18 T 17-03-2017 SHXM_RS35855 54f4580e4acb221737d9a2a555dadeb7 406 SUPERFAMILY SSF141523 253 380 9.55E-22 T 17-03-2017 SHXM_RS35855 54f4580e4acb221737d9a2a555dadeb7 406 Pfam PF03734 L,D-transpeptidase catalytic domain 251 354 2.6E-12 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 Pfam PF13378 Enolase C-terminal domain-like 176 387 3.5E-52 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 SMART SM00922 173 267 5.1E-24 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 37 139 1.2E-7 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 SUPERFAMILY SSF54826 7 139 2.3E-25 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 Gene3D G3DSA:3.30.390.10 8 122 9.3E-17 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 Gene3D G3DSA:3.20.20.120 123 380 3.3E-93 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS05465 f1c7ac5b7dd40231e238cfff6de39c3f 424 SUPERFAMILY SSF51604 139 396 1.77E-75 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS46945 2672409a6705a3434dbf2d8501155d2e 261 SUPERFAMILY SSF53474 6 240 3.19E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46945 2672409a6705a3434dbf2d8501155d2e 261 Pfam PF08386 TAP-like protein 178 234 5.3E-5 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS46945 2672409a6705a3434dbf2d8501155d2e 261 Gene3D G3DSA:3.40.50.1820 174 240 2.2E-21 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46945 2672409a6705a3434dbf2d8501155d2e 261 Gene3D G3DSA:3.40.50.1820 6 121 2.2E-21 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27735 7e8836ed3ebb31fac3835e4cbbb93c20 308 Gene3D G3DSA:3.40.50.300 3 218 1.5E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27735 7e8836ed3ebb31fac3835e4cbbb93c20 308 SUPERFAMILY SSF52540 4 218 1.7E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27735 7e8836ed3ebb31fac3835e4cbbb93c20 308 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS27735 7e8836ed3ebb31fac3835e4cbbb93c20 308 Pfam PF00005 ABC transporter 20 159 8.7E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS27735 7e8836ed3ebb31fac3835e4cbbb93c20 308 SMART SM00382 27 215 3.3E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS40820 c4ea16fd70946a2ceed99e59346d258e 40 Gene3D G3DSA:3.40.50.1820 1 38 4.8E-5 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40820 c4ea16fd70946a2ceed99e59346d258e 40 SUPERFAMILY SSF53474 1 38 3.93E-5 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 19 417 9.0E-102 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 ProSitePatterns PS00885 EPSP synthase signature 2. 336 354 - T 17-03-2017 IPR023193 3-phosphoshikimate 1-carboxyvinyltransferase, conserved site KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 Hamap MF_00210 3-phosphoshikimate 1-carboxyvinyltransferase [aroA]. 11 423 29.08 T 17-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 Gene3D G3DSA:3.65.10.10 234 419 3.0E-61 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 Gene3D G3DSA:3.65.10.10 23 233 1.2E-58 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 SUPERFAMILY SSF55205 19 420 8.18E-110 T 17-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 TIGRFAM TIGR01356 aroA: 3-phosphoshikimate 1-carboxyvinyltransferase 19 420 4.5E-119 T 17-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS49420 f935af775514b8058d9efe096ac3378d 426 PIRSF PIRSF000505 9 424 2.4E-124 T 17-03-2017 IPR006264 3-phosphoshikimate 1-carboxyvinyltransferase GO:0003866 KEGG: 00400+2.5.1.19|MetaCyc: PWY-6163 SHXM_RS42760 9875a34e20688cdf4227d9fff574879a 468 Pfam PF00860 Permease family 23 397 2.3E-109 T 17-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS42760 9875a34e20688cdf4227d9fff574879a 468 TIGRFAM TIGR00801 ncs2: uracil-xanthine permease 22 431 4.6E-122 T 17-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 SHXM_RS42760 9875a34e20688cdf4227d9fff574879a 468 TIGRFAM TIGR03173 pbuX: xanthine permease 26 433 3.1E-171 T 17-03-2017 IPR017588 Uric acid permease UacT-like GO:0006810|GO:0016021 SHXM_RS42760 9875a34e20688cdf4227d9fff574879a 468 ProSitePatterns PS01116 Xanthine/uracil permeases family signature. 348 368 - T 17-03-2017 IPR006042 Xanthine/uracil permease GO:0005215|GO:0016020|GO:0055085 Reactome: R-HSA-196836 SHXM_RS41475 1fcdee56c37b54fafac9bad3658c377c 140 Gene3D G3DSA:1.10.10.60 93 139 5.8E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41475 1fcdee56c37b54fafac9bad3658c377c 140 SUPERFAMILY SSF46689 40 87 1.79E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41475 1fcdee56c37b54fafac9bad3658c377c 140 Pfam PF12833 Helix-turn-helix domain 62 138 5.2E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS41475 1fcdee56c37b54fafac9bad3658c377c 140 SUPERFAMILY SSF46689 92 139 5.38E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41475 1fcdee56c37b54fafac9bad3658c377c 140 SMART SM00342 54 137 2.5E-23 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS41475 1fcdee56c37b54fafac9bad3658c377c 140 Gene3D G3DSA:1.10.10.60 33 87 6.0E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS23005 cc234d2d441cad9f8083f5ef63a61f9d 253 SUPERFAMILY SSF55781 92 242 1.44E-21 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS23005 cc234d2d441cad9f8083f5ef63a61f9d 253 Gene3D G3DSA:1.10.10.10 10 80 3.3E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23005 cc234d2d441cad9f8083f5ef63a61f9d 253 Pfam PF01614 Bacterial transcriptional regulator 134 230 2.2E-12 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS23005 cc234d2d441cad9f8083f5ef63a61f9d 253 SUPERFAMILY SSF46785 12 79 1.42E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23005 cc234d2d441cad9f8083f5ef63a61f9d 253 Pfam PF09339 IclR helix-turn-helix domain 13 62 5.9E-5 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS23005 cc234d2d441cad9f8083f5ef63a61f9d 253 Gene3D G3DSA:3.30.450.40 89 244 5.2E-25 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS50320 38388259e54b8973566c03c189e0dc8f 215 Gene3D G3DSA:3.40.50.1000 2 21 6.8E-28 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS50320 38388259e54b8973566c03c189e0dc8f 215 Gene3D G3DSA:3.40.50.1000 85 211 6.8E-28 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS50320 38388259e54b8973566c03c189e0dc8f 215 SUPERFAMILY SSF56784 2 210 3.25E-36 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS50320 38388259e54b8973566c03c189e0dc8f 215 Pfam PF13419 Haloacid dehalogenase-like hydrolase 7 179 6.0E-14 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS02620 2dce1521789bc0db2c6e67d248b0836d 274 Pfam PF13560 Helix-turn-helix domain 21 75 5.2E-14 T 17-03-2017 SHXM_RS02620 2dce1521789bc0db2c6e67d248b0836d 274 Gene3D G3DSA:1.10.260.40 21 70 1.2E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02620 2dce1521789bc0db2c6e67d248b0836d 274 SUPERFAMILY SSF47413 21 70 5.0E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 Gene3D G3DSA:3.50.50.60 281 365 2.3E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 Gene3D G3DSA:3.50.50.60 19 196 2.3E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 293 308 4.2E-34 T 17-03-2017 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 20 42 4.2E-34 T 17-03-2017 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 170 185 4.2E-34 T 17-03-2017 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 344 360 4.2E-34 T 17-03-2017 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 326 344 4.2E-34 T 17-03-2017 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 308 324 4.2E-34 T 17-03-2017 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 Pfam PF01494 FAD binding domain 19 353 3.5E-61 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 SUPERFAMILY SSF51905 19 191 3.04E-67 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39670 0371b7138396d38ca3d0a69f966fa07c 541 SUPERFAMILY SSF51905 280 382 3.04E-67 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 Hamap MF_00137 Phosphoribosylaminoimidazole-succinocarboxamide synthase [purC]. 16 302 25.377 T 17-03-2017 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 TIGRFAM TIGR00081 purC: phosphoribosylaminoimidazolesuccinocarboxamide synthase 18 305 1.1E-65 T 17-03-2017 IPR001636 Phosphoribosylaminoimidazole-succinocarboxamide synthase GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 ProSitePatterns PS01058 SAICAR synthetase signature 2. 204 212 - T 17-03-2017 IPR018236 SAICAR synthetase, conserved site GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 Gene3D G3DSA:3.30.470.20 116 254 7.1E-54 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 SUPERFAMILY SSF56104 12 305 9.81E-98 T 17-03-2017 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 Pfam PF01259 SAICAR synthetase 18 275 5.3E-99 T 17-03-2017 IPR028923 SAICAR synthetase/ADE2, N-terminal KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 ProSitePatterns PS01057 SAICAR synthetase signature 1. 105 119 - T 17-03-2017 IPR018236 SAICAR synthetase, conserved site GO:0004639|GO:0006164 KEGG: 00230+6.3.2.6|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS29355 e1ab61f88e5335db812b2c92310e3330 306 Gene3D G3DSA:3.30.200.20 11 115 2.8E-43 T 17-03-2017 SHXM_RS19140 858a9f8f280999c1eb18fcadb6607696 241 Gene3D G3DSA:1.10.357.10 4 236 8.5E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS19140 858a9f8f280999c1eb18fcadb6607696 241 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 63 3.0E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS19140 858a9f8f280999c1eb18fcadb6607696 241 SUPERFAMILY SSF48498 86 148 3.26E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19140 858a9f8f280999c1eb18fcadb6607696 241 SUPERFAMILY SSF48498 189 240 3.26E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19140 858a9f8f280999c1eb18fcadb6607696 241 SUPERFAMILY SSF46689 5 80 2.89E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 SMART SM00895 93 215 1.2E-16 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 Pfam PF07729 FCD domain 93 213 5.5E-26 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 Pfam PF00392 Bacterial regulatory proteins, gntR family 3 64 2.0E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 SMART SM00345 5 64 1.7E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 SUPERFAMILY SSF46785 4 80 9.48E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 Gene3D G3DSA:1.20.120.530 89 225 3.5E-27 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 38 54 6.4E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 24 38 6.4E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 Gene3D G3DSA:1.10.10.10 4 67 3.5E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23240 3188eabe34e0c39166b52baf4abe4131 226 SUPERFAMILY SSF48008 89 222 2.3E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS40675 55c8ff2f8e623e3149e62e72bf3b30bc 149 Gene3D G3DSA:3.30.1330.40 12 144 9.6E-41 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS40675 55c8ff2f8e623e3149e62e72bf3b30bc 149 SUPERFAMILY SSF55298 13 143 5.18E-36 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS40675 55c8ff2f8e623e3149e62e72bf3b30bc 149 Pfam PF01042 Endoribonuclease L-PSP 19 141 7.4E-27 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 TIGRFAM TIGR01033 TIGR01033: DNA-binding regulatory protein, YebC/PmpR family 1 238 1.1E-97 T 17-03-2017 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 Gene3D G3DSA:1.10.10.200 1 78 4.1E-32 T 17-03-2017 IPR017856 Integrase, N-terminal zinc-binding domain-like SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 Gene3D G3DSA:3.30.70.980 138 205 3.2E-23 T 17-03-2017 IPR026564 Transcriptional regulator TACO1-like, domain 3 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 Gene3D G3DSA:3.30.1270.10 83 137 3.4E-40 T 17-03-2017 IPR026563 Transcriptional regulator TACO1-like, domain 2 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 Gene3D G3DSA:3.30.1270.10 213 248 3.4E-40 T 17-03-2017 IPR026563 Transcriptional regulator TACO1-like, domain 2 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 Pfam PF01709 Transcriptional regulator 5 238 3.7E-88 T 17-03-2017 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 Hamap MF_00693 Probable transcriptional regulatory protein YebC [yebC]. 3 240 34.421 T 17-03-2017 IPR002876 Transcriptional regulator TACO1-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS12555 3bb272f4a3d058c877990ad18b04445a 250 SUPERFAMILY SSF75625 3 247 2.09E-89 T 17-03-2017 IPR029072 YebC-like Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 Pfam PF00196 Bacterial regulatory proteins, luxR family 234 288 2.7E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 SUPERFAMILY SSF46894 223 295 5.78E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 SMART SM00448 78 193 1.3E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 Gene3D G3DSA:3.40.50.2300 76 233 5.7E-41 T 17-03-2017 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 Pfam PF00072 Response regulator receiver domain 80 194 2.1E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 235 249 2.2E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 265 277 2.2E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 249 265 2.2E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 Gene3D G3DSA:1.10.10.10 234 294 3.4E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 SMART SM00421 232 289 1.5E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS21190 4ca9becd8506602640bbcc1bd140d4e0 300 SUPERFAMILY SSF52172 76 203 7.26E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS16290 83f90a01ac0f516d22e047dadf7be68d 238 Gene3D G3DSA:1.20.950.20 20 223 2.7E-46 T 17-03-2017 SHXM_RS16290 83f90a01ac0f516d22e047dadf7be68d 238 SUPERFAMILY SSF81342 19 219 3.45E-28 T 17-03-2017 IPR016174 Di-haem cytochrome, transmembrane GO:0016020|GO:0022904 Reactome: R-HSA-611105 SHXM_RS16290 83f90a01ac0f516d22e047dadf7be68d 238 Pfam PF01292 Prokaryotic cytochrome b561 24 189 4.7E-13 T 17-03-2017 IPR011577 Cytochrome b561, bacterial/Ni-hydrogenase GO:0009055|GO:0016021 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 PIRSF PIRSF002191 1 116 1.4E-49 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 Pfam PF01245 Ribosomal protein L19 4 113 8.6E-50 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 PRINTS PR00061 Ribosomal protein L19 signature 4 33 1.1E-42 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 PRINTS PR00061 Ribosomal protein L19 signature 34 63 1.1E-42 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 PRINTS PR00061 Ribosomal protein L19 signature 88 113 1.1E-42 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 TIGRFAM TIGR01024 rplS_bact: ribosomal protein bL19 3 113 1.1E-48 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 SUPERFAMILY SSF50104 3 115 6.12E-46 T 17-03-2017 IPR008991 Translation protein SH3-like domain SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 Hamap MF_00402 50S ribosomal protein L19 [rplS]. 2 114 29.334 T 17-03-2017 IPR001857 Ribosomal protein L19 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36590 9b87b35270a14b2ee929fa664cb6fb8e 116 ProSitePatterns PS01015 Ribosomal protein L19 signature. 86 101 - T 17-03-2017 IPR018257 Ribosomal protein L19, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS32400 0f20ebfce675be18e04e5bec9e214edb 180 Pfam PF16976 Flp pilus assembly protein RcpC/CpaB 51 177 5.9E-8 T 17-03-2017 IPR031571 Flp pilus assembly protein RcpC/CpaB domain SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 ProSitePatterns PS01224 N-acetyl-gamma-glutamyl-phosphate reductase active site. 141 157 - T 17-03-2017 IPR023013 N-acetyl-gamma-glutamyl-phosphate reductase, active site GO:0003942|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 155 313 3.5E-17 T 17-03-2017 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 4 128 1.6E-25 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 SUPERFAMILY SSF55347 146 310 2.22E-46 T 17-03-2017 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 Hamap MF_00150 N-acetyl-gamma-glutamyl-phosphate reductase [argC]. 3 336 37.521 T 17-03-2017 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 Gene3D G3DSA:3.30.360.10 155 310 3.6E-56 T 17-03-2017 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 SMART SM00859 4 136 6.2E-42 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 Gene3D G3DSA:3.40.50.720 2 154 8.5E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 TIGRFAM TIGR01850 argC: N-acetyl-gamma-glutamyl-phosphate reductase 3 342 3.1E-115 T 17-03-2017 IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1 GO:0003942|GO:0006526|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12995 be1d5dbe24f83e36f7bfeb13b9e835cb 342 SUPERFAMILY SSF51735 3 170 2.24E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33725 1ec1f4fd33dbd57f8cf9d413758a8e03 415 Gene3D G3DSA:1.20.1250.20 27 204 1.7E-26 T 17-03-2017 SHXM_RS33725 1ec1f4fd33dbd57f8cf9d413758a8e03 415 ProSitePatterns PS00217 Sugar transport proteins signature 2. 122 147 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS33725 1ec1f4fd33dbd57f8cf9d413758a8e03 415 SUPERFAMILY SSF103473 22 407 8.11E-62 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS33725 1ec1f4fd33dbd57f8cf9d413758a8e03 415 Gene3D G3DSA:1.20.1250.20 233 404 3.9E-19 T 17-03-2017 SHXM_RS33725 1ec1f4fd33dbd57f8cf9d413758a8e03 415 Pfam PF07690 Major Facilitator Superfamily 53 296 1.3E-30 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS07405 d7b84abcf4d258561655d4fde6df812b 294 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 6 155 3.3E-21 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS07405 d7b84abcf4d258561655d4fde6df812b 294 PIRSF PIRSF000103 1 294 9.4E-36 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS07405 d7b84abcf4d258561655d4fde6df812b 294 SUPERFAMILY SSF51735 6 155 1.97E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07405 d7b84abcf4d258561655d4fde6df812b 294 Gene3D G3DSA:3.40.50.720 2 160 7.0E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17810 8597a4ac303a0ead4837bbfa8fb41577 418 TIGRFAM TIGR01979 sufS: cysteine desulfurase, SufS family 12 418 4.8E-186 T 17-03-2017 IPR010970 Cysteine desulfurase, SufS GO:0006534|GO:0030170|GO:0031071 KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SHXM_RS17810 8597a4ac303a0ead4837bbfa8fb41577 418 Gene3D G3DSA:3.40.640.10 42 293 1.3E-85 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS17810 8597a4ac303a0ead4837bbfa8fb41577 418 SUPERFAMILY SSF53383 9 413 3.64E-124 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS17810 8597a4ac303a0ead4837bbfa8fb41577 418 Gene3D G3DSA:3.90.1150.10 294 412 1.8E-28 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS17810 8597a4ac303a0ead4837bbfa8fb41577 418 Pfam PF00266 Aminotransferase class-V 31 406 8.1E-152 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 Gene3D G3DSA:1.10.240.10 224 323 6.2E-11 T 17-03-2017 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 Gene3D G3DSA:3.40.50.620 7 223 1.8E-80 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 17 26 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 SUPERFAMILY SSF52374 10 335 9.0E-78 T 17-03-2017 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 Hamap MF_00140_B Tryptophan--tRNA ligase [trpS]. 8 336 36.115 T 17-03-2017 IPR024109 Tryptophan-tRNA ligase, bacterial-type GO:0004830 KEGG: 00970+6.1.1.2|Reactome: R-HSA-379726 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 TIGRFAM TIGR00233 trpS: tryptophan--tRNA ligase 9 335 1.9E-93 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 21 37 7.0E-22 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 151 172 7.0E-22 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 72 91 7.0E-22 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 204 214 7.0E-22 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS30375 9c636c3b99a62f5ef4320872017d36a4 339 Pfam PF00579 tRNA synthetases class I (W and Y) 6 290 1.9E-66 T 17-03-2017 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS23950 3c5a8df7356683ff4a37777865731d03 174 SMART SM00347 48 151 2.6E-18 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS23950 3c5a8df7356683ff4a37777865731d03 174 Pfam PF12802 MarR family 53 115 3.3E-12 T 17-03-2017 SHXM_RS23950 3c5a8df7356683ff4a37777865731d03 174 SUPERFAMILY SSF46785 17 165 2.73E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23950 3c5a8df7356683ff4a37777865731d03 174 Gene3D G3DSA:1.10.10.10 15 167 3.5E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23950 3c5a8df7356683ff4a37777865731d03 174 ProSitePatterns PS01117 MarR-type HTH domain signature. 90 124 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS22300 e27b84055e1fa1e79cb7eef87e92aa18 219 SUPERFAMILY SSF46689 15 87 1.5E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22300 e27b84055e1fa1e79cb7eef87e92aa18 219 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 74 6.3E-16 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22300 e27b84055e1fa1e79cb7eef87e92aa18 219 Gene3D G3DSA:1.10.357.10 14 210 9.8E-33 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS22300 e27b84055e1fa1e79cb7eef87e92aa18 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 42 2.4E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22300 e27b84055e1fa1e79cb7eef87e92aa18 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 50 73 2.4E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22300 e27b84055e1fa1e79cb7eef87e92aa18 219 ProSitePatterns PS01081 TetR-type HTH domain signature. 41 71 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS18450 3248f689ad23452dc0080710dffd16e1 346 ProSitePatterns PS00211 ABC transporters family signature. 158 172 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS18450 3248f689ad23452dc0080710dffd16e1 346 SUPERFAMILY SSF52540 10 248 1.25E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18450 3248f689ad23452dc0080710dffd16e1 346 Gene3D G3DSA:3.40.50.300 7 247 4.9E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18450 3248f689ad23452dc0080710dffd16e1 346 Pfam PF00005 ABC transporter 43 186 2.2E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS18450 3248f689ad23452dc0080710dffd16e1 346 SMART SM00382 51 235 1.2E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 Pfam PF07728 AAA domain (dynein-related subfamily) 129 285 4.9E-5 T 17-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 SUPERFAMILY SSF52540 117 253 4.71E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 SUPERFAMILY SSF52540 280 346 4.71E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 SMART SM00382 125 317 8.1E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 Gene3D G3DSA:3.40.50.300 89 138 7.2E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 Gene3D G3DSA:3.40.50.300 139 172 6.3E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 Gene3D G3DSA:3.40.50.300 220 253 6.3E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07685 ae42f8734ad6b4f41253fe670a63a3cc 393 Gene3D G3DSA:3.40.50.300 287 345 6.3E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 SUPERFAMILY SSF52922 633 776 1.57E-24 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 Gene3D G3DSA:3.40.50.970 408 625 2.4E-67 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 PIRSF PIRSF000156 10 777 2.1E-63 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 SUPERFAMILY SSF52518 404 617 7.85E-47 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 SUPERFAMILY SSF52518 16 387 2.04E-62 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 Gene3D G3DSA:3.40.50.920 638 776 3.4E-34 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 SMART SM00861 413 617 5.1E-9 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 59 231 1.1E-8 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS44330 8f3cc339dcc45b741ea688d316015ce6 777 Gene3D G3DSA:3.40.50.970 14 387 2.4E-92 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS11005 8f2f77a4dbe007b5f3df60bec4999ea9 531 Pfam PF00474 Sodium:solute symporter family 44 453 6.2E-86 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS13730 cb071db5a71762c6f2117bb910b21b7e 301 Gene3D G3DSA:1.10.10.10 13 88 1.6E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13730 cb071db5a71762c6f2117bb910b21b7e 301 Gene3D G3DSA:3.40.50.10490 112 271 6.7E-23 T 17-03-2017 SHXM_RS13730 cb071db5a71762c6f2117bb910b21b7e 301 Pfam PF01380 SIS domain 140 266 1.6E-12 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS13730 cb071db5a71762c6f2117bb910b21b7e 301 SUPERFAMILY SSF46689 14 86 1.25E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13730 cb071db5a71762c6f2117bb910b21b7e 301 SUPERFAMILY SSF53697 109 269 5.06E-23 T 17-03-2017 SHXM_RS13730 cb071db5a71762c6f2117bb910b21b7e 301 Pfam PF01418 Helix-turn-helix domain, rpiR family 13 83 1.8E-8 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 Pfam PF09339 IclR helix-turn-helix domain 30 75 1.1E-12 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 Gene3D G3DSA:3.30.450.40 88 261 9.5E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 SUPERFAMILY SSF55781 85 261 2.68E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 Gene3D G3DSA:1.10.10.10 13 81 4.7E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 Pfam PF01614 Bacterial transcriptional regulator 137 252 5.0E-19 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 SMART SM00346 22 110 2.1E-10 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS45760 17ae7291909b233bb8a470f2fb58616b 270 SUPERFAMILY SSF46785 25 93 4.67E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 162 187 1.5E-11 T 17-03-2017 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 12 34 1.5E-11 T 17-03-2017 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 289 296 1.5E-11 T 17-03-2017 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 Gene3D G3DSA:3.50.50.60 175 314 8.1E-12 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 SUPERFAMILY SSF51905 3 319 3.7E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 Gene3D G3DSA:3.40.50.720 9 174 1.1E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 12 302 1.5E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 13 32 1.5E-11 T 17-03-2017 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 115 133 1.5E-11 T 17-03-2017 SHXM_RS44955 236cfc9b1be478d1099f98dfaca24179 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 274 296 1.5E-11 T 17-03-2017 SHXM_RS02220 3ec6dd8c6af390b3d654fce7bdb39b23 467 Gene3D G3DSA:3.40.309.10 252 435 5.5E-63 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS02220 3ec6dd8c6af390b3d654fce7bdb39b23 467 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 237 244 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS02220 3ec6dd8c6af390b3d654fce7bdb39b23 467 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 265 276 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS02220 3ec6dd8c6af390b3d654fce7bdb39b23 467 SUPERFAMILY SSF53720 11 456 4.19E-140 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS02220 3ec6dd8c6af390b3d654fce7bdb39b23 467 Pfam PF00171 Aldehyde dehydrogenase family 15 452 1.9E-136 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS02220 3ec6dd8c6af390b3d654fce7bdb39b23 467 Gene3D G3DSA:3.40.605.10 14 251 1.4E-73 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS02100 7700fe039d98bcd9e4727b80cbd83cdc 190 SUPERFAMILY SSF55961 18 94 1.07E-6 T 17-03-2017 SHXM_RS02100 7700fe039d98bcd9e4727b80cbd83cdc 190 SUPERFAMILY SSF55961 127 185 1.07E-6 T 17-03-2017 SHXM_RS02100 7700fe039d98bcd9e4727b80cbd83cdc 190 Gene3D G3DSA:3.30.530.20 18 86 1.7E-6 T 17-03-2017 IPR023393 START-like domain SHXM_RS02100 7700fe039d98bcd9e4727b80cbd83cdc 190 Gene3D G3DSA:3.30.530.20 123 187 1.7E-6 T 17-03-2017 IPR023393 START-like domain SHXM_RS42190 bb6d55fccb0d5625eb62610c56d80b8d 193 PIRSF PIRSF019325 3 193 1.2E-68 T 17-03-2017 IPR016758 Glucose-6-phosphate isomerase, archaea/bacteria GO:0004347|GO:0005506 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385 SHXM_RS42190 bb6d55fccb0d5625eb62610c56d80b8d 193 Gene3D G3DSA:2.60.120.10 22 192 7.2E-39 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS42190 bb6d55fccb0d5625eb62610c56d80b8d 193 Pfam PF06560 Glucose-6-phosphate isomerase (GPI) 28 179 7.1E-28 T 17-03-2017 IPR010551 Glucose-6-phosphate isomerase, prokaryote GO:0004347|GO:0005737|GO:0006094|GO:0006096 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385 SHXM_RS42190 bb6d55fccb0d5625eb62610c56d80b8d 193 SUPERFAMILY SSF51182 6 191 2.42E-33 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 Gene3D G3DSA:3.40.190.10 175 261 2.8E-22 T 17-03-2017 SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 SUPERFAMILY SSF46785 2 85 1.53E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 1 59 5.5E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 Gene3D G3DSA:1.10.10.10 1 82 6.3E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 Pfam PF03466 LysR substrate binding domain 85 289 9.8E-28 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 SUPERFAMILY SSF53850 88 293 4.44E-26 T 17-03-2017 SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 27 37 2.1E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 37 48 2.1E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 16 27 2.1E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33000 efe823578819bea40b652e8a1d32a67c 325 Gene3D G3DSA:3.40.190.10 86 174 7.9E-16 T 17-03-2017 SHXM_RS25270 0aa64ca0e163a47575c551f60b5f8542 218 Pfam PF00551 Formyl transferase 18 200 5.6E-56 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS25270 0aa64ca0e163a47575c551f60b5f8542 218 Hamap MF_01930 Phosphoribosylglycinamide formyltransferase [purN]. 18 206 30.106 T 17-03-2017 IPR004607 Phosphoribosylglycinamide formyltransferase GO:0004644|GO:0006189 KEGG: 00230+2.1.2.2|KEGG: 00670+2.1.2.2|MetaCyc: PWY-6121|MetaCyc: PWY-6613|Reactome: R-HSA-73817 SHXM_RS25270 0aa64ca0e163a47575c551f60b5f8542 218 TIGRFAM TIGR00639 PurN: phosphoribosylglycinamide formyltransferase 18 210 2.0E-70 T 17-03-2017 IPR004607 Phosphoribosylglycinamide formyltransferase GO:0004644|GO:0006189 KEGG: 00230+2.1.2.2|KEGG: 00670+2.1.2.2|MetaCyc: PWY-6121|MetaCyc: PWY-6613|Reactome: R-HSA-73817 SHXM_RS25270 0aa64ca0e163a47575c551f60b5f8542 218 SUPERFAMILY SSF53328 18 214 1.83E-61 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS25270 0aa64ca0e163a47575c551f60b5f8542 218 Gene3D G3DSA:3.40.50.170 17 213 1.3E-72 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS25270 0aa64ca0e163a47575c551f60b5f8542 218 ProSitePatterns PS00373 Phosphoribosylglycinamide formyltransferase active site. 152 175 - T 17-03-2017 IPR001555 Phosphoribosylglycinamide formyltransferase, active site KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS01050 7c20eef83d6aa3058d6ae99071e293ba 354 Pfam PF13407 Periplasmic binding protein domain 37 270 1.2E-28 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS01050 7c20eef83d6aa3058d6ae99071e293ba 354 Gene3D G3DSA:3.40.50.2300 35 160 7.4E-18 T 17-03-2017 SHXM_RS01050 7c20eef83d6aa3058d6ae99071e293ba 354 Gene3D G3DSA:3.40.50.2300 161 317 1.2E-28 T 17-03-2017 SHXM_RS01050 7c20eef83d6aa3058d6ae99071e293ba 354 SUPERFAMILY SSF53822 34 317 6.06E-50 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 SUPERFAMILY SSF48008 95 231 1.78E-30 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 Pfam PF07729 FCD domain 98 223 1.3E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 SMART SM00895 98 224 2.3E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 34 48 6.3E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 48 64 6.3E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 Pfam PF00392 Bacterial regulatory proteins, gntR family 11 74 1.5E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 Gene3D G3DSA:1.10.10.10 8 78 7.3E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 SMART SM00345 15 74 1.2E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 SUPERFAMILY SSF46785 5 78 2.81E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02865 e6ba056bcbdf83655b31cc763d758e46 251 Gene3D G3DSA:1.20.120.530 92 232 2.9E-34 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.30.365.10 168 271 3.5E-35 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 154 639 3.2E-106 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 SMART SM01008 22 128 2.7E-30 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.30.365.10 432 530 6.3E-21 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.90.1170.50 6 115 5.1E-32 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.30.365.10 275 328 1.4E-8 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.30.365.10 116 167 1.4E-8 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.30.365.10 555 701 2.5E-56 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Gene3D G3DSA:3.30.365.10 348 431 2.5E-56 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 SUPERFAMILY SSF56003 126 701 5.5E-151 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 22 128 6.1E-19 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS06270 eb4a487a555705a3cad61d272af0518a 720 SUPERFAMILY SSF54665 6 131 6.15E-33 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS27570 1c1734171b72dc0f3770a8f76656080e 331 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 215 251 4.3E-7 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS27570 1c1734171b72dc0f3770a8f76656080e 331 Gene3D G3DSA:3.10.129.10 36 167 6.4E-8 T 17-03-2017 IPR029069 HotDog domain SHXM_RS27570 1c1734171b72dc0f3770a8f76656080e 331 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 253 314 4.8E-23 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS27570 1c1734171b72dc0f3770a8f76656080e 331 SUPERFAMILY SSF54637 40 170 1.95E-11 T 17-03-2017 IPR029069 HotDog domain SHXM_RS27570 1c1734171b72dc0f3770a8f76656080e 331 Pfam PF13452 N-terminal half of MaoC dehydratase 36 160 2.1E-10 T 17-03-2017 SHXM_RS27570 1c1734171b72dc0f3770a8f76656080e 331 SUPERFAMILY SSF50249 200 321 1.01E-34 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 Pfam PF00455 DeoR C terminal sensor domain 76 232 1.8E-40 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 SMART SM01134 73 234 1.3E-60 T 17-03-2017 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 Gene3D G3DSA:3.40.50.1360 77 216 2.0E-9 T 17-03-2017 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 SUPERFAMILY SSF46785 5 68 2.63E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 Gene3D G3DSA:1.10.10.10 1 57 5.3E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 1.9E-16 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 1.9E-6 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 1.9E-6 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 SUPERFAMILY SSF100950 76 234 3.68E-26 T 17-03-2017 SHXM_RS40465 2c746b118eb75f3b1158125cffe9eded 253 SMART SM00420 6 58 4.5E-19 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS12450 0ccfc2f61d571414fd9d134299aac909 148 Pfam PF06103 Bacterial protein of unknown function (DUF948) 6 86 2.7E-13 T 17-03-2017 IPR009293 Uncharacterised protein family UPF0478 SHXM_RS10580 d5b5b9157c59e0e94d1367a831d07db6 304 SUPERFAMILY SSF47413 29 82 5.04E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10580 d5b5b9157c59e0e94d1367a831d07db6 304 Gene3D G3DSA:1.10.260.40 5 82 4.3E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10580 d5b5b9157c59e0e94d1367a831d07db6 304 Pfam PF13560 Helix-turn-helix domain 8 86 2.7E-14 T 17-03-2017 SHXM_RS10580 d5b5b9157c59e0e94d1367a831d07db6 304 SMART SM00530 11 83 4.7E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SUPERFAMILY SSF55945 212 311 5.65E-21 T 17-03-2017 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SMART SM00478 342 493 2.6E-7 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Pfam PF12833 Helix-turn-helix domain 104 182 2.6E-16 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Pfam PF02805 Metal binding domain of Ada 6 69 1.2E-29 T 17-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SUPERFAMILY SSF48150 322 489 3.31E-36 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SUPERFAMILY SSF46689 135 182 2.15E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Gene3D G3DSA:3.30.310.20 212 332 1.1E-32 T 17-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SMART SM00342 98 181 1.6E-15 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Gene3D G3DSA:1.10.1670.10 450 491 5.1E-10 T 17-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SMART SM01009 211 332 2.9E-43 T 17-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Gene3D G3DSA:1.10.10.60 136 183 5.4E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Gene3D G3DSA:1.10.340.30 333 448 3.6E-32 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Gene3D G3DSA:1.10.10.60 81 135 5.2E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Gene3D G3DSA:3.40.10.10 2 80 3.9E-34 T 17-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 SUPERFAMILY SSF57884 2 80 2.75E-31 T 17-03-2017 IPR004026 Ada DNA repair, metal-binding GO:0003677|GO:0006281|GO:0006355|GO:0008168|GO:0008270 SHXM_RS03170 162e70a4c9d6ac36847c756ca8da19d6 497 Pfam PF06029 AlkA N-terminal domain 212 332 2.1E-32 T 17-03-2017 IPR010316 DNA-3-methyladenine glycosylase AlkA, N-terminal SHXM_RS01400 a5c16db0905700814014dd1905e2c9d2 947 Gene3D G3DSA:1.50.10.10 315 437 5.7E-6 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS01400 a5c16db0905700814014dd1905e2c9d2 947 Pfam PF05592 Bacterial alpha-L-rhamnosidase 244 619 2.2E-20 T 17-03-2017 IPR008902 Bacterial alpha-L-rhamnosidase SHXM_RS01400 a5c16db0905700814014dd1905e2c9d2 947 SUPERFAMILY SSF48208 195 626 2.15E-48 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS29830 4a3e62ce28e36f6f4e407f0bfd5b968c 651 SMART SM00331 304 514 1.9E-37 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29830 4a3e62ce28e36f6f4e407f0bfd5b968c 651 Pfam PF13581 Histidine kinase-like ATPase domain 538 629 8.2E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29830 4a3e62ce28e36f6f4e407f0bfd5b968c 651 SUPERFAMILY SSF55874 557 646 1.32E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29830 4a3e62ce28e36f6f4e407f0bfd5b968c 651 SUPERFAMILY SSF81606 317 513 1.86E-9 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29830 4a3e62ce28e36f6f4e407f0bfd5b968c 651 Gene3D G3DSA:3.30.450.20 79 155 6.0E-5 T 17-03-2017 SHXM_RS29830 4a3e62ce28e36f6f4e407f0bfd5b968c 651 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 331 514 2.2E-48 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS46200 fdaad351836b2768549f228ed217f84b 224 Pfam PF14099 Polysaccharide lyase 74 214 2.8E-11 T 17-03-2017 IPR025975 Polysaccharide lyase MetaCyc: PWY-7644 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 Pfam PF02803 Thiolase, C-terminal domain 253 359 2.2E-7 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 Gene3D G3DSA:3.40.47.10 246 362 1.1E-16 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 Gene3D G3DSA:3.40.47.10 149 186 1.1E-16 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 Gene3D G3DSA:3.40.47.10 28 116 1.8E-12 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 Gene3D G3DSA:3.40.47.10 201 227 1.8E-12 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 SUPERFAMILY SSF53901 235 364 4.45E-23 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 SUPERFAMILY SSF53901 9 228 5.15E-19 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31755 fe18aafd2bf0a3a9bc9f76aa1d5e2573 392 PIRSF PIRSF000429 5 379 7.4E-29 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 Gene3D G3DSA:3.40.50.270 2 148 2.6E-44 T 17-03-2017 SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 SMART SM00226 1 147 3.8E-43 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 3 20 1.8E-17 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 46 62 1.8E-17 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 78 93 1.8E-17 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 119 134 1.8E-17 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 3 145 2.9E-36 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS02780 8d5c12e8d147f27b666234c0a84c67f3 154 SUPERFAMILY SSF52788 2 148 3.92E-40 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS24245 02f64df13864bcc558eff27e0c83f97b 479 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 308 459 4.9E-11 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS24245 02f64df13864bcc558eff27e0c83f97b 479 SMART SM00701 284 432 5.6E-54 T 17-03-2017 IPR006619 Peptidoglycan recognition protein family domain, metazoa/bacteria GO:0008270|GO:0008745|GO:0009253 SHXM_RS24245 02f64df13864bcc558eff27e0c83f97b 479 Gene3D G3DSA:3.40.80.10 280 476 2.7E-51 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS24245 02f64df13864bcc558eff27e0c83f97b 479 SUPERFAMILY SSF55846 284 471 8.92E-48 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS15550 d28e931c52543345dde58a72f49d6a91 259 Pfam PF13358 DDE superfamily endonuclease 164 248 1.5E-15 T 17-03-2017 SHXM_RS15550 d28e931c52543345dde58a72f49d6a91 259 Pfam PF13592 Winged helix-turn helix 91 148 2.5E-19 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS15550 d28e931c52543345dde58a72f49d6a91 259 SUPERFAMILY SSF46689 7 124 8.42E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15550 d28e931c52543345dde58a72f49d6a91 259 Pfam PF13518 Helix-turn-helix domain 10 59 1.5E-8 T 17-03-2017 SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 Gene3D G3DSA:3.40.50.720 19 256 4.2E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 SUPERFAMILY SSF51735 16 251 9.61E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 22 207 0.0018 T 17-03-2017 SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 97 108 5.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 164 5.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 176 195 5.8E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 163 191 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 Pfam PF00106 short chain dehydrogenase 23 218 4.0E-55 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 227 247 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 97 108 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 166 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 23 40 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 195 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 197 214 2.4E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS03460 f02a1a60cca1648e5071946600c2cbfb 265 PIRSF PIRSF000126 5 263 8.9E-55 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS14515 667704fac31519585706addcc96209a3 382 Pfam PF03992 Antibiotic biosynthesis monooxygenase 19 91 1.7E-15 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS14515 667704fac31519585706addcc96209a3 382 Pfam PF04486 SchA/CurD like domain 138 247 1.9E-46 T 17-03-2017 IPR007575 SchA/CurD-like domain SHXM_RS14515 667704fac31519585706addcc96209a3 382 SUPERFAMILY SSF54909 19 106 1.11E-18 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS14515 667704fac31519585706addcc96209a3 382 Gene3D G3DSA:3.30.70.900 21 107 9.3E-16 T 17-03-2017 SHXM_RS12740 7a7ef589d27ffbff88ae384f9caf2d62 314 Gene3D G3DSA:3.90.1200.10 84 251 1.6E-10 T 17-03-2017 SHXM_RS12740 7a7ef589d27ffbff88ae384f9caf2d62 314 SUPERFAMILY SSF56112 184 258 4.25E-15 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS12740 7a7ef589d27ffbff88ae384f9caf2d62 314 SUPERFAMILY SSF56112 7 138 4.25E-15 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS11955 aa4074850d7397aea0e9eaaa4524528b 609 SMART SM00729 213 442 1.2E-14 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS11955 aa4074850d7397aea0e9eaaa4524528b 609 Pfam PF04055 Radical SAM superfamily 217 396 1.6E-11 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS11955 aa4074850d7397aea0e9eaaa4524528b 609 SUPERFAMILY SSF102114 214 426 5.1E-22 T 17-03-2017 SHXM_RS11955 aa4074850d7397aea0e9eaaa4524528b 609 Gene3D G3DSA:3.80.30.20 215 453 1.3E-28 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS11955 aa4074850d7397aea0e9eaaa4524528b 609 SUPERFAMILY SSF52242 52 161 3.37E-6 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS11955 aa4074850d7397aea0e9eaaa4524528b 609 Pfam PF02310 B12 binding domain 51 154 3.1E-16 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS44045 b9a95fe34f73b2af74b24b77c08d0f60 234 SUPERFAMILY SSF52499 17 222 4.19E-35 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS44045 b9a95fe34f73b2af74b24b77c08d0f60 234 Gene3D G3DSA:3.40.50.850 24 223 9.5E-33 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS44045 b9a95fe34f73b2af74b24b77c08d0f60 234 Pfam PF00857 Isochorismatase family 29 213 2.8E-21 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS18485 a2d7dc147aa20cc8ff3d620167e5d3b5 275 SUPERFAMILY SSF52833 81 269 1.07E-15 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18485 a2d7dc147aa20cc8ff3d620167e5d3b5 275 Gene3D G3DSA:3.40.30.10 87 270 1.1E-21 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18485 a2d7dc147aa20cc8ff3d620167e5d3b5 275 Pfam PF13462 Thioredoxin 86 270 4.2E-35 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS35460 2637f42196ee6f7bd10fd2c695e5cc1a 97 Gene3D G3DSA:3.30.70.930 1 92 2.8E-35 T 17-03-2017 IPR029756 MTH1187/YkoF-like SHXM_RS35460 2637f42196ee6f7bd10fd2c695e5cc1a 97 SUPERFAMILY SSF89957 1 95 8.37E-30 T 17-03-2017 IPR029756 MTH1187/YkoF-like SHXM_RS35460 2637f42196ee6f7bd10fd2c695e5cc1a 97 TIGRFAM TIGR00106 TIGR00106: uncharacterized protein, MTH1187 family 1 94 5.6E-19 T 17-03-2017 IPR002767 Thiamine-binding protein SHXM_RS35460 2637f42196ee6f7bd10fd2c695e5cc1a 97 Pfam PF01910 Thiamine-binding protein 3 92 8.1E-30 T 17-03-2017 IPR002767 Thiamine-binding protein SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 Gene3D G3DSA:3.40.50.300 283 434 3.7E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 Pfam PF00271 Helicase conserved C-terminal domain 310 408 1.9E-24 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 SMART SM00490 327 408 1.8E-28 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 Gene3D G3DSA:3.40.50.300 72 282 1.3E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 SUPERFAMILY SSF52540 145 426 3.48E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 Pfam PF00270 DEAD/DEAH box helicase 98 265 9.0E-44 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS39925 2eb800d03cb4794714687f57d9312811 503 SMART SM00487 93 293 1.3E-46 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS02740 780e2994857061afb214077ca1ee1d11 297 Gene3D G3DSA:3.40.50.720 7 167 2.6E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02740 780e2994857061afb214077ca1ee1d11 297 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 10 166 4.1E-18 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS02740 780e2994857061afb214077ca1ee1d11 297 Gene3D G3DSA:1.10.1040.10 185 293 1.6E-6 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS02740 780e2994857061afb214077ca1ee1d11 297 PIRSF PIRSF000103 2 297 1.2E-36 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS02740 780e2994857061afb214077ca1ee1d11 297 SUPERFAMILY SSF51735 10 166 9.24E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Pfam PF13191 AAA ATPase domain 20 190 2.5E-29 T 17-03-2017 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 1019 1031 2.9E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 1003 1019 2.9E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 989 1003 2.9E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Pfam PF00196 Bacterial regulatory proteins, luxR family 989 1043 1.5E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Gene3D G3DSA:1.10.10.10 980 1048 7.7E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Gene3D G3DSA:1.25.40.10 588 829 2.1E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Gene3D G3DSA:1.25.40.10 479 506 2.1E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Gene3D G3DSA:3.40.50.300 126 214 1.1E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 Gene3D G3DSA:3.40.50.300 20 80 1.1E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 SUPERFAMILY SSF48452 571 739 4.74E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 SMART SM00421 986 1043 6.5E-27 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 SUPERFAMILY SSF46894 983 1049 4.08E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS36130 195141134be30ed4d042824f1e51d8c3 1059 SUPERFAMILY SSF52540 19 272 1.39E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44880 06c41dcd27128444fc1c32a14008cee9 168 Pfam PF13581 Histidine kinase-like ATPase domain 37 133 2.7E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS44880 06c41dcd27128444fc1c32a14008cee9 168 SUPERFAMILY SSF55874 60 130 5.52E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 Pfam PF00106 short chain dehydrogenase 6 192 7.3E-53 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 6.2E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 6.2E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 6.2E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 SUPERFAMILY SSF51735 4 238 1.64E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09515 292fd16940f48521407eaa63e2fdd55f 255 Gene3D G3DSA:3.40.50.720 5 235 1.5E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22345 382bd78521e02c7095043e380dc71c80 131 Hamap MF_01661 D-ribose pyranase [rbsD]. 1 131 29.917 T 17-03-2017 IPR023064 D-ribose pyranase GO:0016872 SHXM_RS22345 382bd78521e02c7095043e380dc71c80 131 ProSitePatterns PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 15 24 - T 17-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SHXM_RS22345 382bd78521e02c7095043e380dc71c80 131 Gene3D G3DSA:3.40.1650.10 3 130 1.1E-25 T 17-03-2017 IPR023750 RbsD-like domain GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 SHXM_RS22345 382bd78521e02c7095043e380dc71c80 131 Pfam PF05025 RbsD / FucU transport protein family 2 129 5.9E-39 T 17-03-2017 IPR007721 D-ribose pyranase RbsD/L-fucose mutarotase FucU GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 SHXM_RS22345 382bd78521e02c7095043e380dc71c80 131 SUPERFAMILY SSF102546 2 131 1.03E-38 T 17-03-2017 IPR023750 RbsD-like domain GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 SHXM_RS48675 d8e58d5180267ceae4a32df5b2bda096 254 ProSitePatterns PS00211 ABC transporters family signature. 151 165 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48675 d8e58d5180267ceae4a32df5b2bda096 254 PIRSF PIRSF039085 2 254 9.1E-121 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS48675 d8e58d5180267ceae4a32df5b2bda096 254 Gene3D G3DSA:3.40.50.300 5 251 3.0E-82 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48675 d8e58d5180267ceae4a32df5b2bda096 254 SUPERFAMILY SSF52540 5 249 3.71E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48675 d8e58d5180267ceae4a32df5b2bda096 254 SMART SM00382 30 227 3.4E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS48675 d8e58d5180267ceae4a32df5b2bda096 254 Pfam PF00005 ABC transporter 21 179 1.5E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 ProSitePatterns PS00622 LuxR-type HTH domain signature. 159 186 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 SUPERFAMILY SSF46894 143 204 1.42E-18 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 Pfam PF00072 Response regulator receiver domain 4 117 6.5E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 SMART SM00448 1 116 1.4E-34 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 SMART SM00421 142 199 1.2E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 Gene3D G3DSA:1.10.10.10 121 205 1.5E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 175 187 9.5E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 145 159 9.5E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 175 9.5E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 Pfam PF00196 Bacterial regulatory proteins, luxR family 145 199 2.4E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 Gene3D G3DSA:3.40.50.2300 1 120 5.7E-34 T 17-03-2017 SHXM_RS03790 d377eca267c03e4a8dcdcdc835029897 206 SUPERFAMILY SSF52172 2 163 2.02E-31 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS50105 4d3813c10c4d09405106c947d5714e1a 426 Pfam PF00202 Aminotransferase class-III 4 406 1.7E-86 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS50105 4d3813c10c4d09405106c947d5714e1a 426 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 217 254 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS50105 4d3813c10c4d09405106c947d5714e1a 426 Gene3D G3DSA:3.90.1150.10 290 409 4.0E-26 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS50105 4d3813c10c4d09405106c947d5714e1a 426 Gene3D G3DSA:3.40.640.10 38 289 9.2E-66 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS50105 4d3813c10c4d09405106c947d5714e1a 426 SUPERFAMILY SSF53383 3 409 4.84E-100 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 Gene3D G3DSA:2.30.250.10 91 217 2.3E-39 T 17-03-2017 IPR023358 Peptidase M18, domain 2 GO:0004177 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 SUPERFAMILY SSF101821 92 210 4.03E-31 T 17-03-2017 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 Pfam PF02127 Aminopeptidase I zinc metalloprotease (M18) 18 426 3.3E-123 T 17-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 Gene3D G3DSA:3.40.630.10 220 428 6.0E-103 T 17-03-2017 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 Gene3D G3DSA:3.40.630.10 11 90 6.0E-103 T 17-03-2017 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 SUPERFAMILY SSF53187 211 428 1.44E-94 T 17-03-2017 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 SUPERFAMILY SSF53187 11 91 1.44E-94 T 17-03-2017 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 Hamap MF_00467 Probable M18 family aminopeptidase 2 [apeB]. 1 429 55.732 T 17-03-2017 IPR022984 M18 family aminopeptidase 2, putative GO:0004177 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 80 96 1.8E-36 T 17-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 394 409 1.8E-36 T 17-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 262 280 1.8E-36 T 17-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 305 321 1.8E-36 T 17-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 SHXM_RS28490 bd9efddee9827ea2e24ce4469e39320b 429 PRINTS PR00932 Aminopeptidase I zinc metalloprotease (M18) signature 113 133 1.8E-36 T 17-03-2017 IPR001948 Peptidase M18 GO:0004177|GO:0006508|GO:0008270 SHXM_RS07470 65bc11707463447290c3c52e86bb09c4 235 SUPERFAMILY SSF48613 8 221 1.36E-56 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS07470 65bc11707463447290c3c52e86bb09c4 235 Pfam PF03070 TENA/THI-4/PQQC family 10 220 8.8E-45 T 17-03-2017 IPR004305 Thiaminase-2/PQQC SHXM_RS07470 65bc11707463447290c3c52e86bb09c4 235 Gene3D G3DSA:1.20.910.10 5 226 1.6E-89 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS07470 65bc11707463447290c3c52e86bb09c4 235 Hamap MF_00654 Pyrroloquinoline-quinone synthase [pqqC]. 1 235 96.793 T 17-03-2017 IPR011845 Coenzyme PQQ biosynthesis protein C GO:0018189|GO:0055114 MetaCyc: PWY-6420 SHXM_RS07470 65bc11707463447290c3c52e86bb09c4 235 TIGRFAM TIGR02111 PQQ_syn_pqqC: coenzyme PQQ biosynthesis protein C 6 228 1.3E-83 T 17-03-2017 IPR011845 Coenzyme PQQ biosynthesis protein C GO:0018189|GO:0055114 MetaCyc: PWY-6420 SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 SUPERFAMILY SSF53335 28 193 1.13E-13 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 SUPERFAMILY SSF53335 283 315 1.13E-13 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 Gene3D G3DSA:3.40.50.150 52 145 1.2E-8 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 PIRSF PIRSF018005 4 321 8.9E-135 T 17-03-2017 IPR017804 Methyltransferase EgtD-like SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 TIGRFAM TIGR03438 egtD_ergothio: dimethylhistidine N-methyltransferase 19 317 4.5E-113 T 17-03-2017 IPR017804 Methyltransferase EgtD-like SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 Pfam PF10017 Histidine-specific methyltransferase, SAM-dependent 191 315 2.4E-41 T 17-03-2017 IPR019257 Histidine-specific methyltransferase, SAM-dependent SHXM_RS45010 d1485ab036d741c012cf39c53e9fca02 321 Hamap MF_02037 Histidine N-alpha-methyltransferase [egtD]. 6 320 53.874 T 17-03-2017 IPR032888 Histidine N-alpha-methyltransferase, Actinobacteria-type GO:0008276|GO:0052699 KEGG: 00340+2.1.1.44|MetaCyc: PWY-7255|MetaCyc: PWY-7550 SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 Pfam PF00069 Protein kinase domain 102 354 1.4E-45 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 SMART SM00220 102 359 1.6E-59 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 108 131 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 Gene3D G3DSA:1.10.510.10 172 355 4.2E-47 T 17-03-2017 SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 224 236 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 SUPERFAMILY SSF56112 89 356 4.13E-68 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS25450 8c7ec1f078291f8545688675128944d0 594 Gene3D G3DSA:3.30.200.20 94 171 1.7E-22 T 17-03-2017 SHXM_RS26065 678aac4ed038bb19116bf0d2b9139b51 310 SUPERFAMILY SSF53335 44 270 1.39E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26065 678aac4ed038bb19116bf0d2b9139b51 310 Pfam PF05050 Methyltransferase FkbM domain 96 262 5.2E-14 T 17-03-2017 IPR006342 Methyltransferase FkbM SHXM_RS26065 678aac4ed038bb19116bf0d2b9139b51 310 TIGRFAM TIGR01444 fkbM_fam: methyltransferase, FkbM family 93 232 3.9E-29 T 17-03-2017 IPR006342 Methyltransferase FkbM SHXM_RS26065 678aac4ed038bb19116bf0d2b9139b51 310 Gene3D G3DSA:3.40.50.150 75 271 6.5E-38 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Gene3D G3DSA:1.10.10.10 2 46 6.4E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Pfam PF01037 Lrp/AsnC ligand binding domain 64 131 2.6E-9 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Pfam PF13404 AsnC-type helix-turn-helix domain 2 42 1.7E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Pfam PF13404 AsnC-type helix-turn-helix domain 172 209 2.2E-9 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 SUPERFAMILY SSF54909 62 132 2.55E-10 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 SMART SM00344 170 273 0.0013 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 SMART SM00344 2 104 8.4E-8 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Gene3D G3DSA:1.10.10.10 171 215 6.3E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 ProSitePatterns PS00519 AsnC-type HTH domain signature. 186 212 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Gene3D G3DSA:3.30.70.920 231 308 6.8E-4 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 SUPERFAMILY SSF46785 2 47 8.67E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 SUPERFAMILY SSF54909 228 307 1.88E-5 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 184 195 1.7E-5 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 195 214 1.7E-5 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 168 184 1.7E-5 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 Gene3D G3DSA:3.30.70.920 62 131 3.2E-12 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS00020 c454ac1382a06e97f950cd756f3a8f85 331 SUPERFAMILY SSF46785 170 218 5.68E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22075 2209f4a301d8d8f40f010c93251c6e5a 343 SUPERFAMILY SSF48576 28 342 5.76E-78 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS22075 2209f4a301d8d8f40f010c93251c6e5a 343 Gene3D G3DSA:1.10.600.10 26 342 8.3E-86 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS22075 2209f4a301d8d8f40f010c93251c6e5a 343 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 221 233 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS22075 2209f4a301d8d8f40f010c93251c6e5a 343 Pfam PF00348 Polyprenyl synthetase 50 277 2.5E-58 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS08060 fd897747128cf3434b64034875d8fd06 177 Pfam PF01638 HxlR-like helix-turn-helix 20 104 9.7E-23 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS08060 fd897747128cf3434b64034875d8fd06 177 SUPERFAMILY SSF46785 7 144 1.18E-38 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08060 fd897747128cf3434b64034875d8fd06 177 Gene3D G3DSA:1.10.10.10 3 110 5.5E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22420 3b673d9e2a4e724a24228dd58bb1104e 385 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 148 254 1.8E-11 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS22420 3b673d9e2a4e724a24228dd58bb1104e 385 Gene3D G3DSA:3.40.50.720 4 158 4.5E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22420 3b673d9e2a4e724a24228dd58bb1104e 385 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 9 129 1.6E-23 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS22420 3b673d9e2a4e724a24228dd58bb1104e 385 SUPERFAMILY SSF51735 6 170 9.6E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22420 3b673d9e2a4e724a24228dd58bb1104e 385 Gene3D G3DSA:3.30.360.10 159 355 1.8E-41 T 17-03-2017 SHXM_RS22420 3b673d9e2a4e724a24228dd58bb1104e 385 SUPERFAMILY SSF55347 145 282 1.59E-29 T 17-03-2017 SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 Gene3D G3DSA:3.40.50.720 1 248 2.4E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 246 1.1E-53 T 17-03-2017 SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 85 96 4.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 4.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 4.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 2.4E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 2.4E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 2.4E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 2.4E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 2.4E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 2.4E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 SUPERFAMILY SSF51735 6 247 1.27E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13775 bce3ef3e616537e66bf19f7d62d6fe01 254 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS10000 8399bc557463e492b0c5afc56321c54a 554 SUPERFAMILY SSF52540 132 511 5.18E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10000 8399bc557463e492b0c5afc56321c54a 554 Pfam PF12696 TraM recognition site of TraD and TraG 419 482 1.2E-5 T 17-03-2017 IPR032689 TraD/TraG, TraM recognition site SHXM_RS10000 8399bc557463e492b0c5afc56321c54a 554 Pfam PF01935 Domain of unknown function DUF87 155 232 4.3E-7 T 17-03-2017 IPR002789 Helicase HerA, central domain SHXM_RS10000 8399bc557463e492b0c5afc56321c54a 554 Gene3D G3DSA:3.40.50.300 147 236 3.3E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10000 8399bc557463e492b0c5afc56321c54a 554 Gene3D G3DSA:3.40.50.300 363 509 3.3E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 Gene3D G3DSA:1.10.630.10 41 424 1.8E-111 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 Pfam PF00067 Cytochrome P450 235 394 6.3E-22 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 366 375 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 181 196 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 373 384 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 364 373 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 164 180 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 117 128 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 315 342 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 297 308 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 343 358 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00359 B-class P450 signature 218 240 1.1E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 SUPERFAMILY SSF48264 46 423 1.44E-89 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00385 P450 superfamily signature 373 384 8.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00385 P450 superfamily signature 262 279 8.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00385 P450 superfamily signature 364 373 8.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27100 3e6fa01174f70d768c96f989248e0eb4 425 PRINTS PR00385 P450 superfamily signature 297 308 8.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 Gene3D G3DSA:3.40.50.720 198 316 2.6E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 Pfam PF00107 Zinc-binding dehydrogenase 205 330 4.3E-25 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 36 126 4.9E-24 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 SUPERFAMILY SSF51735 167 338 4.14E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 68 82 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 SUPERFAMILY SSF50129 11 201 1.98E-55 T 17-03-2017 IPR011032 GroES-like SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 SMART SM00829 18 371 7.7E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 SUPERFAMILY SSF50129 324 371 5.65E-5 T 17-03-2017 IPR011032 GroES-like SHXM_RS40700 c7c422743173d61f6fa51426ec009280 379 Gene3D G3DSA:3.90.180.10 11 197 4.1E-53 T 17-03-2017 IPR011032 GroES-like SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 Gene3D G3DSA:3.40.50.720 2 150 9.9E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 SUPERFAMILY SSF51735 5 160 1.47E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 ProSitePatterns PS01042 Homoserine dehydrogenase signature. 185 207 - T 17-03-2017 IPR019811 Homoserine dehydrogenase, conserved site GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 Pfam PF00742 Homoserine dehydrogenase 139 319 3.5E-67 T 17-03-2017 IPR001342 Homoserine dehydrogenase, catalytic GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 PIRSF PIRSF000098 4 430 4.3E-156 T 17-03-2017 IPR016204 Homoserine dehydrogenase GO:0004412|GO:0006520|GO:0055114 KEGG: 00260+1.1.1.3|KEGG: 00270+1.1.1.3|KEGG: 00300+1.1.1.3 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 SUPERFAMILY SSF55021 350 422 3.05E-15 T 17-03-2017 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 Gene3D G3DSA:3.30.360.10 151 303 4.2E-55 T 17-03-2017 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 SUPERFAMILY SSF55347 139 306 3.33E-53 T 17-03-2017 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 Pfam PF03447 Homoserine dehydrogenase, NAD binding domain 13 131 3.3E-20 T 17-03-2017 IPR005106 Aspartate/homoserine dehydrogenase, NAD-binding GO:0016491|GO:0050661|GO:0055114 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 Pfam PF01842 ACT domain 354 415 1.2E-13 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS35165 1e3d03da412aa9bdabeff827a868a804 430 Gene3D G3DSA:3.30.70.260 351 421 5.7E-13 T 17-03-2017 SHXM_RS32550 2b59719fd36191a028a9ad5ace6980b3 190 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 58 3.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32550 2b59719fd36191a028a9ad5ace6980b3 190 SUPERFAMILY SSF46689 2 70 3.94E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS32550 2b59719fd36191a028a9ad5ace6980b3 190 Gene3D G3DSA:1.10.357.10 56 186 1.5E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32550 2b59719fd36191a028a9ad5ace6980b3 190 Pfam PF16859 Bacterial transcriptional repressor C-terminal 73 182 3.1E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32550 2b59719fd36191a028a9ad5ace6980b3 190 SUPERFAMILY SSF48498 75 185 1.57E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32550 2b59719fd36191a028a9ad5ace6980b3 190 Gene3D G3DSA:1.10.10.60 2 55 1.1E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46295 4193657be69971ef443a65b82acf5bc3 330 Gene3D G3DSA:1.10.10.10 262 316 8.4E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46295 4193657be69971ef443a65b82acf5bc3 330 SUPERFAMILY SSF46785 262 315 3.79E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46295 4193657be69971ef443a65b82acf5bc3 330 Pfam PF12840 Helix-turn-helix domain 262 309 2.8E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 SUPERFAMILY SSF51998 158 593 1.5E-131 T 17-03-2017 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 SUPERFAMILY SSF51998 627 701 1.5E-131 T 17-03-2017 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 Pfam PF08471 Class II vitamin B12-dependent ribonucleotide reductase 54 137 9.5E-19 T 17-03-2017 IPR013678 Ribonucleotide reductase class II vitamin B12-dependent, N-terminal domain GO:0004748|GO:0050897|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 TIGRFAM TIGR02504 NrdJ_Z: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent 95 707 7.8E-188 T 17-03-2017 IPR013344 Ribonucleotide reductase, adenosylcobalamin-dependent GO:0000166|GO:0004748|GO:0031419|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 Gene3D G3DSA:3.20.70.20 68 484 3.4E-99 T 17-03-2017 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 Gene3D G3DSA:3.20.70.20 543 589 3.4E-99 T 17-03-2017 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 Gene3D G3DSA:3.20.70.20 656 701 3.4E-99 T 17-03-2017 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 PRINTS PR01183 Ribonucleotide reductase large chain signature 233 252 3.3E-16 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 PRINTS PR01183 Ribonucleotide reductase large chain signature 436 458 3.3E-16 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 PRINTS PR01183 Ribonucleotide reductase large chain signature 360 371 3.3E-16 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 PRINTS PR01183 Ribonucleotide reductase large chain signature 464 487 3.3E-16 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 PRINTS PR01183 Ribonucleotide reductase large chain signature 398 421 3.3E-16 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 PRINTS PR01183 Ribonucleotide reductase large chain signature 543 570 3.3E-16 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS37395 f1fa8ac619270c84d7baa264fc6c810f 953 Pfam PF02867 Ribonucleotide reductase, barrel domain 158 697 1.6E-147 T 17-03-2017 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 PIRSF PIRSF001220 33 369 9.9E-76 T 17-03-2017 IPR006034 Asparaginase/glutaminase GO:0006520 Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 Gene3D G3DSA:3.40.50.40 257 364 9.2E-32 T 17-03-2017 IPR027473 L-asparaginase, C-terminal domain Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 PRINTS PR00139 Asparaginase/glutaminase family signature 304 322 3.6E-18 T 17-03-2017 IPR006034 Asparaginase/glutaminase GO:0006520 Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 PRINTS PR00139 Asparaginase/glutaminase family signature 39 50 3.6E-18 T 17-03-2017 IPR006034 Asparaginase/glutaminase GO:0006520 Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 PRINTS PR00139 Asparaginase/glutaminase family signature 118 136 3.6E-18 T 17-03-2017 IPR006034 Asparaginase/glutaminase GO:0006520 Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 PIRSF PIRSF500176 35 368 4.1E-71 T 17-03-2017 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 SUPERFAMILY SSF53774 34 371 2.36E-83 T 17-03-2017 IPR006034 Asparaginase/glutaminase GO:0006520 Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 Pfam PF00710 Asparaginase, N-terminal 38 231 8.1E-49 T 17-03-2017 IPR027474 L-asparaginase, N-terminal Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 Gene3D G3DSA:3.40.50.1170 35 243 6.7E-57 T 17-03-2017 IPR027474 L-asparaginase, N-terminal Reactome: R-HSA-70614 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 ProSitePatterns PS00144 Asparaginase / glutaminase active site signature 1. 41 49 - T 17-03-2017 IPR020827 Asparaginase/glutaminase, active site 1 GO:0006520 SHXM_RS08305 126237f92aeb8298b3591a14028c90a6 374 SMART SM00870 38 359 1.0E-97 T 17-03-2017 IPR006034 Asparaginase/glutaminase GO:0006520 Reactome: R-HSA-70614 SHXM_RS06700 56cb7d235627101aa9c6e9c62df3ac49 96 SUPERFAMILY SSF143212 2 79 1.7E-24 T 17-03-2017 SHXM_RS06700 56cb7d235627101aa9c6e9c62df3ac49 96 ProDom PD280340 RV1738/MT1780 MB2665C MB1767 SCO3163 RV2632C/MT2708 4 79 5.0E-12 T 17-03-2017 IPR015057 Protein of unknown function DUF1876 SHXM_RS06700 56cb7d235627101aa9c6e9c62df3ac49 96 Pfam PF08962 Domain of unknown function (DUF1876) 6 83 2.2E-30 T 17-03-2017 IPR015057 Protein of unknown function DUF1876 SHXM_RS46500 d7bfa534d9d880e95f691fb7c5ed9aa6 289 Pfam PF01061 ABC-2 type transporter 46 255 1.2E-34 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS46500 d7bfa534d9d880e95f691fb7c5ed9aa6 289 PIRSF PIRSF006648 20 287 8.2E-62 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS46500 d7bfa534d9d880e95f691fb7c5ed9aa6 289 PRINTS PR00164 ABC-2 type transport system membrane protein signature 93 115 6.6E-8 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS46500 d7bfa534d9d880e95f691fb7c5ed9aa6 289 PRINTS PR00164 ABC-2 type transport system membrane protein signature 213 232 6.6E-8 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS46500 d7bfa534d9d880e95f691fb7c5ed9aa6 289 PRINTS PR00164 ABC-2 type transport system membrane protein signature 176 200 6.6E-8 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS46500 d7bfa534d9d880e95f691fb7c5ed9aa6 289 PRINTS PR00164 ABC-2 type transport system membrane protein signature 233 252 6.6E-8 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS45745 2a114a29e868e7ca0e84969d1e0dd5da 295 SUPERFAMILY SSF51658 30 276 5.91E-34 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45745 2a114a29e868e7ca0e84969d1e0dd5da 295 Pfam PF01261 Xylose isomerase-like TIM barrel 40 221 1.5E-20 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45745 2a114a29e868e7ca0e84969d1e0dd5da 295 Gene3D G3DSA:3.20.20.150 5 293 1.6E-48 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 74 302 1.3E-45 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 Gene3D G3DSA:3.40.190.10 187 259 1.2E-11 T 17-03-2017 SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 Gene3D G3DSA:3.40.190.10 21 28 1.9E-29 T 17-03-2017 SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 Gene3D G3DSA:3.40.190.10 62 186 1.9E-29 T 17-03-2017 SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 SMART SM00062 73 304 6.0E-34 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 SUPERFAMILY SSF53850 12 27 1.79E-51 T 17-03-2017 SHXM_RS45710 a4b491baeea70bc5e231dc786fdca934 320 SUPERFAMILY SSF53850 65 302 1.79E-51 T 17-03-2017 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 Gene3D G3DSA:3.90.79.10 250 359 1.5E-23 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 Gene3D G3DSA:3.40.50.150 45 209 7.6E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 SUPERFAMILY SSF53335 44 212 1.0E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 ProSitePatterns PS00893 Nudix box signature. 278 299 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 Pfam PF13649 Methyltransferase domain 54 144 8.2E-12 T 17-03-2017 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 Pfam PF00293 NUDIX domain 251 359 1.5E-16 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 PRINTS PR00502 NUDIX hydrolase family signature 287 302 6.0E-6 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 PRINTS PR00502 NUDIX hydrolase family signature 273 287 6.0E-6 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS40155 78a1d52a2e4b17a0ad5dbd303d877972 400 SUPERFAMILY SSF55811 230 360 1.29E-24 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 SUPERFAMILY SSF51735 7 170 5.17E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 SUPERFAMILY SSF55347 143 295 1.62E-29 T 17-03-2017 SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 Gene3D G3DSA:3.30.360.10 302 351 1.8E-41 T 17-03-2017 SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 Gene3D G3DSA:3.30.360.10 157 267 1.8E-41 T 17-03-2017 SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 147 252 6.2E-11 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 Gene3D G3DSA:3.40.50.720 6 156 6.4E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01795 1b23c8421ec38e9ccf1fc8b1c9959359 382 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 10 121 3.5E-17 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 Gene3D G3DSA:3.40.50.720 1 252 1.4E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 149 177 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 80 91 1.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 1.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 162 181 1.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 SUPERFAMILY SSF51735 1 253 5.41E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 198 6.8E-5 T 17-03-2017 SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 Pfam PF00106 short chain dehydrogenase 7 203 3.8E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 183 200 9.6E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 9.6E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 181 9.6E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 9.6E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 9.6E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01135 bc6fe9480fef4cdbc67ddb2e121fed02 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 9.6E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24845 07eb538394112d4eb5082305fad3eff7 140 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 17 105 4.1E-10 T 17-03-2017 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SHXM_RS24845 07eb538394112d4eb5082305fad3eff7 140 Gene3D G3DSA:3.40.140.10 6 134 2.2E-42 T 17-03-2017 SHXM_RS24845 07eb538394112d4eb5082305fad3eff7 140 SUPERFAMILY SSF53927 10 133 1.55E-38 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 Pfam PF00005 ABC transporter 78 229 1.7E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 282 348 3.0E-16 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 ProSitePatterns PS00211 ABC transporters family signature. 202 216 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 SMART SM00382 86 279 6.3E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 280 357 7.3E-23 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 Gene3D G3DSA:3.40.50.300 48 303 8.9E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33865 66b1edd057e3458bbeadad982e3fb019 385 SUPERFAMILY SSF52540 49 301 2.48E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 Pfam PF01614 Bacterial transcriptional regulator 133 249 4.5E-21 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 Gene3D G3DSA:3.30.450.40 83 250 2.3E-43 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 Pfam PF09339 IclR helix-turn-helix domain 13 63 3.7E-13 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 SUPERFAMILY SSF46785 10 84 4.26E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 SUPERFAMILY SSF55781 82 250 1.24E-41 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 SMART SM00346 10 101 2.2E-12 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS13635 5675931aed979726680dc2f3ed3c0387 264 Gene3D G3DSA:1.10.10.10 10 82 4.6E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02120 ece4b0f348197bb81e101588559eeba2 317 Gene3D G3DSA:3.10.129.10 29 128 6.7E-5 T 17-03-2017 IPR029069 HotDog domain SHXM_RS02120 ece4b0f348197bb81e101588559eeba2 317 Pfam PF13279 Thioesterase-like superfamily 187 293 7.9E-6 T 17-03-2017 SHXM_RS02120 ece4b0f348197bb81e101588559eeba2 317 SUPERFAMILY SSF54637 175 283 2.53E-9 T 17-03-2017 IPR029069 HotDog domain SHXM_RS02120 ece4b0f348197bb81e101588559eeba2 317 Gene3D G3DSA:3.10.129.10 180 283 2.1E-5 T 17-03-2017 IPR029069 HotDog domain SHXM_RS43125 7db40f9f7c1f3b9adbf9175b65a5f537 168 Gene3D G3DSA:2.30.110.10 14 164 7.5E-53 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS43125 7db40f9f7c1f3b9adbf9175b65a5f537 168 Pfam PF01613 Flavin reductase like domain 22 166 1.3E-35 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS43125 7db40f9f7c1f3b9adbf9175b65a5f537 168 SMART SM00903 22 165 8.8E-50 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS43125 7db40f9f7c1f3b9adbf9175b65a5f537 168 SUPERFAMILY SSF50475 16 164 1.18E-41 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41445 18254b8c168ba64bb155eff2cc1926f1 100 SUPERFAMILY SSF56281 2 60 2.84E-8 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41445 18254b8c168ba64bb155eff2cc1926f1 100 Pfam PF00753 Metallo-beta-lactamase superfamily 3 55 2.3E-8 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41445 18254b8c168ba64bb155eff2cc1926f1 100 Gene3D G3DSA:3.60.15.10 2 44 1.4E-7 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Pfam PF13191 AAA ATPase domain 14 183 6.4E-24 T 17-03-2017 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SUPERFAMILY SSF46894 880 945 1.33E-14 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Gene3D G3DSA:3.40.50.300 129 190 1.1E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Gene3D G3DSA:3.40.50.300 13 83 1.1E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SUPERFAMILY SSF48452 751 857 1.64E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SUPERFAMILY SSF48452 595 704 1.64E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SMART SM00421 888 945 4.3E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SUPERFAMILY SSF48452 397 518 3.04E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Pfam PF00196 Bacterial regulatory proteins, luxR family 890 944 1.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Gene3D G3DSA:1.25.40.10 397 532 8.4E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Gene3D G3DSA:1.25.40.10 823 859 3.7E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Gene3D G3DSA:1.25.40.10 605 780 3.7E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 Gene3D G3DSA:1.10.10.10 885 944 2.0E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SUPERFAMILY SSF52540 8 86 9.25E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 SUPERFAMILY SSF52540 148 262 9.25E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 905 921 2.0E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 891 905 2.0E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 921 933 2.0E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44885 73cc0dc1c2b4f27409366a646dbae254 966 ProSitePatterns PS00622 LuxR-type HTH domain signature. 905 932 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 Pfam PF02565 Recombination protein O C terminal 92 245 4.1E-34 T 17-03-2017 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 SUPERFAMILY SSF57863 90 239 1.31E-39 T 17-03-2017 SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 Pfam PF11967 Recombination protein O N terminal 1 86 1.8E-27 T 17-03-2017 IPR022572 DNA replication/recombination mediator RecO, N-terminal SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 Hamap MF_00201 DNA repair protein RecO [recO]. 2 249 26.106 T 17-03-2017 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 Gene3D G3DSA:2.40.50.140 1 87 2.2E-34 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 SUPERFAMILY SSF50249 1 69 1.18E-17 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS21090 1f199595947435cab22fdb2fc5b46dd2 249 TIGRFAM TIGR00613 reco: DNA repair protein RecO 5 205 2.4E-33 T 17-03-2017 IPR003717 Recombination protein O, RecO GO:0006281|GO:0006310 SHXM_RS29835 d16f37474483e60b7e147bbfac26b724 437 Gene3D G3DSA:1.20.1250.20 14 181 4.3E-19 T 17-03-2017 SHXM_RS29835 d16f37474483e60b7e147bbfac26b724 437 Pfam PF07690 Major Facilitator Superfamily 15 250 1.8E-16 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS29835 d16f37474483e60b7e147bbfac26b724 437 Pfam PF07690 Major Facilitator Superfamily 252 399 2.4E-11 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS29835 d16f37474483e60b7e147bbfac26b724 437 Gene3D G3DSA:1.20.1250.20 223 401 3.3E-15 T 17-03-2017 SHXM_RS29835 d16f37474483e60b7e147bbfac26b724 437 SUPERFAMILY SSF103473 12 404 1.22E-42 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS25810 646a0a438bb41b1513c4be7c9807c5bb 223 Gene3D G3DSA:1.10.3210.10 46 151 2.9E-9 T 17-03-2017 IPR006674 HD domain SHXM_RS25810 646a0a438bb41b1513c4be7c9807c5bb 223 SUPERFAMILY SSF109604 37 212 1.88E-28 T 17-03-2017 SHXM_RS25810 646a0a438bb41b1513c4be7c9807c5bb 223 PIRSF PIRSF035170 6 223 4.5E-68 T 17-03-2017 IPR009218 Predicted HD phosphohydrolase SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 155 175 3.1E-42 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 196 213 3.1E-42 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 18 35 3.1E-42 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 132 154 3.1E-42 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 238 256 3.1E-42 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 91 112 3.1E-42 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 Gene3D G3DSA:2.120.10.30 9 287 2.7E-79 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 17 257 3.8E-78 T 17-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region SHXM_RS20465 e0037653f655dea3bcc456a786d8f967 288 SUPERFAMILY SSF63829 10 285 2.42E-60 T 17-03-2017 SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 SUPERFAMILY SSF48452 713 829 5.06E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 Gene3D G3DSA:3.40.50.300 301 340 1.7E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 Pfam PF00931 NB-ARC domain 312 472 7.8E-11 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 Gene3D G3DSA:1.25.40.10 718 834 1.2E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 Gene3D G3DSA:3.40.50.300 341 377 7.7E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 Gene3D G3DSA:3.40.50.300 431 475 7.7E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34840 6e8fd6508a9c6ba8df4102a3bba20088 1101 SUPERFAMILY SSF52540 297 506 8.33E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39445 42ac21f579eb16723e9fcc3a80aa3a68 285 SUPERFAMILY SSF53067 145 264 4.65E-9 T 17-03-2017 SHXM_RS39445 42ac21f579eb16723e9fcc3a80aa3a68 285 SUPERFAMILY SSF53067 29 138 8.91E-5 T 17-03-2017 SHXM_RS39445 42ac21f579eb16723e9fcc3a80aa3a68 285 Gene3D G3DSA:3.30.420.40 29 152 5.4E-9 T 17-03-2017 SHXM_RS39445 42ac21f579eb16723e9fcc3a80aa3a68 285 Pfam PF06723 MreB/Mbl protein 61 165 5.5E-7 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS39445 42ac21f579eb16723e9fcc3a80aa3a68 285 Pfam PF06723 MreB/Mbl protein 189 265 2.2E-6 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS39445 42ac21f579eb16723e9fcc3a80aa3a68 285 Gene3D G3DSA:3.30.420.40 153 247 8.0E-10 T 17-03-2017 SHXM_RS23780 a774037d63ad5cb94cf0177bc8ea35b1 306 SUPERFAMILY SSF161098 58 292 1.7E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23780 a774037d63ad5cb94cf0177bc8ea35b1 306 Gene3D G3DSA:1.10.3720.10 11 294 3.8E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23780 a774037d63ad5cb94cf0177bc8ea35b1 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 104 300 1.0E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14155 7a2766a9a5b74d6402150feb8bd7373f 295 Gene3D G3DSA:3.20.20.140 4 255 2.0E-35 T 17-03-2017 SHXM_RS14155 7a2766a9a5b74d6402150feb8bd7373f 295 PIRSF PIRSF005295 2 259 8.9E-103 T 17-03-2017 IPR012022 Protein of unknown function UCP005295 SHXM_RS14155 7a2766a9a5b74d6402150feb8bd7373f 295 SUPERFAMILY SSF51556 2 256 1.3E-51 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS14155 7a2766a9a5b74d6402150feb8bd7373f 295 Pfam PF01026 TatD related DNase 4 226 2.2E-11 T 17-03-2017 IPR001130 TatD family GO:0016788 SHXM_RS16200 04e06c909b6c27c25a693511e4612521 332 SUPERFAMILY SSF51735 125 285 1.6E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16200 04e06c909b6c27c25a693511e4612521 332 Gene3D G3DSA:3.40.50.720 152 255 4.3E-14 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16200 04e06c909b6c27c25a693511e4612521 332 SUPERFAMILY SSF50129 4 155 3.71E-17 T 17-03-2017 IPR011032 GroES-like SHXM_RS16200 04e06c909b6c27c25a693511e4612521 332 Gene3D G3DSA:3.90.180.10 2 57 1.1E-5 T 17-03-2017 IPR011032 GroES-like SHXM_RS16200 04e06c909b6c27c25a693511e4612521 332 Gene3D G3DSA:3.90.180.10 105 151 4.7E-5 T 17-03-2017 IPR011032 GroES-like SHXM_RS04475 6de9471bd9f7bec129520ca1455387df 248 SUPERFAMILY SSF46689 33 99 3.64E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04475 6de9471bd9f7bec129520ca1455387df 248 SUPERFAMILY SSF48498 107 246 7.78E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS04475 6de9471bd9f7bec129520ca1455387df 248 Gene3D G3DSA:1.10.10.60 28 93 1.1E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04475 6de9471bd9f7bec129520ca1455387df 248 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 103 246 2.1E-19 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS04475 6de9471bd9f7bec129520ca1455387df 248 Pfam PF00440 Bacterial regulatory proteins, tetR family 45 89 3.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04475 6de9471bd9f7bec129520ca1455387df 248 Gene3D G3DSA:1.10.357.10 94 246 1.6E-30 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS23040 37096fdf83a0c8e12c138e9ce5dd3209 309 Pfam PF12146 Serine aminopeptidase, S33 78 200 1.6E-8 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS23040 37096fdf83a0c8e12c138e9ce5dd3209 309 SUPERFAMILY SSF53474 31 309 2.11E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23040 37096fdf83a0c8e12c138e9ce5dd3209 309 Gene3D G3DSA:3.40.50.1820 51 191 1.2E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23040 37096fdf83a0c8e12c138e9ce5dd3209 309 Gene3D G3DSA:3.40.50.1820 238 308 1.2E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49780 f368658fb28b979ea543d03b1c5a89a1 330 Gene3D G3DSA:2.60.120.330 132 272 1.2E-21 T 17-03-2017 IPR027443 Isopenicillin N synthase-like SHXM_RS49780 f368658fb28b979ea543d03b1c5a89a1 330 SUPERFAMILY SSF51197 108 272 9.61E-21 T 17-03-2017 SHXM_RS49780 f368658fb28b979ea543d03b1c5a89a1 330 Pfam PF03171 2OG-Fe(II) oxygenase superfamily 183 267 2.4E-9 T 17-03-2017 IPR005123 Oxoglutarate/iron-dependent dioxygenase GO:0016491|GO:0055114 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 Gene3D G3DSA:3.20.110.10 202 521 2.2E-86 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 SMART SM00872 519 598 4.0E-37 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 SUPERFAMILY SSF74650 623 1050 2.57E-69 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 Pfam PF09261 Alpha mannosidase middle domain 519 597 5.7E-27 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 659 1048 5.6E-71 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 254 504 1.0E-83 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 SUPERFAMILY SSF88713 247 517 3.25E-72 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 SUPERFAMILY SSF88688 518 618 9.81E-26 T 17-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain SHXM_RS38825 2ded932ef8456f06e100a0a84b6dbe6c 1054 Gene3D G3DSA:1.20.1270.50 522 617 1.3E-22 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 Pfam PF00106 short chain dehydrogenase 29 228 3.9E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 SUPERFAMILY SSF51735 26 278 2.76E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 Gene3D G3DSA:3.40.50.720 24 274 4.1E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 103 114 7.9E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 165 7.9E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 209 226 7.9E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 30 47 7.9E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47520 0e5bd0ba86f5ba0bc6c69eebf4019369 316 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 188 207 7.9E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39795 f164e4a8a1dd8ea904f3d908b8c242cd 77 Gene3D G3DSA:3.10.450.50 1 56 4.3E-4 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06335 a841b530161476f20cb274e4d479273b 301 Gene3D G3DSA:3.30.2010.10 114 190 2.8E-14 T 17-03-2017 SHXM_RS06335 a841b530161476f20cb274e4d479273b 301 Pfam PF01435 Peptidase family M48 112 201 3.9E-11 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS26885 c1914b9677542ca44364002af3a3b900 812 Pfam PF03030 Inorganic H+ pyrophosphatase 37 750 9.2E-235 T 17-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SHXM_RS26885 c1914b9677542ca44364002af3a3b900 812 Hamap MF_01129 Putative K(+)-stimulated pyrophosphate-energized sodium pump [hppA]. 26 755 24.395 T 17-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SHXM_RS26885 c1914b9677542ca44364002af3a3b900 812 PIRSF PIRSF001265 21 763 3.1E-259 T 17-03-2017 IPR004131 Pyrophosphate-energised proton pump GO:0004427|GO:0009678|GO:0015992|GO:0016020 KEGG: 00190+3.6.1.1 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 SMART SM00342 223 306 6.2E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 260 302 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 Pfam PF12833 Helix-turn-helix domain 229 308 8.2E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 SUPERFAMILY SSF52317 2 187 2.23E-48 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 Gene3D G3DSA:3.40.50.880 2 209 2.0E-58 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 SUPERFAMILY SSF46689 259 311 1.61E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 Gene3D G3DSA:1.10.10.60 210 260 1.0E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 SUPERFAMILY SSF46689 206 256 3.05E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 Gene3D G3DSA:1.10.10.60 261 311 3.5E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46355 26f2305afaf5c06347f114a4f8b30262 321 Pfam PF01965 DJ-1/PfpI family 2 168 7.1E-26 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 SUPERFAMILY SSF55781 68 254 5.1E-35 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 SMART SM00346 11 100 1.7E-11 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 Gene3D G3DSA:1.10.10.10 15 77 7.0E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 Gene3D G3DSA:3.30.450.40 78 255 8.7E-38 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 Pfam PF01614 Bacterial transcriptional regulator 131 250 5.8E-20 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 SUPERFAMILY SSF46785 16 82 1.19E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00350 76a21ac49d90cbb7219adba78f0a2d84 258 Pfam PF09339 IclR helix-turn-helix domain 17 62 4.0E-13 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS20030 4209fd170341157f19f097cc06cb5804 714 SMART SM00458 23 162 1.1E-13 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS20030 4209fd170341157f19f097cc06cb5804 714 Pfam PF00652 Ricin-type beta-trefoil lectin domain 30 159 5.3E-22 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS20030 4209fd170341157f19f097cc06cb5804 714 SUPERFAMILY SSF50370 22 160 4.46E-39 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS20030 4209fd170341157f19f097cc06cb5804 714 Gene3D G3DSA:2.80.10.50 30 161 3.5E-36 T 17-03-2017 SHXM_RS20030 4209fd170341157f19f097cc06cb5804 714 SUPERFAMILY SSF51126 539 641 4.65E-6 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20030 4209fd170341157f19f097cc06cb5804 714 SUPERFAMILY SSF51126 427 491 4.65E-6 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 Pfam PF04972 BON domain 146 210 1.8E-13 T 17-03-2017 IPR007055 BON domain SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 PIRSF PIRSF036990 6 220 8.5E-66 T 17-03-2017 IPR017080 Uncharacterised conserved protein UCP036990, CBS, BON SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 Pfam PF00571 CBS domain 8 59 1.0E-9 T 17-03-2017 IPR000644 CBS domain SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 Pfam PF00571 CBS domain 90 143 2.5E-15 T 17-03-2017 IPR000644 CBS domain SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 SUPERFAMILY SSF54631 6 146 2.17E-33 T 17-03-2017 SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 Gene3D G3DSA:3.20.20.70 8 146 3.1E-30 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 SMART SM00116 96 144 6.1E-14 T 17-03-2017 IPR000644 CBS domain SHXM_RS43490 1a1c61e1902b0de745c42439a01cc5bd 221 SMART SM00116 15 63 1.5 T 17-03-2017 IPR000644 CBS domain SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 SUPERFAMILY SSF51182 47 121 3.3E-5 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 Pfam PF12833 Helix-turn-helix domain 261 338 3.9E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 240 284 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 SUPERFAMILY SSF46689 238 288 2.6E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 Gene3D G3DSA:2.60.120.10 78 118 1.4E-4 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 Gene3D G3DSA:1.10.10.60 292 342 6.0E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 SUPERFAMILY SSF46689 291 341 4.3E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 Pfam PF12852 Cupin 35 223 1.4E-29 T 17-03-2017 IPR032783 AraC-type transcription regulator, ligand-binding domain SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 SMART SM00342 255 338 4.6E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS11465 3b2a61d09f84dbf8781d40c57955c0ab 350 Gene3D G3DSA:1.10.10.60 236 291 5.4E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 Gene3D G3DSA:3.40.50.300 1 156 6.3E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 PRINTS PR01100 Shikimate kinase family signature 85 102 8.9E-6 T 17-03-2017 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 PRINTS PR01100 Shikimate kinase family signature 65 74 8.9E-6 T 17-03-2017 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 PRINTS PR01100 Shikimate kinase family signature 19 32 8.9E-6 T 17-03-2017 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 PRINTS PR01100 Shikimate kinase family signature 47 55 8.9E-6 T 17-03-2017 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 Pfam PF01202 Shikimate kinase 1 155 1.7E-41 T 17-03-2017 IPR031322 Shikimate kinase/gluconokinase KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 ProSitePatterns PS01128 Shikimate kinase signature. 48 73 - T 17-03-2017 IPR023000 Shikimate kinase, conserved site KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 Hamap MF_00109 Shikimate kinase [aroK]. 1 156 21.853 T 17-03-2017 IPR000623 Shikimate kinase/Threonine synthase-like 1 KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 SHXM_RS12415 c1bbecf2d366e2857e8a63775205c7d6 160 SUPERFAMILY SSF52540 1 155 3.82E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 ProSitePatterns PS00069 Glucose-6-phosphate dehydrogenase active site. 198 204 - T 17-03-2017 IPR019796 Glucose-6-phosphate dehydrogenase, active site GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 Pfam PF02781 Glucose-6-phosphate dehydrogenase, C-terminal domain 210 505 1.7E-116 T 17-03-2017 IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 240 257 2.2E-47 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 164 177 2.2E-47 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 258 274 2.2E-47 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 188 216 2.2E-47 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 PRINTS PR00079 Glucose-6-phosphate dehydrogenase signature 347 373 2.2E-47 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 TIGRFAM TIGR00871 zwf: glucose-6-phosphate dehydrogenase 23 506 1.7E-200 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 Pfam PF00479 Glucose-6-phosphate dehydrogenase, NAD binding domain 25 208 3.7E-61 T 17-03-2017 IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding GO:0004345|GO:0006006|GO:0050661|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 Hamap MF_00966 Glucose-6-phosphate 1-dehydrogenase [zwf]. 21 506 87.693 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 SUPERFAMILY SSF55347 198 505 4.58E-115 T 17-03-2017 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 PIRSF PIRSF000110 9 507 1.2E-181 T 17-03-2017 IPR001282 Glucose-6-phosphate dehydrogenase GO:0004345|GO:0006006|GO:0055114 KEGG: 00030+1.1.1.49|KEGG: 00480+1.1.1.49|MetaCyc: PWY-7268 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 Gene3D G3DSA:3.40.50.720 21 207 1.4E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 Gene3D G3DSA:3.30.360.10 208 505 2.2E-123 T 17-03-2017 SHXM_RS17880 b751282a26aec62faa17a5718991fcaf 507 SUPERFAMILY SSF51735 11 211 1.06E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 SUPERFAMILY SSF88659 100 159 8.37E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 Pfam PF08281 Sigma-70, region 4 107 156 5.5E-12 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 SUPERFAMILY SSF88946 3 81 1.92E-13 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 159 5.1E-17 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 Gene3D G3DSA:1.10.1740.10 3 90 6.0E-13 T 17-03-2017 SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 Gene3D G3DSA:1.10.10.10 103 160 8.7E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20740 4f263ed9c3c580aac0216bcd08f48035 219 Pfam PF04542 Sigma-70 region 2 10 74 3.3E-7 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 SMART SM00345 15 73 2.0E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 Pfam PF07729 FCD domain 87 206 1.0E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 Gene3D G3DSA:1.20.120.530 78 221 1.0E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 73 6.7E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 33 47 1.1E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 47 63 1.1E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 Gene3D G3DSA:1.10.10.10 4 74 6.8E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 SMART SM00895 83 207 1.4E-15 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 SUPERFAMILY SSF46785 6 77 6.69E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44775 dfb6939985e7bd22f8a12253cc4479d1 246 SUPERFAMILY SSF48008 80 212 8.89E-24 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06375 3b7411aa8782bf920f777391ce5f5935 465 Gene3D G3DSA:3.40.630.10 16 71 5.5E-24 T 17-03-2017 SHXM_RS06375 3b7411aa8782bf920f777391ce5f5935 465 Gene3D G3DSA:3.40.630.10 240 446 5.5E-24 T 17-03-2017 SHXM_RS06375 3b7411aa8782bf920f777391ce5f5935 465 SUPERFAMILY SSF53187 233 445 1.71E-23 T 17-03-2017 SHXM_RS06375 3b7411aa8782bf920f777391ce5f5935 465 SUPERFAMILY SSF53187 4 67 1.71E-23 T 17-03-2017 SHXM_RS06375 3b7411aa8782bf920f777391ce5f5935 465 Pfam PF04389 Peptidase family M28 241 432 4.2E-10 T 17-03-2017 IPR007484 Peptidase M28 SHXM_RS43210 59bcf7c1a7aed619aa7fd0e35f3d55a5 409 SUPERFAMILY SSF55874 285 401 7.62E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43210 59bcf7c1a7aed619aa7fd0e35f3d55a5 409 Pfam PF07730 Histidine kinase 202 267 1.8E-20 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS02390 cc15a17c11968f6c4d0dcdf3d18f6e58 316 Gene3D G3DSA:1.10.3720.10 89 307 1.8E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02390 cc15a17c11968f6c4d0dcdf3d18f6e58 316 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 312 4.8E-33 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02390 cc15a17c11968f6c4d0dcdf3d18f6e58 316 SUPERFAMILY SSF161098 89 298 2.75E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12845 da94929a99085ddad533bf180b3e76a3 173 SUPERFAMILY SSF88659 85 160 2.06E-8 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS12845 da94929a99085ddad533bf180b3e76a3 173 Gene3D G3DSA:1.10.10.10 95 159 9.3E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31315 844ea57bedaac6324787065dcf2ebf06 183 TIGRFAM TIGR00059 L17: ribosomal protein bL17 9 117 4.3E-41 T 17-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31315 844ea57bedaac6324787065dcf2ebf06 183 SUPERFAMILY SSF64263 1 117 7.19E-47 T 17-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31315 844ea57bedaac6324787065dcf2ebf06 183 ProSitePatterns PS01167 Ribosomal protein L17 signature. 34 56 - T 17-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31315 844ea57bedaac6324787065dcf2ebf06 183 Pfam PF01196 Ribosomal protein L17 20 116 1.5E-37 T 17-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31315 844ea57bedaac6324787065dcf2ebf06 183 Hamap MF_01368 50S ribosomal protein L17 [rplQ]. 5 116 27.325 T 17-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31315 844ea57bedaac6324787065dcf2ebf06 183 Gene3D G3DSA:3.90.1030.10 3 117 1.0E-46 T 17-03-2017 IPR000456 Ribosomal protein L17 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 TIGRFAM TIGR00666 PBP4: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 312 508 1.3E-48 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 SUPERFAMILY SSF56601 151 530 3.96E-64 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 348 370 1.3E-23 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 420 434 1.3E-23 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 405 419 1.3E-23 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 184 203 1.3E-23 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 485 498 1.3E-23 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 Gene3D G3DSA:3.40.710.10 160 250 2.3E-6 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 146 282 4.2E-23 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 310 525 2.9E-60 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS26470 36e94505cbc32827061db06946f7d935 532 Gene3D G3DSA:3.40.710.10 304 531 2.4E-69 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS24570 aa3a24ec5c50f19767c394b4c4e27369 385 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 177 281 2.7E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24570 aa3a24ec5c50f19767c394b4c4e27369 385 SUPERFAMILY SSF55874 155 282 2.88E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24570 aa3a24ec5c50f19767c394b4c4e27369 385 Gene3D G3DSA:3.30.565.10 173 281 1.8E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 SUPERFAMILY SSF52540 287 499 2.28E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 Gene3D G3DSA:3.40.50.300 288 499 1.2E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 Gene3D G3DSA:3.40.50.300 14 242 2.0E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 ProSitePatterns PS00211 ABC transporters family signature. 414 428 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 SMART SM00382 296 490 0.29 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 SMART SM00382 44 233 1.6E-4 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 Pfam PF00005 ABC transporter 288 441 2.3E-13 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 Pfam PF00005 ABC transporter 36 185 4.1E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01040 dd8a546c67edcd831249d37a340059f9 511 SUPERFAMILY SSF52540 15 242 3.72E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 Gene3D G3DSA:3.40.190.10 92 183 5.6E-16 T 17-03-2017 SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 SUPERFAMILY SSF46785 5 88 1.76E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 65 1.8E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 SUPERFAMILY SSF53850 91 296 6.11E-27 T 17-03-2017 SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 Gene3D G3DSA:3.40.190.10 184 265 5.7E-10 T 17-03-2017 SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 Pfam PF03466 LysR substrate binding domain 90 294 9.0E-30 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 Gene3D G3DSA:1.10.10.10 5 87 3.2E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 21 32 8.6E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 32 42 8.6E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS34965 c4e06a8a7c59f80f17ab46c177b8ef64 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 53 8.6E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 SMART SM00944 58 197 2.9E-39 T 17-03-2017 IPR015366 Peptidase S53, activation domain GO:0008236 Reactome: R-HSA-381038 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 SUPERFAMILY SSF52743 248 600 3.23E-49 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 SUPERFAMILY SSF52743 630 651 3.23E-49 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 547 557 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 Gene3D G3DSA:3.40.50.200 245 652 3.9E-77 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 Pfam PF09286 Pro-kumamolisin, activation domain 63 196 4.7E-26 T 17-03-2017 IPR015366 Peptidase S53, activation domain GO:0008236 Reactome: R-HSA-381038 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 Pfam PF00082 Subtilase family 328 566 1.4E-13 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS21905 daa3bafd3e4e58bac08dd7e9e16d12e6 660 SUPERFAMILY SSF54897 47 216 2.21E-38 T 17-03-2017 IPR009020 Proteinase propeptide inhibitor SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 SUPERFAMILY SSF54364 5 78 8.76E-28 T 17-03-2017 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 Gene3D G3DSA:3.10.20.80 3 78 1.4E-34 T 17-03-2017 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 Gene3D G3DSA:3.30.110.10 79 171 1.8E-38 T 17-03-2017 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 Hamap MF_00080 Translation initiation factor IF-3 [infC]. 1 170 29.534 T 17-03-2017 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 Pfam PF00707 Translation initiation factor IF-3, C-terminal domain 84 167 6.0E-34 T 17-03-2017 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 TIGRFAM TIGR00168 infC: translation initiation factor IF-3 7 170 9.5E-61 T 17-03-2017 IPR001288 Translation initiation factor 3 GO:0003743|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 Pfam PF05198 Translation initiation factor IF-3, N-terminal domain 7 76 1.8E-28 T 17-03-2017 IPR019814 Translation initiation factor 3, N-terminal GO:0003743|GO:0006413 Reactome: R-HSA-5368286 SHXM_RS13145 04103e328bd1b5fad8ccddb6f1d975d5 213 SUPERFAMILY SSF55200 85 169 3.92E-32 T 17-03-2017 IPR019815 Translation initiation factor 3, C-terminal GO:0006413 Reactome: R-HSA-5368286 SHXM_RS32125 4bb79a8018a61b39934dbf6c61657c06 734 Pfam PF01968 Hydantoinase/oxoprolinase 242 540 4.8E-92 T 17-03-2017 IPR002821 Hydantoinase/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS32125 4bb79a8018a61b39934dbf6c61657c06 734 SUPERFAMILY SSF53067 434 527 1.3E-6 T 17-03-2017 SHXM_RS32125 4bb79a8018a61b39934dbf6c61657c06 734 SUPERFAMILY SSF53067 45 118 1.3E-6 T 17-03-2017 SHXM_RS32125 4bb79a8018a61b39934dbf6c61657c06 734 SUPERFAMILY SSF53067 300 388 1.3E-6 T 17-03-2017 SHXM_RS32125 4bb79a8018a61b39934dbf6c61657c06 734 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 44 220 1.0E-46 T 17-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS47590 82e171916aa9860d79566440d64e1f56 326 PRINTS PR00069 Aldo-keto reductase signature 43 67 5.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS47590 82e171916aa9860d79566440d64e1f56 326 PRINTS PR00069 Aldo-keto reductase signature 140 157 5.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS47590 82e171916aa9860d79566440d64e1f56 326 PRINTS PR00069 Aldo-keto reductase signature 109 127 5.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS47590 82e171916aa9860d79566440d64e1f56 326 SUPERFAMILY SSF51430 7 308 1.57E-101 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47590 82e171916aa9860d79566440d64e1f56 326 Pfam PF00248 Aldo/keto reductase family 13 308 6.0E-78 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47590 82e171916aa9860d79566440d64e1f56 326 Gene3D G3DSA:3.20.20.100 3 310 5.0E-110 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS13570 16339c759730f1177f580e9f7f4db3f6 493 Gene3D G3DSA:1.10.1740.10 9 54 9.5E-6 T 17-03-2017 SHXM_RS13570 16339c759730f1177f580e9f7f4db3f6 493 SUPERFAMILY SSF88659 88 146 1.44E-5 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS13570 16339c759730f1177f580e9f7f4db3f6 493 Gene3D G3DSA:1.10.10.10 94 147 6.8E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13570 16339c759730f1177f580e9f7f4db3f6 493 SUPERFAMILY SSF88946 9 55 1.02E-6 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20860 ccec7fb90a51081135d01809a2ec865f 401 Gene3D G3DSA:3.40.190.10 128 293 2.8E-34 T 17-03-2017 SHXM_RS20860 ccec7fb90a51081135d01809a2ec865f 401 Pfam PF01547 Bacterial extracellular solute-binding protein 36 302 5.0E-31 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS20860 ccec7fb90a51081135d01809a2ec865f 401 SUPERFAMILY SSF53850 3 394 3.31E-61 T 17-03-2017 SHXM_RS20860 ccec7fb90a51081135d01809a2ec865f 401 Gene3D G3DSA:3.40.190.10 2 123 3.8E-11 T 17-03-2017 SHXM_RS20860 ccec7fb90a51081135d01809a2ec865f 401 Gene3D G3DSA:3.40.190.10 294 330 3.8E-11 T 17-03-2017 SHXM_RS47180 614037348041e86af4f387061f3767d5 311 Gene3D G3DSA:1.20.1250.20 68 267 1.9E-20 T 17-03-2017 SHXM_RS47180 614037348041e86af4f387061f3767d5 311 SUPERFAMILY SSF103473 12 267 4.71E-24 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47180 614037348041e86af4f387061f3767d5 311 Pfam PF07690 Major Facilitator Superfamily 57 218 2.1E-12 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 35 49 1.6E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 65 1.6E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 Gene3D G3DSA:1.10.10.10 10 79 1.6E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 SMART SM00345 16 75 7.0E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 74 9.8E-21 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 Gene3D G3DSA:1.20.120.530 94 225 1.5E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 SUPERFAMILY SSF48008 96 225 1.31E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 Pfam PF07729 FCD domain 98 220 3.1E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 SMART SM00895 98 221 8.3E-24 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS38550 773898bf2573cd56b7622618bf96dfdb 235 SUPERFAMILY SSF46785 8 79 2.2E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32650 07ed0a5c9cacbfde54740896cb047a7e 547 Pfam PF00905 Penicillin binding protein transpeptidase domain 271 543 3.3E-36 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS32650 07ed0a5c9cacbfde54740896cb047a7e 547 SUPERFAMILY SSF56601 246 544 4.4E-54 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32650 07ed0a5c9cacbfde54740896cb047a7e 547 Pfam PF05223 NTF2-like N-terminal transpeptidase domain 62 169 3.2E-5 T 17-03-2017 IPR007887 NTF2-like N-terminal transpeptidase GO:0046677 SHXM_RS32650 07ed0a5c9cacbfde54740896cb047a7e 547 Gene3D G3DSA:3.40.710.10 251 544 1.6E-54 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 PIRSF PIRSF036990 6 221 2.5E-66 T 17-03-2017 IPR017080 Uncharacterised conserved protein UCP036990, CBS, BON SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 Pfam PF00571 CBS domain 8 59 1.7E-10 T 17-03-2017 IPR000644 CBS domain SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 Pfam PF00571 CBS domain 91 143 1.3E-17 T 17-03-2017 IPR000644 CBS domain SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 Pfam PF04972 BON domain 147 214 7.8E-13 T 17-03-2017 IPR007055 BON domain SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 Gene3D G3DSA:3.20.20.70 8 180 3.0E-33 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 SMART SM00116 15 63 0.037 T 17-03-2017 IPR000644 CBS domain SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 SMART SM00116 96 144 1.1E-12 T 17-03-2017 IPR000644 CBS domain SHXM_RS08020 b9b1ca8d2bb598b3a3448a05f31d3704 221 SUPERFAMILY SSF54631 6 147 2.91E-34 T 17-03-2017 SHXM_RS24345 0ea362f3a23874d487e53ccd06c74df6 358 SUPERFAMILY SSF49319 41 134 3.66E-6 T 17-03-2017 IPR027273 Neocarzinostatin-like SHXM_RS24345 0ea362f3a23874d487e53ccd06c74df6 358 Gene3D G3DSA:2.60.40.230 41 110 8.2E-4 T 17-03-2017 IPR027273 Neocarzinostatin-like SHXM_RS40880 0bf0fc423e01166715d50f072d842fea 258 Gene3D G3DSA:3.40.1010.10 5 149 1.4E-36 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS40880 0bf0fc423e01166715d50f072d842fea 258 PIRSF PIRSF036525 5 258 8.2E-103 T 17-03-2017 IPR012797 Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase GO:0009236|GO:0043819 KEGG: 00860+2.1.1.152|MetaCyc: PWY-7376 SHXM_RS40880 0bf0fc423e01166715d50f072d842fea 258 Gene3D G3DSA:3.30.950.10 150 255 5.6E-46 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS40880 0bf0fc423e01166715d50f072d842fea 258 SUPERFAMILY SSF53790 3 255 1.19E-33 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS40880 0bf0fc423e01166715d50f072d842fea 258 TIGRFAM TIGR02434 CobF: precorrin-6A synthase (deacetylating) 6 255 2.3E-102 T 17-03-2017 IPR012797 Cobalamin (vitamin B12) biosynthesis CobF, precorrin-6A synthase GO:0009236|GO:0043819 KEGG: 00860+2.1.1.152|MetaCyc: PWY-7376 SHXM_RS40880 0bf0fc423e01166715d50f072d842fea 258 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 7 230 4.8E-31 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS01580 f1f019bdf9c849d5863429098651efc1 293 Pfam PF00561 alpha/beta hydrolase fold 38 185 2.4E-15 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01580 f1f019bdf9c849d5863429098651efc1 293 SUPERFAMILY SSF53474 16 291 1.59E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01580 f1f019bdf9c849d5863429098651efc1 293 Gene3D G3DSA:3.40.50.1820 10 291 6.3E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 Gene3D G3DSA:3.50.50.60 175 258 6.9E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 Gene3D G3DSA:3.50.50.60 343 392 6.9E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 Gene3D G3DSA:3.50.50.60 37 127 6.9E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 PRINTS PR00162 Rieske 2Fe-2S subunit signature 484 496 2.2E-8 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 PRINTS PR00162 Rieske 2Fe-2S subunit signature 496 508 2.2E-8 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 PRINTS PR00162 Rieske 2Fe-2S subunit signature 463 474 2.2E-8 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 SUPERFAMILY SSF51905 38 259 1.42E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 SUPERFAMILY SSF51905 343 404 1.42E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 Pfam PF01266 FAD dependent oxidoreductase 39 381 2.3E-45 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 Pfam PF00355 Rieske [2Fe-2S] domain 432 509 1.4E-15 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 SUPERFAMILY SSF50022 390 510 9.3E-26 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS39285 fa0f6e63ad18e537c22863965be33078 529 Gene3D G3DSA:2.102.10.10 433 509 7.5E-27 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS46285 1ad3c6580d8a4871009338e2f53f30ca 201 Gene3D G3DSA:1.10.357.10 13 197 1.6E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS46285 1ad3c6580d8a4871009338e2f53f30ca 201 SUPERFAMILY SSF48498 89 198 1.2E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS46285 1ad3c6580d8a4871009338e2f53f30ca 201 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 66 1.1E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS46285 1ad3c6580d8a4871009338e2f53f30ca 201 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 21 34 5.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS46285 1ad3c6580d8a4871009338e2f53f30ca 201 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 5.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS46285 1ad3c6580d8a4871009338e2f53f30ca 201 SUPERFAMILY SSF46689 12 91 1.13E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS43110 2762cd7c6a1686d76fadfb058f1c232d 359 Gene3D G3DSA:3.40.640.10 14 265 1.7E-60 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS43110 2762cd7c6a1686d76fadfb058f1c232d 359 Pfam PF01212 Beta-eliminating lyase 22 308 1.2E-57 T 17-03-2017 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 Reactome: R-HSA-6783984 SHXM_RS43110 2762cd7c6a1686d76fadfb058f1c232d 359 Gene3D G3DSA:3.90.1150.10 269 355 1.0E-27 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS43110 2762cd7c6a1686d76fadfb058f1c232d 359 SUPERFAMILY SSF53383 21 355 5.77E-94 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS43545 8b931b38e2bdf783999d964689fed403 136 Gene3D G3DSA:3.10.180.10 4 134 6.6E-29 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS43545 8b931b38e2bdf783999d964689fed403 136 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 132 9.3E-15 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS43545 8b931b38e2bdf783999d964689fed403 136 SUPERFAMILY SSF54593 5 133 1.48E-26 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 SUPERFAMILY SSF74650 622 999 1.19E-59 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 256 508 8.1E-82 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 SUPERFAMILY SSF88688 519 621 1.01E-24 T 17-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 SUPERFAMILY SSF88713 251 518 1.25E-72 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 Pfam PF09261 Alpha mannosidase middle domain 520 597 1.3E-25 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 Gene3D G3DSA:3.20.110.10 205 521 7.2E-82 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 SMART SM00872 520 598 5.9E-37 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 659 997 2.4E-55 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS01505 cee574d5749e7edab6e9da6286cca6e8 1001 Gene3D G3DSA:1.20.1270.50 522 620 7.2E-21 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 SUPERFAMILY SSF52821 4 147 3.54E-35 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 SMART SM00450 6 130 1.3E-23 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 SMART SM00450 151 269 6.2E-17 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 ProSitePatterns PS00380 Rhodanese signature 1. 38 49 - T 17-03-2017 IPR001307 Thiosulphate sulfurtransferase, conserved site GO:0004792 KEGG: 00920+2.8.1.1|MetaCyc: PWY-5350 SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 Gene3D G3DSA:3.40.250.10 151 276 2.5E-38 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 Gene3D G3DSA:3.40.250.10 2 147 1.1E-44 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 Pfam PF00581 Rhodanese-like domain 159 265 8.4E-11 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 Pfam PF00581 Rhodanese-like domain 9 126 1.5E-17 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37565 4bfe98c16d52fcd509b777c974c3b712 278 SUPERFAMILY SSF52821 149 276 1.18E-32 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Gene3D G3DSA:3.30.230.10 496 608 3.1E-48 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Pfam PF14492 Elongation Factor G, domain II 416 490 1.1E-34 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SUPERFAMILY SSF54980 615 702 1.01E-30 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Pfam PF00679 Elongation factor G C-terminus 613 698 1.8E-30 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 TIGRFAM TIGR00484 EF-G: translation elongation factor G 5 704 0.0 T 17-03-2017 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SUPERFAMILY SSF52540 7 293 1.29E-103 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SUPERFAMILY SSF50447 276 416 5.65E-36 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SMART SM00889 492 610 7.0E-73 T 17-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SUPERFAMILY SSF54980 416 493 2.48E-25 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Gene3D G3DSA:2.40.30.10 317 416 4.2E-38 T 17-03-2017 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Gene3D G3DSA:3.30.70.240 609 703 2.2E-34 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Pfam PF03764 Elongation factor G, domain IV 491 610 2.3E-48 T 17-03-2017 IPR005517 Translation elongation factor EFG/EF2, domain IV GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 52 67 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SMART SM00838 612 699 2.3E-58 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Gene3D G3DSA:3.30.70.870 417 492 6.9E-39 T 17-03-2017 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 PRINTS PR00315 GTP-binding elongation factor signature 99 110 4.1E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 PRINTS PR00315 GTP-binding elongation factor signature 135 144 4.1E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 PRINTS PR00315 GTP-binding elongation factor signature 13 26 4.1E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 PRINTS PR00315 GTP-binding elongation factor signature 59 67 4.1E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 PRINTS PR00315 GTP-binding elongation factor signature 83 93 4.1E-16 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 11 184 3.1E-33 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Pfam PF03144 Elongation factor Tu domain 2 336 402 5.2E-14 T 17-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Hamap MF_00054_B Elongation factor G [fusA]. 7 703 110.13 T 17-03-2017 IPR004540 Translation elongation factor EFG/EF2 GO:0003746|GO:0005525|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Pfam PF00009 Elongation factor Tu GTP binding domain 10 293 7.0E-66 T 17-03-2017 SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 SUPERFAMILY SSF54211 491 611 1.49E-41 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS31135 e77b820e1564d95e57a6ad0c5ef33d37 706 Gene3D G3DSA:3.40.50.300 7 298 2.0E-104 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17990 b556d318ca65c6d08a84148e52345500 334 TIGRFAM TIGR03718 R_switched_Alx: integral membrane protein, TerC family 4 312 2.0E-117 T 17-03-2017 IPR022369 Integral membrane protein TerC, riboswitch-linked GO:0016021 SHXM_RS17990 b556d318ca65c6d08a84148e52345500 334 Pfam PF03741 Integral membrane protein TerC family 69 275 8.0E-54 T 17-03-2017 IPR005496 Integral membrane protein TerC GO:0016021 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 SUPERFAMILY SSF46785 38 109 1.91E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 SUPERFAMILY SSF53383 126 487 1.2E-75 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 SMART SM00345 46 105 1.0E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 65 79 1.8E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 79 95 1.8E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 Pfam PF00392 Bacterial regulatory proteins, gntR family 43 102 9.4E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 Gene3D G3DSA:3.40.640.10 142 356 3.1E-44 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 Gene3D G3DSA:3.90.1150.10 357 487 7.0E-19 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 Gene3D G3DSA:1.10.10.10 38 104 2.7E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11510 d48834dab427459e97bcb3ebc1afb53e 507 Pfam PF00155 Aminotransferase class I and II 166 470 8.3E-30 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 Pfam PF01761 3-dehydroquinate synthase 74 330 1.4E-93 T 17-03-2017 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 SUPERFAMILY SSF56796 20 361 2.88E-99 T 17-03-2017 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 PIRSF PIRSF001455 20 364 8.7E-100 T 17-03-2017 IPR030963 3-dehydroquinate synthase family GO:0009073|GO:0016838 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 TIGRFAM TIGR01357 aroB: 3-dehydroquinate synthase 23 349 6.4E-106 T 17-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 Gene3D G3DSA:3.40.50.1970 19 178 2.0E-54 T 17-03-2017 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 12 363 36.566 T 17-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS12410 ad93fcfe75bb003a32d1ec6c1f15e21d 366 Gene3D G3DSA:1.20.1090.10 180 361 4.1E-59 T 17-03-2017 SHXM_RS23690 d292632820d8bae055ed1b19882ac5e0 447 Gene3D G3DSA:3.65.10.10 229 439 1.6E-46 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS23690 d292632820d8bae055ed1b19882ac5e0 447 SUPERFAMILY SSF55205 6 440 2.49E-111 T 17-03-2017 IPR013792 RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta GO:0003824 SHXM_RS23690 d292632820d8bae055ed1b19882ac5e0 447 Gene3D G3DSA:3.65.10.10 25 228 9.0E-53 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS23690 d292632820d8bae055ed1b19882ac5e0 447 TIGRFAM TIGR01072 murA: UDP-N-acetylglucosamine 1-carboxyvinyltransferase 7 439 5.8E-130 T 17-03-2017 IPR005750 UDP-N-acetylglucosamine 1-carboxyvinyltransferase GO:0008760|GO:0019277 KEGG: 00520+2.5.1.7|KEGG: 00550+2.5.1.7|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS23690 d292632820d8bae055ed1b19882ac5e0 447 Pfam PF00275 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) 11 431 5.7E-58 T 17-03-2017 IPR001986 Enolpyruvate transferase domain GO:0016765 SHXM_RS04140 4f4f9e7b9f009660ff822ac61a73a769 340 Gene3D G3DSA:3.20.20.140 5 106 4.1E-4 T 17-03-2017 SHXM_RS04140 4f4f9e7b9f009660ff822ac61a73a769 340 SUPERFAMILY SSF51445 83 313 3.92E-21 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04140 4f4f9e7b9f009660ff822ac61a73a769 340 Gene3D G3DSA:3.20.20.80 107 317 5.5E-7 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS12020 27e2637f44029f7142d2790c306fb5ed 385 Gene3D G3DSA:3.30.360.10 167 380 1.1E-19 T 17-03-2017 SHXM_RS12020 27e2637f44029f7142d2790c306fb5ed 385 Gene3D G3DSA:3.40.50.720 38 153 9.6E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12020 27e2637f44029f7142d2790c306fb5ed 385 SUPERFAMILY SSF55347 167 308 4.91E-12 T 17-03-2017 SHXM_RS12020 27e2637f44029f7142d2790c306fb5ed 385 SUPERFAMILY SSF51735 39 154 6.47E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12020 27e2637f44029f7142d2790c306fb5ed 385 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 40 146 5.4E-15 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 Gene3D G3DSA:3.90.110.10 169 426 1.2E-74 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 SUPERFAMILY SSF51735 4 167 1.82E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 Gene3D G3DSA:3.40.50.720 2 167 4.3E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 SUPERFAMILY SSF56327 170 426 6.19E-66 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 111 131 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 192 204 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 140 157 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 166 177 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 74 90 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 95 108 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 PRINTS PR00732 Glycosyl hydrolase family 4 signature 5 20 4.6E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 Pfam PF02056 Family 4 glycosyl hydrolase 5 186 1.2E-55 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS10950 8dd0ee4d51e888558b46555f924d7893 436 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 196 402 3.5E-60 T 17-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 Pfam PF00082 Subtilase family 158 386 1.4E-42 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 Pfam PF05922 Peptidase inhibitor I9 78 124 3.9E-6 T 17-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 163 174 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 SUPERFAMILY SSF54897 55 124 1.47E-9 T 17-03-2017 IPR009020 Proteinase propeptide inhibitor SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 PRINTS PR00723 Subtilisin serine protease family (S8) signature 349 365 3.0E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 PRINTS PR00723 Subtilisin serine protease family (S8) signature 158 177 3.0E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 PRINTS PR00723 Subtilisin serine protease family (S8) signature 196 209 3.0E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 SUPERFAMILY SSF52743 132 387 5.63E-76 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 200 210 - T 17-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 Gene3D G3DSA:3.30.70.80 48 129 3.2E-15 T 17-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 350 360 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS38635 f7ac988c17b7b6901329d9a8b992f42b 406 Gene3D G3DSA:3.40.50.200 134 401 1.3E-86 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 Gene3D G3DSA:3.40.50.980 194 344 1.7E-22 T 17-03-2017 SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 Gene3D G3DSA:2.30.38.10 352 434 3.8E-15 T 17-03-2017 SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 Gene3D G3DSA:3.40.50.980 33 193 3.6E-26 T 17-03-2017 SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 SUPERFAMILY SSF56801 28 538 6.28E-132 T 17-03-2017 SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 Pfam PF13193 AMP-binding enzyme C-terminal domain 450 528 9.5E-24 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 Gene3D G3DSA:3.30.300.30 436 536 2.6E-31 T 17-03-2017 SHXM_RS06365 9ef00dd89c263f927990120adf50ab49 544 Pfam PF00501 AMP-binding enzyme 28 440 9.0E-69 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS02045 334b5a8b932031eb1c4c0cdd2a35c4bb 330 SUPERFAMILY SSF161098 113 313 4.19E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02045 334b5a8b932031eb1c4c0cdd2a35c4bb 330 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 136 327 1.3E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02045 334b5a8b932031eb1c4c0cdd2a35c4bb 330 Gene3D G3DSA:1.10.3720.10 114 322 1.6E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50200 3589ae7b61ab038a921e3500a3c6379a 414 Gene3D G3DSA:3.40.190.10 156 348 4.7E-39 T 17-03-2017 SHXM_RS50200 3589ae7b61ab038a921e3500a3c6379a 414 SUPERFAMILY SSF53850 43 406 2.02E-69 T 17-03-2017 SHXM_RS50200 3589ae7b61ab038a921e3500a3c6379a 414 Pfam PF13416 Bacterial extracellular solute-binding protein 60 356 1.2E-35 T 17-03-2017 SHXM_RS50200 3589ae7b61ab038a921e3500a3c6379a 414 Gene3D G3DSA:3.40.190.10 43 155 1.1E-5 T 17-03-2017 SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 Gene3D G3DSA:3.40.50.720 181 262 3.3E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 Gene3D G3DSA:3.40.50.720 297 338 3.3E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 Pfam PF13823 Alcohol dehydrogenase GroES-associated 1 22 5.4E-13 T 17-03-2017 IPR027399 Alcohol dehydrogenase GroES-associated SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 Pfam PF00107 Zinc-binding dehydrogenase 189 262 5.6E-9 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 SUPERFAMILY SSF50129 1 174 1.18E-57 T 17-03-2017 IPR011032 GroES-like SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 Gene3D G3DSA:3.90.180.10 1 180 6.9E-49 T 17-03-2017 IPR011032 GroES-like SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 SUPERFAMILY SSF51735 156 356 1.73E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45135 b18873cf2661d1d230e42caa6b5423dc 397 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 142 5.9E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS15350 cbcd359eb26910bfbfb46039dccdffc6 176 SUPERFAMILY SSF53098 13 143 2.43E-14 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15350 cbcd359eb26910bfbfb46039dccdffc6 176 Pfam PF13683 Integrase core domain 76 141 3.9E-10 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15350 cbcd359eb26910bfbfb46039dccdffc6 176 Gene3D G3DSA:3.30.420.10 14 143 1.3E-12 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS46155 a1d62fb02f29bf7afa0a1d66e98092b8 335 SUPERFAMILY SSF51430 13 327 1.7E-91 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS46155 a1d62fb02f29bf7afa0a1d66e98092b8 335 Pfam PF00248 Aldo/keto reductase family 28 327 5.3E-67 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS46155 a1d62fb02f29bf7afa0a1d66e98092b8 335 Gene3D G3DSA:3.20.20.100 13 327 1.1E-86 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS08470 980b3bfbe2f59117dda4df685d0b6703 103 Gene3D G3DSA:2.10.150.10 2 102 6.9E-45 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08470 980b3bfbe2f59117dda4df685d0b6703 103 TIGRFAM TIGR00192 urease_beta: urease, beta subunit 1 102 9.4E-36 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08470 980b3bfbe2f59117dda4df685d0b6703 103 Hamap MF_01954 Urease subunit beta [ureB]. 1 101 29.287 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08470 980b3bfbe2f59117dda4df685d0b6703 103 Pfam PF00699 Urease beta subunit 3 99 1.5E-39 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS08470 980b3bfbe2f59117dda4df685d0b6703 103 SUPERFAMILY SSF51278 1 102 3.4E-43 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS13085 2956a600cc1aceae9ad5c4368e662f4e 270 PRINTS PR01837 MgtC/SapB protein signature 34 53 9.0E-41 T 17-03-2017 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SHXM_RS13085 2956a600cc1aceae9ad5c4368e662f4e 270 PRINTS PR01837 MgtC/SapB protein signature 53 71 9.0E-41 T 17-03-2017 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SHXM_RS13085 2956a600cc1aceae9ad5c4368e662f4e 270 PRINTS PR01837 MgtC/SapB protein signature 114 138 9.0E-41 T 17-03-2017 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SHXM_RS13085 2956a600cc1aceae9ad5c4368e662f4e 270 PRINTS PR01837 MgtC/SapB protein signature 87 109 9.0E-41 T 17-03-2017 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SHXM_RS13085 2956a600cc1aceae9ad5c4368e662f4e 270 Pfam PF02308 MgtC family 31 154 4.3E-35 T 17-03-2017 IPR003416 MgtC/SapB/SrpB/YhiD family GO:0016020 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 Gene3D G3DSA:3.40.1410.10 77 250 4.5E-40 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 SMART SM00866 106 246 2.9E-25 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 40 54 3.2E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 54 70 3.2E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 SUPERFAMILY SSF46785 17 84 7.71E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 Pfam PF00392 Bacterial regulatory proteins, gntR family 19 80 1.3E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 Pfam PF07702 UTRA domain 107 240 2.3E-29 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 SMART SM00345 23 80 1.6E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 Gene3D G3DSA:1.10.10.10 18 76 1.0E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00850 a91239cd81e2ec1b61032a631f0a5862 256 SUPERFAMILY SSF64288 68 250 1.24E-37 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS20640 e1b821b8da2503900a4d63751846d80e 231 Pfam PF02698 DUF218 domain 58 174 1.3E-24 T 17-03-2017 IPR003848 Domain of unknown function DUF218 SHXM_RS20640 e1b821b8da2503900a4d63751846d80e 231 Gene3D G3DSA:3.40.50.620 49 174 1.2E-12 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 TIGRFAM TIGR02013 rpoB: DNA-directed RNA polymerase, beta subunit 236 842 0.0 T 17-03-2017 IPR010243 DNA-directed RNA polymerase beta subunit, bacterial-type GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 SUPERFAMILY SSF64484 22 1132 0.0 T 17-03-2017 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Pfam PF00562 RNA polymerase Rpb2, domain 6 630 1046 2.7E-155 T 17-03-2017 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Pfam PF04560 RNA polymerase Rpb2, domain 7 1048 1122 4.0E-27 T 17-03-2017 IPR007641 RNA polymerase Rpb2, domain 7 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Pfam PF10385 RNA polymerase beta subunit external 1 domain 502 568 3.1E-25 T 17-03-2017 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:2.40.50.150 734 864 4.3E-56 T 17-03-2017 IPR014724 RNA polymerase Rpb2, OB-fold GO:0003899 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:2.30.150.10 503 568 1.0E-27 T 17-03-2017 IPR019462 DNA-directed RNA polymerase, beta subunit, external 1 domain GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:2.40.270.10 698 725 5.2E-76 T 17-03-2017 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:2.40.270.10 865 1024 5.2E-76 T 17-03-2017 IPR007120 DNA-directed RNA polymerase, subunit 2, domain 6 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Hamap MF_01321 DNA-directed RNA polymerase subunit beta [rpoB]. 23 1124 12.31 T 17-03-2017 IPR010243 DNA-directed RNA polymerase beta subunit, bacterial-type GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:3.90.1100.10 30 169 1.0E-145 T 17-03-2017 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:3.90.1100.10 571 625 1.0E-145 T 17-03-2017 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:3.90.1100.10 354 502 1.0E-145 T 17-03-2017 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Pfam PF04563 RNA polymerase beta subunit 66 409 8.3E-21 T 17-03-2017 IPR007644 RNA polymerase, beta subunit, protrusion GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 ProSitePatterns PS01166 RNA polymerases beta chain signature. 868 880 - T 17-03-2017 IPR007121 RNA polymerase, beta subunit, conserved site GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:2.40.50.100 627 697 9.3E-26 T 17-03-2017 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Pfam PF04565 RNA polymerase Rpb2, domain 3 424 492 2.8E-29 T 17-03-2017 IPR007645 RNA polymerase Rpb2, domain 3 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Gene3D G3DSA:3.90.1110.10 171 340 4.7E-68 T 17-03-2017 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS31115 af04ebeddf6175212e1e6bc864f56a3c 1160 Pfam PF04561 RNA polymerase Rpb2, domain 2 169 365 7.3E-29 T 17-03-2017 IPR007642 RNA polymerase Rpb2, domain 2 GO:0003677|GO:0003899|GO:0006351 KEGG: 00230+2.7.7.6|KEGG: 00240+2.7.7.6 SHXM_RS49525 d1e0a84f0d398d3097cfbd1cbb208535 285 SMART SM00382 49 245 1.8E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49525 d1e0a84f0d398d3097cfbd1cbb208535 285 Gene3D G3DSA:3.40.50.300 19 258 2.4E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49525 d1e0a84f0d398d3097cfbd1cbb208535 285 ProSitePatterns PS00211 ABC transporters family signature. 168 182 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS49525 d1e0a84f0d398d3097cfbd1cbb208535 285 SUPERFAMILY SSF52540 20 255 1.69E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49525 d1e0a84f0d398d3097cfbd1cbb208535 285 Pfam PF00005 ABC transporter 40 196 5.7E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 Gene3D G3DSA:2.30.40.10 9 67 2.1E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 Gene3D G3DSA:2.30.40.10 410 491 1.6E-12 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 SUPERFAMILY SSF51338 9 62 9.92E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 SUPERFAMILY SSF51338 432 482 9.92E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 SUPERFAMILY SSF51556 62 282 4.09E-32 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 SUPERFAMILY SSF51556 318 421 4.09E-32 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 Gene3D G3DSA:3.20.20.140 68 274 2.2E-42 T 17-03-2017 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 Gene3D G3DSA:3.20.20.140 335 409 2.2E-42 T 17-03-2017 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 Pfam PF07969 Amidohydrolase family 166 476 6.1E-14 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS00015 12fdd436674bb277137e01776109eb1d 498 Pfam PF07969 Amidohydrolase family 51 121 1.5E-7 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 SUPERFAMILY SSF46785 43 133 7.14E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 Pfam PF00392 Bacterial regulatory proteins, gntR family 51 109 3.2E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 SMART SM00895 118 242 6.9E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 Pfam PF07729 FCD domain 118 241 2.2E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 Gene3D G3DSA:1.20.120.530 112 252 1.2E-20 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 SMART SM00345 51 109 5.8E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 Gene3D G3DSA:1.10.10.10 38 109 1.0E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15325 8f13e8dee27e83f8aa367967200d199f 254 SUPERFAMILY SSF48008 116 250 2.3E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 SUPERFAMILY SSF48498 96 206 6.85E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 Gene3D G3DSA:1.10.10.60 26 72 2.1E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 SUPERFAMILY SSF46689 26 85 6.98E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 Gene3D G3DSA:1.10.357.10 74 206 8.8E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 36 78 2.5E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 48 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 56 79 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04625 eaf52b5440cf1c4ac34c8f21d207ac1e 216 Pfam PF16859 Bacterial transcriptional repressor C-terminal 93 203 9.7E-29 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS31335 fffc97c1b76602390ce95ae58f9c3244 127 Gene3D G3DSA:3.30.565.10 6 122 1.1E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS31335 fffc97c1b76602390ce95ae58f9c3244 127 SMART SM00387 26 127 8.5E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS31335 fffc97c1b76602390ce95ae58f9c3244 127 SUPERFAMILY SSF55874 23 122 2.13E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS31335 fffc97c1b76602390ce95ae58f9c3244 127 Pfam PF13581 Histidine kinase-like ATPase domain 5 121 9.9E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 SUPERFAMILY SSF46689 211 259 2.91E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 Pfam PF12833 Helix-turn-helix domain 181 258 6.4E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 SUPERFAMILY SSF46689 161 209 1.84E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 Gene3D G3DSA:1.10.10.60 157 212 4.1E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 Gene3D G3DSA:2.60.120.280 7 88 2.6E-11 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 SMART SM00342 175 257 3.3E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 Gene3D G3DSA:1.10.10.60 213 260 8.7E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 SUPERFAMILY SSF51215 7 120 3.01E-19 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS19885 d88ce38c51003f0950c622bd9e6270d4 271 Pfam PF02311 AraC-like ligand binding domain 3 131 5.4E-19 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS02545 82bad14706dedfb2037a328912228478 228 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 172 191 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS02545 82bad14706dedfb2037a328912228478 228 Gene3D G3DSA:2.40.110.10 2 53 2.3E-7 T 17-03-2017 SHXM_RS02545 82bad14706dedfb2037a328912228478 228 Gene3D G3DSA:1.20.140.10 54 215 7.0E-53 T 17-03-2017 SHXM_RS02545 82bad14706dedfb2037a328912228478 228 SUPERFAMILY SSF56645 2 67 6.81E-10 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS02545 82bad14706dedfb2037a328912228478 228 SUPERFAMILY SSF47203 61 218 6.44E-48 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS02545 82bad14706dedfb2037a328912228478 228 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 62 212 2.7E-44 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31900 eef6c2d4b24d437ebec079d1ce9f528e 523 Pfam PF00474 Sodium:solute symporter family 33 416 4.8E-27 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS48215 9c9703bb01967fcf64f7fe720195a645 191 Gene3D G3DSA:1.10.10.10 30 71 7.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48215 9c9703bb01967fcf64f7fe720195a645 191 SUPERFAMILY SSF46689 26 155 2.2E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48215 9c9703bb01967fcf64f7fe720195a645 191 Pfam PF13565 Homeodomain-like domain 59 151 9.6E-16 T 17-03-2017 SHXM_RS49100 9c9703bb01967fcf64f7fe720195a645 191 Gene3D G3DSA:1.10.10.10 30 71 7.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49100 9c9703bb01967fcf64f7fe720195a645 191 SUPERFAMILY SSF46689 26 155 2.2E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49100 9c9703bb01967fcf64f7fe720195a645 191 Pfam PF13565 Homeodomain-like domain 59 151 9.6E-16 T 17-03-2017 SHXM_RS00395 9c9703bb01967fcf64f7fe720195a645 191 Gene3D G3DSA:1.10.10.10 30 71 7.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00395 9c9703bb01967fcf64f7fe720195a645 191 SUPERFAMILY SSF46689 26 155 2.2E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00395 9c9703bb01967fcf64f7fe720195a645 191 Pfam PF13565 Homeodomain-like domain 59 151 9.6E-16 T 17-03-2017 SHXM_RS50160 9c9703bb01967fcf64f7fe720195a645 191 Gene3D G3DSA:1.10.10.10 30 71 7.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50160 9c9703bb01967fcf64f7fe720195a645 191 SUPERFAMILY SSF46689 26 155 2.2E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50160 9c9703bb01967fcf64f7fe720195a645 191 Pfam PF13565 Homeodomain-like domain 59 151 9.6E-16 T 17-03-2017 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Pfam PF13581 Histidine kinase-like ATPase domain 697 800 1.1E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Gene3D G3DSA:3.30.450.40 258 440 3.4E-33 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SUPERFAMILY SSF81606 476 682 4.97E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Pfam PF01590 GAF domain 373 431 2.2E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SMART SM00091 10 77 0.18 T 17-03-2017 IPR000014 PAS domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SMART SM00091 131 197 0.0013 T 17-03-2017 IPR000014 PAS domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SUPERFAMILY SSF55874 722 799 6.02E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Pfam PF08448 PAS fold 137 248 5.7E-21 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Pfam PF00989 PAS fold 19 120 9.3E-11 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Gene3D G3DSA:3.30.450.20 17 120 3.9E-12 T 17-03-2017 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Gene3D G3DSA:3.30.450.20 131 248 3.2E-18 T 17-03-2017 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SUPERFAMILY SSF55781 287 436 2.62E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SUPERFAMILY SSF55785 16 115 3.74E-13 T 17-03-2017 IPR000014 PAS domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SMART SM00331 463 683 3.8E-32 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 17 120 3.7E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 132 255 4.3E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 490 683 3.2E-49 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06120 88a264b2cccfafa8de4acef5e48fccfa 813 SUPERFAMILY SSF55785 129 246 1.12E-14 T 17-03-2017 IPR000014 PAS domain SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 PIRSF PIRSF006468 5 361 2.1E-130 T 17-03-2017 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|Reactome: R-HSA-70895 SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 TIGRFAM TIGR01123 ilvE_II: branched-chain amino acid aminotransferase 48 358 1.0E-131 T 17-03-2017 IPR005786 Branched-chain amino acid aminotransferase II GO:0004084|GO:0009081 KEGG: 00270+2.6.1.42|KEGG: 00280+2.6.1.42|KEGG: 00290+2.6.1.42|KEGG: 00770+2.6.1.42|KEGG: 00966+2.6.1.42|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5108|Reactome: R-HSA-70895 SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 Gene3D G3DSA:3.30.470.10 21 178 2.2E-72 T 17-03-2017 SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 ProSitePatterns PS00770 Aminotransferases class-IV signature. 237 266 - T 17-03-2017 IPR018300 Aminotransferase, class IV, conserved site GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 Pfam PF01063 Amino-transferase class IV 74 317 8.8E-34 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 SUPERFAMILY SSF56752 12 358 5.23E-119 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS36240 5c251f0c5ec4e1a3beabb5e631592321 361 Gene3D G3DSA:3.20.10.10 179 346 1.2E-65 T 17-03-2017 SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 Gene3D G3DSA:1.10.357.10 59 196 2.4E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 SUPERFAMILY SSF48498 85 196 2.75E-19 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 Gene3D G3DSA:1.10.10.60 13 58 2.6E-24 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 62 3.2E-23 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 SUPERFAMILY SSF46689 5 87 1.45E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 ProSitePatterns PS01081 TetR-type HTH domain signature. 28 59 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 6.0E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16370 1de506d3adc0a9043c8f541dfde2fd54 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 6.0E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 Gene3D G3DSA:3.40.50.2300 5 158 2.9E-24 T 17-03-2017 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 SMART SM00448 6 130 2.2E-9 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 SMART SM00421 158 220 7.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 Pfam PF00072 Response regulator receiver domain 8 118 7.3E-14 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 161 175 2.2E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 191 203 2.2E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 175 191 2.2E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 Pfam PF00196 Bacterial regulatory proteins, luxR family 161 205 3.6E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 Gene3D G3DSA:1.10.10.10 159 223 3.5E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30910 f9e78736e7b336f69f2d9a42db02b1bd 224 SUPERFAMILY SSF52172 4 179 4.77E-15 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 139 229 1.4E-24 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 Gene3D G3DSA:2.40.110.10 138 229 5.5E-38 T 17-03-2017 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 Gene3D G3DSA:1.10.540.10 8 137 2.9E-35 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 242 388 3.3E-28 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 Gene3D G3DSA:1.20.140.10 230 390 7.9E-40 T 17-03-2017 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 23 135 1.2E-27 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 SUPERFAMILY SSF47203 242 390 9.83E-39 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS16945 eb1ae58c39a2142353b537497f61af53 395 SUPERFAMILY SSF56645 9 240 4.45E-75 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 SUPERFAMILY SSF52821 155 279 6.29E-32 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 ProSitePatterns PS00380 Rhodanese signature 1. 41 52 - T 17-03-2017 IPR001307 Thiosulphate sulfurtransferase, conserved site GO:0004792 KEGG: 00920+2.8.1.1|MetaCyc: PWY-5350 SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 Gene3D G3DSA:3.40.250.10 156 279 4.0E-37 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 Gene3D G3DSA:3.40.250.10 2 144 3.5E-47 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 Pfam PF00581 Rhodanese-like domain 168 270 5.6E-11 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 Pfam PF00581 Rhodanese-like domain 10 130 1.2E-18 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 SMART SM00450 156 274 6.2E-15 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 SMART SM00450 7 134 1.1E-27 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS10905 eb4e03bd0b4536f464cf9eb5ae180b4b 283 SUPERFAMILY SSF52821 3 143 2.36E-39 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS25110 f4265b252f5680df81d53fb1e4613b6a 156 Pfam PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit 39 139 1.4E-16 T 17-03-2017 IPR000701 Succinate dehydrogenase/Fumarate reductase, transmembrane subunit GO:0016627 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25110 f4265b252f5680df81d53fb1e4613b6a 156 SUPERFAMILY SSF81343 31 153 1.92E-31 T 17-03-2017 SHXM_RS25110 f4265b252f5680df81d53fb1e4613b6a 156 Gene3D G3DSA:1.20.950.10 30 155 4.1E-38 T 17-03-2017 SHXM_RS49790 ddba02984b68581ca106b7e32205c718 487 SUPERFAMILY SSF48264 49 460 4.58E-26 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS49790 ddba02984b68581ca106b7e32205c718 487 Gene3D G3DSA:1.10.630.10 112 469 1.6E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS49790 ddba02984b68581ca106b7e32205c718 487 Pfam PF00067 Cytochrome P450 264 459 2.0E-9 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 Gene3D G3DSA:3.30.565.10 200 367 4.1E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 SMART SM00387 259 369 2.3E-27 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 SMART SM00388 150 214 9.2E-19 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 Pfam PF00512 His Kinase A (phospho-acceptor) domain 150 214 2.8E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 PRINTS PR00344 Bacterial sensor protein C-terminal signature 353 366 1.6E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 PRINTS PR00344 Bacterial sensor protein C-terminal signature 296 310 1.6E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 PRINTS PR00344 Bacterial sensor protein C-terminal signature 330 348 1.6E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 Gene3D G3DSA:1.10.287.130 142 199 1.4E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 SUPERFAMILY SSF55874 204 367 2.17E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 SUPERFAMILY SSF47384 138 214 5.69E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS38365 c8fa29938092c353a32114601f68f992 370 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 261 368 5.3E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Gene3D G3DSA:2.60.120.260 37 180 2.6E-30 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Gene3D G3DSA:2.60.120.260 183 328 5.1E-19 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SUPERFAMILY SSF49785 41 175 3.47E-26 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SUPERFAMILY SSF49785 185 323 3.4E-15 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SUPERFAMILY SSF51126 706 1023 4.24E-37 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Pfam PF00754 F5/8 type C domain 196 319 1.8E-10 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Pfam PF00754 F5/8 type C domain 50 169 5.6E-21 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SUPERFAMILY SSF51126 1046 1110 3.98E-5 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00231 40 175 0.0011 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Pfam PF12708 Pectate lyase superfamily protein 725 987 7.7E-7 T 17-03-2017 IPR024535 Pectate lyase superfamily protein SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Pfam PF13229 Right handed beta helix region 1047 1127 1.3E-5 T 17-03-2017 SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Gene3D G3DSA:2.160.20.10 706 1112 9.8E-33 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Pfam PF07705 CARDB 441 541 1.8E-13 T 17-03-2017 IPR011635 CARDB domain SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 Pfam PF07705 CARDB 329 427 7.9E-20 T 17-03-2017 IPR011635 CARDB domain SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 895 917 89.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 1044 1066 1.9 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 1071 1094 390.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 828 859 6800.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 862 883 1900.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 977 1000 140.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 953 976 98.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS41070 33a8a2bf2601f9ac1e864ec3717b10ae 1139 SMART SM00710 919 941 230.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS42410 a671ed792ef1767650babc182a5d6f0b 333 SUPERFAMILY SSF52317 110 327 2.29E-46 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS42410 a671ed792ef1767650babc182a5d6f0b 333 Gene3D G3DSA:3.40.50.880 110 326 7.5E-37 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS42410 a671ed792ef1767650babc182a5d6f0b 333 Pfam PF06283 Trehalose utilisation 110 323 6.2E-81 T 17-03-2017 IPR029010 ThuA-like domain SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 Pfam PF01476 LysM domain 174 222 1.2E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 SUPERFAMILY SSF51261 239 378 6.8E-45 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 Gene3D G3DSA:1.10.530.10 24 121 1.2E-41 T 17-03-2017 SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 SMART SM00257 173 222 6.0E-4 T 17-03-2017 IPR018392 LysM domain SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 Pfam PF01551 Peptidase family M23 277 374 2.1E-32 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 Gene3D G3DSA:3.10.350.10 173 223 1.2E-8 T 17-03-2017 IPR018392 LysM domain SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 SUPERFAMILY SSF54106 174 222 3.14E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 Gene3D G3DSA:2.70.70.10 241 379 1.1E-43 T 17-03-2017 SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 SUPERFAMILY SSF53955 43 121 1.69E-31 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS44820 9c606a58678afe78ddb89d376eb9997b 385 Pfam PF06737 Transglycosylase-like domain 43 118 3.9E-34 T 17-03-2017 IPR010618 Transglycosylase-like SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 4 104 4.0E-12 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 SUPERFAMILY SSF56214 2 121 4.84E-24 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 TIGRFAM TIGR00556 pantethn_trn: phosphopantetheine--protein transferase domain 2 120 5.0E-23 T 17-03-2017 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 ProDom PD004282 TRANSFERASE SYNTHASE HOLO-ACYL-CARRIER-PROTEIN HOLO-ACP 4'-PHOSPHOPANTETHEINYL FATTY ACID METAL-BINDING MAGNESIUM LIPID 14 83 2.0E-10 T 17-03-2017 IPR004568 Phosphopantetheine-protein transferase domain GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 Hamap MF_00101 Holo-[acyl-carrier-protein] synthase [acpS]. 3 122 21.306 T 17-03-2017 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 Gene3D G3DSA:3.90.470.20 2 121 5.9E-37 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS31400 0e90163e13dd144a0ffdf586d2bdd04a 122 TIGRFAM TIGR00516 acpS: holo-[acyl-carrier-protein] synthase 2 121 6.3E-19 T 17-03-2017 IPR002582 Holo-[acyl carrier protein] synthase GO:0000287|GO:0006633|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1 SHXM_RS18535 b0b212bb95d842f89771e553df9845ca 98 Pfam PF02325 YGGT family 10 90 8.0E-13 T 17-03-2017 IPR003425 CCB3/YggT GO:0016020 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 Gene3D G3DSA:3.30.230.70 3 237 3.6E-31 T 17-03-2017 IPR027408 PNPase/RNase PH domain Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 ProSitePatterns PS01277 Ribonuclease PH signature. 117 130 - T 17-03-2017 IPR018336 Ribonuclease PH, conserved site SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 Hamap MF_00564 Ribonuclease PH [rph]. 2 240 47.553 T 17-03-2017 IPR002381 Ribonuclease phosphorolytic, bacterial-type GO:0000049|GO:0004549|GO:0008033 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 SUPERFAMILY SSF55666 156 240 1.31E-23 T 17-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 Pfam PF03725 3' exoribonuclease family, domain 2 162 225 3.7E-9 T 17-03-2017 IPR015847 Exoribonuclease, phosphorolytic domain 2 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 TIGRFAM TIGR01966 RNasePH: ribonuclease PH 3 239 1.5E-114 T 17-03-2017 IPR002381 Ribonuclease phosphorolytic, bacterial-type GO:0000049|GO:0004549|GO:0008033 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 Pfam PF01138 3' exoribonuclease family, domain 1 11 141 2.8E-24 T 17-03-2017 IPR001247 Exoribonuclease, phosphorolytic domain 1 Reactome: R-HSA-380994|Reactome: R-HSA-429958|Reactome: R-HSA-450385|Reactome: R-HSA-450513|Reactome: R-HSA-450604|Reactome: R-HSA-6791226 SHXM_RS23385 ab47c2ba21e6dd5b8fc16b6fa11974e8 243 SUPERFAMILY SSF54211 3 183 8.1E-47 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 109 128 7.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 86 94 7.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 28 39 7.0E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 Pfam PF00106 short chain dehydrogenase 3 147 1.4E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 SUPERFAMILY SSF51735 6 186 8.99E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 28 39 9.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 147 9.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 96 9.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 109 128 9.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08730 0642ac33e4197035f78cf0fd23f7d744 186 Gene3D G3DSA:3.40.50.720 5 186 3.8E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43600 fdc33bbb5b66be034e904b1183d091de 319 Gene3D G3DSA:2.40.50.140 88 136 1.1E-4 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS43600 fdc33bbb5b66be034e904b1183d091de 319 SUPERFAMILY SSF50249 166 294 1.88E-29 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS43600 fdc33bbb5b66be034e904b1183d091de 319 SUPERFAMILY SSF50249 8 140 5.48E-26 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS43600 fdc33bbb5b66be034e904b1183d091de 319 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 193 225 1.0E-7 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS43600 fdc33bbb5b66be034e904b1183d091de 319 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 229 292 4.7E-13 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS43600 fdc33bbb5b66be034e904b1183d091de 319 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 69 132 1.2E-11 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS39715 2124e4b959cbb85f6a486ddf2808a1e1 278 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 72 274 2.6E-67 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS39715 2124e4b959cbb85f6a486ddf2808a1e1 278 Gene3D G3DSA:3.90.850.10 66 277 2.3E-76 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS39715 2124e4b959cbb85f6a486ddf2808a1e1 278 SUPERFAMILY SSF56529 65 277 3.01E-71 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 Pfam PF01266 FAD dependent oxidoreductase 11 396 2.1E-52 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 Gene3D G3DSA:3.50.50.60 359 415 4.9E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 Gene3D G3DSA:3.50.50.60 115 136 4.9E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 Gene3D G3DSA:3.50.50.60 9 65 4.9E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 Gene3D G3DSA:3.50.50.60 191 271 4.9E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 SUPERFAMILY SSF54373 273 359 9.81E-11 T 17-03-2017 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 SUPERFAMILY SSF51905 114 272 1.29E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 SUPERFAMILY SSF51905 10 61 1.29E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07510 1bddcdd91d3631dd357082dc67f5805d 428 SUPERFAMILY SSF51905 359 421 1.29E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01210 011205f9baaef14f0eaa647609eecace 111 Pfam PF12840 Helix-turn-helix domain 19 73 2.0E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01210 011205f9baaef14f0eaa647609eecace 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 54 69 6.8E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS01210 011205f9baaef14f0eaa647609eecace 111 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 20 35 6.8E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS01210 011205f9baaef14f0eaa647609eecace 111 SMART SM00418 18 98 9.0E-4 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS01210 011205f9baaef14f0eaa647609eecace 111 SUPERFAMILY SSF46785 8 98 6.51E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01210 011205f9baaef14f0eaa647609eecace 111 Gene3D G3DSA:1.10.10.10 13 98 1.0E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00230 b19df263c4562067ad23048b7c0d336d 511 Gene3D G3DSA:1.10.443.10 328 442 8.2E-4 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS00230 b19df263c4562067ad23048b7c0d336d 511 SUPERFAMILY SSF56349 326 445 4.24E-5 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS31260 80e0c15226d57b359277911fe84617cf 60 Gene3D G3DSA:3.30.1390.20 1 59 2.8E-27 T 17-03-2017 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain SHXM_RS31260 80e0c15226d57b359277911fe84617cf 60 Hamap MF_01371_B 50S ribosomal protein L30 [rpmD]. 1 58 19.17 T 17-03-2017 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 SHXM_RS31260 80e0c15226d57b359277911fe84617cf 60 TIGRFAM TIGR01308 rpmD_bact: ribosomal protein uL30 4 58 2.5E-25 T 17-03-2017 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 SHXM_RS31260 80e0c15226d57b359277911fe84617cf 60 PIRSF PIRSF002211 1 60 1.5E-27 T 17-03-2017 IPR005996 Ribosomal protein L30, bacterial-type GO:0003735|GO:0006412|GO:0015934 SHXM_RS31260 80e0c15226d57b359277911fe84617cf 60 SUPERFAMILY SSF55129 1 60 7.72E-21 T 17-03-2017 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain SHXM_RS31260 80e0c15226d57b359277911fe84617cf 60 Pfam PF00327 Ribosomal protein L30p/L7e 4 54 8.0E-16 T 17-03-2017 IPR016082 Ribosomal protein L30, ferredoxin-like fold domain SHXM_RS49865 da231118827af239ce72e5b896a1c34b 287 PIRSF PIRSF011468 1 287 2.0E-149 T 17-03-2017 IPR010306 Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase GO:0016829|GO:0019700|GO:0051539 KEGG: 00440+4.7.1.1|MetaCyc: PWY-7399 SHXM_RS49865 da231118827af239ce72e5b896a1c34b 287 Pfam PF06007 Phosphonate metabolism protein PhnJ 7 277 4.8E-139 T 17-03-2017 IPR010306 Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase GO:0016829|GO:0019700|GO:0051539 KEGG: 00440+4.7.1.1|MetaCyc: PWY-7399 SHXM_RS47555 9cd12672db9d3f8c9db5ff95b9440f7c 370 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 4 348 1.7E-70 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS47555 9cd12672db9d3f8c9db5ff95b9440f7c 370 Gene3D G3DSA:3.20.20.70 2 362 3.7E-131 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS47555 9cd12672db9d3f8c9db5ff95b9440f7c 370 SUPERFAMILY SSF51395 2 364 1.78E-114 T 17-03-2017 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 Gene3D G3DSA:3.40.190.10 91 185 3.0E-17 T 17-03-2017 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 SUPERFAMILY SSF53850 91 301 6.52E-35 T 17-03-2017 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 SUPERFAMILY SSF46785 2 112 5.09E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 Gene3D G3DSA:1.10.10.10 2 88 2.4E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 2.1E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 2.1E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 2.1E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 Gene3D G3DSA:3.40.190.10 186 272 3.5E-28 T 17-03-2017 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 1.4E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS31555 72bdce63a8bd68069259dcd118ebaaf4 302 Pfam PF03466 LysR substrate binding domain 89 300 3.1E-40 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 241 427 1.5E-37 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 339 359 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 SUPERFAMILY SSF53067 4 235 1.04E-62 T 17-03-2017 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 Gene3D G3DSA:3.30.420.40 234 470 7.4E-62 T 17-03-2017 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 SUPERFAMILY SSF53067 235 469 6.91E-52 T 17-03-2017 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 Gene3D G3DSA:3.30.420.40 2 231 1.9E-64 T 17-03-2017 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 128 140 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 4 231 3.3E-51 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS49605 1e8fda71b70d07525ca2417e2ba80bf2 477 PIRSF PIRSF000538 1 474 3.7E-114 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 SUPERFAMILY SSF49785 3 171 3.61E-56 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 Pfam PF03561 Allantoicase repeat 189 323 3.3E-39 T 17-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 Pfam PF03561 Allantoicase repeat 16 167 1.8E-48 T 17-03-2017 IPR015908 Allantoicase domain GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 Gene3D G3DSA:2.60.120.260 3 171 3.7E-59 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 Gene3D G3DSA:2.60.120.260 180 326 1.9E-42 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 Hamap MF_00813 Probable allantoicase [alc]. 2 326 46.582 T 17-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 TIGRFAM TIGR02961 allantoicase: allantoicase 8 324 5.8E-119 T 17-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 PIRSF PIRSF016516 1 327 2.6E-103 T 17-03-2017 IPR005164 Allantoicase GO:0000256|GO:0004037 KEGG: 00230+3.5.3.4|MetaCyc: PWY-5697 SHXM_RS40895 7f1f61015fce9870a9fdaf4f1057fc25 399 SUPERFAMILY SSF49785 180 326 1.62E-41 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 36 60 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 Gene3D G3DSA:3.40.1190.20 34 315 9.3E-80 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 TIGRFAM TIGR03168 1-PFK: hexose kinase, 1-phosphofructokinase family 2 313 1.7E-89 T 17-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 254 267 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 Pfam PF00294 pfkB family carbohydrate kinase 12 294 4.7E-41 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 PIRSF PIRSF000535 1 316 2.9E-79 T 17-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 SHXM_RS25900 a6bc7c614b5b571a6b45f17ecab89d0b 320 SUPERFAMILY SSF53613 2 293 8.11E-61 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 SMART SM00493 261 337 3.3E-14 T 17-03-2017 IPR006171 Toprim domain SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 TIGRFAM TIGR01391 dnaG: DNA primase 5 416 5.5E-117 T 17-03-2017 IPR006295 DNA primase, DnaG GO:0003896|GO:0006269 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Gene3D G3DSA:3.40.1360.10 243 370 1.7E-40 T 17-03-2017 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 SMART SM00400 37 91 5.3E-32 T 17-03-2017 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Hamap MF_00974 DNA primase [dnaG]. 4 655 26.109 T 17-03-2017 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 SUPERFAMILY SSF56731 117 428 6.02E-95 T 17-03-2017 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 SMART SM00766 523 650 1.1E-10 T 17-03-2017 IPR013173 DNA primase DnaG, DnaB-binding domain GO:0003896|GO:0006269 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 PIRSF PIRSF002811 2 661 7.0E-163 T 17-03-2017 IPR030846 DNA primase DnaG, bacteria GO:0003896|GO:0006269|GO:0008270 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 SUPERFAMILY SSF57783 4 102 6.8E-31 T 17-03-2017 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Pfam PF01807 CHC2 zinc finger 7 101 3.6E-31 T 17-03-2017 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Pfam PF10410 DnaB-helicase binding domain of primase 373 425 8.0E-14 T 17-03-2017 IPR019475 DNA primase, DnaB-helicase binding domain GO:0016779 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Gene3D G3DSA:3.90.980.10 117 241 1.0E-40 T 17-03-2017 IPR013264 DNA primase, catalytic core, N-terminal SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Gene3D G3DSA:3.90.580.10 3 102 7.3E-35 T 17-03-2017 IPR002694 Zinc finger, CHC2-type GO:0003677|GO:0003896|GO:0006260|GO:0008270 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Pfam PF08278 DNA primase DnaG DnaB-binding 524 642 1.5E-13 T 17-03-2017 IPR013173 DNA primase DnaG, DnaB-binding domain GO:0003896|GO:0006269 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Gene3D G3DSA:1.20.50.20 372 427 3.4E-9 T 17-03-2017 SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Pfam PF13662 Toprim domain 262 332 4.2E-16 T 17-03-2017 IPR006171 Toprim domain SHXM_RS20605 2d5e377f5c8fe7856980392197d14571 671 Pfam PF08275 DNA primase catalytic core, N-terminal domain 127 253 1.4E-37 T 17-03-2017 IPR013264 DNA primase, catalytic core, N-terminal SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 Gene3D G3DSA:1.10.150.240 18 87 9.1E-6 T 17-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 SUPERFAMILY SSF56784 5 192 8.54E-54 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 42 187 7.0E-16 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 149 169 1.7E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 4 15 1.7E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 100 113 1.7E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 131 147 1.7E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 Gene3D G3DSA:3.40.50.1000 3 17 5.7E-41 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 Gene3D G3DSA:3.40.50.1000 91 191 5.7E-41 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42700 e7cdcceb3efdeaf1669fd27a4571c70c 227 Pfam PF13419 Haloacid dehalogenase-like hydrolase 7 187 4.2E-35 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 150 178 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 28 266 1.1E-48 T 17-03-2017 SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 TIGRFAM TIGR01963 PHB_DH: 3-hydroxybutyrate dehydrogenase 22 268 1.3E-102 T 17-03-2017 IPR011294 3-hydroxybutyrate dehydrogenase GO:0003858|GO:0055114 SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 23 40 2.6E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 229 249 2.6E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 137 153 2.6E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 90 101 2.6E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 163 182 2.6E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 184 201 2.6E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 143 151 9.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 163 182 9.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 90 101 9.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 Gene3D G3DSA:3.40.50.720 19 266 3.7E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43360 6185ebb36d0ec29a4081e59339ebf57e 268 SUPERFAMILY SSF51735 16 267 5.39E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03650 313e717cac97ea5f18114e46eb35307a 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 61 1.2E-4 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03650 313e717cac97ea5f18114e46eb35307a 216 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 71 185 4.4E-6 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS03650 313e717cac97ea5f18114e46eb35307a 216 Gene3D G3DSA:1.10.10.60 4 65 4.1E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03650 313e717cac97ea5f18114e46eb35307a 216 SUPERFAMILY SSF46689 5 70 2.38E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03650 313e717cac97ea5f18114e46eb35307a 216 Gene3D G3DSA:1.10.357.10 66 208 4.2E-15 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03650 313e717cac97ea5f18114e46eb35307a 216 SUPERFAMILY SSF48498 78 207 3.67E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS06185 fc75797eead5f8d2d30a50fbf0415396 135 Gene3D G3DSA:2.40.350.10 1 135 2.3E-38 T 17-03-2017 IPR023159 SO1590-like domain SHXM_RS06185 fc75797eead5f8d2d30a50fbf0415396 135 SUPERFAMILY SSF159238 1 135 7.32E-33 T 17-03-2017 IPR023159 SO1590-like domain SHXM_RS06185 fc75797eead5f8d2d30a50fbf0415396 135 Pfam PF11528 Protein of unknown function (DUF3224) 6 133 2.4E-36 T 17-03-2017 IPR021607 Protein of unknown function DUF3224 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF07721 Tetratricopeptide repeat 887 909 0.96 T 17-03-2017 IPR011717 Tetratricopeptide TPR-4 GO:0042802 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF07721 Tetratricopeptide repeat 844 867 0.054 T 17-03-2017 IPR011717 Tetratricopeptide TPR-4 GO:0042802 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF48452 965 1058 2.02E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 759 792 14.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 591 624 140.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 549 582 200.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 717 750 270.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 507 540 58.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 465 498 210.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 969 1002 86.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 633 666 0.23 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SMART SM00028 675 708 100.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF48452 426 535 2.99E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Gene3D G3DSA:1.25.40.10 713 1037 4.5E-28 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF48452 713 842 9.17E-16 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF48452 501 618 3.86E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF48452 878 995 6.96E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF00931 NB-ARC domain 78 253 1.8E-6 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Gene3D G3DSA:1.25.40.10 603 701 6.2E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Gene3D G3DSA:1.25.40.10 428 602 4.5E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13424 Tetratricopeptide repeat 466 538 2.0E-12 T 17-03-2017 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13424 Tetratricopeptide repeat 760 831 3.2E-12 T 17-03-2017 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13424 Tetratricopeptide repeat 632 702 5.1E-13 T 17-03-2017 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13424 Tetratricopeptide repeat 554 621 7.9E-14 T 17-03-2017 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13424 Tetratricopeptide repeat 975 1037 1.9E-11 T 17-03-2017 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF48452 627 745 1.69E-17 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13374 Tetratricopeptide repeat 926 966 0.002 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 Pfam PF13374 Tetratricopeptide repeat 716 757 0.0023 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS26715 7b33ddd484baa171815084cd4e06dd5c 1070 SUPERFAMILY SSF52540 51 269 1.25E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 Gene3D G3DSA:2.170.16.10 1758 1904 5.2E-22 T 17-03-2017 IPR028992 Hedgehog/Intein (Hint) domain SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1066 1095 1.5E-6 T 17-03-2017 IPR006530 YD repeat SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1026 1062 2.6E-5 T 17-03-2017 IPR006530 YD repeat SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 SMART SM00306 1758 1861 7.2E-6 T 17-03-2017 IPR003587 Hint domain N-terminal Reactome: R-HSA-373080|Reactome: R-HSA-5358346|Reactome: R-HSA-5362798|Reactome: R-HSA-5632681|Reactome: R-HSA-5658034 SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 SUPERFAMILY SSF51294 1761 1902 1.31E-19 T 17-03-2017 IPR028992 Hedgehog/Intein (Hint) domain SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 Pfam PF05593 RHS Repeat 1024 1059 4.2E-8 T 17-03-2017 IPR031325 RHS repeat SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 Pfam PF05593 RHS Repeat 1066 1103 2.7E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 Pfam PF07591 Pretoxin HINT domain 1770 1903 5.5E-19 T 17-03-2017 SHXM_RS15390 bfe29c3d4bcfee9e7d2d7c543a21058c 2029 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 1519 1598 8.3E-16 T 17-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 SUPERFAMILY SSF56003 155 698 2.36E-157 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.30.365.10 551 696 1.6E-57 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.30.365.10 346 432 1.6E-57 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 SUPERFAMILY SSF54665 6 129 4.58E-33 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.30.365.10 166 270 2.9E-36 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.30.365.10 433 526 1.6E-23 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 152 636 3.0E-110 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.90.1170.50 5 113 1.2E-32 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 22 124 9.0E-22 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 SMART SM01008 22 126 1.2E-32 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.30.365.10 273 297 1.7E-9 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03550 2c40801049bc31855b3052b83493d0e5 700 Gene3D G3DSA:3.30.365.10 114 165 1.7E-9 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS43680 df34b52551aab29115f3eec617901c28 1203 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 7 185 3.0E-57 T 17-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS43680 df34b52551aab29115f3eec617901c28 1203 Pfam PF02538 Hydantoinase B/oxoprolinase 691 1197 2.5E-199 T 17-03-2017 IPR003692 Hydantoinase B/oxoprolinase GO:0003824 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS43680 df34b52551aab29115f3eec617901c28 1203 Pfam PF01968 Hydantoinase/oxoprolinase 205 492 1.3E-110 T 17-03-2017 IPR002821 Hydantoinase/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS10840 731abc63bb5747394cd63c723aaf94e4 271 PIRSF PIRSF017393 2 271 1.1E-105 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS10840 731abc63bb5747394cd63c723aaf94e4 271 Pfam PF04672 S-adenosyl methyltransferase 6 271 5.0E-118 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS10840 731abc63bb5747394cd63c723aaf94e4 271 SUPERFAMILY SSF53335 15 254 8.74E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10840 731abc63bb5747394cd63c723aaf94e4 271 Gene3D G3DSA:3.40.50.150 3 271 8.2E-115 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 TIGRFAM TIGR00612 ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 18 360 1.4E-127 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 Pfam PF04551 GcpE protein 21 361 2.2E-133 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 Gene3D G3DSA:3.20.20.70 52 168 2.9E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 PIRSF PIRSF004640 12 372 1.2E-143 T 17-03-2017 IPR016425 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial GO:0005506|GO:0008299|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 Hamap MF_00159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) [ispG]. 16 367 33.612 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 SUPERFAMILY SSF56014 276 362 2.42E-11 T 17-03-2017 SHXM_RS16435 0af3b46b002cca73b373fbb0a1f568e7 383 SUPERFAMILY SSF51717 47 219 2.12E-10 T 17-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS38615 fcf4b747fe1dde44de8dc43d02da4ba6 419 Gene3D G3DSA:1.20.1250.20 226 409 1.5E-10 T 17-03-2017 SHXM_RS38615 fcf4b747fe1dde44de8dc43d02da4ba6 419 Gene3D G3DSA:1.20.1250.20 22 201 2.8E-18 T 17-03-2017 SHXM_RS38615 fcf4b747fe1dde44de8dc43d02da4ba6 419 SUPERFAMILY SSF103473 20 401 3.79E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS38615 fcf4b747fe1dde44de8dc43d02da4ba6 419 Pfam PF07690 Major Facilitator Superfamily 25 354 2.0E-33 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 Gene3D G3DSA:1.10.260.40 7 68 5.5E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 SUPERFAMILY SSF48498 161 257 8.35E-21 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 SUPERFAMILY SSF46689 88 165 5.64E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 SUPERFAMILY SSF47413 9 67 1.3E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 Pfam PF00440 Bacterial regulatory proteins, tetR family 95 141 3.3E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 SMART SM00530 10 65 3.0E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 Pfam PF01381 Helix-turn-helix 12 65 4.1E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 Gene3D G3DSA:1.10.357.10 87 258 1.7E-40 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 Pfam PF13977 Bacterial transcriptional repressor 163 279 1.1E-26 T 17-03-2017 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 95 108 4.4E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32040 fc5f1314d560be84d0249511c9593789 313 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 116 139 4.4E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 Gene3D G3DSA:3.40.366.10 1 108 7.4E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 Gene3D G3DSA:3.40.366.10 174 259 7.4E-66 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 SUPERFAMILY SSF55048 113 174 1.01E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 SUPERFAMILY SSF52151 175 259 4.97E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 SUPERFAMILY SSF52151 1 114 4.97E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 Pfam PF00698 Acyl transferase domain 1 255 8.6E-46 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 Gene3D G3DSA:3.30.70.250 113 173 3.3E-8 T 17-03-2017 SHXM_RS05345 f8a83de67c90eaa903bdc39bdb262ded 259 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1 257 4.7E-94 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07730 2d6bb050957426f546c7dd751930194d 274 SUPERFAMILY SSF161098 5 273 4.58E-67 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07730 2d6bb050957426f546c7dd751930194d 274 Gene3D G3DSA:1.10.3720.10 6 261 3.7E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07730 2d6bb050957426f546c7dd751930194d 274 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 85 263 6.7E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11895 091a49d4474eb43ee075096e927fca76 324 Gene3D G3DSA:1.10.10.10 2 58 5.9E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11895 091a49d4474eb43ee075096e927fca76 324 Pfam PF00891 O-methyltransferase 136 252 1.0E-11 T 17-03-2017 IPR001077 O-methyltransferase, family 2 GO:0008171 SHXM_RS11895 091a49d4474eb43ee075096e927fca76 324 SUPERFAMILY SSF46785 3 58 8.37E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11895 091a49d4474eb43ee075096e927fca76 324 SUPERFAMILY SSF53335 109 291 9.91E-20 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11895 091a49d4474eb43ee075096e927fca76 324 Gene3D G3DSA:3.40.50.150 106 298 3.0E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 Pfam PF13527 Acetyltransferase (GNAT) domain 9 132 1.3E-26 T 17-03-2017 SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 Gene3D G3DSA:3.40.630.30 139 299 2.7E-28 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 Pfam PF13530 Sterol carrier protein domain 184 412 1.3E-45 T 17-03-2017 IPR025559 Enhanced intracellular survival protein domain SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 Gene3D G3DSA:3.40.630.30 9 132 5.2E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 SUPERFAMILY SSF55729 22 308 2.05E-54 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 Hamap MF_01812 UPF0256 protein . 1 415 46.64 T 17-03-2017 IPR022902 Uncharacterised protein family UPF0256 SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 SUPERFAMILY SSF55718 311 415 5.49E-20 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS30045 1ea7bdc9fe819bc9dab2b4eb33f20d38 415 Gene3D G3DSA:3.30.1050.10 312 403 1.9E-15 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 SMART SM00065 28 180 4.4E-17 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 327 341 2.4E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 370 383 2.4E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 PRINTS PR00344 Bacterial sensor protein C-terminal signature 346 364 2.4E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 SUPERFAMILY SSF55781 18 183 2.01E-28 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 Gene3D G3DSA:3.30.565.10 276 383 3.9E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 SMART SM00387 291 385 1.6E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 Pfam PF13185 GAF domain 27 170 5.3E-18 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 295 383 2.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 Pfam PF07730 Histidine kinase 187 254 9.4E-18 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 SUPERFAMILY SSF55874 255 383 4.32E-21 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17255 920b817c50e0cb56fabbadd09e2f99ca 385 Gene3D G3DSA:3.30.450.40 22 178 6.4E-29 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS28090 73974f8344503d3bdd90009915af8166 237 TIGRFAM TIGR00138 rsmG_gidB: 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG 27 193 1.3E-37 T 17-03-2017 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SHXM_RS28090 73974f8344503d3bdd90009915af8166 237 Pfam PF02527 rRNA small subunit methyltransferase G 24 198 9.7E-54 T 17-03-2017 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SHXM_RS28090 73974f8344503d3bdd90009915af8166 237 Gene3D G3DSA:3.40.50.150 26 212 1.4E-61 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS28090 73974f8344503d3bdd90009915af8166 237 SUPERFAMILY SSF53335 27 206 1.58E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS28090 73974f8344503d3bdd90009915af8166 237 Hamap MF_00074 Ribosomal RNA small subunit methyltransferase G [rsmG]. 14 209 23.919 T 17-03-2017 IPR003682 rRNA small subunit methyltransferase G GO:0005737|GO:0006364|GO:0008649 SHXM_RS29405 78301a8bc66e49ee82b2fbba7f13d84b 262 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 26 157 2.6E-20 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS29405 78301a8bc66e49ee82b2fbba7f13d84b 262 Pfam PF07398 MDMPI C-terminal domain 172 255 7.6E-7 T 17-03-2017 IPR010872 MDMPI C-terminal SHXM_RS29405 78301a8bc66e49ee82b2fbba7f13d84b 262 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 23 233 2.8E-22 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS29405 78301a8bc66e49ee82b2fbba7f13d84b 262 Gene3D G3DSA:1.20.120.450 18 100 2.9E-10 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS29405 78301a8bc66e49ee82b2fbba7f13d84b 262 SUPERFAMILY SSF109854 9 164 4.73E-20 T 17-03-2017 SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 SUPERFAMILY SSF51182 57 185 3.06E-23 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 Gene3D G3DSA:2.60.120.10 100 188 2.2E-25 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 SUPERFAMILY SSF47413 9 74 1.53E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 Pfam PF07883 Cupin domain 115 182 1.2E-15 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 SMART SM00530 14 69 4.4E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 Gene3D G3DSA:1.10.260.40 5 76 1.6E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10400 93a178aeba8a86fd7ec92de164457dc8 190 Pfam PF01381 Helix-turn-helix 15 68 8.7E-13 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS29970 9280852ea99b5c60a849c3749efe8b8b 174 Pfam PF01661 Macro domain 20 137 1.0E-37 T 17-03-2017 IPR002589 Macro domain SHXM_RS29970 9280852ea99b5c60a849c3749efe8b8b 174 SMART SM00506 3 137 1.5E-44 T 17-03-2017 IPR002589 Macro domain SHXM_RS29970 9280852ea99b5c60a849c3749efe8b8b 174 Gene3D G3DSA:3.40.220.10 3 169 9.4E-59 T 17-03-2017 SHXM_RS29970 9280852ea99b5c60a849c3749efe8b8b 174 SUPERFAMILY SSF52949 3 170 1.06E-52 T 17-03-2017 SHXM_RS05860 75e27e581b5db32c69b057ddae358ca5 174 TIGRFAM TIGR02241 TIGR02241: conserved hypothetical phage tail region protein 12 158 2.4E-39 T 17-03-2017 IPR011747 Conserved hypothetical protein CHP02241 SHXM_RS05860 75e27e581b5db32c69b057ddae358ca5 174 Pfam PF06841 T4-like virus tail tube protein gp19 15 157 8.0E-39 T 17-03-2017 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 Gene3D G3DSA:1.10.10.60 3 51 1.0E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 SUPERFAMILY SSF46689 3 67 1.23E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 13 26 3.4E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 34 57 3.4E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 56 1.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 Gene3D G3DSA:1.10.357.10 54 186 1.4E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 Pfam PF16859 Bacterial transcriptional repressor C-terminal 71 181 5.1E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11110 b5e64a976e6abadf7c9a7632c7575ca2 197 SUPERFAMILY SSF48498 71 186 4.45E-25 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 PRINTS PR00502 NUDIX hydrolase family signature 224 238 4.5E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 PRINTS PR00502 NUDIX hydrolase family signature 238 253 4.5E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 SUPERFAMILY SSF55811 199 327 1.11E-20 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 Pfam PF13671 AAA domain 3 144 1.1E-9 T 17-03-2017 SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 Pfam PF00293 NUDIX domain 200 314 3.4E-14 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 Gene3D G3DSA:3.90.79.10 200 329 5.9E-20 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 SUPERFAMILY SSF52540 2 183 4.95E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43195 93247294c0425b5645e6c8ca265e3aaa 344 Gene3D G3DSA:3.40.50.300 3 181 5.4E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 ProSitePatterns PS00211 ABC transporters family signature. 170 184 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 SMART SM00382 64 249 8.5E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 SUPERFAMILY SSF52540 38 276 1.36E-84 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 Pfam PF00005 ABC transporter 56 197 1.6E-34 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 Pfam PF08402 TOBE domain 313 386 7.2E-12 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 Gene3D G3DSA:3.40.50.300 33 271 1.8E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01665 52124c88e428357fa52ecdec24560f56 392 SUPERFAMILY SSF50331 273 386 1.76E-13 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 Pfam PF01467 Cytidylyltransferase-like 16 142 1.7E-16 T 17-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 TIGRFAM TIGR01510 coaD_prev_kdtB: pantetheine-phosphate adenylyltransferase 13 165 3.3E-58 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 59 83 1.2E-47 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 30 51 1.2E-47 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 121 143 1.2E-47 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 95 111 1.2E-47 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 PRINTS PR01020 Lipopolysaccharide core biosynthesis protein signature 12 30 1.2E-47 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 SUPERFAMILY SSF52374 12 165 2.47E-43 T 17-03-2017 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 Hamap MF_00151 Phosphopantetheine adenylyltransferase [coaD]. 12 167 34.117 T 17-03-2017 IPR001980 Coenzyme A biosynthesis protein GO:0004595|GO:0015937 KEGG: 00770+2.7.7.3 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 13 67 1.0E-14 T 17-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 Gene3D G3DSA:3.40.50.620 12 164 3.2E-50 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS36435 4727944a34c2d6e84278ffb3fb5d1f5d 169 ProDom PD016147 LIGASE LYASE CITRATE PRO-3S-LYASE SYNTHETASE TRANSFERASE CYTIDYLTRANSFERASE-RELATED:CITRATE ACETATE:SH-CITRATE CITC PLASMID 21 76 0.004 T 17-03-2017 SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 Gene3D G3DSA:3.40.190.10 576 691 2.1E-15 T 17-03-2017 SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 SUPERFAMILY SSF53850 395 926 6.15E-86 T 17-03-2017 SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 SUPERFAMILY SSF52129 10 224 6.8E-7 T 17-03-2017 IPR029030 Caspase-like domain SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 445 840 4.3E-65 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 Gene3D G3DSA:3.10.105.10 692 896 1.9E-37 T 17-03-2017 SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 Gene3D G3DSA:3.90.76.10 408 575 9.3E-30 T 17-03-2017 SHXM_RS32610 59bb5dae7e1c2f2179a62531f3637179 930 Pfam PF00656 Caspase domain 11 154 2.3E-7 T 17-03-2017 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 Gene3D G3DSA:2.40.30.10 233 319 5.2E-12 T 17-03-2017 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 Pfam PF01794 Ferric reductase like transmembrane component 65 186 2.9E-16 T 17-03-2017 IPR013130 Ferric reductase transmembrane component-like domain SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 Gene3D G3DSA:3.40.50.80 320 450 1.9E-27 T 17-03-2017 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 PRINTS PR00410 Phenol hydroxylase reductase family signature 338 357 5.8E-8 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 PRINTS PR00410 Phenol hydroxylase reductase family signature 422 430 5.8E-8 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 PRINTS PR00410 Phenol hydroxylase reductase family signature 322 331 5.8E-8 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 Pfam PF00175 Oxidoreductase NAD-binding domain 339 435 9.9E-10 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 SUPERFAMILY SSF63380 231 327 6.27E-15 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS12895 ea295ce78220793fea020c7d1c4cad9d 456 SUPERFAMILY SSF52343 317 452 3.27E-28 T 17-03-2017 SHXM_RS41780 75683e3959625c871b31a2c2e944e2b9 108 TIGRFAM TIGR01374 soxD: sarcosine oxidase, delta subunit family 3 85 6.6E-38 T 17-03-2017 IPR006279 Sarcosine oxidase, delta subunit, heterotetrameric GO:0008115|GO:0046653 KEGG: 00260+1.5.3.1|MetaCyc: PWY-3661|MetaCyc: PWY-4722 SHXM_RS41780 75683e3959625c871b31a2c2e944e2b9 108 Pfam PF04267 Sarcosine oxidase, delta subunit family 3 83 6.1E-37 T 17-03-2017 IPR006279 Sarcosine oxidase, delta subunit, heterotetrameric GO:0008115|GO:0046653 KEGG: 00260+1.5.3.1|MetaCyc: PWY-3661|MetaCyc: PWY-4722 SHXM_RS33640 f09459bdfe654c6c0256f17fccc4e2a3 118 Pfam PF02467 Transcription factor WhiB 27 95 1.1E-21 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS33640 f09459bdfe654c6c0256f17fccc4e2a3 118 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 9 103 18.464 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 Gene3D G3DSA:3.90.1260.10 176 373 3.7E-61 T 17-03-2017 IPR024074 Argininosuccinate synthetase, catalytic/multimerisation domain body GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 Pfam PF00764 Arginosuccinate synthase 16 404 1.8E-55 T 17-03-2017 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 ProSitePatterns PS00565 Argininosuccinate synthase signature 2. 129 140 - T 17-03-2017 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 SUPERFAMILY SSF69864 190 436 6.15E-74 T 17-03-2017 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 Gene3D G3DSA:1.10.287.400 377 438 7.4E-29 T 17-03-2017 IPR024073 Argininosuccinate synthetase mutimerisation domain, C-terminal tail GO:0042803 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 ProSitePatterns PS00564 Argininosuccinate synthase signature 1. 17 25 - T 17-03-2017 IPR018223 Argininosuccinate synthase, conserved site GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 TIGRFAM TIGR00032 argG: argininosuccinate synthase 13 420 6.1E-137 T 17-03-2017 IPR001518 Argininosuccinate synthase GO:0004055|GO:0005524|GO:0006526 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 SUPERFAMILY SSF52402 5 185 3.2E-30 T 17-03-2017 SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 Gene3D G3DSA:3.40.50.620 4 175 1.1E-39 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS05450 47af94f86738a80b31314ca46553b860 482 Hamap MF_00581 Argininosuccinate synthase [argG]. 1 473 79.099 T 17-03-2017 IPR023437 Argininosuccinate synthase, type 2 subfamily GO:0004055 KEGG: 00220+6.3.4.5|KEGG: 00250+6.3.4.5|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS29490 baf0d8bbe2e19e9d60c778a8318b5829 280 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 48 64 9.8E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29490 baf0d8bbe2e19e9d60c778a8318b5829 280 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 34 48 9.8E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29490 baf0d8bbe2e19e9d60c778a8318b5829 280 SMART SM00345 15 74 9.6E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29490 baf0d8bbe2e19e9d60c778a8318b5829 280 SUPERFAMILY SSF46785 4 78 6.27E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29490 baf0d8bbe2e19e9d60c778a8318b5829 280 Pfam PF00392 Bacterial regulatory proteins, gntR family 12 74 1.5E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29490 baf0d8bbe2e19e9d60c778a8318b5829 280 Gene3D G3DSA:1.10.10.10 3 78 1.2E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33100 fedc5f8de305cc91838d3bd99991b539 249 Pfam PF10138 vWA found in TerF C terminus 48 246 1.7E-67 T 17-03-2017 IPR019303 vWA found in TerF C terminus SHXM_RS33100 fedc5f8de305cc91838d3bd99991b539 249 Gene3D G3DSA:3.40.50.410 50 187 2.5E-7 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS33100 fedc5f8de305cc91838d3bd99991b539 249 SMART SM00327 48 214 1.1E-7 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS33100 fedc5f8de305cc91838d3bd99991b539 249 SUPERFAMILY SSF53300 48 202 6.38E-17 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS19300 141a51185d632f89b653ae7cbf14596e 383 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 74 369 8.3E-71 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS19300 141a51185d632f89b653ae7cbf14596e 383 SUPERFAMILY SSF53686 13 381 9.17E-88 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS19300 141a51185d632f89b653ae7cbf14596e 383 Gene3D G3DSA:3.40.50.1100 141 380 3.4E-57 T 17-03-2017 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 SUPERFAMILY SSF46977 508 651 4.84E-38 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 Pfam PF02910 Fumarate reductase flavoprotein C-term 517 651 1.4E-33 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 Gene3D G3DSA:3.90.700.10 281 410 4.2E-18 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 Gene3D G3DSA:3.50.50.60 40 280 3.0E-76 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 Gene3D G3DSA:3.50.50.60 412 464 3.0E-76 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 50 69 1.0E-6 T 17-03-2017 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 419 441 1.0E-6 T 17-03-2017 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 Pfam PF00890 FAD binding domain 50 455 2.8E-60 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 TIGRFAM TIGR01811 sdhA_Bsu: succinate dehydrogenase or fumarate reductase, flavoprotein subunit 50 651 0.0 T 17-03-2017 IPR011280 Succinate dehydrogenase/fumarate reductase flavoprotein subunit, low-GC Gram-positive bacteria KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 Gene3D G3DSA:1.20.58.100 489 606 1.3E-30 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 SUPERFAMILY SSF56425 275 417 4.49E-33 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 SUPERFAMILY SSF51905 43 291 5.05E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05155 60c11d171c4c41bc5687ad348e0c34b2 652 SUPERFAMILY SSF51905 420 468 5.05E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 6 380 8.0E-137 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 PIRSF PIRSF000429 2 382 7.6E-127 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 ProSitePatterns PS00737 Thiolases signature 2. 328 344 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 SUPERFAMILY SSF53901 4 259 4.12E-74 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 Pfam PF00108 Thiolase, N-terminal domain 5 252 1.5E-65 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 Gene3D G3DSA:3.40.47.10 266 381 7.2E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 Gene3D G3DSA:3.40.47.10 155 192 7.2E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 Gene3D G3DSA:3.40.47.10 4 124 1.6E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 Gene3D G3DSA:3.40.47.10 193 265 1.6E-66 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 Pfam PF02803 Thiolase, C-terminal domain 259 381 6.1E-47 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS10650 a760cbccb510ae9a210ff6f110161a66 382 SUPERFAMILY SSF53901 260 381 4.16E-45 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 Pfam PF00561 alpha/beta hydrolase fold 30 261 1.4E-24 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00412 Epoxide hydrolase signature 104 117 2.5E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00412 Epoxide hydrolase signature 271 293 2.5E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00412 Epoxide hydrolase signature 118 131 2.5E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00412 Epoxide hydrolase signature 36 54 2.5E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 SUPERFAMILY SSF53474 5 296 2.03E-69 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 Gene3D G3DSA:3.40.50.1820 5 294 7.6E-62 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00111 Alpha/beta hydrolase fold signature 118 131 4.6E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00111 Alpha/beta hydrolase fold signature 104 117 4.6E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19660 5fbd870d6eb3d732d395b71d7d51a795 300 PRINTS PR00111 Alpha/beta hydrolase fold signature 55 70 4.6E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09370 f2784e0566a34d5df0983777f92055e1 148 Pfam PF13358 DDE superfamily endonuclease 4 116 3.5E-27 T 17-03-2017 SHXM_RS09370 f2784e0566a34d5df0983777f92055e1 148 Gene3D G3DSA:3.30.420.10 25 132 2.1E-6 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09370 f2784e0566a34d5df0983777f92055e1 148 SUPERFAMILY SSF53098 25 136 6.57E-6 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 Gene3D G3DSA:3.40.50.720 1 257 4.9E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 175 194 4.6E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 164 4.6E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 89 100 4.6E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 196 213 8.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 166 8.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 226 246 8.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 89 100 8.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 194 8.9E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 50 257 3.5E-27 T 17-03-2017 SHXM_RS04500 2489192f0e16d100e7e2d646a18fbdbc 259 SUPERFAMILY SSF51735 1 257 1.19E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40095 3b9b6f4481411587cd011e5f196d5a04 329 SUPERFAMILY SSF53098 167 287 2.28E-7 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 TIGRFAM TIGR00131 gal_kin: galactokinase 23 388 2.6E-88 T 17-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 SUPERFAMILY SSF54211 20 224 1.75E-58 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 Gene3D G3DSA:3.30.230.10 20 233 7.1E-70 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PIRSF PIRSF000530 6 410 6.1E-119 T 17-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00959 Mevalonate kinase family signature 141 163 4.9E-41 T 17-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00959 Mevalonate kinase family signature 356 373 4.9E-41 T 17-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00959 Mevalonate kinase family signature 184 203 4.9E-41 T 17-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00959 Mevalonate kinase family signature 38 62 4.9E-41 T 17-03-2017 IPR006206 Mevalonate/galactokinase GO:0005524|GO:0005737|GO:0008152|GO:0016301|GO:0016773 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 Hamap MF_00246 Galactokinase [galK]. 38 409 40.421 T 17-03-2017 IPR022963 Galactokinase, bacterial GO:0004335|GO:0006012 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 Pfam PF00288 GHMP kinases N terminal domain 136 202 4.6E-17 T 17-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 Pfam PF08544 GHMP kinases C terminal 309 388 2.5E-11 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 Pfam PF10509 Galactokinase galactose-binding signature 24 71 1.2E-20 T 17-03-2017 IPR019539 Galactokinase galactose-binding domain KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 ProSitePatterns PS00627 GHMP kinases putative ATP-binding domain. 143 154 - T 17-03-2017 IPR006203 GHMP kinase, ATP-binding, conserved site GO:0005524 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00473 Galactokinase signature 40 58 4.2E-24 T 17-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00473 Galactokinase signature 293 307 4.2E-24 T 17-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00473 Galactokinase signature 111 122 4.2E-24 T 17-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 PRINTS PR00473 Galactokinase signature 134 152 4.2E-24 T 17-03-2017 IPR000705 Galactokinase GO:0004335|GO:0005524|GO:0006012|GO:0046835 KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 Gene3D G3DSA:3.30.70.890 234 408 6.6E-54 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 ProSitePatterns PS00106 Galactokinase signature. 40 51 - T 17-03-2017 IPR019741 Galactokinase, conserved site KEGG: 00052+2.7.1.6|KEGG: 00520+2.7.1.6|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6527 SHXM_RS32725 47803a7ef5e76e18590799977f28bbbf 410 SUPERFAMILY SSF55060 229 409 1.25E-45 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 Pfam PF01266 FAD dependent oxidoreductase 8 340 4.6E-51 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 SUPERFAMILY SSF51971 5 225 1.18E-36 T 17-03-2017 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 SUPERFAMILY SSF51971 290 345 1.18E-36 T 17-03-2017 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 Gene3D G3DSA:3.30.9.10 202 302 2.2E-8 T 17-03-2017 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 SUPERFAMILY SSF54373 246 305 7.85E-5 T 17-03-2017 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 Gene3D G3DSA:3.50.50.60 7 81 8.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 Gene3D G3DSA:3.50.50.60 129 201 8.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS15485 2a6460a5b590e9598b65e0f3e914f3ad 373 Gene3D G3DSA:3.50.50.60 305 347 8.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 Pfam PF00005 ABC transporter 18 160 3.8E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 SUPERFAMILY SSF52540 3 242 3.64E-82 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 Gene3D G3DSA:3.40.50.300 3 236 3.7E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 ProSitePatterns PS00211 ABC transporters family signature. 133 147 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 SUPERFAMILY SSF50331 237 341 2.27E-12 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 Pfam PF08402 TOBE domain 271 341 2.1E-12 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS42435 2fc898dfa4eedaff46586ea9a06ad655 349 SMART SM00382 27 211 1.8E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07880 e92d709cddb924194cc7d463b3a49671 302 SUPERFAMILY SSF161098 64 267 5.76E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07880 e92d709cddb924194cc7d463b3a49671 302 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 64 127 3.4E-12 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS07880 e92d709cddb924194cc7d463b3a49671 302 Gene3D G3DSA:1.10.3720.10 62 281 9.6E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07880 e92d709cddb924194cc7d463b3a49671 302 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 85 281 6.4E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35215 b3659aafdbcf6f90667a8a0ffceb02eb 448 SUPERFAMILY SSF53383 31 433 4.95E-144 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS35215 b3659aafdbcf6f90667a8a0ffceb02eb 448 Pfam PF00464 Serine hydroxymethyltransferase 33 407 2.4E-130 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS35215 b3659aafdbcf6f90667a8a0ffceb02eb 448 Gene3D G3DSA:3.90.1150.10 308 433 2.5E-31 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS35215 b3659aafdbcf6f90667a8a0ffceb02eb 448 Gene3D G3DSA:3.40.640.10 61 307 6.3E-97 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS35215 b3659aafdbcf6f90667a8a0ffceb02eb 448 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 31 433 44.402 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS35215 b3659aafdbcf6f90667a8a0ffceb02eb 448 PIRSF PIRSF000412 17 440 2.0E-144 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.30.365.10 604 734 3.9E-55 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.30.365.10 348 437 3.9E-55 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 17 125 1.5E-18 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.30.365.10 115 167 1.1E-7 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.30.365.10 275 302 1.1E-7 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 SUPERFAMILY SSF56003 142 737 8.77E-163 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.30.365.10 439 603 3.2E-35 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.30.365.10 168 271 5.7E-33 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 SUPERFAMILY SSF54665 2 124 2.36E-30 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 154 677 1.9E-121 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 SMART SM01008 16 128 1.0E-25 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS03040 6f15af7ab070bab7fe7b455b10fe7ccb 742 Gene3D G3DSA:3.90.1170.50 1 114 3.1E-28 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 SUPERFAMILY SSF52172 1 130 1.85E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 216 3.5E-24 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 SMART SM00862 145 216 3.9E-27 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 Pfam PF00072 Response regulator receiver domain 4 112 4.0E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 SMART SM00448 1 112 7.1E-42 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 SUPERFAMILY SSF46894 119 216 3.97E-27 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 Gene3D G3DSA:3.40.50.2300 1 120 2.3E-40 T 17-03-2017 SHXM_RS35390 d24a0c71e98ae3940bdc6011cc4acbcb 218 Gene3D G3DSA:1.10.10.10 123 217 1.6E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19365 e35035e60b65c8d6dae51c0e5bc7187b 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 6.2E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19365 e35035e60b65c8d6dae51c0e5bc7187b 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 42 57 6.2E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19365 e35035e60b65c8d6dae51c0e5bc7187b 258 PRINTS PR00111 Alpha/beta hydrolase fold signature 86 99 6.2E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19365 e35035e60b65c8d6dae51c0e5bc7187b 258 SUPERFAMILY SSF53474 7 256 9.26E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19365 e35035e60b65c8d6dae51c0e5bc7187b 258 Pfam PF00561 alpha/beta hydrolase fold 18 244 6.9E-23 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS19365 e35035e60b65c8d6dae51c0e5bc7187b 258 Gene3D G3DSA:3.40.50.1820 11 256 3.3E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02905 e652713b357a6dc2199267acb1c19b83 149 SUPERFAMILY SSF46785 2 131 1.72E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02905 e652713b357a6dc2199267acb1c19b83 149 Pfam PF02082 Transcriptional regulator 1 81 2.6E-17 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS02905 e652713b357a6dc2199267acb1c19b83 149 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 1 129 1.4E-26 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS02905 e652713b357a6dc2199267acb1c19b83 149 Gene3D G3DSA:1.10.10.10 1 130 3.7E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45810 0856917f45e7156b120ccce0a420034e 317 SUPERFAMILY SSF51735 119 289 1.42E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45810 0856917f45e7156b120ccce0a420034e 317 SMART SM00829 15 314 7.0E-10 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45810 0856917f45e7156b120ccce0a420034e 317 SUPERFAMILY SSF50129 7 152 1.98E-25 T 17-03-2017 IPR011032 GroES-like SHXM_RS45810 0856917f45e7156b120ccce0a420034e 317 Gene3D G3DSA:3.90.180.10 9 151 9.1E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS45810 0856917f45e7156b120ccce0a420034e 317 Gene3D G3DSA:3.40.50.720 152 255 3.0E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45810 0856917f45e7156b120ccce0a420034e 317 Pfam PF13602 Zinc-binding dehydrogenase 201 314 1.9E-11 T 17-03-2017 SHXM_RS00610 5410be3911805eaec549c8a24eaf9e58 202 Pfam PF11706 CGNR zinc finger 158 197 3.7E-8 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS00610 5410be3911805eaec549c8a24eaf9e58 202 Gene3D G3DSA:1.10.3300.10 25 198 4.4E-37 T 17-03-2017 IPR023286 ABATE domain SHXM_RS00610 5410be3911805eaec549c8a24eaf9e58 202 SUPERFAMILY SSF160904 15 196 6.54E-40 T 17-03-2017 SHXM_RS00610 5410be3911805eaec549c8a24eaf9e58 202 Pfam PF07336 Putative stress-induced transcription regulator 25 153 1.9E-25 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS49315 c791ed1c6c4854ff71fc0219d1f70d6a 291 Gene3D G3DSA:3.40.50.150 39 234 4.1E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS49315 c791ed1c6c4854ff71fc0219d1f70d6a 291 Pfam PF13649 Methyltransferase domain 58 155 1.0E-17 T 17-03-2017 SHXM_RS49315 c791ed1c6c4854ff71fc0219d1f70d6a 291 SUPERFAMILY SSF53335 37 225 1.69E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 Gene3D G3DSA:1.20.120.530 101 232 6.7E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 Pfam PF07729 FCD domain 105 224 5.6E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 Gene3D G3DSA:1.10.10.10 5 72 1.2E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 SMART SM00345 13 71 7.7E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 SUPERFAMILY SSF46785 3 75 1.32E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 Pfam PF00392 Bacterial regulatory proteins, gntR family 12 71 5.3E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 SUPERFAMILY SSF48008 103 230 1.39E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS38020 fc0b2b8ee467c6505986ff163f8f0e1f 246 SMART SM00895 104 225 3.2E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 Gene3D G3DSA:2.40.50.140 17 94 1.1E-34 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 TIGRFAM TIGR03635 uS17_bact: ribosomal protein uS17 17 88 1.1E-34 T 17-03-2017 IPR019984 Ribosomal protein S17, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 Pfam PF00366 Ribosomal protein S17 22 89 1.7E-30 T 17-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 PRINTS PR00973 Ribosomal protein S17 family signature 78 85 1.4E-11 T 17-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 PRINTS PR00973 Ribosomal protein S17 family signature 36 59 1.4E-11 T 17-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 PRINTS PR00973 Ribosomal protein S17 family signature 68 78 1.4E-11 T 17-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 Hamap MF_01345_B 30S ribosomal protein S17 [rpsQ]. 15 93 25.108 T 17-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 SUPERFAMILY SSF50249 17 94 2.14E-30 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 ProSitePatterns PS00056 Ribosomal protein S17 signature. 68 80 - T 17-03-2017 IPR019979 Ribosomal protein S17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31210 3c240c5443cca2f2cb197cbd15e1a21b 95 ProDom PD001295 RIBOSOMAL S17 30S RIBONUCLEOPROTEIN RRNA-BINDING RNA-BINDING 40S S11 S17P S11 22 88 2.0E-32 T 17-03-2017 IPR000266 Ribosomal protein S17/S11 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS46395 54da1d3bc44bbab3b4da14c7e2e63988 628 Gene3D G3DSA:3.60.21.10 61 269 4.3E-14 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS46395 54da1d3bc44bbab3b4da14c7e2e63988 628 SUPERFAMILY SSF56300 64 309 1.88E-20 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS46395 54da1d3bc44bbab3b4da14c7e2e63988 628 Gene3D G3DSA:2.60.120.200 467 620 3.1E-22 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS46395 54da1d3bc44bbab3b4da14c7e2e63988 628 SUPERFAMILY SSF49899 373 621 9.04E-24 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS46395 54da1d3bc44bbab3b4da14c7e2e63988 628 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 457 620 6.7E-14 T 17-03-2017 SHXM_RS11940 d44ab738649160cbc2d9709961c7afd5 85 Gene3D G3DSA:1.10.150.20 3 79 1.5E-14 T 17-03-2017 SHXM_RS11940 d44ab738649160cbc2d9709961c7afd5 85 Pfam PF11731 Pathogenicity locus 4 82 1.0E-28 T 17-03-2017 IPR021725 Pathogenicity locus SHXM_RS45200 406ab9a41f2bea045470045e4ef942e4 265 Pfam PF03704 Bacterial transcriptional activator domain 125 226 2.1E-25 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS45200 406ab9a41f2bea045470045e4ef942e4 265 SUPERFAMILY SSF48452 126 227 6.5E-22 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS45200 406ab9a41f2bea045470045e4ef942e4 265 Gene3D G3DSA:1.25.40.10 133 208 5.9E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS45200 406ab9a41f2bea045470045e4ef942e4 265 SMART SM01043 90 231 6.5E-24 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS37850 ce5cea7ce79a4510046392fefb676bbb 367 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 9 230 7.3E-20 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS37850 ce5cea7ce79a4510046392fefb676bbb 367 SUPERFAMILY SSF53901 9 234 4.08E-33 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37850 ce5cea7ce79a4510046392fefb676bbb 367 Gene3D G3DSA:3.40.47.10 9 234 8.1E-27 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37850 ce5cea7ce79a4510046392fefb676bbb 367 SUPERFAMILY SSF53901 208 364 2.41E-8 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16510 322f99b1225fd9d39ffc31399673626e 449 Gene3D G3DSA:2.60.120.10 211 236 2.0E-66 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS16510 322f99b1225fd9d39ffc31399673626e 449 Gene3D G3DSA:2.60.120.10 297 417 2.0E-66 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS16510 322f99b1225fd9d39ffc31399673626e 449 SUPERFAMILY SSF51182 21 449 5.41E-163 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS16510 322f99b1225fd9d39ffc31399673626e 449 TIGRFAM TIGR01015 hmgA: homogentisate 1,2-dioxygenase 21 447 1.1E-213 T 17-03-2017 IPR005708 Homogentisate 1,2-dioxygenase GO:0004411|GO:0006559|GO:0006570|GO:0055114 KEGG: 00350+1.13.11.5|KEGG: 00643+1.13.11.5|Reactome: R-HSA-71182 SHXM_RS16510 322f99b1225fd9d39ffc31399673626e 449 Hamap MF_00334 Homogentisate 1,2-dioxygenase [hmgA]. 22 449 71.681 T 17-03-2017 IPR022950 Homogentisate 1,2-dioxygenase, bacterial GO:0004411|GO:0006559|GO:0006572|GO:0055114 KEGG: 00350+1.13.11.5|KEGG: 00643+1.13.11.5 SHXM_RS16510 322f99b1225fd9d39ffc31399673626e 449 Pfam PF04209 homogentisate 1,2-dioxygenase 23 447 2.7E-208 T 17-03-2017 IPR005708 Homogentisate 1,2-dioxygenase GO:0004411|GO:0006559|GO:0006570|GO:0055114 KEGG: 00350+1.13.11.5|KEGG: 00643+1.13.11.5|Reactome: R-HSA-71182 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 116 125 1.9E-11 T 17-03-2017 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 269 276 1.9E-11 T 17-03-2017 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 4 26 1.9E-11 T 17-03-2017 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 4 127 2.1E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 SUPERFAMILY SSF51905 237 298 1.55E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 SUPERFAMILY SSF51905 2 121 1.55E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 Gene3D G3DSA:3.50.50.60 249 297 2.3E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 Gene3D G3DSA:3.50.50.60 1 146 2.3E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 113 131 1.6E-7 T 17-03-2017 SHXM_RS32375 b1cfd8cdb5ab01a379d7324862e0b7be 331 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 1.6E-7 T 17-03-2017 SHXM_RS21330 278d5b1532d4831fc33b337f3362aac3 88 TIGRFAM TIGR00029 S20: ribosomal protein bS20 2 85 1.1E-23 T 17-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21330 278d5b1532d4831fc33b337f3362aac3 88 Gene3D G3DSA:1.20.58.110 3 86 2.3E-28 T 17-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21330 278d5b1532d4831fc33b337f3362aac3 88 Pfam PF01649 Ribosomal protein S20 2 83 6.8E-26 T 17-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21330 278d5b1532d4831fc33b337f3362aac3 88 Hamap MF_00500 30S ribosomal protein S20 [rpsT]. 1 85 16.497 T 17-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21330 278d5b1532d4831fc33b337f3362aac3 88 ProDom PD004231 RIBOSOMAL S20 30S RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN S20P SUBUNIT CHLOROPLAST DIRECT 14 87 7.0E-5 T 17-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21330 278d5b1532d4831fc33b337f3362aac3 88 SUPERFAMILY SSF46992 3 86 4.84E-27 T 17-03-2017 IPR002583 Ribosomal protein S20 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 PRINTS PR00412 Epoxide hydrolase signature 129 147 4.4E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 PRINTS PR00412 Epoxide hydrolase signature 203 216 4.4E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 PRINTS PR00412 Epoxide hydrolase signature 158 173 4.4E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 Gene3D G3DSA:3.40.50.1820 29 285 2.0E-81 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 PIRSF PIRSF001112 15 289 1.8E-72 T 17-03-2017 IPR016292 Epoxide hydrolase GO:0033961 KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 Pfam PF06441 Epoxide hydrolase N terminus 34 138 1.1E-26 T 17-03-2017 IPR010497 Epoxide hydrolase, N-terminal KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS47530 73b0ee911144c699625970cd40b32430 298 SUPERFAMILY SSF53474 28 285 3.8E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19555 fbc63cc1592017dd37906322396e11de 337 SUPERFAMILY SSF55347 135 297 5.89E-43 T 17-03-2017 SHXM_RS19555 fbc63cc1592017dd37906322396e11de 337 Gene3D G3DSA:3.30.360.10 151 332 4.0E-56 T 17-03-2017 SHXM_RS19555 fbc63cc1592017dd37906322396e11de 337 Gene3D G3DSA:3.40.50.720 5 150 2.3E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19555 fbc63cc1592017dd37906322396e11de 337 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 11 126 9.3E-23 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS19555 fbc63cc1592017dd37906322396e11de 337 SUPERFAMILY SSF51735 7 161 3.38E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 PIRSF PIRSF001112 6 388 9.3E-110 T 17-03-2017 IPR016292 Epoxide hydrolase GO:0033961 KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 Pfam PF06441 Epoxide hydrolase N terminus 9 114 3.9E-29 T 17-03-2017 IPR010497 Epoxide hydrolase, N-terminal KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 PRINTS PR00412 Epoxide hydrolase signature 135 150 3.1E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 PRINTS PR00412 Epoxide hydrolase signature 359 381 3.1E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 PRINTS PR00412 Epoxide hydrolase signature 106 124 3.1E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 PRINTS PR00412 Epoxide hydrolase signature 194 207 3.1E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 PRINTS PR00412 Epoxide hydrolase signature 328 344 3.1E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 SUPERFAMILY SSF53474 4 384 7.19E-101 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42025 1e51f279a4b067f281b8aa6e91a96fcd 391 Gene3D G3DSA:3.40.50.1820 6 387 3.3E-137 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14620 d24a985e67436c3ba8481d81477f7502 179 Pfam PF07332 Putative Actinobacterial Holin-X, holin superfamily III 17 93 3.0E-9 T 17-03-2017 IPR009937 Putative Actinobacterial Holin-X, holin superfamily III SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 ProSitePatterns PS00437 Catalase proximal heme-ligand signature. 354 362 - T 17-03-2017 IPR002226 Catalase haem-binding site GO:0020037 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 Gene3D G3DSA:3.40.50.880 535 695 2.3E-43 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 SUPERFAMILY SSF52317 533 694 5.29E-25 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 Pfam PF01965 DJ-1/PfpI family 537 645 1.5E-15 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PRINTS PR00067 Catalase signature 121 138 3.0E-70 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PRINTS PR00067 Catalase signature 37 60 3.0E-70 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PRINTS PR00067 Catalase signature 341 367 3.0E-70 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PRINTS PR00067 Catalase signature 100 118 3.0E-70 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PRINTS PR00067 Catalase signature 140 158 3.0E-70 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PRINTS PR00067 Catalase signature 309 336 3.0E-70 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 Pfam PF06628 Catalase-related immune-responsive 438 501 8.7E-21 T 17-03-2017 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 SMART SM01060 24 411 1.2E-267 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 SUPERFAMILY SSF56634 16 523 5.63E-214 T 17-03-2017 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 Pfam PF00199 Catalase 24 408 8.8E-178 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 Gene3D G3DSA:2.40.180.10 17 379 2.2E-179 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 PIRSF PIRSF038927 1 698 0.0 T 17-03-2017 IPR024712 Catalase, mono-functional, haem-containing, clade 2 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6 SHXM_RS14610 a1d0fccbfb19020db413a6a2b1cede02 699 ProSitePatterns PS00438 Catalase proximal active site signature. 60 76 - T 17-03-2017 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS40215 ef0614e395284c78d8bcbbaa8e83eeb5 184 Gene3D G3DSA:1.20.120.450 5 146 3.5E-9 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS40215 ef0614e395284c78d8bcbbaa8e83eeb5 184 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 14 148 1.0E-21 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS40215 ef0614e395284c78d8bcbbaa8e83eeb5 184 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 12 161 1.4E-23 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS40215 ef0614e395284c78d8bcbbaa8e83eeb5 184 SUPERFAMILY SSF109854 5 153 3.66E-33 T 17-03-2017 SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 Gene3D G3DSA:3.40.50.300 1 231 3.6E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 SUPERFAMILY SSF52540 2 231 2.46E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 Gene3D G3DSA:3.40.50.300 283 507 2.3E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 Pfam PF00005 ABC transporter 304 447 1.9E-22 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 Pfam PF00005 ABC transporter 20 170 7.9E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 SUPERFAMILY SSF52540 279 507 4.32E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 SMART SM00382 313 495 8.9E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS19850 7a46379256f51be20ef478f8340cd6e7 540 SMART SM00382 28 219 1.2E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 Gene3D G3DSA:3.30.420.40 1 246 4.7E-40 T 17-03-2017 SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 258 435 7.3E-19 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 1 246 4.1E-40 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 SUPERFAMILY SSF53067 251 475 7.45E-32 T 17-03-2017 SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 Gene3D G3DSA:3.30.420.40 249 479 1.1E-25 T 17-03-2017 SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 SUPERFAMILY SSF53067 2 249 1.3E-45 T 17-03-2017 SHXM_RS41605 1ae29091acd4ac8ce655eecc5a4a3f9e 486 PIRSF PIRSF000538 1 485 8.4E-77 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS46660 0b21a3dac151fab1af44dc96ef25e12c 135 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 11 87 1.8E-8 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS46660 0b21a3dac151fab1af44dc96ef25e12c 135 Gene3D G3DSA:3.10.180.10 11 123 2.0E-16 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS46660 0b21a3dac151fab1af44dc96ef25e12c 135 SUPERFAMILY SSF54593 11 124 2.15E-20 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 SUPERFAMILY SSF51905 6 277 1.18E-72 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 SUPERFAMILY SSF51905 444 508 1.18E-72 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 SUPERFAMILY SSF54373 284 448 7.16E-42 T 17-03-2017 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 ProSitePatterns PS00624 GMC oxidoreductases signature 2. 248 262 - T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 Gene3D G3DSA:3.50.50.60 179 307 6.8E-104 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 Gene3D G3DSA:3.50.50.60 441 508 6.8E-104 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 Gene3D G3DSA:3.50.50.60 7 127 6.8E-104 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 Pfam PF00732 GMC oxidoreductase 7 290 5.9E-60 T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS25215 2fcbc06df958032cbc86387cb230de5b 528 Pfam PF05199 GMC oxidoreductase 360 500 1.2E-37 T 17-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS48580 0f9407f13f3f173c94dbd0fd11ca918a 443 Pfam PF00083 Sugar (and other) transporter 17 438 8.5E-37 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS48580 0f9407f13f3f173c94dbd0fd11ca918a 443 Gene3D G3DSA:1.20.1250.20 9 191 8.1E-21 T 17-03-2017 SHXM_RS48580 0f9407f13f3f173c94dbd0fd11ca918a 443 Gene3D G3DSA:1.20.1250.20 253 433 4.4E-23 T 17-03-2017 SHXM_RS48580 0f9407f13f3f173c94dbd0fd11ca918a 443 ProSitePatterns PS00216 Sugar transport proteins signature 1. 308 325 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS48580 0f9407f13f3f173c94dbd0fd11ca918a 443 SUPERFAMILY SSF103473 3 438 4.97E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS06045 82d3152cbeb153624dc95566496f4657 394 Pfam PF00557 Metallopeptidase family M24 159 378 2.1E-26 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS06045 82d3152cbeb153624dc95566496f4657 394 SUPERFAMILY SSF55920 151 393 1.18E-46 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS06045 82d3152cbeb153624dc95566496f4657 394 SUPERFAMILY SSF53092 4 149 3.49E-26 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS06045 82d3152cbeb153624dc95566496f4657 394 Pfam PF01321 Creatinase/Prolidase N-terminal domain 11 151 1.8E-19 T 17-03-2017 IPR000587 Creatinase, N-terminal GO:0016787 SHXM_RS06045 82d3152cbeb153624dc95566496f4657 394 Gene3D G3DSA:3.40.350.10 9 149 2.2E-31 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS06045 82d3152cbeb153624dc95566496f4657 394 Gene3D G3DSA:3.90.230.10 151 393 6.5E-42 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS13630 017d957756cfc66e0e9b4e5615c47857 339 SMART SM00421 276 333 6.2E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13630 017d957756cfc66e0e9b4e5615c47857 339 Gene3D G3DSA:1.10.10.10 271 338 7.8E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13630 017d957756cfc66e0e9b4e5615c47857 339 SUPERFAMILY SSF46894 272 338 1.53E-8 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS13630 017d957756cfc66e0e9b4e5615c47857 339 Pfam PF13384 Homeodomain-like domain 280 315 1.1E-5 T 17-03-2017 SHXM_RS16655 1972caa6db9b703112a870364b8eb346 469 Gene3D G3DSA:1.20.1250.20 18 193 1.1E-29 T 17-03-2017 SHXM_RS16655 1972caa6db9b703112a870364b8eb346 469 Pfam PF07690 Major Facilitator Superfamily 21 333 1.9E-26 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS16655 1972caa6db9b703112a870364b8eb346 469 Gene3D G3DSA:1.20.1250.20 265 459 4.2E-19 T 17-03-2017 SHXM_RS16655 1972caa6db9b703112a870364b8eb346 469 SUPERFAMILY SSF103473 250 460 8.24E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16655 1972caa6db9b703112a870364b8eb346 469 SUPERFAMILY SSF103473 15 202 8.24E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.366.10 564 691 1.4E-67 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.366.10 760 878 1.4E-67 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00826 2488 2652 5.7E-88 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF52151 2308 2404 3.14E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF52151 2119 2247 3.14E-72 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF51735 2769 2952 1.44E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.366.10 2115 2241 2.7E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.366.10 2306 2425 2.7E-79 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3283 3298 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.47.10 1859 2024 6.8E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.47.10 298 464 1.2E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF08659 KR domain 1219 1397 4.8E-64 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF08659 KR domain 2964 3142 2.5E-55 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.30.70.250 695 759 2.3E-9 T 17-03-2017 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.30.70.250 2245 2304 8.2E-7 T 17-03-2017 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 198 214 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF53901 31 406 3.72E-100 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:1.10.1200.10 1502 1572 2.7E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:1.10.1200.10 3255 3329 3.8E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1528 1543 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00825 Beta-ketoacyl synthase 1598 2024 4.2E-222 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00825 Beta-ketoacyl synthase 37 463 6.4E-205 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF00550 Phosphopantetheine attachment site 1504 1569 3.5E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF00550 Phosphopantetheine attachment site 3258 3324 4.6E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 416 532 2.1E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1976 2091 2.0E-15 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF53901 1593 1968 3.63E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2964 3144 4.7E-61 T 17-03-2017 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1219 1399 8.8E-64 T 17-03-2017 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.47.10 32 297 1.4E-84 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.47.10 1593 1858 6.6E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF55048 695 760 8.63E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00823 Phosphopantetheine attachment site 1501 1573 5.6E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00823 Phosphopantetheine attachment site 3256 3328 5.7E-27 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF52151 570 696 6.54E-62 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF52151 761 854 6.54E-62 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF47336 1496 1611 4.58E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1854 1971 2.4E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 8.8E-41 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 573 865 1.7E-110 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 2123 2421 7.1E-125 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF51735 974 1205 3.19E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF51735 2958 3210 3.9E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF14765 Polyketide synthase dehydratase 2488 2758 4.2E-57 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF47336 3249 3335 7.72E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM01294 1506 1569 2.1E-6 T 17-03-2017 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SMART SM01294 3257 3324 1.9E-4 T 17-03-2017 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF55048 2246 2303 1.28E-9 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 3.1E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1596 1846 1.4E-91 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF00698 Acyl transferase domain 2122 2438 3.5E-55 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Pfam PF00698 Acyl transferase domain 571 884 7.9E-85 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1759 1775 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.50.720 1486 1501 4.1E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.50.720 1219 1401 4.1E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 Gene3D G3DSA:3.40.50.720 2964 3174 1.8E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07225 dfea5d95e1de7b6c270f66e3c7403a87 3408 SUPERFAMILY SSF51735 1215 1442 7.5E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25520 7ef41973e5f1814e604d685dc2924e46 465 SUPERFAMILY SSF48452 351 427 1.46E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25520 7ef41973e5f1814e604d685dc2924e46 465 SUPERFAMILY SSF48452 225 255 1.46E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25520 7ef41973e5f1814e604d685dc2924e46 465 Gene3D G3DSA:1.25.40.10 352 433 2.3E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25520 7ef41973e5f1814e604d685dc2924e46 465 Gene3D G3DSA:1.25.40.10 226 255 2.3E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS45455 61c8e375fe33dff3956fd64069d8e066 479 PIRSF PIRSF006060 3 476 4.4E-52 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS45455 61c8e375fe33dff3956fd64069d8e066 479 Pfam PF13520 Amino acid permease 28 450 1.5E-26 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS40980 2c8027a1ea2192b04e0eadb1d75bc3a3 318 SUPERFAMILY SSF161098 77 303 6.67E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40980 2c8027a1ea2192b04e0eadb1d75bc3a3 318 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 108 305 3.3E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40980 2c8027a1ea2192b04e0eadb1d75bc3a3 318 Gene3D G3DSA:1.10.3720.10 30 306 1.9E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 Gene3D G3DSA:3.90.110.10 156 326 5.0E-75 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 PIRSF PIRSF000102 2 326 2.1E-58 T 17-03-2017 IPR001557 L-lactate/malate dehydrogenase GO:0016616|GO:0019752|GO:0055114 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 Gene3D G3DSA:3.40.50.720 5 154 2.1E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 Hamap MF_01517 Malate dehydrogenase [mdh]. 2 327 56.96 T 17-03-2017 IPR010945 Malate dehydrogenase, type 2 GO:0006108|GO:0016615|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 TIGRFAM TIGR01759 MalateDH-SF1: malate dehydrogenase 4 323 7.0E-144 T 17-03-2017 IPR010945 Malate dehydrogenase, type 2 GO:0006108|GO:0016615|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 Pfam PF00056 lactate/malate dehydrogenase, NAD binding domain 7 147 1.2E-30 T 17-03-2017 IPR001236 Lactate/malate dehydrogenase, N-terminal GO:0016491|GO:0055114 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 Pfam PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain 157 322 7.7E-33 T 17-03-2017 IPR022383 Lactate/malate dehydrogenase, C-terminal GO:0016616|GO:0055114 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 SUPERFAMILY SSF51735 5 156 3.63E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 ProSitePatterns PS00068 Malate dehydrogenase active site signature. 156 168 - T 17-03-2017 IPR001252 Malate dehydrogenase, active site GO:0006108|GO:0016615|GO:0055114 KEGG: 00020+1.1.1.37|KEGG: 00270+1.1.1.37|KEGG: 00620+1.1.1.37|KEGG: 00630+1.1.1.37|KEGG: 00680+1.1.1.37|KEGG: 00710+1.1.1.37|KEGG: 00720+1.1.1.37|MetaCyc: PWY-1622|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7115|MetaCyc: PWY-7383|Reactome: R-HSA-70263 SHXM_RS25245 dacc1202bc3232e17efc9f5c603217e8 329 SUPERFAMILY SSF56327 157 324 3.4E-59 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS33165 1d2c9e2c316aaa313199d50d433e32ce 219 Pfam PF01625 Peptide methionine sulfoxide reductase 50 201 1.2E-65 T 17-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS33165 1d2c9e2c316aaa313199d50d433e32ce 219 TIGRFAM TIGR00401 msrA: peptide-methionine (S)-S-oxide reductase 49 201 5.2E-65 T 17-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS33165 1d2c9e2c316aaa313199d50d433e32ce 219 Hamap MF_01401 Peptide methionine sulfoxide reductase MsrA [msrA]. 46 207 37.062 T 17-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS33165 1d2c9e2c316aaa313199d50d433e32ce 219 Gene3D G3DSA:3.30.1060.10 25 201 4.7E-77 T 17-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS33165 1d2c9e2c316aaa313199d50d433e32ce 219 SUPERFAMILY SSF55068 26 211 6.15E-78 T 17-03-2017 IPR002569 Peptide methionine sulphoxide reductase MsrA GO:0008113|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS12860 379a5c1d71256cd006a8bab0b2cbca47 275 Gene3D G3DSA:3.40.50.1820 12 273 1.2E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS12860 379a5c1d71256cd006a8bab0b2cbca47 275 Pfam PF12697 Alpha/beta hydrolase family 35 267 1.1E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS12860 379a5c1d71256cd006a8bab0b2cbca47 275 SUPERFAMILY SSF53474 14 273 2.23E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09545 c964798f12d17bf4cd8db5ead0d50977 273 Pfam PF13359 DDE superfamily endonuclease 108 167 1.5E-8 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 Gene3D G3DSA:1.10.10.10 870 930 2.7E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 SUPERFAMILY SSF46894 868 932 1.09E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 906 918 3.1E-6 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 890 906 3.1E-6 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 876 890 3.1E-6 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 Pfam PF13191 AAA ATPase domain 2 165 2.5E-21 T 17-03-2017 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 SMART SM00421 873 930 5.1E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 SUPERFAMILY SSF52540 133 252 3.37E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 SUPERFAMILY SSF52540 5 80 3.37E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 Pfam PF00196 Bacterial regulatory proteins, luxR family 875 929 1.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 Gene3D G3DSA:3.40.50.300 112 151 7.8E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44895 2ada4a24587ae978d8880e36c9088b80 935 Gene3D G3DSA:3.40.50.300 5 62 7.8E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 Gene3D G3DSA:3.20.20.40 68 356 2.9E-95 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PIRSF PIRSF001100 12 359 4.9E-96 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 Pfam PF01341 Glycosyl hydrolases family 6 77 338 5.6E-82 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 245 255 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 157 172 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 214 227 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 129 142 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 275 288 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 295 315 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 319 333 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 PRINTS PR00733 Glycosyl hydrolase family 6 signature 89 108 8.4E-38 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS23255 cb2e9856f72c93303a1438551e81c685 361 SUPERFAMILY SSF51989 60 357 1.15E-86 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 Pfam PF00106 short chain dehydrogenase 10 192 9.5E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 Gene3D G3DSA:3.40.50.720 2 255 3.8E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 149 168 7.6E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 7.6E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 129 137 7.6E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 1.1E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 170 187 1.1E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 1.1E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 219 239 1.1E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.1E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 168 1.1E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS22490 ac46702522c9894e746e974faba1acb8 260 SUPERFAMILY SSF51735 1 255 8.69E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 SUPERFAMILY SSF48452 100 264 2.32E-34 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 SUPERFAMILY SSF46894 7 97 5.1E-10 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 Pfam PF03704 Bacterial transcriptional activator domain 104 245 1.7E-40 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 Gene3D G3DSA:1.10.10.10 17 100 1.1E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 Gene3D G3DSA:1.25.40.10 635 636 2.6E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 Gene3D G3DSA:1.25.40.10 165 225 2.6E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 Gene3D G3DSA:1.25.40.10 687 710 2.6E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 SMART SM00862 18 97 5.6E-7 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 SMART SM01043 104 245 8.0E-52 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS31470 66df2f5f8addaa1dac9cbd293cd0162d 846 Pfam PF00486 Transcriptional regulatory protein, C terminal 25 97 9.9E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 Gene3D G3DSA:3.40.50.720 145 249 2.9E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 Pfam PF13602 Zinc-binding dehydrogenase 195 299 5.0E-15 T 17-03-2017 SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 Gene3D G3DSA:3.90.180.10 1 144 2.2E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 SUPERFAMILY SSF50129 1 117 1.07E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 SUPERFAMILY SSF50129 271 299 1.07E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 88 1.0E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 SMART SM00829 10 299 7.3E-14 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS38700 ea6e90c5915c8bb179ead96f2d4a14df 301 SUPERFAMILY SSF51735 114 239 1.29E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05250 f6ab00bb3e1f0b7797ac3ab58ef1c593 304 Pfam PF00892 EamA-like transporter family 167 297 1.1E-14 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS05250 f6ab00bb3e1f0b7797ac3ab58ef1c593 304 SUPERFAMILY SSF103481 210 301 1.83E-8 T 17-03-2017 SHXM_RS05250 f6ab00bb3e1f0b7797ac3ab58ef1c593 304 SUPERFAMILY SSF103481 68 158 2.09E-5 T 17-03-2017 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 SUPERFAMILY SSF53756 4 732 4.03E-197 T 17-03-2017 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 Gene3D G3DSA:3.40.50.2000 440 705 2.2E-83 T 17-03-2017 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 Pfam PF00343 Carbohydrate phosphorylase 128 173 5.3E-6 T 17-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 Pfam PF00343 Carbohydrate phosphorylase 273 612 2.7E-15 T 17-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 TIGRFAM TIGR02094 more_P_ylases: alpha-glucan phosphorylases 110 702 1.9E-227 T 17-03-2017 IPR011834 Alpha-glucan phosphorylase GO:0004645|GO:0005975|GO:0030170 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 Pfam PF11897 Protein of unknown function (DUF3417) 13 123 6.3E-35 T 17-03-2017 IPR024517 Glycogen phosphorylase, domain of unknown function DUF3417 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 ProSitePatterns PS00102 Phosphorylase pyridoxal-phosphate attachment site. 590 602 - T 17-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 PIRSF PIRSF000460 1 789 2.7E-249 T 17-03-2017 IPR000811 Glycosyl transferase, family 35 GO:0005975|GO:0008184 KEGG: 00500+2.4.1.1|MetaCyc: PWY-5941|MetaCyc: PWY-6731|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 SHXM_RS35735 e7c48850eedf53b00f6927b94ea02968 859 Gene3D G3DSA:3.40.50.2000 24 437 8.3E-90 T 17-03-2017 SHXM_RS26455 6d995c4e5279936381728ad149eddcd3 179 Gene3D G3DSA:3.40.50.2020 3 177 5.9E-81 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS26455 6d995c4e5279936381728ad149eddcd3 179 Pfam PF00156 Phosphoribosyl transferase domain 14 159 8.2E-26 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS26455 6d995c4e5279936381728ad149eddcd3 179 SUPERFAMILY SSF53271 4 177 8.39E-56 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS26455 6d995c4e5279936381728ad149eddcd3 179 TIGRFAM TIGR01203 HGPRTase: hypoxanthine phosphoribosyltransferase 8 172 2.0E-66 T 17-03-2017 IPR005904 Hypoxanthine phosphoribosyl transferase GO:0004422|GO:0005737|GO:0006166 KEGG: 00230+2.4.2.8|KEGG: 00983+2.4.2.8|MetaCyc: PWY-6599|MetaCyc: PWY-6609|MetaCyc: PWY-6610|MetaCyc: PWY-6620 SHXM_RS16595 5ed4641bfb05c45aca00e3ab7414f6cd 258 Gene3D G3DSA:3.75.10.10 3 253 1.1E-70 T 17-03-2017 SHXM_RS16595 5ed4641bfb05c45aca00e3ab7414f6cd 258 SUPERFAMILY SSF55909 4 254 1.22E-56 T 17-03-2017 SHXM_RS16595 5ed4641bfb05c45aca00e3ab7414f6cd 258 Pfam PF02274 Amidinotransferase 32 251 3.2E-12 T 17-03-2017 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 SUPERFAMILY SSF48208 329 963 7.94E-296 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Gene3D G3DSA:4.10.870.10 877 940 3.5E-31 T 17-03-2017 IPR027390 Endoglucanase F, domain 3 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Gene3D G3DSA:2.60.40.290 33 135 2.3E-34 T 17-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Gene3D G3DSA:1.50.10.10 461 476 9.7E-208 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Gene3D G3DSA:1.50.10.10 556 874 9.7E-208 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Gene3D G3DSA:1.50.10.10 941 963 9.7E-208 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Gene3D G3DSA:1.50.10.10 329 415 9.7E-208 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 SMART SM00637 34 133 8.7E-45 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 692 715 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 549 576 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 383 400 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 895 923 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 504 528 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 738 764 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 357 382 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 622 641 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 PRINTS PR00844 Glycosyl hydrolase family 48 signature 793 813 5.4E-109 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 SUPERFAMILY SSF49384 33 134 5.72E-30 T 17-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Pfam PF02011 Glycosyl hydrolase family 48 334 962 0.0 T 17-03-2017 IPR000556 Glycoside hydrolase, 48F GO:0004553|GO:0008810|GO:0030245 SHXM_RS22750 b02e1f4b2f98fce1df9ff5346f89e71d 963 Pfam PF00553 Cellulose binding domain 36 133 4.3E-26 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS08740 43cde8edd4bc3ada846ac9a76fe7339c 76 SUPERFAMILY SSF51735 17 75 5.83E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08740 43cde8edd4bc3ada846ac9a76fe7339c 76 Gene3D G3DSA:3.40.50.720 17 75 6.3E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08740 43cde8edd4bc3ada846ac9a76fe7339c 76 Pfam PF13380 CoA binding domain 18 75 3.6E-15 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS31765 7c03fd0349f78abafce538604eea4471 160 TIGRFAM TIGR00026 hi_GC_TIGR00026: deazaflavin-dependent oxidoreductase, nitroreductase family 44 154 3.7E-27 T 17-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 SHXM_RS31765 7c03fd0349f78abafce538604eea4471 160 Pfam PF04075 Domain of unknown function (DUF385) 35 151 3.5E-25 T 17-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 Gene3D G3DSA:3.50.50.60 5 110 8.4E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 295 5.4E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 SUPERFAMILY SSF51905 5 306 1.84E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 ProSitePatterns PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 136 156 - T 17-03-2017 IPR008255 Pyridine nucleotide-disulphide oxidoreductase, class-II, active site GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 6.6E-37 T 17-03-2017 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 148 166 6.6E-37 T 17-03-2017 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 232 248 6.6E-37 T 17-03-2017 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 106 124 6.6E-37 T 17-03-2017 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 259 281 6.6E-37 T 17-03-2017 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 Gene3D G3DSA:3.50.50.60 111 300 1.3E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 TIGRFAM TIGR01292 TRX_reduct: thioredoxin-disulfide reductase 6 306 8.9E-121 T 17-03-2017 IPR005982 Thioredoxin reductase GO:0004791|GO:0005737|GO:0019430|GO:0055114 KEGG: 00240+1.8.1.9|KEGG: 00450+1.8.1.9 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 40 55 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 196 212 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 269 287 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 107 115 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 234 255 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 61 71 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 144 168 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 129 141 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS28065 8c442abbba97449b213afbed77d12c2a 316 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 6 28 1.1E-80 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS42155 8013ca9f7fc87f6a4afe2646f9c3a400 303 SMART SM00849 37 219 0.0082 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS42155 8013ca9f7fc87f6a4afe2646f9c3a400 303 Gene3D G3DSA:3.60.15.10 26 293 3.1E-61 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS42155 8013ca9f7fc87f6a4afe2646f9c3a400 303 Pfam PF12706 Beta-lactamase superfamily domain 49 251 2.6E-27 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS42155 8013ca9f7fc87f6a4afe2646f9c3a400 303 SUPERFAMILY SSF56281 139 272 2.36E-25 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS42155 8013ca9f7fc87f6a4afe2646f9c3a400 303 SUPERFAMILY SSF56281 31 111 2.36E-25 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 SUPERFAMILY SSF46785 3 110 3.35E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 SUPERFAMILY SSF53850 89 298 1.63E-31 T 17-03-2017 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 3.3E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 19 30 1.7E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 40 51 1.7E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 30 40 1.7E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 Pfam PF03466 LysR substrate binding domain 88 295 9.9E-29 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 Gene3D G3DSA:3.40.190.10 90 162 9.6E-7 T 17-03-2017 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 Gene3D G3DSA:3.40.190.10 270 297 9.6E-7 T 17-03-2017 SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 Gene3D G3DSA:1.10.10.10 2 82 2.4E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00925 a00873fe73932124a0d098e9c508324f 301 Gene3D G3DSA:3.40.190.10 163 259 6.1E-15 T 17-03-2017 SHXM_RS50460 c7b45881314eaeeb0440fb335f8a033a 653 Pfam PF10022 Uncharacterized protein conserved in bacteria (DUF2264) 16 365 3.3E-106 T 17-03-2017 IPR016624 Uncharacterised conserved protein UCP014753 SHXM_RS03630 2b5a6187736ecb24ff82fc315f7a72a3 235 Pfam PF01738 Dienelactone hydrolase family 27 232 6.3E-54 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS03630 2b5a6187736ecb24ff82fc315f7a72a3 235 Gene3D G3DSA:3.40.50.1820 13 232 5.2E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS03630 2b5a6187736ecb24ff82fc315f7a72a3 235 SUPERFAMILY SSF53474 14 234 2.8E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45820 3c21781cc8a8f6dffda062e40738a690 158 Gene3D G3DSA:3.10.129.10 24 149 1.3E-10 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45820 3c21781cc8a8f6dffda062e40738a690 158 Pfam PF13452 N-terminal half of MaoC dehydratase 14 149 9.6E-10 T 17-03-2017 SHXM_RS45820 3c21781cc8a8f6dffda062e40738a690 158 SUPERFAMILY SSF54637 19 154 5.46E-13 T 17-03-2017 IPR029069 HotDog domain SHXM_RS41110 c9b0530234eb63b59c946c3180b28573 203 Gene3D G3DSA:3.40.50.360 3 201 1.4E-59 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS41110 c9b0530234eb63b59c946c3180b28573 203 Pfam PF03358 NADPH-dependent FMN reductase 13 145 5.1E-14 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS41110 c9b0530234eb63b59c946c3180b28573 203 SUPERFAMILY SSF52218 6 199 4.85E-45 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS41110 c9b0530234eb63b59c946c3180b28573 203 TIGRFAM TIGR01755 flav_wrbA: NAD(P)H:quinone oxidoreductase, type IV 5 197 8.3E-41 T 17-03-2017 IPR010089 Flavoprotein WrbA GO:0010181|GO:0045892 KEGG: 00130+1.6.5.2|MetaCyc: PWY-7731 SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 SMART SM00331 439 659 1.4E-47 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 Gene3D G3DSA:3.30.450.40 239 416 5.3E-30 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 Pfam PF13185 GAF domain 293 408 6.1E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 Pfam PF13581 Histidine kinase-like ATPase domain 672 781 8.8E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 468 659 6.7E-53 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 SMART SM00065 249 418 4.1E-4 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 SUPERFAMILY SSF55781 303 421 1.33E-15 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 SUPERFAMILY SSF55785 19 96 3.84E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 Gene3D G3DSA:3.30.450.20 19 90 4.6E-6 T 17-03-2017 SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 SUPERFAMILY SSF55874 699 779 9.03E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00325 85ed3b536143e5a686c7943a077fca90 793 SUPERFAMILY SSF81606 455 657 1.12E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS20295 3f2fc5ee4443485638dd84a225960cac 222 Pfam PF02678 Pirin 16 118 8.8E-31 T 17-03-2017 IPR003829 Pirin, N-terminal domain SHXM_RS20295 3f2fc5ee4443485638dd84a225960cac 222 Gene3D G3DSA:2.60.120.10 17 219 1.0E-47 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS20295 3f2fc5ee4443485638dd84a225960cac 222 SUPERFAMILY SSF51182 3 215 4.69E-52 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 60 88 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 Pfam PF00106 short chain dehydrogenase 4 112 5.1E-16 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 Gene3D G3DSA:3.40.50.720 4 151 2.2E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 37 53 1.0E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 94 111 1.0E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 73 92 1.0E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01235 e88248f12d6daf555abb8efbbfe86b48 151 SUPERFAMILY SSF51735 6 151 4.56E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22555 c77a39eaaa16477ce932832d91ab0083 209 SUPERFAMILY SSF55961 20 163 1.31E-32 T 17-03-2017 SHXM_RS22555 c77a39eaaa16477ce932832d91ab0083 209 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 35 141 4.0E-12 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS22555 c77a39eaaa16477ce932832d91ab0083 209 Gene3D G3DSA:3.30.530.20 23 158 1.3E-33 T 17-03-2017 IPR023393 START-like domain SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 PIRSF PIRSF005739 2 340 1.6E-14 T 17-03-2017 IPR016461 O-methyltransferase COMT-type GO:0008168 SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 SUPERFAMILY SSF53335 107 334 5.83E-37 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 SUPERFAMILY SSF46785 12 91 8.84E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 Pfam PF16864 Dimerisation domain 17 86 1.5E-6 T 17-03-2017 IPR031725 Acetylserotonin O-methyltransferase, dimerisation domain SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 Gene3D G3DSA:1.10.10.10 12 85 2.2E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 Gene3D G3DSA:3.40.50.150 107 340 2.3E-39 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14850 b73ebb0ad0634d4a15874400ddf4f10d 345 Pfam PF00891 O-methyltransferase 137 326 2.4E-27 T 17-03-2017 IPR001077 O-methyltransferase, family 2 GO:0008171 SHXM_RS16395 7c5cc906e3d71be11178f377d0e9abce 947 Gene3D G3DSA:1.10.439.10 130 292 3.3E-40 T 17-03-2017 IPR023343 Penicillin amidase type, domain1 GO:0016811 SHXM_RS16395 7c5cc906e3d71be11178f377d0e9abce 947 SUPERFAMILY SSF56235 132 337 2.42E-99 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS16395 7c5cc906e3d71be11178f377d0e9abce 947 SUPERFAMILY SSF56235 407 819 2.42E-99 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS16395 7c5cc906e3d71be11178f377d0e9abce 947 Pfam PF01804 Penicillin amidase 133 934 2.7E-123 T 17-03-2017 IPR002692 Penicillin/cephalosporin acylase GO:0016787|GO:0017000 SHXM_RS16395 7c5cc906e3d71be11178f377d0e9abce 947 Gene3D G3DSA:3.60.20.10 587 827 5.1E-63 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS16395 7c5cc906e3d71be11178f377d0e9abce 947 Gene3D G3DSA:3.60.20.10 415 494 5.1E-63 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 SUPERFAMILY SSF54292 9 94 1.57E-27 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 Gene3D G3DSA:3.10.20.30 8 80 2.8E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 12 59 6.1E-8 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 Gene3D G3DSA:1.10.150.120 81 178 4.9E-32 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 SUPERFAMILY SSF47741 90 176 5.89E-28 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 Pfam PF01799 [2Fe-2S] binding domain 79 169 2.2E-29 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS45490 060e6ea5ca22e8f8846a90433fb91e58 185 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 45 53 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Gene3D G3DSA:3.40.50.300 30 216 6.8E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 SMART SM00487 32 214 2.9E-31 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Pfam PF13234 rRNA-processing arch domain 502 602 1.9E-4 T 17-03-2017 IPR025696 rRNA-processing arch domain SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 SMART SM00490 354 446 4.8E-12 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Pfam PF08148 DSHCT (NUC185) domain 766 934 1.4E-35 T 17-03-2017 IPR012961 ATP-dependent RNA helicase Ski2, C-terminal SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 SMART SM01142 763 939 8.5E-63 T 17-03-2017 IPR012961 ATP-dependent RNA helicase Ski2, C-terminal SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 SUPERFAMILY SSF52540 46 187 8.91E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 SUPERFAMILY SSF52540 366 458 8.91E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 SUPERFAMILY SSF52540 272 324 8.91E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Gene3D G3DSA:3.40.50.300 294 327 5.7E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Gene3D G3DSA:3.40.50.300 369 456 5.7E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Pfam PF00270 DEAD/DEAH box helicase 38 186 1.4E-18 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS15850 2bf0ba7f2c1aaafade3f8f11ead9aa60 940 Pfam PF00271 Helicase conserved C-terminal domain 367 446 1.2E-4 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS26740 91c4410d37fff486672432d50204d610 157 Gene3D G3DSA:3.90.79.10 6 147 4.1E-34 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS26740 91c4410d37fff486672432d50204d610 157 ProSitePatterns PS00893 Nudix box signature. 49 70 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS26740 91c4410d37fff486672432d50204d610 157 Pfam PF00293 NUDIX domain 20 136 4.0E-19 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS26740 91c4410d37fff486672432d50204d610 157 PRINTS PR00502 NUDIX hydrolase family signature 58 73 3.2E-6 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS26740 91c4410d37fff486672432d50204d610 157 PRINTS PR00502 NUDIX hydrolase family signature 44 58 3.2E-6 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS26740 91c4410d37fff486672432d50204d610 157 SUPERFAMILY SSF55811 9 148 3.25E-34 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS19390 a0328170025d6d5b43f533f6d85dc9e7 286 Gene3D G3DSA:3.20.20.60 22 286 4.3E-113 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS19390 a0328170025d6d5b43f533f6d85dc9e7 286 SUPERFAMILY SSF51621 23 285 7.46E-102 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS19390 a0328170025d6d5b43f533f6d85dc9e7 286 Pfam PF02548 Ketopantoate hydroxymethyltransferase 23 280 1.2E-108 T 17-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 SHXM_RS19390 a0328170025d6d5b43f533f6d85dc9e7 286 TIGRFAM TIGR00222 panB: 3-methyl-2-oxobutanoate hydroxymethyltransferase 28 286 3.1E-95 T 17-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 SHXM_RS19390 a0328170025d6d5b43f533f6d85dc9e7 286 PIRSF PIRSF000388 17 286 1.6E-109 T 17-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 SHXM_RS19390 a0328170025d6d5b43f533f6d85dc9e7 286 Hamap MF_00156 3-methyl-2-oxobutanoate hydroxymethyltransferase [panB]. 24 285 42.539 T 17-03-2017 IPR003700 Ketopantoate hydroxymethyltransferase GO:0003864|GO:0015940 KEGG: 00770+2.1.2.11|MetaCyc: PWY-6654 SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 Pfam PF00072 Response regulator receiver domain 22 130 3.8E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 SUPERFAMILY SSF46894 147 242 5.39E-27 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 Gene3D G3DSA:1.10.10.10 148 243 7.2E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 SMART SM00862 170 241 1.7E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 SUPERFAMILY SSF52172 14 139 1.01E-41 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 Gene3D G3DSA:3.40.50.2300 16 138 6.3E-40 T 17-03-2017 SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 SMART SM00448 20 130 4.8E-42 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS34855 1106d8e5575372ccc3274630013edaee 246 Pfam PF00486 Transcriptional regulatory protein, C terminal 170 241 1.1E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS07205 8594fae36d59181780c0c6bd96eb0666 198 SUPERFAMILY SSF51182 1 194 3.36E-65 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS07205 8594fae36d59181780c0c6bd96eb0666 198 Gene3D G3DSA:2.60.120.10 1 190 2.2E-64 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS07205 8594fae36d59181780c0c6bd96eb0666 198 ProDom PD001462 35-EPIMERASE DTDP-4-DEHYDRORHAMNOSE ISOMERASE RMLC EPIMERASE RELATED DTDP-6-DEOXY-D-GLUCOSE-35-EPIMERASE DTDP-4-KETO-6-DEOXY-D-GLUCOSE DTDP-4-KETO-6-DEOXYGLUCOSE-35-EPIMERASE DTDP-L-RHAMNOSE 1 178 1.0E-61 T 17-03-2017 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 SHXM_RS07205 8594fae36d59181780c0c6bd96eb0666 198 Pfam PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase 6 177 2.4E-54 T 17-03-2017 IPR000888 dTDP-4-dehydrorhamnose 3,5-epimerase-related GO:0008830 SHXM_RS41875 f3079723dcf1b175dd7fbd87822851ad 304 SUPERFAMILY SSF54593 2 269 4.17E-37 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS41875 f3079723dcf1b175dd7fbd87822851ad 304 Gene3D G3DSA:3.10.180.10 153 295 3.2E-37 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS41875 f3079723dcf1b175dd7fbd87822851ad 304 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 153 264 1.3E-13 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS41875 f3079723dcf1b175dd7fbd87822851ad 304 Gene3D G3DSA:3.10.180.10 2 109 2.9E-13 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS34345 3bce2203c32260c1ce03835f4914e632 252 Pfam PF01987 Mitochondrial biogenesis AIM24 21 215 2.1E-31 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS34345 3bce2203c32260c1ce03835f4914e632 252 SUPERFAMILY SSF51219 19 226 5.23E-45 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS34345 3bce2203c32260c1ce03835f4914e632 252 Gene3D G3DSA:3.60.160.10 20 225 2.9E-37 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS27050 334f1605c8ebac21abb95d50f65633bd 312 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 51 242 3.4E-6 T 17-03-2017 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 SHXM_RS27050 334f1605c8ebac21abb95d50f65633bd 312 Gene3D G3DSA:3.60.21.10 49 119 1.8E-11 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS27050 334f1605c8ebac21abb95d50f65633bd 312 Gene3D G3DSA:3.60.21.10 152 257 1.8E-11 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS27050 334f1605c8ebac21abb95d50f65633bd 312 SUPERFAMILY SSF56300 44 306 2.53E-25 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 Gene3D G3DSA:1.20.140.10 217 396 1.9E-54 T 17-03-2017 SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 242 373 1.7E-17 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 SUPERFAMILY SSF56645 20 224 1.57E-52 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 Gene3D G3DSA:1.10.540.10 7 115 5.0E-29 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 134 215 1.9E-14 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 SUPERFAMILY SSF47203 237 396 1.61E-23 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 19 120 1.4E-12 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 TIGRFAM TIGR04022 sulfur_SfnB: sulfur acquisition oxidoreductase, SfnB family 8 398 9.3E-171 T 17-03-2017 IPR023922 Sulphate-starvation-induced SfnB SHXM_RS13670 3b11fb236a6cb847d86bb792b274b453 399 Gene3D G3DSA:2.40.110.10 137 216 2.5E-23 T 17-03-2017 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 SUPERFAMILY SSF53474 4 283 2.4E-68 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 PRINTS PR00412 Epoxide hydrolase signature 33 51 1.4E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 PRINTS PR00412 Epoxide hydrolase signature 113 126 1.4E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 PRINTS PR00412 Epoxide hydrolase signature 259 281 1.4E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 Pfam PF00561 alpha/beta hydrolase fold 27 269 2.2E-28 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 PRINTS PR00111 Alpha/beta hydrolase fold signature 52 67 2.0E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 PRINTS PR00111 Alpha/beta hydrolase fold signature 113 126 2.0E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01265 235ae0cc24113518bd5db2f6dbc8315d 284 Gene3D G3DSA:3.40.50.1820 4 283 4.9E-62 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45215 5918e03b7498cebeeccad60722d4ebee 241 Gene3D G3DSA:2.60.40.1120 144 193 4.1E-4 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS45215 5918e03b7498cebeeccad60722d4ebee 241 SUPERFAMILY SSF49464 144 193 4.97E-5 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS11315 a1d6fcf4dc005c6d6ab4a01eb5508d3b 66 Pfam PF04149 Domain of unknown function (DUF397) 10 64 2.9E-21 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS32520 b5e4096cf40036c72ced0d12ef1e6334 246 SMART SM00422 12 80 6.4E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS32520 b5e4096cf40036c72ced0d12ef1e6334 246 Pfam PF13411 MerR HTH family regulatory protein 12 78 2.8E-19 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS32520 b5e4096cf40036c72ced0d12ef1e6334 246 Gene3D G3DSA:1.10.1660.10 12 91 1.7E-18 T 17-03-2017 SHXM_RS32520 b5e4096cf40036c72ced0d12ef1e6334 246 SUPERFAMILY SSF46955 12 91 4.21E-18 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 Gene3D G3DSA:1.10.443.10 178 230 1.9E-30 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 Gene3D G3DSA:1.10.443.10 300 420 1.9E-30 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 Pfam PF00589 Phage integrase family 327 415 5.9E-13 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 Gene3D G3DSA:1.10.150.130 71 171 1.4E-16 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 Pfam PF14659 Phage integrase, N-terminal SAM-like domain 71 127 5.7E-5 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 SUPERFAMILY SSF56349 300 424 1.38E-50 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS26835 32a1c66af65c08c7442c5d39b8b65e67 460 SUPERFAMILY SSF56349 70 230 1.38E-50 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS20435 d72481bb31be57671ac34a5f9d2b3021 510 SUPERFAMILY SSF51011 380 509 5.4E-38 T 17-03-2017 SHXM_RS20435 d72481bb31be57671ac34a5f9d2b3021 510 Pfam PF06964 Alpha-L-arabinofuranosidase C-terminal domain 302 503 9.5E-43 T 17-03-2017 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55 SHXM_RS20435 d72481bb31be57671ac34a5f9d2b3021 510 SMART SM00813 302 503 1.5E-82 T 17-03-2017 IPR010720 Alpha-L-arabinofuranosidase, C-terminal GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55 SHXM_RS20435 d72481bb31be57671ac34a5f9d2b3021 510 Gene3D G3DSA:3.20.20.80 51 365 1.3E-35 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS20435 d72481bb31be57671ac34a5f9d2b3021 510 SUPERFAMILY SSF51445 28 392 2.61E-108 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS00720 553179ccb950aa9420a50595047a178f 658 Pfam PF13556 PucR C-terminal helix-turn-helix domain 583 641 1.6E-16 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS00720 553179ccb950aa9420a50595047a178f 658 SUPERFAMILY SSF55781 75 261 4.36E-26 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00720 553179ccb950aa9420a50595047a178f 658 Pfam PF13185 GAF domain 92 234 2.9E-15 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS00720 553179ccb950aa9420a50595047a178f 658 Gene3D G3DSA:3.30.450.40 70 248 1.6E-29 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00720 553179ccb950aa9420a50595047a178f 658 SMART SM00065 92 243 2.8E-19 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS48875 6be1ec2511dc3ba93965940a6ad17128 393 Pfam PF00296 Luciferase-like monooxygenase 2 319 2.6E-43 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48875 6be1ec2511dc3ba93965940a6ad17128 393 SUPERFAMILY SSF51679 1 349 1.7E-68 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48875 6be1ec2511dc3ba93965940a6ad17128 393 Gene3D G3DSA:3.20.20.30 1 349 5.0E-75 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48910 6be1ec2511dc3ba93965940a6ad17128 393 Pfam PF00296 Luciferase-like monooxygenase 2 319 2.6E-43 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48910 6be1ec2511dc3ba93965940a6ad17128 393 SUPERFAMILY SSF51679 1 349 1.7E-68 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48910 6be1ec2511dc3ba93965940a6ad17128 393 Gene3D G3DSA:3.20.20.30 1 349 5.0E-75 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS15010 b810bf13ba5639a96b3647210349b65e 320 Pfam PF02678 Pirin 45 140 6.2E-24 T 17-03-2017 IPR003829 Pirin, N-terminal domain SHXM_RS15010 b810bf13ba5639a96b3647210349b65e 320 SUPERFAMILY SSF51182 29 302 1.37E-66 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS15010 b810bf13ba5639a96b3647210349b65e 320 PIRSF PIRSF006232 20 300 8.4E-76 T 17-03-2017 IPR012093 Pirin SHXM_RS15010 b810bf13ba5639a96b3647210349b65e 320 Gene3D G3DSA:2.60.120.10 32 265 1.4E-58 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS15010 b810bf13ba5639a96b3647210349b65e 320 Pfam PF05726 Pirin C-terminal cupin domain 192 291 3.2E-18 T 17-03-2017 IPR008778 Pirin, C-terminal domain SHXM_RS30085 81733ae5dc1f47f6906c8725af72d4d6 95 Pfam PF07210 Protein of unknown function (DUF1416) 2 95 9.3E-36 T 17-03-2017 IPR010814 Protein of unknown function DUF1416 SHXM_RS30085 81733ae5dc1f47f6906c8725af72d4d6 95 Gene3D G3DSA:2.60.40.10 19 84 1.1E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS25715 b225f6ce00ce75e0eeb0a82cff341530 490 SUPERFAMILY SSF103473 90 471 5.62E-18 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS25715 b225f6ce00ce75e0eeb0a82cff341530 490 ProSitePatterns PS00099 Thiolases active site. 342 355 - T 17-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SHXM_RS25715 b225f6ce00ce75e0eeb0a82cff341530 490 Pfam PF07690 Major Facilitator Superfamily 88 443 2.2E-12 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS25715 b225f6ce00ce75e0eeb0a82cff341530 490 Gene3D G3DSA:1.20.1250.20 92 237 6.4E-7 T 17-03-2017 SHXM_RS50350 1363c4afd37a2a709a79568524d51506 153 SUPERFAMILY SSF82784 13 131 1.96E-19 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS50350 1363c4afd37a2a709a79568524d51506 153 Gene3D G3DSA:3.30.300.20 25 127 5.5E-17 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS50350 1363c4afd37a2a709a79568524d51506 153 Pfam PF02566 OsmC-like protein 37 128 7.7E-14 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS26000 a1b64500043e238bb9d0c7a982cab140 578 Pfam PF07681 DoxX 239 340 4.1E-12 T 17-03-2017 IPR032808 DoxX family SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 SUPERFAMILY SSF52172 3 160 4.7E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 SMART SM00448 3 113 1.1E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 SMART SM00862 144 219 9.4E-19 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 Gene3D G3DSA:3.40.50.2300 2 120 3.1E-32 T 17-03-2017 SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 SUPERFAMILY SSF46894 126 219 3.4E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 Gene3D G3DSA:1.10.10.10 123 219 1.0E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 Pfam PF00486 Transcriptional regulatory protein, C terminal 144 219 1.3E-18 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS45930 3697fe4c2034d8f593481e54c9fc6fc5 220 Pfam PF00072 Response regulator receiver domain 5 113 2.4E-19 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS47900 137783d6b65cdac69e2ed30258d68c97 310 SUPERFAMILY SSF51569 1 302 1.9E-64 T 17-03-2017 SHXM_RS47900 137783d6b65cdac69e2ed30258d68c97 310 Pfam PF00682 HMGL-like 5 284 2.6E-41 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS47900 137783d6b65cdac69e2ed30258d68c97 310 Gene3D G3DSA:3.20.20.70 4 296 1.2E-65 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 72 1.1E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 Gene3D G3DSA:1.10.357.10 70 227 3.2E-40 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 SUPERFAMILY SSF48498 104 224 3.88E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 5.7E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 5.7E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 SUPERFAMILY SSF46689 17 86 7.7E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 Pfam PF14246 AefR-like transcriptional repressor, C-terminal region 172 225 4.2E-8 T 17-03-2017 SHXM_RS34815 0132bf3640b97741de687c38f99e59f0 227 Gene3D G3DSA:1.10.10.60 14 69 8.4E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 SUPERFAMILY SSF51735 141 316 1.71E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 Pfam PF00107 Zinc-binding dehydrogenase 177 283 2.4E-16 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 58 72 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 SUPERFAMILY SSF50129 1 181 5.48E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 Gene3D G3DSA:3.40.50.720 174 281 2.3E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 Gene3D G3DSA:3.90.180.10 1 173 6.0E-35 T 17-03-2017 IPR011032 GroES-like SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 SMART SM00829 10 347 0.0013 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS47570 f10e0df243c5e36d3ceb70d5b8aa4196 354 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 120 3.4E-13 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS46120 97e73bb523da68ac23d4e359753d9401 664 SUPERFAMILY SSF48208 84 420 4.57E-26 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS46120 97e73bb523da68ac23d4e359753d9401 664 Gene3D G3DSA:1.50.10.10 121 295 5.3E-11 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS46120 97e73bb523da68ac23d4e359753d9401 664 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 23 554 2.0E-133 T 17-03-2017 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 Pfam PF04055 Radical SAM superfamily 69 251 8.2E-13 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 Pfam PF04055 Radical SAM superfamily 528 688 6.0E-15 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 SMART SM00729 65 302 1.2E-6 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 Hamap MF_01611 FO synthase subunit 1 [cofG]. 61 392 50.404 T 17-03-2017 IPR019939 CofG family GO:0009108|GO:0016765|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 520 828 2.9E-108 T 17-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 Hamap MF_01612 FO synthase subunit 2 [cofH]. 467 831 48.038 T 17-03-2017 IPR019940 CofH family GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 TIGRFAM TIGR03550 F420_cofG: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofG subunit 62 390 3.3E-142 T 17-03-2017 IPR019939 CofG family GO:0009108|GO:0016765|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 TIGRFAM TIGR03551 F420_cofH: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit 486 830 4.6E-160 T 17-03-2017 IPR019940 CofH family GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 SUPERFAMILY SSF102114 483 794 1.57E-48 T 17-03-2017 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 Gene3D G3DSA:3.20.20.70 21 355 3.8E-64 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 Gene3D G3DSA:3.20.20.70 484 818 3.5E-74 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS49010 bfbdd329aa02ef1de44ae3b8e3d39f72 854 SUPERFAMILY SSF102114 22 367 5.89E-35 T 17-03-2017 SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 Pfam PF13404 AsnC-type helix-turn-helix domain 1 41 1.3E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 Gene3D G3DSA:3.30.70.920 54 142 1.8E-18 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 Pfam PF01037 Lrp/AsnC ligand binding domain 76 139 8.5E-17 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 17 28 1.8E-13 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 1 17 1.8E-13 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 28 47 1.8E-13 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 Gene3D G3DSA:1.10.10.10 1 52 5.9E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 SUPERFAMILY SSF54909 66 143 1.88E-15 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 SUPERFAMILY SSF46785 1 59 2.58E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10545 60ba581001c7f869dbb971104c1acfd0 157 SMART SM00344 1 110 4.7E-34 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 Gene3D G3DSA:3.40.50.2300 2 130 4.5E-31 T 17-03-2017 SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 SUPERFAMILY SSF52172 1 116 9.39E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 SUPERFAMILY SSF46894 123 212 1.96E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 SMART SM00862 143 212 1.0E-15 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 SMART SM00448 1 110 6.3E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 Gene3D G3DSA:1.10.10.10 131 212 3.1E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 Pfam PF00486 Transcriptional regulatory protein, C terminal 144 212 8.6E-14 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS46515 427755b997dea66125b1ae6ed2735c65 215 Pfam PF00072 Response regulator receiver domain 2 111 3.9E-22 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS47275 62a9bdc5ef6866d13967f4e13e7743a0 290 PIRSF PIRSF029755 19 275 5.2E-102 T 17-03-2017 IPR016938 Uncharacterised protein family UPF0317 SHXM_RS47275 62a9bdc5ef6866d13967f4e13e7743a0 290 Gene3D G3DSA:3.40.1640.10 22 179 1.7E-54 T 17-03-2017 SHXM_RS47275 62a9bdc5ef6866d13967f4e13e7743a0 290 Hamap MF_01830 UPF0317 protein . 23 282 47.841 T 17-03-2017 IPR016938 Uncharacterised protein family UPF0317 SHXM_RS47275 62a9bdc5ef6866d13967f4e13e7743a0 290 Pfam PF07286 Protein of unknown function (DUF1445) 127 269 4.8E-54 T 17-03-2017 IPR009906 Protein of unknown function DUF1445 SHXM_RS47275 62a9bdc5ef6866d13967f4e13e7743a0 290 SUPERFAMILY SSF160920 23 270 1.31E-96 T 17-03-2017 SHXM_RS30600 1579a144aa6873e8f585ab205e22bd33 232 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 16 202 5.3E-35 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS30600 1579a144aa6873e8f585ab205e22bd33 232 SUPERFAMILY SSF53254 13 205 1.66E-36 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS30600 1579a144aa6873e8f585ab205e22bd33 232 Gene3D G3DSA:3.40.50.1240 15 204 2.4E-31 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS30600 1579a144aa6873e8f585ab205e22bd33 232 SMART SM00855 14 166 3.9E-15 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 SUPERFAMILY SSF53850 89 293 2.9E-34 T 17-03-2017 SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 Pfam PF03466 LysR substrate binding domain 88 293 1.9E-39 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 Gene3D G3DSA:3.40.190.10 183 266 1.0E-21 T 17-03-2017 SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 Gene3D G3DSA:3.40.190.10 91 182 9.8E-19 T 17-03-2017 SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 62 1.4E-13 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 SUPERFAMILY SSF46785 1 109 1.23E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42495 e32ad096f6e024c2792a9983482f5047 315 Gene3D G3DSA:1.10.10.10 4 88 3.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 SUPERFAMILY SSF48557 29 483 9.58E-140 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 PRINTS PR00149 Fumarate lyase superfamily signature 204 222 1.1E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 PRINTS PR00149 Fumarate lyase superfamily signature 341 357 1.1E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 PRINTS PR00149 Fumarate lyase superfamily signature 295 322 1.1E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 PRINTS PR00149 Fumarate lyase superfamily signature 158 176 1.1E-28 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 Hamap MF_00743 Fumarate hydratase class II [fumC]. 28 486 78.197 T 17-03-2017 IPR005677 Fumarate hydratase, class II GO:0004333|GO:0006106|GO:0045239 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 Gene3D G3DSA:1.10.275.10 28 162 2.1E-53 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 Gene3D G3DSA:1.20.200.10 163 426 6.5E-90 T 17-03-2017 SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 ProSitePatterns PS00163 Fumarate lyases signature. 341 350 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 Pfam PF00206 Lyase 36 365 8.4E-93 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 Gene3D G3DSA:1.10.40.30 429 485 5.8E-23 T 17-03-2017 SHXM_RS03380 11ec8d145110b315004c1863c25eb52a 489 Pfam PF10415 Fumarase C C-terminus 432 484 3.6E-20 T 17-03-2017 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 Gene3D G3DSA:3.40.50.1360 170 233 7.2E-15 T 17-03-2017 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 Gene3D G3DSA:3.40.50.1360 84 137 7.2E-15 T 17-03-2017 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 Gene3D G3DSA:1.10.10.10 11 68 4.0E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 SUPERFAMILY SSF46785 10 72 4.5E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 44 62 3.3E-9 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 30 44 3.3E-9 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 SUPERFAMILY SSF100950 172 252 3.21E-29 T 17-03-2017 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 SUPERFAMILY SSF100950 84 139 3.21E-29 T 17-03-2017 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 SMART SM00420 12 64 3.1E-17 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 Pfam PF08220 DeoR-like helix-turn-helix domain 12 63 3.1E-16 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 ProSitePatterns PS00894 DeoR-type HTH domain signature. 12 46 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 Pfam PF00455 DeoR C terminal sensor domain 84 251 3.3E-47 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS43280 ab371b6d6eaa251b9a4ab63a806bb003 281 SMART SM01134 80 253 9.9E-54 T 17-03-2017 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 Gene3D G3DSA:1.10.1040.10 191 330 1.9E-32 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 TIGRFAM TIGR00872 gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating) 7 341 2.7E-121 T 17-03-2017 IPR004849 6-phosphogluconate dehydrogenase, YqeC-type GO:0055114 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 178 206 5.0E-13 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 7 30 5.0E-13 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 SUPERFAMILY SSF51735 7 165 5.7E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 8 159 2.8E-37 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 Pfam PF00393 6-phosphogluconate dehydrogenase, C-terminal domain 189 217 4.1E-9 T 17-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 SMART SM01350 189 344 1.0E-4 T 17-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 Gene3D G3DSA:3.40.50.720 4 190 2.2E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13825 984339e273e08c08f4246305774afdb1 344 SUPERFAMILY SSF48179 187 341 4.76E-35 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS21660 5541797785fcc2b9139aefee5fc3aaa5 117 Pfam PF14017 Protein of unknown function (DUF4233) 2 105 7.6E-32 T 17-03-2017 IPR025327 Protein of unknown function DUF4233 SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 Hamap MF_02112 Proteasome-associated ATPase [mpa]. 54 566 50.241 T 17-03-2017 IPR022482 Proteasome ATPase GO:0000502|GO:0010498|GO:0016887|GO:0019941 SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 Gene3D G3DSA:3.40.50.300 218 433 3.3E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 ProSitePatterns PS00674 AAA-protein family signature. 387 405 - T 17-03-2017 IPR003960 ATPase, AAA-type, conserved site GO:0005524 SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 Pfam PF16450 Proteasomal ATPase OB/ID domain 97 226 4.1E-53 T 17-03-2017 IPR032501 Proteasomal ATPase, OB/ID domain SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 TIGRFAM TIGR03689 pup_AAA: proteasome ATPase 52 565 1.9E-252 T 17-03-2017 IPR022482 Proteasome ATPase GO:0000502|GO:0010498|GO:0016887|GO:0019941 SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 269 417 6.9E-48 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 SMART SM00382 265 419 6.5E-22 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 SUPERFAMILY SSF52540 475 515 7.25E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15930 8b5c04457b965018fff8f886f2a21880 588 SUPERFAMILY SSF52540 227 434 7.25E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 142 163 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 Pfam PF00107 Zinc-binding dehydrogenase 153 271 3.1E-31 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 Gene3D G3DSA:3.40.50.720 148 263 1.8E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 SUPERFAMILY SSF51735 114 272 1.37E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 SUPERFAMILY SSF50129 1 142 1.08E-35 T 17-03-2017 IPR011032 GroES-like SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 Gene3D G3DSA:3.90.180.10 1 147 8.4E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 SMART SM00829 13 324 4.6E-37 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS45030 b17dc85de4efbc121856b16f96831bd7 334 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 93 3.9E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 Pfam PF13411 MerR HTH family regulatory protein 1 67 1.1E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 Gene3D G3DSA:1.10.1660.10 1 115 1.9E-27 T 17-03-2017 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 2.5E-6 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 2.5E-6 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 2.5E-6 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 SMART SM00422 1 69 1.9E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS18375 a38bde6c62088fa07a86a7dfe5c42e65 121 SUPERFAMILY SSF46955 1 114 1.28E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS21825 6c0242b75b20a1f10140ce124ff4bb47 211 Pfam PF01323 DSBA-like thioredoxin domain 10 169 2.1E-8 T 17-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 SHXM_RS21825 6c0242b75b20a1f10140ce124ff4bb47 211 Gene3D G3DSA:3.40.30.10 6 169 2.8E-12 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS21825 6c0242b75b20a1f10140ce124ff4bb47 211 SUPERFAMILY SSF52833 10 171 2.15E-22 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS43330 cc9ac4fb7f92cc0588fb9948634763d3 465 Gene3D G3DSA:2.60.60.30 12 164 5.0E-37 T 17-03-2017 SHXM_RS43330 cc9ac4fb7f92cc0588fb9948634763d3 465 PIRSF PIRSF037118 1 465 3.9E-169 T 17-03-2017 IPR017115 Tellurite resistance, TerA SHXM_RS43330 cc9ac4fb7f92cc0588fb9948634763d3 465 Pfam PF02342 TerD domain 2 166 6.4E-47 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS41535 7b08554393a064c00122aa72446bb391 324 SUPERFAMILY SSF50129 1 138 5.97E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS41535 7b08554393a064c00122aa72446bb391 324 Pfam PF00107 Zinc-binding dehydrogenase 152 269 9.2E-17 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS41535 7b08554393a064c00122aa72446bb391 324 Gene3D G3DSA:3.90.180.10 1 146 4.7E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS41535 7b08554393a064c00122aa72446bb391 324 Gene3D G3DSA:3.40.50.720 147 264 2.4E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41535 7b08554393a064c00122aa72446bb391 324 SMART SM00829 10 322 7.8E-11 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS41535 7b08554393a064c00122aa72446bb391 324 SUPERFAMILY SSF51735 113 293 1.06E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17715 4932ac61f1687d4d1fc77b28ccf63c9d 315 Gene3D G3DSA:3.20.20.70 7 303 2.5E-76 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS17715 4932ac61f1687d4d1fc77b28ccf63c9d 315 Hamap MF_00694 Probable 5-dehydro-4-deoxyglucarate dehydratase. 4 305 47.971 T 17-03-2017 IPR017655 5-dehydro-4-deoxyglucarate dehydratase GO:0016052|GO:0047448 KEGG: 00053+4.2.1.41|MetaCyc: PWY-6486|MetaCyc: PWY-6497|MetaCyc: PWY-6499|MetaCyc: PWY-6501 SHXM_RS17715 4932ac61f1687d4d1fc77b28ccf63c9d 315 PIRSF PIRSF001365 6 314 1.1E-57 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS17715 4932ac61f1687d4d1fc77b28ccf63c9d 315 Pfam PF00701 Dihydrodipicolinate synthetase family 11 301 1.2E-55 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS17715 4932ac61f1687d4d1fc77b28ccf63c9d 315 SUPERFAMILY SSF51569 8 301 4.4E-66 T 17-03-2017 SHXM_RS17715 4932ac61f1687d4d1fc77b28ccf63c9d 315 SMART SM01130 9 303 1.7E-75 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS41285 b06b769807764735fc7d762558290af2 331 SUPERFAMILY SSF51430 8 329 5.76E-74 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS41285 b06b769807764735fc7d762558290af2 331 Gene3D G3DSA:3.20.20.100 7 329 1.9E-75 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS41285 b06b769807764735fc7d762558290af2 331 Pfam PF00248 Aldo/keto reductase family 20 328 3.5E-57 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS44420 618a83e7627dacba31124b207a2db3d8 518 SUPERFAMILY SSF53335 8 181 1.91E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44420 618a83e7627dacba31124b207a2db3d8 518 Gene3D G3DSA:3.40.50.150 8 180 1.7E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44420 618a83e7627dacba31124b207a2db3d8 518 Pfam PF00145 C-5 cytosine-specific DNA methylase 22 178 2.4E-18 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24885 a548df4cb48bd46a71c4a27e08c52132 416 SMART SM00530 19 75 8.0E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS24885 a548df4cb48bd46a71c4a27e08c52132 416 Gene3D G3DSA:1.10.260.40 16 81 6.0E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS24885 a548df4cb48bd46a71c4a27e08c52132 416 Pfam PF13560 Helix-turn-helix domain 16 72 3.7E-12 T 17-03-2017 SHXM_RS24885 a548df4cb48bd46a71c4a27e08c52132 416 SUPERFAMILY SSF47413 11 72 1.01E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 SUPERFAMILY SSF51735 7 163 9.06E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 11 129 2.9E-19 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 SUPERFAMILY SSF55347 149 335 1.8E-23 T 17-03-2017 SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 149 201 5.4E-5 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 Gene3D G3DSA:3.30.360.10 156 285 1.2E-28 T 17-03-2017 SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 Gene3D G3DSA:3.30.360.10 320 366 1.2E-28 T 17-03-2017 SHXM_RS05060 5d4814f186dfb856360239b2b32b5870 374 Gene3D G3DSA:3.40.50.720 8 155 3.8E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44975 f35107b7d3d339fc8b651817604732a5 332 SMART SM00849 27 234 6.8E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS44975 f35107b7d3d339fc8b651817604732a5 332 Pfam PF00753 Metallo-beta-lactamase superfamily 24 234 5.6E-16 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS44975 f35107b7d3d339fc8b651817604732a5 332 SUPERFAMILY SSF56281 8 275 7.98E-48 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS44975 f35107b7d3d339fc8b651817604732a5 332 Gene3D G3DSA:3.60.15.10 140 258 6.1E-40 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS44975 f35107b7d3d339fc8b651817604732a5 332 Gene3D G3DSA:3.60.15.10 8 106 6.1E-40 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS29290 f9603d51f5e6e69b4f5a3732fd27512f 305 ProSitePatterns PS00211 ABC transporters family signature. 131 145 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS29290 f9603d51f5e6e69b4f5a3732fd27512f 305 SUPERFAMILY SSF52540 4 219 1.78E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29290 f9603d51f5e6e69b4f5a3732fd27512f 305 Pfam PF00005 ABC transporter 20 159 9.0E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS29290 f9603d51f5e6e69b4f5a3732fd27512f 305 Pfam PF13732 Domain of unknown function (DUF4162) 212 289 2.9E-7 T 17-03-2017 IPR025302 Domain of unknown function DUF4162 SHXM_RS29290 f9603d51f5e6e69b4f5a3732fd27512f 305 Gene3D G3DSA:3.40.50.300 2 229 2.1E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29290 f9603d51f5e6e69b4f5a3732fd27512f 305 SMART SM00382 29 208 1.3E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37630 7cf3eedf8dc347881e03c284a8cf76bc 171 Pfam PF00692 dUTPase 17 147 8.6E-29 T 17-03-2017 IPR008180 Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase GO:0016787|GO:0046080 SHXM_RS37630 7cf3eedf8dc347881e03c284a8cf76bc 171 Hamap MF_00116 Deoxyuridine 5'-triphosphate nucleotidohydrolase [dut]. 6 148 30.932 T 17-03-2017 IPR008181 Deoxyuridine triphosphate nucleotidohydrolase GO:0004170|GO:0046080 KEGG: 00240+3.6.1.23|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7206|Reactome: R-HSA-500753 SHXM_RS37630 7cf3eedf8dc347881e03c284a8cf76bc 171 TIGRFAM TIGR00576 dut: dUTP diphosphatase 9 147 1.9E-49 T 17-03-2017 IPR008181 Deoxyuridine triphosphate nucleotidohydrolase GO:0004170|GO:0046080 KEGG: 00240+3.6.1.23|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7206|Reactome: R-HSA-500753 SHXM_RS37630 7cf3eedf8dc347881e03c284a8cf76bc 171 SUPERFAMILY SSF51283 5 147 4.06E-42 T 17-03-2017 IPR029054 dUTPase-like SHXM_RS37630 7cf3eedf8dc347881e03c284a8cf76bc 171 Gene3D G3DSA:2.70.40.10 7 147 1.0E-50 T 17-03-2017 IPR029054 dUTPase-like SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SUPERFAMILY SSF50998 892 1118 5.94E-26 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SUPERFAMILY SSF50998 709 836 5.94E-26 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SUPERFAMILY SSF117074 211 261 1.44E-6 T 17-03-2017 SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 Gene3D G3DSA:2.140.10.10 707 1120 9.1E-57 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 Pfam PF16371 N terminal of Calcineurin-like phosphoesterase 233 308 1.5E-11 T 17-03-2017 IPR032285 Calcineurin-like phosphoesterase, N-terminal SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 Pfam PF00149 Calcineurin-like phosphoesterase 358 510 9.2E-6 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SMART SM00564 1060 1091 7.6E-5 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SMART SM00564 798 829 1.2 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SMART SM00564 943 978 690.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SMART SM00564 995 1029 38.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SMART SM00564 752 789 1.2 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 Pfam PF13360 PQQ-like domain 753 834 5.6E-11 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 Pfam PF13360 PQQ-like domain 1009 1121 6.0E-8 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 Gene3D G3DSA:3.60.21.10 321 517 2.4E-22 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18990 50a4a1811dbbbf111cef7cee9e29a569 1124 SUPERFAMILY SSF56300 348 519 4.32E-24 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS49510 b965ddbab6ad1472117f0723a9f9d5d0 146 TIGRFAM TIGR03293 PhnG_redo: phosphonate C-P lyase system protein PhnG 6 145 1.6E-27 T 17-03-2017 IPR009609 Phosphonate metabolism PhnG GO:0015716|GO:0019634 KEGG: 00440+2.7.8.37|MetaCyc: PWY-7399 SHXM_RS49510 b965ddbab6ad1472117f0723a9f9d5d0 146 Pfam PF06754 Phosphonate metabolism protein PhnG 6 144 1.9E-24 T 17-03-2017 IPR009609 Phosphonate metabolism PhnG GO:0015716|GO:0019634 KEGG: 00440+2.7.8.37|MetaCyc: PWY-7399 SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 Gene3D G3DSA:1.10.10.10 140 195 1.2E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 Gene3D G3DSA:3.30.750.24 9 111 1.0E-13 T 17-03-2017 IPR002645 STAS domain SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 SMART SM01012 137 193 7.6E-16 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 SUPERFAMILY SSF52091 10 110 7.85E-12 T 17-03-2017 IPR002645 STAS domain SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 Gene3D G3DSA:3.30.450.40 232 369 3.3E-9 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 Pfam PF03861 ANTAR domain 140 193 5.4E-17 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 Pfam PF01590 GAF domain 231 367 2.3E-4 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS06015 77194d50cf72c5dbfb24d78695b3b165 416 SUPERFAMILY SSF55781 231 373 1.92E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS40575 e104bd93147b6a7ae46644b9c3f838cb 110 Gene3D G3DSA:3.30.70.1060 3 108 7.2E-10 T 17-03-2017 SHXM_RS40575 e104bd93147b6a7ae46644b9c3f838cb 110 Pfam PF03795 YCII-related domain 3 108 8.6E-7 T 17-03-2017 IPR005545 YCII-related SHXM_RS40575 e104bd93147b6a7ae46644b9c3f838cb 110 SUPERFAMILY SSF54909 16 108 1.53E-9 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS48790 b8b685570a8a9cb8dd5a1abb4497f711 274 Gene3D G3DSA:3.40.50.150 41 258 1.0E-22 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS48790 b8b685570a8a9cb8dd5a1abb4497f711 274 SUPERFAMILY SSF53335 41 250 9.56E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS48790 b8b685570a8a9cb8dd5a1abb4497f711 274 Pfam PF13649 Methyltransferase domain 57 152 3.2E-10 T 17-03-2017 SHXM_RS27795 750e5da2ff5552e04c4baf078e179895 333 PIRSF PIRSF000267 1 333 1.1E-120 T 17-03-2017 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 SHXM_RS27795 750e5da2ff5552e04c4baf078e179895 333 TIGRFAM TIGR00203 cydB: cytochrome d ubiquinol oxidase, subunit II 3 214 2.7E-71 T 17-03-2017 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 SHXM_RS27795 750e5da2ff5552e04c4baf078e179895 333 Pfam PF02322 Cytochrome bd terminal oxidase subunit II 3 320 7.5E-115 T 17-03-2017 IPR003317 Cytochrome ubiquinol oxidase subunit 2 GO:0016020|GO:0055114 SHXM_RS12145 1edb529146b0409c67a27ab156e640f1 94 SUPERFAMILY SSF101386 9 94 2.83E-20 T 17-03-2017 SHXM_RS12145 1edb529146b0409c67a27ab156e640f1 94 TIGRFAM TIGR03188 histidine_hisI: phosphoribosyl-ATP diphosphatase 11 94 2.3E-24 T 17-03-2017 IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase GO:0000105|GO:0004636 KEGG: 00340+3.6.1.31 SHXM_RS12145 1edb529146b0409c67a27ab156e640f1 94 Pfam PF01503 Phosphoribosyl-ATP pyrophosphohydrolase 16 93 3.1E-10 T 17-03-2017 IPR021130 Phosphoribosyl-ATP pyrophosphohydrolase-like KEGG: 00340+3.6.1.31 SHXM_RS12145 1edb529146b0409c67a27ab156e640f1 94 Hamap MF_01020 Phosphoribosyl-ATP pyrophosphatase [hisE]. 7 94 19.148 T 17-03-2017 IPR008179 Phosphoribosyl-ATP pyrophosphohydrolase GO:0000105|GO:0004636 KEGG: 00340+3.6.1.31 SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 Pfam PF01571 Aminomethyltransferase folate-binding domain 22 141 8.7E-18 T 17-03-2017 IPR006222 Glycine cleavage T-protein-like, N-terminal SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 TIGRFAM TIGR03317 ygfZ_signature: folate-binding protein YgfZ 186 250 3.8E-21 T 17-03-2017 IPR017703 YgfZ/GcvT conserved site SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 Gene3D G3DSA:2.40.30.110 241 308 4.9E-5 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 224 298 3.1E-9 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 Gene3D G3DSA:3.30.70.1400 47 132 2.4E-12 T 17-03-2017 SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 SUPERFAMILY SSF103025 22 240 1.24E-53 T 17-03-2017 SHXM_RS30060 087c8ddc27c4c7382e9b50b714dcb947 321 SUPERFAMILY SSF101790 243 309 6.54E-5 T 17-03-2017 IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain SHXM_RS33125 75b6bbd668e61af4481e5a09e5dcb7ef 357 Gene3D G3DSA:3.40.50.280 102 215 2.8E-17 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS33125 75b6bbd668e61af4481e5a09e5dcb7ef 357 Pfam PF02607 B12 binding domain 19 82 9.1E-11 T 17-03-2017 IPR003759 Cobalamin (vitamin B12)-binding module, cap domain Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS33125 75b6bbd668e61af4481e5a09e5dcb7ef 357 SUPERFAMILY SSF52242 99 218 2.09E-19 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS33125 75b6bbd668e61af4481e5a09e5dcb7ef 357 Pfam PF02310 B12 binding domain 104 217 5.5E-16 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS30750 917be9a9d2ae829e04f298e0f908fbaa 275 SUPERFAMILY SSF54001 155 274 1.23E-36 T 17-03-2017 SHXM_RS30750 917be9a9d2ae829e04f298e0f908fbaa 275 Gene3D G3DSA:3.90.1720.10 155 275 4.6E-38 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS30750 917be9a9d2ae829e04f298e0f908fbaa 275 Pfam PF00877 NlpC/P60 family 173 262 1.9E-21 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS48670 945b406bc7f96441c63845ea830474be 311 Gene3D G3DSA:1.10.3720.10 62 282 2.3E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48670 945b406bc7f96441c63845ea830474be 311 SUPERFAMILY SSF161098 63 283 3.01E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48670 945b406bc7f96441c63845ea830474be 311 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 83 282 1.7E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48670 945b406bc7f96441c63845ea830474be 311 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 63 177 1.2E-19 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS50970 ce55edc505f3cf69dfbfbd0b271d1330 724 SUPERFAMILY SSF53098 363 468 2.28E-13 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50970 ce55edc505f3cf69dfbfbd0b271d1330 724 Pfam PF00665 Integrase core domain 353 415 5.0E-9 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS50970 ce55edc505f3cf69dfbfbd0b271d1330 724 Gene3D G3DSA:3.30.420.10 255 322 8.0E-21 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50970 ce55edc505f3cf69dfbfbd0b271d1330 724 Gene3D G3DSA:3.30.420.10 358 467 8.0E-21 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS19830 cfe75b87a017753d2b102ef841036585 176 Pfam PF13302 Acetyltransferase (GNAT) domain 9 146 3.5E-24 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS19830 cfe75b87a017753d2b102ef841036585 176 SUPERFAMILY SSF55729 2 148 1.58E-30 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19830 cfe75b87a017753d2b102ef841036585 176 Gene3D G3DSA:3.40.630.30 2 163 1.0E-34 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS11530 aa74308d09be2cb166e7bc50ea351bd1 144 Pfam PF04066 Multiple resistance and pH regulation protein F (MrpF / PhaF) 32 82 1.6E-11 T 17-03-2017 IPR007208 Na(+)/H(+) antiporter subunit F-like GO:0015075|GO:0016021|GO:0034220 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 239 247 7.2E-8 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 123 145 7.2E-8 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 328 344 7.2E-8 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 SUPERFAMILY SSF101790 870 969 1.03E-14 T 17-03-2017 IPR029043 Glycine cleavage T-protein/YgfZ, C-terminal domain SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 TIGRFAM TIGR01372 soxA: sarcosine oxidase, alpha subunit family 101 971 0.0 T 17-03-2017 IPR006277 Sarcosine oxidase, alpha subunit GO:0008115|GO:0046653 KEGG: 00260+1.5.3.1|MetaCyc: PWY-3661|MetaCyc: PWY-4722 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Pfam PF01571 Aminomethyltransferase folate-binding domain 585 851 2.6E-72 T 17-03-2017 IPR006222 Glycine cleavage T-protein-like, N-terminal SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 124 143 7.5E-8 T 17-03-2017 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 238 256 7.5E-8 T 17-03-2017 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 SUPERFAMILY SSF103025 578 866 5.02E-90 T 17-03-2017 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Gene3D G3DSA:3.30.70.1400 638 722 2.2E-22 T 17-03-2017 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Pfam PF08669 Glycine cleavage T-protein C-terminal barrel domain 856 958 3.5E-13 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 PIRSF PIRSF037980 98 972 0.0 T 17-03-2017 IPR006277 Sarcosine oxidase, alpha subunit GO:0008115|GO:0046653 KEGG: 00260+1.5.3.1|MetaCyc: PWY-3661|MetaCyc: PWY-4722 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 19 100 2.7E-19 T 17-03-2017 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 SUPERFAMILY SSF51905 116 437 4.73E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Gene3D G3DSA:3.50.50.60 115 262 8.9E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Gene3D G3DSA:3.50.50.60 309 394 8.9E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 123 392 5.3E-14 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Gene3D G3DSA:3.30.1360.120 730 828 4.8E-33 T 17-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Gene3D G3DSA:3.30.1360.120 580 637 4.8E-33 T 17-03-2017 IPR027266 GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 GO:0005515 SHXM_RS41785 452f9093ac9722d6bbd52b563b744216 972 Gene3D G3DSA:2.40.30.110 874 971 5.1E-19 T 17-03-2017 IPR013977 Glycine cleavage T-protein, C-terminal barrel domain KEGG: 00260+2.1.2.10|KEGG: 00670+2.1.2.10 SHXM_RS41410 9d66cb07e41b4fa28ab7fa4913e9f773 355 Gene3D G3DSA:1.10.600.10 15 353 7.0E-70 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS41410 9d66cb07e41b4fa28ab7fa4913e9f773 355 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 233 245 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS41410 9d66cb07e41b4fa28ab7fa4913e9f773 355 Pfam PF00348 Polyprenyl synthetase 49 298 9.3E-41 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS41410 9d66cb07e41b4fa28ab7fa4913e9f773 355 SUPERFAMILY SSF48576 21 349 3.36E-65 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS15395 edd3ed0c0b1707c133fc4f6b2e702ab4 362 Pfam PF13683 Integrase core domain 263 326 4.0E-15 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15395 edd3ed0c0b1707c133fc4f6b2e702ab4 362 SUPERFAMILY SSF46689 73 154 9.68E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15395 edd3ed0c0b1707c133fc4f6b2e702ab4 362 Gene3D G3DSA:3.30.420.10 168 326 1.9E-14 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15395 edd3ed0c0b1707c133fc4f6b2e702ab4 362 SUPERFAMILY SSF53098 173 328 1.82E-18 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09315 fb64661abb0e5b6c2e638ad78b4d183f 256 SUPERFAMILY SSF50998 13 253 1.28E-24 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS09315 fb64661abb0e5b6c2e638ad78b4d183f 256 Gene3D G3DSA:2.130.10.10 11 251 4.8E-20 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 Gene3D G3DSA:3.40.1190.20 4 307 3.5E-94 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 SUPERFAMILY SSF53613 4 307 3.12E-76 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 TIGRFAM TIGR02152 D_ribokin_bact: ribokinase 7 306 8.0E-91 T 17-03-2017 IPR011877 Ribokinase GO:0004747|GO:0006014 KEGG: 00030+2.7.1.15 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 Hamap MF_01987 Ribokinase [rbsK]. 4 308 25.92 T 17-03-2017 IPR011877 Ribokinase GO:0004747|GO:0006014 KEGG: 00030+2.7.1.15 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 Pfam PF00294 pfkB family carbohydrate kinase 6 301 1.2E-63 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 PRINTS PR00990 Ribokinase signature 179 194 2.0E-33 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 PRINTS PR00990 Ribokinase signature 8 29 2.0E-33 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 PRINTS PR00990 Ribokinase signature 35 54 2.0E-33 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 PRINTS PR00990 Ribokinase signature 224 235 2.0E-33 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 PRINTS PR00990 Ribokinase signature 106 119 2.0E-33 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS22340 1345de88b74eee5977317844b7c61170 308 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 253 266 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS23740 05e6751d100254a193a8b72c91824461 464 SUPERFAMILY SSF103473 17 442 2.35E-39 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23740 05e6751d100254a193a8b72c91824461 464 Pfam PF07690 Major Facilitator Superfamily 48 396 2.9E-19 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23740 05e6751d100254a193a8b72c91824461 464 Gene3D G3DSA:1.20.1250.20 47 220 1.3E-10 T 17-03-2017 SHXM_RS23740 05e6751d100254a193a8b72c91824461 464 Gene3D G3DSA:1.20.1250.20 235 434 1.4E-14 T 17-03-2017 SHXM_RS27500 176b48c37b10fd33ad06c3ea96c433f9 286 Gene3D G3DSA:1.25.40.10 164 248 1.4E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS27500 176b48c37b10fd33ad06c3ea96c433f9 286 Gene3D G3DSA:1.25.40.10 48 114 1.4E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS27500 176b48c37b10fd33ad06c3ea96c433f9 286 SUPERFAMILY SSF48452 180 250 3.25E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 SMART SM00633 85 338 1.8E-124 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 Pfam PF00331 Glycosyl hydrolase family 10 47 335 1.1E-106 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 SUPERFAMILY SSF51445 48 339 8.59E-107 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 ProSitePatterns PS00591 Glycosyl hydrolases family 10 (GH10) active site. 264 274 - T 17-03-2017 IPR031158 Glycosyl hydrolases family 10, active site MetaCyc: PWY-6784 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 Gene3D G3DSA:3.20.20.80 47 339 3.2E-110 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 PRINTS PR00134 Glycosyl hydrolase family 10 signature 231 243 2.7E-16 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 PRINTS PR00134 Glycosyl hydrolase family 10 signature 158 169 2.7E-16 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 PRINTS PR00134 Glycosyl hydrolase family 10 signature 202 213 2.7E-16 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS00880 8466056cb913daa66cd500493882ddf0 341 PRINTS PR00134 Glycosyl hydrolase family 10 signature 116 128 2.7E-16 T 17-03-2017 IPR001000 Glycoside hydrolase family 10 domain GO:0004553|GO:0005975 MetaCyc: PWY-6784 SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 137 149 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 Pfam PF00069 Protein kinase domain 15 265 6.7E-50 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 SUPERFAMILY SSF56112 7 327 1.21E-69 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 Gene3D G3DSA:3.30.200.20 7 83 1.0E-22 T 17-03-2017 SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 20 43 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 Gene3D G3DSA:1.10.510.10 84 268 3.2E-48 T 17-03-2017 SHXM_RS25455 021436e9d8f59a504358c7b27d3eb2d3 580 SMART SM00220 14 271 2.8E-63 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS08080 3388a37668abd5ab2115b36f85534ecb 252 Gene3D G3DSA:3.40.630.30 18 155 8.9E-29 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS08080 3388a37668abd5ab2115b36f85534ecb 252 SUPERFAMILY SSF55729 15 223 5.83E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS08080 3388a37668abd5ab2115b36f85534ecb 252 Pfam PF13444 Acetyltransferase (GNAT) domain 33 132 7.1E-29 T 17-03-2017 SHXM_RS45475 61088fb4e205da49ceb3bdbfb5be207c 177 SUPERFAMILY SSF47240 23 175 1.25E-32 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS45475 61088fb4e205da49ceb3bdbfb5be207c 177 Gene3D G3DSA:1.20.1260.10 28 175 1.1E-40 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS45475 61088fb4e205da49ceb3bdbfb5be207c 177 Pfam PF00210 Ferritin-like domain 39 175 5.1E-27 T 17-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SHXM_RS45475 61088fb4e205da49ceb3bdbfb5be207c 177 PIRSF PIRSF018063 12 177 2.3E-50 T 17-03-2017 IPR014490 Uncharacterised conserved protein UCP018063, ferritin fold SHXM_RS42160 93dff694d4b6b3b7abf53b46865fea7b 214 SUPERFAMILY SSF51569 5 208 4.21E-60 T 17-03-2017 SHXM_RS42160 93dff694d4b6b3b7abf53b46865fea7b 214 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 10 208 1.5E-67 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS42160 93dff694d4b6b3b7abf53b46865fea7b 214 ProSitePatterns PS00159 KDPG and KHG aldolases active site. 38 47 - T 17-03-2017 IPR031337 KDPG/KHG aldolase, active site 1 KEGG: 00030+4.1.2.14|KEGG: 00330+4.1.3.16|KEGG: 00630+4.1.3.16|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS42160 93dff694d4b6b3b7abf53b46865fea7b 214 Pfam PF01081 KDPG and KHG aldolase 10 200 1.8E-62 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS42160 93dff694d4b6b3b7abf53b46865fea7b 214 Gene3D G3DSA:3.20.20.70 4 211 9.4E-68 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:1.20.1580.10 300 372 8.0E-27 T 17-03-2017 SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:1.20.1580.10 103 172 8.0E-27 T 17-03-2017 SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:1.20.1580.10 585 711 1.6E-41 T 17-03-2017 SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 SUPERFAMILY SSF52540 523 802 1.94E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 SMART SM00382 527 801 0.042 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 SMART SM00382 35 459 1.1 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 ProSitePatterns PS00211 ABC transporters family signature. 721 735 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:1.10.8.280 177 299 2.6E-15 T 17-03-2017 SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:3.40.50.300 373 490 2.3E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:3.40.50.300 18 83 2.3E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:3.40.50.300 504 565 5.8E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 Gene3D G3DSA:3.40.50.300 712 828 5.8E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 SUPERFAMILY SSF52540 23 124 1.73E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50790 2d55bf9b43d4378ea43ef44b3a424cee 846 SUPERFAMILY SSF52540 309 469 1.73E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45690 06bd391c573251051dd292cb1fab2f09 383 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 5 121 2.7E-28 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS45690 06bd391c573251051dd292cb1fab2f09 383 SUPERFAMILY SSF55347 128 307 1.23E-26 T 17-03-2017 SHXM_RS45690 06bd391c573251051dd292cb1fab2f09 383 SUPERFAMILY SSF51735 2 155 8.79E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45690 06bd391c573251051dd292cb1fab2f09 383 Gene3D G3DSA:3.30.360.10 323 374 1.1E-28 T 17-03-2017 SHXM_RS45690 06bd391c573251051dd292cb1fab2f09 383 Gene3D G3DSA:3.30.360.10 143 278 1.1E-28 T 17-03-2017 SHXM_RS45690 06bd391c573251051dd292cb1fab2f09 383 Gene3D G3DSA:3.40.50.720 1 142 3.0E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Pfam PF04542 Sigma-70 region 2 102 172 7.0E-21 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Pfam PF00140 Sigma-70 factor, region 1.2 34 67 8.6E-11 T 17-03-2017 IPR009042 RNA polymerase sigma-70 region 1.2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Pfam PF04539 Sigma-70 region 3 181 257 2.0E-24 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Gene3D G3DSA:1.10.10.10 265 329 1.7E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Gene3D G3DSA:1.10.10.10 175 226 1.8E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 126 139 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 295 321 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Pfam PF04545 Sigma-70, region 4 271 323 4.4E-14 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 SUPERFAMILY SSF88946 32 172 5.76E-49 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 99 324 3.4E-33 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 SUPERFAMILY SSF88659 233 327 5.98E-23 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 SUPERFAMILY SSF88659 175 248 1.35E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 PRINTS PR00046 Major sigma-70 factor signature 274 286 1.5E-24 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 PRINTS PR00046 Major sigma-70 factor signature 295 310 1.5E-24 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 PRINTS PR00046 Major sigma-70 factor signature 150 158 1.5E-24 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 PRINTS PR00046 Major sigma-70 factor signature 310 321 1.5E-24 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 PRINTS PR00046 Major sigma-70 factor signature 126 139 1.5E-24 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32350 0a5340f49a792fb6286980f79c4d4eef 334 Gene3D G3DSA:1.10.601.10 25 171 5.4E-56 T 17-03-2017 SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 SUPERFAMILY SSF51735 13 255 4.77E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 197 214 8.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 90 101 8.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 16 33 8.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 8.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 174 193 8.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 Pfam PF00106 short chain dehydrogenase 16 220 3.5E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 174 193 3.0E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 3.0E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 90 101 3.0E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20790 31443eba55ff37e064c35e11b56882b8 310 Gene3D G3DSA:3.40.50.720 6 253 7.7E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 PRINTS PR00783 Major intrinsic protein family signature 195 217 9.5E-44 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 PRINTS PR00783 Major intrinsic protein family signature 84 103 9.5E-44 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 PRINTS PR00783 Major intrinsic protein family signature 162 180 9.5E-44 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 PRINTS PR00783 Major intrinsic protein family signature 242 262 9.5E-44 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 PRINTS PR00783 Major intrinsic protein family signature 47 71 9.5E-44 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 PRINTS PR00783 Major intrinsic protein family signature 5 24 9.5E-44 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 Pfam PF00230 Major intrinsic protein 6 259 1.0E-43 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 Gene3D G3DSA:1.20.1080.10 6 262 1.6E-81 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 SUPERFAMILY SSF81338 7 263 2.35E-63 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS15990 cd780e871eddddbb80b1ec02d481f955 264 ProSitePatterns PS00221 MIP family signature. 65 73 - T 17-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 Pfam PF01488 Shikimate / quinate 5-dehydrogenase 255 340 1.5E-7 T 17-03-2017 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 Pfam PF01488 Shikimate / quinate 5-dehydrogenase 184 232 5.1E-11 T 17-03-2017 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 Pfam PF00745 Glutamyl-tRNAGlu reductase, dimerisation domain 362 461 3.6E-20 T 17-03-2017 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 SUPERFAMILY SSF69075 360 462 3.66E-16 T 17-03-2017 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 Gene3D G3DSA:3.40.50.720 183 344 8.7E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 SUPERFAMILY SSF69742 1 158 1.31E-43 T 17-03-2017 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 TIGRFAM TIGR01035 hemA: glutamyl-tRNA reductase 4 462 9.1E-106 T 17-03-2017 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 PIRSF PIRSF000445 1 473 4.5E-128 T 17-03-2017 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 Hamap MF_00087 Glutamyl-tRNA reductase [hemA]. 2 459 25.301 T 17-03-2017 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 ProSitePatterns PS00747 Glutamyl-tRNA reductase signature. 99 122 - T 17-03-2017 IPR018214 Glutamyl-tRNA reductase, conserved site GO:0008883|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 Pfam PF05201 Glutamyl-tRNAGlu reductase, N-terminal domain 6 156 8.5E-44 T 17-03-2017 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal GO:0008883|GO:0033014|GO:0050661|GO:0055114 KEGG: 00860+1.2.1.70|MetaCyc: PWY-5188 SHXM_RS30460 07981396e9c7c73e9df3d02906f23f94 489 SUPERFAMILY SSF51735 182 339 2.24E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33635 f536bd785a055ac25d5784c7f5c94044 231 Pfam PF08044 Domain of unknown function (DUF1707) 35 87 2.4E-22 T 17-03-2017 IPR012551 Protein of unknown function DUF1707 SHXM_RS33635 f536bd785a055ac25d5784c7f5c94044 231 Pfam PF09922 Cell wall-active antibiotics response 4TMS YvqF 125 195 3.8E-10 T 17-03-2017 IPR024425 Cell wall-active antibiotics response 4TMS YvqF SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 SMART SM00846 3 153 5.6E-93 T 17-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 TIGRFAM TIGR01534 GAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I 4 325 1.3E-138 T 17-03-2017 IPR006424 Glyceraldehyde-3-phosphate dehydrogenase, type I GO:0006006|GO:0016620|GO:0050661|GO:0051287|GO:0055114 KEGG: 00010+1.2.1.12|KEGG: 00710+1.2.1.12|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6901|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 Gene3D G3DSA:3.40.50.720 2 161 3.4E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 270 285 9.6E-41 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 110 123 9.6E-41 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 147 165 9.6E-41 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 174 190 9.6E-41 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 PRINTS PR00078 Glyceraldehyde-3-phosphate dehydrogenase signature 230 247 9.6E-41 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 PIRSF PIRSF000149 1 333 4.0E-135 T 17-03-2017 IPR020831 Glyceraldehyde/Erythrose phosphate dehydrogenase family GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 SUPERFAMILY SSF51735 2 179 2.9E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 Pfam PF00044 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain 3 153 1.2E-59 T 17-03-2017 IPR020828 Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 Gene3D G3DSA:3.30.360.10 162 315 1.8E-75 T 17-03-2017 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 Pfam PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain 158 313 2.7E-69 T 17-03-2017 IPR020829 Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain GO:0016620|GO:0055114 Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17925 10458e50c8d00fe2f9ea3d083bf79a50 334 SUPERFAMILY SSF55347 153 314 5.66E-71 T 17-03-2017 SHXM_RS13485 c271a8b42127d24c9483327678ba2894 440 Pfam PF00246 Zinc carboxypeptidase 57 203 2.2E-21 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS13485 c271a8b42127d24c9483327678ba2894 440 SUPERFAMILY SSF53187 46 295 6.28E-39 T 17-03-2017 SHXM_RS13485 c271a8b42127d24c9483327678ba2894 440 SMART SM00631 48 275 7.3E-4 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS13485 c271a8b42127d24c9483327678ba2894 440 Gene3D G3DSA:3.40.630.10 47 328 3.1E-33 T 17-03-2017 SHXM_RS48680 fef05de7c7995f4230337035f5def203 386 Pfam PF01266 FAD dependent oxidoreductase 4 346 4.8E-39 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS48680 fef05de7c7995f4230337035f5def203 386 Gene3D G3DSA:3.50.50.60 310 368 6.5E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48680 fef05de7c7995f4230337035f5def203 386 Gene3D G3DSA:3.50.50.60 2 71 6.5E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48680 fef05de7c7995f4230337035f5def203 386 Gene3D G3DSA:3.50.50.60 139 222 6.5E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48680 fef05de7c7995f4230337035f5def203 386 SUPERFAMILY SSF51905 1 223 6.04E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48680 fef05de7c7995f4230337035f5def203 386 SUPERFAMILY SSF51905 310 365 6.04E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 Pfam PF01965 DJ-1/PfpI family 13 186 1.5E-11 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 Gene3D G3DSA:3.40.50.880 14 226 3.8E-47 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 Pfam PF12833 Helix-turn-helix domain 247 325 1.0E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 Gene3D G3DSA:1.10.10.60 227 279 5.1E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 278 320 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 SUPERFAMILY SSF52317 13 207 6.54E-45 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 SMART SM00342 241 324 3.2E-30 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 SUPERFAMILY SSF46689 278 328 4.58E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 Gene3D G3DSA:1.10.10.60 280 327 9.0E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31710 6891d78473723e57e8026fc348098f04 343 SUPERFAMILY SSF46689 229 275 1.75E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08375 acbf021648a4237d2e1a7bfebb2601ad 272 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 212 229 - T 17-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 SHXM_RS08375 acbf021648a4237d2e1a7bfebb2601ad 272 Gene3D G3DSA:3.40.1180.10 40 266 1.3E-79 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS08375 acbf021648a4237d2e1a7bfebb2601ad 272 SUPERFAMILY SSF64005 39 262 6.8E-70 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS08375 acbf021648a4237d2e1a7bfebb2601ad 272 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 40 267 34.978 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS08375 acbf021648a4237d2e1a7bfebb2601ad 272 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 41 266 1.1E-70 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS08375 acbf021648a4237d2e1a7bfebb2601ad 272 Pfam PF01255 Putative undecaprenyl diphosphate synthase 47 266 2.8E-67 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 Gene3D G3DSA:1.10.630.10 11 400 3.2E-134 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00385 P450 superfamily signature 340 349 6.3E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00385 P450 superfamily signature 272 283 6.3E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00385 P450 superfamily signature 349 360 6.3E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00385 P450 superfamily signature 237 254 6.3E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 Pfam PF00067 Cytochrome P450 47 370 2.4E-33 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 342 351 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 89 100 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 136 152 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 153 168 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 340 349 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 191 213 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 319 334 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 291 318 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 272 283 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 PRINTS PR00359 B-class P450 signature 349 360 3.1E-62 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46795 85d7a78badb1d2cc3aca81c28385c72c 400 SUPERFAMILY SSF48264 13 400 2.49E-103 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS31250 7c7cd369e6efc474526ffaec1306d5cb 127 TIGRFAM TIGR00060 L18_bact: ribosomal protein uL18 16 127 3.0E-38 T 17-03-2017 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31250 7c7cd369e6efc474526ffaec1306d5cb 127 Hamap MF_01337_B 50S ribosomal protein L18 [rplR]. 13 127 26.717 T 17-03-2017 IPR004389 Ribosomal protein L18, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31250 7c7cd369e6efc474526ffaec1306d5cb 127 SUPERFAMILY SSF53137 14 125 3.05E-46 T 17-03-2017 SHXM_RS31250 7c7cd369e6efc474526ffaec1306d5cb 127 Pfam PF00861 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast 13 127 6.7E-48 T 17-03-2017 IPR005484 Ribosomal protein L18 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31250 7c7cd369e6efc474526ffaec1306d5cb 127 Gene3D G3DSA:3.30.420.100 32 127 4.5E-38 T 17-03-2017 SHXM_RS20420 6b6aec9dcfc0185a9cf01bb0bbd55ac2 570 SMART SM00481 86 161 2.9E-9 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS20420 6b6aec9dcfc0185a9cf01bb0bbd55ac2 570 SUPERFAMILY SSF89550 313 333 1.04E-19 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS20420 6b6aec9dcfc0185a9cf01bb0bbd55ac2 570 SUPERFAMILY SSF89550 83 170 1.04E-19 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS20420 6b6aec9dcfc0185a9cf01bb0bbd55ac2 570 SUPERFAMILY SSF89550 203 262 1.04E-19 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS20420 6b6aec9dcfc0185a9cf01bb0bbd55ac2 570 SUPERFAMILY SSF89550 369 402 1.04E-19 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS20420 6b6aec9dcfc0185a9cf01bb0bbd55ac2 570 Gene3D G3DSA:3.20.20.140 84 189 1.4E-15 T 17-03-2017 SHXM_RS10260 192c761ddbd034865713cb451ebcba5f 260 SUPERFAMILY SSF51430 14 255 7.99E-57 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS10260 192c761ddbd034865713cb451ebcba5f 260 Pfam PF00248 Aldo/keto reductase family 19 220 4.3E-44 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS10260 192c761ddbd034865713cb451ebcba5f 260 Gene3D G3DSA:3.20.20.100 224 255 4.2E-4 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS10260 192c761ddbd034865713cb451ebcba5f 260 Gene3D G3DSA:3.20.20.100 14 218 2.3E-49 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS05770 34744f3b7518a4fcc902263983544715 290 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 39 179 3.1E-15 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS05770 34744f3b7518a4fcc902263983544715 290 Gene3D G3DSA:3.40.80.10 26 194 5.9E-17 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS05770 34744f3b7518a4fcc902263983544715 290 SMART SM00644 27 180 1.4E-19 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS05770 34744f3b7518a4fcc902263983544715 290 SUPERFAMILY SSF55846 20 194 6.48E-24 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 Gene3D G3DSA:3.50.50.60 3 125 1.4E-114 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 Gene3D G3DSA:3.50.50.60 186 313 1.4E-114 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 Gene3D G3DSA:3.50.50.60 441 505 1.4E-114 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 Pfam PF00732 GMC oxidoreductase 5 295 2.2E-85 T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 ProSitePatterns PS00623 GMC oxidoreductases signature 1. 81 104 - T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 ProSitePatterns PS00624 GMC oxidoreductases signature 2. 254 268 - T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 Pfam PF05199 GMC oxidoreductase 362 498 7.0E-40 T 17-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 SUPERFAMILY SSF51905 4 288 2.2E-80 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 SUPERFAMILY SSF51905 447 505 2.2E-80 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS45045 a90469ff17919cf16f2304b49ac1a4ae 506 SUPERFAMILY SSF54373 290 448 7.65E-41 T 17-03-2017 SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 SUPERFAMILY SSF51735 3 236 2.45E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 144 172 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 Pfam PF00106 short chain dehydrogenase 8 198 5.2E-52 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 8.7E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 8.7E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 8.7E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 1.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 1.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 1.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 1.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 206 226 1.0E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 Gene3D G3DSA:3.40.50.720 5 235 9.6E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41305 5e408e3089b77bd54b8a3cc99ad4faf9 265 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 189 1.4E-4 T 17-03-2017 SHXM_RS47375 dd962fa56f14912d8842a0112d4dd933 126 Gene3D G3DSA:3.40.30.10 19 123 1.2E-18 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS47375 dd962fa56f14912d8842a0112d4dd933 126 SUPERFAMILY SSF52833 19 123 1.15E-16 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS47375 dd962fa56f14912d8842a0112d4dd933 126 Pfam PF00578 AhpC/TSA family 19 105 6.4E-12 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS45015 3365ff76098940d3acd2e2baa9e23772 251 Gene3D G3DSA:3.60.20.10 1 244 1.4E-44 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS45015 3365ff76098940d3acd2e2baa9e23772 251 Pfam PF13522 Glutamine amidotransferase domain 71 217 9.9E-19 T 17-03-2017 SHXM_RS45015 3365ff76098940d3acd2e2baa9e23772 251 TIGRFAM TIGR03442 TIGR03442: ergothioneine biosynthesis protein EgtC 1 246 6.3E-91 T 17-03-2017 IPR017808 Ergothioneine biosynthesis protein EgtC GO:0052699 SHXM_RS45015 3365ff76098940d3acd2e2baa9e23772 251 SUPERFAMILY SSF56235 2 243 1.33E-20 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS45015 3365ff76098940d3acd2e2baa9e23772 251 Hamap MF_02036 Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase [egtC]. 1 246 40.225 T 17-03-2017 IPR032889 Gamma-glutamyl-hercynylcysteine sulfoxide hydrolase, Actinobacteria GO:0016811|GO:0052699 KEGG: 00311+3.5.1.11|KEGG: 00340+3.5.1.118|MetaCyc: PWY-7255 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SUPERFAMILY SSF55785 137 262 2.27E-18 T 17-03-2017 IPR000014 PAS domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Gene3D G3DSA:3.40.50.2300 1385 1505 1.3E-9 T 17-03-2017 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SUPERFAMILY SSF52172 1384 1478 5.12E-11 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SUPERFAMILY SSF55785 10 108 4.71E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Gene3D G3DSA:3.30.565.10 392 509 3.1E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SUPERFAMILY SSF47384 328 413 4.32E-7 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 10 113 2.3E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 151 262 4.3E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Gene3D G3DSA:3.30.450.20 10 111 7.1E-13 T 17-03-2017 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Gene3D G3DSA:3.30.450.20 142 262 1.3E-23 T 17-03-2017 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Pfam PF00072 Response regulator receiver domain 1389 1470 5.3E-5 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SUPERFAMILY SSF55874 402 548 1.84E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Pfam PF00989 PAS fold 151 262 1.1E-14 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SMART SM00448 1387 1501 0.0089 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 Pfam PF08448 PAS fold 16 110 5.3E-5 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SMART SM00091 10 76 1.5E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS27540 5a3af89e3f439e7a473f7bc114001f37 1511 SMART SM00091 147 213 5.1E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS13410 cee902ba1f153406ab9e8963d306187d 311 Pfam PF01061 ABC-2 type transporter 60 269 2.6E-18 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS28875 dd9ca01e2be55da25444cf9dd3492c38 213 Gene3D G3DSA:2.60.40.360 98 191 2.1E-4 T 17-03-2017 IPR008962 PapD-like SHXM_RS28875 dd9ca01e2be55da25444cf9dd3492c38 213 Pfam PF14016 Protein of unknown function (DUF4232) 87 209 2.6E-23 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS02175 18ad66484f204b90d56b99d1d7746766 334 TIGRFAM TIGR03945 PLP_SbnA_fam: 2,3-diaminopropionate biosynthesis protein SbnA 7 306 1.9E-121 T 17-03-2017 IPR023927 2,3-diaminopropionate biosynthesis protein SbnA SHXM_RS02175 18ad66484f204b90d56b99d1d7746766 334 SUPERFAMILY SSF53686 22 310 9.82E-75 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS02175 18ad66484f204b90d56b99d1d7746766 334 Gene3D G3DSA:3.40.50.1100 138 308 5.7E-47 T 17-03-2017 SHXM_RS02175 18ad66484f204b90d56b99d1d7746766 334 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 24 290 1.8E-53 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS02175 18ad66484f204b90d56b99d1d7746766 334 Gene3D G3DSA:3.40.50.1100 34 137 7.2E-26 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 SUPERFAMILY SSF51905 7 342 1.3E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 14 334 6.3E-55 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 Gene3D G3DSA:3.50.50.60 10 122 2.6E-23 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 174 199 2.0E-11 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 271 285 2.0E-11 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 310 317 2.0E-11 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 14 36 2.0E-11 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 15 34 6.3E-21 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 174 192 6.3E-21 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 118 136 6.3E-21 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 295 317 6.3E-21 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 270 286 6.3E-21 T 17-03-2017 SHXM_RS20715 e4f8792b66529e00e57f6b60ebe011d3 473 Gene3D G3DSA:3.50.50.60 123 341 1.8E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12785 c6dbb70f5e034fde4739b0560b83f414 272 Pfam PF00588 SpoU rRNA Methylase family 122 263 1.9E-33 T 17-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SHXM_RS12785 c6dbb70f5e034fde4739b0560b83f414 272 Gene3D G3DSA:3.40.1280.10 116 266 5.5E-51 T 17-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SHXM_RS12785 c6dbb70f5e034fde4739b0560b83f414 272 SUPERFAMILY SSF75217 114 266 3.14E-37 T 17-03-2017 IPR029028 Alpha/beta knot methyltransferases SHXM_RS12785 c6dbb70f5e034fde4739b0560b83f414 272 Gene3D G3DSA:3.30.1330.30 7 105 5.6E-16 T 17-03-2017 IPR029064 50S ribosomal protein L30e-like SHXM_RS12785 c6dbb70f5e034fde4739b0560b83f414 272 SUPERFAMILY SSF55315 6 106 5.41E-16 T 17-03-2017 IPR029064 50S ribosomal protein L30e-like SHXM_RS15595 3263b98b1ca4b1991a6aa50c19e351e7 190 SUPERFAMILY SSF54593 9 161 5.09E-20 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS15595 3263b98b1ca4b1991a6aa50c19e351e7 190 Gene3D G3DSA:3.10.180.10 10 159 3.8E-28 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS15595 3263b98b1ca4b1991a6aa50c19e351e7 190 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 15 126 7.9E-12 T 17-03-2017 SHXM_RS29435 188ed25c7a92e6d4ba082823037fd3ee 68 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 11 58 1.2E-8 T 17-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 SHXM_RS29435 188ed25c7a92e6d4ba082823037fd3ee 68 SUPERFAMILY SSF46955 11 59 2.61E-11 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS29435 188ed25c7a92e6d4ba082823037fd3ee 68 Pfam PF12728 Helix-turn-helix domain 11 59 1.3E-11 T 17-03-2017 SHXM_RS29435 188ed25c7a92e6d4ba082823037fd3ee 68 Gene3D G3DSA:1.10.1660.10 11 57 5.4E-7 T 17-03-2017 SHXM_RS07055 89f3d82e44f4ec965ee76bc0d2828a3a 247 Pfam PF14451 Mut7-C ubiquitin 4 82 1.3E-23 T 17-03-2017 IPR027798 Ubiquitin Mut7-C domain SHXM_RS07055 89f3d82e44f4ec965ee76bc0d2828a3a 247 Pfam PF01927 Mut7-C RNAse domain 90 231 2.7E-41 T 17-03-2017 IPR002782 Mut7-C RNAse domain SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 SUPERFAMILY SSF88946 69 156 7.46E-13 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 69 224 8.6E-49 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 Pfam PF04542 Sigma-70 region 2 76 141 3.3E-10 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 Gene3D G3DSA:1.10.1740.10 69 143 2.0E-13 T 17-03-2017 SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 SUPERFAMILY SSF88659 167 224 3.05E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 Gene3D G3DSA:1.10.10.10 169 225 2.1E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 Pfam PF08281 Sigma-70, region 4 170 220 1.3E-12 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS17565 094810d509db39d9fcad9cef0fecf6fd 273 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 72 223 6.8E-15 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 Gene3D G3DSA:3.40.50.720 5 226 5.0E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 11 225 1.6E-34 T 17-03-2017 SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 67 78 1.1E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 118 126 1.1E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 156 1.1E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 1.2E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 175 1.2E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 112 128 1.2E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 137 156 1.2E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 189 209 1.2E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 67 78 1.2E-30 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 5 172 0.0021 T 17-03-2017 SHXM_RS08200 c4b94a8e35f0b44a5e9c313414b4ddaa 227 SUPERFAMILY SSF51735 4 226 7.17E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36210 4fbbb06fec198a2035d32e3996e96cb7 215 SUPERFAMILY SSF46689 11 82 3.28E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS36210 4fbbb06fec198a2035d32e3996e96cb7 215 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 61 3.4E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36210 4fbbb06fec198a2035d32e3996e96cb7 215 Gene3D G3DSA:1.10.357.10 12 200 6.2E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS36210 4fbbb06fec198a2035d32e3996e96cb7 215 SUPERFAMILY SSF48498 92 198 2.99E-5 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 SUPERFAMILY SSF50331 238 342 3.0E-8 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 Gene3D G3DSA:3.40.50.300 3 233 1.7E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 ProSitePatterns PS00211 ABC transporters family signature. 134 148 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 Pfam PF00005 ABC transporter 19 161 3.0E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 SMART SM00382 28 211 1.6E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 SUPERFAMILY SSF52540 3 241 1.97E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36695 cc757157648b7dc06c31fd7e63cd8575 345 Pfam PF08402 TOBE domain 269 341 1.4E-8 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS05725 4877f1e6bb800ba6bec5504cfe69502a 216 Gene3D G3DSA:3.40.50.720 3 212 5.4E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05725 4877f1e6bb800ba6bec5504cfe69502a 216 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 4 95 9.1E-13 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS05725 4877f1e6bb800ba6bec5504cfe69502a 216 SUPERFAMILY SSF51735 4 210 2.54E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 SMART SM00387 309 410 1.7E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 SMART SM00388 202 267 9.3E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 SUPERFAMILY SSF55874 270 398 1.19E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 Gene3D G3DSA:3.30.565.10 272 395 8.2E-24 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 SUPERFAMILY SSF47384 186 263 5.49E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 Pfam PF00672 HAMP domain 130 196 8.8E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 Pfam PF00512 His Kinase A (phospho-acceptor) domain 203 263 3.0E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 Gene3D G3DSA:1.10.287.130 193 263 1.4E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 313 394 1.2E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 PRINTS PR00344 Bacterial sensor protein C-terminal signature 344 358 2.7E-7 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24325 8e1c92e886beb60100714aded792ebbb 416 PRINTS PR00344 Bacterial sensor protein C-terminal signature 372 390 2.7E-7 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 362 462 2.8E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 SMART SM00388 246 317 4.3E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 SUPERFAMILY SSF47384 229 315 1.45E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 SUPERFAMILY SSF55874 307 463 4.32E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 SMART SM00387 359 465 1.2E-31 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 Pfam PF00512 His Kinase A (phospho-acceptor) domain 247 316 4.3E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 Gene3D G3DSA:3.30.565.10 326 467 1.3E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 410 420 4.9E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 392 406 4.9E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 425 443 4.9E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 PRINTS PR00344 Bacterial sensor protein C-terminal signature 449 462 4.9E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 Pfam PF00672 HAMP domain 173 240 9.0E-15 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 Gene3D G3DSA:1.10.287.130 237 313 1.9E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 SUPERFAMILY SSF158472 195 242 5.62E-7 T 17-03-2017 SHXM_RS30150 8632949d28614f941bd7fb98025fa8c7 474 SMART SM00304 192 245 2.3E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 SUPERFAMILY SSF52518 27 206 2.18E-9 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 457 545 1.1E-6 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 SUPERFAMILY SSF52518 437 621 3.16E-14 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 SUPERFAMILY SSF53323 723 926 1.11E-21 T 17-03-2017 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 SUPERFAMILY SSF52922 286 373 4.32E-5 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 Gene3D G3DSA:3.40.920.10 724 921 1.2E-17 T 17-03-2017 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 Pfam PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase 731 917 8.0E-24 T 17-03-2017 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 SHXM_RS32145 929c837b531b189fafdcbb611dfa4d70 1173 Gene3D G3DSA:3.40.50.970 429 648 1.5E-8 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 181 0.0098 T 17-03-2017 SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 SUPERFAMILY SSF51735 2 215 8.31E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 Pfam PF00106 short chain dehydrogenase 7 192 2.8E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 1.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 1.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 1.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 168 1.7E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 Gene3D G3DSA:3.40.50.720 5 224 5.5E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39500 bba46cafb70636a9102b860416282b6e 253 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 136 164 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS43940 a105795511dd73cfbd51a79bc95f5978 250 Pfam PF00376 MerR family regulatory protein 22 63 3.2E-11 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43940 a105795511dd73cfbd51a79bc95f5978 250 SUPERFAMILY SSF46955 36 99 6.87E-13 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS43940 a105795511dd73cfbd51a79bc95f5978 250 Gene3D G3DSA:1.10.1660.10 22 100 6.2E-18 T 17-03-2017 SHXM_RS43940 a105795511dd73cfbd51a79bc95f5978 250 SMART SM00422 21 95 2.0E-17 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS20870 6794432521694565304475e99d7dc5de 271 SUPERFAMILY SSF161098 3 268 1.4E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20870 6794432521694565304475e99d7dc5de 271 Gene3D G3DSA:1.10.3720.10 2 258 2.3E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20870 6794432521694565304475e99d7dc5de 271 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 91 264 1.0E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 PRINTS PR01438 Universal stress protein signature 99 111 4.4E-11 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 PRINTS PR01438 Universal stress protein signature 2 20 4.4E-11 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 PRINTS PR01438 Universal stress protein signature 117 139 4.4E-11 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 Gene3D G3DSA:3.40.50.620 145 289 1.1E-20 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 Gene3D G3DSA:3.40.50.620 5 139 2.6E-29 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 SUPERFAMILY SSF52402 149 290 5.02E-17 T 17-03-2017 SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 SUPERFAMILY SSF52402 5 142 4.02E-27 T 17-03-2017 SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 Pfam PF00582 Universal stress protein family 150 289 8.0E-15 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS07985 e9385e46a87177282b7f7f0788e4e1ef 292 Pfam PF00582 Universal stress protein family 5 139 4.6E-24 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 Pfam PF07478 D-ala D-ala ligase C-terminus 156 332 4.9E-32 T 17-03-2017 IPR011095 D-alanine--D-alanine ligase, C-terminal GO:0008716 KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 ProSitePatterns PS00843 D-alanine--D-alanine ligase signature 1. 96 107 - T 17-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 Gene3D G3DSA:3.30.470.20 207 336 1.4E-29 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 Gene3D G3DSA:3.30.470.20 119 142 1.4E-29 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 ProSitePatterns PS00844 D-alanine--D-alanine ligase signature 2. 278 306 - T 17-03-2017 IPR000291 D-alanine--D-alanine ligase/VANA/B/C, conserved site KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 SUPERFAMILY SSF56059 129 331 9.43E-38 T 17-03-2017 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 Gene3D G3DSA:3.30.1490.20 143 205 1.5E-12 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 Gene3D G3DSA:3.40.50.20 87 118 2.2E-9 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 SUPERFAMILY SSF52440 31 129 7.58E-15 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS32225 674214552b9d3226f39e2d0d2e6fe40f 363 Pfam PF01820 D-ala D-ala ligase N-terminus 74 119 1.3E-9 T 17-03-2017 IPR011127 D-alanine--D-alanine ligase, N-terminal domain KEGG: 00473+6.3.2.4|KEGG: 00550+6.3.2.4|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS11040 f809e0a8fe0b32980f7e1d2889843272 353 Pfam PF00877 NlpC/P60 family 217 308 2.1E-5 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS11040 f809e0a8fe0b32980f7e1d2889843272 353 SUPERFAMILY SSF54001 192 324 1.41E-10 T 17-03-2017 SHXM_RS11040 f809e0a8fe0b32980f7e1d2889843272 353 Gene3D G3DSA:3.90.1720.10 193 353 8.8E-16 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS24365 518e60a924457a9aa8f5f16e37cd8dcc 122 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 14 117 5.4E-26 T 17-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 SHXM_RS24365 518e60a924457a9aa8f5f16e37cd8dcc 122 Gene3D G3DSA:3.30.750.24 14 120 2.0E-34 T 17-03-2017 IPR002645 STAS domain SHXM_RS24365 518e60a924457a9aa8f5f16e37cd8dcc 122 SUPERFAMILY SSF52091 14 120 1.41E-25 T 17-03-2017 IPR002645 STAS domain SHXM_RS24365 518e60a924457a9aa8f5f16e37cd8dcc 122 Pfam PF13466 STAS domain 30 106 6.9E-16 T 17-03-2017 IPR002645 STAS domain SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 Gene3D G3DSA:3.90.25.10 313 342 3.5E-4 T 17-03-2017 SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 Gene3D G3DSA:3.90.25.10 184 201 3.5E-4 T 17-03-2017 SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 222 9.3E-32 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 Gene3D G3DSA:3.40.50.720 1 160 8.8E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 Gene3D G3DSA:3.40.50.720 202 241 8.8E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 SUPERFAMILY SSF51735 314 343 3.9E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34240 2141593f389ddcc593b189cd30f33a2b 350 SUPERFAMILY SSF51735 1 256 3.9E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15305 fbd05169b8fb4855bec9db99f6745223 397 Pfam PF00155 Aminotransferase class I and II 38 380 1.0E-61 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS15305 fbd05169b8fb4855bec9db99f6745223 397 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 241 254 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS15305 fbd05169b8fb4855bec9db99f6745223 397 Gene3D G3DSA:3.40.640.10 53 263 3.9E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS15305 fbd05169b8fb4855bec9db99f6745223 397 SUPERFAMILY SSF53383 11 392 1.48E-109 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS15305 fbd05169b8fb4855bec9db99f6745223 397 Gene3D G3DSA:3.90.1150.10 264 393 1.0E-30 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 PRINTS PR00094 Adenylate kinase signature 4 17 2.2E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 PRINTS PR00094 Adenylate kinase signature 81 97 2.2E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 PRINTS PR00094 Adenylate kinase signature 178 192 2.2E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 PRINTS PR00094 Adenylate kinase signature 161 176 2.2E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 PRINTS PR00094 Adenylate kinase signature 32 46 2.2E-36 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 SUPERFAMILY SSF52540 1 215 1.21E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 Hamap MF_00235 Adenylate kinase [adk]. 1 214 50.546 T 17-03-2017 IPR000850 Adenylate kinase/UMP-CMP kinase GO:0005524|GO:0006139|GO:0019205 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219|Reactome: R-HSA-499943 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 TIGRFAM TIGR01351 adk: adenylate kinase 2 213 1.9E-77 T 17-03-2017 IPR006259 Adenylate kinase subfamily GO:0004017|GO:0005524|GO:0016776 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 Pfam PF00406 Adenylate kinase 5 191 2.4E-59 T 17-03-2017 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 Pfam PF05191 Adenylate kinase, active site lid 127 163 2.1E-12 T 17-03-2017 IPR007862 Adenylate kinase, active site lid domain GO:0004017 KEGG: 00230+2.7.4.3|MetaCyc: PWY-7219 SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 Gene3D G3DSA:3.40.50.300 1 212 1.1E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48855 5a4691919c333c7c28f7fb22f7e1a8a8 220 ProSitePatterns PS00113 Adenylate kinase signature. 81 92 - T 17-03-2017 SHXM_RS19170 988d9473188438b16251e345ebd9daa3 450 Pfam PF07690 Major Facilitator Superfamily 262 439 1.3E-13 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS19170 988d9473188438b16251e345ebd9daa3 450 Pfam PF00083 Sugar (and other) transporter 20 229 2.5E-19 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS19170 988d9473188438b16251e345ebd9daa3 450 Gene3D G3DSA:1.20.1250.20 245 435 4.8E-20 T 17-03-2017 SHXM_RS19170 988d9473188438b16251e345ebd9daa3 450 Gene3D G3DSA:1.20.1250.20 18 226 1.5E-18 T 17-03-2017 SHXM_RS19170 988d9473188438b16251e345ebd9daa3 450 SUPERFAMILY SSF103473 8 436 1.7E-62 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14085 1160b831f4a54dc33967252ca24e3062 397 Gene3D G3DSA:3.40.50.1580 6 242 1.6E-43 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS14085 1160b831f4a54dc33967252ca24e3062 397 Pfam PF01048 Phosphorylase superfamily 6 242 5.0E-29 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS14085 1160b831f4a54dc33967252ca24e3062 397 SUPERFAMILY SSF53167 6 248 4.19E-40 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 ProSitePatterns PS00094 C-5 cytosine-specific DNA methylases active site. 82 94 - T 17-03-2017 IPR018117 DNA methylase, C-5 cytosine-specific, active site KEGG: 00270+2.1.1.37|Reactome: R-HSA-212300|Reactome: R-HSA-5334118 SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 Gene3D G3DSA:3.40.50.150 178 204 4.8E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 Gene3D G3DSA:3.40.50.150 14 135 4.8E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 13 29 2.0E-14 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 120 134 2.0E-14 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 196 209 2.0E-14 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 Pfam PF00145 C-5 cytosine-specific DNA methylase 181 415 4.4E-23 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 Pfam PF00145 C-5 cytosine-specific DNA methylase 13 149 1.7E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 SUPERFAMILY SSF53335 281 419 1.74E-64 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 SUPERFAMILY SSF53335 14 148 1.74E-64 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 SUPERFAMILY SSF53335 179 229 1.74E-64 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 Gene3D G3DSA:3.90.120.10 280 407 1.3E-24 T 17-03-2017 SHXM_RS35080 e513b1780a8dbeca79ed26be8603a13e 430 Gene3D G3DSA:3.90.120.10 205 222 1.3E-24 T 17-03-2017 SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 SUPERFAMILY SSF53383 8 405 1.41E-115 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 229 266 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 Gene3D G3DSA:3.40.640.10 63 310 5.2E-83 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 TIGRFAM TIGR01885 Orn_aminotrans: ornithine--oxo-acid transaminase 8 404 4.0E-143 T 17-03-2017 IPR010164 Ornithine aminotransferase GO:0008483|GO:0030170 KEGG: 00330+2.6.1.13|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 Gene3D G3DSA:3.90.1150.10 314 406 1.4E-33 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 Gene3D G3DSA:3.90.1150.10 8 61 1.4E-33 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS25170 c7d478f8999eeb14960f8a2bbb94656d 406 Pfam PF00202 Aminotransferase class-III 19 404 1.4E-109 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 SUPERFAMILY SSF63737 5 207 4.18E-40 T 17-03-2017 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 SUPERFAMILY SSF55486 226 470 1.22E-73 T 17-03-2017 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 Pfam PF11838 ERAP1-like C-terminal domain 548 859 1.3E-59 T 17-03-2017 IPR024571 ERAP1-like C-terminal domain SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 Gene3D G3DSA:1.10.390.10 325 472 2.4E-40 T 17-03-2017 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 TIGRFAM TIGR02412 pepN_strep_liv: aminopeptidase N 5 865 0.0 T 17-03-2017 IPR012778 Peptidase M1, aminopeptidase GO:0004177|GO:0006508 KEGG: 00480+3.4.11.2|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 Pfam PF01433 Peptidase family M1 36 404 4.1E-65 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 140 155 1.1E-16 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 312 327 1.1E-16 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 331 343 1.1E-16 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 190 205 1.1E-16 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS21830 db77fb35b5f30b05b72ed214980b3901 872 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 278 288 1.1E-16 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS29790 0de99d700921af059e329ccd9e64f102 507 Pfam PF13367 Protease prsW family 73 278 1.2E-52 T 17-03-2017 IPR026898 Protease PrsW GO:0008233 SHXM_RS46635 8ac3ec8fb2c8adfdac99dca43553f178 297 Gene3D G3DSA:1.10.10.60 228 270 3.4E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46635 8ac3ec8fb2c8adfdac99dca43553f178 297 Pfam PF12833 Helix-turn-helix domain 195 270 6.9E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46635 8ac3ec8fb2c8adfdac99dca43553f178 297 SMART SM00342 189 271 1.5E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46635 8ac3ec8fb2c8adfdac99dca43553f178 297 Gene3D G3DSA:1.10.10.60 188 227 2.7E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46635 8ac3ec8fb2c8adfdac99dca43553f178 297 SUPERFAMILY SSF46689 228 271 1.16E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 Pfam PF01471 Putative peptidoglycan binding domain 228 279 3.2E-9 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 Gene3D G3DSA:1.10.530.10 332 394 4.9E-4 T 17-03-2017 SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 SUPERFAMILY SSF53955 302 393 7.41E-7 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 Pfam PF13560 Helix-turn-helix domain 9 72 1.1E-9 T 17-03-2017 SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 Gene3D G3DSA:1.10.260.40 12 86 1.1E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 Gene3D G3DSA:1.10.101.10 220 282 1.2E-13 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 SUPERFAMILY SSF47413 12 88 1.54E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38760 9a5ba15d13c5770cfb496ae9eb9c7553 410 SUPERFAMILY SSF47090 217 280 6.8E-13 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 Pfam PF00890 FAD binding domain 5 422 2.9E-29 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 Gene3D G3DSA:3.50.50.60 2 212 1.2E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 Gene3D G3DSA:3.50.50.60 381 439 1.2E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 SUPERFAMILY SSF56425 229 380 5.58E-17 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 161 170 6.6E-6 T 17-03-2017 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 5 27 6.6E-6 T 17-03-2017 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 SUPERFAMILY SSF51905 2 215 1.22E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 SUPERFAMILY SSF51905 378 437 1.22E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10740 4d47fd7eb5ea66983e2e4b624efc79ca 453 Gene3D G3DSA:3.90.700.10 240 376 1.4E-13 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS24660 2943fdcfcab5f07a894cf156c5b0a106 264 Pfam PF00378 Enoyl-CoA hydratase/isomerase 18 262 2.8E-57 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS24660 2943fdcfcab5f07a894cf156c5b0a106 264 SUPERFAMILY SSF52096 8 263 2.78E-79 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS24660 2943fdcfcab5f07a894cf156c5b0a106 264 Gene3D G3DSA:1.10.12.10 205 264 1.2E-17 T 17-03-2017 IPR014748 Crontonase, C-terminal SHXM_RS24660 2943fdcfcab5f07a894cf156c5b0a106 264 Gene3D G3DSA:3.90.226.10 10 204 3.1E-64 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS24660 2943fdcfcab5f07a894cf156c5b0a106 264 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 105 125 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 SUPERFAMILY SSF46689 212 256 1.46E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 Gene3D G3DSA:1.10.10.60 261 308 6.9E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 SUPERFAMILY SSF52317 4 188 6.87E-45 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 Gene3D G3DSA:3.40.50.880 5 201 3.2E-50 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 SMART SM00342 222 305 1.0E-27 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 Gene3D G3DSA:1.10.10.60 215 260 9.0E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 Pfam PF01965 DJ-1/PfpI family 4 167 1.3E-19 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 Pfam PF12833 Helix-turn-helix domain 228 306 2.2E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 SUPERFAMILY SSF46689 259 308 1.59E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10550 9b477c5430b732e4238e632c39b7756a 326 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 259 301 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 Gene3D G3DSA:3.40.1010.10 165 279 4.9E-41 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 Gene3D G3DSA:3.40.50.720 7 113 6.3E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12790 28d1e97118ff5593201c275823103883 406 SUPERFAMILY SSF51735 7 110 1.0E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12790 28d1e97118ff5593201c275823103883 406 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 165 377 2.7E-48 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 SUPERFAMILY SSF53790 163 401 3.53E-73 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 TIGRFAM TIGR01469 cobA_cysG_Cterm: uroporphyrinogen-III C-methyltransferase 165 401 1.2E-83 T 17-03-2017 IPR006366 Uroporphyrin-III C-methyltransferase GO:0006779|GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 Gene3D G3DSA:3.30.950.10 280 402 8.6E-44 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 Pfam PF13241 Putative NAD(P)-binding 11 118 2.3E-19 T 17-03-2017 IPR006367 Sirohaem synthase, N-terminal GO:0006779|GO:0019354|GO:0043115|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 TIGRFAM TIGR01470 cysG_Nterm: siroheme synthase, N-terminal domain 8 132 1.2E-19 T 17-03-2017 IPR006367 Sirohaem synthase, N-terminal GO:0006779|GO:0019354|GO:0043115|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS12790 28d1e97118ff5593201c275823103883 406 ProSitePatterns PS00840 Uroporphyrin-III C-methyltransferase signature 2. 244 277 - T 17-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 SUPERFAMILY SSF50249 1 67 3.0E-25 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 Gene3D G3DSA:2.40.50.140 1 66 2.0E-30 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 PIRSF PIRSF002599 1 68 1.1E-25 T 17-03-2017 IPR012156 Cold shock, CspA GO:0003676 SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 Pfam PF00313 'Cold-shock' DNA-binding domain 3 65 5.3E-30 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 PRINTS PR00050 Cold shock protein signature 40 58 2.8E-17 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 PRINTS PR00050 Cold shock protein signature 25 34 2.8E-17 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 PRINTS PR00050 Cold shock protein signature 4 19 2.8E-17 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS23705 6a8c4e72dff96d17ac8203aa663dcb2a 69 SMART SM00357 3 67 6.4E-30 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS22860 52b3e4df5aa0b197911977a667c76598 427 Pfam PF13245 Part of AAA domain 5 71 2.4E-11 T 17-03-2017 SHXM_RS22860 52b3e4df5aa0b197911977a667c76598 427 Gene3D G3DSA:3.40.50.300 10 211 4.6E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22860 52b3e4df5aa0b197911977a667c76598 427 SUPERFAMILY SSF52540 11 236 3.09E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22860 52b3e4df5aa0b197911977a667c76598 427 SUPERFAMILY SSF52540 267 379 3.09E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 SMART SM00895 95 218 1.2E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 Pfam PF00392 Bacterial regulatory proteins, gntR family 11 74 2.2E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 Pfam PF07729 FCD domain 97 215 5.1E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 SMART SM00345 15 74 5.9E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 SUPERFAMILY SSF48008 92 215 6.28E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 Gene3D G3DSA:1.10.10.10 8 77 2.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 SUPERFAMILY SSF46785 7 78 2.41E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 Gene3D G3DSA:1.20.120.530 90 215 3.1E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 34 48 5.1E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17295 70c4d274bb307def9801ba2ae87fcdb8 224 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 48 64 5.1E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS28755 7dcef1848c25ca49dfab4d6bd21f9271 284 TIGRFAM TIGR02141 modB_ABC: molybdate ABC transporter, permease protein 74 277 1.0E-73 T 17-03-2017 IPR011867 Molybdate ABC transporter, permease protein GO:0015098|GO:0015689|GO:0016021 SHXM_RS28755 7dcef1848c25ca49dfab4d6bd21f9271 284 TIGRFAM TIGR01581 Mo_ABC_porter: NifC-like ABC-type porter 52 271 1.8E-75 T 17-03-2017 IPR006469 NifC-like ABC-type porter GO:0005215|GO:0006810|GO:0016020 SHXM_RS28755 7dcef1848c25ca49dfab4d6bd21f9271 284 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 91 281 6.7E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS28755 7dcef1848c25ca49dfab4d6bd21f9271 284 SUPERFAMILY SSF161098 31 275 2.88E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS28755 7dcef1848c25ca49dfab4d6bd21f9271 284 Gene3D G3DSA:1.10.3720.10 36 275 7.3E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34655 9f87c0ad50590f6c4c8280d7ca437e4e 192 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 35 175 9.9E-16 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS34655 9f87c0ad50590f6c4c8280d7ca437e4e 192 SMART SM00644 23 176 3.0E-24 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS34655 9f87c0ad50590f6c4c8280d7ca437e4e 192 Gene3D G3DSA:3.40.80.10 22 189 1.7E-16 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS34655 9f87c0ad50590f6c4c8280d7ca437e4e 192 SUPERFAMILY SSF55846 14 188 4.32E-25 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 Gene3D G3DSA:3.40.190.10 146 249 3.1E-22 T 17-03-2017 SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 SUPERFAMILY SSF53850 55 283 9.61E-55 T 17-03-2017 SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 SUPERFAMILY SSF53850 7 24 9.61E-55 T 17-03-2017 SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 88 101 - T 17-03-2017 IPR018313 Solute-binding protein family 3, conserved site GO:0005215|GO:0006810 SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 66 283 7.3E-46 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 SMART SM00062 65 289 2.8E-49 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 Gene3D G3DSA:3.40.190.10 62 145 2.1E-29 T 17-03-2017 SHXM_RS37275 d07363147bb3c3efd26a8608ee6790c6 303 Gene3D G3DSA:3.40.190.10 250 283 2.1E-29 T 17-03-2017 SHXM_RS10225 ac945a350883c344492d0e516689ab1c 309 SUPERFAMILY SSF46785 63 131 2.87E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10225 ac945a350883c344492d0e516689ab1c 309 SUPERFAMILY SSF55781 139 284 2.81E-7 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS10225 ac945a350883c344492d0e516689ab1c 309 SMART SM00346 62 148 2.0E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS10225 ac945a350883c344492d0e516689ab1c 309 Gene3D G3DSA:3.30.450.40 132 285 4.9E-8 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS10225 ac945a350883c344492d0e516689ab1c 309 Pfam PF09339 IclR helix-turn-helix domain 66 112 2.7E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS10225 ac945a350883c344492d0e516689ab1c 309 Gene3D G3DSA:1.10.10.10 60 128 2.6E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45885 24d7e8ff0421220a0bdfba8f39879571 309 Pfam PF01435 Peptidase family M48 125 183 5.2E-11 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS45885 24d7e8ff0421220a0bdfba8f39879571 309 Gene3D G3DSA:3.30.2010.10 118 180 6.4E-14 T 17-03-2017 SHXM_RS23335 f6d252d414a2bbe5744e215127681ebe 326 Pfam PF00005 ABC transporter 34 177 1.3E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS23335 f6d252d414a2bbe5744e215127681ebe 326 SUPERFAMILY SSF52540 28 244 1.25E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23335 f6d252d414a2bbe5744e215127681ebe 326 Gene3D G3DSA:3.40.50.300 2 247 1.7E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23335 f6d252d414a2bbe5744e215127681ebe 326 SMART SM00382 42 227 5.7E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS06145 70710931e7dc33fc364952d69f6b23de 171 Gene3D G3DSA:1.20.120.450 2 171 4.1E-52 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS06145 70710931e7dc33fc364952d69f6b23de 171 Pfam PF04978 Protein of unknown function (DUF664) 22 167 1.5E-51 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS06145 70710931e7dc33fc364952d69f6b23de 171 SUPERFAMILY SSF109854 1 166 7.02E-47 T 17-03-2017 SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 SMART SM00895 97 221 5.4E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 SUPERFAMILY SSF46785 11 80 4.49E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 SMART SM00345 17 76 1.0E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 Pfam PF07729 FCD domain 97 219 1.4E-22 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 Gene3D G3DSA:1.10.10.10 11 80 3.4E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 Gene3D G3DSA:1.20.120.530 96 222 2.1E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 7.6E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 7.6E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 SUPERFAMILY SSF48008 96 219 1.05E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS48950 2e477f535342f7d5efe64133384fa9a4 230 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 76 2.7E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00385 P450 superfamily signature 252 269 9.8E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00385 P450 superfamily signature 362 373 9.8E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00385 P450 superfamily signature 353 362 9.8E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00385 P450 superfamily signature 282 293 9.8E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 355 364 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 109 120 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 172 187 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 300 327 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 155 171 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 282 293 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 353 362 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 211 233 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 362 373 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 PRINTS PR00359 B-class P450 signature 328 343 1.4E-50 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 Pfam PF00067 Cytochrome P450 282 380 5.0E-20 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 SUPERFAMILY SSF48264 28 413 1.96E-92 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS48560 e915a8096c2e866cdce2062225eff7a4 428 Gene3D G3DSA:1.10.630.10 25 414 5.3E-120 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS25125 35b11baa76c5a6743808a50f58690798 464 Pfam PF04892 VanZ like family 49 189 5.6E-19 T 17-03-2017 IPR006976 VanZ-like SHXM_RS25125 35b11baa76c5a6743808a50f58690798 464 Pfam PF06271 RDD family 212 381 3.4E-11 T 17-03-2017 IPR010432 RDD SHXM_RS04710 1db8d81d95624b482d94d8f04e6161fc 786 SUPERFAMILY SSF75005 45 353 1.43E-65 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS04710 1db8d81d95624b482d94d8f04e6161fc 786 Pfam PF04616 Glycosyl hydrolases family 43 46 351 5.4E-53 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS04710 1db8d81d95624b482d94d8f04e6161fc 786 SUPERFAMILY SSF49899 576 782 1.98E-15 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS04710 1db8d81d95624b482d94d8f04e6161fc 786 Gene3D G3DSA:2.115.10.20 42 358 1.2E-77 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS04710 1db8d81d95624b482d94d8f04e6161fc 786 Gene3D G3DSA:2.60.120.200 576 782 5.4E-17 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 942 1059 5.5E-38 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2100 2324 1.2E-24 T 17-03-2017 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1062 1175 8.3E-10 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF47336 1691 1787 5.92E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF51412 306 529 4.58E-13 T 17-03-2017 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF51735 2100 2138 2.55E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF51735 2184 2351 2.55E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF03060 Nitronate monooxygenase 308 565 4.9E-8 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.30.70.250 1352 1418 5.5E-15 T 17-03-2017 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.40.50.720 2184 2323 9.2E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.40.50.720 2100 2138 9.2E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.40.47.10 947 1111 2.7E-51 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF51412 27 202 1.85E-13 T 17-03-2017 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF53901 669 787 3.3E-79 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF53901 830 1055 3.3E-79 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF53901 1088 1109 3.3E-79 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF00550 Phosphopantetheine attachment site 1799 1866 6.1E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF00550 Phosphopantetheine attachment site 1697 1746 3.0E-5 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF08659 KR domain 2101 2322 7.3E-33 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.40.366.10 1220 1345 7.7E-49 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.40.366.10 1419 1521 7.7E-49 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1226 1539 3.1E-35 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF47336 1797 1903 4.48E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF00698 Acyl transferase domain 1226 1514 6.8E-33 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF52151 1222 1351 2.88E-50 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF52151 1420 1522 2.88E-50 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:3.40.47.10 672 946 2.0E-73 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:1.10.1200.10 1694 1768 7.1E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Gene3D G3DSA:1.10.1200.10 1797 1865 4.8E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF51735 1913 2069 3.54E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SMART SM00825 Beta-ketoacyl synthase 672 1112 3.7E-110 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 671 934 2.5E-70 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS40750 3388cc1cc8ff007bbed20b24fb7630ed 2377 SUPERFAMILY SSF55048 1353 1418 3.92E-14 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS11480 6f4cf68c94154235eabf74f5c8129a2e 289 SUPERFAMILY SSF49899 45 285 1.0E-71 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS11480 6f4cf68c94154235eabf74f5c8129a2e 289 Gene3D G3DSA:2.60.120.200 44 285 2.8E-77 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS11480 6f4cf68c94154235eabf74f5c8129a2e 289 Pfam PF00722 Glycosyl hydrolases family 16 76 283 5.3E-43 T 17-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 SHXM_RS04400 9d77d640bab0228663b96b8695fefd29 257 SUPERFAMILY SSF52266 22 219 3.38E-36 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS04400 9d77d640bab0228663b96b8695fefd29 257 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 35 208 5.3E-20 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS04400 9d77d640bab0228663b96b8695fefd29 257 Gene3D G3DSA:3.40.50.1110 26 218 9.6E-37 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 Hamap MF_00140_B Tryptophan--tRNA ligase [trpS]. 5 333 41.723 T 17-03-2017 IPR024109 Tryptophan-tRNA ligase, bacterial-type GO:0004830 KEGG: 00970+6.1.1.2|Reactome: R-HSA-379726 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 Gene3D G3DSA:1.10.240.10 215 307 1.3E-12 T 17-03-2017 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 19 35 7.0E-26 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 146 167 7.0E-26 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 199 209 7.0E-26 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 PRINTS PR01039 Tryptophanyl-tRNA synthetase signature 69 88 7.0E-26 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 TIGRFAM TIGR00233 trpS: tryptophan--tRNA ligase 5 332 1.2E-103 T 17-03-2017 IPR002306 Tryptophan-tRNA ligase GO:0000166|GO:0004830|GO:0005524|GO:0005737|GO:0006436 KEGG: 00970+6.1.1.2 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 Pfam PF00579 tRNA synthetases class I (W and Y) 5 285 8.9E-77 T 17-03-2017 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 14 24 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 SUPERFAMILY SSF52374 7 332 6.43E-95 T 17-03-2017 SHXM_RS25155 51f0045a04dccfd2de52a7d98c968ab1 337 Gene3D G3DSA:3.40.50.620 5 214 1.0E-86 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 172 286 3.2E-13 T 17-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 SUPERFAMILY SSF51735 9 166 5.87E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 PIRSF PIRSF000103 2 295 4.4E-70 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 Gene3D G3DSA:1.10.1040.10 172 287 1.6E-25 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 Gene3D G3DSA:3.40.50.720 4 170 4.4E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 SUPERFAMILY SSF48179 172 288 7.48E-24 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS20325 8d1cd4935e1228e0bd7d641fbf009b70 297 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 10 165 5.7E-34 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS28515 29c3adc979095304cc87da53b3e1196f 323 SUPERFAMILY SSF51182 24 317 4.07E-83 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS28515 29c3adc979095304cc87da53b3e1196f 323 Pfam PF02678 Pirin 41 146 4.3E-31 T 17-03-2017 IPR003829 Pirin, N-terminal domain SHXM_RS28515 29c3adc979095304cc87da53b3e1196f 323 Pfam PF05726 Pirin C-terminal cupin domain 202 309 1.1E-32 T 17-03-2017 IPR008778 Pirin, C-terminal domain SHXM_RS28515 29c3adc979095304cc87da53b3e1196f 323 Gene3D G3DSA:2.60.120.10 24 282 5.5E-78 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS28515 29c3adc979095304cc87da53b3e1196f 323 PIRSF PIRSF006232 22 318 6.8E-92 T 17-03-2017 IPR012093 Pirin SHXM_RS04150 b0e8557ddb68d14680da2280ec99cf78 398 Pfam PF13641 Glycosyltransferase like family 2 31 261 1.2E-28 T 17-03-2017 SHXM_RS04150 b0e8557ddb68d14680da2280ec99cf78 398 SUPERFAMILY SSF53448 32 272 7.69E-31 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS04150 b0e8557ddb68d14680da2280ec99cf78 398 Gene3D G3DSA:3.90.550.10 34 266 1.2E-15 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS40530 3f9c91703c545c0144c7f53a4c30c573 485 Pfam PF00171 Aldehyde dehydrogenase family 19 468 1.8E-154 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS40530 3f9c91703c545c0144c7f53a4c30c573 485 Gene3D G3DSA:3.40.605.10 6 260 3.4E-89 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS40530 3f9c91703c545c0144c7f53a4c30c573 485 SUPERFAMILY SSF53720 6 469 1.57E-151 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS40530 3f9c91703c545c0144c7f53a4c30c573 485 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 274 285 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS40530 3f9c91703c545c0144c7f53a4c30c573 485 Gene3D G3DSA:3.40.309.10 261 448 1.5E-58 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS40530 3f9c91703c545c0144c7f53a4c30c573 485 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 246 253 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS28005 7e6571ee7d7264932d85f36ef73fab51 343 SUPERFAMILY SSF51419 9 176 4.09E-16 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS28005 7e6571ee7d7264932d85f36ef73fab51 343 Pfam PF01168 Alanine racemase, N-terminal domain 8 168 1.8E-14 T 17-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS28005 7e6571ee7d7264932d85f36ef73fab51 343 Gene3D G3DSA:3.20.20.10 25 175 4.1E-15 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 Gene3D G3DSA:1.10.630.10 32 407 1.1E-115 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 349 358 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 Pfam PF00067 Cytochrome P450 200 366 6.2E-22 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00385 P450 superfamily signature 356 367 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00385 P450 superfamily signature 280 291 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00385 P450 superfamily signature 245 262 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00385 P450 superfamily signature 347 356 5.7E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 SUPERFAMILY SSF48264 38 407 7.86E-91 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 102 113 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 280 291 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 203 225 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 326 341 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 149 165 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 347 356 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 166 181 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 298 325 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS04240 4f5b696d6f89a9e9ba1d8f61aad3255d 407 PRINTS PR00359 B-class P450 signature 356 367 3.0E-56 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 Pfam PF00912 Transglycosylase 79 255 5.3E-55 T 17-03-2017 IPR001264 Glycosyl transferase, family 51 SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 Gene3D G3DSA:3.40.710.10 256 685 1.0E-94 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 SUPERFAMILY SSF56601 288 656 4.08E-81 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 SUPERFAMILY SSF56601 241 259 4.08E-81 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 Pfam PF00905 Penicillin binding protein transpeptidase domain 353 599 1.8E-35 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 SUPERFAMILY SSF53955 72 270 1.91E-58 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS33575 ee4ed7b8823cec696b6a2a946c250bc9 744 Gene3D G3DSA:1.10.3810.10 79 255 3.9E-60 T 17-03-2017 SHXM_RS31830 181020e96a5ee19397f982c622f4da5c 409 Gene3D G3DSA:3.20.20.140 85 398 9.1E-64 T 17-03-2017 SHXM_RS31830 181020e96a5ee19397f982c622f4da5c 409 Gene3D G3DSA:3.20.20.140 6 34 9.1E-64 T 17-03-2017 SHXM_RS31830 181020e96a5ee19397f982c622f4da5c 409 SUPERFAMILY SSF51556 6 34 1.51E-68 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31830 181020e96a5ee19397f982c622f4da5c 409 SUPERFAMILY SSF51556 98 397 1.51E-68 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31830 181020e96a5ee19397f982c622f4da5c 409 Pfam PF04909 Amidohydrolase 98 397 1.7E-39 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS02790 c08386c39587f8825f3194ec34db15be 316 SUPERFAMILY SSF56112 9 279 2.04E-19 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS02790 c08386c39587f8825f3194ec34db15be 316 Gene3D G3DSA:3.90.1200.10 109 252 4.2E-9 T 17-03-2017 SHXM_RS43080 e23345bcd08639706428947d31586653 139 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 11 128 4.8E-29 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS43080 e23345bcd08639706428947d31586653 139 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 6 92 4.3E-14 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS43080 e23345bcd08639706428947d31586653 139 SUPERFAMILY SSF50475 6 130 9.75E-27 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS43080 e23345bcd08639706428947d31586653 139 Gene3D G3DSA:2.30.110.10 6 134 2.6E-28 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS50330 701690dd78509877c2bc2a5fb490f85a 303 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 122 292 3.4E-27 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50330 701690dd78509877c2bc2a5fb490f85a 303 SUPERFAMILY SSF161098 99 283 3.27E-31 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50330 701690dd78509877c2bc2a5fb490f85a 303 Gene3D G3DSA:1.10.3720.10 98 292 2.2E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11275 9356bed5f28f03998a376a3b6be9b6c7 266 Pfam PF12697 Alpha/beta hydrolase family 25 252 1.2E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11275 9356bed5f28f03998a376a3b6be9b6c7 266 Gene3D G3DSA:3.40.50.1820 4 256 9.9E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11275 9356bed5f28f03998a376a3b6be9b6c7 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 48 63 7.7E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11275 9356bed5f28f03998a376a3b6be9b6c7 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 92 105 7.7E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11275 9356bed5f28f03998a376a3b6be9b6c7 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 106 119 7.7E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11275 9356bed5f28f03998a376a3b6be9b6c7 266 SUPERFAMILY SSF53474 7 259 3.82E-44 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14365 a868ea6167fe06d6b40f2db936ff1fed 287 Gene3D G3DSA:3.20.20.60 5 253 3.6E-55 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS14365 a868ea6167fe06d6b40f2db936ff1fed 287 Pfam PF13714 Phosphoenolpyruvate phosphomutase 15 244 2.4E-33 T 17-03-2017 SHXM_RS14365 a868ea6167fe06d6b40f2db936ff1fed 287 SUPERFAMILY SSF51621 4 250 1.57E-57 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS36620 a4e92a9e3c36e21292a4ecd159f49ed2 102 Pfam PF10611 Protein of unknown function (DUF2469) 1 100 1.6E-52 T 17-03-2017 IPR019592 Protein of unknown function DUF2469 SHXM_RS14935 eeac4e3e17dc18fe394e56c43ddb5faa 214 Gene3D G3DSA:1.10.3720.10 8 210 5.7E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14935 eeac4e3e17dc18fe394e56c43ddb5faa 214 SUPERFAMILY SSF161098 11 196 7.33E-34 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14935 eeac4e3e17dc18fe394e56c43ddb5faa 214 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 10 105 1.2E-17 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS14935 eeac4e3e17dc18fe394e56c43ddb5faa 214 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 30 209 6.1E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15750 e9759388f2e1387ddcc0571d50d3671c 415 SUPERFAMILY SSF53098 114 279 7.89E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15750 e9759388f2e1387ddcc0571d50d3671c 415 Pfam PF00665 Integrase core domain 114 241 2.6E-18 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15750 e9759388f2e1387ddcc0571d50d3671c 415 Gene3D G3DSA:3.30.420.10 115 281 5.0E-18 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15750 e9759388f2e1387ddcc0571d50d3671c 415 Pfam PF13936 Helix-turn-helix domain 8 40 2.6E-6 T 17-03-2017 IPR025246 Transposase IS30-like HTH domain SHXM_RS15750 e9759388f2e1387ddcc0571d50d3671c 415 Gene3D G3DSA:1.10.10.60 8 41 1.8E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14270 085356e4c31e530446baae14a681d8a7 429 Gene3D G3DSA:3.40.710.10 59 416 3.0E-70 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS14270 085356e4c31e530446baae14a681d8a7 429 SUPERFAMILY SSF56601 63 409 1.61E-70 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS14270 085356e4c31e530446baae14a681d8a7 429 Pfam PF00144 Beta-lactamase 66 405 1.2E-54 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS12505 7fa0709df85a541be33fc968339b1283 288 SUPERFAMILY SSF50891 111 283 5.11E-30 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS12505 7fa0709df85a541be33fc968339b1283 288 Pfam PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD 120 284 6.3E-24 T 17-03-2017 IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain GO:0000413|GO:0003755|GO:0006457 SHXM_RS12505 7fa0709df85a541be33fc968339b1283 288 Gene3D G3DSA:2.40.100.10 113 285 1.2E-31 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 SMART SM00825 Beta-ketoacyl synthase 10 377 9.2E-14 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 SUPERFAMILY SSF53901 6 216 1.35E-28 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 221 332 2.5E-30 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 Gene3D G3DSA:3.40.47.10 6 215 3.1E-23 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 SUPERFAMILY SSF53901 184 375 6.58E-53 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6 214 4.7E-16 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS37750 78d9fc80e87d1618d06f53e7875e4191 377 Gene3D G3DSA:3.40.47.10 229 376 1.5E-45 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23475 7df3578eac36c468abe6c3ce321ea9ab 306 SUPERFAMILY SSF47413 33 82 4.74E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS23475 7df3578eac36c468abe6c3ce321ea9ab 306 Pfam PF13560 Helix-turn-helix domain 6 87 3.6E-18 T 17-03-2017 SHXM_RS23475 7df3578eac36c468abe6c3ce321ea9ab 306 SMART SM00530 10 84 3.7E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS23475 7df3578eac36c468abe6c3ce321ea9ab 306 Gene3D G3DSA:1.10.260.40 2 83 4.1E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 SMART SM00346 18 106 1.5E-21 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 Pfam PF09339 IclR helix-turn-helix domain 26 69 2.9E-12 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 Gene3D G3DSA:1.10.10.10 18 84 5.2E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 SUPERFAMILY SSF46785 21 90 1.12E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 SUPERFAMILY SSF55781 81 256 6.54E-42 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 Pfam PF01614 Bacterial transcriptional regulator 137 239 2.2E-27 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS45785 cf88ab5035be68b589c819c6b061dcb7 260 Gene3D G3DSA:3.30.450.40 85 257 1.5E-46 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:1.10.1200.10 1511 1585 2.7E-25 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF08990 Erythronolide synthase docking 4 28 9.3E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF51735 993 1200 5.38E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF00550 Phosphopantetheine attachment site 1517 1582 1.3E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:3.40.47.10 30 297 1.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SMART SM01294 1515 1582 2.5E-6 T 17-03-2017 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF52151 769 870 1.36E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF52151 575 702 1.36E-67 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 198 214 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF51735 1210 1466 3.53E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 577 877 9.5E-117 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 293 410 4.3E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF55048 700 768 8.11E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF101173 3 35 1.19E-9 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SMART SM00823 Phosphopantetheine attachment site 1514 1586 4.8E-37 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:3.30.70.250 700 767 1.1E-9 T 17-03-2017 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF53901 31 401 5.61E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:3.40.50.720 1214 1407 1.1E-15 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF00698 Acyl transferase domain 576 895 9.6E-87 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1214 1401 1.7E-14 T 17-03-2017 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 35 285 1.3E-92 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SMART SM00825 Beta-ketoacyl synthase 37 463 4.3E-226 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 537 2.2E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1541 1556 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Pfam PF08659 KR domain 1214 1399 1.5E-26 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:3.40.47.10 298 463 7.6E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:3.40.366.10 575 696 6.0E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 Gene3D G3DSA:3.40.366.10 768 879 6.0E-74 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06435 15e54a9fbc957063c7f94bfaa4940467 1666 SUPERFAMILY SSF47336 1508 1592 1.28E-23 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS34550 c6082826d7de49a5b2b6c61d9b631c85 164 SUPERFAMILY SSF55874 45 135 5.31E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34550 c6082826d7de49a5b2b6c61d9b631c85 164 Gene3D G3DSA:3.30.565.10 49 134 1.4E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34550 c6082826d7de49a5b2b6c61d9b631c85 164 Pfam PF13581 Histidine kinase-like ATPase domain 17 129 3.0E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27095 ce000a7a902a232a588dd1e2b12f70ce 252 SUPERFAMILY SSF54593 126 245 1.29E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS27095 ce000a7a902a232a588dd1e2b12f70ce 252 Gene3D G3DSA:3.10.180.10 1 109 1.0E-25 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS27095 ce000a7a902a232a588dd1e2b12f70ce 252 Gene3D G3DSA:3.10.180.10 125 244 5.6E-28 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS27095 ce000a7a902a232a588dd1e2b12f70ce 252 SUPERFAMILY SSF54593 2 152 3.22E-17 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS27095 ce000a7a902a232a588dd1e2b12f70ce 252 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 128 237 3.0E-4 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS31530 bbe3b518b00087181048a247bd2fa2c7 366 SUPERFAMILY SSF88713 172 365 9.14E-30 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS31530 bbe3b518b00087181048a247bd2fa2c7 366 Pfam PF01522 Polysaccharide deacetylase 180 298 1.0E-20 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS31530 bbe3b518b00087181048a247bd2fa2c7 366 Gene3D G3DSA:3.20.20.370 172 365 3.5E-27 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 SUPERFAMILY SSF46548 128 253 8.2E-33 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 Gene3D G3DSA:3.10.20.30 20 127 3.5E-39 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 Pfam PF13183 4Fe-4S dicluster domain 167 239 9.7E-12 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 169 180 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 Gene3D G3DSA:1.10.1060.10 128 255 1.8E-39 T 17-03-2017 SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 TIGRFAM TIGR00384 dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur protein 30 249 4.6E-79 T 17-03-2017 IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein GO:0006099|GO:0016491|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 Pfam PF13085 2Fe-2S iron-sulfur cluster binding domain 27 132 9.5E-36 T 17-03-2017 IPR025192 Succinate dehydogenase/fumarate reductase N-terminal GO:0009055|GO:0051536 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25120 113bbd61fbe495e7e521c2a55ee6d7e3 257 SUPERFAMILY SSF54292 24 127 1.57E-28 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 Pfam PF07729 FCD domain 92 213 2.3E-25 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 56 1.2E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 56 72 1.2E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 SMART SM00895 92 214 2.5E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 SUPERFAMILY SSF48008 88 220 2.25E-27 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 Gene3D G3DSA:1.20.120.530 85 221 6.3E-30 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 SMART SM00345 24 82 4.7E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 SUPERFAMILY SSF46785 14 107 6.81E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 Pfam PF00392 Bacterial regulatory proteins, gntR family 21 82 7.5E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS14225 5a0fb711a0060f1774df939c6bea0de1 225 Gene3D G3DSA:1.10.10.10 12 83 1.2E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25795 3ec382d33daaaff6c21e0ed2dc9deca5 710 Gene3D G3DSA:3.40.50.300 205 267 5.5E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25795 3ec382d33daaaff6c21e0ed2dc9deca5 710 Gene3D G3DSA:3.40.50.300 406 547 5.5E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25795 3ec382d33daaaff6c21e0ed2dc9deca5 710 SUPERFAMILY SSF52540 466 702 7.07E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25795 3ec382d33daaaff6c21e0ed2dc9deca5 710 SUPERFAMILY SSF52540 198 366 7.07E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25795 3ec382d33daaaff6c21e0ed2dc9deca5 710 Gene3D G3DSA:3.40.50.300 548 702 1.2E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25795 3ec382d33daaaff6c21e0ed2dc9deca5 710 Pfam PF13245 Part of AAA domain 220 280 2.1E-12 T 17-03-2017 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 ProSitePatterns PS00449 ATP synthase a subunit signature. 193 202 - T 17-03-2017 IPR023011 ATPase, F0 complex, subunit A, active site Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 Pfam PF00119 ATP synthase A chain 48 261 2.3E-48 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 PRINTS PR00123 ATP synthase A subunit signature 105 121 7.0E-16 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 PRINTS PR00123 ATP synthase A subunit signature 190 212 7.0E-16 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 PRINTS PR00123 ATP synthase A subunit signature 248 263 7.0E-16 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 Hamap MF_01393 ATP synthase subunit a [atpB]. 27 268 12.652 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 TIGRFAM TIGR01131 ATP_synt_6_or_A: ATP synthase F0, A subunit 27 263 2.2E-41 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 SUPERFAMILY SSF81336 97 261 6.54E-34 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS35230 d11ed02ce5d89693322b95b9f186e1f7 269 Gene3D G3DSA:1.20.120.220 97 268 4.7E-38 T 17-03-2017 IPR000568 ATPase, F0 complex, subunit A GO:0015078|GO:0015986 Reactome: R-HSA-163210 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 Gene3D G3DSA:3.50.50.60 6 174 8.5E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 Gene3D G3DSA:3.50.50.60 268 348 8.5E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 Pfam PF01494 FAD binding domain 6 344 1.4E-81 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 SUPERFAMILY SSF51905 6 169 2.72E-60 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 SUPERFAMILY SSF51905 276 393 2.72E-60 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 7 29 6.4E-43 T 17-03-2017 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 313 331 6.4E-43 T 17-03-2017 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 280 295 6.4E-43 T 17-03-2017 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 295 311 6.4E-43 T 17-03-2017 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 148 163 6.4E-43 T 17-03-2017 SHXM_RS42880 f806a5e7b97345db2a5d776fb51b6ebb 497 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 331 347 6.4E-43 T 17-03-2017 SHXM_RS34785 eab05aa43b98c9dd9c58509b7602cc37 369 SUPERFAMILY SSF46785 10 120 2.14E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34785 eab05aa43b98c9dd9c58509b7602cc37 369 Gene3D G3DSA:1.10.10.10 4 99 1.1E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34785 eab05aa43b98c9dd9c58509b7602cc37 369 Pfam PF03551 Transcriptional regulator PadR-like family 14 82 1.2E-21 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 Pfam PF07690 Major Facilitator Superfamily 17 408 8.3E-60 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 15 39 5.3E-9 T 17-03-2017 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 137 161 5.3E-9 T 17-03-2017 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 337 357 5.3E-9 T 17-03-2017 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 399 418 5.3E-9 T 17-03-2017 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 Gene3D G3DSA:1.20.1250.20 13 196 8.7E-36 T 17-03-2017 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 Gene3D G3DSA:1.20.1250.20 270 465 3.9E-19 T 17-03-2017 SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 SUPERFAMILY SSF103473 248 468 4.97E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 SUPERFAMILY SSF103473 8 202 4.97E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20975 9ada1b09a8c3aaccc8bed1583e65d85f 496 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 11 417 3.0E-89 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SUPERFAMILY SSF56300 330 515 6.33E-24 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Pfam PF00149 Calcineurin-like phosphoesterase 356 509 2.2E-5 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Pfam PF13360 PQQ-like domain 1041 1122 8.4E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Pfam PF13360 PQQ-like domain 902 1012 8.0E-6 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Pfam PF13360 PQQ-like domain 749 836 3.9E-11 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SUPERFAMILY SSF117074 221 267 4.45E-6 T 17-03-2017 SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Gene3D G3DSA:3.60.21.10 328 521 7.0E-23 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Gene3D G3DSA:2.140.10.10 704 1121 7.1E-57 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SMART SM00564 750 786 1.3 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SMART SM00564 1060 1091 3.6E-4 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SMART SM00564 946 976 340.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SMART SM00564 993 1027 270.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SMART SM00564 794 826 0.0027 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SUPERFAMILY SSF50998 696 983 2.02E-24 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 SUPERFAMILY SSF50998 1050 1119 2.02E-24 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS48300 90adf78fa9c5964f5bc48c4f5597425d 1129 Pfam PF16371 N terminal of Calcineurin-like phosphoesterase 241 316 8.7E-12 T 17-03-2017 IPR032285 Calcineurin-like phosphoesterase, N-terminal SHXM_RS34745 03305ac2cd8e0336eaa72d543c3d1fa5 211 Gene3D G3DSA:1.10.3300.10 7 184 4.0E-46 T 17-03-2017 IPR023286 ABATE domain SHXM_RS34745 03305ac2cd8e0336eaa72d543c3d1fa5 211 Pfam PF11706 CGNR zinc finger 141 183 2.4E-15 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS34745 03305ac2cd8e0336eaa72d543c3d1fa5 211 Pfam PF07336 Putative stress-induced transcription regulator 8 122 3.2E-16 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS34745 03305ac2cd8e0336eaa72d543c3d1fa5 211 SUPERFAMILY SSF160904 7 182 7.32E-39 T 17-03-2017 SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 SMART SM00825 Beta-ketoacyl synthase 7 396 6.4E-62 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 262 361 4.9E-23 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 SUPERFAMILY SSF51197 534 830 6.32E-14 T 17-03-2017 SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 168 184 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 8 255 1.9E-58 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 Gene3D G3DSA:3.40.47.10 268 361 1.3E-23 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 SUPERFAMILY SSF53901 3 121 1.71E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 SUPERFAMILY SSF53901 151 361 1.71E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 Gene3D G3DSA:3.60.130.10 572 834 1.7E-15 T 17-03-2017 SHXM_RS50020 56a3d8ccd5ed10d4d405024748523eb8 856 Gene3D G3DSA:3.40.47.10 7 267 8.2E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS10755 d3200c5182d3a0b4816a870c741bdf50 354 SUPERFAMILY SSF52777 38 207 2.78E-35 T 17-03-2017 SHXM_RS10755 d3200c5182d3a0b4816a870c741bdf50 354 Pfam PF00668 Condensation domain 37 340 8.1E-36 T 17-03-2017 IPR001242 Condensation domain SHXM_RS10755 d3200c5182d3a0b4816a870c741bdf50 354 SUPERFAMILY SSF52777 255 342 6.56E-15 T 17-03-2017 SHXM_RS37420 82e65bb7d925b9db2f30ca32365760d2 297 Pfam PF03747 ADP-ribosylglycohydrolase 13 273 2.9E-47 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS37420 82e65bb7d925b9db2f30ca32365760d2 297 SUPERFAMILY SSF101478 4 291 1.57E-55 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS48555 4427f5ff47ecfbb1413b6eb4ca08d131 382 Pfam PF00155 Aminotransferase class I and II 36 375 1.4E-54 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS48555 4427f5ff47ecfbb1413b6eb4ca08d131 382 Gene3D G3DSA:3.40.640.10 53 266 4.7E-75 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS48555 4427f5ff47ecfbb1413b6eb4ca08d131 382 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 230 239 - T 17-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SHXM_RS48555 4427f5ff47ecfbb1413b6eb4ca08d131 382 Gene3D G3DSA:3.90.1150.10 267 375 5.0E-14 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS48555 4427f5ff47ecfbb1413b6eb4ca08d131 382 SUPERFAMILY SSF53383 6 377 1.09E-90 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 Gene3D G3DSA:3.90.226.10 20 193 8.1E-77 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 Pfam PF00574 Clp protease 20 192 2.3E-78 T 17-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 SUPERFAMILY SSF52096 20 193 7.46E-67 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 ProSitePatterns PS00382 Endopeptidase Clp histidine active site. 112 125 - T 17-03-2017 IPR033135 ClpP, histidine active site SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 4 193 40.278 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 PRINTS PR00127 Clp protease catalytic subunit P signature 111 130 7.1E-49 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 PRINTS PR00127 Clp protease catalytic subunit P signature 90 107 7.1E-49 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 PRINTS PR00127 Clp protease catalytic subunit P signature 168 187 7.1E-49 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 PRINTS PR00127 Clp protease catalytic subunit P signature 20 35 7.1E-49 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS21705 1ab76ed889fadcaff555fb0cfe3675df 204 PRINTS PR00127 Clp protease catalytic subunit P signature 59 79 7.1E-49 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS13750 3fb495b4d231b89943769b66b453e49e 29 Pfam PF09604 F subunit of K+-transporting ATPase (Potass_KdpF) 7 29 8.3E-9 T 17-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 SHXM_RS13750 3fb495b4d231b89943769b66b453e49e 29 TIGRFAM TIGR02115 potass_kdpF: K+-transporting ATPase, F subunit 7 29 7.8E-9 T 17-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 SHXM_RS45060 501dd3f38f5c74d83284b26bd7dd169e 470 Pfam PF00027 Cyclic nucleotide-binding domain 116 204 8.1E-12 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS45060 501dd3f38f5c74d83284b26bd7dd169e 470 SUPERFAMILY SSF51206 91 210 5.63E-19 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS45060 501dd3f38f5c74d83284b26bd7dd169e 470 Gene3D G3DSA:2.60.120.10 91 212 1.6E-21 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS45060 501dd3f38f5c74d83284b26bd7dd169e 470 SMART SM00100 96 217 8.1E-8 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS38130 d99c5eb9f4e58b0829b9cac0c4a7aee3 187 Pfam PF00440 Bacterial regulatory proteins, tetR family 4 50 3.5E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38130 d99c5eb9f4e58b0829b9cac0c4a7aee3 187 ProSitePatterns PS01081 TetR-type HTH domain signature. 16 46 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS38130 d99c5eb9f4e58b0829b9cac0c4a7aee3 187 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 48 1.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38130 d99c5eb9f4e58b0829b9cac0c4a7aee3 187 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 4 17 1.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38130 d99c5eb9f4e58b0829b9cac0c4a7aee3 187 Gene3D G3DSA:1.10.357.10 3 183 5.4E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS38130 d99c5eb9f4e58b0829b9cac0c4a7aee3 187 SUPERFAMILY SSF46689 2 67 3.14E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 Gene3D G3DSA:1.10.10.10 131 228 6.3E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 Gene3D G3DSA:3.40.50.2300 7 130 5.3E-39 T 17-03-2017 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 SUPERFAMILY SSF52172 8 140 3.42E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 Pfam PF00072 Response regulator receiver domain 11 122 1.6E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 SUPERFAMILY SSF46894 158 227 3.74E-22 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 197 6.4E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 181 6.4E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 197 209 6.4E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 ProSitePatterns PS00622 LuxR-type HTH domain signature. 181 208 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 Pfam PF00196 Bacterial regulatory proteins, luxR family 166 221 1.6E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 SMART SM00448 9 122 1.2E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS29275 7beb6795ccce1722a01ad4a6232f79fb 231 SMART SM00421 164 221 2.6E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 Gene3D G3DSA:3.40.50.300 10 249 3.2E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 SUPERFAMILY SSF50331 259 356 2.15E-6 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 SMART SM00382 42 225 1.4E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 Pfam PF08402 TOBE domain 270 356 5.3E-12 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 SUPERFAMILY SSF52540 18 255 7.81E-84 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 Pfam PF00005 ABC transporter 34 175 5.3E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS43830 93b5a2c034f98f1f7d0b6bc684e98359 360 ProSitePatterns PS00211 ABC transporters family signature. 148 162 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS25730 997149cb3144b2f628e2c0539480c1b7 298 Pfam PF02621 Menaquinone biosynthesis 15 282 9.4E-88 T 17-03-2017 IPR003773 Menaquinone biosynthesis enzyme SHXM_RS25730 997149cb3144b2f628e2c0539480c1b7 298 Hamap MF_00996 1,4-dihydroxy-6-naphtoate synthase [mqnD]. 14 288 39.465 T 17-03-2017 IPR030869 1,4-dihydroxy-6-naphtoate synthase GO:0009234|GO:0016829 SHXM_RS25730 997149cb3144b2f628e2c0539480c1b7 298 Gene3D G3DSA:3.40.190.10 89 197 6.6E-14 T 17-03-2017 SHXM_RS25730 997149cb3144b2f628e2c0539480c1b7 298 SUPERFAMILY SSF53850 15 287 4.78E-81 T 17-03-2017 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 Gene3D G3DSA:1.10.150.20 339 481 8.4E-18 T 17-03-2017 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 SMART SM00482 316 521 6.9E-12 T 17-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 Pfam PF00476 DNA polymerase family A 247 538 1.9E-28 T 17-03-2017 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 Gene3D G3DSA:3.30.70.370 299 338 4.3E-12 T 17-03-2017 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 Gene3D G3DSA:3.30.70.370 482 547 4.3E-12 T 17-03-2017 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 PRINTS PR00868 DNA-polymerase family A (pol I) signature 360 373 4.4E-8 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 PRINTS PR00868 DNA-polymerase family A (pol I) signature 504 517 4.4E-8 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 PRINTS PR00868 DNA-polymerase family A (pol I) signature 330 353 4.4E-8 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 PRINTS PR00868 DNA-polymerase family A (pol I) signature 474 490 4.4E-8 T 17-03-2017 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS26550 5c3f72e23d383f9044a8ef0235edfd6f 562 SUPERFAMILY SSF56672 161 561 4.67E-67 T 17-03-2017 SHXM_RS44090 9c6b6a00e895a03f017c3027c6cdfe94 182 Gene3D G3DSA:3.30.70.1060 1 90 2.0E-18 T 17-03-2017 SHXM_RS44090 9c6b6a00e895a03f017c3027c6cdfe94 182 SUPERFAMILY SSF54909 1 90 2.14E-14 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44090 9c6b6a00e895a03f017c3027c6cdfe94 182 Pfam PF03795 YCII-related domain 1 88 3.2E-17 T 17-03-2017 IPR005545 YCII-related SHXM_RS18700 a6896485a154f1ff4cb278c1a1e41cc6 296 Gene3D G3DSA:3.20.20.70 37 284 4.1E-55 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18700 a6896485a154f1ff4cb278c1a1e41cc6 296 Pfam PF05690 Thiazole biosynthesis protein ThiG 39 281 3.8E-105 T 17-03-2017 SHXM_RS18700 a6896485a154f1ff4cb278c1a1e41cc6 296 SUPERFAMILY SSF110399 35 273 1.44E-80 T 17-03-2017 IPR008867 Thiazole biosynthesis GO:0009228 KEGG: 00730+2.8.1.10|MetaCyc: PWY-6891|MetaCyc: PWY-6892 SHXM_RS18700 a6896485a154f1ff4cb278c1a1e41cc6 296 Hamap MF_00443 Thiazole synthase [thiG]. 36 287 42.417 T 17-03-2017 IPR008867 Thiazole biosynthesis GO:0009228 KEGG: 00730+2.8.1.10|MetaCyc: PWY-6891|MetaCyc: PWY-6892 SHXM_RS16485 7b2f3a5b7e9938a613a3797b486c1e8d 171 Gene3D G3DSA:2.40.380.10 2 162 5.1E-18 T 17-03-2017 IPR007295 Domain of unknown function DUF402 SHXM_RS16485 7b2f3a5b7e9938a613a3797b486c1e8d 171 Pfam PF04167 Protein of unknown function (DUF402) 58 120 8.3E-16 T 17-03-2017 IPR007295 Domain of unknown function DUF402 SHXM_RS16485 7b2f3a5b7e9938a613a3797b486c1e8d 171 SUPERFAMILY SSF159234 3 162 6.15E-18 T 17-03-2017 SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 Gene3D G3DSA:1.10.10.10 17 69 1.1E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 Gene3D G3DSA:3.30.70.920 70 157 3.0E-21 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 Pfam PF01037 Lrp/AsnC ligand binding domain 91 155 1.4E-12 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 SUPERFAMILY SSF46785 18 77 8.67E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 18 34 2.4E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 34 45 2.4E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 45 64 2.4E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 SUPERFAMILY SSF54909 81 155 4.42E-14 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 Pfam PF13412 Winged helix-turn-helix DNA-binding 18 65 1.7E-13 T 17-03-2017 SHXM_RS28365 ca13f9a58ef809b7e74d4ddf2d96cda5 162 SMART SM00344 18 124 1.4E-19 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 SMART SM00354 26 96 3.4E-32 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 ProSitePatterns PS00356 LacI-type HTH domain signature. 29 47 - T 17-03-2017 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 Gene3D G3DSA:3.40.50.2300 197 337 2.2E-51 T 17-03-2017 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 SUPERFAMILY SSF47413 27 84 1.83E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 Gene3D G3DSA:1.10.260.40 27 78 6.4E-27 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 Gene3D G3DSA:3.40.50.2300 79 196 3.6E-35 T 17-03-2017 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 Pfam PF13377 Periplasmic binding protein-like domain 192 356 7.2E-40 T 17-03-2017 SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 SUPERFAMILY SSF53822 86 357 1.26E-67 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS04740 4775ad8b050535372df51eedc4714f4b 365 Pfam PF00356 Bacterial regulatory proteins, lacI family 28 73 6.8E-19 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 Pfam PF00486 Transcriptional regulatory protein, C terminal 165 237 5.8E-19 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 Gene3D G3DSA:3.40.50.2300 8 140 4.1E-39 T 17-03-2017 SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 SUPERFAMILY SSF52172 15 196 8.25E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 SMART SM00448 17 129 3.1E-39 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 Gene3D G3DSA:1.10.10.10 142 238 7.0E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 Pfam PF00072 Response regulator receiver domain 19 129 1.1E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19930 6095f14fd7bb707bf5a28924032705da 244 SMART SM00862 163 238 9.3E-21 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 17 68 1.4E-7 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 SUPERFAMILY SSF47741 97 183 1.44E-26 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 SUPERFAMILY SSF54292 12 88 4.06E-25 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 Gene3D G3DSA:1.10.150.120 86 185 5.4E-29 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 49 57 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 Gene3D G3DSA:3.10.20.30 12 85 7.5E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS03560 72e05d321737223a589e5a124e0c8dc0 199 Pfam PF01799 [2Fe-2S] binding domain 83 177 1.2E-28 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS32010 a821b665e3d5257e1bfaaaf69bc42f4a 343 SUPERFAMILY SSF53686 11 304 3.17E-46 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS32010 a821b665e3d5257e1bfaaaf69bc42f4a 343 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 13 304 2.9E-21 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS32010 a821b665e3d5257e1bfaaaf69bc42f4a 343 PIRSF PIRSF006278 5 313 1.9E-63 T 17-03-2017 IPR027278 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase SHXM_RS32010 a821b665e3d5257e1bfaaaf69bc42f4a 343 Gene3D G3DSA:3.40.50.1100 104 304 7.9E-36 T 17-03-2017 SHXM_RS49555 4ec9a523955d95a65f0e2557803f0624 442 Gene3D G3DSA:3.40.190.10 46 181 3.5E-14 T 17-03-2017 SHXM_RS49555 4ec9a523955d95a65f0e2557803f0624 442 Pfam PF01547 Bacterial extracellular solute-binding protein 52 352 4.2E-29 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS49555 4ec9a523955d95a65f0e2557803f0624 442 Gene3D G3DSA:3.40.190.10 182 362 1.9E-28 T 17-03-2017 SHXM_RS49555 4ec9a523955d95a65f0e2557803f0624 442 SUPERFAMILY SSF53850 35 436 7.41E-63 T 17-03-2017 SHXM_RS49710 3dc8ae93e86d71f40adae4144e9c29e6 499 Pfam PF00155 Aminotransferase class I and II 187 488 5.4E-9 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS49710 3dc8ae93e86d71f40adae4144e9c29e6 499 Gene3D G3DSA:3.40.720.10 33 131 4.4E-4 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS49710 3dc8ae93e86d71f40adae4144e9c29e6 499 Gene3D G3DSA:3.40.640.10 178 355 1.8E-43 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS49710 3dc8ae93e86d71f40adae4144e9c29e6 499 Gene3D G3DSA:3.90.1150.10 356 483 1.8E-6 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS49710 3dc8ae93e86d71f40adae4144e9c29e6 499 SUPERFAMILY SSF53649 32 107 4.45E-6 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS49710 3dc8ae93e86d71f40adae4144e9c29e6 499 SUPERFAMILY SSF53383 136 497 7.32E-59 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS33120 f1755fd2644429e9d6f78bd2ab522755 163 Pfam PF00583 Acetyltransferase (GNAT) family 55 134 1.1E-10 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS33120 f1755fd2644429e9d6f78bd2ab522755 163 Gene3D G3DSA:3.40.630.30 1 159 9.9E-31 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33120 f1755fd2644429e9d6f78bd2ab522755 163 SUPERFAMILY SSF55729 1 148 7.55E-28 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 PRINTS PR00400 Tetracycline repressor protein signature 24 47 2.3E-6 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 PRINTS PR00400 Tetracycline repressor protein signature 188 202 2.3E-6 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 PRINTS PR00400 Tetracycline repressor protein signature 133 152 2.3E-6 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 54 8.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 SUPERFAMILY SSF46689 1 65 3.25E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 71 203 5.5E-17 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 SUPERFAMILY SSF48498 70 203 3.11E-25 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS36190 5b1e87a8067eef37b911ad256474c92e 204 Gene3D G3DSA:1.10.357.10 1 203 1.1E-51 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47800 70059bafd3177d0d8b6e12f722cccc83 151 Pfam PF12680 SnoaL-like domain 14 121 1.3E-16 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS47800 70059bafd3177d0d8b6e12f722cccc83 151 Gene3D G3DSA:3.10.450.50 3 145 2.5E-51 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS47800 70059bafd3177d0d8b6e12f722cccc83 151 SUPERFAMILY SSF54427 8 136 7.62E-34 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 SMART SM00829 10 343 1.0E-4 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 Gene3D G3DSA:3.90.180.10 1 179 3.9E-50 T 17-03-2017 IPR011032 GroES-like SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 Pfam PF00107 Zinc-binding dehydrogenase 182 306 8.4E-18 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 SUPERFAMILY SSF51735 143 315 1.65E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 SUPERFAMILY SSF50129 1 187 3.46E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 61 75 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 Gene3D G3DSA:3.40.50.720 180 275 2.8E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10710 ba6e3a642b5301a83203065da3fc0597 346 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 139 1.3E-30 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 SUPERFAMILY SSF47616 161 323 4.73E-34 T 17-03-2017 IPR010987 Glutathione S-transferase, C-terminal-like SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 Pfam PF13410 Glutathione S-transferase, C-terminal domain 190 260 2.9E-12 T 17-03-2017 SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 PIRSF PIRSF015753 2 309 1.9E-104 T 17-03-2017 IPR016639 Glutathione S-transferase (GST) KEGG: 00480+2.5.1.18|KEGG: 00980+2.5.1.18|KEGG: 00982+2.5.1.18|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112|MetaCyc: PWY-7533 SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 SUPERFAMILY SSF52833 24 143 3.69E-5 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 Gene3D G3DSA:1.20.1050.10 158 273 1.4E-21 T 17-03-2017 IPR010987 Glutathione S-transferase, C-terminal-like SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 Pfam PF13409 Glutathione S-transferase, N-terminal domain 48 142 6.1E-7 T 17-03-2017 IPR004045 Glutathione S-transferase, N-terminal GO:0005515 SHXM_RS04215 cd276173afbb29e56c2f323dde94444e 339 Gene3D G3DSA:3.40.30.10 24 157 2.1E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Pfam PF00310 Glutamine amidotransferases class-II 22 432 4.7E-181 T 17-03-2017 IPR017932 Glutamine amidotransferase type 2 domain SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Pfam PF01493 GXGXG motif 1260 1429 8.2E-75 T 17-03-2017 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 SUPERFAMILY SSF51395 447 1211 4.89E-261 T 17-03-2017 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Gene3D G3DSA:2.160.20.60 1230 1504 6.1E-102 T 17-03-2017 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 SUPERFAMILY SSF56235 22 434 9.12E-149 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Gene3D G3DSA:3.60.20.10 22 442 8.6E-187 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Gene3D G3DSA:3.20.20.70 845 1207 4.3E-178 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Pfam PF01645 Conserved region in glutamate synthase 811 1175 1.6E-155 T 17-03-2017 IPR002932 Glutamate synthase domain GO:0006537|GO:0015930|GO:0016638|GO:0055114 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Pfam PF04898 Glutamate synthase central domain 459 747 3.5E-112 T 17-03-2017 IPR006982 Glutamate synthase, central-N GO:0006807|GO:0015930|GO:0055114 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 SUPERFAMILY SSF69336 1224 1489 4.97E-87 T 17-03-2017 IPR002489 Glutamate synthase, alpha subunit, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS18285 2c2f9ed3ea1d34c77a329755141dd1ed 1516 Gene3D G3DSA:3.20.20.70 443 799 2.0E-102 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS04600 b70c027bbe51c10df2c2229c99a19430 201 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 5 191 4.5E-20 T 17-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 Gene3D G3DSA:3.40.50.300 18 272 2.0E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 SMART SM00382 49 248 3.6E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 Pfam PF00005 ABC transporter 41 198 1.2E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 SUPERFAMILY SSF52540 20 270 1.2E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 250 310 3.3E-13 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 248 337 5.1E-18 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS12090 7761a80ea536282866abbb2ae1d7278e 352 ProSitePatterns PS00211 ABC transporters family signature. 171 185 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS13790 26444fdb01f364449c64ffad514bfc7c 266 Gene3D G3DSA:1.10.3210.10 83 175 5.3E-9 T 17-03-2017 IPR006674 HD domain SHXM_RS13790 26444fdb01f364449c64ffad514bfc7c 266 Pfam PF01966 HD domain 86 173 9.6E-9 T 17-03-2017 IPR006674 HD domain SHXM_RS13790 26444fdb01f364449c64ffad514bfc7c 266 SMART SM00471 81 200 8.1E-5 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS13790 26444fdb01f364449c64ffad514bfc7c 266 SUPERFAMILY SSF109604 77 169 9.91E-16 T 17-03-2017 SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 92 1.5E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 SMART SM00829 10 314 2.8E-13 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 SUPERFAMILY SSF51735 115 216 2.4E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 SUPERFAMILY SSF50129 1 147 1.48E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 Gene3D G3DSA:3.40.50.720 146 217 1.9E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 Gene3D G3DSA:3.90.180.10 1 145 4.8E-40 T 17-03-2017 IPR011032 GroES-like SHXM_RS00195 078821bbe65601b4af6029e35950a127 316 Pfam PF13602 Zinc-binding dehydrogenase 197 313 2.2E-8 T 17-03-2017 SHXM_RS36850 0cf9d31776e8c9f9d2515fe07b147ce3 233 Pfam PF01670 Glycosyl hydrolase family 12 46 228 4.5E-20 T 17-03-2017 IPR002594 Glycoside hydrolase family 12 GO:0000272|GO:0008810 SHXM_RS36850 0cf9d31776e8c9f9d2515fe07b147ce3 233 Gene3D G3DSA:2.60.120.180 32 231 3.8E-58 T 17-03-2017 IPR013319 Glycoside hydrolase family 11/12 GO:0004553 MetaCyc: PWY-6784 SHXM_RS36850 0cf9d31776e8c9f9d2515fe07b147ce3 233 SUPERFAMILY SSF49899 32 230 8.37E-51 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 SUPERFAMILY SSF54909 73 145 2.15E-6 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 Gene3D G3DSA:1.10.10.10 9 57 2.9E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 SUPERFAMILY SSF54909 246 324 2.15E-5 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 Gene3D G3DSA:3.30.70.920 74 146 1.2E-9 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 Gene3D G3DSA:3.30.70.920 252 324 2.2E-6 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 Gene3D G3DSA:1.10.10.10 187 251 3.0E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 SUPERFAMILY SSF46785 9 57 8.62E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 SMART SM00344 195 292 5.2E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 SMART SM00344 10 115 1.2E-6 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 37 56 1.2E-6 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 10 26 1.2E-6 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 SUPERFAMILY SSF46785 187 237 4.26E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41045 666cfdbba103372e283b13b09ead9c40 335 Pfam PF13404 AsnC-type helix-turn-helix domain 10 51 2.5E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 Pfam PF00155 Aminotransferase class I and II 28 363 3.3E-62 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 Gene3D G3DSA:3.90.1150.10 274 369 1.1E-17 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 TIGRFAM TIGR01141 hisC: histidinol-phosphate transaminase 10 365 5.4E-93 T 17-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 Gene3D G3DSA:3.40.640.10 46 273 5.4E-63 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 230 239 - T 17-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 Hamap MF_01023 Histidinol-phosphate aminotransferase [hisC]. 8 367 53.296 T 17-03-2017 IPR005861 Histidinol-phosphate aminotransferase family GO:0000105|GO:0004400 KEGG: 00340+2.6.1.9|KEGG: 00350+2.6.1.9|KEGG: 00360+2.6.1.9|KEGG: 00400+2.6.1.9|KEGG: 00401+2.6.1.9|KEGG: 00960+2.6.1.9 SHXM_RS18415 6f7f82bf426c0af8d5b5d9e336de0c64 372 SUPERFAMILY SSF53383 27 366 1.93E-75 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS50190 47b844e9e0b8d6ad929f6c926f73b148 724 Pfam PF14742 N-terminal domain of (some) glycogen debranching enzymes 45 227 1.4E-22 T 17-03-2017 IPR032856 Putative glycogen debranching enzyme, N-terminal SHXM_RS50190 47b844e9e0b8d6ad929f6c926f73b148 724 Pfam PF06202 Amylo-alpha-1,6-glucosidase 296 656 3.2E-6 T 17-03-2017 IPR032790 Glycogen debranching enzyme, C-terminal KEGG: 00500+2.4.1.25+3.2.1.33|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238|Reactome: R-HSA-70221 SHXM_RS50190 47b844e9e0b8d6ad929f6c926f73b148 724 SUPERFAMILY SSF48208 291 713 6.8E-62 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 Gene3D G3DSA:3.40.630.30 129 289 2.0E-14 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 SUPERFAMILY SSF55718 305 410 9.81E-26 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 SUPERFAMILY SSF55729 4 304 2.95E-56 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 Pfam PF13527 Acetyltransferase (GNAT) domain 5 131 3.2E-30 T 17-03-2017 SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 Pfam PF13530 Sterol carrier protein domain 181 407 3.9E-49 T 17-03-2017 IPR025559 Enhanced intracellular survival protein domain SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 Gene3D G3DSA:3.40.630.30 3 128 4.0E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21750 92f833cbdd23d9c71c308d19abb10822 410 Gene3D G3DSA:3.30.1050.10 290 399 1.2E-26 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 2.5E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 2.5E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 2.5E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 Pfam PF13411 MerR HTH family regulatory protein 1 66 3.0E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 Gene3D G3DSA:1.10.1660.10 1 116 1.3E-24 T 17-03-2017 SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 SUPERFAMILY SSF46955 1 115 1.39E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS05895 30e8caff389a0a29c774f477c15125ad 133 SMART SM00422 1 69 1.1E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 75 2.7E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 SUPERFAMILY SSF46785 8 79 3.33E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 SUPERFAMILY SSF48008 81 212 9.68E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 Gene3D G3DSA:1.10.10.10 5 75 1.4E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 Gene3D G3DSA:1.20.120.530 79 210 4.7E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 Pfam PF07729 FCD domain 85 207 5.0E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 SMART SM00895 85 209 3.4E-16 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 65 9.8E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 35 49 9.8E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS28450 c64e5b0acb6d89edcc6b72a61f14bdf0 219 SMART SM00345 17 75 8.2E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09330 ca29c6f1e99b6f5f586e76862e34a17f 98 Pfam PF01609 Transposase DDE domain 3 75 1.3E-7 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 Gene3D G3DSA:1.10.10.10 129 218 1.7E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 SUPERFAMILY SSF52172 4 138 5.98E-31 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 Gene3D G3DSA:3.40.50.2300 3 128 9.1E-34 T 17-03-2017 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 SUPERFAMILY SSF46894 149 218 3.16E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 SMART SM00448 5 120 8.3E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 212 1.9E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 SMART SM00421 155 212 8.1E-27 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 1.6E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 1.6E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 1.6E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 Pfam PF00072 Response regulator receiver domain 7 119 1.7E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26700 0a0470862ff8debf902daf98fe42ee7d 219 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS49810 ce5466ebbbde88c94dba68804a4e7aad 419 PIRSF PIRSF029171 13 417 3.9E-75 T 17-03-2017 IPR005152 Lipase, secreted GO:0004806|GO:0016042 KEGG: 00561+3.1.1.3|MetaCyc: PWY-6857 SHXM_RS49810 ce5466ebbbde88c94dba68804a4e7aad 419 SUPERFAMILY SSF53474 337 413 1.91E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49810 ce5466ebbbde88c94dba68804a4e7aad 419 SUPERFAMILY SSF53474 55 293 1.91E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49810 ce5466ebbbde88c94dba68804a4e7aad 419 Gene3D G3DSA:3.40.50.1820 332 396 3.7E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49810 ce5466ebbbde88c94dba68804a4e7aad 419 Gene3D G3DSA:3.40.50.1820 98 244 3.7E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS48065 19dbf1e84e58e748e9ef0fa3210766ad 61 Pfam PF00872 Transposase, Mutator family 2 61 9.0E-16 T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS36090 11d45bce02913d0ece8daa204adf1da5 98 Pfam PF02686 Glu-tRNAGln amidotransferase C subunit 21 91 2.8E-16 T 17-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 SHXM_RS36090 11d45bce02913d0ece8daa204adf1da5 98 Hamap MF_00122 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C [gatC]. 3 96 23.68 T 17-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 SHXM_RS36090 11d45bce02913d0ece8daa204adf1da5 98 TIGRFAM TIGR00135 gatC: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit 4 95 6.6E-25 T 17-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 SHXM_RS36090 11d45bce02913d0ece8daa204adf1da5 98 SUPERFAMILY SSF141000 4 94 4.97E-27 T 17-03-2017 IPR003837 Glu-tRNAGln amidotransferase C subunit GO:0006450 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Gene3D G3DSA:2.40.30.10 220 317 8.9E-29 T 17-03-2017 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Gene3D G3DSA:3.30.70.870 318 427 1.4E-33 T 17-03-2017 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 46 61 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Gene3D G3DSA:2.40.50.250 508 602 1.1E-37 T 17-03-2017 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 SUPERFAMILY SSF50447 159 182 3.73E-31 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 SUPERFAMILY SSF50447 209 313 3.73E-31 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Gene3D G3DSA:3.30.70.240 428 506 3.3E-31 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 SUPERFAMILY SSF54980 424 537 6.47E-28 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 SMART SM00838 421 509 0.0034 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Pfam PF00679 Elongation factor G C-terminus 422 505 2.0E-21 T 17-03-2017 IPR000640 Translation elongation factor EFG, V domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Pfam PF03144 Elongation factor Tu domain 2 233 303 1.7E-10 T 17-03-2017 IPR004161 Translation elongation factor EFTu-like, domain 2 GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 SUPERFAMILY SSF52540 4 219 5.66E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 SUPERFAMILY SSF54980 317 413 3.6E-10 T 17-03-2017 IPR009022 Elongation factor G, III-V domain SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 PRINTS PR00315 GTP-binding elongation factor signature 53 61 1.4E-15 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 PRINTS PR00315 GTP-binding elongation factor signature 9 22 1.4E-15 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 PRINTS PR00315 GTP-binding elongation factor signature 79 89 1.4E-15 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 PRINTS PR00315 GTP-binding elongation factor signature 131 140 1.4E-15 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 PRINTS PR00315 GTP-binding elongation factor signature 95 106 1.4E-15 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 7 150 9.6E-23 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 TIGRFAM TIGR01394 TypA_BipA: GTP-binding protein TypA/BipA 7 624 9.0E-287 T 17-03-2017 IPR006298 GTP-binding protein TypA GO:0005525 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Pfam PF00009 Elongation factor Tu GTP binding domain 6 179 6.3E-52 T 17-03-2017 SHXM_RS33840 e1d83c776fcd3d53f055cecf4587d84f 631 Gene3D G3DSA:3.40.50.300 3 219 7.5E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SUPERFAMILY SSF51126 21 244 3.93E-25 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 Gene3D G3DSA:2.160.20.10 370 493 4.3E-9 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 Gene3D G3DSA:2.160.20.10 2 256 6.6E-19 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00382 589 728 5.1E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 Pfam PF05048 Periplasmic copper-binding protein (NosD) 313 458 9.3E-9 T 17-03-2017 IPR007742 Periplasmic copper-binding protein NosD, beta helix domain SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 153 175 750.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 432 454 29.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 409 431 74.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 455 477 6300.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 269 291 1900.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 130 152 150.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 176 198 480.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 200 222 5300.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 223 245 1000.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 246 268 5600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 341 363 6600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 387 408 47.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00710 364 385 5000.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 Gene3D G3DSA:3.40.50.300 553 742 1.9E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 594 724 1.9E-16 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 Pfam PF13229 Right handed beta helix region 124 244 3.9E-13 T 17-03-2017 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SUPERFAMILY SSF52540 551 780 6.65E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SUPERFAMILY SSF51126 308 486 3.31E-14 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 630 644 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 713 732 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 770 782 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 696 713 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 552 566 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 644 663 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 675 687 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 PRINTS PR00819 CbxX/CfqX superfamily signature 592 607 1.8E-48 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00722 315 476 1.2E-6 T 17-03-2017 IPR006633 Carbohydrate-binding/sugar hydrolysis domain SHXM_RS43290 6138d20d3fd2bfed8d3609ec37e5c5f7 812 SMART SM00722 42 174 0.16 T 17-03-2017 IPR006633 Carbohydrate-binding/sugar hydrolysis domain SHXM_RS03010 f5bd67f1f87cffc229f3b6c0fcacc097 227 Gene3D G3DSA:1.10.357.10 14 71 1.1E-22 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03010 f5bd67f1f87cffc229f3b6c0fcacc097 227 SUPERFAMILY SSF46689 17 71 3.79E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03010 f5bd67f1f87cffc229f3b6c0fcacc097 227 Pfam PF00440 Bacterial regulatory proteins, tetR family 27 70 1.5E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10315 03e333c313fb4f303b8242a52b839389 157 Gene3D G3DSA:1.10.357.10 33 155 6.6E-22 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS10315 03e333c313fb4f303b8242a52b839389 157 SUPERFAMILY SSF48498 51 155 6.23E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS10315 03e333c313fb4f303b8242a52b839389 157 SUPERFAMILY SSF46689 5 43 5.13E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10315 03e333c313fb4f303b8242a52b839389 157 Pfam PF16859 Bacterial transcriptional repressor C-terminal 50 153 1.7E-16 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS10315 03e333c313fb4f303b8242a52b839389 157 Gene3D G3DSA:1.10.10.60 5 31 2.8E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS32985 0a9472943e1457af1cdc0b8d39df9ba2 524 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 77 440 5.1E-68 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS32985 0a9472943e1457af1cdc0b8d39df9ba2 524 SUPERFAMILY SSF53850 31 518 3.26E-109 T 17-03-2017 SHXM_RS32985 0a9472943e1457af1cdc0b8d39df9ba2 524 Gene3D G3DSA:3.10.105.10 307 491 1.8E-37 T 17-03-2017 SHXM_RS32985 0a9472943e1457af1cdc0b8d39df9ba2 524 PIRSF PIRSF002741 1 521 1.3E-82 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS32985 0a9472943e1457af1cdc0b8d39df9ba2 524 Gene3D G3DSA:3.40.190.10 190 306 1.1E-24 T 17-03-2017 SHXM_RS32985 0a9472943e1457af1cdc0b8d39df9ba2 524 Gene3D G3DSA:3.90.76.10 43 189 5.0E-29 T 17-03-2017 SHXM_RS49255 a5120b60f5dcc1f903dc989b0bd7be3c 397 SUPERFAMILY SSF51126 36 371 9.03E-48 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS49255 a5120b60f5dcc1f903dc989b0bd7be3c 397 Gene3D G3DSA:2.160.20.10 36 370 1.2E-65 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS49255 a5120b60f5dcc1f903dc989b0bd7be3c 397 Pfam PF13229 Right handed beta helix region 131 320 5.0E-10 T 17-03-2017 SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 185 281 6.5E-27 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 PIRSF PIRSF000105 1 285 5.7E-83 T 17-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 SUPERFAMILY SSF48179 184 283 3.57E-28 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 Gene3D G3DSA:1.10.1040.10 187 282 1.6E-28 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 Gene3D G3DSA:3.40.50.720 4 186 3.5E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 8 182 6.8E-49 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS39575 e96e1e50a76946d9c2c2344ba8f0b2ba 286 SUPERFAMILY SSF51735 5 184 1.73E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:3.30.70.250 690 754 1.1E-8 T 17-03-2017 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF47336 1476 1561 3.93E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:3.40.366.10 560 686 2.8E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:3.40.366.10 755 873 2.8E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF53901 28 405 5.03E-99 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SMART SM01294 1484 1551 4.8E-5 T 17-03-2017 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:3.40.47.10 34 294 7.3E-86 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:3.40.47.10 295 461 6.7E-64 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 ProSitePatterns PS00012 Phosphopantetheine attachment site. 1510 1525 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF08990 Erythronolide synthase docking 3 27 5.9E-9 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 410 531 3.3E-14 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 32 282 1.1E-85 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:1.10.1200.10 1481 1555 8.4E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SMART SM00825 Beta-ketoacyl synthase 34 460 5.5E-207 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF00698 Acyl transferase domain 566 879 2.8E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1195 1375 6.5E-50 T 17-03-2017 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SMART SM00823 Phosphopantetheine attachment site 1483 1555 3.3E-31 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF52151 756 849 7.59E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF52151 564 691 7.59E-63 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Gene3D G3DSA:3.40.50.720 1195 1380 2.0E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF08659 KR domain 1195 1373 5.1E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 290 407 5.7E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 568 860 3.1E-113 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF51735 973 1181 2.4E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 Pfam PF00550 Phosphopantetheine attachment site 1486 1551 4.2E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF55048 690 755 1.44E-13 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS07230 59ae5813eca0ce4bb65b0404df466fbd 1633 SUPERFAMILY SSF51735 1191 1458 3.54E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50510 06bac45f4c05b13f4c7b97e5aedbef3c 877 PIRSF PIRSF010631 11 870 2.3E-261 T 17-03-2017 IPR016007 Alpha-L-rhamnosidase SHXM_RS50510 06bac45f4c05b13f4c7b97e5aedbef3c 877 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 155 324 5.0E-63 T 17-03-2017 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SHXM_RS50510 06bac45f4c05b13f4c7b97e5aedbef3c 877 SUPERFAMILY SSF48208 417 850 6.8E-48 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS50510 06bac45f4c05b13f4c7b97e5aedbef3c 877 Pfam PF05592 Bacterial alpha-L-rhamnosidase 334 849 2.4E-181 T 17-03-2017 IPR008902 Bacterial alpha-L-rhamnosidase SHXM_RS50510 06bac45f4c05b13f4c7b97e5aedbef3c 877 Gene3D G3DSA:2.60.120.260 323 432 4.6E-24 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS39580 66d6ee5f497a99bcc22a71813240ede4 89 SUPERFAMILY SSF47336 12 83 8.24E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39580 66d6ee5f497a99bcc22a71813240ede4 89 Pfam PF00550 Phosphopantetheine attachment site 27 76 5.3E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39580 66d6ee5f497a99bcc22a71813240ede4 89 Gene3D G3DSA:1.10.1200.10 7 80 1.0E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS00160 5014e4fc1f3dbd56efd0da9e6e3c50db 256 SUPERFAMILY SSF56349 34 240 1.74E-10 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS00160 5014e4fc1f3dbd56efd0da9e6e3c50db 256 Pfam PF00589 Phage integrase family 164 247 6.7E-6 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS00160 5014e4fc1f3dbd56efd0da9e6e3c50db 256 Gene3D G3DSA:1.10.443.10 166 238 1.4E-8 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 36 198 2.4E-22 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 Gene3D G3DSA:1.10.1740.10 23 137 3.2E-14 T 17-03-2017 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 Pfam PF08281 Sigma-70, region 4 148 197 6.6E-12 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 SUPERFAMILY SSF88946 23 127 2.94E-14 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 SUPERFAMILY SSF88659 128 201 2.24E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 Pfam PF04542 Sigma-70 region 2 42 110 3.9E-9 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31570 1a53af2f1861c645373ca957a4b5e537 203 Gene3D G3DSA:1.10.10.10 144 201 5.3E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38675 b520709d46500760966bca050690f441 222 Gene3D G3DSA:1.10.357.10 2 189 1.5E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS38675 b520709d46500760966bca050690f441 222 SUPERFAMILY SSF48498 78 189 1.62E-16 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS38675 b520709d46500760966bca050690f441 222 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 58 1.4E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38675 b520709d46500760966bca050690f441 222 SUPERFAMILY SSF46689 7 74 6.67E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35465 4bb66af80cfd3fcd26e4c4627c7d18a4 329 Pfam PF12840 Helix-turn-helix domain 265 311 5.0E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35465 4bb66af80cfd3fcd26e4c4627c7d18a4 329 SUPERFAMILY SSF46785 270 326 1.72E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35465 4bb66af80cfd3fcd26e4c4627c7d18a4 329 SMART SM00418 262 326 0.0032 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS35465 4bb66af80cfd3fcd26e4c4627c7d18a4 329 Gene3D G3DSA:1.10.10.10 267 321 3.2E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44305 f5ee723ba39d93c00c0887948f6c3822 146 SUPERFAMILY SSF55961 1 146 2.24E-29 T 17-03-2017 SHXM_RS44305 f5ee723ba39d93c00c0887948f6c3822 146 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 5 144 6.3E-17 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS44305 f5ee723ba39d93c00c0887948f6c3822 146 Gene3D G3DSA:3.30.530.20 5 145 1.9E-17 T 17-03-2017 IPR023393 START-like domain SHXM_RS32775 51b9e21b636ed75240e6cb3662543887 326 Pfam PF00487 Fatty acid desaturase 62 280 6.2E-21 T 17-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 SHXM_RS32775 51b9e21b636ed75240e6cb3662543887 326 PRINTS PR00075 Fatty acid desaturase family 1 signature 264 278 3.2E-16 T 17-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 SHXM_RS32775 51b9e21b636ed75240e6cb3662543887 326 PRINTS PR00075 Fatty acid desaturase family 1 signature 84 104 3.2E-16 T 17-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 SHXM_RS32775 51b9e21b636ed75240e6cb3662543887 326 PRINTS PR00075 Fatty acid desaturase family 1 signature 61 83 3.2E-16 T 17-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 SHXM_RS32775 51b9e21b636ed75240e6cb3662543887 326 PRINTS PR00075 Fatty acid desaturase family 1 signature 221 242 3.2E-16 T 17-03-2017 IPR015876 Fatty acid desaturase, type 1, core GO:0016717|GO:0055114 Reactome: R-HSA-75105 SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 SUPERFAMILY SSF46785 19 155 5.91E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 SMART SM00347 38 140 1.1E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 Gene3D G3DSA:1.10.10.10 19 155 9.8E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 PRINTS PR00598 Bacterial regulatory protein MarR family signature 103 119 8.4E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 PRINTS PR00598 Bacterial regulatory protein MarR family signature 84 99 8.4E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 PRINTS PR00598 Bacterial regulatory protein MarR family signature 67 83 8.4E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27905 7a91ef0e8e67f1dc3f9b8f4c8c2a7892 158 Pfam PF01047 MarR family 65 107 1.5E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 2 177 5.0E-4 T 17-03-2017 SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 6.4E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 118 134 6.4E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 6.4E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 144 163 6.4E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 182 6.4E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 131 159 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 Gene3D G3DSA:3.40.50.720 5 216 2.3E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 SUPERFAMILY SSF51735 3 216 6.16E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36070 389c756271ef2a2e4c31e419fb16080f 229 Pfam PF00106 short chain dehydrogenase 5 189 8.5E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 SUPERFAMILY SSF81665 604 620 2.48E-12 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 SUPERFAMILY SSF81665 52 118 2.48E-12 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 SUPERFAMILY SSF81665 221 312 2.48E-12 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 389 617 7.0E-42 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 87 355 7.2E-30 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 Pfam PF00122 E1-E2 ATPase 87 309 3.9E-41 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 SUPERFAMILY SSF56784 409 584 5.57E-39 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 SUPERFAMILY SSF56784 317 336 5.57E-39 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 Pfam PF00702 haloacid dehalogenase-like hydrolase 315 548 3.5E-31 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 Gene3D G3DSA:3.40.1110.10 329 461 2.7E-48 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 320 326 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 Hamap MF_00285 Potassium-transporting ATPase ATP-binding subunit [kdpB]. 29 698 40.836 T 17-03-2017 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 557 569 3.4E-25 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 534 553 3.4E-25 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 167 181 3.4E-25 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 318 332 3.4E-25 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 481 491 3.4E-25 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 SUPERFAMILY SSF81653 129 220 8.11E-20 T 17-03-2017 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 Gene3D G3DSA:2.70.150.10 57 221 1.1E-22 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 TIGRFAM TIGR01497 kdpB: K+-transporting ATPase, B subunit 28 694 0.0 T 17-03-2017 IPR006391 P-type ATPase, B chain, subfamily IA GO:0005524|GO:0006813|GO:0008556|GO:0016021 SHXM_RS16165 ff85a06daeccca097d5e403bafff32c1 701 Gene3D G3DSA:3.40.50.1000 462 581 1.6E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS06930 5ea3b140925b9d3a2d46f4e6855dd79b 371 Pfam PF09362 Domain of unknown function (DUF1996) 114 329 3.7E-45 T 17-03-2017 IPR018535 Domain of unknown function DUF1996 SHXM_RS33240 99088babb9ad44569822b993d61dc1d8 285 Gene3D G3DSA:3.40.50.720 1 275 9.8E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33240 99088babb9ad44569822b993d61dc1d8 285 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 203 1.1E-13 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS33240 99088babb9ad44569822b993d61dc1d8 285 SUPERFAMILY SSF51735 1 276 4.95E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23870 9f1c9244c792a60fe4982fc2e7e623b1 445 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 126 138 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS23870 9f1c9244c792a60fe4982fc2e7e623b1 445 Gene3D G3DSA:3.30.200.20 4 72 2.7E-16 T 17-03-2017 SHXM_RS23870 9f1c9244c792a60fe4982fc2e7e623b1 445 SUPERFAMILY SSF56112 6 282 4.51E-64 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS23870 9f1c9244c792a60fe4982fc2e7e623b1 445 SMART SM00220 9 286 2.3E-62 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS23870 9f1c9244c792a60fe4982fc2e7e623b1 445 Pfam PF00069 Protein kinase domain 9 278 2.7E-43 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS23870 9f1c9244c792a60fe4982fc2e7e623b1 445 Gene3D G3DSA:1.10.510.10 73 279 2.9E-44 T 17-03-2017 SHXM_RS20510 a3f36dc4507b37d610792df3a1ba2fb9 263 Pfam PF08787 Alginate lyase 45 262 1.4E-57 T 17-03-2017 IPR014895 Alginate lyase 2 SHXM_RS20510 a3f36dc4507b37d610792df3a1ba2fb9 263 Gene3D G3DSA:2.60.120.200 36 262 5.4E-63 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS20510 a3f36dc4507b37d610792df3a1ba2fb9 263 SUPERFAMILY SSF49899 45 262 2.02E-58 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Pfam PF00931 NB-ARC domain 237 472 3.1E-8 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 PRINTS PR00364 Disease resistance protein signature 239 254 7.0E-7 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 PRINTS PR00364 Disease resistance protein signature 315 329 7.0E-7 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 PRINTS PR00364 Disease resistance protein signature 399 413 7.0E-7 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Gene3D G3DSA:1.25.40.10 1126 1196 1.3E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Pfam PF13424 Tetratricopeptide repeat 889 954 3.3E-7 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Pfam PF13424 Tetratricopeptide repeat 1127 1192 1.8E-9 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Gene3D G3DSA:3.40.50.300 226 330 2.5E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Gene3D G3DSA:3.10.450.50 1510 1534 2.9E-4 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SUPERFAMILY SSF81901 1122 1214 1.1E-13 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SUPERFAMILY SSF81901 849 959 1.1E-13 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SUPERFAMILY SSF81901 1045 1078 1.1E-13 T 17-03-2017 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Gene3D G3DSA:1.25.40.10 617 815 1.9E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 887 920 0.58 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 649 682 160.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 729 757 170.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 1126 1159 5.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 847 880 390.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 1166 1199 110.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 1007 1040 11.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 927 960 9.1 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00028 1047 1080 0.34 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SUPERFAMILY SSF52540 209 465 6.14E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SMART SM00382 236 388 0.0027 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SUPERFAMILY SSF48452 638 760 2.15E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 SUPERFAMILY SSF48452 926 1104 5.8E-22 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Gene3D G3DSA:1.25.40.10 831 973 1.2E-16 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15745 1cb8ea3f4e25ca88104099e402dcfabd 1537 Gene3D G3DSA:1.25.40.10 974 1104 3.3E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS00875 bc919c192dfbd92cdf44363ecf78b6c0 472 Pfam PF00652 Ricin-type beta-trefoil lectin domain 39 162 7.5E-29 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS00875 bc919c192dfbd92cdf44363ecf78b6c0 472 Pfam PF03664 Glycosyl hydrolase family 62 173 442 2.1E-159 T 17-03-2017 IPR005193 Glycoside hydrolase, family 62, arabinosidase GO:0046373|GO:0046556 KEGG: 00520+3.2.1.55 SHXM_RS00875 bc919c192dfbd92cdf44363ecf78b6c0 472 SUPERFAMILY SSF75005 192 460 9.07E-31 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS00875 bc919c192dfbd92cdf44363ecf78b6c0 472 SMART SM00458 39 165 2.5E-34 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS00875 bc919c192dfbd92cdf44363ecf78b6c0 472 Gene3D G3DSA:2.80.10.50 41 163 1.9E-42 T 17-03-2017 SHXM_RS00875 bc919c192dfbd92cdf44363ecf78b6c0 472 SUPERFAMILY SSF50370 36 163 1.4E-41 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 Gene3D G3DSA:1.20.1250.20 493 516 1.3E-21 T 17-03-2017 SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 Gene3D G3DSA:1.20.1250.20 35 208 1.0E-36 T 17-03-2017 SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 Gene3D G3DSA:1.20.1250.20 283 446 1.3E-21 T 17-03-2017 SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 SUPERFAMILY SSF103473 34 222 5.14E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 SUPERFAMILY SSF103473 488 516 5.14E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 SUPERFAMILY SSF103473 269 440 5.14E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 Gene3D G3DSA:1.10.10.10 566 672 3.8E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 SUPERFAMILY SSF46785 566 668 5.0E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 Pfam PF07690 Major Facilitator Superfamily 38 430 1.3E-51 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS19975 183452cc2ef072279d774a3dc463dd10 697 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 33 511 6.7E-85 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 Gene3D G3DSA:3.40.50.300 110 134 4.2E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 Gene3D G3DSA:3.40.50.300 19 67 4.2E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 ProSitePatterns PS00622 LuxR-type HTH domain signature. 887 914 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 Pfam PF00196 Bacterial regulatory proteins, luxR family 872 923 3.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 SUPERFAMILY SSF48452 581 707 4.74E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 Gene3D G3DSA:1.25.40.10 529 845 6.2E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 SMART SM00421 870 927 3.2E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 887 903 1.2E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 873 887 1.2E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 903 915 1.2E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 Gene3D G3DSA:1.10.10.10 866 923 5.7E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 Pfam PF13191 AAA ATPase domain 1 144 2.6E-12 T 17-03-2017 SHXM_RS22105 a4d34621c304b1cdc9b66e6b080c4ab4 935 SUPERFAMILY SSF46894 865 923 1.22E-14 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 Pfam PF00581 Rhodanese-like domain 149 266 1.2E-15 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 Pfam PF00581 Rhodanese-like domain 10 118 1.5E-17 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 Gene3D G3DSA:3.40.250.10 149 275 1.4E-34 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 SUPERFAMILY SSF52821 149 276 3.14E-34 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 ProSitePatterns PS00683 Rhodanese C-terminal signature. 255 265 - T 17-03-2017 IPR001307 Thiosulphate sulfurtransferase, conserved site GO:0004792 KEGG: 00920+2.8.1.1|MetaCyc: PWY-5350 SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 SMART SM00450 8 122 1.0E-20 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 SMART SM00450 144 271 8.2E-21 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 Gene3D G3DSA:3.40.250.10 4 140 4.3E-38 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS30090 eb59d3076a48d5e7128c5ef9160933d0 279 SUPERFAMILY SSF52821 4 140 1.57E-36 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS05890 7694b7d421eb18b01299d082e842b218 259 Pfam PF08241 Methyltransferase domain 52 142 1.7E-21 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS05890 7694b7d421eb18b01299d082e842b218 259 Gene3D G3DSA:3.40.50.150 24 149 2.0E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS05890 7694b7d421eb18b01299d082e842b218 259 SUPERFAMILY SSF53335 29 153 3.0E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 8 198 1.9E-4 T 17-03-2017 SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 SUPERFAMILY SSF51735 5 248 8.7E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 Gene3D G3DSA:3.40.50.720 4 256 1.0E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 4.8E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 207 227 4.8E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 139 155 4.8E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 164 183 4.8E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 4.8E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 4.8E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31655 b585a94e471d8e1de1c7b6a14b78fd7f 303 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 241 3.3E-37 T 17-03-2017 SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 SMART SM00448 11 124 3.1E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 SUPERFAMILY SSF52172 12 135 1.24E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 SUPERFAMILY SSF46785 173 216 7.0E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 Pfam PF00072 Response regulator receiver domain 13 124 2.4E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 Pfam PF08279 HTH domain 176 215 2.1E-6 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 Gene3D G3DSA:1.10.10.10 176 215 4.0E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 PIRSF PIRSF006171 10 233 5.1E-78 T 17-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 SHXM_RS37490 efb46a115032ae8131a8227fbad707ff 233 Gene3D G3DSA:3.40.50.2300 12 134 2.0E-30 T 17-03-2017 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SUPERFAMILY SSF55781 299 437 1.57E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Pfam PF13185 GAF domain 298 433 2.6E-10 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 679 869 3.6E-42 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Gene3D G3DSA:3.30.450.20 158 252 1.4E-12 T 17-03-2017 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Gene3D G3DSA:3.30.450.40 297 439 1.3E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 158 251 1.2E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SMART SM00065 463 631 0.023 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SMART SM00065 298 442 1.5E-11 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SUPERFAMILY SSF81606 661 869 2.2E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Pfam PF13492 GAF domain 572 623 3.2E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SUPERFAMILY SSF55781 448 629 1.81E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SMART SM00091 148 214 1.3E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SUPERFAMILY SSF55785 158 252 2.97E-16 T 17-03-2017 IPR000014 PAS domain SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SUPERFAMILY SSF55874 38 129 3.78E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Pfam PF00989 PAS fold 158 197 1.5E-8 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Gene3D G3DSA:3.30.450.40 452 629 3.5E-22 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 Pfam PF13581 Histidine kinase-like ATPase domain 15 127 1.3E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37145 574a214c1fe940e42592055605e8f081 875 SMART SM00331 652 869 7.3E-66 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS18595 473f40eec4ba43392131fba92687176f 660 Gene3D G3DSA:3.40.710.10 301 635 5.9E-84 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS18595 473f40eec4ba43392131fba92687176f 660 Gene3D G3DSA:3.90.1310.10 213 300 3.5E-25 T 17-03-2017 SHXM_RS18595 473f40eec4ba43392131fba92687176f 660 Pfam PF00905 Penicillin binding protein transpeptidase domain 319 634 8.2E-69 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS18595 473f40eec4ba43392131fba92687176f 660 SUPERFAMILY SSF56519 105 291 9.94E-35 T 17-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SHXM_RS18595 473f40eec4ba43392131fba92687176f 660 SUPERFAMILY SSF56601 294 645 1.36E-80 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS18595 473f40eec4ba43392131fba92687176f 660 Pfam PF03717 Penicillin-binding Protein dimerisation domain 108 270 1.0E-17 T 17-03-2017 IPR005311 Penicillin-binding protein, dimerisation domain GO:0008658 SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 65 216 2.0E-12 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 Gene3D G3DSA:3.40.47.10 3 216 1.4E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 Gene3D G3DSA:3.40.47.10 230 374 2.0E-38 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 SMART SM00825 Beta-ketoacyl synthase 3 375 3.6E-11 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 221 333 1.9E-24 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 SUPERFAMILY SSF53901 184 374 2.08E-43 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02135 91c83292f23655d4dce5e2e473c582c8 378 SUPERFAMILY SSF53901 3 216 1.89E-27 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05495 190d649767053d81338e0ecb5a073fce 263 Pfam PF13622 Thioesterase-like superfamily 23 257 6.9E-25 T 17-03-2017 SHXM_RS00780 b1f3f935a3327b7aa073dae25c32bc04 361 Pfam PF13683 Integrase core domain 262 327 8.2E-15 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS00780 b1f3f935a3327b7aa073dae25c32bc04 361 SUPERFAMILY SSF46689 73 155 6.63E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00780 b1f3f935a3327b7aa073dae25c32bc04 361 Gene3D G3DSA:3.30.420.10 172 327 2.0E-11 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00780 b1f3f935a3327b7aa073dae25c32bc04 361 SUPERFAMILY SSF53098 174 328 2.28E-16 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 SMART SM00220 26 281 1.1E-58 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 Gene3D G3DSA:1.10.510.10 94 275 1.3E-44 T 17-03-2017 SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 Pfam PF00069 Protein kinase domain 26 274 1.0E-47 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 Gene3D G3DSA:3.30.200.20 21 93 1.2E-23 T 17-03-2017 SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 SUPERFAMILY SSF56112 327 352 1.14E-68 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 SUPERFAMILY SSF56112 22 281 1.14E-68 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS32045 4ac5a04414a6da2a971431c8def1e693 571 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 32 55 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 Pfam PF01515 Phosphate acetyl/butaryl transferase 366 683 3.3E-127 T 17-03-2017 IPR002505 Phosphate acetyl/butaryl transferase GO:0008152|GO:0016746 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 TIGRFAM TIGR00651 pta: phosphate acetyltransferase 382 683 8.7E-123 T 17-03-2017 IPR004614 Phosphate acetyltransferase GO:0016407 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 Pfam PF07085 DRTGG domain 209 319 1.3E-22 T 17-03-2017 IPR010766 DRTGG KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 PIRSF PIRSF006107 1 691 5.6E-180 T 17-03-2017 IPR016475 Phosphate acetyltransferase, bacteria GO:0008959 KEGG: 00430+2.3.1.8|KEGG: 00620+2.3.1.8|KEGG: 00640+2.3.1.8|KEGG: 00680+2.3.1.8|KEGG: 00720+2.3.1.8|MetaCyc: PWY-1281|MetaCyc: PWY-5482|MetaCyc: PWY-5485|MetaCyc: PWY-5497|MetaCyc: PWY-6637 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 Gene3D G3DSA:3.40.50.300 3 205 1.6E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 Gene3D G3DSA:3.40.50.10750 501 659 1.9E-67 T 17-03-2017 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 SUPERFAMILY SSF52540 4 216 8.92E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 Gene3D G3DSA:3.40.1390.20 206 342 1.0E-26 T 17-03-2017 IPR028979 HPr(Ser) kinase/phosphorylase, N-terminal domain-like SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 SUPERFAMILY SSF53659 365 686 6.17E-96 T 17-03-2017 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 Pfam PF13500 AAA domain 3 205 7.3E-19 T 17-03-2017 SHXM_RS35530 7225a3e187e64cc1e62d28b8152b7635 699 SUPERFAMILY SSF75138 204 322 2.94E-20 T 17-03-2017 IPR028979 HPr(Ser) kinase/phosphorylase, N-terminal domain-like SHXM_RS23440 1b7538bbbd244c4a9cf3099ca9bdf030 194 SUPERFAMILY SSF52499 2 188 2.35E-48 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS23440 1b7538bbbd244c4a9cf3099ca9bdf030 194 Gene3D G3DSA:3.40.50.850 1 188 7.4E-59 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS23440 1b7538bbbd244c4a9cf3099ca9bdf030 194 Pfam PF00857 Isochorismatase family 4 188 2.0E-33 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS18125 958247b705a7f36c15f7d24e5ecd4d2f 586 Pfam PF13406 Transglycosylase SLT domain 184 228 1.2E-7 T 17-03-2017 IPR031304 Transglycosylase SLT domain 2 SHXM_RS18125 958247b705a7f36c15f7d24e5ecd4d2f 586 SUPERFAMILY SSF53955 96 263 1.08E-37 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS18125 958247b705a7f36c15f7d24e5ecd4d2f 586 Gene3D G3DSA:2.60.40.920 361 457 2.4E-5 T 17-03-2017 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SHXM_RS18125 958247b705a7f36c15f7d24e5ecd4d2f 586 Gene3D G3DSA:1.10.530.10 115 260 1.6E-10 T 17-03-2017 SHXM_RS18125 958247b705a7f36c15f7d24e5ecd4d2f 586 SUPERFAMILY SSF49373 368 447 4.71E-5 T 17-03-2017 IPR008964 Invasin/intimin cell-adhesion fragments SHXM_RS26815 fe72d0680987d900270324a9b82bda53 205 Gene3D G3DSA:3.40.50.150 8 73 8.6E-11 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26815 fe72d0680987d900270324a9b82bda53 205 SUPERFAMILY SSF53335 10 187 5.53E-17 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Gene3D G3DSA:3.30.565.10 389 543 4.8E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 414 544 7.5E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 SMART SM00387 413 545 1.2E-25 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 SUPERFAMILY SSF55785 218 272 6.81E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Pfam PF00989 PAS fold 216 265 5.9E-6 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Gene3D G3DSA:3.30.450.20 34 170 1.4E-42 T 17-03-2017 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 PRINTS PR00344 Bacterial sensor protein C-terminal signature 454 468 9.4E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 PRINTS PR00344 Bacterial sensor protein C-terminal signature 505 523 9.4E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 PRINTS PR00344 Bacterial sensor protein C-terminal signature 529 542 9.4E-13 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Gene3D G3DSA:1.10.287.130 309 367 1.3E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Pfam PF17203 Single cache domain 3 38 170 8.7E-22 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 SUPERFAMILY SSF55890 318 367 1.01E-7 T 17-03-2017 IPR016120 Signal transduction histidine kinase, sporulation regulator SpoOB GO:0000155|GO:0000160|GO:0016772 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Pfam PF14689 Sensor_kinase_SpoOB-type, alpha-helical domain 318 367 2.7E-8 T 17-03-2017 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 SUPERFAMILY SSF103190 38 169 2.86E-29 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 SMART SM00091 215 280 9.1E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 Gene3D G3DSA:3.30.450.20 216 308 1.1E-7 T 17-03-2017 SHXM_RS03420 00a8eb3f4bf7bb4dbe5666cf801eb8e5 562 SUPERFAMILY SSF55874 385 542 7.2E-29 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 Pfam PF00817 impB/mucB/samB family 10 158 6.7E-44 T 17-03-2017 IPR001126 UmuC domain GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 Gene3D G3DSA:3.30.70.270 68 168 2.2E-24 T 17-03-2017 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 SUPERFAMILY SSF100879 243 343 1.0E-25 T 17-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 Hamap MF_01113 DNA polymerase IV [dinB]. 4 352 35.097 T 17-03-2017 IPR022880 DNA polymerase IV GO:0003887 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5655862|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 Pfam PF11799 impB/mucB/samB family C-terminal domain 241 346 2.4E-20 T 17-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 Gene3D G3DSA:1.10.150.20 170 239 1.5E-19 T 17-03-2017 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 Gene3D G3DSA:3.30.1490.100 246 352 4.2E-29 T 17-03-2017 IPR017961 DNA polymerase, Y-family, little finger domain GO:0003684|GO:0006281 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7|Reactome: R-HSA-5656169 SHXM_RS43955 1c1f65a446877e76193b4b7ee0a308b3 504 SUPERFAMILY SSF56672 6 239 3.56E-71 T 17-03-2017 SHXM_RS39900 9d0d3945334ac8fed845dceace874eb1 298 SMART SM00530 10 87 2.0E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS39900 9d0d3945334ac8fed845dceace874eb1 298 Gene3D G3DSA:1.10.260.40 8 86 4.5E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39900 9d0d3945334ac8fed845dceace874eb1 298 SUPERFAMILY SSF47413 35 84 1.62E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39900 9d0d3945334ac8fed845dceace874eb1 298 Pfam PF13560 Helix-turn-helix domain 13 90 7.8E-13 T 17-03-2017 SHXM_RS04885 31afcf6c8ec105bf5e5c549b42501089 315 SUPERFAMILY SSF56529 74 284 1.06E-29 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS04885 31afcf6c8ec105bf5e5c549b42501089 315 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 105 283 5.3E-18 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS04885 31afcf6c8ec105bf5e5c549b42501089 315 Gene3D G3DSA:3.90.850.10 105 285 2.8E-29 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 24 216 3.0E-41 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 170 189 8.2E-20 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 121 133 8.2E-20 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 38 54 8.2E-20 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 Pfam PF00717 Peptidase S24-like 45 87 1.3E-11 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 ProSitePatterns PS00761 Signal peptidases I signature 3. 175 188 - T 17-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 Gene3D G3DSA:2.10.109.10 34 131 1.5E-39 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 Gene3D G3DSA:2.10.109.10 170 221 1.5E-39 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 SUPERFAMILY SSF51306 116 221 3.03E-49 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS36605 e42d66a061f3d735aea04018c032ea38 278 SUPERFAMILY SSF51306 37 85 3.03E-49 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 ProSitePatterns PS01081 TetR-type HTH domain signature. 34 63 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 SUPERFAMILY SSF48498 89 206 4.15E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 SUPERFAMILY SSF46689 12 86 1.28E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 4.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 4.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 Gene3D G3DSA:1.10.357.10 5 204 5.7E-48 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS08385 4eca026cbae8166fa90fc6bf62d9f511 218 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 67 2.2E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 Pfam PF01476 LysM domain 177 224 2.4E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 SUPERFAMILY SSF51261 287 405 3.03E-43 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 SUPERFAMILY SSF54106 176 224 2.09E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 Gene3D G3DSA:1.10.530.10 23 123 1.9E-42 T 17-03-2017 SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 Gene3D G3DSA:3.10.350.10 175 225 3.2E-10 T 17-03-2017 IPR018392 LysM domain SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 SMART SM00257 176 225 1.7E-8 T 17-03-2017 IPR018392 LysM domain SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 Pfam PF01551 Peptidase family M23 304 401 1.8E-29 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 Pfam PF06737 Transglycosylase-like domain 42 117 5.2E-35 T 17-03-2017 IPR010618 Transglycosylase-like SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 Gene3D G3DSA:2.70.70.10 260 406 1.2E-42 T 17-03-2017 SHXM_RS45005 4d73b0423714fad7826ac840961f8b7d 412 SUPERFAMILY SSF53955 42 123 1.67E-32 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS25800 a03bb9efaf02e88383f290b714c4b7fe 139 SUPERFAMILY SSF54593 1 120 6.98E-27 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS25800 a03bb9efaf02e88383f290b714c4b7fe 139 Gene3D G3DSA:3.10.180.10 1 121 5.8E-34 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS25800 a03bb9efaf02e88383f290b714c4b7fe 139 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 118 9.4E-15 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS06065 4dac3548261619d534ed20802d8c0fb8 395 Pfam PF03417 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase 147 341 5.1E-10 T 17-03-2017 IPR005079 Peptidase C45 SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 SMART SM00065 205 349 6.4E-12 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 SMART SM00065 47 185 4.0E-11 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Gene3D G3DSA:3.30.450.40 213 339 5.5E-17 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Gene3D G3DSA:3.30.565.10 456 543 2.4E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Pfam PF13185 GAF domain 47 175 8.8E-14 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Pfam PF13185 GAF domain 213 339 1.1E-12 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 SUPERFAMILY SSF55781 212 339 5.45E-18 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Pfam PF07730 Histidine kinase 357 418 2.3E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Gene3D G3DSA:3.30.450.40 30 189 3.7E-17 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 SUPERFAMILY SSF55781 31 199 1.33E-21 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 SUPERFAMILY SSF55874 457 558 4.45E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 SMART SM00387 461 560 3.1E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27785 420d6ca24b2b7c354c444e3811e6b6be 563 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 465 540 1.6E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01835 c8bd2397886affd7658fb1d338402bcb 758 SUPERFAMILY SSF75005 21 353 6.15E-68 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS01835 c8bd2397886affd7658fb1d338402bcb 758 Gene3D G3DSA:2.115.10.20 31 354 3.9E-74 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS01835 c8bd2397886affd7658fb1d338402bcb 758 SUPERFAMILY SSF49899 572 756 3.17E-6 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS01835 c8bd2397886affd7658fb1d338402bcb 758 Pfam PF04616 Glycosyl hydrolases family 43 47 352 5.8E-54 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 SUPERFAMILY SSF52151 180 280 2.88E-59 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 SUPERFAMILY SSF52151 1 115 2.88E-59 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 Gene3D G3DSA:3.40.366.10 1 109 4.7E-63 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 Gene3D G3DSA:3.40.366.10 179 286 4.7E-63 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 Gene3D G3DSA:3.30.70.250 114 178 8.0E-10 T 17-03-2017 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 SUPERFAMILY SSF55048 115 179 4.58E-15 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1 288 1.5E-105 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS16720 ad353a15fcefeff3fbba64e206852bc6 305 Pfam PF00698 Acyl transferase domain 1 301 8.7E-80 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS23175 d37c7cc69ab058c6e967c661a3fb467f 273 Gene3D G3DSA:1.10.10.10 214 269 8.1E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23175 d37c7cc69ab058c6e967c661a3fb467f 273 SMART SM00421 214 263 0.0034 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS23175 d37c7cc69ab058c6e967c661a3fb467f 273 SUPERFAMILY SSF46894 214 269 2.04E-8 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 SMART SM00968 512 903 2.3E-17 T 17-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 Pfam PF06470 SMC proteins Flexible Hinge Domain 513 576 8.2E-11 T 17-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 SUPERFAMILY SSF52540 2 207 3.48E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 SUPERFAMILY SSF52540 1265 1455 3.48E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 Hamap MF_01894 Chromosome partition protein Smc [smc]. 1 1464 22.299 T 17-03-2017 IPR011890 Structural maintenance of chromosomes protein, prokaryotic GO:0007062|GO:0030261 SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 Pfam PF02463 RecF/RecN/SMC N terminal domain 3 1456 2.2E-71 T 17-03-2017 IPR003395 RecF/RecN/SMC, N-terminal SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 SUPERFAMILY SSF75553 862 948 4.18E-7 T 17-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 Gene3D G3DSA:3.40.50.300 1312 1459 2.5E-87 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 Gene3D G3DSA:3.40.50.300 2 163 2.5E-87 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36485 c16a74e27e74c4d74e06be42bd7d150f 1464 SUPERFAMILY SSF75553 498 574 1.44E-10 T 17-03-2017 IPR010935 SMCs flexible hinge GO:0005515|GO:0005524|GO:0005694|GO:0051276 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 SUPERFAMILY SSF88946 36 114 1.7E-24 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 Pfam PF04542 Sigma-70 region 2 46 114 1.5E-15 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 SUPERFAMILY SSF88659 118 194 3.79E-10 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 SUPERFAMILY SSF88659 184 262 1.25E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 Gene3D G3DSA:1.10.10.10 114 168 4.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 PRINTS PR00046 Major sigma-70 factor signature 216 228 3.7E-6 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 PRINTS PR00046 Major sigma-70 factor signature 233 248 3.7E-6 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 PRINTS PR00046 Major sigma-70 factor signature 69 82 3.7E-6 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 41 261 2.1E-31 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 Gene3D G3DSA:1.10.10.10 205 263 1.9E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 Pfam PF04545 Sigma-70, region 4 212 259 1.5E-16 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 Gene3D G3DSA:1.10.601.10 37 112 4.9E-17 T 17-03-2017 SHXM_RS03215 e07ea501116d63eb78a993b6f607bc78 268 TIGRFAM TIGR02980 SigBFG: RNA polymerase sigma-70 factor, sigma-B/F/G subfamily 39 262 6.2E-84 T 17-03-2017 IPR014322 RNA polymerase sigma-B/F/G type GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 SUPERFAMILY SSF51445 56 324 9.94E-83 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 SUPERFAMILY SSF51445 384 421 9.94E-83 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 Gene3D G3DSA:3.20.20.80 52 327 4.4E-87 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 Gene3D G3DSA:3.20.20.80 391 424 4.4E-87 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 Gene3D G3DSA:3.10.50.10 328 386 4.5E-25 T 17-03-2017 IPR029070 Chitinase insertion domain SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 SMART SM00636 60 414 5.7E-113 T 17-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 Pfam PF00704 Glycosyl hydrolases family 18 61 414 1.2E-74 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 SUPERFAMILY SSF54556 326 385 4.79E-15 T 17-03-2017 IPR029070 Chitinase insertion domain SHXM_RS11590 05f0f766d6d3141a46af762a58800fb0 425 ProSitePatterns PS01095 Chitinases family 18 active site. 195 203 - T 17-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 Gene3D G3DSA:1.10.3860.10 21 418 1.1E-107 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 SUPERFAMILY SSF118215 25 413 5.36E-101 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 65 85 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 205 224 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 307 333 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 23 43 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 342 361 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 95 120 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 PRINTS PR00173 Glutamate-aspartate symporter signature 368 388 3.7E-27 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS30670 f12df185e0a5e3789b8830b657187e58 444 Pfam PF00375 Sodium:dicarboxylate symporter family 25 412 1.3E-110 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 SUPERFAMILY SSF46955 11 83 1.36E-17 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 Gene3D G3DSA:1.10.1660.10 12 131 1.6E-19 T 17-03-2017 SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 47 67 6.2E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 12 23 6.2E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 23 36 6.2E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 Pfam PF13411 MerR HTH family regulatory protein 12 79 3.4E-18 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13510 e5cb26f57762b37d212880eca7f2f596 247 SMART SM00422 11 80 3.5E-20 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS13480 e1888dd200176abd1d492dea6f131ca6 578 Pfam PF02028 BCCT, betaine/carnitine/choline family transporter 21 511 4.6E-173 T 17-03-2017 IPR000060 BCCT transporter family GO:0005215|GO:0006810|GO:0016020 SHXM_RS13480 e1888dd200176abd1d492dea6f131ca6 578 ProSitePatterns PS01303 BCCT family of transporters signature. 328 337 - T 17-03-2017 IPR018093 BCCT transporter, conserved site GO:0005215|GO:0006810|GO:0016020 SHXM_RS13480 e1888dd200176abd1d492dea6f131ca6 578 TIGRFAM TIGR00842 bcct: transporter, betaine/carnitine/choline transporter (BCCT) family 59 511 1.2E-158 T 17-03-2017 IPR000060 BCCT transporter family GO:0005215|GO:0006810|GO:0016020 SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 ProSitePatterns PS00519 AsnC-type HTH domain signature. 21 47 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 Gene3D G3DSA:1.10.10.10 5 55 4.7E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 SUPERFAMILY SSF54909 65 143 8.71E-14 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 SMART SM00344 3 110 5.1E-30 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 Pfam PF01037 Lrp/AsnC ligand binding domain 73 139 6.0E-15 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 Gene3D G3DSA:3.30.70.920 56 135 2.4E-19 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 SUPERFAMILY SSF46785 2 63 3.06E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 Pfam PF13404 AsnC-type helix-turn-helix domain 3 44 2.7E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 30 49 1.0E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 3 19 1.0E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS12240 dd7965773efe6a3413c4373ecac14817 151 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 19 30 1.0E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS45055 539d86e5f15c40cfa303295e55c0fac8 462 SUPERFAMILY SSF51206 83 205 5.5E-20 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS45055 539d86e5f15c40cfa303295e55c0fac8 462 Gene3D G3DSA:2.60.120.10 87 210 1.4E-18 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS45055 539d86e5f15c40cfa303295e55c0fac8 462 Pfam PF00027 Cyclic nucleotide-binding domain 110 196 1.7E-14 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS45055 539d86e5f15c40cfa303295e55c0fac8 462 SMART SM00100 90 213 7.6E-10 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 Gene3D G3DSA:1.10.1660.10 1 87 1.2E-14 T 17-03-2017 SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 SUPERFAMILY SSF46955 1 78 2.01E-11 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 1.4E-5 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 37 57 1.4E-5 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 1.4E-5 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 SMART SM00422 1 71 3.0E-5 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36340 30b7d1e0c22e38849115271a749eec73 213 Pfam PF13411 MerR HTH family regulatory protein 1 70 1.6E-13 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS03690 33508864b180245db1619e0693b6d508 177 SUPERFAMILY SSF160904 6 169 1.57E-28 T 17-03-2017 SHXM_RS03690 33508864b180245db1619e0693b6d508 177 Pfam PF11706 CGNR zinc finger 132 169 1.5E-9 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS03690 33508864b180245db1619e0693b6d508 177 Gene3D G3DSA:1.10.3300.10 9 170 2.6E-32 T 17-03-2017 IPR023286 ABATE domain SHXM_RS26935 b23119a5250d539543be5a45474c81b6 278 TIGRFAM TIGR01490 HAD-SF-IB-hyp1: HAD hydrolase, family IB 14 213 4.1E-61 T 17-03-2017 IPR006385 HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial SHXM_RS26935 b23119a5250d539543be5a45474c81b6 278 Gene3D G3DSA:3.40.50.1000 86 236 1.1E-49 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS26935 b23119a5250d539543be5a45474c81b6 278 Pfam PF12710 haloacid dehalogenase-like hydrolase 15 200 1.6E-31 T 17-03-2017 SHXM_RS26935 b23119a5250d539543be5a45474c81b6 278 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 14 202 6.8E-22 T 17-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 SHXM_RS26935 b23119a5250d539543be5a45474c81b6 278 SUPERFAMILY SSF56784 11 228 1.03E-30 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS00200 eb793e2c00cef5fb9e9e6ae34197753c 144 SMART SM00857 1 80 0.0071 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS00200 eb793e2c00cef5fb9e9e6ae34197753c 144 SUPERFAMILY SSF46689 82 125 3.2E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00200 eb793e2c00cef5fb9e9e6ae34197753c 144 SUPERFAMILY SSF53041 1 79 8.37E-20 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS00200 eb793e2c00cef5fb9e9e6ae34197753c 144 Pfam PF00239 Resolvase, N terminal domain 1 79 3.7E-20 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS00200 eb793e2c00cef5fb9e9e6ae34197753c 144 Gene3D G3DSA:1.10.10.60 78 139 2.1E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00200 eb793e2c00cef5fb9e9e6ae34197753c 144 Gene3D G3DSA:1.20.5.40 40 77 1.1E-16 T 17-03-2017 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 PIRSF PIRSF029271 7 306 1.5E-150 T 17-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 ProSitePatterns PS01235 PdxS/SNZ family signature. 217 235 - T 17-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 Pfam PF01680 SOR/SNZ family 19 224 2.4E-106 T 17-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 SUPERFAMILY SSF51366 30 276 1.08E-61 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 TIGRFAM TIGR00343 TIGR00343: pyridoxal 5'-phosphate synthase, synthase subunit Pdx1 21 306 7.8E-141 T 17-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 Hamap MF_01824 Pyridoxal 5'-phosphate synthase subunit PdxS [pdxS]. 16 306 51.948 T 17-03-2017 IPR001852 Pyridoxal 5'-phosphate synthase subunit PdxS/SNZ GO:0042819|GO:0042823 KEGG: 00750+4.3.3.6|MetaCyc: PWY-6466 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 Gene3D G3DSA:3.20.20.70 204 290 7.7E-46 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS12565 e5b2c630e03e3e191f834f83739e7801 306 Gene3D G3DSA:3.20.20.70 36 172 7.7E-46 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 Gene3D G3DSA:3.40.50.10540 325 415 2.2E-105 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 Gene3D G3DSA:3.40.50.10540 7 220 2.2E-105 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 SUPERFAMILY SSF89796 10 415 9.94E-119 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 Gene3D G3DSA:3.30.1540.10 240 324 2.4E-22 T 17-03-2017 SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 Hamap MF_00742 Formyl-CoA:oxalate CoA-transferase [frc]. 7 415 63.691 T 17-03-2017 IPR017659 Formyl-CoA:oxalate CoA-transferase GO:0008152|GO:0033608 MetaCyc: PWY-6695 SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 Pfam PF02515 CoA-transferase family III 11 391 2.8E-103 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS14125 162e95c507dd8e69bd12f294e34dca5a 415 TIGRFAM TIGR03253 oxalate_frc: formyl-CoA transferase 9 415 6.9E-209 T 17-03-2017 IPR017659 Formyl-CoA:oxalate CoA-transferase GO:0008152|GO:0033608 MetaCyc: PWY-6695 SHXM_RS33365 0ed4f762cbc5dae98bacd2fcadd44099 397 Pfam PF00294 pfkB family carbohydrate kinase 21 114 4.6E-21 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS33365 0ed4f762cbc5dae98bacd2fcadd44099 397 Pfam PF00294 pfkB family carbohydrate kinase 149 346 6.1E-25 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS33365 0ed4f762cbc5dae98bacd2fcadd44099 397 SUPERFAMILY SSF53613 149 356 4.05E-41 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS33365 0ed4f762cbc5dae98bacd2fcadd44099 397 Gene3D G3DSA:3.40.1190.20 20 361 3.3E-106 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS33365 0ed4f762cbc5dae98bacd2fcadd44099 397 SUPERFAMILY SSF53613 20 114 3.82E-26 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SUPERFAMILY SSF81296 103 189 1.11E-7 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 Pfam PF01833 IPT/TIG domain 195 261 6.7E-10 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 Pfam PF01833 IPT/TIG domain 2 99 6.0E-10 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 Pfam PF01833 IPT/TIG domain 105 188 1.6E-9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SMART SM00429 104 189 4.2E-6 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SMART SM00429 1 100 0.93 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SMART SM00429 194 275 5.6E-9 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SUPERFAMILY SSF81296 61 100 2.87E-7 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SUPERFAMILY SSF81296 2 34 2.87E-7 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 Gene3D G3DSA:2.60.40.10 184 262 3.1E-11 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 SUPERFAMILY SSF81296 193 275 9.67E-10 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 Gene3D G3DSA:2.60.40.10 1 99 1.4E-17 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS34515 5ff033281b86b06920cd39ab779fac33 275 Gene3D G3DSA:2.60.40.10 104 183 1.1E-9 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 Gene3D G3DSA:3.40.190.10 89 193 2.8E-17 T 17-03-2017 SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 Gene3D G3DSA:1.10.10.10 1 83 4.0E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 Pfam PF03466 LysR substrate binding domain 88 293 3.1E-34 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 SUPERFAMILY SSF46785 1 82 1.18E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 4.5E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 4.5E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 4.5E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 9.2E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 SUPERFAMILY SSF53850 89 297 2.17E-34 T 17-03-2017 SHXM_RS02980 41e4c9990be7b450b7ebec266e487721 299 Gene3D G3DSA:3.40.190.10 194 265 4.0E-16 T 17-03-2017 SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 SUPERFAMILY SSF55811 209 347 8.94E-23 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 Pfam PF08241 Methyltransferase domain 51 144 6.7E-25 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 Pfam PF00293 NUDIX domain 213 325 1.5E-14 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 Gene3D G3DSA:3.90.79.10 210 326 1.2E-22 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 SUPERFAMILY SSF53335 8 157 1.24E-40 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 ProSitePatterns PS00893 Nudix box signature. 242 263 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS16610 52243776e8b4e5ad1e0ca0e1fa7bdbe1 367 Gene3D G3DSA:3.40.50.150 8 154 7.3E-37 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 PIRSF PIRSF000538 11 481 3.8E-81 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 Gene3D G3DSA:3.30.420.40 11 254 9.3E-53 T 17-03-2017 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 320 435 1.1E-14 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 TIGRFAM TIGR01312 XylB: xylulokinase 15 473 4.3E-138 T 17-03-2017 IPR006000 Xylulokinase GO:0004856|GO:0005997 KEGG: 00040+2.7.1.17 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 Gene3D G3DSA:3.30.420.40 257 448 2.2E-19 T 17-03-2017 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 13 254 4.5E-66 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 SUPERFAMILY SSF53067 257 475 2.94E-32 T 17-03-2017 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 349 369 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS45080 cb435980e17c868cc170b80c71af48d3 485 SUPERFAMILY SSF53067 13 256 1.12E-53 T 17-03-2017 SHXM_RS00635 023942f27176be3706f7d6c79eda6422 121 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 34 85 4.8E-14 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS00635 023942f27176be3706f7d6c79eda6422 121 Gene3D G3DSA:1.10.10.60 51 74 1.9E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 Pfam PF13354 Beta-lactamase enzyme family 84 291 2.7E-37 T 17-03-2017 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 Gene3D G3DSA:3.40.710.10 64 318 3.4E-100 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 ProSitePatterns PS00146 Beta-lactamase class-A active site. 97 112 - T 17-03-2017 IPR023650 Beta-lactamase, class-A active site KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 SUPERFAMILY SSF56601 64 316 1.27E-74 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 233 248 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 95 112 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 64 88 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 171 195 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 250 265 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 135 160 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS05655 e8b8fe11f7dc5235249167c1f966d5cf 319 PRINTS PR00118 Beta-lactamase class A signature 197 222 5.2E-65 T 17-03-2017 IPR000871 Beta-lactamase, class-A GO:0008800|GO:0030655|GO:0046677 KEGG: 00311+3.5.2.6 SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 Gene3D G3DSA:3.40.50.720 5 246 9.9E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 7.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 7.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 7.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 7.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 7.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 246 2.2E-59 T 17-03-2017 SHXM_RS33015 c734d2a3ac9a657012db443b02969d8d 250 SUPERFAMILY SSF51735 5 246 9.14E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28270 2ad2db1ddfaa8d743a3646d3bd0f2913 280 SUPERFAMILY SSF49879 154 276 4.02E-22 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS28270 2ad2db1ddfaa8d743a3646d3bd0f2913 280 Gene3D G3DSA:2.60.200.20 196 276 7.5E-24 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS28270 2ad2db1ddfaa8d743a3646d3bd0f2913 280 SMART SM00240 206 255 1.8E-10 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS28270 2ad2db1ddfaa8d743a3646d3bd0f2913 280 Pfam PF00498 FHA domain 208 269 5.0E-15 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS28270 2ad2db1ddfaa8d743a3646d3bd0f2913 280 Pfam PF12401 Protein of unknown function (DUF2662) 5 118 2.3E-41 T 17-03-2017 IPR022128 Protein of unknown function DUF3662 SHXM_RS47870 ddf60477b111a6da9c1b18dab5eee5f1 278 Pfam PF13460 NAD(P)H-binding 7 172 3.9E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47870 ddf60477b111a6da9c1b18dab5eee5f1 278 Gene3D G3DSA:3.40.50.720 1 211 2.6E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47870 ddf60477b111a6da9c1b18dab5eee5f1 278 SUPERFAMILY SSF51735 1 211 4.45E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30450 369be9490f7ab01a77c436826a4f5e3a 92 Pfam PF05768 Glutaredoxin-like domain (DUF836) 17 90 1.8E-18 T 17-03-2017 IPR008554 Glutaredoxin-like SHXM_RS30450 369be9490f7ab01a77c436826a4f5e3a 92 SUPERFAMILY SSF52833 13 91 7.23E-18 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS30450 369be9490f7ab01a77c436826a4f5e3a 92 Gene3D G3DSA:3.40.30.10 17 91 1.5E-25 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 Pfam PF01470 Pyroglutamyl peptidase 3 201 1.3E-71 T 17-03-2017 IPR016125 Peptidase C15, pyroglutamyl peptidase I-like SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 Hamap MF_00417 Pyrrolidone-carboxylate peptidase [pcp]. 2 200 37.414 T 17-03-2017 IPR029762 Pyroglutamyl peptidase I, bacterial-type GO:0005829|GO:0006508|GO:0008234|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 PIRSF PIRSF015592 1 212 1.1E-77 T 17-03-2017 IPR000816 Peptidase C15, pyroglutamyl peptidase I GO:0005829|GO:0006508|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 SUPERFAMILY SSF53182 3 213 2.09E-66 T 17-03-2017 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 ProSitePatterns PS01334 Pyrrolidone-carboxylate peptidase cysteine active site. 130 144 - T 17-03-2017 IPR033694 Pyroglutamyl peptidase I, Cys active site SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 Gene3D G3DSA:3.40.630.20 3 210 5.4E-64 T 17-03-2017 IPR016125 Peptidase C15, pyroglutamyl peptidase I-like SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 TIGRFAM TIGR00504 pyro_pdase: pyroglutamyl-peptidase I 3 211 2.8E-76 T 17-03-2017 IPR029762 Pyroglutamyl peptidase I, bacterial-type GO:0005829|GO:0006508|GO:0008234|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 ProSitePatterns PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 69 85 - T 17-03-2017 IPR033693 Pyroglutamyl peptidase I, Glu active site SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 PRINTS PR00706 Pyroglutamyl peptidase I (C15) family signature 4 27 5.0E-46 T 17-03-2017 IPR000816 Peptidase C15, pyroglutamyl peptidase I GO:0005829|GO:0006508|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 PRINTS PR00706 Pyroglutamyl peptidase I (C15) family signature 62 74 5.0E-46 T 17-03-2017 IPR000816 Peptidase C15, pyroglutamyl peptidase I GO:0005829|GO:0006508|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 PRINTS PR00706 Pyroglutamyl peptidase I (C15) family signature 80 100 5.0E-46 T 17-03-2017 IPR000816 Peptidase C15, pyroglutamyl peptidase I GO:0005829|GO:0006508|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 PRINTS PR00706 Pyroglutamyl peptidase I (C15) family signature 132 148 5.0E-46 T 17-03-2017 IPR000816 Peptidase C15, pyroglutamyl peptidase I GO:0005829|GO:0006508|GO:0016920 SHXM_RS43720 fd6092f972acc5327464d70ed8a86205 214 PRINTS PR00706 Pyroglutamyl peptidase I (C15) family signature 162 174 5.0E-46 T 17-03-2017 IPR000816 Peptidase C15, pyroglutamyl peptidase I GO:0005829|GO:0006508|GO:0016920 SHXM_RS33670 1bd99c42f65d0cb69efed20cb20e2e08 356 Pfam PF02401 LytB protein 12 289 6.7E-89 T 17-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 SHXM_RS33670 1bd99c42f65d0cb69efed20cb20e2e08 356 TIGRFAM TIGR00216 ispH_lytB: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 12 290 3.1E-96 T 17-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 SHXM_RS33670 1bd99c42f65d0cb69efed20cb20e2e08 356 Hamap MF_00191 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [ispH]. 10 293 36.756 T 17-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 Gene3D G3DSA:3.20.20.80 301 593 2.2E-59 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 Gene3D G3DSA:2.60.40.320 179 297 1.8E-13 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 303 593 3.1E-11 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 Gene3D G3DSA:2.60.120.260 11 178 2.8E-56 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 SUPERFAMILY SSF49785 11 187 3.64E-49 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 SUPERFAMILY SSF49303 196 297 6.62E-6 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 23 186 1.3E-15 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 Pfam PF00703 Glycosyl hydrolases family 2 190 297 2.4E-4 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 SUPERFAMILY SSF51445 295 468 4.07E-59 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS01825 a5341082a388c2836e51dd9d4d5ebc43 598 SUPERFAMILY SSF51445 504 592 4.07E-59 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS02290 8b3a38260a611f1adf5488ca5ade0f1a 222 SUPERFAMILY SSF52266 7 220 8.99E-38 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS02290 8b3a38260a611f1adf5488ca5ade0f1a 222 Gene3D G3DSA:3.40.50.1110 10 219 3.5E-36 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS02290 8b3a38260a611f1adf5488ca5ade0f1a 222 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 14 212 1.0E-21 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 Pfam PF00698 Acyl transferase domain 175 444 5.0E-54 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 SUPERFAMILY SSF55048 302 366 1.7E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 SUPERFAMILY SSF52151 367 445 8.63E-60 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 SUPERFAMILY SSF52151 173 303 8.63E-60 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 177 446 2.4E-72 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 Gene3D G3DSA:3.30.70.250 301 365 1.9E-10 T 17-03-2017 SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 Gene3D G3DSA:3.40.366.10 166 297 1.3E-63 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS10770 834ef071144d9d492d4d8da909063733 446 Gene3D G3DSA:3.40.366.10 366 445 1.3E-63 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS18470 b8dc0c9c046be8618f84feb5e6413ac0 441 Pfam PF10009 Uncharacterized protein conserved in bacteria (DUF2252) 30 431 6.6E-120 T 17-03-2017 IPR018721 Protein of unknown function DUF2252 SHXM_RS18470 b8dc0c9c046be8618f84feb5e6413ac0 441 SUPERFAMILY SSF56112 38 149 1.29E-8 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS18470 b8dc0c9c046be8618f84feb5e6413ac0 441 Gene3D G3DSA:3.90.1200.10 75 235 1.4E-7 T 17-03-2017 SHXM_RS25190 a4ce39c01ada9d0a6e2f48590eae39b8 159 SUPERFAMILY SSF69118 12 153 4.71E-42 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS25190 a4ce39c01ada9d0a6e2f48590eae39b8 159 Pfam PF02627 Carboxymuconolactone decarboxylase family 20 101 1.7E-17 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS25190 a4ce39c01ada9d0a6e2f48590eae39b8 159 Gene3D G3DSA:1.20.1290.10 11 156 4.6E-52 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS25190 a4ce39c01ada9d0a6e2f48590eae39b8 159 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 36 84 5.3E-18 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 SMART SM00346 7 93 1.6E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 SUPERFAMILY SSF46785 7 75 2.58E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 Gene3D G3DSA:1.10.10.10 3 73 6.2E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 Pfam PF01614 Bacterial transcriptional regulator 125 230 2.2E-17 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 Gene3D G3DSA:3.30.450.40 74 228 1.1E-40 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 SUPERFAMILY SSF55781 62 234 5.1E-35 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS36350 643200fd45d084bc60f645dc90ef2872 238 Pfam PF09339 IclR helix-turn-helix domain 10 57 1.2E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 92 141 1.1E-11 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 17 66 4.2E-14 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 178 214 5.5E-7 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 SUPERFAMILY SSF81923 4 139 2.55E-26 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 Gene3D G3DSA:1.10.1780.10 1 143 2.8E-41 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 SUPERFAMILY SSF81923 173 220 1.45E-5 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS41095 9d24956a09a9f01b0b0debe11f8c6ea4 323 Gene3D G3DSA:1.10.1780.10 172 227 3.9E-7 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 Pfam PF02065 Melibiase 270 613 4.6E-119 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PIRSF PIRSF005536 5 703 7.6E-190 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 SUPERFAMILY SSF51445 304 633 2.48E-101 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 Pfam PF16874 Glycosyl hydrolase family 36 C-terminal domain 629 700 5.8E-13 T 17-03-2017 IPR031705 Glycosyl hydrolase family 36, C-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 Gene3D G3DSA:3.20.20.70 304 597 4.0E-52 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 Pfam PF16875 Glycosyl hydrolase family 36 N-terminal domain 29 261 3.9E-54 T 17-03-2017 IPR031704 Glycosyl hydrolase family 36, N-terminal KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 309 323 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 445 460 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 337 352 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 387 409 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 497 513 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 273 293 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 221 236 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS13285 fdada880c4275d5b9bfaa2890838cccc 703 PRINTS PR00743 Glycosyl hydrolase family 36 signature 522 538 4.8E-53 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS17460 003996cf72eab4ea6ca9c52778c73380 163 SUPERFAMILY SSF52172 7 155 1.31E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS17460 003996cf72eab4ea6ca9c52778c73380 163 SMART SM00448 8 122 2.8E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17460 003996cf72eab4ea6ca9c52778c73380 163 Pfam PF00072 Response regulator receiver domain 10 122 2.3E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17460 003996cf72eab4ea6ca9c52778c73380 163 Gene3D G3DSA:3.40.50.2300 6 133 8.2E-34 T 17-03-2017 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 ProSitePatterns PS01125 ROK family signature. 247 274 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 Gene3D G3DSA:1.10.10.10 14 83 1.6E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 Gene3D G3DSA:3.30.420.40 253 299 3.5E-21 T 17-03-2017 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 Gene3D G3DSA:3.30.420.40 84 252 5.1E-52 T 17-03-2017 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 SUPERFAMILY SSF46785 14 80 1.28E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 Gene3D G3DSA:3.30.420.40 306 383 1.7E-6 T 17-03-2017 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 SUPERFAMILY SSF53067 88 142 3.15E-35 T 17-03-2017 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 SUPERFAMILY SSF53067 173 384 3.15E-35 T 17-03-2017 SHXM_RS23285 4f377a45f4a16c5b2a178c2231c3670c 390 Pfam PF00480 ROK family 175 296 4.3E-27 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 Gene3D G3DSA:1.10.390.10 327 458 1.0E-20 T 17-03-2017 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 Pfam PF01433 Peptidase family M1 37 352 2.2E-39 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 SUPERFAMILY SSF63737 24 221 6.67E-35 T 17-03-2017 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 311 326 4.8E-15 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 158 173 4.8E-15 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 205 220 4.8E-15 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 330 342 4.8E-15 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS06230 bc27f6580275c1fbfbf7e975c40311a1 462 SUPERFAMILY SSF55486 234 458 2.64E-55 T 17-03-2017 SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 171 190 3.8E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 159 3.8E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 97 108 3.8E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 26 258 4.6E-62 T 17-03-2017 SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 SUPERFAMILY SSF51735 17 259 2.32E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 158 186 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 Gene3D G3DSA:3.40.50.720 16 258 2.1E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 192 209 1.6E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 190 1.6E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 21 38 1.6E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 161 1.6E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 226 246 1.6E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47110 69d95e68d09960e99ba7ff4f6d88932c 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 97 108 1.6E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37940 82a6780294a6a87ad7497ee2548a8730 533 Pfam PF12623 RNA repair, ligase-Pnkp-associating, region of Hen1 1 248 1.2E-116 T 17-03-2017 IPR024740 Hen1, N-terminal SHXM_RS37940 82a6780294a6a87ad7497ee2548a8730 533 Pfam PF13489 Methyltransferase domain 315 477 7.2E-11 T 17-03-2017 SHXM_RS37940 82a6780294a6a87ad7497ee2548a8730 533 TIGRFAM TIGR04074 bacter_Hen1: 3' terminal RNA ribose 2'-O-methyltransferase Hen1 3 507 3.7E-199 T 17-03-2017 IPR024026 3'-RNA ribose 2'-O-methyltransferase, Hen1, bacterial SHXM_RS37940 82a6780294a6a87ad7497ee2548a8730 533 Gene3D G3DSA:3.40.50.150 304 477 5.3E-21 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS37940 82a6780294a6a87ad7497ee2548a8730 533 SUPERFAMILY SSF53335 297 477 1.27E-20 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11460 bc837fab36b98c8423113a55281124ee 424 Pfam PF01425 Amidase 12 407 5.3E-66 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS11460 bc837fab36b98c8423113a55281124ee 424 SUPERFAMILY SSF75304 3 415 4.97E-94 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS11460 bc837fab36b98c8423113a55281124ee 424 Gene3D G3DSA:3.90.1300.10 3 418 5.6E-99 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS02070 16a926b59d91c33407ce21be89668168 256 SUPERFAMILY SSF102215 5 248 4.71E-52 T 17-03-2017 IPR024087 Creatininase-like domain KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS02070 16a926b59d91c33407ce21be89668168 256 Gene3D G3DSA:3.40.50.10310 4 249 2.2E-68 T 17-03-2017 IPR024087 Creatininase-like domain KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS02070 16a926b59d91c33407ce21be89668168 256 Pfam PF02633 Creatinine amidohydrolase 8 245 2.5E-54 T 17-03-2017 IPR003785 Creatininase/formamide hydrolase KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 TIGRFAM TIGR00260 thrC: threonine synthase 14 336 5.7E-94 T 17-03-2017 IPR004450 Threonine synthase-like SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 Gene3D G3DSA:3.40.50.1100 151 337 2.3E-46 T 17-03-2017 SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 Gene3D G3DSA:3.40.50.1100 66 150 2.9E-42 T 17-03-2017 SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 SUPERFAMILY SSF53686 8 343 2.1E-101 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 31 329 1.7E-72 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 PIRSF PIRSF038945 2 361 4.7E-163 T 17-03-2017 IPR026260 Threonine synthase, bacterial/archaeal GO:0004795|GO:0009088 KEGG: 00260+4.2.3.1|KEGG: 00750+4.2.3.1 SHXM_RS35170 2ebbe8b7552db76c9ae272b0458e57fc 362 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 58 71 - T 17-03-2017 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 SHXM_RS41845 3ee4da218ad03e01631c13a2409664cb 307 Gene3D G3DSA:3.40.50.1820 51 304 2.4E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41845 3ee4da218ad03e01631c13a2409664cb 307 SUPERFAMILY SSF53474 31 304 5.17E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41845 3ee4da218ad03e01631c13a2409664cb 307 Pfam PF07859 alpha/beta hydrolase fold 79 280 4.4E-52 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS49680 fec3f34452ed76332fbae56130be0693 434 Gene3D G3DSA:3.40.190.10 43 175 3.1E-13 T 17-03-2017 SHXM_RS49680 fec3f34452ed76332fbae56130be0693 434 Pfam PF13416 Bacterial extracellular solute-binding protein 63 362 1.7E-33 T 17-03-2017 SHXM_RS49680 fec3f34452ed76332fbae56130be0693 434 Gene3D G3DSA:3.40.190.10 176 362 7.6E-39 T 17-03-2017 SHXM_RS49680 fec3f34452ed76332fbae56130be0693 434 SUPERFAMILY SSF53850 35 433 1.14E-60 T 17-03-2017 SHXM_RS04925 fdcef7326f265702910bae667fdb2f73 128 Gene3D G3DSA:3.30.429.10 3 126 2.2E-36 T 17-03-2017 SHXM_RS04925 fdcef7326f265702910bae667fdb2f73 128 Pfam PF14552 Tautomerase enzyme 37 119 1.4E-26 T 17-03-2017 IPR004370 4-oxalocrotonate tautomerase GO:0006725|GO:0016853 SHXM_RS04925 fdcef7326f265702910bae667fdb2f73 128 SUPERFAMILY SSF55331 2 126 4.42E-33 T 17-03-2017 IPR014347 Tautomerase/MIF superfamily SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 181 187 - T 17-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 Gene3D G3DSA:3.40.50.150 85 278 1.3E-55 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 TIGRFAM TIGR00536 hemK_fam: methyltransferase, HemK family 55 278 1.0E-47 T 17-03-2017 IPR004556 Modification methylase HemK GO:0006479|GO:0008276 SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 Pfam PF05175 Methyltransferase small domain 114 187 7.9E-13 T 17-03-2017 IPR007848 Methyltransferase small domain GO:0008168 SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 Hamap MF_02126 Release factor glutamine methyltransferase [prmC]. 4 278 41.795 T 17-03-2017 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 SUPERFAMILY SSF53335 21 251 2.5E-47 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 TIGRFAM TIGR03534 RF_mod_PrmC: protein-(glutamine-N5) methyltransferase, release factor-specific 26 274 2.4E-70 T 17-03-2017 IPR019874 Protein-(glutamine-N5) methyltransferase, release factor-specific GO:0008168 SHXM_RS35200 3a79b875de0c14a81178a73a934c367b 281 Gene3D G3DSA:1.10.8.10 8 83 9.8E-17 T 17-03-2017 SHXM_RS14450 2f2afed874cc915ac69b067fc3c7fdd4 435 Gene3D G3DSA:3.40.50.2300 101 222 1.8E-21 T 17-03-2017 SHXM_RS14450 2f2afed874cc915ac69b067fc3c7fdd4 435 Gene3D G3DSA:3.40.50.2300 223 395 2.7E-33 T 17-03-2017 SHXM_RS14450 2f2afed874cc915ac69b067fc3c7fdd4 435 SUPERFAMILY SSF53822 114 397 1.15E-53 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS14450 2f2afed874cc915ac69b067fc3c7fdd4 435 Pfam PF13407 Periplasmic binding protein domain 103 359 6.3E-58 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 SMART SM00448 7 120 4.1E-35 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 Gene3D G3DSA:1.10.10.10 156 212 1.2E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 SUPERFAMILY SSF46894 150 212 2.89E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 Pfam PF00072 Response regulator receiver domain 9 120 1.4E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 183 1.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 153 167 1.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 183 195 1.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 Gene3D G3DSA:3.40.50.2300 6 155 1.6E-43 T 17-03-2017 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 Pfam PF00196 Bacterial regulatory proteins, luxR family 152 207 7.3E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 SMART SM00421 150 207 2.0E-28 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 ProSitePatterns PS00622 LuxR-type HTH domain signature. 167 194 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17250 0d4561be615c66bd57a010d2ca8bd296 214 SUPERFAMILY SSF52172 6 134 5.12E-37 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS19580 cad026d9e7ebc706a83cc9cc88321b7b 206 Gene3D G3DSA:1.10.357.10 68 196 2.4E-20 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS19580 cad026d9e7ebc706a83cc9cc88321b7b 206 SUPERFAMILY SSF48498 87 195 6.3E-14 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19580 cad026d9e7ebc706a83cc9cc88321b7b 206 Pfam PF16859 Bacterial transcriptional repressor C-terminal 84 195 6.1E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS19580 cad026d9e7ebc706a83cc9cc88321b7b 206 Gene3D G3DSA:1.10.10.60 11 67 1.7E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19580 cad026d9e7ebc706a83cc9cc88321b7b 206 SUPERFAMILY SSF46689 14 76 5.2E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19580 cad026d9e7ebc706a83cc9cc88321b7b 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 30 71 1.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 SUPERFAMILY SSF52317 226 271 3.61E-37 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 SUPERFAMILY SSF52317 306 458 3.61E-37 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 18 258 3.1E-23 T 17-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 Hamap MF_00028 Cobyric acid synthase [cobQ]. 1 522 162.122 T 17-03-2017 IPR004459 Cobyric acid synthase CobQ GO:0003824|GO:0009236 SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 SUPERFAMILY SSF52540 17 109 1.01E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 SUPERFAMILY SSF52540 145 273 1.01E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 Gene3D G3DSA:3.40.50.300 17 109 4.5E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 Gene3D G3DSA:3.40.50.300 145 269 4.5E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 Gene3D G3DSA:3.40.50.880 294 478 2.0E-39 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17520 05ccb9f6fa21bf076204a8e8f425bbef 539 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 294 465 1.7E-44 T 17-03-2017 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 SHXM_RS21625 8a905fd347f3796cfb40abb35a245b24 545 SMART SM01118 5 214 1.6E-15 T 17-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 SHXM_RS21625 8a905fd347f3796cfb40abb35a245b24 545 SUPERFAMILY SSF55154 6 213 3.71E-37 T 17-03-2017 IPR033469 CYTH-like domain Reactome: R-HSA-196819 SHXM_RS21625 8a905fd347f3796cfb40abb35a245b24 545 Pfam PF01928 CYTH domain 40 178 1.5E-11 T 17-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 SHXM_RS21625 8a905fd347f3796cfb40abb35a245b24 545 SMART SM00880 261 527 1.8E-61 T 17-03-2017 IPR007899 CHAD domain SHXM_RS21625 8a905fd347f3796cfb40abb35a245b24 545 Gene3D G3DSA:2.40.320.10 6 215 3.1E-48 T 17-03-2017 IPR023577 CYTH domain Reactome: R-HSA-196819 SHXM_RS21625 8a905fd347f3796cfb40abb35a245b24 545 Pfam PF05235 CHAD domain 261 493 2.0E-50 T 17-03-2017 IPR007899 CHAD domain SHXM_RS23020 e2450e8f2eed01892fb64dcc83715178 284 SUPERFAMILY SSF53474 4 277 1.5E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23020 e2450e8f2eed01892fb64dcc83715178 284 Gene3D G3DSA:3.40.50.1820 2 277 2.8E-36 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23020 e2450e8f2eed01892fb64dcc83715178 284 Pfam PF12697 Alpha/beta hydrolase family 26 271 3.8E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS02060 92a5fc335eee22b22a3751e34d03ee3c 290 Pfam PF00005 ABC transporter 36 192 1.6E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS02060 92a5fc335eee22b22a3751e34d03ee3c 290 ProSitePatterns PS00211 ABC transporters family signature. 164 178 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS02060 92a5fc335eee22b22a3751e34d03ee3c 290 SUPERFAMILY SSF52540 16 263 4.66E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02060 92a5fc335eee22b22a3751e34d03ee3c 290 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 243 275 8.7E-8 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS02060 92a5fc335eee22b22a3751e34d03ee3c 290 SMART SM00382 44 241 1.8E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02060 92a5fc335eee22b22a3751e34d03ee3c 290 Gene3D G3DSA:3.40.50.300 8 272 1.3E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 Gene3D G3DSA:3.40.50.1820 13 269 2.3E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 PRINTS PR00111 Alpha/beta hydrolase fold signature 115 128 3.8E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 PRINTS PR00111 Alpha/beta hydrolase fold signature 57 72 3.8E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 PRINTS PR00111 Alpha/beta hydrolase fold signature 101 114 3.8E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 PRINTS PR00111 Alpha/beta hydrolase fold signature 213 227 3.8E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 Pfam PF00561 alpha/beta hydrolase fold 32 137 1.8E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS05510 1aa8d8ea0d9e0980b42150c957edcf84 274 SUPERFAMILY SSF53474 16 268 1.49E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 Gene3D G3DSA:3.30.300.20 212 318 3.1E-36 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 Gene3D G3DSA:3.40.50.300 25 211 6.7E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 TIGRFAM TIGR00231 small_GTP: small GTP-binding protein domain 27 150 1.2E-15 T 17-03-2017 IPR005225 Small GTP-binding protein domain GO:0005525 SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 Pfam PF01926 50S ribosome-binding GTPase 26 139 6.8E-20 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 TIGRFAM TIGR00436 era: GTP-binding protein Era 23 304 1.7E-64 T 17-03-2017 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 Hamap MF_00367 GTPase Era [era]. 20 321 34.251 T 17-03-2017 IPR005662 GTP-binding protein Era GO:0003723|GO:0005525|GO:0005622 SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 SUPERFAMILY SSF52540 26 233 1.22E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 Pfam PF07650 KH domain 228 310 5.3E-16 T 17-03-2017 IPR004044 K Homology domain, type 2 GO:0003723 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS21230 3546b3db5173d695d303b4c6ee564f67 321 SUPERFAMILY SSF54814 202 321 1.44E-34 T 17-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 SHXM_RS21555 0746ac52bec9dceeaa7c5356395667b8 203 SUPERFAMILY SSF52374 10 201 6.57E-52 T 17-03-2017 SHXM_RS21555 0746ac52bec9dceeaa7c5356395667b8 203 Gene3D G3DSA:3.40.50.620 10 201 7.1E-65 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS21555 0746ac52bec9dceeaa7c5356395667b8 203 TIGRFAM TIGR00125 cyt_tran_rel: cytidyltransferase-like domain 13 76 6.4E-11 T 17-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SHXM_RS21555 0746ac52bec9dceeaa7c5356395667b8 203 Hamap MF_00244 Probable nicotinate-nucleotide adenylyltransferase [nadD]. 10 200 30.232 T 17-03-2017 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: R-HSA-196807 SHXM_RS21555 0746ac52bec9dceeaa7c5356395667b8 203 TIGRFAM TIGR00482 TIGR00482: nicotinate (nicotinamide) nucleotide adenylyltransferase 14 199 5.6E-53 T 17-03-2017 IPR005248 Probable nicotinate-nucleotide adenylyltransferase GO:0009435|GO:0016779 KEGG: 00760+2.7.7.18|MetaCyc: PWY-5381|MetaCyc: PWY-5653|Reactome: R-HSA-196807 SHXM_RS21555 0746ac52bec9dceeaa7c5356395667b8 203 Pfam PF01467 Cytidylyltransferase-like 14 174 2.3E-29 T 17-03-2017 IPR004821 Cytidyltransferase-like domain GO:0003824|GO:0009058 SHXM_RS44830 06c39e5d0c79463d6cc77397d694dd83 136 Gene3D G3DSA:3.30.530.20 3 135 3.7E-35 T 17-03-2017 IPR023393 START-like domain SHXM_RS44830 06c39e5d0c79463d6cc77397d694dd83 136 SUPERFAMILY SSF55961 3 135 9.78E-35 T 17-03-2017 SHXM_RS44830 06c39e5d0c79463d6cc77397d694dd83 136 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 13 133 5.1E-26 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS26810 28a735eb7a8540f0c58e332b121e4ff2 237 SUPERFAMILY SSF53335 14 182 9.85E-12 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26810 28a735eb7a8540f0c58e332b121e4ff2 237 Gene3D G3DSA:3.40.50.150 16 127 4.9E-8 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16185 ea5064b6ae97ccd86fe337bfe1a75f78 279 Pfam PF13560 Helix-turn-helix domain 5 84 1.3E-16 T 17-03-2017 SHXM_RS16185 ea5064b6ae97ccd86fe337bfe1a75f78 279 SUPERFAMILY SSF47413 29 78 7.41E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS16185 ea5064b6ae97ccd86fe337bfe1a75f78 279 SMART SM00530 9 81 1.4E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS16185 ea5064b6ae97ccd86fe337bfe1a75f78 279 Gene3D G3DSA:1.10.260.40 3 80 1.7E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49830 6a13c35933d476cb942aa6f9f86a518d 122 SUPERFAMILY SSF52540 2 71 2.77E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49830 6a13c35933d476cb942aa6f9f86a518d 122 Gene3D G3DSA:3.40.50.300 2 64 6.0E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 Gene3D G3DSA:3.40.50.300 16 261 4.4E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 SMART SM00382 45 237 1.3E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 Pfam PF00005 ABC transporter 37 188 1.5E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 237 328 6.4E-25 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 239 306 4.0E-17 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS32965 ac47ebda803873399e3d3d3abdf28e87 342 SUPERFAMILY SSF52540 16 259 1.11E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 TIGRFAM TIGR01127 ilvA_1Cterm: threonine ammonia-lyase 23 400 1.4E-134 T 17-03-2017 IPR005789 Threonine dehydratase, catabolic GO:0004794|GO:0006567 KEGG: 00260+4.3.1.19|KEGG: 00290+4.3.1.19 SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 Gene3D G3DSA:3.40.50.1100 72 320 7.5E-79 T 17-03-2017 SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 Gene3D G3DSA:3.30.70.260 329 394 4.3E-5 T 17-03-2017 SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 ProSitePatterns PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 44 57 - T 17-03-2017 IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site GO:0006520|GO:0030170 SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 SUPERFAMILY SSF55021 327 394 9.51E-6 T 17-03-2017 SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 21 304 3.2E-82 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS33195 2bf3670b7dd1767702cb0b1720612833 401 SUPERFAMILY SSF53686 5 313 1.83E-94 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 SUPERFAMILY SSF54713 150 277 8.24E-38 T 17-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Pfam PF00889 Elongation factor TS 73 277 7.2E-62 T 17-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 SUPERFAMILY SSF54713 57 147 1.83E-18 T 17-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Gene3D G3DSA:3.30.479.20 152 193 3.9E-24 T 17-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Gene3D G3DSA:3.30.479.20 242 277 3.9E-24 T 17-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 TIGRFAM TIGR00116 tsf: translation elongation factor Ts 1 277 3.0E-70 T 17-03-2017 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 ProSitePatterns PS01126 Elongation factor Ts signature 1. 12 27 - T 17-03-2017 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Hamap MF_00050 Elongation factor Ts [tsf]. 1 278 63.639 T 17-03-2017 IPR001816 Translation elongation factor EFTs/EF1B GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Gene3D G3DSA:1.10.8.10 3 55 2.4E-24 T 17-03-2017 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Gene3D G3DSA:1.10.286.20 198 241 6.6E-17 T 17-03-2017 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 SUPERFAMILY SSF46934 3 55 1.08E-15 T 17-03-2017 IPR009060 UBA-like GO:0005515 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 ProSitePatterns PS01127 Elongation factor Ts signature 2. 77 87 - T 17-03-2017 IPR018101 Translation elongation factor Ts, conserved site GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS36660 8996e1c1d06941364f1bfe27aa312b82 278 Gene3D G3DSA:3.30.479.20 57 150 3.8E-20 T 17-03-2017 IPR014039 Translation elongation factor EFTs/EF1B, dimerisation GO:0003746|GO:0005622|GO:0006414 Reactome: R-HSA-5389840 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF51735 3079 3296 1.75E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.50.1820 3435 3698 1.4E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF51735 1105 1337 5.75E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.366.10 550 670 1.2E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.366.10 741 832 1.2E-72 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF52151 743 829 5.49E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF52151 550 676 5.49E-66 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 1619 1635 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF53901 1461 1828 1.06E-97 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00975 Thioesterase domain 3498 3591 5.7E-15 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.30.70.250 2124 2157 4.3E-5 T 17-03-2017 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF51735 905 1092 2.84E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 2790 2845 7.0E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF53901 36 393 1.69E-97 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3081 3261 4.4E-59 T 17-03-2017 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1105 1284 5.5E-53 T 17-03-2017 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 405 516 5.4E-18 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 1835 1919 6.1E-10 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF14765 Polyketide synthase dehydratase 2327 2586 6.0E-51 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00824 Thioesterase 3489 3694 3.2E-64 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:1.10.1200.10 3345 3420 1.0E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:1.10.1200.10 1370 1441 1.4E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 192 208 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.90.180.10 2772 2904 7.6E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1715 1829 1.2E-43 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 287 402 9.0E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF08659 KR domain 1105 1282 2.2E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF08659 KR domain 3081 3259 5.6E-57 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.50.720 2905 2998 1.9E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.47.10 40 291 1.6E-86 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.47.10 1465 1718 4.9E-88 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 2898 2919 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00825 Beta-ketoacyl synthase 1465 1882 7.8E-198 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00825 Beta-ketoacyl synthase 40 455 2.3E-197 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF55048 2121 2155 2.22E-5 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.30.70.250 675 735 5.6E-7 T 17-03-2017 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF51735 2869 3005 9.47E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00823 Phosphopantetheine attachment site 3347 3419 6.0E-26 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00823 Phosphopantetheine attachment site 1369 1441 1.3E-29 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF50129 2768 2903 1.57E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF53474 3464 3695 6.68E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF53474 3378 3415 6.68E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00550 Phosphopantetheine attachment site 3350 3415 2.7E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00550 Phosphopantetheine attachment site 1372 1437 5.6E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF52151 1981 2106 1.07E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF52151 2161 2260 1.07E-65 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.366.10 1975 2101 1.0E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.366.10 2160 2281 1.0E-70 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 554 843 3.0E-107 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 1984 2269 2.2E-94 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.47.10 292 454 1.0E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.47.10 1719 1879 4.1E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 ProSitePatterns PS00012 Phosphopantetheine attachment site. 3374 3389 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00698 Acyl transferase domain 1982 2288 6.7E-78 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00698 Acyl transferase domain 552 831 6.6E-79 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 38 279 1.5E-79 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1463 1706 5.0E-82 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF47336 1367 1478 7.46E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00829 2772 3071 5.3E-161 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF47336 3341 3431 1.07E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF51735 2593 2753 3.35E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM01294 1370 1437 2.7E-6 T 17-03-2017 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM01294 3348 3415 5.6E-5 T 17-03-2017 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.50.720 1105 1317 1.1E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Gene3D G3DSA:3.40.50.720 3080 3265 1.2E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SMART SM00826 2327 2483 6.6E-70 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 SUPERFAMILY SSF55048 675 739 2.09E-11 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS46810 aa768c6a27331c5e3844407794ffc363 3702 Pfam PF00107 Zinc-binding dehydrogenase 2909 3002 3.3E-17 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 Gene3D G3DSA:1.25.40.10 566 709 6.3E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 Pfam PF00069 Protein kinase domain 213 420 2.0E-25 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 SMART SM00220 213 462 2.6E-12 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 Gene3D G3DSA:1.10.510.10 339 421 3.4E-15 T 17-03-2017 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 Gene3D G3DSA:3.30.200.20 208 338 4.4E-18 T 17-03-2017 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 Pfam PF16918 Protein kinase G tetratricopeptide repeat 480 773 2.1E-52 T 17-03-2017 IPR031636 Protein kinase G, tetratricopeptide repeat containing domain KEGG: 04150+2.7.11.1|KEGG: 04151+2.7.11.1 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 SUPERFAMILY SSF48452 573 694 6.7E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 SUPERFAMILY SSF56112 204 468 1.31E-38 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS31955 3e22cc491b169a6c1a91cf1743116fe4 861 Pfam PF16919 Protein kinase G rubredoxin domain 108 212 2.1E-10 T 17-03-2017 IPR031634 Protein kinase G, rubredoxin domain KEGG: 04150+2.7.11.1|KEGG: 04151+2.7.11.1 SHXM_RS36530 a73c93783fa30389fefb793928ddbc60 504 Gene3D G3DSA:1.25.40.10 250 456 1.4E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36530 a73c93783fa30389fefb793928ddbc60 504 SUPERFAMILY SSF48452 240 356 2.3E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36530 a73c93783fa30389fefb793928ddbc60 504 SUPERFAMILY SSF48452 419 452 2.3E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12150 afd152f354b1d8bf1856c79706920621 161 SUPERFAMILY SSF52121 11 155 4.32E-55 T 17-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12150 afd152f354b1d8bf1856c79706920621 161 Hamap MF_00178 6,7-dimethyl-8-ribityllumazine synthase [ribH]. 12 156 28.723 T 17-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12150 afd152f354b1d8bf1856c79706920621 161 Pfam PF00885 6,7-dimethyl-8-ribityllumazine synthase 17 152 8.4E-52 T 17-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12150 afd152f354b1d8bf1856c79706920621 161 Gene3D G3DSA:3.40.50.960 13 156 4.9E-58 T 17-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12150 afd152f354b1d8bf1856c79706920621 161 TIGRFAM TIGR00114 lumazine-synth: 6,7-dimethyl-8-ribityllumazine synthase 17 151 4.0E-43 T 17-03-2017 IPR002180 6,7-dimethyl-8-ribityllumazine synthase GO:0009231|GO:0009349 KEGG: 00740+2.5.1.78|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 Gene3D G3DSA:3.40.50.1820 3 239 1.1E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00412 Epoxide hydrolase signature 8 26 1.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00412 Epoxide hydrolase signature 87 100 1.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00412 Epoxide hydrolase signature 28 43 1.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00412 Epoxide hydrolase signature 73 86 1.2E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 Pfam PF12697 Alpha/beta hydrolase family 5 231 1.8E-16 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 SUPERFAMILY SSF53474 5 238 2.1E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00111 Alpha/beta hydrolase fold signature 87 100 3.4E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00111 Alpha/beta hydrolase fold signature 73 86 3.4E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13220 fead7490800749d3b7e636b1c8c454a3 241 PRINTS PR00111 Alpha/beta hydrolase fold signature 28 43 3.4E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 PIRSF PIRSF002131 4 134 4.0E-54 T 17-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 Pfam PF00411 Ribosomal protein S11 24 133 1.3E-48 T 17-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 Hamap MF_01310 30S ribosomal protein S11 [rpsK]. 4 134 34.428 T 17-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 TIGRFAM TIGR03632 uS11_bact: ribosomal protein uS11 15 131 1.7E-59 T 17-03-2017 IPR019981 Ribosomal protein S11, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 SUPERFAMILY SSF53137 19 134 4.8E-50 T 17-03-2017 SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 ProSitePatterns PS00054 Ribosomal protein S11 signature. 102 124 - T 17-03-2017 IPR018102 Ribosomal S11, conserved site SHXM_RS31300 5bdb6e843d159f125f4fceb9cac921fa 134 Gene3D G3DSA:3.30.420.80 11 134 2.3E-58 T 17-03-2017 IPR001971 Ribosomal protein S11 GO:0003735|GO:0005840|GO:0006412 SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 SMART SM00895 92 214 4.4E-22 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 Gene3D G3DSA:1.10.10.10 4 71 1.1E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 SMART SM00345 7 66 5.7E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 Pfam PF00392 Bacterial regulatory proteins, gntR family 5 66 2.1E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 SUPERFAMILY SSF46785 4 70 1.28E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 SUPERFAMILY SSF48008 89 221 1.18E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 40 56 5.2E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 26 40 5.2E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 Gene3D G3DSA:1.20.120.530 88 221 3.4E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS16010 8a1b7e9325ae77490bf4ec421bf2d124 223 Pfam PF07729 FCD domain 92 213 6.9E-27 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS40480 8617a18bd872ecd818ccbcd2f8903a9f 428 SUPERFAMILY SSF52317 4 194 5.18E-37 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS40480 8617a18bd872ecd818ccbcd2f8903a9f 428 Gene3D G3DSA:3.40.50.150 243 420 2.4E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40480 8617a18bd872ecd818ccbcd2f8903a9f 428 Gene3D G3DSA:3.40.50.880 3 198 3.0E-49 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS40480 8617a18bd872ecd818ccbcd2f8903a9f 428 Pfam PF08241 Methyltransferase domain 274 370 5.7E-18 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS40480 8617a18bd872ecd818ccbcd2f8903a9f 428 SUPERFAMILY SSF53335 239 420 3.56E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40480 8617a18bd872ecd818ccbcd2f8903a9f 428 Pfam PF00117 Glutamine amidotransferase class-I 45 181 5.1E-16 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS14420 fda51cd5fc5fbe5b3897f868bfb339f3 388 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 60 375 1.0E-46 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS14420 fda51cd5fc5fbe5b3897f868bfb339f3 388 Pfam PF04261 Dyp-type peroxidase family 60 375 8.7E-47 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS14420 fda51cd5fc5fbe5b3897f868bfb339f3 388 SUPERFAMILY SSF54909 57 376 8.22E-51 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS34690 9520c58f24549a765e5868294bd315e0 130 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 10 108 5.1E-17 T 17-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 SHXM_RS34690 9520c58f24549a765e5868294bd315e0 130 SUPERFAMILY SSF52091 10 115 2.75E-20 T 17-03-2017 IPR002645 STAS domain SHXM_RS34690 9520c58f24549a765e5868294bd315e0 130 Gene3D G3DSA:3.30.750.24 10 115 7.0E-24 T 17-03-2017 IPR002645 STAS domain SHXM_RS34690 9520c58f24549a765e5868294bd315e0 130 Pfam PF13466 STAS domain 23 101 7.1E-13 T 17-03-2017 IPR002645 STAS domain SHXM_RS33460 fe8ba1241d2b49572b9b1d21b419c3f5 157 Pfam PF07811 TadE-like protein 29 71 9.4E-8 T 17-03-2017 IPR012495 TadE-like SHXM_RS02805 46a7c264d8047b9124b674212c2155e8 141 ProSitePatterns PS01117 MarR-type HTH domain signature. 59 93 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS02805 46a7c264d8047b9124b674212c2155e8 141 Gene3D G3DSA:1.10.10.10 27 98 1.7E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02805 46a7c264d8047b9124b674212c2155e8 141 SUPERFAMILY SSF46785 17 136 1.07E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02805 46a7c264d8047b9124b674212c2155e8 141 SMART SM00347 24 121 9.5E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02805 46a7c264d8047b9124b674212c2155e8 141 Gene3D G3DSA:1.10.287.100 99 136 1.4E-15 T 17-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 SHXM_RS02805 46a7c264d8047b9124b674212c2155e8 141 Pfam PF12802 MarR family 27 83 6.1E-12 T 17-03-2017 SHXM_RS01490 d427b1b5da844b944fe85ef4d024bfdf 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 129 306 9.3E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01490 d427b1b5da844b944fe85ef4d024bfdf 313 Gene3D G3DSA:1.10.3720.10 31 300 6.7E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01490 d427b1b5da844b944fe85ef4d024bfdf 313 SUPERFAMILY SSF161098 29 313 5.76E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 Gene3D G3DSA:3.40.190.10 180 273 1.1E-20 T 17-03-2017 SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 Gene3D G3DSA:3.40.190.10 91 179 4.4E-13 T 17-03-2017 SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 Pfam PF03466 LysR substrate binding domain 88 293 8.1E-36 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 SUPERFAMILY SSF46785 1 111 1.68E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 4.7E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 SUPERFAMILY SSF53850 88 300 8.28E-31 T 17-03-2017 SHXM_RS22475 7e4ba21f22160e755d1e5bbe4c3c8295 304 Gene3D G3DSA:1.10.10.10 1 87 7.5E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Hamap MF_01897 DNA gyrase subunit A [gyrA]. 20 835 23.139 T 17-03-2017 IPR005743 DNA gyrase, subunit A GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Gene3D G3DSA:3.30.1360.40 258 354 7.9E-34 T 17-03-2017 IPR024946 Arginine repressor C-terminal-like domain SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 684 732 2.4E-10 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 632 681 2.0E-7 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 525 570 7.6E-14 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 738 783 5.4E-13 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 787 831 2.9E-11 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 576 622 3.7E-8 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Gene3D G3DSA:3.90.199.10 355 419 2.5E-114 T 17-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Gene3D G3DSA:3.90.199.10 48 257 2.5E-114 T 17-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 SUPERFAMILY SSF56719 48 508 1.7E-172 T 17-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 TIGRFAM TIGR01063 gyrA: DNA gyrase, A subunit 26 833 0.0 T 17-03-2017 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Gene3D G3DSA:2.120.10.90 518 832 5.7E-117 T 17-03-2017 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 SMART SM00434 29 486 3.2E-281 T 17-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 SUPERFAMILY SSF101904 520 842 6.02E-97 T 17-03-2017 SHXM_RS28155 8ecd906ebc27c3fd2047466471b79936 874 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 50 493 8.0E-151 T 17-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS14855 2c482a98ee7614aa937e96f3d699668b 333 Pfam PF00296 Luciferase-like monooxygenase 6 306 1.3E-55 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14855 2c482a98ee7614aa937e96f3d699668b 333 TIGRFAM TIGR03842 F420_CPS_4043: F420-dependent oxidoreductase, CPS_4043 family 2 331 1.3E-178 T 17-03-2017 IPR022315 F420-dependent oxidoreductase-predicted, CPS4043 SHXM_RS14855 2c482a98ee7614aa937e96f3d699668b 333 Gene3D G3DSA:3.20.20.30 1 331 1.1E-71 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14855 2c482a98ee7614aa937e96f3d699668b 333 SUPERFAMILY SSF51679 1 329 3.14E-60 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 ProSitePatterns PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 110 125 - T 17-03-2017 IPR017872 Pyrimidine-nucleoside phosphorylase, conserved site GO:0006206 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 SUPERFAMILY SSF47648 1 69 1.2E-20 T 17-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 Pfam PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain 335 407 3.3E-23 T 17-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 SMART SM00941 334 408 3.2E-34 T 17-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 Gene3D G3DSA:1.20.970.10 1 67 2.0E-28 T 17-03-2017 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 Gene3D G3DSA:3.40.1030.10 70 316 1.7E-110 T 17-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 Pfam PF00591 Glycosyl transferase family, a/b domain 78 284 8.3E-35 T 17-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 Gene3D G3DSA:3.90.1170.30 318 411 5.1E-31 T 17-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 Pfam PF02885 Glycosyl transferase family, helical bundle domain 6 66 9.2E-19 T 17-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 TIGRFAM TIGR02644 Y_phosphoryl: pyrimidine-nucleoside phosphorylase 4 405 1.1E-168 T 17-03-2017 IPR018090 Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic GO:0006213|GO:0016154 KEGG: 00240+2.4.2.4|KEGG: 00983+2.4.2.4|MetaCyc: PWY-7181|Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 SUPERFAMILY SSF52418 69 316 1.07E-82 T 17-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 PIRSF PIRSF000478 1 424 4.4E-152 T 17-03-2017 IPR000053 Thymidine/pyrimidine-nucleoside phosphorylase GO:0004645|GO:0006206 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS24840 a935bb0cac9bbd43b2dae6f5b2fb06f7 425 SUPERFAMILY SSF54680 321 424 1.83E-25 T 17-03-2017 IPR013102 Pyrimidine nucleoside phosphorylase, C-terminal GO:0006213|GO:0016763 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 ProSitePatterns PS00221 MIP family signature. 58 66 - T 17-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 SUPERFAMILY SSF81338 4 223 1.09E-55 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 TIGRFAM TIGR00861 MIP: MIP family channel proteins 8 219 4.5E-51 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 Pfam PF00230 Major intrinsic protein 3 219 1.3E-48 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 PRINTS PR00783 Major intrinsic protein family signature 77 96 5.0E-52 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 PRINTS PR00783 Major intrinsic protein family signature 4 23 5.0E-52 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 PRINTS PR00783 Major intrinsic protein family signature 202 222 5.0E-52 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 PRINTS PR00783 Major intrinsic protein family signature 40 64 5.0E-52 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 PRINTS PR00783 Major intrinsic protein family signature 133 151 5.0E-52 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 PRINTS PR00783 Major intrinsic protein family signature 163 185 5.0E-52 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS13155 0ed544789759c6f49eaa26bd168eec78 266 Gene3D G3DSA:1.20.1080.10 3 222 3.3E-60 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS49490 91a89b20482301bd49d10ef45ef37ce1 173 Pfam PF05861 Bacterial phosphonate metabolism protein (PhnI) 1 160 2.8E-39 T 17-03-2017 IPR008773 Phosphonate metabolism protein PhnI GO:0019634 SHXM_RS13230 5df85a06abd70e906bd1697081b48108 419 Gene3D G3DSA:3.60.15.10 83 365 1.4E-104 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS13230 5df85a06abd70e906bd1697081b48108 419 Pfam PF12706 Beta-lactamase superfamily domain 114 315 2.2E-53 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS13230 5df85a06abd70e906bd1697081b48108 419 SUPERFAMILY SSF56281 201 352 1.44E-35 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS13230 5df85a06abd70e906bd1697081b48108 419 SUPERFAMILY SSF56281 97 174 1.44E-35 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS27480 58c2602f7a8e9e6cb6c5b517c2db9643 60 SUPERFAMILY SSF55729 1 48 7.77E-12 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS27480 58c2602f7a8e9e6cb6c5b517c2db9643 60 Gene3D G3DSA:3.40.630.30 1 48 1.4E-14 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS22600 a65f6b67ae63f6a752182c5fb2e04e35 550 SUPERFAMILY SSF52096 29 272 1.12E-71 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS22600 a65f6b67ae63f6a752182c5fb2e04e35 550 Pfam PF01039 Carboxyl transferase domain 51 530 1.7E-150 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS22600 a65f6b67ae63f6a752182c5fb2e04e35 550 SUPERFAMILY SSF52096 285 533 4.46E-88 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS22600 a65f6b67ae63f6a752182c5fb2e04e35 550 Gene3D G3DSA:3.90.226.10 286 533 2.5E-95 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS22600 a65f6b67ae63f6a752182c5fb2e04e35 550 Gene3D G3DSA:3.90.226.10 31 270 2.3E-78 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 Pfam PF00107 Zinc-binding dehydrogenase 179 297 1.8E-15 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 137 1.9E-18 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 SUPERFAMILY SSF50129 1 176 4.72E-35 T 17-03-2017 IPR011032 GroES-like SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 SUPERFAMILY SSF51735 144 303 3.57E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 Gene3D G3DSA:3.90.180.10 1 168 6.3E-40 T 17-03-2017 IPR011032 GroES-like SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 56 70 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS23145 f106df235d8ffdae03f9508715f59555 338 Gene3D G3DSA:3.40.50.720 169 301 2.8E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16170 76ce6e85906c0c0319e8741943849233 222 PIRSF PIRSF001296 8 222 4.6E-69 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS16170 76ce6e85906c0c0319e8741943849233 222 TIGRFAM TIGR00681 kdpC: K+-transporting ATPase, C subunit 14 216 6.3E-49 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS16170 76ce6e85906c0c0319e8741943849233 222 Pfam PF02669 K+-transporting ATPase, c chain 14 216 7.6E-66 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS16170 76ce6e85906c0c0319e8741943849233 222 Hamap MF_00276 Potassium-transporting ATPase KdpC subunit [kdpC]. 9 218 32.699 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 Gene3D G3DSA:1.10.10.10 147 245 8.9E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 Pfam PF00072 Response regulator receiver domain 22 131 3.2E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 SMART SM00448 20 131 1.4E-41 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 Pfam PF00486 Transcriptional regulatory protein, C terminal 171 245 5.7E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 SUPERFAMILY SSF46894 147 245 2.15E-26 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 Gene3D G3DSA:3.40.50.2300 17 142 1.0E-41 T 17-03-2017 SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 SUPERFAMILY SSF52172 16 143 6.55E-43 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS42295 9185e06bef7742c10cc23f8205c7decd 248 SMART SM00862 170 245 1.2E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS36725 803fba9ea0dd6d7e34d64548687be64e 514 Pfam PF07905 Purine catabolism regulatory protein-like family 16 135 5.5E-25 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS36725 803fba9ea0dd6d7e34d64548687be64e 514 Pfam PF13556 PucR C-terminal helix-turn-helix domain 455 512 4.7E-20 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS33550 37bd251b795909eb940b02a08ac97d0c 804 Pfam PF02687 FtsX-like permease family 687 796 3.4E-9 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS33550 37bd251b795909eb940b02a08ac97d0c 804 Pfam PF02687 FtsX-like permease family 215 334 1.6E-6 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 SUPERFAMILY SSF90123 6 315 2.35E-71 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 SMART SM00382 363 549 1.5E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 Pfam PF00664 ABC transporter transmembrane region 18 287 4.2E-43 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 SUPERFAMILY SSF52540 334 573 3.07E-80 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 ProSitePatterns PS00211 ABC transporters family signature. 475 489 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 Gene3D G3DSA:3.40.50.300 336 567 2.0E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 Pfam PF00005 ABC transporter 354 501 1.6E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30115 927cdcde002bbdb1f4d3a1cc8e5b3374 580 Gene3D G3DSA:1.20.1560.10 7 320 1.1E-65 T 17-03-2017 SHXM_RS29320 6a79ab2e3a75a2bcd73911237c078184 453 Gene3D G3DSA:3.90.1150.10 323 447 6.8E-34 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS29320 6a79ab2e3a75a2bcd73911237c078184 453 SUPERFAMILY SSF53383 17 447 9.79E-120 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS29320 6a79ab2e3a75a2bcd73911237c078184 453 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 250 287 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS29320 6a79ab2e3a75a2bcd73911237c078184 453 Gene3D G3DSA:3.40.640.10 70 322 1.1E-80 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS29320 6a79ab2e3a75a2bcd73911237c078184 453 Pfam PF00202 Aminotransferase class-III 36 445 6.6E-100 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 Gene3D G3DSA:2.10.150.10 107 189 2.0E-31 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 Pfam PF00547 Urease, gamma subunit 2 99 3.9E-35 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 Pfam PF00699 Urease beta subunit 108 189 3.5E-28 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 TIGRFAM TIGR00193 urease_gam: urease, gamma subunit 2 100 1.6E-32 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 SUPERFAMILY SSF51278 107 189 7.59E-29 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 SUPERFAMILY SSF54111 2 101 1.05E-32 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 Gene3D G3DSA:3.30.280.10 2 99 3.4E-36 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40510 0ad985979e1b8b34ee42bde844578998 200 ProDom PD002319 SUBUNIT GAMMA HYDROLASE UREASE UREA AMIDOHYDROLASE UREASE ALPHA GAMMA/BETA METAL-BINDING 9 99 1.0E-17 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS16220 3dc1592f3661256a1a502458d859313a 348 Pfam PF01872 RibD C-terminal domain 64 232 5.7E-36 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS16220 3dc1592f3661256a1a502458d859313a 348 Gene3D G3DSA:3.40.430.10 42 264 7.3E-55 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS16220 3dc1592f3661256a1a502458d859313a 348 SUPERFAMILY SSF53597 63 247 1.66E-45 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS34915 5a670fe9d52ac0bbb9025f9b1656a486 161 Pfam PF03259 Roadblock/LC7 domain 18 119 1.1E-11 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS34915 5a670fe9d52ac0bbb9025f9b1656a486 161 Gene3D G3DSA:3.30.450.30 12 145 1.6E-14 T 17-03-2017 SHXM_RS34915 5a670fe9d52ac0bbb9025f9b1656a486 161 SMART SM00960 18 121 2.1E-13 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS34915 5a670fe9d52ac0bbb9025f9b1656a486 161 SUPERFAMILY SSF103196 13 150 7.67E-21 T 17-03-2017 SHXM_RS35585 a566cd77ca90a9312f9fd119b1a9bfc9 293 Pfam PF13560 Helix-turn-helix domain 19 78 9.7E-13 T 17-03-2017 SHXM_RS35585 a566cd77ca90a9312f9fd119b1a9bfc9 293 SUPERFAMILY SSF47413 19 77 3.94E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35585 a566cd77ca90a9312f9fd119b1a9bfc9 293 Gene3D G3DSA:1.10.260.40 17 78 2.8E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22120 88fd66f6cc23d8b90e3e6927d38f0a91 218 Pfam PF00975 Thioesterase domain 27 130 1.5E-18 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS22120 88fd66f6cc23d8b90e3e6927d38f0a91 218 Gene3D G3DSA:3.40.50.1820 17 193 6.3E-16 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22120 88fd66f6cc23d8b90e3e6927d38f0a91 218 SUPERFAMILY SSF53474 13 198 3.21E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19785 cb3c22ee518b339d4a112f5831c10541 244 SUPERFAMILY SSF53335 8 236 1.53E-43 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS19785 cb3c22ee518b339d4a112f5831c10541 244 Gene3D G3DSA:3.40.50.150 7 237 8.8E-50 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS19785 cb3c22ee518b339d4a112f5831c10541 244 Pfam PF08241 Methyltransferase domain 18 121 1.2E-22 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS29235 15bad882b5bc9bfe545f9bda78036e40 181 Gene3D G3DSA:3.40.50.2020 5 178 9.0E-49 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS29235 15bad882b5bc9bfe545f9bda78036e40 181 TIGRFAM TIGR00336 pyrE: orotate phosphoribosyltransferase 15 162 3.5E-34 T 17-03-2017 IPR004467 Orotate phosphoribosyl transferase domain GO:0004588 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS29235 15bad882b5bc9bfe545f9bda78036e40 181 Hamap MF_01208 Orotate phosphoribosyltransferase [pyrE]. 1 181 25.402 T 17-03-2017 IPR023031 Orotate phosphoribosyltransferase GO:0004588|GO:0006221 KEGG: 00240+2.4.2.10|KEGG: 00983+2.4.2.10|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS29235 15bad882b5bc9bfe545f9bda78036e40 181 Pfam PF00156 Phosphoribosyl transferase domain 76 161 1.8E-10 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS29235 15bad882b5bc9bfe545f9bda78036e40 181 SUPERFAMILY SSF53271 6 177 5.24E-36 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 Gene3D G3DSA:3.40.50.720 10 252 5.6E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 88 99 1.4E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 1.4E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 1.4E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 14 203 3.8E-4 T 17-03-2017 SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 20 250 9.3E-62 T 17-03-2017 SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 15 32 3.8E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 3.8E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 88 99 3.8E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 3.8E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 3.8E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 3.8E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 147 175 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS38025 606ab296fdecc7ec46a65f3bea062501 256 SUPERFAMILY SSF51735 14 251 5.29E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 Gene3D G3DSA:3.40.50.970 359 538 1.6E-59 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 Gene3D G3DSA:3.40.50.1220 187 337 8.7E-24 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 424 443 - T 17-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 SUPERFAMILY SSF52518 364 540 3.04E-56 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 Gene3D G3DSA:3.40.50.970 8 184 9.8E-59 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 388 533 1.9E-40 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 SUPERFAMILY SSF52467 159 343 3.54E-26 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 SUPERFAMILY SSF52518 8 183 1.27E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 9 175 1.8E-52 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS40525 d65d9d1da54326e6f3dc598cc9eb5e78 557 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 194 320 3.1E-18 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS48520 eeca12958c4f7a3fc4a996e589f02d26 255 Pfam PF00005 ABC transporter 22 172 8.0E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS48520 eeca12958c4f7a3fc4a996e589f02d26 255 SUPERFAMILY SSF52540 6 230 3.9E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48520 eeca12958c4f7a3fc4a996e589f02d26 255 ProSitePatterns PS00211 ABC transporters family signature. 144 158 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48520 eeca12958c4f7a3fc4a996e589f02d26 255 SMART SM00382 31 229 4.7E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS48520 eeca12958c4f7a3fc4a996e589f02d26 255 Gene3D G3DSA:3.40.50.300 4 230 4.6E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32745 a0e8d746d7478ae92217de0a72680892 120 Gene3D G3DSA:3.10.180.10 6 118 1.6E-38 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS32745 a0e8d746d7478ae92217de0a72680892 120 SUPERFAMILY SSF54593 1 119 1.41E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS06010 5c2239fa88340f0786e78b18d7d10e60 484 Pfam PF00144 Beta-lactamase 38 302 2.8E-40 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS06010 5c2239fa88340f0786e78b18d7d10e60 484 Gene3D G3DSA:3.40.710.10 9 314 2.9E-52 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS06010 5c2239fa88340f0786e78b18d7d10e60 484 SUPERFAMILY SSF56601 3 321 9.21E-77 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS00470 b0b74abef3f685d67f6855c815f2f851 399 Gene3D G3DSA:3.40.50.150 19 267 2.1E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00470 b0b74abef3f685d67f6855c815f2f851 399 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 113 224 1.2E-15 T 17-03-2017 SHXM_RS00470 b0b74abef3f685d67f6855c815f2f851 399 TIGRFAM TIGR04188 methyltr_grsp: methyltransferase, ATP-grasp peptide maturase system 17 385 3.3E-127 T 17-03-2017 IPR026448 Methyltransferase, ATP-grasp peptide maturase system SHXM_RS00470 b0b74abef3f685d67f6855c815f2f851 399 SUPERFAMILY SSF53335 88 229 3.34E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00470 b0b74abef3f685d67f6855c815f2f851 399 SUPERFAMILY SSF53335 8 46 3.34E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24675 b09d9f032713d46b1c3529a5d2decac2 295 Pfam PF02237 Biotin protein ligase C terminal domain 240 287 7.7E-11 T 17-03-2017 IPR003142 Biotin protein ligase, C-terminal GO:0006464 KEGG: 00780+6.3.4.15|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24675 b09d9f032713d46b1c3529a5d2decac2 295 TIGRFAM TIGR00121 birA_ligase: biotin--[acetyl-CoA-carboxylase] ligase 45 287 5.8E-38 T 17-03-2017 IPR004408 Biotin--acetyl-CoA-carboxylase ligase GO:0004077|GO:0006464 Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24675 b09d9f032713d46b1c3529a5d2decac2 295 Gene3D G3DSA:3.30.930.10 40 222 4.7E-50 T 17-03-2017 SHXM_RS24675 b09d9f032713d46b1c3529a5d2decac2 295 Pfam PF03099 Biotin/lipoate A/B protein ligase family 52 174 8.3E-10 T 17-03-2017 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 SHXM_RS24675 b09d9f032713d46b1c3529a5d2decac2 295 SUPERFAMILY SSF55681 37 221 5.77E-42 T 17-03-2017 SHXM_RS24675 b09d9f032713d46b1c3529a5d2decac2 295 Gene3D G3DSA:2.30.30.100 241 285 2.2E-5 T 17-03-2017 SHXM_RS31190 01f58210cc9d76d98566da86a3f2c183 115 Hamap MF_01331_B 50S ribosomal protein L22 [rplV]. 1 111 30.154 T 17-03-2017 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31190 01f58210cc9d76d98566da86a3f2c183 115 Gene3D G3DSA:3.90.470.10 1 112 1.0E-42 T 17-03-2017 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31190 01f58210cc9d76d98566da86a3f2c183 115 SUPERFAMILY SSF54843 1 112 1.83E-42 T 17-03-2017 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31190 01f58210cc9d76d98566da86a3f2c183 115 TIGRFAM TIGR01044 rplV_bact: ribosomal protein uL22 5 108 2.4E-45 T 17-03-2017 IPR005727 Ribosomal protein L22, bacterial/chloroplast-type GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31190 01f58210cc9d76d98566da86a3f2c183 115 ProSitePatterns PS00464 Ribosomal protein L22 signature. 84 108 - T 17-03-2017 IPR018260 Ribosomal protein L22/L17, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31190 01f58210cc9d76d98566da86a3f2c183 115 Pfam PF00237 Ribosomal protein L22p/L17e 8 108 4.0E-33 T 17-03-2017 IPR001063 Ribosomal protein L22/L17 GO:0003735|GO:0005840|GO:0006412 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 123 196 9.5E-8 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 351 432 1.3E-8 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 PRINTS PR01185 Integrin alpha subunit signature 108 128 5.7E-6 T 17-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 PRINTS PR01185 Integrin alpha subunit signature 176 200 5.7E-6 T 17-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 PRINTS PR01185 Integrin alpha subunit signature 230 251 5.7E-6 T 17-03-2017 IPR000413 Integrin alpha chain GO:0007155|GO:0008305 Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SUPERFAMILY SSF69318 288 482 3.66E-23 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SUPERFAMILY SSF69318 48 335 3.14E-39 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SMART SM00191 226 282 29.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SMART SM00191 339 398 33.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SMART SM00191 111 169 2.0E-4 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SMART SM00191 410 464 3.7E-5 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 SMART SM00191 42 99 19.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 Gene3D G3DSA:2.130.10.130 190 305 3.5E-17 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 Gene3D G3DSA:2.130.10.130 331 483 1.7E-20 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 Gene3D G3DSA:2.130.10.130 49 189 1.1E-25 T 17-03-2017 SHXM_RS32065 60f8df2dc1c46e54744060c9e004e802 487 Pfam PF01839 FG-GAP repeat 235 260 3.8E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 SUPERFAMILY SSF46894 3 92 4.54E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 Gene3D G3DSA:1.25.40.10 107 222 2.0E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 Pfam PF00486 Transcriptional regulatory protein, C terminal 28 92 6.2E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 SUPERFAMILY SSF48452 95 252 1.14E-39 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 Gene3D G3DSA:1.10.10.10 11 93 3.6E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 SMART SM01043 99 244 5.5E-47 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 Pfam PF03704 Bacterial transcriptional activator domain 99 244 2.2E-46 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS06470 3bb6c1a1f69196711d80fc1d5f85d3a3 256 SMART SM00862 15 92 4.9E-7 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 Pfam PF00361 Proton-conducting membrane transporter 193 449 1.4E-54 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 422 448 1.9E-40 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 199 223 1.9E-40 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 365 384 1.9E-40 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 271 295 1.9E-40 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 149 168 1.9E-40 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30965 40fefd7f9e2126bc3aa05233e481a4d1 549 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 10 545 2.3E-158 T 17-03-2017 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS36450 2822f7666e71b814d35cffb2bb24cdf5 57 Hamap MF_00340 50S ribosomal protein L32 [rpmF]. 2 55 18.926 T 17-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36450 2822f7666e71b814d35cffb2bb24cdf5 57 Pfam PF01783 Ribosomal L32p protein family 2 56 3.1E-25 T 17-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36450 2822f7666e71b814d35cffb2bb24cdf5 57 TIGRFAM TIGR01031 rpmF_bact: ribosomal protein bL32 2 56 3.4E-26 T 17-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36450 2822f7666e71b814d35cffb2bb24cdf5 57 SUPERFAMILY SSF57829 2 57 4.88E-21 T 17-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 SHXM_RS03815 4e88eeb898e272fb31a5a5b22bdfee6c 610 SUPERFAMILY SSF48208 209 609 1.43E-109 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS03815 4e88eeb898e272fb31a5a5b22bdfee6c 610 Gene3D G3DSA:1.50.10.10 231 609 2.7E-99 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS03815 4e88eeb898e272fb31a5a5b22bdfee6c 610 Pfam PF00723 Glycosyl hydrolases family 15 237 558 5.3E-54 T 17-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 SUPERFAMILY SSF89082 163 250 4.45E-19 T 17-03-2017 IPR012925 TipAS antibiotic-recognition domain SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 Pfam PF13411 MerR HTH family regulatory protein 4 71 5.7E-17 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 Pfam PF07739 TipAS antibiotic-recognition domain 136 248 2.7E-24 T 17-03-2017 IPR012925 TipAS antibiotic-recognition domain SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 SMART SM00422 3 72 3.5E-21 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 Gene3D G3DSA:1.10.490.50 164 252 6.2E-22 T 17-03-2017 IPR012925 TipAS antibiotic-recognition domain SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 Gene3D G3DSA:1.10.1660.10 4 114 1.4E-28 T 17-03-2017 SHXM_RS00320 345d2f2359082c84d5c9df99aac37902 254 SUPERFAMILY SSF46955 3 109 4.03E-27 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS20760 44c52fd1aa24e0289656ddf5800fbbd2 262 Gene3D G3DSA:1.10.3720.10 4 250 4.3E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20760 44c52fd1aa24e0289656ddf5800fbbd2 262 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 76 249 1.2E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20760 44c52fd1aa24e0289656ddf5800fbbd2 262 SUPERFAMILY SSF161098 4 257 4.06E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46025 a460ef2afedda0523a68eb17158cb8fb 379 Pfam PF02515 CoA-transferase family III 6 371 1.0E-111 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS46025 a460ef2afedda0523a68eb17158cb8fb 379 Gene3D G3DSA:3.40.50.10540 2 215 1.8E-93 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS46025 a460ef2afedda0523a68eb17158cb8fb 379 Gene3D G3DSA:3.40.50.10540 305 377 1.8E-93 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS46025 a460ef2afedda0523a68eb17158cb8fb 379 SUPERFAMILY SSF89796 4 378 1.16E-117 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS46025 a460ef2afedda0523a68eb17158cb8fb 379 Gene3D G3DSA:3.30.1540.10 223 304 6.4E-28 T 17-03-2017 SHXM_RS06770 781f2c703d6dd393fe7864df47239c1b 475 PIRSF PIRSF002744 1 459 1.0E-91 T 17-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 SHXM_RS06770 781f2c703d6dd393fe7864df47239c1b 475 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 25 418 2.4E-32 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS04030 23ee59b32f2fc226e9920d00d912e894 438 Gene3D G3DSA:1.20.1250.20 25 232 2.2E-23 T 17-03-2017 SHXM_RS04030 23ee59b32f2fc226e9920d00d912e894 438 Gene3D G3DSA:1.20.1250.20 251 436 9.5E-17 T 17-03-2017 SHXM_RS04030 23ee59b32f2fc226e9920d00d912e894 438 SUPERFAMILY SSF103473 21 436 1.12E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04030 23ee59b32f2fc226e9920d00d912e894 438 Pfam PF07690 Major Facilitator Superfamily 261 433 6.0E-9 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS04030 23ee59b32f2fc226e9920d00d912e894 438 Pfam PF00083 Sugar (and other) transporter 29 242 7.7E-24 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS50305 98d4c0ccbf6b201bdef50439cdb6a418 323 SUPERFAMILY SSF161098 71 275 4.36E-38 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50305 98d4c0ccbf6b201bdef50439cdb6a418 323 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 90 290 9.1E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50305 98d4c0ccbf6b201bdef50439cdb6a418 323 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 71 133 5.4E-14 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS50305 98d4c0ccbf6b201bdef50439cdb6a418 323 Gene3D G3DSA:1.10.3720.10 67 290 5.4E-41 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 SUPERFAMILY SSF51604 116 360 2.62E-75 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 SUPERFAMILY SSF54826 11 131 9.76E-29 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 Gene3D G3DSA:3.20.20.120 129 359 1.8E-76 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 Pfam PF13378 Enolase C-terminal domain-like 153 354 7.1E-64 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 SMART SM00922 147 244 1.8E-26 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 23 127 8.3E-21 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 ProSitePatterns PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 194 225 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS41695 087d9a16c80cc26fafec23dd72ecfecf 362 Gene3D G3DSA:3.30.390.10 4 128 6.3E-34 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS11930 a22de4eb923e37f00c606cb8ca7f2c40 115 Pfam PF04237 YjbR 11 102 4.7E-28 T 17-03-2017 IPR007351 Uncharacterised protein YjbR SHXM_RS11930 a22de4eb923e37f00c606cb8ca7f2c40 115 SUPERFAMILY SSF142906 3 114 4.19E-38 T 17-03-2017 SHXM_RS34900 c5dc85914c1107db62240e3c9daa9f8e 189 ProSitePatterns PS01117 MarR-type HTH domain signature. 87 121 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS34900 c5dc85914c1107db62240e3c9daa9f8e 189 Gene3D G3DSA:1.10.10.10 29 160 8.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34900 c5dc85914c1107db62240e3c9daa9f8e 189 SMART SM00347 48 148 7.9E-19 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS34900 c5dc85914c1107db62240e3c9daa9f8e 189 Pfam PF01047 MarR family 59 112 3.2E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS34900 c5dc85914c1107db62240e3c9daa9f8e 189 SUPERFAMILY SSF46785 29 162 5.54E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 245 395 5.3E-37 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 Gene3D G3DSA:2.40.110.10 132 235 2.9E-40 T 17-03-2017 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 Gene3D G3DSA:1.10.540.10 2 131 1.1E-30 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 133 233 2.1E-18 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 8 127 6.4E-13 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 SUPERFAMILY SSF47203 243 401 1.47E-42 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 SUPERFAMILY SSF56645 2 258 1.02E-66 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10670 e95d15f2527f5330d83ecac138e356e0 410 Gene3D G3DSA:1.20.140.10 236 402 4.6E-48 T 17-03-2017 SHXM_RS35625 2a5201fb88ba8a2a818dd2f8ada74dae 121 SUPERFAMILY SSF53474 30 119 4.87E-13 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS35625 2a5201fb88ba8a2a818dd2f8ada74dae 121 Gene3D G3DSA:3.40.50.1820 28 119 1.8E-11 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS12390 d1fc25520986aebd117a3240d0c21001 150 SUPERFAMILY SSF48013 4 132 8.9E-41 T 17-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SHXM_RS12390 d1fc25520986aebd117a3240d0c21001 150 Gene3D G3DSA:1.10.940.10 2 132 3.2E-44 T 17-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SHXM_RS12390 d1fc25520986aebd117a3240d0c21001 150 Pfam PF01029 NusB family 6 132 3.3E-36 T 17-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SHXM_RS12390 d1fc25520986aebd117a3240d0c21001 150 TIGRFAM TIGR01951 nusB: transcription antitermination factor NusB 4 133 5.0E-40 T 17-03-2017 IPR011605 NusB antitermination factor GO:0006353 SHXM_RS12390 d1fc25520986aebd117a3240d0c21001 150 Hamap MF_00073 N utilization substance protein B homolog [nusB]. 2 137 22.806 T 17-03-2017 IPR011605 NusB antitermination factor GO:0006353 SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 SMART SM00244 21 179 7.1E-53 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 SUPERFAMILY SSF117892 52 186 1.96E-39 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 ProSitePatterns PS01270 Band 7 protein family signature. 135 163 - T 17-03-2017 IPR018080 Band 7/stomatin-like, conserved site SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 Pfam PF01145 SPFH domain / Band 7 family 25 194 1.5E-35 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 PRINTS PR00721 Stomatin signature 28 50 1.8E-31 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 PRINTS PR00721 Stomatin signature 76 97 1.8E-31 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 PRINTS PR00721 Stomatin signature 155 173 1.8E-31 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 PRINTS PR00721 Stomatin signature 131 154 1.8E-31 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 PRINTS PR00721 Stomatin signature 111 128 1.8E-31 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS17225 6f8e548995d24939e6aadce8c4121e71 319 PRINTS PR00721 Stomatin signature 174 195 1.8E-31 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 172 331 4.7E-22 T 17-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 PRINTS PR00738 Glycosyl hydrolase family 20 signature 195 216 6.8E-19 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 PRINTS PR00738 Glycosyl hydrolase family 20 signature 258 275 6.8E-19 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 PRINTS PR00738 Glycosyl hydrolase family 20 signature 446 462 6.8E-19 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 PRINTS PR00738 Glycosyl hydrolase family 20 signature 166 183 6.8E-19 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 PRINTS PR00738 Glycosyl hydrolase family 20 signature 318 331 6.8E-19 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 PRINTS PR00738 Glycosyl hydrolase family 20 signature 131 151 6.8E-19 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Pfam PF00754 F5/8 type C domain 532 637 1.0E-21 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Pfam PF00754 F5/8 type C domain 655 768 5.0E-26 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Gene3D G3DSA:3.30.379.10 6 157 2.0E-20 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 SUPERFAMILY SSF51445 172 488 2.86E-65 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 SUPERFAMILY SSF49785 530 644 3.47E-21 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 SUPERFAMILY SSF49785 652 772 3.4E-27 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 35 169 2.2E-18 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 SUPERFAMILY SSF55545 34 170 6.8E-19 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Gene3D G3DSA:2.60.120.260 522 646 2.9E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Gene3D G3DSA:2.60.120.260 647 773 5.1E-30 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48375 58c88c5f268971047ad4055890adb124 788 Gene3D G3DSA:3.20.20.80 158 495 1.2E-62 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 Gene3D G3DSA:1.10.10.10 124 214 3.8E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 SMART SM00421 153 210 2.1E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 SMART SM00448 2 115 2.3E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 SUPERFAMILY SSF52172 2 134 3.27E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 Gene3D G3DSA:3.40.50.2300 2 123 2.0E-35 T 17-03-2017 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 ProSitePatterns PS00622 LuxR-type HTH domain signature. 170 197 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 SUPERFAMILY SSF46894 145 214 5.78E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 Pfam PF00072 Response regulator receiver domain 4 116 8.4E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 5.1E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 5.1E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 5.1E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04550 97553749f5c722f3d979e703e196d280 219 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 209 4.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS01935 f19063dd090c8e08d89e4e8a343c3ae5 274 Gene3D G3DSA:1.10.3720.10 64 266 4.5E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01935 f19063dd090c8e08d89e4e8a343c3ae5 274 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 91 272 2.7E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01935 f19063dd090c8e08d89e4e8a343c3ae5 274 SUPERFAMILY SSF161098 69 255 9.65E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13415 484e2e1e53a9855312b8428906634038 290 Gene3D G3DSA:3.90.550.10 6 225 4.0E-26 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS13415 484e2e1e53a9855312b8428906634038 290 SUPERFAMILY SSF53448 5 242 7.69E-38 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS13415 484e2e1e53a9855312b8428906634038 290 Pfam PF00535 Glycosyl transferase family 2 6 125 4.3E-11 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS40055 7b229148e6f0f30d013eda90f42c8d61 143 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 17 137 7.0E-31 T 17-03-2017 IPR018727 Protein of unknown function DUF2267 SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 Pfam PF00501 AMP-binding enzyme 23 427 8.9E-103 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 Gene3D G3DSA:2.30.38.10 344 418 1.8E-30 T 17-03-2017 SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 Gene3D G3DSA:3.40.50.980 184 343 2.3E-49 T 17-03-2017 SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 Pfam PF13193 AMP-binding enzyme C-terminal domain 437 511 1.5E-16 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 SUPERFAMILY SSF56801 19 522 5.49E-149 T 17-03-2017 SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 Gene3D G3DSA:3.40.50.980 21 183 6.5E-33 T 17-03-2017 SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 ProSitePatterns PS00455 Putative AMP-binding domain signature. 178 189 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS25595 106013dd595734b40e55abb06ebeea38 527 Gene3D G3DSA:3.30.300.30 424 523 7.3E-31 T 17-03-2017 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 SUPERFAMILY SSF46955 128 226 2.7E-18 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 Pfam PF13411 MerR HTH family regulatory protein 129 195 7.8E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 Gene3D G3DSA:1.10.1660.10 128 238 2.1E-21 T 17-03-2017 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 Gene3D G3DSA:1.10.1660.10 12 119 1.1E-14 T 17-03-2017 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 SMART SM00422 128 197 3.5E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 SMART SM00422 8 76 5.8E-4 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 Pfam PF00376 MerR family regulatory protein 12 46 1.2E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS03665 c9dbf63c297ba2f03201e11b70d07eba 244 SUPERFAMILY SSF46955 12 118 4.53E-12 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 Gene3D G3DSA:1.10.10.10 1 84 1.3E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 Gene3D G3DSA:3.40.190.10 94 186 1.6E-12 T 17-03-2017 SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 8.3E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 Pfam PF03466 LysR substrate binding domain 90 271 9.2E-17 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 SUPERFAMILY SSF46785 1 84 5.45E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 SUPERFAMILY SSF53850 91 268 3.38E-17 T 17-03-2017 SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 4.9E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 4.9E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS39400 ef5f05d606a80093a3905056839e0b01 279 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 4.9E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS22880 a260c9282d2d2749324b6abfef70db9d 418 Gene3D G3DSA:3.40.50.2000 2 213 5.6E-23 T 17-03-2017 SHXM_RS22880 a260c9282d2d2749324b6abfef70db9d 418 SUPERFAMILY SSF53756 2 219 2.69E-41 T 17-03-2017 SHXM_RS22880 a260c9282d2d2749324b6abfef70db9d 418 SUPERFAMILY SSF53756 246 414 2.69E-41 T 17-03-2017 SHXM_RS22880 a260c9282d2d2749324b6abfef70db9d 418 Gene3D G3DSA:3.40.50.2000 299 360 2.3E-9 T 17-03-2017 SHXM_RS50335 305314e083986e691d75cfde4ab68688 259 SUPERFAMILY SSF52540 22 218 7.44E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50335 305314e083986e691d75cfde4ab68688 259 ProSitePatterns PS00211 ABC transporters family signature. 140 154 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS50335 305314e083986e691d75cfde4ab68688 259 Gene3D G3DSA:3.40.50.300 15 218 1.2E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50335 305314e083986e691d75cfde4ab68688 259 SMART SM00382 46 217 1.4E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS50335 305314e083986e691d75cfde4ab68688 259 Pfam PF00005 ABC transporter 37 167 1.4E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30410 59ae4d00ea0822ee245ec01cff48fea4 271 Pfam PF15698 Phosphatase 7 269 3.6E-113 T 17-03-2017 IPR031423 Uncharacterised phosphatase SCO2771 SHXM_RS19575 b7b7db20456e7f72864736e3448653c7 286 Gene3D G3DSA:3.90.550.10 10 221 2.4E-19 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS19575 b7b7db20456e7f72864736e3448653c7 286 Pfam PF13632 Glycosyl transferase family group 2 82 236 2.9E-8 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS19575 b7b7db20456e7f72864736e3448653c7 286 SUPERFAMILY SSF53448 5 215 6.88E-37 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS25320 157c50641f199fe13f3969217a7fc886 487 Pfam PF04434 SWIM zinc finger 69 95 3.5E-6 T 17-03-2017 IPR007527 Zinc finger, SWIM-type GO:0008270 SHXM_RS00725 43e20b402a613816cc84fc12ee98b062 170 Pfam PF13581 Histidine kinase-like ATPase domain 34 144 2.7E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00725 43e20b402a613816cc84fc12ee98b062 170 Gene3D G3DSA:3.30.565.10 46 147 5.8E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00725 43e20b402a613816cc84fc12ee98b062 170 SUPERFAMILY SSF55874 47 146 9.95E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS32285 a6e3af18047f7e8ce27844e65ebd1336 341 Gene3D G3DSA:3.40.50.1980 65 194 2.5E-6 T 17-03-2017 SHXM_RS32285 a6e3af18047f7e8ce27844e65ebd1336 341 SUPERFAMILY SSF53807 48 332 2.16E-27 T 17-03-2017 SHXM_RS32285 a6e3af18047f7e8ce27844e65ebd1336 341 Gene3D G3DSA:3.40.50.1980 195 334 7.6E-13 T 17-03-2017 SHXM_RS32285 a6e3af18047f7e8ce27844e65ebd1336 341 Pfam PF01497 Periplasmic binding protein 71 312 3.8E-15 T 17-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 SUPERFAMILY SSF52540 4 248 1.11E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 Gene3D G3DSA:3.40.50.300 4 251 9.0E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 Pfam PF00005 ABC transporter 23 177 2.9E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 229 295 2.3E-15 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 SMART SM00382 32 227 6.8E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS03535 3b018052731140707cfa7fb60afc92e7 350 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 227 313 5.7E-14 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 Pfam PF00248 Aldo/keto reductase family 24 288 2.0E-46 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 SUPERFAMILY SSF51430 17 288 2.62E-64 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 Gene3D G3DSA:3.20.20.100 17 288 6.6E-60 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 PRINTS PR00069 Aldo-keto reductase signature 52 76 1.2E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 PRINTS PR00069 Aldo-keto reductase signature 222 246 1.2E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 PRINTS PR00069 Aldo-keto reductase signature 117 135 1.2E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS14035 9d2723ad24167fd7dec8a4576e0b0af5 290 PRINTS PR00069 Aldo-keto reductase signature 152 169 1.2E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 Gene3D G3DSA:3.10.20.30 21 93 1.4E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 Pfam PF01799 [2Fe-2S] binding domain 92 180 8.4E-29 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 58 66 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 SUPERFAMILY SSF47741 103 185 1.96E-26 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 Gene3D G3DSA:1.10.150.120 94 185 4.8E-30 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 25 78 1.1E-8 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS03030 1dbf0766092562241453ecf0563eddd9 189 SUPERFAMILY SSF54292 22 97 4.72E-26 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 SUPERFAMILY SSF51556 79 100 4.77E-31 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 SUPERFAMILY SSF51556 191 509 4.77E-31 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 Gene3D G3DSA:2.30.40.10 26 81 6.9E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 Gene3D G3DSA:2.30.40.10 520 551 6.9E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 Gene3D G3DSA:3.20.20.140 224 492 3.4E-33 T 17-03-2017 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 Gene3D G3DSA:3.20.20.140 82 101 3.4E-33 T 17-03-2017 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 Pfam PF07969 Amidohydrolase family 71 549 3.5E-85 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 Gene3D G3DSA:2.30.40.10 493 519 3.4E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 SUPERFAMILY SSF51338 16 80 1.69E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS23970 555839c1a9f3f97340b26e38b390ac53 554 SUPERFAMILY SSF51338 509 551 1.69E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS05505 6d89553d7dbe95fa5f53ee27a13072a2 290 SUPERFAMILY SSF54637 180 271 8.46E-17 T 17-03-2017 IPR029069 HotDog domain SHXM_RS05505 6d89553d7dbe95fa5f53ee27a13072a2 290 Gene3D G3DSA:3.10.129.10 140 267 3.0E-12 T 17-03-2017 IPR029069 HotDog domain SHXM_RS21260 83d2f21427453a940948002e608dd11d 370 SUPERFAMILY SSF53613 31 325 1.43E-50 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS21260 83d2f21427453a940948002e608dd11d 370 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 269 282 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS21260 83d2f21427453a940948002e608dd11d 370 Pfam PF00294 pfkB family carbohydrate kinase 59 316 8.5E-32 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS21260 83d2f21427453a940948002e608dd11d 370 Gene3D G3DSA:3.40.1190.20 31 327 2.5E-56 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS29115 2b9143fb6cfe4592943b8807d495c74a 134 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 11 97 2.3E-10 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS29115 2b9143fb6cfe4592943b8807d495c74a 134 Gene3D G3DSA:2.30.110.10 11 132 1.9E-33 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS29115 2b9143fb6cfe4592943b8807d495c74a 134 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 13 131 2.5E-23 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS29115 2b9143fb6cfe4592943b8807d495c74a 134 SUPERFAMILY SSF50475 12 132 2.05E-27 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS11705 c68ff3705aec609e098c2138d75eac53 406 SUPERFAMILY SSF56300 168 401 3.07E-35 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS11705 c68ff3705aec609e098c2138d75eac53 406 Pfam PF00149 Calcineurin-like phosphoesterase 173 341 2.6E-8 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS11705 c68ff3705aec609e098c2138d75eac53 406 Gene3D G3DSA:3.60.21.10 173 353 5.7E-23 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS39300 1470851567ccb50e27756aa809e8b0a4 102 SUPERFAMILY SSF46955 17 93 2.2E-10 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS39300 1470851567ccb50e27756aa809e8b0a4 102 SMART SM00422 17 85 4.1E-4 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS39300 1470851567ccb50e27756aa809e8b0a4 102 Pfam PF13411 MerR HTH family regulatory protein 17 80 8.2E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS39300 1470851567ccb50e27756aa809e8b0a4 102 Gene3D G3DSA:1.10.1660.10 17 97 4.9E-11 T 17-03-2017 SHXM_RS27575 399d89a5b91cfb1e4aa8df25a0cab776 337 SUPERFAMILY SSF56747 155 246 2.29E-17 T 17-03-2017 SHXM_RS27575 399d89a5b91cfb1e4aa8df25a0cab776 337 SMART SM00942 266 328 8.7E-9 T 17-03-2017 IPR014820 Primase, C-terminal 1 SHXM_RS27575 399d89a5b91cfb1e4aa8df25a0cab776 337 SUPERFAMILY SSF56747 8 106 1.9E-8 T 17-03-2017 SHXM_RS27575 399d89a5b91cfb1e4aa8df25a0cab776 337 SMART SM00943 13 233 4.4E-34 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS27575 399d89a5b91cfb1e4aa8df25a0cab776 337 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 13 231 6.1E-40 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS22510 cf58f8b128a9e02359299100a4200026 330 SUPERFAMILY SSF46689 273 325 1.08E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22510 cf58f8b128a9e02359299100a4200026 330 Pfam PF12833 Helix-turn-helix domain 243 323 1.2E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS22510 cf58f8b128a9e02359299100a4200026 330 Gene3D G3DSA:1.10.10.60 273 327 1.0E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22510 cf58f8b128a9e02359299100a4200026 330 Gene3D G3DSA:1.10.10.60 223 272 3.4E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22510 cf58f8b128a9e02359299100a4200026 330 Pfam PF14525 AraC-binding-like domain 20 196 2.6E-22 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS22510 cf58f8b128a9e02359299100a4200026 330 SMART SM00342 237 322 3.2E-25 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 171 190 8.5E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 159 8.5E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 98 109 8.5E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 Gene3D G3DSA:3.40.50.720 20 260 6.4E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23050 916f127fad9d33a6775756927025b204 261 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 21 238 1.0E-5 T 17-03-2017 SHXM_RS23050 916f127fad9d33a6775756927025b204 261 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 158 186 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS23050 916f127fad9d33a6775756927025b204 261 SUPERFAMILY SSF51735 21 260 1.16E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 192 209 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 225 245 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 161 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 98 109 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 22 39 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 190 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23050 916f127fad9d33a6775756927025b204 261 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 29 259 3.0E-61 T 17-03-2017 SHXM_RS44825 05700237c1d1c09e4c6e16a31c5dde40 277 SUPERFAMILY SSF50800 3 51 1.04E-16 T 17-03-2017 IPR011037 Pyruvate kinase-like, insert domain SHXM_RS44825 05700237c1d1c09e4c6e16a31c5dde40 277 SUPERFAMILY SSF50800 148 268 1.04E-16 T 17-03-2017 IPR011037 Pyruvate kinase-like, insert domain SHXM_RS44825 05700237c1d1c09e4c6e16a31c5dde40 277 SUPERFAMILY SSF141673 6 131 4.05E-32 T 17-03-2017 SHXM_RS44825 05700237c1d1c09e4c6e16a31c5dde40 277 Pfam PF03473 MOSC domain 141 265 2.3E-25 T 17-03-2017 IPR005302 Molybdenum cofactor sulfurase, C-terminal GO:0003824|GO:0030151|GO:0030170 SHXM_RS44825 05700237c1d1c09e4c6e16a31c5dde40 277 Pfam PF03476 MOSC N-terminal beta barrel domain 2 118 1.2E-30 T 17-03-2017 IPR005303 MOSC, N-terminal beta barrel SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Pfam PF13404 AsnC-type helix-turn-helix domain 11 52 4.9E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Pfam PF13404 AsnC-type helix-turn-helix domain 185 224 8.7E-8 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 SMART SM00344 11 116 3.0E-5 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 SMART SM00344 184 288 7.4E-8 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Gene3D G3DSA:3.30.70.920 75 144 3.7E-10 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Pfam PF01037 Lrp/AsnC ligand binding domain 76 144 1.3E-7 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Gene3D G3DSA:1.10.10.10 9 56 2.4E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 SUPERFAMILY SSF54909 72 144 2.28E-9 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Gene3D G3DSA:1.10.10.10 183 226 1.3E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 SUPERFAMILY SSF46785 181 225 4.49E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 Gene3D G3DSA:3.30.70.920 246 325 1.7E-4 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS45850 22df18923668bc04e28bcaec948a594f 353 SUPERFAMILY SSF54909 243 323 2.68E-5 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS26520 5c4d46e66c5db0b10b179ee8d79cd6ad 188 Gene3D G3DSA:1.20.120.450 3 166 3.3E-43 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS26520 5c4d46e66c5db0b10b179ee8d79cd6ad 188 SUPERFAMILY SSF109854 4 164 6.56E-38 T 17-03-2017 SHXM_RS26520 5c4d46e66c5db0b10b179ee8d79cd6ad 188 Pfam PF04978 Protein of unknown function (DUF664) 17 165 1.3E-40 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS34580 a40afcddf95348816f9819625c821235 264 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 68 84 2.8E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34580 a40afcddf95348816f9819625c821235 264 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 54 68 2.8E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34580 a40afcddf95348816f9819625c821235 264 SMART SM00866 114 254 2.4E-42 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS34580 a40afcddf95348816f9819625c821235 264 Gene3D G3DSA:1.10.10.10 28 91 4.5E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34580 a40afcddf95348816f9819625c821235 264 SMART SM00345 37 94 1.4E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34580 a40afcddf95348816f9819625c821235 264 Gene3D G3DSA:3.40.1410.10 92 261 2.5E-55 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS34580 a40afcddf95348816f9819625c821235 264 SUPERFAMILY SSF64288 82 261 4.87E-54 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS34580 a40afcddf95348816f9819625c821235 264 SUPERFAMILY SSF46785 28 98 1.25E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34580 a40afcddf95348816f9819625c821235 264 Pfam PF07702 UTRA domain 114 254 9.6E-42 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS34580 a40afcddf95348816f9819625c821235 264 Pfam PF00392 Bacterial regulatory proteins, gntR family 45 94 4.9E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS42950 bcd143c436c2dac68903242d5e66bbdf 360 Pfam PF01032 FecCD transport family 35 352 1.0E-92 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS42950 bcd143c436c2dac68903242d5e66bbdf 360 Gene3D G3DSA:1.10.3470.10 27 355 6.1E-107 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS42950 bcd143c436c2dac68903242d5e66bbdf 360 SUPERFAMILY SSF81345 24 354 1.26E-81 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 288 322 0.0034 T 17-03-2017 IPR019931 LPXTG cell wall anchor domain SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 Pfam PF00089 Trypsin 41 263 5.5E-34 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 Gene3D G3DSA:2.40.10.10 137 268 1.3E-22 T 17-03-2017 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 Gene3D G3DSA:2.40.10.10 36 73 8.1E-12 T 17-03-2017 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 SUPERFAMILY SSF50494 21 268 1.75E-48 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 Gene3D G3DSA:2.40.10.10 74 136 5.1E-20 T 17-03-2017 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 SMART SM00020 35 263 6.7E-40 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 77 82 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 210 222 8.4E-14 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 67 82 8.4E-14 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS26085 a4f5e06d4a2123e0530111175e338397 327 PRINTS PR00722 Chymotrypsin serine protease family (S1) signature 127 141 8.4E-14 T 17-03-2017 IPR001314 Peptidase S1A, chymotrypsin family GO:0004252|GO:0006508 SHXM_RS44210 6c8d751e28d389942176f2de0476e3e2 135 Pfam PF01042 Endoribonuclease L-PSP 20 128 2.7E-20 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS44210 6c8d751e28d389942176f2de0476e3e2 135 SUPERFAMILY SSF55298 19 131 1.73E-30 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS44210 6c8d751e28d389942176f2de0476e3e2 135 Gene3D G3DSA:3.30.1330.40 4 132 6.2E-40 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 Pfam PF12697 Alpha/beta hydrolase family 36 258 1.4E-14 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 SUPERFAMILY SSF53474 15 261 2.84E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 Gene3D G3DSA:3.40.50.1820 14 261 3.0E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 57 72 1.5E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 228 242 1.5E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 115 128 1.5E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS46915 7b4459e49f9b19961285b0148a176f8e 266 PRINTS PR00111 Alpha/beta hydrolase fold signature 101 114 1.5E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS06330 09760368bde25bf966c99d8fb35937b4 122 PIRSF PIRSF019455 1 121 7.2E-21 T 17-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SHXM_RS06330 09760368bde25bf966c99d8fb35937b4 122 Gene3D G3DSA:1.10.10.10 1 79 4.8E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06330 09760368bde25bf966c99d8fb35937b4 122 SUPERFAMILY SSF46785 1 115 6.36E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06330 09760368bde25bf966c99d8fb35937b4 122 Pfam PF03965 Penicillinase repressor 4 114 1.6E-27 T 17-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SHXM_RS34600 88d33da82f34e8fa00cbcf0b038b9111 519 SUPERFAMILY SSF51445 21 338 5.79E-77 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS34600 88d33da82f34e8fa00cbcf0b038b9111 519 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 40 334 5.7E-71 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS34600 88d33da82f34e8fa00cbcf0b038b9111 519 Gene3D G3DSA:3.20.20.300 19 336 7.2E-91 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 SUPERFAMILY SSF51445 65 453 1.68E-105 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 Gene3D G3DSA:3.20.20.300 113 442 6.8E-111 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 SUPERFAMILY SSF52279 456 640 1.31E-12 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 338 355 - T 17-03-2017 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 77 417 3.5E-112 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 Gene3D G3DSA:3.40.50.1700 443 638 3.9E-15 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS22485 58bb399aa517e4dd0846ff5db56391f8 640 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 456 640 8.3E-13 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 ProSitePatterns PS00623 GMC oxidoreductases signature 1. 139 162 - T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 Pfam PF05199 GMC oxidoreductase 473 525 1.3E-13 T 17-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 Gene3D G3DSA:3.50.50.60 471 532 2.4E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 Gene3D G3DSA:3.50.50.60 39 183 2.4E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 Gene3D G3DSA:3.50.50.60 246 352 2.4E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 Gene3D G3DSA:3.30.410.10 188 244 1.1E-76 T 17-03-2017 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 Gene3D G3DSA:3.30.410.10 353 470 1.1E-76 T 17-03-2017 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 SUPERFAMILY SSF54373 349 479 3.73E-53 T 17-03-2017 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 SUPERFAMILY SSF51905 41 345 1.75E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03825 f85bb47a1ec90d4bfcee63df994cd990 539 SUPERFAMILY SSF51905 476 532 1.75E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14405 f13c619e5488773da50d038fa03a9bdc 358 SUPERFAMILY SSF63829 56 350 1.05E-13 T 17-03-2017 SHXM_RS14405 f13c619e5488773da50d038fa03a9bdc 358 Gene3D G3DSA:2.120.10.30 135 355 2.8E-15 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS26800 7609fc5ada27af93cd514540bae47e0a 166 PIRSF PIRSF037081 7 161 4.1E-18 T 17-03-2017 IPR017101 P-loop ATP/GTP binding protein, All4644, predicted SHXM_RS26800 7609fc5ada27af93cd514540bae47e0a 166 SUPERFAMILY SSF52540 7 124 2.05E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26800 7609fc5ada27af93cd514540bae47e0a 166 Gene3D G3DSA:3.40.50.300 10 134 4.9E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26800 7609fc5ada27af93cd514540bae47e0a 166 Pfam PF13671 AAA domain 10 130 9.6E-16 T 17-03-2017 SHXM_RS39060 accaa03a06d402b208c6af0d9d4500aa 322 Gene3D G3DSA:3.40.1190.20 5 312 1.8E-76 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS39060 accaa03a06d402b208c6af0d9d4500aa 322 Pfam PF00294 pfkB family carbohydrate kinase 8 302 3.3E-44 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS39060 accaa03a06d402b208c6af0d9d4500aa 322 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 254 267 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS39060 accaa03a06d402b208c6af0d9d4500aa 322 SUPERFAMILY SSF53613 6 303 3.74E-66 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS06280 6f5d15f0ff659afdc385cb2c09c916b4 298 SUPERFAMILY SSF51445 91 297 5.05E-65 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06280 6f5d15f0ff659afdc385cb2c09c916b4 298 Pfam PF01183 Glycosyl hydrolases family 25 96 280 2.4E-50 T 17-03-2017 IPR002053 Glycoside hydrolase, family 25 GO:0003796|GO:0009253|GO:0016998 SHXM_RS06280 6f5d15f0ff659afdc385cb2c09c916b4 298 Gene3D G3DSA:3.20.20.80 92 297 6.1E-72 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS06280 6f5d15f0ff659afdc385cb2c09c916b4 298 SMART SM00641 93 202 1.1E-41 T 17-03-2017 IPR018077 Glycoside hydrolase, family 25 subgroup SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 SMART SM00226 7 161 1.5E-52 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 SUPERFAMILY SSF52788 6 161 7.72E-48 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 Pfam PF01451 Low molecular weight phosphotyrosine protein phosphatase 9 155 1.1E-44 T 17-03-2017 IPR023485 Phosphotyrosine protein phosphatase I superfamily SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 52 68 8.6E-21 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 85 100 8.6E-21 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 9 26 8.6E-21 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 PRINTS PR00719 LMW phosphotyrosine protein phosphatase signature 133 148 8.6E-21 T 17-03-2017 IPR017867 Protein-tyrosine phosphatase, low molecular weight GO:0004725|GO:0006470 SHXM_RS27865 b1b451881532a1be9476a68fc61d32b4 203 Gene3D G3DSA:3.40.50.270 5 161 4.2E-52 T 17-03-2017 SHXM_RS16925 f832e105103d758edbd322bae965119f 297 SUPERFAMILY SSF161098 73 292 7.09E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS16925 f832e105103d758edbd322bae965119f 297 Gene3D G3DSA:1.10.3720.10 68 292 5.9E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS16925 f832e105103d758edbd322bae965119f 297 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 72 135 1.5E-14 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS16925 f832e105103d758edbd322bae965119f 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 92 292 2.4E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 SUPERFAMILY SSF46955 15 118 5.04E-11 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 Pfam PF00376 MerR family regulatory protein 15 49 3.7E-8 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 Gene3D G3DSA:1.10.1660.10 15 120 5.0E-13 T 17-03-2017 SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 Gene3D G3DSA:1.10.1660.10 144 250 2.6E-17 T 17-03-2017 SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 SUPERFAMILY SSF46955 144 249 1.42E-14 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 Pfam PF13411 MerR HTH family regulatory protein 144 208 2.5E-11 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 SMART SM00422 11 81 0.025 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS02415 668e294626e5923ad0cd6f046435e9c9 253 SMART SM00422 144 211 2.7E-4 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 SUPERFAMILY SSF53850 104 308 4.34E-28 T 17-03-2017 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 Gene3D G3DSA:3.40.190.10 105 187 1.8E-21 T 17-03-2017 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 Pfam PF03466 LysR substrate binding domain 104 307 1.6E-29 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 56 67 5.6E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 46 56 5.6E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 35 46 5.6E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 SUPERFAMILY SSF46785 19 102 2.26E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 20 79 4.4E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 Gene3D G3DSA:1.10.10.10 16 95 1.8E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03915 7a497f083f9f981d50acb556c32ce5a3 331 Gene3D G3DSA:3.40.190.10 188 281 3.1E-17 T 17-03-2017 SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 Gene3D G3DSA:2.60.120.260 646 766 7.4E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 SUPERFAMILY SSF55545 30 176 3.66E-15 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 Pfam PF00754 F5/8 type C domain 645 763 1.3E-17 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 31 175 2.6E-19 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 SUPERFAMILY SSF49785 642 766 2.2E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 Pfam PF07555 beta-N-acetylglucosaminidase 181 489 4.9E-109 T 17-03-2017 IPR011496 Beta-N-acetylglucosaminidase MetaCyc: PWY-7437 SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 Gene3D G3DSA:3.30.379.10 23 175 4.4E-20 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS48330 534dbddf67bb972ae2d99f094df5d33e 892 SUPERFAMILY SSF51445 179 497 3.37E-103 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 Gene3D G3DSA:1.10.1740.10 13 84 2.6E-14 T 17-03-2017 SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 Pfam PF04542 Sigma-70 region 2 21 81 1.1E-10 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 Gene3D G3DSA:1.10.10.10 108 171 1.1E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 SUPERFAMILY SSF88946 13 98 1.8E-14 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 17 168 8.6E-21 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 SUPERFAMILY SSF88659 111 168 8.07E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26140 cb39834c32cc85bfac84e983cd920ce4 238 Pfam PF08281 Sigma-70, region 4 116 167 1.3E-17 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 Gene3D G3DSA:3.40.50.720 4 242 9.1E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 9.0E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 204 224 9.0E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 9.0E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 9.0E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 9.0E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 9.0E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 180 0.006 T 17-03-2017 SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 SUPERFAMILY SSF51735 5 242 8.68E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 1.9E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 1.9E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 1.9E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09180 f20345672d7a7acb62a138b6f8d5a960 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 239 1.6E-62 T 17-03-2017 SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 ProSitePatterns PS00455 Putative AMP-binding domain signature. 204 215 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 Gene3D G3DSA:3.40.50.980 29 208 4.3E-38 T 17-03-2017 SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 Gene3D G3DSA:3.30.300.30 450 546 1.7E-34 T 17-03-2017 SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 Pfam PF13193 AMP-binding enzyme C-terminal domain 464 539 6.2E-24 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 Gene3D G3DSA:2.30.38.10 374 446 5.5E-25 T 17-03-2017 SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 SUPERFAMILY SSF56801 26 546 4.45E-153 T 17-03-2017 SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 Gene3D G3DSA:3.40.50.980 209 361 4.8E-37 T 17-03-2017 SHXM_RS16375 d684d06b8bcaf60ccb25a201a334b42e 547 Pfam PF00501 AMP-binding enzyme 31 454 1.2E-98 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 SUPERFAMILY SSF55447 225 327 1.11E-23 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 SMART SM01092 226 324 3.8E-26 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 Gene3D G3DSA:3.30.43.10 1 51 4.5E-18 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 Gene3D G3DSA:3.30.465.10 157 219 2.2E-32 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 Gene3D G3DSA:3.30.465.10 56 113 2.2E-32 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 Gene3D G3DSA:3.30.390.50 224 328 1.0E-29 T 17-03-2017 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 219 3.9E-50 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 SUPERFAMILY SSF56176 1 219 4.09E-57 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS45485 db1f654612c8ce6a1b469f72146c9e96 330 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 227 323 4.2E-15 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS02485 4a3ed67de5e8c1e42397c7ad2b4c8101 303 Gene3D G3DSA:3.40.50.720 1 235 2.6E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02485 4a3ed67de5e8c1e42397c7ad2b4c8101 303 SUPERFAMILY SSF51735 1 286 1.23E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02485 4a3ed67de5e8c1e42397c7ad2b4c8101 303 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 212 1.1E-11 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS47620 4e540ea628e6fa49d83cd50e8390b802 177 SUPERFAMILY SSF55729 1 157 1.08E-34 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS47620 4e540ea628e6fa49d83cd50e8390b802 177 Pfam PF13302 Acetyltransferase (GNAT) domain 8 150 1.9E-26 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS47620 4e540ea628e6fa49d83cd50e8390b802 177 Gene3D G3DSA:3.40.630.30 1 157 6.3E-42 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38875 5f0bb892a9be9fecdd4b1ed52acf45ec 86 Gene3D G3DSA:3.20.20.40 1 86 3.5E-33 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38875 5f0bb892a9be9fecdd4b1ed52acf45ec 86 Pfam PF01341 Glycosyl hydrolases family 6 2 86 9.8E-22 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38875 5f0bb892a9be9fecdd4b1ed52acf45ec 86 SUPERFAMILY SSF51989 3 86 9.03E-24 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38875 5f0bb892a9be9fecdd4b1ed52acf45ec 86 PRINTS PR00733 Glycosyl hydrolase family 6 signature 62 77 2.0E-6 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38875 5f0bb892a9be9fecdd4b1ed52acf45ec 86 PRINTS PR00733 Glycosyl hydrolase family 6 signature 34 47 2.0E-6 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS28470 2ef7c60274a8e9044ca417cbc5c40a20 279 SUPERFAMILY SSF47413 33 79 7.7E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28470 2ef7c60274a8e9044ca417cbc5c40a20 279 Gene3D G3DSA:1.10.260.40 37 78 1.3E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS17590 4e976226b9851919d0e676fbccaa2927 295 SUPERFAMILY SSF51197 32 293 1.83E-60 T 17-03-2017 SHXM_RS17590 4e976226b9851919d0e676fbccaa2927 295 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 43 258 7.7E-37 T 17-03-2017 IPR008775 Phytanoyl-CoA dioxygenase SHXM_RS17590 4e976226b9851919d0e676fbccaa2927 295 Gene3D G3DSA:2.60.120.620 31 274 7.2E-54 T 17-03-2017 SHXM_RS17590 4e976226b9851919d0e676fbccaa2927 295 TIGRFAM TIGR02408 ectoine_ThpD: ectoine hydroxylase 19 295 1.3E-151 T 17-03-2017 IPR012774 Ectoine dioxygenase GO:0016706|GO:0055114 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Pfam PF13620 Carboxypeptidase regulatory-like domain 706 786 1.5E-12 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Pfam PF13620 Carboxypeptidase regulatory-like domain 623 699 1.1E-9 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Pfam PF13620 Carboxypeptidase regulatory-like domain 791 867 1.0E-11 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 SUPERFAMILY SSF103473 32 237 9.68E-68 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 SUPERFAMILY SSF103473 286 458 9.68E-68 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 SUPERFAMILY SSF103473 508 532 9.68E-68 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 SUPERFAMILY SSF49464 705 797 5.89E-12 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Gene3D G3DSA:2.60.40.10 791 845 2.4E-13 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 SUPERFAMILY SSF49478 791 852 1.73E-12 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 49 530 7.4E-69 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 PRINTS PR01036 Tetracycline resistance protein TetB signature 439 458 3.9E-9 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 PRINTS PR01036 Tetracycline resistance protein TetB signature 173 197 3.9E-9 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 PRINTS PR01036 Tetracycline resistance protein TetB signature 143 163 3.9E-9 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 PRINTS PR01036 Tetracycline resistance protein TetB signature 52 76 3.9E-9 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Gene3D G3DSA:1.20.1250.20 292 460 1.3E-23 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Gene3D G3DSA:1.20.1250.20 53 223 8.4E-31 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Gene3D G3DSA:1.20.1250.20 509 534 1.3E-23 T 17-03-2017 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Gene3D G3DSA:2.60.40.1120 622 701 1.2E-9 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Pfam PF07690 Major Facilitator Superfamily 236 448 3.9E-18 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Pfam PF07690 Major Facilitator Superfamily 53 220 2.0E-32 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 Gene3D G3DSA:2.60.40.1120 705 786 7.3E-14 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS27385 71f38171450346f20b1ca839b16b151e 873 SUPERFAMILY SSF49464 622 699 2.24E-10 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS01510 e2f3d49af46fdeb587b0278d0113ef33 369 SUPERFAMILY SSF51735 7 164 1.69E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01510 e2f3d49af46fdeb587b0278d0113ef33 369 SUPERFAMILY SSF55347 142 298 2.13E-28 T 17-03-2017 SHXM_RS01510 e2f3d49af46fdeb587b0278d0113ef33 369 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 14 130 9.3E-18 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS01510 e2f3d49af46fdeb587b0278d0113ef33 369 Gene3D G3DSA:3.30.360.10 154 357 2.3E-27 T 17-03-2017 SHXM_RS01510 e2f3d49af46fdeb587b0278d0113ef33 369 Gene3D G3DSA:3.40.50.720 9 153 8.6E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 Gene3D G3DSA:1.10.260.40 1 40 1.6E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 40 2.6E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 SMART SM00354 1 62 6.3E-18 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 Gene3D G3DSA:3.40.50.2300 164 321 1.5E-47 T 17-03-2017 SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 Gene3D G3DSA:3.40.50.2300 49 163 5.6E-25 T 17-03-2017 SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 SUPERFAMILY SSF53822 52 323 5.44E-62 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 Pfam PF13377 Periplasmic binding protein-like domain 165 319 4.0E-35 T 17-03-2017 SHXM_RS05420 586950014fb3ee8d1adaf3c43f903b6c 325 SUPERFAMILY SSF47413 1 43 8.96E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 SUPERFAMILY SSF52172 1 162 4.41E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 SUPERFAMILY SSF46894 134 225 3.12E-27 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 SMART SM00448 2 115 7.1E-41 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 Gene3D G3DSA:3.40.50.2300 1 123 3.1E-40 T 17-03-2017 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 SMART SM00862 149 225 4.4E-26 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 225 2.0E-24 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 Pfam PF00072 Response regulator receiver domain 4 115 2.1E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS11860 54c6fe9fdf5de3c357ecfec58ce1e2c6 228 Gene3D G3DSA:1.10.10.10 133 226 2.9E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 Pfam PF00106 short chain dehydrogenase 34 230 1.5E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 SUPERFAMILY SSF51735 30 283 8.8E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 Gene3D G3DSA:3.40.50.720 30 278 3.9E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 34 51 6.1E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 164 6.1E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 104 115 6.1E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20120 8cb4911f6f1c6bd52edb5472594161ab 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 207 224 6.1E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 Gene3D G3DSA:1.20.120.530 107 246 2.8E-24 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 SUPERFAMILY SSF48008 109 243 1.67E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 SMART SM00895 112 238 5.2E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 Pfam PF07729 FCD domain 112 237 1.6E-23 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 Gene3D G3DSA:1.10.10.10 22 91 2.1E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 SUPERFAMILY SSF46785 22 91 9.88E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 47 61 1.0E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 61 77 1.0E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 SMART SM00345 28 87 5.6E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS48455 20aa14d7edda222e2361d70eb1651d77 259 Pfam PF00392 Bacterial regulatory proteins, gntR family 25 87 4.2E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38290 6aff5bc60750a09c7af46aeac1bf1574 238 Gene3D G3DSA:3.30.70.1100 140 237 5.4E-41 T 17-03-2017 SHXM_RS38290 6aff5bc60750a09c7af46aeac1bf1574 238 Pfam PF06778 Chlorite dismutase 40 227 1.1E-74 T 17-03-2017 IPR010644 Putative heme-dependent peroxidase/Chlorite dismutase SHXM_RS38290 6aff5bc60750a09c7af46aeac1bf1574 238 SUPERFAMILY SSF54909 18 237 4.29E-76 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS38290 6aff5bc60750a09c7af46aeac1bf1574 238 Gene3D G3DSA:3.30.70.1030 24 139 1.5E-28 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 SUPERFAMILY SSF52777 778 1007 1.33E-35 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 SUPERFAMILY SSF52777 586 769 4.89E-31 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 SUPERFAMILY SSF56801 5 486 5.36E-102 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 SMART SM00823 Phosphopantetheine attachment site 499 568 0.0018 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Pfam PF00668 Condensation domain 586 884 1.1E-43 T 17-03-2017 IPR001242 Condensation domain SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Gene3D G3DSA:1.10.1200.10 502 567 2.3E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Pfam PF00550 Phosphopantetheine attachment site 501 564 3.9E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Gene3D G3DSA:3.30.300.30 387 501 1.7E-27 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 SUPERFAMILY SSF47336 493 565 1.57E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 ProSitePatterns PS00455 Putative AMP-binding domain signature. 132 143 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Pfam PF00501 AMP-binding enzyme 11 391 6.0E-54 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Gene3D G3DSA:3.40.50.980 5 152 1.2E-17 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Gene3D G3DSA:3.40.50.980 153 302 1.1E-32 T 17-03-2017 SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Pfam PF13193 AMP-binding enzyme C-terminal domain 401 474 2.8E-10 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS50010 95942b35cc5f3ddc08272a9a7d744130 1012 Gene3D G3DSA:2.30.38.10 303 385 1.0E-12 T 17-03-2017 SHXM_RS06915 9aab47aa51422d0142afba5adf1346c1 435 Gene3D G3DSA:3.30.420.40 81 232 2.3E-33 T 17-03-2017 SHXM_RS06915 9aab47aa51422d0142afba5adf1346c1 435 SUPERFAMILY SSF46785 12 75 2.52E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06915 9aab47aa51422d0142afba5adf1346c1 435 Gene3D G3DSA:1.10.10.10 11 80 4.7E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06915 9aab47aa51422d0142afba5adf1346c1 435 Pfam PF00480 ROK family 86 401 5.4E-37 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS06915 9aab47aa51422d0142afba5adf1346c1 435 Gene3D G3DSA:3.30.420.40 233 385 3.2E-40 T 17-03-2017 SHXM_RS06915 9aab47aa51422d0142afba5adf1346c1 435 SUPERFAMILY SSF53067 83 406 1.1E-46 T 17-03-2017 SHXM_RS36900 c43d553393b5096a04cd714b449ed7f7 167 Pfam PF14530 Domain of unknown function (DUF4439) 19 149 1.3E-45 T 17-03-2017 IPR029447 Domain of unknown function DUF4439 SHXM_RS36900 c43d553393b5096a04cd714b449ed7f7 167 SUPERFAMILY SSF47240 15 149 2.07E-37 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS36900 c43d553393b5096a04cd714b449ed7f7 167 Gene3D G3DSA:1.20.1260.10 15 139 2.5E-44 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS07610 8342b4cafa5cf536757d076c2b14bd3c 328 Gene3D G3DSA:3.20.20.60 16 276 1.2E-59 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS07610 8342b4cafa5cf536757d076c2b14bd3c 328 PIRSF PIRSF015582 7 327 8.1E-63 T 17-03-2017 IPR011206 Citrate lyase beta subunit-like SHXM_RS07610 8342b4cafa5cf536757d076c2b14bd3c 328 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 20 265 2.8E-28 T 17-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 SHXM_RS07610 8342b4cafa5cf536757d076c2b14bd3c 328 SUPERFAMILY SSF51621 17 275 1.76E-47 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 Gene3D G3DSA:3.40.50.980 212 357 3.3E-52 T 17-03-2017 SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 Pfam PF13193 AMP-binding enzyme C-terminal domain 457 533 4.8E-19 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 Gene3D G3DSA:2.30.38.10 365 439 1.7E-28 T 17-03-2017 SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 ProSitePatterns PS00455 Putative AMP-binding domain signature. 197 208 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 Gene3D G3DSA:3.30.300.30 445 546 5.9E-33 T 17-03-2017 SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 Gene3D G3DSA:3.40.50.980 29 211 7.8E-40 T 17-03-2017 SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 Pfam PF00501 AMP-binding enzyme 36 448 5.7E-111 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS38920 4fcaf5377687ed69b9811f6ede8be9d8 574 SUPERFAMILY SSF56801 28 545 3.27E-160 T 17-03-2017 SHXM_RS38170 af7b66827c2d68d8ef58e4360c8fa1bf 478 Gene3D G3DSA:3.40.190.10 187 386 7.5E-35 T 17-03-2017 SHXM_RS38170 af7b66827c2d68d8ef58e4360c8fa1bf 478 SUPERFAMILY SSF53850 31 475 5.92E-58 T 17-03-2017 SHXM_RS38170 af7b66827c2d68d8ef58e4360c8fa1bf 478 Pfam PF13416 Bacterial extracellular solute-binding protein 83 388 2.8E-24 T 17-03-2017 SHXM_RS38170 af7b66827c2d68d8ef58e4360c8fa1bf 478 TIGRFAM TIGR03851 chitin_NgcE: carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein 25 475 2.5E-186 T 17-03-2017 IPR022386 Carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 128 140 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 Gene3D G3DSA:1.10.540.10 10 123 2.5E-32 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 Gene3D G3DSA:1.20.140.10 222 386 2.3E-68 T 17-03-2017 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 232 380 5.7E-46 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 SUPERFAMILY SSF56645 5 244 2.62E-74 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 339 358 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 11 122 2.0E-26 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 126 220 9.7E-26 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 Gene3D G3DSA:2.40.110.10 125 221 1.3E-39 T 17-03-2017 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 PIRSF PIRSF016578 5 388 7.6E-25 T 17-03-2017 SHXM_RS01140 f995fa4883e0f69b52cb21ed7ed7c5ac 401 SUPERFAMILY SSF47203 230 384 4.04E-55 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS43465 af77b310437a5b9ea5eed04499d8d8d6 170 TIGRFAM TIGR00072 hydrog_prot: hydrogenase maturation protease 6 147 8.9E-31 T 17-03-2017 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 SHXM_RS43465 af77b310437a5b9ea5eed04499d8d8d6 170 SUPERFAMILY SSF53163 4 151 2.56E-31 T 17-03-2017 IPR023430 Peptidase HybD-like domain SHXM_RS43465 af77b310437a5b9ea5eed04499d8d8d6 170 Pfam PF01750 Hydrogenase maturation protease 24 146 7.0E-11 T 17-03-2017 IPR000671 Peptidase A31 family GO:0008047|GO:0008233 SHXM_RS43465 af77b310437a5b9ea5eed04499d8d8d6 170 Gene3D G3DSA:3.40.50.1450 4 153 1.2E-33 T 17-03-2017 IPR023430 Peptidase HybD-like domain SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 SUPERFAMILY SSF46785 1 110 7.27E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 Pfam PF03466 LysR substrate binding domain 88 293 9.0E-34 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 Gene3D G3DSA:1.10.10.10 1 81 8.1E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 3.4E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 3.4E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 3.4E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 Gene3D G3DSA:3.40.190.10 177 262 2.3E-11 T 17-03-2017 SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 1.2E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 Gene3D G3DSA:3.40.190.10 88 176 1.7E-18 T 17-03-2017 SHXM_RS05875 7b23322c34badbf7dd4b67d7b1e5ecd2 309 SUPERFAMILY SSF53850 88 297 2.51E-35 T 17-03-2017 SHXM_RS19400 d3197a79dd8b8909d64c99a7baff9991 269 Pfam PF01061 ABC-2 type transporter 21 230 3.0E-31 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS19400 d3197a79dd8b8909d64c99a7baff9991 269 PIRSF PIRSF006648 6 269 1.0E-76 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS33295 83df31ffed7c9b8b5f0c736f1591177e 313 Gene3D G3DSA:1.10.3720.10 102 303 8.2E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33295 83df31ffed7c9b8b5f0c736f1591177e 313 SUPERFAMILY SSF161098 105 290 5.36E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33295 83df31ffed7c9b8b5f0c736f1591177e 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 126 301 1.4E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33295 83df31ffed7c9b8b5f0c736f1591177e 313 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 37 85 1.1E-5 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 Gene3D G3DSA:1.10.45.10 414 453 6.7E-16 T 17-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 Gene3D G3DSA:3.30.465.10 94 213 5.7E-42 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 SUPERFAMILY SSF56176 2 212 2.52E-69 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 SUPERFAMILY SSF55103 217 455 7.52E-58 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 Pfam PF02913 FAD linked oxidases, C-terminal domain 215 453 2.8E-59 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 Gene3D G3DSA:3.30.43.10 2 92 3.9E-21 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS05525 1e57763b2628aa1f86f85138e88a1ec7 457 Pfam PF01565 FAD binding domain 38 177 8.2E-42 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 Gene3D G3DSA:1.10.357.10 78 207 1.5E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 SUPERFAMILY SSF48498 81 203 3.74E-14 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 SUPERFAMILY SSF46689 9 73 7.98E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 Gene3D G3DSA:1.10.10.60 10 71 1.5E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 5.5E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 5.5E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 Pfam PF14246 AefR-like transcriptional repressor, C-terminal region 150 204 2.6E-16 T 17-03-2017 SHXM_RS39895 f55761d19c0bf1ede489db22ecee8806 212 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 66 1.9E-16 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 Gene3D G3DSA:3.40.50.10190 242 319 1.6E-12 T 17-03-2017 IPR001357 BRCT domain SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 TIGRFAM TIGR00573 dnaq: exonuclease, DNA polymerase III, epsilon subunit family 26 185 2.7E-25 T 17-03-2017 IPR006054 DNA polymerase III, epsilon subunit GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 SUPERFAMILY SSF53098 22 191 1.12E-41 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 SMART SM00479 25 189 2.1E-34 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 SUPERFAMILY SSF52113 239 318 9.94E-12 T 17-03-2017 IPR001357 BRCT domain SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 Gene3D G3DSA:3.30.420.10 23 189 1.0E-44 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS17405 bc9a0b662c99002dd4c552b56083585a 328 Pfam PF00929 Exonuclease 28 180 7.2E-21 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS08990 abcedcca8c736c9fd93973e8a2e4ed3b 394 SUPERFAMILY SSF53098 57 368 3.79E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS08990 abcedcca8c736c9fd93973e8a2e4ed3b 394 Pfam PF13546 DDE superfamily endonuclease 22 236 6.7E-53 T 17-03-2017 SHXM_RS23160 2efc54d122f5b2350bdc5941b7a7e724 349 Gene3D G3DSA:3.40.190.10 33 141 5.3E-7 T 17-03-2017 SHXM_RS23160 2efc54d122f5b2350bdc5941b7a7e724 349 Gene3D G3DSA:3.40.190.10 142 257 8.2E-15 T 17-03-2017 SHXM_RS23160 2efc54d122f5b2350bdc5941b7a7e724 349 SUPERFAMILY SSF53850 48 277 5.02E-36 T 17-03-2017 SHXM_RS23160 2efc54d122f5b2350bdc5941b7a7e724 349 Pfam PF09084 NMT1/THI5 like 57 272 7.8E-45 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 SUPERFAMILY SSF51735 6 226 1.53E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 Gene3D G3DSA:3.40.50.720 7 226 1.4E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 9.3E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 125 133 9.3E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 164 9.3E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 166 183 9.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 9.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 9.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 145 164 9.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 199 219 9.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 119 135 9.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02955 3663a72b80ce8ee99118147bf0e525a6 247 Pfam PF00106 short chain dehydrogenase 7 184 1.6E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS29255 3e17bb26cc99fe59199161e9b6221178 270 SUPERFAMILY SSF140959 14 269 5.62E-77 T 17-03-2017 SHXM_RS29255 3e17bb26cc99fe59199161e9b6221178 270 Pfam PF03301 Tryptophan 2,3-dioxygenase 199 270 2.4E-23 T 17-03-2017 IPR004981 Tryptophan 2,3-dioxygenase GO:0004833|GO:0019441|GO:0020037 KEGG: 00380+1.13.11.11|Reactome: R-HSA-71240 SHXM_RS29255 3e17bb26cc99fe59199161e9b6221178 270 Pfam PF03301 Tryptophan 2,3-dioxygenase 3 195 2.1E-46 T 17-03-2017 IPR004981 Tryptophan 2,3-dioxygenase GO:0004833|GO:0019441|GO:0020037 KEGG: 00380+1.13.11.11|Reactome: R-HSA-71240 SHXM_RS29255 3e17bb26cc99fe59199161e9b6221178 270 Hamap MF_01972 Tryptophan 2,3-dioxygenase [kynA]. 8 270 35.969 T 17-03-2017 IPR004981 Tryptophan 2,3-dioxygenase GO:0004833|GO:0019441|GO:0020037 KEGG: 00380+1.13.11.11|Reactome: R-HSA-71240 SHXM_RS02370 51a29490d34ba055f461f9a668ae9d2d 496 Gene3D G3DSA:3.40.605.10 21 280 1.4E-69 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS02370 51a29490d34ba055f461f9a668ae9d2d 496 Gene3D G3DSA:3.40.309.10 281 463 4.9E-55 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS02370 51a29490d34ba055f461f9a668ae9d2d 496 SUPERFAMILY SSF53720 19 490 1.57E-129 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS02370 51a29490d34ba055f461f9a668ae9d2d 496 Pfam PF00171 Aldehyde dehydrogenase family 27 485 1.6E-129 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS00840 05a4d9e5b851f7503c423bb7ccb57732 93 Gene3D G3DSA:3.40.50.270 2 82 3.2E-8 T 17-03-2017 SHXM_RS00840 05a4d9e5b851f7503c423bb7ccb57732 93 SUPERFAMILY SSF52794 1 86 6.28E-16 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS00840 05a4d9e5b851f7503c423bb7ccb57732 93 Pfam PF02302 PTS system, Lactose/Cellobiose specific IIB subunit 4 83 2.2E-11 T 17-03-2017 IPR003501 Phosphotransferase system, EIIB component, type 2/3 GO:0008982|GO:0009401 SHXM_RS09115 f0a49691f54cc9d1038c936eeeb85d09 254 Pfam PF13359 DDE superfamily endonuclease 103 247 1.9E-24 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS09115 f0a49691f54cc9d1038c936eeeb85d09 254 Gene3D G3DSA:1.10.260.40 51 73 8.9E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS09115 f0a49691f54cc9d1038c936eeeb85d09 254 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 43 85 4.5E-10 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS08230 c556b72d88e4eba64319365cecb87ff5 309 SUPERFAMILY SSF161098 91 292 6.21E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08230 c556b72d88e4eba64319365cecb87ff5 309 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 304 9.1E-34 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08230 c556b72d88e4eba64319365cecb87ff5 309 Gene3D G3DSA:1.10.3720.10 90 294 1.6E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Gene3D G3DSA:1.25.40.10 467 641 6.3E-20 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Gene3D G3DSA:3.40.50.300 62 170 8.2E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SUPERFAMILY SSF52540 38 312 3.06E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Pfam PF00931 NB-ARC domain 67 311 1.6E-6 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Pfam PF13424 Tetratricopeptide repeat 572 640 7.7E-9 T 17-03-2017 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Pfam PF13424 Tetratricopeptide repeat 654 721 9.0E-9 T 17-03-2017 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Pfam PF13424 Tetratricopeptide repeat 491 562 8.7E-8 T 17-03-2017 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SUPERFAMILY SSF48452 655 771 4.43E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SUPERFAMILY SSF48452 491 640 2.4E-23 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 Gene3D G3DSA:1.25.40.10 658 774 2.4E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SMART SM00028 571 604 5.1 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SMART SM00028 611 644 83.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SMART SM00028 531 564 1.8 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SMART SM00028 491 524 18.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SMART SM00028 731 764 80.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 SMART SM00028 691 724 76.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 PRINTS PR00364 Disease resistance protein signature 71 86 5.4E-11 T 17-03-2017 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 PRINTS PR00364 Disease resistance protein signature 157 171 5.4E-11 T 17-03-2017 SHXM_RS25625 5b7b6c182f6a212b7288514b0255efd5 800 PRINTS PR00364 Disease resistance protein signature 246 260 5.4E-11 T 17-03-2017 SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 SUPERFAMILY SSF52743 33 324 1.57E-81 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 TIGRFAM TIGR03921 T7SS_mycosin: type VII secretion-associated serine protease mycosin 40 381 9.8E-96 T 17-03-2017 IPR023834 Type VII secretion system peptidase S8A, mycosin-1 SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 Pfam PF00082 Subtilase family 51 314 8.2E-47 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 Gene3D G3DSA:3.40.50.200 29 325 5.1E-80 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 56 67 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 PRINTS PR00723 Subtilisin serine protease family (S8) signature 51 70 4.1E-15 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 PRINTS PR00723 Subtilisin serine protease family (S8) signature 263 279 4.1E-15 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS13170 c69db6c64c3a4d0e2c0108d1093c2f7c 405 PRINTS PR00723 Subtilisin serine protease family (S8) signature 91 104 4.1E-15 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS16605 681a9a2df26f91ce95ca355b33d1629b 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 71 2.1E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16605 681a9a2df26f91ce95ca355b33d1629b 196 SUPERFAMILY SSF48498 92 195 1.37E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS16605 681a9a2df26f91ce95ca355b33d1629b 196 SUPERFAMILY SSF46689 13 93 3.99E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16605 681a9a2df26f91ce95ca355b33d1629b 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 1.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16605 681a9a2df26f91ce95ca355b33d1629b 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 1.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16605 681a9a2df26f91ce95ca355b33d1629b 196 Gene3D G3DSA:1.10.357.10 14 194 3.1E-40 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS07935 37712de55bcda8deb9990748488642ef 83 Pfam PF05120 Gas vesicle protein G 7 72 1.7E-19 T 17-03-2017 IPR007804 Gas vesicle protein GvpG SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 Pfam PF13641 Glycosyltransferase like family 2 439 663 2.6E-28 T 17-03-2017 SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 Gene3D G3DSA:3.90.550.10 442 678 1.2E-18 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 Gene3D G3DSA:3.30.70.270 188 331 2.9E-8 T 17-03-2017 SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 Gene3D G3DSA:3.40.50.2300 60 177 9.7E-9 T 17-03-2017 SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 SUPERFAMILY SSF53448 442 681 1.41E-33 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 SUPERFAMILY SSF55073 191 324 6.36E-6 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS06295 90dfe674f18dc55c3c3ba2c21ac464d1 812 SUPERFAMILY SSF52172 62 185 1.36E-11 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 133 153 5.5E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 103 119 5.5E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 PRINTS PR00598 Bacterial regulatory protein MarR family signature 84 99 5.5E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 SMART SM00347 43 143 3.0E-15 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 SUPERFAMILY SSF46785 20 154 4.91E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 Pfam PF12802 MarR family 48 106 4.6E-11 T 17-03-2017 SHXM_RS20095 bf4b53529ce348b59607ef8929aa838f 159 Gene3D G3DSA:1.10.10.10 22 154 3.1E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 Pfam PF00698 Acyl transferase domain 38 300 6.3E-29 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 SUPERFAMILY SSF52151 11 143 3.14E-47 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 SUPERFAMILY SSF52151 209 311 3.14E-47 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 SUPERFAMILY SSF47336 414 505 3.53E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 14 313 2.3E-19 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 Gene3D G3DSA:3.30.70.250 144 195 7.8E-4 T 17-03-2017 SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 Pfam PF00550 Phosphopantetheine attachment site 421 488 1.0E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 ProSitePatterns PS00012 Phosphopantetheine attachment site. 447 462 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 Gene3D G3DSA:3.40.366.10 8 137 7.9E-48 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 Gene3D G3DSA:3.40.366.10 207 312 7.9E-48 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 SUPERFAMILY SSF55048 143 200 1.83E-6 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS13380 4b2aba72c66cdde270477334cd0945eb 507 Gene3D G3DSA:1.10.1200.10 416 496 1.5E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 SMART SM01134 88 249 1.4E-61 T 17-03-2017 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 Pfam PF08220 DeoR-like helix-turn-helix domain 22 75 5.0E-16 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 SMART SM00420 22 74 1.8E-15 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 Pfam PF00455 DeoR C terminal sensor domain 91 248 1.3E-42 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 SUPERFAMILY SSF100950 91 250 8.89E-28 T 17-03-2017 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 40 54 1.5E-8 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 54 72 1.5E-8 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 Gene3D G3DSA:3.40.50.1360 92 231 8.8E-12 T 17-03-2017 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 Gene3D G3DSA:1.10.10.10 17 71 2.4E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 ProSitePatterns PS00894 DeoR-type HTH domain signature. 22 56 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS07795 b3eb86c2857af459876a4771786ae9f6 269 SUPERFAMILY SSF46785 20 75 8.08E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 Pfam PF07690 Major Facilitator Superfamily 55 449 1.4E-46 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 Gene3D G3DSA:1.20.1250.20 493 518 8.8E-19 T 17-03-2017 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 Gene3D G3DSA:1.20.1250.20 52 233 1.3E-32 T 17-03-2017 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 Gene3D G3DSA:1.20.1250.20 302 459 8.8E-19 T 17-03-2017 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 SUPERFAMILY SSF103473 37 233 1.06E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 SUPERFAMILY SSF103473 492 520 1.06E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 SUPERFAMILY SSF103473 287 458 1.06E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 PRINTS PR01036 Tetracycline resistance protein TetB signature 144 164 9.7E-7 T 17-03-2017 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 PRINTS PR01036 Tetracycline resistance protein TetB signature 199 223 9.7E-7 T 17-03-2017 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 PRINTS PR01036 Tetracycline resistance protein TetB signature 174 198 9.7E-7 T 17-03-2017 SHXM_RS49935 daf834ba6f3425f39905667885eed66f 524 PRINTS PR01036 Tetracycline resistance protein TetB signature 54 78 9.7E-7 T 17-03-2017 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 Gene3D G3DSA:3.40.50.980 203 320 1.1E-27 T 17-03-2017 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 Gene3D G3DSA:2.30.38.10 334 408 3.3E-11 T 17-03-2017 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 Gene3D G3DSA:3.30.300.30 410 512 3.6E-30 T 17-03-2017 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 SUPERFAMILY SSF56801 5 514 4.45E-118 T 17-03-2017 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 Pfam PF00501 AMP-binding enzyme 8 414 1.2E-67 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 Pfam PF13193 AMP-binding enzyme C-terminal domain 423 501 1.8E-19 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 Gene3D G3DSA:3.40.50.980 7 174 2.9E-29 T 17-03-2017 SHXM_RS43580 7ca2b79a5c5d917f5a18bd788fdebcea 518 ProSitePatterns PS00455 Putative AMP-binding domain signature. 161 172 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 2.2E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 127 143 2.2E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 2.2E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 2.2E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 207 227 2.2E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 2.2E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 SUPERFAMILY SSF51735 4 243 3.06E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 185 0.0016 T 17-03-2017 SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 Gene3D G3DSA:3.40.50.720 1 243 1.4E-82 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 133 141 1.5E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 1.5E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 1.5E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32355 912cbe7ba0fa7a9c243f8228ba8a9c35 245 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 243 1.2E-63 T 17-03-2017 SHXM_RS08395 806dac52832241040ed00ef02b9473a1 412 SUPERFAMILY SSF53623 226 279 4.97E-30 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS08395 806dac52832241040ed00ef02b9473a1 412 SUPERFAMILY SSF53623 51 196 4.97E-30 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS08395 806dac52832241040ed00ef02b9473a1 412 Pfam PF08245 Mur ligase middle domain 65 266 5.3E-12 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS08395 806dac52832241040ed00ef02b9473a1 412 Gene3D G3DSA:3.40.1190.10 47 284 2.0E-38 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS08395 806dac52832241040ed00ef02b9473a1 412 Pfam PF08353 Domain of unknown function (DUF1727) 304 403 6.1E-21 T 17-03-2017 IPR013564 Domain of unknown function DUF1727 SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 Pfam PF12802 MarR family 42 94 1.5E-12 T 17-03-2017 SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 90 106 9.9E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 71 86 9.9E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 54 70 9.9E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 SUPERFAMILY SSF46785 13 141 3.29E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 SMART SM00347 30 130 1.7E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02505 7273fce89690de68e6c01e93e7ba6460 153 Gene3D G3DSA:1.10.10.10 8 141 1.8E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 Pfam PF16884 N-terminal domain of oxidoreductase 8 116 1.3E-20 T 17-03-2017 SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 Gene3D G3DSA:3.90.180.10 5 144 5.3E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 SUPERFAMILY SSF50129 6 126 1.39E-24 T 17-03-2017 IPR011032 GroES-like SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 SMART SM00829 18 336 6.1E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 SUPERFAMILY SSF51735 128 303 5.27E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 Pfam PF00107 Zinc-binding dehydrogenase 161 287 3.5E-19 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS24395 7baed54d8c2c9d64166e4db42a20552e 338 Gene3D G3DSA:3.40.50.720 145 306 6.4E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 ProSitePatterns PS00977 FAD-dependent glycerol-3-phosphate dehydrogenase signature 1. 28 45 - T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 SUPERFAMILY SSF51905 290 351 1.69E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 SUPERFAMILY SSF51905 24 253 1.69E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 Gene3D G3DSA:3.50.50.60 20 251 1.7E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 Pfam PF16901 C-terminal domain of alpha-glycerophosphate oxidase 404 528 4.7E-30 T 17-03-2017 IPR031656 Alpha-glycerophosphate oxidase, C-terminal KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 ProSitePatterns PS00978 FAD-dependent glycerol-3-phosphate dehydrogenase signature 2. 376 386 - T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 Pfam PF01266 FAD dependent oxidoreductase 24 377 1.4E-50 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 36 46 3.4E-31 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 341 347 3.4E-31 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 23 35 3.4E-31 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 98 110 3.4E-31 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 52 64 3.4E-31 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS31610 d6c09fe3ca128db9ae45588e1f14235a 568 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 371 383 3.4E-31 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS17765 372b1934529f2c8cc9d19d21ad8c90cc 335 Gene3D G3DSA:3.20.20.30 9 330 8.3E-80 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS17765 372b1934529f2c8cc9d19d21ad8c90cc 335 SUPERFAMILY SSF51679 10 330 1.96E-66 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS17765 372b1934529f2c8cc9d19d21ad8c90cc 335 TIGRFAM TIGR03558 oxido_grp_1: luciferase family oxidoreductase, group 1 10 330 2.0E-104 T 17-03-2017 IPR019949 Luciferase family oxidoreductase, group 1 SHXM_RS17765 372b1934529f2c8cc9d19d21ad8c90cc 335 Pfam PF00296 Luciferase-like monooxygenase 10 303 1.0E-39 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS38120 cc1fe9cbc4321217e95b256c353d2a28 293 Gene3D G3DSA:3.40.630.30 9 140 4.4E-17 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38120 cc1fe9cbc4321217e95b256c353d2a28 293 Pfam PF00583 Acetyltransferase (GNAT) family 65 135 8.9E-9 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS38120 cc1fe9cbc4321217e95b256c353d2a28 293 SUPERFAMILY SSF55729 9 140 3.04E-19 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS06215 a7d07daf445b5735214bdda3eaf47635 56 SUPERFAMILY SSF57829 1 38 3.3E-9 T 17-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 SHXM_RS06215 a7d07daf445b5735214bdda3eaf47635 56 Pfam PF01783 Ribosomal L32p protein family 2 46 3.5E-13 T 17-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS06215 a7d07daf445b5735214bdda3eaf47635 56 Hamap MF_00340 50S ribosomal protein L32 [rpmF]. 1 53 13.351 T 17-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS06215 a7d07daf445b5735214bdda3eaf47635 56 TIGRFAM TIGR01031 rpmF_bact: ribosomal protein bL32 2 43 4.8E-12 T 17-03-2017 IPR002677 Ribosomal protein L32p GO:0003735|GO:0006412|GO:0015934 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS16210 ae1b07529b0ac14f613bc4b972ca2a14 368 SUPERFAMILY SSF53756 20 362 7.63E-55 T 17-03-2017 SHXM_RS16210 ae1b07529b0ac14f613bc4b972ca2a14 368 Pfam PF00534 Glycosyl transferases group 1 180 338 1.5E-27 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS16210 ae1b07529b0ac14f613bc4b972ca2a14 368 Gene3D G3DSA:3.40.50.2000 178 338 2.1E-23 T 17-03-2017 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 PIRSF PIRSF005917 1 280 2.9E-89 T 17-03-2017 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 SUPERFAMILY SSF53790 3 222 8.77E-73 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 TIGRFAM TIGR00096 TIGR00096: 16S rRNA (cytidine(1402)-2'-O)-methyltransferase 6 272 1.0E-58 T 17-03-2017 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 4 207 1.8E-30 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 Gene3D G3DSA:3.30.950.10 114 225 4.3E-44 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 Gene3D G3DSA:3.40.1010.10 3 113 1.7E-7 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS32660 e839dcc75a2e420a1ee88786e572d3b4 291 Hamap MF_01877 Ribosomal RNA small subunit methyltransferase I [rsmI]. 4 224 32.391 T 17-03-2017 IPR008189 rRNA small subunit methyltransferase I GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS16560 95945549ec9cfacbb483a48faf5abe62 270 Pfam PF00535 Glycosyl transferase family 2 35 176 7.8E-22 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS16560 95945549ec9cfacbb483a48faf5abe62 270 SUPERFAMILY SSF53448 19 248 4.64E-40 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS16560 95945549ec9cfacbb483a48faf5abe62 270 Gene3D G3DSA:3.90.550.10 33 256 1.9E-17 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS04435 53d26ce3174be47fa8ce5b93aa2b7d6c 486 Pfam PF13556 PucR C-terminal helix-turn-helix domain 420 478 1.5E-18 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS04435 53d26ce3174be47fa8ce5b93aa2b7d6c 486 Pfam PF07905 Purine catabolism regulatory protein-like family 13 130 3.0E-28 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 Gene3D G3DSA:3.40.1410.10 92 264 1.3E-22 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 Pfam PF00392 Bacterial regulatory proteins, gntR family 35 95 1.1E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 SUPERFAMILY SSF64288 84 263 5.18E-26 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 SMART SM00866 117 258 1.9E-10 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 Pfam PF07702 UTRA domain 119 255 1.7E-14 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 SMART SM00345 38 95 3.7E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 Gene3D G3DSA:1.10.10.10 31 91 7.3E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49515 b784fb41f11dfbed20f78bf733009967 267 SUPERFAMILY SSF46785 30 98 5.77E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32905 bd475f59032ecd418b47813f07bd4c17 77 Pfam PF00741 Gas vesicle protein 24 60 1.5E-13 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS04100 5cace0fc027c8fce358c385b0c917f6e 71 SUPERFAMILY SSF54862 4 62 4.19E-8 T 17-03-2017 SHXM_RS04100 5cace0fc027c8fce358c385b0c917f6e 71 Gene3D G3DSA:3.30.70.20 3 65 1.5E-14 T 17-03-2017 SHXM_RS04100 5cace0fc027c8fce358c385b0c917f6e 71 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 7 59 2.0E-10 T 17-03-2017 SHXM_RS04100 5cace0fc027c8fce358c385b0c917f6e 71 PRINTS PR00352 3Fe-4S ferredoxin signature 46 58 3.5E-5 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS04100 5cace0fc027c8fce358c385b0c917f6e 71 PRINTS PR00352 3Fe-4S ferredoxin signature 18 28 3.5E-5 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS04100 5cace0fc027c8fce358c385b0c917f6e 71 PRINTS PR00352 3Fe-4S ferredoxin signature 7 18 3.5E-5 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS40075 df76493781e88ad0311adac9a95fe891 292 Pfam PF01255 Putative undecaprenyl diphosphate synthase 64 281 7.1E-69 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS40075 df76493781e88ad0311adac9a95fe891 292 SUPERFAMILY SSF64005 57 277 1.7E-72 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS40075 df76493781e88ad0311adac9a95fe891 292 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 58 281 3.2E-68 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS40075 df76493781e88ad0311adac9a95fe891 292 Gene3D G3DSA:3.40.1180.10 56 285 4.9E-82 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS40075 df76493781e88ad0311adac9a95fe891 292 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 227 244 - T 17-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 SHXM_RS40075 df76493781e88ad0311adac9a95fe891 292 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 57 282 36.37 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS06910 a93256300ec11a8fbafc025f329c6425 439 Pfam PF01547 Bacterial extracellular solute-binding protein 57 350 6.5E-47 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS06910 a93256300ec11a8fbafc025f329c6425 439 Gene3D G3DSA:3.40.190.10 159 369 1.8E-49 T 17-03-2017 SHXM_RS06910 a93256300ec11a8fbafc025f329c6425 439 SUPERFAMILY SSF53850 40 435 1.63E-70 T 17-03-2017 SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 SUPERFAMILY SSF46785 10 71 1.12E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 SMART SM00345 10 67 5.4E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 SUPERFAMILY SSF53383 111 479 5.36E-78 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 Pfam PF00155 Aminotransferase class I and II 128 460 1.2E-21 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 Gene3D G3DSA:3.40.640.10 151 366 2.9E-52 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 Gene3D G3DSA:1.10.10.10 11 71 4.3E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 Gene3D G3DSA:3.90.1150.10 370 475 2.2E-14 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS13040 5bbbe3063f85edbc89b0625fd33845fc 484 Pfam PF00392 Bacterial regulatory proteins, gntR family 13 66 6.1E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34250 8fc38f10873ce4cbaee692237507715e 392 Gene3D G3DSA:3.40.50.720 12 258 1.8E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34250 8fc38f10873ce4cbaee692237507715e 392 Pfam PF00899 ThiF family 21 254 1.9E-67 T 17-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SHXM_RS34250 8fc38f10873ce4cbaee692237507715e 392 Gene3D G3DSA:3.40.250.10 274 386 2.3E-28 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS34250 8fc38f10873ce4cbaee692237507715e 392 Pfam PF00581 Rhodanese-like domain 290 383 1.0E-13 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS34250 8fc38f10873ce4cbaee692237507715e 392 SMART SM00450 290 387 2.2E-23 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS34250 8fc38f10873ce4cbaee692237507715e 392 SUPERFAMILY SSF69572 7 357 4.71E-107 T 17-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SHXM_RS15540 5799d3e2dc0c3c230dd9a82de6b42efd 89 Pfam PF13358 DDE superfamily endonuclease 3 36 6.7E-9 T 17-03-2017 SHXM_RS48000 b59513a8b1f8aa8e4c1f43e4dd9194ce 177 Pfam PF13924 Lipocalin-like domain 37 174 4.4E-41 T 17-03-2017 IPR024311 Lipocalin-like domain SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 SUPERFAMILY SSF88659 125 190 3.05E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 Gene3D G3DSA:1.10.1740.10 16 120 1.2E-23 T 17-03-2017 SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 57 89 - T 17-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 SUPERFAMILY SSF88946 14 110 2.51E-23 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 Gene3D G3DSA:1.10.10.10 127 191 3.0E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 Pfam PF04542 Sigma-70 region 2 35 102 1.2E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 Pfam PF08281 Sigma-70, region 4 133 186 6.7E-13 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS14330 453d774208ecb4e2c5d10dad4c2769c1 194 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 31 189 1.4E-25 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36015 7879cedd0e64f1615b300240db657693 292 SUPERFAMILY SSF55961 8 150 1.71E-40 T 17-03-2017 SHXM_RS36015 7879cedd0e64f1615b300240db657693 292 SUPERFAMILY SSF55961 164 287 2.44E-16 T 17-03-2017 SHXM_RS36015 7879cedd0e64f1615b300240db657693 292 Gene3D G3DSA:3.30.530.20 5 155 1.9E-50 T 17-03-2017 IPR023393 START-like domain SHXM_RS36015 7879cedd0e64f1615b300240db657693 292 Gene3D G3DSA:3.30.530.20 163 287 2.2E-22 T 17-03-2017 IPR023393 START-like domain SHXM_RS36015 7879cedd0e64f1615b300240db657693 292 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 23 133 2.1E-22 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS36015 7879cedd0e64f1615b300240db657693 292 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 215 286 1.9E-7 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 Pfam PF13450 NAD(P)-binding Rossmann-like domain 13 46 6.8E-8 T 17-03-2017 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 Gene3D G3DSA:3.50.50.60 10 180 3.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 Gene3D G3DSA:3.50.50.60 282 359 3.4E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 SUPERFAMILY SSF51905 11 175 2.68E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 SUPERFAMILY SSF51905 282 361 2.68E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 296 311 1.5E-16 T 17-03-2017 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 10 32 1.5E-16 T 17-03-2017 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 154 169 1.5E-16 T 17-03-2017 SHXM_RS04805 f4227dd1ee2fceb5c0fa4ecff295acf2 381 Pfam PF01494 FAD binding domain 293 347 1.4E-6 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS19980 77fcbf2364728344407b633b3bd3a7f4 339 SUPERFAMILY SSF47090 263 332 4.71E-12 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS19980 77fcbf2364728344407b633b3bd3a7f4 339 Pfam PF01471 Putative peptidoglycan binding domain 274 330 8.2E-9 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS19980 77fcbf2364728344407b633b3bd3a7f4 339 Gene3D G3DSA:1.10.101.10 265 334 9.6E-15 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS46885 f010115a3f07733bf15680aa4e58c353 1049 SUPERFAMILY SSF49785 927 1041 9.92E-10 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46885 f010115a3f07733bf15680aa4e58c353 1049 Pfam PF00754 F5/8 type C domain 947 1034 2.5E-9 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS46885 f010115a3f07733bf15680aa4e58c353 1049 Pfam PF00754 F5/8 type C domain 643 722 2.7E-17 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS46885 f010115a3f07733bf15680aa4e58c353 1049 SUPERFAMILY SSF49785 639 727 3.4E-16 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46885 f010115a3f07733bf15680aa4e58c353 1049 Gene3D G3DSA:2.60.120.260 638 723 1.2E-18 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS46885 f010115a3f07733bf15680aa4e58c353 1049 Gene3D G3DSA:2.60.120.260 945 1037 1.0E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 Hamap MF_00572 2-isopropylmalate synthase [leuA]. 38 598 53.892 T 17-03-2017 IPR005668 2-isopropylmalate synthase GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 ProSitePatterns PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 70 86 - T 17-03-2017 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 TIGRFAM TIGR00970 leuA_yeast: 2-isopropylmalate synthase 37 598 7.4E-250 T 17-03-2017 IPR005668 2-isopropylmalate synthase GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 SUPERFAMILY SSF51569 52 362 5.86E-94 T 17-03-2017 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 Pfam PF08502 LeuA allosteric (dimerisation) domain 464 596 5.0E-35 T 17-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 Gene3D G3DSA:3.20.20.70 41 435 1.5E-142 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 SUPERFAMILY SSF89000 430 479 3.14E-15 T 17-03-2017 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 Pfam PF00682 HMGL-like 63 343 2.3E-73 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 SUPERFAMILY SSF110921 493 596 1.83E-35 T 17-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 ProSitePatterns PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 275 288 - T 17-03-2017 IPR002034 Alpha-isopropylmalate/homocitrate synthase, conserved site GO:0019752|GO:0046912 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS21210 1f5e008b47fea5683019522bf089995a 598 SMART SM00917 464 597 2.8E-38 T 17-03-2017 IPR013709 2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain GO:0003852|GO:0009098 KEGG: 00290+2.3.3.13|KEGG: 00620+2.3.3.13|MetaCyc: PWY-6871 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 Gene3D G3DSA:3.40.47.10 277 378 7.6E-7 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 PIRSF PIRSF000429 1 396 5.6E-39 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 SUPERFAMILY SSF53901 5 229 4.06E-36 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 SUPERFAMILY SSF53901 276 385 1.27E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 Pfam PF00108 Thiolase, N-terminal domain 6 111 4.3E-8 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 Gene3D G3DSA:3.40.47.10 17 112 5.7E-27 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43820 58b639a1ae07f81720d5b0c91288ff2b 396 Gene3D G3DSA:3.40.47.10 192 223 5.7E-27 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 Gene3D G3DSA:3.20.20.70 5 378 3.3E-97 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 SUPERFAMILY SSF51905 365 678 1.04E-26 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 SUPERFAMILY SSF51395 4 373 2.62E-88 T 17-03-2017 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 Gene3D G3DSA:3.50.50.60 478 625 6.7E-15 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 9 341 4.7E-47 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 Gene3D G3DSA:3.50.50.60 386 477 2.2E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 PRINTS PR00419 Adrenodoxin reductase family signature 412 425 6.2E-6 T 17-03-2017 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 PRINTS PR00419 Adrenodoxin reductase family signature 389 411 6.2E-6 T 17-03-2017 SHXM_RS47860 50ca7fa1a8a0602fa031468160cf5b05 681 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 389 614 5.0E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS02880 6f60400e3095153e4adebe0f738a67c7 346 PRINTS PR00069 Aldo-keto reductase signature 137 154 5.5E-10 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS02880 6f60400e3095153e4adebe0f738a67c7 346 PRINTS PR00069 Aldo-keto reductase signature 41 65 5.5E-10 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS02880 6f60400e3095153e4adebe0f738a67c7 346 PRINTS PR00069 Aldo-keto reductase signature 106 124 5.5E-10 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS02880 6f60400e3095153e4adebe0f738a67c7 346 SUPERFAMILY SSF51430 2 311 5.24E-100 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS02880 6f60400e3095153e4adebe0f738a67c7 346 Pfam PF00248 Aldo/keto reductase family 17 310 5.4E-74 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS02880 6f60400e3095153e4adebe0f738a67c7 346 Gene3D G3DSA:3.20.20.100 2 310 2.4E-97 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS41565 700af84743670a26aed24ba07c670807 463 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 137 149 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS41565 700af84743670a26aed24ba07c670807 463 SUPERFAMILY SSF56112 6 275 9.85E-75 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS41565 700af84743670a26aed24ba07c670807 463 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 18 41 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS41565 700af84743670a26aed24ba07c670807 463 Gene3D G3DSA:3.30.200.20 5 98 1.3E-26 T 17-03-2017 SHXM_RS41565 700af84743670a26aed24ba07c670807 463 SMART SM00220 12 277 2.3E-69 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS41565 700af84743670a26aed24ba07c670807 463 Pfam PF00069 Protein kinase domain 12 270 3.9E-46 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS41565 700af84743670a26aed24ba07c670807 463 Gene3D G3DSA:1.10.510.10 105 284 3.3E-45 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 Gene3D G3DSA:3.50.50.60 2 72 1.1E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 Gene3D G3DSA:3.50.50.60 118 196 1.1E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 Gene3D G3DSA:3.50.50.60 279 361 1.1E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 170 185 1.2E-42 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 342 358 1.2E-42 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 291 306 1.2E-42 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 306 322 1.2E-42 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 324 342 1.2E-42 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 1.2E-42 T 17-03-2017 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 SUPERFAMILY SSF51905 3 191 1.99E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 SUPERFAMILY SSF51905 278 367 1.99E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41420 0bc71c25bdf1676a585758f1f4ca65c8 506 Pfam PF01494 FAD binding domain 3 357 1.3E-61 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS25250 509c39641424bc3b0e2cf8e2e3a8c16d 362 SUPERFAMILY SSF47413 17 78 2.96E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS25250 509c39641424bc3b0e2cf8e2e3a8c16d 362 SMART SM00530 21 76 1.2E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS25250 509c39641424bc3b0e2cf8e2e3a8c16d 362 Pfam PF13560 Helix-turn-helix domain 18 76 1.8E-12 T 17-03-2017 SHXM_RS25250 509c39641424bc3b0e2cf8e2e3a8c16d 362 Pfam PF10901 Protein of unknown function (DUF2690) 252 345 1.1E-18 T 17-03-2017 IPR021224 Protein of unknown function DUF2690 SHXM_RS25250 509c39641424bc3b0e2cf8e2e3a8c16d 362 Gene3D G3DSA:1.10.260.40 21 76 3.0E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20090 c96132379e5f53bccfbf774314aa33ef 216 SUPERFAMILY SSF52218 1 211 1.34E-36 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS20090 c96132379e5f53bccfbf774314aa33ef 216 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 2 211 25.966 T 17-03-2017 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SHXM_RS20090 c96132379e5f53bccfbf774314aa33ef 216 Gene3D G3DSA:3.40.50.360 1 213 3.6E-55 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS20090 c96132379e5f53bccfbf774314aa33ef 216 Pfam PF02525 Flavodoxin-like fold 4 162 1.1E-32 T 17-03-2017 IPR003680 Flavodoxin-like fold SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 SUPERFAMILY SSF50129 3 186 2.13E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 SUPERFAMILY SSF51735 154 326 2.39E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 TIGRFAM TIGR03451 mycoS_dep_FDH: S-(hydroxymethyl)mycothiol dehydrogenase 5 361 3.3E-206 T 17-03-2017 IPR017816 S-(hydroxymethyl)mycothiol dehydrogenase KEGG: 00072+1.1.1.30|KEGG: 00650+1.1.1.30 SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 Pfam PF00107 Zinc-binding dehydrogenase 190 319 1.4E-29 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 Gene3D G3DSA:3.40.50.720 183 302 3.9E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 62 76 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 29 148 8.1E-27 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 Gene3D G3DSA:3.90.180.10 2 182 3.4E-55 T 17-03-2017 IPR011032 GroES-like SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 SMART SM00829 14 359 3.7E-5 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS25950 a3d799f3bb0d7fb7d12ba1cf14fc773c 361 SUPERFAMILY SSF50129 310 361 1.25E-8 T 17-03-2017 IPR011032 GroES-like SHXM_RS26745 633b91850da289f811918c5c9de48663 256 Pfam PF13384 Homeodomain-like domain 13 37 2.5E-6 T 17-03-2017 SHXM_RS26745 633b91850da289f811918c5c9de48663 256 Gene3D G3DSA:1.10.260.40 4 64 2.4E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26745 633b91850da289f811918c5c9de48663 256 SUPERFAMILY SSF47413 4 63 8.44E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10170 f66b359dadc6cfa114e591c8e29d82bf 1044 Pfam PF01526 Tn3 transposase DDE domain 617 1013 5.7E-131 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS10170 f66b359dadc6cfa114e591c8e29d82bf 1044 Pfam PF13700 Domain of unknown function (DUF4158) 5 174 4.0E-53 T 17-03-2017 IPR025296 Domain of unknown function DUF4158 SHXM_RS32430 110590b144b75c25bd38c95556f58627 300 Pfam PF00483 Nucleotidyl transferase 10 274 1.2E-26 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS32430 110590b144b75c25bd38c95556f58627 300 Gene3D G3DSA:3.90.550.10 10 282 2.7E-73 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS32430 110590b144b75c25bd38c95556f58627 300 SUPERFAMILY SSF53448 6 277 1.58E-62 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS32430 110590b144b75c25bd38c95556f58627 300 TIGRFAM TIGR01099 galU: UTP--glucose-1-phosphate uridylyltransferase 8 273 4.8E-102 T 17-03-2017 IPR005771 UTP--glucose-1-phosphate uridylyltransferase, bacterial/archaeal-type GO:0003983|GO:0006011 KEGG: 00040+2.7.7.9|KEGG: 00052+2.7.7.9|KEGG: 00500+2.7.7.9|KEGG: 00520+2.7.7.9|MetaCyc: PWY-3801|MetaCyc: PWY-6527|MetaCyc: PWY-7238|MetaCyc: PWY-7343 SHXM_RS09705 2e22364f22943484621805f7503968ea 411 SUPERFAMILY SSF48264 16 394 3.54E-53 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09705 2e22364f22943484621805f7503968ea 411 PRINTS PR00359 B-class P450 signature 98 109 1.5E-15 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09705 2e22364f22943484621805f7503968ea 411 PRINTS PR00359 B-class P450 signature 291 318 1.5E-15 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09705 2e22364f22943484621805f7503968ea 411 PRINTS PR00359 B-class P450 signature 144 160 1.5E-15 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09705 2e22364f22943484621805f7503968ea 411 PRINTS PR00359 B-class P450 signature 195 217 1.5E-15 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09705 2e22364f22943484621805f7503968ea 411 Gene3D G3DSA:1.10.630.10 11 395 2.5E-71 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS01805 228cbe6faa78130bc4b9f7d1bb74108b 460 Gene3D G3DSA:3.40.190.10 183 352 1.3E-16 T 17-03-2017 SHXM_RS01805 228cbe6faa78130bc4b9f7d1bb74108b 460 Gene3D G3DSA:3.40.190.10 353 385 4.1E-32 T 17-03-2017 SHXM_RS01805 228cbe6faa78130bc4b9f7d1bb74108b 460 Gene3D G3DSA:3.40.190.10 60 182 4.1E-32 T 17-03-2017 SHXM_RS01805 228cbe6faa78130bc4b9f7d1bb74108b 460 SUPERFAMILY SSF53850 61 459 1.04E-57 T 17-03-2017 SHXM_RS01805 228cbe6faa78130bc4b9f7d1bb74108b 460 Pfam PF01547 Bacterial extracellular solute-binding protein 79 365 4.3E-30 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS39870 d316b853298cccd15410ac0629432891 360 Pfam PF01546 Peptidase family M20/M25/M40 61 356 2.5E-22 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS39870 d316b853298cccd15410ac0629432891 360 Pfam PF07687 Peptidase dimerisation domain 158 256 1.6E-18 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS39870 d316b853298cccd15410ac0629432891 360 Gene3D G3DSA:3.40.630.10 1 170 9.7E-34 T 17-03-2017 SHXM_RS39870 d316b853298cccd15410ac0629432891 360 Gene3D G3DSA:3.40.630.10 301 358 9.7E-34 T 17-03-2017 SHXM_RS39870 d316b853298cccd15410ac0629432891 360 Gene3D G3DSA:3.30.70.360 171 257 6.1E-25 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS39870 d316b853298cccd15410ac0629432891 360 PIRSF PIRSF037238 1 360 2.1E-116 T 17-03-2017 IPR017150 Peptidase M20, glutamate carboxypeptidase SHXM_RS39870 d316b853298cccd15410ac0629432891 360 SUPERFAMILY SSF55031 161 272 7.07E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS39870 d316b853298cccd15410ac0629432891 360 SUPERFAMILY SSF53187 1 170 1.57E-36 T 17-03-2017 SHXM_RS39870 d316b853298cccd15410ac0629432891 360 SUPERFAMILY SSF53187 284 356 1.57E-36 T 17-03-2017 SHXM_RS45610 ebcc9df25094aaa293b828093af30102 187 SUPERFAMILY SSF160904 5 177 1.03E-43 T 17-03-2017 SHXM_RS45610 ebcc9df25094aaa293b828093af30102 187 Pfam PF11706 CGNR zinc finger 136 178 5.2E-18 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS45610 ebcc9df25094aaa293b828093af30102 187 Pfam PF07336 Putative stress-induced transcription regulator 10 131 8.8E-24 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS45610 ebcc9df25094aaa293b828093af30102 187 Gene3D G3DSA:1.10.3300.10 5 180 4.3E-47 T 17-03-2017 IPR023286 ABATE domain SHXM_RS34030 2854221b04ebe1bc8759d023ec8dc638 338 SUPERFAMILY SSF55729 235 331 1.01E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS34030 2854221b04ebe1bc8759d023ec8dc638 338 Pfam PF00583 Acetyltransferase (GNAT) family 266 322 5.9E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS34030 2854221b04ebe1bc8759d023ec8dc638 338 Gene3D G3DSA:3.40.630.30 225 334 4.0E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS29960 25ce3e8028de7142c316c5671c4ed54c 373 Gene3D G3DSA:3.40.190.10 53 208 1.4E-44 T 17-03-2017 SHXM_RS29960 25ce3e8028de7142c316c5671c4ed54c 373 Gene3D G3DSA:3.40.190.10 234 370 1.8E-19 T 17-03-2017 SHXM_RS29960 25ce3e8028de7142c316c5671c4ed54c 373 Pfam PF12849 PBP superfamily domain 52 343 2.5E-57 T 17-03-2017 IPR024370 PBP domain SHXM_RS29960 25ce3e8028de7142c316c5671c4ed54c 373 PIRSF PIRSF002756 10 373 4.5E-117 T 17-03-2017 IPR005673 ABC transporter, phosphate-binding protein PstS GO:0035435|GO:0042301|GO:0043190 SHXM_RS29960 25ce3e8028de7142c316c5671c4ed54c 373 SUPERFAMILY SSF53850 55 373 9.15E-86 T 17-03-2017 SHXM_RS29960 25ce3e8028de7142c316c5671c4ed54c 373 TIGRFAM TIGR00975 3a0107s03: phosphate ABC transporter, phosphate-binding protein PstS 57 371 2.7E-82 T 17-03-2017 IPR005673 ABC transporter, phosphate-binding protein PstS GO:0035435|GO:0042301|GO:0043190 SHXM_RS39245 073ff3682746d8127c201c23401f07ce 143 Pfam PF00011 Hsp20/alpha crystallin family 35 132 2.1E-20 T 17-03-2017 IPR002068 Alpha crystallin/Hsp20 domain SHXM_RS39245 073ff3682746d8127c201c23401f07ce 143 SUPERFAMILY SSF49764 16 134 1.01E-30 T 17-03-2017 IPR008978 HSP20-like chaperone SHXM_RS39245 073ff3682746d8127c201c23401f07ce 143 Gene3D G3DSA:2.60.40.790 6 134 1.2E-31 T 17-03-2017 IPR008978 HSP20-like chaperone SHXM_RS39645 4aeae6ada2f87602043443e5e1f969ac 386 SUPERFAMILY SSF53383 9 383 2.48E-94 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS39645 4aeae6ada2f87602043443e5e1f969ac 386 Gene3D G3DSA:3.40.640.10 12 247 2.0E-69 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS39645 4aeae6ada2f87602043443e5e1f969ac 386 Gene3D G3DSA:3.90.1150.10 249 385 1.1E-51 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS39645 4aeae6ada2f87602043443e5e1f969ac 386 PIRSF PIRSF000390 4 384 3.7E-106 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS39645 4aeae6ada2f87602043443e5e1f969ac 386 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 20 371 3.2E-111 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 SUPERFAMILY SSF46767 128 210 2.09E-26 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 Gene3D G3DSA:1.10.10.10 128 210 4.4E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 ProSitePatterns PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 179 185 - T 17-03-2017 IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site GO:0003908|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 TIGRFAM TIGR00589 ogt: methylated-DNA--[protein]-cysteine S-methyltransferase 128 208 3.8E-29 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 Hamap MF_00772 Methylated-DNA--protein-cysteine methyltransferase [ogt]. 24 211 34.985 T 17-03-2017 IPR023546 Methylated-DNA--protein-cysteine methyltransferase GO:0003824|GO:0006281 SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 130 210 1.1E-28 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 Gene3D G3DSA:3.30.160.70 25 67 2.0E-4 T 17-03-2017 SHXM_RS18015 4e52f2cb2b4df80bf595f7b705446fc7 216 SUPERFAMILY SSF53155 26 127 6.28E-9 T 17-03-2017 IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain GO:0003908|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS13300 f5421ce55085983f0f32652a5c6e84e5 468 Pfam PF00202 Aminotransferase class-III 48 442 1.5E-88 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS13300 f5421ce55085983f0f32652a5c6e84e5 468 Gene3D G3DSA:3.90.1150.10 30 82 1.9E-33 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS13300 f5421ce55085983f0f32652a5c6e84e5 468 Gene3D G3DSA:3.90.1150.10 330 444 1.9E-33 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS13300 f5421ce55085983f0f32652a5c6e84e5 468 Gene3D G3DSA:3.40.640.10 83 329 5.1E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS13300 f5421ce55085983f0f32652a5c6e84e5 468 SUPERFAMILY SSF53383 45 444 3.48E-107 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS13300 f5421ce55085983f0f32652a5c6e84e5 468 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 240 278 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SUPERFAMILY SSF51126 18 114 3.37E-35 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SUPERFAMILY SSF51126 275 299 3.37E-35 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SUPERFAMILY SSF51126 349 623 3.37E-35 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SMART SM00606 768 893 4.4E-14 T 17-03-2017 IPR006584 Cellulose binding, type IV GO:0030246 SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Gene3D G3DSA:2.60.120.260 645 765 1.1E-21 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SUPERFAMILY SSF49785 768 892 1.7E-17 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Pfam PF13229 Right handed beta helix region 350 517 1.3E-12 T 17-03-2017 SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Gene3D G3DSA:2.60.120.260 789 892 1.9E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SMART SM00710 356 377 6600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SMART SM00710 490 520 3800.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SMART SM00710 465 488 720.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SMART SM00710 285 313 1300.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SMART SM00710 378 405 18.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Pfam PF03422 Carbohydrate binding module (family 6) 796 892 4.2E-17 T 17-03-2017 IPR005084 Carbohydrate binding module family 6 GO:0030246 SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 SUPERFAMILY SSF49785 649 765 2.62E-20 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Gene3D G3DSA:2.160.20.10 211 546 5.7E-53 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Gene3D G3DSA:2.160.20.10 53 124 5.7E-53 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS03255 19532f72f1ec4fcbb46fcb681413858c 895 Pfam PF00754 F5/8 type C domain 651 758 1.5E-14 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 ProSitePatterns PS00217 Sugar transport proteins signature 2. 148 173 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 Pfam PF07690 Major Facilitator Superfamily 45 296 5.2E-26 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 Pfam PF07690 Major Facilitator Superfamily 305 452 8.6E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 Gene3D G3DSA:1.20.1250.20 264 453 2.5E-19 T 17-03-2017 SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 Gene3D G3DSA:1.20.1250.20 37 244 3.9E-23 T 17-03-2017 SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 ProSitePatterns PS00216 Sugar transport proteins signature 1. 323 340 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS41325 12e6ace8ccf7e3923166fd9bd50ab341 458 SUPERFAMILY SSF103473 25 455 1.14E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS25355 e5a3616ff183b24a8db942111d2200c6 261 Pfam PF03734 L,D-transpeptidase catalytic domain 145 254 1.3E-12 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS25355 e5a3616ff183b24a8db942111d2200c6 261 SUPERFAMILY SSF141523 144 255 6.02E-20 T 17-03-2017 SHXM_RS25355 e5a3616ff183b24a8db942111d2200c6 261 Gene3D G3DSA:2.40.440.10 148 255 2.7E-11 T 17-03-2017 SHXM_RS47515 41ee69af7062e53c1d10088719ed4a06 221 Gene3D G3DSA:3.40.50.720 1 218 2.3E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47515 41ee69af7062e53c1d10088719ed4a06 221 Pfam PF13460 NAD(P)H-binding 7 152 2.4E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47515 41ee69af7062e53c1d10088719ed4a06 221 SUPERFAMILY SSF51735 1 209 1.79E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02845 9e166d37e220f8a3c774432f374e01d8 224 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 15 198 1.3E-39 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS02845 9e166d37e220f8a3c774432f374e01d8 224 SUPERFAMILY SSF53639 7 221 4.32E-49 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS02845 9e166d37e220f8a3c774432f374e01d8 224 SMART SM01007 14 199 1.7E-45 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS02845 9e166d37e220f8a3c774432f374e01d8 224 Gene3D G3DSA:3.40.225.10 10 221 2.6E-61 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS50055 e98d749591c241d9e7f2fcc13f8e5e4b 321 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 311 1.8E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50055 e98d749591c241d9e7f2fcc13f8e5e4b 321 SUPERFAMILY SSF161098 82 309 2.09E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50055 e98d749591c241d9e7f2fcc13f8e5e4b 321 Gene3D G3DSA:1.10.3720.10 88 317 1.0E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27825 a9405756512e4d496a5fb7764be2c11d 384 SUPERFAMILY SSF56601 42 372 1.76E-71 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS27825 a9405756512e4d496a5fb7764be2c11d 384 Gene3D G3DSA:3.40.710.10 60 379 5.2E-73 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS27825 a9405756512e4d496a5fb7764be2c11d 384 Pfam PF00144 Beta-lactamase 59 361 6.4E-54 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Pfam PF01568 Molydopterin dinucleotide binding domain 613 728 2.2E-22 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Pfam PF00384 Molybdopterin oxidoreductase 58 433 3.6E-31 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Gene3D G3DSA:3.40.50.740 60 131 2.4E-44 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Gene3D G3DSA:3.40.50.740 320 435 2.4E-44 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Gene3D G3DSA:3.40.50.740 513 589 2.4E-44 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Pfam PF04879 Molybdopterin oxidoreductase Fe4S4 domain 7 51 2.5E-9 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Gene3D G3DSA:2.20.25.90 6 59 9.7E-15 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 SUPERFAMILY SSF53706 4 480 7.72E-114 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 SMART SM00926 1 55 9.4E-13 T 17-03-2017 IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domain GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Gene3D G3DSA:3.40.228.10 144 319 5.3E-50 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 Gene3D G3DSA:2.40.40.20 613 738 4.7E-27 T 17-03-2017 SHXM_RS16500 4797703b38d3008ee931a1410a0dc97e 742 SUPERFAMILY SSF50692 612 738 5.2E-30 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 SUPERFAMILY SSF53850 90 304 9.53E-34 T 17-03-2017 SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 SUPERFAMILY SSF46785 1 111 1.69E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 62 1.4E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 Pfam PF03466 LysR substrate binding domain 89 288 8.8E-35 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 Gene3D G3DSA:3.40.190.10 182 274 1.5E-23 T 17-03-2017 SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 Gene3D G3DSA:1.10.10.10 4 87 1.7E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48660 7bad802cd634a58162d2d227a0e61e3f 317 Gene3D G3DSA:3.40.190.10 90 181 2.2E-21 T 17-03-2017 SHXM_RS20260 e35359f1240e6231a8adcc834167f5ac 337 Pfam PF14472 Domain of unknown function (DUF4429) 139 274 3.9E-42 T 17-03-2017 IPR027860 Domain of unknown function DUF4429 SHXM_RS20260 e35359f1240e6231a8adcc834167f5ac 337 Pfam PF14472 Domain of unknown function (DUF4429) 12 106 2.9E-16 T 17-03-2017 IPR027860 Domain of unknown function DUF4429 SHXM_RS20260 e35359f1240e6231a8adcc834167f5ac 337 Pfam PF09851 Short C-terminal domain 307 334 6.3E-7 T 17-03-2017 IPR018649 SHOCT domain SHXM_RS09265 8349563059de5bc0ca84a3791eb8c3ff 141 Pfam PF13683 Integrase core domain 34 98 5.0E-13 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS09265 8349563059de5bc0ca84a3791eb8c3ff 141 SUPERFAMILY SSF53098 7 100 2.73E-14 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09265 8349563059de5bc0ca84a3791eb8c3ff 141 Gene3D G3DSA:3.30.420.10 8 98 2.2E-12 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS23150 c84e98f647e929ffe984eed06e2fcc5f 260 SUPERFAMILY SSF51679 3 218 1.47E-43 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS23150 c84e98f647e929ffe984eed06e2fcc5f 260 TIGRFAM TIGR03856 F420_MSMEG_2906: probable F420-dependent oxidoreductase, MSMEG_2906 family 3 255 7.3E-84 T 17-03-2017 IPR022480 F420-dependent oxidoreductase, MSMEG2906 SHXM_RS23150 c84e98f647e929ffe984eed06e2fcc5f 260 Gene3D G3DSA:3.20.20.30 3 217 3.1E-46 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS23150 c84e98f647e929ffe984eed06e2fcc5f 260 Pfam PF00296 Luciferase-like monooxygenase 8 216 6.9E-30 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS17115 a45ac068cb9ac5262b26d20715c4035e 390 Pfam PF16483 Beta-1,3-glucanase 40 387 4.2E-99 T 17-03-2017 IPR032477 Beta-1,3-glucanase, N-terminal KEGG: 00500+3.2.1.39 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 Gene3D G3DSA:3.40.309.10 276 465 3.6E-68 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 Gene3D G3DSA:3.40.605.10 16 275 2.3E-89 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 289 300 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 Pfam PF00171 Aldehyde dehydrogenase family 25 487 3.7E-165 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 SUPERFAMILY SSF53720 16 493 1.15E-161 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 261 268 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS40660 31bf46e20fecd970a871d65e3ab126ae 494 TIGRFAM TIGR03216 OH_muco_semi_DH: 2-hydroxymuconic semialdehyde dehydrogenase 16 494 2.3E-239 T 17-03-2017 IPR017628 2-hydroxymuconic semialdehyde dehydrogenase GO:0016620|GO:0055114 SHXM_RS32025 19b2681dffa63e4a2e34cb679cbac5b3 157 Pfam PF13279 Thioesterase-like superfamily 12 133 2.7E-21 T 17-03-2017 SHXM_RS32025 19b2681dffa63e4a2e34cb679cbac5b3 157 Gene3D G3DSA:3.10.129.10 5 139 8.4E-52 T 17-03-2017 IPR029069 HotDog domain SHXM_RS32025 19b2681dffa63e4a2e34cb679cbac5b3 157 SUPERFAMILY SSF54637 8 150 9.35E-39 T 17-03-2017 IPR029069 HotDog domain SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Pfam PF02368 Bacterial Ig-like domain (group 2) 709 741 7.2E-5 T 17-03-2017 IPR003343 Bacterial Ig-like, group 2 SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SMART SM00776 766 911 7.5E-69 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SUPERFAMILY SSF49373 686 757 3.37E-10 T 17-03-2017 IPR008964 Invasin/intimin cell-adhesion fragments SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SUPERFAMILY SSF49785 769 910 3.27E-42 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Pfam PF13229 Right handed beta helix region 499 632 4.9E-7 T 17-03-2017 SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Pfam PF08305 NPCBM/NEW2 domain 769 910 7.2E-51 T 17-03-2017 IPR013222 Glycosyl hydrolase family 98, putative carbohydrate-binding module SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Gene3D G3DSA:2.60.40.1080 709 757 1.9E-9 T 17-03-2017 SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Gene3D G3DSA:2.160.20.10 491 679 1.9E-31 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Gene3D G3DSA:2.160.20.10 247 393 1.9E-31 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 Gene3D G3DSA:2.160.20.10 41 163 1.9E-31 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SUPERFAMILY SSF51126 294 390 3.84E-40 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SUPERFAMILY SSF51126 483 621 3.84E-40 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SUPERFAMILY SSF51126 67 210 3.84E-40 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SUPERFAMILY SSF51126 30 40 3.84E-40 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SMART SM00710 553 574 2900.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SMART SM00710 370 392 200.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SMART SM00710 610 630 920.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SMART SM00710 497 519 400.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20525 b37dcc3fdb58281aa15db0d2500163f5 911 SMART SM00710 520 542 1800.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS16730 04dc5e98106de014a7de0591de1953e9 262 SUPERFAMILY SSF53901 24 261 9.67E-74 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16730 04dc5e98106de014a7de0591de1953e9 262 Gene3D G3DSA:3.40.47.10 19 262 2.4E-87 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16730 04dc5e98106de014a7de0591de1953e9 262 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 23 261 3.9E-82 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS16730 04dc5e98106de014a7de0591de1953e9 262 SMART SM00825 Beta-ketoacyl synthase 24 262 2.3E-33 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS37890 b5dab2ba23d041aa15ccac97ff9befa8 425 SUPERFAMILY SSF53756 27 419 5.61E-77 T 17-03-2017 SHXM_RS37890 b5dab2ba23d041aa15ccac97ff9befa8 425 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 31 420 1.4E-109 T 17-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SHXM_RS37890 b5dab2ba23d041aa15ccac97ff9befa8 425 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 244 389 1.4E-18 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS37890 b5dab2ba23d041aa15ccac97ff9befa8 425 Gene3D G3DSA:3.40.50.2000 255 401 1.5E-31 T 17-03-2017 SHXM_RS37890 b5dab2ba23d041aa15ccac97ff9befa8 425 Gene3D G3DSA:3.40.50.2000 27 254 3.2E-16 T 17-03-2017 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SMART SM00331 462 689 6.3E-25 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Pfam PF13581 Histidine kinase-like ATPase domain 704 807 3.2E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Pfam PF01590 GAF domain 364 431 1.1E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SUPERFAMILY SSF55785 11 118 5.58E-14 T 17-03-2017 IPR000014 PAS domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SUPERFAMILY SSF81606 475 688 9.42E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 19 104 1.5E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Pfam PF00989 PAS fold 19 118 5.7E-9 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Gene3D G3DSA:3.30.450.20 12 118 6.6E-13 T 17-03-2017 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SUPERFAMILY SSF55781 346 435 2.18E-10 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Gene3D G3DSA:3.30.450.40 257 439 5.6E-29 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SUPERFAMILY SSF55874 734 811 8.03E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Gene3D G3DSA:3.30.450.20 127 246 6.5E-14 T 17-03-2017 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SMART SM00091 129 196 3.8 T 17-03-2017 IPR000014 PAS domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SMART SM00091 9 76 0.093 T 17-03-2017 IPR000014 PAS domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 SUPERFAMILY SSF55785 127 242 4.89E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 489 689 2.5E-45 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS09255 4602fb1296531a2c02b7c5be1896b902 829 Pfam PF08448 PAS fold 138 246 7.0E-16 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS40935 8ceb0dc299b649ea196ad41ea8ef0f54 180 Gene3D G3DSA:3.40.50.150 28 161 9.0E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40935 8ceb0dc299b649ea196ad41ea8ef0f54 180 SUPERFAMILY SSF53335 26 169 1.06E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40935 8ceb0dc299b649ea196ad41ea8ef0f54 180 Pfam PF13649 Methyltransferase domain 37 127 1.2E-16 T 17-03-2017 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Gene3D G3DSA:3.40.47.10 36 296 7.8E-82 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1065 1239 8.3E-11 T 17-03-2017 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Gene3D G3DSA:3.40.50.720 1066 1262 6.4E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 413 529 8.5E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Pfam PF00698 Acyl transferase domain 622 671 1.6E-7 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Gene3D G3DSA:3.40.366.10 565 671 2.3E-20 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Pfam PF08990 Erythronolide synthase docking 2 27 3.7E-14 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SMART SM00825 Beta-ketoacyl synthase 36 462 2.6E-195 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 576 832 3.1E-7 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SUPERFAMILY SSF51735 1065 1296 1.08E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 292 409 3.8E-42 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Gene3D G3DSA:3.40.47.10 297 463 1.4E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SUPERFAMILY SSF52151 572 671 1.05E-21 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Pfam PF08659 KR domain 1065 1237 4.6E-28 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SUPERFAMILY SSF53901 33 399 1.08E-95 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 34 284 9.2E-81 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06415 5941518ed56796a275d20055731f3c09 1316 SUPERFAMILY SSF51735 831 1050 5.9E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02275 6797990cd8165dd1b308d304873c556f 462 SUPERFAMILY SSF103473 52 445 2.75E-62 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS02275 6797990cd8165dd1b308d304873c556f 462 Gene3D G3DSA:1.20.1250.20 266 444 3.1E-14 T 17-03-2017 SHXM_RS02275 6797990cd8165dd1b308d304873c556f 462 Pfam PF07690 Major Facilitator Superfamily 79 415 8.7E-41 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS02275 6797990cd8165dd1b308d304873c556f 462 Gene3D G3DSA:1.20.1250.20 40 243 1.3E-31 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1154 1164 3.7E-30 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 951 965 3.7E-30 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1257 1269 3.7E-30 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1233 1252 3.7E-30 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 1132 1143 3.7E-30 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00119 P-type cation-transporting ATPase superfamily signature 791 805 3.7E-30 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SMART SM00831 635 706 4.2E-5 T 17-03-2017 IPR004014 Cation-transporting P-type ATPase, N-terminal Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF81665 852 945 5.23E-58 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF81665 635 744 5.23E-58 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF81665 1283 1471 5.23E-58 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF81653 746 848 1.02E-26 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Gene3D G3DSA:1.20.1110.10 1202 1462 3.2E-62 T 17-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Gene3D G3DSA:1.20.1110.10 686 738 3.2E-62 T 17-03-2017 IPR023298 P-type ATPase, transmembrane domain Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Gene3D G3DSA:3.30.70.100 76 123 4.4E-5 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 1205 1316 1.7E-26 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 TIGRFAM TIGR01494 ATPase_P-type: HAD ATPase, P-type, family IC 716 970 1.8E-32 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Gene3D G3DSA:2.70.150.10 739 849 2.4E-31 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Gene3D G3DSA:2.70.150.10 654 685 2.4E-31 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 ProSitePatterns PS00154 E1-E2 ATPases phosphorylation site. 953 959 - T 17-03-2017 IPR018303 P-type ATPase, phosphorylation site Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Pfam PF00702 haloacid dehalogenase-like hydrolase 948 1247 5.5E-24 T 17-03-2017 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Pfam PF00122 E1-E2 ATPase 712 942 1.8E-51 T 17-03-2017 IPR008250 P-type ATPase, A domain GO:0000166|GO:0046872 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1092 1110 1.9E-15 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1205 1221 1.9E-15 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1265 1290 1.9E-15 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 PRINTS PR00120 H+-transporting ATPase (proton pump) signature 1233 1249 1.9E-15 T 17-03-2017 IPR001757 P-type ATPase GO:0016021 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF81660 1001 1136 9.37E-17 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF55008 68 124 7.55E-5 T 17-03-2017 IPR006121 Heavy metal-associated domain, HMA GO:0030001|GO:0046872 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Pfam PF00689 Cation transporting ATPase, C-terminus 1318 1469 3.8E-16 T 17-03-2017 IPR006068 Cation-transporting P-type ATPase, C-terminal Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 Gene3D G3DSA:3.40.1110.10 942 1139 3.1E-24 T 17-03-2017 IPR023299 P-type ATPase, cytoplasmic domain N GO:0000166 Reactome: R-HSA-936837 SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF56784 949 969 3.04E-46 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS06980 e0f0902fab209d9b28c791aef555645e 1510 SUPERFAMILY SSF56784 1089 1338 3.04E-46 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS05185 1a9ce3ced7282a9840db9d83ee9ff20b 517 Gene3D G3DSA:2.115.10.20 11 299 1.4E-75 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS05185 1a9ce3ced7282a9840db9d83ee9ff20b 517 SUPERFAMILY SSF49899 319 513 9.5E-39 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS05185 1a9ce3ced7282a9840db9d83ee9ff20b 517 Pfam PF04616 Glycosyl hydrolases family 43 12 285 6.4E-75 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS05185 1a9ce3ced7282a9840db9d83ee9ff20b 517 SUPERFAMILY SSF75005 12 299 2.88E-80 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS05185 1a9ce3ced7282a9840db9d83ee9ff20b 517 Gene3D G3DSA:2.60.120.200 319 515 7.7E-41 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS02775 de98c6d229a023318bd19f2d5d4cb11d 395 SUPERFAMILY SSF52266 172 379 1.15E-25 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS02775 de98c6d229a023318bd19f2d5d4cb11d 395 Pfam PF14606 GDSL-like Lipase/Acylhydrolase family 178 277 9.5E-13 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS02775 de98c6d229a023318bd19f2d5d4cb11d 395 Gene3D G3DSA:3.40.50.1110 160 379 1.7E-11 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS42050 2c4cadbe1626a1c1fb22474926ce4a38 141 Gene3D G3DSA:3.30.1330.40 5 132 2.1E-32 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS42050 2c4cadbe1626a1c1fb22474926ce4a38 141 SUPERFAMILY SSF55298 6 131 7.54E-32 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS42050 2c4cadbe1626a1c1fb22474926ce4a38 141 Pfam PF01042 Endoribonuclease L-PSP 15 128 1.6E-20 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS19535 b4a453091b30109f0d63986bd6dc2bff 436 ProSitePatterns PS00216 Sugar transport proteins signature 1. 96 112 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS19535 b4a453091b30109f0d63986bd6dc2bff 436 Pfam PF07690 Major Facilitator Superfamily 49 298 3.9E-13 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS19535 b4a453091b30109f0d63986bd6dc2bff 436 Gene3D G3DSA:1.20.1250.20 43 213 3.8E-17 T 17-03-2017 SHXM_RS19535 b4a453091b30109f0d63986bd6dc2bff 436 Gene3D G3DSA:1.20.1250.20 238 417 1.2E-6 T 17-03-2017 SHXM_RS19535 b4a453091b30109f0d63986bd6dc2bff 436 SUPERFAMILY SSF103473 40 416 5.23E-31 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11270 906ef603bdf85dc887b272d65f6d10a7 261 Gene3D G3DSA:3.90.850.10 3 255 5.1E-87 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS11270 906ef603bdf85dc887b272d65f6d10a7 261 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 82 250 9.8E-14 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS11270 906ef603bdf85dc887b272d65f6d10a7 261 SUPERFAMILY SSF56529 3 254 2.22E-78 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS33255 ce95af427a93216813cb4d1317048c2f 678 Pfam PF03190 Protein of unknown function, DUF255 3 163 5.3E-73 T 17-03-2017 IPR004879 Domain of unknown function DUF255 SHXM_RS33255 ce95af427a93216813cb4d1317048c2f 678 Gene3D G3DSA:3.40.30.10 20 145 5.7E-32 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS33255 ce95af427a93216813cb4d1317048c2f 678 PIRSF PIRSF006402 1 677 5.7E-204 T 17-03-2017 IPR024705 Spermatogenesis-associated protein 20 SHXM_RS33255 ce95af427a93216813cb4d1317048c2f 678 SUPERFAMILY SSF52833 1 127 8.29E-29 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS33255 ce95af427a93216813cb4d1317048c2f 678 SUPERFAMILY SSF48208 192 538 1.45E-72 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS33255 ce95af427a93216813cb4d1317048c2f 678 Gene3D G3DSA:1.50.10.10 194 323 7.4E-17 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS28805 27aedd2a97cb672e8ca193523b1adb23 303 Gene3D G3DSA:3.10.310.10 8 131 3.9E-36 T 17-03-2017 SHXM_RS28805 27aedd2a97cb672e8ca193523b1adb23 303 Gene3D G3DSA:3.10.310.10 132 289 2.1E-39 T 17-03-2017 SHXM_RS28805 27aedd2a97cb672e8ca193523b1adb23 303 SUPERFAMILY SSF54506 8 299 1.44E-56 T 17-03-2017 SHXM_RS28805 27aedd2a97cb672e8ca193523b1adb23 303 PIRSF PIRSF016184 5 302 2.8E-57 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS28805 27aedd2a97cb672e8ca193523b1adb23 303 Pfam PF02567 Phenazine biosynthesis-like protein 13 298 4.5E-66 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS28805 27aedd2a97cb672e8ca193523b1adb23 303 TIGRFAM TIGR00654 PhzF_family: phenazine biosynthesis protein, PhzF family 8 298 1.8E-49 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 Gene3D G3DSA:3.40.190.10 91 180 6.3E-18 T 17-03-2017 SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 Gene3D G3DSA:1.10.10.10 2 88 2.6E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 Pfam PF03466 LysR substrate binding domain 89 295 2.1E-44 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 1.7E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 SUPERFAMILY SSF46785 2 110 1.48E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 SUPERFAMILY SSF53850 91 297 2.72E-41 T 17-03-2017 SHXM_RS39750 0475dca6d34d390bd029dd146046b06c 302 Gene3D G3DSA:3.40.190.10 181 269 4.1E-28 T 17-03-2017 SHXM_RS42955 565aa6b4c1dda1f5b4186fd76c3215af 256 SMART SM00382 27 243 4.8E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS42955 565aa6b4c1dda1f5b4186fd76c3215af 256 Pfam PF00005 ABC transporter 23 167 1.7E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS42955 565aa6b4c1dda1f5b4186fd76c3215af 256 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS42955 565aa6b4c1dda1f5b4186fd76c3215af 256 Gene3D G3DSA:3.40.50.300 3 226 3.8E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42955 565aa6b4c1dda1f5b4186fd76c3215af 256 SUPERFAMILY SSF52540 3 224 3.02E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31405 b1e7619604f5bf4f4cb582eb9b82225f 415 Gene3D G3DSA:1.20.1250.20 17 191 1.3E-23 T 17-03-2017 SHXM_RS31405 b1e7619604f5bf4f4cb582eb9b82225f 415 Gene3D G3DSA:1.20.1250.20 212 396 3.0E-12 T 17-03-2017 SHXM_RS31405 b1e7619604f5bf4f4cb582eb9b82225f 415 SUPERFAMILY SSF103473 17 396 1.1E-42 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS31405 b1e7619604f5bf4f4cb582eb9b82225f 415 Pfam PF07690 Major Facilitator Superfamily 20 361 5.3E-29 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 Gene3D G3DSA:1.10.357.10 58 194 3.5E-21 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 60 2.7E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 SUPERFAMILY SSF48498 86 144 4.23E-5 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 Gene3D G3DSA:1.10.10.60 4 57 4.0E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 2.3E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 2.3E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22595 a4f90517d8f2536ba877efe7768407bc 208 SUPERFAMILY SSF46689 4 68 1.2E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 SUPERFAMILY SSF52922 193 324 5.23E-38 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 Gene3D G3DSA:3.40.50.970 4 189 9.7E-75 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 SUPERFAMILY SSF52518 5 184 1.42E-67 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 SMART SM00861 6 181 1.3E-69 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 Gene3D G3DSA:3.40.50.920 198 320 1.8E-42 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 Pfam PF02779 Transketolase, pyrimidine binding domain 5 180 3.3E-46 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS28440 27ea78c367d535234ea4eaeb6d4f1ce0 326 Pfam PF02780 Transketolase, C-terminal domain 197 315 8.3E-38 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS41560 b3256616539450fb5c8463c4882e2fc3 216 Gene3D G3DSA:3.40.30.10 3 54 2.0E-7 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS41560 b3256616539450fb5c8463c4882e2fc3 216 SUPERFAMILY SSF52833 3 151 1.27E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS43395 2f2410754c4c069413a3da03b51df07c 307 SUPERFAMILY SSF48576 74 298 1.55E-11 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS43395 2f2410754c4c069413a3da03b51df07c 307 Gene3D G3DSA:1.10.600.10 135 248 1.4E-7 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS40765 94ab3419bec2e54485ff2c193929e6be 273 SUPERFAMILY SSF53474 5 259 3.22E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40765 94ab3419bec2e54485ff2c193929e6be 273 Gene3D G3DSA:3.40.50.1820 4 262 5.7E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40765 94ab3419bec2e54485ff2c193929e6be 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 55 70 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS40765 94ab3419bec2e54485ff2c193929e6be 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 114 127 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS40765 94ab3419bec2e54485ff2c193929e6be 273 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS40765 94ab3419bec2e54485ff2c193929e6be 273 Pfam PF12697 Alpha/beta hydrolase family 29 250 3.3E-21 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS08745 cb5f4bd07641356ee7040dc3479d5be9 693 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 546 611 2.6E-8 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS08745 cb5f4bd07641356ee7040dc3479d5be9 693 Gene3D G3DSA:3.40.50.1390 21 143 1.5E-11 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08745 cb5f4bd07641356ee7040dc3479d5be9 693 ProSitePatterns PS00397 Site-specific recombinases active site. 25 33 - T 17-03-2017 IPR006118 Recombinase, conserved site GO:0000150|GO:0006310 SHXM_RS08745 cb5f4bd07641356ee7040dc3479d5be9 693 Pfam PF00239 Resolvase, N terminal domain 23 172 1.1E-19 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08745 cb5f4bd07641356ee7040dc3479d5be9 693 SUPERFAMILY SSF53041 21 171 6.41E-18 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS08745 cb5f4bd07641356ee7040dc3479d5be9 693 SMART SM00857 22 173 1.9E-17 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 Pfam PF08220 DeoR-like helix-turn-helix domain 6 56 1.9E-15 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 5.1E-9 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 5.1E-9 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 SMART SM01134 73 234 3.8E-66 T 17-03-2017 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 Pfam PF00455 DeoR C terminal sensor domain 76 233 2.3E-48 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 SUPERFAMILY SSF46785 5 58 1.38E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 SUPERFAMILY SSF100950 76 237 1.36E-25 T 17-03-2017 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 Gene3D G3DSA:1.10.10.10 5 82 5.8E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 Gene3D G3DSA:3.40.50.1360 83 215 2.2E-8 T 17-03-2017 SHXM_RS32360 4eecc81da5798aadb9559a57a8decd71 253 SMART SM00420 6 58 5.7E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS41375 7809c97a56a570adfa69ce802ca5a071 206 SUPERFAMILY SSF55821 1 203 1.37E-58 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS41375 7809c97a56a570adfa69ce802ca5a071 206 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 7 201 9.0E-53 T 17-03-2017 IPR006070 YrdC-like domain GO:0003725 SHXM_RS41375 7809c97a56a570adfa69ce802ca5a071 206 Pfam PF01300 Telomere recombination 23 198 3.0E-43 T 17-03-2017 IPR006070 YrdC-like domain GO:0003725 SHXM_RS41375 7809c97a56a570adfa69ce802ca5a071 206 Gene3D G3DSA:3.90.870.10 2 203 1.4E-59 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS38475 c5319dd9a8154eabb90e7d08906fa707 374 SUPERFAMILY SSF52540 103 214 2.83E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38475 c5319dd9a8154eabb90e7d08906fa707 374 Pfam PF03969 AFG1-like ATPase 62 361 1.2E-55 T 17-03-2017 IPR005654 ATPase, AFG1-like GO:0005524 SHXM_RS38475 c5319dd9a8154eabb90e7d08906fa707 374 Gene3D G3DSA:3.40.50.300 34 230 4.5E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 PRINTS PR00132 Glycosyl hydrolase family 2 signature 485 500 1.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 PRINTS PR00132 Glycosyl hydrolase family 2 signature 401 416 1.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 PRINTS PR00132 Glycosyl hydrolase family 2 signature 326 344 1.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 PRINTS PR00132 Glycosyl hydrolase family 2 signature 295 309 1.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 PRINTS PR00132 Glycosyl hydrolase family 2 signature 132 147 1.3E-32 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 ProSitePatterns PS00719 Glycosyl hydrolases family 2 signature 1. 336 361 - T 17-03-2017 IPR023230 Glycoside hydrolase, family 2, conserved site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Gene3D G3DSA:2.60.40.320 194 284 1.8E-13 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 SUPERFAMILY SSF49303 575 681 2.73E-28 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 287 583 9.2E-104 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 SUPERFAMILY SSF74650 700 973 1.19E-76 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Gene3D G3DSA:3.20.20.80 286 577 1.4E-99 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 SUPERFAMILY SSF49785 22 204 5.1E-57 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 37 204 5.5E-36 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 SUPERFAMILY SSF49303 208 285 1.44E-10 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 SMART SM01038 703 973 9.8E-106 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 ProSitePatterns PS00608 Glycosyl hydrolases family 2 acid/base catalyst. 401 415 - T 17-03-2017 IPR023232 Glycoside hydrolase, family 2, active site KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Pfam PF16353 Domain of unknown function(DUF4981) 592 678 9.9E-25 T 17-03-2017 IPR032312 Beta-galactosidase, domain 4 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Gene3D G3DSA:2.70.98.10 709 973 2.1E-79 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Gene3D G3DSA:2.60.40.320 580 681 9.8E-31 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 SUPERFAMILY SSF51445 286 577 5.39E-95 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Pfam PF02929 Beta galactosidase small chain 709 972 9.5E-62 T 17-03-2017 IPR004199 Beta galactosidase small chain/ domain 5 GO:0004565|GO:0005975|GO:0009341 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS11445 3a40ce5e12d5e8ceeb87a8f388df9ac1 976 Gene3D G3DSA:2.60.120.260 30 193 1.2E-63 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS19525 f4472d485438a575e674baa40f84626a 79 Gene3D G3DSA:1.10.10.10 18 65 4.6E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19525 f4472d485438a575e674baa40f84626a 79 SUPERFAMILY SSF46689 23 77 1.7E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19525 f4472d485438a575e674baa40f84626a 79 Pfam PF13384 Homeodomain-like domain 28 72 3.6E-10 T 17-03-2017 SHXM_RS16835 583fae4f47d328dbb9bb4895cecffc11 731 Pfam PF04183 IucA / IucC family 282 501 4.6E-29 T 17-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 SHXM_RS16835 583fae4f47d328dbb9bb4895cecffc11 731 Pfam PF06276 Ferric iron reductase FhuF-like transporter 529 696 4.4E-5 T 17-03-2017 IPR022770 Ferric iron reductase FhuF domain SHXM_RS12475 d9cf5d0098949f284352686989517049 290 Gene3D G3DSA:3.40.50.300 2 229 3.6E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12475 d9cf5d0098949f284352686989517049 290 Pfam PF00005 ABC transporter 21 159 7.5E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12475 d9cf5d0098949f284352686989517049 290 SUPERFAMILY SSF52540 3 230 4.72E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12475 d9cf5d0098949f284352686989517049 290 ProSitePatterns PS00211 ABC transporters family signature. 132 146 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS12475 d9cf5d0098949f284352686989517049 290 SMART SM00382 30 216 2.6E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 TIGRFAM TIGR03455 HisG_C-term: ATP phosphoribosyltransferase, C-terminal domain 190 281 9.5E-29 T 17-03-2017 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 Pfam PF08029 HisG, C-terminal domain 207 278 8.6E-25 T 17-03-2017 IPR013115 Histidine biosynthesis HisG, C-terminal GO:0000105|GO:0000287|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 ProSitePatterns PS01316 ATP phosphoribosyltransferase signature. 141 162 - T 17-03-2017 IPR018198 ATP phosphoribosyltransferase, conserved site GO:0003879 KEGG: 00340+2.4.2.17 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 Gene3D G3DSA:3.40.190.10 1 108 1.6E-32 T 17-03-2017 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 Gene3D G3DSA:3.40.190.10 109 173 1.0E-23 T 17-03-2017 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 Pfam PF01634 ATP phosphoribosyltransferase 49 203 2.9E-41 T 17-03-2017 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 TIGRFAM TIGR00070 hisG: ATP phosphoribosyltransferase 2 182 3.5E-51 T 17-03-2017 IPR013820 ATP phosphoribosyltransferase, catalytic domain GO:0000105|GO:0003879|GO:0005737 KEGG: 00340+2.4.2.17 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 Gene3D G3DSA:3.30.70.120 210 281 5.5E-27 T 17-03-2017 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 SUPERFAMILY SSF53850 1 208 5.79E-59 T 17-03-2017 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 Hamap MF_00079 ATP phosphoribosyltransferase [hisG]. 1 282 31.517 T 17-03-2017 IPR020621 ATP phosphoribosyltransferase HisG, long form GO:0000105|GO:0003879 KEGG: 00340+2.4.2.17 SHXM_RS12140 c724b9395200844125a77f0b540b8741 282 SUPERFAMILY SSF54913 210 281 1.78E-20 T 17-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 SUPERFAMILY SSF53328 1 206 8.37E-56 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 Gene3D G3DSA:3.10.25.10 208 309 3.6E-34 T 17-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 SUPERFAMILY SSF50486 205 308 1.88E-29 T 17-03-2017 IPR011034 Formyl transferase, C-terminal-like GO:0003824 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 Hamap MF_00182 Methionyl-tRNA formyltransferase [fmt]. 1 303 32.575 T 17-03-2017 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9|Reactome: R-HSA-5368286 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 Pfam PF02911 Formyl transferase, C-terminal domain 204 300 5.6E-26 T 17-03-2017 IPR005793 Formyl transferase, C-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 Pfam PF00551 Formyl transferase 2 174 4.7E-33 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 TIGRFAM TIGR00460 fmt: methionyl-tRNA formyltransferase 1 301 4.3E-68 T 17-03-2017 IPR005794 Methionyl-tRNA formyltransferase GO:0004479|GO:0071951 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9|Reactome: R-HSA-5368286 SHXM_RS12300 d6e4c064eabbf5b9f11e84189039854d 310 Gene3D G3DSA:3.40.50.170 1 206 4.4E-58 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 SUPERFAMILY SSF63411 265 451 1.53E-48 T 17-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 ProSitePatterns PS00143 Insulinase family, zinc-binding region signature. 66 89 - T 17-03-2017 IPR001431 Peptidase M16, zinc-binding site GO:0004222|GO:0006508 SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 Pfam PF00675 Insulinase (Peptidase family M16) 45 192 6.1E-34 T 17-03-2017 IPR011765 Peptidase M16, N-terminal SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 Gene3D G3DSA:3.30.830.10 270 448 2.9E-58 T 17-03-2017 IPR011237 Peptidase M16 domain GO:0046872 SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 SUPERFAMILY SSF63411 34 238 1.59E-57 T 17-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 Gene3D G3DSA:3.30.830.10 35 239 8.3E-55 T 17-03-2017 IPR011237 Peptidase M16 domain GO:0046872 SHXM_RS37075 3b69cfebed626aeef3fe8ebe8f3703e9 459 Pfam PF05193 Peptidase M16 inactive domain 200 380 1.1E-42 T 17-03-2017 IPR007863 Peptidase M16, C-terminal SHXM_RS38445 ab4b63a12177381b5cdb4ed3030de36a 174 Pfam PF08877 MepB protein 35 155 6.7E-50 T 17-03-2017 IPR011235 MepB-like SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 SUPERFAMILY SSF51735 3 185 4.48E-91 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 SUPERFAMILY SSF51735 297 356 4.48E-91 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 SUPERFAMILY SSF55347 190 299 8.37E-34 T 17-03-2017 SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 PIRSF PIRSF015578 1 360 1.7E-90 T 17-03-2017 IPR002587 Myo-inositol-1-phosphate synthase GO:0004512|GO:0006021|GO:0008654 KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 Gene3D G3DSA:3.40.50.720 1 189 2.4E-114 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 Gene3D G3DSA:3.40.50.720 301 355 2.4E-114 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 TIGRFAM TIGR03450 mycothiol_INO1: inositol 1-phosphate synthase 4 354 3.0E-218 T 17-03-2017 IPR017815 Myo-inositol 1-phosphate synthase, actinobacteria SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 Gene3D G3DSA:3.30.360.10 190 300 5.4E-47 T 17-03-2017 SHXM_RS28025 ffd8a0bd542dbc2c92733ae0523adb9f 360 Pfam PF01658 Myo-inositol-1-phosphate synthase 191 300 5.8E-31 T 17-03-2017 IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like KEGG: 00521+5.5.1.4|KEGG: 00562+5.5.1.4|MetaCyc: PWY-2301|MetaCyc: PWY-4661|MetaCyc: PWY-6372|MetaCyc: PWY-6580|MetaCyc: PWY-6664|Reactome: R-HSA-1855183 SHXM_RS33130 956c7aa4429d2836dbfbea51b5984637 554 Gene3D G3DSA:3.30.450.40 126 284 2.7E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS33130 956c7aa4429d2836dbfbea51b5984637 554 SUPERFAMILY SSF55781 231 286 6.87E-5 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS33130 956c7aa4429d2836dbfbea51b5984637 554 SMART SM00331 307 527 2.4E-33 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33130 956c7aa4429d2836dbfbea51b5984637 554 SUPERFAMILY SSF81606 322 525 1.57E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33130 956c7aa4429d2836dbfbea51b5984637 554 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 335 526 2.2E-37 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33130 956c7aa4429d2836dbfbea51b5984637 554 Gene3D G3DSA:3.60.40.10 449 525 4.4E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS30710 47a10fd26bb7faf3cf4dfe61d9ce27e2 272 Gene3D G3DSA:3.40.190.10 73 174 4.9E-37 T 17-03-2017 SHXM_RS30710 47a10fd26bb7faf3cf4dfe61d9ce27e2 272 Pfam PF02621 Menaquinone biosynthesis 1 256 9.6E-73 T 17-03-2017 IPR003773 Menaquinone biosynthesis enzyme SHXM_RS30710 47a10fd26bb7faf3cf4dfe61d9ce27e2 272 Gene3D G3DSA:3.40.190.10 1 72 1.6E-65 T 17-03-2017 SHXM_RS30710 47a10fd26bb7faf3cf4dfe61d9ce27e2 272 Gene3D G3DSA:3.40.190.10 175 271 1.6E-65 T 17-03-2017 SHXM_RS30710 47a10fd26bb7faf3cf4dfe61d9ce27e2 272 SUPERFAMILY SSF53850 1 255 8.54E-78 T 17-03-2017 SHXM_RS30710 47a10fd26bb7faf3cf4dfe61d9ce27e2 272 Hamap MF_00995 Chorismate dehydratase [mqnA]. 1 262 29.739 T 17-03-2017 IPR030868 Chorismate dehydratase GO:0009234|GO:0016829 KEGG: 00130+4.2.1.151|MetaCyc: PWY-7371|MetaCyc: PWY-7374 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 Gene3D G3DSA:3.50.50.60 276 351 3.3E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 Gene3D G3DSA:3.50.50.60 3 184 3.3E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 9.8E-18 T 17-03-2017 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 303 319 9.8E-18 T 17-03-2017 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 288 303 9.8E-18 T 17-03-2017 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 158 173 9.8E-18 T 17-03-2017 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 SUPERFAMILY SSF51905 275 361 1.09E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 SUPERFAMILY SSF51905 5 179 1.09E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44930 d2f09c109325a5b1dc1e4a9edae18359 417 Pfam PF01494 FAD binding domain 4 329 3.3E-51 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS36665 0f586f379e714cb4ac267b11c438dedb 260 SUPERFAMILY SSF53633 22 255 2.62E-67 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS36665 0f586f379e714cb4ac267b11c438dedb 260 Hamap MF_01220_B Uridylate kinase [pyrH]. 20 254 42.814 T 17-03-2017 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22 SHXM_RS36665 0f586f379e714cb4ac267b11c438dedb 260 Pfam PF00696 Amino acid kinase family 26 232 1.9E-23 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS36665 0f586f379e714cb4ac267b11c438dedb 260 PIRSF PIRSF005650 18 260 1.6E-88 T 17-03-2017 IPR011817 Uridylate kinase GO:0006221|GO:0009041 KEGG: 00240+2.7.4.22 SHXM_RS36665 0f586f379e714cb4ac267b11c438dedb 260 Gene3D G3DSA:3.40.1160.10 14 254 2.9E-81 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS36665 0f586f379e714cb4ac267b11c438dedb 260 TIGRFAM TIGR02075 pyrH_bact: UMP kinase 24 254 3.7E-90 T 17-03-2017 IPR015963 Uridylate kinase, bacteria GO:0005737|GO:0006221|GO:0033862 KEGG: 00240+2.7.4.22 SHXM_RS37265 44da0ea351cc763d8a0093c0750090ff 314 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 82 273 6.9E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS37265 44da0ea351cc763d8a0093c0750090ff 314 SUPERFAMILY SSF161098 63 274 3.14E-39 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS37265 44da0ea351cc763d8a0093c0750090ff 314 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 62 163 5.0E-17 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS37265 44da0ea351cc763d8a0093c0750090ff 314 Gene3D G3DSA:1.10.3720.10 62 274 9.1E-45 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03780 152312b745b34ee74efd8d5116fe5f04 398 Pfam PF07690 Major Facilitator Superfamily 19 296 7.8E-30 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS03780 152312b745b34ee74efd8d5116fe5f04 398 Gene3D G3DSA:1.20.1250.20 9 200 3.5E-28 T 17-03-2017 SHXM_RS03780 152312b745b34ee74efd8d5116fe5f04 398 ProSitePatterns PS00216 Sugar transport proteins signature 1. 66 82 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS03780 152312b745b34ee74efd8d5116fe5f04 398 SUPERFAMILY SSF103473 1 389 2.49E-50 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS03780 152312b745b34ee74efd8d5116fe5f04 398 Gene3D G3DSA:1.20.1250.20 211 389 1.1E-10 T 17-03-2017 SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 SUPERFAMILY SSF56349 163 238 8.95E-13 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 SUPERFAMILY SSF56349 298 420 8.95E-13 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 SUPERFAMILY SSF47823 24 106 1.26E-6 T 17-03-2017 IPR010998 Integrase, Lambda-type, N-terminal SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 Gene3D G3DSA:1.10.150.130 23 105 5.7E-9 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 Pfam PF02899 Phage integrase, N-terminal SAM-like domain 24 97 6.4E-7 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 Gene3D G3DSA:1.10.443.10 164 251 9.4E-20 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS21490 2db2c1247fd7dc006c33770afefde3fb 470 Gene3D G3DSA:1.10.443.10 311 418 9.4E-20 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS36710 ea3cf19c8424eb23f73a15db4dce5d27 241 Pfam PF00005 ABC transporter 27 174 8.3E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS36710 ea3cf19c8424eb23f73a15db4dce5d27 241 SMART SM00382 34 222 9.7E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36710 ea3cf19c8424eb23f73a15db4dce5d27 241 Gene3D G3DSA:3.40.50.300 8 226 1.6E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36710 ea3cf19c8424eb23f73a15db4dce5d27 241 SUPERFAMILY SSF52540 9 228 6.25E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 PRINTS PR00732 Glycosyl hydrolase family 4 signature 2 17 4.4E-34 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 PRINTS PR00732 Glycosyl hydrolase family 4 signature 92 105 4.4E-34 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 PRINTS PR00732 Glycosyl hydrolase family 4 signature 106 126 4.4E-34 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 PRINTS PR00732 Glycosyl hydrolase family 4 signature 135 152 4.4E-34 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 PRINTS PR00732 Glycosyl hydrolase family 4 signature 185 197 4.4E-34 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 PRINTS PR00732 Glycosyl hydrolase family 4 signature 71 87 4.4E-34 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 Gene3D G3DSA:3.90.110.10 162 417 3.5E-88 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 Gene3D G3DSA:3.40.50.720 2 156 2.1E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 Pfam PF02056 Family 4 glycosyl hydrolase 2 179 1.6E-44 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 SUPERFAMILY SSF51735 1 155 1.41E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 190 396 2.2E-43 T 17-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 SHXM_RS21930 afe1ec2cb64fadc9be33c88b9a5ee32a 420 SUPERFAMILY SSF56327 165 417 6.09E-66 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PIRSF PIRSF000126 1 253 3.8E-63 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 5.5E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 5.5E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 5.5E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 78 89 5.5E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 5.5E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 Pfam PF00106 short chain dehydrogenase 3 188 2.3E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 Gene3D G3DSA:3.40.50.720 3 212 3.7E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 78 89 3.4E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 3.4E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 3.4E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31545 2b5a688e4c4198e4650d553d770623cf 257 SUPERFAMILY SSF51735 3 239 5.92E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 Gene3D G3DSA:3.40.190.10 179 262 2.9E-14 T 17-03-2017 SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 48 59 1.8E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 38 48 1.8E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 27 38 1.8E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 Pfam PF03466 LysR substrate binding domain 104 289 2.2E-27 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 Gene3D G3DSA:1.10.10.10 10 95 5.7E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 SUPERFAMILY SSF53850 103 294 8.03E-27 T 17-03-2017 SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 SUPERFAMILY SSF46785 10 92 4.85E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 12 71 2.7E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33020 07d56f80407bda5dd4eb77b6dd5e2073 304 Gene3D G3DSA:3.40.190.10 102 178 1.2E-16 T 17-03-2017 SHXM_RS17370 99fe8a2bd2394579fd8f909ed1bf43d3 539 Pfam PF00474 Sodium:solute symporter family 46 462 1.1E-95 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS17370 99fe8a2bd2394579fd8f909ed1bf43d3 539 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 46 461 6.9E-59 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS43790 d60c7b6d5b3e02e6fa1142e4c8557f7f 897 SMART SM00387 519 629 1.2E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43790 d60c7b6d5b3e02e6fa1142e4c8557f7f 897 Pfam PF08376 Nitrate and nitrite sensing 58 300 2.2E-30 T 17-03-2017 IPR013587 Nitrate/nitrite sensing protein SHXM_RS43790 d60c7b6d5b3e02e6fa1142e4c8557f7f 897 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 523 626 8.1E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43790 d60c7b6d5b3e02e6fa1142e4c8557f7f 897 Gene3D G3DSA:3.30.565.10 488 629 3.2E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43790 d60c7b6d5b3e02e6fa1142e4c8557f7f 897 Pfam PF00672 HAMP domain 319 403 8.2E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS43790 d60c7b6d5b3e02e6fa1142e4c8557f7f 897 SUPERFAMILY SSF55874 506 626 3.01E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18390 38d5b3067851c8e19d5ed8748a5a6cca 256 Gene3D G3DSA:3.20.20.70 6 256 5.9E-102 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18390 38d5b3067851c8e19d5ed8748a5a6cca 256 SUPERFAMILY SSF51366 3 256 2.2E-82 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS18390 38d5b3067851c8e19d5ed8748a5a6cca 256 Pfam PF00977 Histidine biosynthesis protein 6 239 4.5E-86 T 17-03-2017 IPR006062 Histidine biosynthesis GO:0000105 SHXM_RS18390 38d5b3067851c8e19d5ed8748a5a6cca 256 TIGRFAM TIGR00735 hisF: imidazoleglycerol phosphate synthase, cyclase subunit 3 256 1.1E-108 T 17-03-2017 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 SHXM_RS18390 38d5b3067851c8e19d5ed8748a5a6cca 256 Hamap MF_01013 Imidazole glycerol phosphate synthase subunit HisF [hisF]. 2 256 47.254 T 17-03-2017 IPR004651 Histidine biosynthesis, HisF GO:0000105|GO:0000107|GO:0005737 SHXM_RS02395 1d5d064090dde847203a64a1ef72cf57 504 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 82 411 5.6E-78 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS02395 1d5d064090dde847203a64a1ef72cf57 504 Gene3D G3DSA:3.40.190.10 193 291 2.8E-34 T 17-03-2017 SHXM_RS02395 1d5d064090dde847203a64a1ef72cf57 504 Gene3D G3DSA:3.10.105.10 292 472 3.7E-37 T 17-03-2017 SHXM_RS02395 1d5d064090dde847203a64a1ef72cf57 504 SUPERFAMILY SSF53850 37 492 1.47E-107 T 17-03-2017 SHXM_RS02395 1d5d064090dde847203a64a1ef72cf57 504 Gene3D G3DSA:3.90.76.10 48 192 2.4E-38 T 17-03-2017 SHXM_RS02395 1d5d064090dde847203a64a1ef72cf57 504 PIRSF PIRSF002741 3 498 2.2E-85 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 Gene3D G3DSA:3.40.50.620 37 326 2.3E-75 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 SUPERFAMILY SSF52374 33 333 1.54E-66 T 17-03-2017 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 TIGRFAM TIGR03447 mycothiol_MshC: cysteine--1-D-myo-inosityl 2-amino-2-deoxy-alpha-D-glucopyranoside ligase 3 409 3.7E-203 T 17-03-2017 IPR017812 Mycothiol ligase MshC GO:0010125|GO:0035446 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 Hamap MF_01697 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase [mshC]. 9 409 53.229 T 17-03-2017 IPR017812 Mycothiol ligase MshC GO:0010125|GO:0035446 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 39 333 2.6E-80 T 17-03-2017 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 40 51 3.5E-18 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 76 85 3.5E-18 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 241 262 3.5E-18 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS16055 e72946ff11d56d277efde0681a17b568 409 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 210 228 3.5E-18 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 TIGRFAM TIGR03797 NHLM_micro_ABC2: NHLM bacteriocin system ABC transporter, ATP-binding protein 274 956 5.2E-267 T 17-03-2017 IPR022515 NHPM bacteriocin system ABC transporter, ATP-binding protein SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 ProSitePatterns PS00211 ABC transporters family signature. 858 872 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 SUPERFAMILY SSF52540 715 952 3.28E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 SUPERFAMILY SSF90123 397 707 6.15E-38 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 Gene3D G3DSA:1.20.1560.10 403 706 1.8E-34 T 17-03-2017 SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 Pfam PF00664 ABC transporter transmembrane region 415 677 7.1E-18 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 Pfam PF00005 ABC transporter 739 886 1.7E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 Gene3D G3DSA:3.40.50.300 722 945 4.3E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04195 9843254e060e780f2a05c475ddfc490d 957 SMART SM00382 748 924 1.7E-20 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30200 e305a8e203cb62e7731336c55ee9c522 377 SUPERFAMILY SSF51395 12 362 9.29E-95 T 17-03-2017 SHXM_RS30200 e305a8e203cb62e7731336c55ee9c522 377 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 16 302 1.7E-60 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS30200 e305a8e203cb62e7731336c55ee9c522 377 Gene3D G3DSA:3.20.20.70 11 364 1.2E-100 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 Gene3D G3DSA:3.40.50.2300 191 344 2.5E-48 T 17-03-2017 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 Gene3D G3DSA:3.40.50.2300 61 190 4.2E-28 T 17-03-2017 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 SMART SM00354 11 81 4.0E-19 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 Gene3D G3DSA:1.10.260.40 10 60 1.1E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 SUPERFAMILY SSF53822 85 345 2.94E-57 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 Pfam PF13377 Periplasmic binding protein-like domain 184 342 3.8E-35 T 17-03-2017 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 13 58 2.1E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS11210 385d720dc2ddebe7ebd6b67f35ce494a 347 SUPERFAMILY SSF47413 11 69 1.03E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49620 b5c9959e10a603af4d7afc3ca142bccb 278 SUPERFAMILY SSF52266 41 266 3.0E-54 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS49620 b5c9959e10a603af4d7afc3ca142bccb 278 Gene3D G3DSA:3.40.50.1110 38 267 2.7E-62 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS49620 b5c9959e10a603af4d7afc3ca142bccb 278 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 45 266 9.0E-25 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 SMART SM00829 10 309 1.5E-15 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 Gene3D G3DSA:3.90.180.10 1 150 2.9E-44 T 17-03-2017 IPR011032 GroES-like SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 SUPERFAMILY SSF51735 118 280 5.04E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 SUPERFAMILY SSF50129 1 149 9.28E-38 T 17-03-2017 IPR011032 GroES-like SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 Pfam PF13602 Zinc-binding dehydrogenase 188 309 1.9E-18 T 17-03-2017 SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 Gene3D G3DSA:3.40.50.720 151 243 1.6E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40240 1dab1ce4b87252d531481d756338a3d4 314 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 89 1.8E-8 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS12890 4c026cd94105cb3c92b448a8cb4bfcea 286 SUPERFAMILY SSF56219 34 282 5.5E-40 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS12890 4c026cd94105cb3c92b448a8cb4bfcea 286 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 44 270 2.0E-22 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS12890 4c026cd94105cb3c92b448a8cb4bfcea 286 Gene3D G3DSA:3.60.10.10 36 278 1.3E-17 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 SMART SM00829 41 407 4.7E-10 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 59 182 1.1E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 Gene3D G3DSA:3.90.180.10 42 224 2.3E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 TIGRFAM TIGR01751 crot-CoA-red: crotonyl-CoA carboxylase/reductase 25 420 2.0E-173 T 17-03-2017 IPR010085 Crotonyl-CoA reductase GO:0043880 KEGG: 00650+1.3.1.86 SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 SUPERFAMILY SSF51735 187 377 3.67E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 Gene3D G3DSA:3.40.50.720 225 356 2.3E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 Pfam PF00107 Zinc-binding dehydrogenase 228 372 4.4E-33 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS39570 beefb4348b5b3d6964b58cbf2a0597aa 446 SUPERFAMILY SSF50129 42 222 4.16E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS32480 967db7ffb87e3fc88a4637104da640c6 369 Pfam PF01758 Sodium Bile acid symporter family 58 254 1.3E-62 T 17-03-2017 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SHXM_RS32480 967db7ffb87e3fc88a4637104da640c6 369 TIGRFAM TIGR00832 acr3: arsenical-resistance protein 13 342 7.5E-134 T 17-03-2017 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SHXM_RS32480 967db7ffb87e3fc88a4637104da640c6 369 PIRSF PIRSF005508 1 359 6.2E-140 T 17-03-2017 IPR004706 Arsenical-resistance protein Acr3 GO:0015103|GO:0015297|GO:0016021 SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 PRINTS PR00171 Sugar transporter signature 382 394 6.1E-5 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 PRINTS PR00171 Sugar transporter signature 45 55 6.1E-5 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 PRINTS PR00171 Sugar transporter signature 128 147 6.1E-5 T 17-03-2017 IPR003663 Sugar/inositol transporter GO:0016020|GO:0022891|GO:0055085 SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 SUPERFAMILY SSF103473 20 448 1.31E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 Pfam PF00083 Sugar (and other) transporter 41 447 4.1E-47 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 Gene3D G3DSA:1.20.1250.20 270 448 3.5E-15 T 17-03-2017 SHXM_RS46390 e377924303db38d8d3fff1e9cef0c24f 457 Gene3D G3DSA:1.20.1250.20 40 218 5.0E-21 T 17-03-2017 SHXM_RS36230 28cc7ec3f66f480e55c6a7aadaec0fc0 527 Gene3D G3DSA:2.60.40.380 82 190 1.9E-13 T 17-03-2017 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 SHXM_RS36230 28cc7ec3f66f480e55c6a7aadaec0fc0 527 SUPERFAMILY SSF49363 78 189 9.94E-16 T 17-03-2017 IPR008963 Purple acid phosphatase-like, N-terminal GO:0003993|GO:0046872 SHXM_RS36230 28cc7ec3f66f480e55c6a7aadaec0fc0 527 Pfam PF00149 Calcineurin-like phosphoesterase 206 404 1.3E-13 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS36230 28cc7ec3f66f480e55c6a7aadaec0fc0 527 Pfam PF16656 Purple acid Phosphatase, N-terminal domain 82 187 1.5E-18 T 17-03-2017 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 SHXM_RS36230 28cc7ec3f66f480e55c6a7aadaec0fc0 527 SUPERFAMILY SSF56300 193 522 1.03E-45 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS36230 28cc7ec3f66f480e55c6a7aadaec0fc0 527 Gene3D G3DSA:3.60.21.10 192 526 1.2E-68 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 40 48 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 Pfam PF01799 [2Fe-2S] binding domain 173 235 2.2E-27 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 Gene3D G3DSA:3.10.20.30 2 77 1.0E-25 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 SUPERFAMILY SSF47741 173 242 5.76E-30 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 5 54 9.5E-7 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 Gene3D G3DSA:1.10.150.120 172 242 7.2E-32 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS38860 e9cdd51cd6fa59554853ab9621f83df4 246 SUPERFAMILY SSF54292 3 79 5.64E-21 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS13965 82d74cacef7ca0d9afabe7fff6ab9949 514 SUPERFAMILY SSF53383 33 485 5.35E-91 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS13965 82d74cacef7ca0d9afabe7fff6ab9949 514 Pfam PF00266 Aminotransferase class-V 167 286 5.5E-8 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS13965 82d74cacef7ca0d9afabe7fff6ab9949 514 Gene3D G3DSA:3.40.640.10 106 312 1.6E-26 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 Gene3D G3DSA:3.30.390.30 355 474 4.5E-32 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 341 7.6E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PIRSF PIRSF000350 1 476 1.1E-76 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 Gene3D G3DSA:3.50.50.60 158 349 1.9E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 1.4E-34 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 193 211 1.4E-34 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 154 172 1.4E-34 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 306 328 1.4E-34 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 277 293 1.4E-34 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 SUPERFAMILY SSF51905 3 350 2.66E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 Gene3D G3DSA:3.50.50.60 6 157 3.2E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 SUPERFAMILY SSF55424 357 475 7.56E-29 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 193 218 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 321 328 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 278 292 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 444 464 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 157 166 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 422 437 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 38 53 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 357 378 3.5E-53 T 17-03-2017 SHXM_RS24720 0edf9ea57d7a0fc9bcc21beaab2c5a1c 482 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 363 468 1.0E-23 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 SUPERFAMILY SSF81296 38 147 5.74E-20 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 Gene3D G3DSA:3.20.20.80 265 565 3.2E-70 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 Gene3D G3DSA:3.20.20.80 621 729 3.2E-70 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 Gene3D G3DSA:3.20.20.80 765 791 3.2E-70 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 SUPERFAMILY SSF81296 155 252 1.78E-18 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 Gene3D G3DSA:2.60.40.10 158 249 7.2E-14 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 Pfam PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) 157 235 3.9E-8 T 17-03-2017 IPR004193 Glycoside hydrolase, family 13, N-terminal GO:0004553|GO:0005975 Reactome: R-HSA-3322077|Reactome: R-HSA-3878781 SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 TIGRFAM TIGR02103 pullul_strch: alpha-1,6-glucosidases, pullulanase-type 45 882 2.2E-280 T 17-03-2017 IPR011839 Alpha-1,6-glucosidases, pullulanase-type GO:0005975|GO:0051060 SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 SUPERFAMILY SSF51445 247 789 5.63E-115 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 Pfam PF11852 Domain of unknown function (DUF3372) 733 882 2.1E-43 T 17-03-2017 IPR024561 Alpha-1,6-glucosidases, pullulanase-type, C-terminal SHXM_RS19245 8b3de8e423a7470789556b56728d2fa3 885 SUPERFAMILY SSF51011 793 882 1.08E-23 T 17-03-2017 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 SMART SM00861 933 1126 1.3E-52 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 SUPERFAMILY SSF52518 922 1132 1.68E-46 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Gene3D G3DSA:3.30.559.10 152 395 1.6E-51 T 17-03-2017 IPR023213 Chloramphenicol acetyltransferase-like domain Reactome: R-HSA-389661 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Pfam PF16078 2-oxoglutarate dehydrogenase N-terminus 26 62 3.3E-11 T 17-03-2017 IPR032106 2-oxoglutarate dehydrogenase E1 component, N-terminal domain KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 SUPERFAMILY SSF52518 463 870 1.62E-86 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Pfam PF02779 Transketolase, pyrimidine binding domain 932 1125 1.0E-57 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Pfam PF16870 2-oxoglutarate dehydrogenase C-terminal 1131 1279 1.4E-45 T 17-03-2017 IPR031717 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Gene3D G3DSA:3.40.50.970 505 872 1.4E-77 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 TIGRFAM TIGR00239 2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component 425 1279 0.0 T 17-03-2017 IPR011603 2-oxoglutarate dehydrogenase E1 component GO:0004591|GO:0006099|GO:0030976|GO:0055114 KEGG: 00020+1.2.4.2|KEGG: 00310+1.2.4.2|KEGG: 00380+1.2.4.2|MetaCyc: PWY-5084 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Pfam PF00676 Dehydrogenase E1 component 548 868 2.1E-54 T 17-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Gene3D G3DSA:3.40.50.970 935 1136 9.6E-22 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 SUPERFAMILY SSF52777 154 395 8.9E-55 T 17-03-2017 SHXM_RS34845 542365875127d8052a1c8b6e2dbafa2b 1281 Pfam PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) 165 395 3.5E-51 T 17-03-2017 IPR001078 2-oxoacid dehydrogenase acyltransferase, catalytic domain GO:0008152|GO:0016746 Reactome: R-HSA-389661 SHXM_RS10070 e3194895133c0193e8e369d793fa8ee8 361 Gene3D G3DSA:3.40.50.300 121 269 3.5E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10070 e3194895133c0193e8e369d793fa8ee8 361 SUPERFAMILY SSF52540 121 280 1.33E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10070 e3194895133c0193e8e369d793fa8ee8 361 SMART SM00382 129 273 3.6E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS10070 e3194895133c0193e8e369d793fa8ee8 361 Pfam PF07728 AAA domain (dynein-related subfamily) 132 262 2.3E-17 T 17-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 SHXM_RS14090 0e11afb80ef436d1a38f78851c046c85 252 Gene3D G3DSA:1.10.10.10 150 223 1.1E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14090 0e11afb80ef436d1a38f78851c046c85 252 SUPERFAMILY SSF46785 158 227 1.13E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14090 0e11afb80ef436d1a38f78851c046c85 252 Pfam PF00293 NUDIX domain 18 130 1.1E-13 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS14090 0e11afb80ef436d1a38f78851c046c85 252 SUPERFAMILY SSF55811 9 154 5.82E-26 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS14090 0e11afb80ef436d1a38f78851c046c85 252 Gene3D G3DSA:3.90.79.10 9 147 2.2E-39 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS19310 704d10b19f495ec85f4d0d97fc6ad061 69 Pfam PF04149 Domain of unknown function (DUF397) 5 58 2.1E-17 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS05610 fad928be00365f67603441889563cb17 216 Gene3D G3DSA:3.40.50.720 1 180 2.2E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05610 fad928be00365f67603441889563cb17 216 SUPERFAMILY SSF51735 1 188 2.55E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05610 fad928be00365f67603441889563cb17 216 Pfam PF00106 short chain dehydrogenase 1 182 5.6E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 SUPERFAMILY SSF46785 4 138 1.48E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 Gene3D G3DSA:1.10.10.10 4 137 4.7E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 SMART SM00347 25 125 3.8E-20 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 Pfam PF12802 MarR family 30 89 4.1E-13 T 17-03-2017 SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 PRINTS PR00598 Bacterial regulatory protein MarR family signature 66 81 1.5E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 PRINTS PR00598 Bacterial regulatory protein MarR family signature 115 135 1.5E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 PRINTS PR00598 Bacterial regulatory protein MarR family signature 49 65 1.5E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47060 fadb82781b681b4fdcb60e362bd8d2ad 141 PRINTS PR00598 Bacterial regulatory protein MarR family signature 85 101 1.5E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS09830 7425273afdba389a16cfaf3a65465ced 91 SUPERFAMILY SSF46689 12 81 2.15E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09830 7425273afdba389a16cfaf3a65465ced 91 Gene3D G3DSA:1.10.10.60 12 78 2.8E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 Gene3D G3DSA:3.40.50.720 88 221 9.8E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 Pfam PF06971 Putative DNA-binding protein N-terminus 16 63 4.4E-19 T 17-03-2017 IPR009718 Rex DNA-binding, C-terminal domain GO:0005737|GO:0045892|GO:0051775 SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 Pfam PF02629 CoA binding domain 91 188 4.5E-22 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 SUPERFAMILY SSF51735 93 214 3.45E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 SMART SM00881 89 190 6.4E-17 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 Hamap MF_01131 Redox-sensing transcriptional repressor Rex [rex]. 11 219 36.724 T 17-03-2017 IPR022876 Redox-sensing transcriptional repressor Rex GO:0005737|GO:0045892|GO:0051775 SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 Gene3D G3DSA:1.10.10.10 15 85 2.8E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30455 587b9ff878514daa342cfecc5ce87a5b 266 SUPERFAMILY SSF46785 17 89 2.26E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 Gene3D G3DSA:1.10.10.60 8 53 2.4E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 ProSitePatterns PS01081 TetR-type HTH domain signature. 24 55 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 SUPERFAMILY SSF46689 3 75 8.03E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 55 1.1E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 1.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 1.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS02480 5d96890162b2160aa2d06d93a8922ef6 189 Gene3D G3DSA:1.10.357.10 54 182 6.3E-16 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 Pfam PF00586 AIR synthase related protein, N-terminal domain 33 142 6.0E-22 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 TIGRFAM TIGR01379 thiL: thiamine-phosphate kinase 9 315 1.4E-84 T 17-03-2017 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 Pfam PF02769 AIR synthase related protein, C-terminal domain 156 245 9.5E-6 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 Hamap MF_02128 Thiamine-monophosphate kinase [thiL]. 8 312 28.789 T 17-03-2017 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 PIRSF PIRSF005303 3 315 1.1E-90 T 17-03-2017 IPR006283 Thiamine-monophosphate kinase GO:0009030|GO:0009228 KEGG: 00730+2.7.4.16|MetaCyc: PWY-6893|MetaCyc: PWY-6894|MetaCyc: PWY-6896|MetaCyc: PWY-6897 SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 Gene3D G3DSA:3.90.650.10 151 315 5.5E-52 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 SUPERFAMILY SSF55326 5 142 5.53E-35 T 17-03-2017 SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 Gene3D G3DSA:3.30.1330.10 4 145 5.4E-46 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS36405 cdde2264098205ed48849586515b2ad0 322 SUPERFAMILY SSF56042 148 296 4.88E-34 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 Gene3D G3DSA:2.70.98.10 37 368 5.0E-93 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 Gene3D G3DSA:1.20.1610.10 500 657 1.1E-40 T 17-03-2017 SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 Pfam PF07971 Glycosyl hydrolase family 92 285 785 5.9E-149 T 17-03-2017 IPR012939 Glycosyl hydrolase family 92 SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 Gene3D G3DSA:1.20.1050.60 394 485 1.4E-19 T 17-03-2017 SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 35 788 7.7E-149 T 17-03-2017 IPR005887 Alpha-1,2-mannosidase, putative SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 SUPERFAMILY SSF48208 308 728 1.09E-21 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS38125 6cb2f01cb358caef8926cf8134cf0b1d 1093 Gene3D G3DSA:3.30.2080.10 658 796 3.7E-50 T 17-03-2017 SHXM_RS45650 d5b9f2cf697f50c7afe5163966826eec 212 SUPERFAMILY SSF52317 19 209 1.16E-49 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS45650 d5b9f2cf697f50c7afe5163966826eec 212 Gene3D G3DSA:3.40.50.880 20 212 1.5E-61 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS45650 d5b9f2cf697f50c7afe5163966826eec 212 Pfam PF01965 DJ-1/PfpI family 19 189 4.8E-25 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS11950 7a79ae41fd8bc23a8740e1a181a35151 291 Pfam PF04208 Tetrahydromethanopterin S-methyltransferase, subunit A 6 137 7.4E-18 T 17-03-2017 IPR030688 Methyltransferase MtrA/MtxA KEGG: 00680+2.1.1.86 SHXM_RS37930 3b3731dff9acf7e9463083c84b68a483 307 Pfam PF00296 Luciferase-like monooxygenase 8 248 1.8E-51 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS37930 3b3731dff9acf7e9463083c84b68a483 307 TIGRFAM TIGR03560 F420_Rv1855c: probable F420-dependent oxidoreductase, Rv1855c family 2 228 5.8E-91 T 17-03-2017 IPR019952 F420-dependent oxidoreductase-predicted, Rv1855c SHXM_RS37930 3b3731dff9acf7e9463083c84b68a483 307 SUPERFAMILY SSF51679 4 306 9.16E-68 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS37930 3b3731dff9acf7e9463083c84b68a483 307 Gene3D G3DSA:3.20.20.30 8 306 2.6E-75 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS33625 d651d744aed958beca5d7f05314728e4 364 SUPERFAMILY SSF51445 55 316 1.38E-20 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS33625 d651d744aed958beca5d7f05314728e4 364 Pfam PF00704 Glycosyl hydrolases family 18 113 261 2.6E-7 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS33625 d651d744aed958beca5d7f05314728e4 364 Gene3D G3DSA:3.20.20.80 56 317 6.5E-9 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 SMART SM00490 305 405 2.3E-15 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Pfam PF04408 Helicase associated domain (HA2) 467 558 1.9E-17 T 17-03-2017 IPR007502 Helicase-associated domain GO:0004386 SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 SUPERFAMILY SSF52540 74 602 7.86E-112 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Pfam PF11898 Domain of unknown function (DUF3418) 713 1307 2.5E-233 T 17-03-2017 IPR024590 RNA helicase HrpA, C-terminal SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 SMART SM00487 72 259 5.2E-29 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 SMART SM00847 465 560 1.2E-36 T 17-03-2017 IPR007502 Helicase-associated domain GO:0004386 SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Gene3D G3DSA:3.40.50.300 275 417 1.3E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 SMART SM00382 92 385 1.9E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Pfam PF00271 Helicase conserved C-terminal domain 287 404 8.5E-10 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Gene3D G3DSA:3.40.50.300 76 233 6.2E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Pfam PF07717 Oligonucleotide/oligosaccharide-binding (OB)-fold 599 699 1.1E-15 T 17-03-2017 IPR011709 Domain of unknown function DUF1605 SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 TIGRFAM TIGR01967 DEAH_box_HrpA: RNA helicase HrpA 13 1307 0.0 T 17-03-2017 IPR010222 RNA helicase HrpA GO:0004004 SHXM_RS29450 33432c0614f2d2ea9e4ca25966d64191 1311 Pfam PF00270 DEAD/DEAH box helicase 86 233 6.8E-7 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS04125 7366ebf122dc9e83fb1c85ab13e4ca44 657 SUPERFAMILY SSF51445 175 481 3.05E-105 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04125 7366ebf122dc9e83fb1c85ab13e4ca44 657 SUPERFAMILY SSF55545 38 173 1.19E-16 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS04125 7366ebf122dc9e83fb1c85ab13e4ca44 657 SUPERFAMILY SSF140657 516 648 1.23E-5 T 17-03-2017 SHXM_RS04125 7366ebf122dc9e83fb1c85ab13e4ca44 657 Pfam PF07555 beta-N-acetylglucosaminidase 178 476 6.8E-111 T 17-03-2017 IPR011496 Beta-N-acetylglucosaminidase MetaCyc: PWY-7437 SHXM_RS04125 7366ebf122dc9e83fb1c85ab13e4ca44 657 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 38 171 1.1E-20 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS04125 7366ebf122dc9e83fb1c85ab13e4ca44 657 Gene3D G3DSA:3.30.379.10 18 171 4.2E-20 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 Gene3D G3DSA:3.40.50.2300 1 122 4.3E-39 T 17-03-2017 SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 Gene3D G3DSA:1.10.10.10 130 226 2.0E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 SMART SM00448 2 112 2.9E-41 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 Pfam PF00072 Response regulator receiver domain 4 112 8.8E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 SMART SM00862 149 225 6.4E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 SUPERFAMILY SSF52172 2 183 1.99E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS37650 782f915b87e84373bfde6e574fab39f6 227 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 225 3.6E-24 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS42565 af189194141246e2c3000dfe8fd1c1e7 452 Gene3D G3DSA:2.115.10.20 113 434 6.9E-35 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS42565 af189194141246e2c3000dfe8fd1c1e7 452 SUPERFAMILY SSF75005 96 150 6.28E-20 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS42565 af189194141246e2c3000dfe8fd1c1e7 452 SUPERFAMILY SSF75005 178 411 6.28E-20 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS42565 af189194141246e2c3000dfe8fd1c1e7 452 Pfam PF04616 Glycosyl hydrolases family 43 192 407 5.8E-14 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 Gene3D G3DSA:1.10.1900.20 56 117 3.9E-31 T 17-03-2017 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 PRINTS PR00062 Ribosomal protein L20 signature 12 41 3.4E-38 T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 PRINTS PR00062 Ribosomal protein L20 signature 42 71 3.4E-38 T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 PRINTS PR00062 Ribosomal protein L20 signature 75 101 3.4E-38 T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 TIGRFAM TIGR01032 rplT_bact: ribosomal protein bL20 2 113 1.3E-44 T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 SUPERFAMILY SSF74731 3 117 2.62E-45 T 17-03-2017 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 Hamap MF_00382 50S ribosomal protein L20 [rplT]. 2 115 27.768 T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 ProSitePatterns PS00937 Ribosomal protein L20 signature. 54 70 - T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 Pfam PF00453 Ribosomal protein L20 3 109 1.5E-44 T 17-03-2017 IPR005813 Ribosomal protein L20 GO:0003735|GO:0005622|GO:0005840|GO:0006412|GO:0019843 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13135 69c0d92d467ffd024e3485ebc3d1bb8d 127 ProDom PD002389 RIBOSOMAL RRNA-BINDING RNA-BINDING RIBONUCLEOPROTEIN L20 50S L20 CHLOROPLAST BACTERIAL ORGANELLE 21 72 2.0E-23 T 17-03-2017 SHXM_RS32445 680fcf1b435debe893b6f25df95e6a49 183 Pfam PF00994 Probable molybdopterin binding domain 13 151 7.8E-28 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32445 680fcf1b435debe893b6f25df95e6a49 183 TIGRFAM TIGR00177 molyb_syn: molybdenum cofactor synthesis domain 11 147 6.5E-31 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32445 680fcf1b435debe893b6f25df95e6a49 183 Gene3D G3DSA:3.40.980.10 10 160 1.6E-48 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32445 680fcf1b435debe893b6f25df95e6a49 183 ProSitePatterns PS01078 Molybdenum cofactor biosynthesis proteins signature 1. 70 83 - T 17-03-2017 IPR008284 Molybdenum cofactor biosynthesis, conserved site GO:0006777 Reactome: R-HSA-947581 SHXM_RS32445 680fcf1b435debe893b6f25df95e6a49 183 SMART SM00852 12 154 2.2E-24 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS32445 680fcf1b435debe893b6f25df95e6a49 183 SUPERFAMILY SSF53218 10 159 8.38E-40 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS21440 b3608766f2b1018124109d9aec06de1f 324 SUPERFAMILY SSF56349 14 311 2.94E-21 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS21440 b3608766f2b1018124109d9aec06de1f 324 Pfam PF00589 Phage integrase family 131 305 4.0E-10 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS21440 b3608766f2b1018124109d9aec06de1f 324 Gene3D G3DSA:1.10.443.10 122 311 9.3E-26 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 Gene3D G3DSA:3.40.1010.10 6 138 1.2E-36 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 254 460 2.3E-34 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 8 223 2.0E-49 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 Gene3D G3DSA:3.40.1010.10 252 365 4.2E-26 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 SUPERFAMILY SSF53790 4 245 9.03E-49 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 Gene3D G3DSA:3.30.950.10 366 476 5.1E-13 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 TIGRFAM TIGR01466 cobJ_cbiH: precorrin-3B C17-methyltransferase 254 496 1.4E-81 T 17-03-2017 IPR006363 Precorrin-3B C17-methyltransferase domain GO:0008168|GO:0009236 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 ProSitePatterns PS00839 Uroporphyrin-III C-methyltransferase signature 1. 12 26 - T 17-03-2017 IPR003043 Uroporphiryn-III C-methyltransferase, conserved site GO:0008168|GO:0055114 KEGG: 00270+2.1.1.10|KEGG: 00860+4.99.1.4+1.3.1.76+2.1.1.107|MetaCyc: PWY-5194|MetaCyc: PWY-5441|MetaCyc: PWY-702|MetaCyc: PWY-7377 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 SUPERFAMILY SSF53790 251 491 1.07E-51 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07310 f85d76beaa48c603fa9e1a9bb91fbc77 499 TIGRFAM TIGR01467 cobI_cbiL: precorrin-2 C(20)-methyltransferase 7 238 3.2E-66 T 17-03-2017 IPR006364 Precorrin-2 C(20)-methyltransferase domain GO:0008757|GO:0009236 SHXM_RS13185 5405c53981f70a1cde860cbdc5ad81dc 321 Pfam PF10708 Protein of unknown function (DUF2510) 5 40 1.6E-8 T 17-03-2017 IPR018929 Domain of unknown function DUF2510 SHXM_RS32240 52c2c69d99bf371437f60322321e5878 281 SUPERFAMILY SSF47413 10 70 6.7E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS32240 52c2c69d99bf371437f60322321e5878 281 SMART SM00530 18 73 8.6E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS32240 52c2c69d99bf371437f60322321e5878 281 Pfam PF13560 Helix-turn-helix domain 14 71 1.9E-12 T 17-03-2017 SHXM_RS32240 52c2c69d99bf371437f60322321e5878 281 Gene3D G3DSA:1.10.260.40 5 69 2.2E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 139 153 7.7E-7 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 171 185 7.7E-7 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 109 129 7.7E-7 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 PIRSF PIRSF003073 8 259 6.8E-77 T 17-03-2017 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 Pfam PF01695 IstB-like ATP binding protein 64 239 1.3E-53 T 17-03-2017 IPR002611 IstB-like ATP-binding protein GO:0005524 SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 SMART SM00382 108 241 0.0051 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 SUPERFAMILY SSF52540 103 234 3.76E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00045 68b5cc655887cba08c156a6972a0e3c6 261 Gene3D G3DSA:3.40.50.300 63 240 3.1E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42045 a440a99b7486ae9e8e4e82e46f232222 160 SUPERFAMILY SSF51182 37 142 1.63E-19 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS42045 a440a99b7486ae9e8e4e82e46f232222 160 Gene3D G3DSA:2.60.120.10 41 150 3.9E-16 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS42045 a440a99b7486ae9e8e4e82e46f232222 160 Pfam PF07883 Cupin domain 68 134 1.1E-7 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS38330 096633f44e2d7fecbbcde18236a7c171 430 Pfam PF00174 Oxidoreductase molybdopterin binding domain 291 427 1.8E-22 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS38330 096633f44e2d7fecbbcde18236a7c171 430 SUPERFAMILY SSF56524 290 425 3.53E-32 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS38330 096633f44e2d7fecbbcde18236a7c171 430 PRINTS PR00407 Eukaryotic molybdopterin domain signature 411 424 6.3E-7 T 17-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 SHXM_RS38330 096633f44e2d7fecbbcde18236a7c171 430 PRINTS PR00407 Eukaryotic molybdopterin domain signature 329 344 6.3E-7 T 17-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 SHXM_RS38330 096633f44e2d7fecbbcde18236a7c171 430 PRINTS PR00407 Eukaryotic molybdopterin domain signature 395 408 6.3E-7 T 17-03-2017 IPR008335 Eukaryotic molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-1614517 SHXM_RS38330 096633f44e2d7fecbbcde18236a7c171 430 Gene3D G3DSA:3.90.420.10 290 425 6.0E-29 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS46310 e14a00263f6dece2a6ebd012d55715bb 193 Pfam PF02627 Carboxymuconolactone decarboxylase family 36 119 4.5E-7 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS46310 e14a00263f6dece2a6ebd012d55715bb 193 Gene3D G3DSA:1.20.1290.10 26 172 6.0E-31 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS46310 e14a00263f6dece2a6ebd012d55715bb 193 SUPERFAMILY SSF69118 8 170 6.41E-33 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 Pfam PF13180 PDZ domain 136 194 3.1E-9 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 Gene3D G3DSA:2.30.42.10 142 206 7.1E-12 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 SMART SM00228 122 198 0.0086 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 Gene3D G3DSA:3.30.230.10 252 347 1.6E-21 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 255 346 1.5E-8 T 17-03-2017 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 SUPERFAMILY SSF50156 141 255 6.7E-12 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34375 0da6099969ba3abe4edd27b212dac317 364 SUPERFAMILY SSF54211 229 347 8.72E-21 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS45565 5809f5ec293fd38d589d6fb23b0a93ea 337 Gene3D G3DSA:3.40.50.720 13 104 1.7E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45565 5809f5ec293fd38d589d6fb23b0a93ea 337 Gene3D G3DSA:3.40.50.720 105 290 4.9E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45565 5809f5ec293fd38d589d6fb23b0a93ea 337 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 104 288 1.2E-45 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS45565 5809f5ec293fd38d589d6fb23b0a93ea 337 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 40 320 9.6E-9 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS45565 5809f5ec293fd38d589d6fb23b0a93ea 337 SUPERFAMILY SSF52283 9 127 9.26E-13 T 17-03-2017 SHXM_RS45565 5809f5ec293fd38d589d6fb23b0a93ea 337 SUPERFAMILY SSF51735 96 289 1.53E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 SUPERFAMILY SSF102114 2 277 6.28E-72 T 17-03-2017 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 SMART SM00729 11 213 2.9E-10 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 TIGRFAM TIGR02666 moaA: molybdenum cofactor biosynthesis protein A 2 329 6.5E-111 T 17-03-2017 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 Hamap MF_01225_B Cyclic pyranopterin monophosphate synthase [moaA]. 2 329 40.647 T 17-03-2017 IPR013483 Molybdenum cofactor biosynthesis protein A GO:0006777|GO:0046872 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 Pfam PF04055 Radical SAM superfamily 16 177 7.2E-33 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 ProSitePatterns PS01305 moaA / nifB / pqqE family signature. 17 28 - T 17-03-2017 IPR000385 MoaA/nifB/pqqE, iron-sulphur binding, conserved site GO:0003824|GO:0046872|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 Pfam PF13353 4Fe-4S single cluster domain 18 120 9.8E-7 T 17-03-2017 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 Pfam PF06463 Molybdenum Cofactor Synthesis C 183 309 4.9E-36 T 17-03-2017 IPR010505 Molybdenum cofactor synthesis C-terminal GO:0006777|GO:0019008|GO:0051539 KEGG: 00790+4.1.99.18|MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS17365 fb462bbca4f79cbb97b8bc608e30eee6 329 Gene3D G3DSA:3.20.20.70 2 305 7.0E-79 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 SUPERFAMILY SSF48498 81 195 2.62E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 40 63 1.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 19 32 1.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 63 2.2E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 Pfam PF13977 Bacterial transcriptional repressor 85 196 2.2E-14 T 17-03-2017 SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 Gene3D G3DSA:1.10.357.10 8 201 1.7E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32620 64bad7b8443ad9bc4b53adad54b10dc6 205 SUPERFAMILY SSF46689 5 84 1.49E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 SUPERFAMILY SSF54631 258 364 1.21E-11 T 17-03-2017 SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 SUPERFAMILY SSF52540 1 239 4.91E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 Pfam PF00005 ABC transporter 19 164 2.7E-34 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 Gene3D G3DSA:3.10.580.10 258 363 1.2E-10 T 17-03-2017 SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 TIGRFAM TIGR01186 proV: glycine betaine/L-proline transport ATP binding subunit 14 364 6.4E-104 T 17-03-2017 IPR005892 Glycine betaine transport ATP-binding subunit GO:0005524|GO:0016020|GO:0031460 SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 SMART SM00382 27 222 1.7E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 ProSitePatterns PS00211 ABC transporters family signature. 137 151 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS26405 c5acca12e6cea48ced8e7ea054fd711a 385 Gene3D G3DSA:3.40.50.300 1 237 6.4E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22940 1f970d5ffe9950a291d4499c435fbad1 361 Gene3D G3DSA:3.20.20.30 12 350 1.1E-90 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS22940 1f970d5ffe9950a291d4499c435fbad1 361 Pfam PF00296 Luciferase-like monooxygenase 14 327 3.5E-40 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS22940 1f970d5ffe9950a291d4499c435fbad1 361 SUPERFAMILY SSF51679 12 350 2.24E-78 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS22940 1f970d5ffe9950a291d4499c435fbad1 361 TIGRFAM TIGR03558 oxido_grp_1: luciferase family oxidoreductase, group 1 13 351 6.7E-126 T 17-03-2017 IPR019949 Luciferase family oxidoreductase, group 1 SHXM_RS50260 471b2f54068a3d8bb24097a86b561152 331 Gene3D G3DSA:3.30.420.40 176 278 3.3E-8 T 17-03-2017 SHXM_RS50260 471b2f54068a3d8bb24097a86b561152 331 SUPERFAMILY SSF53067 2 114 1.77E-5 T 17-03-2017 SHXM_RS50260 471b2f54068a3d8bb24097a86b561152 331 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 7 261 7.3E-27 T 17-03-2017 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 SHXM_RS50260 471b2f54068a3d8bb24097a86b561152 331 SUPERFAMILY SSF53067 119 302 2.85E-44 T 17-03-2017 SHXM_RS19120 e8ba0693a3bf7e6fcab45c7eb2961b44 212 Pfam PF16640 Bacterial Ig-like domain (group 3) 13 103 1.8E-22 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS19120 e8ba0693a3bf7e6fcab45c7eb2961b44 212 Pfam PF16640 Bacterial Ig-like domain (group 3) 112 203 5.6E-12 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 SMART SM00245 854 1046 1.4E-11 T 17-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Pfam PF14684 Tricorn protease C1 domain 691 758 4.7E-27 T 17-03-2017 IPR028204 Tricorn protease C1 domain SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Gene3D G3DSA:3.30.750.44 688 757 6.9E-31 T 17-03-2017 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 PIRSF PIRSF036421 8 1079 0.0 T 17-03-2017 IPR012393 Tricorn protease GO:0008236 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 SUPERFAMILY SSF50156 773 853 4.31E-11 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Pfam PF14685 Tricorn protease PDZ domain 773 861 4.0E-22 T 17-03-2017 IPR029414 Tricorn protease, PDZ domain SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Pfam PF07676 WD40-like Beta Propeller Repeat 63 84 0.026 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Pfam PF07676 WD40-like Beta Propeller Repeat 479 511 3.0E-5 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 SUPERFAMILY SSF69304 18 276 9.68E-24 T 17-03-2017 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Gene3D G3DSA:2.130.10.10 15 148 4.7E-28 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Gene3D G3DSA:2.130.10.10 357 679 3.7E-90 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Gene3D G3DSA:2.130.10.10 252 291 3.7E-90 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Pfam PF03572 Peptidase family S41 891 1044 2.0E-22 T 17-03-2017 IPR005151 Tail specific protease GO:0006508|GO:0008236 Reactome: R-HSA-2187335|Reactome: R-HSA-2453902 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 SUPERFAMILY SSF69322 306 658 1.2E-22 T 17-03-2017 SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 SUPERFAMILY SSF52096 688 767 3.98E-63 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 SUPERFAMILY SSF52096 863 1071 3.98E-63 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Gene3D G3DSA:3.90.226.10 870 1077 2.8E-38 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS32545 21520983f5ad2d9144bf5a3214db4f87 1120 Gene3D G3DSA:2.30.42.10 772 866 2.6E-25 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Pfam PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III 264 369 5.1E-26 T 17-03-2017 IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 SUPERFAMILY SSF53738 261 365 2.51E-30 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Pfam PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I 6 132 4.6E-30 T 17-03-2017 IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Gene3D G3DSA:3.40.120.10 8 131 2.1E-27 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Pfam PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 156 255 2.3E-24 T 17-03-2017 IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II GO:0005975 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 172 191 5.4E-22 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 91 105 5.4E-22 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 206 219 5.4E-22 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 PRINTS PR00509 Phosphoglucomutase/phosphomannomutase family signature 235 250 5.4E-22 T 17-03-2017 IPR005841 Alpha-D-phosphohexomutase superfamily GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Gene3D G3DSA:3.40.120.10 252 369 9.1E-38 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 SUPERFAMILY SSF53738 155 257 9.03E-30 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Pfam PF00408 Phosphoglucomutase/phosphomannomutase, C-terminal domain 374 450 2.7E-14 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Gene3D G3DSA:3.30.310.50 371 451 7.2E-22 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 Gene3D G3DSA:3.40.120.10 174 251 5.8E-31 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 SUPERFAMILY SSF53738 6 167 1.96E-31 T 17-03-2017 IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III GO:0005975|GO:0016868 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS24185 f415d4ac91e201ccacb0827b0f2d0fc7 452 SUPERFAMILY SSF55957 369 452 1.83E-20 T 17-03-2017 IPR005843 Alpha-D-phosphohexomutase, C-terminal GO:0016868|GO:0071704 KEGG: 00520+5.4.2.10|MetaCyc: PWY-6749 SHXM_RS50220 c2967cfb5aa98410c2a1b32f79442407 272 Pfam PF00296 Luciferase-like monooxygenase 22 213 4.3E-20 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50220 c2967cfb5aa98410c2a1b32f79442407 272 Gene3D G3DSA:3.20.20.30 22 136 4.1E-58 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50220 c2967cfb5aa98410c2a1b32f79442407 272 Gene3D G3DSA:3.20.20.30 177 263 4.1E-58 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50220 c2967cfb5aa98410c2a1b32f79442407 272 SUPERFAMILY SSF51679 20 263 6.54E-59 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01865 7a5c2c3620cee5da43a186d11b627eae 168 Pfam PF11706 CGNR zinc finger 118 161 1.5E-17 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS01865 7a5c2c3620cee5da43a186d11b627eae 168 SUPERFAMILY SSF160904 6 160 9.55E-31 T 17-03-2017 SHXM_RS01865 7a5c2c3620cee5da43a186d11b627eae 168 Gene3D G3DSA:1.10.3300.10 6 163 1.2E-26 T 17-03-2017 IPR023286 ABATE domain SHXM_RS27275 9fa955b3efb3b5d663e2be1646613d32 151 Gene3D G3DSA:1.10.3680.10 21 150 3.9E-23 T 17-03-2017 IPR029024 TerB-like SHXM_RS27275 9fa955b3efb3b5d663e2be1646613d32 151 Pfam PF05099 Tellurite resistance protein TerB 11 150 1.5E-32 T 17-03-2017 IPR007791 Co-chaperone DjlA, N-terminal SHXM_RS27275 9fa955b3efb3b5d663e2be1646613d32 151 SUPERFAMILY SSF158682 15 150 1.19E-24 T 17-03-2017 IPR029024 TerB-like SHXM_RS01560 4a87a6ff0d6a198bca8f443f83b1b5ee 513 Pfam PF00221 Aromatic amino acid lyase 16 473 1.8E-156 T 17-03-2017 IPR001106 Aromatic amino acid lyase Reactome: R-HSA-70921 SHXM_RS01560 4a87a6ff0d6a198bca8f443f83b1b5ee 513 Gene3D G3DSA:1.20.200.10 201 508 1.0E-101 T 17-03-2017 SHXM_RS01560 4a87a6ff0d6a198bca8f443f83b1b5ee 513 SUPERFAMILY SSF48557 8 504 3.45E-157 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS01560 4a87a6ff0d6a198bca8f443f83b1b5ee 513 Gene3D G3DSA:1.10.275.10 7 199 1.1E-59 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS17685 901fbc55c70586f70efaf0328f3bbcb6 391 Gene3D G3DSA:1.20.1250.20 3 169 1.1E-13 T 17-03-2017 SHXM_RS17685 901fbc55c70586f70efaf0328f3bbcb6 391 Gene3D G3DSA:1.20.1250.20 194 373 2.8E-11 T 17-03-2017 SHXM_RS17685 901fbc55c70586f70efaf0328f3bbcb6 391 Pfam PF07690 Major Facilitator Superfamily 3 335 1.9E-19 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS17685 901fbc55c70586f70efaf0328f3bbcb6 391 SUPERFAMILY SSF103473 2 370 6.28E-38 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36420 b380cdaa5f3a8702ee50c7ba2584a2fc 588 Pfam PF02734 DAK2 domain 35 212 7.5E-25 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS36420 b380cdaa5f3a8702ee50c7ba2584a2fc 588 SMART SM01121 260 588 1.2E-99 T 17-03-2017 IPR033470 Uncharacterised protein, DhaK domain SHXM_RS36420 b380cdaa5f3a8702ee50c7ba2584a2fc 588 Pfam PF13684 Dihydroxyacetone kinase family 262 588 4.8E-79 T 17-03-2017 IPR033470 Uncharacterised protein, DhaK domain SHXM_RS36420 b380cdaa5f3a8702ee50c7ba2584a2fc 588 SMART SM01120 35 213 1.1E-39 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS36420 b380cdaa5f3a8702ee50c7ba2584a2fc 588 TIGRFAM TIGR03599 YloV: DAK2 domain fusion protein YloV 11 588 3.0E-130 T 17-03-2017 IPR019986 DAK2 domain-containing protein YloV SHXM_RS36420 b380cdaa5f3a8702ee50c7ba2584a2fc 588 SUPERFAMILY SSF101473 5 215 1.31E-28 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 SUPERFAMILY SSF47446 331 432 6.54E-34 T 17-03-2017 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Hamap MF_00306 Signal recognition particle 54 kDa protein [srp54]. 5 447 33.268 T 17-03-2017 IPR022941 Signal recognition particle, SRP54 subunit GO:0003924|GO:0005525|GO:0006614|GO:0048500 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 SMART SM00382 99 303 2.1E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 TIGRFAM TIGR00959 ffh: signal recognition particle protein 2 431 1.9E-172 T 17-03-2017 IPR004780 Signal recognition particle protein Ffh GO:0003924|GO:0005525|GO:0006614|GO:0048500 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Gene3D G3DSA:1.10.260.30 331 433 1.1E-37 T 17-03-2017 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Pfam PF02978 Signal peptide binding domain 331 429 4.1E-31 T 17-03-2017 IPR004125 Signal recognition particle, SRP54 subunit, M-domain GO:0006614|GO:0008312|GO:0048500 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 SMART SM00963 1 86 7.5E-33 T 17-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Gene3D G3DSA:1.20.120.140 2 89 3.9E-33 T 17-03-2017 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Pfam PF00448 SRP54-type protein, GTPase domain 100 298 6.1E-68 T 17-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 SMART SM00962 100 298 2.7E-105 T 17-03-2017 IPR000897 Signal recognition particle, SRP54 subunit, GTPase domain GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Gene3D G3DSA:3.40.50.300 94 299 2.1E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 SUPERFAMILY SSF52540 42 358 4.51E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36550 9984521d64c85cf0c363b64d190bfc6c 514 Pfam PF02881 SRP54-type protein, helical bundle domain 5 82 1.3E-20 T 17-03-2017 IPR013822 Signal recognition particle, SRP54 subunit, helical bundle GO:0005525|GO:0006614 Reactome: R-HSA-1799339 SHXM_RS30730 c27b94be1a7e03ef687b7ab2516dceb1 230 Gene3D G3DSA:3.40.50.150 12 225 6.1E-47 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS30730 c27b94be1a7e03ef687b7ab2516dceb1 230 Hamap MF_01813 Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE [ubiE]. 4 229 34.145 T 17-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 SHXM_RS30730 c27b94be1a7e03ef687b7ab2516dceb1 230 SUPERFAMILY SSF53335 4 226 2.94E-45 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS30730 c27b94be1a7e03ef687b7ab2516dceb1 230 Pfam PF01209 ubiE/COQ5 methyltransferase family 11 229 8.6E-59 T 17-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 SHXM_RS30730 c27b94be1a7e03ef687b7ab2516dceb1 230 TIGRFAM TIGR01934 MenG_MenH_UbiE: ubiquinone/menaquinone biosynthesis methyltransferase 13 229 5.1E-71 T 17-03-2017 IPR004033 UbiE/COQ5 methyltransferase GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895|Reactome: R-HSA-2142789 SHXM_RS30730 c27b94be1a7e03ef687b7ab2516dceb1 230 ProSitePatterns PS01184 ubiE/COQ5 methyltransferase family signature 2. 137 151 - T 17-03-2017 IPR023576 UbiE/COQ5 methyltransferase, conserved site GO:0008168 KEGG: 00130+2.1.1.163|KEGG: 00564+2.1.1.16|MetaCyc: PWY-5839|MetaCyc: PWY-5844|MetaCyc: PWY-5849|MetaCyc: PWY-5890|MetaCyc: PWY-5891|MetaCyc: PWY-5892|MetaCyc: PWY-5895 SHXM_RS37185 e712c487db4a8388aed412e63f742add 128 Gene3D G3DSA:1.10.260.40 8 74 4.6E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS37185 e712c487db4a8388aed412e63f742add 128 SMART SM00530 11 66 4.5E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS37185 e712c487db4a8388aed412e63f742add 128 SUPERFAMILY SSF47413 3 72 1.46E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS37185 e712c487db4a8388aed412e63f742add 128 Pfam PF13560 Helix-turn-helix domain 8 65 1.5E-10 T 17-03-2017 SHXM_RS02125 a86bb1dc657abe22e651b417ab9ad70c 299 Gene3D G3DSA:3.40.50.1820 39 279 2.5E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02125 a86bb1dc657abe22e651b417ab9ad70c 299 SUPERFAMILY SSF53474 37 281 6.06E-30 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02125 a86bb1dc657abe22e651b417ab9ad70c 299 Pfam PF12697 Alpha/beta hydrolase family 47 269 1.1E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS24480 6e5fa16b39ea3460dec2deae1e8f6be9 340 SUPERFAMILY SSF52266 69 267 2.44E-29 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS24480 6e5fa16b39ea3460dec2deae1e8f6be9 340 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 74 253 1.2E-20 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS24480 6e5fa16b39ea3460dec2deae1e8f6be9 340 Gene3D G3DSA:3.40.50.1110 69 265 9.1E-24 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS22380 34f3575b325298f902218952f76571ce 386 Gene3D G3DSA:3.40.50.720 49 161 3.2E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22380 34f3575b325298f902218952f76571ce 386 SUPERFAMILY SSF51735 4 176 1.64E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22380 34f3575b325298f902218952f76571ce 386 Gene3D G3DSA:3.30.360.10 162 377 2.2E-37 T 17-03-2017 SHXM_RS22380 34f3575b325298f902218952f76571ce 386 SUPERFAMILY SSF55347 149 348 1.23E-31 T 17-03-2017 SHXM_RS22380 34f3575b325298f902218952f76571ce 386 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 58 140 5.1E-8 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS13560 8dbdb095c613fb136f8b27622a6dd4f9 98 Pfam PF03795 YCII-related domain 1 81 1.2E-10 T 17-03-2017 IPR005545 YCII-related SHXM_RS13560 8dbdb095c613fb136f8b27622a6dd4f9 98 Gene3D G3DSA:3.30.70.1060 9 81 3.1E-9 T 17-03-2017 SHXM_RS13560 8dbdb095c613fb136f8b27622a6dd4f9 98 SUPERFAMILY SSF54909 1 83 3.22E-17 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS26175 39adc444733e0793e9af91618de6701b 282 SMART SM00530 11 84 2.9E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS26175 39adc444733e0793e9af91618de6701b 282 Gene3D G3DSA:1.10.260.40 32 83 1.5E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26175 39adc444733e0793e9af91618de6701b 282 Pfam PF13560 Helix-turn-helix domain 11 85 4.3E-15 T 17-03-2017 SHXM_RS26175 39adc444733e0793e9af91618de6701b 282 SUPERFAMILY SSF47413 32 84 2.76E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22585 88b68afa41b3cee1bc30b80fe6c2db7a 297 SUPERFAMILY SSF54637 117 292 4.77E-48 T 17-03-2017 IPR029069 HotDog domain SHXM_RS22585 88b68afa41b3cee1bc30b80fe6c2db7a 297 SUPERFAMILY SSF54637 5 115 1.27E-41 T 17-03-2017 IPR029069 HotDog domain SHXM_RS22585 88b68afa41b3cee1bc30b80fe6c2db7a 297 Gene3D G3DSA:3.10.129.10 1 110 1.9E-47 T 17-03-2017 IPR029069 HotDog domain SHXM_RS22585 88b68afa41b3cee1bc30b80fe6c2db7a 297 Gene3D G3DSA:3.10.129.10 125 292 5.9E-50 T 17-03-2017 IPR029069 HotDog domain SHXM_RS22585 88b68afa41b3cee1bc30b80fe6c2db7a 297 Pfam PF13622 Thioesterase-like superfamily 34 289 9.5E-59 T 17-03-2017 SHXM_RS41635 ff80e54251042c40509517a7d4b99745 143 Gene3D G3DSA:3.40.430.10 8 140 4.1E-21 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS41635 ff80e54251042c40509517a7d4b99745 143 SUPERFAMILY SSF53597 7 141 2.75E-21 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS41635 ff80e54251042c40509517a7d4b99745 143 Pfam PF01872 RibD C-terminal domain 8 134 5.8E-17 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 Gene3D G3DSA:1.10.630.10 11 399 2.3E-108 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 SUPERFAMILY SSF48264 6 398 3.8E-86 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 Pfam PF00067 Cytochrome P450 217 368 1.1E-20 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00385 P450 superfamily signature 347 358 8.1E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00385 P450 superfamily signature 338 347 8.1E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00385 P450 superfamily signature 236 253 8.1E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00385 P450 superfamily signature 271 282 8.1E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 347 358 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 93 104 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 317 332 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 289 316 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 271 282 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 157 172 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 140 156 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 194 216 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS45335 947aa9198c9f4bf30aa8ccf6ea3bd177 400 PRINTS PR00359 B-class P450 signature 338 347 1.6E-44 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 127 239 7.6E-23 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 SUPERFAMILY SSF55874 85 241 7.33E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 Pfam PF00512 His Kinase A (phospho-acceptor) domain 20 75 1.0E-6 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 SUPERFAMILY SSF47384 17 75 5.69E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 SMART SM00387 126 241 3.7E-30 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 Gene3D G3DSA:1.10.287.130 16 67 1.4E-7 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS19935 4983e0889e4256731112ec9362b8ffbb 246 Gene3D G3DSA:3.30.565.10 68 240 1.7E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45780 5004b77efe7b9ce4ec15080774c7247a 178 SUPERFAMILY SSF54637 22 173 1.42E-6 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45780 5004b77efe7b9ce4ec15080774c7247a 178 Gene3D G3DSA:3.10.129.10 104 175 1.7E-6 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45780 5004b77efe7b9ce4ec15080774c7247a 178 Pfam PF13452 N-terminal half of MaoC dehydratase 34 160 3.7E-6 T 17-03-2017 SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 PIRSF PIRSF003073 8 259 7.9E-77 T 17-03-2017 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 Pfam PF01695 IstB-like ATP binding protein 64 239 1.9E-53 T 17-03-2017 IPR002611 IstB-like ATP-binding protein GO:0005524 SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 139 153 7.7E-7 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 171 185 7.7E-7 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 109 129 7.7E-7 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 Gene3D G3DSA:3.40.50.300 63 240 5.1E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 SMART SM00382 108 241 0.0022 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS10185 ca5982e1d9bdb235eae1631104bac7e8 261 SUPERFAMILY SSF52540 103 234 3.68E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15560 f085ebc510d914c38dae9b1985ab521b 269 Gene3D G3DSA:3.20.20.150 14 261 5.1E-35 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS15560 f085ebc510d914c38dae9b1985ab521b 269 SUPERFAMILY SSF51658 13 245 2.36E-39 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS15560 f085ebc510d914c38dae9b1985ab521b 269 Pfam PF01261 Xylose isomerase-like TIM barrel 20 222 1.0E-25 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS40600 5d5a602ba948e9a64f746154580abe0c 236 ProSitePatterns PS01081 TetR-type HTH domain signature. 58 88 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS40600 5d5a602ba948e9a64f746154580abe0c 236 Pfam PF00440 Bacterial regulatory proteins, tetR family 46 87 3.3E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS40600 5d5a602ba948e9a64f746154580abe0c 236 SUPERFAMILY SSF46689 41 102 5.99E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS40600 5d5a602ba948e9a64f746154580abe0c 236 SUPERFAMILY SSF48498 111 230 2.39E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS40600 5d5a602ba948e9a64f746154580abe0c 236 Pfam PF13977 Bacterial transcriptional repressor 113 227 3.3E-6 T 17-03-2017 SHXM_RS40600 5d5a602ba948e9a64f746154580abe0c 236 Gene3D G3DSA:1.10.357.10 42 229 3.3E-25 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 Gene3D G3DSA:3.40.50.720 4 212 9.9E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 SUPERFAMILY SSF51735 4 197 1.09E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 SUPERFAMILY SSF48179 210 308 7.99E-27 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 PIRSF PIRSF500134 3 446 5.2E-155 T 17-03-2017 IPR028357 UDP-glucose 6-dehydrogenase, bacterial type GO:0000271|GO:0003979 KEGG: 00040+1.1.1.22|KEGG: 00053+1.1.1.22|KEGG: 00500+1.1.1.22|KEGG: 00520+1.1.1.22|MetaCyc: PWY-7346 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 Pfam PF00984 UDP-glucose/GDP-mannose dehydrogenase family, central domain 210 303 9.6E-31 T 17-03-2017 IPR014026 UDP-glucose/GDP-mannose dehydrogenase, dimerisation GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 TIGRFAM TIGR03026 NDP-sugDHase: nucleotide sugar dehydrogenase 4 424 1.5E-126 T 17-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 Pfam PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain 327 428 2.9E-25 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 Gene3D G3DSA:3.40.50.720 241 444 2.6E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 Pfam PF03721 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 4 191 7.1E-58 T 17-03-2017 IPR001732 UDP-glucose/GDP-mannose dehydrogenase, N-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 Gene3D G3DSA:1.20.5.100 213 238 9.0E-17 T 17-03-2017 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 PIRSF PIRSF000124 3 443 3.8E-117 T 17-03-2017 IPR017476 UDP-glucose/GDP-mannose dehydrogenase GO:0016616|GO:0055114 Reactome: R-HSA-173599 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 SUPERFAMILY SSF52413 317 438 8.89E-34 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS24295 7a593f8f100ed2fbcaae0b2ed901922e 446 SMART SM00984 327 428 5.8E-42 T 17-03-2017 IPR014027 UDP-glucose/GDP-mannose dehydrogenase, C-terminal GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-173599 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 SMART SM00998 362 435 2.4E-14 T 17-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 Pfam PF10397 Adenylosuccinate lyase C-terminus 363 434 2.2E-12 T 17-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 Pfam PF00206 Lyase 84 299 3.0E-34 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 Gene3D G3DSA:1.10.40.30 369 435 2.5E-17 T 17-03-2017 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 Gene3D G3DSA:1.20.200.10 109 368 4.7E-104 T 17-03-2017 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 PRINTS PR00149 Fumarate lyase superfamily signature 232 259 3.8E-19 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 PRINTS PR00149 Fumarate lyase superfamily signature 106 124 3.8E-19 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 PRINTS PR00149 Fumarate lyase superfamily signature 151 169 3.8E-19 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 PRINTS PR00149 Fumarate lyase superfamily signature 274 290 3.8E-19 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 Gene3D G3DSA:1.10.275.10 22 108 5.5E-22 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 ProSitePatterns PS00163 Fumarate lyases signature. 274 283 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 SUPERFAMILY SSF48557 25 436 3.14E-86 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS20850 dce15033e051ff1c565f1bd453c6b84e 439 TIGRFAM TIGR02426 protocat_pcaB: 3-carboxy-cis,cis-muconate cycloisomerase 20 347 4.7E-118 T 17-03-2017 IPR012789 3-carboxy-cis,cis-muconate cycloisomerase GO:0019619|GO:0047472 KEGG: 00362+5.5.1.2 SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 TIGRFAM TIGR02824 quinone_pig3: putative NAD(P)H quinone oxidoreductase, PIG3 family 1 324 3.0E-142 T 17-03-2017 IPR014189 Quinone oxidoreductase PIG3 Reactome: R-HSA-6803205 SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 Gene3D G3DSA:3.90.180.10 1 146 1.4E-49 T 17-03-2017 IPR011032 GroES-like SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 87 3.1E-8 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 Pfam PF00107 Zinc-binding dehydrogenase 151 268 4.0E-29 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 SUPERFAMILY SSF50129 1 140 9.43E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 Gene3D G3DSA:3.40.50.720 147 259 8.8E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 SUPERFAMILY SSF51735 111 287 7.01E-49 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28400 4ad65e992c7e3034dadeeefbcf1b3873 325 SMART SM00829 10 323 2.6E-60 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS15340 1739b4a5a64131432792c772b2ba323d 70 Pfam PF09957 Bacterial antitoxin of type II TA system, VapB 3 44 1.4E-11 T 17-03-2017 IPR019239 Bacterial antitoxin of type II TA system, VapB SHXM_RS34955 46acbb4ad14ab4835661fa40d9e4109b 373 SUPERFAMILY SSF47240 89 318 2.8E-66 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS34955 46acbb4ad14ab4835661fa40d9e4109b 373 Gene3D G3DSA:1.10.620.20 37 279 2.9E-17 T 17-03-2017 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: R-HSA-499943 SHXM_RS34955 46acbb4ad14ab4835661fa40d9e4109b 373 Pfam PF11583 P-aminobenzoate N-oxygenase AurF 34 305 1.1E-13 T 17-03-2017 IPR025859 P-aminobenzoate N-oxygenase AurF SHXM_RS38135 99f12e23dd458924a55e3bad96fcb782 750 SUPERFAMILY SSF82866 118 342 3.79E-30 T 17-03-2017 SHXM_RS38135 99f12e23dd458924a55e3bad96fcb782 750 Pfam PF03176 MMPL family 486 706 1.6E-29 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS38135 99f12e23dd458924a55e3bad96fcb782 750 Pfam PF03176 MMPL family 49 367 6.4E-46 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS38135 99f12e23dd458924a55e3bad96fcb782 750 SUPERFAMILY SSF82866 497 704 3.27E-24 T 17-03-2017 SHXM_RS38135 99f12e23dd458924a55e3bad96fcb782 750 Gene3D G3DSA:1.20.1640.10 499 709 2.2E-28 T 17-03-2017 SHXM_RS38135 99f12e23dd458924a55e3bad96fcb782 750 Gene3D G3DSA:1.20.1640.10 157 345 1.6E-30 T 17-03-2017 SHXM_RS31045 e25aeb83480cae09df8a1d438372fe2f 156 Hamap MF_00799 UPF0336 protein . 1 149 34.064 T 17-03-2017 IPR016709 Uncharacterised protein family UPF0336 SHXM_RS31045 e25aeb83480cae09df8a1d438372fe2f 156 PIRSF PIRSF018072 1 151 3.8E-57 T 17-03-2017 IPR016709 Uncharacterised protein family UPF0336 SHXM_RS31045 e25aeb83480cae09df8a1d438372fe2f 156 SUPERFAMILY SSF54637 7 148 5.76E-38 T 17-03-2017 IPR029069 HotDog domain SHXM_RS31045 e25aeb83480cae09df8a1d438372fe2f 156 Gene3D G3DSA:3.10.129.10 1 149 2.0E-37 T 17-03-2017 IPR029069 HotDog domain SHXM_RS31045 e25aeb83480cae09df8a1d438372fe2f 156 Pfam PF13452 N-terminal half of MaoC dehydratase 7 138 4.3E-36 T 17-03-2017 SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 Gene3D G3DSA:2.140.10.10 478 825 2.1E-27 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SUPERFAMILY SSF50998 477 668 2.35E-14 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 Gene3D G3DSA:1.10.510.10 131 270 5.5E-8 T 17-03-2017 SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SUPERFAMILY SSF56112 78 272 4.25E-19 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 Pfam PF13360 PQQ-like domain 459 572 5.6E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 Pfam PF13360 PQQ-like domain 595 765 1.8E-16 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SMART SM00220 32 275 0.0046 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SUPERFAMILY SSF50998 635 789 3.01E-11 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SMART SM00564 622 651 690.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SMART SM00564 709 740 1.9E-5 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SMART SM00564 574 614 220.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SMART SM00564 492 523 1.7 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37045 bfb9ad20df37c77a738f600d5811f871 826 SMART SM00564 756 788 290.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS10930 fc68c3d7809563e0620250f97ca0c665 351 SMART SM00062 54 277 0.0011 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS10930 fc68c3d7809563e0620250f97ca0c665 351 SUPERFAMILY SSF53850 74 278 2.08E-36 T 17-03-2017 SHXM_RS10930 fc68c3d7809563e0620250f97ca0c665 351 Gene3D G3DSA:3.40.190.10 135 223 1.9E-20 T 17-03-2017 SHXM_RS10930 fc68c3d7809563e0620250f97ca0c665 351 Pfam PF09084 NMT1/THI5 like 90 219 2.6E-13 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 61 1.4E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 Gene3D G3DSA:1.10.10.10 2 81 9.7E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 SUPERFAMILY SSF53850 91 288 9.41E-28 T 17-03-2017 SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 Pfam PF03466 LysR substrate binding domain 88 288 2.0E-32 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 Gene3D G3DSA:3.40.190.10 82 210 5.4E-22 T 17-03-2017 SHXM_RS19665 3c0e5d64963dcac951a12e2229fc9786 292 SUPERFAMILY SSF46785 2 85 1.25E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 Pfam PF00163 Ribosomal protein S4/S9 N-terminal domain 3 97 2.5E-25 T 17-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 Gene3D G3DSA:3.10.290.10 101 200 1.5E-30 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 Pfam PF01479 S4 domain 99 145 1.3E-17 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 Gene3D G3DSA:1.10.1050.10 1 100 4.6E-41 T 17-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 Hamap MF_01306_B 30S ribosomal protein S4 [rpsD]. 1 208 33.287 T 17-03-2017 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 TIGRFAM TIGR01017 rpsD_bact: ribosomal protein uS4 3 208 8.5E-70 T 17-03-2017 IPR005709 Ribosomal protein S4, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 SUPERFAMILY SSF55174 3 208 4.45E-65 T 17-03-2017 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 ProSitePatterns PS00632 Ribosomal protein S4 signature. 96 120 - T 17-03-2017 IPR018079 Ribosomal protein S4, conserved site GO:0005622|GO:0019843 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6790901|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 SMART SM01390 3 97 9.8E-47 T 17-03-2017 IPR001912 Ribosomal protein S4/S9, N-terminal GO:0005622|GO:0019843 Reactome: R-HSA-6790901|Reactome: R-HSA-6791226 SHXM_RS31305 398a65847dc70f5c71282bbca55e204c 208 SMART SM00363 98 160 5.6E-16 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS48390 48eb8596a2c148d61075cf492c92d1f7 430 Pfam PF13416 Bacterial extracellular solute-binding protein 63 356 3.9E-27 T 17-03-2017 SHXM_RS48390 48eb8596a2c148d61075cf492c92d1f7 430 SUPERFAMILY SSF53850 21 428 1.02E-55 T 17-03-2017 SHXM_RS48390 48eb8596a2c148d61075cf492c92d1f7 430 Gene3D G3DSA:3.40.190.10 8 138 7.6E-12 T 17-03-2017 SHXM_RS48390 48eb8596a2c148d61075cf492c92d1f7 430 Gene3D G3DSA:3.40.190.10 323 348 7.6E-12 T 17-03-2017 SHXM_RS48390 48eb8596a2c148d61075cf492c92d1f7 430 Gene3D G3DSA:3.40.190.10 145 322 8.1E-36 T 17-03-2017 SHXM_RS39170 2023eea395eef7915613da522e122c97 713 SUPERFAMILY SSF55781 14 154 6.45E-5 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS39170 2023eea395eef7915613da522e122c97 713 SUPERFAMILY SSF55874 598 705 3.01E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39170 2023eea395eef7915613da522e122c97 713 Pfam PF13581 Histidine kinase-like ATPase domain 596 704 4.2E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39170 2023eea395eef7915613da522e122c97 713 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 395 575 4.3E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS39170 2023eea395eef7915613da522e122c97 713 SUPERFAMILY SSF55781 191 320 3.64E-7 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS39170 2023eea395eef7915613da522e122c97 713 SMART SM00331 368 575 1.8E-24 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS39170 2023eea395eef7915613da522e122c97 713 Gene3D G3DSA:3.30.450.40 192 320 2.6E-4 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS39170 2023eea395eef7915613da522e122c97 713 SUPERFAMILY SSF81606 383 575 2.88E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS11290 dc3592db63e457d174f26f38a0e22c09 624 Gene3D G3DSA:3.60.21.10 51 269 4.6E-15 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS11290 dc3592db63e457d174f26f38a0e22c09 624 SUPERFAMILY SSF49899 361 617 1.12E-24 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS11290 dc3592db63e457d174f26f38a0e22c09 624 Gene3D G3DSA:2.60.120.200 436 618 4.0E-19 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS11290 dc3592db63e457d174f26f38a0e22c09 624 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 458 616 8.1E-15 T 17-03-2017 SHXM_RS11290 dc3592db63e457d174f26f38a0e22c09 624 SUPERFAMILY SSF56300 53 278 1.52E-19 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS11290 dc3592db63e457d174f26f38a0e22c09 624 Pfam PF00149 Calcineurin-like phosphoesterase 56 223 4.1E-7 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 Pfam PF01266 FAD dependent oxidoreductase 33 394 6.8E-53 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 SUPERFAMILY SSF51905 11 79 7.45E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 SUPERFAMILY SSF51905 182 308 7.45E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 SUPERFAMILY SSF51905 111 127 7.45E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 Gene3D G3DSA:3.30.9.10 129 180 9.5E-10 T 17-03-2017 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 Gene3D G3DSA:3.30.9.10 253 352 9.5E-10 T 17-03-2017 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 Gene3D G3DSA:3.50.50.60 181 252 8.7E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 Gene3D G3DSA:3.50.50.60 356 403 8.7E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04035 55ecd8d879700179daf131b6a564f20d 459 Gene3D G3DSA:3.50.50.60 22 114 8.7E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 PRINTS PR00723 Subtilisin serine protease family (S8) signature 412 428 1.5E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 PRINTS PR00723 Subtilisin serine protease family (S8) signature 155 174 1.5E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 PRINTS PR00723 Subtilisin serine protease family (S8) signature 203 216 1.5E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 Gene3D G3DSA:3.40.50.200 127 491 1.4E-81 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 413 423 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 SUPERFAMILY SSF52743 341 491 4.71E-77 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 SUPERFAMILY SSF52743 135 314 4.71E-77 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 Pfam PF00082 Subtilase family 156 459 4.8E-49 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 207 217 - T 17-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site SHXM_RS17380 80a8267321ae11435af3493fcf428e58 492 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 160 171 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS27770 a9aad1cbe9f39b6cc75bd1972f3d4a1a 293 Pfam PF08282 haloacid dehalogenase-like hydrolase 29 287 2.4E-46 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27770 a9aad1cbe9f39b6cc75bd1972f3d4a1a 293 Gene3D G3DSA:3.40.50.1000 195 291 1.1E-44 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27770 a9aad1cbe9f39b6cc75bd1972f3d4a1a 293 Gene3D G3DSA:3.40.50.1000 24 96 1.1E-44 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27770 a9aad1cbe9f39b6cc75bd1972f3d4a1a 293 SUPERFAMILY SSF56784 26 291 2.24E-55 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27770 a9aad1cbe9f39b6cc75bd1972f3d4a1a 293 TIGRFAM TIGR00099 Cof-subfamily: Cof-like hydrolase 28 287 1.6E-40 T 17-03-2017 IPR000150 Cof protein GO:0016787 SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 Gene3D G3DSA:3.40.47.10 268 413 6.2E-50 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 SMART SM00825 Beta-ketoacyl synthase 16 414 5.8E-16 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 SUPERFAMILY SSF53901 223 412 1.61E-61 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 259 368 5.0E-31 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 Gene3D G3DSA:3.40.47.10 13 264 4.9E-48 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 SUPERFAMILY SSF53901 15 256 8.37E-48 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37745 8661deb2cba9d10cc8d4d86c60a4b5cf 416 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 15 251 5.5E-30 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS12700 7f11f1bd84680761fc7732fd2172e8f0 275 Gene3D G3DSA:3.20.10.10 126 260 2.0E-41 T 17-03-2017 SHXM_RS12700 7f11f1bd84680761fc7732fd2172e8f0 275 Gene3D G3DSA:3.30.470.10 2 103 2.4E-30 T 17-03-2017 SHXM_RS12700 7f11f1bd84680761fc7732fd2172e8f0 275 Pfam PF01063 Amino-transferase class IV 31 245 2.0E-49 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS12700 7f11f1bd84680761fc7732fd2172e8f0 275 SUPERFAMILY SSF56752 4 268 1.57E-68 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS12700 7f11f1bd84680761fc7732fd2172e8f0 275 ProSitePatterns PS00770 Aminotransferases class-IV signature. 176 205 - T 17-03-2017 IPR018300 Aminotransferase, class IV, conserved site GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS24000 5ea0666879bd98abe1b6fb6392f79701 351 Gene3D G3DSA:3.40.50.150 52 241 3.7E-37 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24000 5ea0666879bd98abe1b6fb6392f79701 351 SUPERFAMILY SSF53335 60 236 1.74E-38 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24000 5ea0666879bd98abe1b6fb6392f79701 351 Pfam PF05050 Methyltransferase FkbM domain 69 206 3.5E-17 T 17-03-2017 IPR006342 Methyltransferase FkbM SHXM_RS24000 5ea0666879bd98abe1b6fb6392f79701 351 TIGRFAM TIGR01444 fkbM_fam: methyltransferase, FkbM family 67 206 7.8E-27 T 17-03-2017 IPR006342 Methyltransferase FkbM SHXM_RS46540 e9b3f05df816f1233c74cafc05749f73 268 Pfam PF01791 DeoC/LacD family aldolase 23 234 6.1E-39 T 17-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 SHXM_RS46540 e9b3f05df816f1233c74cafc05749f73 268 SUPERFAMILY SSF51569 5 250 1.5E-58 T 17-03-2017 SHXM_RS46540 e9b3f05df816f1233c74cafc05749f73 268 PIRSF PIRSF038992 1 259 4.7E-69 T 17-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 SHXM_RS46540 e9b3f05df816f1233c74cafc05749f73 268 SMART SM01133 21 235 3.8E-36 T 17-03-2017 IPR002915 DeoC/FbaB/ lacD aldolase GO:0016829 Reactome: R-HSA-71336 SHXM_RS46540 e9b3f05df816f1233c74cafc05749f73 268 Gene3D G3DSA:3.20.20.70 4 251 1.9E-68 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 SMART SM00829 12 347 3.4E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 Pfam PF00107 Zinc-binding dehydrogenase 185 306 7.9E-21 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 Gene3D G3DSA:3.40.50.720 178 285 1.1E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 57 71 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 SUPERFAMILY SSF50129 9 181 2.43E-54 T 17-03-2017 IPR011032 GroES-like SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 Gene3D G3DSA:3.90.180.10 9 177 1.4E-57 T 17-03-2017 IPR011032 GroES-like SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 24 142 2.2E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS31670 32d6daf20a9789a66b3a9c2a81b2da75 349 SUPERFAMILY SSF51735 147 313 5.71E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07500 cb317fd0959401e75de04c727bc67877 360 SUPERFAMILY SSF50952 35 339 4.71E-40 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS07500 cb317fd0959401e75de04c727bc67877 360 Gene3D G3DSA:2.120.10.30 31 357 3.0E-84 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS07500 cb317fd0959401e75de04c727bc67877 360 Pfam PF07995 Glucose / Sorbosone dehydrogenase 52 342 1.5E-71 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS28555 9b2bc68ec321f00016b79ba32c1a2812 694 Gene3D G3DSA:2.120.10.30 680 689 1.8E-4 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS28555 9b2bc68ec321f00016b79ba32c1a2812 694 Gene3D G3DSA:2.120.10.30 558 604 1.8E-4 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS28555 9b2bc68ec321f00016b79ba32c1a2812 694 SUPERFAMILY SSF101898 420 516 3.14E-6 T 17-03-2017 SHXM_RS28555 9b2bc68ec321f00016b79ba32c1a2812 694 SUPERFAMILY SSF101898 543 551 3.14E-6 T 17-03-2017 SHXM_RS28555 9b2bc68ec321f00016b79ba32c1a2812 694 SUPERFAMILY SSF101898 583 611 3.14E-6 T 17-03-2017 SHXM_RS28555 9b2bc68ec321f00016b79ba32c1a2812 694 Pfam PF05787 Bacterial protein of unknown function (DUF839) 105 655 4.8E-173 T 17-03-2017 IPR008557 Protein of unknown function DUF839 SHXM_RS49480 7b802eceea17fc2eb77314a4e5399c70 286 ProSitePatterns PS00211 ABC transporters family signature. 181 195 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS49480 7b802eceea17fc2eb77314a4e5399c70 286 SMART SM00382 60 258 9.5E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49480 7b802eceea17fc2eb77314a4e5399c70 286 Gene3D G3DSA:3.40.50.300 45 282 2.7E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49480 7b802eceea17fc2eb77314a4e5399c70 286 PIRSF PIRSF037116 37 285 2.1E-84 T 17-03-2017 IPR012700 Phosphonate C-P lyase system, PhnK SHXM_RS49480 7b802eceea17fc2eb77314a4e5399c70 286 SUPERFAMILY SSF52540 45 281 9.82E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49480 7b802eceea17fc2eb77314a4e5399c70 286 Pfam PF00005 ABC transporter 53 208 2.2E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS13265 a1ad5927afa5e9085f5453e4db1ddebe 83 Pfam PF04149 Domain of unknown function (DUF397) 22 74 1.8E-13 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 SUPERFAMILY SSF53335 219 400 1.22E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 TIGRFAM TIGR02467 CbiE: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit 10 206 6.9E-53 T 17-03-2017 IPR012818 Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase GO:0008276|GO:0009236 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 Gene3D G3DSA:3.40.1010.10 8 112 1.2E-28 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 8 195 2.0E-24 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 Gene3D G3DSA:3.40.50.150 232 407 3.1E-19 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 PIRSF PIRSF036428 4 407 2.6E-148 T 17-03-2017 IPR006365 Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase GO:0008276|GO:0009236 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|KEGG: 00860+2.1.1.132|MetaCyc: PWY-2201|MetaCyc: PWY-3841 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 SUPERFAMILY SSF53790 8 210 6.15E-44 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 Gene3D G3DSA:3.30.950.10 113 212 3.3E-28 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS07330 66c5d9a4134dd0257e9ef160dfe32c3f 431 TIGRFAM TIGR02469 CbiT: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit 236 357 6.3E-32 T 17-03-2017 IPR014008 Cobalamin biosynthesis, precorrin-6Y methyltransferase, CbiT subunit GO:0008276|GO:0009236 KEGG: 00670+2.1.1.19|KEGG: 00860+2.1.1.196|MetaCyc: PWY-2201|MetaCyc: PWY-7377 SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 Pfam PF16859 Bacterial transcriptional repressor C-terminal 87 195 7.6E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 Pfam PF00440 Bacterial regulatory proteins, tetR family 30 75 2.7E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 SUPERFAMILY SSF46689 18 79 1.35E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 Gene3D G3DSA:1.10.357.10 68 202 1.6E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 SUPERFAMILY SSF48498 87 202 7.79E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 Gene3D G3DSA:1.10.10.60 19 66 4.3E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 42 4.3E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10880 7d9e9a58dfdab96699f4bad102cc7d29 212 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 50 73 4.3E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 52 2.7E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 8 21 2.7E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 SUPERFAMILY SSF46689 4 64 2.29E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 SUPERFAMILY SSF48498 69 196 2.89E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00400 Tetracycline repressor protein signature 20 43 3.5E-18 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00400 Tetracycline repressor protein signature 91 114 3.5E-18 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00400 Tetracycline repressor protein signature 180 194 3.5E-18 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00400 Tetracycline repressor protein signature 127 146 3.5E-18 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 PRINTS PR00400 Tetracycline repressor protein signature 71 90 3.5E-18 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 Gene3D G3DSA:1.10.357.10 66 196 2.2E-30 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 Gene3D G3DSA:1.10.10.60 2 61 3.0E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 52 3.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS07385 a1326b6d16b438368bbe4f651f006155 198 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 68 195 6.6E-17 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 Gene3D G3DSA:3.40.50.1000 89 213 5.8E-43 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 Gene3D G3DSA:3.40.50.1000 2 16 5.8E-43 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 146 166 1.6E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 128 144 1.6E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 173 186 1.6E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 2 13 1.6E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 SUPERFAMILY SSF56784 1 213 3.19E-47 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 59 183 1.8E-17 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS41595 f3676173f1a80eec9d5a987292b82355 222 Pfam PF13419 Haloacid dehalogenase-like hydrolase 5 184 5.4E-24 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS15000 24ffea75bcf0f50cb9df18c243722548 126 Pfam PF13592 Winged helix-turn helix 59 117 6.5E-15 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS15000 24ffea75bcf0f50cb9df18c243722548 126 SUPERFAMILY SSF46689 3 89 1.2E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15000 24ffea75bcf0f50cb9df18c243722548 126 Pfam PF13551 Winged helix-turn helix 1 35 6.8E-8 T 17-03-2017 SHXM_RS29575 4a3a16f25ae74b78208f962ea0f0dde8 135 ProSitePatterns PS00893 Nudix box signature. 30 51 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS29575 4a3a16f25ae74b78208f962ea0f0dde8 135 PRINTS PR00502 NUDIX hydrolase family signature 39 54 5.0E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS29575 4a3a16f25ae74b78208f962ea0f0dde8 135 PRINTS PR00502 NUDIX hydrolase family signature 25 39 5.0E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS29575 4a3a16f25ae74b78208f962ea0f0dde8 135 Pfam PF00293 NUDIX domain 2 108 8.9E-18 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS29575 4a3a16f25ae74b78208f962ea0f0dde8 135 SUPERFAMILY SSF55811 1 115 9.07E-28 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS29575 4a3a16f25ae74b78208f962ea0f0dde8 135 Gene3D G3DSA:3.90.79.10 1 111 7.3E-28 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS25755 2858f5bace48734a84a05b1ea900d222 372 SUPERFAMILY SSF81345 33 359 6.54E-65 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS25755 2858f5bace48734a84a05b1ea900d222 372 Gene3D G3DSA:1.10.3470.10 35 363 1.8E-85 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS25755 2858f5bace48734a84a05b1ea900d222 372 Pfam PF01032 FecCD transport family 50 359 9.2E-76 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS07180 55c39a7bcee19d57c7690741e94f988c 321 Gene3D G3DSA:3.90.25.10 206 303 3.8E-14 T 17-03-2017 SHXM_RS07180 55c39a7bcee19d57c7690741e94f988c 321 Gene3D G3DSA:3.40.50.720 3 205 3.0E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07180 55c39a7bcee19d57c7690741e94f988c 321 SUPERFAMILY SSF51735 3 303 2.29E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07180 55c39a7bcee19d57c7690741e94f988c 321 Pfam PF01370 NAD dependent epimerase/dehydratase family 10 235 8.1E-37 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS22250 5db5186ce01dbfc51dc7f70c07f312f3 305 PIRSF PIRSF036628 10 283 1.3E-101 T 17-03-2017 IPR024203 5-deoxy-glucuronate isomerase, IolB GO:0008880|GO:0019310 KEGG: 00562+5.3.1.30 SHXM_RS22250 5db5186ce01dbfc51dc7f70c07f312f3 305 Pfam PF04962 KduI/IolB family 12 277 9.6E-89 T 17-03-2017 IPR021120 KduI/IolB isomerase GO:0016861 KEGG: 00040+5.3.1.17|MetaCyc: PWY-6507 SHXM_RS22250 5db5186ce01dbfc51dc7f70c07f312f3 305 Gene3D G3DSA:2.60.120.10 125 284 5.7E-66 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS22250 5db5186ce01dbfc51dc7f70c07f312f3 305 TIGRFAM TIGR04378 myo_inos_iolB: 5-deoxy-glucuronate isomerase 25 278 1.8E-84 T 17-03-2017 IPR024203 5-deoxy-glucuronate isomerase, IolB GO:0008880|GO:0019310 KEGG: 00562+5.3.1.30 SHXM_RS22250 5db5186ce01dbfc51dc7f70c07f312f3 305 Gene3D G3DSA:2.60.120.10 23 124 2.3E-30 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS22250 5db5186ce01dbfc51dc7f70c07f312f3 305 SUPERFAMILY SSF51182 22 261 6.36E-61 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 SUPERFAMILY SSF63737 33 225 1.96E-36 T 17-03-2017 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 SUPERFAMILY SSF55486 236 462 7.62E-48 T 17-03-2017 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 Gene3D G3DSA:1.10.390.10 329 462 4.9E-22 T 17-03-2017 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 Pfam PF01433 Peptidase family M1 49 280 1.9E-24 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 Pfam PF01433 Peptidase family M1 311 359 2.5E-17 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 209 224 2.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 162 177 2.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 334 346 2.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS13495 a68690b4b4cd175200f6475507c4c9dc 496 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 315 330 2.5E-11 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 ProSitePatterns PS00356 LacI-type HTH domain signature. 19 37 - T 17-03-2017 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 Gene3D G3DSA:3.40.50.2300 187 323 8.9E-41 T 17-03-2017 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 SUPERFAMILY SSF53822 73 337 2.55E-62 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 Pfam PF00356 Bacterial regulatory proteins, lacI family 18 63 9.6E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 SMART SM00354 16 86 6.2E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 SUPERFAMILY SSF47413 16 74 1.66E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 Gene3D G3DSA:3.40.50.2300 67 186 4.2E-38 T 17-03-2017 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 Pfam PF13377 Periplasmic binding protein-like domain 183 342 5.3E-31 T 17-03-2017 SHXM_RS43165 9b80ce27458299fc6983d64f6ef412c6 353 Gene3D G3DSA:1.10.260.40 16 66 8.4E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 SUPERFAMILY SSF46894 142 217 7.48E-18 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 210 1.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 SMART SM00421 153 210 3.2E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 SUPERFAMILY SSF52172 2 123 4.55E-12 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 Pfam PF00072 Response regulator receiver domain 6 104 6.6E-7 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 Gene3D G3DSA:3.40.50.2300 2 128 1.5E-13 T 17-03-2017 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 Gene3D G3DSA:1.10.10.10 135 215 1.2E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 4.0E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 4.0E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32700 87b3b1890e5e8f79b5936a1487567a7c 246 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 4.0E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22010 d7db8ccebd115983ca65fb075a7f642a 166 Gene3D G3DSA:2.40.50.140 6 148 2.6E-22 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS22010 d7db8ccebd115983ca65fb075a7f642a 166 SUPERFAMILY SSF50249 5 122 3.77E-16 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS22010 d7db8ccebd115983ca65fb075a7f642a 166 Pfam PF00436 Single-strand binding protein family 6 92 2.0E-14 T 17-03-2017 IPR000424 Primosome PriB/single-strand DNA-binding GO:0003697 Reactome: R-HSA-2151201 SHXM_RS46075 75d3dc51502c90c5876adc94b0b84e2c 115 SUPERFAMILY SSF53098 11 71 2.85E-7 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS46075 75d3dc51502c90c5876adc94b0b84e2c 115 Pfam PF13683 Integrase core domain 6 69 5.7E-12 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS46075 75d3dc51502c90c5876adc94b0b84e2c 115 Gene3D G3DSA:3.30.420.10 5 69 9.3E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS43550 baa2cdb544f31998b28afea22c921a6f 142 Gene3D G3DSA:1.10.10.60 65 113 7.2E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS43550 baa2cdb544f31998b28afea22c921a6f 142 SUPERFAMILY SSF46689 62 113 4.12E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS43550 baa2cdb544f31998b28afea22c921a6f 142 Pfam PF12833 Helix-turn-helix domain 32 111 5.6E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS43550 baa2cdb544f31998b28afea22c921a6f 142 SUPERFAMILY SSF46689 11 60 1.08E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS43550 baa2cdb544f31998b28afea22c921a6f 142 SMART SM00342 26 109 1.6E-29 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS43550 baa2cdb544f31998b28afea22c921a6f 142 Gene3D G3DSA:1.10.10.60 11 64 1.6E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS23130 84f25282ccb033f79df1abc39386c1f0 83 Pfam PF00550 Phosphopantetheine attachment site 11 74 1.2E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23130 84f25282ccb033f79df1abc39386c1f0 83 SUPERFAMILY SSF47336 6 80 1.14E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23130 84f25282ccb033f79df1abc39386c1f0 83 Gene3D G3DSA:1.10.1200.10 9 79 1.0E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS29060 8b88140300bc75eb6b7416367af16701 165 SUPERFAMILY SSF53271 8 151 9.55E-26 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS29060 8b88140300bc75eb6b7416367af16701 165 Gene3D G3DSA:3.40.50.2020 8 153 3.0E-33 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS29060 8b88140300bc75eb6b7416367af16701 165 Pfam PF00156 Phosphoribosyl transferase domain 15 152 4.2E-23 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 TIGRFAM TIGR01225 hutH: histidine ammonia-lyase 6 508 1.5E-209 T 17-03-2017 IPR005921 Histidine ammonia-lyase GO:0004397|GO:0005737|GO:0006548 KEGG: 00340+4.3.1.3|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 ProSitePatterns PS00488 Phenylalanine and histidine ammonia-lyases signature. 141 157 - T 17-03-2017 IPR022313 Phenylalanine/histidine ammonia-lyases, active site GO:0016841 Reactome: R-HSA-70921 SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 SUPERFAMILY SSF48557 6 506 2.59E-176 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 Hamap MF_00229 Histidine ammonia-lyase [hutH]. 5 508 43.243 T 17-03-2017 IPR005921 Histidine ammonia-lyase GO:0004397|GO:0005737|GO:0006548 KEGG: 00340+4.3.1.3|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 Pfam PF00221 Aromatic amino acid lyase 14 473 3.2E-181 T 17-03-2017 IPR001106 Aromatic amino acid lyase Reactome: R-HSA-70921 SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 Gene3D G3DSA:1.10.275.10 3 200 3.3E-71 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS24650 4e9eaaf89cccee7e3f8681c1daa21cc2 514 Gene3D G3DSA:1.20.200.10 201 510 1.6E-115 T 17-03-2017 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 SUPERFAMILY SSF47413 30 76 3.87E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 Pfam PF00356 Bacterial regulatory proteins, lacI family 32 76 7.9E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 SMART SM00354 30 93 1.0E-10 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 Gene3D G3DSA:3.40.50.2300 101 193 1.3E-8 T 17-03-2017 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 ProSitePatterns PS00356 LacI-type HTH domain signature. 33 51 - T 17-03-2017 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 Gene3D G3DSA:3.40.50.2300 194 349 3.7E-29 T 17-03-2017 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 Gene3D G3DSA:1.10.260.40 30 76 1.2E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 SUPERFAMILY SSF53822 102 343 1.01E-32 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS13870 ce398cc98cc5a4f6fe49ef5a5985d731 358 Pfam PF13377 Periplasmic binding protein-like domain 193 349 3.5E-28 T 17-03-2017 SHXM_RS35450 fb5b8727b80725038453148d33998cab 212 SUPERFAMILY SSF51219 8 208 6.28E-45 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS35450 fb5b8727b80725038453148d33998cab 212 Gene3D G3DSA:3.60.160.10 7 207 4.3E-43 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS35450 fb5b8727b80725038453148d33998cab 212 Pfam PF01987 Mitochondrial biogenesis AIM24 8 202 6.2E-34 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS46270 23246951a8d66b7a0f38603919c57b14 601 PIRSF PIRSF036654 44 599 1.1E-283 T 17-03-2017 IPR014614 Uncharacterised conserved protein UCP036654 GO:0016627|GO:0055114 SHXM_RS46270 23246951a8d66b7a0f38603919c57b14 601 Gene3D G3DSA:3.50.50.60 533 597 2.2E-67 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46270 23246951a8d66b7a0f38603919c57b14 601 Gene3D G3DSA:3.50.50.60 46 324 2.2E-67 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46270 23246951a8d66b7a0f38603919c57b14 601 Pfam PF00890 FAD binding domain 50 581 4.3E-107 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS46270 23246951a8d66b7a0f38603919c57b14 601 SUPERFAMILY SSF51905 536 597 7.41E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46270 23246951a8d66b7a0f38603919c57b14 601 SUPERFAMILY SSF51905 44 329 7.41E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42145 3330055946481c804fd42e5a1fc3dfb6 347 Pfam PF02653 Branched-chain amino acid transport system / permease component 66 335 5.7E-46 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS07125 b10f8125e4c1ec518ac65bdaf3f90ee9 70 SUPERFAMILY SSF89807 3 67 3.66E-26 T 17-03-2017 IPR009923 Dodecin SHXM_RS07125 b10f8125e4c1ec518ac65bdaf3f90ee9 70 Pfam PF07311 Dodecin 4 67 6.2E-31 T 17-03-2017 IPR009923 Dodecin SHXM_RS07125 b10f8125e4c1ec518ac65bdaf3f90ee9 70 Gene3D G3DSA:3.30.1660.10 2 68 4.8E-36 T 17-03-2017 IPR025543 Dodecin-like SHXM_RS36920 407ea44f8cdf73bdb9334490a5f356e5 95 SUPERFAMILY SSF64376 10 89 4.05E-22 T 17-03-2017 IPR007393 Domain of unknown function DUF448 SHXM_RS36920 407ea44f8cdf73bdb9334490a5f356e5 95 Gene3D G3DSA:3.30.1230.10 9 88 7.5E-25 T 17-03-2017 IPR007393 Domain of unknown function DUF448 SHXM_RS36920 407ea44f8cdf73bdb9334490a5f356e5 95 Pfam PF04296 Protein of unknown function (DUF448) 13 74 1.7E-21 T 17-03-2017 IPR007393 Domain of unknown function DUF448 SHXM_RS45950 1d7bf9c852e4006509f917f3a774ca98 278 Pfam PF02673 Bacitracin resistance protein BacA 9 265 3.2E-72 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS45950 1d7bf9c852e4006509f917f3a774ca98 278 TIGRFAM TIGR00753 undec_PP_bacA: undecaprenyl-diphosphatase UppP 9 264 3.0E-73 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS45950 1d7bf9c852e4006509f917f3a774ca98 278 Hamap MF_01006 Undecaprenyl-diphosphatase [uppP]. 4 271 17.626 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS00815 b20d75e2da186608b64093ec7d051f1b 166 Gene3D G3DSA:3.40.630.30 8 145 9.9E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS00815 b20d75e2da186608b64093ec7d051f1b 166 Pfam PF00583 Acetyltransferase (GNAT) family 70 140 1.5E-11 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS00815 b20d75e2da186608b64093ec7d051f1b 166 SUPERFAMILY SSF55729 13 146 8.54E-24 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS47755 ba86d02dc46432db52808df3bd6fae48 79 Gene3D G3DSA:3.40.1650.10 3 34 3.2E-10 T 17-03-2017 IPR023750 RbsD-like domain GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 SHXM_RS47755 ba86d02dc46432db52808df3bd6fae48 79 SUPERFAMILY SSF102546 3 38 4.58E-10 T 17-03-2017 IPR023750 RbsD-like domain GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 SHXM_RS47755 ba86d02dc46432db52808df3bd6fae48 79 Pfam PF05025 RbsD / FucU transport protein family 5 34 4.1E-8 T 17-03-2017 IPR007721 D-ribose pyranase RbsD/L-fucose mutarotase FucU GO:0005996|GO:0016853|GO:0048029 Reactome: R-HSA-6787639 SHXM_RS42105 ede18a35ad2850ac6e9e328d8a6eb322 401 Gene3D G3DSA:1.20.1250.20 5 186 3.4E-27 T 17-03-2017 SHXM_RS42105 ede18a35ad2850ac6e9e328d8a6eb322 401 Pfam PF07690 Major Facilitator Superfamily 8 321 1.7E-41 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS42105 ede18a35ad2850ac6e9e328d8a6eb322 401 SUPERFAMILY SSF103473 3 375 1.24E-58 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS42105 ede18a35ad2850ac6e9e328d8a6eb322 401 Gene3D G3DSA:1.20.1250.20 197 375 8.6E-14 T 17-03-2017 SHXM_RS18735 27d115eb3feaaba69df67605f8d28c0a 95 Pfam PF04324 BFD-like [2Fe-2S] binding domain 2 50 5.4E-11 T 17-03-2017 IPR007419 BFD-like [2Fe-2S]-binding domain SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 Pfam PF09261 Alpha mannosidase middle domain 521 599 2.8E-28 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 SMART SM00872 521 599 2.1E-40 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 SUPERFAMILY SSF74650 686 1030 3.77E-59 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 Gene3D G3DSA:1.20.1270.50 524 618 1.0E-25 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 676 1026 6.8E-59 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 SUPERFAMILY SSF88713 249 519 2.54E-77 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 255 514 4.1E-85 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 SUPERFAMILY SSF88688 520 619 3.6E-28 T 17-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain SHXM_RS01475 d235d5674f96e159f13d614d9cb930aa 1037 Gene3D G3DSA:3.20.110.10 206 523 8.9E-90 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS45405 a671c32413f29ab875f8b41b791d656a 126 Gene3D G3DSA:1.10.10.10 10 125 4.0E-39 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45405 a671c32413f29ab875f8b41b791d656a 126 Pfam PF01638 HxlR-like helix-turn-helix 29 116 1.9E-29 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS45405 a671c32413f29ab875f8b41b791d656a 126 SUPERFAMILY SSF46785 23 124 7.4E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 SUPERFAMILY SSF55781 78 265 4.61E-26 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 SUPERFAMILY SSF55781 388 567 1.13E-45 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Pfam PF01614 Bacterial transcriptional regulator 190 254 9.0E-8 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Pfam PF01614 Bacterial transcriptional regulator 439 565 7.7E-31 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Gene3D G3DSA:1.10.10.10 7 81 3.0E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Gene3D G3DSA:1.10.10.10 306 391 3.6E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 SMART SM00346 309 412 4.3E-17 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 SMART SM00346 9 102 9.2E-6 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Gene3D G3DSA:3.30.450.40 392 568 2.3E-53 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Gene3D G3DSA:3.30.450.40 82 266 2.8E-48 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 SUPERFAMILY SSF46785 339 394 1.79E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 SUPERFAMILY SSF46785 11 84 2.31E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Pfam PF09339 IclR helix-turn-helix domain 311 377 2.0E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38280 106cbc792441a26635d64c50cdab29b3 584 Pfam PF09339 IclR helix-turn-helix domain 12 67 1.2E-7 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 Gene3D G3DSA:3.40.50.740 277 486 1.8E-92 T 17-03-2017 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 Gene3D G3DSA:3.40.50.740 16 93 1.8E-92 T 17-03-2017 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 Gene3D G3DSA:2.40.40.20 523 642 7.8E-30 T 17-03-2017 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 Pfam PF01568 Molydopterin dinucleotide binding domain 532 634 9.9E-25 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 SUPERFAMILY SSF50692 521 642 2.03E-30 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 Gene3D G3DSA:3.40.228.10 94 276 5.0E-63 T 17-03-2017 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 SUPERFAMILY SSF53706 13 488 1.24E-170 T 17-03-2017 SHXM_RS14235 ebb648fc371dc934c446cf8e9818e0c5 649 Pfam PF00384 Molybdopterin oxidoreductase 16 441 1.3E-82 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 PRINTS PR00598 Bacterial regulatory protein MarR family signature 64 80 8.1E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 PRINTS PR00598 Bacterial regulatory protein MarR family signature 131 151 8.1E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 PRINTS PR00598 Bacterial regulatory protein MarR family signature 81 96 8.1E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 PRINTS PR00598 Bacterial regulatory protein MarR family signature 100 116 8.1E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 Pfam PF12802 MarR family 44 104 1.1E-11 T 17-03-2017 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 Gene3D G3DSA:1.10.10.10 7 157 1.3E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 SMART SM00347 38 141 7.9E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32330 1d0edd9fc77e3d9b0a985d265f579746 166 SUPERFAMILY SSF46785 9 156 4.06E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29385 8f91f449a01334361578a940963e413d 94 Hamap MF_01926 Phosphoribosylformylglycinamidine synthase subunit PurS [purS]. 2 79 21.959 T 17-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29385 8f91f449a01334361578a940963e413d 94 Pfam PF02700 Phosphoribosylformylglycinamidine (FGAM) synthase 4 79 3.1E-28 T 17-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29385 8f91f449a01334361578a940963e413d 94 TIGRFAM TIGR00302 TIGR00302: phosphoribosylformylglycinamidine synthase, purS protein 4 80 1.2E-20 T 17-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29385 8f91f449a01334361578a940963e413d 94 ProDom PD010362 PHOSPHORIBOSYLFORMYLGLYCINAMIDINE PURS SYNTHETASE SYNTHASE COMPONENT SYNTHASE LIGASE FGAM UPF0062 I 10 80 2.0E-32 T 17-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29385 8f91f449a01334361578a940963e413d 94 SUPERFAMILY SSF82697 3 78 4.19E-25 T 17-03-2017 SHXM_RS29385 8f91f449a01334361578a940963e413d 94 Gene3D G3DSA:3.30.1280.10 3 80 7.4E-33 T 17-03-2017 IPR003850 Phosphoribosylformylglycinamidine synthase subunit PurS KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS22240 eda8bcdb76f709f69ccf8258bbb62ccd 501 Gene3D G3DSA:3.40.605.10 2 260 1.9E-90 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS22240 eda8bcdb76f709f69ccf8258bbb62ccd 501 SUPERFAMILY SSF53720 2 485 1.17E-147 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS22240 eda8bcdb76f709f69ccf8258bbb62ccd 501 Pfam PF00171 Aldehyde dehydrogenase family 21 480 3.1E-138 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS22240 eda8bcdb76f709f69ccf8258bbb62ccd 501 TIGRFAM TIGR01722 MMSDH: methylmalonate-semialdehyde dehydrogenase (acylating) 4 484 2.7E-236 T 17-03-2017 IPR010061 Methylmalonate-semialdehyde dehydrogenase GO:0004491|GO:0055114 KEGG: 00280+1.2.1.27|KEGG: 00410+1.2.1.18|KEGG: 00562+1.2.1.18|KEGG: 00640+1.2.1.18+1.2.1.27|MetaCyc: PWY-5642|MetaCyc: PWY-6373|Reactome: R-HSA-70895 SHXM_RS22240 eda8bcdb76f709f69ccf8258bbb62ccd 501 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 274 285 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS22240 eda8bcdb76f709f69ccf8258bbb62ccd 501 Gene3D G3DSA:3.40.309.10 261 453 1.7E-62 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS46140 d36a6d78094c1028259bc0f6dec9be3f 628 SUPERFAMILY SSF75005 400 616 9.42E-25 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46140 d36a6d78094c1028259bc0f6dec9be3f 628 Gene3D G3DSA:2.115.10.20 403 607 9.9E-19 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46140 d36a6d78094c1028259bc0f6dec9be3f 628 Gene3D G3DSA:2.115.10.20 43 355 1.0E-99 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46140 d36a6d78094c1028259bc0f6dec9be3f 628 SUPERFAMILY SSF75005 41 348 5.23E-67 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46140 d36a6d78094c1028259bc0f6dec9be3f 628 Pfam PF04616 Glycosyl hydrolases family 43 48 347 6.7E-70 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS46140 d36a6d78094c1028259bc0f6dec9be3f 628 Pfam PF04616 Glycosyl hydrolases family 43 404 594 2.4E-10 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS18610 9f5aac9061ac25a7c70f54c2ee3a3406 184 Gene3D G3DSA:3.40.1050.10 23 181 3.1E-33 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS18610 9f5aac9061ac25a7c70f54c2ee3a3406 184 Pfam PF00484 Carbonic anhydrase 51 130 3.3E-11 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS18610 9f5aac9061ac25a7c70f54c2ee3a3406 184 SMART SM00947 43 181 1.8E-22 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS18610 9f5aac9061ac25a7c70f54c2ee3a3406 184 SUPERFAMILY SSF53056 14 181 4.84E-35 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS40740 5adf562de480c96b83a709764ad4e0e7 278 Pfam PF00106 short chain dehydrogenase 10 201 6.8E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40740 5adf562de480c96b83a709764ad4e0e7 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 4.5E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40740 5adf562de480c96b83a709764ad4e0e7 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 4.5E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40740 5adf562de480c96b83a709764ad4e0e7 278 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 4.5E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40740 5adf562de480c96b83a709764ad4e0e7 278 Gene3D G3DSA:3.40.50.720 4 237 1.7E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40740 5adf562de480c96b83a709764ad4e0e7 278 SUPERFAMILY SSF51735 6 267 1.82E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35885 167c6cadd0f0ea9ddd8e1b8ade70aa89 222 SMART SM00641 2 101 1.5E-22 T 17-03-2017 IPR018077 Glycoside hydrolase, family 25 subgroup SHXM_RS35885 167c6cadd0f0ea9ddd8e1b8ade70aa89 222 SUPERFAMILY SSF51445 3 174 1.75E-36 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35885 167c6cadd0f0ea9ddd8e1b8ade70aa89 222 Pfam PF01183 Glycosyl hydrolases family 25 5 164 1.4E-40 T 17-03-2017 IPR002053 Glycoside hydrolase, family 25 GO:0003796|GO:0009253|GO:0016998 SHXM_RS35885 167c6cadd0f0ea9ddd8e1b8ade70aa89 222 Gene3D G3DSA:3.20.20.80 2 174 2.8E-41 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS48770 66d1c840020948c3ab3d1fa88b95afc7 273 PIRSF PIRSF006648 2 272 1.4E-61 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS48770 66d1c840020948c3ab3d1fa88b95afc7 273 Pfam PF01061 ABC-2 type transporter 20 226 4.5E-28 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 3.8E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 3.8E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 1.0E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 SUPERFAMILY SSF48498 88 194 6.3E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 Gene3D G3DSA:1.10.357.10 9 193 5.1E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 SUPERFAMILY SSF46689 7 75 3.39E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS12750 ee332e3b187c9de27da54e46fbb380ed 195 ProSitePatterns PS01081 TetR-type HTH domain signature. 23 53 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS33395 1d3db3d304a90238e7378e702a987275 916 Gene3D G3DSA:2.130.10.10 261 409 2.0E-14 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS33395 1d3db3d304a90238e7378e702a987275 916 Gene3D G3DSA:2.130.10.10 84 247 2.1E-17 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS33395 1d3db3d304a90238e7378e702a987275 916 Pfam PF04185 Phosphoesterase family 510 777 3.9E-5 T 17-03-2017 IPR007312 Phosphoesterase GO:0016788 SHXM_RS33395 1d3db3d304a90238e7378e702a987275 916 SUPERFAMILY SSF51004 83 412 1.12E-26 T 17-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SHXM_RS02385 702f997f220ef311298d26a5bb411a0a 292 SUPERFAMILY SSF161098 83 270 1.7E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02385 702f997f220ef311298d26a5bb411a0a 292 Gene3D G3DSA:1.10.3720.10 78 286 6.7E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02385 702f997f220ef311298d26a5bb411a0a 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 289 6.8E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 Gene3D G3DSA:3.40.109.30 89 175 1.8E-11 T 17-03-2017 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 SUPERFAMILY SSF55469 313 404 1.31E-9 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 SUPERFAMILY SSF55469 199 260 1.31E-9 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 Pfam PF08940 Domain of unknown function (DUF1918) 3 60 7.0E-26 T 17-03-2017 IPR015035 Domain of unknown function DUF1918 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 SUPERFAMILY SSF50118 3 69 4.84E-22 T 17-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 Gene3D G3DSA:3.40.109.10 318 410 2.2E-15 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 Gene3D G3DSA:3.40.109.10 195 272 2.2E-15 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 SUPERFAMILY SSF55469 82 171 4.71E-10 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43020 e0a28fc4b48cc5f0fc1d61c707968a28 412 Pfam PF00881 Nitroreductase family 203 392 1.4E-7 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS02965 1afd8836a012bc2c7727b4f66cc830f6 328 Gene3D G3DSA:2.40.100.10 180 292 1.2E-4 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS02965 1afd8836a012bc2c7727b4f66cc830f6 328 SUPERFAMILY SSF50891 180 294 8.34E-7 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS02965 1afd8836a012bc2c7727b4f66cc830f6 328 SMART SM00797 25 306 1.0E-63 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS02965 1afd8836a012bc2c7727b4f66cc830f6 328 Pfam PF02626 Allophanate hydrolase subunit 2 26 288 7.6E-62 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS32625 0eccda824dbef343405caa9618609db4 125 Pfam PF07045 Domain of unknown function (DUF1330) 35 110 1.4E-7 T 17-03-2017 IPR010753 Domain of unknown function DUF1330 SHXM_RS32625 0eccda824dbef343405caa9618609db4 125 Gene3D G3DSA:3.30.70.900 2 121 1.0E-36 T 17-03-2017 SHXM_RS32625 0eccda824dbef343405caa9618609db4 125 SUPERFAMILY SSF54909 34 111 3.0E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 4.9E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 4.9E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 4.9E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 SUPERFAMILY SSF53850 88 301 2.05E-30 T 17-03-2017 SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 SUPERFAMILY SSF46785 1 83 1.09E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 4.8E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 Gene3D G3DSA:1.10.10.10 1 83 4.7E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 Pfam PF03466 LysR substrate binding domain 87 298 5.9E-31 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 Gene3D G3DSA:3.40.190.10 178 266 1.5E-12 T 17-03-2017 SHXM_RS13520 ad5c20bdda21ad58b9aa679ff411e311 312 Gene3D G3DSA:3.40.190.10 88 177 1.7E-25 T 17-03-2017 SHXM_RS17905 da87a653b87177a9110ddf4fdb9660f8 111 Hamap MF_01483 RNA polymerase-binding protein RbpA [rbpA]. 17 110 23.781 T 17-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 SHXM_RS17905 da87a653b87177a9110ddf4fdb9660f8 111 Pfam PF13397 RNA polymerase-binding protein 5 108 1.0E-42 T 17-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 SHXM_RS17905 da87a653b87177a9110ddf4fdb9660f8 111 ProSitePatterns PS00202 Rubredoxin signature. 51 61 - T 17-03-2017 IPR018527 Rubredoxin, iron-binding site GO:0046872 SHXM_RS06515 087650cbb4fe2a0fe2eeac775b4d73ab 486 Pfam PF00171 Aldehyde dehydrogenase family 18 475 2.1E-154 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS06515 087650cbb4fe2a0fe2eeac775b4d73ab 486 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS06515 087650cbb4fe2a0fe2eeac775b4d73ab 486 Gene3D G3DSA:3.40.309.10 267 450 8.4E-65 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS06515 087650cbb4fe2a0fe2eeac775b4d73ab 486 SUPERFAMILY SSF53720 2 476 1.44E-148 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS06515 087650cbb4fe2a0fe2eeac775b4d73ab 486 Gene3D G3DSA:3.40.605.10 3 266 1.9E-81 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS35820 2f5ea0c009aadcab688279d8f39161e4 320 Pfam PF06675 Protein of unknown function (DUF1177) 47 315 1.8E-129 T 17-03-2017 IPR009561 Protein of unknown function DUF1177 SHXM_RS30075 898fde87a7a0ce567c0850271cfe4758 121 Pfam PF02635 DsrE/DsrF-like family 3 108 1.7E-11 T 17-03-2017 IPR003787 Sulphur relay, DsrE/F-like protein SHXM_RS30075 898fde87a7a0ce567c0850271cfe4758 121 SUPERFAMILY SSF75169 3 112 1.06E-19 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS30075 898fde87a7a0ce567c0850271cfe4758 121 Gene3D G3DSA:3.40.1260.10 3 111 8.5E-18 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS21920 a04fa42394847dbf6d824f50cefe48ac 317 SUPERFAMILY SSF161098 62 302 2.88E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS21920 a04fa42394847dbf6d824f50cefe48ac 317 Gene3D G3DSA:1.10.3720.10 11 306 2.9E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS21920 a04fa42394847dbf6d824f50cefe48ac 317 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 297 4.1E-8 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02830 4d4ffbb0633e3154f120c0e5725a823e 266 Gene3D G3DSA:2.60.120.200 44 266 9.5E-60 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS02830 4d4ffbb0633e3154f120c0e5725a823e 266 SUPERFAMILY SSF49899 46 266 2.61E-55 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS02830 4d4ffbb0633e3154f120c0e5725a823e 266 Pfam PF08787 Alginate lyase 56 265 1.7E-36 T 17-03-2017 IPR014895 Alginate lyase 2 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 23 126 5.1E-15 T 17-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 Gene3D G3DSA:3.40.50.720 148 334 1.8E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 SUPERFAMILY SSF53223 5 142 4.16E-28 T 17-03-2017 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 175 195 6.0E-13 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 61 75 6.0E-13 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 131 153 6.0E-13 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 284 295 6.0E-13 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 SUPERFAMILY SSF51735 148 341 2.62E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 Gene3D G3DSA:3.40.192.10 4 147 7.5E-40 T 17-03-2017 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 SMART SM00839 144 350 1.5E-33 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 221 292 4.2E-8 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS10540 f23692cd6e7fa5f626d51c19e962bdb1 352 PIRSF PIRSF000188 1 352 8.2E-97 T 17-03-2017 IPR016211 Glutamate/phenylalanine/leucine/valine dehydrogenase, bacterial/archaeal GO:0016639|GO:0055114 SHXM_RS49030 228d713c7b3ef83401d8fbe67d31b097 353 Pfam PF00296 Luciferase-like monooxygenase 33 285 3.0E-54 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS49030 228d713c7b3ef83401d8fbe67d31b097 353 Gene3D G3DSA:3.20.20.30 19 345 1.0E-86 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS49030 228d713c7b3ef83401d8fbe67d31b097 353 SUPERFAMILY SSF51679 93 345 9.42E-76 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS49030 228d713c7b3ef83401d8fbe67d31b097 353 SUPERFAMILY SSF51679 31 60 9.42E-76 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS49030 228d713c7b3ef83401d8fbe67d31b097 353 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 40 323 3.5E-56 T 17-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted SHXM_RS03770 53a1a2641ed47b2bcaa00dc0d27eca76 335 SUPERFAMILY SSF52540 3 39 6.83E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03770 53a1a2641ed47b2bcaa00dc0d27eca76 335 SUPERFAMILY SSF52540 145 293 6.83E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03770 53a1a2641ed47b2bcaa00dc0d27eca76 335 Gene3D G3DSA:3.40.50.300 5 53 1.7E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03770 53a1a2641ed47b2bcaa00dc0d27eca76 335 Gene3D G3DSA:3.40.50.300 131 290 1.7E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03770 53a1a2641ed47b2bcaa00dc0d27eca76 335 Pfam PF13469 Sulfotransferase family 5 285 1.0E-16 T 17-03-2017 SHXM_RS50345 f56bc090b48f0d64b0d372e70f56cef3 444 PIRSF PIRSF000337 1 441 4.3E-163 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS50345 f56bc090b48f0d64b0d372e70f56cef3 444 SUPERFAMILY SSF51679 1 432 1.96E-125 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50345 f56bc090b48f0d64b0d372e70f56cef3 444 Pfam PF00296 Luciferase-like monooxygenase 10 378 4.0E-60 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50345 f56bc090b48f0d64b0d372e70f56cef3 444 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 3 426 1.0E-161 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS50345 f56bc090b48f0d64b0d372e70f56cef3 444 Gene3D G3DSA:3.20.20.30 1 308 3.3E-128 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50345 f56bc090b48f0d64b0d372e70f56cef3 444 Gene3D G3DSA:3.20.20.30 345 433 3.3E-128 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42200 e0501b07e59089e5d48e6cadc2f56fc3 305 SUPERFAMILY SSF46689 10 81 2.51E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42200 e0501b07e59089e5d48e6cadc2f56fc3 305 Pfam PF01418 Helix-turn-helix domain, rpiR family 10 81 1.6E-13 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS42200 e0501b07e59089e5d48e6cadc2f56fc3 305 Gene3D G3DSA:3.40.50.10490 113 276 1.4E-31 T 17-03-2017 SHXM_RS42200 e0501b07e59089e5d48e6cadc2f56fc3 305 SUPERFAMILY SSF53697 114 289 2.22E-35 T 17-03-2017 SHXM_RS42200 e0501b07e59089e5d48e6cadc2f56fc3 305 Gene3D G3DSA:1.10.10.10 9 81 1.4E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42200 e0501b07e59089e5d48e6cadc2f56fc3 305 Pfam PF01380 SIS domain 140 243 3.4E-14 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 SUPERFAMILY SSF54631 212 347 8.97E-27 T 17-03-2017 SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 Pfam PF01595 Domain of unknown function DUF21 8 201 3.2E-31 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 SMART SM01091 352 429 3.1E-23 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 Gene3D G3DSA:3.30.465.10 344 426 1.7E-24 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 Pfam PF00571 CBS domain 283 336 1.8E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 Pfam PF00571 CBS domain 219 273 6.3E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 SUPERFAMILY SSF56176 351 434 4.09E-19 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 Pfam PF03471 Transporter associated domain 354 427 1.9E-19 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS28835 da06bf7ac720a802bf4fdfc2638ab0a9 460 Gene3D G3DSA:3.10.580.10 209 343 1.3E-18 T 17-03-2017 SHXM_RS26830 a9b338fa65cd2a618676ccb2fe03afa0 65 Pfam PF12728 Helix-turn-helix domain 12 59 8.1E-15 T 17-03-2017 SHXM_RS26830 a9b338fa65cd2a618676ccb2fe03afa0 65 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 12 59 2.5E-15 T 17-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 SHXM_RS26830 a9b338fa65cd2a618676ccb2fe03afa0 65 SUPERFAMILY SSF46955 12 60 4.76E-5 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS25415 20f5c46fb232df7c63123806862bcb6c 203 Gene3D G3DSA:3.90.1570.10 21 174 1.5E-15 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS25415 20f5c46fb232df7c63123806862bcb6c 203 Pfam PF05685 Putative restriction endonuclease 29 186 6.8E-25 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS25415 20f5c46fb232df7c63123806862bcb6c 203 SUPERFAMILY SSF52980 21 181 4.56E-16 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS30445 f01aa746ab5049522652cfa1ff558c5a 307 TIGRFAM TIGR01490 HAD-SF-IB-hyp1: HAD hydrolase, family IB 56 257 3.0E-52 T 17-03-2017 IPR006385 HAD-superfamily hydrolase, subfamily IB, PSPase-like, bacterial SHXM_RS30445 f01aa746ab5049522652cfa1ff558c5a 307 SUPERFAMILY SSF56784 55 265 1.6E-29 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS30445 f01aa746ab5049522652cfa1ff558c5a 307 Pfam PF12710 haloacid dehalogenase-like hydrolase 57 243 1.4E-27 T 17-03-2017 SHXM_RS30445 f01aa746ab5049522652cfa1ff558c5a 307 Gene3D G3DSA:3.40.50.1000 129 273 2.5E-48 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS30445 f01aa746ab5049522652cfa1ff558c5a 307 TIGRFAM TIGR01488 HAD-SF-IB: HAD phosphoserine phosphatase-like hydrolase, family IB 56 245 1.4E-15 T 17-03-2017 IPR006383 HAD-superfamily hydrolase, subfamily IB, PSPase-like GO:0008152|GO:0016791 SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 Gene3D G3DSA:1.10.10.10 10 74 1.0E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 Gene3D G3DSA:3.30.420.40 77 219 1.9E-42 T 17-03-2017 SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 SUPERFAMILY SSF46785 12 71 2.03E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 Pfam PF00480 ROK family 82 378 2.6E-59 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 ProSitePatterns PS01125 ROK family signature. 215 242 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 SUPERFAMILY SSF53067 79 383 2.59E-57 T 17-03-2017 SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 Gene3D G3DSA:3.30.420.40 220 360 3.3E-47 T 17-03-2017 SHXM_RS38185 b3cd89c275aa79ef12476504ea4ea9c7 399 Pfam PF12802 MarR family 17 68 2.4E-8 T 17-03-2017 SHXM_RS34310 0ac23dfce2d236248657958545bd263f 120 Pfam PF02467 Transcription factor WhiB 47 95 4.0E-15 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS34310 0ac23dfce2d236248657958545bd263f 120 ProSitePatterns PS00354 HMG-I and HMG-Y DNA-binding domain (A+T-hook). 105 115 - T 17-03-2017 IPR000637 HMG-I/HMG-Y, DNA-binding, conserved site GO:0006355 SHXM_RS34310 0ac23dfce2d236248657958545bd263f 120 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 25 109 15.034 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS33540 b968e3aa70d314c57428182cb61d029f 184 Gene3D G3DSA:3.40.30.10 2 178 8.0E-61 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS33540 b968e3aa70d314c57428182cb61d029f 184 PIRSF PIRSF000239 1 184 3.9E-49 T 17-03-2017 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS33540 b968e3aa70d314c57428182cb61d029f 184 SUPERFAMILY SSF52833 2 177 1.09E-52 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS33540 b968e3aa70d314c57428182cb61d029f 184 Pfam PF00578 AhpC/TSA family 4 136 1.9E-32 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS25760 62f2ed3cd3b68dbff9365014673235b4 270 Gene3D G3DSA:3.40.50.300 8 241 7.5E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25760 62f2ed3cd3b68dbff9365014673235b4 270 Pfam PF00005 ABC transporter 25 172 1.5E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS25760 62f2ed3cd3b68dbff9365014673235b4 270 SMART SM00382 33 222 1.8E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS25760 62f2ed3cd3b68dbff9365014673235b4 270 SUPERFAMILY SSF52540 9 234 5.22E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25760 62f2ed3cd3b68dbff9365014673235b4 270 ProSitePatterns PS00211 ABC transporters family signature. 145 159 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 Pfam PF03471 Transporter associated domain 364 431 6.9E-16 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 Pfam PF01595 Domain of unknown function DUF21 10 201 6.1E-33 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 SUPERFAMILY SSF56176 363 434 3.0E-15 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 Gene3D G3DSA:3.10.580.10 209 330 5.0E-18 T 17-03-2017 SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 SMART SM01091 357 434 8.8E-19 T 17-03-2017 IPR005170 Transporter-associated domain SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 Pfam PF00571 CBS domain 283 335 1.4E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 SUPERFAMILY SSF54631 213 347 1.77E-27 T 17-03-2017 SHXM_RS08570 3f168e252ba6bac862d55272def2624f 454 Gene3D G3DSA:3.30.465.10 331 431 6.9E-22 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS14350 eb08b0ac56506756c960eff3339107e4 278 SUPERFAMILY SSF47413 12 77 3.94E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS14350 eb08b0ac56506756c960eff3339107e4 278 Gene3D G3DSA:1.10.260.40 20 77 3.0E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS14350 eb08b0ac56506756c960eff3339107e4 278 SMART SM00530 23 78 1.8E-12 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS14350 eb08b0ac56506756c960eff3339107e4 278 Pfam PF13560 Helix-turn-helix domain 20 81 4.8E-13 T 17-03-2017 SHXM_RS34115 dd73dd3272e5d5cffd7dabf8932337bb 156 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 1 21 1.6E-10 T 17-03-2017 IPR003998 Twin-arginine translocation protein TatB-like GO:0009306|GO:0016020 SHXM_RS34115 dd73dd3272e5d5cffd7dabf8932337bb 156 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 40 58 1.6E-10 T 17-03-2017 IPR003998 Twin-arginine translocation protein TatB-like GO:0009306|GO:0016020 SHXM_RS34115 dd73dd3272e5d5cffd7dabf8932337bb 156 PRINTS PR01506 Bacterial sec-independent translocation TatB protein signature 21 40 1.6E-10 T 17-03-2017 IPR003998 Twin-arginine translocation protein TatB-like GO:0009306|GO:0016020 SHXM_RS34115 dd73dd3272e5d5cffd7dabf8932337bb 156 Pfam PF02416 mttA/Hcf106 family 4 35 5.3E-5 T 17-03-2017 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 SHXM_RS34115 dd73dd3272e5d5cffd7dabf8932337bb 156 Hamap MF_00237 Sec-independent protein translocase protein TatB [tatB]. 1 147 14.212 T 17-03-2017 IPR018448 Twin-arginine translocation protein TatB GO:0016020|GO:0043953 SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 Gene3D G3DSA:3.90.180.10 1 169 2.5E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 SUPERFAMILY SSF50129 1 172 2.36E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 26 128 6.8E-23 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 Pfam PF00107 Zinc-binding dehydrogenase 178 305 1.2E-17 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 SUPERFAMILY SSF51735 148 310 2.45E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 Gene3D G3DSA:3.40.50.720 170 289 2.5E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41945 c184349ac5479ff59c275a14bf1304e8 344 SMART SM00829 8 342 0.0025 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 ProSitePatterns PS00936 Ribosomal protein L35 signature. 5 31 - T 17-03-2017 IPR018265 Ribosomal protein L35, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 Hamap MF_00514 50S ribosomal protein L35 [rpmI]. 1 64 17.238 T 17-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 Pfam PF01632 Ribosomal protein L35 2 62 1.5E-23 T 17-03-2017 IPR021137 Ribosomal protein L35 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 SUPERFAMILY SSF143034 2 63 1.57E-20 T 17-03-2017 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 PRINTS PR00064 Ribosomal protein L35 signature 3 20 7.1E-15 T 17-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 PRINTS PR00064 Ribosomal protein L35 signature 36 54 7.1E-15 T 17-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 PRINTS PR00064 Ribosomal protein L35 signature 21 35 7.1E-15 T 17-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SHXM_RS13140 fd07035ca089c07dca2d13709c3f8b33 64 TIGRFAM TIGR00001 rpmI_bact: ribosomal protein bL35 2 63 6.6E-24 T 17-03-2017 IPR001706 Ribosomal protein L35, non-mitochondrial GO:0003735|GO:0005840|GO:0006412 SHXM_RS27515 e0252fd31bd73246756af00016e75e69 147 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 47 134 6.0E-27 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS27515 e0252fd31bd73246756af00016e75e69 147 SMART SM00458 11 147 4.3E-15 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS27515 e0252fd31bd73246756af00016e75e69 147 Gene3D G3DSA:2.80.10.50 15 146 2.6E-36 T 17-03-2017 SHXM_RS27515 e0252fd31bd73246756af00016e75e69 147 SUPERFAMILY SSF50370 12 146 1.02E-43 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 SUPERFAMILY SSF52172 14 145 1.08E-29 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 Gene3D G3DSA:3.40.50.2300 13 166 2.1E-36 T 17-03-2017 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 Pfam PF00072 Response regulator receiver domain 17 128 3.1E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 SMART SM00421 164 221 4.2E-27 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 SUPERFAMILY SSF46894 155 222 3.74E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 Gene3D G3DSA:1.10.10.10 167 223 1.5E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 ProSitePatterns PS00622 LuxR-type HTH domain signature. 181 208 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 167 181 5.6E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 197 209 5.6E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 197 5.6E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 Pfam PF00196 Bacterial regulatory proteins, luxR family 167 221 4.2E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08030 24a1e3c06aab3169b22a14b439b20d6b 234 SMART SM00448 15 128 2.0E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 Gene3D G3DSA:1.10.10.10 33 165 7.7E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 SMART SM00347 50 151 7.7E-18 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 92 107 2.3E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 141 161 2.3E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 PRINTS PR00598 Bacterial regulatory protein MarR family signature 111 127 2.3E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 Pfam PF01047 MarR family 73 116 2.7E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS21135 d63cb84a19e25a0bee390a5d17ba8f43 183 SUPERFAMILY SSF46785 35 165 6.03E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11990 756c4481ddf51162c70d4aec29bc8815 88 Gene3D G3DSA:1.10.1200.10 2 79 3.0E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11990 756c4481ddf51162c70d4aec29bc8815 88 SUPERFAMILY SSF47336 1 78 4.45E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11990 756c4481ddf51162c70d4aec29bc8815 88 Pfam PF00550 Phosphopantetheine attachment site 7 76 4.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 Gene3D G3DSA:1.10.530.10 99 157 8.5E-59 T 17-03-2017 SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 Gene3D G3DSA:1.10.530.10 221 301 8.5E-59 T 17-03-2017 SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 Gene3D G3DSA:3.30.20.10 165 220 1.8E-25 T 17-03-2017 SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 PIRSF PIRSF001060 1 301 5.6E-89 T 17-03-2017 IPR016283 Glycoside hydrolase, family 19 GO:0004568|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 SMART SM00495 42 86 1.8E-4 T 17-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 Gene3D G3DSA:2.10.10.20 39 84 1.6E-5 T 17-03-2017 IPR003610 Carbohydrate-binding module family 5/12 GO:0004553|GO:0005576|GO:0005975|GO:0030246 SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 SUPERFAMILY SSF53955 98 301 2.62E-71 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS13240 54fd65e43eb930cc1644f74e9bc8a68d 301 Pfam PF00182 Chitinase class I 99 301 3.5E-47 T 17-03-2017 IPR000726 Glycoside hydrolase, family 19, catalytic GO:0004568|GO:0006032|GO:0016998 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS18295 6fd9f4bde42b7853170c1449db8b1f9c 338 Pfam PF01790 Prolipoprotein diacylglyceryl transferase 15 257 1.2E-63 T 17-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 SHXM_RS18295 6fd9f4bde42b7853170c1449db8b1f9c 338 Hamap MF_01147 Prolipoprotein diacylglyceryl transferase [lgt]. 9 263 15.706 T 17-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 SHXM_RS18295 6fd9f4bde42b7853170c1449db8b1f9c 338 ProSitePatterns PS01311 Prolipoprotein diacylglyceryl transferase signature. 141 153 - T 17-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 SHXM_RS18295 6fd9f4bde42b7853170c1449db8b1f9c 338 TIGRFAM TIGR00544 lgt: prolipoprotein diacylglyceryl transferase 9 258 3.4E-41 T 17-03-2017 IPR001640 Prolipoprotein diacylglyceryl transferase GO:0009249|GO:0016020|GO:0016757|GO:0042158 SHXM_RS36175 8208a299842e09aa1f0bbd9456717f21 252 SUPERFAMILY SSF48498 92 198 3.0E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS36175 8208a299842e09aa1f0bbd9456717f21 252 Gene3D G3DSA:1.10.357.10 15 202 1.2E-37 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS36175 8208a299842e09aa1f0bbd9456717f21 252 SUPERFAMILY SSF46689 14 93 6.62E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS36175 8208a299842e09aa1f0bbd9456717f21 252 Pfam PF00440 Bacterial regulatory proteins, tetR family 27 68 2.7E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36175 8208a299842e09aa1f0bbd9456717f21 252 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 27 40 2.0E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36175 8208a299842e09aa1f0bbd9456717f21 252 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 2.0E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 SMART SM00346 23 109 4.4E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 SUPERFAMILY SSF46785 23 91 1.12E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 Pfam PF09339 IclR helix-turn-helix domain 23 69 1.8E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 Pfam PF01614 Bacterial transcriptional regulator 142 261 9.2E-28 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 Gene3D G3DSA:1.10.10.10 23 87 5.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 SUPERFAMILY SSF55781 92 263 9.81E-43 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS02085 be9f49532722015c170fefa189cc42b6 277 Gene3D G3DSA:3.30.450.40 98 263 1.3E-46 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS02450 f47cb2cd9fe950c6ab9635c67bd26f3e 281 Gene3D G3DSA:1.10.260.40 7 84 4.1E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02450 f47cb2cd9fe950c6ab9635c67bd26f3e 281 SMART SM00530 13 85 5.6E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS02450 f47cb2cd9fe950c6ab9635c67bd26f3e 281 Pfam PF13560 Helix-turn-helix domain 9 84 2.7E-16 T 17-03-2017 SHXM_RS02450 f47cb2cd9fe950c6ab9635c67bd26f3e 281 SUPERFAMILY SSF47413 34 83 2.82E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40410 6a4b3c0cf12b6ba6c2ce9fe00930557e 292 SUPERFAMILY SSF47413 38 86 5.3E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40410 6a4b3c0cf12b6ba6c2ce9fe00930557e 292 Pfam PF13560 Helix-turn-helix domain 14 88 3.6E-12 T 17-03-2017 SHXM_RS40410 6a4b3c0cf12b6ba6c2ce9fe00930557e 292 SMART SM00530 17 89 0.0014 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS40410 6a4b3c0cf12b6ba6c2ce9fe00930557e 292 Gene3D G3DSA:1.10.260.40 13 86 1.6E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS34950 1bcf86da205a4ae861eb5d44ffadda52 309 SUPERFAMILY SSF47240 35 222 7.1E-11 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS34950 1bcf86da205a4ae861eb5d44ffadda52 309 Pfam PF11583 P-aminobenzoate N-oxygenase AurF 18 292 8.2E-101 T 17-03-2017 IPR025859 P-aminobenzoate N-oxygenase AurF SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 Gene3D G3DSA:3.40.1410.10 91 249 8.8E-50 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 Pfam PF00392 Bacterial regulatory proteins, gntR family 26 88 3.2E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 SUPERFAMILY SSF64288 76 250 4.55E-46 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 Pfam PF07702 UTRA domain 109 245 7.2E-37 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 48 62 1.5E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 62 78 1.5E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 SUPERFAMILY SSF46785 18 92 5.91E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 SMART SM00345 29 88 7.9E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 SMART SM00866 108 246 3.9E-35 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS39085 f600c83dacd2dcdab3ca5f5e51e592a2 255 Gene3D G3DSA:1.10.10.10 18 90 8.7E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19615 32fb03455b52b5a4b2e91a7c7d5ddd73 122 Pfam PF13591 MerR HTH family regulatory protein 30 110 3.6E-10 T 17-03-2017 SHXM_RS40025 32fb03455b52b5a4b2e91a7c7d5ddd73 122 Pfam PF13591 MerR HTH family regulatory protein 30 110 3.6E-10 T 17-03-2017 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 Pfam PF01642 Methylmalonyl-CoA mutase 52 569 1.8E-235 T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 ProSitePatterns PS00544 Methylmalonyl-CoA mutase signature. 393 418 - T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 SUPERFAMILY SSF52242 574 737 4.06E-58 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 Pfam PF02310 B12 binding domain 611 721 1.6E-14 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 TIGRFAM TIGR00640 acid_CoA_mut_C: methylmalonyl-CoA mutase C-terminal domain 608 735 3.6E-61 T 17-03-2017 IPR006159 Methylmalonyl-CoA mutase, C-terminal GO:0016853 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 Gene3D G3DSA:3.20.20.240 49 516 2.2E-210 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 50 576 2.7E-279 T 17-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 SUPERFAMILY SSF51703 39 571 1.91E-223 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07350 ac4776741b3547e9fb7cfb0576f92573 742 Gene3D G3DSA:3.40.50.280 575 734 1.1E-70 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS46265 03322eceda636240c0822cc5c177fe23 127 Gene3D G3DSA:3.40.30.10 11 91 0.001 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS44105 444bc58fbb78843470a36b51b69002f8 177 SUPERFAMILY SSF54427 47 164 2.53E-9 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS44105 444bc58fbb78843470a36b51b69002f8 177 Gene3D G3DSA:3.10.450.50 44 159 1.3E-6 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 SUPERFAMILY SSF46785 22 98 2.18E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 SUPERFAMILY SSF53850 113 317 1.99E-28 T 17-03-2017 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 Gene3D G3DSA:3.40.190.10 133 182 1.5E-5 T 17-03-2017 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 Gene3D G3DSA:3.40.190.10 290 316 1.5E-5 T 17-03-2017 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 24 80 4.6E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 Gene3D G3DSA:3.40.190.10 183 279 3.7E-19 T 17-03-2017 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 Gene3D G3DSA:1.10.10.10 22 98 8.1E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 Pfam PF03466 LysR substrate binding domain 121 315 2.7E-27 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 60 71 2.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 2.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS04825 f372e8f60b683b9dc96e3a85b0560a9a 318 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 50 60 2.0E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44005 f7f0c8d371c8188b8ed3131fa9c7e844 142 Gene3D G3DSA:3.30.530.20 1 141 1.2E-17 T 17-03-2017 IPR023393 START-like domain SHXM_RS44005 f7f0c8d371c8188b8ed3131fa9c7e844 142 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 1 139 4.1E-21 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS44005 f7f0c8d371c8188b8ed3131fa9c7e844 142 SUPERFAMILY SSF55961 1 141 1.28E-22 T 17-03-2017 SHXM_RS21935 abb5c1350b801aadf05e676617347218 336 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 3 302 3.7E-14 T 17-03-2017 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 SHXM_RS21935 abb5c1350b801aadf05e676617347218 336 SUPERFAMILY SSF53067 116 306 2.11E-34 T 17-03-2017 SHXM_RS21935 abb5c1350b801aadf05e676617347218 336 SUPERFAMILY SSF53067 1 108 3.46E-14 T 17-03-2017 SHXM_RS21935 abb5c1350b801aadf05e676617347218 336 Gene3D G3DSA:3.30.420.40 122 291 1.6E-7 T 17-03-2017 SHXM_RS49760 45839db4c5bf271097645cb52bb2f9d8 645 SMART SM00065 87 244 1.0E-24 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS49760 45839db4c5bf271097645cb52bb2f9d8 645 Gene3D G3DSA:3.30.450.40 63 250 3.3E-33 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS49760 45839db4c5bf271097645cb52bb2f9d8 645 SUPERFAMILY SSF55781 70 261 1.2E-28 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS49760 45839db4c5bf271097645cb52bb2f9d8 645 Pfam PF13185 GAF domain 86 235 1.2E-15 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS49760 45839db4c5bf271097645cb52bb2f9d8 645 Pfam PF13556 PucR C-terminal helix-turn-helix domain 579 637 1.5E-16 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS32975 76fd76c66f8de1f91e1737c3362fe9ec 297 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 26 65 4.4E-10 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS32975 76fd76c66f8de1f91e1737c3362fe9ec 297 Gene3D G3DSA:1.10.3720.10 84 292 1.3E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32975 76fd76c66f8de1f91e1737c3362fe9ec 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 292 2.9E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32975 76fd76c66f8de1f91e1737c3362fe9ec 297 SUPERFAMILY SSF161098 89 276 1.24E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 Gene3D G3DSA:3.10.450.50 165 279 2.5E-9 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 SUPERFAMILY SSF88659 72 157 1.12E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 SUPERFAMILY SSF88946 6 86 3.81E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 154 3.6E-23 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 Gene3D G3DSA:1.10.1740.10 6 71 2.9E-11 T 17-03-2017 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 Pfam PF08281 Sigma-70, region 4 103 153 7.6E-13 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 Pfam PF04542 Sigma-70 region 2 8 70 1.1E-14 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 TIGRFAM TIGR02957 SigX4: RNA polymerase sigma-70 factor, TIGR02957 family 6 280 2.8E-103 T 17-03-2017 IPR014303 RNA polymerase sigma-70, ECF type SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 Gene3D G3DSA:1.10.10.10 103 156 4.2E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46305 f2413e08aec6829fc2a52cc6f7bfde82 288 SUPERFAMILY SSF54427 166 283 6.23E-14 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS16740 ecaacf04dd4a691270adab6dd69a7d7e 225 Pfam PF01596 O-methyltransferase 21 219 9.9E-63 T 17-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 SHXM_RS16740 ecaacf04dd4a691270adab6dd69a7d7e 225 SUPERFAMILY SSF53335 15 219 5.73E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16740 ecaacf04dd4a691270adab6dd69a7d7e 225 Gene3D G3DSA:3.40.50.150 8 219 2.6E-77 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03235 325a54a4f93afeb0ca80d6689a5de440 474 Gene3D G3DSA:3.40.1670.10 326 440 3.3E-31 T 17-03-2017 SHXM_RS03235 325a54a4f93afeb0ca80d6689a5de440 474 SUPERFAMILY SSF143968 312 466 1.83E-37 T 17-03-2017 SHXM_RS03235 325a54a4f93afeb0ca80d6689a5de440 474 TIGRFAM TIGR00148 TIGR00148: decarboxylase, UbiD family 6 441 1.8E-122 T 17-03-2017 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 SHXM_RS03235 325a54a4f93afeb0ca80d6689a5de440 474 SUPERFAMILY SSF50475 3 309 1.22E-82 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS03235 325a54a4f93afeb0ca80d6689a5de440 474 Pfam PF01977 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 10 416 1.3E-106 T 17-03-2017 IPR002830 UbiD decarboxylyase family GO:0016831 KEGG: 00130+4.1.1.98|MetaCyc: PWY-5855|MetaCyc: PWY-5856|MetaCyc: PWY-5857|MetaCyc: PWY-6708|MetaCyc: PWY-6978 SHXM_RS07115 75c5c3246948500d098db068bbef23b8 283 SUPERFAMILY SSF56300 217 260 1.67E-23 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS07115 75c5c3246948500d098db068bbef23b8 283 SUPERFAMILY SSF56300 7 169 1.67E-23 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS07115 75c5c3246948500d098db068bbef23b8 283 Gene3D G3DSA:3.60.21.10 177 260 2.0E-22 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS07115 75c5c3246948500d098db068bbef23b8 283 Gene3D G3DSA:3.60.21.10 9 83 2.0E-22 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS07115 75c5c3246948500d098db068bbef23b8 283 Pfam PF00149 Calcineurin-like phosphoesterase 9 242 1.1E-15 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS38655 fa0debbb122b52afda6eef19e84029ad 67 Pfam PF04149 Domain of unknown function (DUF397) 5 58 5.6E-12 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS36195 b72bd415c09471520a903f68b533dde6 194 SUPERFAMILY SSF52980 12 169 4.88E-20 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS36195 b72bd415c09471520a903f68b533dde6 194 Pfam PF05685 Putative restriction endonuclease 20 181 8.1E-26 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS36195 b72bd415c09471520a903f68b533dde6 194 Gene3D G3DSA:3.90.1570.10 13 149 4.9E-19 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS37590 0bffcbeb9061a183ae2747ae42e3e19e 383 SUPERFAMILY SSF53800 12 339 4.74E-80 T 17-03-2017 SHXM_RS37590 0bffcbeb9061a183ae2747ae42e3e19e 383 Gene3D G3DSA:3.40.50.1400 169 315 2.8E-46 T 17-03-2017 SHXM_RS37590 0bffcbeb9061a183ae2747ae42e3e19e 383 Hamap MF_00323 Ferrochelatase [hemH]. 12 336 30.207 T 17-03-2017 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|Reactome: R-HSA-189451 SHXM_RS37590 0bffcbeb9061a183ae2747ae42e3e19e 383 Pfam PF00762 Ferrochelatase 14 335 1.2E-93 T 17-03-2017 IPR001015 Ferrochelatase GO:0004325|GO:0006783 KEGG: 00860+4.99.1.1|Reactome: R-HSA-189451 SHXM_RS37590 0bffcbeb9061a183ae2747ae42e3e19e 383 Gene3D G3DSA:3.40.50.1400 11 168 2.0E-41 T 17-03-2017 SHXM_RS44115 9712c71790195a030dd75dd015d409f5 241 SUPERFAMILY SSF51735 11 241 2.68E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44115 9712c71790195a030dd75dd015d409f5 241 Gene3D G3DSA:3.40.50.720 7 236 7.0E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44115 9712c71790195a030dd75dd015d409f5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44115 9712c71790195a030dd75dd015d409f5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44115 9712c71790195a030dd75dd015d409f5 241 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 2.0E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44115 9712c71790195a030dd75dd015d409f5 241 Pfam PF00106 short chain dehydrogenase 12 200 7.6E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40315 8d3082e58189240ebfc24e6cc8c9b2ec 80 Pfam PF13701 Transposase DDE domain group 1 2 70 6.2E-10 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 SUPERFAMILY SSF53383 9 419 4.26E-161 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 Gene3D G3DSA:3.40.640.10 39 284 9.8E-92 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 9 419 48.282 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 Gene3D G3DSA:3.90.1150.10 285 419 2.2E-50 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 Pfam PF00464 Serine hydroxymethyltransferase 11 386 2.7E-151 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 224 240 - T 17-03-2017 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0004372|GO:0006544|GO:0006563|GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS25165 8425db2ce2c0bb30546423b801a3a63d 423 PIRSF PIRSF000412 2 421 8.9E-161 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS49965 6a92f3a2798eb4a02acd8373a4ffed04 184 Pfam PF07336 Putative stress-induced transcription regulator 12 115 2.5E-13 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS49965 6a92f3a2798eb4a02acd8373a4ffed04 184 Gene3D G3DSA:1.10.3300.10 9 183 2.1E-40 T 17-03-2017 IPR023286 ABATE domain SHXM_RS49965 6a92f3a2798eb4a02acd8373a4ffed04 184 Pfam PF11706 CGNR zinc finger 139 182 1.0E-19 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS49965 6a92f3a2798eb4a02acd8373a4ffed04 184 SUPERFAMILY SSF160904 7 181 1.18E-35 T 17-03-2017 SHXM_RS27855 6ac464e4a281e867672ce075e0354c2e 105 Gene3D G3DSA:2.60.120.10 2 104 6.4E-23 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS27855 6ac464e4a281e867672ce075e0354c2e 105 Pfam PF07883 Cupin domain 33 100 4.2E-14 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS27855 6ac464e4a281e867672ce075e0354c2e 105 SUPERFAMILY SSF51182 19 103 4.56E-20 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS37830 e04781edf06c945065270e5b530d77f3 430 Gene3D G3DSA:3.40.50.2000 10 134 3.1E-12 T 17-03-2017 SHXM_RS37830 e04781edf06c945065270e5b530d77f3 430 Gene3D G3DSA:3.40.50.2000 228 380 7.3E-38 T 17-03-2017 SHXM_RS37830 e04781edf06c945065270e5b530d77f3 430 SUPERFAMILY SSF53756 9 397 5.14E-82 T 17-03-2017 SHXM_RS37830 e04781edf06c945065270e5b530d77f3 430 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 233 368 1.5E-16 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS37830 e04781edf06c945065270e5b530d77f3 430 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 13 397 3.6E-121 T 17-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SHXM_RS23565 b74b963bb223d2c4a0aa9f8193362f1f 261 Pfam PF05362 Lon protease (S16) C-terminal proteolytic domain 153 236 8.0E-6 T 17-03-2017 IPR008269 Peptidase S16, Lon C-terminal GO:0004176|GO:0004252|GO:0006508 SHXM_RS23565 b74b963bb223d2c4a0aa9f8193362f1f 261 SUPERFAMILY SSF54211 116 249 3.3E-17 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS23565 b74b963bb223d2c4a0aa9f8193362f1f 261 Gene3D G3DSA:3.30.230.10 112 249 1.8E-20 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS25075 4705824cf77ed16a98fdacd0b9ecbe26 298 Gene3D G3DSA:1.10.101.10 91 160 2.4E-17 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS25075 4705824cf77ed16a98fdacd0b9ecbe26 298 Pfam PF01471 Putative peptidoglycan binding domain 98 154 7.8E-14 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS25075 4705824cf77ed16a98fdacd0b9ecbe26 298 SUPERFAMILY SSF141523 184 297 2.75E-21 T 17-03-2017 SHXM_RS25075 4705824cf77ed16a98fdacd0b9ecbe26 298 SUPERFAMILY SSF47090 86 158 1.88E-18 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS25075 4705824cf77ed16a98fdacd0b9ecbe26 298 Pfam PF03734 L,D-transpeptidase catalytic domain 185 296 6.1E-16 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS25075 4705824cf77ed16a98fdacd0b9ecbe26 298 Gene3D G3DSA:2.40.440.10 185 297 2.7E-15 T 17-03-2017 SHXM_RS01670 f1b2e637a06e62d1749b75c1fd6fb222 310 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 104 302 1.1E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01670 f1b2e637a06e62d1749b75c1fd6fb222 310 Gene3D G3DSA:1.10.3720.10 23 293 6.1E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01670 f1b2e637a06e62d1749b75c1fd6fb222 310 SUPERFAMILY SSF161098 24 295 2.62E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12950 2c555c2f475359e1263f4903540ec69b 350 SUPERFAMILY SSF53850 34 346 3.37E-62 T 17-03-2017 SHXM_RS12950 2c555c2f475359e1263f4903540ec69b 350 Gene3D G3DSA:3.40.190.10 136 273 3.6E-23 T 17-03-2017 SHXM_RS12950 2c555c2f475359e1263f4903540ec69b 350 Pfam PF13416 Bacterial extracellular solute-binding protein 51 311 2.8E-29 T 17-03-2017 SHXM_RS12950 2c555c2f475359e1263f4903540ec69b 350 Gene3D G3DSA:3.40.190.10 6 133 1.9E-25 T 17-03-2017 SHXM_RS12950 2c555c2f475359e1263f4903540ec69b 350 Gene3D G3DSA:3.40.190.10 274 323 1.9E-25 T 17-03-2017 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 SUPERFAMILY SSF53067 17 268 5.18E-93 T 17-03-2017 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 Gene3D G3DSA:3.30.420.40 268 512 5.6E-102 T 17-03-2017 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 18 265 3.5E-79 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 16 510 3.1E-227 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 274 464 4.7E-66 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 SUPERFAMILY SSF53067 268 511 1.7E-81 T 17-03-2017 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 376 396 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 PIRSF PIRSF000538 15 515 5.8E-169 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 Hamap MF_00186 Glycerol kinase [glpK]. 15 511 55.994 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS15995 dd594e97e56961aa6e229bada23cd970 515 Gene3D G3DSA:3.30.420.40 15 266 3.6E-108 T 17-03-2017 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 SMART SM00421 141 198 1.8E-24 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 Pfam PF00196 Bacterial regulatory proteins, luxR family 143 197 2.2E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 Pfam PF00072 Response regulator receiver domain 3 114 5.3E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 174 186 1.3E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 174 1.3E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 144 158 1.3E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 SUPERFAMILY SSF46894 138 204 1.16E-19 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 Gene3D G3DSA:1.10.10.10 120 204 2.0E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 SMART SM00448 1 114 2.3E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 Gene3D G3DSA:3.40.50.2300 1 119 2.4E-39 T 17-03-2017 SHXM_RS07185 62d65cb43ee862d9ec949a0dabb39d0a 205 SUPERFAMILY SSF52172 1 132 3.84E-36 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS38410 7fbc8bad7266acd288b89a2146990224 330 Gene3D G3DSA:1.10.1530.10 5 73 5.1E-7 T 17-03-2017 SHXM_RS38410 7fbc8bad7266acd288b89a2146990224 330 Gene3D G3DSA:3.30.1370.60 74 261 1.5E-55 T 17-03-2017 SHXM_RS38410 7fbc8bad7266acd288b89a2146990224 330 SUPERFAMILY SSF89733 1 328 3.4E-76 T 17-03-2017 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS38410 7fbc8bad7266acd288b89a2146990224 330 Pfam PF02615 Malate/L-lactate dehydrogenase 7 323 2.5E-88 T 17-03-2017 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS47630 dba14d69b587268e6cd118483c58b755 192 SUPERFAMILY SSF53850 10 183 1.48E-24 T 17-03-2017 SHXM_RS47630 dba14d69b587268e6cd118483c58b755 192 Gene3D G3DSA:3.40.190.10 10 60 5.3E-8 T 17-03-2017 SHXM_RS47630 dba14d69b587268e6cd118483c58b755 192 Gene3D G3DSA:3.40.190.10 61 148 3.6E-26 T 17-03-2017 SHXM_RS47630 dba14d69b587268e6cd118483c58b755 192 Pfam PF03466 LysR substrate binding domain 9 178 3.0E-28 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 TIGRFAM TIGR01963 PHB_DH: 3-hydroxybutyrate dehydrogenase 31 272 3.7E-94 T 17-03-2017 IPR011294 3-hydroxybutyrate dehydrogenase GO:0003858|GO:0055114 SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 Gene3D G3DSA:3.40.50.720 25 271 5.7E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 154 182 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 SUPERFAMILY SSF51735 29 271 6.26E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 167 186 9.9E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 147 155 9.9E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 94 105 9.9E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 141 157 2.1E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 167 186 2.1E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 32 49 2.1E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 233 253 2.1E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 188 205 2.1E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 94 105 2.1E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49765 5c28ddf888f069344d6585ebc84bf8d8 272 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 37 270 1.7E-50 T 17-03-2017 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Pfam PF02913 FAD linked oxidases, C-terminal domain 274 519 1.4E-47 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Pfam PF02754 Cysteine-rich domain 741 814 0.01 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Gene3D G3DSA:3.30.465.10 104 272 1.1E-32 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 SUPERFAMILY SSF56176 27 274 5.09E-52 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 SUPERFAMILY SSF46548 538 641 7.85E-10 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Gene3D G3DSA:1.10.1060.10 556 651 3.3E-12 T 17-03-2017 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 623 634 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Pfam PF01565 FAD binding domain 49 187 1.9E-37 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 SUPERFAMILY SSF55103 277 525 3.43E-51 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Gene3D G3DSA:3.30.43.10 9 103 7.7E-19 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS40645 5f09e937ca0d7ce535d93f7831b53703 964 Pfam PF13183 4Fe-4S dicluster domain 559 637 9.9E-10 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 SUPERFAMILY SSF55797 202 324 4.53E-10 T 17-03-2017 IPR014044 CAP domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 Pfam PF02342 TerD domain 25 153 1.3E-16 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 SUPERFAMILY SSF55797 337 457 6.02E-27 T 17-03-2017 IPR014044 CAP domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 Gene3D G3DSA:3.40.33.10 203 287 9.1E-5 T 17-03-2017 IPR014044 CAP domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 Gene3D G3DSA:3.40.33.10 337 456 2.6E-14 T 17-03-2017 IPR014044 CAP domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 Pfam PF00188 Cysteine-rich secretory protein family 206 320 7.1E-9 T 17-03-2017 IPR014044 CAP domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 Pfam PF00188 Cysteine-rich secretory protein family 341 456 1.4E-24 T 17-03-2017 IPR014044 CAP domain SHXM_RS44920 dbb535444b151358074fef681e5ff09a 459 Gene3D G3DSA:2.60.60.30 26 151 1.2E-13 T 17-03-2017 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SUPERFAMILY SSF48452 533 613 4.14E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 Gene3D G3DSA:1.25.40.10 598 780 7.2E-20 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 PRINTS PR00364 Disease resistance protein signature 127 142 5.2E-8 T 17-03-2017 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 PRINTS PR00364 Disease resistance protein signature 204 218 5.2E-8 T 17-03-2017 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 PRINTS PR00364 Disease resistance protein signature 291 305 5.2E-8 T 17-03-2017 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 Gene3D G3DSA:3.40.50.300 113 219 1.8E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 Pfam PF13181 Tetratricopeptide repeat 544 576 5.6E-4 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SUPERFAMILY SSF48452 586 772 2.93E-18 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 Pfam PF00931 NB-ARC domain 107 311 3.8E-13 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 Gene3D G3DSA:1.25.40.10 540 597 6.5E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 Pfam PF13424 Tetratricopeptide repeat 583 653 5.2E-9 T 17-03-2017 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SMART SM00028 544 577 0.0077 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SMART SM00028 662 695 12.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SMART SM00028 702 735 70.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SMART SM00028 741 774 160.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SMART SM00028 582 615 3.9 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SMART SM00028 622 655 310.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31825 229f9b75603e1e0df204c2194a6425d8 820 SUPERFAMILY SSF52540 97 358 1.98E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 SUPERFAMILY SSF54373 187 283 3.61E-15 T 17-03-2017 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 Gene3D G3DSA:3.50.50.60 288 373 1.2E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 Gene3D G3DSA:3.50.50.60 7 187 1.2E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 Pfam PF01494 FAD binding domain 8 364 6.0E-25 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 316 332 6.1E-21 T 17-03-2017 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 301 316 6.1E-21 T 17-03-2017 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 8 30 6.1E-21 T 17-03-2017 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 161 176 6.1E-21 T 17-03-2017 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 SUPERFAMILY SSF51905 288 389 1.3E-60 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01375 1ab708b17d9d2877bf51673b19d29b4a 422 SUPERFAMILY SSF51905 7 182 1.3E-60 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 TIGRFAM TIGR01263 4HPPD: 4-hydroxyphenylpyruvate dioxygenase 23 382 1.8E-135 T 17-03-2017 IPR005956 4-hydroxyphenylpyruvate dioxygenase GO:0003868|GO:0009072|GO:0016701|GO:0055114 SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 Gene3D G3DSA:3.10.180.10 16 187 1.3E-44 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 SUPERFAMILY SSF54593 16 369 2.44E-92 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 23 136 1.8E-4 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 186 336 1.9E-17 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 PIRSF PIRSF009283 10 382 1.5E-135 T 17-03-2017 IPR005956 4-hydroxyphenylpyruvate dioxygenase GO:0003868|GO:0009072|GO:0016701|GO:0055114 SHXM_RS23540 b93d7105b22335ef8e929b36a04d56f8 382 Gene3D G3DSA:3.10.180.10 188 382 4.9E-81 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS04370 e5c12aea614fcafeedb91bcfe7e93747 209 Gene3D G3DSA:3.40.366.10 85 166 3.2E-9 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS04370 e5c12aea614fcafeedb91bcfe7e93747 209 SUPERFAMILY SSF52151 85 166 2.25E-12 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS20840 ea66afef64f916292a631d17ac822994 255 Gene3D G3DSA:2.60.130.10 31 253 1.6E-70 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS20840 ea66afef64f916292a631d17ac822994 255 Pfam PF12391 Protocatechuate 3,4-dioxygenase beta subunit N terminal 26 55 1.5E-14 T 17-03-2017 IPR024756 Protocatechuate 3,4-dioxygenase beta subunit, N-terminal KEGG: 00362+1.13.11.3|KEGG: 00624+1.13.11.3 SHXM_RS20840 ea66afef64f916292a631d17ac822994 255 SUPERFAMILY SSF49482 30 252 3.01E-66 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS20840 ea66afef64f916292a631d17ac822994 255 TIGRFAM TIGR02422 protocat_beta: protocatechuate 3,4-dioxygenase, beta subunit 32 253 4.3E-108 T 17-03-2017 IPR012785 Protocatechuate 3,4-dioxygenase, beta subunit GO:0005506|GO:0018578|GO:0019619|GO:0055114 KEGG: 00362+1.13.11.3|KEGG: 00624+1.13.11.3 SHXM_RS20840 ea66afef64f916292a631d17ac822994 255 Pfam PF00775 Dioxygenase 66 245 4.1E-56 T 17-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 SHXM_RS20840 ea66afef64f916292a631d17ac822994 255 ProSitePatterns PS00083 Intradiol ring-cleavage dioxygenases signature. 96 124 - T 17-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 SHXM_RS10410 84e0dc435286844eb7596209a7e8c960 400 Pfam PF01548 Transposase 11 166 6.5E-44 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS10410 84e0dc435286844eb7596209a7e8c960 400 Pfam PF02371 Transposase IS116/IS110/IS902 family 275 357 5.7E-23 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS47395 84e0dc435286844eb7596209a7e8c960 400 Pfam PF01548 Transposase 11 166 6.5E-44 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS47395 84e0dc435286844eb7596209a7e8c960 400 Pfam PF02371 Transposase IS116/IS110/IS902 family 275 357 5.7E-23 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 PRINTS PR00757 Flavin-containing amine oxidase signature 240 262 4.9E-5 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 PRINTS PR00757 Flavin-containing amine oxidase signature 41 60 4.9E-5 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Pfam PF01593 Flavin containing amine oxidoreductase 49 522 2.2E-46 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Gene3D G3DSA:3.50.50.60 307 350 2.8E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Gene3D G3DSA:3.50.50.60 490 535 2.8E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Gene3D G3DSA:3.90.660.10 73 143 2.7E-26 T 17-03-2017 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Gene3D G3DSA:3.90.660.10 354 455 2.7E-26 T 17-03-2017 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Gene3D G3DSA:3.50.50.60 37 72 3.6E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 Gene3D G3DSA:3.50.50.60 268 306 3.6E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 SUPERFAMILY SSF51905 37 371 7.22E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 SUPERFAMILY SSF51905 486 528 7.22E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22110 569ecc1730f9f749520d3bb204f7405e 552 SUPERFAMILY SSF54373 350 465 2.42E-24 T 17-03-2017 SHXM_RS49815 33bd01c4d6cc6b04ca764b30993c0116 97 Pfam PF13277 YmdB-like protein 8 92 5.1E-18 T 17-03-2017 IPR005235 Metallophosphoesterase, YmdB-like SHXM_RS49815 33bd01c4d6cc6b04ca764b30993c0116 97 Gene3D G3DSA:3.60.21.30 4 96 3.3E-24 T 17-03-2017 SHXM_RS49815 33bd01c4d6cc6b04ca764b30993c0116 97 SUPERFAMILY SSF56300 4 91 1.9E-13 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS17805 0116c381fee1b342b84a5b5635631188 154 SUPERFAMILY SSF82649 2 143 1.88E-44 T 17-03-2017 SHXM_RS17805 0116c381fee1b342b84a5b5635631188 154 Pfam PF01592 NifU-like N terminal domain 6 129 2.3E-27 T 17-03-2017 IPR002871 NIF system FeS cluster assembly, NifU, N-terminal GO:0005506|GO:0016226|GO:0051536 Reactome: R-HSA-1362409 SHXM_RS17805 0116c381fee1b342b84a5b5635631188 154 Gene3D G3DSA:3.90.1010.10 5 147 2.9E-46 T 17-03-2017 SHXM_RS17805 0116c381fee1b342b84a5b5635631188 154 TIGRFAM TIGR01994 SUF_scaf_2: SUF system FeS assembly protein, NifU family 3 140 1.3E-48 T 17-03-2017 SHXM_RS42470 05daccd8109c1c6228df55e0898cc598 311 SUPERFAMILY SSF53213 7 287 5.36E-40 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS42470 05daccd8109c1c6228df55e0898cc598 311 Pfam PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase 9 271 2.9E-24 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS42470 05daccd8109c1c6228df55e0898cc598 311 Gene3D G3DSA:3.40.830.10 1 283 3.1E-19 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS37250 4e700fb9e358df82bc73756b21cc6c69 128 SUPERFAMILY SSF52821 14 127 2.49E-20 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37250 4e700fb9e358df82bc73756b21cc6c69 128 SMART SM00450 21 126 3.5E-18 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37250 4e700fb9e358df82bc73756b21cc6c69 128 Pfam PF00581 Rhodanese-like domain 31 122 3.1E-10 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS37250 4e700fb9e358df82bc73756b21cc6c69 128 Gene3D G3DSA:3.40.250.10 12 127 1.2E-20 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 31 437 3.7E-82 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 Pfam PF07690 Major Facilitator Superfamily 35 426 3.5E-62 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 Gene3D G3DSA:1.20.1250.20 282 471 4.6E-18 T 17-03-2017 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 Gene3D G3DSA:1.20.1250.20 21 215 6.6E-38 T 17-03-2017 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 33 57 3.4E-7 T 17-03-2017 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 155 179 3.4E-7 T 17-03-2017 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 278 303 3.4E-7 T 17-03-2017 SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 SUPERFAMILY SSF103473 19 217 3.14E-75 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14845 25ad33197ff6127992015d0faccfdc6e 496 SUPERFAMILY SSF103473 265 471 3.14E-75 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16280 2d9ea09f670e5a0f258d3587cab4523e 639 SUPERFAMILY SSF53448 172 434 8.21E-36 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS16280 2d9ea09f670e5a0f258d3587cab4523e 639 Gene3D G3DSA:3.90.550.10 177 412 5.9E-12 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS16280 2d9ea09f670e5a0f258d3587cab4523e 639 Pfam PF13632 Glycosyl transferase family group 2 258 454 8.6E-18 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS02205 1b930a4aaae1ae2ac51ea9884375341e 262 PRINTS PR00164 ABC-2 type transport system membrane protein signature 25 46 2.1E-5 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS02205 1b930a4aaae1ae2ac51ea9884375341e 262 PRINTS PR00164 ABC-2 type transport system membrane protein signature 101 126 2.1E-5 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS02205 1b930a4aaae1ae2ac51ea9884375341e 262 PRINTS PR00164 ABC-2 type transport system membrane protein signature 174 193 2.1E-5 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS02205 1b930a4aaae1ae2ac51ea9884375341e 262 PIRSF PIRSF006648 1 261 1.4E-68 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS02205 1b930a4aaae1ae2ac51ea9884375341e 262 Pfam PF01061 ABC-2 type transporter 7 214 8.2E-34 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS18875 b589d51aeaefcf809ce7f8b3de41ee00 351 PRINTS PR00162 Rieske 2Fe-2S subunit signature 272 283 7.1E-6 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS18875 b589d51aeaefcf809ce7f8b3de41ee00 351 PRINTS PR00162 Rieske 2Fe-2S subunit signature 308 320 7.1E-6 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS18875 b589d51aeaefcf809ce7f8b3de41ee00 351 PRINTS PR00162 Rieske 2Fe-2S subunit signature 294 306 7.1E-6 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS18875 b589d51aeaefcf809ce7f8b3de41ee00 351 SUPERFAMILY SSF50022 168 350 2.49E-29 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS18875 b589d51aeaefcf809ce7f8b3de41ee00 351 Gene3D G3DSA:2.102.10.10 208 350 1.0E-34 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS18875 b589d51aeaefcf809ce7f8b3de41ee00 351 Pfam PF00355 Rieske [2Fe-2S] domain 238 322 2.4E-10 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS37560 5c0206200840fd66d16892ef47a182c8 257 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 155 249 1.0E-6 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS37560 5c0206200840fd66d16892ef47a182c8 257 SUPERFAMILY SSF54593 13 229 8.17E-18 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS37560 5c0206200840fd66d16892ef47a182c8 257 Gene3D G3DSA:3.10.180.10 12 126 4.4E-29 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS37560 5c0206200840fd66d16892ef47a182c8 257 Gene3D G3DSA:3.10.180.10 139 253 2.7E-25 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS24895 3e4f547a53048d5e80ac356ad74bddd9 162 Gene3D G3DSA:3.40.50.450 3 157 1.1E-9 T 17-03-2017 SHXM_RS24895 3e4f547a53048d5e80ac356ad74bddd9 162 SUPERFAMILY SSF102405 1 158 1.46E-16 T 17-03-2017 SHXM_RS22410 67c0d5bf1b92a3f5a29d9cbf3b563b68 252 SUPERFAMILY SSF51182 18 149 1.86E-13 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS22410 67c0d5bf1b92a3f5a29d9cbf3b563b68 252 Gene3D G3DSA:2.60.120.10 20 97 3.6E-9 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 Gene3D G3DSA:3.40.50.1010 14 72 5.9E-10 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 Gene3D G3DSA:3.40.50.1010 109 157 5.9E-10 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 SUPERFAMILY SSF88723 109 155 3.27E-7 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 SUPERFAMILY SSF88723 14 72 3.27E-7 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 Pfam PF13638 PIN domain 15 157 5.5E-25 T 17-03-2017 IPR002716 PIN domain SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 Gene3D G3DSA:3.40.50.300 233 439 1.4E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 SMART SM00670 13 144 2.9E-13 T 17-03-2017 IPR002716 PIN domain SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 Pfam PF02562 PhoH-like protein 234 439 3.8E-54 T 17-03-2017 IPR003714 PhoH-like protein GO:0005524 SHXM_RS33520 de588c37ccea8acc96429466f4e18f6f 444 SUPERFAMILY SSF52540 233 396 1.65E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23810 0b86991ddd89ad97924e8a3fe17c5974 308 SUPERFAMILY SSF51735 111 253 1.81E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23810 0b86991ddd89ad97924e8a3fe17c5974 308 Gene3D G3DSA:3.90.180.10 2 138 1.0E-23 T 17-03-2017 IPR011032 GroES-like SHXM_RS23810 0b86991ddd89ad97924e8a3fe17c5974 308 SMART SM00829 9 305 5.1E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS23810 0b86991ddd89ad97924e8a3fe17c5974 308 Gene3D G3DSA:3.40.50.720 139 240 4.0E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23810 0b86991ddd89ad97924e8a3fe17c5974 308 SUPERFAMILY SSF50129 8 140 2.83E-19 T 17-03-2017 IPR011032 GroES-like SHXM_RS23810 0b86991ddd89ad97924e8a3fe17c5974 308 Pfam PF00107 Zinc-binding dehydrogenase 144 247 1.0E-10 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS22285 bde7be2e92fc422125b654cf85ace396 339 Gene3D G3DSA:3.40.50.720 3 140 8.6E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22285 bde7be2e92fc422125b654cf85ace396 339 Gene3D G3DSA:3.30.360.10 141 329 1.8E-29 T 17-03-2017 SHXM_RS22285 bde7be2e92fc422125b654cf85ace396 339 SUPERFAMILY SSF55347 136 291 1.31E-13 T 17-03-2017 SHXM_RS22285 bde7be2e92fc422125b654cf85ace396 339 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 8 128 4.0E-24 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS22285 bde7be2e92fc422125b654cf85ace396 339 SUPERFAMILY SSF51735 5 157 8.26E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22285 bde7be2e92fc422125b654cf85ace396 339 Hamap MF_01671 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase [iolG]. 5 339 47.078 T 17-03-2017 IPR023794 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase GO:0019310|GO:0050112|GO:0055114 KEGG: 00521+1.1.1.18|KEGG: 00562+1.1.1.18|MetaCyc: PWY-5940|MetaCyc: PWY-7237|MetaCyc: PWY-7241 SHXM_RS22710 38463600573cca24307f30f2133924b2 119 Gene3D G3DSA:1.10.10.10 16 72 6.8E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22710 38463600573cca24307f30f2133924b2 119 SUPERFAMILY SSF46785 16 72 2.42E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22710 38463600573cca24307f30f2133924b2 119 Pfam PF12802 MarR family 16 63 1.4E-7 T 17-03-2017 SHXM_RS41225 b1a8e766d305f28f96a2940ac9623a3f 157 SMART SM00347 33 136 6.1E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS41225 b1a8e766d305f28f96a2940ac9623a3f 157 Pfam PF12802 MarR family 44 98 1.6E-8 T 17-03-2017 SHXM_RS41225 b1a8e766d305f28f96a2940ac9623a3f 157 SUPERFAMILY SSF46785 2 149 1.86E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41225 b1a8e766d305f28f96a2940ac9623a3f 157 Gene3D G3DSA:1.10.10.10 2 152 1.0E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34335 b17f572725f88160af6997cdbe16d142 599 Pfam PF02342 TerD domain 1 170 1.3E-33 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS34335 b17f572725f88160af6997cdbe16d142 599 Gene3D G3DSA:2.60.60.30 31 167 9.4E-25 T 17-03-2017 SHXM_RS34335 b17f572725f88160af6997cdbe16d142 599 Pfam PF01987 Mitochondrial biogenesis AIM24 406 595 4.0E-23 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS34335 b17f572725f88160af6997cdbe16d142 599 Gene3D G3DSA:3.60.160.10 405 595 4.2E-28 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS34335 b17f572725f88160af6997cdbe16d142 599 SUPERFAMILY SSF51219 401 598 5.75E-33 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS26580 436cd1002f99f73f45edb546dcfc3bf0 245 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 139 155 1.3E-11 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS26580 436cd1002f99f73f45edb546dcfc3bf0 245 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 55 63 1.3E-11 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS26580 436cd1002f99f73f45edb546dcfc3bf0 245 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 100 115 1.3E-11 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS26580 436cd1002f99f73f45edb546dcfc3bf0 245 Pfam PF01252 Signal peptidase (SPase) II 17 155 3.4E-21 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS26580 436cd1002f99f73f45edb546dcfc3bf0 245 Hamap MF_00161 Lipoprotein signal peptidase [lspA]. 8 164 11.742 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS48905 98ecee558e46271a45cfa92abfac992e 252 Gene3D G3DSA:3.40.50.10310 2 243 2.2E-63 T 17-03-2017 IPR024087 Creatininase-like domain KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS48905 98ecee558e46271a45cfa92abfac992e 252 SUPERFAMILY SSF102215 3 245 7.45E-58 T 17-03-2017 IPR024087 Creatininase-like domain KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS48905 98ecee558e46271a45cfa92abfac992e 252 Pfam PF02633 Creatinine amidohydrolase 5 242 2.3E-55 T 17-03-2017 IPR003785 Creatininase/formamide hydrolase KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS16790 83c9d61f458df81c36aa86ceb7604598 216 SUPERFAMILY SSF52317 11 171 1.03E-39 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS16790 83c9d61f458df81c36aa86ceb7604598 216 Pfam PF00117 Glutamine amidotransferase class-I 18 155 1.0E-20 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS16790 83c9d61f458df81c36aa86ceb7604598 216 Gene3D G3DSA:3.40.50.880 4 201 5.0E-49 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SUPERFAMILY SSF55781 291 441 1.92E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SUPERFAMILY SSF81606 473 667 9.94E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SUPERFAMILY SSF55781 3 136 5.02E-10 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Gene3D G3DSA:3.30.450.40 4 137 8.4E-8 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 486 668 3.9E-44 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SUPERFAMILY SSF55785 156 259 5.41E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Gene3D G3DSA:3.30.450.40 265 441 3.7E-11 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SMART SM00086 223 265 0.0019 T 17-03-2017 IPR001610 PAC motif SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Pfam PF13185 GAF domain 286 428 1.0E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SUPERFAMILY SSF55874 710 780 4.76E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 SMART SM00331 455 668 4.0E-24 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Pfam PF13581 Histidine kinase-like ATPase domain 683 779 3.1E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Gene3D G3DSA:3.30.450.20 155 259 3.2E-13 T 17-03-2017 SHXM_RS14455 3ceed554cac8d036db9d7cd02b9590df 849 Pfam PF08447 PAS fold 172 259 1.5E-14 T 17-03-2017 IPR013655 PAS fold-3 GO:0005515 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 Pfam PF14759 Reductase C-terminal 332 415 5.0E-27 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 Gene3D G3DSA:3.50.50.60 15 113 6.5E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 Gene3D G3DSA:3.50.50.60 114 315 4.0E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 261 283 3.5E-25 T 17-03-2017 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 18 37 3.5E-25 T 17-03-2017 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 109 127 3.5E-25 T 17-03-2017 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 234 250 3.5E-25 T 17-03-2017 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 153 171 3.5E-25 T 17-03-2017 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 Gene3D G3DSA:3.30.390.30 332 416 5.0E-31 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 SUPERFAMILY SSF51905 9 287 6.35E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 110 118 2.5E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 271 289 2.5E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 236 257 2.5E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 149 173 2.5E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 17 39 2.5E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 17 302 4.9E-57 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18685 dc9378e2bfc060fbb36f6967347fc09d 417 SUPERFAMILY SSF55424 327 415 5.77E-28 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 Pfam PF00766 Electron transfer flavoprotein FAD-binding domain 196 278 4.4E-36 T 17-03-2017 IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal Reactome: R-HSA-611105 SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 SUPERFAMILY SSF52467 194 314 1.03E-47 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 SUPERFAMILY SSF52402 3 187 1.67E-36 T 17-03-2017 SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 Gene3D G3DSA:3.40.50.1220 190 316 6.1E-59 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 ProSitePatterns PS00696 Electron transfer flavoprotein alpha-subunit signature. 259 285 - T 17-03-2017 IPR018206 Electron transfer flavoprotein subunit alpha, conserved site Reactome: R-HSA-611105 SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 Pfam PF01012 Electron transfer flavoprotein domain 4 172 2.3E-29 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 Gene3D G3DSA:3.40.50.620 3 185 3.0E-37 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 SMART SM00893 4 183 9.8E-24 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS10605 64dcf37a2b87937914d58f70317d6eb6 320 PIRSF PIRSF000089 1 320 4.2E-99 T 17-03-2017 IPR001308 Electron transfer flavoprotein alpha subunit/FixB GO:0009055|GO:0050660 Reactome: R-HSA-611105 SHXM_RS17660 8130c3cff44a13a88f865d6161f18634 308 SUPERFAMILY SSF161098 67 295 1.24E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS17660 8130c3cff44a13a88f865d6161f18634 308 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 99 299 2.9E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS17660 8130c3cff44a13a88f865d6161f18634 308 Gene3D G3DSA:1.10.3720.10 20 297 7.9E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20515 a2999eee0fecf537fdc48a4b07e3dfd3 147 Gene3D G3DSA:3.90.190.10 55 144 1.6E-18 T 17-03-2017 IPR029021 Protein-tyrosine phosphatase-like SHXM_RS20515 a2999eee0fecf537fdc48a4b07e3dfd3 147 SUPERFAMILY SSF52799 53 144 7.62E-21 T 17-03-2017 IPR029021 Protein-tyrosine phosphatase-like SHXM_RS20515 a2999eee0fecf537fdc48a4b07e3dfd3 147 Pfam PF00102 Protein-tyrosine phosphatase 54 117 2.2E-7 T 17-03-2017 IPR000242 PTP type protein phosphatase GO:0004725|GO:0006470 SHXM_RS46600 9d0cda0d0b2a9228f59e8ef95df747e6 96 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 15 34 7.4E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46600 9d0cda0d0b2a9228f59e8ef95df747e6 96 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 36 53 7.4E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46600 9d0cda0d0b2a9228f59e8ef95df747e6 96 Gene3D G3DSA:3.40.50.720 4 58 1.3E-11 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46600 9d0cda0d0b2a9228f59e8ef95df747e6 96 SUPERFAMILY SSF51735 5 58 2.2E-11 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46600 9d0cda0d0b2a9228f59e8ef95df747e6 96 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 57 1.2E-8 T 17-03-2017 SHXM_RS47285 92cac2dd5e3e3271133ceefc38aa7267 150 Gene3D G3DSA:3.10.180.10 11 143 7.6E-26 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS47285 92cac2dd5e3e3271133ceefc38aa7267 150 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 12 138 1.2E-7 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS47285 92cac2dd5e3e3271133ceefc38aa7267 150 SUPERFAMILY SSF54593 11 146 1.34E-23 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS10875 92a7eccae8127bbe23f61068fdd58257 495 Pfam PF04616 Glycosyl hydrolases family 43 56 339 1.3E-62 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS10875 92a7eccae8127bbe23f61068fdd58257 495 Gene3D G3DSA:2.115.10.20 52 355 5.8E-76 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS10875 92a7eccae8127bbe23f61068fdd58257 495 SUPERFAMILY SSF75005 55 340 2.28E-56 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 Pfam PF10397 Adenylosuccinate lyase C-terminus 396 473 2.8E-12 T 17-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 SUPERFAMILY SSF48557 32 474 1.07E-92 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 Pfam PF00206 Lyase 39 330 6.1E-38 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 PRINTS PR00149 Fumarate lyase superfamily signature 160 178 2.7E-16 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 PRINTS PR00149 Fumarate lyase superfamily signature 115 133 2.7E-16 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 PRINTS PR00149 Fumarate lyase superfamily signature 307 323 2.7E-16 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 PRINTS PR00149 Fumarate lyase superfamily signature 262 289 2.7E-16 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 TIGRFAM TIGR02426 protocat_pcaB: 3-carboxy-cis,cis-muconate cycloisomerase 27 380 7.0E-110 T 17-03-2017 IPR012789 3-carboxy-cis,cis-muconate cycloisomerase GO:0019619|GO:0047472 KEGG: 00362+5.5.1.2 SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 Gene3D G3DSA:1.10.40.30 400 474 1.7E-18 T 17-03-2017 SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 SMART SM00998 395 474 3.0E-13 T 17-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 Gene3D G3DSA:1.20.200.10 118 399 2.5E-90 T 17-03-2017 SHXM_RS16465 67f4a64b2cf4257e6fa20b546135b919 481 Gene3D G3DSA:1.10.275.10 28 117 1.1E-26 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS38885 46647957a3a440ba629cf55661a09bb5 297 Pfam PF00388 Phosphatidylinositol-specific phospholipase C, X domain 71 184 9.0E-11 T 17-03-2017 IPR000909 Phosphatidylinositol-specific phospholipase C, X domain SHXM_RS38885 46647957a3a440ba629cf55661a09bb5 297 Gene3D G3DSA:3.20.20.190 39 294 6.9E-62 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS38885 46647957a3a440ba629cf55661a09bb5 297 SUPERFAMILY SSF51695 40 294 2.3E-48 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS38885 46647957a3a440ba629cf55661a09bb5 297 SMART SM00148 48 187 7.9E-7 T 17-03-2017 IPR000909 Phosphatidylinositol-specific phospholipase C, X domain SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 Pfam PF01189 16S rRNA methyltransferase RsmB/F 293 486 4.4E-43 T 17-03-2017 IPR001678 SAM-dependent methyltransferase RsmB/NOP2-type GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 Gene3D G3DSA:3.40.50.150 275 487 7.5E-42 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 470 487 2.0E-21 T 17-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 364 376 2.0E-21 T 17-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 298 308 2.0E-21 T 17-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 265 279 2.0E-21 T 17-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 PRINTS PR02008 RNA (C5-cytosine) methyltransferase signature 414 430 2.0E-21 T 17-03-2017 IPR023267 RNA (C5-cytosine) methyltransferase KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 SUPERFAMILY SSF53335 177 487 5.85E-51 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 ProSitePatterns PS01153 NOL1/NOP2/sun family signature. 363 374 - T 17-03-2017 IPR018314 Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, conserved site GO:0003723|GO:0008168 KEGG: 00564+2.1.1.17|MetaCyc: PWY-6825 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 Gene3D G3DSA:1.10.940.10 25 192 2.4E-46 T 17-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 SUPERFAMILY SSF48013 28 190 1.2E-33 T 17-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SHXM_RS12290 f1cfec5c581e3d97bdbedac7912db7d5 489 Pfam PF01029 NusB family 28 158 4.9E-24 T 17-03-2017 IPR006027 NusB/RsmB/TIM44 GO:0003723|GO:0006355 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Gene3D G3DSA:3.40.50.670 441 658 2.6E-88 T 17-03-2017 IPR013759 DNA topoisomerase, type IIA, central domain GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 140 154 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 62 77 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 541 558 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 523 539 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 608 624 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 457 471 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 561 573 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 97 110 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR00418 DNA topoisomerase II family signature 305 318 5.3E-66 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 60 201 6.2E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Gene3D G3DSA:3.30.230.10 254 429 7.4E-70 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 SUPERFAMILY SSF56719 431 671 2.09E-82 T 17-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 SUPERFAMILY SSF54211 255 428 2.09E-53 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 SMART SM00433 62 669 0.0 T 17-03-2017 IPR001241 DNA topoisomerase, type IIA GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 ProSitePatterns PS00177 DNA topoisomerase II signature. 459 467 - T 17-03-2017 IPR018522 DNA topoisomerase, type IIA, conserved site GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 SMART SM00387 58 202 3.0E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Hamap MF_01898 DNA gyrase subunit B [gyrB]. 30 676 88.588 T 17-03-2017 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 507 516 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 207 222 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 222 235 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 279 297 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 411 431 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 254 276 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 397 411 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 629 641 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 33 43 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 349 365 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 PRINTS PR01159 DNA gyrase subunit B signature 645 661 9.0E-75 T 17-03-2017 IPR000565 DNA topoisomerase, type IIA, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 SUPERFAMILY SSF55874 33 238 1.64E-68 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Pfam PF01751 Toprim domain 456 566 1.6E-16 T 17-03-2017 IPR006171 Toprim domain SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 TIGRFAM TIGR01059 gyrB: DNA gyrase, B subunit 33 676 1.0E-284 T 17-03-2017 IPR011557 DNA gyrase, subunit B GO:0003677|GO:0003918|GO:0005524|GO:0005694|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Gene3D G3DSA:3.30.565.10 33 238 3.9E-87 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Pfam PF00986 DNA gyrase B subunit, carboxyl terminus 607 665 1.9E-25 T 17-03-2017 IPR002288 DNA gyrase B subunit, C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 SHXM_RS28150 e7059c8ab23e13e426ded03c309e75fa 676 Pfam PF00204 DNA gyrase B 255 427 1.4E-60 T 17-03-2017 IPR013506 DNA topoisomerase, type IIA, subunit B, domain 2 GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS28050 dddfa99edc2e47a9669a1a9e52e4de5d 571 Gene3D G3DSA:2.60.120.260 440 569 6.4E-8 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS28050 dddfa99edc2e47a9669a1a9e52e4de5d 571 SUPERFAMILY SSF49785 440 570 7.51E-6 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS28050 dddfa99edc2e47a9669a1a9e52e4de5d 571 SUPERFAMILY SSF56112 87 247 3.07E-13 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS28050 dddfa99edc2e47a9669a1a9e52e4de5d 571 Gene3D G3DSA:1.10.510.10 122 210 9.9E-9 T 17-03-2017 SHXM_RS42245 5de95859d24ca19006a96a2844c75a8b 282 SUPERFAMILY SSF53474 5 280 1.73E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42245 5de95859d24ca19006a96a2844c75a8b 282 Pfam PF12697 Alpha/beta hydrolase family 8 276 2.1E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS42245 5de95859d24ca19006a96a2844c75a8b 282 Gene3D G3DSA:3.40.50.1820 6 280 4.8E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49240 0319899c6ca39fa0b7be8ac2b43cbf4a 115 SUPERFAMILY SSF56112 8 72 6.27E-11 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS49240 0319899c6ca39fa0b7be8ac2b43cbf4a 115 Gene3D G3DSA:3.90.1200.10 3 69 2.3E-12 T 17-03-2017 SHXM_RS49240 0319899c6ca39fa0b7be8ac2b43cbf4a 115 Pfam PF01636 Phosphotransferase enzyme family 4 69 5.5E-13 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 Gene3D G3DSA:3.40.50.720 12 151 6.1E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 15 125 9.6E-27 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 SUPERFAMILY SSF55347 138 340 5.12E-65 T 17-03-2017 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 Gene3D G3DSA:3.30.360.10 152 335 2.4E-71 T 17-03-2017 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 TIGRFAM TIGR01296 asd_B: aspartate-semialdehyde dehydrogenase 15 353 2.4E-116 T 17-03-2017 IPR005986 Aspartate-semialdehyde dehydrogenase, beta-type GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 PIRSF PIRSF000148 12 357 2.5E-115 T 17-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 Hamap MF_02121 Aspartate-semialdehyde dehydrogenase [asd]. 12 353 33.127 T 17-03-2017 IPR012080 Aspartate-semialdehyde dehydrogenase GO:0004073|GO:0009086|GO:0009088|GO:0009089|GO:0009097|GO:0050661|GO:0055114 KEGG: 00260+1.2.1.11|KEGG: 00261+1.2.1.11|KEGG: 00270+1.2.1.11|KEGG: 00300+1.2.1.11|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 Pfam PF02774 Semialdehyde dehydrogenase, dimerisation domain 150 339 1.3E-46 T 17-03-2017 IPR012280 Semialdehyde dehydrogenase, dimerisation domain GO:0003942|GO:0005737|GO:0008652|GO:0016620|GO:0046983|GO:0055114 KEGG: 00220+1.2.1.38|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 SMART SM00859 14 129 2.2E-33 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS27130 a384c60a6d183d1aa5c4daeb43074eee 363 SUPERFAMILY SSF51735 14 165 8.31E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20970 a2138f88e7c93fedcadcdf3c97ea115e 406 ProSitePatterns PS01136 Uncharacterized protein family UPF0034 signature. 114 132 - T 17-03-2017 IPR018517 tRNA-dihydrouridine synthase, conserved site GO:0008033|GO:0017150|GO:0050660|GO:0055114 SHXM_RS20970 a2138f88e7c93fedcadcdf3c97ea115e 406 TIGRFAM TIGR00737 nifR3_yhdG: putative TIM-barrel protein, nifR3 family 20 268 4.0E-94 T 17-03-2017 IPR004652 tRNA-dihydrouridine synthase, TIM-barrel, NifR3 GO:0008033|GO:0016491|GO:0050660|GO:0055114 SHXM_RS20970 a2138f88e7c93fedcadcdf3c97ea115e 406 Gene3D G3DSA:1.10.1200.80 290 360 1.6E-19 T 17-03-2017 IPR024036 tRNA-dihydrouridine synthase, putative, C-terminal GO:0016491|GO:0055114 SHXM_RS20970 a2138f88e7c93fedcadcdf3c97ea115e 406 Gene3D G3DSA:3.20.20.70 25 265 5.5E-83 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS20970 a2138f88e7c93fedcadcdf3c97ea115e 406 SUPERFAMILY SSF51395 27 355 6.35E-76 T 17-03-2017 SHXM_RS20970 a2138f88e7c93fedcadcdf3c97ea115e 406 Pfam PF01207 Dihydrouridine synthase (Dus) 30 353 4.4E-91 T 17-03-2017 IPR001269 tRNA-dihydrouridine synthase GO:0008033|GO:0017150|GO:0050660|GO:0055114 SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 Gene3D G3DSA:3.90.226.10 280 531 1.9E-100 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 SUPERFAMILY SSF52096 257 531 3.32E-89 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 Pfam PF01039 Carboxyl transferase domain 41 529 3.6E-194 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 142 160 4.6E-6 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 108 122 4.6E-6 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 Gene3D G3DSA:3.90.226.10 12 269 3.9E-81 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS24680 d80bb897dcc73f4900ed9c8a42f64323 531 SUPERFAMILY SSF52096 19 269 8.13E-81 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS03145 439759c390492d3f2d70f7d675641cc8 246 Gene3D G3DSA:3.40.50.880 2 245 2.0E-48 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS03145 439759c390492d3f2d70f7d675641cc8 246 Pfam PF17124 ThiJ/PfpI family-like 7 202 2.4E-38 T 17-03-2017 IPR032633 ThiJ/PfpI family-like SHXM_RS03145 439759c390492d3f2d70f7d675641cc8 246 SUPERFAMILY SSF52317 2 245 1.08E-36 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 Gene3D G3DSA:1.10.1740.10 22 97 1.8E-18 T 17-03-2017 SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 SUPERFAMILY SSF88946 23 110 1.33E-17 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 SUPERFAMILY SSF88659 123 185 2.24E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 Pfam PF04542 Sigma-70 region 2 39 96 1.8E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 53 83 - T 17-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 37 185 1.3E-28 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 Gene3D G3DSA:1.10.10.10 124 185 1.5E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26570 ac33ad7c80175e219cd24f6cc4ec5763 197 Pfam PF08281 Sigma-70, region 4 129 181 5.4E-16 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS38740 dbd2eeaa91960b3c782c4ec5fa488793 232 Gene3D G3DSA:3.40.50.620 13 204 9.9E-58 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS38740 dbd2eeaa91960b3c782c4ec5fa488793 232 PIRSF PIRSF000857 3 232 9.6E-91 T 17-03-2017 IPR004511 Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019379|GO:0055114 KEGG: 00920+1.8.4.8 SHXM_RS38740 dbd2eeaa91960b3c782c4ec5fa488793 232 SUPERFAMILY SSF52402 18 193 2.9E-49 T 17-03-2017 SHXM_RS38740 dbd2eeaa91960b3c782c4ec5fa488793 232 TIGRFAM TIGR00434 cysH: phosophoadenylyl-sulfate reductase 26 231 4.0E-58 T 17-03-2017 IPR004511 Phosphoadenosine phosphosulphate/adenosine 5'-phosphosulphate reductase GO:0004604|GO:0019379|GO:0055114 KEGG: 00920+1.8.4.8 SHXM_RS38740 dbd2eeaa91960b3c782c4ec5fa488793 232 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 45 207 4.2E-43 T 17-03-2017 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 Reactome: R-HSA-196843 SHXM_RS36135 796b4a3bc1cad145346a1e398ae35e74 397 Gene3D G3DSA:2.120.10.30 72 395 5.6E-88 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS36135 796b4a3bc1cad145346a1e398ae35e74 397 Pfam PF07995 Glucose / Sorbosone dehydrogenase 81 381 2.1E-73 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS36135 796b4a3bc1cad145346a1e398ae35e74 397 SUPERFAMILY SSF50952 63 381 7.98E-46 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS23275 e27d95e5ac2f3947b4c731b62f112136 62 Pfam PF14013 MT0933-like antitoxin protein 4 52 6.0E-16 T 17-03-2017 IPR028037 Antitoxin Rv0909/MT0933 SHXM_RS36475 0287e1023622ea8d4b685002f480a101 93 Pfam PF00708 Acylphosphatase 5 93 3.0E-21 T 17-03-2017 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SHXM_RS36475 0287e1023622ea8d4b685002f480a101 93 ProSitePatterns PS00150 Acylphosphatase signature 1. 11 21 - T 17-03-2017 IPR017968 Acylphosphatase, conserved site KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SHXM_RS36475 0287e1023622ea8d4b685002f480a101 93 Gene3D G3DSA:3.30.70.100 5 93 2.0E-26 T 17-03-2017 SHXM_RS36475 0287e1023622ea8d4b685002f480a101 93 SUPERFAMILY SSF54975 3 93 2.4E-23 T 17-03-2017 IPR001792 Acylphosphatase-like domain KEGG: 00620+3.6.1.7|KEGG: 00627+3.6.1.7 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 Gene3D G3DSA:1.10.630.10 4 399 2.8E-83 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 PRINTS PR00359 B-class P450 signature 195 217 4.4E-22 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 PRINTS PR00359 B-class P450 signature 291 318 4.4E-22 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 PRINTS PR00359 B-class P450 signature 144 160 4.4E-22 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 PRINTS PR00359 B-class P450 signature 161 176 4.4E-22 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 PRINTS PR00359 B-class P450 signature 338 347 4.4E-22 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 PRINTS PR00359 B-class P450 signature 98 109 4.4E-22 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 SUPERFAMILY SSF48264 4 398 4.98E-60 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20705 cae2950a8db94fcfb6b80dccca43ce13 462 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 340 349 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS01315 ea058d5d654d48cf3a07daed9d44766f 357 Gene3D G3DSA:3.40.50.720 170 320 1.8E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01315 ea058d5d654d48cf3a07daed9d44766f 357 Gene3D G3DSA:3.90.180.10 2 82 1.1E-20 T 17-03-2017 IPR011032 GroES-like SHXM_RS01315 ea058d5d654d48cf3a07daed9d44766f 357 Gene3D G3DSA:3.90.180.10 114 169 1.1E-20 T 17-03-2017 IPR011032 GroES-like SHXM_RS01315 ea058d5d654d48cf3a07daed9d44766f 357 SUPERFAMILY SSF50129 3 178 2.74E-25 T 17-03-2017 IPR011032 GroES-like SHXM_RS01315 ea058d5d654d48cf3a07daed9d44766f 357 SUPERFAMILY SSF51735 153 320 1.78E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01315 ea058d5d654d48cf3a07daed9d44766f 357 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 21 133 8.0E-8 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 Pfam PF02779 Transketolase, pyrimidine binding domain 304 463 6.4E-35 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 SUPERFAMILY SSF52518 4 266 1.79E-77 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 Pfam PF02780 Transketolase, C-terminal domain 481 600 2.6E-28 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 Gene3D G3DSA:3.40.50.970 3 261 7.7E-82 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 Gene3D G3DSA:3.40.50.920 478 608 4.2E-33 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 SMART SM00861 304 467 2.1E-42 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 Gene3D G3DSA:3.40.50.970 299 477 3.3E-55 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 SUPERFAMILY SSF52518 294 469 3.11E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 ProSitePatterns PS00802 Transketolase signature 2. 410 426 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 SUPERFAMILY SSF52922 475 608 3.4E-29 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS07140 bbcde4196162a6523ae7f1851ba3bd5d 612 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 11 260 8.3E-45 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS10495 2fde9c7803a0697d60387748fa3380e8 215 Gene3D G3DSA:3.40.50.1000 2 208 1.6E-30 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS10495 2fde9c7803a0697d60387748fa3380e8 215 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 96 172 7.5E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS10495 2fde9c7803a0697d60387748fa3380e8 215 SUPERFAMILY SSF56784 3 206 1.03E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS10495 2fde9c7803a0697d60387748fa3380e8 215 Pfam PF00702 haloacid dehalogenase-like hydrolase 31 172 7.8E-11 T 17-03-2017 SHXM_RS10885 4000bd6a5e52207e7cbbbad62df7f684 204 SUPERFAMILY SSF54909 1 98 2.17E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS10885 4000bd6a5e52207e7cbbbad62df7f684 204 Pfam PF07978 NIPSNAP 108 201 3.9E-10 T 17-03-2017 IPR012577 NIPSNAP SHXM_RS10885 4000bd6a5e52207e7cbbbad62df7f684 204 SUPERFAMILY SSF54909 101 201 1.96E-16 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS10885 4000bd6a5e52207e7cbbbad62df7f684 204 Gene3D G3DSA:3.30.70.900 97 201 1.9E-10 T 17-03-2017 SHXM_RS10885 4000bd6a5e52207e7cbbbad62df7f684 204 Gene3D G3DSA:3.30.70.900 1 73 7.7E-5 T 17-03-2017 SHXM_RS38370 ad2780e4567e231ed5d9d45d6ebded91 256 Gene3D G3DSA:1.20.120.450 2 142 4.8E-4 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS38370 ad2780e4567e231ed5d9d45d6ebded91 256 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 4 139 5.2E-21 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS38370 ad2780e4567e231ed5d9d45d6ebded91 256 TIGRFAM TIGR03084 TIGR03084: TIGR03084 family protein 1 249 1.7E-86 T 17-03-2017 IPR017518 Conserved hypothetical protein CHP03084 SHXM_RS38370 ad2780e4567e231ed5d9d45d6ebded91 256 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 5 216 5.7E-36 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS38370 ad2780e4567e231ed5d9d45d6ebded91 256 SUPERFAMILY SSF109854 2 142 5.95E-22 T 17-03-2017 SHXM_RS17650 96ecebd7f0e888230c98ca7436e6b048 404 Gene3D G3DSA:3.30.360.10 158 340 6.5E-19 T 17-03-2017 SHXM_RS17650 96ecebd7f0e888230c98ca7436e6b048 404 SUPERFAMILY SSF51735 12 168 2.96E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17650 96ecebd7f0e888230c98ca7436e6b048 404 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 20 140 1.0E-12 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS17650 96ecebd7f0e888230c98ca7436e6b048 404 SUPERFAMILY SSF55347 150 305 2.4E-13 T 17-03-2017 SHXM_RS17650 96ecebd7f0e888230c98ca7436e6b048 404 Gene3D G3DSA:3.40.50.720 13 157 1.3E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13765 aebef0f7dcdcb3bde6f2b43837b98488 209 PIRSF PIRSF001296 8 209 6.8E-68 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS13765 aebef0f7dcdcb3bde6f2b43837b98488 209 TIGRFAM TIGR00681 kdpC: K+-transporting ATPase, C subunit 13 206 1.7E-52 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS13765 aebef0f7dcdcb3bde6f2b43837b98488 209 Pfam PF02669 K+-transporting ATPase, c chain 14 206 5.4E-68 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS13765 aebef0f7dcdcb3bde6f2b43837b98488 209 Hamap MF_00276 Potassium-transporting ATPase KdpC subunit [kdpC]. 9 208 34.271 T 17-03-2017 IPR003820 Potassium-transporting ATPase C chain GO:0006813|GO:0008556|GO:0016021 SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 SUPERFAMILY SSF52172 7 175 9.81E-41 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 Gene3D G3DSA:3.40.50.2300 7 126 1.0E-40 T 17-03-2017 SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 224 1.2E-24 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 Pfam PF00072 Response regulator receiver domain 8 115 8.5E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 SMART SM00448 5 115 2.2E-40 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 SMART SM00862 148 224 1.0E-22 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS24790 697471329736ad88af1f684e6f800c8f 227 Gene3D G3DSA:1.10.10.10 127 226 7.1E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13400 45a71f25eb4ae2c0532b80aaee2af73a 275 Pfam PF01614 Bacterial transcriptional regulator 148 256 1.5E-11 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS13400 45a71f25eb4ae2c0532b80aaee2af73a 275 SUPERFAMILY SSF46785 13 82 8.84E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13400 45a71f25eb4ae2c0532b80aaee2af73a 275 SUPERFAMILY SSF55781 76 256 8.5E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS13400 45a71f25eb4ae2c0532b80aaee2af73a 275 Gene3D G3DSA:1.10.10.10 8 78 5.9E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13400 45a71f25eb4ae2c0532b80aaee2af73a 275 Gene3D G3DSA:3.30.450.40 79 243 1.5E-23 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS15810 2437b42a780d1745de65791d9e1ef786 245 Gene3D G3DSA:3.40.50.1980 8 106 8.3E-19 T 17-03-2017 SHXM_RS15810 2437b42a780d1745de65791d9e1ef786 245 Gene3D G3DSA:3.40.50.1980 132 241 1.9E-10 T 17-03-2017 SHXM_RS15810 2437b42a780d1745de65791d9e1ef786 245 SUPERFAMILY SSF53807 6 241 3.06E-30 T 17-03-2017 SHXM_RS49040 b55e22718d1710c1969db96f26dae2e8 469 Gene3D G3DSA:3.40.605.10 5 245 3.8E-75 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS49040 b55e22718d1710c1969db96f26dae2e8 469 Pfam PF00171 Aldehyde dehydrogenase family 5 454 2.2E-137 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS49040 b55e22718d1710c1969db96f26dae2e8 469 SUPERFAMILY SSF53720 6 457 2.36E-141 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS49040 b55e22718d1710c1969db96f26dae2e8 469 Gene3D G3DSA:3.40.309.10 246 434 2.1E-57 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS42665 000523d7e23133880f402fe39e002294 269 Gene3D G3DSA:1.10.3720.10 64 259 2.0E-27 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42665 000523d7e23133880f402fe39e002294 269 SUPERFAMILY SSF161098 66 252 3.14E-34 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42665 000523d7e23133880f402fe39e002294 269 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 89 257 1.8E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48150 e34b79b9f5a877b6fb760fc2ecbef2d9 341 SUPERFAMILY SSF51445 141 284 4.96E-14 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS48150 e34b79b9f5a877b6fb760fc2ecbef2d9 341 SUPERFAMILY SSF51445 15 113 4.96E-14 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS48150 e34b79b9f5a877b6fb760fc2ecbef2d9 341 Gene3D G3DSA:3.20.20.80 124 293 4.6E-6 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS47665 5d0710f64d0f7b9bca30b696917c923a 289 Pfam PF01774 UreD urease accessory protein 85 238 1.1E-24 T 17-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 SHXM_RS47665 5d0710f64d0f7b9bca30b696917c923a 289 Hamap MF_01384 Urease accessory protein UreD [ureD]. 40 287 19.495 T 17-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 SHXM_RS33515 bd52d02c5a9ab905a566eaa92e5d2459 253 Hamap MF_01139 Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) [uppS]. 24 253 36.129 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS33515 bd52d02c5a9ab905a566eaa92e5d2459 253 Gene3D G3DSA:3.40.1180.10 11 252 5.9E-87 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS33515 bd52d02c5a9ab905a566eaa92e5d2459 253 Pfam PF01255 Putative undecaprenyl diphosphate synthase 31 252 1.3E-70 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS33515 bd52d02c5a9ab905a566eaa92e5d2459 253 TIGRFAM TIGR00055 uppS: di-trans,poly-cis-decaprenylcistransferase 24 252 4.4E-65 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS33515 bd52d02c5a9ab905a566eaa92e5d2459 253 SUPERFAMILY SSF64005 19 247 4.19E-74 T 17-03-2017 IPR001441 Decaprenyl diphosphate synthase-like GO:0016765 Reactome: R-HSA-446199 SHXM_RS33515 bd52d02c5a9ab905a566eaa92e5d2459 253 ProSitePatterns PS01066 Undecaprenyl pyrophosphate synthase family signature. 198 215 - T 17-03-2017 IPR018520 Di-trans-poly-cis-decaprenylcistransferase-like, conserved site GO:0016765 Reactome: R-HSA-446199|Reactome: R-HSA-4755609 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 243 274 10.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 275 306 21.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 211 242 81.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 162 210 250.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 307 338 14.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 99 130 0.24 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 339 370 18.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 371 402 0.27 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 529 560 2.7 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 131 161 9.3 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 67 98 180.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SMART SM00671 497 528 9.7 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SUPERFAMILY SSF81901 196 313 1.57E-18 T 17-03-2017 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF13432 Tetratricopeptide repeat 488 529 0.0037 T 17-03-2017 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF07721 Tetratricopeptide repeat 277 299 1.0 T 17-03-2017 IPR011717 Tetratricopeptide TPR-4 GO:0042802 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF07721 Tetratricopeptide repeat 310 332 0.0029 T 17-03-2017 IPR011717 Tetratricopeptide TPR-4 GO:0042802 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF07721 Tetratricopeptide repeat 36 59 0.017 T 17-03-2017 IPR011717 Tetratricopeptide TPR-4 GO:0042802 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Gene3D G3DSA:1.25.40.10 196 382 9.4E-40 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Gene3D G3DSA:1.25.40.10 24 174 2.8E-26 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Gene3D G3DSA:1.25.40.10 388 607 4.1E-32 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF08238 Sel1 repeat 245 274 19.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF08238 Sel1 repeat 99 130 0.74 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF08238 Sel1 repeat 544 560 6.7 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF08238 Sel1 repeat 146 161 4.9 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF08238 Sel1 repeat 358 370 21.0 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF08238 Sel1 repeat 163 210 0.038 T 17-03-2017 IPR006597 Sel1-like repeat SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SUPERFAMILY SSF81901 483 594 6.15E-19 T 17-03-2017 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SUPERFAMILY SSF81901 29 169 7.24E-16 T 17-03-2017 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 Pfam PF13374 Tetratricopeptide repeat 376 400 0.0052 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34395 71ec49947c24ccbf837c0b91c4fa8b5d 612 SUPERFAMILY SSF81901 281 442 1.05E-24 T 17-03-2017 SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 Pfam PF00145 C-5 cytosine-specific DNA methylase 5 165 2.4E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 105 119 9.5E-6 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 147 160 9.5E-6 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 5 21 9.5E-6 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 SUPERFAMILY SSF53335 4 227 4.15E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 SUPERFAMILY SSF53335 329 389 4.15E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 Gene3D G3DSA:3.40.50.150 2 165 1.3E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29515 5fce0f2676bcb7f34638ab799e08a53c 405 ProSitePatterns PS00094 C-5 cytosine-specific DNA methylases active site. 67 79 - T 17-03-2017 IPR018117 DNA methylase, C-5 cytosine-specific, active site KEGG: 00270+2.1.1.37|Reactome: R-HSA-212300|Reactome: R-HSA-5334118 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 SUPERFAMILY SSF52374 392 646 3.49E-120 T 17-03-2017 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 SUPERFAMILY SSF52374 8 201 3.49E-120 T 17-03-2017 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 SUPERFAMILY SSF50677 204 392 6.38E-45 T 17-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 SUPERFAMILY SSF47323 653 887 3.92E-48 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Pfam PF08264 Anticodon-binding domain of tRNA 685 830 4.4E-29 T 17-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Pfam PF00133 tRNA synthetases class I (I, L, M and V) 21 626 2.5E-165 T 17-03-2017 IPR002300 Aminoacyl-tRNA synthetase, class Ia GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Gene3D G3DSA:3.40.50.620 395 633 2.6E-132 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Gene3D G3DSA:3.40.50.620 8 197 2.6E-132 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Hamap MF_02003 Isoleucine--tRNA ligase [ileS]. 6 1043 13.685 T 17-03-2017 IPR023586 Isoleucine-tRNA ligase, type 2 GO:0004822 KEGG: 00970+6.1.1.5|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 TIGRFAM TIGR00392 ileS: isoleucine--tRNA ligase 8 836 9.2E-265 T 17-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 557 566 3.3E-26 T 17-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 227 250 3.3E-26 T 17-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 44 55 3.3E-26 T 17-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 390 405 3.3E-26 T 17-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 PRINTS PR00984 Isoleucyl-tRNA synthetase signature 517 530 3.3E-26 T 17-03-2017 IPR002301 Isoleucine-tRNA ligase GO:0000166|GO:0004822|GO:0005524|GO:0005737|GO:0006428 KEGG: 00970+6.1.1.5 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Gene3D G3DSA:1.10.730.10 644 821 6.6E-46 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS18525 495e9543dc92df7c5556a31552f6105f 1045 Gene3D G3DSA:3.90.740.10 206 378 2.1E-49 T 17-03-2017 IPR009008 Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain GO:0002161|GO:0006418 SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 SMART SM01011 41 199 2.5E-26 T 17-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 SUPERFAMILY SSF55920 187 453 3.53E-58 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 Gene3D G3DSA:3.90.230.10 185 454 4.0E-61 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 Pfam PF00557 Metallopeptidase family M24 194 432 1.4E-45 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 Gene3D G3DSA:3.40.350.10 47 157 1.6E-22 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 Pfam PF05195 Aminopeptidase P, N-terminal domain 48 155 7.1E-17 T 17-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 SHXM_RS44735 936849e04baa8cc1b22adba1153cadd7 461 SUPERFAMILY SSF53092 44 186 5.75E-21 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS46875 e439071f74ee35449603893aa3614663 340 Gene3D G3DSA:2.115.10.20 87 156 1.2E-6 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46875 e439071f74ee35449603893aa3614663 340 Gene3D G3DSA:2.115.10.20 157 329 1.5E-7 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46875 e439071f74ee35449603893aa3614663 340 SUPERFAMILY SSF75005 81 259 1.26E-15 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46855 53c7ab7e2aab7098fb93a2dcf1b96358 532 Pfam PF12831 FAD dependent oxidoreductase 6 506 1.3E-110 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46855 53c7ab7e2aab7098fb93a2dcf1b96358 532 SUPERFAMILY SSF51905 440 501 5.76E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46855 53c7ab7e2aab7098fb93a2dcf1b96358 532 SUPERFAMILY SSF51905 5 190 5.76E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46855 53c7ab7e2aab7098fb93a2dcf1b96358 532 SUPERFAMILY SSF51905 234 242 5.76E-22 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46855 53c7ab7e2aab7098fb93a2dcf1b96358 532 Gene3D G3DSA:3.50.50.60 4 239 5.1E-20 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46855 53c7ab7e2aab7098fb93a2dcf1b96358 532 Gene3D G3DSA:3.50.50.60 419 506 5.1E-20 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 SUPERFAMILY SSF50129 1 182 2.13E-33 T 17-03-2017 IPR011032 GroES-like SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 34 143 4.3E-12 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 Gene3D G3DSA:3.40.50.720 183 296 2.0E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 SUPERFAMILY SSF51735 150 315 2.06E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 Gene3D G3DSA:3.90.180.10 5 182 9.3E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 177 198 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 SMART SM00829 16 347 4.3E-15 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS39840 4255b00c1953d0d902ad42c222efd992 349 Pfam PF00107 Zinc-binding dehydrogenase 188 309 3.4E-24 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature. 45 64 - T 17-03-2017 IPR020816 Histone-like DNA-binding protein, conserved site GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 SMART SM00411 1 89 8.7E-38 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 Pfam PF00216 Bacterial DNA-binding protein 1 88 1.7E-23 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 Gene3D G3DSA:4.10.520.10 1 89 2.3E-27 T 17-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 SUPERFAMILY SSF47729 1 92 1.37E-24 T 17-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 PRINTS PR01727 Prokaryotic integration host factor signature 73 87 2.2E-13 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 PRINTS PR01727 Prokaryotic integration host factor signature 57 70 2.2E-13 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS36370 2a14212d766f3e1f7d9e278cee9c0bc3 190 PRINTS PR01727 Prokaryotic integration host factor signature 39 54 2.2E-13 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS34990 eafe9cd2d1cc71fe39751d09f241223e 131 Pfam PF04248 Domain of unknown function (DUF427) 27 122 3.0E-33 T 17-03-2017 IPR007361 Domain of unknown function DUF427 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 SUPERFAMILY SSF52317 5 191 8.82E-46 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 80 96 3.9E-6 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 49 63 3.9E-6 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 TIGRFAM TIGR00553 pabB: aminodeoxychorismate synthase, component I 373 728 2.3E-103 T 17-03-2017 IPR005802 Para-aminobenzoate synthase, component I GO:0009396 KEGG: 00790+2.6.1.85|MetaCyc: PWY-6543 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 Gene3D G3DSA:3.40.50.880 5 193 3.4E-58 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 Pfam PF00117 Glutamine amidotransferase class-I 8 189 4.7E-39 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 TIGRFAM TIGR00566 trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase 7 189 1.6E-43 T 17-03-2017 IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain GO:0008152 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 Gene3D G3DSA:3.60.120.10 265 736 1.2E-152 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00097 Anthranilate synthase component II signature 52 61 6.1E-27 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00097 Anthranilate synthase component II signature 6 20 6.1E-27 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00097 Anthranilate synthase component II signature 125 137 6.1E-27 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00097 Anthranilate synthase component II signature 80 91 6.1E-27 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00097 Anthranilate synthase component II signature 169 182 6.1E-27 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00097 Anthranilate synthase component II signature 105 113 6.1E-27 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 Pfam PF00425 chorismate binding enzyme 472 726 1.1E-91 T 17-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 SUPERFAMILY SSF56322 263 734 6.93E-133 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 Pfam PF04715 Anthranilate synthase component I, N terminal region 277 417 4.2E-21 T 17-03-2017 IPR006805 Anthranilate synthase component I, N-terminal GO:0009058|GO:0016833 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00096 Glutamine amidotransferase superfamily signature 52 61 2.1E-12 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00096 Glutamine amidotransferase superfamily signature 169 182 2.1E-12 T 17-03-2017 SHXM_RS06665 b40fab36afa126ac0dfc11cd20a10160 770 PRINTS PR00096 Glutamine amidotransferase superfamily signature 80 91 2.1E-12 T 17-03-2017 SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 SMART SM00862 145 220 4.7E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 220 1.3E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 Gene3D G3DSA:3.40.50.2300 2 120 7.8E-39 T 17-03-2017 SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 SMART SM00448 1 112 1.4E-42 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 Pfam PF00072 Response regulator receiver domain 3 112 2.1E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 Gene3D G3DSA:1.10.10.10 124 221 1.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20675 40b8b302bc6c3c88df25bc9dbbd1e7cb 225 SUPERFAMILY SSF52172 2 180 5.42E-39 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 SUPERFAMILY SSF52540 306 553 7.99E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 Pfam PF00005 ABC transporter 33 190 5.8E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 Pfam PF00005 ABC transporter 332 481 3.3E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 241 280 3.7E-5 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 533 558 1.8E-5 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 ProSitePatterns PS00211 ABC transporters family signature. 454 468 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 SMART SM00382 41 239 3.3E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 SMART SM00382 341 531 3.6E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 SUPERFAMILY SSF52540 12 261 5.93E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 Gene3D G3DSA:3.40.50.300 304 554 4.7E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01930 797ce1718a5c453c89906b0ca5bc1c9f 565 Gene3D G3DSA:3.40.50.300 11 263 2.1E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 SMART SM00411 1 91 6.8E-37 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 Gene3D G3DSA:4.10.520.10 1 91 2.2E-28 T 17-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 PRINTS PR01727 Prokaryotic integration host factor signature 59 72 1.8E-8 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 PRINTS PR01727 Prokaryotic integration host factor signature 41 56 1.8E-8 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 PRINTS PR01727 Prokaryotic integration host factor signature 75 89 1.8E-8 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 ProSitePatterns PS00045 Bacterial histone-like DNA-binding proteins signature. 47 66 - T 17-03-2017 IPR020816 Histone-like DNA-binding protein, conserved site GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 Pfam PF00216 Bacterial DNA-binding protein 1 90 1.2E-27 T 17-03-2017 IPR000119 Histone-like DNA-binding protein GO:0003677 SHXM_RS23695 e6cf3fb3c8d3a06b699ce736e76cc4d7 93 SUPERFAMILY SSF47729 1 91 4.86E-26 T 17-03-2017 IPR010992 Integration host factor (IHF)-like DNA-binding domain GO:0003677 SHXM_RS45275 eeae08f42c4220e794ad7ba1474972f4 654 Gene3D G3DSA:2.120.10.30 113 230 1.4E-6 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS45275 eeae08f42c4220e794ad7ba1474972f4 654 SUPERFAMILY SSF63825 77 215 3.4E-8 T 17-03-2017 SHXM_RS45275 eeae08f42c4220e794ad7ba1474972f4 654 TIGRFAM TIGR02242 tail_TIGR02242: phage tail protein domain 382 488 2.0E-22 T 17-03-2017 IPR011748 Uncharacterised protein family, phage tail-like SHXM_RS45275 eeae08f42c4220e794ad7ba1474972f4 654 Pfam PF09684 Phage tail protein (Tail_P2_I) 405 498 3.5E-15 T 17-03-2017 IPR006521 Tail protein I SHXM_RS32155 2b75314ebc7ddff0a7153df286cc9d8c 104 Pfam PF01610 Transposase 26 100 1.8E-8 T 17-03-2017 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SHXM_RS33375 3bafe4eee9eebb18d41ff7b7b23158df 137 Gene3D G3DSA:3.30.1330.40 6 136 1.5E-33 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS33375 3bafe4eee9eebb18d41ff7b7b23158df 137 SUPERFAMILY SSF55298 4 137 3.14E-30 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS33375 3bafe4eee9eebb18d41ff7b7b23158df 137 Pfam PF01042 Endoribonuclease L-PSP 18 135 9.6E-25 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS03260 149563b5559ceff972aeed32750ddb85 258 SUPERFAMILY SSF52540 1 229 2.66E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03260 149563b5559ceff972aeed32750ddb85 258 Pfam PF00005 ABC transporter 18 159 3.4E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS03260 149563b5559ceff972aeed32750ddb85 258 Gene3D G3DSA:3.40.50.300 1 208 3.7E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03260 149563b5559ceff972aeed32750ddb85 258 ProSitePatterns PS00211 ABC transporters family signature. 132 146 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS03260 149563b5559ceff972aeed32750ddb85 258 SMART SM00382 27 209 1.5E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS13060 d4498b1deeb255b5c171f245a22d44ce 760 SUPERFAMILY SSF110296 36 441 9.42E-86 T 17-03-2017 SHXM_RS13060 d4498b1deeb255b5c171f245a22d44ce 760 SUPERFAMILY SSF110296 448 758 2.49E-42 T 17-03-2017 SHXM_RS13060 d4498b1deeb255b5c171f245a22d44ce 760 Gene3D G3DSA:2.130.10.140 498 756 4.0E-41 T 17-03-2017 SHXM_RS13060 d4498b1deeb255b5c171f245a22d44ce 760 Gene3D G3DSA:2.130.10.140 45 483 1.5E-79 T 17-03-2017 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 184 1.5E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 184 200 1.5E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 200 212 1.5E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 Pfam PF00072 Response regulator receiver domain 17 130 7.1E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 SMART SM00421 167 224 7.8E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 SMART SM00448 15 129 5.2E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 Gene3D G3DSA:1.10.10.10 170 229 8.1E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 Pfam PF00196 Bacterial regulatory proteins, luxR family 169 223 2.5E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 Gene3D G3DSA:3.40.50.2300 13 169 8.8E-39 T 17-03-2017 SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 SUPERFAMILY SSF52172 13 195 3.08E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS17620 68efbb1b376296da6f7e8c07ecccc4a8 233 ProSitePatterns PS00622 LuxR-type HTH domain signature. 184 211 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38570 9221cff83f60f5093a749b6c37095e5d 210 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 4 92 3.9E-15 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS38570 9221cff83f60f5093a749b6c37095e5d 210 Gene3D G3DSA:3.40.50.720 4 202 2.0E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38570 9221cff83f60f5093a749b6c37095e5d 210 SUPERFAMILY SSF51735 4 190 1.85E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02770 1d2b09de616e8a7339b71178e8e4f00b 189 SUPERFAMILY SSF48498 78 181 4.45E-21 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS02770 1d2b09de616e8a7339b71178e8e4f00b 189 SUPERFAMILY SSF46689 5 72 1.4E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02770 1d2b09de616e8a7339b71178e8e4f00b 189 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 46 8.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS02770 1d2b09de616e8a7339b71178e8e4f00b 189 Pfam PF13305 WHG domain 83 159 7.6E-7 T 17-03-2017 IPR025996 WHG domain SHXM_RS02770 1d2b09de616e8a7339b71178e8e4f00b 189 Gene3D G3DSA:1.10.357.10 51 184 9.6E-42 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS02770 1d2b09de616e8a7339b71178e8e4f00b 189 Gene3D G3DSA:1.10.10.60 2 49 4.9E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 Gene3D G3DSA:3.30.70.141 21 167 3.3E-18 T 17-03-2017 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 Gene3D G3DSA:3.30.70.141 178 325 5.5E-18 T 17-03-2017 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 SMART SM00562 21 171 2.0E-6 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 SUPERFAMILY SSF54919 178 325 1.3E-21 T 17-03-2017 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 SUPERFAMILY SSF54919 20 166 1.96E-21 T 17-03-2017 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 Pfam PF00334 Nucleoside diphosphate kinase 21 166 3.8E-16 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS10240 aeeb03c663e146ad45bc1125af549c1a 346 Pfam PF00334 Nucleoside diphosphate kinase 179 325 6.4E-16 T 17-03-2017 IPR001564 Nucleoside diphosphate kinase GO:0004550|GO:0006165|GO:0006183|GO:0006228|GO:0006241 KEGG: 00230+2.7.4.6|KEGG: 00240+2.7.4.6|MetaCyc: PWY-6545|MetaCyc: PWY-7176|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7197|MetaCyc: PWY-7198|MetaCyc: PWY-7205|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7221|MetaCyc: PWY-7222|MetaCyc: PWY-7224|MetaCyc: PWY-7226|MetaCyc: PWY-7227 SHXM_RS15360 de7b3a6d456ca08fef5782d461bc8d58 135 Pfam PF12680 SnoaL-like domain 4 112 5.0E-11 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS15360 de7b3a6d456ca08fef5782d461bc8d58 135 Gene3D G3DSA:3.10.450.50 3 129 3.7E-30 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS15360 de7b3a6d456ca08fef5782d461bc8d58 135 SUPERFAMILY SSF54427 3 127 3.47E-23 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Gene3D G3DSA:2.30.38.10 417 494 1.4E-11 T 17-03-2017 SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Pfam PF13193 AMP-binding enzyme C-terminal domain 510 588 5.9E-26 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Gene3D G3DSA:3.40.50.980 54 240 1.7E-39 T 17-03-2017 SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Gene3D G3DSA:3.40.50.980 241 404 2.6E-29 T 17-03-2017 SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 ProSitePatterns PS00455 Putative AMP-binding domain signature. 236 247 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 SUPERFAMILY SSF56801 4 622 2.88E-163 T 17-03-2017 SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Pfam PF00501 AMP-binding enzyme 64 500 2.4E-87 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 4 58 1.7E-19 T 17-03-2017 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118 SHXM_RS41725 cd6fc13f3002d391b0b2d72a244a44d2 625 Gene3D G3DSA:3.30.300.30 496 622 1.7E-24 T 17-03-2017 SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Gene3D G3DSA:2.60.120.260 412 592 1.5E-22 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Gene3D G3DSA:3.40.50.300 625 855 1.8E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 SMART SM00939 364 597 5.6E-28 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 83 324 1.1E-17 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Pfam PF00005 ABC transporter 652 792 1.7E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Gene3D G3DSA:3.40.50.1820 265 372 9.1E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Gene3D G3DSA:3.40.50.1820 40 188 9.1E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 SUPERFAMILY SSF53474 268 376 1.24E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 SUPERFAMILY SSF53474 36 184 1.24E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 SMART SM00382 660 849 5.2E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 SUPERFAMILY SSF49785 407 582 4.04E-26 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 SUPERFAMILY SSF52540 622 856 2.01E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 ProSitePatterns PS00211 ABC transporters family signature. 764 778 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS06310 45f1591d6105120c08016cc0acf21bf8 934 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 466 571 9.9E-15 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS36495 fa5c6b89b5530bab3354c3448b273659 328 Pfam PF00296 Luciferase-like monooxygenase 16 261 1.8E-34 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS36495 fa5c6b89b5530bab3354c3448b273659 328 SUPERFAMILY SSF51679 7 327 2.62E-57 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS36495 fa5c6b89b5530bab3354c3448b273659 328 Gene3D G3DSA:3.20.20.30 6 327 9.5E-68 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48285 19ad3ab45e16a90ec70f408e2abd21bd 161 Pfam PF13586 Transposase DDE domain 49 121 3.6E-9 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS35240 e9c361d4a4f90fd809ec14afcb4f6730 187 Gene3D G3DSA:1.20.5.620 76 135 9.6E-12 T 17-03-2017 IPR028987 F-type ATP synthase subunit B-like, membrane domain SHXM_RS35240 e9c361d4a4f90fd809ec14afcb4f6730 187 SUPERFAMILY SSF81573 76 134 2.35E-10 T 17-03-2017 IPR028987 F-type ATP synthase subunit B-like, membrane domain SHXM_RS35240 e9c361d4a4f90fd809ec14afcb4f6730 187 TIGRFAM TIGR01144 ATP_synt_b: ATP synthase F0, B subunit 24 170 4.6E-26 T 17-03-2017 IPR005864 ATPase, F0 complex, subunit B, bacterial GO:0015078|GO:0015986|GO:0045263 SHXM_RS35240 e9c361d4a4f90fd809ec14afcb4f6730 187 Pfam PF00430 ATP synthase B/B' CF(0) 20 149 1.8E-27 T 17-03-2017 IPR002146 ATPase, F0 complex, subunit B/B', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 SHXM_RS35240 e9c361d4a4f90fd809ec14afcb4f6730 187 Hamap MF_01398 ATP synthase subunit b [atpF]. 4 170 12.03 T 17-03-2017 IPR002146 ATPase, F0 complex, subunit B/B', bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 SMART SM00862 305 375 3.2E-13 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 Pfam PF00486 Transcriptional regulatory protein, C terminal 311 375 2.0E-12 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 Gene3D G3DSA:3.40.50.10090 17 146 1.5E-32 T 17-03-2017 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 Gene3D G3DSA:3.40.50.10090 147 283 5.2E-36 T 17-03-2017 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 SUPERFAMILY SSF46894 290 375 1.59E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 Gene3D G3DSA:1.10.10.10 292 376 2.9E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 Pfam PF02602 Uroporphyrinogen-III synthase HemD 32 274 2.9E-42 T 17-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS23735 2eab8954f79adf816df29cc14f712767 388 SUPERFAMILY SSF69618 20 281 1.57E-56 T 17-03-2017 IPR003754 Tetrapyrrole biosynthesis, uroporphyrinogen III synthase GO:0004852|GO:0033014 KEGG: 00860+4.2.1.75|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 Gene3D G3DSA:2.40.280.10 8 128 6.9E-54 T 17-03-2017 IPR023620 Small protein B SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 Pfam PF01668 SmpB protein 9 72 2.3E-31 T 17-03-2017 IPR000037 SsrA-binding protein GO:0003723 SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 TIGRFAM TIGR00086 smpB: SsrA-binding protein 10 150 2.0E-57 T 17-03-2017 IPR000037 SsrA-binding protein GO:0003723 SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 SUPERFAMILY SSF74982 3 133 1.7E-54 T 17-03-2017 IPR023620 Small protein B SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 ProSitePatterns PS01317 SsrA-binding protein. 28 40 - T 17-03-2017 IPR020081 SsrA-binding protein, conserved site SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 Hamap MF_00023 SsrA-binding protein [smpB]. 1 159 76.638 T 17-03-2017 IPR000037 SsrA-binding protein GO:0003723 SHXM_RS23835 1cd9aef79da332c3a791db27a5000216 159 ProDom PD004488 SSRA-BINDING RNA-BINDING SMPB SMALL B TMRNA-BINDING SSRA 3D-STRUCTURE HOMOLOG BINDING 10 133 2.0E-54 T 17-03-2017 IPR000037 SsrA-binding protein GO:0003723 SHXM_RS12210 fa9bc65deb4b91ded0179d394fcbaeb6 460 Pfam PF00860 Permease family 36 406 4.8E-66 T 17-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 SUPERFAMILY SSF90123 24 319 3.66E-12 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 Gene3D G3DSA:1.20.1560.10 29 322 1.1E-4 T 17-03-2017 SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 Gene3D G3DSA:3.40.50.300 355 606 3.8E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 Pfam PF00005 ABC transporter 372 526 1.4E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 SUPERFAMILY SSF52540 346 599 3.69E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 ProSitePatterns PS00211 ABC transporters family signature. 497 511 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS15410 9679c0da441bdedca921b6fe4cf18046 609 SMART SM00382 381 575 2.5E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 Gene3D G3DSA:3.40.640.10 96 377 9.7E-97 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 82 424 1.7E-69 T 17-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 86 105 8.5E-9 T 17-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 126 145 8.5E-9 T 17-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 406 425 8.5E-9 T 17-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 PRINTS PR00800 Aromatic-L-amino-acid decarboxylase signature 363 378 8.5E-9 T 17-03-2017 IPR010977 Aromatic-L-amino-acid decarboxylase GO:0006520|GO:0016831 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 SUPERFAMILY SSF53383 38 494 9.07E-123 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 Gene3D G3DSA:3.90.1150.10 378 494 1.5E-40 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS32275 ad53487af94a2ab8b0bb365889a9cea7 513 Gene3D G3DSA:1.20.1650.10 9 85 6.2E-21 T 17-03-2017 SHXM_RS31230 d94e7ddaef44ab244394a4f3a44e0445 61 ProSitePatterns PS00527 Ribosomal protein S14 signature. 23 45 - T 17-03-2017 IPR018271 Ribosomal protein S14, conserved site GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31230 d94e7ddaef44ab244394a4f3a44e0445 61 Hamap MF_01364_B 30S ribosomal protein S14 type Z [rpsZ]. 1 61 25.525 T 17-03-2017 IPR023053 Ribosomal protein S14, type Z SHXM_RS31230 d94e7ddaef44ab244394a4f3a44e0445 61 Pfam PF00253 Ribosomal protein S14p/S29e 9 60 1.4E-24 T 17-03-2017 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31230 d94e7ddaef44ab244394a4f3a44e0445 61 SUPERFAMILY SSF57716 4 61 1.43E-21 T 17-03-2017 SHXM_RS31230 d94e7ddaef44ab244394a4f3a44e0445 61 Gene3D G3DSA:4.10.830.10 2 61 1.2E-27 T 17-03-2017 SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 PIRSF PIRSF004486 1 315 9.8E-97 T 17-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 SUPERFAMILY SSF53335 219 314 6.48E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 SUPERFAMILY SSF53335 7 117 6.48E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 Pfam PF01795 MraW methylase family 5 313 2.0E-112 T 17-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 Gene3D G3DSA:3.40.50.150 7 114 2.5E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 Gene3D G3DSA:3.40.50.150 222 316 2.5E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 Gene3D G3DSA:1.10.150.170 116 221 3.4E-35 T 17-03-2017 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 TIGRFAM TIGR00006 TIGR00006: 16S rRNA (cytosine(1402)-N(4))-methyltransferase 3 313 9.0E-94 T 17-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 Hamap MF_01007 Ribosomal RNA small subunit methyltransferase H [rsmH]. 7 314 36.58 T 17-03-2017 IPR002903 Ribosomal RNA small subunit methyltransferase H GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS18605 8e0b59caad7ebec6b870c990bee373c0 320 SUPERFAMILY SSF81799 118 219 4.58E-32 T 17-03-2017 IPR023397 S-adenosyl-L-methionine-dependent methyltransferase, MraW, recognition domain GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 SUPERFAMILY SSF52518 8 190 1.42E-40 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 SUPERFAMILY SSF52518 366 531 5.72E-43 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 SUPERFAMILY SSF52467 163 356 9.63E-39 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 Gene3D G3DSA:3.40.50.970 366 528 4.7E-44 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 9 180 4.0E-44 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 ProSitePatterns PS00187 Thiamine pyrophosphate enzymes signature. 421 440 - T 17-03-2017 IPR000399 TPP-binding enzyme, conserved site GO:0000287|GO:0030976 SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 390 528 5.0E-32 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 200 330 2.2E-33 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 Gene3D G3DSA:3.40.50.1220 191 339 3.6E-46 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS36715 34d2a9cf71d3710b0afbf5485104e478 558 Gene3D G3DSA:3.40.50.970 8 183 3.9E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS01065 580146707e2b21a70430a33b48aae906 106 SUPERFAMILY SSF54909 1 96 7.04E-17 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS01065 580146707e2b21a70430a33b48aae906 106 Pfam PF03992 Antibiotic biosynthesis monooxygenase 6 78 6.7E-11 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS01065 580146707e2b21a70430a33b48aae906 106 Gene3D G3DSA:3.30.70.900 3 96 9.7E-19 T 17-03-2017 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 PIRSF PIRSF016578 1 383 1.5E-12 T 17-03-2017 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 SUPERFAMILY SSF56645 4 247 6.15E-79 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 Gene3D G3DSA:2.40.110.10 123 223 1.2E-36 T 17-03-2017 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 119 1.2E-34 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 Gene3D G3DSA:1.20.140.10 224 383 1.6E-55 T 17-03-2017 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 238 383 1.5E-39 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 Gene3D G3DSA:1.10.540.10 6 119 4.4E-37 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 123 223 1.1E-24 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 342 361 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS22590 590848d21c01792864c42ea098258a3c 385 SUPERFAMILY SSF47203 233 383 8.86E-46 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS38305 11dd2576d5537954fd8f12b3a96f8812 336 TIGRFAM TIGR04222 near_uncomplex: TIGR04222 domain 8 244 6.2E-34 T 17-03-2017 IPR026467 Ser/Gly rich, Cys interspersed, C-terminal domain SHXM_RS21800 603244898b84603dced563e95e98063c 213 Pfam PF00081 Iron/manganese superoxide dismutases, alpha-hairpin domain 4 83 1.3E-28 T 17-03-2017 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 PIRSF PIRSF000349 1 208 2.6E-70 T 17-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 PRINTS PR01703 Manganese superoxide dismutase signature 7 18 3.4E-18 T 17-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 PRINTS PR01703 Manganese superoxide dismutase signature 125 133 3.4E-18 T 17-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 PRINTS PR01703 Manganese superoxide dismutase signature 163 175 3.4E-18 T 17-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 PRINTS PR01703 Manganese superoxide dismutase signature 28 41 3.4E-18 T 17-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 PRINTS PR01703 Manganese superoxide dismutase signature 67 80 3.4E-18 T 17-03-2017 IPR001189 Manganese/iron superoxide dismutase GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 Pfam PF02777 Iron/manganese superoxide dismutases, C-terminal domain 98 198 2.1E-32 T 17-03-2017 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 Gene3D G3DSA:1.10.287.990 22 84 3.3E-21 T 17-03-2017 SHXM_RS21800 603244898b84603dced563e95e98063c 213 SUPERFAMILY SSF46609 3 89 1.83E-29 T 17-03-2017 IPR019831 Manganese/iron superoxide dismutase, N-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 SUPERFAMILY SSF54719 98 206 9.95E-38 T 17-03-2017 IPR019832 Manganese/iron superoxide dismutase, C-terminal GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS21800 603244898b84603dced563e95e98063c 213 ProSitePatterns PS00088 Manganese and iron superoxide dismutases signature. 165 172 - T 17-03-2017 IPR019833 Manganese/iron superoxide dismutase, binding site GO:0004784|GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Gene3D G3DSA:1.10.1200.10 517 578 9.7E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 SUPERFAMILY SSF47336 507 574 1.11E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 ProSitePatterns PS00455 Putative AMP-binding domain signature. 151 162 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Gene3D G3DSA:3.30.300.30 401 516 1.8E-22 T 17-03-2017 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Gene3D G3DSA:3.40.50.980 161 301 2.3E-23 T 17-03-2017 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Gene3D G3DSA:3.40.50.980 16 160 9.4E-36 T 17-03-2017 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Gene3D G3DSA:2.30.38.10 313 393 1.5E-28 T 17-03-2017 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Pfam PF13193 AMP-binding enzyme C-terminal domain 412 485 1.2E-6 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 SUPERFAMILY SSF56801 12 524 1.22E-122 T 17-03-2017 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 SMART SM00823 Phosphopantetheine attachment site 512 581 4.9E-4 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 ProSitePatterns PS00012 Phosphopantetheine attachment site. 536 551 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Pfam PF00550 Phosphopantetheine attachment site 513 575 6.5E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04765 eee6be8d57fcb2ae8c0e6d8deb28df48 585 Pfam PF00501 AMP-binding enzyme 21 398 2.7E-72 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 SUPERFAMILY SSF51735 3 240 1.97E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 128 136 4.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 4.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 4.1E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 Gene3D G3DSA:3.40.50.720 3 241 1.0E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3 179 0.006 T 17-03-2017 SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 Pfam PF00106 short chain dehydrogenase 4 186 1.8E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 122 138 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS20070 15b2316cef8cbc3a01d23b7600f92fd9 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 243 275 2.5E-14 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 TIGRFAM TIGR03535 DapD_actino: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase 11 328 6.8E-154 T 17-03-2017 IPR019875 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, actinobacteria KEGG: 00300+2.3.1.117 SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 Pfam PF14789 Tetrahydrodipicolinate N-succinyltransferase middle 121 161 4.5E-16 T 17-03-2017 IPR032784 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain KEGG: 00300+2.3.1.117 SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 Gene3D G3DSA:3.30.60.70 121 161 3.3E-13 T 17-03-2017 IPR032784 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase, middle domain KEGG: 00300+2.3.1.117 SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 Hamap MF_02122 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [dapD]. 9 326 44.238 T 17-03-2017 IPR026586 Type 2 tetrahydrodipicolinate N-succinyltransferase family GO:0008666 KEGG: 00300+2.3.1.117 SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 Gene3D G3DSA:2.160.10.10 162 311 1.8E-34 T 17-03-2017 SHXM_RS17785 5e2fa9db83f952c082b076e535019c05 329 SUPERFAMILY SSF51161 81 309 1.52E-39 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 SMART SM00895 174 298 2.2E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 SUPERFAMILY SSF46785 79 149 2.59E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 Pfam PF00392 Bacterial regulatory proteins, gntR family 86 145 2.5E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 Pfam PF07729 FCD domain 174 296 8.2E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 SUPERFAMILY SSF48008 171 297 1.02E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 Gene3D G3DSA:1.10.10.10 78 147 1.0E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 SMART SM00345 87 145 1.1E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS37460 c2223e06c458e8a7306655f8a36311c0 315 Gene3D G3DSA:1.20.120.530 171 297 1.4E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS02185 01896c428e3f30b1fc472e1e14f75be4 85 Gene3D G3DSA:1.10.1200.10 3 80 3.9E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02185 01896c428e3f30b1fc472e1e14f75be4 85 Pfam PF00550 Phosphopantetheine attachment site 10 75 3.1E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02185 01896c428e3f30b1fc472e1e14f75be4 85 SUPERFAMILY SSF47336 3 80 1.31E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 Pfam PF00512 His Kinase A (phospho-acceptor) domain 253 313 1.1E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 SUPERFAMILY SSF55874 304 467 1.44E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 Pfam PF00672 HAMP domain 182 247 1.6E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 PRINTS PR00344 Bacterial sensor protein C-terminal signature 452 465 1.4E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 PRINTS PR00344 Bacterial sensor protein C-terminal signature 395 409 1.4E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 PRINTS PR00344 Bacterial sensor protein C-terminal signature 428 446 1.4E-8 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 359 466 1.2E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 SMART SM00304 198 251 2.3E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 SUPERFAMILY SSF47384 235 313 3.53E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 SMART SM00388 252 315 1.4E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 SUPERFAMILY SSF158472 199 249 2.75E-7 T 17-03-2017 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 Gene3D G3DSA:1.10.287.130 242 310 2.3E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 SMART SM00387 358 468 3.0E-27 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37290 ba45870dc4ed78731a89eaafa05cd0a4 481 Gene3D G3DSA:3.30.565.10 318 467 2.1E-30 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS46450 d20c91e11bdb4b63f48625ec6759ddc7 268 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 82 255 7.6E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46450 d20c91e11bdb4b63f48625ec6759ddc7 268 Gene3D G3DSA:1.10.3720.10 6 256 1.7E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46450 d20c91e11bdb4b63f48625ec6759ddc7 268 SUPERFAMILY SSF161098 4 255 4.71E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27045 0d753eb8619fbe54dca84116d9e5e726 156 SUPERFAMILY SSF89095 4 153 3.92E-34 T 17-03-2017 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-related GO:0016884 SHXM_RS27045 0d753eb8619fbe54dca84116d9e5e726 156 Pfam PF09424 Yqey-like protein 6 153 2.9E-44 T 17-03-2017 IPR019004 Uncharacterised domain YOR215C, mitochondrial SHXM_RS27045 0d753eb8619fbe54dca84116d9e5e726 156 Gene3D G3DSA:1.10.1510.10 4 94 5.2E-26 T 17-03-2017 SHXM_RS27045 0d753eb8619fbe54dca84116d9e5e726 156 Gene3D G3DSA:1.10.10.410 95 154 3.7E-19 T 17-03-2017 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal SHXM_RS02930 23311c4eb924f2ed76ea2154316ad682 247 SUPERFAMILY SSF46955 1 104 6.59E-26 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS02930 23311c4eb924f2ed76ea2154316ad682 247 SMART SM00422 1 70 4.5E-24 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS02930 23311c4eb924f2ed76ea2154316ad682 247 Gene3D G3DSA:1.10.1660.10 1 111 2.2E-29 T 17-03-2017 SHXM_RS02930 23311c4eb924f2ed76ea2154316ad682 247 Pfam PF00376 MerR family regulatory protein 2 39 4.0E-17 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS02435 5754d918594ad0c7ab27cdd0fb52cfc8 412 Pfam PF07728 AAA domain (dynein-related subfamily) 57 186 1.9E-22 T 17-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 SHXM_RS02435 5754d918594ad0c7ab27cdd0fb52cfc8 412 Gene3D G3DSA:3.40.50.300 23 192 3.3E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02435 5754d918594ad0c7ab27cdd0fb52cfc8 412 SUPERFAMILY SSF52540 29 275 1.18E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32310 ea0e7a24d4919bdb8bd3ab022c97d25e 209 Gene3D G3DSA:1.10.357.10 7 190 3.7E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32310 ea0e7a24d4919bdb8bd3ab022c97d25e 209 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 57 3.7E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32310 ea0e7a24d4919bdb8bd3ab022c97d25e 209 SUPERFAMILY SSF46689 7 80 2.09E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 Pfam PF07729 FCD domain 83 198 5.2E-12 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 Pfam PF00392 Bacterial regulatory proteins, gntR family 9 69 2.5E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 Gene3D G3DSA:1.20.120.530 73 212 5.8E-19 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 SUPERFAMILY SSF46785 4 74 3.13E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 SUPERFAMILY SSF48008 76 210 2.33E-14 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 SMART SM00895 80 202 0.002 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 Gene3D G3DSA:1.10.10.10 3 69 2.8E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 SMART SM00345 12 70 2.3E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 30 44 6.3E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13950 67b08b385abfb55a3ea046cbc90805e1 213 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 60 6.3E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34320 3ed3589e2aa232bbc54d9a25ab85244e 468 SUPERFAMILY SSF56112 195 313 7.14E-22 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS34320 3ed3589e2aa232bbc54d9a25ab85244e 468 SUPERFAMILY SSF56112 95 158 7.14E-22 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS34320 3ed3589e2aa232bbc54d9a25ab85244e 468 Pfam PF03109 ABC1 family 113 227 1.2E-30 T 17-03-2017 IPR004147 UbiB domain SHXM_RS14755 374e1141817bbbb4d95003fbc06364df 218 Hamap MF_00664 Phosphatidylserine decarboxylase proenzyme [psd]. 17 218 32.572 T 17-03-2017 IPR033175 Phosphatidylserine decarboxylase, archaeal-type KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669 SHXM_RS14755 374e1141817bbbb4d95003fbc06364df 218 Pfam PF02666 Phosphatidylserine decarboxylase 59 212 5.6E-30 T 17-03-2017 IPR003817 Phosphatidylserine decarboxylase-related GO:0004609|GO:0008654 KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669|Reactome: R-HSA-1483213 SHXM_RS14755 374e1141817bbbb4d95003fbc06364df 218 TIGRFAM TIGR00164 PS_decarb_rel: phosphatidylserine decarboxylase homolog 46 215 6.0E-53 T 17-03-2017 IPR033175 Phosphatidylserine decarboxylase, archaeal-type KEGG: 00564+4.1.1.65|MetaCyc: PWY-5669 SHXM_RS14740 e4884388c6045e7914144311caeb0480 326 Gene3D G3DSA:3.20.20.60 12 258 1.7E-78 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS14740 e4884388c6045e7914144311caeb0480 326 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 17 247 8.3E-47 T 17-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 SHXM_RS14740 e4884388c6045e7914144311caeb0480 326 PIRSF PIRSF015582 2 324 6.4E-89 T 17-03-2017 IPR011206 Citrate lyase beta subunit-like SHXM_RS14740 e4884388c6045e7914144311caeb0480 326 SUPERFAMILY SSF51621 13 258 1.38E-65 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS18405 833da348ff64a88c0f6e3b40bf4aa40b 221 SUPERFAMILY SSF52317 13 219 1.42E-53 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS18405 833da348ff64a88c0f6e3b40bf4aa40b 221 Pfam PF00117 Glutamine amidotransferase class-I 17 216 7.4E-17 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS18405 833da348ff64a88c0f6e3b40bf4aa40b 221 TIGRFAM TIGR01855 IMP_synth_hisH: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit 15 219 7.8E-62 T 17-03-2017 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 SHXM_RS18405 833da348ff64a88c0f6e3b40bf4aa40b 221 Hamap MF_00278 Imidazole glycerol phosphate synthase subunit HisH [hisH]. 14 220 30.943 T 17-03-2017 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 SHXM_RS18405 833da348ff64a88c0f6e3b40bf4aa40b 221 PIRSF PIRSF000495 13 221 1.1E-64 T 17-03-2017 IPR010139 Imidazole glycerol phosphate synthase, subunit H GO:0000105|GO:0005737|GO:0016763 SHXM_RS18405 833da348ff64a88c0f6e3b40bf4aa40b 221 Gene3D G3DSA:3.40.50.880 12 219 4.3E-76 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS08370 14b45d146e53282fcfe459aaed5d6d40 270 SUPERFAMILY SSF53335 19 254 5.23E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08370 14b45d146e53282fcfe459aaed5d6d40 270 PIRSF PIRSF017393 1 270 7.4E-102 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS08370 14b45d146e53282fcfe459aaed5d6d40 270 Gene3D G3DSA:3.40.50.150 7 270 2.4E-105 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08370 14b45d146e53282fcfe459aaed5d6d40 270 Pfam PF04672 S-adenosyl methyltransferase 11 270 3.1E-102 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 SUPERFAMILY SSF46785 7 76 1.86E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 SUPERFAMILY SSF55781 71 251 4.05E-36 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 Gene3D G3DSA:1.10.10.10 7 72 1.1E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 Gene3D G3DSA:3.30.450.40 74 251 1.8E-40 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 Pfam PF09339 IclR helix-turn-helix domain 7 57 3.1E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 Pfam PF01614 Bacterial transcriptional regulator 128 249 2.5E-23 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS15570 fb7cbd65de4a498a54c70a2eeef5f7a0 265 SMART SM00346 4 94 8.2E-9 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS36220 4a877c195f175475cb009c4034982a8b 308 SUPERFAMILY SSF51730 35 302 7.45E-68 T 17-03-2017 IPR029041 FAD-linked oxidoreductase-like SHXM_RS36220 4a877c195f175475cb009c4034982a8b 308 PIRSF PIRSF000196 1 308 1.9E-111 T 17-03-2017 IPR008219 Proline dehydrogenase GO:0004657|GO:0010133 KEGG: 00330+1.5.5.2|MetaCyc: PWY-5737|MetaCyc: PWY-6922 SHXM_RS36220 4a877c195f175475cb009c4034982a8b 308 Pfam PF01619 Proline dehydrogenase 45 299 2.2E-30 T 17-03-2017 IPR002872 Proline dehydrogenase domain KEGG: 00330+1.5.5.2|MetaCyc: PWY-5737|MetaCyc: PWY-6922 SHXM_RS36220 4a877c195f175475cb009c4034982a8b 308 Gene3D G3DSA:3.20.20.220 34 302 3.5E-69 T 17-03-2017 IPR029041 FAD-linked oxidoreductase-like SHXM_RS47640 7292e758e9acc1b9e32ae143b8ce1ec3 396 Gene3D G3DSA:1.50.10.110 25 364 2.5E-30 T 17-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SHXM_RS47640 7292e758e9acc1b9e32ae143b8ce1ec3 396 Pfam PF05426 Alginate lyase 95 326 1.1E-9 T 17-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SHXM_RS47640 7292e758e9acc1b9e32ae143b8ce1ec3 396 SUPERFAMILY SSF48230 278 340 4.3E-40 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS47640 7292e758e9acc1b9e32ae143b8ce1ec3 396 SUPERFAMILY SSF48230 38 248 4.3E-40 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS45535 b27dc794503b0926f1fe75714bbc9332 238 Pfam PF01925 Sulfite exporter TauE/SafE 9 230 3.3E-18 T 17-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 SHXM_RS35325 d0cc966fe5cda2ca7022ac8ad28ed504 223 Gene3D G3DSA:3.40.1350.10 120 159 3.8E-4 T 17-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 SHXM_RS35325 d0cc966fe5cda2ca7022ac8ad28ed504 223 Pfam PF01939 Protein of unknown function DUF91 4 223 2.4E-81 T 17-03-2017 IPR002793 Endonuclease NucS SHXM_RS35325 d0cc966fe5cda2ca7022ac8ad28ed504 223 Hamap MF_00722 Endonuclease NucS [nucS]. 4 215 31.092 T 17-03-2017 IPR002793 Endonuclease NucS SHXM_RS41370 26ffab77c95adca0a9a2183afe913ae7 354 SUPERFAMILY SSF53686 37 348 1.83E-86 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS41370 26ffab77c95adca0a9a2183afe913ae7 354 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 48 340 1.9E-70 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS41370 26ffab77c95adca0a9a2183afe913ae7 354 Gene3D G3DSA:3.40.50.1100 102 351 3.6E-57 T 17-03-2017 SHXM_RS39890 e9fd7fe7d4721d45eb3504ae519cc472 114 Gene3D G3DSA:3.40.50.720 19 110 1.7E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39890 e9fd7fe7d4721d45eb3504ae519cc472 114 SUPERFAMILY SSF51735 19 111 2.16E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39890 e9fd7fe7d4721d45eb3504ae519cc472 114 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 21 112 3.8E-18 T 17-03-2017 SHXM_RS21340 0a542e99e2c67139a569982ca1b9254d 331 Pfam PF06144 DNA polymerase III, delta subunit 16 179 2.1E-11 T 17-03-2017 IPR010372 DNA polymerase III delta, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0009360 SHXM_RS21340 0a542e99e2c67139a569982ca1b9254d 331 SUPERFAMILY SSF48019 203 320 4.25E-15 T 17-03-2017 IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal GO:0003677|GO:0006260 Reactome: R-HSA-110312|Reactome: R-HSA-110314|Reactome: R-HSA-110320|Reactome: R-HSA-174411|Reactome: R-HSA-5651801|Reactome: R-HSA-5655862|Reactome: R-HSA-5656121|Reactome: R-HSA-5656169|Reactome: R-HSA-5685942|Reactome: R-HSA-5696397|Reactome: R-HSA-5696400|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-69091 SHXM_RS21340 0a542e99e2c67139a569982ca1b9254d 331 Gene3D G3DSA:3.40.50.300 9 105 9.3E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21340 0a542e99e2c67139a569982ca1b9254d 331 TIGRFAM TIGR01128 holA: DNA polymerase III, delta subunit 11 320 1.4E-32 T 17-03-2017 IPR005790 DNA polymerase III, delta subunit GO:0003677|GO:0006260 SHXM_RS21340 0a542e99e2c67139a569982ca1b9254d 331 SUPERFAMILY SSF52540 9 186 2.92E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21340 0a542e99e2c67139a569982ca1b9254d 331 Gene3D G3DSA:1.10.8.60 137 220 3.4E-7 T 17-03-2017 SHXM_RS46695 886f7533ef29a72fb064661d0dda7483 340 Gene3D G3DSA:3.40.50.2300 174 308 1.0E-16 T 17-03-2017 SHXM_RS46695 886f7533ef29a72fb064661d0dda7483 340 Pfam PF13407 Periplasmic binding protein domain 58 304 6.4E-40 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS46695 886f7533ef29a72fb064661d0dda7483 340 SUPERFAMILY SSF53822 55 330 8.41E-51 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS46695 886f7533ef29a72fb064661d0dda7483 340 Gene3D G3DSA:3.40.50.2300 51 173 7.2E-30 T 17-03-2017 SHXM_RS02020 5a72625b5152b66cc284235f458cd2dc 123 Gene3D G3DSA:1.10.10.10 9 121 1.0E-38 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02020 5a72625b5152b66cc284235f458cd2dc 123 Pfam PF01638 HxlR-like helix-turn-helix 26 113 5.9E-29 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS02020 5a72625b5152b66cc284235f458cd2dc 123 SUPERFAMILY SSF46785 20 120 3.5E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04955 11f8f5fc0fbc26f481a6d03146fffc15 298 Pfam PF00753 Metallo-beta-lactamase superfamily 58 273 8.2E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS04955 11f8f5fc0fbc26f481a6d03146fffc15 298 SUPERFAMILY SSF56281 59 290 7.08E-37 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS04955 11f8f5fc0fbc26f481a6d03146fffc15 298 SMART SM00849 58 273 1.9E-21 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS04955 11f8f5fc0fbc26f481a6d03146fffc15 298 Gene3D G3DSA:3.60.15.10 2 292 2.4E-48 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS42550 8731a290318aac4e3e4d8a4dd529f8b7 263 SUPERFAMILY SSF53850 6 254 2.35E-41 T 17-03-2017 SHXM_RS42550 8731a290318aac4e3e4d8a4dd529f8b7 263 TIGRFAM TIGR01098 3A0109s03R: phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein 2 210 2.1E-55 T 17-03-2017 IPR005770 Phosphate/phosphite/phosphonate ABC transporter, periplasmic binding protein GO:0043190|GO:0055085 SHXM_RS42550 8731a290318aac4e3e4d8a4dd529f8b7 263 Pfam PF12974 ABC transporter, phosphonate, periplasmic substrate-binding protein 3 244 2.7E-58 T 17-03-2017 SHXM_RS42550 8731a290318aac4e3e4d8a4dd529f8b7 263 Gene3D G3DSA:3.40.190.10 90 194 2.9E-12 T 17-03-2017 SHXM_RS43670 426e06c190b233585c13cb7a918bf45e 409 Pfam PF13439 Glycosyltransferase Family 4 21 185 3.5E-15 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS43670 426e06c190b233585c13cb7a918bf45e 409 Pfam PF00534 Glycosyl transferases group 1 208 356 3.6E-22 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS43670 426e06c190b233585c13cb7a918bf45e 409 SUPERFAMILY SSF53756 8 371 6.98E-59 T 17-03-2017 SHXM_RS43670 426e06c190b233585c13cb7a918bf45e 409 Gene3D G3DSA:3.40.50.2000 175 356 2.3E-25 T 17-03-2017 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 Gene3D G3DSA:3.40.190.10 180 267 1.1E-12 T 17-03-2017 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 Pfam PF03466 LysR substrate binding domain 101 293 4.0E-24 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 SUPERFAMILY SSF46785 11 93 2.34E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 Gene3D G3DSA:1.10.10.10 11 95 1.1E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 28 39 4.8E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 49 60 4.8E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 49 4.8E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 SUPERFAMILY SSF53850 100 298 2.29E-24 T 17-03-2017 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 Gene3D G3DSA:3.40.190.10 99 179 3.3E-14 T 17-03-2017 SHXM_RS44320 305ec8c6b4330dedde3305986bbc0c7a 308 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 13 72 1.8E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS42660 47befabf317699792db0489cfcda3e7f 265 ProSitePatterns PS00211 ABC transporters family signature. 144 158 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS42660 47befabf317699792db0489cfcda3e7f 265 SUPERFAMILY SSF52540 30 227 2.88E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42660 47befabf317699792db0489cfcda3e7f 265 Pfam PF00005 ABC transporter 46 171 5.1E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS42660 47befabf317699792db0489cfcda3e7f 265 SMART SM00382 54 221 5.6E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS42660 47befabf317699792db0489cfcda3e7f 265 Gene3D G3DSA:3.40.50.300 28 228 2.6E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41335 51abc99ca6f68507613650bb070d453d 361 Gene3D G3DSA:3.40.50.720 144 324 1.7E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41335 51abc99ca6f68507613650bb070d453d 361 SUPERFAMILY SSF51735 144 325 1.43E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41335 51abc99ca6f68507613650bb070d453d 361 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 153 324 7.7E-47 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS41335 51abc99ca6f68507613650bb070d453d 361 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 263 279 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS38345 8139aa5790000f9310b480f0989fcf50 252 Pfam PF13489 Methyltransferase domain 81 188 6.6E-8 T 17-03-2017 SHXM_RS38345 8139aa5790000f9310b480f0989fcf50 252 SUPERFAMILY SSF53335 81 234 9.56E-16 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS38345 8139aa5790000f9310b480f0989fcf50 252 Gene3D G3DSA:3.40.50.150 83 192 1.8E-12 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS07120 e43d02264fa4b9b9cd7a9f21eed93ea3 153 Gene3D G3DSA:3.40.50.620 18 153 2.2E-24 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS07120 e43d02264fa4b9b9cd7a9f21eed93ea3 153 SUPERFAMILY SSF52402 19 153 3.1E-24 T 17-03-2017 SHXM_RS07120 e43d02264fa4b9b9cd7a9f21eed93ea3 153 PRINTS PR01438 Universal stress protein signature 131 153 3.9E-5 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07120 e43d02264fa4b9b9cd7a9f21eed93ea3 153 PRINTS PR01438 Universal stress protein signature 16 34 3.9E-5 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07120 e43d02264fa4b9b9cd7a9f21eed93ea3 153 Pfam PF00582 Universal stress protein family 17 153 2.2E-21 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 295 311 2.9E-30 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 2.9E-30 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 280 295 2.9E-30 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 153 168 2.9E-30 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 312 330 2.9E-30 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 Gene3D G3DSA:3.30.9.10 155 301 1.7E-64 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 Pfam PF01494 FAD binding domain 3 345 9.1E-79 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 SUPERFAMILY SSF51905 276 391 1.56E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 SUPERFAMILY SSF51905 1 174 1.56E-56 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 SUPERFAMILY SSF54373 177 277 8.24E-37 T 17-03-2017 SHXM_RS38275 9c947b802c2da4ff4d658b9cf6c9028a 393 Gene3D G3DSA:3.50.50.60 3 154 9.3E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS00650 60d4c854952e37555a1cc216f821dd40 330 Pfam PF00248 Aldo/keto reductase family 17 310 6.4E-66 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS00650 60d4c854952e37555a1cc216f821dd40 330 PRINTS PR00069 Aldo-keto reductase signature 140 157 4.1E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS00650 60d4c854952e37555a1cc216f821dd40 330 PRINTS PR00069 Aldo-keto reductase signature 240 264 4.1E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS00650 60d4c854952e37555a1cc216f821dd40 330 PRINTS PR00069 Aldo-keto reductase signature 109 127 4.1E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS00650 60d4c854952e37555a1cc216f821dd40 330 Gene3D G3DSA:3.20.20.100 2 319 1.3E-103 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS00650 60d4c854952e37555a1cc216f821dd40 330 SUPERFAMILY SSF51430 4 311 1.28E-92 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS33940 80bab7a537286d09f67a8dfdb17f585c 234 Gene3D G3DSA:3.40.630.30 114 230 1.2E-10 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33940 80bab7a537286d09f67a8dfdb17f585c 234 SUPERFAMILY SSF55729 33 229 1.36E-13 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33940 80bab7a537286d09f67a8dfdb17f585c 234 Pfam PF00583 Acetyltransferase (GNAT) family 150 223 2.1E-4 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS19905 0579bd490c5087ab6650b526ec943c87 354 PRINTS PR00069 Aldo-keto reductase signature 257 281 4.8E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS19905 0579bd490c5087ab6650b526ec943c87 354 PRINTS PR00069 Aldo-keto reductase signature 113 131 4.8E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS19905 0579bd490c5087ab6650b526ec943c87 354 PRINTS PR00069 Aldo-keto reductase signature 48 72 4.8E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS19905 0579bd490c5087ab6650b526ec943c87 354 Pfam PF00248 Aldo/keto reductase family 20 324 5.4E-75 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS19905 0579bd490c5087ab6650b526ec943c87 354 SUPERFAMILY SSF51430 8 323 6.94E-97 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS19905 0579bd490c5087ab6650b526ec943c87 354 Gene3D G3DSA:3.20.20.100 14 325 3.8E-97 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS10010 ef241b407990b97482a812c4de2664d3 310 SUPERFAMILY SSF53955 48 176 1.13E-30 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS10010 ef241b407990b97482a812c4de2664d3 310 Gene3D G3DSA:3.90.1720.10 179 304 4.1E-36 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS10010 ef241b407990b97482a812c4de2664d3 310 Pfam PF01464 Transglycosylase SLT domain 64 170 3.0E-9 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS10010 ef241b407990b97482a812c4de2664d3 310 SUPERFAMILY SSF54001 176 292 6.38E-34 T 17-03-2017 SHXM_RS10010 ef241b407990b97482a812c4de2664d3 310 Pfam PF00877 NlpC/P60 family 197 289 4.4E-20 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS10010 ef241b407990b97482a812c4de2664d3 310 Gene3D G3DSA:1.10.530.10 52 174 9.5E-17 T 17-03-2017 SHXM_RS49045 f2261aea734547108aa6a142c9fa2966 242 SUPERFAMILY SSF51735 19 224 3.57E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49045 f2261aea734547108aa6a142c9fa2966 242 TIGRFAM TIGR01915 npdG: NADPH-dependent F420 reductase 20 226 1.7E-54 T 17-03-2017 IPR010185 NADPH-dependent F420 reductase GO:0006740|GO:0016651|GO:0050661|GO:0055114|GO:0070967 SHXM_RS49045 f2261aea734547108aa6a142c9fa2966 242 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 20 111 9.9E-17 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS49045 f2261aea734547108aa6a142c9fa2966 242 Gene3D G3DSA:3.40.50.720 19 222 1.1E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 SUPERFAMILY SSF49785 196 356 9.22E-20 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 SUPERFAMILY SSF49785 61 187 8.51E-29 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 Pfam PF00722 Glycosyl hydrolases family 16 413 630 2.1E-33 T 17-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 Gene3D G3DSA:2.60.120.200 371 635 7.6E-65 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 Pfam PF00754 F5/8 type C domain 217 335 3.9E-23 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 Pfam PF00754 F5/8 type C domain 66 180 3.0E-25 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 Gene3D G3DSA:2.60.120.260 60 188 1.3E-26 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 SUPERFAMILY SSF49899 372 635 1.17E-63 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS06890 00a13ffcc8b8ccbf677227daf8c1c278 636 Gene3D G3DSA:2.60.120.260 198 356 5.4E-22 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 SUPERFAMILY SSF46785 14 79 5.2E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 SMART SM00345 17 75 8.4E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 Pfam PF07729 FCD domain 86 208 4.3E-26 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 Gene3D G3DSA:1.10.10.10 3 76 2.3E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 65 1.7E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 35 49 1.7E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 SUPERFAMILY SSF48008 81 216 3.92E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 Gene3D G3DSA:1.20.120.530 79 219 1.2E-30 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 SMART SM00895 85 209 6.2E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS04645 f6d923e97b11a306fe2334018db28ad2 222 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 75 1.7E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 PIRSF PIRSF006493 1 301 4.3E-75 T 17-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 Hamap MF_01875 Non-homologous end joining protein Ku [ku]. 1 253 29.668 T 17-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 TIGRFAM TIGR02772 Ku_bact: Ku protein 1 255 1.3E-84 T 17-03-2017 IPR009187 Non-homologous end joining protein Ku, prokaryotic type SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 SMART SM00559 52 181 2.3E-33 T 17-03-2017 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: R-HSA-164843|Reactome: R-HSA-1834949|Reactome: R-HSA-3270619|Reactome: R-HSA-5693571 SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 SUPERFAMILY SSF100939 1 256 7.26E-44 T 17-03-2017 IPR016194 SPOC-like, C-terminal domain SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 Gene3D G3DSA:2.40.290.10 3 147 1.1E-8 T 17-03-2017 IPR016194 SPOC-like, C-terminal domain SHXM_RS31995 482a0582b3ec50b81c1f3d3445587bb3 366 Pfam PF02735 Ku70/Ku80 beta-barrel domain 11 188 2.5E-31 T 17-03-2017 IPR006164 Ku70/Ku80 beta-barrel domain GO:0003677|GO:0006303 Reactome: R-HSA-164843|Reactome: R-HSA-1834949|Reactome: R-HSA-3270619|Reactome: R-HSA-5693571 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 SMART SM00387 360 467 3.2E-24 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 SUPERFAMILY SSF158472 200 249 1.57E-6 T 17-03-2017 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 Gene3D G3DSA:1.10.287.130 243 315 4.2E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 362 461 4.0E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 PRINTS PR00344 Bacterial sensor protein C-terminal signature 427 445 6.3E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 PRINTS PR00344 Bacterial sensor protein C-terminal signature 412 422 6.3E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 PRINTS PR00344 Bacterial sensor protein C-terminal signature 394 408 6.3E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 SMART SM00304 199 252 1.1E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 Pfam PF00672 HAMP domain 181 248 1.3E-14 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 Gene3D G3DSA:3.30.565.10 326 462 5.4E-28 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 SUPERFAMILY SSF47384 236 316 2.35E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 Pfam PF00512 His Kinase A (phospho-acceptor) domain 254 315 1.9E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 SUPERFAMILY SSF55874 321 462 2.88E-29 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07440 3c6d4ff747839b32c4fa7178f348bf17 470 SMART SM00388 253 320 4.0E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS29930 6566bffa49c8cb5a2c0a66b11e998e49 134 Pfam PF02583 Metal-sensitive transcriptional repressor 41 129 3.9E-29 T 17-03-2017 IPR003735 Metal-sensitive transcriptional repressor GO:0003677|GO:0006355|GO:0046872 SHXM_RS31840 77f6e94795875edb00f9bdd517620679 315 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 39 288 9.4E-72 T 17-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted SHXM_RS31840 77f6e94795875edb00f9bdd517620679 315 SUPERFAMILY SSF51679 21 314 1.7E-68 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS31840 77f6e94795875edb00f9bdd517620679 315 Gene3D G3DSA:3.20.20.30 6 314 6.7E-75 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS31840 77f6e94795875edb00f9bdd517620679 315 Pfam PF00296 Luciferase-like monooxygenase 18 244 1.9E-53 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 TIGRFAM TIGR00861 MIP: MIP family channel proteins 23 262 6.6E-64 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 Gene3D G3DSA:1.20.1080.10 16 269 9.3E-77 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 Pfam PF00230 Major intrinsic protein 16 262 2.2E-53 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 ProSitePatterns PS00221 MIP family signature. 83 91 - T 17-03-2017 IPR022357 Major intrinsic protein, conserved site GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 PRINTS PR00783 Major intrinsic protein family signature 196 218 9.0E-49 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 PRINTS PR00783 Major intrinsic protein family signature 19 38 9.0E-49 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 PRINTS PR00783 Major intrinsic protein family signature 65 89 9.0E-49 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 PRINTS PR00783 Major intrinsic protein family signature 102 121 9.0E-49 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 PRINTS PR00783 Major intrinsic protein family signature 163 181 9.0E-49 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 PRINTS PR00783 Major intrinsic protein family signature 245 265 9.0E-49 T 17-03-2017 IPR000425 Major intrinsic protein GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-432047 SHXM_RS07970 4acdf2e65f017b55d8226da36d9aee90 284 SUPERFAMILY SSF81338 18 266 6.93E-65 T 17-03-2017 IPR023271 Aquaporin-like Reactome: R-HSA-432047 SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 Gene3D G3DSA:1.10.1040.10 190 285 1.6E-33 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 188 284 3.7E-32 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 Gene3D G3DSA:3.40.50.720 3 189 4.0E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 SUPERFAMILY SSF51735 4 185 8.63E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 SUPERFAMILY SSF48179 188 285 8.5E-31 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 PIRSF PIRSF000105 2 286 1.2E-80 T 17-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SHXM_RS40950 62d4c47b0f76624080405cf4c7fa8785 286 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7 185 9.9E-59 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Pfam PF00994 Probable molybdopterin binding domain 238 399 5.0E-20 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Gene3D G3DSA:3.40.980.10 219 408 2.6E-41 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 SUPERFAMILY SSF53218 232 406 6.67E-26 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Gene3D G3DSA:2.170.190.11 102 198 2.0E-17 T 17-03-2017 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Pfam PF03453 MoeA N-terminal region (domain I and II) 68 224 7.1E-30 T 17-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Pfam PF03454 MoeA C-terminal region (domain IV) 412 476 1.9E-8 T 17-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 SUPERFAMILY SSF63882 56 233 1.44E-34 T 17-03-2017 IPR005110 MoeA, N-terminal and linker domain GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 SMART SM00852 237 400 1.3E-27 T 17-03-2017 IPR001453 MoaB/Mog domain SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Gene3D G3DSA:3.90.105.10 199 218 2.1E-12 T 17-03-2017 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Gene3D G3DSA:3.90.105.10 82 101 2.1E-12 T 17-03-2017 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 SUPERFAMILY SSF63867 411 476 2.62E-7 T 17-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS28390 f5492d9fd6729b95a47d888700781bbc 477 Gene3D G3DSA:2.40.340.10 411 475 9.8E-7 T 17-03-2017 IPR005111 MoeA, C-terminal, domain IV GO:0032324 MetaCyc: PWY-6823|Reactome: R-HSA-947581 SHXM_RS20620 8733695afda0a7676127f4358730c7ee 346 SUPERFAMILY SSF53800 207 331 3.27E-18 T 17-03-2017 SHXM_RS20620 8733695afda0a7676127f4358730c7ee 346 SUPERFAMILY SSF53800 37 145 7.59E-25 T 17-03-2017 SHXM_RS20620 8733695afda0a7676127f4358730c7ee 346 Pfam PF01903 CbiX 215 325 3.9E-11 T 17-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 SHXM_RS20620 8733695afda0a7676127f4358730c7ee 346 Pfam PF01903 CbiX 43 139 2.1E-19 T 17-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 SHXM_RS20620 8733695afda0a7676127f4358730c7ee 346 Gene3D G3DSA:3.40.50.1400 207 333 2.7E-22 T 17-03-2017 SHXM_RS20620 8733695afda0a7676127f4358730c7ee 346 Gene3D G3DSA:3.40.50.1400 37 147 8.6E-27 T 17-03-2017 SHXM_RS19315 804b3b550319509062079d020c56f6b9 297 Gene3D G3DSA:1.10.260.40 6 70 6.9E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19315 804b3b550319509062079d020c56f6b9 297 Pfam PF13560 Helix-turn-helix domain 13 68 4.5E-11 T 17-03-2017 SHXM_RS19315 804b3b550319509062079d020c56f6b9 297 SMART SM00530 17 72 1.4E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS19315 804b3b550319509062079d020c56f6b9 297 SUPERFAMILY SSF47413 7 71 3.38E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS42475 a6835538e1d56ab08296763f91924d88 503 Pfam PF00171 Aldehyde dehydrogenase family 33 491 1.1E-161 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS42475 a6835538e1d56ab08296763f91924d88 503 Gene3D G3DSA:3.40.605.10 21 281 9.3E-92 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS42475 a6835538e1d56ab08296763f91924d88 503 Gene3D G3DSA:3.40.309.10 282 467 5.4E-66 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS42475 a6835538e1d56ab08296763f91924d88 503 SUPERFAMILY SSF53720 16 492 3.4E-154 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS42475 a6835538e1d56ab08296763f91924d88 503 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 295 306 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS42475 a6835538e1d56ab08296763f91924d88 503 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 268 275 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 SMART SM00382 425 611 2.5E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 Gene3D G3DSA:1.20.1560.10 66 384 2.6E-73 T 17-03-2017 SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 Pfam PF00005 ABC transporter 417 564 2.5E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 SUPERFAMILY SSF52540 389 632 2.98E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 ProSitePatterns PS00211 ABC transporters family signature. 537 551 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 SUPERFAMILY SSF90123 67 384 4.32E-71 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 Gene3D G3DSA:3.40.50.300 398 629 7.7E-74 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30155 3dadfb736de5ad04229ee1c30707361f 681 Pfam PF00664 ABC transporter transmembrane region 80 348 4.9E-41 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 69 1.0E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 Gene3D G3DSA:1.10.10.60 22 67 3.4E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 SUPERFAMILY SSF46689 20 98 5.03E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 1.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 1.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 Gene3D G3DSA:1.10.357.10 68 207 2.7E-34 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS16410 a83af960ccf46bda66bd67b20bdb9597 216 SUPERFAMILY SSF48498 93 206 5.72E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 SUPERFAMILY SSF55785 8 125 5.8E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 SUPERFAMILY SSF81606 215 413 2.62E-13 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 SMART SM00331 199 413 1.9E-40 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 228 412 1.2E-45 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 8 60 6.9E-6 T 17-03-2017 IPR000014 PAS domain SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 Pfam PF08448 PAS fold 14 134 2.3E-10 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 Gene3D G3DSA:3.30.450.20 8 133 7.0E-14 T 17-03-2017 SHXM_RS00100 4ce8475d5becd625b85f18087a736ef9 413 SMART SM00091 6 72 6.5E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS45630 ea610905d2a6c358e07bc2f75505d306 336 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 266 279 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS45630 ea610905d2a6c358e07bc2f75505d306 336 Gene3D G3DSA:3.40.1190.20 18 322 2.7E-66 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS45630 ea610905d2a6c358e07bc2f75505d306 336 Pfam PF00294 pfkB family carbohydrate kinase 19 310 1.3E-44 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS45630 ea610905d2a6c358e07bc2f75505d306 336 SUPERFAMILY SSF53613 18 321 2.18E-58 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS43640 3cda307069beb1ad390a86e4898c4a47 674 Gene3D G3DSA:3.40.80.10 296 450 4.9E-37 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS43640 3cda307069beb1ad390a86e4898c4a47 674 Gene3D G3DSA:1.10.530.10 170 221 4.8E-5 T 17-03-2017 SHXM_RS43640 3cda307069beb1ad390a86e4898c4a47 674 Gene3D G3DSA:1.10.530.10 65 125 4.8E-5 T 17-03-2017 SHXM_RS43640 3cda307069beb1ad390a86e4898c4a47 674 SUPERFAMILY SSF55846 286 451 5.04E-38 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS43640 3cda307069beb1ad390a86e4898c4a47 674 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 310 439 1.4E-18 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS43640 3cda307069beb1ad390a86e4898c4a47 674 SMART SM00644 301 438 1.4E-42 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS46725 dbb8c87d982faa2ab2e8a64a6ab6a48e 353 Gene3D G3DSA:1.10.3470.10 29 351 3.2E-87 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS46725 dbb8c87d982faa2ab2e8a64a6ab6a48e 353 SUPERFAMILY SSF81345 20 349 1.31E-68 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS46725 dbb8c87d982faa2ab2e8a64a6ab6a48e 353 Pfam PF01032 FecCD transport family 39 349 3.3E-82 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS22470 823649528637cee1978b09ef0dd07a95 373 Pfam PF00892 EamA-like transporter family 141 280 8.4E-15 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS22470 823649528637cee1978b09ef0dd07a95 373 Pfam PF00892 EamA-like transporter family 6 130 8.3E-16 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS22470 823649528637cee1978b09ef0dd07a95 373 SUPERFAMILY SSF103481 202 284 3.01E-9 T 17-03-2017 SHXM_RS22470 823649528637cee1978b09ef0dd07a95 373 SUPERFAMILY SSF103481 35 133 3.27E-14 T 17-03-2017 SHXM_RS39640 cc892d2251bf2ca10fd7ca02b454ea95 277 Pfam PF08501 Shikimate dehydrogenase substrate binding domain 21 104 2.5E-16 T 17-03-2017 IPR013708 Shikimate dehydrogenase substrate binding, N-terminal GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 SHXM_RS39640 cc892d2251bf2ca10fd7ca02b454ea95 277 Pfam PF00899 ThiF family 131 169 2.3E-6 T 17-03-2017 IPR000594 THIF-type NAD/FAD binding fold GO:0008641 SHXM_RS39640 cc892d2251bf2ca10fd7ca02b454ea95 277 Gene3D G3DSA:3.40.50.720 125 255 7.2E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39640 cc892d2251bf2ca10fd7ca02b454ea95 277 SUPERFAMILY SSF51735 118 261 4.06E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39640 cc892d2251bf2ca10fd7ca02b454ea95 277 Gene3D G3DSA:3.40.192.10 12 124 1.2E-26 T 17-03-2017 SHXM_RS39640 cc892d2251bf2ca10fd7ca02b454ea95 277 SUPERFAMILY SSF53223 12 116 4.2E-22 T 17-03-2017 SHXM_RS23825 46698c257c2183ddcda4d4b3076fc473 391 Gene3D G3DSA:3.40.50.150 14 255 3.5E-47 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS23825 46698c257c2183ddcda4d4b3076fc473 391 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 100 214 3.7E-24 T 17-03-2017 SHXM_RS23825 46698c257c2183ddcda4d4b3076fc473 391 SUPERFAMILY SSF53335 5 61 1.91E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS23825 46698c257c2183ddcda4d4b3076fc473 391 SUPERFAMILY SSF53335 101 215 1.91E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS23825 46698c257c2183ddcda4d4b3076fc473 391 TIGRFAM TIGR04188 methyltr_grsp: methyltransferase, ATP-grasp peptide maturase system 12 376 3.4E-149 T 17-03-2017 IPR026448 Methyltransferase, ATP-grasp peptide maturase system SHXM_RS38035 10c713bcb99f484316769fd2a4fe3bbe 282 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 93 274 3.1E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38035 10c713bcb99f484316769fd2a4fe3bbe 282 SUPERFAMILY SSF161098 9 282 3.36E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38035 10c713bcb99f484316769fd2a4fe3bbe 282 Gene3D G3DSA:1.10.3720.10 9 270 3.4E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS30400 85fe4ecdf6ba2f22702cc20f67856587 408 Gene3D G3DSA:1.20.1250.20 17 176 8.9E-8 T 17-03-2017 SHXM_RS30400 85fe4ecdf6ba2f22702cc20f67856587 408 SUPERFAMILY SSF103473 5 389 1.57E-35 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS30400 85fe4ecdf6ba2f22702cc20f67856587 408 Pfam PF07690 Major Facilitator Superfamily 220 389 7.5E-13 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS30400 85fe4ecdf6ba2f22702cc20f67856587 408 Gene3D G3DSA:1.20.1250.20 213 382 1.1E-17 T 17-03-2017 SHXM_RS12025 7b2cc2ee7fbbc177f9d2404283c4c888 391 SUPERFAMILY SSF53383 6 365 1.32E-90 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS12025 7b2cc2ee7fbbc177f9d2404283c4c888 391 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 13 375 2.0E-101 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS12025 7b2cc2ee7fbbc177f9d2404283c4c888 391 PIRSF PIRSF000390 5 384 2.8E-97 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS12025 7b2cc2ee7fbbc177f9d2404283c4c888 391 Gene3D G3DSA:3.90.1150.10 246 383 1.3E-33 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS12025 7b2cc2ee7fbbc177f9d2404283c4c888 391 Gene3D G3DSA:3.40.640.10 10 245 8.6E-69 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS33345 266df9a63c19cf4647579eae92193376 219 Pfam PF13419 Haloacid dehalogenase-like hydrolase 47 177 1.7E-11 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS33345 266df9a63c19cf4647579eae92193376 219 SUPERFAMILY SSF56784 1 207 3.37E-36 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS33345 266df9a63c19cf4647579eae92193376 219 Gene3D G3DSA:3.40.50.1000 1 209 4.1E-31 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS33345 266df9a63c19cf4647579eae92193376 219 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 95 172 4.3E-8 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS44065 2fc84281b1e163641c050a5172dcf474 422 Gene3D G3DSA:1.20.1250.20 24 200 8.0E-15 T 17-03-2017 SHXM_RS44065 2fc84281b1e163641c050a5172dcf474 422 SUPERFAMILY SSF103473 14 386 3.27E-35 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS44065 2fc84281b1e163641c050a5172dcf474 422 Pfam PF06779 Uncharacterised MFS-type transporter YbfB 28 380 1.4E-73 T 17-03-2017 IPR010645 Uncharacterised MFS-type transporter YbfB SHXM_RS44065 2fc84281b1e163641c050a5172dcf474 422 Gene3D G3DSA:1.20.1250.20 216 386 5.2E-12 T 17-03-2017 SHXM_RS04635 b7c53a977bf839a2044b5c618dfae3d8 353 Gene3D G3DSA:3.10.310.10 178 327 6.4E-42 T 17-03-2017 SHXM_RS04635 b7c53a977bf839a2044b5c618dfae3d8 353 Gene3D G3DSA:3.10.310.10 6 177 7.2E-68 T 17-03-2017 SHXM_RS04635 b7c53a977bf839a2044b5c618dfae3d8 353 SUPERFAMILY SSF54506 6 167 5.23E-60 T 17-03-2017 SHXM_RS04635 b7c53a977bf839a2044b5c618dfae3d8 353 SUPERFAMILY SSF54506 170 350 1.67E-49 T 17-03-2017 SHXM_RS04635 b7c53a977bf839a2044b5c618dfae3d8 353 Pfam PF04303 PrpF protein 7 349 1.7E-100 T 17-03-2017 IPR007400 PrpF protein SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 SMART SM00487 20 239 4.6E-37 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 Gene3D G3DSA:3.40.50.300 269 430 1.9E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 SUPERFAMILY SSF52540 332 410 2.72E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 SUPERFAMILY SSF52540 34 210 2.72E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 SUPERFAMILY SSF52540 246 301 2.72E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 Gene3D G3DSA:3.40.50.300 16 206 1.6E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 SMART SM00490 320 401 5.9E-13 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 Pfam PF00271 Helicase conserved C-terminal domain 277 401 3.0E-11 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 Pfam PF00270 DEAD/DEAH box helicase 25 208 8.7E-28 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS37205 6611ba3d9089f1f2b8f00bcc52eaa5b5 1554 Pfam PF08494 DEAD/H associated 665 874 1.1E-77 T 17-03-2017 IPR013701 DEAD/H associated GO:0005524|GO:0016818 SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 Pfam PF01614 Bacterial transcriptional regulator 162 281 7.4E-28 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 SUPERFAMILY SSF55781 97 281 7.19E-43 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 Gene3D G3DSA:1.10.10.10 35 110 2.1E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 SUPERFAMILY SSF46785 41 110 1.57E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 Gene3D G3DSA:3.30.450.40 115 282 2.8E-44 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 Pfam PF09339 IclR helix-turn-helix domain 42 92 1.4E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS00340 4f45dc7c3174ea6f0c3d00f803423ea8 296 SMART SM00346 40 129 4.1E-23 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS14415 ccea868bfbc6eb75326d63fbd327464d 82 Pfam PF04149 Domain of unknown function (DUF397) 29 80 2.9E-21 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 SUPERFAMILY SSF51338 309 341 2.07E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 SUPERFAMILY SSF51338 4 62 2.07E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 Gene3D G3DSA:2.30.40.10 247 344 1.0E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 SUPERFAMILY SSF51556 62 309 2.31E-24 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 Pfam PF01979 Amidohydrolase family 59 340 2.4E-24 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 Gene3D G3DSA:2.30.40.10 7 102 4.7E-18 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 Hamap MF_01518 Adenine deaminase [ade]. 8 559 31.585 T 17-03-2017 IPR006679 Adenine deaminase GO:0000034|GO:0006146 KEGG: 00230+3.5.4.2|MetaCyc: PWY-6610 SHXM_RS12940 d2ed013b289185c0477971fa54646a31 562 Pfam PF13382 Adenine deaminase C-terminal domain 391 553 6.3E-48 T 17-03-2017 IPR026912 Adenine deaminase C-terminal domain KEGG: 00230+3.5.4.2|MetaCyc: PWY-6610 SHXM_RS09155 a9492f96853b54dc67cef031974ef631 345 Gene3D G3DSA:1.10.10.10 2 87 1.0E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09155 a9492f96853b54dc67cef031974ef631 345 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 2 65 4.6E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS09155 a9492f96853b54dc67cef031974ef631 345 SUPERFAMILY SSF46785 2 100 2.99E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 Gene3D G3DSA:1.10.10.10 8 54 5.3E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 ProSitePatterns PS00519 AsnC-type HTH domain signature. 25 51 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 SMART SM00344 7 113 1.5E-24 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 Pfam PF01037 Lrp/AsnC ligand binding domain 76 143 1.0E-15 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 23 34 4.4E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 34 53 4.4E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 7 23 4.4E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 SUPERFAMILY SSF54909 68 152 2.82E-18 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 SUPERFAMILY SSF46785 5 84 6.18E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 Pfam PF13404 AsnC-type helix-turn-helix domain 8 48 2.4E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44325 c384fe17c0f262524166b46128a01014 160 Gene3D G3DSA:3.30.70.920 60 150 9.4E-21 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 SUPERFAMILY SSF47413 11 67 2.33E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 Pfam PF00356 Bacterial regulatory proteins, lacI family 13 56 2.1E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 Gene3D G3DSA:1.10.260.40 11 60 2.4E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 Gene3D G3DSA:3.40.50.2300 181 313 5.3E-41 T 17-03-2017 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 ProSitePatterns PS00356 LacI-type HTH domain signature. 13 31 - T 17-03-2017 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 Gene3D G3DSA:3.40.50.2300 61 180 1.5E-41 T 17-03-2017 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 Pfam PF13377 Periplasmic binding protein-like domain 177 335 2.1E-35 T 17-03-2017 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 SMART SM00354 10 80 7.3E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS50405 5a6d04ddf9bee8434bf3f076dcab8aab 339 SUPERFAMILY SSF53822 70 336 1.34E-66 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS43105 403f34617b3924305a42252a8037c350 279 Gene3D G3DSA:3.40.50.720 34 273 1.4E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43105 403f34617b3924305a42252a8037c350 279 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 178 206 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS43105 403f34617b3924305a42252a8037c350 279 SUPERFAMILY SSF51735 35 274 7.42E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS43105 403f34617b3924305a42252a8037c350 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 41 58 4.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43105 403f34617b3924305a42252a8037c350 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 181 4.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43105 403f34617b3924305a42252a8037c350 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 117 128 4.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43105 403f34617b3924305a42252a8037c350 279 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 191 210 4.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS43105 403f34617b3924305a42252a8037c350 279 Pfam PF00106 short chain dehydrogenase 41 210 5.6E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 SUPERFAMILY SSF50494 279 509 2.56E-55 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 Pfam PF13180 PDZ domain 504 593 5.5E-20 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 PRINTS PR00834 HtrA/DegQ protease family signature 319 331 1.9E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 PRINTS PR00834 HtrA/DegQ protease family signature 542 554 1.9E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 PRINTS PR00834 HtrA/DegQ protease family signature 384 408 1.9E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 PRINTS PR00834 HtrA/DegQ protease family signature 343 363 1.9E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 PRINTS PR00834 HtrA/DegQ protease family signature 449 466 1.9E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 PRINTS PR00834 HtrA/DegQ protease family signature 427 444 1.9E-44 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 SMART SM00228 504 584 1.9E-6 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 Gene3D G3DSA:2.40.10.10 305 383 7.4E-28 T 17-03-2017 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 Gene3D G3DSA:2.30.42.10 507 597 3.1E-19 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 Pfam PF13365 Trypsin-like peptidase domain 310 456 1.7E-35 T 17-03-2017 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 Gene3D G3DSA:2.40.10.10 384 506 7.4E-43 T 17-03-2017 SHXM_RS34110 7a6fc4e2d66eacf418f84241d2f79410 599 SUPERFAMILY SSF50156 485 593 6.7E-18 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS09810 3742573cb7efc28eb3d987fdc56ac2cd 218 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 47 192 2.2E-17 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS09810 3742573cb7efc28eb3d987fdc56ac2cd 218 SUPERFAMILY SSF160631 142 196 1.83E-11 T 17-03-2017 SHXM_RS09810 3742573cb7efc28eb3d987fdc56ac2cd 218 SUPERFAMILY SSF160631 40 111 1.83E-11 T 17-03-2017 SHXM_RS09810 3742573cb7efc28eb3d987fdc56ac2cd 218 SMART SM00860 46 193 1.9E-7 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 SMART SM00829 10 329 2.4E-16 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 92 3.8E-8 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 Pfam PF13602 Zinc-binding dehydrogenase 209 329 9.0E-26 T 17-03-2017 SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 Gene3D G3DSA:3.40.50.720 176 304 8.8E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 Gene3D G3DSA:3.90.180.10 1 175 3.6E-47 T 17-03-2017 IPR011032 GroES-like SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 SUPERFAMILY SSF51735 124 257 2.87E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS20110 6079d82236aa4dd43ed83a6be5a9fa91 332 SUPERFAMILY SSF50129 1 149 4.41E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS42290 a3af3ba8049890a7f64c0464f14436dd 197 SUPERFAMILY SSF55729 17 142 4.94E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS42290 a3af3ba8049890a7f64c0464f14436dd 197 Pfam PF13527 Acetyltransferase (GNAT) domain 18 138 1.1E-8 T 17-03-2017 SHXM_RS42290 a3af3ba8049890a7f64c0464f14436dd 197 Gene3D G3DSA:3.40.630.30 16 150 1.6E-17 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS44155 b14724f0749ed92ec80a5c7937872275 282 PIRSF PIRSF016184 5 282 3.0E-69 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS44155 b14724f0749ed92ec80a5c7937872275 282 SUPERFAMILY SSF54506 8 282 5.41E-74 T 17-03-2017 SHXM_RS44155 b14724f0749ed92ec80a5c7937872275 282 Gene3D G3DSA:3.10.310.10 129 270 5.0E-39 T 17-03-2017 SHXM_RS44155 b14724f0749ed92ec80a5c7937872275 282 Pfam PF02567 Phenazine biosynthesis-like protein 12 276 9.3E-61 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS44155 b14724f0749ed92ec80a5c7937872275 282 Gene3D G3DSA:3.10.310.10 7 126 1.7E-42 T 17-03-2017 SHXM_RS44155 b14724f0749ed92ec80a5c7937872275 282 TIGRFAM TIGR00654 PhzF_family: phenazine biosynthesis protein, PhzF family 8 280 1.4E-57 T 17-03-2017 IPR003719 Phenazine biosynthesis PhzF protein GO:0003824|GO:0009058 SHXM_RS39380 dd15e565cdbbd0c6eacc5618811f00ff 213 Gene3D G3DSA:3.20.20.70 2 212 3.2E-62 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS39380 dd15e565cdbbd0c6eacc5618811f00ff 213 SUPERFAMILY SSF51569 3 207 9.34E-54 T 17-03-2017 SHXM_RS39380 dd15e565cdbbd0c6eacc5618811f00ff 213 Pfam PF01081 KDPG and KHG aldolase 17 190 1.2E-33 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS06360 ef99a2af00be7822c553b3267985a84a 122 SUPERFAMILY SSF52833 2 119 3.05E-27 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS06360 ef99a2af00be7822c553b3267985a84a 122 Gene3D G3DSA:3.40.30.10 1 119 2.1E-38 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS06360 ef99a2af00be7822c553b3267985a84a 122 Pfam PF03960 ArsC family 54 115 9.9E-11 T 17-03-2017 IPR006660 Arsenate reductase-like SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 PRINTS PR00773 GrpE protein signature 149 164 7.2E-18 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 PRINTS PR00773 GrpE protein signature 69 85 7.2E-18 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 PRINTS PR00773 GrpE protein signature 97 112 7.2E-18 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 PRINTS PR00773 GrpE protein signature 176 195 7.2E-18 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 SUPERFAMILY SSF51064 146 197 1.15E-12 T 17-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 SUPERFAMILY SSF58014 52 141 5.89E-20 T 17-03-2017 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 Pfam PF01025 GrpE 58 197 5.5E-34 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 Gene3D G3DSA:3.90.20.20 52 139 6.4E-21 T 17-03-2017 IPR013805 GrpE nucleotide exchange factor, coiled-coil Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 Hamap MF_01151 Protein GrpE [grpE]. 6 197 16.605 T 17-03-2017 IPR000740 GrpE nucleotide exchange factor GO:0000774|GO:0006457|GO:0042803|GO:0051087 Reactome: R-HSA-1268020 SHXM_RS40015 b55053d1229319bfd584d0e9caedb899 199 Gene3D G3DSA:2.30.22.10 141 198 2.4E-17 T 17-03-2017 IPR009012 GrpE nucleotide exchange factor, head GO:0006457 Reactome: R-HSA-1268020 SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 SUPERFAMILY SSF56801 2 494 1.22E-163 T 17-03-2017 SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 Gene3D G3DSA:3.30.300.30 397 492 7.1E-33 T 17-03-2017 SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 Pfam PF13193 AMP-binding enzyme C-terminal domain 411 486 5.8E-20 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 Gene3D G3DSA:2.30.38.10 322 393 4.6E-29 T 17-03-2017 SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 Gene3D G3DSA:3.40.50.980 3 160 8.5E-42 T 17-03-2017 SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 ProSitePatterns PS00455 Putative AMP-binding domain signature. 156 167 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 Gene3D G3DSA:3.40.50.980 161 321 1.3E-48 T 17-03-2017 SHXM_RS48225 7ab8dcf29eb9a05f305c4d000b552d7d 496 Pfam PF00501 AMP-binding enzyme 15 402 1.9E-110 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS01845 1ee513cba3d87d1183a41af14da74226 157 Pfam PF13577 SnoaL-like domain 14 137 4.5E-19 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS01845 1ee513cba3d87d1183a41af14da74226 157 SUPERFAMILY SSF54427 10 142 6.11E-30 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS01845 1ee513cba3d87d1183a41af14da74226 157 Gene3D G3DSA:3.10.450.50 11 148 9.3E-26 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 Hamap MF_01976 Pyrophosphate--fructose 6-phosphate 1-phosphotransferase [pfp]. 1 341 43.006 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 Pfam PF00365 Phosphofructokinase 2 297 1.5E-100 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 TIGRFAM TIGR02483 PFK_mixed: phosphofructokinase 2 323 9.4E-144 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 SUPERFAMILY SSF53784 1 332 7.06E-120 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 93 109 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 5 24 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 212 224 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 120 137 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 31 44 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 138 156 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 158 174 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 262 284 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 176 193 7.9E-74 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 PIRSF PIRSF000532 1 340 4.5E-115 T 17-03-2017 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 ProSitePatterns PS00433 Phosphofructokinase signature. 266 284 - T 17-03-2017 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS35535 cfc923e667f404981d8595b022ae923a 341 Gene3D G3DSA:3.40.50.450 1 213 1.9E-72 T 17-03-2017 SHXM_RS15720 26f724f190a64a6892f59c900530b36c 251 Pfam PF13676 TIR domain 4 122 1.2E-11 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS15720 26f724f190a64a6892f59c900530b36c 251 SUPERFAMILY SSF52200 3 100 1.09E-7 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS15720 26f724f190a64a6892f59c900530b36c 251 Gene3D G3DSA:3.40.50.10140 4 92 4.2E-4 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 SUPERFAMILY SSF48256 3 429 3.27E-160 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PIRSF PIRSF001369 37 429 7.0E-155 T 17-03-2017 IPR024176 Citrate synthase, bacterial-type SHXM_RS22315 5540596c991f97445e86c780a696309f 429 Pfam PF00285 Citrate synthase, C-terminal domain 46 412 1.0E-134 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 Gene3D G3DSA:1.10.580.10 52 281 6.8E-96 T 17-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 ProSitePatterns PS00480 Citrate synthase signature. 304 316 - T 17-03-2017 IPR019810 Citrate synthase active site GO:0006099|GO:0046912 Reactome: R-HSA-1268020|Reactome: R-HSA-71403 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 Gene3D G3DSA:1.10.230.10 282 374 4.3E-36 T 17-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 TIGRFAM TIGR01798 cit_synth_I: citrate (Si)-synthase 14 423 5.6E-183 T 17-03-2017 IPR010953 Citrate synthase, type I GO:0004108|GO:0005737 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PRINTS PR00143 Citrate synthase signature 297 317 2.7E-54 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PRINTS PR00143 Citrate synthase signature 380 394 2.7E-54 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PRINTS PR00143 Citrate synthase signature 219 234 2.7E-54 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PRINTS PR00143 Citrate synthase signature 241 269 2.7E-54 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PRINTS PR00143 Citrate synthase signature 165 178 2.7E-54 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS22315 5540596c991f97445e86c780a696309f 429 PRINTS PR00143 Citrate synthase signature 360 376 2.7E-54 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Gene3D G3DSA:1.10.1060.10 471 625 9.0E-13 T 17-03-2017 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Pfam PF02913 FAD linked oxidases, C-terminal domain 257 491 1.9E-49 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Gene3D G3DSA:3.30.465.10 97 257 2.2E-34 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Pfam PF01565 FAD binding domain 42 178 1.4E-38 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 SUPERFAMILY SSF55103 260 501 1.39E-51 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 SUPERFAMILY SSF56176 7 257 4.5E-59 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 SUPERFAMILY SSF46548 531 614 9.42E-8 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Pfam PF13183 4Fe-4S dicluster domain 530 610 2.7E-9 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Gene3D G3DSA:3.30.43.10 7 94 1.1E-21 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS25645 47e83f9780cae83ba52ae48038092dc6 940 Pfam PF02754 Cysteine-rich domain 718 793 0.0037 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS50290 97ac20f68f55015217383807066d81f1 482 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 14 277 9.8E-29 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS50290 97ac20f68f55015217383807066d81f1 482 SUPERFAMILY SSF53649 14 419 1.6E-47 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS50290 97ac20f68f55015217383807066d81f1 482 Gene3D G3DSA:3.40.720.10 14 271 1.7E-35 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 SUPERFAMILY SSF56645 4 234 4.58E-58 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 126 223 4.0E-24 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 10 115 1.3E-14 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 SUPERFAMILY SSF47203 258 404 1.47E-53 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 361 380 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 Gene3D G3DSA:1.10.540.10 3 115 1.2E-24 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 258 402 3.8E-53 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 Gene3D G3DSA:2.40.110.10 125 222 9.9E-36 T 17-03-2017 SHXM_RS08380 ad8de372f3b64a29079f28c15d5dcaeb 408 Gene3D G3DSA:1.20.140.10 223 404 7.6E-65 T 17-03-2017 SHXM_RS27170 add64d5deb2840ceda5d2951117b45ec 365 Gene3D G3DSA:3.40.1130.10 56 237 2.7E-11 T 17-03-2017 SHXM_RS27170 add64d5deb2840ceda5d2951117b45ec 365 SMART SM00563 77 202 7.4E-10 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS27170 add64d5deb2840ceda5d2951117b45ec 365 SUPERFAMILY SSF69593 47 229 1.7E-24 T 17-03-2017 SHXM_RS27170 add64d5deb2840ceda5d2951117b45ec 365 Pfam PF01553 Acyltransferase 71 189 1.4E-15 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS44700 7ac8fdef08f9100228405bd9d4a8775c 412 SMART SM00530 12 65 3.4E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS44700 7ac8fdef08f9100228405bd9d4a8775c 412 SUPERFAMILY SSF47413 8 70 2.79E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS44700 7ac8fdef08f9100228405bd9d4a8775c 412 Gene3D G3DSA:1.25.40.10 149 360 6.5E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44700 7ac8fdef08f9100228405bd9d4a8775c 412 Gene3D G3DSA:1.10.260.40 9 71 5.9E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10065 4f4951f9fe7f33b49aa670a41c14d6b0 602 Pfam PF05762 VWA domain containing CoxE-like protein 375 564 3.4E-9 T 17-03-2017 IPR008912 Uncharacterised protein family CoxE-like SHXM_RS10065 4f4951f9fe7f33b49aa670a41c14d6b0 602 SUPERFAMILY SSF53300 433 569 8.16E-9 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS31770 cbc073131458fc716f90de52304d56d1 215 Pfam PF00440 Bacterial regulatory proteins, tetR family 31 62 1.5E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31770 cbc073131458fc716f90de52304d56d1 215 SUPERFAMILY SSF48498 93 203 1.95E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS31770 cbc073131458fc716f90de52304d56d1 215 SUPERFAMILY SSF46689 15 77 2.46E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31770 cbc073131458fc716f90de52304d56d1 215 Gene3D G3DSA:1.10.357.10 12 191 1.3E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS31615 3258a6fb74fca44756c049e9923911ef 403 Gene3D G3DSA:3.40.710.10 67 385 3.8E-72 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS31615 3258a6fb74fca44756c049e9923911ef 403 Pfam PF00144 Beta-lactamase 59 384 6.2E-58 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS31615 3258a6fb74fca44756c049e9923911ef 403 SUPERFAMILY SSF56601 57 383 1.21E-72 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 Gene3D G3DSA:2.40.10.10 150 226 1.0E-28 T 17-03-2017 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 Pfam PF13365 Trypsin-like peptidase domain 155 327 1.4E-28 T 17-03-2017 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 SUPERFAMILY SSF50494 132 258 6.55E-50 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 SUPERFAMILY SSF50494 296 368 6.55E-50 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 PRINTS PR00834 HtrA/DegQ protease family signature 185 205 1.6E-26 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 PRINTS PR00834 HtrA/DegQ protease family signature 164 176 1.6E-26 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 PRINTS PR00834 HtrA/DegQ protease family signature 320 337 1.6E-26 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 PRINTS PR00834 HtrA/DegQ protease family signature 298 315 1.6E-26 T 17-03-2017 IPR001940 Peptidase S1C GO:0004252|GO:0006508 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 Gene3D G3DSA:2.40.10.10 298 368 2.1E-38 T 17-03-2017 SHXM_RS30140 f0b6f84080bbb063128bac1398d6fca6 373 Gene3D G3DSA:2.40.10.10 227 260 2.1E-38 T 17-03-2017 SHXM_RS27520 00be1c402a0a63b35d2686295f596f2f 83 Gene3D G3DSA:1.10.443.10 20 62 1.8E-7 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS27520 00be1c402a0a63b35d2686295f596f2f 83 SUPERFAMILY SSF56349 20 59 1.88E-7 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 Gene3D G3DSA:1.10.601.10 27 110 8.6E-17 T 17-03-2017 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 Gene3D G3DSA:1.10.10.10 210 274 1.5E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 Pfam PF04542 Sigma-70 region 2 47 119 2.0E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 43 272 1.2E-37 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 SUPERFAMILY SSF88659 186 274 6.17E-25 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 74 87 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 Pfam PF04539 Sigma-70 region 3 127 207 1.4E-7 T 17-03-2017 IPR007624 RNA polymerase sigma-70 region 3 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 SUPERFAMILY SSF88946 18 119 5.18E-26 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 242 268 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 TIGRFAM TIGR02479 FliA_WhiG: RNA polymerase sigma factor, FliA/WhiG family 47 272 4.1E-88 T 17-03-2017 IPR012845 RNA polymerase sigma factor, FliA/WhiG GO:0003677|GO:0003899|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 Pfam PF04545 Sigma-70, region 4 221 270 6.1E-19 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 PRINTS PR00046 Major sigma-70 factor signature 225 237 2.0E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 PRINTS PR00046 Major sigma-70 factor signature 257 268 2.0E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 PRINTS PR00046 Major sigma-70 factor signature 74 87 2.0E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 PRINTS PR00046 Major sigma-70 factor signature 242 257 2.0E-12 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 SUPERFAMILY SSF88659 120 199 5.67E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 Gene3D G3DSA:1.10.10.10 119 163 5.7E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36640 eedfaee2fdb9508ce3d65af819defffc 277 PIRSF PIRSF000770 24 276 8.1E-77 T 17-03-2017 IPR016263 RNA polymerase sporulation-specific sigma factor GO:0003677|GO:0006351|GO:0016987|GO:0030435 SHXM_RS17845 036f58eecec417927218a4db9312224c 257 Pfam PF01061 ABC-2 type transporter 29 224 3.0E-21 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS17845 036f58eecec417927218a4db9312224c 257 PIRSF PIRSF006648 3 257 3.8E-30 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 SUPERFAMILY SSF51735 4 258 6.59E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 11 28 1.3E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 86 97 1.3E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 1.3E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 1.3E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 1.3E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 Pfam PF00106 short chain dehydrogenase 11 197 1.5E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 3.1E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 3.1E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 86 97 3.1E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 Gene3D G3DSA:3.40.50.720 3 239 9.3E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39205 6bbb336570ad2f38027aec4cc4d53462 267 PIRSF PIRSF000126 1 264 2.2E-63 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 Hamap MF_00197 Diaminopimelate epimerase [dapF]. 7 302 31.359 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 Gene3D G3DSA:3.10.310.10 7 148 9.1E-39 T 17-03-2017 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 TIGRFAM TIGR00652 DapF: diaminopimelate epimerase 8 300 1.8E-65 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 ProSitePatterns PS01326 Diaminopimelate epimerase signature. 78 92 - T 17-03-2017 IPR018510 Diaminopimelate epimerase, active site GO:0005737|GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 Pfam PF01678 Diaminopimelate epimerase 9 131 6.7E-33 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 Pfam PF01678 Diaminopimelate epimerase 174 295 1.8E-28 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 SUPERFAMILY SSF54506 160 300 1.24E-35 T 17-03-2017 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 Gene3D G3DSA:3.10.310.10 149 290 8.6E-39 T 17-03-2017 SHXM_RS37340 cc146f606374770175206562ce9a47f1 310 SUPERFAMILY SSF54506 7 127 1.1E-31 T 17-03-2017 SHXM_RS08785 747d4bfb3e05d22c512c73f8fdc18cf9 800 Pfam PF01935 Domain of unknown function DUF87 398 476 1.4E-6 T 17-03-2017 IPR002789 Helicase HerA, central domain SHXM_RS08785 747d4bfb3e05d22c512c73f8fdc18cf9 800 SUPERFAMILY SSF52540 375 759 4.07E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08785 747d4bfb3e05d22c512c73f8fdc18cf9 800 Gene3D G3DSA:3.40.50.300 392 481 2.5E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08785 747d4bfb3e05d22c512c73f8fdc18cf9 800 Gene3D G3DSA:3.40.50.300 608 757 2.5E-31 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08785 747d4bfb3e05d22c512c73f8fdc18cf9 800 Pfam PF12696 TraM recognition site of TraD and TraG 663 726 1.2E-5 T 17-03-2017 IPR032689 TraD/TraG, TraM recognition site SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 PIRSF PIRSF000144 1 763 0.0 T 17-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 Gene3D G3DSA:2.40.40.20 643 759 3.1E-9 T 17-03-2017 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 SUPERFAMILY SSF50692 643 761 1.37E-16 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 Pfam PF00384 Molybdopterin oxidoreductase 120 523 1.1E-24 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 SUPERFAMILY SSF53706 58 634 3.14E-129 T 17-03-2017 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 Gene3D G3DSA:3.40.228.10 194 400 1.0E-48 T 17-03-2017 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 TIGRFAM TIGR01701 Fdhalpha-like: oxidoreductase alpha (molybdopterin) subunit 22 760 1.5E-270 T 17-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 Pfam PF01568 Molydopterin dinucleotide binding domain 647 753 8.0E-9 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 Gene3D G3DSA:3.40.50.740 120 193 1.2E-51 T 17-03-2017 SHXM_RS46380 68e1445365ed6f8a55de9017b576f711 763 Gene3D G3DSA:3.40.50.740 401 632 1.2E-51 T 17-03-2017 SHXM_RS05585 88a3823f7a9266de5cf76b820251bb67 428 Gene3D G3DSA:1.10.630.10 29 422 1.0E-71 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05585 88a3823f7a9266de5cf76b820251bb67 428 SUPERFAMILY SSF48264 17 422 7.47E-48 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05585 88a3823f7a9266de5cf76b820251bb67 428 PRINTS PR00359 B-class P450 signature 215 237 5.0E-18 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05585 88a3823f7a9266de5cf76b820251bb67 428 PRINTS PR00359 B-class P450 signature 358 367 5.0E-18 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05585 88a3823f7a9266de5cf76b820251bb67 428 PRINTS PR00359 B-class P450 signature 162 178 5.0E-18 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05585 88a3823f7a9266de5cf76b820251bb67 428 PRINTS PR00359 B-class P450 signature 311 338 5.0E-18 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS06875 e1eb6617cc8466130096e40a6af41359 258 SMART SM00987 63 241 1.9E-29 T 17-03-2017 SHXM_RS06875 e1eb6617cc8466130096e40a6af41359 258 SUPERFAMILY SSF52141 31 244 1.9E-42 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06875 e1eb6617cc8466130096e40a6af41359 258 Pfam PF03167 Uracil DNA glycosylase superfamily 63 241 2.7E-29 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06875 e1eb6617cc8466130096e40a6af41359 258 Gene3D G3DSA:3.40.470.10 20 247 4.5E-54 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS06875 e1eb6617cc8466130096e40a6af41359 258 SMART SM00986 63 241 1.9E-29 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS01885 bfe6c41b3471befa0e48348b8c7f500b 132 SUPERFAMILY SSF46785 15 122 6.4E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01885 bfe6c41b3471befa0e48348b8c7f500b 132 Pfam PF01638 HxlR-like helix-turn-helix 31 113 2.5E-23 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS01885 bfe6c41b3471befa0e48348b8c7f500b 132 Gene3D G3DSA:1.10.10.10 12 129 2.5E-40 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32090 6dc5d5a45730c2d43b42eb6a151acd09 188 SUPERFAMILY SSF51735 21 183 6.53E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32090 6dc5d5a45730c2d43b42eb6a151acd09 188 Gene3D G3DSA:3.40.50.720 22 179 1.1E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03515 6ff3461cc325b9e7f7c9e21ede07d3d0 525 SUPERFAMILY SSF53850 54 514 4.34E-96 T 17-03-2017 SHXM_RS03515 6ff3461cc325b9e7f7c9e21ede07d3d0 525 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 99 408 1.1E-62 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS03515 6ff3461cc325b9e7f7c9e21ede07d3d0 525 Gene3D G3DSA:3.90.76.10 65 210 5.5E-35 T 17-03-2017 SHXM_RS03515 6ff3461cc325b9e7f7c9e21ede07d3d0 525 Gene3D G3DSA:3.10.105.10 309 495 1.0E-30 T 17-03-2017 SHXM_RS03515 6ff3461cc325b9e7f7c9e21ede07d3d0 525 Gene3D G3DSA:3.40.190.10 211 308 2.5E-26 T 17-03-2017 SHXM_RS03515 6ff3461cc325b9e7f7c9e21ede07d3d0 525 PIRSF PIRSF002741 23 520 2.0E-68 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 343 550 2.1E-37 T 17-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 SUPERFAMILY SSF55186 64 258 6.54E-51 T 17-03-2017 IPR018163 Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain GO:0000166 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Gene3D G3DSA:3.30.930.10 259 551 2.9E-103 T 17-03-2017 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Gene3D G3DSA:3.40.50.800 552 656 1.1E-30 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Hamap MF_00184 Threonine--tRNA ligase [thrS]. 66 655 32.975 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Gene3D G3DSA:3.30.54.20 132 204 1.1E-10 T 17-03-2017 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Pfam PF03129 Anticodon binding domain 562 650 5.1E-19 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Pfam PF07973 Threonyl and Alanyl tRNA synthetase second additional domain 191 236 6.5E-13 T 17-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 SMART SM00863 180 236 2.3E-19 T 17-03-2017 IPR012947 Threonyl/alanyl tRNA synthetase, SAD GO:0005524|GO:0016876|GO:0043039 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 SUPERFAMILY SSF52954 550 654 1.96E-27 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 TIGRFAM TIGR00418 thrS: threonine--tRNA ligase 72 650 3.0E-195 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Gene3D G3DSA:3.30.980.10 66 129 8.4E-42 T 17-03-2017 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 Gene3D G3DSA:3.30.980.10 205 241 8.4E-42 T 17-03-2017 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 PRINTS PR01047 Threonyl-tRNA synthetase signature 485 513 2.3E-49 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 PRINTS PR01047 Threonyl-tRNA synthetase signature 348 376 2.3E-49 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 PRINTS PR01047 Threonyl-tRNA synthetase signature 555 567 2.3E-49 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 PRINTS PR01047 Threonyl-tRNA synthetase signature 381 404 2.3E-49 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 PRINTS PR01047 Threonyl-tRNA synthetase signature 528 541 2.3E-49 T 17-03-2017 IPR002320 Threonine-tRNA ligase, class IIa GO:0004829|GO:0005524|GO:0005737|GO:0006435 KEGG: 00970+6.1.1.3 SHXM_RS12605 2bfe669e732b81f749f6afa4ecf571f3 659 SUPERFAMILY SSF55681 260 547 1.12E-89 T 17-03-2017 SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 42 56 5.0E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 56 72 5.0E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 Gene3D G3DSA:1.10.10.10 12 83 5.3E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 SMART SM00866 114 253 1.4E-25 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 SMART SM00345 23 82 8.6E-24 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 SUPERFAMILY SSF46785 11 94 1.44E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 SUPERFAMILY SSF64288 70 258 8.48E-35 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 Gene3D G3DSA:3.40.1410.10 84 256 2.9E-60 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 Pfam PF07702 UTRA domain 115 252 1.2E-30 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS29580 b0c332d116e2814f677cfe250bb878b2 261 Pfam PF00392 Bacterial regulatory proteins, gntR family 21 82 5.4E-23 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34265 ac3a61607a4b7b98f2c1392a87479c32 921 SUPERFAMILY SSF56112 302 452 2.81E-7 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS34265 ac3a61607a4b7b98f2c1392a87479c32 921 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 622 908 2.4E-31 T 17-03-2017 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SHXM_RS34265 ac3a61607a4b7b98f2c1392a87479c32 921 Gene3D G3DSA:1.10.510.10 383 452 7.1E-5 T 17-03-2017 SHXM_RS34265 ac3a61607a4b7b98f2c1392a87479c32 921 TIGRFAM TIGR00374 TIGR00374: TIGR00374 family protein 644 915 4.6E-14 T 17-03-2017 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SHXM_RS19670 9b8a49dd1a825493b564b1792bf2d6a9 356 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 11 351 3.4E-90 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS19670 9b8a49dd1a825493b564b1792bf2d6a9 356 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 245 264 - T 17-03-2017 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-71403 SHXM_RS19670 9b8a49dd1a825493b564b1792bf2d6a9 356 Gene3D G3DSA:3.40.718.10 6 354 2.6E-118 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS19670 9b8a49dd1a825493b564b1792bf2d6a9 356 SUPERFAMILY SSF53659 6 354 9.9E-119 T 17-03-2017 SHXM_RS19670 9b8a49dd1a825493b564b1792bf2d6a9 356 SMART SM01329 10 352 6.3E-172 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS19670 9b8a49dd1a825493b564b1792bf2d6a9 356 TIGRFAM TIGR02089 TTC: tartrate dehydrogenase 8 355 2.4E-164 T 17-03-2017 IPR011829 Tartrate dehydrogenase GO:0016616|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.93|KEGG: 00650+1.1.1.83 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SUPERFAMILY SSF48452 276 402 1.67E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 Gene3D G3DSA:1.25.40.10 291 405 7.2E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 Gene3D G3DSA:1.25.40.10 106 290 9.3E-24 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 Pfam PF13424 Tetratricopeptide repeat 114 186 4.8E-9 T 17-03-2017 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 Pfam PF13424 Tetratricopeptide repeat 194 265 1.5E-7 T 17-03-2017 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 Pfam PF13424 Tetratricopeptide repeat 278 345 4.6E-9 T 17-03-2017 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SMART SM00028 114 147 280.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SMART SM00028 194 227 29.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SMART SM00028 154 187 24.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SMART SM00028 314 347 11.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SMART SM00028 274 307 15.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SMART SM00028 234 267 160.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS24450 ab9d3ee9a7ccab883dbde23ae7bb2a85 417 SUPERFAMILY SSF48452 106 269 1.27E-19 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36415 530449345935578ee51abe7cb55110f2 61 Pfam PF00830 Ribosomal L28 family 4 58 9.9E-25 T 17-03-2017 IPR026569 Ribosomal protein L28/L24 GO:0003735 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS36415 530449345935578ee51abe7cb55110f2 61 SUPERFAMILY SSF143800 2 59 2.16E-24 T 17-03-2017 SHXM_RS36415 530449345935578ee51abe7cb55110f2 61 Gene3D G3DSA:2.30.170.40 3 58 6.5E-24 T 17-03-2017 SHXM_RS36415 530449345935578ee51abe7cb55110f2 61 Hamap MF_00373 50S ribosomal protein L28 [rpmB]. 1 61 17.533 T 17-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36415 530449345935578ee51abe7cb55110f2 61 TIGRFAM TIGR00009 L28: ribosomal protein bL28 2 56 1.0E-24 T 17-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 Pfam PF00392 Bacterial regulatory proteins, gntR family 4 66 1.1E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 SMART SM00345 7 66 2.4E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 Pfam PF00155 Aminotransferase class I and II 124 427 6.3E-12 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 SUPERFAMILY SSF53383 62 432 3.6E-59 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 Gene3D G3DSA:1.10.10.10 4 67 2.8E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 Gene3D G3DSA:3.90.1150.10 329 431 1.1E-4 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 Gene3D G3DSA:3.40.640.10 122 328 1.9E-37 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS09505 872d63b3acbca5b03d836c01de5968ab 442 SUPERFAMILY SSF46785 4 79 7.35E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14695 518224d625c628170f4e329062b4be2e 150 PIRSF PIRSF017371 1 147 1.7E-70 T 17-03-2017 IPR014488 Uncharacterised conserved protein UCP017371 SHXM_RS14695 518224d625c628170f4e329062b4be2e 150 Gene3D G3DSA:3.30.530.20 3 116 2.1E-7 T 17-03-2017 IPR023393 START-like domain SHXM_RS14695 518224d625c628170f4e329062b4be2e 150 SUPERFAMILY SSF55961 3 141 8.54E-20 T 17-03-2017 SHXM_RS14695 518224d625c628170f4e329062b4be2e 150 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 4 145 2.3E-23 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS21150 22d77e1444cd866b2564c0cae9efd3f3 121 SUPERFAMILY SSF142906 2 118 5.49E-39 T 17-03-2017 SHXM_RS21150 22d77e1444cd866b2564c0cae9efd3f3 121 Pfam PF04237 YjbR 11 105 1.9E-28 T 17-03-2017 IPR007351 Uncharacterised protein YjbR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 Gene3D G3DSA:3.40.50.720 2 243 5.8E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 SUPERFAMILY SSF51735 2 243 2.66E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 2.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 2.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 2.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 2.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 2.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 207 227 2.9E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 243 7.2E-44 T 17-03-2017 SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 151 170 4.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 4.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07850 42d70202e8473b5502db04a283bff8fc 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 4.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 SUPERFAMILY SSF53822 79 341 1.18E-56 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 SMART SM00354 16 85 8.8E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 Pfam PF13377 Periplasmic binding protein-like domain 180 339 9.1E-40 T 17-03-2017 SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 SUPERFAMILY SSF47413 15 74 6.19E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 Gene3D G3DSA:3.40.50.2300 74 177 2.1E-18 T 17-03-2017 SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 Gene3D G3DSA:1.10.260.40 18 73 5.8E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 Pfam PF00356 Bacterial regulatory proteins, lacI family 19 61 2.4E-9 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS46700 47b4c6ecf45c4c0b6b1d663f394e1070 343 Gene3D G3DSA:3.40.50.2300 178 340 5.3E-50 T 17-03-2017 SHXM_RS25510 91e8be5f28f19b2b38be083a9bf73f39 436 Gene3D G3DSA:3.40.50.2300 43 227 1.0E-17 T 17-03-2017 SHXM_RS25510 91e8be5f28f19b2b38be083a9bf73f39 436 SUPERFAMILY SSF53822 42 395 5.18E-23 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS25510 91e8be5f28f19b2b38be083a9bf73f39 436 Pfam PF13458 Periplasmic binding protein 53 391 2.1E-26 T 17-03-2017 IPR028081 Leucine-binding protein domain SHXM_RS23325 af812f54e4a3995076585a5d06c5260b 435 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 226 417 2.2E-23 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS23325 af812f54e4a3995076585a5d06c5260b 435 SUPERFAMILY SSF52266 216 422 6.87E-44 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS23325 af812f54e4a3995076585a5d06c5260b 435 Gene3D G3DSA:3.40.50.1110 224 422 6.9E-34 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 Gene3D G3DSA:1.10.10.10 124 186 5.8E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 SUPERFAMILY SSF88946 31 102 9.42E-15 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 SUPERFAMILY SSF88659 112 186 5.05E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 Pfam PF04542 Sigma-70 region 2 37 101 2.3E-11 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 Gene3D G3DSA:1.10.1740.10 31 101 6.7E-15 T 17-03-2017 SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 28 187 5.0E-57 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 33 184 1.9E-22 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27125 133c8f6e30560223a1c1caefff0ce4f0 189 Pfam PF08281 Sigma-70, region 4 128 181 1.7E-12 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 Pfam PF00440 Bacterial regulatory proteins, tetR family 43 82 1.0E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 Gene3D G3DSA:1.10.357.10 81 221 2.4E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 ProSitePatterns PS01081 TetR-type HTH domain signature. 53 84 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 SUPERFAMILY SSF46689 30 92 2.74E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 54 1.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 62 85 1.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14715 599c4b29d70a7ac99b02bb1232b4cd07 274 Gene3D G3DSA:1.10.10.60 37 80 1.1E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35000 0dde5f6f744014d82538dfa7971ff48f 222 Gene3D G3DSA:2.70.50.50 37 221 1.5E-42 T 17-03-2017 SHXM_RS35000 0dde5f6f744014d82538dfa7971ff48f 222 SUPERFAMILY SSF81296 37 222 1.68E-33 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS35000 0dde5f6f744014d82538dfa7971ff48f 222 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 37 219 2.4E-33 T 17-03-2017 IPR004302 Chitin-binding protein, N-terminal SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 Gene3D G3DSA:2.60.40.1180 563 640 9.2E-12 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 Gene3D G3DSA:3.20.20.80 196 557 4.2E-70 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 SMART SM00642 196 554 2.5E-4 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 SUPERFAMILY SSF51445 196 559 4.37E-84 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 Pfam PF11896 Domain of unknown function (DUF3416) 3 190 2.1E-62 T 17-03-2017 IPR021828 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S GO:0004553 KEGG: 00500+2.4.99.16 SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 SUPERFAMILY SSF51011 564 640 1.22E-5 T 17-03-2017 SHXM_RS35710 28e7c228da48a7d285bb09c2d007cccd 664 Hamap MF_02124 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase [glgE]. 1 654 46.2 T 17-03-2017 IPR026585 Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase GO:0016757 KEGG: 00500+2.4.99.16 SHXM_RS48530 38fcf63c359bbd7fd17d5c31fa405ede 312 Pfam PF00294 pfkB family carbohydrate kinase 2 289 3.2E-34 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS48530 38fcf63c359bbd7fd17d5c31fa405ede 312 Gene3D G3DSA:3.40.1190.20 2 299 1.1E-57 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS48530 38fcf63c359bbd7fd17d5c31fa405ede 312 PRINTS PR00990 Ribokinase signature 31 50 1.8E-8 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS48530 38fcf63c359bbd7fd17d5c31fa405ede 312 PRINTS PR00990 Ribokinase signature 4 25 1.8E-8 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS48530 38fcf63c359bbd7fd17d5c31fa405ede 312 PRINTS PR00990 Ribokinase signature 211 222 1.8E-8 T 17-03-2017 IPR002139 Ribokinase/fructokinase GO:0004747|GO:0006014 SHXM_RS48530 38fcf63c359bbd7fd17d5c31fa405ede 312 SUPERFAMILY SSF53613 2 297 1.48E-48 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS18080 09dab749398615f5f05832edc0a16f7d 153 SUPERFAMILY SSF51126 48 145 2.1E-24 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS18080 09dab749398615f5f05832edc0a16f7d 153 Gene3D G3DSA:2.160.20.10 48 144 5.5E-20 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS18080 09dab749398615f5f05832edc0a16f7d 153 Pfam PF14592 Chondroitinase B 48 126 5.4E-6 T 17-03-2017 SHXM_RS46040 617f2240e9f82ff3ee5112990d15fb5d 393 ProSitePatterns PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 202 222 - T 17-03-2017 IPR020578 Aminotransferase class-V, pyridoxal-phosphate binding site SHXM_RS46040 617f2240e9f82ff3ee5112990d15fb5d 393 Gene3D G3DSA:3.90.1150.10 271 388 2.2E-25 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS46040 617f2240e9f82ff3ee5112990d15fb5d 393 Gene3D G3DSA:3.40.640.10 29 270 1.5E-60 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS46040 617f2240e9f82ff3ee5112990d15fb5d 393 SUPERFAMILY SSF53383 1 390 7.13E-88 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS46040 617f2240e9f82ff3ee5112990d15fb5d 393 Pfam PF00266 Aminotransferase class-V 18 380 2.8E-63 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 SUPERFAMILY SSF55961 103 249 6.32E-38 T 17-03-2017 SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 Pfam PF12840 Helix-turn-helix domain 2 62 1.8E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 53 68 4.7E-5 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 5 20 4.7E-5 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 38 53 4.7E-5 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 Gene3D G3DSA:3.30.530.20 94 252 1.3E-39 T 17-03-2017 IPR023393 START-like domain SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 SUPERFAMILY SSF46785 2 105 1.1E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 SMART SM00418 3 85 4.8E-16 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 Gene3D G3DSA:1.10.10.10 3 85 4.9E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03295 65e2742a2a4b912eae0fd95a884367fd 256 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 121 242 1.1E-22 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS12040 e71504fd554945b26b698d7033638833 371 Gene3D G3DSA:3.20.20.70 15 318 1.1E-23 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS12040 e71504fd554945b26b698d7033638833 371 SUPERFAMILY SSF102114 16 318 4.19E-26 T 17-03-2017 SHXM_RS44640 62a0297a63e222c058e2e396f039abb7 1432 Pfam PF10145 Phage-related minor tail protein 109 310 9.1E-25 T 17-03-2017 IPR010090 Phage tail tape measure protein SHXM_RS44640 62a0297a63e222c058e2e396f039abb7 1432 Gene3D G3DSA:1.10.530.10 941 1036 5.0E-7 T 17-03-2017 SHXM_RS44640 62a0297a63e222c058e2e396f039abb7 1432 Pfam PF01464 Transglycosylase SLT domain 968 1054 5.2E-8 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS44640 62a0297a63e222c058e2e396f039abb7 1432 SUPERFAMILY SSF53955 942 1052 1.13E-11 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS42100 6fe0aa2781c9bd5b9a5f0ea67f719b56 167 SMART SM00347 32 137 6.7E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42100 6fe0aa2781c9bd5b9a5f0ea67f719b56 167 SUPERFAMILY SSF46785 12 149 2.06E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42100 6fe0aa2781c9bd5b9a5f0ea67f719b56 167 Pfam PF01047 MarR family 57 101 2.1E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42100 6fe0aa2781c9bd5b9a5f0ea67f719b56 167 Gene3D G3DSA:1.10.10.10 12 131 1.7E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37715 6e9957b825bc5d732273eca71475a1f3 263 SUPERFAMILY SSF46894 202 261 4.42E-8 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS37715 6e9957b825bc5d732273eca71475a1f3 263 Gene3D G3DSA:1.10.10.10 205 260 1.1E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07210 a414eaa560ea8bdc22db6e4bd2a5e74a 417 SUPERFAMILY SSF53756 1 412 3.43E-80 T 17-03-2017 SHXM_RS07210 a414eaa560ea8bdc22db6e4bd2a5e74a 417 Pfam PF06722 Protein of unknown function (DUF1205) 204 299 1.1E-18 T 17-03-2017 IPR010610 Domain of unknown function DUF1205 SHXM_RS07210 a414eaa560ea8bdc22db6e4bd2a5e74a 417 Gene3D G3DSA:3.40.50.2000 241 394 6.1E-22 T 17-03-2017 SHXM_RS07210 a414eaa560ea8bdc22db6e4bd2a5e74a 417 TIGRFAM TIGR04516 glycosyl_450act: glycosyltransferase, activator-dependent family 1 415 3.2E-158 T 17-03-2017 IPR030953 Glycosyltransferase, activator-dependent family GO:0016757 SHXM_RS07210 a414eaa560ea8bdc22db6e4bd2a5e74a 417 Gene3D G3DSA:3.40.50.2000 1 240 3.1E-37 T 17-03-2017 SHXM_RS28945 022e9378bf0c9cdcd52a729b423e7804 261 Pfam PF13936 Helix-turn-helix domain 5 45 2.1E-12 T 17-03-2017 IPR025246 Transposase IS30-like HTH domain SHXM_RS28945 022e9378bf0c9cdcd52a729b423e7804 261 Pfam PF12802 MarR family 111 162 5.5E-8 T 17-03-2017 SHXM_RS28945 022e9378bf0c9cdcd52a729b423e7804 261 SUPERFAMILY SSF46785 107 219 7.52E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28945 022e9378bf0c9cdcd52a729b423e7804 261 Gene3D G3DSA:1.10.10.10 88 167 2.0E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20645 b8987406f87579c67121a4448e1ebc65 107 Pfam PF03091 CutA1 divalent ion tolerance protein 6 102 9.1E-37 T 17-03-2017 IPR004323 Divalent ion tolerance protein, CutA GO:0010038 SHXM_RS20645 b8987406f87579c67121a4448e1ebc65 107 SUPERFAMILY SSF54913 3 104 9.27E-37 T 17-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta SHXM_RS20645 b8987406f87579c67121a4448e1ebc65 107 Gene3D G3DSA:3.30.70.830 3 104 5.3E-40 T 17-03-2017 SHXM_RS43230 cd4214f74739783291460e442063e497 169 Gene3D G3DSA:3.10.129.10 2 148 1.4E-42 T 17-03-2017 IPR029069 HotDog domain SHXM_RS43230 cd4214f74739783291460e442063e497 169 SUPERFAMILY SSF54637 4 144 2.8E-24 T 17-03-2017 IPR029069 HotDog domain SHXM_RS43230 cd4214f74739783291460e442063e497 169 Pfam PF14539 Domain of unknown function (DUF4442) 7 143 2.1E-17 T 17-03-2017 IPR027961 Protein of unknown function DUF4442 SHXM_RS36440 36f72e26ca6c20ca2be1dcc3ffff86ee 369 Gene3D G3DSA:1.20.5.620 60 115 4.0E-5 T 17-03-2017 IPR028987 F-type ATP synthase subunit B-like, membrane domain SHXM_RS36440 36f72e26ca6c20ca2be1dcc3ffff86ee 369 SUPERFAMILY SSF81573 60 115 3.66E-5 T 17-03-2017 IPR028987 F-type ATP synthase subunit B-like, membrane domain SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 Pfam PF04542 Sigma-70 region 2 22 86 8.6E-8 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 SUPERFAMILY SSF88659 106 168 9.91E-17 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 Gene3D G3DSA:1.10.10.10 108 168 1.9E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 26 168 4.4E-22 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 SUPERFAMILY SSF88946 17 105 7.46E-13 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 16 171 4.6E-62 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 Pfam PF08281 Sigma-70, region 4 113 166 2.0E-18 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS27550 1ac620e27bcd8b2a8692e8b9f3a7bf9d 176 Gene3D G3DSA:1.10.1740.10 16 86 1.4E-12 T 17-03-2017 SHXM_RS47805 a33b458320267a8f1021896ccb62b5b3 288 SUPERFAMILY SSF51735 4 244 1.01E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47805 a33b458320267a8f1021896ccb62b5b3 288 Gene3D G3DSA:3.40.50.720 4 213 1.8E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47805 a33b458320267a8f1021896ccb62b5b3 288 Pfam PF13460 NAD(P)H-binding 8 177 6.1E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 PIRSF PIRSF000171 1 578 2.8E-50 T 17-03-2017 IPR030664 Succinate dehydrogenase/fumarate reductase, alpha/adenylylsulphate reductase subunit Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 ProSitePatterns PS00504 Fumarate reductase / succinate dehydrogenase FAD-binding site. 40 49 - T 17-03-2017 IPR003952 Fumarate reductase/succinate dehydrogenase, FAD-binding site GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Gene3D G3DSA:4.10.80.40 543 580 3.1E-18 T 17-03-2017 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 SUPERFAMILY SSF56425 236 355 3.44E-43 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Gene3D G3DSA:1.20.58.100 426 542 1.0E-42 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Pfam PF00890 FAD binding domain 7 400 2.2E-115 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 SUPERFAMILY SSF46977 446 584 1.2E-50 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 TIGRFAM TIGR01812 sdhA_frdA_Gneg: succinate dehydrogenase or fumarate reductase, flavoprotein subunit 7 584 6.1E-248 T 17-03-2017 IPR014006 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit GO:0016627|GO:0022900|GO:0050660|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 TIGRFAM TIGR01816 sdhA_forward: succinate dehydrogenase, flavoprotein subunit 4 584 2.2E-277 T 17-03-2017 IPR011281 Succinate dehydrogenase, flavoprotein subunit GO:0006099|GO:0016627|GO:0050660|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 363 385 4.4E-5 T 17-03-2017 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 4.4E-5 T 17-03-2017 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Gene3D G3DSA:3.50.50.60 350 419 9.8E-116 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Gene3D G3DSA:3.50.50.60 2 242 9.8E-116 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 SUPERFAMILY SSF51905 2 259 3.26E-72 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 SUPERFAMILY SSF51905 358 429 3.26E-72 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Gene3D G3DSA:3.90.700.10 243 349 2.5E-41 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25115 382f1169131fc58ae975ee9c19a80403 584 Pfam PF02910 Fumarate reductase flavoprotein C-term 454 584 2.6E-46 T 17-03-2017 IPR015939 Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS19590 bd7a2e0ce93cb3a1a1f2a41ab916b8ef 400 SUPERFAMILY SSF81606 189 395 6.02E-10 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS19590 bd7a2e0ce93cb3a1a1f2a41ab916b8ef 400 SMART SM00331 175 395 2.6E-17 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS19590 bd7a2e0ce93cb3a1a1f2a41ab916b8ef 400 Gene3D G3DSA:3.60.40.10 317 395 4.5E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS19590 bd7a2e0ce93cb3a1a1f2a41ab916b8ef 400 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 202 395 3.8E-40 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 Pfam PF01022 Bacterial regulatory protein, arsR family 35 80 2.4E-11 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 SMART SM00418 28 106 1.0E-22 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 Gene3D G3DSA:1.10.10.10 16 110 2.4E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 SUPERFAMILY SSF46785 18 104 1.93E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 77 92 4.9E-13 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 30 45 4.9E-13 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS05940 2b18ab23f24447674806394a6e08e377 119 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 62 77 4.9E-13 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS36700 d334339627984f5d0113a6ac9cbb3d86 365 Gene3D G3DSA:3.40.50.450 146 204 1.1E-38 T 17-03-2017 SHXM_RS36700 d334339627984f5d0113a6ac9cbb3d86 365 Gene3D G3DSA:3.40.50.450 238 356 1.1E-38 T 17-03-2017 SHXM_RS36700 d334339627984f5d0113a6ac9cbb3d86 365 SUPERFAMILY SSF102405 241 360 2.44E-27 T 17-03-2017 SHXM_RS36700 d334339627984f5d0113a6ac9cbb3d86 365 SUPERFAMILY SSF102405 144 200 2.44E-27 T 17-03-2017 SHXM_RS36700 d334339627984f5d0113a6ac9cbb3d86 365 Pfam PF03641 Possible lysine decarboxylase 241 360 4.2E-6 T 17-03-2017 IPR031100 LOG family SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 SUPERFAMILY SSF109709 181 290 1.39E-32 T 17-03-2017 SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 SMART SM00470 99 189 1.0E-34 T 17-03-2017 IPR003115 ParB/Sulfiredoxin SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 TIGRFAM TIGR00180 parB_part: ParB/RepB/Spo0J family partition protein 97 274 2.9E-60 T 17-03-2017 IPR004437 ParB/RepB/Spo0J partition protein family GO:0003677 SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 SUPERFAMILY SSF110849 92 192 1.02E-28 T 17-03-2017 IPR003115 ParB/Sulfiredoxin SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 Gene3D G3DSA:1.10.10.10 204 236 7.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 Gene3D G3DSA:3.90.1530.10 95 195 2.8E-39 T 17-03-2017 SHXM_RS28080 ae884103aa3e79f86bae810a8b4d65a4 380 Pfam PF02195 ParB-like nuclease domain 100 188 2.7E-25 T 17-03-2017 IPR003115 ParB/Sulfiredoxin SHXM_RS10290 5db726046aff2b5f79aa556b37b2f482 359 Gene3D G3DSA:3.30.420.10 175 325 8.8E-13 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10290 5db726046aff2b5f79aa556b37b2f482 359 SUPERFAMILY SSF53098 176 326 4.4E-16 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10290 5db726046aff2b5f79aa556b37b2f482 359 SUPERFAMILY SSF46689 75 153 8.78E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10290 5db726046aff2b5f79aa556b37b2f482 359 Pfam PF13683 Integrase core domain 266 325 7.8E-13 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 SMART SM00271 3 60 5.8E-31 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Gene3D G3DSA:2.10.230.10 136 208 1.6E-19 T 17-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 SUPERFAMILY SSF57938 129 209 4.19E-18 T 17-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Pfam PF00226 DnaJ domain 4 65 4.1E-26 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 TIGRFAM TIGR02349 DnaJ_bact: chaperone protein DnaJ 4 348 5.2E-118 T 17-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Hamap MF_01152 Chaperone protein DnaJ [dnaJ]. 1 373 37.749 T 17-03-2017 IPR012724 Chaperone DnaJ GO:0005524|GO:0006457|GO:0009408|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 ProSitePatterns PS00636 Nt-dnaJ domain signature. 45 64 - T 17-03-2017 IPR018253 DnaJ domain, conserved site SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 PRINTS PR00625 DnaJ domain signature 40 60 6.2E-24 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 PRINTS PR00625 DnaJ domain signature 60 79 6.2E-24 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 PRINTS PR00625 DnaJ domain signature 6 24 6.2E-24 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 PRINTS PR00625 DnaJ domain signature 24 39 6.2E-24 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 SUPERFAMILY SSF49493 257 343 6.8E-21 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Pfam PF01556 DnaJ C terminal domain 117 332 4.4E-38 T 17-03-2017 IPR002939 Chaperone DnaJ, C-terminal SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 SUPERFAMILY SSF46565 3 98 5.89E-33 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Gene3D G3DSA:2.60.260.20 95 135 2.7E-21 T 17-03-2017 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Gene3D G3DSA:2.60.260.20 209 252 2.7E-21 T 17-03-2017 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 SUPERFAMILY SSF49493 212 260 4.06E-20 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 SUPERFAMILY SSF49493 108 147 4.06E-20 T 17-03-2017 IPR008971 HSP40/DnaJ peptide-binding GO:0006457|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Pfam PF00684 DnaJ central domain 142 206 1.6E-12 T 17-03-2017 IPR001305 Heat shock protein DnaJ, cysteine-rich domain GO:0031072|GO:0051082 SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Gene3D G3DSA:1.10.287.110 3 94 4.0E-33 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS21290 1e7492f0f599a6939c90d211991b0f1b 377 Gene3D G3DSA:2.60.260.20 255 333 2.4E-20 T 17-03-2017 SHXM_RS00255 d72ad7298a7c829e68a532c12488f678 311 SUPERFAMILY SSF47413 30 84 9.57E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00255 d72ad7298a7c829e68a532c12488f678 311 Pfam PF13560 Helix-turn-helix domain 31 92 1.1E-14 T 17-03-2017 SHXM_RS00255 d72ad7298a7c829e68a532c12488f678 311 SMART SM00530 34 89 3.1E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS00255 d72ad7298a7c829e68a532c12488f678 311 Gene3D G3DSA:1.10.260.40 30 84 1.7E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS32695 e65948adf7b28eb6de50bd892ccdf64d 611 SUPERFAMILY SSF50998 239 551 3.18E-9 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS21880 257027cdb364b048bf7500d7ec9eee4e 741 SUPERFAMILY SSF51445 650 728 1.53E-136 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21880 257027cdb364b048bf7500d7ec9eee4e 741 SUPERFAMILY SSF51445 186 621 1.53E-136 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS21880 257027cdb364b048bf7500d7ec9eee4e 741 Gene3D G3DSA:3.20.20.80 186 711 2.1E-160 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS21880 257027cdb364b048bf7500d7ec9eee4e 741 TIGRFAM TIGR00217 malQ: 4-alpha-glucanotransferase 152 707 1.8E-86 T 17-03-2017 IPR003385 Glycoside hydrolase, family 77 GO:0004134|GO:0005975 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SHXM_RS21880 257027cdb364b048bf7500d7ec9eee4e 741 Pfam PF02446 4-alpha-glucanotransferase 192 704 1.4E-112 T 17-03-2017 IPR003385 Glycoside hydrolase, family 77 GO:0004134|GO:0005975 KEGG: 00500+2.4.1.25|MetaCyc: PWY-5941|MetaCyc: PWY-6724|MetaCyc: PWY-6737|MetaCyc: PWY-7238 SHXM_RS39495 564b7cd95b07d0b577eebe01e6bf0093 290 Gene3D G3DSA:1.10.260.40 3 81 1.5E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39495 564b7cd95b07d0b577eebe01e6bf0093 290 SUPERFAMILY SSF47413 34 81 1.38E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39495 564b7cd95b07d0b577eebe01e6bf0093 290 SMART SM00530 13 85 4.5E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS39495 564b7cd95b07d0b577eebe01e6bf0093 290 Pfam PF13560 Helix-turn-helix domain 9 86 1.0E-16 T 17-03-2017 SHXM_RS47970 6362a6996ba64beb3d94c5c59a112abb 144 Gene3D G3DSA:1.10.443.10 60 138 1.1E-6 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 SMART SM00448 3 120 7.5E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 SMART SM00421 158 215 5.5E-26 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 161 175 4.7E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 191 203 4.7E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 175 191 4.7E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 Pfam PF00196 Bacterial regulatory proteins, luxR family 161 215 4.1E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 ProSitePatterns PS00622 LuxR-type HTH domain signature. 175 202 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 Gene3D G3DSA:1.10.10.10 129 223 3.5E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 SUPERFAMILY SSF52172 3 192 3.58E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 Gene3D G3DSA:3.40.50.2300 1 128 2.3E-38 T 17-03-2017 SHXM_RS20270 cb5fe22137bf49802874bd07607fe582 225 Pfam PF00072 Response regulator receiver domain 5 121 8.2E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05710 8d1174eab8e9a68e32ad4f6f3ffbbe19 320 SUPERFAMILY SSF53474 29 314 1.19E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS05710 8d1174eab8e9a68e32ad4f6f3ffbbe19 320 Gene3D G3DSA:3.40.50.1820 3 317 2.3E-63 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS05710 8d1174eab8e9a68e32ad4f6f3ffbbe19 320 Pfam PF07859 alpha/beta hydrolase fold 90 296 7.5E-47 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS34775 1bcdce53028a865243aac247ed6d09d7 320 SUPERFAMILY SSF51735 129 294 1.11E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34775 1bcdce53028a865243aac247ed6d09d7 320 Gene3D G3DSA:3.90.180.10 8 159 5.3E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS34775 1bcdce53028a865243aac247ed6d09d7 320 Pfam PF13602 Zinc-binding dehydrogenase 210 318 3.1E-16 T 17-03-2017 SHXM_RS34775 1bcdce53028a865243aac247ed6d09d7 320 SMART SM00829 13 318 2.6E-11 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS34775 1bcdce53028a865243aac247ed6d09d7 320 Gene3D G3DSA:3.40.50.720 160 267 2.9E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34775 1bcdce53028a865243aac247ed6d09d7 320 SUPERFAMILY SSF50129 6 154 1.79E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 Pfam PF07719 Tetratricopeptide repeat 250 278 1.3E-5 T 17-03-2017 IPR013105 Tetratricopeptide repeat 2 SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 Pfam PF13424 Tetratricopeptide repeat 169 231 3.2E-7 T 17-03-2017 SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 SMART SM00028 167 200 20.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 SMART SM00028 248 281 0.042 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 Gene3D G3DSA:1.25.40.10 129 280 6.3E-17 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 Gene3D G3DSA:1.25.40.10 33 123 2.2E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04895 c1948d068062d6856cdc3312ba3d9c7f 348 SUPERFAMILY SSF48452 134 302 2.77E-18 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22665 7038d103ed047bf545e9a7234938f74b 202 SMART SM00479 4 178 5.1E-25 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS22665 7038d103ed047bf545e9a7234938f74b 202 Gene3D G3DSA:3.30.420.10 1 177 2.1E-66 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS22665 7038d103ed047bf545e9a7234938f74b 202 Hamap MF_00045 Oligoribonuclease [orn]. 1 179 37.538 T 17-03-2017 IPR022894 Oligoribonuclease GO:0016788 SHXM_RS22665 7038d103ed047bf545e9a7234938f74b 202 Pfam PF00929 Exonuclease 6 168 3.2E-25 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS22665 7038d103ed047bf545e9a7234938f74b 202 SUPERFAMILY SSF53098 3 177 3.8E-41 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 SUPERFAMILY SSF55979 126 249 2.26E-17 T 17-03-2017 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 SUPERFAMILY SSF55979 2 119 4.45E-24 T 17-03-2017 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 Gene3D G3DSA:3.10.150.10 2 120 8.1E-32 T 17-03-2017 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 Gene3D G3DSA:3.10.150.10 126 250 3.0E-28 T 17-03-2017 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 SUPERFAMILY SSF55979 249 374 2.08E-29 T 17-03-2017 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 Gene3D G3DSA:3.10.150.10 252 374 6.6E-38 T 17-03-2017 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 SMART SM00480 17 370 5.5E-138 T 17-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 TIGRFAM TIGR00663 dnan: DNA polymerase III, beta subunit 1 374 8.9E-89 T 17-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 Pfam PF02768 DNA polymerase III beta subunit, C-terminal domain 248 373 1.3E-35 T 17-03-2017 IPR022635 DNA polymerase III, beta chain, C-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 PIRSF PIRSF000804 1 375 4.0E-93 T 17-03-2017 IPR001001 DNA polymerase III, beta chain GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 Pfam PF02767 DNA polymerase III beta subunit, central domain 127 246 1.5E-31 T 17-03-2017 IPR022637 DNA polymerase III, beta chain, central GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS28130 81ce0d0e0635ed84e9d0375369bf26e6 376 Pfam PF00712 DNA polymerase III beta subunit, N-terminal domain 2 118 2.6E-37 T 17-03-2017 IPR022634 DNA polymerase III, beta chain, N-terminal GO:0003677|GO:0003887|GO:0006260|GO:0008408|GO:0009360 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 SUPERFAMILY SSF51182 68 174 3.82E-15 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 Gene3D G3DSA:2.60.120.10 87 175 3.1E-14 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 Pfam PF01381 Helix-turn-helix 16 70 4.9E-16 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 Gene3D G3DSA:1.10.260.40 13 80 1.6E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 SUPERFAMILY SSF47413 11 74 5.91E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 Pfam PF07883 Cupin domain 117 172 1.8E-8 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS50675 dcace14b705624082301bfb850aab59c 204 SMART SM00530 15 70 9.6E-18 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS02040 eadf01b17d1397e8cdbf6adeae66e894 524 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 94 413 2.2E-68 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS02040 eadf01b17d1397e8cdbf6adeae66e894 524 Gene3D G3DSA:3.90.76.10 60 215 2.8E-37 T 17-03-2017 SHXM_RS02040 eadf01b17d1397e8cdbf6adeae66e894 524 SUPERFAMILY SSF53850 46 505 3.62E-105 T 17-03-2017 SHXM_RS02040 eadf01b17d1397e8cdbf6adeae66e894 524 Gene3D G3DSA:3.10.105.10 287 495 6.4E-36 T 17-03-2017 SHXM_RS02040 eadf01b17d1397e8cdbf6adeae66e894 524 PIRSF PIRSF002741 17 517 1.2E-85 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS00825 cd044a655f0f43d1b24d0b58972091c2 220 Gene3D G3DSA:3.40.50.980 75 162 1.1E-16 T 17-03-2017 SHXM_RS00825 cd044a655f0f43d1b24d0b58972091c2 220 SUPERFAMILY SSF56801 59 178 1.96E-17 T 17-03-2017 SHXM_RS00825 cd044a655f0f43d1b24d0b58972091c2 220 Pfam PF00501 AMP-binding enzyme 76 185 2.1E-14 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 Gene3D G3DSA:1.20.1270.50 522 612 2.8E-19 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 Gene3D G3DSA:3.20.110.10 208 521 5.7E-83 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 Pfam PF09261 Alpha mannosidase middle domain 519 597 6.0E-22 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 SUPERFAMILY SSF74650 617 1033 8.79E-63 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 254 511 2.6E-82 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 SMART SM00872 519 597 1.5E-28 T 17-03-2017 IPR015341 Glycoside hydrolase family 38, central domain GO:0004553|GO:0008270 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 620 1030 3.3E-61 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 SUPERFAMILY SSF88713 248 517 7.56E-74 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS42400 0ff86b42639159ce65650c178df5612b 1036 SUPERFAMILY SSF88688 518 611 6.87E-22 T 17-03-2017 IPR028995 Glycoside hydrolase families 57/38, central domain SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 SUPERFAMILY SSF52172 16 196 2.85E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 Pfam PF00072 Response regulator receiver domain 20 129 6.7E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 SMART SM00448 18 129 1.5E-38 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 Pfam PF00486 Transcriptional regulatory protein, C terminal 167 239 7.2E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 Gene3D G3DSA:3.40.50.2300 12 138 1.7E-39 T 17-03-2017 SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 Gene3D G3DSA:1.10.10.10 143 241 1.2E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43045 d3579fd8998ca323cf09c4bc8c400fbd 244 SMART SM00862 165 239 1.1E-26 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS28975 ea40669c26686984879a5a590081c67f 384 PIRSF PIRSF015921 42 384 6.8E-74 T 17-03-2017 IPR012171 Fatty acid desaturase GO:0006629|GO:0016021|GO:0016491 SHXM_RS28975 ea40669c26686984879a5a590081c67f 384 Pfam PF00487 Fatty acid desaturase 97 357 3.5E-37 T 17-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 SHXM_RS42975 fce0ee35bee52b19fc8d80ff42b3b33d 311 Pfam PF05141 Pyoverdine/dityrosine biosynthesis protein 47 294 1.2E-74 T 17-03-2017 IPR007817 Pyoverdine biosynthesis SHXM_RS42975 fce0ee35bee52b19fc8d80ff42b3b33d 311 PIRSF PIRSF037196 3 310 1.6E-96 T 17-03-2017 IPR017133 Pyoverdine chromophore biosynthesis protein PvcA SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Gene3D G3DSA:3.20.20.300 11 299 9.2E-95 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 SUPERFAMILY SSF52279 562 718 1.31E-49 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 SUPERFAMILY SSF52279 324 402 1.31E-49 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 PRINTS PR00133 Glycosyl hydrolase family 3 signature 72 91 1.9E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 PRINTS PR00133 Glycosyl hydrolase family 3 signature 219 237 1.9E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 PRINTS PR00133 Glycosyl hydrolase family 3 signature 118 134 1.9E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 PRINTS PR00133 Glycosyl hydrolase family 3 signature 43 59 1.9E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 PRINTS PR00133 Glycosyl hydrolase family 3 signature 149 165 1.9E-33 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Pfam PF01915 Glycosyl hydrolase family 3 C-terminal domain 325 694 8.6E-53 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 SUPERFAMILY SSF51445 10 323 8.53E-90 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Pfam PF07691 PA14 domain 454 525 1.9E-4 T 17-03-2017 IPR011658 PA14 domain SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 ProSitePatterns PS00775 Glycosyl hydrolases family 3 active site. 219 236 - T 17-03-2017 IPR019800 Glycoside hydrolase, family 3, active site GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Pfam PF00933 Glycosyl hydrolase family 3 N terminal domain 63 287 8.2E-54 T 17-03-2017 IPR001764 Glycoside hydrolase, family 3, N-terminal GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Gene3D G3DSA:3.40.50.1700 313 402 5.7E-68 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Gene3D G3DSA:3.40.50.1700 562 717 5.7E-68 T 17-03-2017 IPR002772 Glycoside hydrolase family 3 C-terminal domain GO:0004553|GO:0005975 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 SUPERFAMILY SSF56988 459 607 1.24E-5 T 17-03-2017 SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 Pfam PF14310 Fibronectin type III-like domain 752 830 5.8E-17 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS20340 bef3b17652c094711cdd4d5e7958e2b8 846 SMART SM01217 752 831 3.5E-19 T 17-03-2017 IPR026891 Fibronectin type III-like domain SHXM_RS28750 2ad39f8235fd1d9e81f892aa5574429b 278 PIRSF PIRSF004846 12 278 3.4E-66 T 17-03-2017 IPR005950 Molybdenum ABC transporter, periplasmic binding protein GO:0015412|GO:0015689|GO:0030288 SHXM_RS28750 2ad39f8235fd1d9e81f892aa5574429b 278 Pfam PF13531 Bacterial extracellular solute-binding protein 58 275 3.7E-41 T 17-03-2017 SHXM_RS28750 2ad39f8235fd1d9e81f892aa5574429b 278 TIGRFAM TIGR01256 modA: molybdate ABC transporter, periplasmic molybdate-binding protein 63 272 2.2E-38 T 17-03-2017 IPR005950 Molybdenum ABC transporter, periplasmic binding protein GO:0015412|GO:0015689|GO:0030288 SHXM_RS28750 2ad39f8235fd1d9e81f892aa5574429b 278 Gene3D G3DSA:3.40.190.10 180 268 1.1E-5 T 17-03-2017 SHXM_RS28750 2ad39f8235fd1d9e81f892aa5574429b 278 SUPERFAMILY SSF53850 57 278 7.06E-52 T 17-03-2017 SHXM_RS28750 2ad39f8235fd1d9e81f892aa5574429b 278 Gene3D G3DSA:3.40.190.10 54 179 7.5E-37 T 17-03-2017 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 SUPERFAMILY SSF100950 78 238 1.4E-26 T 17-03-2017 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 SUPERFAMILY SSF46785 8 62 2.08E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 SMART SM01134 75 236 1.3E-55 T 17-03-2017 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 Pfam PF00455 DeoR C terminal sensor domain 79 234 4.6E-41 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 27 41 4.6E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 41 59 4.6E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 Gene3D G3DSA:3.40.50.1360 79 219 4.8E-12 T 17-03-2017 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 Gene3D G3DSA:1.10.10.10 8 52 5.2E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 SMART SM00420 9 61 2.3E-11 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS08250 4e35ca042c8a713803689efa9528d7fc 258 Pfam PF08220 DeoR-like helix-turn-helix domain 9 60 1.1E-13 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS17165 f5829221586fc1e2be74802118ff88b6 345 SUPERFAMILY SSF56784 20 273 8.72E-53 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17165 f5829221586fc1e2be74802118ff88b6 345 Pfam PF13242 HAD-hyrolase-like 200 271 2.6E-15 T 17-03-2017 SHXM_RS17165 f5829221586fc1e2be74802118ff88b6 345 Pfam PF13344 Haloacid dehalogenase-like hydrolase 24 123 8.3E-25 T 17-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA SHXM_RS17165 f5829221586fc1e2be74802118ff88b6 345 Gene3D G3DSA:3.40.50.1000 17 92 8.4E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17165 f5829221586fc1e2be74802118ff88b6 345 Gene3D G3DSA:3.40.50.1000 199 274 8.4E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17165 f5829221586fc1e2be74802118ff88b6 345 Gene3D G3DSA:3.40.50.10410 93 198 6.7E-24 T 17-03-2017 IPR023215 Nitrophenylphosphatase-like domain SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.50.50.60 507 552 1.4E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.50.50.60 324 367 1.4E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.90.660.10 87 159 2.9E-28 T 17-03-2017 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.90.660.10 371 473 2.9E-28 T 17-03-2017 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.50.50.60 71 86 1.6E-10 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.50.50.60 282 323 1.6E-10 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 SUPERFAMILY SSF51905 56 382 8.51E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 SUPERFAMILY SSF51905 504 544 8.51E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 SUPERFAMILY SSF54373 367 482 2.62E-27 T 17-03-2017 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Pfam PF01593 Flavin containing amine oxidoreductase 64 538 5.3E-47 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.50.50.60 168 195 1.3E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12230 f7f7959f3b2fb80258b717e1128b06c1 569 Gene3D G3DSA:3.50.50.60 37 70 1.3E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47410 d38f134486276aeb7137ea78919d54e7 126 Gene3D G3DSA:1.10.10.10 12 124 2.2E-45 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47410 d38f134486276aeb7137ea78919d54e7 126 Pfam PF01638 HxlR-like helix-turn-helix 26 114 1.2E-26 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS47410 d38f134486276aeb7137ea78919d54e7 126 SUPERFAMILY SSF46785 15 122 2.89E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23305 ed6ba12ca5b563afa36ce5529b0349f8 220 TIGRFAM TIGR03592 yidC_oxa1_cterm: membrane protein insertase, YidC/Oxa1 family 28 218 3.6E-31 T 17-03-2017 IPR028055 Membrane insertase YidC/Oxa1, C-terminal SHXM_RS23305 ed6ba12ca5b563afa36ce5529b0349f8 220 Pfam PF02096 60Kd inner membrane protein 29 218 7.9E-28 T 17-03-2017 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SHXM_RS21740 6a3461d233ef3bd2b1b7bbe3f02ae6ac 272 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS21740 6a3461d233ef3bd2b1b7bbe3f02ae6ac 272 SUPERFAMILY SSF52540 21 246 5.44E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21740 6a3461d233ef3bd2b1b7bbe3f02ae6ac 272 SMART SM00382 49 235 1.1E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS21740 6a3461d233ef3bd2b1b7bbe3f02ae6ac 272 Pfam PF00005 ABC transporter 40 186 1.0E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS21740 6a3461d233ef3bd2b1b7bbe3f02ae6ac 272 Gene3D G3DSA:3.40.50.300 20 247 3.5E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 Gene3D G3DSA:3.50.50.60 122 325 3.4E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 SUPERFAMILY SSF55424 334 455 2.06E-31 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 Gene3D G3DSA:3.50.50.60 4 121 1.9E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 160 178 2.0E-18 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 2.0E-18 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 245 261 2.0E-18 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 113 131 2.0E-18 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 318 2.9E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 SUPERFAMILY SSF51905 5 205 1.71E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 341 442 2.3E-19 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 160 185 1.7E-16 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 288 295 1.7E-16 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 246 260 1.7E-16 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 1.7E-16 T 17-03-2017 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 Gene3D G3DSA:3.30.390.30 346 455 1.1E-36 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS38260 f607a2196b09d931fb4646cbed7671ab 465 SUPERFAMILY SSF51905 160 329 3.55E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS10120 680552a6d210990f6c53d1492171858b 229 SMART SM00858 64 125 8.0E-5 T 17-03-2017 IPR013974 SAF domain Reactome: R-HSA-4085001 SHXM_RS10120 680552a6d210990f6c53d1492171858b 229 Pfam PF08666 SAF domain 66 119 9.4E-6 T 17-03-2017 IPR013974 SAF domain Reactome: R-HSA-4085001 SHXM_RS45395 998386b063e46ea8b01a14a83cad6f2d 344 SUPERFAMILY SSF52151 28 154 8.37E-32 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45395 998386b063e46ea8b01a14a83cad6f2d 344 SUPERFAMILY SSF52151 225 324 8.37E-32 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS45395 998386b063e46ea8b01a14a83cad6f2d 344 Gene3D G3DSA:3.40.366.10 223 311 2.8E-27 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS45395 998386b063e46ea8b01a14a83cad6f2d 344 Gene3D G3DSA:3.40.366.10 22 148 2.8E-27 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 Pfam PF00072 Response regulator receiver domain 4 115 9.3E-22 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 ProSitePatterns PS00622 LuxR-type HTH domain signature. 154 181 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 SMART SM00448 2 115 2.6E-21 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 SMART SM00421 137 194 2.0E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 Gene3D G3DSA:1.10.10.10 145 200 2.6E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 Gene3D G3DSA:3.40.50.2300 1 144 4.7E-31 T 17-03-2017 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 SUPERFAMILY SSF46894 128 200 4.76E-19 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 SUPERFAMILY SSF52172 1 129 4.98E-29 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 140 154 7.7E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 154 170 7.7E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 182 7.7E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS14965 4fba6ad7a89aef8d0d09c265159f8b7d 200 Pfam PF00196 Bacterial regulatory proteins, luxR family 139 194 2.1E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 SUPERFAMILY SSF51735 1130 1329 1.71E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 SUPERFAMILY SSF51735 990 1092 1.71E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 Gene3D G3DSA:3.40.50.720 1403 1428 5.7E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 Gene3D G3DSA:3.40.50.720 1143 1227 5.7E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 Gene3D G3DSA:3.40.50.720 987 1098 5.7E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 SUPERFAMILY SSF53223 799 985 2.78E-22 T 17-03-2017 SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 Pfam PF05088 Bacterial NAD-glutamate dehydrogenase 83 1648 0.0 T 17-03-2017 IPR028971 NAD-glutamate dehydrogenase GO:0004352|GO:0019551 KEGG: 00220+1.4.1.2|KEGG: 00250+1.4.1.2|KEGG: 00430+1.4.1.2|KEGG: 00910+1.4.1.2|MetaCyc: PWY-5022|MetaCyc: PWY-6728|MetaCyc: PWY-7126 SHXM_RS24050 ce099d47186f82d69e3eb22d2a38857a 1655 PIRSF PIRSF036761 2 1655 0.0 T 17-03-2017 IPR007780 NAD-glutamate dehydrogenase, bacteria GO:0004352|GO:0019551 KEGG: 00220+1.4.1.2|KEGG: 00250+1.4.1.2|KEGG: 00430+1.4.1.2|KEGG: 00910+1.4.1.2|MetaCyc: PWY-5022|MetaCyc: PWY-6728|MetaCyc: PWY-7126 SHXM_RS14990 754ceb0112a9752f11ff27db8bcd9f42 163 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 41 89 2.1E-20 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS14990 754ceb0112a9752f11ff27db8bcd9f42 163 SUPERFAMILY SSF69118 10 157 5.95E-38 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS14990 754ceb0112a9752f11ff27db8bcd9f42 163 Gene3D G3DSA:1.20.1290.10 16 158 3.4E-42 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS14990 754ceb0112a9752f11ff27db8bcd9f42 163 Pfam PF02627 Carboxymuconolactone decarboxylase family 20 106 7.4E-23 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 Pfam PF04851 Type III restriction enzyme, res subunit 27 178 1.3E-13 T 17-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 SUPERFAMILY SSF52540 267 390 6.88E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 SUPERFAMILY SSF52540 140 212 6.88E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 Gene3D G3DSA:3.40.50.300 289 418 1.0E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 SUPERFAMILY SSF52540 22 182 4.44E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 SMART SM00487 24 200 1.4E-17 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS23575 04071359b7970ccd612f595ab2692496 598 Gene3D G3DSA:3.40.50.300 26 181 4.8E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21895 cc14b05b3fb2b2df6924f087c57f2e1f 178 Pfam PF14279 HNH endonuclease 83 128 3.6E-13 T 17-03-2017 IPR029471 HNH endonuclease 5 SHXM_RS21895 cc14b05b3fb2b2df6924f087c57f2e1f 178 SMART SM00507 70 119 2.2E-14 T 17-03-2017 IPR003615 HNH nuclease SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 Gene3D G3DSA:1.20.1560.10 49 407 5.4E-89 T 17-03-2017 SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 SMART SM00382 445 631 8.3E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 SUPERFAMILY SSF52540 413 656 9.78E-90 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 SUPERFAMILY SSF90123 49 88 1.2E-85 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 SUPERFAMILY SSF90123 128 407 1.2E-85 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 Gene3D G3DSA:3.40.50.300 420 649 1.9E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 Pfam PF00005 ABC transporter 437 585 2.2E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 ProSitePatterns PS00211 ABC transporters family signature. 557 571 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS30120 2dc4094215ca516b372a1537f2f652a7 664 Pfam PF00664 ABC transporter transmembrane region 80 374 5.6E-61 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS14630 b17eff810d595ea27ad4cc5959ed7b9f 127 SMART SM00116 81 126 4.0E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS14630 b17eff810d595ea27ad4cc5959ed7b9f 127 SMART SM00116 16 63 1.5E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS14630 b17eff810d595ea27ad4cc5959ed7b9f 127 SUPERFAMILY SSF54631 7 124 5.18E-33 T 17-03-2017 SHXM_RS14630 b17eff810d595ea27ad4cc5959ed7b9f 127 Pfam PF00571 CBS domain 76 123 1.1E-13 T 17-03-2017 IPR000644 CBS domain SHXM_RS14630 b17eff810d595ea27ad4cc5959ed7b9f 127 Pfam PF00571 CBS domain 9 59 2.8E-13 T 17-03-2017 IPR000644 CBS domain SHXM_RS14630 b17eff810d595ea27ad4cc5959ed7b9f 127 Gene3D G3DSA:3.10.580.10 7 123 1.3E-34 T 17-03-2017 SHXM_RS46670 7edbb8662771bcf7235d395e84a38c19 205 Gene3D G3DSA:3.40.140.10 12 64 1.0E-7 T 17-03-2017 SHXM_RS46670 7edbb8662771bcf7235d395e84a38c19 205 Gene3D G3DSA:3.40.140.10 97 125 1.0E-7 T 17-03-2017 SHXM_RS46670 7edbb8662771bcf7235d395e84a38c19 205 SUPERFAMILY SSF102712 97 168 1.96E-7 T 17-03-2017 SHXM_RS46670 7edbb8662771bcf7235d395e84a38c19 205 SUPERFAMILY SSF102712 12 64 1.96E-7 T 17-03-2017 SHXM_RS08890 1424524b21e6a691ce89eb0aaf9b04e7 331 SMART SM00418 258 329 3.8E-5 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS08890 1424524b21e6a691ce89eb0aaf9b04e7 331 Gene3D G3DSA:1.10.10.10 262 329 1.6E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08890 1424524b21e6a691ce89eb0aaf9b04e7 331 Pfam PF12840 Helix-turn-helix domain 266 315 4.3E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08890 1424524b21e6a691ce89eb0aaf9b04e7 331 SUPERFAMILY SSF46785 263 329 2.04E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41730 400c6b2473c17c3efad366e5909fc84e 307 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 74 2.8E-9 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS41730 400c6b2473c17c3efad366e5909fc84e 307 Gene3D G3DSA:3.40.50.720 1 288 1.4E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41730 400c6b2473c17c3efad366e5909fc84e 307 SUPERFAMILY SSF51735 1 288 4.25E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42875 c1f0b47f15213aaa6ef7d6073e951eb5 156 SUPERFAMILY SSF54427 7 151 2.38E-36 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS42875 c1f0b47f15213aaa6ef7d6073e951eb5 156 Pfam PF13577 SnoaL-like domain 16 137 1.5E-27 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS42875 c1f0b47f15213aaa6ef7d6073e951eb5 156 Gene3D G3DSA:3.10.450.50 5 151 7.1E-37 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS48095 df621970ebcfcf9fe67049fd544b471b 345 Gene3D G3DSA:1.10.1530.10 13 77 2.2E-20 T 17-03-2017 SHXM_RS48095 df621970ebcfcf9fe67049fd544b471b 345 Gene3D G3DSA:3.30.1370.60 78 261 1.6E-53 T 17-03-2017 SHXM_RS48095 df621970ebcfcf9fe67049fd544b471b 345 SUPERFAMILY SSF89733 12 331 1.83E-86 T 17-03-2017 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS48095 df621970ebcfcf9fe67049fd544b471b 345 Pfam PF02615 Malate/L-lactate dehydrogenase 13 322 5.7E-90 T 17-03-2017 IPR003767 Malate/L-lactate dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 Pfam PF07687 Peptidase dimerisation domain 204 291 1.5E-5 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 SUPERFAMILY SSF55031 200 313 9.57E-21 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 Pfam PF01546 Peptidase family M20/M25/M40 87 400 9.8E-27 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 Gene3D G3DSA:3.40.630.10 315 401 7.1E-86 T 17-03-2017 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 Gene3D G3DSA:3.40.630.10 22 195 7.1E-86 T 17-03-2017 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 TIGRFAM TIGR01891 amidohydrolases: amidohydrolase 28 392 3.8E-97 T 17-03-2017 IPR017439 Amidohydrolase GO:0016787 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 Gene3D G3DSA:3.30.70.360 199 314 1.1E-27 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 SUPERFAMILY SSF53187 315 401 3.35E-64 T 17-03-2017 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 SUPERFAMILY SSF53187 22 214 3.35E-64 T 17-03-2017 SHXM_RS24925 480885257fbc35b662c5e50f3c4265b1 403 PIRSF PIRSF005962 18 403 4.9E-97 T 17-03-2017 IPR017439 Amidohydrolase GO:0016787 SHXM_RS34070 845e1d08b70e2eb5eed66e03dae68331 286 ProSitePatterns PS00793 Dihydropteroate synthase signature 2. 50 63 - T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS34070 845e1d08b70e2eb5eed66e03dae68331 286 Gene3D G3DSA:3.20.20.20 14 274 1.1E-84 T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS34070 845e1d08b70e2eb5eed66e03dae68331 286 TIGRFAM TIGR01496 DHPS: dihydropteroate synthase 16 271 2.9E-81 T 17-03-2017 IPR006390 Dihydropteroate synthase GO:0004156|GO:0009396 KEGG: 00790+2.5.1.15|MetaCyc: PWY-6614 SHXM_RS34070 845e1d08b70e2eb5eed66e03dae68331 286 Pfam PF00809 Pterin binding enzyme 17 257 8.1E-65 T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS34070 845e1d08b70e2eb5eed66e03dae68331 286 ProSitePatterns PS00792 Dihydropteroate synthase signature 1. 16 31 - T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS34070 845e1d08b70e2eb5eed66e03dae68331 286 SUPERFAMILY SSF51717 5 276 4.84E-82 T 17-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS20200 217304028d58e22eba79ddc5a2664927 404 Pfam PF02342 TerD domain 1 179 2.0E-41 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS20200 217304028d58e22eba79ddc5a2664927 404 Gene3D G3DSA:2.60.60.30 16 176 3.3E-25 T 17-03-2017 SHXM_RS28435 e08fbc426eb8e4792c90e93089ae76ec 388 Gene3D G3DSA:3.40.50.970 11 373 2.7E-132 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28435 e08fbc426eb8e4792c90e93089ae76ec 388 TIGRFAM TIGR03181 PDH_E1_alph_x: pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit 35 373 6.7E-139 T 17-03-2017 IPR017596 Pyruvate dehydrogenase E1 component subunit alpha/BCKADH E1-alpha KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS28435 e08fbc426eb8e4792c90e93089ae76ec 388 Pfam PF00676 Dehydrogenase E1 component 65 346 4.0E-80 T 17-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SHXM_RS28435 e08fbc426eb8e4792c90e93089ae76ec 388 SUPERFAMILY SSF52518 37 377 6.97E-100 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 Gene3D G3DSA:2.40.110.10 129 223 6.5E-40 T 17-03-2017 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 384 1.7E-50 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 15 125 7.0E-24 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 Gene3D G3DSA:1.10.540.10 15 125 4.5E-29 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 SUPERFAMILY SSF47203 234 386 3.22E-59 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 SUPERFAMILY SSF56645 13 248 4.19E-75 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 Gene3D G3DSA:1.20.140.10 224 386 2.3E-70 T 17-03-2017 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 343 362 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 PIRSF PIRSF016578 5 389 4.2E-19 T 17-03-2017 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 ProSitePatterns PS00072 Acyl-CoA dehydrogenases signature 1. 132 144 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS11585 7a61333aa90189baad3c9670092cfae2 390 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 130 224 2.2E-27 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 370 480 4.2E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 Pfam PF00672 HAMP domain 174 246 9.5E-11 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 Gene3D G3DSA:3.30.565.10 313 481 2.7E-43 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 SMART SM00387 370 482 7.9E-40 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 Gene3D G3DSA:1.10.287.130 252 312 5.0E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 Pfam PF00512 His Kinase A (phospho-acceptor) domain 261 327 5.7E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 SMART SM00304 192 252 5.5E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 SUPERFAMILY SSF47384 248 328 5.3E-20 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 SUPERFAMILY SSF55874 316 480 1.57E-39 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 426 436 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 466 479 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 443 461 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 PRINTS PR00344 Bacterial sensor protein C-terminal signature 408 422 2.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS43050 be606bff2747fffafa20a7f14cda8976 488 SMART SM00388 260 327 1.9E-22 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35485 e7efe0c740c515182d3f68ea2ef38e4a 578 Gene3D G3DSA:3.20.20.240 40 572 1.0E-213 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS35485 e7efe0c740c515182d3f68ea2ef38e4a 578 TIGRFAM TIGR00641 acid_CoA_mut_N: methylmalonyl-CoA mutase N-terminal domain 41 576 2.6E-197 T 17-03-2017 IPR006098 Methylmalonyl-CoA mutase, alpha chain, catalytic GO:0004494|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS35485 e7efe0c740c515182d3f68ea2ef38e4a 578 Pfam PF01642 Methylmalonyl-CoA mutase 41 570 1.6E-210 T 17-03-2017 IPR006099 Methylmalonyl-CoA mutase, alpha/beta chain, catalytic GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS35485 e7efe0c740c515182d3f68ea2ef38e4a 578 SUPERFAMILY SSF51703 21 572 7.85E-190 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS14480 962917d8c97a466e6a7990b18687e91c 242 SUPERFAMILY SSF46689 18 77 1.03E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14480 962917d8c97a466e6a7990b18687e91c 242 Gene3D G3DSA:1.10.357.10 75 225 6.7E-26 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS14480 962917d8c97a466e6a7990b18687e91c 242 Gene3D G3DSA:1.10.10.60 8 74 1.7E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14480 962917d8c97a466e6a7990b18687e91c 242 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 83 178 1.2E-8 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS14480 962917d8c97a466e6a7990b18687e91c 242 SUPERFAMILY SSF48498 88 225 8.56E-24 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS14480 962917d8c97a466e6a7990b18687e91c 242 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 70 1.7E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27565 505f202e07e2638cb8415d893bf3a29c 163 Pfam PF01575 MaoC like domain 11 111 1.0E-9 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS27565 505f202e07e2638cb8415d893bf3a29c 163 SUPERFAMILY SSF54637 3 128 2.98E-20 T 17-03-2017 IPR029069 HotDog domain SHXM_RS27565 505f202e07e2638cb8415d893bf3a29c 163 Gene3D G3DSA:3.10.129.10 2 126 2.4E-18 T 17-03-2017 IPR029069 HotDog domain SHXM_RS04090 6305dbcf954193c993c8e17412f6bff7 67 SUPERFAMILY SSF160582 2 64 2.22E-28 T 17-03-2017 SHXM_RS04090 6305dbcf954193c993c8e17412f6bff7 67 Pfam PF03621 MbtH-like protein 2 48 2.6E-22 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS04090 6305dbcf954193c993c8e17412f6bff7 67 Gene3D G3DSA:3.90.820.10 6 64 2.9E-31 T 17-03-2017 SHXM_RS04090 6305dbcf954193c993c8e17412f6bff7 67 SMART SM00923 2 48 2.3E-20 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 7.6E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 7.6E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 7.6E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 Gene3D G3DSA:3.40.190.10 87 225 4.9E-19 T 17-03-2017 SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 Gene3D G3DSA:1.10.10.10 1 85 3.0E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 SUPERFAMILY SSF53850 87 291 2.04E-23 T 17-03-2017 SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 SUPERFAMILY SSF46785 3 87 6.66E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 2.4E-17 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40495 9b1f2800700089dabeacf1c06be667e9 310 Pfam PF03466 LysR substrate binding domain 87 290 4.6E-23 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS13540 8bbc93a7f8abe048169e325aafa62367 485 SUPERFAMILY SSF103473 11 218 4.45E-48 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS13540 8bbc93a7f8abe048169e325aafa62367 485 Gene3D G3DSA:1.20.1250.20 271 454 1.3E-19 T 17-03-2017 SHXM_RS13540 8bbc93a7f8abe048169e325aafa62367 485 Pfam PF07690 Major Facilitator Superfamily 25 292 1.2E-29 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS13540 8bbc93a7f8abe048169e325aafa62367 485 SUPERFAMILY SSF103473 213 454 2.88E-24 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS13540 8bbc93a7f8abe048169e325aafa62367 485 Gene3D G3DSA:1.20.1250.20 19 201 1.7E-33 T 17-03-2017 SHXM_RS36145 6e4e413d21862b50ffbda4dd92c8a0c0 308 Gene3D G3DSA:3.40.50.720 52 109 4.5E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36145 6e4e413d21862b50ffbda4dd92c8a0c0 308 SUPERFAMILY SSF52283 53 113 4.42E-6 T 17-03-2017 SHXM_RS36145 6e4e413d21862b50ffbda4dd92c8a0c0 308 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 101 273 2.4E-45 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS36145 6e4e413d21862b50ffbda4dd92c8a0c0 308 Gene3D G3DSA:3.40.50.720 110 274 3.3E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36145 6e4e413d21862b50ffbda4dd92c8a0c0 308 SUPERFAMILY SSF51735 95 274 2.09E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36145 6e4e413d21862b50ffbda4dd92c8a0c0 308 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 213 229 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS26420 d60662f0ef7302dab32d8405ba6827a5 292 TIGRFAM TIGR01496 DHPS: dihydropteroate synthase 21 281 4.8E-90 T 17-03-2017 IPR006390 Dihydropteroate synthase GO:0004156|GO:0009396 KEGG: 00790+2.5.1.15|MetaCyc: PWY-6614 SHXM_RS26420 d60662f0ef7302dab32d8405ba6827a5 292 ProSitePatterns PS00793 Dihydropteroate synthase signature 2. 55 68 - T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS26420 d60662f0ef7302dab32d8405ba6827a5 292 SUPERFAMILY SSF51717 19 282 8.77E-92 T 17-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS26420 d60662f0ef7302dab32d8405ba6827a5 292 ProSitePatterns PS00792 Dihydropteroate synthase signature 1. 21 36 - T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS26420 d60662f0ef7302dab32d8405ba6827a5 292 Gene3D G3DSA:3.20.20.20 17 284 2.3E-104 T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS26420 d60662f0ef7302dab32d8405ba6827a5 292 Pfam PF00809 Pterin binding enzyme 22 267 1.3E-83 T 17-03-2017 IPR000489 Pterin-binding domain GO:0042558 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 Gene3D G3DSA:3.30.450.40 40 196 5.0E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 Gene3D G3DSA:3.30.450.40 209 360 9.4E-21 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 Pfam PF07730 Histidine kinase 374 436 2.5E-9 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 SUPERFAMILY SSF55781 33 216 1.2E-38 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 Gene3D G3DSA:3.30.565.10 471 567 2.1E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 SMART SM00065 219 366 3.4E-7 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 SMART SM00065 51 198 9.0E-19 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 SUPERFAMILY SSF55874 477 567 8.08E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 SMART SM00387 479 569 1.7E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 Pfam PF13185 GAF domain 219 356 8.8E-15 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 Pfam PF13185 GAF domain 50 189 8.4E-19 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS08040 d955db00da1057430fccb131ea1ae80d 570 SUPERFAMILY SSF55781 200 383 3.49E-25 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS36895 f4b714025db9ebab8757d7754244dad5 314 SUPERFAMILY SSF56112 38 294 7.75E-18 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS36895 f4b714025db9ebab8757d7754244dad5 314 Gene3D G3DSA:3.90.1200.10 135 288 3.9E-7 T 17-03-2017 SHXM_RS36895 f4b714025db9ebab8757d7754244dad5 314 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 51 297 2.0E-52 T 17-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 SUPERFAMILY SSF56801 8 542 3.14E-133 T 17-03-2017 SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 Gene3D G3DSA:3.40.50.980 192 341 3.9E-37 T 17-03-2017 SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 Pfam PF00501 AMP-binding enzyme 25 446 4.2E-82 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 ProSitePatterns PS00455 Putative AMP-binding domain signature. 185 196 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 Gene3D G3DSA:2.30.38.10 359 440 1.6E-16 T 17-03-2017 SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 Pfam PF13193 AMP-binding enzyme C-terminal domain 455 530 1.0E-16 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 Gene3D G3DSA:3.40.50.980 49 191 3.0E-26 T 17-03-2017 SHXM_RS27545 2ab7eedbce7e34110aa3c9ca6a518ac3 551 Gene3D G3DSA:3.30.300.30 441 540 8.0E-28 T 17-03-2017 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 SMART SM01130 10 295 6.1E-123 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 Hamap MF_00418 4-hydroxy-tetrahydrodipicolinate synthase [dapA]. 10 294 57.646 T 17-03-2017 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 PIRSF PIRSF001365 6 298 4.7E-83 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 SUPERFAMILY SSF51569 8 294 1.88E-96 T 17-03-2017 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 ProSitePatterns PS00665 Dihydrodipicolinate synthase signature 1. 47 64 - T 17-03-2017 IPR020624 Schiff base-forming aldolase, conserved site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 Gene3D G3DSA:3.20.20.70 8 295 3.9E-108 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 ProSitePatterns PS00666 Dihydrodipicolinate synthase signature 2. 142 172 - T 17-03-2017 IPR020625 Schiff base-forming aldolase, active site GO:0008152|GO:0016829 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 80 98 1.6E-31 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 112 128 1.6E-31 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 137 154 1.6E-31 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 PRINTS PR00146 Dihydrodipicolinate synthase signature 44 65 1.6E-31 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 Pfam PF00701 Dihydrodipicolinate synthetase family 11 293 1.4E-85 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS37105 9d1a05af4892101357ac7934727904cb 299 TIGRFAM TIGR00674 dapA: 4-hydroxy-tetrahydrodipicolinate synthase 14 290 3.7E-86 T 17-03-2017 IPR005263 4-hydroxy-tetrahydrodipicolinate synthase, DapA GO:0008840|GO:0009089 KEGG: 00261+4.3.3.7|KEGG: 00300+4.3.3.7|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 Gene3D G3DSA:1.10.10.10 8 88 1.5E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 SUPERFAMILY SSF46785 7 118 1.5E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 SUPERFAMILY SSF53850 96 304 4.13E-41 T 17-03-2017 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 Gene3D G3DSA:3.40.190.10 97 183 9.1E-20 T 17-03-2017 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 35 45 3.3E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 24 35 3.3E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 45 56 3.3E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 11 69 9.9E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 Gene3D G3DSA:3.40.190.10 184 272 1.6E-31 T 17-03-2017 SHXM_RS44230 14fbe4f6c68d30472d7bfcdbfddf2732 308 Pfam PF03466 LysR substrate binding domain 95 300 6.4E-42 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 SUPERFAMILY SSF90123 47 347 1.24E-20 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 SMART SM00382 395 603 2.0E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 Gene3D G3DSA:3.40.50.300 369 621 2.0E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 Gene3D G3DSA:1.20.1560.10 47 338 8.8E-17 T 17-03-2017 SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 SUPERFAMILY SSF52540 359 627 1.09E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 ProSitePatterns PS00211 ABC transporters family signature. 525 539 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS46620 d1d1b209d5fdc9bf41dbe587995a45ab 646 Pfam PF00005 ABC transporter 386 557 9.6E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45115 f2f9897d0bb32f9cad64cfb1c1a84a23 178 Gene3D G3DSA:1.10.10.10 1 85 6.6E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45115 f2f9897d0bb32f9cad64cfb1c1a84a23 178 SUPERFAMILY SSF46785 2 174 3.49E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45115 f2f9897d0bb32f9cad64cfb1c1a84a23 178 Pfam PF03551 Transcriptional regulator PadR-like family 6 79 7.8E-16 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 Pfam PF06827 Zinc finger found in FPG and IleRS 245 272 7.6E-7 T 17-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 89 2.3E-14 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 SMART SM00898 2 124 1.8E-20 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 SUPERFAMILY SSF57716 227 273 1.14E-11 T 17-03-2017 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 SUPERFAMILY SSF81624 2 147 4.45E-23 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 Gene3D G3DSA:3.20.190.10 2 138 1.2E-17 T 17-03-2017 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 Gene3D G3DSA:1.10.8.50 139 273 1.3E-35 T 17-03-2017 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 SUPERFAMILY SSF46946 137 220 1.3E-23 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 138 222 7.2E-21 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS07155 7bad6c29861aab749494ef7a4c14a495 288 SMART SM01232 138 230 3.7E-30 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS44030 ad94f3a594737fdfdf314aca1ddc8a21 331 SUPERFAMILY SSF103481 79 178 7.45E-12 T 17-03-2017 SHXM_RS44030 ad94f3a594737fdfdf314aca1ddc8a21 331 Pfam PF00892 EamA-like transporter family 51 177 6.1E-18 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS44030 ad94f3a594737fdfdf314aca1ddc8a21 331 Pfam PF00892 EamA-like transporter family 189 324 5.7E-20 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS44030 ad94f3a594737fdfdf314aca1ddc8a21 331 SUPERFAMILY SSF103481 227 328 1.96E-12 T 17-03-2017 SHXM_RS10990 b302c1dd9197f36b7c9fb587ceee51be 949 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 544 640 1.0E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10990 b302c1dd9197f36b7c9fb587ceee51be 949 Pfam PF00672 HAMP domain 342 424 4.0E-8 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS10990 b302c1dd9197f36b7c9fb587ceee51be 949 SMART SM00387 540 653 1.2E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10990 b302c1dd9197f36b7c9fb587ceee51be 949 SUPERFAMILY SSF55874 528 650 3.14E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10990 b302c1dd9197f36b7c9fb587ceee51be 949 Gene3D G3DSA:3.30.565.10 506 653 5.1E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10990 b302c1dd9197f36b7c9fb587ceee51be 949 Pfam PF08376 Nitrate and nitrite sensing 77 322 3.4E-31 T 17-03-2017 IPR013587 Nitrate/nitrite sensing protein SHXM_RS49700 47a1b3cc738b4a9eb038a554201e8079 346 PIRSF PIRSF039012 1 345 4.6E-70 T 17-03-2017 IPR007036 Succinylglutamate desuccinylase/aspartoacylase GO:0008152|GO:0016788 SHXM_RS49700 47a1b3cc738b4a9eb038a554201e8079 346 Pfam PF04952 Succinylglutamate desuccinylase / Aspartoacylase family 54 339 2.7E-57 T 17-03-2017 IPR007036 Succinylglutamate desuccinylase/aspartoacylase GO:0008152|GO:0016788 SHXM_RS49700 47a1b3cc738b4a9eb038a554201e8079 346 SUPERFAMILY SSF53187 26 341 9.59E-52 T 17-03-2017 SHXM_RS49700 47a1b3cc738b4a9eb038a554201e8079 346 Gene3D G3DSA:3.40.630.10 26 243 2.2E-26 T 17-03-2017 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 SUPERFAMILY SSF53850 91 296 9.93E-22 T 17-03-2017 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 Gene3D G3DSA:3.40.190.10 92 169 8.9E-6 T 17-03-2017 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 Gene3D G3DSA:1.10.10.10 1 80 6.4E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 SUPERFAMILY SSF46785 1 78 2.27E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 5.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 5.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 5.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 Pfam PF03466 LysR substrate binding domain 92 295 6.6E-21 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 Gene3D G3DSA:3.40.190.10 170 261 5.7E-15 T 17-03-2017 SHXM_RS27875 6741ff42ec6535f6b574b1e83913c5be 299 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 61 4.8E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Gene3D G3DSA:1.10.510.10 98 271 5.1E-50 T 17-03-2017 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Pfam PF00069 Protein kinase domain 11 264 2.1E-50 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 17 40 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Gene3D G3DSA:3.30.200.20 4 94 1.7E-30 T 17-03-2017 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SUPERFAMILY SSF54184 452 511 5.63E-5 T 17-03-2017 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Pfam PF03793 PASTA domain 452 512 1.2E-14 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Pfam PF03793 PASTA domain 518 580 7.3E-15 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Pfam PF03793 PASTA domain 381 444 2.8E-10 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 Pfam PF03793 PASTA domain 586 644 1.9E-10 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SUPERFAMILY SSF54184 517 578 2.22E-5 T 17-03-2017 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SMART SM00220 11 277 2.2E-68 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 134 146 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SMART SM00740 514 580 1.4E-16 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SMART SM00740 582 646 2.8E-8 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SMART SM00740 377 444 1.2E-10 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SMART SM00740 448 513 6.7E-14 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28245 b0ca565b0e06085c52fb7b529c496e70 670 SUPERFAMILY SSF56112 7 273 1.75E-78 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS19035 904ce954a4a32d4be692d76a702ed0b6 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 98 109 6.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19035 904ce954a4a32d4be692d76a702ed0b6 308 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 6.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19035 904ce954a4a32d4be692d76a702ed0b6 308 SUPERFAMILY SSF51735 9 267 1.35E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19035 904ce954a4a32d4be692d76a702ed0b6 308 Pfam PF00106 short chain dehydrogenase 13 214 2.7E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19035 904ce954a4a32d4be692d76a702ed0b6 308 Gene3D G3DSA:3.40.50.720 9 266 3.5E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 Pfam PF01047 MarR family 39 89 1.8E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 Gene3D G3DSA:1.10.10.10 29 138 4.0E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 SMART SM00347 25 125 7.1E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 115 135 1.6E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 49 65 1.6E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 85 101 1.6E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 66 81 1.6E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS27380 a750fea2acff6cacb5a6e14426bbd251 162 SUPERFAMILY SSF46785 33 139 2.6E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43645 a68214a774f79c09417b8266994d74d2 367 Gene3D G3DSA:3.90.1200.10 150 302 3.0E-13 T 17-03-2017 SHXM_RS43645 a68214a774f79c09417b8266994d74d2 367 SUPERFAMILY SSF56112 84 309 9.36E-28 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS43645 a68214a774f79c09417b8266994d74d2 367 Pfam PF01636 Phosphotransferase enzyme family 102 295 3.1E-21 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 ProSitePatterns PS00611 Histidinol dehydrogenase signature. 233 265 - T 17-03-2017 IPR001692 Histidinol dehydrogenase, conserved site GO:0000105|GO:0004399|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 Gene3D G3DSA:3.40.50.1980 30 243 2.8E-78 T 17-03-2017 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 204 229 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 137 163 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 174 200 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 233 254 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 367 385 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 326 351 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 255 274 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PRINTS PR00083 Histidinol dehydrogenase signature 36 60 2.0E-82 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 SUPERFAMILY SSF53720 28 435 7.26E-71 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 TIGRFAM TIGR00069 hisD: histidinol dehydrogenase 36 432 2.7E-141 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 Hamap MF_01024 Histidinol dehydrogenase [hisD]. 5 433 38.779 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 PIRSF PIRSF000099 12 436 4.7E-158 T 17-03-2017 IPR022695 Histidinol dehydrogenase, monofunctional GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS18420 bf1b8044dd576ea8c97a9fadff152b16 441 Pfam PF00815 Histidinol dehydrogenase 23 433 6.0E-157 T 17-03-2017 IPR012131 Histidinol dehydrogenase GO:0000105|GO:0004399|GO:0008270|GO:0051287|GO:0055114 KEGG: 00340+1.1.1.23 SHXM_RS46350 5151ac8bfd02c321323c50994b06a7e1 454 SUPERFAMILY SSF103473 15 443 4.58E-76 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS46350 5151ac8bfd02c321323c50994b06a7e1 454 ProSitePatterns PS00217 Sugar transport proteins signature 2. 128 153 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS46350 5151ac8bfd02c321323c50994b06a7e1 454 Pfam PF00083 Sugar (and other) transporter 59 444 5.5E-58 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS46350 5151ac8bfd02c321323c50994b06a7e1 454 Gene3D G3DSA:1.20.1250.20 39 212 4.1E-28 T 17-03-2017 SHXM_RS46350 5151ac8bfd02c321323c50994b06a7e1 454 Gene3D G3DSA:1.20.1250.20 257 439 6.0E-19 T 17-03-2017 SHXM_RS22550 5c5a33e503bd4eaf7b6522e758b811f2 262 SUPERFAMILY SSF63737 3 172 6.41E-19 T 17-03-2017 SHXM_RS22550 5c5a33e503bd4eaf7b6522e758b811f2 262 SUPERFAMILY SSF56219 207 262 1.57E-6 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS22550 5c5a33e503bd4eaf7b6522e758b811f2 262 Pfam PF01433 Peptidase family M1 3 223 6.2E-17 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS41655 5d96b7a8f65b07a53f325653fb8e1fb3 114 ProDom PD021009 GERMINATION MULTIGENE SPORE FAMILY SPORULATION PRECURSOR SIGNAL GENE SPG2 SPG1 30 110 1.0E-5 T 17-03-2017 SHXM_RS41655 5d96b7a8f65b07a53f325653fb8e1fb3 114 Pfam PF03995 Peptidase inhibitor family I36 26 81 1.0E-4 T 17-03-2017 SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 Pfam PF14561 Tetratricopeptide repeat 238 323 2.4E-21 T 17-03-2017 SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 Gene3D G3DSA:1.25.40.10 185 232 8.8E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 ProSitePatterns PS00194 Thioredoxin family active site. 69 87 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 Gene3D G3DSA:3.40.30.10 48 153 5.6E-30 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 SUPERFAMILY SSF52833 47 153 4.18E-31 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 Gene3D G3DSA:1.25.40.10 241 323 2.2E-12 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 Pfam PF14559 Tetratricopeptide repeat 197 232 4.8E-6 T 17-03-2017 SHXM_RS35495 94c5578c86b058112368adfd8416959a 323 Pfam PF00085 Thioredoxin 49 150 7.2E-24 T 17-03-2017 IPR013766 Thioredoxin domain GO:0045454 SHXM_RS03775 8577217fc6eb9b7bcb1377b1a03ac3d3 301 Gene3D G3DSA:3.60.10.10 47 300 1.9E-12 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS03775 8577217fc6eb9b7bcb1377b1a03ac3d3 301 SUPERFAMILY SSF56219 43 297 5.23E-36 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS03775 8577217fc6eb9b7bcb1377b1a03ac3d3 301 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 49 292 3.9E-13 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 50 187 2.0E-24 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 185 202 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 273 290 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 470 486 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 321 339 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 343 356 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 143 163 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 214 235 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 PRINTS PR00738 Glycosyl hydrolase family 20 signature 488 505 3.1E-49 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 SUPERFAMILY SSF51445 191 535 1.16E-110 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 Gene3D G3DSA:3.20.20.80 189 535 9.5E-111 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 Gene3D G3DSA:3.30.379.10 10 188 3.6E-36 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 191 360 5.1E-60 T 17-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 364 506 2.6E-26 T 17-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS22625 edfc78d10d04e6b86d1dc6dd6496a26b 544 SUPERFAMILY SSF55545 41 190 1.83E-31 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS28185 ad11c27b19535034fb6bfac871fe3774 182 SUPERFAMILY SSF47413 22 74 5.63E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28185 ad11c27b19535034fb6bfac871fe3774 182 Gene3D G3DSA:1.10.260.40 25 62 2.1E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 Gene3D G3DSA:3.50.50.60 2 199 1.9E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 Gene3D G3DSA:3.50.50.60 297 378 1.9E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 Pfam PF01494 FAD binding domain 308 371 1.2E-9 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 Pfam PF01494 FAD binding domain 2 192 4.5E-10 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 325 341 1.6E-20 T 17-03-2017 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 173 188 1.6E-20 T 17-03-2017 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 2 24 1.6E-20 T 17-03-2017 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 310 325 1.6E-20 T 17-03-2017 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 SUPERFAMILY SSF51905 2 194 9.07E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 SUPERFAMILY SSF51905 297 392 9.07E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03335 dbe92b37831fde7b531af7796227f14b 414 SUPERFAMILY SSF54373 199 301 2.16E-26 T 17-03-2017 SHXM_RS12235 d407fd9ca09f6774cb978700ae335f3b 266 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 144 164 - T 17-03-2017 IPR001110 Uncharacterised protein family UPF0012, conserved site SHXM_RS12235 d407fd9ca09f6774cb978700ae335f3b 266 SUPERFAMILY SSF56317 1 263 1.57E-64 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS12235 d407fd9ca09f6774cb978700ae335f3b 266 Pfam PF00795 Carbon-nitrogen hydrolase 5 245 2.3E-39 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS12235 d407fd9ca09f6774cb978700ae335f3b 266 Gene3D G3DSA:3.60.110.10 2 264 4.4E-66 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 Gene3D G3DSA:1.10.150.20 289 339 9.3E-12 T 17-03-2017 SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 Pfam PF02457 DisA bacterial checkpoint controller nucleotide-binding 16 129 2.5E-23 T 17-03-2017 IPR003390 DNA integrity scanning protein, DisA, N-terminal SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 SUPERFAMILY SSF143597 10 132 8.37E-26 T 17-03-2017 SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 Pfam PF12826 Helix-hairpin-helix motif 302 339 1.4E-6 T 17-03-2017 SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 SUPERFAMILY SSF47781 277 344 9.27E-12 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 Hamap MF_01438 DNA integrity scanning protein DisA [disA]. 1 349 43.419 T 17-03-2017 IPR023763 DNA integrity scanning protein, DisA SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 Pfam PF10635 DisA bacterial checkpoint controller linker region 133 275 3.0E-52 T 17-03-2017 IPR018906 DNA integrity scanning, DisA, linker region SHXM_RS30305 08013b05bd6fbb46dc4b55a1ae19d16c 352 Gene3D G3DSA:3.40.1700.10 9 132 4.9E-30 T 17-03-2017 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 SMART SM00898 2 125 5.6E-47 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 Gene3D G3DSA:3.20.190.10 2 130 1.1E-38 T 17-03-2017 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 Gene3D G3DSA:1.10.8.50 146 285 3.3E-47 T 17-03-2017 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 TIGRFAM TIGR00577 fpg: DNA-formamidopyrimidine glycosylase 1 284 5.6E-87 T 17-03-2017 IPR020629 Formamidopyrimidine-DNA glycosylase GO:0003906|GO:0006281|GO:0008270|GO:0008534 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 SMART SM01232 144 236 1.0E-43 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 SUPERFAMILY SSF81624 2 149 1.57E-33 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 SUPERFAMILY SSF57716 236 285 1.03E-15 T 17-03-2017 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 144 231 1.6E-22 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 ProSitePatterns PS01242 Zinc finger FPG-type signature. 260 284 - T 17-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 Pfam PF06827 Zinc finger found in FPG and IleRS 258 284 1.5E-4 T 17-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 Hamap MF_00103 Formamidopyrimidine-DNA glycosylase [mutM]. 1 285 41.883 T 17-03-2017 IPR020629 Formamidopyrimidine-DNA glycosylase GO:0003906|GO:0006281|GO:0008270|GO:0008534 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 2 123 8.2E-34 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS36460 6639a99ffb791680aef7f548c6ca51ff 310 SUPERFAMILY SSF46946 144 233 4.42E-27 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS41200 8d179391a375a484b7bb7da35a6cf6ce 163 SUPERFAMILY SSF50475 5 153 3.43E-35 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41200 8d179391a375a484b7bb7da35a6cf6ce 163 Gene3D G3DSA:2.30.110.10 2 154 6.7E-43 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41200 8d179391a375a484b7bb7da35a6cf6ce 163 Pfam PF01613 Flavin reductase like domain 11 153 2.3E-32 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS41200 8d179391a375a484b7bb7da35a6cf6ce 163 SMART SM00903 11 155 9.8E-41 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 Pfam PF00652 Ricin-type beta-trefoil lectin domain 345 477 4.2E-24 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 Pfam PF04616 Glycosyl hydrolases family 43 62 261 3.6E-19 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 Gene3D G3DSA:2.115.10.20 60 262 2.7E-26 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 SMART SM00458 343 480 9.8E-18 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 SUPERFAMILY SSF50370 343 477 3.44E-42 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 Gene3D G3DSA:2.80.10.50 347 477 8.2E-35 T 17-03-2017 SHXM_RS46145 c6f5fd73ccfd89b431b8895e8f16bbeb 480 SUPERFAMILY SSF75005 53 332 1.57E-49 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 2.1E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 2.1E-7 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 Gene3D G3DSA:3.40.50.1360 77 216 3.4E-8 T 17-03-2017 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 SUPERFAMILY SSF100950 77 233 2.18E-24 T 17-03-2017 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 SMART SM01134 74 234 6.5E-65 T 17-03-2017 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 Gene3D G3DSA:1.10.10.10 4 55 6.7E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 7.2E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 Pfam PF00455 DeoR C terminal sensor domain 77 233 1.4E-47 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 SUPERFAMILY SSF46785 5 64 8.73E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS49595 55d6cbe8e3b07213d450e94398e35790 258 SMART SM00420 6 58 7.3E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS02975 b382f76e25e2cf347757de7f1d127d70 278 Hamap MF_00691 UPF0271 protein YbgL [ybgL]. 3 246 42.495 T 17-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SHXM_RS02975 b382f76e25e2cf347757de7f1d127d70 278 Pfam PF03746 LamB/YcsF family 5 241 1.3E-90 T 17-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SHXM_RS02975 b382f76e25e2cf347757de7f1d127d70 278 SUPERFAMILY SSF88713 4 253 5.72E-89 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 504 694 1.1E-52 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 SUPERFAMILY SSF81606 492 695 1.28E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 SUPERFAMILY SSF55874 733 818 2.21E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 Pfam PF13581 Histidine kinase-like ATPase domain 713 801 5.2E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 SMART SM00331 478 694 3.9E-36 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 Gene3D G3DSA:3.30.450.40 266 454 3.3E-25 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS33595 5963544ace07d005483deb42ade921e2 821 SUPERFAMILY SSF55781 401 464 2.31E-7 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS22495 71c9050842ee831ac500da48937b2fa4 467 SUPERFAMILY SSF53474 367 419 1.01E-11 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22495 71c9050842ee831ac500da48937b2fa4 467 SUPERFAMILY SSF53474 88 201 1.01E-11 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22495 71c9050842ee831ac500da48937b2fa4 467 Gene3D G3DSA:3.40.50.1820 380 419 1.3E-10 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22495 71c9050842ee831ac500da48937b2fa4 467 Gene3D G3DSA:3.40.50.1820 121 288 1.3E-10 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22495 71c9050842ee831ac500da48937b2fa4 467 Pfam PF05576 PS-10 peptidase S37 31 467 1.8E-210 T 17-03-2017 IPR008761 Peptidase S37, tripeptidyl aminopeptidase SHXM_RS31950 e6cc35c5e04441ce9ed984d38216e0e0 494 SUPERFAMILY SSF53300 65 229 2.38E-21 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS31950 e6cc35c5e04441ce9ed984d38216e0e0 494 SMART SM00327 61 239 1.2E-12 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS31950 e6cc35c5e04441ce9ed984d38216e0e0 494 Gene3D G3DSA:3.40.50.410 65 218 1.9E-9 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS31950 e6cc35c5e04441ce9ed984d38216e0e0 494 Pfam PF13768 von Willebrand factor type A domain 65 221 3.6E-13 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 SMART SM00382 235 419 3.5E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 Pfam PF01078 Magnesium chelatase, subunit ChlI 215 422 1.0E-86 T 17-03-2017 IPR000523 Magnesium chelatase ChlI domain SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 Pfam PF13335 Magnesium chelatase, subunit ChlI C-terminal 431 526 4.0E-23 T 17-03-2017 IPR025158 Mg chelatase-related protein, C-terminal domain SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 Pfam PF13541 Subunit ChlI of Mg-chelatase 21 142 7.6E-38 T 17-03-2017 SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 Gene3D G3DSA:3.40.50.300 215 414 2.0E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 Gene3D G3DSA:3.30.230.10 7 169 2.7E-37 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 SUPERFAMILY SSF52540 489 526 4.0E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 SUPERFAMILY SSF52540 215 447 4.0E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36630 cf955cbfef24eea50240f8ef3bbf019a 540 SUPERFAMILY SSF54211 2 170 2.01E-36 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS47950 e52cea368ba79132dd5241fba5739989 161 Pfam PF13924 Lipocalin-like domain 25 159 5.2E-39 T 17-03-2017 IPR024311 Lipocalin-like domain SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 Pfam PF01047 MarR family 54 111 9.8E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 SMART SM00347 43 146 1.2E-23 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 SUPERFAMILY SSF46785 11 160 4.01E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 136 156 4.0E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 70 86 4.0E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 106 122 4.0E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 PRINTS PR00598 Bacterial regulatory protein MarR family signature 87 102 4.0E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 Gene3D G3DSA:1.10.10.10 9 160 1.2E-38 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32735 cbfbb41dddb1cb9c932124c276e66d98 165 ProSitePatterns PS01117 MarR-type HTH domain signature. 85 119 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 144 214 8.4E-20 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 SMART SM00898 2 117 2.0E-24 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 SUPERFAMILY SSF46946 132 214 5.5E-23 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 SUPERFAMILY SSF81624 2 137 4.19E-25 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 Gene3D G3DSA:3.20.190.10 2 125 2.5E-26 T 17-03-2017 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 SUPERFAMILY SSF57716 211 259 2.4E-9 T 17-03-2017 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 SMART SM01232 132 221 2.5E-30 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 113 6.7E-25 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 ProSitePatterns PS01242 Zinc finger FPG-type signature. 234 258 - T 17-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 Gene3D G3DSA:1.10.8.50 133 259 3.9E-33 T 17-03-2017 SHXM_RS07040 3bc7d1bcf3605f31016de17c8624cc69 262 Pfam PF06827 Zinc finger found in FPG and IleRS 234 258 3.0E-5 T 17-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 SHXM_RS13665 fe1b896da0b176e38f67a2aa44375166 184 Gene3D G3DSA:3.40.50.360 1 174 1.9E-35 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS13665 fe1b896da0b176e38f67a2aa44375166 184 Pfam PF03358 NADPH-dependent FMN reductase 4 144 9.7E-31 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS13665 fe1b896da0b176e38f67a2aa44375166 184 SUPERFAMILY SSF52218 3 170 7.61E-34 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS13665 fe1b896da0b176e38f67a2aa44375166 184 TIGRFAM TIGR03567 FMN_reduc_SsuE: FMN reductase 3 171 1.9E-67 T 17-03-2017 IPR020048 NADPH-dependent FMN reductase, SsuE GO:0008752|GO:0046306|GO:0055114 KEGG: 00740+1.5.1.38|MetaCyc: PWY-7723 SHXM_RS41740 556d7e7a42646baba6d1cf2219ad3c07 360 Gene3D G3DSA:1.50.10.10 13 348 4.4E-121 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS41740 556d7e7a42646baba6d1cf2219ad3c07 360 Pfam PF07470 Glycosyl Hydrolase Family 88 27 306 2.5E-23 T 17-03-2017 IPR010905 Glycosyl hydrolase, family 88 SHXM_RS41740 556d7e7a42646baba6d1cf2219ad3c07 360 SUPERFAMILY SSF48208 18 347 3.74E-101 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS08440 4dec0044e0779e0e8e6babd6430e9915 351 Gene3D G3DSA:3.40.50.720 6 305 5.6E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08440 4dec0044e0779e0e8e6babd6430e9915 351 Pfam PF01370 NAD dependent epimerase/dehydratase family 7 222 1.2E-10 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS08440 4dec0044e0779e0e8e6babd6430e9915 351 SUPERFAMILY SSF51735 6 312 1.49E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37785 c056358ac4ec3e3407dd8a4569947db7 169 Gene3D G3DSA:3.10.129.10 2 148 3.6E-34 T 17-03-2017 IPR029069 HotDog domain SHXM_RS37785 c056358ac4ec3e3407dd8a4569947db7 169 Pfam PF07977 FabA-like domain 11 140 3.7E-14 T 17-03-2017 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS37785 c056358ac4ec3e3407dd8a4569947db7 169 SUPERFAMILY SSF54637 1 148 1.4E-27 T 17-03-2017 IPR029069 HotDog domain SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 4.5E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.4E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.4E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.4E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 SUPERFAMILY SSF53850 90 281 2.29E-22 T 17-03-2017 SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 Gene3D G3DSA:1.10.10.10 1 84 3.6E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 Gene3D G3DSA:3.40.190.10 90 196 5.5E-16 T 17-03-2017 SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 Pfam PF03466 LysR substrate binding domain 88 279 1.7E-22 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46415 db8cca2ba760c49bc4d45229242bb0eb 283 SUPERFAMILY SSF46785 1 83 1.51E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37920 0395b53034a6b7cadf2ee3cba34ef00c 114 Gene3D G3DSA:1.10.287.1080 8 102 2.7E-22 T 17-03-2017 SHXM_RS37920 0395b53034a6b7cadf2ee3cba34ef00c 114 SUPERFAMILY SSF101386 8 111 6.76E-32 T 17-03-2017 SHXM_RS37920 0395b53034a6b7cadf2ee3cba34ef00c 114 PIRSF PIRSF029826 4 114 2.2E-40 T 17-03-2017 IPR011394 NTP Pyrophosphohydrolase MazG-related, RS21-C6 SHXM_RS37920 0395b53034a6b7cadf2ee3cba34ef00c 114 Pfam PF12643 MazG-like family 39 110 4.5E-10 T 17-03-2017 IPR025984 MazG-like domain KEGG: 00240+3.6.1.12|Reactome: R-HSA-499943 SHXM_RS49185 1ece9e0e760d821869ffe79abed1d2a6 209 Pfam PF06527 TniQ 38 171 6.0E-9 T 17-03-2017 IPR009492 TniQ SHXM_RS43270 8818449d55bf206b0f2048b463fbc31d 373 Gene3D G3DSA:3.40.50.1100 65 161 5.3E-23 T 17-03-2017 SHXM_RS43270 8818449d55bf206b0f2048b463fbc31d 373 Gene3D G3DSA:3.40.50.1100 162 353 1.4E-34 T 17-03-2017 SHXM_RS43270 8818449d55bf206b0f2048b463fbc31d 373 SUPERFAMILY SSF53686 41 354 6.55E-69 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS43270 8818449d55bf206b0f2048b463fbc31d 373 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 49 333 2.6E-44 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS48405 485f70b92ce37e8a6a52cf1542f82e5d 335 SUPERFAMILY SSF51430 1 313 3.27E-54 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS48405 485f70b92ce37e8a6a52cf1542f82e5d 335 Pfam PF00248 Aldo/keto reductase family 15 313 9.6E-35 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS48405 485f70b92ce37e8a6a52cf1542f82e5d 335 Gene3D G3DSA:3.20.20.100 1 313 1.5E-45 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS05010 3357fe775fc70df17a68315c686b99bc 235 SUPERFAMILY SSF102114 33 105 7.06E-8 T 17-03-2017 SHXM_RS05010 3357fe775fc70df17a68315c686b99bc 235 Pfam PF13353 4Fe-4S single cluster domain 25 170 4.0E-19 T 17-03-2017 SHXM_RS05010 3357fe775fc70df17a68315c686b99bc 235 Gene3D G3DSA:3.20.20.70 34 102 1.4E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 SUPERFAMILY SSF53955 63 284 1.1E-68 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 Gene3D G3DSA:3.40.710.10 264 697 3.1E-110 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 Pfam PF00912 Transglycosylase 77 261 4.8E-63 T 17-03-2017 IPR001264 Glycosyl transferase, family 51 SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 Gene3D G3DSA:1.10.3810.10 77 263 2.0E-70 T 17-03-2017 SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 SUPERFAMILY SSF56601 243 265 2.53E-95 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 SUPERFAMILY SSF56601 299 680 2.53E-95 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS27040 126dd545dc634baaeccf99c2b64e25b1 752 Pfam PF00905 Penicillin binding protein transpeptidase domain 362 630 2.5E-33 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS03060 2fa52b7d09c8751b51e96005e645eac2 339 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 231 323 3.4E-12 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS03060 2fa52b7d09c8751b51e96005e645eac2 339 Gene3D G3DSA:3.40.47.10 165 322 4.8E-19 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03060 2fa52b7d09c8751b51e96005e645eac2 339 SUPERFAMILY SSF53901 5 323 1.73E-27 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03060 2fa52b7d09c8751b51e96005e645eac2 339 Gene3D G3DSA:3.40.47.10 5 164 2.4E-15 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 SUPERFAMILY SSF51735 128 316 1.26E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 Gene3D G3DSA:3.40.50.720 60 136 2.2E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 61 347 5.5E-18 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 Gene3D G3DSA:3.40.50.720 137 317 5.8E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 136 315 3.1E-52 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 254 270 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS41600 836dab46bd5edc881bfb3176dc29c4ee 356 SUPERFAMILY SSF52283 62 163 7.65E-23 T 17-03-2017 SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 Gene3D G3DSA:3.40.50.150 4 95 4.9E-18 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 SUPERFAMILY SSF53335 23 200 2.47E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 ProSitePatterns PS00093 N-4 cytosine-specific DNA methylases signature. 129 134 - T 17-03-2017 IPR017985 DNA methylase, N-4 cytosine-specific, conserved site GO:0003677|GO:0015667|GO:0090124 KEGG: 00860+2.1.1.11|MetaCyc: PWY-5531|MetaCyc: PWY-7159 SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 72 92 4.0E-8 T 17-03-2017 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 30 47 4.0E-8 T 17-03-2017 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 PRINTS PR00508 S21 class N4 adenine-specific DNA methyltransferase signature 49 67 4.0E-8 T 17-03-2017 IPR001091 Restriction/modification DNA-methylase GO:0003677|GO:0006306|GO:0008170 SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 Gene3D G3DSA:3.40.50.150 103 290 3.7E-13 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08750 fbb24e04b933f1a70db455490e3a52fc 318 Pfam PF01555 DNA methylase 6 87 2.8E-14 T 17-03-2017 IPR002941 DNA methylase N-4/N-6 GO:0003677|GO:0006306|GO:0008170 SHXM_RS42585 15a53d2dc11f4c7c6fa03260fe6640e2 332 Pfam PF00296 Luciferase-like monooxygenase 18 294 4.2E-29 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42585 15a53d2dc11f4c7c6fa03260fe6640e2 332 Gene3D G3DSA:3.20.20.30 6 321 8.2E-70 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42585 15a53d2dc11f4c7c6fa03260fe6640e2 332 TIGRFAM TIGR03558 oxido_grp_1: luciferase family oxidoreductase, group 1 6 320 1.7E-102 T 17-03-2017 IPR019949 Luciferase family oxidoreductase, group 1 SHXM_RS42585 15a53d2dc11f4c7c6fa03260fe6640e2 332 SUPERFAMILY SSF51679 6 321 2.09E-63 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 PRINTS PR00340 P-II protein signature 2 17 7.7E-37 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 PRINTS PR00340 P-II protein signature 52 75 7.7E-37 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 PRINTS PR00340 P-II protein signature 23 41 7.7E-37 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 PRINTS PR00340 P-II protein signature 83 103 7.7E-37 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 ProSitePatterns PS00496 P-II protein uridylation site. 46 51 - T 17-03-2017 IPR002332 Nitrogen regulatory protein P-II, urydylation site GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 PIRSF PIRSF039144 1 112 4.9E-49 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 SUPERFAMILY SSF54913 2 112 7.63E-41 T 17-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 SMART SM00938 4 105 8.2E-57 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 Gene3D G3DSA:3.30.70.120 2 112 2.5E-44 T 17-03-2017 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal SHXM_RS36540 0f2fb8fabdfc232498c602e67c8f9e2e 112 Pfam PF00543 Nitrogen regulatory protein P-II 4 105 2.0E-39 T 17-03-2017 IPR002187 Nitrogen regulatory protein PII GO:0006808|GO:0030234 SHXM_RS42990 1cd15b208ac9d1102418fe066365a5ad 170 Pfam PF04314 Protein of unknown function (DUF461) 53 159 2.2E-18 T 17-03-2017 IPR007410 DR1885-like metal-binding protein SHXM_RS42990 1cd15b208ac9d1102418fe066365a5ad 170 SUPERFAMILY SSF110087 25 169 1.44E-24 T 17-03-2017 IPR007410 DR1885-like metal-binding protein SHXM_RS32190 b2fd7756eededd834c260ed1c255b5ef 911 Pfam PF13289 SIR2-like domain 155 277 3.7E-8 T 17-03-2017 SHXM_RS32190 b2fd7756eededd834c260ed1c255b5ef 911 SUPERFAMILY SSF52540 373 511 6.1E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41690 02ee0f13c03d13b63c60c71ec596dc05 347 SUPERFAMILY SSF53822 45 324 4.32E-42 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS41690 02ee0f13c03d13b63c60c71ec596dc05 347 Pfam PF13407 Periplasmic binding protein domain 46 295 2.8E-38 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS41690 02ee0f13c03d13b63c60c71ec596dc05 347 Gene3D G3DSA:3.40.50.2300 161 324 2.4E-26 T 17-03-2017 SHXM_RS41690 02ee0f13c03d13b63c60c71ec596dc05 347 Gene3D G3DSA:3.40.50.2300 42 160 4.1E-15 T 17-03-2017 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Gene3D G3DSA:3.40.50.300 361 408 4.6E-123 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Gene3D G3DSA:3.40.50.300 3 226 4.6E-123 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 405 418 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 115 125 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 99 113 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 331 353 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 61 85 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 368 385 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 PRINTS PR00906 SecA protein signature 168 188 6.6E-70 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 TIGRFAM TIGR00963 secA: preprotein translocase, SecA subunit 26 827 0.0 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SMART SM00957 4 394 4.3E-284 T 17-03-2017 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Pfam PF07516 SecA Wing and Scaffold domain 624 838 2.4E-65 T 17-03-2017 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Hamap MF_01382 Protein translocase subunit SecA [secA]. 3 841 20.017 T 17-03-2017 IPR000185 Protein translocase subunit SecA GO:0005524|GO:0006605|GO:0006886 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SUPERFAMILY SSF81886 627 851 4.05E-73 T 17-03-2017 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Pfam PF07517 SecA DEAD-like domain 6 393 1.1E-129 T 17-03-2017 IPR011115 SecA DEAD-like, N-terminal GO:0005524|GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Gene3D G3DSA:1.10.3060.10 655 839 8.7E-57 T 17-03-2017 IPR011116 SecA Wing/Scaffold GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SUPERFAMILY SSF52540 409 625 9.15E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SUPERFAMILY SSF52540 360 407 9.64E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SUPERFAMILY SSF52540 4 226 9.64E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Gene3D G3DSA:3.90.1440.10 229 360 1.1E-44 T 17-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SUPERFAMILY SSF81767 225 360 1.83E-40 T 17-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 SMART SM00958 226 350 7.3E-65 T 17-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Gene3D G3DSA:3.40.50.300 409 626 1.5E-93 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 ProSitePatterns PS01312 SecA family signature. 492 507 - T 17-03-2017 IPR020937 SecA conserved site GO:0006605|GO:0006886|GO:0016020 SHXM_RS24080 20c363a583510a456d58cdc289cd0857 947 Pfam PF01043 SecA preprotein cross-linking domain 251 350 1.3E-34 T 17-03-2017 IPR011130 SecA preprotein, cross-linking domain GO:0016020|GO:0017038 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 SMART SM00388 164 232 3.9E-14 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 PRINTS PR00344 Bacterial sensor protein C-terminal signature 370 383 4.7E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 PRINTS PR00344 Bacterial sensor protein C-terminal signature 332 342 4.7E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 PRINTS PR00344 Bacterial sensor protein C-terminal signature 346 364 4.7E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 PRINTS PR00344 Bacterial sensor protein C-terminal signature 314 328 4.7E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 SUPERFAMILY SSF47384 152 230 6.08E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 279 384 2.5E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 SUPERFAMILY SSF55874 221 385 7.99E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 Pfam PF00512 His Kinase A (phospho-acceptor) domain 165 230 1.2E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 Gene3D G3DSA:1.10.287.130 157 228 4.1E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 SMART SM00387 276 386 4.9E-29 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS46520 bd096b25ecebd11e19ee67ca321211ca 413 Gene3D G3DSA:3.30.565.10 235 387 2.7E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 87 4.3E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 Pfam PF13602 Zinc-binding dehydrogenase 187 336 2.7E-20 T 17-03-2017 SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 Gene3D G3DSA:3.90.180.10 5 146 3.3E-40 T 17-03-2017 IPR011032 GroES-like SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 SUPERFAMILY SSF50129 9 141 5.33E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 SUPERFAMILY SSF51735 113 257 4.66E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 SMART SM00829 9 336 2.5E-25 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS19145 6ee4ffb9dd76dfd979525b6f5aa8ee28 351 Gene3D G3DSA:3.40.50.720 147 242 2.6E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 SUPERFAMILY SSF48452 636 734 7.82E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 SMART SM00220 229 484 5.5E-13 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 Pfam PF00069 Protein kinase domain 232 429 5.2E-25 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 Gene3D G3DSA:1.10.510.10 316 429 8.0E-20 T 17-03-2017 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 SUPERFAMILY SSF56112 220 499 2.95E-40 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 Gene3D G3DSA:3.30.200.20 224 315 6.0E-13 T 17-03-2017 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 Pfam PF16918 Protein kinase G tetratricopeptide repeat 560 863 7.7E-91 T 17-03-2017 IPR031636 Protein kinase G, tetratricopeptide repeat containing domain KEGG: 04150+2.7.11.1|KEGG: 04151+2.7.11.1 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 Gene3D G3DSA:1.25.40.10 597 747 1.2E-12 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS21955 7616190d8ab18d37c8c9e0a9847612c6 865 Pfam PF16919 Protein kinase G rubredoxin domain 97 228 5.9E-41 T 17-03-2017 IPR031634 Protein kinase G, rubredoxin domain KEGG: 04150+2.7.11.1|KEGG: 04151+2.7.11.1 SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 Pfam PF00392 Bacterial regulatory proteins, gntR family 5 66 1.4E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 SUPERFAMILY SSF46785 4 81 1.87E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 Gene3D G3DSA:1.20.120.530 89 221 9.9E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 SMART SM00895 92 214 2.3E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 Gene3D G3DSA:1.10.10.10 4 70 6.8E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 Pfam PF07729 FCD domain 92 213 3.2E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 SMART SM00345 7 66 2.5E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 40 56 8.4E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 26 40 8.4E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS20890 6e66b44a3d305915fabe2c534fe57ae6 232 SUPERFAMILY SSF48008 88 221 2.88E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 SUPERFAMILY SSF56655 16 267 8.9E-56 T 17-03-2017 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 Gene3D G3DSA:3.40.190.80 178 271 2.3E-15 T 17-03-2017 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 94 107 - T 17-03-2017 IPR020583 Inositol monophosphatase, metal-binding site SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 PRINTS PR00377 Inositol monophosphatase superfamily signature 218 242 4.2E-22 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 PRINTS PR00377 Inositol monophosphatase superfamily signature 94 110 4.2E-22 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 PRINTS PR00377 Inositol monophosphatase superfamily signature 45 65 4.2E-22 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 PRINTS PR00377 Inositol monophosphatase superfamily signature 67 83 4.2E-22 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 PRINTS PR00377 Inositol monophosphatase superfamily signature 143 166 4.2E-22 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 PRINTS PR00377 Inositol monophosphatase superfamily signature 187 208 4.2E-22 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 ProSitePatterns PS00630 Inositol monophosphatase family signature 2. 221 235 - T 17-03-2017 IPR020550 Inositol monophosphatase, conserved site GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 Pfam PF00459 Inositol monophosphatase family 15 245 7.2E-52 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS14840 edeb1c0433629cdd85765715d23ca335 275 Gene3D G3DSA:3.30.540.10 16 166 9.8E-35 T 17-03-2017 SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 SMART SM00490 422 499 5.9E-12 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 Pfam PF16203 ERCC3/RAD25/XPB C-terminal helicase 352 543 4.2E-47 T 17-03-2017 IPR032438 ERCC3/RAD25/XPB helicase, C-terminal domain Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167246|Reactome: R-HSA-427413|Reactome: R-HSA-5696395|Reactome: R-HSA-5696400|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73863|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-77075 SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 Pfam PF04851 Type III restriction enzyme, res subunit 181 325 1.7E-11 T 17-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 SUPERFAMILY SSF52540 386 526 3.5E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 SUPERFAMILY SSF52540 286 353 3.5E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 Pfam PF13625 Helicase conserved C-terminal domain 5 133 4.3E-46 T 17-03-2017 IPR032830 Helicase XPB/Ssl2, N-terminal domain Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167246|Reactome: R-HSA-427413|Reactome: R-HSA-5696395|Reactome: R-HSA-5696400|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73863|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-77075 SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 SMART SM00487 177 352 5.8E-20 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 Gene3D G3DSA:3.40.50.300 380 524 2.8E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 Gene3D G3DSA:3.40.50.300 180 342 2.8E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25785 aa764bb18acb31a533849689ba346798 549 SUPERFAMILY SSF52540 135 342 7.8E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 Gene3D G3DSA:3.20.20.150 7 288 7.5E-85 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 ProSitePatterns PS00730 AP endonucleases family 2 signature 2. 180 187 - T 17-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 Pfam PF01261 Xylose isomerase-like TIM barrel 24 244 6.9E-31 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 SUPERFAMILY SSF51658 8 286 3.8E-72 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 SMART SM00518 7 288 1.4E-101 T 17-03-2017 IPR001719 AP endonuclease 2 GO:0003677|GO:0006281|GO:0008270 SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 TIGRFAM TIGR00587 nfo: apurinic endonuclease (APN1) 8 273 9.4E-62 T 17-03-2017 IPR001719 AP endonuclease 2 GO:0003677|GO:0006281|GO:0008270 SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 ProSitePatterns PS00731 AP endonucleases family 2 signature 3. 220 236 - T 17-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 Hamap MF_00152 Probable endonuclease 4 [nfo]. 6 288 38.856 T 17-03-2017 IPR001719 AP endonuclease 2 GO:0003677|GO:0006281|GO:0008270 SHXM_RS18715 7fdac144ddf31f22e8387400e759e847 292 ProSitePatterns PS00729 AP endonucleases family 2 signature 1. 71 79 - T 17-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 SHXM_RS25875 821fc9297fa23896c7ac572a489a9cef 284 Pfam PF02358 Trehalose-phosphatase 32 247 1.0E-26 T 17-03-2017 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 SHXM_RS25875 821fc9297fa23896c7ac572a489a9cef 284 SUPERFAMILY SSF56784 30 275 3.05E-33 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS25875 821fc9297fa23896c7ac572a489a9cef 284 TIGRFAM TIGR00685 T6PP: trehalose-phosphatase 30 275 4.2E-32 T 17-03-2017 IPR003337 Trehalose-phosphatase GO:0003824|GO:0005992 SHXM_RS25875 821fc9297fa23896c7ac572a489a9cef 284 Gene3D G3DSA:3.40.50.1000 188 279 1.5E-33 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS25875 821fc9297fa23896c7ac572a489a9cef 284 Gene3D G3DSA:3.40.50.1000 28 108 1.5E-33 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS03980 aa8aa8fdb5814b734dc8d63725466c70 144 SUPERFAMILY SSF55874 50 138 1.43E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03980 aa8aa8fdb5814b734dc8d63725466c70 144 Pfam PF13581 Histidine kinase-like ATPase domain 26 124 3.9E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03980 aa8aa8fdb5814b734dc8d63725466c70 144 Gene3D G3DSA:3.30.565.10 28 132 4.0E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21815 0a53730fe3a1821531e60b6ba1736414 475 PIRSF PIRSF006060 14 473 4.1E-61 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS21815 0a53730fe3a1821531e60b6ba1736414 475 Pfam PF00324 Amino acid permease 35 468 1.8E-101 T 17-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 SHXM_RS21815 0a53730fe3a1821531e60b6ba1736414 475 ProSitePatterns PS00218 Amino acid permeases signature. 60 90 - T 17-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SHXM_RS21960 2324cba1b954663f4a7a17d6952ad4e8 451 SUPERFAMILY SSF81606 183 441 1.05E-40 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21960 2324cba1b954663f4a7a17d6952ad4e8 451 Gene3D G3DSA:3.60.40.10 183 441 2.0E-48 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21960 2324cba1b954663f4a7a17d6952ad4e8 451 Pfam PF13672 Protein phosphatase 2C 195 405 7.7E-17 T 17-03-2017 SHXM_RS21960 2324cba1b954663f4a7a17d6952ad4e8 451 SMART SM00332 177 439 2.9E-11 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21960 2324cba1b954663f4a7a17d6952ad4e8 451 SMART SM00331 187 441 2.9E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 27 38 1.6E-11 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 11 27 1.6E-11 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 38 57 1.6E-11 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 SUPERFAMILY SSF54909 73 152 4.69E-16 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 SUPERFAMILY SSF46785 10 65 3.12E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 ProSitePatterns PS00519 AsnC-type HTH domain signature. 29 55 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 Pfam PF13404 AsnC-type helix-turn-helix domain 11 51 3.1E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 Gene3D G3DSA:1.10.10.10 10 58 9.1E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 Pfam PF01037 Lrp/AsnC ligand binding domain 76 145 1.1E-16 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 Gene3D G3DSA:3.30.70.920 74 145 1.0E-17 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS36735 83fe56cabbf6c89f007a81681c424cdd 156 SMART SM00344 11 115 9.2E-36 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS18500 e02d7c3dd0ef600b4c0b8d2ef0fbcbb1 384 SUPERFAMILY SSF50182 179 244 3.17E-16 T 17-03-2017 IPR010920 LSM domain SHXM_RS18500 e02d7c3dd0ef600b4c0b8d2ef0fbcbb1 384 Pfam PF00924 Mechanosensitive ion channel 138 329 9.5E-35 T 17-03-2017 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SHXM_RS18500 e02d7c3dd0ef600b4c0b8d2ef0fbcbb1 384 Gene3D G3DSA:3.30.70.100 260 327 7.0E-4 T 17-03-2017 SHXM_RS18500 e02d7c3dd0ef600b4c0b8d2ef0fbcbb1 384 Gene3D G3DSA:2.30.30.60 195 243 2.9E-12 T 17-03-2017 SHXM_RS45435 c1f041aad7bc1fcddfdcab17102a1543 229 SUPERFAMILY SSF53335 24 208 2.59E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45435 c1f041aad7bc1fcddfdcab17102a1543 229 Gene3D G3DSA:3.40.50.150 37 223 7.0E-36 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45435 c1f041aad7bc1fcddfdcab17102a1543 229 Pfam PF13649 Methyltransferase domain 58 151 1.2E-16 T 17-03-2017 SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 SUPERFAMILY SSF46548 122 231 5.58E-18 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 Gene3D G3DSA:3.10.20.30 5 96 5.8E-29 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 Pfam PF13085 2Fe-2S iron-sulfur cluster binding domain 8 106 1.1E-25 T 17-03-2017 IPR025192 Succinate dehydogenase/fumarate reductase N-terminal GO:0009055|GO:0051536 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 Gene3D G3DSA:1.10.1060.10 97 244 3.7E-18 T 17-03-2017 SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 54 62 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 Pfam PF13183 4Fe-4S dicluster domain 141 222 2.0E-14 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 SUPERFAMILY SSF54292 6 104 2.23E-22 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS33815 58b5e116a4bf846b4926d467ec92b95a 256 TIGRFAM TIGR00384 dhsB: succinate dehydrogenase and fumarate reductase iron-sulfur protein 18 225 3.7E-42 T 17-03-2017 IPR004489 Succinate dehydrogenase/fumarate reductase iron-sulphur protein GO:0006099|GO:0016491|GO:0055114 KEGG: 00020+1.3.5.1|KEGG: 00190+1.3.5.1|KEGG: 00650+1.3.5.1|KEGG: 00720+1.3.5.1|MetaCyc: PWY-3781|MetaCyc: PWY-4302|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7279|Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS09175 dcb0717d1836dd53edd6ce7baf7d1884 143 Pfam PF00106 short chain dehydrogenase 9 120 2.2E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09175 dcb0717d1836dd53edd6ce7baf7d1884 143 Gene3D G3DSA:3.40.50.720 2 119 1.1E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09175 dcb0717d1836dd53edd6ce7baf7d1884 143 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 93 104 1.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09175 dcb0717d1836dd53edd6ce7baf7d1884 143 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09175 dcb0717d1836dd53edd6ce7baf7d1884 143 SUPERFAMILY SSF51735 4 117 3.22E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 TIGRFAM TIGR00566 trpG_papA: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase 4 186 5.3E-49 T 17-03-2017 IPR006221 Anthranilate synthase/para-aminobenzoate synthase like domain GO:0008152 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 Gene3D G3DSA:3.40.50.880 2 188 7.6E-64 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 77 93 7.6E-7 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00099 Carbamoyl-phosphate synthase protein GATase domain signature 46 60 7.6E-7 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00096 Glutamine amidotransferase superfamily signature 165 178 1.1E-12 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00096 Glutamine amidotransferase superfamily signature 77 88 1.1E-12 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00096 Glutamine amidotransferase superfamily signature 49 58 1.1E-12 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 Pfam PF00117 Glutamine amidotransferase class-I 5 185 2.6E-43 T 17-03-2017 IPR017926 Glutamine amidotransferase SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00097 Anthranilate synthase component II signature 165 178 2.6E-30 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00097 Anthranilate synthase component II signature 3 17 2.6E-30 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00097 Anthranilate synthase component II signature 77 88 2.6E-30 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00097 Anthranilate synthase component II signature 102 110 2.6E-30 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00097 Anthranilate synthase component II signature 122 134 2.6E-30 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 PRINTS PR00097 Anthranilate synthase component II signature 49 58 2.6E-30 T 17-03-2017 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 SUPERFAMILY SSF56322 227 694 4.19E-128 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 TIGRFAM TIGR00553 pabB: aminodeoxychorismate synthase, component I 332 688 3.2E-116 T 17-03-2017 IPR005802 Para-aminobenzoate synthase, component I GO:0009396 KEGG: 00790+2.6.1.85|MetaCyc: PWY-6543 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 SUPERFAMILY SSF52317 1 187 1.11E-51 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 Gene3D G3DSA:3.60.120.10 226 693 1.0E-144 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 Pfam PF00425 chorismate binding enzyme 430 684 1.7E-88 T 17-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal SHXM_RS16415 5d9a29160e4406db4af7f0d819af3974 708 Pfam PF04715 Anthranilate synthase component I, N terminal region 247 377 7.1E-14 T 17-03-2017 IPR006805 Anthranilate synthase component I, N-terminal GO:0009058|GO:0016833 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Gene3D G3DSA:3.40.50.980 269 427 1.8E-26 T 17-03-2017 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 31 83 1.6E-20 T 17-03-2017 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Gene3D G3DSA:3.30.300.30 522 643 2.0E-30 T 17-03-2017 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 TIGRFAM TIGR02188 Ac_CoA_lig_AcsA: acetate--CoA ligase 26 644 2.0E-293 T 17-03-2017 IPR011904 Acetate-CoA ligase GO:0003987|GO:0016208|GO:0019427 KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118|Reactome: R-HSA-71384 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Gene3D G3DSA:2.30.38.10 443 518 5.3E-6 T 17-03-2017 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Gene3D G3DSA:3.40.50.980 81 268 1.1E-41 T 17-03-2017 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 SUPERFAMILY SSF56801 31 642 5.63E-176 T 17-03-2017 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Hamap MF_01123 Acetyl-coenzyme A synthetase [acs]. 11 646 50.558 T 17-03-2017 IPR011904 Acetate-CoA ligase GO:0003987|GO:0016208|GO:0019427 KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118|Reactome: R-HSA-71384 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 ProSitePatterns PS00455 Putative AMP-binding domain signature. 263 274 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Pfam PF00501 AMP-binding enzyme 92 525 4.6E-90 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS26960 c885da09133392a4c29cbee5be8997d9 653 Pfam PF13193 AMP-binding enzyme C-terminal domain 534 612 2.2E-27 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 ProSitePatterns PS00330 Hemolysin-type calcium-binding region signature. 249 267 - T 17-03-2017 IPR018511 Hemolysin-type calcium-binding conserved site SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Gene3D G3DSA:2.150.10.10 145 276 5.0E-29 T 17-03-2017 IPR011049 Serralysin-like metalloprotease, C-terminal SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 261 276 0.0076 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 145 157 0.18 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 198 215 0.03 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 162 175 13.0 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 217 233 0.035 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 182 190 7.7 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 Pfam PF00353 Haemolysin-type calcium-binding repeat (2 copies) 243 260 5.5E-4 T 17-03-2017 IPR001343 Haemolysin-type calcium-binding repeat GO:0005509 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 SUPERFAMILY SSF51120 144 276 4.19E-21 T 17-03-2017 IPR011049 Serralysin-like metalloprotease, C-terminal SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 PRINTS PR00313 NodO calcium binding signature 143 154 4.8E-10 T 17-03-2017 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 PRINTS PR00313 NodO calcium binding signature 183 191 4.8E-10 T 17-03-2017 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 PRINTS PR00313 NodO calcium binding signature 262 271 4.8E-10 T 17-03-2017 SHXM_RS33025 a37405d63312c6ece31d32feeddad70c 281 PRINTS PR00313 NodO calcium binding signature 253 261 4.8E-10 T 17-03-2017 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 ProSitePatterns PS00049 Ribosomal protein L14 signature. 60 86 - T 17-03-2017 IPR019972 Ribosomal protein L14P, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 Hamap MF_01367 50S ribosomal protein L14 [rplN]. 1 122 27.009 T 17-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 Pfam PF00238 Ribosomal protein L14p/L23e 2 122 7.8E-54 T 17-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 SUPERFAMILY SSF50193 2 122 3.01E-50 T 17-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 SMART SM01374 1 122 1.9E-87 T 17-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 TIGRFAM TIGR01067 rplN_bact: ribosomal protein uL14 1 122 5.1E-57 T 17-03-2017 IPR005745 Ribosomal protein L14P, bacterial-type GO:0003735|GO:0006412|GO:0015934 SHXM_RS31215 3f50ccf8806a6bca0e8002ce123e4350 122 Gene3D G3DSA:2.40.150.20 2 122 2.5E-53 T 17-03-2017 IPR000218 Ribosomal protein L14P GO:0003735|GO:0005840|GO:0006412 SHXM_RS01055 c694455142db21acae591e72699d1c26 314 Pfam PF01370 NAD dependent epimerase/dehydratase family 4 217 3.8E-18 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS01055 c694455142db21acae591e72699d1c26 314 Gene3D G3DSA:3.40.50.720 3 280 9.8E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01055 c694455142db21acae591e72699d1c26 314 SUPERFAMILY SSF51735 1 294 2.64E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25305 702cf04d1aa4e07302cc8f6146c96d41 442 SUPERFAMILY SSF53300 265 427 2.23E-23 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS25305 702cf04d1aa4e07302cc8f6146c96d41 442 Gene3D G3DSA:3.40.50.410 266 385 6.3E-5 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS25305 702cf04d1aa4e07302cc8f6146c96d41 442 Pfam PF05762 VWA domain containing CoxE-like protein 204 423 2.4E-60 T 17-03-2017 IPR008912 Uncharacterised protein family CoxE-like SHXM_RS25305 702cf04d1aa4e07302cc8f6146c96d41 442 SMART SM00327 266 425 0.0021 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 ProSitePatterns PS00708 Prolyl endopeptidase family serine active site. 557 587 - T 17-03-2017 IPR002471 Peptidase S9, serine active site GO:0004252|GO:0006508 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 SUPERFAMILY SSF82171 20 363 1.2E-27 T 17-03-2017 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 Gene3D G3DSA:2.140.10.30 20 431 6.2E-63 T 17-03-2017 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 Pfam PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region 111 389 2.5E-31 T 17-03-2017 IPR002469 Dipeptidylpeptidase IV, N-terminal domain GO:0006508 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 Pfam PF00326 Prolyl oligopeptidase family 516 718 4.4E-47 T 17-03-2017 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 SUPERFAMILY SSF53474 472 718 5.9E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 522 546 1.2E-5 T 17-03-2017 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 580 600 1.2E-5 T 17-03-2017 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 PRINTS PR00862 Prolyl oligopeptidase serine protease (S9A) signature 651 673 1.2E-5 T 17-03-2017 IPR002470 Peptidase S9A, prolyl oligopeptidase GO:0004252|GO:0006508 SHXM_RS33975 e71e03c975602b517f6240f1c04c42e7 720 Gene3D G3DSA:3.40.50.1820 473 717 1.1E-76 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11140 598827f447bd2490e28520274277dc8d 1072 Gene3D G3DSA:3.40.50.300 278 395 3.8E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11140 598827f447bd2490e28520274277dc8d 1072 SUPERFAMILY SSF52540 279 409 8.58E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11140 598827f447bd2490e28520274277dc8d 1072 Gene3D G3DSA:3.80.10.10 828 1044 4.0E-15 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS11140 598827f447bd2490e28520274277dc8d 1072 Pfam PF05729 NACHT domain 281 444 4.3E-28 T 17-03-2017 SHXM_RS11140 598827f447bd2490e28520274277dc8d 1072 SUPERFAMILY SSF52058 828 1049 4.08E-13 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS41075 8d24aaf2a372498e5c3d4aee5070688d 258 SUPERFAMILY SSF48371 20 182 2.0E-14 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS41075 8d24aaf2a372498e5c3d4aee5070688d 258 Gene3D G3DSA:1.25.10.10 20 195 5.2E-14 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS25750 cfbb88575828cd9e19abfb929385a331 344 SUPERFAMILY SSF81345 14 339 2.09E-81 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS25750 cfbb88575828cd9e19abfb929385a331 344 Pfam PF01032 FecCD transport family 30 339 1.3E-91 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS25750 cfbb88575828cd9e19abfb929385a331 344 Gene3D G3DSA:1.10.3470.10 17 341 4.2E-102 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 SUPERFAMILY SSF143865 5 262 1.18E-64 T 17-03-2017 SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 SUPERFAMILY SSF144083 265 327 8.24E-20 T 17-03-2017 SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 Gene3D G3DSA:1.20.58.340 138 252 5.3E-37 T 17-03-2017 SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 Pfam PF01544 CorA-like Mg2+ transporter protein 36 326 8.4E-65 T 17-03-2017 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 Gene3D G3DSA:1.20.58.340 254 330 5.6E-27 T 17-03-2017 SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 TIGRFAM TIGR00383 corA: magnesium and cobalt transport protein CorA 29 330 7.0E-60 T 17-03-2017 IPR004488 Magnesium/cobalt transport protein CorA GO:0006824|GO:0015087|GO:0015095|GO:0015693|GO:0016020 SHXM_RS16075 9d683ae85d98491012561b486dbc13ec 330 Gene3D G3DSA:3.30.460.20 4 137 4.7E-42 T 17-03-2017 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 Gene3D G3DSA:1.10.630.10 13 410 1.9E-113 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 164 179 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 329 344 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 301 328 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 359 370 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 283 294 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 147 163 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 350 359 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 201 223 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00359 B-class P450 signature 100 111 1.3E-54 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00385 P450 superfamily signature 246 263 6.9E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00385 P450 superfamily signature 350 359 6.9E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00385 P450 superfamily signature 283 294 6.9E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 PRINTS PR00385 P450 superfamily signature 359 370 6.9E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 352 361 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 SUPERFAMILY SSF48264 23 410 8.91E-84 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41450 0ab43c959c3a55b5e82c379bb2104834 410 Pfam PF00067 Cytochrome P450 225 379 3.1E-21 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30830 4b02dfcf0b20f20128b62f50939f0541 75 SUPERFAMILY SSF54862 6 68 7.54E-16 T 17-03-2017 SHXM_RS30830 4b02dfcf0b20f20128b62f50939f0541 75 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 51 62 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS30830 4b02dfcf0b20f20128b62f50939f0541 75 Pfam PF12838 4Fe-4S dicluster domain 18 65 2.2E-9 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS30830 4b02dfcf0b20f20128b62f50939f0541 75 Gene3D G3DSA:3.30.70.20 12 68 1.8E-15 T 17-03-2017 SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 2.6E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 2.6E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 2.6E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 250 1.2E-62 T 17-03-2017 SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 Gene3D G3DSA:3.40.50.720 4 250 2.0E-83 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 1.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 1.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 215 235 1.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 1.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 1.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 SUPERFAMILY SSF51735 5 250 3.91E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06200 65e0ce4e834219755548b89653b59a79 253 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 185 1.2E-6 T 17-03-2017 SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 Gene3D G3DSA:3.40.50.720 14 211 2.5E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 SUPERFAMILY SSF51735 11 295 8.0E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 88 99 6.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 6.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 6.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 191 6.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 Pfam PF00106 short chain dehydrogenase 17 214 2.0E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 2.9E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 88 99 2.9E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16770 67f238762dbd3786e973d3e0871e3f62 307 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 172 191 2.9E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05965 6f700bf35ebeccaac235bac446ec5f64 458 Pfam PF07690 Major Facilitator Superfamily 66 383 1.8E-30 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS05965 6f700bf35ebeccaac235bac446ec5f64 458 SUPERFAMILY SSF103473 30 439 3.01E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05965 6f700bf35ebeccaac235bac446ec5f64 458 Gene3D G3DSA:1.20.1250.20 31 241 2.5E-23 T 17-03-2017 SHXM_RS05965 6f700bf35ebeccaac235bac446ec5f64 458 Gene3D G3DSA:1.20.1250.20 255 443 4.4E-19 T 17-03-2017 SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 Hamap MF_00508 30S ribosomal protein S10 [rpsJ]. 3 102 27.897 T 17-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 ProSitePatterns PS00361 Ribosomal protein S10 signature. 29 44 - T 17-03-2017 IPR018268 Ribosomal protein S10, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 PRINTS PR00971 Ribosomal protein S10 family signature 5 18 4.6E-21 T 17-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 PRINTS PR00971 Ribosomal protein S10 family signature 61 75 4.6E-21 T 17-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 PRINTS PR00971 Ribosomal protein S10 family signature 40 55 4.6E-21 T 17-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 Pfam PF00338 Ribosomal protein S10p/S20e 7 101 7.9E-37 T 17-03-2017 IPR027486 Ribosomal protein S10 domain SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 SUPERFAMILY SSF54999 5 102 1.02E-38 T 17-03-2017 IPR027486 Ribosomal protein S10 domain SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 SMART SM01403 7 101 3.5E-59 T 17-03-2017 IPR027486 Ribosomal protein S10 domain SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 Gene3D G3DSA:3.30.70.600 4 102 5.6E-45 T 17-03-2017 IPR027486 Ribosomal protein S10 domain SHXM_RS31160 d35654293dc2e94d70aeab4558b9f5eb 102 TIGRFAM TIGR01049 rpsJ_bact: ribosomal protein uS10 4 101 1.1E-47 T 17-03-2017 IPR001848 Ribosomal protein S10 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72649|Reactome: R-HSA-72689|Reactome: R-HSA-72695|Reactome: R-HSA-72702|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS28030 c3eca7462c2ceb02d8d718ea98c4767e 452 Gene3D G3DSA:1.20.1250.20 16 200 8.8E-7 T 17-03-2017 SHXM_RS28030 c3eca7462c2ceb02d8d718ea98c4767e 452 Gene3D G3DSA:1.20.1250.20 245 438 2.0E-6 T 17-03-2017 SHXM_RS28030 c3eca7462c2ceb02d8d718ea98c4767e 452 SUPERFAMILY SSF103473 17 435 1.96E-22 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 336 345 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 Pfam PF00067 Cytochrome P450 180 379 1.8E-26 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 SUPERFAMILY SSF48264 17 395 1.15E-89 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 147 162 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 313 328 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 285 312 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 84 95 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 343 354 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 268 279 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 334 343 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 187 209 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 PRINTS PR00359 B-class P450 signature 130 146 9.9E-55 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37825 47178ea7c95657ab3855bbca8aa4b405 396 Gene3D G3DSA:1.10.630.10 13 394 3.5E-110 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 Gene3D G3DSA:1.10.10.10 4 61 2.7E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 Gene3D G3DSA:1.20.120.530 64 204 9.6E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 Pfam PF07729 FCD domain 70 192 2.5E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 SUPERFAMILY SSF48008 65 201 3.4E-23 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 SUPERFAMILY SSF46785 4 64 4.87E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 SMART SM00345 3 60 1.3E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 Pfam PF00392 Bacterial regulatory proteins, gntR family 4 56 2.2E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS50325 6e5af4b1215d47cde2a52547d028b795 211 SMART SM00895 70 194 7.3E-15 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 104 122 3.2E-25 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 239 255 3.2E-25 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 8 27 3.2E-25 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 153 171 3.2E-25 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 269 291 3.2E-25 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 SUPERFAMILY SSF51905 4 198 9.5E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 SUPERFAMILY SSF55424 336 430 8.79E-26 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 SUPERFAMILY SSF51905 153 335 4.15E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 Pfam PF14759 Reductase C-terminal 344 430 2.8E-17 T 17-03-2017 IPR028202 Reductase, C-terminal SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 Gene3D G3DSA:3.50.50.60 113 334 4.0E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 Gene3D G3DSA:3.30.390.30 344 430 2.3E-29 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 7 29 4.8E-16 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 153 178 4.8E-16 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 240 254 4.8E-16 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 284 291 4.8E-16 T 17-03-2017 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 Gene3D G3DSA:3.50.50.60 4 112 8.8E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20610 ecfd2dc3193fa0b4cac48db0b4eda230 431 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 8 300 3.0E-63 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 SUPERFAMILY SSF81923 4 157 5.59E-31 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Gene3D G3DSA:1.10.8.60 782 857 1.1E-29 T 17-03-2017 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 ProSitePatterns PS00870 Chaperonins clpA/B signature 1. 296 308 - T 17-03-2017 IPR018368 ClpA/B, conserved site 1 GO:0005524 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 95 146 4.2E-11 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 16 68 5.6E-5 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Gene3D G3DSA:3.40.50.300 558 781 3.0E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Gene3D G3DSA:1.10.1780.10 4 149 1.8E-32 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Gene3D G3DSA:3.40.50.300 160 343 8.2E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 SUPERFAMILY SSF52540 158 551 7.45E-89 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 770 850 1.6E-26 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 TIGRFAM TIGR03346 chaperone_ClpB: ATP-dependent chaperone protein ClpB 5 857 0.0 T 17-03-2017 IPR017730 Chaperonin ClpB GO:0005737|GO:0009408|GO:0016485 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 SUPERFAMILY SSF52540 552 853 6.88E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Gene3D G3DSA:1.10.8.60 345 429 6.9E-35 T 17-03-2017 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 ProSitePatterns PS00871 Chaperonins clpA/B signature 2. 637 655 - T 17-03-2017 IPR028299 ClpA/B, conserved site 2 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 714 728 5.0E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 607 625 5.0E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 652 670 5.0E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 681 699 5.0E-42 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 204 338 2.9E-11 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 SMART SM01086 770 859 1.2E-35 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 SMART SM00382 603 752 6.3E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 SMART SM00382 199 346 4.2E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS29120 03ca75965720d4efdfed9385dd0422e9 863 Pfam PF07724 AAA domain (Cdc48 subfamily) 602 763 4.8E-52 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 SUPERFAMILY SSF89796 367 765 4.45E-113 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Pfam PF02515 CoA-transferase family III 370 741 6.2E-112 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Pfam PF02515 CoA-transferase family III 6 345 3.4E-41 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Gene3D G3DSA:3.30.1540.10 198 283 2.0E-9 T 17-03-2017 SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Gene3D G3DSA:3.30.1540.10 589 672 2.0E-25 T 17-03-2017 SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Gene3D G3DSA:3.40.50.10540 367 588 5.4E-94 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Gene3D G3DSA:3.40.50.10540 673 765 5.4E-94 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Gene3D G3DSA:3.40.50.10540 284 347 2.6E-39 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 Gene3D G3DSA:3.40.50.10540 6 192 2.6E-39 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS45830 d64461add7297f30e649c3426de2e839 766 SUPERFAMILY SSF89796 6 347 2.62E-50 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 SUPERFAMILY SSF50331 245 368 4.42E-16 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 Gene3D G3DSA:3.40.50.300 13 242 4.2E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 ProSitePatterns PS00211 ABC transporters family signature. 142 156 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 Pfam PF08402 TOBE domain 288 368 4.3E-14 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 TIGRFAM TIGR01187 potA: polyamine ABC transporter, ATP-binding protein 44 366 1.6E-110 T 17-03-2017 IPR005893 Spermidine/putrescine ABC transporter, ATP-binding subunit GO:0015417|GO:0015846|GO:0043190 SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 SMART SM00382 38 266 3.5E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 SUPERFAMILY SSF52540 14 251 3.8E-85 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36780 0f7991a73e18ba7766100d7a642d5035 387 Pfam PF00005 ABC transporter 30 169 5.2E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS26260 642f862b53009118afd964b19ab57aff 164 SUPERFAMILY SSF55874 46 134 1.45E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26260 642f862b53009118afd964b19ab57aff 164 Gene3D G3DSA:3.30.565.10 54 134 8.8E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26260 642f862b53009118afd964b19ab57aff 164 Pfam PF13581 Histidine kinase-like ATPase domain 19 130 5.7E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10810 d1f17b0f28e249dfba0822a6fbae163a 230 SMART SM00448 8 121 1.1E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS10810 d1f17b0f28e249dfba0822a6fbae163a 230 PIRSF PIRSF006171 6 230 2.2E-83 T 17-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 SHXM_RS10810 d1f17b0f28e249dfba0822a6fbae163a 230 SUPERFAMILY SSF52172 8 128 1.21E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS10810 d1f17b0f28e249dfba0822a6fbae163a 230 Gene3D G3DSA:3.40.50.2300 5 129 7.6E-31 T 17-03-2017 SHXM_RS10810 d1f17b0f28e249dfba0822a6fbae163a 230 Pfam PF00072 Response regulator receiver domain 10 121 1.5E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS12510 09951f7b96af46f0196c23c9fc4ac462 409 Pfam PF03993 Domain of Unknown Function (DUF349) 91 164 3.2E-10 T 17-03-2017 IPR007139 Protein of unknown function DUF349 SHXM_RS12510 09951f7b96af46f0196c23c9fc4ac462 409 Pfam PF03993 Domain of Unknown Function (DUF349) 245 318 7.0E-21 T 17-03-2017 IPR007139 Protein of unknown function DUF349 SHXM_RS12510 09951f7b96af46f0196c23c9fc4ac462 409 Pfam PF03993 Domain of Unknown Function (DUF349) 168 241 3.2E-21 T 17-03-2017 IPR007139 Protein of unknown function DUF349 SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 69 245 1.5E-8 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 SUPERFAMILY SSF52922 642 786 6.12E-23 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 Gene3D G3DSA:3.40.50.970 414 635 2.5E-67 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 SUPERFAMILY SSF52518 412 627 2.94E-47 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 Gene3D G3DSA:3.40.50.920 648 786 6.8E-33 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 SUPERFAMILY SSF52518 26 388 2.8E-60 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 SMART SM00861 423 627 9.4E-6 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 PIRSF PIRSF000156 22 787 2.4E-68 T 17-03-2017 IPR004660 2-oxo-acid dehydrogenase E1 component homodimeric type GO:0016491|GO:0055114 KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS00360 0dd4cc222a38036c120b1b80e4f08c6f 787 Gene3D G3DSA:3.40.50.970 24 398 1.2E-91 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS02810 75fbfa8efcacbf949fcb4b2122cd4fa1 213 SMART SM00849 7 174 7.5E-5 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02810 75fbfa8efcacbf949fcb4b2122cd4fa1 213 SUPERFAMILY SSF56281 1 179 2.44E-21 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02810 75fbfa8efcacbf949fcb4b2122cd4fa1 213 Pfam PF13483 Beta-lactamase superfamily domain 2 168 3.5E-20 T 17-03-2017 SHXM_RS02810 75fbfa8efcacbf949fcb4b2122cd4fa1 213 Gene3D G3DSA:3.60.15.10 1 210 5.7E-28 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS24535 02934761db6c37caf99003ff9198041d 319 Gene3D G3DSA:3.30.420.150 131 318 2.5E-56 T 17-03-2017 SHXM_RS24535 02934761db6c37caf99003ff9198041d 319 SUPERFAMILY SSF53067 134 318 2.07E-35 T 17-03-2017 SHXM_RS24535 02934761db6c37caf99003ff9198041d 319 SUPERFAMILY SSF53067 3 124 2.63E-32 T 17-03-2017 SHXM_RS24535 02934761db6c37caf99003ff9198041d 319 Gene3D G3DSA:3.30.420.40 1 125 1.5E-48 T 17-03-2017 SHXM_RS24535 02934761db6c37caf99003ff9198041d 319 Pfam PF02541 Ppx/GppA phosphatase family 28 314 6.3E-56 T 17-03-2017 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40 SHXM_RS28320 7e03615d4ddacf66aaa79671f22a2fe6 233 TIGRFAM TIGR02158 PA_CoA_Oxy3: phenylacetate-CoA oxygenase, PaaI subunit 7 233 1.3E-76 T 17-03-2017 IPR011882 1,2-phenylacetyl-CoA epoxidase, subunit C GO:0010124 SHXM_RS28320 7e03615d4ddacf66aaa79671f22a2fe6 233 PIRSF PIRSF037834 1 233 2.2E-89 T 17-03-2017 IPR011882 1,2-phenylacetyl-CoA epoxidase, subunit C GO:0010124 SHXM_RS28320 7e03615d4ddacf66aaa79671f22a2fe6 233 Gene3D G3DSA:1.20.1260.10 4 233 6.9E-80 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS28320 7e03615d4ddacf66aaa79671f22a2fe6 233 Pfam PF05138 Phenylacetic acid catabolic protein 4 233 2.2E-72 T 17-03-2017 IPR007814 1,2-phenylacetyl-CoA epoxidase, subunit A/C GO:0010124 SHXM_RS28320 7e03615d4ddacf66aaa79671f22a2fe6 233 SUPERFAMILY SSF47240 5 227 2.27E-61 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS14790 7f6e901ace0206fdd1c18ef67011f390 287 SUPERFAMILY SSF51735 2 257 9.56E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14790 7f6e901ace0206fdd1c18ef67011f390 287 Pfam PF13460 NAD(P)H-binding 6 185 1.3E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14790 7f6e901ace0206fdd1c18ef67011f390 287 Gene3D G3DSA:3.40.50.720 2 219 8.7E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40890 a73bd5125ab37556bdf30e8bc48910b3 370 Pfam PF02595 Glycerate kinase family 3 366 6.5E-131 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS40890 a73bd5125ab37556bdf30e8bc48910b3 370 Gene3D G3DSA:3.90.1510.10 42 269 4.4E-81 T 17-03-2017 IPR018193 Glycerate kinase, flavodoxin-like domain GO:0008887|GO:0031388 SHXM_RS40890 a73bd5125ab37556bdf30e8bc48910b3 370 PIRSF PIRSF006078 1 369 1.6E-119 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS40890 a73bd5125ab37556bdf30e8bc48910b3 370 TIGRFAM TIGR00045 TIGR00045: glycerate kinase 2 365 1.4E-118 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS40890 a73bd5125ab37556bdf30e8bc48910b3 370 SUPERFAMILY SSF110738 2 365 1.57E-117 T 17-03-2017 IPR004381 Glycerate kinase GO:0008887|GO:0031388 SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Pfam PF04851 Type III restriction enzyme, res subunit 13 211 3.6E-14 T 17-03-2017 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 SUPERFAMILY SSF52540 369 455 3.27E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 SUPERFAMILY SSF52540 36 213 3.27E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 SUPERFAMILY SSF52540 271 327 3.27E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Gene3D G3DSA:3.40.50.300 13 211 1.2E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Pfam PF03457 Helicase associated domain 732 792 2.0E-7 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Pfam PF03457 Helicase associated domain 578 643 5.2E-9 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Pfam PF03457 Helicase associated domain 816 886 3.5E-7 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Pfam PF03457 Helicase associated domain 654 722 5.8E-7 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Gene3D G3DSA:3.40.50.300 290 327 1.5E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 Gene3D G3DSA:3.40.50.300 369 456 1.5E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50980 01ef6e520b1f31f9a5ba1cd60cc5a891 890 SMART SM00487 2 228 1.3E-8 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 Gene3D G3DSA:3.30.450.20 275 325 1.8E-8 T 17-03-2017 SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 Gene3D G3DSA:3.30.450.20 163 239 1.8E-8 T 17-03-2017 SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 SUPERFAMILY SSF55781 413 512 3.02E-6 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 SUPERFAMILY SSF55785 162 253 2.86E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 Gene3D G3DSA:3.30.450.20 48 159 2.1E-18 T 17-03-2017 SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 SMART SM00091 172 237 1.5 T 17-03-2017 IPR000014 PAS domain SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 SMART SM00091 48 116 7.3E-7 T 17-03-2017 IPR000014 PAS domain SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 Pfam PF00989 PAS fold 49 159 1.8E-11 T 17-03-2017 IPR013767 PAS fold GO:0006355 SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 SUPERFAMILY SSF55785 48 156 4.71E-18 T 17-03-2017 IPR000014 PAS domain SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 Gene3D G3DSA:3.30.450.40 343 511 1.9E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS25570 90f88e6dfde2cfc2a91dea193810fa60 516 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 48 169 1.3E-13 T 17-03-2017 IPR000014 PAS domain SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 SUPERFAMILY SSF103473 28 436 1.02E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 Pfam PF00083 Sugar (and other) transporter 36 235 4.0E-19 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 Pfam PF00083 Sugar (and other) transporter 258 441 1.1E-11 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 ProSitePatterns PS00216 Sugar transport proteins signature 1. 311 328 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 ProSitePatterns PS00217 Sugar transport proteins signature 2. 141 166 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 Gene3D G3DSA:1.20.1250.20 29 226 5.7E-23 T 17-03-2017 SHXM_RS41035 6afebf2dde8d1f250d3ae506d78a03c1 442 Gene3D G3DSA:1.20.1250.20 260 439 2.1E-18 T 17-03-2017 SHXM_RS20940 13d707dcb93d11fcf042c55dd1903240 362 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 10 238 2.2E-30 T 17-03-2017 SHXM_RS20940 13d707dcb93d11fcf042c55dd1903240 362 SUPERFAMILY SSF53335 23 60 1.03E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20940 13d707dcb93d11fcf042c55dd1903240 362 SUPERFAMILY SSF53335 88 203 1.03E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20940 13d707dcb93d11fcf042c55dd1903240 362 Gene3D G3DSA:3.40.50.150 19 244 1.2E-53 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20940 13d707dcb93d11fcf042c55dd1903240 362 ProSitePatterns PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 161 176 - T 17-03-2017 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 PRINTS PR01806 Virulence factor MviN signature 382 406 9.9E-16 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 PRINTS PR01806 Virulence factor MviN signature 627 646 9.9E-16 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 PRINTS PR01806 Virulence factor MviN signature 406 427 9.9E-16 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 PRINTS PR01806 Virulence factor MviN signature 683 700 9.9E-16 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 PRINTS PR01806 Virulence factor MviN signature 283 302 9.9E-16 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 PRINTS PR01806 Virulence factor MviN signature 302 318 9.9E-16 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 TIGRFAM TIGR01695 murJ_mviN: murein biosynthesis integral membrane protein MurJ 252 782 2.4E-136 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS28045 aba8e38d10731166616ba98e6bdd4a60 792 Pfam PF03023 MviN-like protein 282 749 5.0E-121 T 17-03-2017 IPR004268 Peptidoglycan biosynthesis protein MurJ SHXM_RS03435 3fd13066590e761d09668a2877d0332f 322 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 114 288 2.2E-53 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS03435 3fd13066590e761d09668a2877d0332f 322 Gene3D G3DSA:3.40.50.720 114 289 3.9E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03435 3fd13066590e761d09668a2877d0332f 322 SUPERFAMILY SSF52283 1 127 8.5E-24 T 17-03-2017 SHXM_RS03435 3fd13066590e761d09668a2877d0332f 322 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 38 315 5.7E-11 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS03435 3fd13066590e761d09668a2877d0332f 322 Gene3D G3DSA:3.40.50.720 5 113 6.8E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03435 3fd13066590e761d09668a2877d0332f 322 SUPERFAMILY SSF51735 108 288 5.08E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16810 eaed6518cc5b609dda69b18697ff553c 290 SUPERFAMILY SSF46689 239 274 7.62E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16810 eaed6518cc5b609dda69b18697ff553c 290 SMART SM00342 185 273 1.6E-14 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS16810 eaed6518cc5b609dda69b18697ff553c 290 Gene3D G3DSA:1.10.10.60 238 274 1.9E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16810 eaed6518cc5b609dda69b18697ff553c 290 Gene3D G3DSA:1.10.10.60 169 224 2.5E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16810 eaed6518cc5b609dda69b18697ff553c 290 Pfam PF12833 Helix-turn-helix domain 191 274 2.3E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS28370 d6ba2e45926726593668db9c4907ab6b 380 Gene3D G3DSA:3.40.50.970 41 364 2.5E-115 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28370 d6ba2e45926726593668db9c4907ab6b 380 SUPERFAMILY SSF52518 44 367 5.0E-93 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS28370 d6ba2e45926726593668db9c4907ab6b 380 Pfam PF00676 Dehydrogenase E1 component 66 326 1.7E-71 T 17-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SHXM_RS28370 d6ba2e45926726593668db9c4907ab6b 380 TIGRFAM TIGR03181 PDH_E1_alph_x: pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit 40 364 1.5E-125 T 17-03-2017 IPR017596 Pyruvate dehydrogenase E1 component subunit alpha/BCKADH E1-alpha KEGG: 00010+1.2.4.1|KEGG: 00020+1.2.4.1|KEGG: 00620+1.2.4.1 SHXM_RS43365 70402fd5f710ffafa75ad55b6ff082b5 684 Pfam PF13185 GAF domain 85 228 1.5E-16 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS43365 70402fd5f710ffafa75ad55b6ff082b5 684 Gene3D G3DSA:3.30.450.40 63 244 1.8E-35 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43365 70402fd5f710ffafa75ad55b6ff082b5 684 SUPERFAMILY SSF55781 69 252 3.49E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43365 70402fd5f710ffafa75ad55b6ff082b5 684 SMART SM00065 86 237 2.3E-18 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS43365 70402fd5f710ffafa75ad55b6ff082b5 684 Pfam PF13556 PucR C-terminal helix-turn-helix domain 617 675 1.4E-16 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS46755 d6afeef4ef328ae5251faf199e9b7c9d 366 Pfam PF00756 Putative esterase 146 363 2.2E-34 T 17-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 SHXM_RS46755 d6afeef4ef328ae5251faf199e9b7c9d 366 SUPERFAMILY SSF81296 21 121 7.35E-20 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS46755 d6afeef4ef328ae5251faf199e9b7c9d 366 SUPERFAMILY SSF53474 132 361 1.13E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46755 d6afeef4ef328ae5251faf199e9b7c9d 366 Gene3D G3DSA:3.40.50.1820 118 365 9.5E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46755 d6afeef4ef328ae5251faf199e9b7c9d 366 Gene3D G3DSA:2.60.40.10 22 102 2.6E-8 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS44345 6bd2ab3e13499b832cd401d1e65a7c87 466 Gene3D G3DSA:1.20.1250.20 12 190 1.9E-26 T 17-03-2017 SHXM_RS44345 6bd2ab3e13499b832cd401d1e65a7c87 466 Gene3D G3DSA:1.20.1250.20 263 445 1.9E-9 T 17-03-2017 SHXM_RS44345 6bd2ab3e13499b832cd401d1e65a7c87 466 Pfam PF07690 Major Facilitator Superfamily 19 404 6.1E-39 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS44345 6bd2ab3e13499b832cd401d1e65a7c87 466 SUPERFAMILY SSF103473 247 444 2.49E-52 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS44345 6bd2ab3e13499b832cd401d1e65a7c87 466 SUPERFAMILY SSF103473 10 195 2.49E-52 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS34675 c00e2027851963f20f424f73330d292b 131 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 6 123 3.4E-14 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS34675 c00e2027851963f20f424f73330d292b 131 SUPERFAMILY SSF54593 1 129 5.1E-25 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS34675 c00e2027851963f20f424f73330d292b 131 Gene3D G3DSA:3.10.180.10 1 129 5.8E-34 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 3.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 3.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 3.6E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 211 5.9E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 SUPERFAMILY SSF52172 1 186 4.84E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 Gene3D G3DSA:1.10.10.10 161 217 5.2E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 SMART SM00448 2 117 8.3E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 Gene3D G3DSA:3.40.50.2300 1 160 1.6E-37 T 17-03-2017 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 Pfam PF00072 Response regulator receiver domain 4 116 3.4E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 SMART SM00421 155 212 2.9E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20915 f8f7ae66a591813098898bde22ab3e70 219 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS23725 d0c36b8f076b6493091489f7101df74b 198 Pfam PF07336 Putative stress-induced transcription regulator 14 145 1.0E-22 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS23725 d0c36b8f076b6493091489f7101df74b 198 SUPERFAMILY SSF160904 9 192 1.57E-42 T 17-03-2017 SHXM_RS23725 d0c36b8f076b6493091489f7101df74b 198 Pfam PF11706 CGNR zinc finger 151 192 4.6E-17 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS23725 d0c36b8f076b6493091489f7101df74b 198 Gene3D G3DSA:1.10.3300.10 10 192 2.4E-46 T 17-03-2017 IPR023286 ABATE domain SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 Gene3D G3DSA:1.10.10.10 2 84 9.0E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 Pfam PF03466 LysR substrate binding domain 88 297 5.2E-32 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 Gene3D G3DSA:3.40.190.10 92 177 8.6E-17 T 17-03-2017 SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 SUPERFAMILY SSF53850 88 300 1.52E-29 T 17-03-2017 SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 4.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 4.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 4.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 62 4.6E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 SUPERFAMILY SSF46785 3 109 1.51E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13655 b765400bceacc3db6d45c29edd8354db 304 Gene3D G3DSA:3.40.190.10 178 265 2.0E-16 T 17-03-2017 SHXM_RS40445 852455a1690c5d3df408056ae946ea93 466 SUPERFAMILY SSF110221 326 464 5.62E-40 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS40445 852455a1690c5d3df408056ae946ea93 466 Gene3D G3DSA:2.80.10.50 325 464 2.7E-37 T 17-03-2017 SHXM_RS40445 852455a1690c5d3df408056ae946ea93 466 Pfam PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain 334 464 1.4E-44 T 17-03-2017 IPR007934 Alpha-L-arabinofuranosidase B, arabinose-binding domain GO:0046373|GO:0046556 SHXM_RS40445 852455a1690c5d3df408056ae946ea93 466 SUPERFAMILY SSF75005 34 223 1.26E-15 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 Gene3D G3DSA:3.30.9.10 1 139 1.2E-41 T 17-03-2017 SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 Pfam PF01494 FAD binding domain 1 179 1.8E-26 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 SUPERFAMILY SSF54373 21 115 1.41E-23 T 17-03-2017 SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 SUPERFAMILY SSF51905 2 18 1.43E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 SUPERFAMILY SSF51905 105 194 1.43E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 118 133 3.0E-5 T 17-03-2017 SHXM_RS46835 a1dc45daa3d20f6b14cdacb261481370 232 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 133 149 3.0E-5 T 17-03-2017 SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Hamap MF_00420 Phosphoribosylformylglycinamidine synthase subunit PurL [purL]. 1 749 311.49 T 17-03-2017 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 TIGRFAM TIGR01736 FGAM_synth_II: phosphoribosylformylglycinamidine synthase II 24 745 1.5E-262 T 17-03-2017 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Pfam PF02769 AIR synthase related protein, C-terminal domain 211 366 1.7E-33 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Pfam PF02769 AIR synthase related protein, C-terminal domain 585 721 3.0E-21 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 PIRSF PIRSF001587 4 749 6.2E-291 T 17-03-2017 IPR010074 Phosphoribosylformylglycinamidine subunit PurL GO:0004642|GO:0005737|GO:0006189 KEGG: 00230+6.3.5.3|MetaCyc: PWY-6121|MetaCyc: PWY-6122|MetaCyc: PWY-6277 SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 SUPERFAMILY SSF56042 583 748 6.73E-40 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Pfam PF00586 AIR synthase related protein, N-terminal domain 96 198 9.5E-23 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Pfam PF00586 AIR synthase related protein, N-terminal domain 468 572 1.7E-21 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 SUPERFAMILY SSF55326 19 204 5.53E-50 T 17-03-2017 SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 SUPERFAMILY SSF55326 408 578 2.09E-54 T 17-03-2017 SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 SUPERFAMILY SSF56042 209 439 2.39E-53 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Gene3D G3DSA:3.90.650.10 261 364 3.9E-4 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Gene3D G3DSA:3.30.1330.10 56 203 2.8E-53 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS29395 2aded1921a78b8704958d4ca1a40caff 749 Gene3D G3DSA:3.30.1330.10 427 575 4.8E-51 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS37775 7ee4fb719f346f6b0bbbbbf9a80d34e3 91 Pfam PF00550 Phosphopantetheine attachment site 17 77 5.4E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37775 7ee4fb719f346f6b0bbbbbf9a80d34e3 91 SUPERFAMILY SSF47336 17 88 3.8E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37775 7ee4fb719f346f6b0bbbbbf9a80d34e3 91 Gene3D G3DSA:1.10.1200.10 17 88 1.3E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42110 a69b60daf6222f4d5ba3982ca77b445d 141 SUPERFAMILY SSF143744 8 140 8.37E-35 T 17-03-2017 SHXM_RS42110 a69b60daf6222f4d5ba3982ca77b445d 141 Pfam PF03928 Haem-degrading 11 137 2.8E-30 T 17-03-2017 IPR005624 Haem-degrading SHXM_RS34970 0d2b1b5aebd927657a7c0091686497c3 428 Pfam PF07690 Major Facilitator Superfamily 34 365 8.8E-32 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS34970 0d2b1b5aebd927657a7c0091686497c3 428 Gene3D G3DSA:1.20.1250.20 22 207 9.6E-25 T 17-03-2017 SHXM_RS34970 0d2b1b5aebd927657a7c0091686497c3 428 SUPERFAMILY SSF103473 17 399 1.57E-54 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS34970 0d2b1b5aebd927657a7c0091686497c3 428 Gene3D G3DSA:1.20.1250.20 222 398 1.1E-16 T 17-03-2017 SHXM_RS00845 7b444e78da329b1f003b0ef76f29bf35 151 Gene3D G3DSA:3.40.930.10 1 150 2.2E-43 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS00845 7b444e78da329b1f003b0ef76f29bf35 151 SUPERFAMILY SSF55804 1 147 1.57E-32 T 17-03-2017 IPR016152 Phosphotransferase/anion transporter GO:0005215|GO:0006810 Reactome: R-HSA-425381 SHXM_RS00845 7b444e78da329b1f003b0ef76f29bf35 151 Pfam PF00359 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 5 146 1.4E-28 T 17-03-2017 IPR002178 PTS EIIA type-2 domain SHXM_RS14190 e3591248aa076cb7d22dd9b7434f02fc 335 Gene3D G3DSA:3.20.20.150 2 315 3.7E-73 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14190 e3591248aa076cb7d22dd9b7434f02fc 335 Pfam PF01261 Xylose isomerase-like TIM barrel 22 272 7.0E-35 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14190 e3591248aa076cb7d22dd9b7434f02fc 335 Pfam PF07582 AP endonuclease family 2 C terminus 275 329 6.4E-24 T 17-03-2017 IPR011418 AP endonuclease, family 2, C-terminal SHXM_RS14190 e3591248aa076cb7d22dd9b7434f02fc 335 SUPERFAMILY SSF51658 8 316 2.09E-54 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS15320 8663c4a51aec9cc2b9e875f66964cd7d 285 Gene3D G3DSA:3.90.850.10 63 281 3.6E-61 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS15320 8663c4a51aec9cc2b9e875f66964cd7d 285 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 77 278 4.2E-49 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS15320 8663c4a51aec9cc2b9e875f66964cd7d 285 SUPERFAMILY SSF56529 71 280 7.46E-56 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 Pfam PF13483 Beta-lactamase superfamily domain 3 106 2.6E-7 T 17-03-2017 SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 SUPERFAMILY SSF56281 1 76 4.76E-15 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 SUPERFAMILY SSF56281 105 228 4.76E-15 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 Pfam PF00355 Rieske [2Fe-2S] domain 460 500 4.4E-8 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 Gene3D G3DSA:3.60.15.10 1 218 3.7E-12 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 SUPERFAMILY SSF50022 460 505 1.03E-11 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS03625 602c988ff132341568fa7ec03fd2cef8 512 Gene3D G3DSA:2.102.10.10 460 508 1.1E-11 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 Pfam PF12848 ABC transporter 227 305 6.8E-12 T 17-03-2017 IPR032781 ABC-transporter extension domain SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 SUPERFAMILY SSF52540 13 240 5.17E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 SMART SM00382 30 239 1.8E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 SMART SM00382 346 516 3.2E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 Gene3D G3DSA:3.40.50.300 138 283 5.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 Gene3D G3DSA:3.40.50.300 8 105 5.3E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 SUPERFAMILY SSF52540 306 514 1.08E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 ProSitePatterns PS00211 ABC transporters family signature. 443 457 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 TIGRFAM TIGR03719 ABC_ABC_ChvD: ATP-binding cassette protein, ChvD family 3 551 7.1E-274 T 17-03-2017 IPR022374 ABC transporter, ATP-binding protein, ChvD SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 ProSitePatterns PS00211 ABC transporters family signature. 160 174 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 Pfam PF00005 ABC transporter 21 188 3.6E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 Pfam PF00005 ABC transporter 338 471 3.0E-20 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22000 7560bfdec3fed4577a96ca8da19c649e 554 Gene3D G3DSA:3.40.50.300 320 528 2.0E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28665 fb8218dea4f4f878d49bf2cf0eb77bd3 237 Gene3D G3DSA:1.20.1260.10 50 233 4.8E-57 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS28665 fb8218dea4f4f878d49bf2cf0eb77bd3 237 Pfam PF03713 Domain of unknown function (DUF305) 57 230 6.2E-42 T 17-03-2017 IPR005183 Domain of unknown function DUF305 SHXM_RS34415 f9268207f9999fa88d6e3831ad40ba68 130 SUPERFAMILY SSF54631 1 122 2.02E-29 T 17-03-2017 SHXM_RS34415 f9268207f9999fa88d6e3831ad40ba68 130 Gene3D G3DSA:3.10.580.10 1 121 3.3E-30 T 17-03-2017 SHXM_RS34415 f9268207f9999fa88d6e3831ad40ba68 130 Pfam PF00571 CBS domain 73 120 3.2E-11 T 17-03-2017 IPR000644 CBS domain SHXM_RS34415 f9268207f9999fa88d6e3831ad40ba68 130 Pfam PF00571 CBS domain 3 55 5.8E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS34415 f9268207f9999fa88d6e3831ad40ba68 130 SMART SM00116 10 58 0.075 T 17-03-2017 IPR000644 CBS domain SHXM_RS34415 f9268207f9999fa88d6e3831ad40ba68 130 SMART SM00116 75 122 3.4E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS00140 6bf0dba8bf29abd4bdcf43d9d17491ab 341 Pfam PF01381 Helix-turn-helix 11 64 5.3E-12 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS00140 6bf0dba8bf29abd4bdcf43d9d17491ab 341 SMART SM00530 10 65 9.6E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS00140 6bf0dba8bf29abd4bdcf43d9d17491ab 341 Gene3D G3DSA:1.10.260.40 9 65 2.9E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00140 6bf0dba8bf29abd4bdcf43d9d17491ab 341 SUPERFAMILY SSF47413 7 72 1.28E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00140 6bf0dba8bf29abd4bdcf43d9d17491ab 341 Pfam PF06114 Domain of unknown function (DUF955) 157 271 1.1E-18 T 17-03-2017 IPR010359 HTH domain, IrrE-type SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 Gene3D G3DSA:1.10.630.10 36 421 7.5E-118 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 362 371 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 158 174 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 212 234 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 293 304 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 311 338 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 369 380 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 339 354 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 175 190 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 111 122 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00359 B-class P450 signature 360 369 1.6E-47 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 SUPERFAMILY SSF48264 32 421 1.96E-92 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00385 P450 superfamily signature 258 275 3.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00385 P450 superfamily signature 360 369 3.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00385 P450 superfamily signature 369 380 3.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 PRINTS PR00385 P450 superfamily signature 293 304 3.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05280 ad31c8d0cca3182f39997db79a76cb4b 423 Pfam PF00067 Cytochrome P450 226 390 7.9E-25 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 PIRSF PIRSF001338 1 164 5.9E-69 T 17-03-2017 IPR024694 PurE, prokaryotic type GO:0006189 KEGG: 00230+5.4.99.18|MetaCyc: PWY-6123|MetaCyc: PWY-7234 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 TIGRFAM TIGR01162 purE: phosphoribosylaminoimidazole carboxylase, catalytic subunit 6 160 2.2E-64 T 17-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 SUPERFAMILY SSF52255 5 162 8.24E-66 T 17-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 Pfam PF00731 AIR carboxylase 6 150 7.0E-66 T 17-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 Gene3D G3DSA:3.40.50.7700 2 161 8.7E-74 T 17-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 SMART SM01001 4 153 8.3E-98 T 17-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 SHXM_RS24310 0ad1d5f90cb52db9bf54fd9dbd21cefd 174 Hamap MF_01929 N5-carboxyaminoimidazole ribonucleotide mutase [purE]. 6 157 32.534 T 17-03-2017 IPR000031 PurE domain GO:0006189 Reactome: R-HSA-73817 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 SUPERFAMILY SSF48179 158 292 1.43E-41 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 1 15 5.9E-35 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 103 128 5.9E-35 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 50 79 5.9E-35 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 149 177 5.9E-35 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 PRINTS PR00076 6-phosphogluconate dehydrogenase signature 224 251 5.9E-35 T 17-03-2017 IPR006183 6-phosphogluconate dehydrogenase GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 SUPERFAMILY SSF51735 1 143 3.52E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 SMART SM01350 160 293 9.4E-7 T 17-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 Pfam PF00393 6-phosphogluconate dehydrogenase, C-terminal domain 160 270 2.8E-26 T 17-03-2017 IPR006114 6-phosphogluconate dehydrogenase, C-terminal GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 ProSitePatterns PS00461 6-phosphogluconate dehydrogenase signature. 228 240 - T 17-03-2017 IPR006184 6-phosphogluconate-binding site GO:0004616|GO:0006098|GO:0055114 KEGG: 00030+1.1.1.44|KEGG: 00480+1.1.1.44|Reactome: R-HSA-71336 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 Gene3D G3DSA:3.40.50.720 1 161 1.3E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 Gene3D G3DSA:1.10.1040.10 162 270 4.5E-36 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 TIGRFAM TIGR00872 gnd_rel: 6-phosphogluconate dehydrogenase (decarboxylating) 1 291 8.1E-103 T 17-03-2017 IPR004849 6-phosphogluconate dehydrogenase, YqeC-type GO:0055114 SHXM_RS28135 57fd726b06e9dca06b263409986ba457 293 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 3 143 3.5E-36 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS09405 5676713db67a30e5205489d5868f841b 69 Pfam PF01609 Transposase DDE domain 3 68 4.0E-9 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS08155 ad86feb6c32cb4fce528de23362d9dc6 311 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 84 238 3.6E-16 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08155 ad86feb6c32cb4fce528de23362d9dc6 311 Pfam PF04542 Sigma-70 region 2 85 148 1.7E-9 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08155 ad86feb6c32cb4fce528de23362d9dc6 311 Gene3D G3DSA:1.10.10.10 177 238 3.5E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08155 ad86feb6c32cb4fce528de23362d9dc6 311 SUPERFAMILY SSF88659 164 241 8.97E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08155 ad86feb6c32cb4fce528de23362d9dc6 311 Gene3D G3DSA:1.10.1740.10 61 174 1.1E-12 T 17-03-2017 SHXM_RS08155 ad86feb6c32cb4fce528de23362d9dc6 311 SUPERFAMILY SSF88946 61 161 1.45E-13 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS04810 85715bf8614f84682933002078865ec4 200 SUPERFAMILY SSF46689 7 80 7.18E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04810 85715bf8614f84682933002078865ec4 200 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 1.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04810 85715bf8614f84682933002078865ec4 200 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 1.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04810 85715bf8614f84682933002078865ec4 200 Gene3D G3DSA:1.10.10.60 7 61 5.5E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04810 85715bf8614f84682933002078865ec4 200 Gene3D G3DSA:1.10.357.10 62 163 7.4E-16 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04810 85715bf8614f84682933002078865ec4 200 ProSitePatterns PS01081 TetR-type HTH domain signature. 32 63 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS04810 85715bf8614f84682933002078865ec4 200 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 63 5.1E-16 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS10720 b3633ece2f4c71667aeccfc2cc897b44 433 SUPERFAMILY SSF103473 19 428 5.23E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS10720 b3633ece2f4c71667aeccfc2cc897b44 433 Pfam PF07690 Major Facilitator Superfamily 266 427 6.9E-11 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS10720 b3633ece2f4c71667aeccfc2cc897b44 433 Pfam PF00083 Sugar (and other) transporter 29 228 1.1E-24 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS10720 b3633ece2f4c71667aeccfc2cc897b44 433 Gene3D G3DSA:1.20.1250.20 23 229 4.2E-23 T 17-03-2017 SHXM_RS10720 b3633ece2f4c71667aeccfc2cc897b44 433 Gene3D G3DSA:1.20.1250.20 252 430 7.4E-16 T 17-03-2017 SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 Gene3D G3DSA:3.40.50.720 4 251 1.4E-79 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 2.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 86 97 2.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 2.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 SUPERFAMILY SSF51735 7 251 6.2E-79 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 147 175 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 250 1.9E-62 T 17-03-2017 SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 2.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 2.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 86 97 2.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 2.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 2.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10665 068c6eb26701b6fa7e9582300c9de053 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 2.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 Gene3D G3DSA:3.40.50.720 26 163 4.1E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 Gene3D G3DSA:3.30.360.10 164 241 1.0E-30 T 17-03-2017 SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 Gene3D G3DSA:3.30.360.10 310 439 1.0E-30 T 17-03-2017 SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 SUPERFAMILY SSF55347 300 381 4.58E-26 T 17-03-2017 SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 SUPERFAMILY SSF55347 156 242 4.58E-26 T 17-03-2017 SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 SUPERFAMILY SSF51735 16 178 6.27E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 163 245 3.4E-7 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS48355 b7fa26830ed19c4767094f9c4bb4ea92 443 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 30 149 8.4E-18 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS39825 cbf1cca2cff799bf71b42a0bb217dbbf 195 SUPERFAMILY SSF52218 6 184 1.22E-42 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS39825 cbf1cca2cff799bf71b42a0bb217dbbf 195 Pfam PF03358 NADPH-dependent FMN reductase 6 124 2.1E-11 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS39825 cbf1cca2cff799bf71b42a0bb217dbbf 195 Gene3D G3DSA:3.40.50.360 1 184 1.7E-56 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS25090 1e5548357005041fdbf27960b5d29c68 356 Pfam PF14219 Domain of unknown function (DUF4328) 112 286 2.9E-48 T 17-03-2017 IPR025565 Domain of unknown function DUF4328 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 SUPERFAMILY SSF48256 9 250 1.02E-52 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 PRINTS PR00143 Citrate synthase signature 220 234 2.8E-6 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 PRINTS PR00143 Citrate synthase signature 200 216 2.8E-6 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 PRINTS PR00143 Citrate synthase signature 141 161 2.8E-6 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 PRINTS PR00143 Citrate synthase signature 58 73 2.8E-6 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 PRINTS PR00143 Citrate synthase signature 80 108 2.8E-6 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 Gene3D G3DSA:1.10.580.10 11 55 1.6E-9 T 17-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 Gene3D G3DSA:1.10.230.10 116 213 4.9E-13 T 17-03-2017 IPR016143 Citrate synthase-like, small alpha subdomain Reactome: R-HSA-163765|Reactome: R-HSA-75105 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 Gene3D G3DSA:1.10.580.10 57 115 9.1E-12 T 17-03-2017 IPR016142 Citrate synthase-like, large alpha subdomain Reactome: R-HSA-1268020|Reactome: R-HSA-71403 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 Pfam PF00285 Citrate synthase, C-terminal domain 55 246 1.1E-29 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS19645 3bff92a0137171edf21338fdbde2e271 288 Pfam PF00285 Citrate synthase, C-terminal domain 11 55 4.3E-7 T 17-03-2017 IPR002020 Citrate synthase GO:0046912 SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 PRINTS PR00400 Tetracycline repressor protein signature 49 72 2.0E-5 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 PRINTS PR00400 Tetracycline repressor protein signature 224 238 2.0E-5 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 Pfam PF00440 Bacterial regulatory proteins, tetR family 37 81 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 SUPERFAMILY SSF46689 25 91 1.94E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 Gene3D G3DSA:1.10.357.10 25 239 1.1E-54 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 SUPERFAMILY SSF48498 103 241 3.28E-25 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11255 c6e71985691a9b395ace7965875a98a4 244 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 94 241 6.1E-19 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 SUPERFAMILY SSF103473 4 196 9.55E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 SUPERFAMILY SSF103473 469 493 9.55E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 SUPERFAMILY SSF103473 248 419 9.55E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 Pfam PF07690 Major Facilitator Superfamily 15 409 1.9E-39 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 Gene3D G3DSA:1.20.1250.20 25 189 1.4E-24 T 17-03-2017 SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 Gene3D G3DSA:1.20.1250.20 476 489 1.1E-13 T 17-03-2017 SHXM_RS46530 63a5e54f0f247dad97ac8e34df2dce58 518 Gene3D G3DSA:1.20.1250.20 258 420 1.1E-13 T 17-03-2017 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 Gene3D G3DSA:3.10.170.10 232 386 4.2E-44 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 385 559 4.8E-56 T 17-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 461 477 2.4E-17 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 373 389 2.4E-17 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 337 357 2.4E-17 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 394 405 2.4E-17 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 SUPERFAMILY SSF55486 231 559 1.14E-79 T 17-03-2017 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 93 134 2.1E-14 T 17-03-2017 IPR011096 FTP domain SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 Gene3D G3DSA:1.10.390.10 387 559 2.3E-55 T 17-03-2017 SHXM_RS35790 cc251c0ae65ccb83e441fc95548705f9 560 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 234 382 2.2E-46 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 1.0E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 1.0E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 1.0E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 SUPERFAMILY SSF53850 89 296 2.48E-36 T 17-03-2017 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 Pfam PF03466 LysR substrate binding domain 89 290 2.4E-38 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 Gene3D G3DSA:1.10.10.10 2 83 4.9E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 SUPERFAMILY SSF46785 1 84 7.31E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 Gene3D G3DSA:3.40.190.10 174 267 2.3E-16 T 17-03-2017 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 61 1.0E-23 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS05515 2a8dc470a6ab9a2de7ab7d5b14f9c7ae 317 Gene3D G3DSA:3.40.190.10 90 173 1.2E-10 T 17-03-2017 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 SUPERFAMILY SSF48264 15 397 1.11E-90 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 346 357 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 135 151 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 288 315 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 337 346 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 152 167 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 270 281 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 189 211 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00359 B-class P450 signature 88 99 7.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 Pfam PF00067 Cytochrome P450 204 367 1.9E-26 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00385 P450 superfamily signature 346 357 2.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00385 P450 superfamily signature 270 281 2.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00385 P450 superfamily signature 235 252 2.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 PRINTS PR00385 P450 superfamily signature 337 346 2.2E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 339 348 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS42795 187e18601c8de608607e7098b0565c9a 397 Gene3D G3DSA:1.10.630.10 13 397 1.9E-116 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS29870 ed9241d5a01c41fa26249c5cee378918 468 Gene3D G3DSA:3.40.50.300 73 159 1.4E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29870 ed9241d5a01c41fa26249c5cee378918 468 Gene3D G3DSA:3.40.50.300 245 375 1.4E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29870 ed9241d5a01c41fa26249c5cee378918 468 Pfam PF12846 AAA-like domain 69 349 3.2E-13 T 17-03-2017 SHXM_RS29870 ed9241d5a01c41fa26249c5cee378918 468 SUPERFAMILY SSF52540 40 424 8.59E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00145 e2897199f468d46a15a868816a2bd7fc 196 Pfam PF13358 DDE superfamily endonuclease 7 142 1.6E-24 T 17-03-2017 SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 SUPERFAMILY SSF56436 181 441 2.83E-77 T 17-03-2017 IPR016187 C-type lectin fold SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 Pfam PF03781 Sulfatase-modifying factor enzyme 1 180 439 7.4E-67 T 17-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 SUPERFAMILY SSF109854 22 149 1.79E-20 T 17-03-2017 SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 TIGRFAM TIGR03440 egtB_TIGR03440: ergothioneine biosynthesis protein EgtB 22 438 3.5E-140 T 17-03-2017 IPR017806 Ergothioneine biosynthesis protein EgtB GO:0052699 KEGG: 00340+1.14.99.50|MetaCyc: PWY-7255 SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 Pfam PF12867 DinB superfamily 22 153 7.4E-28 T 17-03-2017 IPR024775 DinB-like domain SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 Hamap MF_02035 Hercynine oxygenase [egtB]. 1 441 53.053 T 17-03-2017 IPR032890 Hercynine oxygenase, Actinobacteria GO:0016491|GO:0052699 KEGG: 00340+1.14.99.50|MetaCyc: PWY-7255 SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 Gene3D G3DSA:3.90.1580.10 170 441 5.2E-78 T 17-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 SHXM_RS45020 2f498343bbfd4ed3fcf922e258212d67 442 Gene3D G3DSA:1.20.120.450 22 126 1.8E-7 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS32180 4006160038c9f7340a226deced953b65 208 Pfam PF13700 Domain of unknown function (DUF4158) 6 173 6.1E-51 T 17-03-2017 IPR025296 Domain of unknown function DUF4158 SHXM_RS19895 26333e133b24acbd2cc3c41a5bfae4bf 108 Pfam PF03992 Antibiotic biosynthesis monooxygenase 3 75 1.6E-16 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS19895 26333e133b24acbd2cc3c41a5bfae4bf 108 SUPERFAMILY SSF54909 1 101 2.65E-25 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS19895 26333e133b24acbd2cc3c41a5bfae4bf 108 Gene3D G3DSA:3.30.70.900 1 105 4.0E-37 T 17-03-2017 SHXM_RS35350 e0ff96befd84569b1d3f8e3d03cccd74 414 SUPERFAMILY SSF52540 2 220 1.58E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35350 e0ff96befd84569b1d3f8e3d03cccd74 414 Gene3D G3DSA:3.40.50.300 1 221 4.1E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35350 e0ff96befd84569b1d3f8e3d03cccd74 414 Pfam PF00005 ABC transporter 19 156 2.1E-23 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS35350 e0ff96befd84569b1d3f8e3d03cccd74 414 SMART SM00382 26 204 3.1E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS10730 ef9cacc2d98be08e030a3fa2cca10b7d 342 SUPERFAMILY SSF56112 11 317 5.83E-57 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS10730 ef9cacc2d98be08e030a3fa2cca10b7d 342 Gene3D G3DSA:3.90.1200.10 113 300 2.5E-36 T 17-03-2017 SHXM_RS10730 ef9cacc2d98be08e030a3fa2cca10b7d 342 Pfam PF01636 Phosphotransferase enzyme family 33 260 3.9E-48 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 SUPERFAMILY SSF55347 143 302 5.72E-28 T 17-03-2017 SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 SUPERFAMILY SSF51735 5 169 7.75E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 Gene3D G3DSA:3.30.360.10 345 395 1.0E-35 T 17-03-2017 SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 Gene3D G3DSA:3.30.360.10 157 295 1.0E-35 T 17-03-2017 SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 153 234 3.6E-5 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 Gene3D G3DSA:3.40.50.720 5 156 1.7E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46690 32512fb81b39a89b52127f792cf2f1f1 401 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 12 138 2.8E-25 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS33755 d5ff4f2caeca03860b67b64394ecc0a8 186 Gene3D G3DSA:3.90.1570.10 4 154 9.3E-18 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS33755 d5ff4f2caeca03860b67b64394ecc0a8 186 SUPERFAMILY SSF52980 11 155 2.95E-19 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS33755 d5ff4f2caeca03860b67b64394ecc0a8 186 Pfam PF05685 Putative restriction endonuclease 12 166 1.1E-26 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 Gene3D G3DSA:3.30.390.30 328 458 7.2E-28 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 Gene3D G3DSA:3.50.50.60 9 137 1.1E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 135 153 3.1E-35 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 174 192 3.1E-35 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 258 274 3.1E-35 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 11 30 3.1E-35 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 286 308 3.1E-35 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 259 273 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 42 57 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 301 308 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 10 32 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 174 199 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 424 444 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 138 147 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 337 358 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 402 417 3.3E-65 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 SUPERFAMILY SSF51905 7 366 3.2E-60 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 SUPERFAMILY SSF55424 338 459 1.49E-28 T 17-03-2017 IPR016156 FAD/NAD-linked reductase, dimerisation domain GO:0016491|GO:0050660|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 PIRSF PIRSF000350 1 438 3.5E-70 T 17-03-2017 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 341 449 2.1E-23 T 17-03-2017 IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0045454|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 9 321 2.1E-69 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 ProSitePatterns PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 43 53 - T 17-03-2017 IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site GO:0016668|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 Gene3D G3DSA:3.50.50.60 138 327 2.0E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19010 0af4fe3536eb027a56b9afa1b36af1fa 462 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 9 459 1.7E-139 T 17-03-2017 IPR006258 Dihydrolipoamide dehydrogenase GO:0004148|GO:0050660|GO:0055114 KEGG: 00010+1.8.1.4|KEGG: 00020+1.8.1.4|KEGG: 00260+1.8.1.4|KEGG: 00280+1.8.1.4|KEGG: 00620+1.8.1.4|KEGG: 00640+1.8.1.4|MetaCyc: PWY-5046|MetaCyc: PWY-5084|Reactome: R-HSA-204174|Reactome: R-HSA-389661|Reactome: R-HSA-5362517|Reactome: R-HSA-6783984|Reactome: R-HSA-70268|Reactome: R-HSA-70895|Reactome: R-HSA-71064|Reactome: R-HSA-71403 SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 Pfam PF13419 Haloacid dehalogenase-like hydrolase 13 209 1.1E-12 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 Gene3D G3DSA:3.40.50.1000 6 24 2.6E-33 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 Gene3D G3DSA:3.40.50.1000 119 243 2.6E-33 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 107 212 6.9E-11 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 TIGRFAM TIGR02009 PGMB-YQAB-SF: beta-phosphoglucomutase family hydrolase 10 215 5.6E-48 T 17-03-2017 IPR010976 Beta-phosphoglucomutase hydrolase SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 Gene3D G3DSA:1.10.150.240 25 104 4.7E-6 T 17-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 161 177 8.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 128 141 8.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 10 21 8.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS46225 d5528d815a9376e2a8386b714193f6ef 247 SUPERFAMILY SSF56784 10 244 1.23E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 Gene3D G3DSA:3.30.70.360 199 356 2.6E-35 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 Pfam PF01546 Peptidase family M20/M25/M40 86 437 1.5E-36 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 Pfam PF07687 Peptidase dimerisation domain 205 347 2.6E-13 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 Gene3D G3DSA:3.40.630.10 360 445 7.3E-61 T 17-03-2017 SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 Gene3D G3DSA:3.40.630.10 7 193 7.3E-61 T 17-03-2017 SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 SUPERFAMILY SSF53187 7 199 7.71E-55 T 17-03-2017 SHXM_RS43200 a2e0b48c3cdbe0be2114eef95ae0386e 453 SUPERFAMILY SSF53187 361 444 7.71E-55 T 17-03-2017 SHXM_RS40610 10956fa45123b53f1b41d44a55a6820f 668 Gene3D G3DSA:3.40.50.2300 124 172 8.6E-10 T 17-03-2017 SHXM_RS40610 10956fa45123b53f1b41d44a55a6820f 668 Pfam PF00072 Response regulator receiver domain 125 169 2.9E-7 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS40610 10956fa45123b53f1b41d44a55a6820f 668 SUPERFAMILY SSF52172 126 170 4.55E-9 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS40610 10956fa45123b53f1b41d44a55a6820f 668 Gene3D G3DSA:3.20.20.80 320 664 4.7E-124 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS40610 10956fa45123b53f1b41d44a55a6820f 668 SUPERFAMILY SSF51445 332 666 4.01E-81 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS40610 10956fa45123b53f1b41d44a55a6820f 668 Pfam PF07745 Glycosyl hydrolase family 53 335 663 4.8E-105 T 17-03-2017 IPR011683 Glycosyl hydrolase family 53 GO:0015926 SHXM_RS47405 d607e666dcd08f74c288dc96220236a4 222 Pfam PF01323 DSBA-like thioredoxin domain 9 210 4.7E-43 T 17-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 SHXM_RS47405 d607e666dcd08f74c288dc96220236a4 222 SUPERFAMILY SSF52833 6 216 8.06E-42 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS47405 d607e666dcd08f74c288dc96220236a4 222 Gene3D G3DSA:3.40.30.10 5 212 3.4E-49 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 65 338 1.1E-56 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 SUPERFAMILY SSF49785 424 616 3.4E-32 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 365 611 1.5E-41 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 SUPERFAMILY SSF53474 41 376 8.12E-68 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 SMART SM00939 353 620 2.7E-45 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 Gene3D G3DSA:3.40.50.1820 50 223 7.5E-90 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13490 07c8ff701db36eb54eaa72dc216bcf9a 668 Gene3D G3DSA:3.40.50.1820 285 428 7.5E-90 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 261 375 7.2E-31 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 TIGRFAM TIGR03150 fabF: beta-ketoacyl-acyl-carrier-protein synthase II 6 419 3.1E-150 T 17-03-2017 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 Gene3D G3DSA:3.40.47.10 10 264 5.5E-71 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 SUPERFAMILY SSF53901 6 258 6.01E-71 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 6 253 5.4E-57 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 PIRSF PIRSF000447 3 421 1.3E-144 T 17-03-2017 IPR017568 3-oxoacyl-[acyl-carrier-protein] synthase 2 GO:0006633|GO:0016747 SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 Gene3D G3DSA:3.40.47.10 270 420 2.4E-49 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 SUPERFAMILY SSF53901 220 420 1.52E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS20320 80dd02d3bfd07ad673d8bf779e51bf58 421 SMART SM00825 Beta-ketoacyl synthase 8 412 3.7E-13 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS22680 32d29544f5cb5a8fd385ba7267083589 252 Pfam PF13180 PDZ domain 179 248 1.7E-9 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS22680 32d29544f5cb5a8fd385ba7267083589 252 SMART SM00228 162 239 5.3E-8 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS22680 32d29544f5cb5a8fd385ba7267083589 252 Gene3D G3DSA:2.30.42.10 176 250 2.3E-16 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS22680 32d29544f5cb5a8fd385ba7267083589 252 SUPERFAMILY SSF50156 179 251 5.78E-16 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS01385 64bea7a324db91a514937b22623d84fc 206 TIGRFAM TIGR01755 flav_wrbA: NAD(P)H:quinone oxidoreductase, type IV 5 197 7.3E-44 T 17-03-2017 IPR010089 Flavoprotein WrbA GO:0010181|GO:0045892 KEGG: 00130+1.6.5.2|MetaCyc: PWY-7731 SHXM_RS01385 64bea7a324db91a514937b22623d84fc 206 Pfam PF03358 NADPH-dependent FMN reductase 15 150 1.9E-15 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS01385 64bea7a324db91a514937b22623d84fc 206 Gene3D G3DSA:3.40.50.360 4 201 6.1E-65 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS01385 64bea7a324db91a514937b22623d84fc 206 SUPERFAMILY SSF52218 6 199 1.7E-49 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 Pfam PF01842 ACT domain 198 254 3.2E-8 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 Pfam PF00800 Prephenate dehydratase 7 183 2.8E-45 T 17-03-2017 IPR001086 Prephenate dehydratase GO:0004664|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 PIRSF PIRSF001500 2 279 7.7E-59 T 17-03-2017 IPR008242 Bifunctional P-protein, chorismate mutase/prephenate dehydratase GO:0004106|GO:0004664|GO:0005737|GO:0009094 KEGG: 00400+4.2.1.51|MetaCyc: PWY-7432 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 SUPERFAMILY SSF55021 185 276 5.64E-24 T 17-03-2017 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 Gene3D G3DSA:3.40.190.10 94 171 3.5E-19 T 17-03-2017 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 Gene3D G3DSA:3.40.190.10 4 93 3.2E-25 T 17-03-2017 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 Gene3D G3DSA:3.30.70.260 190 277 2.8E-30 T 17-03-2017 SHXM_RS27680 3c7f9261c4af838920cd58fb58f4858e 311 SUPERFAMILY SSF53850 5 188 9.06E-49 T 17-03-2017 SHXM_RS35595 153600925c8432001add5d00e1949e48 214 Gene3D G3DSA:1.10.10.10 117 180 1.1E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35595 153600925c8432001add5d00e1949e48 214 Gene3D G3DSA:1.10.1740.10 5 112 1.3E-28 T 17-03-2017 SHXM_RS35595 153600925c8432001add5d00e1949e48 214 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 15 178 6.3E-26 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35595 153600925c8432001add5d00e1949e48 214 Pfam PF08281 Sigma-70, region 4 125 176 1.4E-16 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35595 153600925c8432001add5d00e1949e48 214 Pfam PF04542 Sigma-70 region 2 20 88 8.0E-15 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35595 153600925c8432001add5d00e1949e48 214 SUPERFAMILY SSF88659 118 179 3.05E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS35595 153600925c8432001add5d00e1949e48 214 SUPERFAMILY SSF88946 6 97 3.18E-21 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 Pfam PF00072 Response regulator receiver domain 4 115 1.1E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 Pfam PF00196 Bacterial regulatory proteins, luxR family 141 194 3.5E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 SMART SM00448 2 115 4.9E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 Gene3D G3DSA:1.10.10.10 144 201 7.9E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 SUPERFAMILY SSF46894 128 202 2.79E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 SMART SM00421 139 196 1.2E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 SUPERFAMILY SSF52172 1 127 1.37E-29 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 Gene3D G3DSA:3.40.50.2300 1 143 5.2E-34 T 17-03-2017 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 142 156 3.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 172 3.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 184 3.2E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS31565 5e671cd532bc3faaca485869e5a8630e 203 ProSitePatterns PS00622 LuxR-type HTH domain signature. 156 183 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08430 9cd2106f9aa221a9e3426e381d56fef8 139 SUPERFAMILY SSF103196 11 133 1.06E-26 T 17-03-2017 SHXM_RS08430 9cd2106f9aa221a9e3426e381d56fef8 139 SMART SM00960 13 104 2.1E-21 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS08430 9cd2106f9aa221a9e3426e381d56fef8 139 Gene3D G3DSA:3.30.450.30 11 131 7.1E-25 T 17-03-2017 SHXM_RS08430 9cd2106f9aa221a9e3426e381d56fef8 139 Pfam PF03259 Roadblock/LC7 domain 12 104 4.4E-22 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 SUPERFAMILY SSF52096 443 657 3.84E-43 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 Gene3D G3DSA:3.90.226.10 20 243 1.3E-49 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 Pfam PF01039 Carboxyl transferase domain 479 629 6.4E-20 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 Pfam PF01039 Carboxyl transferase domain 25 206 4.0E-26 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 193 204 1.9E-24 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 215 224 1.9E-24 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 127 145 1.9E-24 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 164 181 1.9E-24 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 PRINTS PR01070 Acetyl-CoA carboxylase carboxyl transferase beta subunit signature 93 107 1.9E-24 T 17-03-2017 IPR000438 Acetyl-CoA carboxylase carboxyl transferase, beta subunit GO:0003989|GO:0006633|GO:0009317 KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388 SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 SUPERFAMILY SSF52096 20 243 5.4E-57 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS16845 a3b4fc7d461193935b309898c31104fc 778 Gene3D G3DSA:3.90.226.10 448 656 4.8E-31 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS38155 c85a9e5e54cc153b43b87542bdb02704 125 SUPERFAMILY SSF46785 5 114 2.23E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38155 c85a9e5e54cc153b43b87542bdb02704 125 Gene3D G3DSA:1.10.10.10 4 115 8.3E-40 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38155 c85a9e5e54cc153b43b87542bdb02704 125 Pfam PF01638 HxlR-like helix-turn-helix 18 106 3.1E-26 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 Gene3D G3DSA:3.40.50.2300 70 176 1.5E-14 T 17-03-2017 SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 Pfam PF13377 Periplasmic binding protein-like domain 178 339 2.0E-42 T 17-03-2017 SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 14 54 1.4E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 SUPERFAMILY SSF47413 10 56 1.29E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 Gene3D G3DSA:1.10.260.40 10 54 8.1E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 SUPERFAMILY SSF53822 67 342 8.75E-73 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 Gene3D G3DSA:3.40.50.2300 177 341 4.5E-59 T 17-03-2017 SHXM_RS46090 60af0d89f3f62ae2160c94dfadc48127 347 SMART SM00354 9 77 1.6E-6 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 Pfam PF01494 FAD binding domain 4 352 3.2E-29 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 284 299 7.8E-14 T 17-03-2017 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 7.8E-14 T 17-03-2017 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 299 315 7.8E-14 T 17-03-2017 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 153 168 7.8E-14 T 17-03-2017 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 Gene3D G3DSA:3.50.50.60 272 359 9.8E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 Gene3D G3DSA:3.50.50.60 2 179 9.8E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 SUPERFAMILY SSF51905 1 174 4.48E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS03740 5adba51af84cf3bd2f5ff118dc73a724 434 SUPERFAMILY SSF51905 280 403 4.48E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44100 5eff95374a4cbfb4e853de5339eb147c 139 SUPERFAMILY SSF54909 21 125 9.12E-22 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44100 5eff95374a4cbfb4e853de5339eb147c 139 Pfam PF03795 YCII-related domain 17 107 2.8E-11 T 17-03-2017 IPR005545 YCII-related SHXM_RS44100 5eff95374a4cbfb4e853de5339eb147c 139 Gene3D G3DSA:3.30.70.1060 1 128 1.2E-37 T 17-03-2017 SHXM_RS28795 81d210a4c0aff19034ff0b1a6d8b2dc8 445 Gene3D G3DSA:3.30.565.10 314 418 1.2E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28795 81d210a4c0aff19034ff0b1a6d8b2dc8 445 Pfam PF07730 Histidine kinase 197 262 2.2E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS28795 81d210a4c0aff19034ff0b1a6d8b2dc8 445 SUPERFAMILY SSF55874 292 413 1.42E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28795 81d210a4c0aff19034ff0b1a6d8b2dc8 445 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 313 413 3.8E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 SUPERFAMILY SSF51735 2 172 1.01E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 Gene3D G3DSA:3.90.110.10 173 449 8.6E-95 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 SUPERFAMILY SSF56327 173 452 5.28E-63 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 ProSitePatterns PS01324 Glycosyl hydrolases family 4 signature. 144 174 - T 17-03-2017 IPR019802 Glycoside hydrolase, family 4, conserved site GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 PRINTS PR00732 Glycosyl hydrolase family 4 signature 2 17 1.1E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 PRINTS PR00732 Glycosyl hydrolase family 4 signature 115 135 1.1E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 PRINTS PR00732 Glycosyl hydrolase family 4 signature 169 180 1.1E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 PRINTS PR00732 Glycosyl hydrolase family 4 signature 144 161 1.1E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 PRINTS PR00732 Glycosyl hydrolase family 4 signature 195 207 1.1E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 PRINTS PR00732 Glycosyl hydrolase family 4 signature 101 114 1.1E-32 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 199 431 3.0E-44 T 17-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 Pfam PF02056 Family 4 glycosyl hydrolase 2 189 4.7E-42 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS46990 4bf829270adf1cc281e65a792f613cc0 457 Gene3D G3DSA:3.40.50.720 1 172 1.3E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 59 133 3.9E-21 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 SUPERFAMILY SSF50475 32 231 7.86E-68 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 ProSitePatterns PS01064 Pyridoxamine 5'-phosphate oxidase signature. 199 212 - T 17-03-2017 IPR019740 Pyridoxamine 5'-phosphate oxidase, conserved site GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 Pfam PF10590 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region 189 231 7.8E-21 T 17-03-2017 IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 Hamap MF_01629 Pyridoxine/pyridoxamine 5'-phosphate oxidase [pdxH]. 26 231 39.849 T 17-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 PIRSF PIRSF000190 11 231 1.6E-82 T 17-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 Gene3D G3DSA:2.30.110.10 32 231 3.0E-85 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS25575 d0a8a557bed39c9eb4a4c332b71b3251 231 TIGRFAM TIGR00558 pdxH: pyridoxamine 5'-phosphate oxidase 21 231 2.8E-80 T 17-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS16070 bd9244ea9322dd94573242fb5acccbf0 231 SUPERFAMILY SSF53254 1 208 1.54E-46 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS16070 bd9244ea9322dd94573242fb5acccbf0 231 TIGRFAM TIGR03848 MSMEG_4193: probable phosphomutase, MSMEG_4193 family 4 203 1.2E-94 T 17-03-2017 IPR022492 Phosphomutase MSMEG4193, putative SHXM_RS16070 bd9244ea9322dd94573242fb5acccbf0 231 Gene3D G3DSA:3.40.50.1240 2 217 1.3E-47 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS16070 bd9244ea9322dd94573242fb5acccbf0 231 SMART SM00855 3 162 1.6E-22 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS16070 bd9244ea9322dd94573242fb5acccbf0 231 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 4 202 3.3E-48 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 SUPERFAMILY SSF56634 8 484 1.26E-205 T 17-03-2017 IPR020835 Catalase-like domain GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 Gene3D G3DSA:2.40.180.10 8 362 7.4E-181 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PRINTS PR00067 Catalase signature 25 48 1.9E-68 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PRINTS PR00067 Catalase signature 325 351 1.9E-68 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PRINTS PR00067 Catalase signature 128 146 1.9E-68 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PRINTS PR00067 Catalase signature 109 126 1.9E-68 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PRINTS PR00067 Catalase signature 293 320 1.9E-68 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PRINTS PR00067 Catalase signature 88 106 1.9E-68 T 17-03-2017 IPR018028 Catalase, mono-functional, haem-containing GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 PIRSF PIRSF038928 2 487 1.5E-218 T 17-03-2017 IPR024711 Catalase, mono-functional, haem-containing, clades 1 and 3 GO:0004096|GO:0006979|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 ProSitePatterns PS00437 Catalase proximal heme-ligand signature. 338 346 - T 17-03-2017 IPR002226 Catalase haem-binding site GO:0020037 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 SMART SM01060 12 396 3.5E-280 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 Pfam PF06628 Catalase-related immune-responsive 422 483 3.5E-21 T 17-03-2017 IPR010582 Catalase immune-responsive domain KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 ProSitePatterns PS00438 Catalase proximal active site signature. 48 64 - T 17-03-2017 IPR024708 Catalase active site GO:0004096 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS34410 44debb05564c543e7ea587309451a6ca 488 Pfam PF00199 Catalase 12 393 1.1E-186 T 17-03-2017 IPR011614 Catalase core domain GO:0004096|GO:0020037|GO:0055114 KEGG: 00380+1.11.1.6|KEGG: 00630+1.11.1.6|Reactome: R-HSA-3299685|Reactome: R-HSA-74259 SHXM_RS12400 466381440f2a79a2a8a20c21c6212647 374 Pfam PF01321 Creatinase/Prolidase N-terminal domain 8 144 2.2E-10 T 17-03-2017 IPR000587 Creatinase, N-terminal GO:0016787 SHXM_RS12400 466381440f2a79a2a8a20c21c6212647 374 Pfam PF00557 Metallopeptidase family M24 152 354 9.8E-45 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS12400 466381440f2a79a2a8a20c21c6212647 374 Gene3D G3DSA:3.90.230.10 144 371 1.2E-57 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS12400 466381440f2a79a2a8a20c21c6212647 374 SUPERFAMILY SSF55920 143 372 3.93E-59 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS12400 466381440f2a79a2a8a20c21c6212647 374 Gene3D G3DSA:3.40.350.10 4 142 2.0E-9 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS12400 466381440f2a79a2a8a20c21c6212647 374 SUPERFAMILY SSF53092 5 143 5.93E-13 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS07930 7372654a53597f86877eb1eeabc2fb98 143 PIRSF PIRSF028743 4 143 1.0E-29 T 17-03-2017 IPR008634 Gas vesicle protein GvpO GO:0031412 SHXM_RS07930 7372654a53597f86877eb1eeabc2fb98 143 Pfam PF05800 Gas vesicle synthesis protein GvpO 49 138 3.7E-32 T 17-03-2017 IPR008634 Gas vesicle protein GvpO GO:0031412 SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 Pfam PF07549 SecD/SecF GG Motif 41 60 7.7E-5 T 17-03-2017 IPR022646 Protein-export membrane protein SecD/SecF/SecDF, conserved site SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 Gene3D G3DSA:1.20.1640.10 129 309 2.8E-19 T 17-03-2017 SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 Hamap MF_01464_B Protein-export membrane protein SecF [secF]. 18 306 24.396 T 17-03-2017 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 SUPERFAMILY SSF82866 127 306 1.7E-30 T 17-03-2017 SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 Pfam PF02355 Protein export membrane protein 111 304 4.0E-65 T 17-03-2017 IPR022813 Protein-export membrane protein SecD/SecF, archaeal and bacterial SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 TIGRFAM TIGR00916 2A0604s01: protein-export membrane protein, SecD/SecF family 119 292 1.2E-48 T 17-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 PRINTS PR01755 Bacterial translocase SecF protein signature 45 60 3.6E-22 T 17-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 PRINTS PR01755 Bacterial translocase SecF protein signature 155 169 3.6E-22 T 17-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 PRINTS PR01755 Bacterial translocase SecF protein signature 203 221 3.6E-22 T 17-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 PRINTS PR01755 Bacterial translocase SecF protein signature 238 253 3.6E-22 T 17-03-2017 IPR022645 Protein-export membrane protein SecD/SecF, bacterial SHXM_RS12525 3360263dc2bdfa13b56a6038eac29a93 373 TIGRFAM TIGR00966 3a0501s07: protein-export membrane protein SecF 46 295 1.1E-71 T 17-03-2017 IPR005665 Protein-export membrane protein SecF, bacterial GO:0006886|GO:0015450 SHXM_RS30025 2705f3ae1b1e3e829e50e729f1fe6f33 335 Gene3D G3DSA:3.40.50.300 4 228 4.7E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30025 2705f3ae1b1e3e829e50e729f1fe6f33 335 SUPERFAMILY SSF52540 7 228 1.23E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30025 2705f3ae1b1e3e829e50e729f1fe6f33 335 Pfam PF00005 ABC transporter 23 166 1.3E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30025 2705f3ae1b1e3e829e50e729f1fe6f33 335 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS30025 2705f3ae1b1e3e829e50e729f1fe6f33 335 SMART SM00382 32 215 1.2E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30025 2705f3ae1b1e3e829e50e729f1fe6f33 335 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 15 309 7.3E-103 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS15400 998d6867ebdc081bb3d642b3d86e1422 54 SUPERFAMILY SSF52540 5 54 1.04E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15400 998d6867ebdc081bb3d642b3d86e1422 54 Pfam PF00005 ABC transporter 23 53 2.5E-7 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS15400 998d6867ebdc081bb3d642b3d86e1422 54 Gene3D G3DSA:3.40.50.300 6 53 3.0E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 SMART SM00382 50 241 2.6E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 ProSitePatterns PS00211 ABC transporters family signature. 164 178 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 242 332 3.8E-23 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 243 312 1.1E-18 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 Gene3D G3DSA:3.40.50.300 9 271 6.1E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 SUPERFAMILY SSF52540 50 323 7.5E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS48435 019fe46b718f7eb0288520423562ff77 350 Pfam PF00005 ABC transporter 43 191 3.8E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS41585 e606edffc2a8c13bd1b2c99c69911112 427 SUPERFAMILY SSF103473 5 402 1.23E-46 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS41585 e606edffc2a8c13bd1b2c99c69911112 427 Gene3D G3DSA:1.20.1250.20 214 403 2.2E-23 T 17-03-2017 SHXM_RS41585 e606edffc2a8c13bd1b2c99c69911112 427 Gene3D G3DSA:1.20.1250.20 3 185 2.0E-16 T 17-03-2017 SHXM_RS41585 e606edffc2a8c13bd1b2c99c69911112 427 Pfam PF07690 Major Facilitator Superfamily 10 345 3.9E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS06610 5582c1ac6464f2f31d4f6ba9991a817e 623 SUPERFAMILY SSF51735 386 529 1.48E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06610 5582c1ac6464f2f31d4f6ba9991a817e 623 Gene3D G3DSA:3.30.70.1450 325 360 2.3E-4 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS06610 5582c1ac6464f2f31d4f6ba9991a817e 623 Gene3D G3DSA:3.40.50.720 384 517 1.3E-15 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06610 5582c1ac6464f2f31d4f6ba9991a817e 623 Gene3D G3DSA:3.40.50.720 121 260 1.1E-15 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06610 5582c1ac6464f2f31d4f6ba9991a817e 623 Pfam PF06241 Castor and Pollux, part of voltage-gated ion channel 269 361 2.0E-20 T 17-03-2017 IPR010420 CASTOR/POLLUX/SYM8 ion channels SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 Gene3D G3DSA:1.10.630.10 21 415 2.5E-112 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 Pfam PF00067 Cytochrome P450 289 385 6.0E-16 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 SUPERFAMILY SSF48264 22 415 6.42E-90 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00385 P450 superfamily signature 288 299 9.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00385 P450 superfamily signature 364 375 9.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00385 P450 superfamily signature 253 270 9.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00385 P450 superfamily signature 355 364 9.0E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 206 228 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 152 168 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 355 364 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 100 111 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 169 184 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 288 299 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 306 333 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 PRINTS PR00359 B-class P450 signature 364 375 6.9E-35 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS20710 f8d6a31efbe95c2cf0d8079e35e9ff45 421 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 357 366 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS21025 6d80b9984a093859c62ce6feeb2c39c0 250 SMART SM00382 25 219 6.4E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS21025 6d80b9984a093859c62ce6feeb2c39c0 250 SUPERFAMILY SSF52540 1 224 8.84E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21025 6d80b9984a093859c62ce6feeb2c39c0 250 Gene3D G3DSA:3.40.50.300 1 223 3.8E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21025 6d80b9984a093859c62ce6feeb2c39c0 250 Pfam PF00005 ABC transporter 16 163 1.4E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS05325 fde6e94f7ee78cf20cd609ea8898bbca 222 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 51 221 2.5E-51 T 17-03-2017 SHXM_RS05325 fde6e94f7ee78cf20cd609ea8898bbca 222 Gene3D G3DSA:3.40.50.720 51 221 3.0E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05325 fde6e94f7ee78cf20cd609ea8898bbca 222 Pfam PF08659 KR domain 51 222 2.6E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05325 fde6e94f7ee78cf20cd609ea8898bbca 222 SUPERFAMILY SSF51735 50 221 4.03E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09835 bca6a3f7f4f4d28c24ebd83e58861dc7 111 Pfam PF11774 Lsr2 1 106 2.8E-27 T 17-03-2017 IPR024412 Lsr2 SHXM_RS09835 bca6a3f7f4f4d28c24ebd83e58861dc7 111 ProDom PD026347 LSR2-LIKE LSR2 ANTIGEN IMMUNE PRECURSOR RESPONSE SIGNAL PLASMID LYSYL GP61 1 107 4.0E-15 T 17-03-2017 IPR024412 Lsr2 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 109 199 1.5E-10 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 Gene3D G3DSA:2.40.110.10 117 201 1.4E-28 T 17-03-2017 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 SUPERFAMILY SSF47203 228 368 2.09E-19 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 SUPERFAMILY SSF56645 3 207 1.1E-40 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 2 74 1.6E-7 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 Gene3D G3DSA:1.10.540.10 3 87 3.1E-13 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 Gene3D G3DSA:1.20.140.10 202 369 1.2E-31 T 17-03-2017 SHXM_RS10935 224a026c38a11b1b6ff9b900e697b736 374 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 230 351 9.6E-17 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 SUPERFAMILY SSF51735 3 234 1.78E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 6.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 126 134 6.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 6.3E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 Gene3D G3DSA:3.40.50.720 1 238 7.4E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 2.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 2.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 2.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 120 136 2.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 2.5E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05745 63e75d1c782bce1f776e2d27e16b3e18 238 Pfam PF00106 short chain dehydrogenase 5 201 1.4E-38 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS00165 20c20eeb99319e66a13b630a914dd457 533 SUPERFAMILY SSF53098 141 301 1.29E-7 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00165 20c20eeb99319e66a13b630a914dd457 533 Gene3D G3DSA:3.30.420.10 161 290 2.2E-5 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00165 20c20eeb99319e66a13b630a914dd457 533 Pfam PF00665 Integrase core domain 140 268 1.2E-14 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 Gene3D G3DSA:1.10.150.120 120 196 1.2E-33 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 Gene3D G3DSA:3.10.20.30 47 119 2.6E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 52 104 1.1E-8 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 SUPERFAMILY SSF54292 48 123 5.51E-25 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 SUPERFAMILY SSF47741 129 195 1.7E-30 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 84 92 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS10380 cc6b3f180237bffc595d50eb0759661d 197 Pfam PF01799 [2Fe-2S] binding domain 118 190 2.8E-30 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS47130 03ec17789330dae8038820f7d346f00b 255 SUPERFAMILY SSF100950 4 251 1.51E-51 T 17-03-2017 SHXM_RS47130 03ec17789330dae8038820f7d346f00b 255 SMART SM00882 9 211 4.8E-5 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS47130 03ec17789330dae8038820f7d346f00b 255 Gene3D G3DSA:3.40.810.20 4 252 8.6E-68 T 17-03-2017 SHXM_RS47130 03ec17789330dae8038820f7d346f00b 255 Pfam PF01144 Coenzyme A transferase 92 210 1.0E-7 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS04160 aa83377e91252e44a72b4117d6de6f73 231 Pfam PF06439 Domain of Unknown Function (DUF1080) 134 223 2.7E-7 T 17-03-2017 IPR010496 Domain of unknown function DUF1080 SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 Pfam PF13344 Haloacid dehalogenase-like hydrolase 10 109 6.6E-24 T 17-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 SUPERFAMILY SSF56784 7 256 2.85E-65 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 Gene3D G3DSA:3.40.50.10410 88 181 3.1E-33 T 17-03-2017 IPR023215 Nitrophenylphosphatase-like domain SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 TIGRFAM TIGR01460 HAD-SF-IIA: HAD hydrolase, family IIA 11 231 2.3E-44 T 17-03-2017 IPR006357 HAD-superfamily hydrolase, subfamily IIA SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 Gene3D G3DSA:3.40.50.1000 182 258 5.3E-39 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 Gene3D G3DSA:3.40.50.1000 6 83 5.3E-39 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS23270 26863cadd12b1d04731e5cc264a60e72 260 Pfam PF13242 HAD-hyrolase-like 182 255 3.1E-21 T 17-03-2017 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00111 Alpha/beta hydrolase fold signature 64 79 1.1E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00111 Alpha/beta hydrolase fold signature 108 121 1.1E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00111 Alpha/beta hydrolase fold signature 122 135 1.1E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 Pfam PF12697 Alpha/beta hydrolase family 40 293 3.4E-22 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 Gene3D G3DSA:3.40.50.1820 7 303 3.3E-72 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00412 Epoxide hydrolase signature 44 62 7.7E-24 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00412 Epoxide hydrolase signature 278 300 7.7E-24 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00412 Epoxide hydrolase signature 122 135 7.7E-24 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00412 Epoxide hydrolase signature 108 121 7.7E-24 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00412 Epoxide hydrolase signature 64 79 7.7E-24 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 PRINTS PR00412 Epoxide hydrolase signature 244 260 7.7E-24 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS26975 1cb94b7c36d8e1fc30c0026fac8f3646 308 SUPERFAMILY SSF53474 16 303 1.26E-67 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS18650 4f569258d29e0d5408e8cd54016e3030 694 Pfam PF12698 ABC-2 family transporter protein 490 674 7.7E-14 T 17-03-2017 SHXM_RS18650 4f569258d29e0d5408e8cd54016e3030 694 Pfam PF12698 ABC-2 family transporter protein 26 150 5.9E-8 T 17-03-2017 SHXM_RS18650 4f569258d29e0d5408e8cd54016e3030 694 TIGRFAM TIGR03061 pip_yhgE_Nterm: YhgE/Pip N-terminal domain 10 172 1.8E-57 T 17-03-2017 IPR017500 Phage infection protein, YhgE, N-terminal SHXM_RS18650 4f569258d29e0d5408e8cd54016e3030 694 TIGRFAM TIGR03062 pip_yhgE_Cterm: YhgE/Pip C-terminal domain 476 681 9.5E-72 T 17-03-2017 IPR017501 Phage infection protein, YhgE, C-terminal SHXM_RS32105 fead6aacea4c456e47dade23c3e9a819 261 Gene3D G3DSA:3.40.1080.10 3 232 2.6E-100 T 17-03-2017 SHXM_RS32105 fead6aacea4c456e47dade23c3e9a819 261 Pfam PF01144 Coenzyme A transferase 6 232 9.1E-73 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS32105 fead6aacea4c456e47dade23c3e9a819 261 TIGRFAM TIGR02429 pcaI_scoA_fam: 3-oxoacid CoA-transferase, A subunit 1 234 1.2E-72 T 17-03-2017 IPR012792 3-oxoacid CoA-transferase, subunit A GO:0008410 SHXM_RS32105 fead6aacea4c456e47dade23c3e9a819 261 ProSitePatterns PS01273 Coenzyme A transferases signature 1. 17 32 - T 17-03-2017 IPR004163 Coenzyme A transferase binding site GO:0008152|GO:0008410 SHXM_RS32105 fead6aacea4c456e47dade23c3e9a819 261 SUPERFAMILY SSF100950 2 235 4.54E-83 T 17-03-2017 SHXM_RS32105 fead6aacea4c456e47dade23c3e9a819 261 SMART SM00882 5 234 2.0E-81 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS15790 2ced7336db93d2466c5c2db1175c7e09 315 Gene3D G3DSA:3.40.50.970 3 163 7.1E-23 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS15790 2ced7336db93d2466c5c2db1175c7e09 315 Pfam PF02779 Transketolase, pyrimidine binding domain 3 161 8.0E-19 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS15790 2ced7336db93d2466c5c2db1175c7e09 315 Gene3D G3DSA:3.40.50.920 174 230 3.8E-6 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS15790 2ced7336db93d2466c5c2db1175c7e09 315 SMART SM00861 2 168 7.6E-16 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS15790 2ced7336db93d2466c5c2db1175c7e09 315 SUPERFAMILY SSF52922 172 309 1.7E-9 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS15790 2ced7336db93d2466c5c2db1175c7e09 315 SUPERFAMILY SSF52518 3 174 3.21E-31 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 Gene3D G3DSA:3.30.930.10 7 361 1.5E-143 T 17-03-2017 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 SUPERFAMILY SSF55681 5 369 4.07E-119 T 17-03-2017 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 TIGRFAM TIGR00389 glyS_dimeric: glycine--tRNA ligase 6 234 3.6E-80 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 Pfam PF03129 Anticodon binding domain 366 453 3.1E-22 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 SUPERFAMILY SSF52954 353 455 1.01E-33 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 Hamap MF_00253_B Glycine--tRNA ligase [glyQS]. 3 458 49.3 T 17-03-2017 IPR022961 Glycine-tRNA ligase, bacterial GO:0004820 KEGG: 00970+6.1.1.14 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 Gene3D G3DSA:3.40.50.800 362 454 2.1E-40 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 137 149 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 403 422 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 317 329 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 25 39 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 190 207 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 207 217 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 PRINTS PR01043 Glycyl-tRNA synthetase signature 158 175 6.6E-50 T 17-03-2017 IPR002315 Glycyl-tRNA synthetase GO:0000166|GO:0004820|GO:0005524|GO:0005737|GO:0006426 KEGG: 00970+6.1.1.14|Reactome: R-HSA-379716|Reactome: R-HSA-379726 SHXM_RS21015 b6e9f1e60a5ce04d6fa8f2e2bab865f2 460 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 157 332 5.1E-9 T 17-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS02130 0a7caa1b02301313f01688b6845a8de1 323 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 60 180 1.5E-10 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS02130 0a7caa1b02301313f01688b6845a8de1 323 SUPERFAMILY SSF53901 43 216 8.3E-16 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS02130 0a7caa1b02301313f01688b6845a8de1 323 Gene3D G3DSA:3.40.47.10 60 193 2.0E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 Gene3D G3DSA:1.10.357.10 61 195 6.1E-20 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 1.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 1.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 ProSitePatterns PS01081 TetR-type HTH domain signature. 30 61 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 SUPERFAMILY SSF48498 86 194 1.14E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 Gene3D G3DSA:1.10.10.60 6 60 1.4E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 SUPERFAMILY SSF46689 7 77 3.39E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16145 7bbe8659a87c988f86612974564b1af3 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 1.3E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30740 2474226e2020ff57d4c3022059af29f3 260 SUPERFAMILY SSF54593 12 178 2.86E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS30740 2474226e2020ff57d4c3022059af29f3 260 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 16 120 6.0E-6 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS30740 2474226e2020ff57d4c3022059af29f3 260 Gene3D G3DSA:3.10.180.10 11 125 2.3E-31 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS30740 2474226e2020ff57d4c3022059af29f3 260 Gene3D G3DSA:3.10.180.10 137 254 2.1E-29 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 Gene3D G3DSA:1.10.357.10 6 218 4.6E-55 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 63 3.0E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 SUPERFAMILY SSF46689 8 71 2.72E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 SUPERFAMILY SSF48498 81 217 3.41E-25 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 PRINTS PR00400 Tetracycline repressor protein signature 200 214 4.7E-11 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 PRINTS PR00400 Tetracycline repressor protein signature 83 102 4.7E-11 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 PRINTS PR00400 Tetracycline repressor protein signature 31 54 4.7E-11 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS01720 4ccb369766a78c4cf7bee5bdeda4e12c 231 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 75 217 4.8E-18 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS21500 e248197bf7d8a14e552d9a9960e35e58 323 Gene3D G3DSA:3.10.560.10 157 209 5.9E-7 T 17-03-2017 SHXM_RS21500 e248197bf7d8a14e552d9a9960e35e58 323 Pfam PF10531 SLBB domain 157 209 4.2E-11 T 17-03-2017 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS21500 e248197bf7d8a14e552d9a9960e35e58 323 Pfam PF12836 Helix-hairpin-helix motif 262 322 7.7E-21 T 17-03-2017 SHXM_RS21500 e248197bf7d8a14e552d9a9960e35e58 323 Gene3D G3DSA:1.10.150.320 258 321 5.0E-18 T 17-03-2017 SHXM_RS21500 e248197bf7d8a14e552d9a9960e35e58 323 SUPERFAMILY SSF47781 251 319 5.34E-26 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS28595 01a84f3e171ab99632fa46d747fa242d 142 SMART SM00960 9 101 5.6E-27 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS28595 01a84f3e171ab99632fa46d747fa242d 142 Gene3D G3DSA:3.30.450.30 6 128 3.2E-29 T 17-03-2017 SHXM_RS28595 01a84f3e171ab99632fa46d747fa242d 142 SUPERFAMILY SSF103196 2 130 2.44E-34 T 17-03-2017 SHXM_RS28595 01a84f3e171ab99632fa46d747fa242d 142 Pfam PF03259 Roadblock/LC7 domain 8 101 7.1E-24 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS15385 c212c30b76cb6ac99a6964606f14d60d 574 Pfam PF05598 Transposase domain (DUF772) 60 132 3.8E-17 T 17-03-2017 IPR008490 Transposase InsH, N-terminal SHXM_RS15385 c212c30b76cb6ac99a6964606f14d60d 574 Pfam PF13751 Transposase DDE domain 410 536 7.1E-27 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS24220 dbff2febda5535cb86e94c4ce1e4b019 177 Pfam PF05995 Cysteine dioxygenase type I 18 149 4.5E-22 T 17-03-2017 IPR010300 Cysteine dioxygenase type I GO:0005506|GO:0016702|GO:0055114 KEGG: 00270+1.13.11.20|KEGG: 00430+1.13.11.20|MetaCyc: PWY-5331|Reactome: R-HSA-1614558 SHXM_RS24220 dbff2febda5535cb86e94c4ce1e4b019 177 SUPERFAMILY SSF51182 20 149 3.22E-31 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS24220 dbff2febda5535cb86e94c4ce1e4b019 177 Gene3D G3DSA:2.60.120.10 45 149 7.0E-19 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS33555 24b525906898e5b8f89449dccf125a97 228 Gene3D G3DSA:3.40.50.300 8 221 1.8E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33555 24b525906898e5b8f89449dccf125a97 228 SUPERFAMILY SSF52540 8 224 4.69E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33555 24b525906898e5b8f89449dccf125a97 228 Pfam PF00005 ABC transporter 23 171 4.9E-34 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33555 24b525906898e5b8f89449dccf125a97 228 SMART SM00382 32 220 1.7E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS23055 b519e1087eeebfaf5c32e9668a233ea2 203 Gene3D G3DSA:3.10.129.10 2 145 1.9E-38 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23055 b519e1087eeebfaf5c32e9668a233ea2 203 SUPERFAMILY SSF54637 1 146 6.5E-27 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23055 b519e1087eeebfaf5c32e9668a233ea2 203 Pfam PF07977 FabA-like domain 11 140 9.1E-13 T 17-03-2017 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS41745 d5329c1825fdce5a104d70f3564ce50c 588 SUPERFAMILY SSF51126 413 489 7.33E-7 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS41745 d5329c1825fdce5a104d70f3564ce50c 588 SUPERFAMILY SSF51126 294 365 7.33E-7 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS28610 26a21950e4ef8055b3d3ff4383c3fd2e 401 Gene3D G3DSA:1.10.630.10 8 397 2.5E-75 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS28610 26a21950e4ef8055b3d3ff4383c3fd2e 401 PRINTS PR00359 B-class P450 signature 286 313 6.7E-14 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS28610 26a21950e4ef8055b3d3ff4383c3fd2e 401 PRINTS PR00359 B-class P450 signature 140 156 6.7E-14 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS28610 26a21950e4ef8055b3d3ff4383c3fd2e 401 PRINTS PR00359 B-class P450 signature 333 342 6.7E-14 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS28610 26a21950e4ef8055b3d3ff4383c3fd2e 401 SUPERFAMILY SSF48264 5 397 2.49E-51 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 SUPERFAMILY SSF56801 8 531 4.58E-146 T 17-03-2017 SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 Gene3D G3DSA:3.40.50.980 8 195 2.3E-33 T 17-03-2017 SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 Pfam PF13193 AMP-binding enzyme C-terminal domain 448 523 1.0E-20 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 Gene3D G3DSA:3.30.300.30 434 531 5.5E-32 T 17-03-2017 SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 ProSitePatterns PS00455 Putative AMP-binding domain signature. 190 201 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 Gene3D G3DSA:3.40.50.980 196 350 2.2E-40 T 17-03-2017 SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 Gene3D G3DSA:2.30.38.10 356 430 2.1E-26 T 17-03-2017 SHXM_RS31810 4720bcaa65cdbf0061abae11c63d4514 536 Pfam PF00501 AMP-binding enzyme 16 439 4.3E-96 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS47815 34b015e56d65663d266856dc9b5186f9 308 Pfam PF05368 NmrA-like family 4 246 3.2E-28 T 17-03-2017 IPR008030 NmrA-like domain Reactome: R-HSA-70635 SHXM_RS47815 34b015e56d65663d266856dc9b5186f9 308 Gene3D G3DSA:3.40.50.720 3 241 2.4E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47815 34b015e56d65663d266856dc9b5186f9 308 SUPERFAMILY SSF51735 3 281 3.55E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25405 f03ba8490527fc2712236333c74dae19 429 Gene3D G3DSA:2.60.40.10 327 420 1.9E-6 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS12380 42419a67eef306f44edace85146007d0 193 Gene3D G3DSA:3.40.50.2020 12 179 4.2E-49 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS12380 42419a67eef306f44edace85146007d0 193 Pfam PF00156 Phosphoribosyl transferase domain 11 154 1.3E-19 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS12380 42419a67eef306f44edace85146007d0 193 SUPERFAMILY SSF53271 12 180 2.88E-40 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS12380 42419a67eef306f44edace85146007d0 193 Hamap MF_01219 Bifunctional protein PyrR [pyrR]. 9 184 36.978 T 17-03-2017 IPR023050 Bifunctional protein PyrR KEGG: 00240+2.4.2.9|MetaCyc: PWY-7183 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 Pfam PF03167 Uracil DNA glycosylase superfamily 55 210 1.9E-16 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 ProSitePatterns PS00130 Uracil-DNA glycosylase signature. 61 70 - T 17-03-2017 IPR018085 Uracil-DNA glycosylase, active site GO:0006281|GO:0016799 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 Hamap MF_00148 Uracil-DNA glycosylase [ung]. 11 223 33.399 T 17-03-2017 IPR002043 Uracil-DNA glycosylase GO:0004844|GO:0006281|GO:0006284 Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 SUPERFAMILY SSF52141 9 224 7.2E-70 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 Gene3D G3DSA:3.40.470.10 7 224 1.9E-79 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 SMART SM00986 53 212 9.9E-29 T 17-03-2017 IPR005122 Uracil-DNA glycosylase-like Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SHXM_RS42740 a62923be340d9aae88b33be93f63329a 225 SMART SM00987 53 212 9.9E-29 T 17-03-2017 SHXM_RS30800 c185098faec722e75d34a264e994d1f7 306 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 30 175 1.9E-31 T 17-03-2017 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS11565 d9a8fd98824ed5b64c7924fd6e91d436 591 Hamap MF_01148 Apolipoprotein N-acyltransferase [lnt]. 80 567 16.776 T 17-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 SHXM_RS11565 d9a8fd98824ed5b64c7924fd6e91d436 591 TIGRFAM TIGR00546 lnt: apolipoprotein N-acyltransferase 131 529 6.6E-76 T 17-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 SHXM_RS11565 d9a8fd98824ed5b64c7924fd6e91d436 591 Gene3D G3DSA:3.60.110.10 287 558 2.7E-35 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS11565 d9a8fd98824ed5b64c7924fd6e91d436 591 Pfam PF00795 Carbon-nitrogen hydrolase 326 550 5.2E-22 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS11565 d9a8fd98824ed5b64c7924fd6e91d436 591 SUPERFAMILY SSF56317 290 559 5.23E-42 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS32080 ed1c19c744aefdbb22318b5035766509 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 71 3.2E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32080 ed1c19c744aefdbb22318b5035766509 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 4.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32080 ed1c19c744aefdbb22318b5035766509 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 4.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32080 ed1c19c744aefdbb22318b5035766509 196 SUPERFAMILY SSF48498 92 195 8.22E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32080 ed1c19c744aefdbb22318b5035766509 196 SUPERFAMILY SSF46689 15 94 1.45E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS32080 ed1c19c744aefdbb22318b5035766509 196 Gene3D G3DSA:1.10.357.10 15 195 3.5E-40 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS37655 d6f9f93097d0bbd0bc69d07bf8b92ab5 142 Gene3D G3DSA:2.40.50.140 53 136 2.3E-8 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS37655 d6f9f93097d0bbd0bc69d07bf8b92ab5 142 PIRSF PIRSF006910 7 139 6.4E-53 T 17-03-2017 IPR016499 Nucleic acid binding protein, Rv2694c, predicted SHXM_RS29070 0c6352a2da525ddc1cf03d917066623f 547 SUPERFAMILY SSF69318 90 172 1.01E-8 T 17-03-2017 SHXM_RS29070 0c6352a2da525ddc1cf03d917066623f 547 Pfam PF01839 FG-GAP repeat 153 175 1.8E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS29070 0c6352a2da525ddc1cf03d917066623f 547 Gene3D G3DSA:2.130.10.130 178 507 7.2E-18 T 17-03-2017 SHXM_RS29070 0c6352a2da525ddc1cf03d917066623f 547 Gene3D G3DSA:2.130.10.130 90 172 2.6E-9 T 17-03-2017 SHXM_RS29070 0c6352a2da525ddc1cf03d917066623f 547 SUPERFAMILY SSF69318 155 508 2.62E-21 T 17-03-2017 SHXM_RS22610 897cdf3eaa44d2285b7e1e19a00f65be 237 Gene3D G3DSA:2.40.50.100 159 227 5.2E-24 T 17-03-2017 SHXM_RS22610 897cdf3eaa44d2285b7e1e19a00f65be 237 ProSitePatterns PS00188 Biotin-requiring enzymes attachment site. 184 201 - T 17-03-2017 IPR001882 Biotin-binding site Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS22610 897cdf3eaa44d2285b7e1e19a00f65be 237 SUPERFAMILY SSF51230 155 227 1.44E-20 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS22610 897cdf3eaa44d2285b7e1e19a00f65be 237 Pfam PF00364 Biotin-requiring enzyme 161 226 1.5E-17 T 17-03-2017 IPR000089 Biotin/lipoyl attachment SHXM_RS50560 72e658b8f9fde8374ffb0edb8f3fcc70 442 SUPERFAMILY SSF51679 1 434 3.93E-118 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50560 72e658b8f9fde8374ffb0edb8f3fcc70 442 Pfam PF00296 Luciferase-like monooxygenase 31 383 4.8E-60 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50560 72e658b8f9fde8374ffb0edb8f3fcc70 442 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 14 428 1.7E-144 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS50560 72e658b8f9fde8374ffb0edb8f3fcc70 442 PIRSF PIRSF000337 2 442 5.8E-136 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS50560 72e658b8f9fde8374ffb0edb8f3fcc70 442 Gene3D G3DSA:3.20.20.30 348 435 2.9E-121 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50560 72e658b8f9fde8374ffb0edb8f3fcc70 442 Gene3D G3DSA:3.20.20.30 2 307 2.9E-121 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS40770 32d141acc2ebfaa054ca7dc77cadbe32 395 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 13 128 1.1E-6 T 17-03-2017 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS40770 32d141acc2ebfaa054ca7dc77cadbe32 395 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 10 385 5.8E-50 T 17-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SHXM_RS40770 32d141acc2ebfaa054ca7dc77cadbe32 395 Gene3D G3DSA:3.40.50.2000 215 368 6.4E-30 T 17-03-2017 SHXM_RS40770 32d141acc2ebfaa054ca7dc77cadbe32 395 Gene3D G3DSA:3.40.50.2000 1 128 2.6E-23 T 17-03-2017 SHXM_RS40770 32d141acc2ebfaa054ca7dc77cadbe32 395 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 221 354 1.2E-15 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS40770 32d141acc2ebfaa054ca7dc77cadbe32 395 SUPERFAMILY SSF53756 1 385 3.62E-71 T 17-03-2017 SHXM_RS03800 aba44d03eff0b1eca465dfa919d50936 263 Pfam PF08242 Methyltransferase domain 98 199 3.1E-14 T 17-03-2017 IPR013217 Methyltransferase type 12 SHXM_RS03800 aba44d03eff0b1eca465dfa919d50936 263 Gene3D G3DSA:3.40.50.150 60 247 1.1E-18 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03800 aba44d03eff0b1eca465dfa919d50936 263 SUPERFAMILY SSF53335 87 244 7.15E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08050 8e38382a87b736edbe11181cf3c5856f 166 Gene3D G3DSA:3.90.79.10 2 156 2.0E-30 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS08050 8e38382a87b736edbe11181cf3c5856f 166 ProSitePatterns PS00893 Nudix box signature. 47 68 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS08050 8e38382a87b736edbe11181cf3c5856f 166 Pfam PF00293 NUDIX domain 4 151 2.6E-16 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS08050 8e38382a87b736edbe11181cf3c5856f 166 SUPERFAMILY SSF55811 2 156 2.3E-20 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS35955 b53e222c94a0fcfe46619bdac3360def 126 SUPERFAMILY SSF51230 4 125 4.58E-38 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS35955 b53e222c94a0fcfe46619bdac3360def 126 Hamap MF_00272 Glycine cleavage system H protein [gcvH]. 4 125 28.712 T 17-03-2017 IPR002930 Glycine cleavage system H-protein SHXM_RS35955 b53e222c94a0fcfe46619bdac3360def 126 ProSitePatterns PS00189 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. 49 78 - T 17-03-2017 IPR003016 2-oxo acid dehydrogenase, lipoyl-binding site Reactome: R-HSA-389661 SHXM_RS35955 b53e222c94a0fcfe46619bdac3360def 126 Gene3D G3DSA:2.40.50.100 6 126 1.9E-44 T 17-03-2017 SHXM_RS35955 b53e222c94a0fcfe46619bdac3360def 126 TIGRFAM TIGR00527 gcvH: glycine cleavage system H protein 3 124 1.4E-43 T 17-03-2017 IPR017453 Glycine cleavage system H-protein, subgroup GO:0005960|GO:0019464 Reactome: R-HSA-389661|Reactome: R-HSA-6783984 SHXM_RS35955 b53e222c94a0fcfe46619bdac3360def 126 Pfam PF01597 Glycine cleavage H-protein 7 124 3.7E-40 T 17-03-2017 IPR002930 Glycine cleavage system H-protein SHXM_RS42600 6f0eb015482a459b95898c5adb8ed38b 146 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 6 90 7.3E-16 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS42600 6f0eb015482a459b95898c5adb8ed38b 146 SUPERFAMILY SSF50475 5 132 4.46E-29 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS42600 6f0eb015482a459b95898c5adb8ed38b 146 Gene3D G3DSA:2.30.110.10 6 131 1.9E-28 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS42600 6f0eb015482a459b95898c5adb8ed38b 146 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 10 130 2.5E-31 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS42415 c058b276b0ef4740792aa5f83bf486ee 805 SUPERFAMILY SSF48208 290 768 5.67E-84 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS42415 c058b276b0ef4740792aa5f83bf486ee 805 Gene3D G3DSA:2.70.98.50 48 418 3.2E-135 T 17-03-2017 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SHXM_RS42415 c058b276b0ef4740792aa5f83bf486ee 805 PIRSF PIRSF007663 20 790 1.9E-279 T 17-03-2017 IPR016518 Alpha-L-fucosidase GO:0004560 KEGG: 00511+3.2.1.51 SHXM_RS42415 c058b276b0ef4740792aa5f83bf486ee 805 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 48 284 2.0E-73 T 17-03-2017 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SHXM_RS28820 7867c0a645603e27eec12797e830366b 382 SUPERFAMILY SSF117892 38 179 2.22E-25 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS28820 7867c0a645603e27eec12797e830366b 382 Pfam PF01145 SPFH domain / Band 7 family 23 187 4.5E-15 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS28820 7867c0a645603e27eec12797e830366b 382 SMART SM00244 2 172 0.0048 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS35660 15408eceed34a10773b5f3960f6c8bf7 171 Gene3D G3DSA:1.10.10.10 3 105 8.4E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35660 15408eceed34a10773b5f3960f6c8bf7 171 Pfam PF01638 HxlR-like helix-turn-helix 17 104 5.9E-13 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS35660 15408eceed34a10773b5f3960f6c8bf7 171 SUPERFAMILY SSF46785 6 122 2.39E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09205 340f388c01ed2c60c62fe60a980b65a6 401 SUPERFAMILY SSF55920 179 388 6.02E-25 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS09205 340f388c01ed2c60c62fe60a980b65a6 401 Pfam PF00557 Metallopeptidase family M24 187 371 1.7E-15 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS09205 340f388c01ed2c60c62fe60a980b65a6 401 Gene3D G3DSA:3.40.350.10 47 126 8.4E-4 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS09205 340f388c01ed2c60c62fe60a980b65a6 401 SUPERFAMILY SSF53092 47 176 8.11E-5 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS09205 340f388c01ed2c60c62fe60a980b65a6 401 Gene3D G3DSA:3.90.230.10 176 372 6.3E-23 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS42140 d218d5a1de88cb87cb9100f5df8fab1a 351 SUPERFAMILY SSF53822 40 334 1.45E-60 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS42140 d218d5a1de88cb87cb9100f5df8fab1a 351 Gene3D G3DSA:3.40.50.2300 159 334 6.0E-37 T 17-03-2017 SHXM_RS42140 d218d5a1de88cb87cb9100f5df8fab1a 351 Gene3D G3DSA:3.40.50.2300 42 158 1.6E-35 T 17-03-2017 SHXM_RS42140 d218d5a1de88cb87cb9100f5df8fab1a 351 Pfam PF13407 Periplasmic binding protein domain 42 308 8.8E-47 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS04860 c7692ace75186bffc98e88cbe74381ae 274 Pfam PF11790 Glycosyl hydrolase catalytic core 50 259 1.0E-53 T 17-03-2017 IPR024655 Uncharacterised protein family, glycosyl hydrolase catalytic domain SHXM_RS04860 c7692ace75186bffc98e88cbe74381ae 274 SUPERFAMILY SSF51445 71 260 3.14E-26 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04860 c7692ace75186bffc98e88cbe74381ae 274 Gene3D G3DSA:3.20.20.80 104 270 2.9E-19 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS43745 cbcd39c8f5aecc6a1567943502092401 198 SUPERFAMILY SSF49299 84 192 7.06E-6 T 17-03-2017 IPR000601 PKD domain SHXM_RS43745 cbcd39c8f5aecc6a1567943502092401 198 Pfam PF16640 Bacterial Ig-like domain (group 3) 107 196 2.1E-13 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS36250 ccaefb8a4b8149585cccd926f6b6d680 527 SUPERFAMILY SSF52096 254 526 2.25E-89 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS36250 ccaefb8a4b8149585cccd926f6b6d680 527 Gene3D G3DSA:3.90.226.10 12 265 7.5E-75 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS36250 ccaefb8a4b8149585cccd926f6b6d680 527 Gene3D G3DSA:3.90.226.10 266 526 3.7E-101 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS36250 ccaefb8a4b8149585cccd926f6b6d680 527 SUPERFAMILY SSF52096 14 267 9.51E-74 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS36250 ccaefb8a4b8149585cccd926f6b6d680 527 Pfam PF01039 Carboxyl transferase domain 40 524 9.9E-197 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 229 377 6.0E-47 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 Gene3D G3DSA:1.10.540.10 9 121 3.2E-31 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 119 2.1E-24 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 125 216 4.2E-21 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 SUPERFAMILY SSF47203 228 377 1.93E-53 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 Gene3D G3DSA:1.20.140.10 219 377 1.8E-61 T 17-03-2017 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 Gene3D G3DSA:2.40.110.10 124 218 4.8E-31 T 17-03-2017 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 336 355 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS42225 8d00d6ea738f83d90b99d60c7b9d1d55 379 SUPERFAMILY SSF56645 7 229 8.25E-65 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS37505 bc21157b3d782c48fb06db3b1278ac65 134 Gene3D G3DSA:1.25.40.10 44 127 7.9E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS37505 bc21157b3d782c48fb06db3b1278ac65 134 SUPERFAMILY SSF81901 43 126 1.57E-12 T 17-03-2017 SHXM_RS11300 68b2f1ad8c466bca5135b991fa8b0e62 402 Pfam PF00144 Beta-lactamase 55 357 4.0E-48 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS11300 68b2f1ad8c466bca5135b991fa8b0e62 402 SUPERFAMILY SSF56601 51 359 2.18E-60 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS11300 68b2f1ad8c466bca5135b991fa8b0e62 402 Gene3D G3DSA:3.40.710.10 55 363 9.9E-60 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Pfam PF00749 tRNA synthetases class I (E and Q), catalytic domain 10 328 5.0E-90 T 17-03-2017 IPR020058 Glutamyl/glutaminyl-tRNA synthetase, class Ib, catalytic domain GO:0005524|GO:0016876|GO:0043039 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 SUPERFAMILY SSF52374 10 324 6.44E-105 T 17-03-2017 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Gene3D G3DSA:3.90.800.10 75 198 2.2E-40 T 17-03-2017 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Hamap MF_00022_B Glutamate--tRNA ligase [gltX]. 10 490 32.251 T 17-03-2017 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Gene3D G3DSA:1.10.10.350 395 490 3.8E-23 T 17-03-2017 IPR020751 Aminoacyl-tRNA synthetase, class I, anticodon-binding domain, subdomain 2 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 PRINTS PR00987 Glutamyl-tRNA synthetase signature 13 25 2.5E-22 T 17-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 PRINTS PR00987 Glutamyl-tRNA synthetase signature 27 38 2.5E-22 T 17-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 PRINTS PR00987 Glutamyl-tRNA synthetase signature 42 55 2.5E-22 T 17-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 PRINTS PR00987 Glutamyl-tRNA synthetase signature 198 208 2.5E-22 T 17-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 PRINTS PR00987 Glutamyl-tRNA synthetase signature 214 222 2.5E-22 T 17-03-2017 IPR000924 Glutamyl/glutaminyl-tRNA synthetase GO:0000166|GO:0005524|GO:0005737|GO:0016876|GO:0043039 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 SUPERFAMILY SSF48163 325 490 1.57E-34 T 17-03-2017 IPR008925 Aminoacyl-tRNA synthetase, class I, anticodon-binding GO:0000049 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Gene3D G3DSA:3.40.50.620 200 255 8.2E-43 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Gene3D G3DSA:3.40.50.620 10 74 8.2E-43 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 Gene3D G3DSA:1.10.1160.10 258 340 2.3E-29 T 17-03-2017 IPR020061 Glutamyl/glutaminyl-tRNA synthetase, class Ib, alpha-bundle domain GO:0000166|GO:0004812|GO:0005524|GO:0005737|GO:0006418 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188 SHXM_RS36310 a18ba5476c921f86db42d6b26c408ce6 495 TIGRFAM TIGR00464 gltX_bact: glutamate--tRNA ligase 10 488 1.5E-141 T 17-03-2017 IPR004527 Glutamate-tRNA ligase, bacterial/mitochondrial GO:0000166|GO:0004818|GO:0005524|GO:0005737|GO:0006424 KEGG: 00860+6.1.1.17|KEGG: 00970+6.1.1.17|MetaCyc: PWY-5188|Reactome: R-HSA-379726 SHXM_RS04175 450462941480d0f836cb594dd9ea1462 227 SUPERFAMILY SSF46689 23 99 2.99E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04175 450462941480d0f836cb594dd9ea1462 227 SUPERFAMILY SSF48498 97 202 2.97E-16 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS04175 450462941480d0f836cb594dd9ea1462 227 Pfam PF00440 Bacterial regulatory proteins, tetR family 34 78 2.2E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04175 450462941480d0f836cb594dd9ea1462 227 Gene3D G3DSA:1.10.357.10 22 206 1.8E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04175 450462941480d0f836cb594dd9ea1462 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 46 7.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04175 450462941480d0f836cb594dd9ea1462 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 53 76 7.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48145 085a98445951ae93cc71ca063f906058 804 SUPERFAMILY SSF56349 482 675 4.12E-20 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS48145 085a98445951ae93cc71ca063f906058 804 Pfam PF00589 Phage integrase family 483 663 2.7E-12 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS48145 085a98445951ae93cc71ca063f906058 804 Gene3D G3DSA:1.10.443.10 480 669 1.2E-20 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS21280 1d62bdcb7cde9138ddc4a425354daabe 247 Gene3D G3DSA:3.40.1280.10 11 247 5.9E-67 T 17-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SHXM_RS21280 1d62bdcb7cde9138ddc4a425354daabe 247 TIGRFAM TIGR00046 TIGR00046: RNA methyltransferase, RsmE family 20 239 4.0E-32 T 17-03-2017 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS21280 1d62bdcb7cde9138ddc4a425354daabe 247 SUPERFAMILY SSF75217 78 247 5.76E-44 T 17-03-2017 IPR029028 Alpha/beta knot methyltransferases SHXM_RS21280 1d62bdcb7cde9138ddc4a425354daabe 247 Pfam PF04452 RNA methyltransferase 21 239 2.5E-59 T 17-03-2017 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS21280 1d62bdcb7cde9138ddc4a425354daabe 247 PIRSF PIRSF015601 5 246 3.8E-44 T 17-03-2017 IPR006700 Ribosomal RNA small subunit methyltransferase E GO:0006364|GO:0008168 KEGG: 00670+2.1.1.19|MetaCyc: PWY-2201 SHXM_RS21280 1d62bdcb7cde9138ddc4a425354daabe 247 SUPERFAMILY SSF88697 5 72 1.04E-9 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS50085 ecd0ef40179146ea78210057c0e27cc8 464 Pfam PF13556 PucR C-terminal helix-turn-helix domain 380 423 2.2E-7 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS11080 858cfa7f9195f0a0aaf6916637e4c0ee 385 Gene3D G3DSA:3.40.50.720 1 213 1.3E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11080 858cfa7f9195f0a0aaf6916637e4c0ee 385 SUPERFAMILY SSF51735 1 311 7.49E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11080 858cfa7f9195f0a0aaf6916637e4c0ee 385 Pfam PF07993 Male sterility protein 6 268 6.2E-41 T 17-03-2017 IPR013120 Male sterility, NAD-binding Reactome: R-HSA-8848584 SHXM_RS02535 6f47cb64d66bcd6095c56dc33bc04959 255 Pfam PF02585 GlcNAc-PI de-N-acetylase 7 132 1.5E-18 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS02535 6f47cb64d66bcd6095c56dc33bc04959 255 Gene3D G3DSA:3.40.50.10320 5 241 1.6E-49 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS02535 6f47cb64d66bcd6095c56dc33bc04959 255 SUPERFAMILY SSF102588 5 226 6.41E-44 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS11805 427cac74380453d30574264b78fa0d1f 107 SMART SM00418 4 95 0.0013 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS11805 427cac74380453d30574264b78fa0d1f 107 Gene3D G3DSA:1.10.10.10 4 94 1.2E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11805 427cac74380453d30574264b78fa0d1f 107 SMART SM00347 4 102 0.002 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS11805 427cac74380453d30574264b78fa0d1f 107 Pfam PF13601 Winged helix DNA-binding domain 15 93 1.8E-23 T 17-03-2017 IPR027395 Winged helix DNA-binding domain SHXM_RS11805 427cac74380453d30574264b78fa0d1f 107 SUPERFAMILY SSF46785 5 97 3.55E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24105 6adaf5ddcf226c10c816a77c7f0e82be 285 Pfam PF00156 Phosphoribosyl transferase domain 233 278 2.9E-6 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS24105 6adaf5ddcf226c10c816a77c7f0e82be 285 SUPERFAMILY SSF53271 157 278 1.31E-14 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS24105 6adaf5ddcf226c10c816a77c7f0e82be 285 Gene3D G3DSA:3.40.50.2020 156 278 2.5E-16 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS34340 285db10ff1a5d14b8b961c139515a9dc 227 Pfam PF01987 Mitochondrial biogenesis AIM24 19 215 2.5E-38 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS34340 285db10ff1a5d14b8b961c139515a9dc 227 SUPERFAMILY SSF51219 18 217 4.45E-48 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS34340 285db10ff1a5d14b8b961c139515a9dc 227 Gene3D G3DSA:3.60.160.10 16 217 1.2E-42 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS04745 16e5ca675da0f2776367194620bfeacc 448 Pfam PF13646 HEAT repeats 41 110 5.9E-8 T 17-03-2017 SHXM_RS04745 16e5ca675da0f2776367194620bfeacc 448 SUPERFAMILY SSF56436 177 445 4.71E-52 T 17-03-2017 IPR016187 C-type lectin fold SHXM_RS04745 16e5ca675da0f2776367194620bfeacc 448 Gene3D G3DSA:3.90.1580.10 169 445 1.5E-54 T 17-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 SHXM_RS04745 16e5ca675da0f2776367194620bfeacc 448 SUPERFAMILY SSF48371 37 112 2.59E-5 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS04745 16e5ca675da0f2776367194620bfeacc 448 Pfam PF03781 Sulfatase-modifying factor enzyme 1 176 442 2.7E-45 T 17-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 SUPERFAMILY SSF52418 88 356 1.96E-82 T 17-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 Pfam PF00591 Glycosyl transferase family, a/b domain 89 344 1.8E-80 T 17-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 Hamap MF_00211 Anthranilate phosphoribosyltransferase [trpD]. 20 354 35.463 T 17-03-2017 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 SUPERFAMILY SSF47648 18 84 7.85E-21 T 17-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 Pfam PF02885 Glycosyl transferase family, helical bundle domain 20 81 4.7E-20 T 17-03-2017 IPR017459 Glycosyl transferase family 3, N-terminal domain Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 Gene3D G3DSA:3.40.1030.10 87 356 1.0E-104 T 17-03-2017 IPR000312 Glycosyl transferase, family 3 GO:0008152|GO:0016757 Reactome: R-HSA-73614|Reactome: R-HSA-73621 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 Gene3D G3DSA:1.20.970.10 20 84 2.1E-25 T 17-03-2017 SHXM_RS18865 3bb6cdddf7b6f751500f41d97c1e9f73 357 TIGRFAM TIGR01245 trpD: anthranilate phosphoribosyltransferase 23 353 2.1E-110 T 17-03-2017 IPR005940 Anthranilate phosphoribosyl transferase GO:0000162|GO:0004048 KEGG: 00400+2.4.2.18 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 SUPERFAMILY SSF100950 27 364 2.58E-95 T 17-03-2017 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 TIGRFAM TIGR00524 eIF-2B_rel: eIF-2B alpha/beta/delta-related uncharacterized proteins 48 363 6.2E-83 T 17-03-2017 IPR011559 Initiation factor 2B alpha/beta/delta GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 Pfam PF01008 Initiation factor 2 subunit family 86 363 2.1E-61 T 17-03-2017 IPR000649 Initiation factor 2B-related GO:0044237 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 Gene3D G3DSA:3.40.50.10470 173 367 4.9E-60 T 17-03-2017 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 TIGRFAM TIGR00512 salvage_mtnA: S-methyl-5-thioribose-1-phosphate isomerase 29 362 4.0E-104 T 17-03-2017 IPR005251 Methylthioribose-1-phosphate isomerase GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 Hamap MF_01678 Putative methylthioribose-1-phosphate isomerase [mtnA]. 16 373 35.049 T 17-03-2017 IPR005251 Methylthioribose-1-phosphate isomerase GO:0044249 KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 SHXM_RS24125 518e4379b18e2d22049bf09442a348c7 385 Gene3D G3DSA:1.20.120.420 25 172 4.3E-37 T 17-03-2017 IPR027363 Methylthioribose-1-phosphate isomerase-like, N-terminal domain KEGG: 00270+5.3.1.23|MetaCyc: PWY-4361|MetaCyc: PWY-7174|Reactome: R-HSA-1237112 SHXM_RS33010 6ce084ec26c524f29f009f277c479efb 341 Gene3D G3DSA:3.60.15.10 57 301 1.5E-30 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS33010 6ce084ec26c524f29f009f277c479efb 341 SUPERFAMILY SSF56281 69 201 1.13E-21 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS33010 6ce084ec26c524f29f009f277c479efb 341 SUPERFAMILY SSF56281 230 300 1.13E-21 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS33010 6ce084ec26c524f29f009f277c479efb 341 SMART SM00849 74 294 1.8E-9 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS33010 6ce084ec26c524f29f009f277c479efb 341 Pfam PF13483 Beta-lactamase superfamily domain 70 292 3.3E-12 T 17-03-2017 SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 157 173 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 Gene3D G3DSA:3.40.47.10 257 368 7.8E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 252 368 1.2E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 Gene3D G3DSA:3.40.47.10 1 256 8.4E-90 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 244 2.5E-88 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 SMART SM00825 Beta-ketoacyl synthase 1 368 1.1E-176 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05335 1c096283015f4c12fa9a48af142693ed 368 SUPERFAMILY SSF53901 1 359 9.35E-101 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 Gene3D G3DSA:2.30.40.10 3 63 3.0E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 Gene3D G3DSA:2.30.40.10 385 400 3.0E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 Gene3D G3DSA:3.20.20.140 64 384 5.1E-108 T 17-03-2017 SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 SUPERFAMILY SSF51556 61 376 1.63E-96 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 SUPERFAMILY SSF51338 376 449 3.95E-24 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 SUPERFAMILY SSF51338 4 61 3.95E-24 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS38960 b8f2f6838a37f675fdd65fefb92ca56e 456 Pfam PF01979 Amidohydrolase family 58 408 3.8E-63 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS02960 701750aaa2b9d21f1936441e362b4907 438 ProSitePatterns PS00216 Sugar transport proteins signature 1. 303 320 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS02960 701750aaa2b9d21f1936441e362b4907 438 ProSitePatterns PS00217 Sugar transport proteins signature 2. 131 156 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS02960 701750aaa2b9d21f1936441e362b4907 438 Gene3D G3DSA:1.20.1250.20 29 227 7.7E-21 T 17-03-2017 SHXM_RS02960 701750aaa2b9d21f1936441e362b4907 438 Gene3D G3DSA:1.20.1250.20 245 424 2.7E-26 T 17-03-2017 SHXM_RS02960 701750aaa2b9d21f1936441e362b4907 438 Pfam PF07690 Major Facilitator Superfamily 38 289 7.5E-25 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS02960 701750aaa2b9d21f1936441e362b4907 438 SUPERFAMILY SSF103473 16 430 6.41E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS38815 b4a9db37eab0f8918433a83a112ef1ac 342 SUPERFAMILY SSF48452 266 326 3.54E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS38815 b4a9db37eab0f8918433a83a112ef1ac 342 SUPERFAMILY SSF48452 99 217 3.54E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS38815 b4a9db37eab0f8918433a83a112ef1ac 342 Gene3D G3DSA:1.25.40.10 97 328 2.9E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS38815 b4a9db37eab0f8918433a83a112ef1ac 342 Pfam PF13424 Tetratricopeptide repeat 232 289 8.3E-8 T 17-03-2017 SHXM_RS49500 8a4cacfcfb2c9f6fd5961b3856d1df8e 359 PIRSF PIRSF007313 1 357 3.0E-85 T 17-03-2017 IPR008773 Phosphonate metabolism protein PhnI GO:0019634 SHXM_RS49500 8a4cacfcfb2c9f6fd5961b3856d1df8e 359 Pfam PF05861 Bacterial phosphonate metabolism protein (PhnI) 2 352 7.8E-86 T 17-03-2017 IPR008773 Phosphonate metabolism protein PhnI GO:0019634 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 SUPERFAMILY SSF142019 273 504 1.7E-86 T 17-03-2017 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 SUPERFAMILY SSF52833 46 168 7.72E-26 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 ProSitePatterns PS00645 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. 602 613 - T 17-03-2017 IPR001949 NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site GO:0008137|GO:0010181|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 Gene3D G3DSA:3.40.30.10 108 161 2.4E-4 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 SUPERFAMILY SSF140490 586 667 1.57E-22 T 17-03-2017 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 Pfam PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region 591 667 4.7E-21 T 17-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 Pfam PF10531 SLBB domain 507 537 2.8E-7 T 17-03-2017 IPR019554 Soluble ligand binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 Pfam PF01257 Thioredoxin-like [2Fe-2S] ferredoxin 50 161 4.7E-23 T 17-03-2017 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 Pfam PF01512 Respiratory-chain NADH dehydrogenase 51 Kd subunit 312 482 4.6E-51 T 17-03-2017 IPR011538 NADH-ubiquinone oxidoreductase 51 kDa subunit, FMN-binding domain Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 SUPERFAMILY SSF142984 505 584 8.24E-19 T 17-03-2017 SHXM_RS14240 7d21991497cbd82ad7383f8398e8ecd3 673 SMART SM00928 589 636 3.7E-17 T 17-03-2017 IPR019575 NADH-ubiquinone oxidoreductase 51 kDa subunit, iron-sulphur binding domain GO:0051539 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 PRINTS PR00297 10kDa chaperonin signature 10 25 2.3E-30 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 PRINTS PR00297 10kDa chaperonin signature 32 53 2.3E-30 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 PRINTS PR00297 10kDa chaperonin signature 66 78 2.3E-30 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 PRINTS PR00297 10kDa chaperonin signature 87 100 2.3E-30 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 Gene3D G3DSA:2.30.33.40 10 101 3.0E-36 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 SUPERFAMILY SSF50129 9 101 3.06E-32 T 17-03-2017 IPR011032 GroES-like SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 Pfam PF00166 Chaperonin 10 Kd subunit 10 100 2.4E-32 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 ProSitePatterns PS00681 Chaperonins cpn10 signature. 10 34 - T 17-03-2017 IPR018369 Chaperonin GroES, conserved site GO:0005524|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 Hamap MF_00580 10 kDa chaperonin [groS]. 9 101 25.329 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS31535 9804cb09dc9d721de4a689b00f500df9 102 SMART SM00883 9 100 2.5E-50 T 17-03-2017 IPR020818 GroES chaperonin family GO:0005737|GO:0006457 SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 Gene3D G3DSA:1.20.1250.20 15 221 8.4E-28 T 17-03-2017 SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 Gene3D G3DSA:1.20.1250.20 264 443 6.3E-24 T 17-03-2017 SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 ProSitePatterns PS00217 Sugar transport proteins signature 2. 132 157 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 Pfam PF07690 Major Facilitator Superfamily 269 447 4.3E-14 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 SUPERFAMILY SSF103473 17 444 1.2E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 ProSitePatterns PS00216 Sugar transport proteins signature 1. 311 328 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS06710 15fef9f07b1d5e40fb23f3e338d38573 465 Pfam PF00083 Sugar (and other) transporter 25 228 1.6E-25 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 Pfam PF00459 Inositol monophosphatase family 21 271 1.5E-15 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 Gene3D G3DSA:3.40.190.80 177 271 8.2E-17 T 17-03-2017 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 PRINTS PR00377 Inositol monophosphatase superfamily signature 215 239 4.3E-7 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 PRINTS PR00377 Inositol monophosphatase superfamily signature 181 202 4.3E-7 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 PRINTS PR00377 Inositol monophosphatase superfamily signature 96 112 4.3E-7 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 SUPERFAMILY SSF56655 19 271 1.7E-38 T 17-03-2017 SHXM_RS02470 7ccecec4a536239a9a3f851841cabdd1 276 Gene3D G3DSA:3.30.540.10 20 147 1.9E-17 T 17-03-2017 SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 Pfam PF01327 Polypeptide deformylase 19 164 1.7E-44 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 Gene3D G3DSA:3.90.45.10 15 178 1.2E-59 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 PIRSF PIRSF004749 7 181 1.6E-42 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 Hamap MF_00163 Peptide deformylase [def]. 12 175 28.58 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 20 168 3.8E-39 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 SUPERFAMILY SSF56420 11 171 8.11E-55 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 PRINTS PR01576 Peptide deformylase signature 43 72 2.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 PRINTS PR01576 Peptide deformylase signature 114 132 2.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 PRINTS PR01576 Peptide deformylase signature 133 162 2.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08390 44e970cf452b376e9f4be46cd4a7a7d4 185 PRINTS PR01576 Peptide deformylase signature 102 113 2.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS31375 bc6c6002d33495bc8a022803b78b8b4d 167 Pfam PF00380 Ribosomal protein S9/S16 46 167 7.1E-44 T 17-03-2017 IPR000754 Ribosomal protein S9 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31375 bc6c6002d33495bc8a022803b78b8b4d 167 Hamap MF_00532_B 30S ribosomal protein S9 [rpsI]. 37 167 33.233 T 17-03-2017 IPR023035 Ribosomal protein S9, bacterial/plastid SHXM_RS31375 bc6c6002d33495bc8a022803b78b8b4d 167 SUPERFAMILY SSF54211 43 167 2.92E-43 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS31375 bc6c6002d33495bc8a022803b78b8b4d 167 ProSitePatterns PS00360 Ribosomal protein S9 signature. 105 123 - T 17-03-2017 IPR020574 Ribosomal protein S9, conserved site GO:0003735|GO:0005840|GO:0006412 SHXM_RS31375 bc6c6002d33495bc8a022803b78b8b4d 167 Gene3D G3DSA:3.30.230.10 43 167 4.8E-48 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS42945 395a8beafc00705e7473ac5e144f1b2c 345 SUPERFAMILY SSF53807 35 342 3.14E-37 T 17-03-2017 SHXM_RS42945 395a8beafc00705e7473ac5e144f1b2c 345 Gene3D G3DSA:3.40.50.1980 51 193 1.2E-8 T 17-03-2017 SHXM_RS42945 395a8beafc00705e7473ac5e144f1b2c 345 Pfam PF01497 Periplasmic binding protein 54 318 6.5E-20 T 17-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SHXM_RS42945 395a8beafc00705e7473ac5e144f1b2c 345 Gene3D G3DSA:3.40.50.1980 203 341 5.2E-27 T 17-03-2017 SHXM_RS40785 a52cb0a08e85f47b7cedbd48ecd1314e 309 Pfam PF00704 Glycosyl hydrolases family 18 73 268 8.2E-17 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS40785 a52cb0a08e85f47b7cedbd48ecd1314e 309 PIRSF PIRSF001103 2 309 3.7E-138 T 17-03-2017 IPR016289 Endo-beta-N-acetylglucosaminidase GO:0005576|GO:0033925 KEGG: 00511+3.2.1.96 SHXM_RS40785 a52cb0a08e85f47b7cedbd48ecd1314e 309 ProSitePatterns PS01095 Chitinases family 18 active site. 162 170 - T 17-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS40785 a52cb0a08e85f47b7cedbd48ecd1314e 309 Gene3D G3DSA:3.20.20.80 42 307 6.1E-70 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS40785 a52cb0a08e85f47b7cedbd48ecd1314e 309 SUPERFAMILY SSF51445 42 284 6.9E-62 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SMART SM00028 386 419 0.42 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SMART SM00028 110 143 86.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SMART SM00028 214 247 0.5 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SMART SM00028 68 108 60.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SMART SM00028 177 210 290.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 Gene3D G3DSA:1.25.40.10 56 305 2.8E-30 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 Gene3D G3DSA:1.25.40.10 328 421 3.7E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SUPERFAMILY SSF48452 346 427 3.31E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SUPERFAMILY SSF48452 210 252 3.31E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 SUPERFAMILY SSF48452 84 305 1.2E-17 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS16535 66e1806b75ba8dd22cbc7c86d9daf98a 438 Pfam PF13432 Tetratricopeptide repeat 219 279 5.1E-6 T 17-03-2017 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 248 259 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 220 227 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 SUPERFAMILY SSF53720 12 440 4.06E-121 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 Gene3D G3DSA:3.40.605.10 4 234 1.5E-58 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 Gene3D G3DSA:3.40.309.10 235 419 2.8E-62 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 PIRSF PIRSF036492 2 445 2.8E-177 T 17-03-2017 IPR012394 Aldehyde dehydrogenase NAD(P)-dependent GO:0004030|GO:0006081|GO:0055114 SHXM_RS42335 6b89fde7d3ca6a7194f452e4331c7f29 445 Pfam PF00171 Aldehyde dehydrogenase family 3 439 3.6E-87 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS29710 54edce66266a67ae419bafb3243a064c 396 Pfam PF01551 Peptidase family M23 291 385 6.7E-25 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS29710 54edce66266a67ae419bafb3243a064c 396 SUPERFAMILY SSF51261 220 389 1.83E-41 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS29710 54edce66266a67ae419bafb3243a064c 396 PRINTS PR01852 Streptococcal non-M secreted SibA protein signature 234 261 1.5E-5 T 17-03-2017 IPR009148 Streptococcal non-M secreted SibA SHXM_RS29710 54edce66266a67ae419bafb3243a064c 396 PRINTS PR01852 Streptococcal non-M secreted SibA protein signature 303 325 1.5E-5 T 17-03-2017 IPR009148 Streptococcal non-M secreted SibA SHXM_RS29710 54edce66266a67ae419bafb3243a064c 396 Gene3D G3DSA:2.70.70.10 241 391 2.8E-41 T 17-03-2017 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 Pfam PF03900 Porphobilinogen deaminase, C-terminal domain 239 316 1.3E-16 T 17-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 Hamap MF_00260 Porphobilinogen deaminase [hemC]. 15 318 34.497 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 PRINTS PR00151 Porphobilinogen deaminase signature 242 259 5.2E-20 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 PRINTS PR00151 Porphobilinogen deaminase signature 53 73 5.2E-20 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 PRINTS PR00151 Porphobilinogen deaminase signature 155 172 5.2E-20 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 PRINTS PR00151 Porphobilinogen deaminase signature 84 103 5.2E-20 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 ProSitePatterns PS00533 Porphobilinogen deaminase cofactor-binding site. 243 259 - T 17-03-2017 IPR022419 Porphobilinogen deaminase, dipyrromethane cofactor binding site GO:0004418|GO:0018160|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 Gene3D G3DSA:3.40.190.10 119 211 7.5E-31 T 17-03-2017 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 TIGRFAM TIGR00212 hemC: hydroxymethylbilane synthase 16 318 2.4E-84 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 SUPERFAMILY SSF54782 232 326 3.92E-18 T 17-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 Gene3D G3DSA:3.30.160.40 233 325 5.9E-23 T 17-03-2017 IPR022418 Porphobilinogen deaminase, C-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 Pfam PF01379 Porphobilinogen deaminase, dipyromethane cofactor binding domain 16 221 2.2E-66 T 17-03-2017 IPR022417 Porphobilinogen deaminase, N-terminal GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 Gene3D G3DSA:3.40.190.10 15 118 1.3E-38 T 17-03-2017 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 PIRSF PIRSF001438 3 329 3.0E-108 T 17-03-2017 IPR000860 Porphobilinogen deaminase GO:0004418|GO:0033014 KEGG: 00860+2.5.1.61|MetaCyc: PWY-5188|MetaCyc: PWY-5189|Reactome: R-HSA-189451 SHXM_RS30465 85fd410ccc10f328675729991d191ce3 329 SUPERFAMILY SSF53850 15 229 2.54E-64 T 17-03-2017 SHXM_RS33140 191abe3954734a481fad4dbd3a0ecbfc 111 Gene3D G3DSA:3.30.70.900 3 107 4.8E-18 T 17-03-2017 SHXM_RS33140 191abe3954734a481fad4dbd3a0ecbfc 111 TIGRFAM TIGR02118 TIGR02118: conserved hypothetical protein 4 108 6.5E-13 T 17-03-2017 IPR009799 EthD domain SHXM_RS33140 191abe3954734a481fad4dbd3a0ecbfc 111 Pfam PF07110 EthD domain 13 97 1.4E-19 T 17-03-2017 IPR009799 EthD domain SHXM_RS33140 191abe3954734a481fad4dbd3a0ecbfc 111 SUPERFAMILY SSF54909 2 110 3.52E-29 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 PIRSF PIRSF002599 1 67 7.2E-26 T 17-03-2017 IPR012156 Cold shock, CspA GO:0003676 SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 SMART SM00357 3 67 2.3E-31 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 Gene3D G3DSA:2.40.50.140 1 65 1.3E-31 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 PRINTS PR00050 Cold shock protein signature 25 34 6.3E-18 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 PRINTS PR00050 Cold shock protein signature 4 19 6.3E-18 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 PRINTS PR00050 Cold shock protein signature 40 58 6.3E-18 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 SUPERFAMILY SSF50249 1 66 1.24E-25 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS30705 a8da0b9711ceec6fd1ac9df299f5af1e 67 Pfam PF00313 'Cold-shock' DNA-binding domain 3 66 1.7E-31 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 SUPERFAMILY SSF52540 16 263 7.17E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 ProSitePatterns PS00211 ABC transporters family signature. 164 178 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 665 695 6.3E-4 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 243 273 2.2E-7 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 SUPERFAMILY SSF52540 445 685 6.48E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 ProSitePatterns PS00211 ABC transporters family signature. 586 600 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 Pfam PF00005 ABC transporter 468 613 1.7E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 Pfam PF00005 ABC transporter 35 191 4.9E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 SMART SM00382 43 248 2.1E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 SMART SM00382 476 678 7.8E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 Gene3D G3DSA:3.40.50.300 444 687 6.2E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06040 7a76324af3b84e88001393cbccb4d615 696 Gene3D G3DSA:3.40.50.300 15 265 1.5E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26255 c671f0b6bfb05f9f6309f5d3394e8f8d 283 Pfam PF13560 Helix-turn-helix domain 13 76 1.8E-10 T 17-03-2017 SHXM_RS26255 c671f0b6bfb05f9f6309f5d3394e8f8d 283 SUPERFAMILY SSF47413 11 75 1.42E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26255 c671f0b6bfb05f9f6309f5d3394e8f8d 283 Gene3D G3DSA:1.10.260.40 3 74 7.3E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26255 c671f0b6bfb05f9f6309f5d3394e8f8d 283 SMART SM00530 17 72 7.5E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS13930 5c7aaf48df8a0e9ff2ee840cdb98a888 684 Pfam PF14508 Glycosyl-hydrolase 97 N-terminal 45 294 4.4E-66 T 17-03-2017 IPR029486 Glycosyl-hydrolase 97, N-terminal domain SHXM_RS13930 5c7aaf48df8a0e9ff2ee840cdb98a888 684 Pfam PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation 583 679 5.9E-28 T 17-03-2017 IPR029483 Glycosyl-hydrolase 97, C-terminal oligomerisation domain SHXM_RS13930 5c7aaf48df8a0e9ff2ee840cdb98a888 684 Pfam PF10566 Glycoside hydrolase 97 299 580 5.8E-93 T 17-03-2017 IPR019563 Glycosyl-hydrolase 97, catalytic domain SHXM_RS13930 5c7aaf48df8a0e9ff2ee840cdb98a888 684 SUPERFAMILY SSF51445 298 566 1.94E-10 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS18210 f7120476a93f924a5c94efeeb6c02747 470 Gene3D G3DSA:3.40.640.10 101 362 1.8E-69 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS18210 f7120476a93f924a5c94efeeb6c02747 470 SUPERFAMILY SSF53383 64 464 8.44E-87 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS18210 f7120476a93f924a5c94efeeb6c02747 470 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 80 408 3.7E-38 T 17-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 SHXM_RS18210 f7120476a93f924a5c94efeeb6c02747 470 Gene3D G3DSA:3.90.1150.10 363 466 9.0E-32 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS10155 7b651db22f92a1e1b06a820bc1dd5712 335 SUPERFAMILY SSF53041 91 238 7.46E-25 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS10155 7b651db22f92a1e1b06a820bc1dd5712 335 Gene3D G3DSA:3.40.50.1390 92 222 8.7E-23 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS10155 7b651db22f92a1e1b06a820bc1dd5712 335 SMART SM00857 91 238 3.6E-27 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS10155 7b651db22f92a1e1b06a820bc1dd5712 335 Pfam PF00239 Resolvase, N terminal domain 92 238 1.3E-27 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 Gene3D G3DSA:3.20.20.140 63 358 4.7E-103 T 17-03-2017 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 Pfam PF01979 Amidohydrolase family 59 388 8.1E-30 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 TIGRFAM TIGR00221 nagA: N-acetylglucosamine-6-phosphate deacetylase 3 384 5.6E-82 T 17-03-2017 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395|Reactome: R-HSA-446210 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 Gene3D G3DSA:2.30.40.10 359 375 1.8E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 Gene3D G3DSA:2.30.40.10 3 62 1.8E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 SUPERFAMILY SSF51556 62 359 6.81E-91 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 PIRSF PIRSF038994 3 391 1.1E-110 T 17-03-2017 IPR003764 N-acetylglucosamine-6-phosphate deacetylase GO:0006044|GO:0008448 KEGG: 00052+3.5.1.25|KEGG: 00520+3.5.1.25|MetaCyc: PWY-6906|MetaCyc: PWY-7077|MetaCyc: PWY-7395|Reactome: R-HSA-446210 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 SUPERFAMILY SSF51338 2 62 2.82E-17 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS25895 c70543884d6a131c8f76e58fb581ce04 394 SUPERFAMILY SSF51338 359 377 2.82E-17 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 Pfam PF00582 Universal stress protein family 4 136 5.2E-21 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 Pfam PF00582 Universal stress protein family 156 290 2.2E-15 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 PRINTS PR01438 Universal stress protein signature 268 290 1.4E-10 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 PRINTS PR01438 Universal stress protein signature 250 262 1.4E-10 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 PRINTS PR01438 Universal stress protein signature 2 20 1.4E-10 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 SUPERFAMILY SSF52402 5 137 5.27E-26 T 17-03-2017 SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 Gene3D G3DSA:3.40.50.620 1 136 1.7E-28 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 Gene3D G3DSA:3.40.50.620 152 290 6.1E-25 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS27350 8fd12e84f98e207736188e6c86e4865b 294 SUPERFAMILY SSF52402 156 292 5.27E-23 T 17-03-2017 SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 Pfam PF13560 Helix-turn-helix domain 18 75 1.7E-14 T 17-03-2017 SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 SUPERFAMILY SSF51182 61 195 4.46E-26 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 SMART SM00530 21 76 6.6E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 Pfam PF07883 Cupin domain 127 190 6.7E-14 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 SUPERFAMILY SSF47413 17 81 6.17E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 Gene3D G3DSA:1.10.260.40 18 118 2.7E-23 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04040 93fa514d9de7c0adbd2eef08ff7bbfc1 196 Gene3D G3DSA:2.60.120.10 119 195 2.2E-21 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS40735 36410ec6f8522a59c7735afd28f69e4b 134 Gene3D G3DSA:3.10.450.50 3 109 5.0E-9 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS40735 36410ec6f8522a59c7735afd28f69e4b 134 SUPERFAMILY SSF54427 5 124 1.32E-22 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS44960 1094616b6ed60f55a8be4cdf2fe7fdd2 129 Pfam PF01479 S4 domain 8 54 2.0E-12 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS44960 1094616b6ed60f55a8be4cdf2fe7fdd2 129 SMART SM00363 8 75 1.6E-9 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS44960 1094616b6ed60f55a8be4cdf2fe7fdd2 129 SUPERFAMILY SSF55174 7 90 1.57E-22 T 17-03-2017 SHXM_RS44960 1094616b6ed60f55a8be4cdf2fe7fdd2 129 PIRSF PIRSF016821 5 126 4.7E-45 T 17-03-2017 IPR025708 Heat shock protein 15 GO:0003677|GO:0003727|GO:0034605|GO:0043023 SHXM_RS44960 1094616b6ed60f55a8be4cdf2fe7fdd2 129 Gene3D G3DSA:3.10.290.10 7 96 2.9E-29 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS16600 a5e5f7fbdc3eeceb2287dcd40226e2f9 126 SUPERFAMILY SSF46785 13 82 1.21E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16600 a5e5f7fbdc3eeceb2287dcd40226e2f9 126 Gene3D G3DSA:1.10.10.10 6 79 4.6E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16600 a5e5f7fbdc3eeceb2287dcd40226e2f9 126 Pfam PF00392 Bacterial regulatory proteins, gntR family 17 78 4.0E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16600 a5e5f7fbdc3eeceb2287dcd40226e2f9 126 SMART SM00345 19 78 4.3E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS40865 16c6e503ee099b4dbb61a43a0665c2a4 417 Gene3D G3DSA:1.20.1250.20 229 396 1.1E-11 T 17-03-2017 SHXM_RS40865 16c6e503ee099b4dbb61a43a0665c2a4 417 Pfam PF07690 Major Facilitator Superfamily 18 356 3.6E-16 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS40865 16c6e503ee099b4dbb61a43a0665c2a4 417 Gene3D G3DSA:1.20.1250.20 17 177 2.6E-15 T 17-03-2017 SHXM_RS40865 16c6e503ee099b4dbb61a43a0665c2a4 417 SUPERFAMILY SSF103473 8 394 1.07E-34 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS34760 0067772954c7cf0e4ddffa6da2f206c8 313 Gene3D G3DSA:1.10.3720.10 64 281 2.6E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34760 0067772954c7cf0e4ddffa6da2f206c8 313 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 68 176 1.5E-18 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS34760 0067772954c7cf0e4ddffa6da2f206c8 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 87 278 2.5E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34760 0067772954c7cf0e4ddffa6da2f206c8 313 SUPERFAMILY SSF161098 67 267 1.44E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45415 08445b484860884118098691506824f4 262 Gene3D G3DSA:2.60.120.200 113 212 3.4E-4 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS45415 08445b484860884118098691506824f4 262 SUPERFAMILY SSF49899 114 242 1.08E-5 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS23895 76ce8dc96c1768eacbd468efa850563b 293 Gene3D G3DSA:1.10.3720.10 25 281 1.2E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23895 76ce8dc96c1768eacbd468efa850563b 293 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 104 277 4.3E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23895 76ce8dc96c1768eacbd468efa850563b 293 SUPERFAMILY SSF161098 25 293 2.09E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04760 f9120cc9298f1d6837d593d23bbf6b92 464 SUPERFAMILY SSF52777 4 205 1.33E-34 T 17-03-2017 SHXM_RS04760 f9120cc9298f1d6837d593d23bbf6b92 464 Pfam PF00668 Condensation domain 6 303 1.3E-32 T 17-03-2017 IPR001242 Condensation domain SHXM_RS04760 f9120cc9298f1d6837d593d23bbf6b92 464 SUPERFAMILY SSF52777 192 456 7.56E-26 T 17-03-2017 SHXM_RS01810 b17480880595dd48e0233b4e14d55e19 323 Gene3D G3DSA:1.10.3720.10 26 309 8.4E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01810 b17480880595dd48e0233b4e14d55e19 323 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 307 4.1E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01810 b17480880595dd48e0233b4e14d55e19 323 SUPERFAMILY SSF161098 77 306 1.27E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45265 04e09492ce5beb89539d445a51fb5ee5 649 Pfam PF04865 Baseplate J-like protein 389 564 2.7E-9 T 17-03-2017 IPR006949 Baseplate protein J-like SHXM_RS45265 04e09492ce5beb89539d445a51fb5ee5 649 TIGRFAM TIGR02243 TIGR02243: putative baseplate assembly protein 8 594 2.0E-61 T 17-03-2017 IPR011749 Conserved hypothetical protein CHP02243 SHXM_RS20630 778e7f3b20f91ae05dbcd7ef31e21950 328 Pfam PF00962 Adenosine/AMP deaminase 4 320 8.0E-71 T 17-03-2017 IPR001365 Adenosine/AMP deaminase domain GO:0019239 Reactome: R-HSA-74217 SHXM_RS20630 778e7f3b20f91ae05dbcd7ef31e21950 328 SUPERFAMILY SSF51556 5 320 2.32E-82 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS20630 778e7f3b20f91ae05dbcd7ef31e21950 328 Hamap MF_01962 Adenine deaminase. 3 312 80.847 T 17-03-2017 IPR028892 Adenine deaminase type 2 GO:0000034|GO:0006146 KEGG: 00230+3.5.4.2|MetaCyc: PWY-6610 SHXM_RS20630 778e7f3b20f91ae05dbcd7ef31e21950 328 Gene3D G3DSA:3.20.20.140 4 325 7.0E-99 T 17-03-2017 SHXM_RS20630 778e7f3b20f91ae05dbcd7ef31e21950 328 TIGRFAM TIGR01430 aden_deam: adenosine deaminase 5 323 1.1E-114 T 17-03-2017 IPR006330 Adenosine/adenine deaminase GO:0019239 Reactome: R-HSA-74217 SHXM_RS47005 c627ec368430879ac2614aa91e018b81 61 Pfam PF00107 Zinc-binding dehydrogenase 1 41 1.5E-8 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS47005 c627ec368430879ac2614aa91e018b81 61 Gene3D G3DSA:3.40.50.720 1 37 7.3E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47005 c627ec368430879ac2614aa91e018b81 61 SUPERFAMILY SSF51735 1 50 2.93E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50965 b5f2aab04f262c31e97087bd7efbaab3 352 SUPERFAMILY SSF52540 61 116 9.84E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50965 b5f2aab04f262c31e97087bd7efbaab3 352 SUPERFAMILY SSF52540 151 322 9.84E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50965 b5f2aab04f262c31e97087bd7efbaab3 352 Gene3D G3DSA:3.40.50.300 102 137 5.4E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50965 b5f2aab04f262c31e97087bd7efbaab3 352 Gene3D G3DSA:3.40.50.300 178 203 5.4E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50965 b5f2aab04f262c31e97087bd7efbaab3 352 Gene3D G3DSA:3.40.50.300 60 101 4.1E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50965 b5f2aab04f262c31e97087bd7efbaab3 352 Pfam PF05621 Bacterial TniB protein 67 318 3.2E-24 T 17-03-2017 IPR008868 Bacterial TniB SHXM_RS29630 1829a97ad6ef51c1359ec8d352e89bcb 404 Pfam PF00589 Phage integrase family 206 387 1.4E-23 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS29630 1829a97ad6ef51c1359ec8d352e89bcb 404 SUPERFAMILY SSF56349 157 396 8.54E-69 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS29630 1829a97ad6ef51c1359ec8d352e89bcb 404 SUPERFAMILY SSF56349 72 130 8.54E-69 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS29630 1829a97ad6ef51c1359ec8d352e89bcb 404 Gene3D G3DSA:1.10.150.130 72 198 9.6E-18 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS29630 1829a97ad6ef51c1359ec8d352e89bcb 404 Gene3D G3DSA:1.10.443.10 206 395 2.1E-45 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS29630 1829a97ad6ef51c1359ec8d352e89bcb 404 Pfam PF14659 Phage integrase, N-terminal SAM-like domain 72 128 8.3E-10 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS47015 7febb3a9c186065075e408e450b3cb86 627 Pfam PF00005 ABC transporter 402 554 3.1E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS47015 7febb3a9c186065075e408e450b3cb86 627 Gene3D G3DSA:3.40.50.300 384 614 2.3E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47015 7febb3a9c186065075e408e450b3cb86 627 SUPERFAMILY SSF52540 376 622 9.96E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47015 7febb3a9c186065075e408e450b3cb86 627 SMART SM00382 410 608 9.6E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS47015 7febb3a9c186065075e408e450b3cb86 627 SUPERFAMILY SSF90123 50 348 1.96E-10 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS05865 39cd8af8e3bf48681654d81afca7961b 615 Pfam PF04984 Phage tail sheath protein 8 608 3.1E-46 T 17-03-2017 IPR007067 Tail sheath protein SHXM_RS26930 2f3b8a5eaab924097e30203ea24920f7 369 Gene3D G3DSA:3.40.50.300 132 343 2.7E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26930 2f3b8a5eaab924097e30203ea24920f7 369 Pfam PF01656 CobQ/CobB/MinD/ParA nucleotide binding domain 135 293 2.8E-10 T 17-03-2017 IPR002586 CobQ/CobB/MinD/ParA nucleotide binding domain SHXM_RS26930 2f3b8a5eaab924097e30203ea24920f7 369 SUPERFAMILY SSF52540 132 342 2.95E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26930 2f3b8a5eaab924097e30203ea24920f7 369 TIGRFAM TIGR03815 CpaE_hom_Actino: helicase/secretion neighborhood CpaE-like protein 23 356 4.9E-106 T 17-03-2017 IPR022521 Conserved hypothetical protein CHP03815, CpaE-like SHXM_RS27620 8218ec726b4680229af3c28dddb33ebb 224 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 25 189 3.2E-17 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS27620 8218ec726b4680229af3c28dddb33ebb 224 SMART SM00943 25 198 1.2E-18 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 Pfam PF13377 Periplasmic binding protein-like domain 189 348 6.6E-30 T 17-03-2017 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 SUPERFAMILY SSF47413 19 77 1.13E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 SUPERFAMILY SSF53822 98 353 9.6E-37 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 Pfam PF00356 Bacterial regulatory proteins, lacI family 22 66 1.6E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 SMART SM00354 19 89 4.6E-21 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 Gene3D G3DSA:1.10.260.40 21 75 7.0E-24 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 Gene3D G3DSA:3.40.50.2300 76 186 7.5E-10 T 17-03-2017 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 Gene3D G3DSA:3.40.50.2300 187 349 2.1E-34 T 17-03-2017 SHXM_RS27810 706428a5c3e102a056843e0facdb644f 366 ProSitePatterns PS00356 LacI-type HTH domain signature. 22 40 - T 17-03-2017 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 Gene3D G3DSA:3.40.47.10 24 126 5.8E-8 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 Gene3D G3DSA:3.40.47.10 210 237 5.8E-8 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 SUPERFAMILY SSF53901 21 240 2.45E-16 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 PIRSF PIRSF000429 15 389 5.1E-19 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 Gene3D G3DSA:3.40.47.10 258 346 2.6E-4 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 Gene3D G3DSA:3.40.47.10 157 194 2.6E-4 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS31805 20fd71267eaeb82a4ba37e888c633ca1 394 SUPERFAMILY SSF53901 263 366 5.97E-13 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS13755 8549ab1deac3efc4a537e4bbe74cdb04 554 TIGRFAM TIGR00680 kdpA: K+-transporting ATPase, A subunit 5 553 1.8E-204 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS13755 8549ab1deac3efc4a537e4bbe74cdb04 554 PIRSF PIRSF001294 4 554 2.3E-216 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS13755 8549ab1deac3efc4a537e4bbe74cdb04 554 Hamap MF_00275 Potassium-transporting ATPase potassium-binding subunit [kdpA]. 4 554 31.935 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS13755 8549ab1deac3efc4a537e4bbe74cdb04 554 Pfam PF03814 Potassium-transporting ATPase A subunit 14 553 8.7E-225 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS50000 6ab6afa51afc751ec9168041338e9687 438 SUPERFAMILY SSF56059 119 334 5.21E-20 T 17-03-2017 SHXM_RS50000 6ab6afa51afc751ec9168041338e9687 438 Gene3D G3DSA:3.30.470.20 117 423 2.6E-10 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS50000 6ab6afa51afc751ec9168041338e9687 438 Pfam PF13535 ATP-grasp domain 161 307 2.8E-12 T 17-03-2017 SHXM_RS13195 f94e9feabb2ca66da986115514117bd9 462 Pfam PF00171 Aldehyde dehydrogenase family 10 455 6.1E-163 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS13195 f94e9feabb2ca66da986115514117bd9 462 Gene3D G3DSA:3.40.309.10 250 435 9.0E-59 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS13195 f94e9feabb2ca66da986115514117bd9 462 Gene3D G3DSA:3.40.605.10 9 249 2.8E-94 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS13195 f94e9feabb2ca66da986115514117bd9 462 SUPERFAMILY SSF53720 8 457 1.24E-155 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS13195 f94e9feabb2ca66da986115514117bd9 462 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 263 274 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS13195 f94e9feabb2ca66da986115514117bd9 462 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 235 242 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS13880 5614c9374fae1bcdbe81ee8c20d759a7 186 Pfam PF13302 Acetyltransferase (GNAT) domain 9 151 9.0E-31 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS13880 5614c9374fae1bcdbe81ee8c20d759a7 186 SUPERFAMILY SSF55729 2 162 3.88E-38 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS13880 5614c9374fae1bcdbe81ee8c20d759a7 186 Gene3D G3DSA:3.40.630.30 2 184 8.4E-48 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS20125 5096e34a402b3fb75ee06346987691ac 74 Gene3D G3DSA:2.40.50.140 1 70 4.0E-9 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS20125 5096e34a402b3fb75ee06346987691ac 74 SUPERFAMILY SSF50249 1 54 2.14E-5 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS45495 ab5e2b7ffe786e61e9ed841d2121d5c6 203 SUPERFAMILY SSF48498 85 188 4.89E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS45495 ab5e2b7ffe786e61e9ed841d2121d5c6 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 34 64 4.8E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45495 ab5e2b7ffe786e61e9ed841d2121d5c6 203 Gene3D G3DSA:1.10.357.10 8 191 2.9E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS45495 ab5e2b7ffe786e61e9ed841d2121d5c6 203 SUPERFAMILY SSF46689 10 80 4.24E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02855 af6964e42c2e788cc3153584e2d15076 264 Pfam PF01261 Xylose isomerase-like TIM barrel 21 220 2.7E-37 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS02855 af6964e42c2e788cc3153584e2d15076 264 SUPERFAMILY SSF51658 1 259 4.19E-83 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS02855 af6964e42c2e788cc3153584e2d15076 264 PIRSF PIRSF006241 1 263 2.3E-95 T 17-03-2017 IPR026040 Hydroxypyruvate isomerase-like KEGG: 00630+5.3.1.22 SHXM_RS02855 af6964e42c2e788cc3153584e2d15076 264 Gene3D G3DSA:3.20.20.150 1 259 2.6E-91 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 SUPERFAMILY SSF51905 17 182 1.65E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 SUPERFAMILY SSF51905 282 386 1.65E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 161 176 2.2E-8 T 17-03-2017 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 295 310 2.2E-8 T 17-03-2017 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 17 39 2.2E-8 T 17-03-2017 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 Gene3D G3DSA:3.50.50.60 16 188 6.1E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 Gene3D G3DSA:3.50.50.60 283 359 6.1E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16660 b894d06b736a44398685955de82b2e3a 407 Pfam PF01494 FAD binding domain 17 348 5.0E-13 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS11775 a3ffdfc298a59857ca011dca4734c574 177 Pfam PF13305 WHG domain 74 151 6.5E-12 T 17-03-2017 IPR025996 WHG domain SHXM_RS11775 a3ffdfc298a59857ca011dca4734c574 177 Gene3D G3DSA:1.10.357.10 48 175 1.2E-37 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS11775 a3ffdfc298a59857ca011dca4734c574 177 Gene3D G3DSA:1.10.10.60 1 47 7.9E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11775 a3ffdfc298a59857ca011dca4734c574 177 Pfam PF00440 Bacterial regulatory proteins, tetR family 3 43 2.3E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11775 a3ffdfc298a59857ca011dca4734c574 177 SUPERFAMILY SSF48498 68 174 4.45E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11775 a3ffdfc298a59857ca011dca4734c574 177 SUPERFAMILY SSF46689 2 63 2.05E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35630 9a00fce482346859ba2cde0c04a7813f 301 Gene3D G3DSA:3.40.50.720 4 234 3.6E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35630 9a00fce482346859ba2cde0c04a7813f 301 Pfam PF05368 NmrA-like family 10 239 1.1E-48 T 17-03-2017 IPR008030 NmrA-like domain Reactome: R-HSA-70635 SHXM_RS35630 9a00fce482346859ba2cde0c04a7813f 301 SUPERFAMILY SSF51735 6 250 7.09E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15455 28f17fdf8db75277ca719e8633170277 335 SUPERFAMILY SSF53383 6 313 4.79E-27 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS15455 28f17fdf8db75277ca719e8633170277 335 Gene3D G3DSA:3.40.640.10 35 219 6.0E-14 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS15455 28f17fdf8db75277ca719e8633170277 335 Pfam PF00155 Aminotransferase class I and II 35 227 4.8E-8 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 225 382 5.7E-19 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 SUPERFAMILY SSF56645 16 238 1.44E-64 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 Gene3D G3DSA:1.20.140.10 215 391 6.1E-27 T 17-03-2017 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 13 115 1.4E-9 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 Gene3D G3DSA:2.40.110.10 118 214 1.1E-34 T 17-03-2017 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 SUPERFAMILY SSF47203 225 384 1.69E-16 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 Gene3D G3DSA:1.10.540.10 16 116 6.6E-17 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS45035 4b8912c9036a7d8c9d55f2d16fba0b21 401 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 119 202 1.8E-20 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS43695 a540595f4945e4f6b34015c18dd542dd 222 SUPERFAMILY SSF50891 83 205 1.86E-40 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS43695 a540595f4945e4f6b34015c18dd542dd 222 Gene3D G3DSA:2.40.100.10 83 205 7.8E-47 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS43695 a540595f4945e4f6b34015c18dd542dd 222 SMART SM00796 3 194 3.6E-71 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS43695 a540595f4945e4f6b34015c18dd542dd 222 Pfam PF02682 Allophanate hydrolase subunit 1 4 193 1.3E-57 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS29720 a72cdd6908e4f5b91b73ebd511d8e10e 146 Pfam PF03852 DNA mismatch endonuclease Vsr 12 74 4.6E-12 T 17-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SHXM_RS29720 a72cdd6908e4f5b91b73ebd511d8e10e 146 Gene3D G3DSA:3.40.960.10 22 136 3.4E-40 T 17-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SHXM_RS29720 a72cdd6908e4f5b91b73ebd511d8e10e 146 SUPERFAMILY SSF52980 8 133 2.79E-37 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS29720 a72cdd6908e4f5b91b73ebd511d8e10e 146 TIGRFAM TIGR00632 vsr: DNA mismatch endonuclease Vsr 12 121 1.8E-32 T 17-03-2017 IPR004603 DNA mismatch endonuclease vsr GO:0004519|GO:0006298 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 Pfam PF01145 SPFH domain / Band 7 family 26 196 6.9E-33 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 175 196 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 200 223 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 29 51 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 156 174 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 77 98 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 132 155 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 PRINTS PR00721 Stomatin signature 112 129 4.7E-60 T 17-03-2017 IPR001972 Stomatin family GO:0016020 SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 SUPERFAMILY SSF117892 55 187 1.24E-40 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS16895 415ba30ffc8955225b01f0eb85e00ff4 314 SMART SM00244 22 180 7.5E-62 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 Gene3D G3DSA:1.10.10.60 336 383 5.1E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 Pfam PF01965 DJ-1/PfpI family 76 242 1.4E-17 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 Gene3D G3DSA:3.40.50.880 77 275 1.3E-49 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 SUPERFAMILY SSF52317 76 263 3.56E-46 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 SMART SM00342 297 380 4.9E-27 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 Gene3D G3DSA:1.10.10.60 287 335 9.3E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 SUPERFAMILY SSF46689 287 331 5.73E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 Pfam PF12833 Helix-turn-helix domain 303 381 9.6E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS41360 62096218af67b1570b5413d042d1ce24 401 SUPERFAMILY SSF46689 334 384 1.97E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 Gene3D G3DSA:1.10.260.40 13 84 2.1E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 Pfam PF07883 Cupin domain 111 180 3.3E-12 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 Pfam PF13560 Helix-turn-helix domain 16 73 3.0E-14 T 17-03-2017 SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 SUPERFAMILY SSF51182 69 179 5.35E-23 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 Gene3D G3DSA:2.60.120.10 91 181 1.0E-13 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 SUPERFAMILY SSF47413 9 80 5.63E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS45430 6527d4ca2750af4bdfe3e14978465bc9 195 SMART SM00530 18 73 1.6E-13 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS23200 dc5fe713cd3481edbc6f1795ff419478 197 SUPERFAMILY SSF81296 29 197 1.82E-60 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS23200 dc5fe713cd3481edbc6f1795ff419478 197 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 29 195 6.9E-42 T 17-03-2017 IPR004302 Chitin-binding protein, N-terminal SHXM_RS23200 dc5fe713cd3481edbc6f1795ff419478 197 Gene3D G3DSA:2.70.50.50 29 197 1.7E-65 T 17-03-2017 SHXM_RS01020 367b3be9724ba5c9453eb832a6df3034 319 Pfam PF02653 Branched-chain amino acid transport system / permease component 40 304 2.6E-50 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 Gene3D G3DSA:3.40.50.150 248 441 6.9E-50 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 SUPERFAMILY SSF53335 75 442 3.52E-55 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 Pfam PF01938 TRAM domain 8 67 3.6E-14 T 17-03-2017 IPR002792 TRAM domain SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 Gene3D G3DSA:2.40.50.140 10 85 2.4E-22 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 286 349 6.7E-5 T 17-03-2017 SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 Pfam PF05958 tRNA (Uracil-5-)-methyltransferase 368 441 1.6E-9 T 17-03-2017 IPR010280 (Uracil-5)-methyltransferase family GO:0006396|GO:0008173 SHXM_RS37705 7b579130bd0326712d9a4d386304b39e 447 SUPERFAMILY SSF50249 9 56 6.85E-10 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 Pfam PF00205 Thiamine pyrophosphate enzyme, central domain 226 302 4.4E-7 T 17-03-2017 IPR012000 Thiamine pyrophosphate enzyme, central domain GO:0000287|GO:0030976 SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 Gene3D G3DSA:3.40.50.970 395 608 1.3E-45 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 441 578 2.1E-13 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 SUPERFAMILY SSF52518 399 608 4.42E-28 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 Pfam PF02776 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain 9 183 6.2E-35 T 17-03-2017 IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain GO:0030976 SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 SUPERFAMILY SSF52518 7 194 1.28E-33 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 Gene3D G3DSA:3.40.50.970 7 186 1.7E-50 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 SUPERFAMILY SSF52467 199 346 1.13E-11 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS42065 c951d42706840233f170f0aa930ac542 614 Gene3D G3DSA:3.40.50.1220 224 349 1.6E-22 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS16475 dbf9552436305905f865c3eb94827639 260 Gene3D G3DSA:3.20.10.10 120 243 1.5E-18 T 17-03-2017 SHXM_RS16475 dbf9552436305905f865c3eb94827639 260 Gene3D G3DSA:3.30.470.10 20 107 1.6E-7 T 17-03-2017 SHXM_RS16475 dbf9552436305905f865c3eb94827639 260 Pfam PF01063 Amino-transferase class IV 23 233 1.9E-33 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS16475 dbf9552436305905f865c3eb94827639 260 SUPERFAMILY SSF56752 11 241 3.79E-41 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS46735 d4deaf872d49c48d9b57b45a95ddd807 351 SUPERFAMILY SSF53807 54 344 2.08E-50 T 17-03-2017 SHXM_RS46735 d4deaf872d49c48d9b57b45a95ddd807 351 Pfam PF01497 Periplasmic binding protein 106 317 8.5E-28 T 17-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SHXM_RS46735 d4deaf872d49c48d9b57b45a95ddd807 351 Gene3D G3DSA:3.40.50.1980 189 345 1.7E-19 T 17-03-2017 SHXM_RS46735 d4deaf872d49c48d9b57b45a95ddd807 351 Gene3D G3DSA:3.40.50.1980 52 188 5.5E-27 T 17-03-2017 SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 Pfam PF09339 IclR helix-turn-helix domain 14 62 9.2E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 Gene3D G3DSA:3.30.450.40 82 259 3.1E-47 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 Pfam PF01614 Bacterial transcriptional regulator 130 254 6.5E-27 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 SUPERFAMILY SSF55781 78 258 1.77E-41 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 SUPERFAMILY SSF46785 14 84 7.09E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 Gene3D G3DSA:1.10.10.10 12 81 1.3E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41935 1036cdf193a4b770ea0ffcc82300350f 263 SMART SM00346 12 102 4.4E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 SMART SM00345 34 92 1.5E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 SMART SM00895 102 227 1.5E-12 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 Gene3D G3DSA:1.10.10.10 20 93 9.5E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 SUPERFAMILY SSF48008 99 226 7.59E-19 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 Pfam PF07729 FCD domain 102 225 3.1E-18 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 Gene3D G3DSA:1.20.120.530 96 225 1.1E-17 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 SUPERFAMILY SSF46785 26 96 1.61E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38840 8316e89ac9e22d4dc97391d6706d9b26 229 Pfam PF00392 Bacterial regulatory proteins, gntR family 33 92 7.3E-14 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS38790 a7331d257fc131d31a652b4ca481aac4 369 TIGRFAM TIGR00157 TIGR00157: ribosome small subunit-dependent GTPase A 91 326 9.3E-47 T 17-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SHXM_RS38790 a7331d257fc131d31a652b4ca481aac4 369 Gene3D G3DSA:1.10.40.50 273 338 5.0E-22 T 17-03-2017 SHXM_RS38790 a7331d257fc131d31a652b4ca481aac4 369 Pfam PF03193 Protein of unknown function, DUF258 94 269 1.1E-44 T 17-03-2017 IPR010914 RsgA type GTPase domain GO:0003924|GO:0005525 SHXM_RS38790 a7331d257fc131d31a652b4ca481aac4 369 Gene3D G3DSA:3.40.50.300 112 266 2.3E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38790 a7331d257fc131d31a652b4ca481aac4 369 SUPERFAMILY SSF52540 112 331 1.66E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38790 a7331d257fc131d31a652b4ca481aac4 369 Hamap MF_01820 Putative ribosome biogenesis GTPase RsgA [rsgA]. 36 333 30.756 T 17-03-2017 IPR004881 Ribosome biogenesis GTPase RsgA, putative GO:0003924|GO:0005525 SHXM_RS13945 81d08235347f36657120ad3f19a41796 118 SUPERFAMILY SSF48498 6 116 2.33E-21 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS13945 81d08235347f36657120ad3f19a41796 118 Gene3D G3DSA:1.10.357.10 20 116 9.9E-17 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS13945 81d08235347f36657120ad3f19a41796 118 Pfam PF16925 Bacterial transcriptional repressor C-terminal 27 101 4.0E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS24210 5036b0f792552e4e8d4287d802ecddb0 1370 Pfam PF13641 Glycosyltransferase like family 2 47 290 3.3E-14 T 17-03-2017 SHXM_RS24210 5036b0f792552e4e8d4287d802ecddb0 1370 Gene3D G3DSA:3.90.550.10 151 291 3.6E-28 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24210 5036b0f792552e4e8d4287d802ecddb0 1370 Gene3D G3DSA:3.90.550.10 35 114 3.6E-28 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24210 5036b0f792552e4e8d4287d802ecddb0 1370 SUPERFAMILY SSF53448 150 291 1.04E-30 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24210 5036b0f792552e4e8d4287d802ecddb0 1370 SUPERFAMILY SSF53448 31 113 1.04E-30 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 SMART SM00829 10 355 2.7E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 SUPERFAMILY SSF51735 153 328 2.58E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 Gene3D G3DSA:3.90.180.10 2 185 2.2E-55 T 17-03-2017 IPR011032 GroES-like SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 149 2.0E-27 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 SUPERFAMILY SSF50129 2 196 7.15E-47 T 17-03-2017 IPR011032 GroES-like SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 Pfam PF00107 Zinc-binding dehydrogenase 192 313 2.7E-25 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 Gene3D G3DSA:3.40.50.720 186 301 4.8E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 SUPERFAMILY SSF50129 317 359 3.77E-5 T 17-03-2017 IPR011032 GroES-like SHXM_RS19735 0d91d97211a92eee2e6fd189172fe1d6 361 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 60 74 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 Hamap MF_01976 Pyrophosphate--fructose 6-phosphate 1-phosphotransferase [pfp]. 1 341 42.878 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 SUPERFAMILY SSF53784 1 333 3.79E-117 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 Gene3D G3DSA:3.40.50.450 1 213 1.0E-71 T 17-03-2017 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 TIGRFAM TIGR02483 PFK_mixed: phosphofructokinase 2 322 1.1E-144 T 17-03-2017 IPR012829 Phosphofructokinase, mixed-substrate PFK group III GO:0006096|GO:0047334 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 Pfam PF00365 Phosphofructokinase 2 297 3.7E-102 T 17-03-2017 IPR000023 Phosphofructokinase domain GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 262 284 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 5 24 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 176 193 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 212 224 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 120 137 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 138 156 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 158 174 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 93 109 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PRINTS PR00476 ATP-dependent phosphofructokinase family signature 31 44 5.6E-76 T 17-03-2017 IPR022953 ATP-dependent 6-phosphofructokinase GO:0003872|GO:0006002|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 ProSitePatterns PS00433 Phosphofructokinase signature. 266 284 - T 17-03-2017 IPR015912 Phosphofructokinase, conserved site GO:0003872|GO:0006096 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385|Reactome: R-HSA-70171 SHXM_RS08405 b76b7c2d431907e4171bcc394c85373d 341 PIRSF PIRSF000532 1 339 3.1E-115 T 17-03-2017 IPR012003 ATP-dependent 6-phosphofructokinase, prokaryotic-type GO:0005524|GO:0006002|GO:0006096|GO:0008443 KEGG: 00010+2.7.1.11|KEGG: 00030+2.7.1.11|KEGG: 00051+2.7.1.11|KEGG: 00052+2.7.1.11|KEGG: 00680+2.7.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1861|MetaCyc: PWY-5484|MetaCyc: PWY-7385 SHXM_RS43525 542e9e21256a3af39063253352df8991 292 PRINTS PR01438 Universal stress protein signature 267 289 5.7E-12 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43525 542e9e21256a3af39063253352df8991 292 PRINTS PR01438 Universal stress protein signature 249 261 5.7E-12 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43525 542e9e21256a3af39063253352df8991 292 PRINTS PR01438 Universal stress protein signature 2 20 5.7E-12 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43525 542e9e21256a3af39063253352df8991 292 SUPERFAMILY SSF52402 150 289 2.26E-19 T 17-03-2017 SHXM_RS43525 542e9e21256a3af39063253352df8991 292 Gene3D G3DSA:3.40.50.620 4 139 3.0E-27 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43525 542e9e21256a3af39063253352df8991 292 Gene3D G3DSA:3.40.50.620 149 289 4.8E-23 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43525 542e9e21256a3af39063253352df8991 292 Pfam PF00582 Universal stress protein family 151 289 2.3E-16 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43525 542e9e21256a3af39063253352df8991 292 Pfam PF00582 Universal stress protein family 5 139 4.0E-21 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43525 542e9e21256a3af39063253352df8991 292 SUPERFAMILY SSF52402 5 141 5.19E-24 T 17-03-2017 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 Gene3D G3DSA:3.50.50.60 184 376 3.0E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PIRSF PIRSF000332 8 331 2.0E-24 T 17-03-2017 IPR012143 Dimethylaniline monooxygenase, N-oxide-forming GO:0004499|GO:0050660|GO:0050661|GO:0055114 KEGG: 00982+1.14.13.8 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 SUPERFAMILY SSF51905 12 232 2.59E-41 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 173 191 9.3E-10 T 17-03-2017 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 115 133 9.3E-10 T 17-03-2017 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 12 31 9.3E-10 T 17-03-2017 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 169 193 2.9E-10 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 11 33 2.9E-10 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 130 138 2.9E-10 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 14 204 2.8E-26 T 17-03-2017 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 SUPERFAMILY SSF51905 170 208 5.35E-7 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 SUPERFAMILY SSF51905 265 377 5.35E-7 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31735 acfc6771c01852c21a04151edd390a18 384 Gene3D G3DSA:3.50.50.60 6 183 5.7E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 120 128 1.4E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 159 1.4E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 67 78 1.4E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 Pfam PF00106 short chain dehydrogenase 2 179 5.1E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 Gene3D G3DSA:3.40.50.720 2 241 1.8E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 114 130 1.8E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 67 78 1.8E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 1.8E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 178 1.8E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 140 159 1.8E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS01240 6bc737eccc41ecb4b0bbe48458225dbf 249 SUPERFAMILY SSF51735 1 239 2.47E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 Gene3D G3DSA:3.20.20.40 35 455 1.0E-116 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 Pfam PF01341 Glycosyl hydrolases family 6 59 404 3.7E-91 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PIRSF PIRSF001100 6 455 2.1E-96 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 140 155 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 214 227 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 317 330 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 358 378 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 58 77 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 108 121 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 254 264 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 PRINTS PR00733 Glycosyl hydrolase family 6 signature 381 395 1.3E-37 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 SUPERFAMILY SSF51989 40 455 1.96E-99 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS22760 c8279428346828a5a3b5393859d3a68e 455 ProSitePatterns PS00655 Glycosyl hydrolases family 6 signature 1. 113 129 - T 17-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 Gene3D G3DSA:3.40.50.2300 60 182 1.1E-37 T 17-03-2017 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 SUPERFAMILY SSF47413 11 66 4.73E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 Pfam PF00356 Bacterial regulatory proteins, lacI family 12 57 1.8E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 SMART SM00354 10 81 4.2E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 Gene3D G3DSA:3.40.50.2300 183 316 2.0E-37 T 17-03-2017 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 Pfam PF13377 Periplasmic binding protein-like domain 179 335 3.8E-25 T 17-03-2017 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 Gene3D G3DSA:1.10.260.40 11 59 2.3E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40995 9c81278c3aeb362a7227e063b1fafd84 340 SUPERFAMILY SSF53822 71 327 6.28E-59 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS26155 d608eee67cd21c4a7f991a15fe72ae7d 181 Pfam PF10722 Putative bacterial sensory transduction regulator 22 144 8.7E-20 T 17-03-2017 IPR019660 Putative sensory transduction regulator YbjN SHXM_RS26155 d608eee67cd21c4a7f991a15fe72ae7d 181 Gene3D G3DSA:3.30.1460.10 24 155 2.5E-16 T 17-03-2017 SHXM_RS26155 d608eee67cd21c4a7f991a15fe72ae7d 181 SUPERFAMILY SSF69635 23 147 7.69E-32 T 17-03-2017 SHXM_RS23550 52f12c0de36bc5a76ee373bd5a9a6eff 204 Gene3D G3DSA:1.10.10.10 26 98 3.0E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23550 52f12c0de36bc5a76ee373bd5a9a6eff 204 Pfam PF12840 Helix-turn-helix domain 29 82 7.8E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23550 52f12c0de36bc5a76ee373bd5a9a6eff 204 SMART SM00418 24 121 7.1E-10 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS23550 52f12c0de36bc5a76ee373bd5a9a6eff 204 SUPERFAMILY SSF46785 25 104 1.05E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31550 6e1ce1b34bcf6b184316c6ff387e3bed 222 Gene3D G3DSA:2.40.33.20 3 219 1.7E-72 T 17-03-2017 IPR015808 Molybdenum cofactor sulfurase, C-terminal-like SHXM_RS31550 6e1ce1b34bcf6b184316c6ff387e3bed 222 SUPERFAMILY SSF50800 3 219 1.62E-55 T 17-03-2017 IPR011037 Pyruvate kinase-like, insert domain SHXM_RS31550 6e1ce1b34bcf6b184316c6ff387e3bed 222 Pfam PF03473 MOSC domain 60 173 2.7E-24 T 17-03-2017 IPR005302 Molybdenum cofactor sulfurase, C-terminal GO:0003824|GO:0030151|GO:0030170 SHXM_RS50355 b21d3a0d7c5debcbe25707e3dda8008e 184 TIGRFAM TIGR03567 FMN_reduc_SsuE: FMN reductase 4 169 1.7E-65 T 17-03-2017 IPR020048 NADPH-dependent FMN reductase, SsuE GO:0008752|GO:0046306|GO:0055114 KEGG: 00740+1.5.1.38|MetaCyc: PWY-7723 SHXM_RS50355 b21d3a0d7c5debcbe25707e3dda8008e 184 Pfam PF03358 NADPH-dependent FMN reductase 4 144 2.4E-29 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS50355 b21d3a0d7c5debcbe25707e3dda8008e 184 Gene3D G3DSA:3.40.50.360 1 170 7.0E-33 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS50355 b21d3a0d7c5debcbe25707e3dda8008e 184 SUPERFAMILY SSF52218 4 169 1.13E-30 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 4.9E-15 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 SUPERFAMILY SSF46785 2 79 7.07E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 SUPERFAMILY SSF53850 88 291 1.77E-40 T 17-03-2017 SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 Gene3D G3DSA:3.40.190.10 168 263 8.1E-24 T 17-03-2017 SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 Gene3D G3DSA:3.40.190.10 87 167 3.7E-21 T 17-03-2017 SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 Gene3D G3DSA:3.40.190.10 267 295 3.7E-21 T 17-03-2017 SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 Gene3D G3DSA:1.10.10.10 1 82 2.0E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10890 ef495d59d0f1ee9096232286a1668f6a 315 Pfam PF03466 LysR substrate binding domain 101 292 1.7E-30 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS44835 35e9c3689996113c94565add10e99235 337 SUPERFAMILY SSF46785 172 233 1.22E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Gene3D G3DSA:1.10.10.10 10 57 8.9E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 SUPERFAMILY SSF54909 245 320 2.95E-9 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44835 35e9c3689996113c94565add10e99235 337 SMART SM00344 188 288 5.7E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS44835 35e9c3689996113c94565add10e99235 337 SMART SM00344 11 116 4.7E-4 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS44835 35e9c3689996113c94565add10e99235 337 SUPERFAMILY SSF46785 11 58 4.29E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Pfam PF01037 Lrp/AsnC ligand binding domain 76 146 3.2E-7 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Pfam PF01037 Lrp/AsnC ligand binding domain 250 318 1.5E-7 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Pfam PF13404 AsnC-type helix-turn-helix domain 11 51 6.0E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS44835 35e9c3689996113c94565add10e99235 337 SUPERFAMILY SSF54909 75 146 1.11E-9 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Gene3D G3DSA:1.10.10.10 180 257 1.9E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Pfam PF09339 IclR helix-turn-helix domain 193 230 2.3E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Gene3D G3DSA:3.30.70.920 258 318 2.0E-12 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS44835 35e9c3689996113c94565add10e99235 337 Gene3D G3DSA:3.30.70.920 75 146 2.1E-11 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 Gene3D G3DSA:3.40.190.10 96 176 2.5E-19 T 17-03-2017 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 SUPERFAMILY SSF53850 92 299 9.15E-36 T 17-03-2017 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 Pfam PF03466 LysR substrate binding domain 91 292 3.5E-39 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 22 33 3.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 33 43 3.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 43 54 3.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 66 1.6E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 SUPERFAMILY SSF46785 6 89 8.3E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 Gene3D G3DSA:3.40.190.10 177 270 8.8E-22 T 17-03-2017 SHXM_RS48710 003d3eac3122f7b454044f1ccdc146fa 309 Gene3D G3DSA:1.10.10.10 6 89 4.3E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30420 94bbc4b42b8dce8a8f5061558aea9fba 32 Pfam PF08213 Mitochondrial domain of unknown function (DUF1713) 2 30 3.0E-9 T 17-03-2017 IPR013177 Domain of unknown function DUF1713 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS30420 94bbc4b42b8dce8a8f5061558aea9fba 32 SMART SM01155 1 32 3.8E-5 T 17-03-2017 IPR013177 Domain of unknown function DUF1713 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 Gene3D G3DSA:1.20.140.10 232 395 3.2E-52 T 17-03-2017 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 241 389 1.0E-40 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 Gene3D G3DSA:2.40.110.10 129 231 5.8E-28 T 17-03-2017 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 130 212 2.3E-17 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 Gene3D G3DSA:1.10.540.10 5 128 1.4E-22 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 SUPERFAMILY SSF56645 4 253 1.31E-56 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 SUPERFAMILY SSF47203 239 392 1.58E-49 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10725 f591f047e782dec16f12d96b5196f860 400 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 15 126 6.7E-15 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS11130 f39579df467834c2f844fb18f60808d0 529 Gene3D G3DSA:3.40.50.2300 141 313 1.2E-11 T 17-03-2017 SHXM_RS11130 f39579df467834c2f844fb18f60808d0 529 Pfam PF13458 Periplasmic binding protein 124 431 2.5E-10 T 17-03-2017 IPR028081 Leucine-binding protein domain SHXM_RS11130 f39579df467834c2f844fb18f60808d0 529 SUPERFAMILY SSF53822 100 438 1.0E-18 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS10700 703fd89616f0b1d5f32a8ee6135ab87f 390 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 16 128 3.0E-16 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS10700 703fd89616f0b1d5f32a8ee6135ab87f 390 Gene3D G3DSA:1.20.140.10 239 380 1.7E-33 T 17-03-2017 SHXM_RS10700 703fd89616f0b1d5f32a8ee6135ab87f 390 SUPERFAMILY SSF47203 241 380 3.7E-34 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10700 703fd89616f0b1d5f32a8ee6135ab87f 390 SUPERFAMILY SSF56645 15 191 4.45E-27 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10700 703fd89616f0b1d5f32a8ee6135ab87f 390 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 239 379 4.2E-25 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS10700 703fd89616f0b1d5f32a8ee6135ab87f 390 Gene3D G3DSA:1.10.540.10 16 129 3.1E-17 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 342 351 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 Pfam PF00067 Cytochrome P450 261 369 1.0E-17 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 Gene3D G3DSA:1.10.630.10 21 400 1.2E-104 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00385 P450 superfamily signature 349 360 6.7E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00385 P450 superfamily signature 340 349 6.7E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00385 P450 superfamily signature 238 255 6.7E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 SUPERFAMILY SSF48264 22 400 2.88E-80 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 319 334 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 153 168 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 340 349 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 291 318 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 349 360 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 136 152 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 273 284 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS33065 d298c36f6533c804e077a73fb8656b19 400 PRINTS PR00359 B-class P450 signature 191 213 8.2E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 37 59 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SUPERFAMILY SSF50998 458 674 2.43E-17 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SUPERFAMILY SSF56112 28 304 9.31E-63 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SMART SM00564 654 689 61.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SMART SM00564 697 729 0.067 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SMART SM00564 522 553 8.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SMART SM00564 481 514 15.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 149 161 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 Gene3D G3DSA:3.30.200.20 24 104 6.4E-14 T 17-03-2017 SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 Pfam PF13570 PQQ-like domain 684 720 1.0E-5 T 17-03-2017 IPR025666 Pyrrolo-quinoline quinone-like domain SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SMART SM00220 31 283 1.4E-42 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 Pfam PF00069 Protein kinase domain 31 277 2.8E-36 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 Gene3D G3DSA:2.140.10.10 414 766 8.0E-29 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 SUPERFAMILY SSF50998 652 768 6.44E-16 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 Pfam PF13360 PQQ-like domain 428 634 6.7E-13 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS30350 77e4b70a254cf73a906652643d079aa6 773 Gene3D G3DSA:1.10.510.10 116 306 7.2E-43 T 17-03-2017 SHXM_RS48090 db5085c8ae202cc287431508f405da0d 553 PIRSF PIRSF006060 5 541 1.1E-69 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS48090 db5085c8ae202cc287431508f405da0d 553 Pfam PF13520 Amino acid permease 22 421 3.6E-40 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS34875 0308c0d31bd5be619b3932adf3946c04 197 Gene3D G3DSA:3.90.1570.10 25 179 2.5E-11 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS34875 0308c0d31bd5be619b3932adf3946c04 197 Pfam PF05685 Putative restriction endonuclease 24 189 5.6E-25 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS34875 0308c0d31bd5be619b3932adf3946c04 197 SUPERFAMILY SSF52980 33 191 1.29E-10 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS37400 3eaaf6a6f856ef34a6afb0bbe0dc3477 202 SUPERFAMILY SSF54909 13 84 3.84E-6 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS37400 3eaaf6a6f856ef34a6afb0bbe0dc3477 202 SUPERFAMILY SSF54909 105 167 2.01E-5 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS37400 3eaaf6a6f856ef34a6afb0bbe0dc3477 202 Pfam PF16291 Domain of unknown function (DUF4937 2 86 9.1E-30 T 17-03-2017 IPR032555 Domain of unknown function DUF4937 SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 Gene3D G3DSA:1.10.10.10 344 414 3.7E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 Pfam PF00196 Bacterial regulatory proteins, luxR family 359 412 1.0E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 360 374 1.4E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 374 390 1.4E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 390 402 1.4E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 SMART SM00421 357 414 1.8E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39565 82f6f09ebb1e5a86ee8d1a4956be17ac 449 SUPERFAMILY SSF46894 350 415 4.76E-16 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS00965 a0f28c6f163ce45bd8840868f1bd739a 196 SMART SM00530 15 70 1.4E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS00965 a0f28c6f163ce45bd8840868f1bd739a 196 SUPERFAMILY SSF51182 80 193 3.67E-14 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS00965 a0f28c6f163ce45bd8840868f1bd739a 196 Gene3D G3DSA:1.10.260.40 11 80 1.6E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00965 a0f28c6f163ce45bd8840868f1bd739a 196 Gene3D G3DSA:2.60.120.10 89 193 2.4E-12 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS00965 a0f28c6f163ce45bd8840868f1bd739a 196 SUPERFAMILY SSF47413 11 75 4.56E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00965 a0f28c6f163ce45bd8840868f1bd739a 196 Pfam PF01381 Helix-turn-helix 17 68 2.2E-13 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS21560 8c9aa36740cf11caa48c1eca92756413 415 Gene3D G3DSA:3.30.2010.10 80 165 5.7E-19 T 17-03-2017 SHXM_RS21560 8c9aa36740cf11caa48c1eca92756413 415 Pfam PF01435 Peptidase family M48 85 279 5.1E-24 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS32710 0705850f82a01a4cbc73168348e84a6f 556 Pfam PF00474 Sodium:solute symporter family 44 453 1.4E-47 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS32710 0705850f82a01a4cbc73168348e84a6f 556 TIGRFAM TIGR00813 sss: transporter, solute:sodium symporter (SSS) family 44 453 6.0E-69 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 SUPERFAMILY SSF102114 21 366 7.19E-44 T 17-03-2017 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 Pfam PF04055 Radical SAM superfamily 66 236 6.9E-11 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 Gene3D G3DSA:3.20.20.70 22 365 1.6E-55 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 PIRSF PIRSF004762 4 385 1.5E-100 T 17-03-2017 IPR005244 FO synthase, subunit 2-like GO:0016765|GO:0051188|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 Hamap MF_00993 Aminodeoxyfutalosine synthase [mqnE]. 12 376 48.473 T 17-03-2017 IPR022432 Aminodeoxyfutalosine synthase GO:0009234 KEGG: 00130+2.5.1.120|MetaCyc: PWY-7371|MetaCyc: PWY-7374 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 57 373 2.9E-92 T 17-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 SMART SM00729 61 275 0.0053 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS30655 392f2553b5ee66d71accaa83f99479d6 392 TIGRFAM TIGR03700 mena_SCO4494: putative menaquinone biosynthesis radical SAM enzyme, SCO4494 family 15 373 6.0E-164 T 17-03-2017 IPR022432 Aminodeoxyfutalosine synthase GO:0009234 KEGG: 00130+2.5.1.120|MetaCyc: PWY-7371|MetaCyc: PWY-7374 SHXM_RS04335 eb82dbddf0cfa3c756e1b5c5edb41c99 115 SMART SM00823 Phosphopantetheine attachment site 48 115 2.2E-22 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04335 eb82dbddf0cfa3c756e1b5c5edb41c99 115 SMART SM01294 49 115 8.3E-4 T 17-03-2017 SHXM_RS04335 eb82dbddf0cfa3c756e1b5c5edb41c99 115 Pfam PF00550 Phosphopantetheine attachment site 50 115 3.3E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04335 eb82dbddf0cfa3c756e1b5c5edb41c99 115 SUPERFAMILY SSF47336 41 115 1.83E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS04335 eb82dbddf0cfa3c756e1b5c5edb41c99 115 Gene3D G3DSA:1.10.1200.10 45 115 2.1E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 550 846 1.7E-93 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.40.366.10 545 666 1.2E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.40.366.10 736 850 1.2E-68 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 174 190 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF47336 2034 2117 3.53E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 1768 1948 2.6E-45 T 17-03-2017 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 14 261 4.4E-84 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.40.47.10 274 436 7.4E-60 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SMART SM00825 Beta-ketoacyl synthase 15 436 7.6E-188 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF52151 738 830 2.62E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF52151 547 672 2.62E-61 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SMART SM00826 910 1075 5.1E-29 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF00107 Zinc-binding dehydrogenase 1574 1687 6.3E-23 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:1.10.1200.10 2038 2112 3.7E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF08659 KR domain 1768 1946 1.5E-59 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF55048 670 736 1.15E-8 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SMART SM00823 Phosphopantetheine attachment site 2041 2112 6.2E-18 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 269 383 3.0E-39 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 ProSitePatterns PS00012 Phosphopantetheine attachment site. 2067 2082 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.40.50.720 1569 1663 1.6E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.40.47.10 15 273 4.6E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF51735 1539 1711 1.86E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 1449 1510 3.3E-6 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF14765 Polyketide synthase dehydratase 914 1187 1.6E-51 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF51735 1197 1402 3.71E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF51735 1765 2005 1.78E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.90.180.10 1436 1568 3.8E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF50129 1427 1568 8.18E-34 T 17-03-2017 IPR011032 GroES-like SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SMART SM00829 1432 1745 2.6E-162 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF00550 Phosphopantetheine attachment site 2043 2106 2.3E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Gene3D G3DSA:3.40.50.720 1766 1970 1.0E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 390 493 1.4E-11 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 Pfam PF00698 Acyl transferase domain 548 864 2.4E-91 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS06635 75dd83ef7ac7083b0a16010c27e54381 2128 SUPERFAMILY SSF53901 10 382 7.07E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43480 2858974750b454460491976685398237 373 PIRSF PIRSF005622 1 363 3.6E-153 T 17-03-2017 IPR002780 Hydrogenase formation HypD protein GO:0046872 SHXM_RS43480 2858974750b454460491976685398237 373 TIGRFAM TIGR00075 hypD: hydrogenase expression/formation protein HypD 3 361 7.1E-145 T 17-03-2017 IPR002780 Hydrogenase formation HypD protein GO:0046872 SHXM_RS43480 2858974750b454460491976685398237 373 Pfam PF01924 Hydrogenase formation hypA family 12 359 1.2E-149 T 17-03-2017 IPR002780 Hydrogenase formation HypD protein GO:0046872 SHXM_RS12485 18d15385a21afaa7eabe13a163a08b82 425 Gene3D G3DSA:3.30.565.10 329 413 7.3E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS12485 18d15385a21afaa7eabe13a163a08b82 425 SMART SM00387 320 413 5.1E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS12485 18d15385a21afaa7eabe13a163a08b82 425 Pfam PF07730 Histidine kinase 215 281 2.7E-13 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS12485 18d15385a21afaa7eabe13a163a08b82 425 PIRSF PIRSF037434 24 418 1.2E-75 T 17-03-2017 IPR017205 Signal transduction histidine kinase, ChrS SHXM_RS12485 18d15385a21afaa7eabe13a163a08b82 425 SUPERFAMILY SSF55874 287 410 2.1E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34750 9d2754114d3a01b3cb209e195b746f33 258 SUPERFAMILY SSF53335 10 167 3.77E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS34750 9d2754114d3a01b3cb209e195b746f33 258 Gene3D G3DSA:3.40.50.150 9 182 1.8E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS34750 9d2754114d3a01b3cb209e195b746f33 258 Pfam PF13649 Methyltransferase domain 49 148 6.0E-16 T 17-03-2017 SHXM_RS49775 958384c482d63337c26ec9aa9eca7155 248 Pfam PF16715 Cyclodipeptide synthase 34 200 9.4E-19 T 17-03-2017 IPR030903 Cyclodileucine synthase GO:0016755 SHXM_RS49775 958384c482d63337c26ec9aa9eca7155 248 TIGRFAM TIGR04539 tRNA_cyclodipep: tRNA-dependent cyclodipeptide synthase 29 242 1.4E-39 T 17-03-2017 IPR030903 Cyclodileucine synthase GO:0016755 SHXM_RS18855 951946e8b0286de1978b2a9229f499fd 93 Gene3D G3DSA:3.30.70.920 5 78 2.0E-25 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS18855 951946e8b0286de1978b2a9229f499fd 93 SUPERFAMILY SSF54909 3 78 7.64E-19 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS18855 951946e8b0286de1978b2a9229f499fd 93 Pfam PF01037 Lrp/AsnC ligand binding domain 6 77 8.0E-18 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS01915 ca2d2c67200ff282e081074bfccfede0 410 SUPERFAMILY SSF51679 15 403 1.47E-76 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01915 ca2d2c67200ff282e081074bfccfede0 410 Pfam PF00296 Luciferase-like monooxygenase 31 320 2.6E-31 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01915 ca2d2c67200ff282e081074bfccfede0 410 Gene3D G3DSA:3.20.20.30 12 404 8.2E-112 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS27320 92f86c6b0f6f1a3ce216871aaf21ef38 166 Gene3D G3DSA:3.40.140.10 24 165 1.5E-57 T 17-03-2017 SHXM_RS27320 92f86c6b0f6f1a3ce216871aaf21ef38 166 SUPERFAMILY SSF53927 20 164 8.53E-53 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS27320 92f86c6b0f6f1a3ce216871aaf21ef38 166 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 71 108 - T 17-03-2017 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SHXM_RS27320 92f86c6b0f6f1a3ce216871aaf21ef38 166 Hamap MF_00972 tRNA-specific adenosine deaminase [tadA]. 25 164 45.017 T 17-03-2017 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 Reactome: R-HSA-6782315 SHXM_RS27320 92f86c6b0f6f1a3ce216871aaf21ef38 166 Pfam PF14437 MafB19-like deaminase 22 165 1.8E-29 T 17-03-2017 IPR028883 tRNA-specific adenosine deaminase GO:0002100|GO:0008251 Reactome: R-HSA-6782315 SHXM_RS28195 fafc1b204af047f27d885ba43a390f8b 383 SUPERFAMILY SSF52172 244 376 3.7E-36 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS28195 fafc1b204af047f27d885ba43a390f8b 383 Gene3D G3DSA:3.40.50.2300 244 365 1.4E-36 T 17-03-2017 SHXM_RS28195 fafc1b204af047f27d885ba43a390f8b 383 SMART SM00448 246 361 1.8E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28195 fafc1b204af047f27d885ba43a390f8b 383 Pfam PF00072 Response regulator receiver domain 248 361 8.8E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27005 0d08dd3f87af286857efb2f6fd263407 276 Gene3D G3DSA:3.60.15.10 21 234 4.5E-47 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS27005 0d08dd3f87af286857efb2f6fd263407 276 SMART SM00849 39 204 1.4E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS27005 0d08dd3f87af286857efb2f6fd263407 276 Pfam PF00753 Metallo-beta-lactamase superfamily 36 204 1.3E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS27005 0d08dd3f87af286857efb2f6fd263407 276 SUPERFAMILY SSF56281 21 275 7.84E-50 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS38220 e7ac8d3b43676ea905d8974ba30e72a2 348 SUPERFAMILY SSF89372 8 303 3.92E-17 T 17-03-2017 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SUPERFAMILY SSF50978 892 970 2.2E-41 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SUPERFAMILY SSF50978 523 777 2.2E-41 T 17-03-2017 IPR017986 WD40-repeat-containing domain GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Pfam PF13676 TIR domain 20 117 2.3E-10 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Pfam PF00400 WD domain, G-beta repeat 342 366 0.028 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SUPERFAMILY SSF82171 310 621 3.37E-35 T 17-03-2017 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Pfam PF07676 WD40-like Beta Propeller Repeat 399 434 0.0071 T 17-03-2017 IPR011659 WD40-like Beta Propeller SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00255 16 161 9.7E-13 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 ProSitePatterns PS00678 Trp-Asp (WD) repeats signature. 422 436 - T 17-03-2017 IPR019775 WD40 repeat, conserved site SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Gene3D G3DSA:3.40.50.10140 16 115 2.8E-10 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 586 624 28.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 885 924 7.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 629 668 1.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 674 719 4.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 442 477 420.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 338 389 0.54 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 295 332 330.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 501 535 450.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 930 969 2.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 541 579 0.12 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 395 435 3.2 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SMART SM00320 725 767 45.0 T 17-03-2017 IPR001680 WD40 repeat GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Gene3D G3DSA:2.130.10.10 310 608 2.2E-37 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Gene3D G3DSA:2.130.10.10 852 970 2.5E-35 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 Gene3D G3DSA:2.130.10.10 609 781 2.5E-35 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS00410 8f8fb190b2e35147f6d227dfa99e59a5 1013 SUPERFAMILY SSF52200 14 115 3.53E-13 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS45155 f1d212dde61f8af05b851e8e83b63bb7 300 SUPERFAMILY SSF54637 6 114 3.83E-42 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45155 f1d212dde61f8af05b851e8e83b63bb7 300 SUPERFAMILY SSF54637 116 285 5.31E-52 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45155 f1d212dde61f8af05b851e8e83b63bb7 300 Pfam PF13622 Thioesterase-like superfamily 33 282 5.4E-63 T 17-03-2017 SHXM_RS45155 f1d212dde61f8af05b851e8e83b63bb7 300 Gene3D G3DSA:3.10.129.10 4 115 2.3E-48 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45155 f1d212dde61f8af05b851e8e83b63bb7 300 Gene3D G3DSA:3.10.129.10 124 285 8.5E-53 T 17-03-2017 IPR029069 HotDog domain SHXM_RS00600 f602fd2ac1821934b3cc42e02574952c 138 Pfam PF07366 SnoaL-like polyketide cyclase 10 132 1.2E-27 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS00600 f602fd2ac1821934b3cc42e02574952c 138 Gene3D G3DSA:3.10.450.50 6 133 1.4E-32 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS00600 f602fd2ac1821934b3cc42e02574952c 138 SUPERFAMILY SSF54427 6 132 4.39E-31 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 Gene3D G3DSA:3.50.50.60 3 170 1.7E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 Gene3D G3DSA:3.50.50.60 274 354 1.7E-52 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 SUPERFAMILY SSF51905 273 362 3.6E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 SUPERFAMILY SSF51905 3 165 3.6E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 Pfam PF01494 FAD binding domain 3 350 5.8E-68 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 7.8E-41 T 17-03-2017 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 301 317 7.8E-41 T 17-03-2017 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 286 301 7.8E-41 T 17-03-2017 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 337 353 7.8E-41 T 17-03-2017 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 144 159 7.8E-41 T 17-03-2017 SHXM_RS35570 63475ba4cda80d8efdfb7eeded5aaf48 484 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 319 337 7.8E-41 T 17-03-2017 SHXM_RS50440 ac87bf74b393f206f9f24fda2db31fa8 179 Gene3D G3DSA:1.10.10.60 18 88 6.4E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50440 ac87bf74b393f206f9f24fda2db31fa8 179 Pfam PF13551 Winged helix-turn helix 21 80 5.4E-10 T 17-03-2017 SHXM_RS50440 ac87bf74b393f206f9f24fda2db31fa8 179 Pfam PF13592 Winged helix-turn helix 97 155 2.1E-22 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS50440 ac87bf74b393f206f9f24fda2db31fa8 179 SUPERFAMILY SSF46689 2 130 2.02E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS02025 bd4fb1940da40d7687e83462cdd7f8ba 210 Pfam PF00296 Luciferase-like monooxygenase 10 159 6.1E-14 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS02025 bd4fb1940da40d7687e83462cdd7f8ba 210 SUPERFAMILY SSF51679 9 171 1.47E-18 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS02025 bd4fb1940da40d7687e83462cdd7f8ba 210 Gene3D G3DSA:3.20.20.30 8 171 3.1E-19 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS23490 573f49b90c18e5b880866279320ec3ec 143 Pfam PF13581 Histidine kinase-like ATPase domain 23 121 2.0E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS23490 573f49b90c18e5b880866279320ec3ec 143 SUPERFAMILY SSF55874 45 114 4.52E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45090 bd0447db75807226b781def4c2fe0405 367 SUPERFAMILY SSF51126 49 362 6.54E-63 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS45090 bd0447db75807226b781def4c2fe0405 367 Pfam PF01095 Pectinesterase 55 339 9.1E-43 T 17-03-2017 IPR000070 Pectinesterase, catalytic GO:0005618|GO:0030599|GO:0042545 KEGG: 00040+3.1.1.11|KEGG: 00500+3.1.1.11|MetaCyc: PWY-1081|MetaCyc: PWY-7246|MetaCyc: PWY-7248 SHXM_RS45090 bd0447db75807226b781def4c2fe0405 367 Gene3D G3DSA:2.160.20.10 52 365 1.6E-88 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 Gene3D G3DSA:3.30.70.360 217 317 2.5E-27 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 Pfam PF01546 Peptidase family M20/M25/M40 67 390 2.2E-24 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 SUPERFAMILY SSF55031 206 315 4.54E-17 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 SUPERFAMILY SSF53187 8 213 9.43E-69 T 17-03-2017 SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 SUPERFAMILY SSF53187 317 393 9.43E-69 T 17-03-2017 SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 Gene3D G3DSA:3.40.630.10 2 216 4.1E-94 T 17-03-2017 SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 Gene3D G3DSA:3.40.630.10 335 393 4.1E-94 T 17-03-2017 SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 PIRSF PIRSF001235 1 395 5.0E-120 T 17-03-2017 IPR010158 Amidase, carbamoylase-type GO:0008152|GO:0016813 SHXM_RS24385 2e88d49813f1acdb7b49b4c8f5760182 395 TIGRFAM TIGR01879 hydantase: amidase, hydantoinase/carbamoylase family 8 389 4.3E-81 T 17-03-2017 IPR010158 Amidase, carbamoylase-type GO:0008152|GO:0016813 SHXM_RS43660 e4a682b4802fdeb851dd1ff8fe5496f6 474 SUPERFAMILY SSF48371 237 435 7.89E-6 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS43660 e4a682b4802fdeb851dd1ff8fe5496f6 474 Gene3D G3DSA:1.25.10.10 235 324 6.2E-4 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 Gene3D G3DSA:3.40.190.10 179 266 2.9E-27 T 17-03-2017 SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 62 2.7E-18 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 Gene3D G3DSA:3.40.190.10 90 178 1.1E-16 T 17-03-2017 SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 SUPERFAMILY SSF46785 5 109 9.52E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 Pfam PF03466 LysR substrate binding domain 87 291 3.7E-42 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 SUPERFAMILY SSF53850 88 300 8.36E-39 T 17-03-2017 SHXM_RS41050 dd3d5798e47d67a5e76c5deee58c8f9f 304 Gene3D G3DSA:1.10.10.10 5 85 1.3E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 Gene3D G3DSA:3.30.565.10 580 686 3.1E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 580 687 3.1E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 Gene3D G3DSA:3.30.420.150 282 406 3.7E-4 T 17-03-2017 SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 Pfam PF00672 HAMP domain 377 460 7.0E-12 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 SUPERFAMILY SSF55874 573 687 5.5E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 Pfam PF08376 Nitrate and nitrite sensing 97 356 6.9E-43 T 17-03-2017 IPR013587 Nitrate/nitrite sensing protein SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 SMART SM00387 577 689 7.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36275 1857d9f7471c13e0bfb6a00793e8320e 1010 SMART SM00304 395 465 1.7E-4 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 SMART SM00422 1 69 7.2E-19 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 Pfam PF13411 MerR HTH family regulatory protein 1 63 2.8E-20 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 SUPERFAMILY SSF46955 1 116 5.13E-26 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 Gene3D G3DSA:1.10.1660.10 1 116 2.3E-30 T 17-03-2017 SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 5.7E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 5.7E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS34835 52bbedc3d737c07e75f78dc56bc32c4c 126 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 5.7E-10 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS10750 11867b523f8513e6756bd11d5e013ceb 488 SUPERFAMILY SSF51735 240 382 5.14E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10750 11867b523f8513e6756bd11d5e013ceb 488 Gene3D G3DSA:3.40.50.720 242 380 1.0E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38150 0576d416862a5d07bf9f62fae4f86a76 281 SUPERFAMILY SSF51735 2 276 4.3E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38150 0576d416862a5d07bf9f62fae4f86a76 281 Pfam PF13460 NAD(P)H-binding 6 179 1.0E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38150 0576d416862a5d07bf9f62fae4f86a76 281 Gene3D G3DSA:3.40.50.720 2 215 1.0E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25815 9e34ce05188c49ae3dc91b222ca97a69 222 SUPERFAMILY SSF52317 4 213 9.61E-14 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS25815 9e34ce05188c49ae3dc91b222ca97a69 222 Gene3D G3DSA:3.40.50.880 1 220 2.8E-29 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS25815 9e34ce05188c49ae3dc91b222ca97a69 222 Pfam PF03575 Peptidase family S51 3 213 5.8E-51 T 17-03-2017 IPR005320 Peptidase S51 GO:0006508|GO:0008236 SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 Gene3D G3DSA:1.10.10.10 8 72 6.3E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 SUPERFAMILY SSF64288 59 248 1.57E-21 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 SUPERFAMILY SSF46785 4 79 5.1E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 Pfam PF07702 UTRA domain 111 242 3.2E-10 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 Pfam PF00392 Bacterial regulatory proteins, gntR family 9 71 5.4E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 SMART SM00866 94 242 1.8E-5 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 SMART SM00345 12 71 7.7E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS33785 7a4e99b64e0e42c43371e8cf3f31978b 250 Gene3D G3DSA:3.40.1410.10 73 245 5.9E-49 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS21605 80f603187950528cd057c235be01ebc0 106 Pfam PF00829 Ribosomal prokaryotic L21 protein 2 101 8.3E-31 T 17-03-2017 IPR028909 Ribosomal protein L21-like GO:0005840 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21605 80f603187950528cd057c235be01ebc0 106 ProSitePatterns PS01169 Ribosomal protein L21 signature. 72 94 - T 17-03-2017 IPR018258 Ribosomal protein L21, conserved site GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS21605 80f603187950528cd057c235be01ebc0 106 Hamap MF_01363 50S ribosomal protein L21 [rplU]. 1 103 21.875 T 17-03-2017 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21605 80f603187950528cd057c235be01ebc0 106 TIGRFAM TIGR00061 L21: ribosomal protein bL21 2 101 1.2E-23 T 17-03-2017 IPR001787 Ribosomal protein L21 GO:0003723|GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS21605 80f603187950528cd057c235be01ebc0 106 SUPERFAMILY SSF141091 1 101 1.23E-29 T 17-03-2017 IPR028909 Ribosomal protein L21-like GO:0005840 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS49750 15038872939df4e7e7e6f57ca2b6c64b 253 Pfam PF01144 Coenzyme A transferase 6 233 1.2E-72 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS49750 15038872939df4e7e7e6f57ca2b6c64b 253 TIGRFAM TIGR02429 pcaI_scoA_fam: 3-oxoacid CoA-transferase, A subunit 1 234 1.0E-68 T 17-03-2017 IPR012792 3-oxoacid CoA-transferase, subunit A GO:0008410 SHXM_RS49750 15038872939df4e7e7e6f57ca2b6c64b 253 SUPERFAMILY SSF100950 1 247 4.54E-88 T 17-03-2017 SHXM_RS49750 15038872939df4e7e7e6f57ca2b6c64b 253 SMART SM00882 5 234 7.2E-85 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS49750 15038872939df4e7e7e6f57ca2b6c64b 253 Gene3D G3DSA:3.40.1080.10 3 233 1.2E-102 T 17-03-2017 SHXM_RS39790 b4603326ac9ab2c51a8c655e75553dfa 296 Gene3D G3DSA:3.20.20.30 1 282 5.3E-56 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS39790 b4603326ac9ab2c51a8c655e75553dfa 296 Pfam PF00296 Luciferase-like monooxygenase 20 269 9.3E-43 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS39790 b4603326ac9ab2c51a8c655e75553dfa 296 SUPERFAMILY SSF51679 1 290 1.07E-54 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS39790 b4603326ac9ab2c51a8c655e75553dfa 296 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 23 271 7.0E-55 T 17-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted SHXM_RS28680 312dfad973e8efa8ad897f4b9e0f9bbb 366 Gene3D G3DSA:3.40.50.980 94 265 1.1E-5 T 17-03-2017 SHXM_RS28680 312dfad973e8efa8ad897f4b9e0f9bbb 366 Pfam PF00501 AMP-binding enzyme 96 315 1.5E-7 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS28680 312dfad973e8efa8ad897f4b9e0f9bbb 366 SUPERFAMILY SSF56801 76 317 7.06E-20 T 17-03-2017 SHXM_RS04135 ad5ec355d41ef99606b4957486a2d55a 485 Pfam PF00295 Glycosyl hydrolases family 28 84 375 1.6E-22 T 17-03-2017 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SHXM_RS04135 ad5ec355d41ef99606b4957486a2d55a 485 SUPERFAMILY SSF51126 13 370 8.64E-56 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS04135 ad5ec355d41ef99606b4957486a2d55a 485 Gene3D G3DSA:2.160.20.10 7 481 9.1E-77 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 ProDom PD006086 LIGASE LIPOATE-PROTEIN B TRANSFERASE ACYLTRANSFERASE LIPOYLTRANSFERASE LIPOYL-ACYL-CARRIER 2.3.1.- PROTEIN-PROTEIN- N-LIPOYLTRANSFERASE 88 140 6.0E-22 T 17-03-2017 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 Hamap MF_00013 Octanoyltransferase [lipB]. 14 264 32.551 T 17-03-2017 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 ProSitePatterns PS01313 Lipoate-protein ligase B signature. 84 99 - T 17-03-2017 IPR020605 Octanoyltransferase, conserved site GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 SUPERFAMILY SSF55681 25 143 5.8E-62 T 17-03-2017 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 SUPERFAMILY SSF55681 189 263 5.8E-62 T 17-03-2017 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 PIRSF PIRSF016262 14 267 4.2E-58 T 17-03-2017 IPR000544 Octanoyltransferase GO:0005737|GO:0009107|GO:0016415 KEGG: 00785+2.3.1.181|MetaCyc: PWY-6987|MetaCyc: PWY-7382|Reactome: R-HSA-389661 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 Gene3D G3DSA:3.90.1550.10 25 147 7.2E-77 T 17-03-2017 SHXM_RS19080 77a990bbf5025ab9236d4ca3c78f0ec1 271 Gene3D G3DSA:3.90.1550.10 190 261 7.2E-77 T 17-03-2017 SHXM_RS12880 9ff7b11aa6a607ce6ca71d8ae92468e4 180 Gene3D G3DSA:3.90.1570.10 20 159 4.4E-10 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS12880 9ff7b11aa6a607ce6ca71d8ae92468e4 180 Pfam PF05685 Putative restriction endonuclease 20 161 5.1E-15 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS12880 9ff7b11aa6a607ce6ca71d8ae92468e4 180 SUPERFAMILY SSF52980 21 159 9.65E-12 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 184 4.5E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 4.5E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 18 35 4.5E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 139 155 4.5E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 202 4.5E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 92 103 1.2E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 145 153 1.2E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 165 184 1.2E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 Pfam PF00106 short chain dehydrogenase 20 203 4.8E-48 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 152 180 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 SUPERFAMILY SSF51735 22 240 6.02E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02305 6c3f62df23b473cf6e61d6ba631f5ae9 255 Gene3D G3DSA:3.40.50.720 22 240 1.4E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS29750 3bf7936d65e1e7386410a38ad4ac219a 538 SUPERFAMILY SSF52540 213 515 5.45E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29750 3bf7936d65e1e7386410a38ad4ac219a 538 Pfam PF08378 Nuclease-related domain 14 114 1.3E-10 T 17-03-2017 IPR011528 Nuclease-related domain, NERD SHXM_RS29750 3bf7936d65e1e7386410a38ad4ac219a 538 Gene3D G3DSA:3.40.50.300 212 308 5.8E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29750 3bf7936d65e1e7386410a38ad4ac219a 538 Gene3D G3DSA:3.40.50.300 364 524 4.1E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29750 3bf7936d65e1e7386410a38ad4ac219a 538 Gene3D G3DSA:3.40.1350.10 40 70 9.4E-4 T 17-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 SHXM_RS13015 96359e33f47707216cabed72877b356a 143 SUPERFAMILY SSF54427 2 116 4.39E-18 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS13015 96359e33f47707216cabed72877b356a 143 Pfam PF12680 SnoaL-like domain 5 109 8.6E-10 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS13015 96359e33f47707216cabed72877b356a 143 Gene3D G3DSA:3.10.450.50 3 119 2.5E-16 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 SUPERFAMILY SSF52402 4 138 6.7E-27 T 17-03-2017 SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 SUPERFAMILY SSF52402 160 292 1.67E-16 T 17-03-2017 SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 Pfam PF00582 Universal stress protein family 4 136 1.3E-23 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 Pfam PF00582 Universal stress protein family 160 292 3.0E-13 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 Gene3D G3DSA:3.40.50.620 1 136 2.5E-30 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 Gene3D G3DSA:3.40.50.620 158 292 1.6E-18 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 PRINTS PR01438 Universal stress protein signature 96 108 3.6E-13 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 PRINTS PR01438 Universal stress protein signature 114 136 3.6E-13 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS49915 329f98d91915c6dd61efe8f7eca0e9cd 295 PRINTS PR01438 Universal stress protein signature 2 20 3.6E-13 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS49650 c91a218a3283e02a546a2e0945fe6f3e 214 SUPERFAMILY SSF54001 78 150 7.16E-6 T 17-03-2017 SHXM_RS49650 c91a218a3283e02a546a2e0945fe6f3e 214 Gene3D G3DSA:3.90.1720.10 58 150 1.3E-6 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS42325 163bc607d9320377a65cc6ebc1169b39 158 Gene3D G3DSA:3.10.450.50 3 149 2.3E-22 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS42325 163bc607d9320377a65cc6ebc1169b39 158 Pfam PF13577 SnoaL-like domain 4 147 1.7E-20 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS42325 163bc607d9320377a65cc6ebc1169b39 158 SUPERFAMILY SSF54427 2 153 9.54E-30 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS32470 fda5471d7a42a5cc6845d071ff866cbc 497 Pfam PF08031 Berberine and berberine like 449 493 1.9E-19 T 17-03-2017 IPR012951 Berberine/berberine-like GO:0016491|GO:0050660|GO:0055114 SHXM_RS32470 fda5471d7a42a5cc6845d071ff866cbc 497 Pfam PF01565 FAD binding domain 78 208 3.8E-25 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS32470 fda5471d7a42a5cc6845d071ff866cbc 497 ProSitePatterns PS00862 Oxygen oxidoreductases covalent FAD-binding site. 78 111 - T 17-03-2017 IPR006093 Oxygen oxidoreductase covalent FAD-binding site GO:0016491|GO:0055114 SHXM_RS32470 fda5471d7a42a5cc6845d071ff866cbc 497 SUPERFAMILY SSF56176 51 248 5.61E-45 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS32470 fda5471d7a42a5cc6845d071ff866cbc 497 Gene3D G3DSA:3.30.43.10 70 134 1.6E-11 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS32470 fda5471d7a42a5cc6845d071ff866cbc 497 Gene3D G3DSA:3.30.465.10 135 249 6.6E-9 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS46325 46bab396910e3728b02f3588fe460182 506 Pfam PF00171 Aldehyde dehydrogenase family 40 500 6.1E-163 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS46325 46bab396910e3728b02f3588fe460182 506 SUPERFAMILY SSF53720 20 504 2.49E-159 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS46325 46bab396910e3728b02f3588fe460182 506 Gene3D G3DSA:3.40.605.10 26 287 2.5E-95 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS46325 46bab396910e3728b02f3588fe460182 506 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 301 312 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS46325 46bab396910e3728b02f3588fe460182 506 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 273 280 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS46325 46bab396910e3728b02f3588fe460182 506 Gene3D G3DSA:3.40.309.10 288 476 2.2E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS29100 4fdc825bab7836793affdfb41a914545 159 SMART SM00422 30 99 5.5E-26 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS29100 4fdc825bab7836793affdfb41a914545 159 ProSitePatterns PS00552 MerR-type HTH domain signature. 33 55 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS29100 4fdc825bab7836793affdfb41a914545 159 SUPERFAMILY SSF46955 30 119 3.62E-19 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS29100 4fdc825bab7836793affdfb41a914545 159 Pfam PF13411 MerR HTH family regulatory protein 30 97 1.6E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS29100 4fdc825bab7836793affdfb41a914545 159 Gene3D G3DSA:1.10.1660.10 31 131 7.7E-22 T 17-03-2017 SHXM_RS40115 31c6b92aa5c1905dcd13e3ec746869d8 234 Pfam PF02687 FtsX-like permease family 129 227 4.0E-10 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS12005 99540a71d4041ce2ba58648b608c76e2 142 Pfam PF01220 Dehydroquinase class II 4 135 6.1E-44 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS12005 99540a71d4041ce2ba58648b608c76e2 142 SUPERFAMILY SSF52304 3 140 8.24E-48 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS12005 99540a71d4041ce2ba58648b608c76e2 142 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 142 50.627 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS12005 99540a71d4041ce2ba58648b608c76e2 142 Gene3D G3DSA:3.40.50.9100 3 140 7.6E-48 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS12005 99540a71d4041ce2ba58648b608c76e2 142 PIRSF PIRSF001399 1 142 5.3E-45 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS12005 99540a71d4041ce2ba58648b608c76e2 142 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 17 137 2.0E-37 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 Gene3D G3DSA:1.10.10.10 113 177 1.1E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 SUPERFAMILY SSF88659 114 175 3.71E-14 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 Pfam PF08281 Sigma-70, region 4 121 172 1.0E-12 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 Gene3D G3DSA:1.10.1740.10 5 108 8.7E-27 T 17-03-2017 SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 SUPERFAMILY SSF88946 5 94 1.57E-21 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 15 174 3.4E-19 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS18380 f21626d08563b5370bef7b5d736662d5 213 Pfam PF04542 Sigma-70 region 2 20 84 3.3E-13 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS13095 316c2594b30d0de4add466239d6076a3 176 Pfam PF00293 NUDIX domain 41 154 9.5E-18 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS13095 316c2594b30d0de4add466239d6076a3 176 Gene3D G3DSA:3.90.79.10 2 172 2.7E-39 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS13095 316c2594b30d0de4add466239d6076a3 176 SUPERFAMILY SSF55811 3 173 6.09E-40 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS13095 316c2594b30d0de4add466239d6076a3 176 ProSitePatterns PS00893 Nudix box signature. 74 95 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS00225 1247a3901c838a4d848dd0149406b5c6 111 Pfam PF13443 Cro/C1-type HTH DNA-binding domain 10 77 3.8E-22 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS00225 1247a3901c838a4d848dd0149406b5c6 111 Gene3D G3DSA:1.10.260.40 35 79 6.6E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS42465 250ee966351502b975913f6eea5f27bc 282 Gene3D G3DSA:3.90.850.10 38 243 8.8E-65 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS42465 250ee966351502b975913f6eea5f27bc 282 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 47 241 5.7E-50 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS42465 250ee966351502b975913f6eea5f27bc 282 SUPERFAMILY SSF56529 37 242 3.4E-61 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 SUPERFAMILY SSF51735 1 242 2.63E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 5.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 5.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 5.8E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 Gene3D G3DSA:3.40.50.720 1 232 5.0E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 Pfam PF00106 short chain dehydrogenase 7 198 1.8E-52 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 142 170 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 6.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 6.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 6.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 6.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15290 8c67fe185b0a768bdacae7c212a4ea02 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 6.1E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44255 2e65aa510c5e96d99d6c4da67e5c1f61 187 Gene3D G3DSA:3.40.430.10 3 185 1.6E-31 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS44255 2e65aa510c5e96d99d6c4da67e5c1f61 187 Pfam PF01872 RibD C-terminal domain 3 180 5.5E-20 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS44255 2e65aa510c5e96d99d6c4da67e5c1f61 187 SUPERFAMILY SSF53597 2 186 1.28E-31 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS01155 7e5b11e750e9f379961e3627f4aec86d 357 Pfam PF05368 NmrA-like family 9 241 4.0E-27 T 17-03-2017 IPR008030 NmrA-like domain Reactome: R-HSA-70635 SHXM_RS01155 7e5b11e750e9f379961e3627f4aec86d 357 Gene3D G3DSA:3.40.50.720 5 237 1.5E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01155 7e5b11e750e9f379961e3627f4aec86d 357 SUPERFAMILY SSF51735 6 253 2.17E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 Gene3D G3DSA:1.10.10.10 125 225 1.2E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 Pfam PF00072 Response regulator receiver domain 4 114 5.9E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 SUPERFAMILY SSF52172 1 128 2.42E-40 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 SUPERFAMILY SSF46894 125 224 3.97E-30 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 Gene3D G3DSA:3.40.50.2300 2 124 3.0E-39 T 17-03-2017 SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 223 3.7E-28 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 SMART SM00862 147 223 4.4E-29 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS24330 5a6f6526f52bf2587e333aaf1a2b015d 226 SMART SM00448 2 113 3.0E-41 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS50240 de28c78e97feded62528e4e8e419cde8 60 Gene3D G3DSA:3.40.50.1820 2 59 2.9E-6 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS50240 de28c78e97feded62528e4e8e419cde8 60 SUPERFAMILY SSF53474 2 59 1.5E-8 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39255 53e17b2b2dd73209043e86723f16b6d8 147 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 19 135 6.4E-24 T 17-03-2017 IPR018727 Protein of unknown function DUF2267 SHXM_RS09775 656a2d35f08b1b67c5713b09c7598f0b 205 Pfam PF09299 Mu transposase, C-terminal 61 115 3.5E-7 T 17-03-2017 IPR015378 Transposase-like, Mu, C-terminal SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 SUPERFAMILY SSF53822 66 329 5.89E-59 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 Gene3D G3DSA:3.40.50.2300 63 168 7.3E-28 T 17-03-2017 SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 SUPERFAMILY SSF47413 3 50 6.94E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 48 1.9E-9 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 Gene3D G3DSA:1.10.260.40 3 48 4.5E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 Gene3D G3DSA:3.40.50.2300 169 328 1.3E-44 T 17-03-2017 SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 SMART SM00354 2 76 9.2E-10 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS05945 4f7bed62f74cf7c8ec46e8c37d4576d2 349 Pfam PF13377 Periplasmic binding protein-like domain 169 326 4.4E-36 T 17-03-2017 SHXM_RS09590 b7400aa7206549d56cbbbd3d62dbce57 400 Gene3D G3DSA:1.10.150.130 44 151 3.3E-8 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS09590 b7400aa7206549d56cbbbd3d62dbce57 400 SUPERFAMILY SSF56349 195 369 5.59E-32 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS09590 b7400aa7206549d56cbbbd3d62dbce57 400 Gene3D G3DSA:1.10.443.10 208 368 3.8E-31 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS09590 b7400aa7206549d56cbbbd3d62dbce57 400 Pfam PF00589 Phage integrase family 218 362 6.6E-16 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS26215 9b2df9059b7c958fb851abfa98fe3838 149 ProSitePatterns PS00893 Nudix box signature. 52 73 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS26215 9b2df9059b7c958fb851abfa98fe3838 149 Pfam PF00293 NUDIX domain 18 138 7.0E-17 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS26215 9b2df9059b7c958fb851abfa98fe3838 149 Gene3D G3DSA:3.90.79.10 17 144 3.3E-30 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS26215 9b2df9059b7c958fb851abfa98fe3838 149 SUPERFAMILY SSF55811 15 146 6.91E-28 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS02150 d713a35b225db9a1c3ae5080d8b1315f 85 ProDom PD000887 CARRIER ACYL PHOSPHOPANTETHEINE ACP ACID FATTY BIOSYNTHESIS LIPID SYNTHESIS CHLOROPLAST 37 80 0.008 T 17-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS02150 d713a35b225db9a1c3ae5080d8b1315f 85 SUPERFAMILY SSF47336 3 80 3.66E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02150 d713a35b225db9a1c3ae5080d8b1315f 85 Gene3D G3DSA:1.10.1200.10 3 80 1.2E-17 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS02150 d713a35b225db9a1c3ae5080d8b1315f 85 Pfam PF00550 Phosphopantetheine attachment site 10 75 1.0E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS19495 d3b5832a81d778d23271f22c8a955c25 419 Pfam PF04261 Dyp-type peroxidase family 60 407 5.4E-115 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS19495 d3b5832a81d778d23271f22c8a955c25 419 SUPERFAMILY SSF54909 55 411 7.69E-90 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS19495 d3b5832a81d778d23271f22c8a955c25 419 TIGRFAM TIGR01412 tat_substr_1: Tat-translocated enzyme 6 418 1.0E-167 T 17-03-2017 IPR006313 Deferrochelatase/peroxidase EfeB GO:0004601|GO:0015684|GO:0020037|GO:0033212 SHXM_RS19495 d3b5832a81d778d23271f22c8a955c25 419 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 60 407 1.2E-98 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS18625 095238e60dbc18d770282d39acc7ed3d 809 Pfam PF01841 Transglutaminase-like superfamily 439 554 1.7E-25 T 17-03-2017 IPR002931 Transglutaminase-like SHXM_RS18625 095238e60dbc18d770282d39acc7ed3d 809 SUPERFAMILY SSF54001 423 561 6.59E-33 T 17-03-2017 SHXM_RS18625 095238e60dbc18d770282d39acc7ed3d 809 Gene3D G3DSA:3.90.260.10 416 567 3.3E-22 T 17-03-2017 IPR002931 Transglutaminase-like SHXM_RS18625 095238e60dbc18d770282d39acc7ed3d 809 SMART SM00460 486 556 6.2E-22 T 17-03-2017 IPR002931 Transglutaminase-like SHXM_RS16745 036adfe83f70dff7b5cf93f1f3983fb9 358 TIGRFAM TIGR01686 FkbH: FkbH domain 7 316 4.9E-113 T 17-03-2017 IPR010037 FkbH domain SHXM_RS16745 036adfe83f70dff7b5cf93f1f3983fb9 358 Gene3D G3DSA:3.40.50.1000 6 115 1.6E-18 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS16745 036adfe83f70dff7b5cf93f1f3983fb9 358 SUPERFAMILY SSF55729 183 292 6.01E-6 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS16745 036adfe83f70dff7b5cf93f1f3983fb9 358 Gene3D G3DSA:3.40.630.30 183 315 1.4E-5 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS16745 036adfe83f70dff7b5cf93f1f3983fb9 358 TIGRFAM TIGR01681 HAD-SF-IIIC: HAD phosphatase, family IIIC 9 118 6.5E-19 T 17-03-2017 IPR010033 HAD-superfamily phosphatase, subfamily IIIC SHXM_RS16745 036adfe83f70dff7b5cf93f1f3983fb9 358 SUPERFAMILY SSF56784 8 111 1.36E-14 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19740 6aa550f36fee37064b1dd434a576a57c 284 SUPERFAMILY SSF54637 11 158 2.42E-37 T 17-03-2017 IPR029069 HotDog domain SHXM_RS19740 6aa550f36fee37064b1dd434a576a57c 284 Pfam PF01575 MaoC like domain 161 262 3.0E-32 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS19740 6aa550f36fee37064b1dd434a576a57c 284 Gene3D G3DSA:3.10.129.10 146 280 3.9E-45 T 17-03-2017 IPR029069 HotDog domain SHXM_RS19740 6aa550f36fee37064b1dd434a576a57c 284 Gene3D G3DSA:3.10.129.10 1 145 1.2E-48 T 17-03-2017 IPR029069 HotDog domain SHXM_RS19740 6aa550f36fee37064b1dd434a576a57c 284 Pfam PF13452 N-terminal half of MaoC dehydratase 15 132 9.4E-14 T 17-03-2017 SHXM_RS19740 6aa550f36fee37064b1dd434a576a57c 284 SUPERFAMILY SSF54637 160 278 9.79E-32 T 17-03-2017 IPR029069 HotDog domain SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 Gene3D G3DSA:1.10.10.10 11 71 7.0E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 Gene3D G3DSA:3.30.420.40 214 369 4.3E-49 T 17-03-2017 SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 Pfam PF00480 ROK family 78 386 2.3E-59 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 Gene3D G3DSA:3.30.420.40 77 213 4.0E-43 T 17-03-2017 SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 SUPERFAMILY SSF53067 76 389 8.1E-60 T 17-03-2017 SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 SUPERFAMILY SSF46785 8 69 2.55E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14215 42de57e96e5c1468a7e7038189062edc 393 ProSitePatterns PS01125 ROK family signature. 209 236 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Gene3D G3DSA:3.40.50.261 382 538 3.6E-30 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 SUPERFAMILY SSF52210 545 691 9.94E-29 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 402 539 7.0E-50 T 17-03-2017 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Gene3D G3DSA:3.40.50.261 542 688 7.0E-12 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Gene3D G3DSA:3.40.50.720 254 381 6.1E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 SUPERFAMILY SSF52210 382 539 5.23E-38 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 SMART SM00881 258 353 1.0E-35 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 SUPERFAMILY SSF56059 27 239 4.47E-43 T 17-03-2017 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Pfam PF13380 CoA binding domain 262 380 6.3E-25 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Gene3D G3DSA:3.30.1490.20 37 65 4.5E-6 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 Pfam PF13549 ATP-grasp domain 15 233 8.5E-80 T 17-03-2017 SHXM_RS14130 1cef28bcdc9a4f0440e0ce447b463d10 711 SUPERFAMILY SSF51735 255 390 3.12E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49205 380a2155c8fa3448fe02f1ef20427e8c 131 Gene3D G3DSA:3.40.630.30 12 124 2.6E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS49205 380a2155c8fa3448fe02f1ef20427e8c 131 Pfam PF00583 Acetyltransferase (GNAT) family 48 122 3.4E-11 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS49205 380a2155c8fa3448fe02f1ef20427e8c 131 SUPERFAMILY SSF55729 12 124 4.73E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:3.30.300.30 450 568 2.0E-32 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Pfam PF00501 AMP-binding enzyme 60 454 3.0E-86 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 SUPERFAMILY SSF51161 753 878 2.36E-16 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 TIGRFAM TIGR01733 AA-adenyl-dom: amino acid adenylation domain 77 478 1.2E-121 T 17-03-2017 IPR010071 Amino acid adenylation domain SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:1.10.1200.10 569 636 5.4E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 TIGRFAM TIGR02353 NRPS_term_dom: non-ribosomal peptide synthetase terminal domain of unknown function 663 1364 1.7E-200 T 17-03-2017 IPR012728 Non-ribosomal peptide synthetase, C-terminal SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 822 849 0.0048 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Pfam PF14602 Hexapeptide repeat of succinyl-transferase 1315 1343 0.21 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Pfam PF13193 AMP-binding enzyme C-terminal domain 462 537 1.9E-5 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:2.30.38.10 363 447 6.5E-20 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:3.40.50.980 60 218 7.4E-40 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 SUPERFAMILY SSF47336 558 633 1.09E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:2.160.10.10 1273 1366 2.7E-21 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:2.160.10.10 720 802 9.1E-11 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:2.160.10.10 803 879 7.7E-8 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 ProSitePatterns PS00455 Putative AMP-binding domain signature. 203 214 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Pfam PF00550 Phosphopantetheine attachment site 568 631 1.2E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 SUPERFAMILY SSF51161 1235 1367 7.07E-17 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:2.160.10.10 1046 1129 1.1E-4 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 SUPERFAMILY SSF56801 59 578 6.41E-138 T 17-03-2017 SHXM_RS45975 234a72fd2b1d55c56a435deed76f8be6 1377 Gene3D G3DSA:3.40.50.980 222 362 2.3E-36 T 17-03-2017 SHXM_RS47700 721aba2097749dc37d8e9148042c0cc0 293 SUPERFAMILY SSF53474 9 290 1.7E-66 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47700 721aba2097749dc37d8e9148042c0cc0 293 Gene3D G3DSA:3.40.50.1820 10 290 1.1E-63 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47700 721aba2097749dc37d8e9148042c0cc0 293 PRINTS PR00412 Epoxide hydrolase signature 100 113 4.8E-9 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS47700 721aba2097749dc37d8e9148042c0cc0 293 PRINTS PR00412 Epoxide hydrolase signature 37 55 4.8E-9 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS47700 721aba2097749dc37d8e9148042c0cc0 293 PRINTS PR00412 Epoxide hydrolase signature 266 288 4.8E-9 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS47700 721aba2097749dc37d8e9148042c0cc0 293 Pfam PF00561 alpha/beta hydrolase fold 31 129 6.1E-20 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 254 364 1.1E-33 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 Gene3D G3DSA:3.40.47.10 6 259 2.4E-50 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 SMART SM00825 Beta-ketoacyl synthase 9 410 6.4E-15 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 SUPERFAMILY SSF53901 7 251 3.29E-48 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 7 246 2.4E-34 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 SUPERFAMILY SSF53901 217 407 6.48E-63 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23125 2b70c17df76782ad0a12bf3dc9fba49b 413 Gene3D G3DSA:3.40.47.10 263 407 1.3E-51 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37330 ca79af5582070f00fe0a610c21527798 312 Pfam PF01715 IPP transferase 43 285 1.2E-73 T 17-03-2017 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 SHXM_RS37330 ca79af5582070f00fe0a610c21527798 312 SUPERFAMILY SSF52540 10 153 1.5E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37330 ca79af5582070f00fe0a610c21527798 312 TIGRFAM TIGR00174 miaA: tRNA dimethylallyltransferase 10 289 2.0E-73 T 17-03-2017 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 SHXM_RS37330 ca79af5582070f00fe0a610c21527798 312 Hamap MF_00185 tRNA dimethylallyltransferase [miaA]. 10 300 27.3 T 17-03-2017 IPR018022 tRNA dimethylallyltransferase GO:0008033 KEGG: 00908+2.5.1.75|MetaCyc: PWY-2781|Reactome: R-HSA-6782315|Reactome: R-HSA-6787450 SHXM_RS37330 ca79af5582070f00fe0a610c21527798 312 Gene3D G3DSA:1.10.287.890 201 282 2.0E-24 T 17-03-2017 SHXM_RS37330 ca79af5582070f00fe0a610c21527798 312 Gene3D G3DSA:3.40.50.300 7 176 6.8E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07375 170ea9e36aedec86f5a082f591c9c831 175 Pfam PF01381 Helix-turn-helix 51 89 1.1E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS07375 170ea9e36aedec86f5a082f591c9c831 175 SUPERFAMILY SSF47413 53 94 1.9E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS07375 170ea9e36aedec86f5a082f591c9c831 175 Gene3D G3DSA:1.10.260.40 53 133 9.0E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS18075 123694241b697aad63a6f97049eed75a 314 Pfam PF09754 PAC2 family 35 253 1.9E-36 T 17-03-2017 IPR019151 Proteasome assembly chaperone 2 SHXM_RS18075 123694241b697aad63a6f97049eed75a 314 Gene3D G3DSA:1.10.287.100 235 275 2.2E-9 T 17-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 SHXM_RS18075 123694241b697aad63a6f97049eed75a 314 PIRSF PIRSF028754 13 314 9.1E-105 T 17-03-2017 IPR008492 Protein of unknown function DUF774 SHXM_RS18075 123694241b697aad63a6f97049eed75a 314 SUPERFAMILY SSF159659 24 277 1.96E-72 T 17-03-2017 SHXM_RS28340 96db8ea2262859683ada5359fb2d341a 411 SMART SM00752 20 365 2.4E-85 T 17-03-2017 IPR011020 HTTM Reactome: R-HSA-159740 SHXM_RS32115 1e147c8c6243759330101d1da3746179 119 Gene3D G3DSA:3.30.565.10 24 115 1.4E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS32115 1e147c8c6243759330101d1da3746179 119 SUPERFAMILY SSF55874 21 115 5.22E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20015 a69aff768759b5170e88ca1553a5985a 229 Pfam PF09335 SNARE associated Golgi protein 65 171 9.6E-9 T 17-03-2017 IPR032816 SNARE associated Golgi protein SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00862 27 101 4.5E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Pfam PF13424 Tetratricopeptide repeat 776 834 3.5E-11 T 17-03-2017 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 PRINTS PR00364 Disease resistance protein signature 471 485 1.5E-8 T 17-03-2017 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 PRINTS PR00364 Disease resistance protein signature 309 324 1.5E-8 T 17-03-2017 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 PRINTS PR00364 Disease resistance protein signature 386 400 1.5E-8 T 17-03-2017 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Pfam PF00931 NB-ARC domain 292 529 3.2E-14 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SUPERFAMILY SSF46894 14 99 7.65E-12 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Gene3D G3DSA:1.25.40.10 179 240 3.4E-25 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Gene3D G3DSA:1.25.40.10 721 953 3.4E-25 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SUPERFAMILY SSF52540 274 537 5.07E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SUPERFAMILY SSF48452 740 954 1.93E-23 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00028 884 917 47.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00028 763 797 390.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00028 923 956 0.38 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00028 844 877 26.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00028 804 837 4.9 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM00028 723 756 190.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Gene3D G3DSA:1.10.10.10 34 100 1.1E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SUPERFAMILY SSF48452 107 267 2.6E-32 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Pfam PF00486 Transcriptional regulatory protein, C terminal 33 100 9.0E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 Pfam PF03704 Bacterial transcriptional activator domain 108 252 9.7E-41 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS31820 001b7c8c2c59b2e5a23f6fb665e5e052 974 SMART SM01043 108 252 4.2E-47 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS05320 f1406c21e6d0ea1c4408a7d7f4d629cd 78 SMART SM01294 12 78 2.6E-4 T 17-03-2017 SHXM_RS05320 f1406c21e6d0ea1c4408a7d7f4d629cd 78 SUPERFAMILY SSF47336 4 78 3.8E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05320 f1406c21e6d0ea1c4408a7d7f4d629cd 78 Pfam PF00550 Phosphopantetheine attachment site 13 78 2.6E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05320 f1406c21e6d0ea1c4408a7d7f4d629cd 78 Gene3D G3DSA:1.10.1200.10 10 78 4.9E-24 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05320 f1406c21e6d0ea1c4408a7d7f4d629cd 78 ProSitePatterns PS00012 Phosphopantetheine attachment site. 38 53 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS05320 f1406c21e6d0ea1c4408a7d7f4d629cd 78 SMART SM00823 Phosphopantetheine attachment site 11 78 5.5E-26 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 Gene3D G3DSA:2.40.37.10 266 408 1.5E-27 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 PRINTS PR01182 Ornithine decarboxylase signature 343 353 4.9E-5 T 17-03-2017 IPR002433 Ornithine decarboxylase GO:0006596 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 PRINTS PR01182 Ornithine decarboxylase signature 93 117 4.9E-5 T 17-03-2017 IPR002433 Ornithine decarboxylase GO:0006596 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 PRINTS PR01182 Ornithine decarboxylase signature 49 76 4.9E-5 T 17-03-2017 IPR002433 Ornithine decarboxylase GO:0006596 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 SUPERFAMILY SSF51419 21 284 4.25E-42 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 38 282 1.2E-23 T 17-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 Gene3D G3DSA:3.20.20.10 39 265 2.0E-41 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 SUPERFAMILY SSF50621 267 408 9.84E-28 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 287 396 1.3E-8 T 17-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 71 83 3.7E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 51 69 3.7E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS15430 ae91145aec6a2a0867ca7ff1aa0f434b 420 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 272 291 3.7E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS36270 43bd8ef765354614bc0c8e915108a147 137 SUPERFAMILY SSF103196 2 125 1.44E-31 T 17-03-2017 SHXM_RS36270 43bd8ef765354614bc0c8e915108a147 137 Pfam PF03259 Roadblock/LC7 domain 9 99 5.2E-25 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS36270 43bd8ef765354614bc0c8e915108a147 137 SMART SM00960 9 99 9.0E-33 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS36270 43bd8ef765354614bc0c8e915108a147 137 Gene3D G3DSA:3.30.450.30 3 123 6.6E-25 T 17-03-2017 SHXM_RS34595 c7f45b5d80c2bcf6f8b28eba5408366a 276 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 90 263 3.8E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34595 c7f45b5d80c2bcf6f8b28eba5408366a 276 SUPERFAMILY SSF161098 2 276 5.51E-72 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34595 c7f45b5d80c2bcf6f8b28eba5408366a 276 Gene3D G3DSA:1.10.3720.10 3 263 2.5E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47875 57823b6cf5fce60150655cc833b38c3e 298 Pfam PF13560 Helix-turn-helix domain 13 89 1.1E-11 T 17-03-2017 SHXM_RS47875 57823b6cf5fce60150655cc833b38c3e 298 SMART SM00530 9 86 2.4E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS47875 57823b6cf5fce60150655cc833b38c3e 298 Gene3D G3DSA:1.10.260.40 8 85 9.6E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47875 57823b6cf5fce60150655cc833b38c3e 298 SUPERFAMILY SSF47413 35 83 2.25E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS26875 e77fd1e9af6446250371748942b67da7 524 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 242 248 - T 17-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SHXM_RS26875 e77fd1e9af6446250371748942b67da7 524 SUPERFAMILY SSF53335 171 308 2.96E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26875 e77fd1e9af6446250371748942b67da7 524 Pfam PF05175 Methyltransferase small domain 173 249 7.2E-13 T 17-03-2017 IPR007848 Methyltransferase small domain GO:0008168 SHXM_RS26875 e77fd1e9af6446250371748942b67da7 524 Gene3D G3DSA:3.40.50.150 171 331 8.2E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 1.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 1.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 1.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 SUPERFAMILY SSF46785 5 111 1.27E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 64 3.1E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 Gene3D G3DSA:1.10.10.10 6 83 2.1E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 SUPERFAMILY SSF53850 92 299 6.39E-38 T 17-03-2017 SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 Gene3D G3DSA:3.40.190.10 94 177 4.3E-16 T 17-03-2017 SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 Pfam PF03466 LysR substrate binding domain 91 295 1.2E-37 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS40815 e4b4128240316fe3fd53ba53645f032e 302 Gene3D G3DSA:3.40.190.10 178 265 5.6E-18 T 17-03-2017 SHXM_RS42805 59ff3b3d7c07553f200402fe082f0906 354 SUPERFAMILY SSF56796 19 328 1.13E-88 T 17-03-2017 SHXM_RS42805 59ff3b3d7c07553f200402fe082f0906 354 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 17 347 30.476 T 17-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS42805 59ff3b3d7c07553f200402fe082f0906 354 Gene3D G3DSA:3.40.50.1970 18 178 2.0E-47 T 17-03-2017 SHXM_RS42805 59ff3b3d7c07553f200402fe082f0906 354 Pfam PF01761 3-dehydroquinate synthase 75 316 8.3E-79 T 17-03-2017 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS42805 59ff3b3d7c07553f200402fe082f0906 354 Gene3D G3DSA:1.20.1090.10 179 345 2.2E-39 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 88 108 4.6E-6 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 270 292 4.6E-6 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 434 456 4.6E-6 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 8 664 5.6E-137 T 17-03-2017 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 74 124 9.9E-11 T 17-03-2017 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 86 111 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 114 134 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 320 332 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 161 182 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 435 454 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 252 278 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 230 251 7.8E-48 T 17-03-2017 SHXM_RS30960 915041c2a1b8dcfc09810618cccaaf8e 672 Pfam PF00361 Proton-conducting membrane transporter 137 412 1.0E-75 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS26610 7643932904dba69fee5671c6ea68a453 431 SUPERFAMILY SSF53448 44 329 8.53E-38 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS26610 7643932904dba69fee5671c6ea68a453 431 Pfam PF13641 Glycosyltransferase like family 2 54 283 2.8E-38 T 17-03-2017 SHXM_RS26610 7643932904dba69fee5671c6ea68a453 431 Gene3D G3DSA:3.90.550.10 54 299 6.7E-22 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS39555 ee9aca9292e094a1810cfc9181a11870 198 Pfam PF13556 PucR C-terminal helix-turn-helix domain 119 175 1.3E-12 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS39555 ee9aca9292e094a1810cfc9181a11870 198 Gene3D G3DSA:1.10.10.60 124 155 5.4E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05475 9c8a4054984eec5dae7a21803601e02d 106 Pfam PF07978 NIPSNAP 3 103 1.5E-14 T 17-03-2017 IPR012577 NIPSNAP SHXM_RS05475 9c8a4054984eec5dae7a21803601e02d 106 Gene3D G3DSA:3.30.70.900 1 91 1.2E-9 T 17-03-2017 SHXM_RS05475 9c8a4054984eec5dae7a21803601e02d 106 SUPERFAMILY SSF54909 1 99 1.3E-20 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS10345 b1a383dca49cbb31a5909c0a320ff80c 135 Pfam PF13380 CoA binding domain 18 131 8.5E-35 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS10345 b1a383dca49cbb31a5909c0a320ff80c 135 SUPERFAMILY SSF51735 17 135 6.4E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10345 b1a383dca49cbb31a5909c0a320ff80c 135 SMART SM00881 12 105 1.4E-16 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS10345 b1a383dca49cbb31a5909c0a320ff80c 135 Gene3D G3DSA:3.40.50.720 17 134 6.6E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 2.9E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 2.9E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 220 240 2.9E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 2.9E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 2.9E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 2.9E-27 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 Gene3D G3DSA:3.40.50.720 3 254 6.2E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 251 4.0E-46 T 17-03-2017 SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 9 192 3.0E-4 T 17-03-2017 SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 SUPERFAMILY SSF51735 4 254 5.23E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 1.2E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 1.2E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47055 e5bd65df807c356fcf24503b2ce05956 305 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 1.2E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25665 1f1a755617580eb54518f4c89b790355 331 SUPERFAMILY SSF51430 1 321 6.68E-97 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS25665 1f1a755617580eb54518f4c89b790355 331 Gene3D G3DSA:3.20.20.100 1 319 5.0E-99 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS25665 1f1a755617580eb54518f4c89b790355 331 Pfam PF00248 Aldo/keto reductase family 15 318 2.5E-71 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS36870 f20d2d5d19a14481e92c09f847a0a930 433 Pfam PF02163 Peptidase family M50 13 387 8.3E-48 T 17-03-2017 IPR008915 Peptidase M50 GO:0004222|GO:0006508 Reactome: R-HSA-1655829|Reactome: R-HSA-381033 SHXM_RS36870 f20d2d5d19a14481e92c09f847a0a930 433 SUPERFAMILY SSF50156 128 237 2.23E-14 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS36870 f20d2d5d19a14481e92c09f847a0a930 433 Gene3D G3DSA:2.30.42.10 122 237 4.8E-20 T 17-03-2017 IPR001478 PDZ domain GO:0005515 SHXM_RS26415 f0f9d3ee9bacce480a7deed2380b8d78 610 Pfam PF16995 Transmembrane region of lysyl-tRNA synthetase 28 224 8.7E-11 T 17-03-2017 IPR031553 Lysyl-tRNA synthetase, N-terminal transmembrane region KEGG: 00970+6.1.1.6 SHXM_RS26415 f0f9d3ee9bacce480a7deed2380b8d78 610 Pfam PF09924 Uncharacterised conserved protein (DUF2156) 247 556 4.1E-103 T 17-03-2017 IPR024320 Phosphatidylglycerol lysyltransferase, C-terminal SHXM_RS48310 c14fce273537fb444e1fc34d78fc0b5d 290 Gene3D G3DSA:3.40.50.10490 4 142 3.8E-16 T 17-03-2017 SHXM_RS48310 c14fce273537fb444e1fc34d78fc0b5d 290 SUPERFAMILY SSF53697 6 285 2.89E-44 T 17-03-2017 SHXM_RS48310 c14fce273537fb444e1fc34d78fc0b5d 290 Gene3D G3DSA:3.40.50.10490 251 284 2.2E-7 T 17-03-2017 SHXM_RS48310 c14fce273537fb444e1fc34d78fc0b5d 290 Gene3D G3DSA:3.40.50.10490 170 243 9.1E-20 T 17-03-2017 SHXM_RS09240 21e29f74f43913dfbfe4d43be64f9857 160 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 20 63 2.4E-12 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS09240 21e29f74f43913dfbfe4d43be64f9857 160 Gene3D G3DSA:1.10.10.60 26 52 2.1E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22220 10b47b70e8c2b6d71dfd53a02131d8b2 704 Pfam PF12805 FUSC-like inner membrane protein yccS 79 205 1.4E-8 T 17-03-2017 IPR032692 Integral membrane protein YccS, N-terminal SHXM_RS22220 10b47b70e8c2b6d71dfd53a02131d8b2 704 Pfam PF13515 Fusaric acid resistance protein-like 385 506 1.7E-15 T 17-03-2017 SHXM_RS01925 655398d38154791d989d68e6adcc79f7 171 Pfam PF00583 Acetyltransferase (GNAT) family 62 141 2.4E-15 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS01925 655398d38154791d989d68e6adcc79f7 171 Gene3D G3DSA:3.40.630.30 3 144 1.0E-26 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS01925 655398d38154791d989d68e6adcc79f7 171 SUPERFAMILY SSF55729 2 144 1.25E-26 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS11555 79bbf2ee507289e4c5c5fc733e6afb38 62 Pfam PF07498 Rho termination factor, N-terminal domain 33 59 1.9E-5 T 17-03-2017 IPR011112 Rho termination factor, N-terminal GO:0006353 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 4.8E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 4.8E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 4.8E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 Pfam PF13411 MerR HTH family regulatory protein 1 61 2.8E-19 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 Gene3D G3DSA:1.10.1660.10 55 116 5.0E-10 T 17-03-2017 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 Gene3D G3DSA:1.10.1660.10 1 54 4.3E-25 T 17-03-2017 SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 SUPERFAMILY SSF46955 1 112 7.33E-29 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS27925 d4eeb3cbac4f0f5221525cb32ecbccba 143 SMART SM00422 1 69 3.7E-25 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44650 716c883470b5c3011c491f0e5585672e 381 Pfam PF13550 Putative phage tail protein 293 354 8.9E-5 T 17-03-2017 IPR032876 Tip attachment protein J SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 Pfam PF00175 Oxidoreductase NAD-binding domain 399 495 2.7E-13 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 SUPERFAMILY SSF63380 291 386 1.79E-23 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 Gene3D G3DSA:2.40.30.10 287 385 4.7E-24 T 17-03-2017 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 SUPERFAMILY SSF52343 391 514 3.8E-27 T 17-03-2017 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 SUPERFAMILY SSF46458 153 280 1.23E-30 T 17-03-2017 IPR009050 Globin-like SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 Gene3D G3DSA:1.10.490.10 156 284 4.5E-40 T 17-03-2017 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 Pfam PF00042 Globin 155 246 3.9E-8 T 17-03-2017 IPR000971 Globin GO:0019825|GO:0020037 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 Pfam PF00970 Oxidoreductase FAD-binding domain 295 386 7.5E-11 T 17-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 Gene3D G3DSA:3.40.50.80 391 515 6.4E-28 T 17-03-2017 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 337 344 7.3E-5 T 17-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 422 431 7.3E-5 T 17-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00371 Flavoprotein pyridine nucleotide cytochrome reductase signature 397 416 7.3E-5 T 17-03-2017 IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase GO:0016491|GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00410 Phenol hydroxylase reductase family signature 397 416 3.6E-15 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00410 Phenol hydroxylase reductase family signature 422 431 3.6E-15 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00410 Phenol hydroxylase reductase family signature 484 492 3.6E-15 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS27890 37722daab28fe7ba944c6ef399b22423 524 PRINTS PR00410 Phenol hydroxylase reductase family signature 319 331 3.6E-15 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS13225 1c83634945924cae9caa1eee382706d8 288 Pfam PF01374 Glycosyl hydrolase family 46 66 275 2.4E-103 T 17-03-2017 IPR000400 Glycoside hydrolase, family 46 GO:0005576|GO:0005975|GO:0016977 KEGG: 00520+3.2.1.132 SHXM_RS13225 1c83634945924cae9caa1eee382706d8 288 Gene3D G3DSA:1.20.141.10 161 287 4.8E-66 T 17-03-2017 SHXM_RS13225 1c83634945924cae9caa1eee382706d8 288 PIRSF PIRSF036551 6 288 3.6E-110 T 17-03-2017 IPR000400 Glycoside hydrolase, family 46 GO:0005576|GO:0005975|GO:0016977 KEGG: 00520+3.2.1.132 SHXM_RS13225 1c83634945924cae9caa1eee382706d8 288 SUPERFAMILY SSF53955 52 287 1.94E-93 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS13225 1c83634945924cae9caa1eee382706d8 288 Gene3D G3DSA:3.30.386.10 45 160 1.3E-58 T 17-03-2017 IPR023099 Glycoside hydrolase, family 46, N-terminal GO:0005975|GO:0016977 KEGG: 00520+3.2.1.132 SHXM_RS35085 077eef6ae8bb7e184b4e5aec7b86dcc0 262 Pfam PF09517 Eco29kI restriction endonuclease 66 138 1.1E-7 T 17-03-2017 IPR018575 Restriction endonuclease, type II, Eco29kI SHXM_RS35085 077eef6ae8bb7e184b4e5aec7b86dcc0 262 Pfam PF01541 GIY-YIG catalytic domain 48 116 1.6E-6 T 17-03-2017 IPR000305 GIY-YIG nuclease superfamily SHXM_RS13435 303fc93f7973fdd75f6d9d0912b5898c 643 Pfam PF01066 CDP-alcohol phosphatidyltransferase 235 301 6.9E-9 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS13435 303fc93f7973fdd75f6d9d0912b5898c 643 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 279 301 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 SMART SM00421 156 213 6.3E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 Gene3D G3DSA:3.40.50.2300 1 159 3.0E-40 T 17-03-2017 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 Pfam PF00072 Response regulator receiver domain 4 115 5.0E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 SUPERFAMILY SSF52172 1 131 1.31E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 189 201 1.5E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 173 189 1.5E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 159 173 1.5E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 Pfam PF00196 Bacterial regulatory proteins, luxR family 158 213 8.4E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 SUPERFAMILY SSF46894 148 220 5.1E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 ProSitePatterns PS00622 LuxR-type HTH domain signature. 173 200 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 Gene3D G3DSA:1.10.10.10 160 218 2.7E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08720 7c0364ccc519bea969c3f694f1495816 227 SMART SM00448 2 115 1.5E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS42255 868b281c8f2ac07b5021ad79e686e91f 288 SMART SM00530 11 83 6.0E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS42255 868b281c8f2ac07b5021ad79e686e91f 288 Gene3D G3DSA:1.10.260.40 4 81 1.6E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS42255 868b281c8f2ac07b5021ad79e686e91f 288 SUPERFAMILY SSF47413 32 80 1.1E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS42255 868b281c8f2ac07b5021ad79e686e91f 288 Pfam PF13560 Helix-turn-helix domain 7 86 2.1E-16 T 17-03-2017 SHXM_RS25975 9bde8c85e4018054cef9869fc582aefe 85 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 62 7.0E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS25975 9bde8c85e4018054cef9869fc582aefe 85 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 2.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS25975 9bde8c85e4018054cef9869fc582aefe 85 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 2.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS25975 9bde8c85e4018054cef9869fc582aefe 85 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 2.6E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS25975 9bde8c85e4018054cef9869fc582aefe 85 Gene3D G3DSA:1.10.10.10 1 81 5.9E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25975 9bde8c85e4018054cef9869fc582aefe 85 SUPERFAMILY SSF46785 2 82 7.61E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11070 7d48366793072854fbec96a6d9f62d2c 311 Pfam PF11583 P-aminobenzoate N-oxygenase AurF 21 294 6.6E-81 T 17-03-2017 IPR025859 P-aminobenzoate N-oxygenase AurF SHXM_RS11070 7d48366793072854fbec96a6d9f62d2c 311 SUPERFAMILY SSF47240 35 239 4.68E-10 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS08940 56d1fa4114a9a2d771a3442e258e48f4 276 Pfam PF13546 DDE superfamily endonuclease 29 121 1.1E-14 T 17-03-2017 SHXM_RS08940 56d1fa4114a9a2d771a3442e258e48f4 276 SUPERFAMILY SSF53098 44 254 3.87E-12 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS27720 ff739921c2e595401eb1df64b863128a 430 SUPERFAMILY SSF103473 29 427 4.97E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27720 ff739921c2e595401eb1df64b863128a 430 Pfam PF07690 Major Facilitator Superfamily 44 388 2.6E-22 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS27720 ff739921c2e595401eb1df64b863128a 430 Gene3D G3DSA:1.20.1250.20 245 422 2.0E-15 T 17-03-2017 SHXM_RS27720 ff739921c2e595401eb1df64b863128a 430 Gene3D G3DSA:1.20.1250.20 45 210 2.1E-12 T 17-03-2017 SHXM_RS43180 0d3d6a46ff28449ca2531c93e27bc28d 418 Gene3D G3DSA:3.40.190.10 45 158 4.6E-20 T 17-03-2017 SHXM_RS43180 0d3d6a46ff28449ca2531c93e27bc28d 418 SUPERFAMILY SSF53850 24 415 8.28E-58 T 17-03-2017 SHXM_RS43180 0d3d6a46ff28449ca2531c93e27bc28d 418 Pfam PF01547 Bacterial extracellular solute-binding protein 46 330 8.9E-30 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS43180 0d3d6a46ff28449ca2531c93e27bc28d 418 Gene3D G3DSA:3.40.190.10 159 346 1.8E-26 T 17-03-2017 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 Gene3D G3DSA:3.30.565.10 315 476 5.8E-40 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 PRINTS PR00344 Bacterial sensor protein C-terminal signature 461 474 1.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 PRINTS PR00344 Bacterial sensor protein C-terminal signature 421 431 1.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 PRINTS PR00344 Bacterial sensor protein C-terminal signature 437 455 1.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 PRINTS PR00344 Bacterial sensor protein C-terminal signature 403 417 1.1E-14 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 Gene3D G3DSA:1.10.287.130 253 314 3.5E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 Pfam PF00672 HAMP domain 182 249 7.4E-14 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 Pfam PF00512 His Kinase A (phospho-acceptor) domain 262 328 6.5E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 SMART SM00304 201 253 5.2E-14 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 SMART SM00387 368 477 3.6E-33 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 SUPERFAMILY SSF158472 203 250 4.58E-8 T 17-03-2017 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 SUPERFAMILY SSF47384 245 328 6.28E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 SUPERFAMILY SSF55874 318 475 9.56E-37 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 369 476 3.3E-22 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24795 69c5e3066af63c1665b50a5511f187e0 542 SMART SM00388 261 328 1.9E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS32490 21327c4a14bff84a0e324dec62d7d3b6 156 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 6 86 5.0E-10 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS32490 21327c4a14bff84a0e324dec62d7d3b6 156 Gene3D G3DSA:3.10.180.10 6 116 1.9E-23 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS32490 21327c4a14bff84a0e324dec62d7d3b6 156 SUPERFAMILY SSF54593 6 120 7.65E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 Gene3D G3DSA:3.40.50.620 69 274 1.3E-67 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 92 114 2.5E-21 T 17-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 257 269 2.5E-21 T 17-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 207 222 2.5E-21 T 17-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 PRINTS PR01040 Tyrosyl-tRNA synthetase signature 224 246 2.5E-21 T 17-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 ProSitePatterns PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 88 98 - T 17-03-2017 IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 SUPERFAMILY SSF52374 75 364 2.95E-75 T 17-03-2017 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 Pfam PF00579 tRNA synthetases class I (W and Y) 81 358 8.1E-56 T 17-03-2017 IPR002305 Aminoacyl-tRNA synthetase, class Ic GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 Gene3D G3DSA:1.10.240.10 275 368 1.1E-24 T 17-03-2017 SHXM_RS17345 175a3822d8d42d5cbbec551a107e1130 472 TIGRFAM TIGR00234 tyrS: tyrosine--tRNA ligase 55 418 4.8E-85 T 17-03-2017 IPR002307 Tyrosine-tRNA ligase GO:0000166|GO:0004831|GO:0005524|GO:0005737|GO:0006437 KEGG: 00970+6.1.1.1 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 SUPERFAMILY SSF46894 846 909 4.42E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 Gene3D G3DSA:1.10.10.10 850 908 8.9E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 872 888 2.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 888 900 2.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 858 872 2.6E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 Gene3D G3DSA:1.25.40.10 393 512 6.9E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 Gene3D G3DSA:1.25.40.10 639 686 6.9E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 Pfam PF13191 AAA ATPase domain 2 189 1.1E-14 T 17-03-2017 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 Pfam PF00196 Bacterial regulatory proteins, luxR family 857 909 4.2E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 SMART SM00421 855 912 2.0E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 ProSitePatterns PS00622 LuxR-type HTH domain signature. 872 899 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 SUPERFAMILY SSF52540 18 66 7.35E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04950 362afc8b0acc98f63ae169c98893bdae 918 SUPERFAMILY SSF52540 132 221 7.35E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50145 8dfcfb719da01102dda6aeea55a92a6e 207 Gene3D G3DSA:3.40.710.10 11 189 2.1E-26 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS50145 8dfcfb719da01102dda6aeea55a92a6e 207 Pfam PF00144 Beta-lactamase 12 193 4.4E-15 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS50145 8dfcfb719da01102dda6aeea55a92a6e 207 SUPERFAMILY SSF56601 11 193 5.28E-39 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS21765 c396932dd2c74a1c3851970f83ab2a4f 490 ProSitePatterns PS00218 Amino acid permeases signature. 57 87 - T 17-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SHXM_RS21765 c396932dd2c74a1c3851970f83ab2a4f 490 PIRSF PIRSF006060 7 487 1.1E-76 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS21765 c396932dd2c74a1c3851970f83ab2a4f 490 Pfam PF00324 Amino acid permease 32 445 1.4E-116 T 17-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 1.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 1.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 1.4E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 6 172 0.0077 T 17-03-2017 SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 Gene3D G3DSA:3.40.50.720 1 238 2.6E-82 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 2.4E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 2.4E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 200 220 2.4E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 2.4E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 7 24 2.4E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 2.4E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 12 237 2.3E-61 T 17-03-2017 SHXM_RS10715 49cf08773ec53d52ff89554e1bc089bb 249 SUPERFAMILY SSF51735 1 238 9.66E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS00480 3aba4a436db17c52462892d39b577ab4 77 Pfam PF14408 Ribosomally synthesised peptide in actinomycetes 12 67 3.3E-17 T 17-03-2017 IPR025843 Ribosomally synthesized peptide in Actinomycetes SHXM_RS00480 3aba4a436db17c52462892d39b577ab4 77 TIGRFAM TIGR04186 GRASP_targ: putative ATP-grasp target RiPP 1 77 3.1E-16 T 17-03-2017 IPR026496 Putative ATP-grasp target RiPP SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 SMART SM00448 1 120 7.0E-8 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 Gene3D G3DSA:3.40.50.2300 2 148 6.8E-25 T 17-03-2017 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 Gene3D G3DSA:1.10.10.10 149 214 1.5E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 SUPERFAMILY SSF52172 2 166 8.52E-18 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 2.3E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 2.3E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 2.3E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 Pfam PF00072 Response regulator receiver domain 3 116 2.6E-12 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 SMART SM00421 148 210 4.0E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19230 5eb758202a5b2310e6526dd7ec64212f 215 Pfam PF00196 Bacterial regulatory proteins, luxR family 150 195 5.8E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19900 5594a3c3f186ab467b442db8fc92c8f0 398 Gene3D G3DSA:1.10.260.40 8 62 1.2E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19900 5594a3c3f186ab467b442db8fc92c8f0 398 SMART SM00530 9 64 0.0014 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS19900 5594a3c3f186ab467b442db8fc92c8f0 398 SUPERFAMILY SSF47413 9 62 2.78E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19900 5594a3c3f186ab467b442db8fc92c8f0 398 Gene3D G3DSA:1.25.40.10 198 356 2.3E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19900 5594a3c3f186ab467b442db8fc92c8f0 398 Pfam PF13560 Helix-turn-helix domain 5 64 7.1E-8 T 17-03-2017 SHXM_RS19900 5594a3c3f186ab467b442db8fc92c8f0 398 SUPERFAMILY SSF48452 154 358 7.21E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS24515 73011e93d1c724f11890d792da16d979 260 Pfam PF00005 ABC transporter 38 184 2.0E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS24515 73011e93d1c724f11890d792da16d979 260 ProSitePatterns PS00211 ABC transporters family signature. 157 171 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS24515 73011e93d1c724f11890d792da16d979 260 SMART SM00382 47 233 2.1E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS24515 73011e93d1c724f11890d792da16d979 260 SUPERFAMILY SSF52540 21 237 8.05E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24515 73011e93d1c724f11890d792da16d979 260 Gene3D G3DSA:3.40.50.300 21 237 1.4E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 144 158 1.9E-49 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 266 280 1.9E-49 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 222 239 1.9E-49 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 242 265 1.9E-49 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 201 221 1.9E-49 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 SUPERFAMILY SSF50494 123 294 2.12E-39 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 PIRSF PIRSF001134 8 301 1.7E-92 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 Gene3D G3DSA:3.30.300.50 51 112 5.7E-8 T 17-03-2017 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 ProSitePatterns PS00135 Serine proteases, trypsin family, serine active site. 251 262 - T 17-03-2017 IPR033116 Serine proteases, trypsin family, serine active site SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 Gene3D G3DSA:2.40.10.10 117 198 6.8E-29 T 17-03-2017 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 146 151 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 Gene3D G3DSA:2.40.10.10 199 288 9.4E-32 T 17-03-2017 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 Pfam PF00089 Trypsin 117 291 1.1E-11 T 17-03-2017 IPR001254 Serine proteases, trypsin domain GO:0004252|GO:0006508 SHXM_RS16900 44e705b0673911cd5258c7bb1309dbd5 301 Pfam PF02983 Alpha-lytic protease prodomain 47 100 3.0E-10 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 194 207 1.2E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 47 65 1.2E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 276 295 1.2E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01179 Ornithine/diaminopimelate/arginine (ODA) decarboxylase family signature 67 79 1.2E-9 T 17-03-2017 IPR000183 Ornithine/DAP/Arg decarboxylase GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 SUPERFAMILY SSF50621 253 408 9.42E-35 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 Gene3D G3DSA:2.40.37.10 272 409 5.0E-26 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 Gene3D G3DSA:3.20.20.10 26 271 2.2E-60 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 SUPERFAMILY SSF51419 24 289 3.34E-54 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01182 Ornithine decarboxylase signature 45 72 6.8E-7 T 17-03-2017 IPR002433 Ornithine decarboxylase GO:0006596 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01182 Ornithine decarboxylase signature 88 112 6.8E-7 T 17-03-2017 IPR002433 Ornithine decarboxylase GO:0006596 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 PRINTS PR01182 Ornithine decarboxylase signature 374 387 6.8E-7 T 17-03-2017 IPR002433 Ornithine decarboxylase GO:0006596 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 Pfam PF00278 Pyridoxal-dependent decarboxylase, C-terminal sheet domain 292 404 5.3E-10 T 17-03-2017 IPR022643 Orn/DAP/Arg decarboxylase 2, C-terminal GO:0003824 SHXM_RS16820 04ebc80fdef3f140b297ca9bdcc201cf 411 Pfam PF02784 Pyridoxal-dependent decarboxylase, pyridoxal binding domain 28 285 1.1E-27 T 17-03-2017 IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal GO:0003824 SHXM_RS37935 58da7d73c4a71bd5fb1d53ac1d106c7c 324 Gene3D G3DSA:3.20.20.330 5 323 1.9E-87 T 17-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 SHXM_RS37935 58da7d73c4a71bd5fb1d53ac1d106c7c 324 Pfam PF02574 Homocysteine S-methyltransferase 17 320 5.6E-67 T 17-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 SHXM_RS37935 58da7d73c4a71bd5fb1d53ac1d106c7c 324 SUPERFAMILY SSF82282 7 323 4.05E-76 T 17-03-2017 IPR003726 Homocysteine-binding domain Reactome: R-HSA-1614635 SHXM_RS29145 2a9fe12fbe25a98d0002e8014202b3e7 445 SUPERFAMILY SSF48452 216 432 8.95E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS29145 2a9fe12fbe25a98d0002e8014202b3e7 445 Gene3D G3DSA:1.10.260.40 29 84 7.5E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS29145 2a9fe12fbe25a98d0002e8014202b3e7 445 Gene3D G3DSA:1.25.40.10 215 428 3.5E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35945 a270cd9291f4cca3733dcb43fef7ca9d 460 SUPERFAMILY SSF143548 17 164 3.14E-44 T 17-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 SHXM_RS35945 a270cd9291f4cca3733dcb43fef7ca9d 460 Pfam PF03313 Serine dehydratase alpha chain 193 454 1.3E-103 T 17-03-2017 IPR005130 Serine dehydratase-like, alpha subunit SHXM_RS35945 a270cd9291f4cca3733dcb43fef7ca9d 460 Pfam PF03315 Serine dehydratase beta chain 4 162 4.4E-59 T 17-03-2017 IPR005131 Serine dehydratase beta chain GO:0003941|GO:0006094|GO:0051539 KEGG: 00260+4.3.1.17|KEGG: 00270+4.3.1.17 SHXM_RS35945 a270cd9291f4cca3733dcb43fef7ca9d 460 TIGRFAM TIGR00720 sda_mono: L-serine ammonia-lyase 3 457 2.6E-208 T 17-03-2017 IPR004644 Iron-sulphur-dependent L-serine dehydratase single chain form GO:0003941|GO:0006094 KEGG: 00260+4.3.1.17|KEGG: 00270+4.3.1.17 SHXM_RS35945 a270cd9291f4cca3733dcb43fef7ca9d 460 Gene3D G3DSA:3.30.1330.90 11 164 2.8E-54 T 17-03-2017 IPR029009 Allosteric substrate binding domain Reactome: R-HSA-977347 SHXM_RS04395 8b4c6efc43c95a9b70d94aa7aa8241b0 327 SUPERFAMILY SSF53474 149 325 3.15E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04395 8b4c6efc43c95a9b70d94aa7aa8241b0 327 TIGRFAM TIGR01840 esterase_phb: esterase, PHB depolymerase family 67 274 5.6E-41 T 17-03-2017 IPR010126 Esterase, PHB depolymerase GO:0005576|GO:0016787 SHXM_RS04395 8b4c6efc43c95a9b70d94aa7aa8241b0 327 Gene3D G3DSA:3.40.50.1820 32 322 3.8E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04395 8b4c6efc43c95a9b70d94aa7aa8241b0 327 Pfam PF10503 Esterase PHB depolymerase 70 233 3.2E-22 T 17-03-2017 IPR010126 Esterase, PHB depolymerase GO:0005576|GO:0016787 SHXM_RS04395 8b4c6efc43c95a9b70d94aa7aa8241b0 327 SUPERFAMILY SSF53474 47 125 3.55E-12 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 TIGRFAM TIGR03699 menaquin_MqnC: dehypoxanthine futalosine cyclase 19 360 2.7E-138 T 17-03-2017 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 Pfam PF04055 Radical SAM superfamily 65 238 1.2E-16 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 PIRSF PIRSF004762 1 373 3.2E-107 T 17-03-2017 IPR005244 FO synthase, subunit 2-like GO:0016765|GO:0051188|GO:0051539 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 SMART SM00729 54 281 0.0085 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 SUPERFAMILY SSF102114 18 352 1.57E-51 T 17-03-2017 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 TIGRFAM TIGR00423 TIGR00423: radical SAM domain protein, CofH subfamily 57 360 5.2E-104 T 17-03-2017 IPR020050 FO synthase, subunit 2 GO:0016765 KEGG: 00680+2.5.1.77|MetaCyc: PWY-5198 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 Hamap MF_00992 Cyclic dehypoxanthine futalosine synthase [mqnC]. 17 363 50.51 T 17-03-2017 IPR022431 Cyclic dehypoxanthine futalosine synthase GO:0009234 KEGG: 00130+1.21.98.1|MetaCyc: PWY-7371|MetaCyc: PWY-7374 SHXM_RS30720 04615f1045d126bd3f39a66365ead5e3 399 Gene3D G3DSA:3.20.20.70 19 353 5.0E-64 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 SUPERFAMILY SSF51338 2 66 1.17E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 Gene3D G3DSA:3.20.20.140 59 333 1.9E-71 T 17-03-2017 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 SUPERFAMILY SSF51556 57 350 6.24E-69 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 SUPERFAMILY SSF51338 332 390 9.93E-12 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 Gene3D G3DSA:2.30.40.10 2 58 5.0E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 Gene3D G3DSA:2.30.40.10 362 389 5.0E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 Gene3D G3DSA:2.30.40.10 334 361 8.9E-7 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS10535 c9465875570ea8f778f2439e3e703f3b 390 Pfam PF01979 Amidohydrolase family 53 385 1.0E-38 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS38495 fa1c78658d033bbc72c9c9dc9cec90a9 135 TIGRFAM TIGR00357 TIGR00357: methionine-R-sulfoxide reductase 8 134 3.6E-49 T 17-03-2017 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS38495 fa1c78658d033bbc72c9c9dc9cec90a9 135 SUPERFAMILY SSF51316 6 134 1.88E-55 T 17-03-2017 IPR011057 Mss4-like SHXM_RS38495 fa1c78658d033bbc72c9c9dc9cec90a9 135 Gene3D G3DSA:2.170.150.20 3 134 7.2E-61 T 17-03-2017 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS38495 fa1c78658d033bbc72c9c9dc9cec90a9 135 Pfam PF01641 SelR domain 11 131 1.3E-53 T 17-03-2017 IPR002579 Peptide methionine sulphoxide reductase MrsB GO:0033743|GO:0055114 Reactome: R-HSA-5676934 SHXM_RS08450 5b5158f0d7a0ce0838312aaf45199756 240 Hamap MF_01384 Urease accessory protein UreD [ureD]. 5 240 19.568 T 17-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 SHXM_RS08450 5b5158f0d7a0ce0838312aaf45199756 240 Pfam PF01774 UreD urease accessory protein 38 198 1.1E-28 T 17-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 SUPERFAMILY SSF53474 23 277 1.26E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 Pfam PF00561 alpha/beta hydrolase fold 33 131 5.3E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 Pfam PF08386 TAP-like protein 211 278 3.4E-5 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00111 Alpha/beta hydrolase fold signature 58 73 6.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00111 Alpha/beta hydrolase fold signature 222 236 6.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00111 Alpha/beta hydrolase fold signature 102 115 6.3E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 Gene3D G3DSA:3.40.50.1820 22 279 1.4E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00412 Epoxide hydrolase signature 253 275 1.8E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00412 Epoxide hydrolase signature 102 115 1.8E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00412 Epoxide hydrolase signature 58 73 1.8E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS38420 bfbdd0ed02c80e19d50c445c430350ec 283 PRINTS PR00412 Epoxide hydrolase signature 220 236 1.8E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 Gene3D G3DSA:1.10.10.60 3 59 8.0E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 2.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 2.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 14 58 1.1E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 Gene3D G3DSA:1.10.357.10 60 196 2.5E-45 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 SUPERFAMILY SSF46689 2 86 7.28E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS28360 306f7c3d3a60876824b791b9155d10a0 197 SUPERFAMILY SSF48498 82 194 1.16E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS43440 3c574662832e614605a695ae1a12ab9c 390 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 355 366 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS43440 3c574662832e614605a695ae1a12ab9c 390 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 276 287 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS43440 3c574662832e614605a695ae1a12ab9c 390 Gene3D G3DSA:1.10.1060.10 269 295 2.2E-10 T 17-03-2017 SHXM_RS43440 3c574662832e614605a695ae1a12ab9c 390 Gene3D G3DSA:1.10.1060.10 329 384 2.2E-10 T 17-03-2017 SHXM_RS43440 3c574662832e614605a695ae1a12ab9c 390 SUPERFAMILY SSF46548 267 383 4.19E-15 T 17-03-2017 IPR009051 Alpha-helical ferredoxin GO:0051536 SHXM_RS43440 3c574662832e614605a695ae1a12ab9c 390 Pfam PF17179 4Fe-4S dicluster domain 275 369 2.5E-33 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 313 442 5.1E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 Gene3D G3DSA:2.60.40.10 252 290 9.2E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 Gene3D G3DSA:1.10.3720.10 312 448 6.7E-71 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 Gene3D G3DSA:1.10.3720.10 35 161 6.7E-71 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 SUPERFAMILY SSF161098 309 445 4.51E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 SUPERFAMILY SSF161098 78 168 4.51E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23890 46a83b29bf533ee99c0eb0dab9113523 457 SUPERFAMILY SSF160964 33 86 6.93E-7 T 17-03-2017 SHXM_RS34075 51a054d51c547c83ea892697f2a126bf 94 TIGRFAM TIGR03544 DivI1A_domain: DivIVA domain 49 79 1.1E-6 T 17-03-2017 IPR019933 DivIVA domain SHXM_RS21350 1f44b80e3cd61edd066088e6caa8f38d 311 Pfam PF04794 YdjC-like protein 29 276 5.5E-50 T 17-03-2017 IPR006879 Chitooligosaccharide deacetylase ChbG-like SHXM_RS21350 1f44b80e3cd61edd066088e6caa8f38d 311 Gene3D G3DSA:3.20.20.370 26 288 1.0E-62 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS21350 1f44b80e3cd61edd066088e6caa8f38d 311 SUPERFAMILY SSF88713 27 287 1.07E-56 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 Pfam PF01494 FAD binding domain 7 358 9.3E-21 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 SUPERFAMILY SSF51905 282 374 3.8E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 SUPERFAMILY SSF51905 6 176 3.8E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 297 312 1.3E-19 T 17-03-2017 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 312 328 1.3E-19 T 17-03-2017 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 6 28 1.3E-19 T 17-03-2017 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 155 170 1.3E-19 T 17-03-2017 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 Gene3D G3DSA:3.50.50.60 6 181 3.3E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14485 712bd34b2b088840306bb97b44a9cad9 390 Gene3D G3DSA:3.50.50.60 283 362 3.3E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11750 b588ddf6a2bd782a3fce58a15ad410cb 220 SUPERFAMILY SSF52499 11 205 4.19E-47 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS11750 b588ddf6a2bd782a3fce58a15ad410cb 220 Pfam PF00857 Isochorismatase family 18 168 1.4E-27 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS11750 b588ddf6a2bd782a3fce58a15ad410cb 220 Gene3D G3DSA:3.40.50.850 12 199 7.7E-42 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS00705 a2131553e05f7604c43370932c4dfd73 541 SUPERFAMILY SSF52540 247 445 1.24E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00705 a2131553e05f7604c43370932c4dfd73 541 Gene3D G3DSA:3.40.50.300 247 445 1.1E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS47425 0ce7140b96fe3b4d221c861cd16d0b3b 130 Pfam PF01638 HxlR-like helix-turn-helix 30 116 5.3E-25 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS47425 0ce7140b96fe3b4d221c861cd16d0b3b 130 Gene3D G3DSA:1.10.10.10 16 127 3.5E-40 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47425 0ce7140b96fe3b4d221c861cd16d0b3b 130 SUPERFAMILY SSF46785 18 125 4.77E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31695 c2065bfa9fde00b713cb8731e7ab1f63 290 SUPERFAMILY SSF161098 25 287 3.08E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31695 c2065bfa9fde00b713cb8731e7ab1f63 290 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 103 279 3.6E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31695 c2065bfa9fde00b713cb8731e7ab1f63 290 Gene3D G3DSA:1.10.3720.10 18 278 5.0E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 Gene3D G3DSA:3.40.190.80 156 260 1.6E-28 T 17-03-2017 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 85 98 - T 17-03-2017 IPR020583 Inositol monophosphatase, metal-binding site SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 SUPERFAMILY SSF56655 6 259 1.07E-73 T 17-03-2017 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 Gene3D G3DSA:3.30.540.10 6 155 7.5E-48 T 17-03-2017 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 Pfam PF00459 Inositol monophosphatase family 6 228 2.2E-56 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 211 235 1.3E-42 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 85 101 1.3E-42 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 43 63 1.3E-42 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 134 157 1.3E-42 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 65 81 1.3E-42 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS37595 7747d0641b60ac97bfed511d0d115f91 266 PRINTS PR00377 Inositol monophosphatase superfamily signature 180 201 1.3E-42 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS24305 3601028b6c25593a95b48061d3229d8a 399 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 12 370 2.0E-116 T 17-03-2017 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533|Reactome: R-HSA-2142691|Reactome: R-HSA-5423646 SHXM_RS24305 3601028b6c25593a95b48061d3229d8a 399 SUPERFAMILY SSF51556 293 380 3.67E-104 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS24305 3601028b6c25593a95b48061d3229d8a 399 SUPERFAMILY SSF51556 6 253 3.67E-104 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS24305 3601028b6c25593a95b48061d3229d8a 399 Gene3D G3DSA:3.20.20.140 4 386 1.9E-148 T 17-03-2017 SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 SUPERFAMILY SSF54862 3 91 9.12E-22 T 17-03-2017 SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 PRINTS PR00354 7Fe ferredoxin signature 19 29 6.0E-18 T 17-03-2017 IPR000813 7Fe ferredoxin GO:0009055 SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 PRINTS PR00354 7Fe ferredoxin signature 35 52 6.0E-18 T 17-03-2017 IPR000813 7Fe ferredoxin GO:0009055 SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 PRINTS PR00354 7Fe ferredoxin signature 9 19 6.0E-18 T 17-03-2017 IPR000813 7Fe ferredoxin GO:0009055 SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature. 40 51 - T 17-03-2017 IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 Pfam PF00037 4Fe-4S binding domain 34 55 1.3E-8 T 17-03-2017 IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain SHXM_RS34035 e3ea5e10eef67fb8a1c936388774b3ad 108 Gene3D G3DSA:3.30.70.20 3 76 1.1E-19 T 17-03-2017 SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 SUPERFAMILY SSF51735 119 268 1.9E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 147 168 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 SUPERFAMILY SSF50129 1 152 6.09E-38 T 17-03-2017 IPR011032 GroES-like SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 Pfam PF00107 Zinc-binding dehydrogenase 158 241 1.3E-19 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 SMART SM00829 10 305 4.6E-27 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 Gene3D G3DSA:3.90.180.10 1 152 4.3E-47 T 17-03-2017 IPR011032 GroES-like SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 91 2.7E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS16330 4c4fd38c24a261206a2bd5fc3d385d3e 308 Gene3D G3DSA:3.40.50.720 153 242 1.3E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 1.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 1.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 1.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 91 1.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 1.3E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 138 166 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 182 1.7E-4 T 17-03-2017 SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 SUPERFAMILY SSF51735 5 246 1.16E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 Gene3D G3DSA:3.40.50.720 1 245 1.5E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25005 b77e3a8c10a1110f68708cea26fa9287 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 245 4.6E-59 T 17-03-2017 SHXM_RS49445 672f96d3c6c54e09ed8751d362f25ab2 378 Pfam PF00266 Aminotransferase class-V 51 367 2.8E-36 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS49445 672f96d3c6c54e09ed8751d362f25ab2 378 SUPERFAMILY SSF53383 1 376 1.49E-66 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS49445 672f96d3c6c54e09ed8751d362f25ab2 378 Gene3D G3DSA:3.90.1150.10 272 373 1.1E-8 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS49445 672f96d3c6c54e09ed8751d362f25ab2 378 Gene3D G3DSA:3.40.640.10 42 271 8.3E-53 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS40835 3447c04a83dc362c5a9d8588b15a6a6f 138 Gene3D G3DSA:3.40.50.720 2 82 1.0E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40835 3447c04a83dc362c5a9d8588b15a6a6f 138 Pfam PF00106 short chain dehydrogenase 8 82 3.6E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40835 3447c04a83dc362c5a9d8588b15a6a6f 138 SUPERFAMILY SSF51735 3 83 1.11E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS26820 a6746f7fb4aee5f738b58cb4fbd8d4f3 280 SMART SM00943 11 187 1.4E-30 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS20085 2eb15e6d6ea64e9e4d162c5c805a6932 222 Gene3D G3DSA:3.40.109.10 2 91 5.6E-46 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS20085 2eb15e6d6ea64e9e4d162c5c805a6932 222 Gene3D G3DSA:3.40.109.10 123 219 5.6E-46 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS20085 2eb15e6d6ea64e9e4d162c5c805a6932 222 Pfam PF00881 Nitroreductase family 8 197 4.8E-31 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS20085 2eb15e6d6ea64e9e4d162c5c805a6932 222 SUPERFAMILY SSF55469 2 84 2.62E-44 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS20085 2eb15e6d6ea64e9e4d162c5c805a6932 222 SUPERFAMILY SSF55469 123 218 2.62E-44 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 SMART SM00739 235 262 3.5E-4 T 17-03-2017 IPR005824 KOW SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 Gene3D G3DSA:2.30.30.30 234 288 2.0E-25 T 17-03-2017 IPR014722 Ribosomal protein L2 domain 2 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 PRINTS PR00338 Transcription termination factor NUSG signature 265 281 4.2E-18 T 17-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 PRINTS PR00338 Transcription termination factor NUSG signature 154 166 4.2E-18 T 17-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 PRINTS PR00338 Transcription termination factor NUSG signature 247 262 4.2E-18 T 17-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 SUPERFAMILY SSF50104 234 288 4.91E-15 T 17-03-2017 IPR008991 Translation protein SH3-like domain SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 SMART SM00738 99 207 2.7E-48 T 17-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 TIGRFAM TIGR00922 nusG: transcription termination/antitermination factor NusG 102 288 1.2E-53 T 17-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 SUPERFAMILY SSF82679 101 207 4.19E-34 T 17-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 ProSitePatterns PS01014 Transcription termination factor nusG signature. 272 281 - T 17-03-2017 IPR015869 Transcription antitermination protein, NusG, bacteria, conserved site SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 Hamap MF_00948 Transcription termination/antitermination protein NusG [nusG]. 99 289 22.578 T 17-03-2017 IPR001062 Transcription antitermination protein, NusG GO:0032784 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 Gene3D G3DSA:3.30.70.940 101 209 8.0E-41 T 17-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 SHXM_RS31080 61f1f0e522b307934bcfde8d6831d259 289 Pfam PF02357 Transcription termination factor nusG 101 203 4.2E-22 T 17-03-2017 IPR006645 NusG, N-terminal GO:0006355 Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167200|Reactome: R-HSA-167238|Reactome: R-HSA-167242|Reactome: R-HSA-167243|Reactome: R-HSA-167246|Reactome: R-HSA-167287|Reactome: R-HSA-167290|Reactome: R-HSA-674695|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-75955|Reactome: R-HSA-77075 SHXM_RS48595 a98269d8d5cfc82e2ca33b8b857a41ef 141 SUPERFAMILY SSF50249 6 126 6.17E-37 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS48595 a98269d8d5cfc82e2ca33b8b857a41ef 141 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 20 56 1.1E-15 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS48595 a98269d8d5cfc82e2ca33b8b857a41ef 141 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 57 122 2.8E-23 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS01030 216a05a6eba2b96b1bdae5f17da9169e 353 Gene3D G3DSA:3.40.50.720 6 262 4.4E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01030 216a05a6eba2b96b1bdae5f17da9169e 353 SUPERFAMILY SSF51735 7 266 1.57E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01030 216a05a6eba2b96b1bdae5f17da9169e 353 Pfam PF01370 NAD dependent epimerase/dehydratase family 7 132 4.1E-11 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS22990 7e0b639cb78f32bcc51d00ffe0a9335c 249 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 10 105 1.8E-22 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS22990 7e0b639cb78f32bcc51d00ffe0a9335c 249 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 31 211 5.8E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22990 7e0b639cb78f32bcc51d00ffe0a9335c 249 SUPERFAMILY SSF161098 8 196 4.58E-40 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22990 7e0b639cb78f32bcc51d00ffe0a9335c 249 TIGRFAM TIGR03004 ectoine_ehuC: ectoine/hydroxyectoine ABC transporter, permease protein EhuC 10 214 8.8E-73 T 17-03-2017 IPR014342 Ectoine/hydroxyectoine ABC transporter, permease protein EhuC SHXM_RS22990 7e0b639cb78f32bcc51d00ffe0a9335c 249 Gene3D G3DSA:1.10.3720.10 7 211 1.5E-43 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 Pfam PF13378 Enolase C-terminal domain-like 128 354 1.5E-55 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 SMART SM00922 125 230 6.9E-18 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 SUPERFAMILY SSF51604 95 358 5.09E-68 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 16 107 1.4E-21 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 82 107 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 Gene3D G3DSA:3.20.20.120 115 348 6.5E-74 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 SUPERFAMILY SSF54826 1 112 4.77E-30 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS38015 0718b0872c107a226297d3d089497cf4 381 Gene3D G3DSA:3.30.390.10 2 114 4.0E-43 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS27920 dfd0b12f6dadcc32881b2763e90b8547 462 Gene3D G3DSA:3.40.710.10 30 342 2.6E-73 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS27920 dfd0b12f6dadcc32881b2763e90b8547 462 Pfam PF00144 Beta-lactamase 28 340 9.7E-59 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS27920 dfd0b12f6dadcc32881b2763e90b8547 462 SUPERFAMILY SSF56601 29 326 8.12E-71 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 Gene3D G3DSA:3.40.630.10 12 188 2.6E-49 T 17-03-2017 SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 Gene3D G3DSA:3.40.630.10 342 402 2.6E-49 T 17-03-2017 SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 Gene3D G3DSA:3.30.70.360 189 287 7.5E-9 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 SUPERFAMILY SSF55031 180 286 4.19E-6 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 Pfam PF01546 Peptidase family M20/M25/M40 75 397 3.5E-28 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 Pfam PF07687 Peptidase dimerisation domain 178 288 2.0E-5 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 SUPERFAMILY SSF53187 8 188 9.14E-50 T 17-03-2017 SHXM_RS48695 6c2956c373970f8edb2a0fa5a28536e8 416 SUPERFAMILY SSF53187 321 401 9.14E-50 T 17-03-2017 SHXM_RS48485 9c25685e0f48049a25b468e84d7a0e45 158 Gene3D G3DSA:1.10.10.10 17 150 2.0E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48485 9c25685e0f48049a25b468e84d7a0e45 158 SMART SM00347 33 133 6.3E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS48485 9c25685e0f48049a25b468e84d7a0e45 158 PRINTS PR00598 Bacterial regulatory protein MarR family signature 93 109 6.9E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS48485 9c25685e0f48049a25b468e84d7a0e45 158 PRINTS PR00598 Bacterial regulatory protein MarR family signature 74 89 6.9E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS48485 9c25685e0f48049a25b468e84d7a0e45 158 SUPERFAMILY SSF46785 19 149 7.44E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48485 9c25685e0f48049a25b468e84d7a0e45 158 Pfam PF01047 MarR family 43 97 7.3E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS24755 29df9a954d1cb2d0a0704ed871d8cffb 477 Gene3D G3DSA:3.40.309.10 270 455 1.1E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS24755 29df9a954d1cb2d0a0704ed871d8cffb 477 Pfam PF00171 Aldehyde dehydrogenase family 36 476 4.9E-165 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS24755 29df9a954d1cb2d0a0704ed871d8cffb 477 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 256 263 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS24755 29df9a954d1cb2d0a0704ed871d8cffb 477 SUPERFAMILY SSF53720 18 476 1.57E-165 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS24755 29df9a954d1cb2d0a0704ed871d8cffb 477 Gene3D G3DSA:3.40.605.10 21 269 3.8E-98 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 Pfam PF00069 Protein kinase domain 19 275 3.1E-44 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 Gene3D G3DSA:3.30.200.20 11 88 1.2E-21 T 17-03-2017 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 25 48 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 142 154 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 SMART SM00220 19 278 2.6E-53 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 Gene3D G3DSA:1.10.510.10 89 281 1.2E-43 T 17-03-2017 SHXM_RS31620 223b4843dfb224f92d590f4ebc4974e3 673 SUPERFAMILY SSF56112 16 299 9.17E-65 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS48230 3cbd59b0a5d681362691eb28ec414e16 425 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 114 364 3.6E-29 T 17-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 SHXM_RS48230 3cbd59b0a5d681362691eb28ec414e16 425 Gene3D G3DSA:3.60.130.10 84 366 3.0E-38 T 17-03-2017 SHXM_RS48230 3cbd59b0a5d681362691eb28ec414e16 425 SUPERFAMILY SSF51197 71 372 3.07E-48 T 17-03-2017 SHXM_RS15365 1161ec0a8b81a3fdbc2d0e447566a815 212 SUPERFAMILY SSF50475 58 208 2.45E-38 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS15365 1161ec0a8b81a3fdbc2d0e447566a815 212 SMART SM00903 65 208 2.3E-41 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS15365 1161ec0a8b81a3fdbc2d0e447566a815 212 Pfam PF01613 Flavin reductase like domain 66 209 4.2E-30 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS15365 1161ec0a8b81a3fdbc2d0e447566a815 212 Gene3D G3DSA:2.30.110.10 57 207 5.2E-46 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18235 fe21bbd3cfe22dac192f11278f8b83c5 128 SUPERFAMILY SSF54593 1 124 1.19E-22 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS18235 fe21bbd3cfe22dac192f11278f8b83c5 128 Gene3D G3DSA:3.10.180.10 2 124 3.6E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS18235 fe21bbd3cfe22dac192f11278f8b83c5 128 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 10 120 1.8E-7 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 Gene3D G3DSA:3.30.390.50 224 325 1.1E-34 T 17-03-2017 SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 3 219 1.5E-48 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 Gene3D G3DSA:3.30.465.10 156 219 8.7E-33 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 Gene3D G3DSA:3.30.465.10 55 112 8.7E-33 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 SUPERFAMILY SSF55447 223 324 1.7E-28 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 SMART SM01092 225 323 1.3E-29 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 SUPERFAMILY SSF56176 1 219 1.31E-58 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 Gene3D G3DSA:3.30.43.10 1 50 5.8E-19 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS03035 2cf48592d695e860a3459fa603bd554a 327 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 226 322 2.9E-16 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 SUPERFAMILY SSF103473 255 426 4.71E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 SUPERFAMILY SSF103473 486 520 4.71E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 SUPERFAMILY SSF103473 13 205 4.71E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 Gene3D G3DSA:1.20.1250.20 17 202 6.9E-33 T 17-03-2017 SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 23 489 6.2E-73 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 Pfam PF07690 Major Facilitator Superfamily 26 416 4.4E-48 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 Gene3D G3DSA:1.20.1250.20 487 523 6.8E-23 T 17-03-2017 SHXM_RS41515 e5c8f29e90f3dcdfa5bedc3316945b09 536 Gene3D G3DSA:1.20.1250.20 272 426 6.8E-23 T 17-03-2017 SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 10 133 5.9E-23 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 Gene3D G3DSA:3.30.360.10 345 388 2.1E-49 T 17-03-2017 SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 Gene3D G3DSA:3.30.360.10 158 297 2.1E-49 T 17-03-2017 SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 SUPERFAMILY SSF55347 144 313 1.28E-35 T 17-03-2017 SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 SUPERFAMILY SSF51735 6 170 7.56E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 150 273 9.0E-11 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS14195 5572f856a98c890f8cc1167fd133aeb2 396 Gene3D G3DSA:3.40.50.720 5 157 2.7E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 PIRSF PIRSF001553 22 317 1.6E-70 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 Pfam PF13607 Succinyl-CoA ligase like flavodoxin domain 170 306 7.3E-8 T 17-03-2017 IPR032875 Succinyl-CoA synthetase-like, flavodoxin domain SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 SMART SM00881 25 121 4.5E-14 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 Gene3D G3DSA:3.40.50.261 141 313 1.4E-31 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 SUPERFAMILY SSF51735 32 143 9.62E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 Pfam PF02629 CoA binding domain 33 119 1.9E-19 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 PRINTS PR01798 Succinyl-CoA synthase signature 269 286 1.9E-5 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 PRINTS PR01798 Succinyl-CoA synthase signature 103 120 1.9E-5 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 PRINTS PR01798 Succinyl-CoA synthase signature 202 220 1.9E-5 T 17-03-2017 IPR005810 Succinyl-CoA ligase, alpha subunit GO:0003824|GO:0008152 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 SUPERFAMILY SSF52210 144 309 8.24E-24 T 17-03-2017 IPR016102 Succinyl-CoA synthetase-like KEGG: 00020+6.2.1.5|KEGG: 00640+6.2.1.5|KEGG: 00660+6.2.1.5|KEGG: 00720+6.2.1.5|MetaCyc: PWY-5392|MetaCyc: PWY-5537|MetaCyc: PWY-5538|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7384 SHXM_RS48625 7f68f62be9866d119760c0c62e434917 321 Gene3D G3DSA:3.40.50.720 32 140 1.2E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19890 b6f10d93f48f7994ff5711ba528639a0 136 SUPERFAMILY SSF102462 2 135 6.02E-45 T 17-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 SHXM_RS19890 b6f10d93f48f7994ff5711ba528639a0 136 Gene3D G3DSA:3.40.1490.10 2 135 4.7E-57 T 17-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 SHXM_RS19890 b6f10d93f48f7994ff5711ba528639a0 136 Pfam PF09391 Protein of unknown function (DUF2000) 5 135 1.4E-41 T 17-03-2017 IPR018988 Protein of unknown function DUF2000 SHXM_RS20900 195fd4d2a1a428da4ffc46564b0bf829 504 Pfam PF13520 Amino acid permease 24 447 4.5E-51 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS20900 195fd4d2a1a428da4ffc46564b0bf829 504 PIRSF PIRSF006060 3 491 7.1E-83 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 24 254 5.9E-54 T 17-03-2017 SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 163 182 1.3E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 184 201 1.3E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 1.3E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 1.3E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 218 238 1.3E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 16 198 2.0E-4 T 17-03-2017 SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 SUPERFAMILY SSF51735 16 254 4.81E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05595 e9f980e7356d0affba3843aee7cd6234 255 Gene3D G3DSA:3.40.50.720 15 254 8.5E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 Gene3D G3DSA:2.60.120.260 578 724 1.3E-31 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 Pfam PF12708 Pectate lyase superfamily protein 195 412 1.4E-14 T 17-03-2017 IPR024535 Pectate lyase superfamily protein SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SUPERFAMILY SSF51126 179 510 6.73E-39 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 Pfam PF00754 F5/8 type C domain 596 720 3.7E-17 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 374 397 1900.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 470 492 4000.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 323 345 5.1 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 398 422 9.6 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 433 464 4200.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 300 321 8700.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SMART SM00710 500 520 5500.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 Gene3D G3DSA:2.160.20.10 177 545 2.7E-39 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS05445 bd431a8f4137e4b6292f39554d3d1d7b 727 SUPERFAMILY SSF49785 586 724 4.11E-23 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 Gene3D G3DSA:3.40.50.970 25 197 8.6E-53 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 SMART SM00861 21 186 4.4E-44 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 Pfam PF02779 Transketolase, pyrimidine binding domain 25 181 2.3E-37 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 SUPERFAMILY SSF52922 192 326 8.9E-33 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 Gene3D G3DSA:3.40.50.920 198 326 7.2E-35 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 Pfam PF02780 Transketolase, C-terminal domain 197 318 1.3E-29 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS01075 745b86086d238fad7dd48d6cd0959338 331 SUPERFAMILY SSF52518 25 187 1.33E-48 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS22465 11044e8039bfa5b9f08d127a17b4d808 265 Pfam PF01261 Xylose isomerase-like TIM barrel 20 212 1.0E-32 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS22465 11044e8039bfa5b9f08d127a17b4d808 265 Gene3D G3DSA:3.20.20.150 1 262 2.8E-61 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS22465 11044e8039bfa5b9f08d127a17b4d808 265 SUPERFAMILY SSF51658 1 264 6.55E-48 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 SUPERFAMILY SSF88659 193 263 1.78E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 Pfam PF08281 Sigma-70, region 4 208 259 9.0E-14 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 104 261 1.6E-29 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 Gene3D G3DSA:1.10.10.10 202 264 7.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 SUPERFAMILY SSF88946 87 195 6.87E-27 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 TIGRFAM TIGR02952 Sig70_famx2: RNA polymerase sigma-70 factor, TIGR02952 family 94 263 6.6E-78 T 17-03-2017 IPR014298 RNA polymerase sigma-X type SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 Gene3D G3DSA:1.10.1740.10 93 201 9.2E-29 T 17-03-2017 SHXM_RS30440 5ce6d24b6ce24f984163fc83cc09fa91 268 Pfam PF04542 Sigma-70 region 2 109 176 1.0E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS31990 d8a9636b5aa023f3f1ef85d3dafc7712 275 Gene3D G3DSA:3.40.50.720 3 208 1.8E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31990 d8a9636b5aa023f3f1ef85d3dafc7712 275 Pfam PF13460 NAD(P)H-binding 6 172 8.7E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31990 d8a9636b5aa023f3f1ef85d3dafc7712 275 SUPERFAMILY SSF51735 3 267 2.85E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19970 3d08a1022a966d93301b43829c831fd5 153 Gene3D G3DSA:3.40.630.30 7 138 1.6E-27 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19970 3d08a1022a966d93301b43829c831fd5 153 SUPERFAMILY SSF55729 9 150 1.36E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19970 3d08a1022a966d93301b43829c831fd5 153 Pfam PF00583 Acetyltransferase (GNAT) family 51 133 2.5E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 SUPERFAMILY SSF51604 201 446 1.31E-69 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 SUPERFAMILY SSF54826 19 156 9.09E-35 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 49 153 3.2E-7 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 Gene3D G3DSA:3.30.390.10 18 194 4.6E-81 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 SMART SM00922 216 312 1.4E-26 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 Pfam PF13378 Enolase C-terminal domain-like 219 431 4.9E-61 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 ProSitePatterns PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 262 293 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS16045 3f8d670059e5d5fb8a2689a52ea75e74 475 Gene3D G3DSA:3.20.20.120 199 442 4.0E-91 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 Gene3D G3DSA:3.20.20.140 160 374 1.8E-49 T 17-03-2017 SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 Gene3D G3DSA:3.20.20.140 406 477 1.8E-49 T 17-03-2017 SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 Gene3D G3DSA:2.30.40.10 484 526 4.6E-17 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 Gene3D G3DSA:2.30.40.10 99 159 4.6E-17 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 Pfam PF01979 Amidohydrolase family 154 508 2.5E-19 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 SUPERFAMILY SSF51556 157 479 2.43E-46 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 SUPERFAMILY SSF51338 101 158 5.45E-18 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS47830 1acf28068978c3b445059fd7c36e55b1 532 SUPERFAMILY SSF51338 484 525 5.45E-18 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS18570 39f02980666d1a8c35c029c01d23dc5f 453 Pfam PF01098 Cell cycle protein 64 413 5.0E-92 T 17-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SHXM_RS18570 39f02980666d1a8c35c029c01d23dc5f 453 TIGRFAM TIGR02614 ftsW: cell division protein FtsW 58 414 1.2E-111 T 17-03-2017 IPR013437 Cell division protein FtsW GO:0009252|GO:0016021|GO:0051301 SHXM_RS18570 39f02980666d1a8c35c029c01d23dc5f 453 ProSitePatterns PS00428 Cell cycle proteins ftsW / rodA / spoVE signature. 373 397 - T 17-03-2017 IPR018365 Cell cycle, FtsW / RodA / SpoVE, conserved site GO:0007049|GO:0016021 SHXM_RS08560 febf750d807faea85e13a9a0f541ec29 305 TIGRFAM TIGR03621 F420_MSMEG_2516: probable F420-dependent oxidoreductase, MSMEG_2516 family 5 302 1.9E-106 T 17-03-2017 IPR019923 Luciferase-like, F420-dependent oxidoreductase, MSMEG2516, predicted SHXM_RS08560 febf750d807faea85e13a9a0f541ec29 305 Pfam PF00296 Luciferase-like monooxygenase 17 213 1.6E-33 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS08560 febf750d807faea85e13a9a0f541ec29 305 SUPERFAMILY SSF51679 4 302 3.14E-50 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS08560 febf750d807faea85e13a9a0f541ec29 305 Gene3D G3DSA:3.20.20.30 3 300 2.4E-52 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS25055 b71469ae005e1dee52baef09a119388f 416 SUPERFAMILY SSF53474 137 191 1.03E-17 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25055 b71469ae005e1dee52baef09a119388f 416 SUPERFAMILY SSF53474 225 346 1.03E-17 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25055 b71469ae005e1dee52baef09a119388f 416 Gene3D G3DSA:3.40.50.1820 44 88 1.0E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25055 b71469ae005e1dee52baef09a119388f 416 Gene3D G3DSA:3.40.50.1820 141 187 1.0E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25055 b71469ae005e1dee52baef09a119388f 416 Gene3D G3DSA:3.40.50.1820 221 413 1.0E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25055 b71469ae005e1dee52baef09a119388f 416 Pfam PF03403 Platelet-activating factor acetylhydrolase, isoform II 46 189 5.0E-6 T 17-03-2017 IPR005065 Platelet-activating factor acetylhydrolase GO:0003847|GO:0016042 KEGG: 00565+3.1.1.47 SHXM_RS22030 2f8a916d98cff35ce4a9c889f28c5078 229 Gene3D G3DSA:3.40.50.80 110 226 2.7E-24 T 17-03-2017 SHXM_RS22030 2f8a916d98cff35ce4a9c889f28c5078 229 Gene3D G3DSA:2.40.30.10 14 106 8.7E-17 T 17-03-2017 SHXM_RS22030 2f8a916d98cff35ce4a9c889f28c5078 229 Pfam PF04954 Siderophore-interacting protein 114 224 5.7E-27 T 17-03-2017 IPR007037 Siderophore-interacting protein SHXM_RS22030 2f8a916d98cff35ce4a9c889f28c5078 229 SUPERFAMILY SSF63380 13 108 2.65E-11 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS22030 2f8a916d98cff35ce4a9c889f28c5078 229 Pfam PF08021 Siderophore-interacting FAD-binding domain 58 107 5.1E-6 T 17-03-2017 IPR013113 FAD-binding 9, siderophore-interacting SHXM_RS20750 d1262fb3a6eca791b1229c10fc086cb2 445 Gene3D G3DSA:3.40.190.10 166 365 2.0E-39 T 17-03-2017 SHXM_RS20750 d1262fb3a6eca791b1229c10fc086cb2 445 Pfam PF13416 Bacterial extracellular solute-binding protein 67 380 1.0E-37 T 17-03-2017 SHXM_RS20750 d1262fb3a6eca791b1229c10fc086cb2 445 SUPERFAMILY SSF53850 37 442 6.52E-72 T 17-03-2017 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 Gene3D G3DSA:3.40.50.720 210 371 8.1E-60 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 Pfam PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 203 446 5.3E-82 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 Gene3D G3DSA:3.40.192.10 68 188 1.1E-61 T 17-03-2017 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 ProSitePatterns PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 122 135 - T 17-03-2017 IPR033524 Leu/Phe/Val dehydrogenases active site Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 SMART SM00839 205 446 6.1E-82 T 17-03-2017 IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminal GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 PIRSF PIRSF000185 22 448 1.7E-117 T 17-03-2017 IPR014362 Glutamate dehydrogenase GO:0016639|GO:0055114 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 Gene3D G3DSA:1.10.285.10 5 67 2.1E-24 T 17-03-2017 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 Gene3D G3DSA:1.10.285.10 372 447 7.8E-21 T 17-03-2017 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 SUPERFAMILY SSF51735 203 447 8.54E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 Pfam PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 57 185 2.7E-49 T 17-03-2017 IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domain GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 SUPERFAMILY SSF53223 7 197 3.84E-75 T 17-03-2017 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 114 128 3.8E-30 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 371 382 3.8E-30 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 194 216 3.8E-30 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS41290 c6de573276f272bf0f43f56632fe187d 448 PRINTS PR00082 Glutamate/leucine/phenylalanine/valine dehydrogenase signature 236 256 3.8E-30 T 17-03-2017 IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenase GO:0006520|GO:0016491|GO:0055114 Reactome: R-HSA-70614 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 SUPERFAMILY SSF161098 83 265 4.45E-40 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 SUPERFAMILY SSF53850 335 595 1.29E-71 T 17-03-2017 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 272 4.1E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Gene3D G3DSA:3.40.190.100 423 538 2.9E-35 T 17-03-2017 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Gene3D G3DSA:3.40.190.100 695 818 5.2E-36 T 17-03-2017 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 339 587 1.8E-63 T 17-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 613 858 2.6E-58 T 17-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Gene3D G3DSA:3.40.190.10 539 595 1.3E-62 T 17-03-2017 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Gene3D G3DSA:3.40.190.10 611 691 6.9E-29 T 17-03-2017 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Gene3D G3DSA:3.40.190.10 335 419 1.3E-62 T 17-03-2017 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 Gene3D G3DSA:1.10.3720.10 79 261 3.6E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15820 5048fadf8632917360a22caca45403e7 872 SUPERFAMILY SSF53850 613 867 8.91E-67 T 17-03-2017 SHXM_RS26380 5d2e09de475a298ad3afa354d365ad3e 380 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 53 64 - T 17-03-2017 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS26380 5d2e09de475a298ad3afa354d365ad3e 380 SUPERFAMILY SSF56762 26 379 1.83E-102 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS26380 5d2e09de475a298ad3afa354d365ad3e 380 Gene3D G3DSA:1.10.645.10 13 368 3.4E-60 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS26380 5d2e09de475a298ad3afa354d365ad3e 380 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 131 380 7.8E-69 T 17-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS26380 5d2e09de475a298ad3afa354d365ad3e 380 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 1 380 40.722 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 Gene3D G3DSA:3.20.20.140 69 410 6.2E-102 T 17-03-2017 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 SUPERFAMILY SSF51338 370 433 1.18E-21 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 SUPERFAMILY SSF51338 6 53 1.18E-21 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 TIGRFAM TIGR00857 pyrC_multi: dihydroorotase, multifunctional complex type 20 425 7.9E-126 T 17-03-2017 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 SUPERFAMILY SSF51556 54 368 4.38E-99 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 Gene3D G3DSA:2.30.40.10 6 68 8.7E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 Hamap MF_00220_B Dihydroorotase [pyrC]. 6 428 42.466 T 17-03-2017 IPR004722 Dihydroorotase GO:0004151|GO:0006221|GO:0046872 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 ProSitePatterns PS00483 Dihydroorotase signature 2. 304 315 - T 17-03-2017 IPR002195 Dihydroorotase, conserved site GO:0016812 KEGG: 00240+3.5.2.3|MetaCyc: PWY-5686 SHXM_RS12370 0983e9826103c7a8f6c519dfeac041ec 436 Pfam PF01979 Amidohydrolase family 50 422 3.2E-17 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Gene3D G3DSA:2.40.50.140 286 369 1.2E-29 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SUPERFAMILY SSF50249 110 194 1.27E-14 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 232 253 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 57 71 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 310 329 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 146 163 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 175 195 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 105 124 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 129 145 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 349 367 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 PRINTS PR00681 Ribosomal protein S1 signature 39 57 4.3E-86 T 17-03-2017 IPR000110 Ribosomal protein S1 GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SMART SM00316 37 108 1.9E-16 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SMART SM00316 210 280 1.3E-27 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SMART SM00316 124 191 6.5E-11 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SMART SM00316 295 366 1.1E-26 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Pfam PF00575 S1 RNA binding domain 36 108 5.0E-15 T 17-03-2017 IPR003029 S1 domain GO:0003676 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Pfam PF00575 S1 RNA binding domain 124 191 1.1E-13 T 17-03-2017 IPR003029 S1 domain GO:0003676 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Pfam PF00575 S1 RNA binding domain 294 366 3.6E-23 T 17-03-2017 IPR003029 S1 domain GO:0003676 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Pfam PF00575 S1 RNA binding domain 209 280 9.6E-26 T 17-03-2017 IPR003029 S1 domain GO:0003676 SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SUPERFAMILY SSF50249 210 292 3.29E-27 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SUPERFAMILY SSF50249 280 368 4.79E-26 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Gene3D G3DSA:2.40.50.140 205 285 1.9E-30 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 SUPERFAMILY SSF50249 31 133 5.07E-22 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Gene3D G3DSA:2.40.50.140 30 109 9.4E-18 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18085 d960c6b9c333c43c13fe79a9c98defd9 503 Gene3D G3DSA:2.40.50.140 116 192 8.0E-16 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS23990 d907ba52417d77350bd4a687d251bf2e 874 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 361 617 2.1E-69 T 17-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 SHXM_RS23990 d907ba52417d77350bd4a687d251bf2e 874 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 651 768 2.7E-43 T 17-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 SHXM_RS23990 d907ba52417d77350bd4a687d251bf2e 874 Gene3D G3DSA:3.90.550.10 6 253 6.1E-47 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS23990 d907ba52417d77350bd4a687d251bf2e 874 SUPERFAMILY SSF53756 530 767 1.38E-6 T 17-03-2017 SHXM_RS23990 d907ba52417d77350bd4a687d251bf2e 874 Pfam PF00535 Glycosyl transferase family 2 9 126 3.5E-31 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS23990 d907ba52417d77350bd4a687d251bf2e 874 SUPERFAMILY SSF53448 6 246 4.57E-49 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS31920 7208d381504bc24890225f3de153247f 297 SMART SM00530 17 72 2.5E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS31920 7208d381504bc24890225f3de153247f 297 Pfam PF13560 Helix-turn-helix domain 13 74 5.7E-18 T 17-03-2017 SHXM_RS31920 7208d381504bc24890225f3de153247f 297 Gene3D G3DSA:1.10.260.40 8 74 2.3E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS31920 7208d381504bc24890225f3de153247f 297 SUPERFAMILY SSF47413 10 72 2.65E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 SUPERFAMILY SSF48008 82 216 1.8E-20 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 SMART SM00345 18 76 1.5E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 7.9E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 7.9E-6 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 76 1.1E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 SMART SM00895 86 209 9.0E-14 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 Gene3D G3DSA:1.20.120.530 79 220 2.9E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 SUPERFAMILY SSF46785 16 80 8.49E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 Gene3D G3DSA:1.10.10.10 16 77 1.0E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47305 79b3bb64213d2d973164c58fccd63a24 234 Pfam PF07729 FCD domain 86 208 1.9E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS45195 3d859712af350337d00f23757929174e 620 Pfam PF00005 ABC transporter 391 540 7.9E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45195 3d859712af350337d00f23757929174e 620 SUPERFAMILY SSF52540 347 608 1.78E-87 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45195 3d859712af350337d00f23757929174e 620 SMART SM00382 400 586 3.0E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45195 3d859712af350337d00f23757929174e 620 ProSitePatterns PS00211 ABC transporters family signature. 512 526 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS45195 3d859712af350337d00f23757929174e 620 Gene3D G3DSA:3.40.50.300 378 605 9.5E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45195 3d859712af350337d00f23757929174e 620 SUPERFAMILY SSF90123 17 344 7.32E-69 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS45195 3d859712af350337d00f23757929174e 620 Gene3D G3DSA:1.20.1560.10 23 344 2.5E-68 T 17-03-2017 SHXM_RS45195 3d859712af350337d00f23757929174e 620 Pfam PF00664 ABC transporter transmembrane region 37 309 5.9E-40 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS21385 304e8c3b4d50bef77a3c67eb3bb196db 308 SUPERFAMILY SSF56281 60 297 2.16E-33 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21385 304e8c3b4d50bef77a3c67eb3bb196db 308 Gene3D G3DSA:3.60.15.10 56 292 4.3E-21 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21385 304e8c3b4d50bef77a3c67eb3bb196db 308 SMART SM00849 63 259 1.6E-6 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21385 304e8c3b4d50bef77a3c67eb3bb196db 308 Pfam PF00753 Metallo-beta-lactamase superfamily 62 238 7.9E-9 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS16710 a01dda69d7c4be59131a7200e36619bf 361 SUPERFAMILY SSF51735 184 360 3.24E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16710 a01dda69d7c4be59131a7200e36619bf 361 SUPERFAMILY SSF51735 6 171 6.0E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16710 a01dda69d7c4be59131a7200e36619bf 361 Pfam PF08659 KR domain 185 361 1.8E-61 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16710 a01dda69d7c4be59131a7200e36619bf 361 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 185 361 5.2E-56 T 17-03-2017 SHXM_RS16710 a01dda69d7c4be59131a7200e36619bf 361 Gene3D G3DSA:3.40.50.720 185 351 1.7E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22745 eacec4d0f8ce1e7cc84c4a930187e59c 337 Pfam PF00535 Glycosyl transferase family 2 39 166 1.1E-35 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS22745 eacec4d0f8ce1e7cc84c4a930187e59c 337 Gene3D G3DSA:3.90.550.10 37 262 1.4E-58 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS22745 eacec4d0f8ce1e7cc84c4a930187e59c 337 SUPERFAMILY SSF53448 37 235 2.89E-57 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 Pfam PF00732 GMC oxidoreductase 4 299 6.8E-74 T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 ProSitePatterns PS00624 GMC oxidoreductases signature 2. 257 271 - T 17-03-2017 IPR000172 Glucose-methanol-choline oxidoreductase, N-terminal GO:0016614|GO:0050660|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 SUPERFAMILY SSF51905 3 286 8.74E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 SUPERFAMILY SSF51905 451 513 8.74E-70 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 SUPERFAMILY SSF54373 293 455 7.75E-41 T 17-03-2017 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 Pfam PF05199 GMC oxidoreductase 370 507 5.9E-35 T 17-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 Gene3D G3DSA:3.50.50.60 2 124 5.5E-103 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 Gene3D G3DSA:3.50.50.60 186 316 5.5E-103 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13620 303bec2cec10abb1330bfd80fbefa0c7 514 Gene3D G3DSA:3.50.50.60 448 513 5.5E-103 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 SUPERFAMILY SSF51735 4 229 8.18E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 Pfam PF00106 short chain dehydrogenase 4 189 3.8E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 Gene3D G3DSA:3.40.50.720 1 229 6.4E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 5.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 5.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 5.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42220 426075e83c894f708f2592a9e8af3cd7 229 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 5.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 Pfam PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases 15 182 1.3E-19 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 SUPERFAMILY SSF53790 8 197 6.8E-32 T 17-03-2017 IPR000878 Tetrapyrrole methylase GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 SUPERFAMILY SSF53335 255 388 2.41E-14 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 PIRSF PIRSF036428 1 415 1.4E-83 T 17-03-2017 IPR006365 Cobalamin (vitamin B12) biosynthesis CobL/Precorrin-6Y C(5,15)-methyltransferase GO:0008276|GO:0009236 KEGG: 00270+2.1.1.13|KEGG: 00450+2.1.1.13|KEGG: 00670+2.1.1.13|KEGG: 00860+2.1.1.132|MetaCyc: PWY-2201|MetaCyc: PWY-3841 SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 Gene3D G3DSA:3.30.950.10 104 197 1.7E-18 T 17-03-2017 IPR014776 Tetrapyrrole methylase, subdomain 2 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 TIGRFAM TIGR02467 CbiE: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit 11 196 2.4E-37 T 17-03-2017 IPR012818 Cobalamin (vitamin B12) biosynthesis CbiE, precorrin-6Y methyltransferase GO:0008276|GO:0009236 SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 Gene3D G3DSA:3.40.1010.10 4 103 2.7E-15 T 17-03-2017 IPR014777 Tetrapyrrole methylase, subdomain 1 GO:0008152|GO:0008168 Reactome: R-HSA-5358493 SHXM_RS12800 c784731eb99913aa369bdb33fcb7970c 417 Gene3D G3DSA:3.40.50.150 254 399 1.7E-14 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS15795 b069fb3343f1dfe57a6920892cb61bb4 316 Pfam PF12146 Serine aminopeptidase, S33 32 300 3.2E-49 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS15795 b069fb3343f1dfe57a6920892cb61bb4 316 SUPERFAMILY SSF53474 5 316 3.46E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS15795 b069fb3343f1dfe57a6920892cb61bb4 316 Gene3D G3DSA:3.40.50.1820 12 145 2.0E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS15795 b069fb3343f1dfe57a6920892cb61bb4 316 Gene3D G3DSA:3.40.50.1820 184 315 2.0E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 73 1.3E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 SMART SM00895 83 202 2.0E-15 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 SUPERFAMILY SSF48008 84 206 8.89E-24 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 SMART SM00345 15 73 3.2E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 Gene3D G3DSA:1.10.10.10 7 74 5.6E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 Pfam PF07729 FCD domain 84 201 1.3E-22 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 SUPERFAMILY SSF46785 10 97 1.05E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 Gene3D G3DSA:1.20.120.530 80 206 2.6E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 47 63 1.5E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17675 c90fa309af6fed4f1b20c253cc38d47d 222 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 33 47 1.5E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 Pfam PF00072 Response regulator receiver domain 5 114 5.7E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 SMART SM00862 156 231 4.3E-24 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 SUPERFAMILY SSF52172 4 126 7.26E-42 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 Gene3D G3DSA:3.40.50.2300 4 126 3.1E-41 T 17-03-2017 SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 Gene3D G3DSA:1.10.10.10 135 233 1.4E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 SMART SM00448 3 114 3.5E-42 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 SUPERFAMILY SSF46894 136 232 2.07E-27 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS07445 5a4c69c90ae45e4d106ab0ece93d975a 234 Pfam PF00486 Transcriptional regulatory protein, C terminal 156 231 1.0E-22 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS02570 a4e62026a15140f343a0fe9202638520 167 Pfam PF13302 Acetyltransferase (GNAT) domain 6 144 1.1E-20 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS02570 a4e62026a15140f343a0fe9202638520 167 SUPERFAMILY SSF55729 6 147 6.6E-26 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS02570 a4e62026a15140f343a0fe9202638520 167 Gene3D G3DSA:3.40.630.30 6 154 2.4E-28 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 SUPERFAMILY SSF53474 5 292 1.95E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 Pfam PF00561 alpha/beta hydrolase fold 28 280 1.6E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 Gene3D G3DSA:3.40.50.1820 5 292 2.0E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 PRINTS PR00412 Epoxide hydrolase signature 31 49 5.5E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 PRINTS PR00412 Epoxide hydrolase signature 51 66 5.5E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 PRINTS PR00412 Epoxide hydrolase signature 97 110 5.5E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS03370 b457a30362ca7ce5622dbaaff3c53b40 293 PRINTS PR00412 Epoxide hydrolase signature 268 290 5.5E-20 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:1.20.1580.10 512 629 2.3E-33 T 17-03-2017 SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:1.20.1580.10 253 323 6.9E-32 T 17-03-2017 SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:1.20.1580.10 93 151 6.9E-32 T 17-03-2017 SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:3.40.50.300 3 61 2.9E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:3.40.50.300 456 508 3.9E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:3.40.50.300 630 746 3.9E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:3.40.50.300 324 438 2.9E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 SUPERFAMILY SSF52540 457 719 1.78E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Gene3D G3DSA:1.10.8.280 152 249 5.0E-9 T 17-03-2017 SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 Pfam PF00005 ABC transporter 464 666 2.2E-9 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 SUPERFAMILY SSF52540 7 155 1.25E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03670 7b60e7575e97d4d61e61fe15b4efe9df 749 SUPERFAMILY SSF52540 288 415 1.25E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31750 04ae090704b98bbda60745d2193ba3f8 230 Gene3D G3DSA:2.30.110.10 31 230 2.0E-54 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS31750 04ae090704b98bbda60745d2193ba3f8 230 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 56 125 4.4E-19 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS31750 04ae090704b98bbda60745d2193ba3f8 230 Pfam PF10590 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region 187 230 6.2E-9 T 17-03-2017 IPR019576 Pyridoxine 5'-phosphate oxidase, dimerisation, C-terminal GO:0016638|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS31750 04ae090704b98bbda60745d2193ba3f8 230 PIRSF PIRSF000190 13 230 6.3E-50 T 17-03-2017 IPR000659 Pyridoxamine 5'-phosphate oxidase GO:0004733|GO:0008615|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS31750 04ae090704b98bbda60745d2193ba3f8 230 SUPERFAMILY SSF50475 25 230 2.55E-43 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS42825 83b6d8391ac94a7cdfb653d26bfe346b 91 Gene3D G3DSA:1.10.1200.10 13 85 1.8E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42825 83b6d8391ac94a7cdfb653d26bfe346b 91 SUPERFAMILY SSF47336 17 89 6.41E-13 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS42825 83b6d8391ac94a7cdfb653d26bfe346b 91 Pfam PF00550 Phosphopantetheine attachment site 14 82 2.5E-7 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 PRINTS PR00069 Aldo-keto reductase signature 151 168 2.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 PRINTS PR00069 Aldo-keto reductase signature 115 133 2.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 PRINTS PR00069 Aldo-keto reductase signature 50 74 2.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 PRINTS PR00069 Aldo-keto reductase signature 221 245 2.0E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 Gene3D G3DSA:3.20.20.100 12 287 1.8E-61 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 SUPERFAMILY SSF51430 11 287 1.23E-63 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS39335 57f1a5b4f1909427008f495edbdcf4df 289 Pfam PF00248 Aldo/keto reductase family 20 287 2.5E-44 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS20265 6c966292271c924c6d79c934c2d24535 458 SUPERFAMILY SSF55874 343 449 1.51E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20265 6c966292271c924c6d79c934c2d24535 458 Pfam PF07730 Histidine kinase 242 307 2.0E-19 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 SUPERFAMILY SSF51905 1 286 1.22E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 Gene3D G3DSA:3.50.50.60 193 280 2.3E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 229 251 2.8E-13 T 17-03-2017 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 130 148 2.8E-13 T 17-03-2017 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 6 25 2.8E-13 T 17-03-2017 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 253 2.7E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 126 150 7.2E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 239 257 7.2E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 5 27 7.2E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 94 102 7.2E-6 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 Gene3D G3DSA:3.50.50.60 3 96 7.9E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06510 4f1872b23111fff0bb20b82b46c309bb 360 Gene3D G3DSA:3.50.50.60 97 192 1.5E-10 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11470 c27c26a767add1dc29eddf5d573e8107 405 Gene3D G3DSA:1.20.1250.20 24 202 5.8E-26 T 17-03-2017 SHXM_RS11470 c27c26a767add1dc29eddf5d573e8107 405 SUPERFAMILY SSF103473 12 401 4.32E-58 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11470 c27c26a767add1dc29eddf5d573e8107 405 Pfam PF07690 Major Facilitator Superfamily 31 359 1.5E-32 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS11470 c27c26a767add1dc29eddf5d573e8107 405 Gene3D G3DSA:1.20.1250.20 219 398 1.0E-12 T 17-03-2017 SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 Pfam PF00271 Helicase conserved C-terminal domain 264 362 7.4E-25 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 Gene3D G3DSA:3.40.50.300 24 236 1.9E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 SMART SM00487 47 247 3.7E-52 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 Pfam PF00270 DEAD/DEAH box helicase 52 220 5.1E-45 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 Gene3D G3DSA:3.40.50.300 237 387 1.3E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 SUPERFAMILY SSF52540 99 380 5.55E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39530 29c9667c5c5790e6b2cd0ac40c167157 477 SMART SM00490 281 362 6.4E-32 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS49770 198ec3b4de43e7df020dce1a50525652 510 SUPERFAMILY SSF103473 186 438 4.58E-26 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49770 198ec3b4de43e7df020dce1a50525652 510 Pfam PF07690 Major Facilitator Superfamily 2 386 2.3E-44 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS49770 198ec3b4de43e7df020dce1a50525652 510 SUPERFAMILY SSF103473 2 176 2.88E-39 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49770 198ec3b4de43e7df020dce1a50525652 510 Gene3D G3DSA:1.20.1250.20 2 180 5.5E-30 T 17-03-2017 SHXM_RS49770 198ec3b4de43e7df020dce1a50525652 510 Gene3D G3DSA:1.20.1250.20 243 444 2.2E-18 T 17-03-2017 SHXM_RS48125 ff8048ae5942dfeaf9ed30881138fbdb 260 Gene3D G3DSA:3.90.1200.10 29 199 7.2E-12 T 17-03-2017 SHXM_RS48125 ff8048ae5942dfeaf9ed30881138fbdb 260 SUPERFAMILY SSF56112 25 195 2.77E-17 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS48125 ff8048ae5942dfeaf9ed30881138fbdb 260 Pfam PF01636 Phosphotransferase enzyme family 120 191 6.3E-8 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 TIGRFAM TIGR00119 acolac_sm: acetolactate synthase, small subunit 3 158 1.3E-60 T 17-03-2017 IPR004789 Acetolactate synthase, small subunit GO:0003984|GO:0009082 KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 SUPERFAMILY SSF55021 3 75 3.49E-22 T 17-03-2017 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 Pfam PF10369 Small subunit of acetolactate synthase 85 158 1.6E-28 T 17-03-2017 IPR019455 Acetolactate synthase, small subunit, C-terminal KEGG: 00290+2.2.1.6|KEGG: 00650+2.2.1.6|KEGG: 00660+2.2.1.6|KEGG: 00770+2.2.1.6|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-5938|MetaCyc: PWY-5939|MetaCyc: PWY-6389|MetaCyc: PWY-7111 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 Gene3D G3DSA:3.30.70.260 1 79 7.7E-34 T 17-03-2017 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 Gene3D G3DSA:3.30.70.1150 84 163 7.0E-31 T 17-03-2017 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 SUPERFAMILY SSF55021 80 161 4.2E-26 T 17-03-2017 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 Pfam PF01842 ACT domain 4 69 3.1E-16 T 17-03-2017 IPR002912 ACT domain GO:0008152|GO:0016597 SHXM_RS36160 ca5630f629a4f8b8991ef3e12a737e4d 174 ProDom PD002844 SMALL SUBUNIT ACETOLACTATE SYNTHASE SYNTHASE TRANSFERASE ACID BIOSYNTHESIS III LYASE 3 77 3.0E-34 T 17-03-2017 SHXM_RS08240 20ec7a34706d33c8be256cd8e32188b5 750 SUPERFAMILY SSF142764 9 266 2.09E-32 T 17-03-2017 SHXM_RS08240 20ec7a34706d33c8be256cd8e32188b5 750 Pfam PF17042 Putative nucleotide-binding of sugar-metabolising enzyme 651 732 2.4E-12 T 17-03-2017 IPR031475 Putative nucleotide-binding C-terminal domain SHXM_RS08240 20ec7a34706d33c8be256cd8e32188b5 750 SUPERFAMILY SSF142764 648 739 5.89E-13 T 17-03-2017 SHXM_RS08240 20ec7a34706d33c8be256cd8e32188b5 750 Pfam PF07005 Putative sugar-binding N-terminal domain 9 249 2.6E-33 T 17-03-2017 IPR010737 Putative sugar-binding, N-terminal domain SHXM_RS17470 59de9fd2086f99460750c052320e5bda 623 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 411 612 1.8E-36 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS17470 59de9fd2086f99460750c052320e5bda 623 Gene3D G3DSA:3.30.450.40 217 361 5.3E-8 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS17470 59de9fd2086f99460750c052320e5bda 623 Pfam PF13581 Histidine kinase-like ATPase domain 38 164 4.7E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17470 59de9fd2086f99460750c052320e5bda 623 SMART SM00331 384 613 1.0E-33 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS17470 59de9fd2086f99460750c052320e5bda 623 SUPERFAMILY SSF55781 246 362 6.28E-8 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS49260 a2c2ba0c0d11ccf215a9a0c74ca03259 297 Gene3D G3DSA:2.60.40.10 57 125 4.4E-10 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS49260 a2c2ba0c0d11ccf215a9a0c74ca03259 297 Pfam PF01833 IPT/TIG domain 51 125 5.6E-7 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS49260 a2c2ba0c0d11ccf215a9a0c74ca03259 297 SUPERFAMILY SSF81296 57 127 6.02E-9 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS18400 a2f06246ad0b9576f63547601afe8d5e 243 Gene3D G3DSA:3.20.20.70 7 240 3.4E-71 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18400 a2f06246ad0b9576f63547601afe8d5e 243 SUPERFAMILY SSF51366 7 239 2.28E-63 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS18400 a2f06246ad0b9576f63547601afe8d5e 243 Hamap MF_01014 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase [hisA]. 7 240 31.63 T 17-03-2017 IPR023016 Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GO:0000105|GO:0003949 KEGG: 00340+5.3.1.16 SHXM_RS18400 a2f06246ad0b9576f63547601afe8d5e 243 Pfam PF00977 Histidine biosynthesis protein 8 233 2.3E-62 T 17-03-2017 IPR006062 Histidine biosynthesis GO:0000105 SHXM_RS18400 a2f06246ad0b9576f63547601afe8d5e 243 TIGRFAM TIGR01919 hisA-trpF: bifunctional HisA/TrpF protein 6 241 3.2E-118 T 17-03-2017 IPR010188 Bifunctional HisA/TrpF GO:0000105|GO:0000162|GO:0003949|GO:0004640|GO:0005737 KEGG: 00340+5.3.1.16 SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 38 806 1.6E-157 T 17-03-2017 IPR005887 Alpha-1,2-mannosidase, putative SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 Pfam PF07971 Glycosyl hydrolase family 92 299 802 2.0E-146 T 17-03-2017 IPR012939 Glycosyl hydrolase family 92 SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 Gene3D G3DSA:1.20.1610.10 515 671 6.6E-39 T 17-03-2017 SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 SUPERFAMILY SSF48208 325 780 1.62E-16 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 Gene3D G3DSA:2.70.98.10 50 383 2.0E-89 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 Gene3D G3DSA:1.20.1050.60 409 501 1.1E-22 T 17-03-2017 SHXM_RS03875 b8fe9b769410fa1a3ca9938a719faef7 818 Gene3D G3DSA:3.30.2080.10 672 812 4.6E-50 T 17-03-2017 SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 SMART SM00849 31 225 2.6E-22 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 PIRSF PIRSF004803 13 561 2.5E-205 T 17-03-2017 IPR030854 Ribonuclease J, bacteria GO:0004521|GO:0004534|GO:0006396|GO:0008270|GO:0090501 SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 TIGRFAM TIGR00649 MG423: beta-CASP ribonuclease, RNase J family 20 558 1.5E-151 T 17-03-2017 IPR004613 Ribonuclease J GO:0003723|GO:0046872 SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 Gene3D G3DSA:3.60.15.10 18 265 6.0E-77 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 SUPERFAMILY SSF56281 19 433 8.26E-97 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 Hamap MF_01491 Ribonuclease J [rnj]. 14 561 40.723 T 17-03-2017 IPR030854 Ribonuclease J, bacteria GO:0004521|GO:0004534|GO:0006396|GO:0008270|GO:0090501 SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 Pfam PF07521 Zn-dependent metallo-hydrolase RNA specificity domain 370 411 8.5E-10 T 17-03-2017 IPR011108 Zn-dependent metallo-hydrolase, RNA specificity domain SHXM_RS37110 27971cc665dc5261737b6c6ac3e2fa8c 561 Pfam PF00753 Metallo-beta-lactamase superfamily 28 174 4.1E-13 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41280 094d80e66488b973c59777551d690eac 303 Pfam PF06283 Trehalose utilisation 51 256 1.6E-28 T 17-03-2017 IPR029010 ThuA-like domain SHXM_RS41280 094d80e66488b973c59777551d690eac 303 Gene3D G3DSA:3.40.50.880 46 292 4.2E-17 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS41280 094d80e66488b973c59777551d690eac 303 SUPERFAMILY SSF52317 44 281 8.09E-25 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00145 Argininosuccinate lyase family signature 110 132 3.4E-54 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00145 Argininosuccinate lyase family signature 202 218 3.4E-54 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00145 Argininosuccinate lyase family signature 241 265 3.4E-54 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00145 Argininosuccinate lyase family signature 285 301 3.4E-54 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00145 Argininosuccinate lyase family signature 151 171 3.4E-54 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00145 Argininosuccinate lyase family signature 320 339 3.4E-54 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 Hamap MF_00006 Argininosuccinate lyase [argH]. 10 463 40.72 T 17-03-2017 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 Gene3D G3DSA:1.10.275.10 10 115 2.8E-35 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 TIGRFAM TIGR00838 argH: argininosuccinate lyase 11 465 3.9E-180 T 17-03-2017 IPR009049 Argininosuccinate lyase GO:0004056|GO:0042450 KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 Gene3D G3DSA:1.20.200.10 116 383 2.7E-98 T 17-03-2017 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 Pfam PF00206 Lyase 14 310 6.1E-65 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 ProSitePatterns PS00163 Fumarate lyases signature. 285 294 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00149 Fumarate lyase superfamily signature 241 268 1.4E-26 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00149 Fumarate lyase superfamily signature 156 174 1.4E-26 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00149 Fumarate lyase superfamily signature 285 301 1.4E-26 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 PRINTS PR00149 Fumarate lyase superfamily signature 111 129 1.4E-26 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 Pfam PF14698 Argininosuccinate lyase C-terminal 373 438 7.6E-21 T 17-03-2017 IPR029419 Argininosuccinate lyase, C-terminal KEGG: 00220+4.3.2.1|KEGG: 00250+4.3.2.1|MetaCyc: PWY-4983|MetaCyc: PWY-4984|MetaCyc: PWY-5|MetaCyc: PWY-5154|MetaCyc: PWY-7400|Reactome: R-HSA-70635 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 SUPERFAMILY SSF48557 14 465 2.36E-137 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS12870 9131a723809e5b7bde8c2ab8c1946609 476 Gene3D G3DSA:1.10.40.30 384 440 3.3E-27 T 17-03-2017 SHXM_RS32365 c500b59fe425d5a9b63f9f253a6d60f4 314 SUPERFAMILY SSF53613 1 291 2.81E-59 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS32365 c500b59fe425d5a9b63f9f253a6d60f4 314 PIRSF PIRSF000535 1 300 1.5E-73 T 17-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 SHXM_RS32365 c500b59fe425d5a9b63f9f253a6d60f4 314 Gene3D G3DSA:3.40.1190.20 32 294 2.7E-70 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS32365 c500b59fe425d5a9b63f9f253a6d60f4 314 TIGRFAM TIGR03168 1-PFK: hexose kinase, 1-phosphofructokinase family 2 295 7.2E-98 T 17-03-2017 IPR017583 Tagatose/fructose phosphokinase GO:0005975|GO:0016773 SHXM_RS32365 c500b59fe425d5a9b63f9f253a6d60f4 314 Pfam PF00294 pfkB family carbohydrate kinase 24 290 1.5E-35 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS32365 c500b59fe425d5a9b63f9f253a6d60f4 314 TIGRFAM TIGR03828 pfkB: 1-phosphofructokinase 2 295 4.6E-98 T 17-03-2017 IPR022463 Fructose 1-phosphate kinase GO:0008662 KEGG: 00051+2.7.1.56 SHXM_RS39190 5a01ba35ee9e14ce91b31ee8e91b9c7e 102 Pfam PF01527 Transposase 3 82 7.6E-13 T 17-03-2017 IPR002514 Transposase IS3/IS911family GO:0003677|GO:0004803|GO:0006313 SHXM_RS39190 5a01ba35ee9e14ce91b31ee8e91b9c7e 102 SUPERFAMILY SSF46689 4 94 1.97E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39190 5a01ba35ee9e14ce91b31ee8e91b9c7e 102 Gene3D G3DSA:1.10.10.60 10 90 2.3E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 SMART SM00354 9 79 2.1E-22 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 Gene3D G3DSA:1.10.260.40 10 61 4.5E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 SUPERFAMILY SSF47413 8 67 1.61E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 Gene3D G3DSA:3.40.50.2300 182 312 2.7E-34 T 17-03-2017 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 ProSitePatterns PS00356 LacI-type HTH domain signature. 12 30 - T 17-03-2017 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 Gene3D G3DSA:3.40.50.2300 62 181 1.8E-31 T 17-03-2017 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 Pfam PF13377 Periplasmic binding protein-like domain 177 335 3.4E-30 T 17-03-2017 SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 SUPERFAMILY SSF53822 66 322 4.35E-52 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS31680 baa50b87d6c76302f7ba4326b34a9520 345 Pfam PF00356 Bacterial regulatory proteins, lacI family 11 56 8.5E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS48340 ac3ee76b57a715b293087ef6d57270d8 438 Pfam PF01547 Bacterial extracellular solute-binding protein 60 336 1.2E-24 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS48340 ac3ee76b57a715b293087ef6d57270d8 438 Gene3D G3DSA:3.40.190.10 328 360 2.5E-12 T 17-03-2017 SHXM_RS48340 ac3ee76b57a715b293087ef6d57270d8 438 Gene3D G3DSA:3.40.190.10 43 150 2.5E-12 T 17-03-2017 SHXM_RS48340 ac3ee76b57a715b293087ef6d57270d8 438 SUPERFAMILY SSF53850 29 437 1.75E-51 T 17-03-2017 SHXM_RS48340 ac3ee76b57a715b293087ef6d57270d8 438 Gene3D G3DSA:3.40.190.10 152 327 2.9E-33 T 17-03-2017 SHXM_RS01685 80b689795f8102a3627fc0439bc23060 609 Gene3D G3DSA:3.50.50.60 546 593 2.4E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01685 80b689795f8102a3627fc0439bc23060 609 Gene3D G3DSA:3.50.50.60 5 178 2.4E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01685 80b689795f8102a3627fc0439bc23060 609 SUPERFAMILY SSF51905 6 70 9.07E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01685 80b689795f8102a3627fc0439bc23060 609 SUPERFAMILY SSF51905 99 175 9.07E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01685 80b689795f8102a3627fc0439bc23060 609 Pfam PF13454 FAD-NAD(P)-binding 9 171 5.0E-39 T 17-03-2017 SHXM_RS23420 01392268c188dbdae5e1038d58458598 470 Pfam PF00324 Amino acid permease 19 447 2.5E-109 T 17-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 SHXM_RS23420 01392268c188dbdae5e1038d58458598 470 PIRSF PIRSF006060 1 469 1.5E-64 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS23420 01392268c188dbdae5e1038d58458598 470 ProSitePatterns PS00218 Amino acid permeases signature. 43 73 - T 17-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 Gene3D G3DSA:1.10.10.10 3 82 3.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 64 1.6E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 SUPERFAMILY SSF53850 90 300 5.16E-25 T 17-03-2017 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 SUPERFAMILY SSF46785 5 88 1.26E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 Pfam PF03466 LysR substrate binding domain 90 295 5.7E-24 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 6.4E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 6.4E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 6.4E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 Gene3D G3DSA:3.40.190.10 92 176 3.4E-14 T 17-03-2017 SHXM_RS11755 9e3c650095518ca00a56a108a570ce73 309 Gene3D G3DSA:3.40.190.10 177 253 1.1E-15 T 17-03-2017 SHXM_RS05805 e95c1bd6f857e44fd06bebeb4a11fea2 177 Gene3D G3DSA:2.40.50.230 22 88 1.0E-7 T 17-03-2017 IPR006531 Gp5 N-terminal SHXM_RS05805 e95c1bd6f857e44fd06bebeb4a11fea2 177 SUPERFAMILY SSF69255 8 88 1.57E-14 T 17-03-2017 SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 Gene3D G3DSA:1.10.260.40 5 83 2.3E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 Pfam PF07883 Cupin domain 105 171 1.1E-17 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 SUPERFAMILY SSF47413 4 64 4.22E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 Gene3D G3DSA:2.60.120.10 93 177 5.9E-25 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 Pfam PF01381 Helix-turn-helix 6 57 1.6E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 SUPERFAMILY SSF51182 45 177 2.9E-28 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS49460 98c4f330a166fad9cfde05f6d61a3f8f 178 SMART SM00530 5 60 1.3E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS35335 b986ff9c265646422421d513c38318d9 346 Gene3D G3DSA:3.20.20.30 1 346 4.8E-89 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS35335 b986ff9c265646422421d513c38318d9 346 Pfam PF00296 Luciferase-like monooxygenase 1 315 6.6E-57 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS35335 b986ff9c265646422421d513c38318d9 346 SUPERFAMILY SSF51679 1 346 3.01E-70 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS45800 70063a0b5e8ba1aa812f0bf8920b8bf9 445 Gene3D G3DSA:3.40.630.10 341 396 5.2E-4 T 17-03-2017 SHXM_RS45800 70063a0b5e8ba1aa812f0bf8920b8bf9 445 Gene3D G3DSA:3.30.70.360 227 337 9.2E-8 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS45800 70063a0b5e8ba1aa812f0bf8920b8bf9 445 Gene3D G3DSA:3.40.630.10 26 226 4.4E-20 T 17-03-2017 SHXM_RS45800 70063a0b5e8ba1aa812f0bf8920b8bf9 445 SUPERFAMILY SSF55031 218 337 6.63E-6 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS45800 70063a0b5e8ba1aa812f0bf8920b8bf9 445 SUPERFAMILY SSF53187 20 231 3.59E-27 T 17-03-2017 SHXM_RS45800 70063a0b5e8ba1aa812f0bf8920b8bf9 445 SUPERFAMILY SSF53187 349 428 3.59E-27 T 17-03-2017 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 SUPERFAMILY SSF63737 3 198 3.14E-35 T 17-03-2017 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 Gene3D G3DSA:1.10.390.10 309 456 2.9E-40 T 17-03-2017 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 Pfam PF11838 ERAP1-like C-terminal domain 533 848 1.1E-50 T 17-03-2017 IPR024571 ERAP1-like C-terminal domain SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 Pfam PF01433 Peptidase family M1 90 391 9.1E-68 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 315 327 7.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 135 150 7.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 181 196 7.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 296 311 7.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 262 272 7.1E-21 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 TIGRFAM TIGR02412 pepN_strep_liv: aminopeptidase N 4 854 0.0 T 17-03-2017 IPR012778 Peptidase M1, aminopeptidase GO:0004177|GO:0006508 KEGG: 00480+3.4.11.2|MetaCyc: PWY-4061|MetaCyc: PWY-6842|MetaCyc: PWY-7112 SHXM_RS18225 2d2e88ab3dbcbc3fe2ac5feee50823ef 858 SUPERFAMILY SSF55486 214 455 3.22E-72 T 17-03-2017 SHXM_RS23505 22208f77aebe3a5056dd2f629ab9a94a 400 Gene3D G3DSA:3.40.50.150 18 259 7.7E-48 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS23505 22208f77aebe3a5056dd2f629ab9a94a 400 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 105 225 1.6E-24 T 17-03-2017 SHXM_RS23505 22208f77aebe3a5056dd2f629ab9a94a 400 SUPERFAMILY SSF53335 16 45 1.9E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS23505 22208f77aebe3a5056dd2f629ab9a94a 400 SUPERFAMILY SSF53335 112 224 1.9E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12670 b55c463bc151a22277aa940790f2e259 151 Pfam PF09656 Putative transmembrane protein (PGPGW) 50 102 1.4E-20 T 17-03-2017 IPR019099 Uncharacterised protein family PGPGW, transmembrane SHXM_RS12670 b55c463bc151a22277aa940790f2e259 151 TIGRFAM TIGR02611 TIGR02611: TIGR02611 family protein 33 145 2.0E-34 T 17-03-2017 IPR013434 Conserved hypothetical protein CHP02611 SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 SUPERFAMILY SSF55920 1 253 7.07E-60 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 Gene3D G3DSA:3.90.230.10 1 256 5.4E-58 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 Pfam PF00557 Metallopeptidase family M24 16 246 6.2E-34 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 TIGRFAM TIGR00500 met_pdase_I: methionine aminopeptidase, type I 2 253 3.2E-63 T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 PRINTS PR00599 Methionine aminopeptidase-1 signature 95 111 3.1E-13 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 PRINTS PR00599 Methionine aminopeptidase-1 signature 197 209 3.1E-13 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 PRINTS PR00599 Methionine aminopeptidase-1 signature 73 86 3.1E-13 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 PRINTS PR00599 Methionine aminopeptidase-1 signature 166 178 3.1E-13 T 17-03-2017 IPR001714 Peptidase M24, methionine aminopeptidase SHXM_RS27465 2e7a5ebb21c0e2dfdbe93464922bcd99 260 Hamap MF_01974 Methionine aminopeptidase [map]. 2 255 29.926 T 17-03-2017 IPR002467 Peptidase M24A, methionine aminopeptidase, subfamily 1 GO:0004177|GO:0006508|GO:0008235 SHXM_RS26600 42218ba726e1477e66a204c12f8dbef9 392 Pfam PF00082 Subtilase family 61 313 9.6E-30 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS26600 42218ba726e1477e66a204c12f8dbef9 392 PRINTS PR00723 Subtilisin serine protease family (S8) signature 104 117 4.1E-12 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS26600 42218ba726e1477e66a204c12f8dbef9 392 PRINTS PR00723 Subtilisin serine protease family (S8) signature 262 278 4.1E-12 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS26600 42218ba726e1477e66a204c12f8dbef9 392 PRINTS PR00723 Subtilisin serine protease family (S8) signature 61 80 4.1E-12 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS26600 42218ba726e1477e66a204c12f8dbef9 392 SUPERFAMILY SSF52743 44 322 2.23E-64 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS26600 42218ba726e1477e66a204c12f8dbef9 392 Gene3D G3DSA:3.40.50.200 41 321 2.3E-67 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 Gene3D G3DSA:3.40.50.1820 186 312 8.5E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 Gene3D G3DSA:3.40.50.1820 57 142 8.5E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 Gene3D G3DSA:3.40.50.1820 363 485 8.5E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 SUPERFAMILY SSF53474 72 137 1.99E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 SUPERFAMILY SSF53474 407 468 1.99E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 SUPERFAMILY SSF53474 303 349 1.99E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 SUPERFAMILY SSF53474 177 241 1.99E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 Pfam PF00561 alpha/beta hydrolase fold 93 287 1.0E-21 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS30520 fc9fa8961271830a6f7cb590a4c4ad7d 498 Pfam PF08386 TAP-like protein 403 497 3.5E-20 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS06935 974df21186b67eb3f174cda3ef9064e9 605 SUPERFAMILY SSF51126 317 547 4.5E-5 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 143 158 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 262 279 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 366 382 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 165 182 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 114 129 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 61 78 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 199 216 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 38 54 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 PRINTS PR01758 Capsule biosynthesis protein CapB signature 297 312 1.7E-33 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 Pfam PF08245 Mur ligase middle domain 41 200 2.0E-6 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 Gene3D G3DSA:3.40.1190.10 37 240 1.4E-10 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 SUPERFAMILY SSF53623 36 238 6.11E-12 T 17-03-2017 IPR013221 Mur ligase, central GO:0005524|GO:0009058 Reactome: R-HSA-196757 SHXM_RS11050 d25064a8465fb52414743d924f1a73c6 509 TIGRFAM TIGR04012 poly_gGlu_PgsB: poly-gamma-glutamate synthase PgsB 7 387 4.4E-116 T 17-03-2017 IPR008337 Capsule biosynthesis protein CapB GO:0016020|GO:0045227 SHXM_RS26705 924aa081543f44658b53b6771814e5c6 389 Gene3D G3DSA:3.30.565.10 296 387 3.9E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26705 924aa081543f44658b53b6771814e5c6 389 SUPERFAMILY SSF55874 295 385 3.65E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26705 924aa081543f44658b53b6771814e5c6 389 Pfam PF07730 Histidine kinase 185 249 1.7E-16 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS26705 924aa081543f44658b53b6771814e5c6 389 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 296 385 2.5E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19825 b49be7f409dac95c7ee06b159c2f3b51 544 SUPERFAMILY SSF48264 71 451 4.71E-63 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19825 b49be7f409dac95c7ee06b159c2f3b51 544 Gene3D G3DSA:1.10.630.10 68 452 3.5E-85 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19825 b49be7f409dac95c7ee06b159c2f3b51 544 PRINTS PR00359 B-class P450 signature 347 374 1.1E-13 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19825 b49be7f409dac95c7ee06b159c2f3b51 544 PRINTS PR00359 B-class P450 signature 251 273 1.1E-13 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19825 b49be7f409dac95c7ee06b159c2f3b51 544 PRINTS PR00359 B-class P450 signature 154 165 1.1E-13 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19825 b49be7f409dac95c7ee06b159c2f3b51 544 PRINTS PR00359 B-class P450 signature 200 216 1.1E-13 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS46290 72f2aed0912afb0e7256bc36275805b3 410 Pfam PF07690 Major Facilitator Superfamily 10 298 9.9E-29 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46290 72f2aed0912afb0e7256bc36275805b3 410 SUPERFAMILY SSF103473 3 388 1.96E-49 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS46290 72f2aed0912afb0e7256bc36275805b3 410 Gene3D G3DSA:1.20.1250.20 4 184 4.3E-18 T 17-03-2017 SHXM_RS46290 72f2aed0912afb0e7256bc36275805b3 410 Gene3D G3DSA:1.20.1250.20 204 384 4.4E-12 T 17-03-2017 SHXM_RS21110 fa0dd14ecb9ed8798c29b2d3591b339f 316 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 34 299 3.9E-19 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS21110 fa0dd14ecb9ed8798c29b2d3591b339f 316 SUPERFAMILY SSF52266 30 309 1.28E-53 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS21110 fa0dd14ecb9ed8798c29b2d3591b339f 316 Gene3D G3DSA:3.40.50.1110 27 309 4.7E-63 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 SUPERFAMILY SSF90123 65 365 3.01E-16 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 Gene3D G3DSA:3.40.50.300 399 627 9.3E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 Gene3D G3DSA:1.20.1560.10 69 365 2.0E-12 T 17-03-2017 SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 SUPERFAMILY SSF52540 396 639 1.36E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 Pfam PF00005 ABC transporter 417 569 2.6E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 SMART SM00382 426 615 3.1E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS19130 02d80fec83d52a1972903e9bb9efb423 652 ProSitePatterns PS00211 ABC transporters family signature. 541 555 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS29250 5f4f4ad313bfb8d123c64345b57e296d 137 PIRSF PIRSF017349 1 137 8.4E-67 T 17-03-2017 IPR014487 Protein of unknown function DUF3151 SHXM_RS29250 5f4f4ad313bfb8d123c64345b57e296d 137 Pfam PF11349 Protein of unknown function (DUF3151) 10 134 1.1E-58 T 17-03-2017 IPR014487 Protein of unknown function DUF3151 SHXM_RS23535 6b5cad1ad889ad58eaeb84931da21bab 319 Gene3D G3DSA:3.60.15.10 105 297 1.0E-46 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23535 6b5cad1ad889ad58eaeb84931da21bab 319 SMART SM00849 121 282 5.6E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23535 6b5cad1ad889ad58eaeb84931da21bab 319 SUPERFAMILY SSF56281 109 294 2.38E-33 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23535 6b5cad1ad889ad58eaeb84931da21bab 319 Gene3D G3DSA:3.30.70.20 29 86 3.4E-4 T 17-03-2017 SHXM_RS23535 6b5cad1ad889ad58eaeb84931da21bab 319 Pfam PF00753 Metallo-beta-lactamase superfamily 122 265 3.4E-7 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23535 6b5cad1ad889ad58eaeb84931da21bab 319 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 28 86 1.5E-8 T 17-03-2017 SHXM_RS24825 cc60e062f021eaee2b67e8db8d1a07d5 254 Pfam PF01738 Dienelactone hydrolase family 77 206 6.8E-5 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS24825 cc60e062f021eaee2b67e8db8d1a07d5 254 Gene3D G3DSA:3.40.50.1820 28 215 6.2E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS24825 cc60e062f021eaee2b67e8db8d1a07d5 254 SUPERFAMILY SSF53474 51 215 1.12E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 Pfam PF00106 short chain dehydrogenase 6 189 9.9E-44 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 1.8E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 6 23 1.8E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 1.8E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 1.8E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 1.8E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 SUPERFAMILY SSF51735 5 244 1.01E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 Gene3D G3DSA:3.40.50.720 5 245 6.8E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 4.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 4.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS46890 d062e3e35373d6b8f362206b2b40b1ee 273 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 4.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04545 0a775de91165e0180717b30f0898b86a 393 Pfam PF07730 Histidine kinase 181 244 2.0E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS04545 0a775de91165e0180717b30f0898b86a 393 SUPERFAMILY SSF55874 269 381 7.34E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS38645 099c99ed7928971a95a82a690f2654cd 517 Pfam PF05036 Sporulation related domain 83 146 3.4E-4 T 17-03-2017 IPR007730 Sporulation-related domain GO:0042834 SHXM_RS38645 099c99ed7928971a95a82a690f2654cd 517 Pfam PF09992 Phosphodiester glycosidase 327 514 1.4E-31 T 17-03-2017 IPR018711 Phosphodiester glycosidase SHXM_RS38645 099c99ed7928971a95a82a690f2654cd 517 SUPERFAMILY SSF110997 80 147 9.29E-5 T 17-03-2017 IPR007730 Sporulation-related domain GO:0042834 SHXM_RS38645 099c99ed7928971a95a82a690f2654cd 517 Gene3D G3DSA:3.30.70.1070 82 147 1.9E-5 T 17-03-2017 IPR007730 Sporulation-related domain GO:0042834 SHXM_RS15075 61817b0a40602594727815afbe6bb8b8 188 SUPERFAMILY SSF53383 7 164 2.28E-12 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 TIGRFAM TIGR02135 phoU_full: phosphate transport system regulatory protein PhoU 4 212 1.1E-56 T 17-03-2017 IPR028366 Phosphate transport system protein PhoU GO:0005737|GO:0030643|GO:0045936 SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 Gene3D G3DSA:1.20.58.220 116 212 3.2E-21 T 17-03-2017 SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 Pfam PF01895 PhoU domain 121 204 3.4E-12 T 17-03-2017 IPR026022 PhoU domain SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 Pfam PF01895 PhoU domain 16 103 3.0E-17 T 17-03-2017 IPR026022 PhoU domain SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 SUPERFAMILY SSF109755 2 220 1.57E-59 T 17-03-2017 SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 PIRSF PIRSF003107 1 217 1.5E-54 T 17-03-2017 IPR028366 Phosphate transport system protein PhoU GO:0005737|GO:0030643|GO:0045936 SHXM_RS26050 ecbd2dd17c1897df2d0bc07738e6b88e 225 Gene3D G3DSA:1.20.58.220 1 105 2.3E-28 T 17-03-2017 SHXM_RS49485 23bf07fba449503053715a0a880385a2 325 Pfam PF06007 Phosphonate metabolism protein PhnJ 28 294 7.0E-116 T 17-03-2017 IPR010306 Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase GO:0016829|GO:0019700|GO:0051539 KEGG: 00440+4.7.1.1|MetaCyc: PWY-7399 SHXM_RS49485 23bf07fba449503053715a0a880385a2 325 PIRSF PIRSF011468 25 316 2.2E-109 T 17-03-2017 IPR010306 Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase GO:0016829|GO:0019700|GO:0051539 KEGG: 00440+4.7.1.1|MetaCyc: PWY-7399 SHXM_RS11170 ad108dcc1f64e9aefa9a5018aab80e1b 313 SUPERFAMILY SSF51735 10 309 1.88E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11170 ad108dcc1f64e9aefa9a5018aab80e1b 313 Gene3D G3DSA:3.40.50.720 12 302 3.8E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11170 ad108dcc1f64e9aefa9a5018aab80e1b 313 Pfam PF01370 NAD dependent epimerase/dehydratase family 10 206 5.6E-13 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS37690 c753f1ee79712ac7b80b2085d9a44eb9 204 Gene3D G3DSA:3.40.50.300 20 192 4.6E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37690 c753f1ee79712ac7b80b2085d9a44eb9 204 SUPERFAMILY SSF52540 22 200 1.53E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37690 c753f1ee79712ac7b80b2085d9a44eb9 204 Pfam PF03029 Conserved hypothetical ATP binding protein 26 192 7.6E-21 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS28885 5b2551e3f5f71e5348f2ea0ba28782a2 157 SUPERFAMILY SSF55729 6 148 9.43E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28885 5b2551e3f5f71e5348f2ea0ba28782a2 157 Pfam PF13673 Acetyltransferase (GNAT) domain 55 137 4.0E-11 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS28885 5b2551e3f5f71e5348f2ea0ba28782a2 157 Gene3D G3DSA:3.40.630.30 6 149 1.4E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38195 bd00b20fc4165e0c702f88e8b90dd19b 262 Pfam PF00005 ABC transporter 25 175 1.9E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS38195 bd00b20fc4165e0c702f88e8b90dd19b 262 SUPERFAMILY SSF52540 8 225 1.09E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38195 bd00b20fc4165e0c702f88e8b90dd19b 262 SMART SM00382 34 223 4.7E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS38195 bd00b20fc4165e0c702f88e8b90dd19b 262 Gene3D G3DSA:3.40.50.300 6 223 2.6E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00685 881cc52747ff2a20a9123d8c691fb816 160 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 11 87 3.0E-21 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS05000 80081194d1920a2132f11abb99e06007 876 SUPERFAMILY SSF56112 192 407 9.98E-35 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS05000 80081194d1920a2132f11abb99e06007 876 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature. 257 269 - T 17-03-2017 IPR008266 Tyrosine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS05000 80081194d1920a2132f11abb99e06007 876 Gene3D G3DSA:1.10.510.10 221 398 3.8E-30 T 17-03-2017 SHXM_RS05000 80081194d1920a2132f11abb99e06007 876 SMART SM00220 141 394 4.2E-11 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS05000 80081194d1920a2132f11abb99e06007 876 Pfam PF00069 Protein kinase domain 233 392 1.8E-19 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS32085 bcce376ab99319b915783b19ece1e422 319 Gene3D G3DSA:3.40.50.1820 24 291 6.2E-30 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32085 bcce376ab99319b915783b19ece1e422 319 Pfam PF12740 Chlorophyllase enzyme 42 156 1.2E-8 T 17-03-2017 IPR017395 Chlorophyllase GO:0015996|GO:0047746 KEGG: 00860+3.1.1.14|MetaCyc: PWY-5098|MetaCyc: PWY-6927|MetaCyc: PWY-7164 SHXM_RS32085 bcce376ab99319b915783b19ece1e422 319 SUPERFAMILY SSF53474 15 256 6.03E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 Gene3D G3DSA:3.30.413.10 460 530 3.1E-5 T 17-03-2017 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 Gene3D G3DSA:3.30.413.10 385 412 3.1E-5 T 17-03-2017 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 309 370 5.4E-11 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 Pfam PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain 41 98 3.0E-11 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 SUPERFAMILY SSF56014 382 411 1.31E-5 T 17-03-2017 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 SUPERFAMILY SSF56014 458 530 1.31E-5 T 17-03-2017 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 SUPERFAMILY SSF56014 108 195 1.02E-5 T 17-03-2017 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 SUPERFAMILY SSF55124 238 376 1.08E-21 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 Gene3D G3DSA:3.90.480.10 299 376 2.8E-27 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 Gene3D G3DSA:3.90.480.10 36 105 2.8E-27 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS07300 811b07efbc1c1d44b81ef3e45e717dda 535 SUPERFAMILY SSF55124 22 102 1.96E-21 T 17-03-2017 IPR005117 Nitrite/Sulfite reductase ferredoxin-like domain GO:0016491|GO:0055114 KEGG: 00920+1.8.1.2|MetaCyc: PWY-6683 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 Gene3D G3DSA:1.20.1050.60 369 460 9.5E-26 T 17-03-2017 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 Gene3D G3DSA:2.70.98.10 46 343 2.0E-104 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 SUPERFAMILY SSF48208 292 764 3.23E-22 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 Pfam PF07971 Glycosyl hydrolase family 92 261 778 2.0E-146 T 17-03-2017 IPR012939 Glycosyl hydrolase family 92 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 Gene3D G3DSA:1.20.1610.10 466 639 6.3E-50 T 17-03-2017 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 Gene3D G3DSA:3.30.2080.10 640 787 2.7E-49 T 17-03-2017 SHXM_RS07585 da30b4b2deeadb82e60fc88ebf3147b7 801 TIGRFAM TIGR01180 aman2_put: putative alpha-1,2-mannosidase 46 781 5.8E-170 T 17-03-2017 IPR005887 Alpha-1,2-mannosidase, putative SHXM_RS45605 05b16d085f84b0dbfae78654780ab2cc 244 Pfam PF12697 Alpha/beta hydrolase family 5 238 1.2E-14 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45605 05b16d085f84b0dbfae78654780ab2cc 244 SUPERFAMILY SSF53474 5 242 3.82E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45605 05b16d085f84b0dbfae78654780ab2cc 244 Gene3D G3DSA:3.40.50.1820 3 242 1.5E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 Gene3D G3DSA:3.20.20.70 1 359 1.5E-123 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 PIRSF PIRSF036915 1 372 1.2E-178 T 17-03-2017 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 SUPERFAMILY SSF51569 4 359 4.27E-78 T 17-03-2017 SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 TIGRFAM TIGR00876 tal_mycobact: transaldolase 12 359 1.5E-135 T 17-03-2017 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 Pfam PF00923 Transaldolase 15 359 5.3E-84 T 17-03-2017 IPR001585 Transaldolase/Fructose-6-phosphate aldolase GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336 SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 Hamap MF_00493 Transaldolase [tal]. 1 370 163.024 T 17-03-2017 IPR004732 Transaldolase type 2 GO:0004801|GO:0005737|GO:0006098 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723 SHXM_RS17875 743fe8b1e1d4159bbd6b2a6f52b6f056 372 ProSitePatterns PS01054 Transaldolase signature 1. 41 49 - T 17-03-2017 IPR018225 Transaldolase, active site GO:0005975 KEGG: 00030+2.2.1.2|MetaCyc: PWY-1861|MetaCyc: PWY-5723|Reactome: R-HSA-163754|Reactome: R-HSA-6791055|Reactome: R-HSA-6791462|Reactome: R-HSA-71336 SHXM_RS03895 da4c10b23d76ba4ca1bb1a4384594a08 317 SUPERFAMILY SSF161098 77 302 9.29E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03895 da4c10b23d76ba4ca1bb1a4384594a08 317 Gene3D G3DSA:1.10.3720.10 86 311 1.2E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03895 da4c10b23d76ba4ca1bb1a4384594a08 317 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 118 312 6.5E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS16275 3ed8e3ac9003cc4a60df96da2e2d17ec 397 Pfam PF13439 Glycosyltransferase Family 4 12 171 7.8E-24 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS16275 3ed8e3ac9003cc4a60df96da2e2d17ec 397 Gene3D G3DSA:3.40.50.2000 154 306 8.2E-27 T 17-03-2017 SHXM_RS16275 3ed8e3ac9003cc4a60df96da2e2d17ec 397 SUPERFAMILY SSF53756 2 370 5.23E-67 T 17-03-2017 SHXM_RS16275 3ed8e3ac9003cc4a60df96da2e2d17ec 397 Pfam PF13692 Glycosyl transferases group 1 196 337 4.8E-18 T 17-03-2017 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 Pfam PF00067 Cytochrome P450 7 57 2.7E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 29 38 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 PRINTS PR00359 B-class P450 signature 6 21 9.5E-10 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 PRINTS PR00359 B-class P450 signature 27 36 9.5E-10 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 PRINTS PR00359 B-class P450 signature 36 47 9.5E-10 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 Gene3D G3DSA:1.10.630.10 2 89 3.2E-29 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05115 9dd5892ac1e142557589694a07d5a192 94 SUPERFAMILY SSF48264 3 88 4.85E-22 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 Pfam PF01494 FAD binding domain 2 339 1.4E-17 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 290 305 2.1E-13 T 17-03-2017 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 147 162 2.1E-13 T 17-03-2017 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 2.1E-13 T 17-03-2017 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 Gene3D G3DSA:3.50.50.60 1 173 3.7E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 Gene3D G3DSA:3.50.50.60 276 360 3.7E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 SUPERFAMILY SSF51905 3 168 2.99E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS17730 490264c9957c01fcf9fc57c47285dcdc 380 SUPERFAMILY SSF51905 275 369 2.99E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04480 953adba93f7e3caf37844f6c100b0830 152 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 1 131 2.2E-31 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS04480 953adba93f7e3caf37844f6c100b0830 152 ProSitePatterns PS01332 Rrf2-type HTH domain signature. 49 67 - T 17-03-2017 IPR030489 Transcription regulator Rrf2-type, conserved site SHXM_RS04480 953adba93f7e3caf37844f6c100b0830 152 Gene3D G3DSA:1.10.10.10 1 132 7.0E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04480 953adba93f7e3caf37844f6c100b0830 152 SUPERFAMILY SSF46785 2 132 9.52E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04480 953adba93f7e3caf37844f6c100b0830 152 Pfam PF02082 Transcriptional regulator 1 83 3.1E-25 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS47910 7c058aae08518587729d71a65a77a6af 401 Gene3D G3DSA:3.40.50.10540 6 221 5.6E-114 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47910 7c058aae08518587729d71a65a77a6af 401 Gene3D G3DSA:3.40.50.10540 310 401 5.6E-114 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47910 7c058aae08518587729d71a65a77a6af 401 Pfam PF02515 CoA-transferase family III 10 377 5.6E-121 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS47910 7c058aae08518587729d71a65a77a6af 401 SUPERFAMILY SSF89796 7 401 3.14E-131 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS47910 7c058aae08518587729d71a65a77a6af 401 Gene3D G3DSA:3.30.1540.10 227 309 3.0E-24 T 17-03-2017 SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 Gene3D G3DSA:2.30.40.10 6 81 1.3E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 Gene3D G3DSA:3.20.20.140 179 463 7.0E-36 T 17-03-2017 SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 Pfam PF07969 Amidohydrolase family 45 519 1.6E-82 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 SUPERFAMILY SSF51556 172 481 3.08E-31 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 SUPERFAMILY SSF51556 56 114 3.08E-31 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 SUPERFAMILY SSF51338 4 57 7.78E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 SUPERFAMILY SSF51338 480 519 7.78E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS46760 e7d739a94c85d7e04039894585c3b823 525 Gene3D G3DSA:2.30.40.10 464 499 2.1E-6 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS20280 8f532e7343df84c669ba8ebb8e011a96 347 Pfam PF00248 Aldo/keto reductase family 25 326 3.7E-65 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS20280 8f532e7343df84c669ba8ebb8e011a96 347 Gene3D G3DSA:3.20.20.100 11 339 2.3E-101 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS20280 8f532e7343df84c669ba8ebb8e011a96 347 SUPERFAMILY SSF51430 12 327 1.1E-87 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS24830 5bc9f44a67c25c015a16baa02f781f57 464 SUPERFAMILY SSF103473 56 448 2.75E-58 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS24830 5bc9f44a67c25c015a16baa02f781f57 464 Pfam PF07690 Major Facilitator Superfamily 73 288 7.5E-27 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS24830 5bc9f44a67c25c015a16baa02f781f57 464 Gene3D G3DSA:1.20.1250.20 70 246 1.8E-26 T 17-03-2017 SHXM_RS24830 5bc9f44a67c25c015a16baa02f781f57 464 Gene3D G3DSA:1.20.1250.20 272 452 1.4E-13 T 17-03-2017 SHXM_RS24830 5bc9f44a67c25c015a16baa02f781f57 464 ProSitePatterns PS00216 Sugar transport proteins signature 1. 122 138 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS27460 dbc347a625530372314f71b2bc71b730 100 SMART SM00530 20 74 9.7E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS27460 dbc347a625530372314f71b2bc71b730 100 Gene3D G3DSA:1.10.260.40 8 76 4.2E-26 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS27460 dbc347a625530372314f71b2bc71b730 100 SUPERFAMILY SSF47413 8 79 6.82E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS27460 dbc347a625530372314f71b2bc71b730 100 Pfam PF13560 Helix-turn-helix domain 16 73 2.5E-9 T 17-03-2017 SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 SUPERFAMILY SSF56784 1 219 9.3E-38 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 93 162 7.0E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 Gene3D G3DSA:3.40.50.1000 3 217 1.3E-29 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 Pfam PF13419 Haloacid dehalogenase-like hydrolase 88 168 8.8E-8 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 181 194 4.4E-5 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 2 13 4.4E-5 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS04455 450a3dc8bc96fb800fa66e0dd6208ec2 221 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 134 150 4.4E-5 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS11685 227dea4da962b086390ea407df833393 284 SUPERFAMILY SSF161098 16 284 3.83E-67 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11685 227dea4da962b086390ea407df833393 284 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 115 277 2.5E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11685 227dea4da962b086390ea407df833393 284 Gene3D G3DSA:1.10.3720.10 13 271 2.6E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31345 86aafdd3eec20f5171ccde342cd6215e 402 SUPERFAMILY SSF81606 203 354 1.8E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS31345 86aafdd3eec20f5171ccde342cd6215e 402 SMART SM00331 186 399 4.9E-23 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS31345 86aafdd3eec20f5171ccde342cd6215e 402 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 215 399 2.7E-32 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 Gene3D G3DSA:3.40.50.300 4 257 4.1E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 235 305 2.9E-20 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 SMART SM00382 33 233 3.7E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 SUPERFAMILY SSF52540 4 254 3.8E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 233 316 1.4E-23 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 Pfam PF00005 ABC transporter 26 183 1.3E-22 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33900 64b114574552e781d92fced15a4e098c 358 ProSitePatterns PS00211 ABC transporters family signature. 156 170 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS48620 8e807160ab27543d3ffc12b94c75bdeb 540 SUPERFAMILY SSF52096 30 275 4.98E-51 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS48620 8e807160ab27543d3ffc12b94c75bdeb 540 Gene3D G3DSA:3.90.226.10 32 271 3.2E-48 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS48620 8e807160ab27543d3ffc12b94c75bdeb 540 Gene3D G3DSA:3.90.226.10 272 524 4.9E-55 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS48620 8e807160ab27543d3ffc12b94c75bdeb 540 SUPERFAMILY SSF52096 242 519 6.75E-63 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS48620 8e807160ab27543d3ffc12b94c75bdeb 540 Pfam PF01039 Carboxyl transferase domain 50 517 1.0E-88 T 17-03-2017 IPR000022 Carboxyl transferase KEGG: 00061+6.4.1.2|KEGG: 00253+6.4.1.2|KEGG: 00254+6.4.1.2|KEGG: 00620+6.4.1.2|KEGG: 00640+6.4.1.2|KEGG: 00720+6.4.1.2|MetaCyc: PWY-4381|MetaCyc: PWY-5743|MetaCyc: PWY-5744|MetaCyc: PWY-5789|MetaCyc: PWY-6679|MetaCyc: PWY-6722|MetaCyc: PWY-7388|Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 SUPERFAMILY SSF63380 3 95 1.52E-21 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 SUPERFAMILY SSF52343 93 212 1.44E-24 T 17-03-2017 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 Pfam PF00175 Oxidoreductase NAD-binding domain 107 195 5.5E-5 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 SUPERFAMILY SSF54292 200 302 2.62E-24 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 229 293 1.3E-11 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 256 264 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 Gene3D G3DSA:2.40.30.10 3 96 1.7E-27 T 17-03-2017 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 Gene3D G3DSA:3.40.50.80 103 204 1.1E-20 T 17-03-2017 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 PRINTS PR00409 Phthalate dioxygenase reductase family signature 71 85 3.6E-26 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 PRINTS PR00409 Phthalate dioxygenase reductase family signature 182 190 3.6E-26 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 PRINTS PR00409 Phthalate dioxygenase reductase family signature 47 61 3.6E-26 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 PRINTS PR00409 Phthalate dioxygenase reductase family signature 35 47 3.6E-26 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 PRINTS PR00409 Phthalate dioxygenase reductase family signature 106 125 3.6E-26 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 PRINTS PR00409 Phthalate dioxygenase reductase family signature 25 35 3.6E-26 T 17-03-2017 IPR000951 Phthalate dioxygenase reductase GO:0016491 SHXM_RS45660 757a8a61514452a4fd5f235a4a116b1e 302 Gene3D G3DSA:3.10.20.30 205 300 4.2E-22 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS02050 b4cccb26449f634a51998bb8a9eae138 304 Gene3D G3DSA:1.10.3720.10 92 298 2.1E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02050 b4cccb26449f634a51998bb8a9eae138 304 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 25 72 1.4E-11 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS02050 b4cccb26449f634a51998bb8a9eae138 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 119 301 7.4E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02050 b4cccb26449f634a51998bb8a9eae138 304 SUPERFAMILY SSF161098 96 282 7.06E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05055 fbe0218d9d0e5c4cfda01605239f3221 388 Gene3D G3DSA:3.40.640.10 13 249 2.8E-70 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS05055 fbe0218d9d0e5c4cfda01605239f3221 388 SUPERFAMILY SSF53383 11 385 1.14E-99 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS05055 fbe0218d9d0e5c4cfda01605239f3221 388 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 18 379 7.2E-114 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS05055 fbe0218d9d0e5c4cfda01605239f3221 388 PIRSF PIRSF000390 6 387 1.5E-109 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS05055 fbe0218d9d0e5c4cfda01605239f3221 388 Gene3D G3DSA:3.90.1150.10 251 387 9.4E-56 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS16990 3de02aa59da165bdb92d3c5c279b3bd7 93 ProSitePatterns PS00234 Gas vesicles protein GVPa signature 1. 11 25 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS16990 3de02aa59da165bdb92d3c5c279b3bd7 93 Pfam PF00741 Gas vesicle protein 10 48 6.6E-17 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 Gene3D G3DSA:1.25.40.10 555 848 7.8E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 ProSitePatterns PS00622 LuxR-type HTH domain signature. 910 937 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 Gene3D G3DSA:1.10.10.10 893 949 8.2E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 Pfam PF13191 AAA ATPase domain 29 176 1.5E-15 T 17-03-2017 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 SUPERFAMILY SSF48452 386 416 3.26E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 SUPERFAMILY SSF48452 607 687 3.26E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 SUPERFAMILY SSF46894 892 950 2.62E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 SUPERFAMILY SSF52540 116 245 3.8E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 SUPERFAMILY SSF52540 29 78 3.8E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 SMART SM00421 893 950 2.8E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 Gene3D G3DSA:3.40.50.300 40 180 5.8E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 Pfam PF00196 Bacterial regulatory proteins, luxR family 896 947 1.7E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 910 926 4.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 896 910 4.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42790 e8c6968759a54a3ec73e89579c0819a9 962 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 926 938 4.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 SUPERFAMILY SSF54368 8 103 3.01E-30 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 SMART SM01230 104 363 2.6E-118 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 Pfam PF00120 Glutamine synthetase, catalytic domain 105 448 2.7E-123 T 17-03-2017 IPR008146 Glutamine synthetase, catalytic domain GO:0004356|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 Gene3D G3DSA:3.10.20.70 6 107 2.0E-38 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 ProSitePatterns PS00181 Glutamine synthetase putative ATP-binding region signature. 232 247 - T 17-03-2017 IPR027303 Glutamine synthetase, glycine-rich site KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964|Reactome: R-HSA-210455|Reactome: R-HSA-70614 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 Pfam PF03951 Glutamine synthetase, beta-Grasp domain 16 98 6.8E-28 T 17-03-2017 IPR008147 Glutamine synthetase, beta-Grasp domain GO:0004356|GO:0006542|GO:0006807 KEGG: 00220+6.3.1.2|KEGG: 00250+6.3.1.2|KEGG: 00630+6.3.1.2|KEGG: 00910+6.3.1.2|MetaCyc: PWY-381|MetaCyc: PWY-5675|MetaCyc: PWY-6549|MetaCyc: PWY-6963|MetaCyc: PWY-6964 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 SUPERFAMILY SSF55931 106 450 9.12E-113 T 17-03-2017 SHXM_RS19350 fc003602d2b19783c21f97298ede2b44 453 Gene3D G3DSA:3.30.590.10 108 440 1.9E-110 T 17-03-2017 IPR014746 Glutamine synthetase/guanido kinase, catalytic domain GO:0003824 SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 Pfam PF08281 Sigma-70, region 4 133 186 3.3E-17 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 Gene3D G3DSA:1.10.10.10 131 191 7.9E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 Gene3D G3DSA:1.10.1740.10 12 120 3.9E-19 T 17-03-2017 SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 SUPERFAMILY SSF88946 19 109 1.22E-16 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 SUPERFAMILY SSF88659 130 191 5.89E-18 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 Pfam PF04542 Sigma-70 region 2 31 101 4.1E-10 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29015 3006f438d0f6e6d5bfaabaeaa03f5b69 205 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 26 190 2.4E-24 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 SUPERFAMILY SSF51735 137 295 1.43E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 SUPERFAMILY SSF50129 1 163 2.28E-49 T 17-03-2017 IPR011032 GroES-like SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 131 9.7E-31 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 TIGRFAM TIGR02822 adh_fam_2: zinc-binding alcohol dehydrogenase family protein 10 325 3.2E-162 T 17-03-2017 IPR014187 Alcohol dehydrogenase, zinc-binding type 2 KEGG: 00010+1.1.1.1|KEGG: 00071+1.1.1.1|KEGG: 00260+1.1.1.1|KEGG: 00350+1.1.1.1|KEGG: 00592+1.1.1.1|KEGG: 00625+1.1.1.1|KEGG: 00626+1.1.1.1|KEGG: 00830+1.1.1.1|KEGG: 00980+1.1.1.1|KEGG: 00982+1.1.1.1|MetaCyc: PWY-3162|MetaCyc: PWY-5057|MetaCyc: PWY-5076|MetaCyc: PWY-5078|MetaCyc: PWY-5079|MetaCyc: PWY-5082|MetaCyc: PWY-5480|MetaCyc: PWY-5486|MetaCyc: PWY-5751|MetaCyc: PWY-6313|MetaCyc: PWY-6333|MetaCyc: PWY-6342|MetaCyc: PWY-6587|MetaCyc: PWY-6802|MetaCyc: PWY-6871|MetaCyc: PWY-7013|MetaCyc: PWY-7111|MetaCyc: PWY-7118|MetaCyc: PWY-7396 SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 58 72 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 Gene3D G3DSA:3.90.180.10 1 165 2.2E-61 T 17-03-2017 IPR011032 GroES-like SHXM_RS22065 22b2d4a59dcf376fe1c416ebef4151e4 329 Gene3D G3DSA:3.40.50.720 166 275 2.0E-11 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46435 52d93a3ca3cb9083864951086985241f 803 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 131 272 2.0E-19 T 17-03-2017 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SHXM_RS46435 52d93a3ca3cb9083864951086985241f 803 Pfam PF14498 Glycosyl hydrolase family 65, N-terminal domain 67 117 3.2E-6 T 17-03-2017 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SHXM_RS46435 52d93a3ca3cb9083864951086985241f 803 PIRSF PIRSF007663 123 801 1.2E-187 T 17-03-2017 IPR016518 Alpha-L-fucosidase GO:0004560 KEGG: 00511+3.2.1.51 SHXM_RS46435 52d93a3ca3cb9083864951086985241f 803 Gene3D G3DSA:2.70.98.50 78 415 1.9E-85 T 17-03-2017 IPR027414 Glycosyl hydrolase family, N-terminal domain KEGG: 00511+3.2.1.51 SHXM_RS46435 52d93a3ca3cb9083864951086985241f 803 SUPERFAMILY SSF48208 284 784 2.18E-56 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS32440 80d3644f3f6a3ae03ba56682ba0f6933 160 TIGRFAM TIGR00581 moaC: molybdenum cofactor biosynthesis protein C 8 154 1.1E-62 T 17-03-2017 IPR023045 Molybdenum cofactor biosynthesis C GO:0006777 Reactome: R-HSA-947581 SHXM_RS32440 80d3644f3f6a3ae03ba56682ba0f6933 160 Gene3D G3DSA:3.30.70.640 7 159 2.7E-65 T 17-03-2017 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 Reactome: R-HSA-947581 SHXM_RS32440 80d3644f3f6a3ae03ba56682ba0f6933 160 Hamap MF_01224_B Cyclic pyranopterin monophosphate synthase accessory protein [moaC]. 6 160 36.339 T 17-03-2017 IPR023046 Molybdenum cofactor biosynthesis C, bacterial-type Reactome: R-HSA-947581 SHXM_RS32440 80d3644f3f6a3ae03ba56682ba0f6933 160 SUPERFAMILY SSF55040 15 157 5.23E-57 T 17-03-2017 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 Reactome: R-HSA-947581 SHXM_RS32440 80d3644f3f6a3ae03ba56682ba0f6933 160 Pfam PF01967 MoaC family 19 152 1.1E-52 T 17-03-2017 IPR002820 Molybdopterin cofactor biosynthesis C (MoaC) domain GO:0006777 Reactome: R-HSA-947581 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 Pfam PF00232 Glycosyl hydrolase family 1 3 462 6.8E-161 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 Gene3D G3DSA:3.20.20.80 4 466 1.4E-161 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 ProSitePatterns PS00572 Glycosyl hydrolases family 1 active site. 368 376 - T 17-03-2017 IPR018120 Glycoside hydrolase family 1, active site SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 PRINTS PR00131 Glycosyl hydrolase family 1 signature 287 301 2.0E-23 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 PRINTS PR00131 Glycosyl hydrolase family 1 signature 389 400 2.0E-23 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 PRINTS PR00131 Glycosyl hydrolase family 1 signature 368 376 2.0E-23 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 PRINTS PR00131 Glycosyl hydrolase family 1 signature 410 427 2.0E-23 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 PRINTS PR00131 Glycosyl hydrolase family 1 signature 434 446 2.0E-23 T 17-03-2017 IPR001360 Glycoside hydrolase family 1 GO:0004553|GO:0005975 SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 ProSitePatterns PS00653 Glycosyl hydrolases family 1 N-terminal signature. 9 23 - T 17-03-2017 IPR033132 Glycosyl hydrolases family 1, N-terminal conserved site SHXM_RS22785 54bdbbeb2a5fc6df3b4a794fa3e2696d 468 SUPERFAMILY SSF51445 3 464 3.37E-162 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS20445 e20350bf4b9924a8de343b689bb2ebea 466 Pfam PF14587 O-Glycosyl hydrolase family 30 36 226 1.0E-10 T 17-03-2017 SHXM_RS20445 e20350bf4b9924a8de343b689bb2ebea 466 SUPERFAMILY SSF51011 368 464 1.55E-7 T 17-03-2017 SHXM_RS20445 e20350bf4b9924a8de343b689bb2ebea 466 Gene3D G3DSA:2.60.40.1180 366 465 2.2E-23 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS20445 e20350bf4b9924a8de343b689bb2ebea 466 Gene3D G3DSA:3.20.20.80 43 365 6.9E-67 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS20445 e20350bf4b9924a8de343b689bb2ebea 466 SUPERFAMILY SSF51445 45 373 2.61E-49 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS20445 e20350bf4b9924a8de343b689bb2ebea 466 Pfam PF17189 Glycosyl hydrolase family 30 beta sandwich domain 372 463 4.4E-9 T 17-03-2017 IPR033452 Glycosyl hydrolase family 30, beta sandwich domain Reactome: R-HSA-1660662|Reactome: R-HSA-390471 SHXM_RS22840 ab16b68c5ba36079f25c5d45b48c81b5 197 SMART SM00855 4 153 4.2E-21 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS22840 ab16b68c5ba36079f25c5d45b48c81b5 197 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 5 193 5.5E-49 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS22840 ab16b68c5ba36079f25c5d45b48c81b5 197 Gene3D G3DSA:3.40.50.1240 1 197 7.2E-47 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS22840 ab16b68c5ba36079f25c5d45b48c81b5 197 SUPERFAMILY SSF53254 1 197 1.01E-47 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS09165 bb800dc29c71042950185ce966ec31ea 179 Gene3D G3DSA:3.90.1150.10 6 46 3.0E-8 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS09165 bb800dc29c71042950185ce966ec31ea 179 SUPERFAMILY SSF53383 4 84 1.35E-16 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS09165 bb800dc29c71042950185ce966ec31ea 179 Pfam PF00202 Aminotransferase class-III 12 84 5.5E-11 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS43415 d6bd86e175283b2a8d45215ccc73a3d8 330 Gene3D G3DSA:3.40.50.10440 11 182 6.5E-71 T 17-03-2017 SHXM_RS43415 d6bd86e175283b2a8d45215ccc73a3d8 330 SUPERFAMILY SSF82549 11 329 3.4E-117 T 17-03-2017 SHXM_RS43415 d6bd86e175283b2a8d45215ccc73a3d8 330 Pfam PF02733 Dak1 domain 17 324 8.6E-125 T 17-03-2017 IPR004006 DhaK domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS43415 d6bd86e175283b2a8d45215ccc73a3d8 330 TIGRFAM TIGR02363 dhaK1: dihydroxyacetone kinase, DhaK subunit 1 325 9.4E-147 T 17-03-2017 IPR012736 Dihydroxyacetone kinase DhaK, subunit 1 SHXM_RS43415 d6bd86e175283b2a8d45215ccc73a3d8 330 Gene3D G3DSA:3.30.1180.20 185 329 1.9E-52 T 17-03-2017 SHXM_RS37450 8c90de999276c45d58b1a789e036e5ec 253 SUPERFAMILY SSF55811 8 171 1.21E-26 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS37450 8c90de999276c45d58b1a789e036e5ec 253 Pfam PF00293 NUDIX domain 15 139 6.9E-18 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS37450 8c90de999276c45d58b1a789e036e5ec 253 ProSitePatterns PS00893 Nudix box signature. 48 69 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS37450 8c90de999276c45d58b1a789e036e5ec 253 Gene3D G3DSA:3.90.79.10 3 164 1.6E-46 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS37450 8c90de999276c45d58b1a789e036e5ec 253 Gene3D G3DSA:1.10.10.10 168 241 5.4E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37450 8c90de999276c45d58b1a789e036e5ec 253 SUPERFAMILY SSF46785 176 246 2.04E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04420 44336792b12afcde3919d3b927795125 219 SUPERFAMILY SSF102198 1 218 2.88E-56 T 17-03-2017 SHXM_RS04420 44336792b12afcde3919d3b927795125 219 Pfam PF04199 Putative cyclase 4 156 6.1E-35 T 17-03-2017 IPR007325 Kynurenine formamidase GO:0004061|GO:0019441 KEGG: 00380+3.5.1.9|KEGG: 00630+3.5.1.9|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-7717|MetaCyc: PWY-7733|MetaCyc: PWY-7734 SHXM_RS04420 44336792b12afcde3919d3b927795125 219 Gene3D G3DSA:3.50.30.50 1 218 5.6E-62 T 17-03-2017 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 Gene3D G3DSA:3.40.50.20 44 150 3.9E-27 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 Hamap MF_01928 N5-carboxyaminoimidazole ribonucleotide synthase [purK]. 45 402 39.882 T 17-03-2017 IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit GO:0004638|GO:0006189 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 Pfam PF02222 ATP-grasp domain 151 323 2.1E-49 T 17-03-2017 IPR003135 ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 SUPERFAMILY SSF56059 142 343 2.12E-60 T 17-03-2017 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 Gene3D G3DSA:3.30.1490.20 155 200 1.6E-4 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 SUPERFAMILY SSF51246 348 417 3.69E-16 T 17-03-2017 IPR011054 Rudiment single hybrid motif Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 TIGRFAM TIGR01161 purK: phosphoribosylaminoimidazole carboxylase, ATPase subunit 46 407 4.8E-115 T 17-03-2017 IPR005875 Phosphoribosylaminoimidazole carboxylase, ATPase subunit GO:0004638|GO:0006189 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 Gene3D G3DSA:3.30.470.20 201 418 2.2E-82 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS24315 c85e40a4997e32cef09d68dd47cd65eb 422 SUPERFAMILY SSF52440 43 137 1.17E-24 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 SMART SM00421 162 219 9.2E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 Pfam PF00196 Bacterial regulatory proteins, luxR family 164 219 5.6E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 179 2.6E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 179 195 2.6E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 195 207 2.6E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 Gene3D G3DSA:1.10.10.10 135 225 7.9E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 SMART SM00448 15 130 1.1E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 SUPERFAMILY SSF52172 14 146 1.39E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 Pfam PF00072 Response regulator receiver domain 17 131 6.3E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 SUPERFAMILY SSF46894 153 225 2.79E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS41995 df2198b589b431221d735e3454f0f95d 228 Gene3D G3DSA:3.40.50.2300 9 134 3.9E-36 T 17-03-2017 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 SUPERFAMILY SSF56645 2 245 2.49E-69 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 119 1.9E-26 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 Gene3D G3DSA:1.10.540.10 4 120 2.8E-30 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 Gene3D G3DSA:2.40.110.10 122 221 9.3E-31 T 17-03-2017 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 SUPERFAMILY SSF47203 232 392 2.09E-25 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 232 385 7.9E-31 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 123 208 1.3E-18 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS43425 9503a58c1b3730be307517a904e742b5 396 Gene3D G3DSA:1.20.140.10 222 393 6.2E-33 T 17-03-2017 SHXM_RS10985 df7ae08c4344400dda6c173eb35abb12 149 Pfam PF03259 Roadblock/LC7 domain 14 103 1.3E-19 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS10985 df7ae08c4344400dda6c173eb35abb12 149 Gene3D G3DSA:3.30.450.30 8 128 1.8E-25 T 17-03-2017 SHXM_RS10985 df7ae08c4344400dda6c173eb35abb12 149 SMART SM00960 13 103 2.6E-24 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS10985 df7ae08c4344400dda6c173eb35abb12 149 SUPERFAMILY SSF103196 8 131 1.92E-28 T 17-03-2017 SHXM_RS14145 3e5d3b549ac4b1b5b45d4de65fa1b77a 473 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 13 378 1.1E-58 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS14145 3e5d3b549ac4b1b5b45d4de65fa1b77a 473 Gene3D G3DSA:3.30.1360.110 300 364 1.0E-7 T 17-03-2017 IPR023116 Phosphonoacetate hydrolase, insert domain GO:0047400 SHXM_RS14145 3e5d3b549ac4b1b5b45d4de65fa1b77a 473 SUPERFAMILY SSF53649 10 385 1.87E-69 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS14145 3e5d3b549ac4b1b5b45d4de65fa1b77a 473 Gene3D G3DSA:3.40.720.10 10 299 1.8E-49 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS03840 f4b422fb9e3784838ae9d15213ed4687 139 SUPERFAMILY SSF54909 1 95 2.5E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS03840 f4b422fb9e3784838ae9d15213ed4687 139 Pfam PF07876 Stress responsive A/B Barrel Domain 6 94 1.9E-11 T 17-03-2017 IPR013097 Stress responsive alpha-beta barrel SHXM_RS03840 f4b422fb9e3784838ae9d15213ed4687 139 SMART SM00886 2 95 3.9E-10 T 17-03-2017 IPR013097 Stress responsive alpha-beta barrel SHXM_RS03840 f4b422fb9e3784838ae9d15213ed4687 139 Gene3D G3DSA:3.30.70.900 1 94 1.7E-14 T 17-03-2017 SHXM_RS41990 40319e3fede83b9b2aeb67ae512a3dcb 269 Gene3D G3DSA:3.40.50.300 19 249 5.3E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41990 40319e3fede83b9b2aeb67ae512a3dcb 269 ProSitePatterns PS00211 ABC transporters family signature. 152 166 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS41990 40319e3fede83b9b2aeb67ae512a3dcb 269 SUPERFAMILY SSF52540 16 237 3.77E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41990 40319e3fede83b9b2aeb67ae512a3dcb 269 SMART SM00382 40 233 1.9E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS41990 40319e3fede83b9b2aeb67ae512a3dcb 269 Pfam PF00005 ABC transporter 32 180 1.6E-33 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS25480 7e933f989f6adbf432c17efd04758e93 460 Pfam PF07730 Histidine kinase 223 286 3.4E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS25480 7e933f989f6adbf432c17efd04758e93 460 SUPERFAMILY SSF55874 309 363 7.36E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25480 7e933f989f6adbf432c17efd04758e93 460 SUPERFAMILY SSF55874 394 451 7.36E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 Pfam PF13411 MerR HTH family regulatory protein 1 67 4.6E-20 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 SUPERFAMILY SSF46955 1 113 2.12E-27 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 SMART SM00422 1 69 9.7E-22 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 Gene3D G3DSA:1.10.1660.10 1 114 1.5E-30 T 17-03-2017 SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 1.3E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 1.3E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS14275 7b986fb2c475a5f46c059eef988a111e 120 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 1.3E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS39510 d6d7d9f2d93f35556117d23a941e9c4e 171 Pfam PF12840 Helix-turn-helix domain 87 136 1.5E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39510 d6d7d9f2d93f35556117d23a941e9c4e 171 SUPERFAMILY SSF46785 76 144 3.02E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39510 d6d7d9f2d93f35556117d23a941e9c4e 171 Gene3D G3DSA:1.10.10.10 72 145 5.2E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SMART SM00065 373 545 5.1E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SUPERFAMILY SSF55785 244 344 9.77E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SUPERFAMILY SSF55781 445 546 3.49E-16 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Gene3D G3DSA:3.30.450.40 365 543 2.4E-37 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SUPERFAMILY SSF103190 73 203 2.31E-32 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Pfam PF17203 Single cache domain 3 71 199 2.8E-23 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Gene3D G3DSA:3.30.450.20 67 205 9.5E-43 T 17-03-2017 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Pfam PF13581 Histidine kinase-like ATPase domain 802 910 2.6E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Gene3D G3DSA:3.30.450.20 248 344 3.3E-5 T 17-03-2017 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SUPERFAMILY SSF55874 834 911 2.01E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 590 789 1.8E-55 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 Pfam PF01590 GAF domain 436 535 3.8E-10 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SMART SM00331 566 789 4.7E-45 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS28585 4cec8e0dfe1bec21685fd7f3ecd02c0f 916 SUPERFAMILY SSF81606 578 788 1.12E-9 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS27585 881335148b0ced389e7629009704d717 108 SMART SM00530 27 82 3.1E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS27585 881335148b0ced389e7629009704d717 108 SUPERFAMILY SSF47413 27 84 4.15E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS27585 881335148b0ced389e7629009704d717 108 Gene3D G3DSA:1.10.260.40 35 88 9.1E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS27585 881335148b0ced389e7629009704d717 108 Pfam PF01381 Helix-turn-helix 34 79 1.6E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS01500 dd203b5b41718289a3808a8333e637b2 333 SUPERFAMILY SSF52283 26 134 2.21E-10 T 17-03-2017 SHXM_RS01500 dd203b5b41718289a3808a8333e637b2 333 Gene3D G3DSA:3.40.50.720 130 295 3.0E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01500 dd203b5b41718289a3808a8333e637b2 333 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 204 226 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS01500 dd203b5b41718289a3808a8333e637b2 333 Gene3D G3DSA:3.40.50.720 26 129 7.8E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01500 dd203b5b41718289a3808a8333e637b2 333 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 121 293 2.3E-41 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS01500 dd203b5b41718289a3808a8333e637b2 333 SUPERFAMILY SSF51735 114 294 1.08E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 287 302 6.3E-14 T 17-03-2017 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 147 162 6.3E-14 T 17-03-2017 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 6.3E-14 T 17-03-2017 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 Gene3D G3DSA:3.50.50.60 273 356 7.7E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 Gene3D G3DSA:3.50.50.60 2 173 7.7E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 Pfam PF01494 FAD binding domain 3 46 2.8E-5 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 Pfam PF01494 FAD binding domain 144 345 2.4E-9 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 SUPERFAMILY SSF51905 3 168 4.63E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44130 b1956bfb985d0dfc2b76c99b0df48abc 377 SUPERFAMILY SSF51905 272 363 4.63E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS21300 6596de526d2e101b5298ced400980fac 240 Pfam PF00753 Metallo-beta-lactamase superfamily 29 216 1.0E-13 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21300 6596de526d2e101b5298ced400980fac 240 SUPERFAMILY SSF56281 7 234 4.48E-39 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21300 6596de526d2e101b5298ced400980fac 240 SMART SM00849 26 216 3.7E-16 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21300 6596de526d2e101b5298ced400980fac 240 Gene3D G3DSA:3.60.15.10 8 235 1.2E-47 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS30130 eba07e22c1e9316761d2f7c74ccdc3ca 270 Gene3D G3DSA:1.10.10.10 123 222 1.1E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30130 eba07e22c1e9316761d2f7c74ccdc3ca 270 SUPERFAMILY SSF46894 126 221 3.21E-30 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS30130 eba07e22c1e9316761d2f7c74ccdc3ca 270 Pfam PF00486 Transcriptional regulatory protein, C terminal 146 219 1.3E-28 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS30130 eba07e22c1e9316761d2f7c74ccdc3ca 270 SMART SM00862 145 219 2.2E-30 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS07555 49c9ec8228eb5a3da129baeb74737777 239 Pfam PF01812 5-formyltetrahydrofolate cyclo-ligase family 24 199 5.6E-24 T 17-03-2017 IPR002698 5-formyltetrahydrofolate cyclo-ligase SHXM_RS07555 49c9ec8228eb5a3da129baeb74737777 239 SUPERFAMILY SSF100950 9 217 2.23E-28 T 17-03-2017 SHXM_RS07555 49c9ec8228eb5a3da129baeb74737777 239 Gene3D G3DSA:3.40.50.10420 9 212 7.9E-28 T 17-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SHXM_RS02600 a53a12ef95003341821873ac937cdae3 389 SUPERFAMILY SSF56059 126 302 2.87E-16 T 17-03-2017 SHXM_RS02600 a53a12ef95003341821873ac937cdae3 389 Gene3D G3DSA:3.30.470.20 129 302 1.3E-8 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS36615 af549bbd69535a54ad3284f0ed7ea626 176 Pfam PF00293 NUDIX domain 18 143 6.7E-20 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS36615 af549bbd69535a54ad3284f0ed7ea626 176 SUPERFAMILY SSF55811 17 148 7.58E-22 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS36615 af549bbd69535a54ad3284f0ed7ea626 176 ProSitePatterns PS00893 Nudix box signature. 54 75 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS36615 af549bbd69535a54ad3284f0ed7ea626 176 PRINTS PR00502 NUDIX hydrolase family signature 49 63 1.0E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS36615 af549bbd69535a54ad3284f0ed7ea626 176 PRINTS PR00502 NUDIX hydrolase family signature 63 78 1.0E-5 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS36615 af549bbd69535a54ad3284f0ed7ea626 176 Gene3D G3DSA:3.90.79.10 15 160 4.2E-29 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS18830 b8dffb994103b0f41e3f7bf0fba1ac8d 376 Pfam PF00877 NlpC/P60 family 277 364 4.5E-24 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS18830 b8dffb994103b0f41e3f7bf0fba1ac8d 376 SUPERFAMILY SSF54001 257 366 1.67E-37 T 17-03-2017 SHXM_RS18830 b8dffb994103b0f41e3f7bf0fba1ac8d 376 Gene3D G3DSA:3.90.1720.10 259 366 1.8E-40 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS12850 5454cbc599f365c5a1023044ba631c0e 388 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 62 378 1.5E-46 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS12850 5454cbc599f365c5a1023044ba631c0e 388 Gene3D G3DSA:3.20.20.190 57 379 8.7E-92 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS12850 5454cbc599f365c5a1023044ba631c0e 388 SUPERFAMILY SSF51695 56 379 6.54E-79 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS28020 79e35c8cf6cced5948cb4c656ab3fedd 238 Gene3D G3DSA:1.10.10.10 4 99 4.1E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28020 79e35c8cf6cced5948cb4c656ab3fedd 238 SUPERFAMILY SSF46785 8 183 8.18E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28020 79e35c8cf6cced5948cb4c656ab3fedd 238 Pfam PF03551 Transcriptional regulator PadR-like family 12 95 5.3E-15 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS19720 c703f318fb3a085248f8b8d04d3bbb86 344 SUPERFAMILY SSF53807 71 337 1.88E-60 T 17-03-2017 SHXM_RS19720 c703f318fb3a085248f8b8d04d3bbb86 344 Gene3D G3DSA:3.40.50.1980 69 186 1.1E-35 T 17-03-2017 SHXM_RS19720 c703f318fb3a085248f8b8d04d3bbb86 344 Gene3D G3DSA:3.40.50.1980 187 343 9.2E-34 T 17-03-2017 SHXM_RS19720 c703f318fb3a085248f8b8d04d3bbb86 344 Pfam PF01497 Periplasmic binding protein 91 316 9.6E-28 T 17-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SHXM_RS07105 f2d5dd920112a615184bee477510739e 256 Pfam PF14023 Protein of unknown function (DUF4239) 48 234 1.7E-22 T 17-03-2017 IPR025333 Protein of unknown function DUF4239 SHXM_RS37405 5a776ec02f0c50e84121e9948c201ad0 208 Pfam PF00440 Bacterial regulatory proteins, tetR family 34 70 1.2E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS37405 5a776ec02f0c50e84121e9948c201ad0 208 Gene3D G3DSA:1.10.10.60 16 64 5.1E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37405 5a776ec02f0c50e84121e9948c201ad0 208 Pfam PF16859 Bacterial transcriptional repressor C-terminal 83 194 2.2E-29 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS37405 5a776ec02f0c50e84121e9948c201ad0 208 SUPERFAMILY SSF46689 17 76 3.39E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS37405 5a776ec02f0c50e84121e9948c201ad0 208 SUPERFAMILY SSF48498 84 203 1.13E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS37405 5a776ec02f0c50e84121e9948c201ad0 208 Gene3D G3DSA:1.10.357.10 66 204 7.5E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 Pfam PF00294 pfkB family carbohydrate kinase 61 357 1.0E-54 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 SUPERFAMILY SSF46785 1 56 1.31E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 Gene3D G3DSA:3.40.1190.20 61 371 7.5E-78 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 Pfam PF13412 Winged helix-turn-helix DNA-binding 4 49 3.6E-6 T 17-03-2017 SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 314 327 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 ProSitePatterns PS00583 pfkB family of carbohydrate kinases signature 1. 95 119 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 Gene3D G3DSA:1.10.10.10 1 58 5.8E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06565 8cbfb2ce95282e05e780610e18a88a0e 378 SUPERFAMILY SSF53613 61 363 5.3E-59 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS01850 b745c7d436caa7866c365e53b06a8eb7 257 TIGRFAM TIGR03084 TIGR03084: TIGR03084 family protein 17 256 2.6E-83 T 17-03-2017 IPR017518 Conserved hypothetical protein CHP03084 SHXM_RS01850 b745c7d436caa7866c365e53b06a8eb7 257 Gene3D G3DSA:1.20.120.450 17 136 1.4E-6 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS01850 b745c7d436caa7866c365e53b06a8eb7 257 Pfam PF08608 Wyosine base formation 190 239 2.3E-10 T 17-03-2017 IPR013917 tRNA wybutosine-synthesis MetaCyc: PWY-7285|MetaCyc: PWY-7286 SHXM_RS01850 b745c7d436caa7866c365e53b06a8eb7 257 SUPERFAMILY SSF109854 16 160 7.32E-28 T 17-03-2017 SHXM_RS01850 b745c7d436caa7866c365e53b06a8eb7 257 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 20 231 5.3E-35 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS01850 b745c7d436caa7866c365e53b06a8eb7 257 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 22 153 3.4E-25 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS12015 6b6644a9b5252cc2dc58b085e5161179 326 Pfam PF02709 N-terminal domain of galactosyltransferase 218 267 1.3E-6 T 17-03-2017 IPR027791 Galactosyltransferase, C-terminal SHXM_RS12015 6b6644a9b5252cc2dc58b085e5161179 326 Pfam PF00535 Glycosyl transferase family 2 64 153 2.3E-14 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS12015 6b6644a9b5252cc2dc58b085e5161179 326 Gene3D G3DSA:3.90.550.10 63 297 6.7E-28 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS12015 6b6644a9b5252cc2dc58b085e5161179 326 SUPERFAMILY SSF53448 219 289 1.53E-36 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS12015 6b6644a9b5252cc2dc58b085e5161179 326 SUPERFAMILY SSF53448 63 172 1.53E-36 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 Pfam PF01037 Lrp/AsnC ligand binding domain 79 139 2.7E-13 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 31 50 5.5E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 4 20 5.5E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 20 31 5.5E-14 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 SUPERFAMILY SSF54909 64 143 3.89E-15 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 Gene3D G3DSA:1.10.10.10 2 55 8.3E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 SMART SM00344 4 111 6.9E-29 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 SUPERFAMILY SSF46785 4 64 6.84E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 Gene3D G3DSA:3.30.70.920 57 142 6.2E-19 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 ProSitePatterns PS00519 AsnC-type HTH domain signature. 22 48 - T 17-03-2017 IPR019885 Transcription regulator HTH, AsnC-type, conserved site SHXM_RS42230 9e8901321052f31be5e5a16308333bff 146 Pfam PF13404 AsnC-type helix-turn-helix domain 5 45 8.0E-15 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS11730 b6218840c5b840de22e423ebbe4da828 301 Gene3D G3DSA:3.90.25.10 181 283 7.4E-16 T 17-03-2017 SHXM_RS11730 b6218840c5b840de22e423ebbe4da828 301 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 220 4.7E-18 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS11730 b6218840c5b840de22e423ebbe4da828 301 SUPERFAMILY SSF51735 1 285 2.46E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11730 b6218840c5b840de22e423ebbe4da828 301 Gene3D G3DSA:3.40.50.720 1 180 1.1E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18560 c0726fd4e49bcd035189cdd456edcef0 265 Pfam PF03799 Cell division protein FtsQ 135 248 1.1E-7 T 17-03-2017 IPR005548 Cell division protein FtsQ/DivIB SHXM_RS18560 c0726fd4e49bcd035189cdd456edcef0 265 Hamap MF_00911 Cell division protein FtsQ [ftsQ]. 32 263 18.911 T 17-03-2017 IPR026579 Cell division protein FtsQ GO:0090529 SHXM_RS18560 c0726fd4e49bcd035189cdd456edcef0 265 Pfam PF08478 POTRA domain, FtsQ-type 63 131 2.0E-17 T 17-03-2017 IPR013685 Polypeptide-transport-associated, FtsQ-type SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 Pfam PF02310 B12 binding domain 15 122 9.6E-21 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 SMART SM00729 180 399 1.1E-8 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 SUPERFAMILY SSF52242 18 118 3.61E-7 T 17-03-2017 IPR006158 Cobalamin (vitamin B12)-binding domain GO:0031419|GO:0046872 Reactome: R-HSA-196741 SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 Gene3D G3DSA:3.20.20.70 36 115 7.3E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 SUPERFAMILY SSF102114 177 336 2.35E-22 T 17-03-2017 SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 Pfam PF04055 Radical SAM superfamily 186 336 1.7E-11 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS15525 801529a5e068df36313cd2fa675e05ff 521 Gene3D G3DSA:3.80.30.20 183 380 2.4E-30 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS00620 c08ca98bfb4c6b53795403d17e214570 298 SUPERFAMILY SSF56112 1 274 2.77E-42 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS00620 c08ca98bfb4c6b53795403d17e214570 298 Pfam PF01636 Phosphotransferase enzyme family 29 255 8.9E-33 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS00620 c08ca98bfb4c6b53795403d17e214570 298 Gene3D G3DSA:3.90.1200.10 101 264 1.0E-30 T 17-03-2017 SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 Gene3D G3DSA:1.20.120.530 97 226 1.1E-30 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 76 5.7E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 SUPERFAMILY SSF46785 7 93 3.23E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 SMART SM00895 99 221 1.1E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 51 67 2.5E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 37 51 2.5E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 Pfam PF07729 FCD domain 99 220 7.1E-27 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 Gene3D G3DSA:1.10.10.10 9 78 1.4E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 SUPERFAMILY SSF48008 97 224 1.28E-28 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS07830 c4856ca2f3993fd6b9e2980071b73d01 236 SMART SM00345 18 77 6.0E-16 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS28235 159eb4020d2c5688b1c91ce1069417f0 496 SUPERFAMILY SSF63817 337 482 1.83E-29 T 17-03-2017 IPR023365 Sortase domain SHXM_RS28235 159eb4020d2c5688b1c91ce1069417f0 496 TIGRFAM TIGR01076 sortase_fam: sortase 343 482 2.6E-14 T 17-03-2017 IPR005754 Sortase family SHXM_RS28235 159eb4020d2c5688b1c91ce1069417f0 496 Pfam PF04203 Sortase family 344 481 5.8E-26 T 17-03-2017 IPR005754 Sortase family SHXM_RS28235 159eb4020d2c5688b1c91ce1069417f0 496 Gene3D G3DSA:2.40.260.10 339 484 3.0E-28 T 17-03-2017 IPR023365 Sortase domain SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 SUPERFAMILY SSF56281 11 243 8.68E-37 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 SMART SM00849 13 180 2.6E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 Pfam PF00753 Metallo-beta-lactamase superfamily 16 170 3.0E-6 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 Pfam PF00581 Rhodanese-like domain 360 444 6.1E-6 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 Gene3D G3DSA:3.40.250.10 359 452 5.4E-17 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 Gene3D G3DSA:3.40.250.10 252 350 5.0E-6 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 SUPERFAMILY SSF52821 220 351 2.23E-13 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 Gene3D G3DSA:3.60.15.10 12 238 1.3E-41 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 SMART SM00450 357 450 1.4E-10 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47465 c463e2cb3cf677910a820aa321b1d5a6 458 SUPERFAMILY SSF52821 340 451 2.62E-21 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS31715 d27d20854adb909cbb2478768dd18685 444 SUPERFAMILY SSF103473 15 434 3.27E-62 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS31715 d27d20854adb909cbb2478768dd18685 444 Gene3D G3DSA:1.20.1250.20 254 436 1.9E-16 T 17-03-2017 SHXM_RS31715 d27d20854adb909cbb2478768dd18685 444 Gene3D G3DSA:1.20.1250.20 30 220 1.2E-26 T 17-03-2017 SHXM_RS31715 d27d20854adb909cbb2478768dd18685 444 Pfam PF07690 Major Facilitator Superfamily 281 434 2.8E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS31715 d27d20854adb909cbb2478768dd18685 444 Pfam PF07690 Major Facilitator Superfamily 39 264 7.7E-23 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS07770 37402c3db4abec12bf1cb46730214587 321 Gene3D G3DSA:1.10.3720.10 29 306 5.5E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07770 37402c3db4abec12bf1cb46730214587 321 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 309 2.5E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07770 37402c3db4abec12bf1cb46730214587 321 SUPERFAMILY SSF161098 81 303 3.66E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36375 9348a8eaabf5b36a0354aca03b4b8d4b 283 SUPERFAMILY SSF53448 14 217 3.18E-27 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS36375 9348a8eaabf5b36a0354aca03b4b8d4b 283 Hamap MF_02114 2-phospho-L-lactate guanylyltransferase [cofC]. 13 217 21.824 T 17-03-2017 IPR002835 2-phospho-L-lactate guanylyltransferase, CofC GO:0016779 KEGG: 00680+2.7.7.68|MetaCyc: PWY-5198 SHXM_RS36375 9348a8eaabf5b36a0354aca03b4b8d4b 283 Pfam PF01983 Guanylyl transferase CofC like 15 216 5.9E-10 T 17-03-2017 IPR002835 2-phospho-L-lactate guanylyltransferase, CofC GO:0016779 KEGG: 00680+2.7.7.68|MetaCyc: PWY-5198 SHXM_RS36375 9348a8eaabf5b36a0354aca03b4b8d4b 283 TIGRFAM TIGR03552 F420_cofC: 2-phospho-L-lactate guanylyltransferase 15 210 2.2E-46 T 17-03-2017 IPR002835 2-phospho-L-lactate guanylyltransferase, CofC GO:0016779 KEGG: 00680+2.7.7.68|MetaCyc: PWY-5198 SHXM_RS36375 9348a8eaabf5b36a0354aca03b4b8d4b 283 Gene3D G3DSA:3.90.550.10 15 182 1.5E-21 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS11845 3016bca805ca684a6c25d39f43a1d984 210 Gene3D G3DSA:1.10.340.30 40 142 4.5E-4 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS11845 3016bca805ca684a6c25d39f43a1d984 210 SUPERFAMILY SSF48150 39 174 2.97E-10 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS46280 7c0ade328967ec1bc38f62a5072c45f5 320 Pfam PF00892 EamA-like transporter family 1 128 4.7E-11 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS46280 7c0ade328967ec1bc38f62a5072c45f5 320 Pfam PF00892 EamA-like transporter family 150 283 6.0E-16 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS46280 7c0ade328967ec1bc38f62a5072c45f5 320 SUPERFAMILY SSF103481 187 286 3.66E-13 T 17-03-2017 SHXM_RS46280 7c0ade328967ec1bc38f62a5072c45f5 320 SUPERFAMILY SSF103481 46 130 1.18E-6 T 17-03-2017 SHXM_RS30955 0ff723cae69afb3877a9f3076b082227 133 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 1 101 18.614 T 17-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SHXM_RS30955 0ff723cae69afb3877a9f3076b082227 133 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 8 97 2.2E-26 T 17-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 SUPERFAMILY SSF54373 287 375 3.66E-11 T 17-03-2017 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 SUPERFAMILY SSF51905 375 430 3.37E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 SUPERFAMILY SSF51905 23 73 3.37E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 SUPERFAMILY SSF51905 125 287 3.37E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 Gene3D G3DSA:3.50.50.60 375 430 2.3E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 Gene3D G3DSA:3.50.50.60 206 286 2.3E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 Gene3D G3DSA:3.50.50.60 127 149 2.3E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 Gene3D G3DSA:3.50.50.60 23 77 2.3E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27255 96a5f52c11f3a917bb106b519314c78c 430 Pfam PF01266 FAD dependent oxidoreductase 24 412 9.7E-61 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS15060 fdd8421343fdd5f96dde1ede751d3158 219 Gene3D G3DSA:3.40.50.850 12 207 4.9E-40 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS15060 fdd8421343fdd5f96dde1ede751d3158 219 SUPERFAMILY SSF52499 11 206 1.31E-44 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS15060 fdd8421343fdd5f96dde1ede751d3158 219 Pfam PF00857 Isochorismatase family 19 168 3.1E-26 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS46950 524588feb6d1488296bbf74b868c3df2 179 Pfam PF01613 Flavin reductase like domain 29 169 1.4E-33 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS46950 524588feb6d1488296bbf74b868c3df2 179 SMART SM00903 29 169 9.0E-47 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS46950 524588feb6d1488296bbf74b868c3df2 179 Gene3D G3DSA:2.30.110.10 23 168 2.1E-47 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS46950 524588feb6d1488296bbf74b868c3df2 179 SUPERFAMILY SSF50475 24 167 4.91E-38 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 SUPERFAMILY SSF46785 12 123 4.89E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 Gene3D G3DSA:3.40.190.10 103 188 4.3E-19 T 17-03-2017 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 52 63 2.2E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 42 2.2E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 52 2.2E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 Gene3D G3DSA:3.40.190.10 189 283 1.3E-26 T 17-03-2017 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 SUPERFAMILY SSF53850 102 314 2.95E-39 T 17-03-2017 SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 Gene3D G3DSA:1.10.10.10 14 94 5.6E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 Pfam PF03466 LysR substrate binding domain 101 309 1.1E-44 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS33545 5d53e77e71bd91beaf87ac36baa1ea17 321 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 17 75 2.9E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS02375 9b67446f428fe50017b69eb476e3d14d 293 ProSitePatterns PS00211 ABC transporters family signature. 169 183 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS02375 9b67446f428fe50017b69eb476e3d14d 293 Pfam PF00005 ABC transporter 48 196 1.8E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS02375 9b67446f428fe50017b69eb476e3d14d 293 Gene3D G3DSA:3.40.50.300 21 270 1.4E-87 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02375 9b67446f428fe50017b69eb476e3d14d 293 SMART SM00382 57 246 5.2E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02375 9b67446f428fe50017b69eb476e3d14d 293 SUPERFAMILY SSF52540 24 268 8.48E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16310 d16329e242a773a8e2841d220165eda5 178 SUPERFAMILY SSF55811 11 172 1.49E-29 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS16310 d16329e242a773a8e2841d220165eda5 178 Pfam PF00293 NUDIX domain 37 153 1.0E-11 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS16310 d16329e242a773a8e2841d220165eda5 178 ProSitePatterns PS00893 Nudix box signature. 74 95 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS16310 d16329e242a773a8e2841d220165eda5 178 PIRSF PIRSF017340 2 174 7.5E-72 T 17-03-2017 IPR024195 NUDIX hydrolase, YfcD, predicted GO:0016817 SHXM_RS16310 d16329e242a773a8e2841d220165eda5 178 Gene3D G3DSA:3.90.79.10 7 172 5.0E-51 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 Pfam PF03466 LysR substrate binding domain 92 194 1.7E-10 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 32 42 3.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 53 3.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 21 32 3.3E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 65 9.8E-22 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 SUPERFAMILY SSF46785 5 86 1.15E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 Gene3D G3DSA:1.10.10.10 4 83 3.4E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 SUPERFAMILY SSF53850 93 277 6.38E-18 T 17-03-2017 SHXM_RS33740 b446d1c150d1bf4dc87457e2748e2af2 296 Gene3D G3DSA:3.40.190.10 94 189 2.7E-9 T 17-03-2017 SHXM_RS45845 e43ea7c73413725a2b29cb25d41f0cf7 424 Pfam PF04932 O-Antigen ligase 208 338 7.2E-10 T 17-03-2017 IPR007016 O-antigen ligase-related SHXM_RS07740 0fba6f8d201703c580b6a119a78a54e8 476 Gene3D G3DSA:3.40.190.10 185 359 7.2E-23 T 17-03-2017 SHXM_RS07740 0fba6f8d201703c580b6a119a78a54e8 476 Pfam PF01547 Bacterial extracellular solute-binding protein 79 370 6.6E-39 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS07740 0fba6f8d201703c580b6a119a78a54e8 476 SUPERFAMILY SSF53850 57 464 1.04E-70 T 17-03-2017 SHXM_RS07740 0fba6f8d201703c580b6a119a78a54e8 476 Gene3D G3DSA:3.40.190.10 360 404 3.3E-30 T 17-03-2017 SHXM_RS07740 0fba6f8d201703c580b6a119a78a54e8 476 Gene3D G3DSA:3.40.190.10 16 161 3.3E-30 T 17-03-2017 SHXM_RS50875 944ad574e90c9dece4a0db0836a27343 268 Pfam PF05621 Bacterial TniB protein 20 249 5.2E-7 T 17-03-2017 IPR008868 Bacterial TniB SHXM_RS50875 944ad574e90c9dece4a0db0836a27343 268 SUPERFAMILY SSF52540 20 252 7.97E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27450 a03a52680170f6f8aca9210c9fbae761 204 Gene3D G3DSA:1.10.357.10 58 202 4.4E-14 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS27450 a03a52680170f6f8aca9210c9fbae761 204 SUPERFAMILY SSF46689 4 84 4.51E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS27450 a03a52680170f6f8aca9210c9fbae761 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 1.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27450 a03a52680170f6f8aca9210c9fbae761 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 1.6E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27450 a03a52680170f6f8aca9210c9fbae761 204 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 59 2.8E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27450 a03a52680170f6f8aca9210c9fbae761 204 Gene3D G3DSA:1.10.10.60 7 57 3.4E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 SUPERFAMILY SSF52540 19 267 3.88E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 Pfam PF00005 ABC transporter 45 196 1.2E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 ProSitePatterns PS00211 ABC transporters family signature. 168 182 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 248 312 2.7E-16 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 SMART SM00382 53 245 3.2E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 Gene3D G3DSA:3.40.50.300 17 269 2.0E-78 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12095 0f8562a6de7e9f94f0ba866dacad2424 335 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 245 332 4.5E-26 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS11505 80c6bdedcd9bc88b993e1823b177c450 542 Gene3D G3DSA:3.40.50.300 283 507 1.6E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11505 80c6bdedcd9bc88b993e1823b177c450 542 SUPERFAMILY SSF52540 280 510 3.01E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 Pfam PF01037 Lrp/AsnC ligand binding domain 74 144 5.8E-15 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 Pfam PF13404 AsnC-type helix-turn-helix domain 9 49 1.3E-16 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 Gene3D G3DSA:1.10.10.10 8 58 1.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 Gene3D G3DSA:3.30.70.920 62 140 2.8E-19 T 17-03-2017 IPR019887 Transcription regulator AsnC/Lrp, ligand binding domain SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 SUPERFAMILY SSF54909 69 147 5.23E-15 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 SUPERFAMILY SSF46785 8 68 6.71E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 24 35 2.7E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 8 24 2.7E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 PRINTS PR00033 AsnC bacterial regulatory protein HTH signature 35 54 2.7E-10 T 17-03-2017 IPR000485 AsnC-type HTH domain GO:0006355|GO:0043565 SHXM_RS06645 ce777168b93b4f2e46828c43c46e24c4 163 SMART SM00344 8 115 7.2E-33 T 17-03-2017 IPR019888 Transcription regulator AsnC-type GO:0003700|GO:0005622|GO:0006355|GO:0043565 SHXM_RS04695 2c564b6b21e012ee427a205f128a5f15 259 Gene3D G3DSA:3.40.50.300 2 216 1.7E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04695 2c564b6b21e012ee427a205f128a5f15 259 SMART SM00382 33 214 2.5E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS04695 2c564b6b21e012ee427a205f128a5f15 259 SUPERFAMILY SSF52540 5 231 1.25E-70 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04695 2c564b6b21e012ee427a205f128a5f15 259 Pfam PF00005 ABC transporter 25 163 2.3E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS07805 48345718b4695d436882a7248a531394 623 Pfam PF00271 Helicase conserved C-terminal domain 233 340 6.4E-15 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS07805 48345718b4695d436882a7248a531394 623 SMART SM00487 30 224 2.2E-28 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS07805 48345718b4695d436882a7248a531394 623 TIGRFAM TIGR00614 recQ_fam: ATP-dependent DNA helicase, RecQ family 24 475 1.4E-151 T 17-03-2017 IPR004589 DNA helicase, ATP-dependent, RecQ type GO:0006310|GO:0008026 SHXM_RS07805 48345718b4695d436882a7248a531394 623 SUPERFAMILY SSF52540 216 472 1.35E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07805 48345718b4695d436882a7248a531394 623 SMART SM00490 259 340 4.9E-23 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS07805 48345718b4695d436882a7248a531394 623 Gene3D G3DSA:3.40.50.300 23 212 1.5E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07805 48345718b4695d436882a7248a531394 623 Pfam PF00270 DEAD/DEAH box helicase 38 194 5.7E-17 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS07805 48345718b4695d436882a7248a531394 623 Pfam PF09382 RQC domain 415 528 1.6E-32 T 17-03-2017 IPR018982 RQC domain GO:0006260|GO:0006281|GO:0043140 Reactome: R-HSA-3108214|Reactome: R-HSA-5685938|Reactome: R-HSA-5685942|Reactome: R-HSA-5693554|Reactome: R-HSA-5693568|Reactome: R-HSA-5693579|Reactome: R-HSA-5693607|Reactome: R-HSA-5693616|Reactome: R-HSA-6804756|Reactome: R-HSA-69473 SHXM_RS07805 48345718b4695d436882a7248a531394 623 Gene3D G3DSA:3.40.50.300 215 353 9.6E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07805 48345718b4695d436882a7248a531394 623 Pfam PF16124 RecQ zinc-binding 352 413 3.2E-16 T 17-03-2017 IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domain SHXM_RS07805 48345718b4695d436882a7248a531394 623 SMART SM00341 551 620 8.5E-11 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS07805 48345718b4695d436882a7248a531394 623 Gene3D G3DSA:1.10.10.10 354 529 1.7E-51 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07805 48345718b4695d436882a7248a531394 623 SUPERFAMILY SSF47819 548 622 1.46E-21 T 17-03-2017 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 SHXM_RS07805 48345718b4695d436882a7248a531394 623 TIGRFAM TIGR01389 recQ: ATP-dependent DNA helicase RecQ 24 620 2.6E-231 T 17-03-2017 IPR006293 DNA helicase, ATP-dependent, RecQ type, bacterial GO:0004003|GO:0006310|GO:0009432 SHXM_RS07805 48345718b4695d436882a7248a531394 623 Gene3D G3DSA:1.10.150.80 557 622 5.3E-18 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS07805 48345718b4695d436882a7248a531394 623 SUPERFAMILY SSF52540 22 206 4.57E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07805 48345718b4695d436882a7248a531394 623 Pfam PF00570 HRDC domain 557 620 2.9E-22 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS07805 48345718b4695d436882a7248a531394 623 SMART SM00956 420 526 1.8E-41 T 17-03-2017 IPR018982 RQC domain GO:0006260|GO:0006281|GO:0043140 Reactome: R-HSA-3108214|Reactome: R-HSA-5685938|Reactome: R-HSA-5685942|Reactome: R-HSA-5693554|Reactome: R-HSA-5693568|Reactome: R-HSA-5693579|Reactome: R-HSA-5693607|Reactome: R-HSA-5693616|Reactome: R-HSA-6804756|Reactome: R-HSA-69473 SHXM_RS05790 c9d7e9d6efeebf82d91aa396d4cf9373 1070 TIGRFAM TIGR02243 TIGR02243: putative baseplate assembly protein 657 1007 2.3E-62 T 17-03-2017 IPR011749 Conserved hypothetical protein CHP02243 SHXM_RS05790 c9d7e9d6efeebf82d91aa396d4cf9373 1070 Pfam PF04865 Baseplate J-like protein 830 955 2.9E-5 T 17-03-2017 IPR006949 Baseplate protein J-like SHXM_RS32855 1322fc57f839626f49a983e632587e3d 262 SMART SM00382 49 235 1.8E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32855 1322fc57f839626f49a983e632587e3d 262 Gene3D G3DSA:3.40.50.300 23 239 2.1E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32855 1322fc57f839626f49a983e632587e3d 262 SUPERFAMILY SSF52540 23 239 1.23E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32855 1322fc57f839626f49a983e632587e3d 262 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS32855 1322fc57f839626f49a983e632587e3d 262 Pfam PF00005 ABC transporter 40 186 2.9E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS34450 89ba307e9150335bde47b91e7ebab46d 272 Pfam PF02586 SOS response associated peptidase (SRAP) 1 251 3.8E-67 T 17-03-2017 IPR003738 SOS response associated peptidase (SRAP) SHXM_RS34450 89ba307e9150335bde47b91e7ebab46d 272 SUPERFAMILY SSF143081 2 262 7.72E-63 T 17-03-2017 IPR003738 SOS response associated peptidase (SRAP) SHXM_RS34450 89ba307e9150335bde47b91e7ebab46d 272 Gene3D G3DSA:3.90.1680.10 1 262 8.3E-74 T 17-03-2017 IPR003738 SOS response associated peptidase (SRAP) SHXM_RS30885 f9d370dba0e324973d31ba9e01e4f2f2 376 TIGRFAM TIGR00688 rarD: protein RarD 13 265 5.6E-62 T 17-03-2017 IPR004626 RarD protein GO:0005215|GO:0005887|GO:0006810 SHXM_RS30885 f9d370dba0e324973d31ba9e01e4f2f2 376 SUPERFAMILY SSF103481 196 291 1.29E-9 T 17-03-2017 SHXM_RS30885 f9d370dba0e324973d31ba9e01e4f2f2 376 SUPERFAMILY SSF103481 52 151 1.16E-12 T 17-03-2017 SHXM_RS30885 f9d370dba0e324973d31ba9e01e4f2f2 376 Pfam PF00892 EamA-like transporter family 158 289 2.6E-6 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS30885 f9d370dba0e324973d31ba9e01e4f2f2 376 Pfam PF00892 EamA-like transporter family 14 149 3.7E-13 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS27020 db5f774360aac53a04d720dc5881ea4b 325 Pfam PF02374 Anion-transporting ATPase 6 178 3.5E-18 T 17-03-2017 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 SHXM_RS27020 db5f774360aac53a04d720dc5881ea4b 325 SUPERFAMILY SSF52540 4 225 1.14E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27020 db5f774360aac53a04d720dc5881ea4b 325 Gene3D G3DSA:3.40.50.300 6 234 3.4E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42730 c85852db0474d57ac0b78da9c86f9c10 350 Gene3D G3DSA:3.30.420.40 245 314 7.6E-8 T 17-03-2017 SHXM_RS42730 c85852db0474d57ac0b78da9c86f9c10 350 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 169 315 9.3E-13 T 17-03-2017 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 SHXM_RS42730 c85852db0474d57ac0b78da9c86f9c10 350 SUPERFAMILY SSF53067 167 333 2.12E-38 T 17-03-2017 SHXM_RS42730 c85852db0474d57ac0b78da9c86f9c10 350 SUPERFAMILY SSF53067 104 120 2.12E-38 T 17-03-2017 SHXM_RS49565 07886137b90d5edce93058275a24e1ac 433 SUPERFAMILY SSF53067 96 206 1.31E-11 T 17-03-2017 SHXM_RS49565 07886137b90d5edce93058275a24e1ac 433 Pfam PF01869 BadF/BadG/BcrA/BcrD ATPase family 99 382 1.0E-10 T 17-03-2017 IPR002731 ATPase, BadF/BadG/BcrA/BcrD type Reactome: R-HSA-446210 SHXM_RS49565 07886137b90d5edce93058275a24e1ac 433 SUPERFAMILY SSF53067 215 402 2.51E-18 T 17-03-2017 SHXM_RS49565 07886137b90d5edce93058275a24e1ac 433 Gene3D G3DSA:3.30.420.40 93 171 2.5E-4 T 17-03-2017 SHXM_RS18770 839f850c24aa1949e337db07fc8de0db 241 Gene3D G3DSA:3.40.1130.10 13 203 5.1E-31 T 17-03-2017 SHXM_RS18770 839f850c24aa1949e337db07fc8de0db 241 Pfam PF01553 Acyltransferase 17 147 4.8E-21 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS18770 839f850c24aa1949e337db07fc8de0db 241 SUPERFAMILY SSF69593 10 218 2.62E-50 T 17-03-2017 SHXM_RS18770 839f850c24aa1949e337db07fc8de0db 241 SMART SM00563 29 150 4.6E-34 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 Hamap MF_00377 Chromosomal replication initiator protein DnaA [dnaA]. 9 609 33.278 T 17-03-2017 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 SMART SM00382 304 432 2.3E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS28120 79f27d445543be549a18c2652165d160 611 SMART SM00760 518 587 1.9E-34 T 17-03-2017 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 SUPERFAMILY SSF52540 271 483 9.21E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28120 79f27d445543be549a18c2652165d160 611 Gene3D G3DSA:1.10.8.60 438 507 1.9E-28 T 17-03-2017 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 Pfam PF00308 Bacterial dnaA protein 272 489 1.0E-103 T 17-03-2017 IPR013317 Chromosomal replication initiator protein DnaA SHXM_RS28120 79f27d445543be549a18c2652165d160 611 Gene3D G3DSA:1.10.1750.10 513 610 7.5E-38 T 17-03-2017 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 Gene3D G3DSA:3.40.50.300 269 436 1.1E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28120 79f27d445543be549a18c2652165d160 611 SUPERFAMILY SSF48295 515 610 1.15E-33 T 17-03-2017 IPR010921 Trp repressor/replication initiator GO:0043565 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 ProSitePatterns PS01008 DnaA protein signature. 568 587 - T 17-03-2017 IPR018312 Chromosomal replication control, initiator DnaA, conserved site GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 TIGRFAM TIGR00362 DnaA: chromosomal replication initiator protein DnaA 36 608 3.8E-154 T 17-03-2017 IPR001957 Chromosomal replication control, initiator DnaA GO:0003677|GO:0003688|GO:0005524|GO:0006270|GO:0006275 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 Pfam PF08299 Bacterial dnaA protein helix-turn-helix 521 587 4.2E-29 T 17-03-2017 IPR013159 Chromosomal replication initiator, DnaA C-terminal GO:0005524|GO:0006270|GO:0006275|GO:0043565 SHXM_RS28120 79f27d445543be549a18c2652165d160 611 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 403 430 5.3E-52 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS28120 79f27d445543be549a18c2652165d160 611 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 568 587 5.3E-52 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS28120 79f27d445543be549a18c2652165d160 611 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 369 383 5.3E-52 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS28120 79f27d445543be549a18c2652165d160 611 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 305 325 5.3E-52 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS28120 79f27d445543be549a18c2652165d160 611 PRINTS PR00051 Bacterial chromosomal replication initiator (DNAA) signature 337 351 5.3E-52 T 17-03-2017 IPR020591 Chromosomal replication control, initiator DnaA-like SHXM_RS33380 5527cc7cdff19f6af28a574fb158c87b 490 PIRSF PIRSF002746 23 490 1.5E-164 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS33380 5527cc7cdff19f6af28a574fb158c87b 490 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 29 490 4.1E-118 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS33380 5527cc7cdff19f6af28a574fb158c87b 490 Pfam PF02447 GntP family permease 29 489 1.0E-130 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS42500 c791a64f8bc0880a71a1177ca4ff955c 437 Gene3D G3DSA:3.40.640.10 61 323 2.4E-69 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS42500 c791a64f8bc0880a71a1177ca4ff955c 437 Gene3D G3DSA:3.90.1150.10 11 60 6.6E-27 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS42500 c791a64f8bc0880a71a1177ca4ff955c 437 Gene3D G3DSA:3.90.1150.10 326 432 6.6E-27 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS42500 c791a64f8bc0880a71a1177ca4ff955c 437 SUPERFAMILY SSF53383 17 432 1.85E-105 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS42500 c791a64f8bc0880a71a1177ca4ff955c 437 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 240 277 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS42500 c791a64f8bc0880a71a1177ca4ff955c 437 Pfam PF00202 Aminotransferase class-III 26 430 2.0E-82 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS28455 d76269379f8c4c0633a12cbdc3b0e1c6 431 Gene3D G3DSA:1.20.1250.20 231 416 9.1E-12 T 17-03-2017 SHXM_RS28455 d76269379f8c4c0633a12cbdc3b0e1c6 431 SUPERFAMILY SSF103473 10 416 5.1E-53 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS28455 d76269379f8c4c0633a12cbdc3b0e1c6 431 Gene3D G3DSA:1.20.1250.20 23 199 1.2E-26 T 17-03-2017 SHXM_RS28455 d76269379f8c4c0633a12cbdc3b0e1c6 431 Pfam PF07690 Major Facilitator Superfamily 26 368 4.9E-30 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS11105 e8ad8b28bd409faede970eb792abf310 265 SUPERFAMILY SSF53335 16 246 3.04E-42 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11105 e8ad8b28bd409faede970eb792abf310 265 PIRSF PIRSF017393 1 264 5.1E-102 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS11105 e8ad8b28bd409faede970eb792abf310 265 Gene3D G3DSA:3.40.50.150 5 263 7.1E-105 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11105 e8ad8b28bd409faede970eb792abf310 265 Pfam PF04672 S-adenosyl methyltransferase 8 263 5.1E-100 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 Pfam PF04101 Glycosyltransferase family 28 C-terminal domain 188 348 3.5E-39 T 17-03-2017 IPR007235 Glycosyl transferase, family 28, C-terminal GO:0016758 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-5633231 SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 TIGRFAM TIGR01133 murG: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 2 351 1.1E-87 T 17-03-2017 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 3 142 5.4E-43 T 17-03-2017 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 Gene3D G3DSA:3.40.50.2000 192 328 7.8E-4 T 17-03-2017 SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 Gene3D G3DSA:3.40.50.2000 2 191 1.0E-61 T 17-03-2017 SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 Hamap MF_00033 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [murG]. 3 358 31.788 T 17-03-2017 IPR006009 N-acetylglucosaminyltransferase, MurG GO:0009252|GO:0050511 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18565 43975c3435662d8117d8bc6c48219fab 364 SUPERFAMILY SSF53756 2 358 1.04E-100 T 17-03-2017 SHXM_RS30760 eee6119f378df3bb5f93ca1fc7b31fc8 184 Gene3D G3DSA:3.40.50.700 24 152 1.4E-33 T 17-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30760 eee6119f378df3bb5f93ca1fc7b31fc8 184 SUPERFAMILY SSF56770 9 154 1.83E-64 T 17-03-2017 SHXM_RS30760 eee6119f378df3bb5f93ca1fc7b31fc8 184 TIGRFAM TIGR01957 nuoB_fam: NADH-quinone oxidoreductase, B subunit 11 153 7.9E-69 T 17-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30760 eee6119f378df3bb5f93ca1fc7b31fc8 184 Pfam PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit 37 145 2.9E-24 T 17-03-2017 IPR006137 NADH:ubiquinone oxidoreductase-like, 20kDa subunit GO:0051536|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30760 eee6119f378df3bb5f93ca1fc7b31fc8 184 Hamap MF_01356 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic [ndhK]. 1 151 41.619 T 17-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30760 eee6119f378df3bb5f93ca1fc7b31fc8 184 ProSitePatterns PS01150 Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. 118 134 - T 17-03-2017 IPR006138 NADH-ubiquinone oxidoreductase, 20 Kd subunit GO:0008137|GO:0048038|GO:0051539|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 342 440 6.2E-13 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 106 280 1.3E-26 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 Gene3D G3DSA:3.10.105.10 351 431 5.7E-59 T 17-03-2017 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 Gene3D G3DSA:3.10.105.10 532 676 5.7E-59 T 17-03-2017 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 Gene3D G3DSA:3.40.190.10 183 285 7.8E-15 T 17-03-2017 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 Gene3D G3DSA:3.90.76.10 88 182 1.1E-11 T 17-03-2017 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 SUPERFAMILY SSF53850 52 281 8.15E-69 T 17-03-2017 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 SUPERFAMILY SSF53850 335 431 8.15E-69 T 17-03-2017 SHXM_RS33835 eb77efcb94f6d86ce3dba85e95fa35a5 705 SUPERFAMILY SSF53850 532 700 8.15E-69 T 17-03-2017 SHXM_RS03510 1087532f6f64ae96d0d748b1795c2464 316 Pfam PF13743 Thioredoxin 24 180 3.9E-8 T 17-03-2017 SHXM_RS03510 1087532f6f64ae96d0d748b1795c2464 316 Gene3D G3DSA:1.10.472.60 89 182 2.1E-5 T 17-03-2017 IPR023169 UPF0413, central domain SHXM_RS03510 1087532f6f64ae96d0d748b1795c2464 316 Gene3D G3DSA:3.40.30.10 18 88 3.7E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS03510 1087532f6f64ae96d0d748b1795c2464 316 SUPERFAMILY SSF52833 19 182 6.07E-14 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS34245 bc5005519aa8b2f6a250be5a94999a1b 255 Pfam PF12138 Spherulation-specific family 4 24 247 2.9E-17 T 17-03-2017 IPR021986 Spherulation-specific family 4 SHXM_RS49835 c029fcebf2f9410fc80b97abbaa1c018 292 Pfam PF01418 Helix-turn-helix domain, rpiR family 18 88 8.8E-15 T 17-03-2017 IPR000281 Helix-turn-helix protein RpiR GO:0003700|GO:0006355 SHXM_RS49835 c029fcebf2f9410fc80b97abbaa1c018 292 Pfam PF01380 SIS domain 140 265 1.3E-15 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS49835 c029fcebf2f9410fc80b97abbaa1c018 292 SUPERFAMILY SSF46689 17 88 1.63E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49835 c029fcebf2f9410fc80b97abbaa1c018 292 Gene3D G3DSA:1.10.10.10 17 78 5.3E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49835 c029fcebf2f9410fc80b97abbaa1c018 292 SUPERFAMILY SSF53697 106 283 8.9E-36 T 17-03-2017 SHXM_RS49835 c029fcebf2f9410fc80b97abbaa1c018 292 Gene3D G3DSA:3.40.50.10490 79 271 1.9E-32 T 17-03-2017 SHXM_RS15970 02843b84d75e24908360d149ecb49aa1 532 Gene3D G3DSA:3.10.105.10 288 500 7.0E-43 T 17-03-2017 SHXM_RS15970 02843b84d75e24908360d149ecb49aa1 532 Gene3D G3DSA:3.90.76.10 50 203 7.2E-32 T 17-03-2017 SHXM_RS15970 02843b84d75e24908360d149ecb49aa1 532 SUPERFAMILY SSF53850 48 527 2.25E-95 T 17-03-2017 SHXM_RS15970 02843b84d75e24908360d149ecb49aa1 532 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 83 450 1.3E-70 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS15970 02843b84d75e24908360d149ecb49aa1 532 PIRSF PIRSF002741 1 526 1.6E-73 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS07390 8ec8697130a7027546ef3ff07615752a 776 SUPERFAMILY SSF48208 262 709 8.33E-46 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS07390 8ec8697130a7027546ef3ff07615752a 776 Gene3D G3DSA:1.50.10.10 428 624 1.9E-12 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 SUPERFAMILY SSF53474 6 382 2.48E-90 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 Gene3D G3DSA:3.40.50.1820 4 387 1.1E-129 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 Pfam PF06441 Epoxide hydrolase N terminus 8 120 3.7E-31 T 17-03-2017 IPR010497 Epoxide hydrolase, N-terminal KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 PRINTS PR00412 Epoxide hydrolase signature 327 343 4.5E-11 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 PRINTS PR00412 Epoxide hydrolase signature 137 152 4.5E-11 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 PRINTS PR00412 Epoxide hydrolase signature 359 381 4.5E-11 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 PRINTS PR00412 Epoxide hydrolase signature 182 195 4.5E-11 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 PRINTS PR00412 Epoxide hydrolase signature 111 129 4.5E-11 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS28955 edd19a10c932f9f326f266154e6b6103 390 PIRSF PIRSF001112 2 387 5.5E-106 T 17-03-2017 IPR016292 Epoxide hydrolase GO:0033961 KEGG: 00980+3.3.2.9|Reactome: R-HSA-211945 SHXM_RS24580 f9f39dbf8753d57be1eab8485d9c18e4 123 Pfam PF05331 Protein of unknown function (DUF742) 11 120 4.2E-34 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS24580 f9f39dbf8753d57be1eab8485d9c18e4 123 Gene3D G3DSA:1.10.10.10 48 86 3.5E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24580 f9f39dbf8753d57be1eab8485d9c18e4 123 SUPERFAMILY SSF88659 46 86 6.08E-5 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 Gene3D G3DSA:3.30.43.10 1 49 1.1E-12 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 4 217 4.3E-47 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 Gene3D G3DSA:3.30.390.50 222 322 1.4E-28 T 17-03-2017 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 Gene3D G3DSA:3.30.465.10 155 217 1.7E-34 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 Gene3D G3DSA:3.30.465.10 54 110 1.7E-34 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 SUPERFAMILY SSF55447 222 324 9.16E-24 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 226 322 2.5E-15 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 SUPERFAMILY SSF56176 1 217 5.45E-55 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS47990 417df6fbf33e01be8c1df701d7e46665 328 SMART SM01092 224 323 3.7E-23 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 Gene3D G3DSA:1.10.150.20 178 246 2.5E-20 T 17-03-2017 SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 Pfam PF02739 5'-3' exonuclease, N-terminal resolvase-like domain 1 179 1.1E-47 T 17-03-2017 IPR020046 5'-3' exonuclease, alpha-helical arch, N-terminal GO:0003677 SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 SMART SM00475 1 274 4.6E-79 T 17-03-2017 IPR002421 5'-3' exonuclease, N-terminal GO:0003677 SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 SUPERFAMILY SSF88723 1 162 3.24E-37 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 SUPERFAMILY SSF47807 184 296 7.03E-20 T 17-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 SMART SM00279 182 217 6.4E-11 T 17-03-2017 IPR008918 Helix-hairpin-helix motif, class 2 GO:0003677|GO:0003824 SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 Pfam PF01367 5'-3' exonuclease, C-terminal SAM fold 183 265 5.9E-18 T 17-03-2017 IPR020045 5'-3' exonuclease, C-terminal domain GO:0003677|GO:0003824 SHXM_RS15830 1faeeebb3f1e3d1def3f069969eceb4d 303 Gene3D G3DSA:3.40.50.1010 1 177 2.7E-48 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS15450 90b1fcf378b2cee43af8b4a2ece4f282 123 SUPERFAMILY SSF50324 26 83 1.83E-8 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS15450 90b1fcf378b2cee43af8b4a2ece4f282 123 Gene3D G3DSA:3.90.80.10 26 68 7.9E-6 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS32185 cd1b269c3f263bfe690499ec1ef25a0c 357 Pfam PF00589 Phage integrase family 162 339 4.4E-28 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS32185 cd1b269c3f263bfe690499ec1ef25a0c 357 SUPERFAMILY SSF56349 49 346 9.71E-70 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS32185 cd1b269c3f263bfe690499ec1ef25a0c 357 Gene3D G3DSA:1.10.150.130 49 149 8.1E-19 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS32185 cd1b269c3f263bfe690499ec1ef25a0c 357 Pfam PF14659 Phage integrase, N-terminal SAM-like domain 49 103 1.3E-7 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS32185 cd1b269c3f263bfe690499ec1ef25a0c 357 Gene3D G3DSA:1.10.443.10 154 346 5.3E-46 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS14045 5d7b94f7982fcf5baae305cf2a7e1c23 450 SUPERFAMILY SSF51338 4 58 4.44E-27 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14045 5d7b94f7982fcf5baae305cf2a7e1c23 450 SUPERFAMILY SSF51338 362 436 4.44E-27 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS14045 5d7b94f7982fcf5baae305cf2a7e1c23 450 SUPERFAMILY SSF51556 58 363 5.11E-61 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS14045 5d7b94f7982fcf5baae305cf2a7e1c23 450 Pfam PF01979 Amidohydrolase family 55 410 4.1E-32 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS14045 5d7b94f7982fcf5baae305cf2a7e1c23 450 Gene3D G3DSA:3.20.20.140 68 380 4.4E-61 T 17-03-2017 SHXM_RS14045 5d7b94f7982fcf5baae305cf2a7e1c23 450 Gene3D G3DSA:2.30.40.10 4 67 2.0E-20 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 Hamap MF_00607 Ribosomal RNA small subunit methyltransferase A [rsmA]. 24 286 48.704 T 17-03-2017 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 TIGRFAM TIGR00755 ksgA: ribosomal RNA small subunit methyltransferase A 24 283 1.6E-71 T 17-03-2017 IPR011530 Ribosomal RNA adenine dimethylase GO:0000179|GO:0006364 SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 SMART SM00650 40 214 6.1E-70 T 17-03-2017 IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal GO:0000154|GO:0000179|GO:0008649 SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 ProSitePatterns PS01131 Ribosomal RNA adenine dimethylases signature. 56 83 - T 17-03-2017 IPR020596 Ribosomal RNA adenine methylase transferase, conserved site GO:0000154|GO:0000179|GO:0008649 SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 SUPERFAMILY SSF53335 23 283 1.33E-63 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 Gene3D G3DSA:1.10.8.100 222 283 2.3E-21 T 17-03-2017 IPR023165 rRNA adenine dimethylase-like Reactome: R-HSA-2151201 SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 Pfam PF00398 Ribosomal RNA adenine dimethylase 28 282 2.7E-42 T 17-03-2017 IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm SHXM_RS32680 827317715ba606fece02571f5ff1b39b 288 Gene3D G3DSA:3.40.50.150 12 215 1.7E-67 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 Gene3D G3DSA:3.30.300.30 447 529 2.5E-4 T 17-03-2017 SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 ProSitePatterns PS00455 Putative AMP-binding domain signature. 181 192 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 Gene3D G3DSA:3.40.50.980 34 187 4.7E-18 T 17-03-2017 SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 Pfam PF00501 AMP-binding enzyme 30 440 3.3E-45 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 Gene3D G3DSA:3.40.50.980 188 321 3.4E-12 T 17-03-2017 SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 Gene3D G3DSA:2.30.38.10 366 435 2.6E-11 T 17-03-2017 SHXM_RS16450 e68dcccb7513ccb00184a13d8360c077 539 SUPERFAMILY SSF56801 11 528 3.53E-62 T 17-03-2017 SHXM_RS03640 3983ec3973cebc96c277fb9d9c531fe4 148 TIGRFAM TIGR00026 hi_GC_TIGR00026: deazaflavin-dependent oxidoreductase, nitroreductase family 31 142 2.1E-37 T 17-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 SHXM_RS03640 3983ec3973cebc96c277fb9d9c531fe4 148 SUPERFAMILY SSF50475 34 144 5.69E-5 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS03640 3983ec3973cebc96c277fb9d9c531fe4 148 Pfam PF04075 Domain of unknown function (DUF385) 15 143 2.8E-54 T 17-03-2017 IPR004378 Deazaflavin-dependent nitroreductase/F420H(2)-dependent quinone reductase GO:0016491|GO:0055114 SHXM_RS07050 e347e3cb1c908fa1a9081757a7c11f0f 281 Pfam PF13409 Glutathione S-transferase, N-terminal domain 62 139 6.5E-6 T 17-03-2017 IPR004045 Glutathione S-transferase, N-terminal GO:0005515 SHXM_RS07050 e347e3cb1c908fa1a9081757a7c11f0f 281 SUPERFAMILY SSF47616 160 274 5.43E-16 T 17-03-2017 IPR010987 Glutathione S-transferase, C-terminal-like SHXM_RS07050 e347e3cb1c908fa1a9081757a7c11f0f 281 Gene3D G3DSA:3.40.30.10 44 144 2.3E-6 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS07050 e347e3cb1c908fa1a9081757a7c11f0f 281 Pfam PF13410 Glutathione S-transferase, C-terminal domain 190 261 4.4E-9 T 17-03-2017 SHXM_RS07050 e347e3cb1c908fa1a9081757a7c11f0f 281 Gene3D G3DSA:1.20.1050.10 159 264 8.9E-13 T 17-03-2017 IPR010987 Glutathione S-transferase, C-terminal-like SHXM_RS34925 aaebf4fc18d2fc3f5b2aed04bc113bd0 213 Gene3D G3DSA:3.40.50.300 36 208 7.4E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34925 aaebf4fc18d2fc3f5b2aed04bc113bd0 213 Pfam PF03029 Conserved hypothetical ATP binding protein 41 209 2.1E-25 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS34925 aaebf4fc18d2fc3f5b2aed04bc113bd0 213 SUPERFAMILY SSF52540 36 209 6.41E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19135 246c08d2e10c7a916e7ffc8d34a60aad 169 Pfam PF00719 Inorganic pyrophosphatase 8 157 1.9E-50 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS19135 246c08d2e10c7a916e7ffc8d34a60aad 169 Hamap MF_00209 Inorganic pyrophosphatase [ppa]. 4 161 31.584 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS19135 246c08d2e10c7a916e7ffc8d34a60aad 169 SUPERFAMILY SSF50324 4 156 2.35E-54 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS19135 246c08d2e10c7a916e7ffc8d34a60aad 169 Gene3D G3DSA:3.90.80.10 3 158 6.2E-52 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS19135 246c08d2e10c7a916e7ffc8d34a60aad 169 ProSitePatterns PS00387 Inorganic pyrophosphatase signature. 55 61 - T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 Pfam PF01494 FAD binding domain 4 345 5.4E-19 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 Gene3D G3DSA:3.50.50.60 276 352 1.2E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 Gene3D G3DSA:3.50.50.60 3 177 1.2E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 303 319 1.5E-11 T 17-03-2017 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 288 303 1.5E-11 T 17-03-2017 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 150 165 1.5E-11 T 17-03-2017 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 1.5E-11 T 17-03-2017 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 SUPERFAMILY SSF51905 275 354 7.38E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06300 3805c0d611008df84b8e2787d3598b4f 393 SUPERFAMILY SSF51905 4 171 7.38E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25885 7a33b4ce89b57a2c0b89656796a571f3 427 Gene3D G3DSA:3.40.190.10 54 169 9.6E-20 T 17-03-2017 SHXM_RS25885 7a33b4ce89b57a2c0b89656796a571f3 427 Gene3D G3DSA:3.40.190.10 170 351 2.2E-34 T 17-03-2017 SHXM_RS25885 7a33b4ce89b57a2c0b89656796a571f3 427 SUPERFAMILY SSF53850 53 420 1.5E-60 T 17-03-2017 SHXM_RS25885 7a33b4ce89b57a2c0b89656796a571f3 427 Pfam PF01547 Bacterial extracellular solute-binding protein 54 335 8.0E-32 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS29545 9081b5f622cc6b8c4f91ab7509d77a4e 305 SMART SM00942 230 297 2.3E-4 T 17-03-2017 IPR014820 Primase, C-terminal 1 SHXM_RS29545 9081b5f622cc6b8c4f91ab7509d77a4e 305 SUPERFAMILY SSF56747 9 201 9.15E-33 T 17-03-2017 SHXM_RS29545 9081b5f622cc6b8c4f91ab7509d77a4e 305 SMART SM00943 13 193 3.0E-48 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS29545 9081b5f622cc6b8c4f91ab7509d77a4e 305 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 13 192 4.9E-45 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS44890 042f787eda730871320f394ab54d4182 918 SUPERFAMILY SSF52540 8 157 1.05E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44890 042f787eda730871320f394ab54d4182 918 Gene3D G3DSA:1.25.40.10 522 761 4.4E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44890 042f787eda730871320f394ab54d4182 918 SMART SM00421 850 907 1.9E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS44890 042f787eda730871320f394ab54d4182 918 Pfam PF13191 AAA ATPase domain 7 150 7.0E-17 T 17-03-2017 SHXM_RS44890 042f787eda730871320f394ab54d4182 918 SUPERFAMILY SSF46894 843 908 3.13E-13 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS44890 042f787eda730871320f394ab54d4182 918 Gene3D G3DSA:3.40.50.300 110 157 1.8E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44890 042f787eda730871320f394ab54d4182 918 Gene3D G3DSA:3.40.50.300 16 74 1.8E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44890 042f787eda730871320f394ab54d4182 918 Gene3D G3DSA:1.10.10.10 848 908 6.7E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44890 042f787eda730871320f394ab54d4182 918 Pfam PF00196 Bacterial regulatory proteins, luxR family 852 906 2.2E-7 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05755 974e0fe60503352e09ca1841f1014844 404 Gene3D G3DSA:3.40.50.2000 2 222 4.8E-12 T 17-03-2017 SHXM_RS05755 974e0fe60503352e09ca1841f1014844 404 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 292 351 2.8E-9 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS05755 974e0fe60503352e09ca1841f1014844 404 SUPERFAMILY SSF53756 2 401 2.4E-56 T 17-03-2017 SHXM_RS05755 974e0fe60503352e09ca1841f1014844 404 Gene3D G3DSA:3.40.50.2000 223 385 1.9E-34 T 17-03-2017 SHXM_RS33250 1722f01720c0ffbac800675a106f9787 165 Pfam PF10415 Fumarase C C-terminus 111 134 2.2E-7 T 17-03-2017 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS33250 1722f01720c0ffbac800675a106f9787 165 Gene3D G3DSA:1.10.40.30 111 135 7.5E-9 T 17-03-2017 SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SUPERFAMILY SSF51126 87 164 1.05E-21 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SUPERFAMILY SSF51126 249 490 1.05E-21 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 Pfam PF13229 Right handed beta helix region 252 444 3.6E-14 T 17-03-2017 SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 Gene3D G3DSA:2.160.20.10 303 577 5.9E-43 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 Gene3D G3DSA:2.160.20.10 46 156 5.9E-43 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 Gene3D G3DSA:2.160.20.10 210 271 5.9E-43 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SMART SM00710 304 330 3600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SMART SM00710 354 383 1600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SMART SM00710 385 406 1700.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SMART SM00710 409 431 1700.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SMART SM00710 249 271 31.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS02925 a1ef72a68d583bb634519e7e7a48499e 590 SMART SM00710 331 353 970.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20955 6f855b69b53ed9d24f693c43f706438b 319 SMART SM00382 61 248 3.3E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20955 6f855b69b53ed9d24f693c43f706438b 319 Pfam PF07728 AAA domain (dynein-related subfamily) 65 189 3.3E-7 T 17-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 SHXM_RS20955 6f855b69b53ed9d24f693c43f706438b 319 SUPERFAMILY SSF52540 150 279 2.02E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20955 6f855b69b53ed9d24f693c43f706438b 319 SUPERFAMILY SSF52540 49 115 2.02E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20955 6f855b69b53ed9d24f693c43f706438b 319 Gene3D G3DSA:3.40.50.300 141 286 4.7E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20955 6f855b69b53ed9d24f693c43f706438b 319 Gene3D G3DSA:3.40.50.300 63 107 4.7E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 SUPERFAMILY SSF55781 94 243 1.24E-26 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 Gene3D G3DSA:1.10.10.10 12 78 4.8E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 Pfam PF09339 IclR helix-turn-helix domain 14 61 6.7E-9 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 SMART SM00346 12 97 3.6E-7 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 Gene3D G3DSA:3.30.450.40 94 243 5.1E-30 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 Pfam PF01614 Bacterial transcriptional regulator 133 243 1.6E-23 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS09520 634ee02f960b58770cf89e23c125263b 259 SUPERFAMILY SSF46785 13 77 2.69E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31685 ef67d1ec3523b14d1d33b85195502f90 219 Pfam PF13563 2'-5' RNA ligase superfamily 36 184 1.7E-6 T 17-03-2017 SHXM_RS31685 ef67d1ec3523b14d1d33b85195502f90 219 SUPERFAMILY SSF55144 8 192 1.7E-7 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS10460 a4c00b6081644167e7163729cec7c948 433 SUPERFAMILY SSF103473 13 408 6.67E-38 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS10460 a4c00b6081644167e7163729cec7c948 433 Pfam PF07690 Major Facilitator Superfamily 26 354 2.0E-26 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS10460 a4c00b6081644167e7163729cec7c948 433 Gene3D G3DSA:1.20.1250.20 19 201 1.1E-17 T 17-03-2017 SHXM_RS10460 a4c00b6081644167e7163729cec7c948 433 Gene3D G3DSA:1.20.1250.20 222 406 1.1E-8 T 17-03-2017 SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 Pfam PF00501 AMP-binding enzyme 10 396 9.7E-55 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 Pfam PF13193 AMP-binding enzyme C-terminal domain 405 481 2.9E-11 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 Gene3D G3DSA:2.30.38.10 316 389 8.6E-18 T 17-03-2017 SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 SUPERFAMILY SSF56801 11 492 4.84E-94 T 17-03-2017 SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 Gene3D G3DSA:3.30.300.30 391 490 3.3E-23 T 17-03-2017 SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 Gene3D G3DSA:3.40.50.980 160 308 1.2E-23 T 17-03-2017 SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 ProSitePatterns PS00455 Putative AMP-binding domain signature. 150 161 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS10625 683708c434b5b78c3223d4e467bed057 501 Gene3D G3DSA:3.40.50.980 9 159 6.5E-14 T 17-03-2017 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 Gene3D G3DSA:3.50.50.60 383 424 2.0E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 Gene3D G3DSA:3.50.50.60 213 280 2.0E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 Gene3D G3DSA:3.50.50.60 7 46 2.0E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 PRINTS PR00757 Flavin-containing amine oxidase signature 9 28 8.8E-7 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 PRINTS PR00757 Flavin-containing amine oxidase signature 401 418 8.8E-7 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 SUPERFAMILY SSF51905 367 422 4.26E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 SUPERFAMILY SSF51905 7 290 4.26E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19055 c8134675fe1eaf5e47c3be5c78283cc2 448 Pfam PF01593 Flavin containing amine oxidoreductase 17 420 4.0E-37 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS16960 30503123ed02fe010a071342b3ccf978 344 Pfam PF01569 PAP2 superfamily 106 221 1.6E-21 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS16960 30503123ed02fe010a071342b3ccf978 344 SUPERFAMILY SSF48317 26 224 5.23E-26 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS16960 30503123ed02fe010a071342b3ccf978 344 Gene3D G3DSA:1.20.144.10 30 223 8.5E-20 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS16960 30503123ed02fe010a071342b3ccf978 344 SMART SM00014 104 219 5.4E-8 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS32280 0547f1799bdcbe11b3c00f44426f3f6b 296 Pfam PF08021 Siderophore-interacting FAD-binding domain 23 142 2.2E-41 T 17-03-2017 IPR013113 FAD-binding 9, siderophore-interacting SHXM_RS32280 0547f1799bdcbe11b3c00f44426f3f6b 296 SUPERFAMILY SSF63380 13 140 5.45E-9 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS32280 0547f1799bdcbe11b3c00f44426f3f6b 296 Gene3D G3DSA:2.40.30.10 16 140 1.9E-36 T 17-03-2017 SHXM_RS32280 0547f1799bdcbe11b3c00f44426f3f6b 296 Gene3D G3DSA:3.40.50.80 150 282 6.2E-49 T 17-03-2017 SHXM_RS32280 0547f1799bdcbe11b3c00f44426f3f6b 296 Pfam PF04954 Siderophore-interacting protein 156 276 1.8E-41 T 17-03-2017 IPR007037 Siderophore-interacting protein SHXM_RS18970 6b643239648672b47593f7442e16b097 250 Pfam PF08241 Methyltransferase domain 37 137 2.5E-19 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS18970 6b643239648672b47593f7442e16b097 250 SUPERFAMILY SSF53335 17 231 5.27E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18970 6b643239648672b47593f7442e16b097 250 Gene3D G3DSA:3.40.50.150 23 159 2.6E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12275 cb5cba8f0f01b5dfd1f4c4354c8d305b 338 SUPERFAMILY SSF100950 74 319 1.05E-55 T 17-03-2017 SHXM_RS12275 cb5cba8f0f01b5dfd1f4c4354c8d305b 338 Gene3D G3DSA:3.40.50.1360 63 320 1.7E-68 T 17-03-2017 SHXM_RS12275 cb5cba8f0f01b5dfd1f4c4354c8d305b 338 Pfam PF04198 Putative sugar-binding domain 70 320 2.0E-67 T 17-03-2017 IPR007324 Sugar-binding domain, putative GO:0030246 SHXM_RS30790 aebbfb645bccc9c00d2f875c16f4620b 452 ProSitePatterns PS00667 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. 62 77 - T 17-03-2017 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30790 aebbfb645bccc9c00d2f875c16f4620b 452 ProSitePatterns PS00668 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. 229 242 - T 17-03-2017 IPR018086 NADH:ubiquinone oxidoreductase, subunit 1, conserved site GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30790 aebbfb645bccc9c00d2f875c16f4620b 452 Pfam PF00146 NADH dehydrogenase 23 346 4.3E-122 T 17-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30790 aebbfb645bccc9c00d2f875c16f4620b 452 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 16 353 23.96 T 17-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS06130 defe60cbfc22acf64b04b81fb0caa9d8 321 SUPERFAMILY SSF51735 1 137 4.32E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06130 defe60cbfc22acf64b04b81fb0caa9d8 321 Gene3D G3DSA:3.30.360.10 127 299 1.3E-55 T 17-03-2017 SHXM_RS06130 defe60cbfc22acf64b04b81fb0caa9d8 321 SUPERFAMILY SSF55347 123 258 7.85E-33 T 17-03-2017 SHXM_RS06130 defe60cbfc22acf64b04b81fb0caa9d8 321 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 1 121 5.8E-15 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS06130 defe60cbfc22acf64b04b81fb0caa9d8 321 Gene3D G3DSA:3.40.50.720 1 126 3.4E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03160 442e1f1582ab6a7dcd279cb88bfa99a7 142 SUPERFAMILY SSF54593 13 139 2.15E-18 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS03160 442e1f1582ab6a7dcd279cb88bfa99a7 142 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 20 134 1.7E-5 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS03160 442e1f1582ab6a7dcd279cb88bfa99a7 142 Gene3D G3DSA:3.10.180.10 19 139 4.4E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS12655 6148a2bbc84760325e16bb51314b92d6 321 SUPERFAMILY SSF161098 74 303 3.01E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12655 6148a2bbc84760325e16bb51314b92d6 321 Gene3D G3DSA:1.10.3720.10 27 307 1.7E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12655 6148a2bbc84760325e16bb51314b92d6 321 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 117 299 1.1E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS32300 40cc8f7e8fe22817795dc222a835d27e 353 Gene3D G3DSA:2.102.10.10 6 119 1.8E-27 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS32300 40cc8f7e8fe22817795dc222a835d27e 353 SUPERFAMILY SSF50022 2 120 3.54E-30 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS32300 40cc8f7e8fe22817795dc222a835d27e 353 SUPERFAMILY SSF55961 107 347 2.56E-38 T 17-03-2017 SHXM_RS32300 40cc8f7e8fe22817795dc222a835d27e 353 Pfam PF00355 Rieske [2Fe-2S] domain 9 92 1.3E-14 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS06370 19060eebffa185af5a5dff18dac23799 677 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 91 398 4.8E-38 T 17-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 SHXM_RS06370 19060eebffa185af5a5dff18dac23799 677 Gene3D G3DSA:3.40.390.10 246 339 2.8E-6 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 Gene3D G3DSA:3.30.300.30 476 581 2.0E-8 T 17-03-2017 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 Gene3D G3DSA:3.40.50.980 10 196 2.6E-32 T 17-03-2017 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 Gene3D G3DSA:2.30.38.10 418 473 1.8E-15 T 17-03-2017 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 ProSitePatterns PS00455 Putative AMP-binding domain signature. 191 202 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 Pfam PF00501 AMP-binding enzyme 18 480 5.7E-78 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 Gene3D G3DSA:3.40.50.980 344 396 4.9E-22 T 17-03-2017 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 Gene3D G3DSA:3.40.50.980 197 290 4.9E-22 T 17-03-2017 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 SUPERFAMILY SSF56801 347 594 1.2E-101 T 17-03-2017 SHXM_RS48930 11d3b74fb823847c77dd70cb1803f2c2 609 SUPERFAMILY SSF56801 9 295 1.2E-101 T 17-03-2017 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 Gene3D G3DSA:1.10.10.10 13 143 3.2E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 117 137 7.1E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 51 67 7.1E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 68 83 7.1E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 PRINTS PR00598 Bacterial regulatory protein MarR family signature 87 103 7.1E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 SMART SM00347 27 127 6.1E-20 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 Pfam PF12802 MarR family 32 90 1.5E-11 T 17-03-2017 SHXM_RS47835 c33ef5851672c9b4cbb9c1c313e138e1 169 SUPERFAMILY SSF46785 12 144 1.65E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 Gene3D G3DSA:3.40.50.720 144 247 2.7E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 Gene3D G3DSA:3.90.180.10 1 143 3.1E-41 T 17-03-2017 IPR011032 GroES-like SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 136 157 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 Pfam PF00107 Zinc-binding dehydrogenase 147 268 2.1E-24 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 SUPERFAMILY SSF50129 1 140 9.43E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 81 6.0E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 SMART SM00829 10 316 2.3E-25 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS38680 4cc89d3536263d2a76705d650969c504 318 SUPERFAMILY SSF51735 108 283 1.21E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 343 353 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 Pfam PF05922 Peptidase inhibitor I9 51 119 6.9E-10 T 17-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 Pfam PF00082 Subtilase family 151 379 3.1E-34 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 Gene3D G3DSA:3.30.70.80 42 109 2.6E-24 T 17-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 156 167 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 Gene3D G3DSA:3.40.50.200 110 381 1.6E-76 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 PRINTS PR00723 Subtilisin serine protease family (S8) signature 151 170 1.4E-17 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 PRINTS PR00723 Subtilisin serine protease family (S8) signature 189 202 1.4E-17 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 PRINTS PR00723 Subtilisin serine protease family (S8) signature 342 358 1.4E-17 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS01890 325e165f811fb411a8075aa4e3c98f92 399 SUPERFAMILY SSF52743 44 392 1.57E-70 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 11 248 9.0E-58 T 17-03-2017 SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 Gene3D G3DSA:3.40.50.720 2 247 1.3E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3 183 0.0023 T 17-03-2017 SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 SUPERFAMILY SSF51735 2 248 1.04E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 3.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 3.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08620 c0462a2165283881e51829e30cc81004 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 3.0E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS23955 c1139d0ed424126c176fe012c67ba7c3 317 Pfam PF00892 EamA-like transporter family 3 130 8.2E-15 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS23955 c1139d0ed424126c176fe012c67ba7c3 317 Pfam PF00892 EamA-like transporter family 139 271 7.9E-20 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS23955 c1139d0ed424126c176fe012c67ba7c3 317 SUPERFAMILY SSF103481 173 271 1.83E-16 T 17-03-2017 SHXM_RS23955 c1139d0ed424126c176fe012c67ba7c3 317 SUPERFAMILY SSF103481 43 133 1.02E-12 T 17-03-2017 SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 SUPERFAMILY SSF56420 33 196 1.96E-53 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 PIRSF PIRSF004749 2 208 3.0E-43 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 Gene3D G3DSA:3.90.45.10 35 201 3.6E-56 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 PRINTS PR01576 Peptide deformylase signature 64 93 4.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 PRINTS PR01576 Peptide deformylase signature 138 156 4.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 PRINTS PR01576 Peptide deformylase signature 126 137 4.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 PRINTS PR01576 Peptide deformylase signature 157 186 4.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 Hamap MF_00163 Peptide deformylase [def]. 33 199 28.088 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 TIGRFAM TIGR00079 pept_deformyl: peptide deformylase 37 196 1.7E-39 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS34490 ccfcb0de48166dc163e622ecbf43d838 209 Pfam PF01327 Polypeptide deformylase 35 189 4.6E-43 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS11960 b6f4f5b4cfebea8983ba08ba5cac4af9 447 Gene3D G3DSA:3.40.720.10 4 302 6.6E-46 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS11960 b6f4f5b4cfebea8983ba08ba5cac4af9 447 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 5 383 9.8E-45 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS11960 b6f4f5b4cfebea8983ba08ba5cac4af9 447 SUPERFAMILY SSF53649 5 422 7.56E-42 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 SUPERFAMILY SSF52540 618 913 5.78E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:3.40.50.300 616 677 3.7E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:3.40.50.300 483 601 2.1E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:3.40.50.300 6 90 2.1E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:3.40.50.300 825 943 3.7E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:3.30.1490.20 131 154 1.3E-24 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:3.30.1490.20 201 242 1.3E-24 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:1.20.1580.10 92 130 3.0E-57 T 17-03-2017 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:1.20.1580.10 255 288 3.0E-57 T 17-03-2017 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:1.20.1580.10 412 482 3.0E-57 T 17-03-2017 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:1.10.8.280 290 411 5.1E-37 T 17-03-2017 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 ProSitePatterns PS00211 ABC transporters family signature. 834 848 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Gene3D G3DSA:1.20.1580.10 698 824 4.8E-56 T 17-03-2017 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Hamap MF_00205 UvrABC system protein A [uvrA]. 2 944 22.777 T 17-03-2017 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 SUPERFAMILY SSF52540 435 574 6.26E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 SUPERFAMILY SSF52540 10 205 6.26E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 Pfam PF00005 ABC transporter 628 864 1.3E-9 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 ProSitePatterns PS00211 ABC transporters family signature. 492 506 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17970 018a988d9286209201695a485d0c7e32 1010 TIGRFAM TIGR00630 uvra: excinuclease ABC subunit A 5 929 0.0 T 17-03-2017 IPR004602 UvrABC system subunit A GO:0006289|GO:0009380|GO:0009381 SHXM_RS40665 75e575832adb29b5d3b7f4cd6bed11b0 268 Gene3D G3DSA:3.90.850.10 10 265 1.9E-82 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS40665 75e575832adb29b5d3b7f4cd6bed11b0 268 SUPERFAMILY SSF56529 10 263 3.4E-73 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS40665 75e575832adb29b5d3b7f4cd6bed11b0 268 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 82 262 1.5E-14 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS42460 2f8669ebf897c88aff0c8e0c558c01b2 453 SUPERFAMILY SSF53383 15 452 3.3E-78 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS42460 2f8669ebf897c88aff0c8e0c558c01b2 453 Pfam PF00282 Pyridoxal-dependent decarboxylase conserved domain 70 367 5.2E-24 T 17-03-2017 IPR002129 Pyridoxal phosphate-dependent decarboxylase GO:0016831|GO:0019752|GO:0030170 SHXM_RS42460 2f8669ebf897c88aff0c8e0c558c01b2 453 ProSitePatterns PS00392 DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. 255 276 - T 17-03-2017 IPR021115 Pyridoxal-phosphate binding site GO:0016831 SHXM_RS42460 2f8669ebf897c88aff0c8e0c558c01b2 453 Gene3D G3DSA:3.40.640.10 71 316 1.3E-61 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS42460 2f8669ebf897c88aff0c8e0c558c01b2 453 Gene3D G3DSA:3.90.1150.10 317 452 5.8E-9 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 95 107 6.0E-5 T 17-03-2017 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 1 9 6.0E-5 T 17-03-2017 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 PRINTS PR00507 N12 class N6 adenine-specific DNA methyltransferase signature 33 47 6.0E-5 T 17-03-2017 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 SUPERFAMILY SSF53335 3 170 9.65E-35 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 98 104 - T 17-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 Pfam PF05175 Methyltransferase small domain 3 166 1.2E-16 T 17-03-2017 IPR007848 Methyltransferase small domain GO:0008168 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 TIGRFAM TIGR00537 hemK_rel_arch: putative methylase 9 184 7.3E-35 T 17-03-2017 IPR004557 Eukaryotic/archaeal PrmC-related GO:0008276 Reactome: R-HSA-156581|Reactome: R-HSA-72764 SHXM_RS13900 ab733f7a794bb7cd98bebd6f376fd38e 216 Gene3D G3DSA:3.40.50.150 3 173 2.6E-38 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS31510 7f59ea3511c0d65d7634bcb4521482a9 283 Gene3D G3DSA:1.10.260.40 4 68 7.1E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS31510 7f59ea3511c0d65d7634bcb4521482a9 283 SUPERFAMILY SSF47413 10 69 1.66E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS31510 7f59ea3511c0d65d7634bcb4521482a9 283 SMART SM00530 17 72 1.3E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS31510 7f59ea3511c0d65d7634bcb4521482a9 283 Pfam PF13560 Helix-turn-helix domain 13 68 1.3E-10 T 17-03-2017 SHXM_RS41555 ecac8ad49f5bf6c01823a3bd7a430673 247 SUPERFAMILY SSF52218 23 246 2.51E-29 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS41555 ecac8ad49f5bf6c01823a3bd7a430673 247 Gene3D G3DSA:3.40.50.360 23 176 6.0E-15 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS41555 ecac8ad49f5bf6c01823a3bd7a430673 247 Pfam PF03358 NADPH-dependent FMN reductase 32 173 1.8E-11 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS36670 c8d261b4017a4bda05dfb5197e77ef96 185 TIGRFAM TIGR00496 frr: ribosome recycling factor 10 185 3.4E-61 T 17-03-2017 IPR002661 Ribosome recycling factor GO:0006412 Reactome: R-HSA-5419276 SHXM_RS36670 c8d261b4017a4bda05dfb5197e77ef96 185 Pfam PF01765 Ribosome recycling factor 21 183 8.4E-57 T 17-03-2017 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 SHXM_RS36670 c8d261b4017a4bda05dfb5197e77ef96 185 Gene3D G3DSA:1.10.132.20 66 185 2.8E-39 T 17-03-2017 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 SHXM_RS36670 c8d261b4017a4bda05dfb5197e77ef96 185 Hamap MF_00040 Ribosome-recycling factor [frr]. 3 185 26.558 T 17-03-2017 IPR002661 Ribosome recycling factor GO:0006412 Reactome: R-HSA-5419276 SHXM_RS36670 c8d261b4017a4bda05dfb5197e77ef96 185 SUPERFAMILY SSF55194 3 184 1.57E-65 T 17-03-2017 IPR023584 Ribosome recycling factor domain Reactome: R-HSA-5419276 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Pfam PF13424 Tetratricopeptide repeat 991 1057 1.1E-7 T 17-03-2017 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Pfam PF13424 Tetratricopeptide repeat 901 971 7.0E-14 T 17-03-2017 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Pfam PF13424 Tetratricopeptide repeat 1068 1132 1.8E-14 T 17-03-2017 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SUPERFAMILY SSF48452 641 719 8.67E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Pfam PF13374 Tetratricopeptide repeat 653 684 3.2E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Pfam PF13374 Tetratricopeptide repeat 739 771 0.0032 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SUPERFAMILY SSF48452 700 802 3.0E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SMART SM00028 648 681 200.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SMART SM00028 1111 1144 31.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SMART SM00028 901 934 80.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SMART SM00028 1069 1102 50.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SUPERFAMILY SSF48452 811 930 2.15E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SUPERFAMILY SSF48452 894 1011 4.07E-16 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 SUPERFAMILY SSF48452 1021 1143 9.76E-17 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Gene3D G3DSA:1.25.40.10 643 826 1.5E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS20950 623916cff649637e2f12f0b360f0af00 1171 Gene3D G3DSA:1.25.40.10 827 1141 2.8E-32 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 SMART SM00825 Beta-ketoacyl synthase 1 422 2.1E-220 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 157 173 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Gene3D G3DSA:3.30.70.250 701 732 6.0E-4 T 17-03-2017 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Gene3D G3DSA:3.40.366.10 738 861 5.5E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Gene3D G3DSA:3.40.366.10 552 679 5.5E-75 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 SUPERFAMILY SSF55048 682 734 2.62E-7 T 17-03-2017 IPR016036 Malonyl-CoA ACP transacylase, ACP-binding GO:0003824|GO:0008152 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 SMART SM00827 Acyl transferase domain in polyketide synthase (PKS) enzymes. 562 847 5.0E-113 T 17-03-2017 IPR020801 Polyketide synthase, acyl transferase domain SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 372 432 4.0E-9 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 SUPERFAMILY SSF52151 559 684 6.02E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 SUPERFAMILY SSF52151 739 837 6.02E-69 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Gene3D G3DSA:3.40.47.10 1 256 1.6E-92 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 252 369 7.2E-47 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Pfam PF00698 Acyl transferase domain 560 865 1.2E-84 T 17-03-2017 IPR014043 Acyl transferase SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 244 4.5E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 Gene3D G3DSA:3.40.47.10 257 421 3.8E-67 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05315 d58e905a554b799c8ab944016137b197 865 SUPERFAMILY SSF53901 1 367 3.95E-104 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS03735 80a1b2dfc6b75b374ff95b12bfffb123 287 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 8 250 3.1E-57 T 17-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 SHXM_RS03735 80a1b2dfc6b75b374ff95b12bfffb123 287 SUPERFAMILY SSF51197 8 259 7.78E-85 T 17-03-2017 SHXM_RS03735 80a1b2dfc6b75b374ff95b12bfffb123 287 Gene3D G3DSA:3.60.130.10 4 262 8.8E-91 T 17-03-2017 SHXM_RS31640 ab3ee54e7428a849b86687fa2f503ec0 334 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 197 305 3.1E-23 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31640 ab3ee54e7428a849b86687fa2f503ec0 334 Gene3D G3DSA:1.10.540.10 2 93 2.9E-15 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31640 ab3ee54e7428a849b86687fa2f503ec0 334 Gene3D G3DSA:1.20.140.10 195 306 5.5E-28 T 17-03-2017 SHXM_RS31640 ab3ee54e7428a849b86687fa2f503ec0 334 SUPERFAMILY SSF47203 195 307 1.61E-29 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31640 ab3ee54e7428a849b86687fa2f503ec0 334 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 93 1.1E-12 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31640 ab3ee54e7428a849b86687fa2f503ec0 334 SUPERFAMILY SSF56645 2 100 2.49E-15 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 260 407 6.5E-20 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 SUPERFAMILY SSF47203 258 407 1.93E-29 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 Gene3D G3DSA:2.40.110.10 155 233 1.9E-4 T 17-03-2017 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 118 1.3E-19 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 Gene3D G3DSA:1.10.540.10 1 119 1.7E-21 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 Gene3D G3DSA:1.20.140.10 258 406 6.2E-28 T 17-03-2017 SHXM_RS31760 f0b675e5190f45fca4a476cbcfe410aa 467 SUPERFAMILY SSF56645 1 237 7.46E-28 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS07200 fd43ab353a374d2676167fe6e48d50ab 302 ProSitePatterns PS00211 ABC transporters family signature. 130 144 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS07200 fd43ab353a374d2676167fe6e48d50ab 302 Pfam PF00005 ABC transporter 20 157 3.5E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS07200 fd43ab353a374d2676167fe6e48d50ab 302 SMART SM00382 28 214 1.7E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS07200 fd43ab353a374d2676167fe6e48d50ab 302 Gene3D G3DSA:3.40.50.300 2 233 5.0E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07200 fd43ab353a374d2676167fe6e48d50ab 302 SUPERFAMILY SSF52540 2 235 2.37E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40745 4a988f2ef69a03057b2c9c908972dcb6 270 SUPERFAMILY SSF47413 32 81 4.3E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40745 4a988f2ef69a03057b2c9c908972dcb6 270 Gene3D G3DSA:1.10.260.40 6 81 8.5E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40745 4a988f2ef69a03057b2c9c908972dcb6 270 SMART SM00530 12 84 2.0E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS40745 4a988f2ef69a03057b2c9c908972dcb6 270 Pfam PF13560 Helix-turn-helix domain 9 87 8.2E-14 T 17-03-2017 SHXM_RS36185 7bee9e17170733b8fd89fe23038f9066 189 SUPERFAMILY SSF52833 4 99 5.44E-17 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS36185 7bee9e17170733b8fd89fe23038f9066 189 SUPERFAMILY SSF52833 135 179 5.44E-17 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS36185 7bee9e17170733b8fd89fe23038f9066 189 Pfam PF00578 AhpC/TSA family 27 157 1.2E-8 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS36185 7bee9e17170733b8fd89fe23038f9066 189 Gene3D G3DSA:3.40.30.10 138 159 1.3E-10 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS36185 7bee9e17170733b8fd89fe23038f9066 189 Gene3D G3DSA:3.40.30.10 3 101 1.3E-10 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS34960 e6be29d97c66cf13f72dc9668bdf3e09 170 SUPERFAMILY SSF55729 2 141 1.22E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS34960 e6be29d97c66cf13f72dc9668bdf3e09 170 Gene3D G3DSA:3.40.630.30 2 152 6.5E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS34960 e6be29d97c66cf13f72dc9668bdf3e09 170 Pfam PF00583 Acetyltransferase (GNAT) family 64 134 2.3E-10 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS46385 5a684eadbce0459d2ff22472b7dbc070 173 SUPERFAMILY SSF55961 1 140 4.02E-19 T 17-03-2017 SHXM_RS46385 5a684eadbce0459d2ff22472b7dbc070 173 Gene3D G3DSA:3.30.530.20 3 137 2.6E-6 T 17-03-2017 IPR023393 START-like domain SHXM_RS46385 5a684eadbce0459d2ff22472b7dbc070 173 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 10 126 2.9E-10 T 17-03-2017 IPR005031 Coenzyme Q-binding protein COQ10, START domain SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 SUPERFAMILY SSF56003 121 709 6.8E-159 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.30.365.10 443 538 2.3E-23 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 25 129 1.6E-19 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.30.365.10 286 312 1.3E-8 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.30.365.10 117 179 1.3E-8 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 SUPERFAMILY SSF54665 8 132 1.01E-31 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 SMART SM01008 25 129 3.0E-32 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.90.1170.50 9 116 1.1E-29 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 551 651 3.3E-25 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 168 549 1.5E-89 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.30.365.10 180 282 1.6E-34 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.30.365.10 359 442 4.7E-59 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS16245 253fadec18bf5dc4e5d6e760ec67dddd 710 Gene3D G3DSA:3.30.365.10 568 708 4.7E-59 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 Gene3D G3DSA:1.10.10.10 4 77 1.9E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 36 50 2.5E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 50 66 2.5E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 SMART SM00895 86 212 3.5E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 Gene3D G3DSA:1.20.120.530 80 223 3.1E-29 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 Pfam PF00392 Bacterial regulatory proteins, gntR family 16 76 2.1E-23 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 SUPERFAMILY SSF46785 9 102 1.78E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 SMART SM00345 18 76 1.5E-23 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 Pfam PF07729 FCD domain 86 211 4.5E-27 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS06805 43270327e91b15dfe2ec3560d27e8cb9 226 SUPERFAMILY SSF48008 83 219 5.75E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS13050 0c5f7efe6bbb949c7957980f12e80035 68 Pfam PF08940 Domain of unknown function (DUF1918) 1 58 8.9E-29 T 17-03-2017 IPR015035 Domain of unknown function DUF1918 SHXM_RS13050 0c5f7efe6bbb949c7957980f12e80035 68 SUPERFAMILY SSF50118 1 63 9.81E-25 T 17-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor SHXM_RS21315 62434d59c84507267ab1c34f9eb753b5 699 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 464 698 1.9E-42 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21315 62434d59c84507267ab1c34f9eb753b5 699 SMART SM00331 438 698 4.2E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS21315 62434d59c84507267ab1c34f9eb753b5 699 SUPERFAMILY SSF55781 296 416 8.83E-9 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS21315 62434d59c84507267ab1c34f9eb753b5 699 Gene3D G3DSA:3.30.450.40 268 415 4.8E-7 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS21315 62434d59c84507267ab1c34f9eb753b5 699 Pfam PF13581 Histidine kinase-like ATPase domain 51 168 6.4E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 98 111 8.1E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 3 14 8.1E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 149 169 8.1E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 131 147 8.1E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 SUPERFAMILY SSF56784 2 213 5.47E-53 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 Pfam PF13419 Haloacid dehalogenase-like hydrolase 6 186 3.2E-28 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 Gene3D G3DSA:3.40.50.1000 89 213 1.4E-44 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 Gene3D G3DSA:3.40.50.1000 1 17 1.4E-44 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 Gene3D G3DSA:1.10.150.240 18 84 7.2E-13 T 17-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 78 169 1.5E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS30395 bf7a0f4bf05e1a96d80e12ee6ce55fe3 218 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 69 187 3.2E-17 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS08285 096d9c38b90d70761fc2da7d72d97832 222 Pfam PF01738 Dienelactone hydrolase family 85 212 1.9E-9 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS08285 096d9c38b90d70761fc2da7d72d97832 222 SUPERFAMILY SSF53474 4 209 2.63E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08285 096d9c38b90d70761fc2da7d72d97832 222 Gene3D G3DSA:3.40.50.1820 2 211 2.7E-44 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS21035 915057936d95de364386fbc30c6729b7 141 Gene3D G3DSA:1.10.10.10 11 78 3.3E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21035 915057936d95de364386fbc30c6729b7 141 SUPERFAMILY SSF46785 11 132 3.71E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21035 915057936d95de364386fbc30c6729b7 141 Pfam PF01475 Ferric uptake regulator family 11 126 8.5E-32 T 17-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SHXM_RS05145 09c6822bb57871b0e7b4857567bb9f1b 193 ProSitePatterns PS01081 TetR-type HTH domain signature. 29 60 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS05145 09c6822bb57871b0e7b4857567bb9f1b 193 Gene3D G3DSA:1.10.357.10 57 187 3.3E-21 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS05145 09c6822bb57871b0e7b4857567bb9f1b 193 Gene3D G3DSA:1.10.10.60 6 56 4.9E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05145 09c6822bb57871b0e7b4857567bb9f1b 193 Pfam PF00440 Bacterial regulatory proteins, tetR family 19 58 2.6E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05145 09c6822bb57871b0e7b4857567bb9f1b 193 SUPERFAMILY SSF46689 5 77 8.98E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 Pfam PF01261 Xylose isomerase-like TIM barrel 41 265 1.0E-26 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 Gene3D G3DSA:3.20.20.150 2 386 1.6E-141 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 TIGRFAM TIGR02631 xylA_Arthro: xylose isomerase 3 386 3.5E-222 T 17-03-2017 IPR013453 Xylose isomerase, actinobacteria GO:0009045|GO:0042732 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 Hamap MF_00455 Xylose isomerase [xylA]. 1 385 37.749 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 SUPERFAMILY SSF51658 2 387 5.89E-116 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 105 124 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 178 202 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 281 292 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 129 150 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 156 175 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 248 259 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 82 102 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 45 67 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS45085 0781451b4e6353c5cad31a0b771302aa 390 PRINTS PR00688 Xylose isomerase signature 220 247 8.4E-74 T 17-03-2017 IPR001998 Xylose isomerase GO:0005975|GO:0009045 KEGG: 00040+5.3.1.5|KEGG: 00051+5.3.1.5 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 SUPERFAMILY SSF158472 83 130 1.23E-11 T 17-03-2017 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 Gene3D G3DSA:1.10.287.130 125 185 3.7E-16 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 Gene3D G3DSA:3.30.565.10 186 378 3.6E-38 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 SUPERFAMILY SSF55874 188 380 5.11E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 Pfam PF00512 His Kinase A (phospho-acceptor) domain 136 199 1.1E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 Pfam PF00672 HAMP domain 63 130 4.3E-15 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 255 377 1.0E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 PRINTS PR00344 Bacterial sensor protein C-terminal signature 294 308 8.2E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 PRINTS PR00344 Bacterial sensor protein C-terminal signature 364 377 8.2E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 PRINTS PR00344 Bacterial sensor protein C-terminal signature 341 359 8.2E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 SMART SM00304 81 134 8.1E-14 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 SUPERFAMILY SSF47384 118 199 2.55E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 SMART SM00387 254 380 4.8E-33 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34850 ded0fa5ff744379bbdc5450f8de39b42 388 SMART SM00388 135 199 9.1E-18 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS18580 d79763a0b0f5bad4937fc1e097d4f957 355 ProSitePatterns PS01348 MraY family signature 2. 174 185 - T 17-03-2017 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18580 d79763a0b0f5bad4937fc1e097d4f957 355 ProSitePatterns PS01347 MraY family signature 1. 46 58 - T 17-03-2017 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18580 d79763a0b0f5bad4937fc1e097d4f957 355 Pfam PF00953 Glycosyl transferase family 4 82 275 1.7E-36 T 17-03-2017 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-4549356 SHXM_RS18580 d79763a0b0f5bad4937fc1e097d4f957 355 Hamap MF_00038 Phospho-N-acetylmuramoyl-pentapeptide-transferase [mraY]. 3 349 23.726 T 17-03-2017 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18580 d79763a0b0f5bad4937fc1e097d4f957 355 TIGRFAM TIGR00445 mraY: phospho-N-acetylmuramoyl-pentapeptide-transferase 17 345 1.0E-97 T 17-03-2017 IPR003524 Phospho-N-acetylmuramoyl-pentapeptide transferase GO:0008963|GO:0016020 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS18580 d79763a0b0f5bad4937fc1e097d4f957 355 Pfam PF10555 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 46 55 6.7E-4 T 17-03-2017 IPR018480 Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS50545 fd95e66c57cfdc53f981e0cd3866bab5 295 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 92 285 9.9E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50545 fd95e66c57cfdc53f981e0cd3866bab5 295 SUPERFAMILY SSF161098 60 280 1.06E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50545 fd95e66c57cfdc53f981e0cd3866bab5 295 Gene3D G3DSA:1.10.3720.10 66 292 5.4E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 Gene3D G3DSA:1.10.10.10 123 216 4.9E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 SMART SM00862 145 216 8.5E-21 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 Pfam PF00486 Transcriptional regulatory protein, C terminal 148 216 7.9E-18 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 Pfam PF00072 Response regulator receiver domain 3 112 1.7E-21 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 SMART SM00448 1 112 1.8E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 SUPERFAMILY SSF52172 1 172 3.7E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS40110 12b1f2c93742603f17512dd8b4c31374 216 Gene3D G3DSA:3.40.50.2300 1 119 8.8E-32 T 17-03-2017 SHXM_RS16970 7d315eb73d8b3104ae44e7108f27ddb7 100 Pfam PF05800 Gas vesicle synthesis protein GvpO 18 98 1.5E-28 T 17-03-2017 IPR008634 Gas vesicle protein GvpO GO:0031412 SHXM_RS16970 7d315eb73d8b3104ae44e7108f27ddb7 100 PIRSF PIRSF028743 1 100 1.4E-30 T 17-03-2017 IPR008634 Gas vesicle protein GvpO GO:0031412 SHXM_RS39365 d6792d536add64e07bf477f26a44b602 179 SUPERFAMILY SSF54593 4 157 2.55E-29 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS39365 d6792d536add64e07bf477f26a44b602 179 Gene3D G3DSA:3.10.180.10 4 154 5.4E-40 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS39365 d6792d536add64e07bf477f26a44b602 179 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 11 128 1.2E-17 T 17-03-2017 SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 SUPERFAMILY SSF56235 47 265 7.94E-59 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 Gene3D G3DSA:3.60.20.10 54 262 5.9E-56 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 TIGRFAM TIGR03690 20S_bact_beta: proteasome, beta subunit 50 269 2.9E-116 T 17-03-2017 IPR022483 Peptidase T1A, proteasome beta-subunit, actinobacteria GO:0004298|GO:0005839|GO:0010498 SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 Pfam PF00227 Proteasome subunit 52 230 3.6E-37 T 17-03-2017 IPR001353 Proteasome, subunit alpha/beta GO:0004298|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 Hamap MF_02113_B Proteasome subunit beta [prcB]. 7 275 50.354 T 17-03-2017 IPR022483 Peptidase T1A, proteasome beta-subunit, actinobacteria GO:0004298|GO:0005839|GO:0010498 SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 PRINTS PR00141 Proteasome component signature 61 76 5.3E-7 T 17-03-2017 IPR000243 Peptidase T1A, proteasome beta-subunit GO:0004175|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 PRINTS PR00141 Proteasome component signature 188 199 5.3E-7 T 17-03-2017 IPR000243 Peptidase T1A, proteasome beta-subunit GO:0004175|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 SHXM_RS15915 bcb754c4c067e1bbad5c1ad6da1ff2aa 281 PRINTS PR00141 Proteasome component signature 199 210 5.3E-7 T 17-03-2017 IPR000243 Peptidase T1A, proteasome beta-subunit GO:0004175|GO:0005839|GO:0051603 Reactome: R-HSA-1169091|Reactome: R-HSA-1236974|Reactome: R-HSA-1236978|Reactome: R-HSA-174084|Reactome: R-HSA-174113|Reactome: R-HSA-174154|Reactome: R-HSA-174178|Reactome: R-HSA-174184|Reactome: R-HSA-180534|Reactome: R-HSA-180585|Reactome: R-HSA-187577|Reactome: R-HSA-195253|Reactome: R-HSA-202424|Reactome: R-HSA-211733|Reactome: R-HSA-2467813|Reactome: R-HSA-2871837|Reactome: R-HSA-349425|Reactome: R-HSA-350562|Reactome: R-HSA-450408|Reactome: R-HSA-4608870|Reactome: R-HSA-4641257|Reactome: R-HSA-4641258|Reactome: R-HSA-5358346|Reactome: R-HSA-5362768|Reactome: R-HSA-5607761|Reactome: R-HSA-5607764|Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5632684|Reactome: R-HSA-5658442|Reactome: R-HSA-5668541|Reactome: R-HSA-5676590|Reactome: R-HSA-5687128|Reactome: R-HSA-68827|Reactome: R-HSA-68949|Reactome: R-HSA-69017|Reactome: R-HSA-69229|Reactome: R-HSA-69481|Reactome: R-HSA-69601|Reactome: R-HSA-8852276|Reactome: R-HSA-983168 SHXM_RS24240 c55e9569ffca32ac72b086d15780ee6b 368 SUPERFAMILY SSF53448 12 250 5.16E-68 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24240 c55e9569ffca32ac72b086d15780ee6b 368 SUPERFAMILY SSF53448 287 335 5.16E-68 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24240 c55e9569ffca32ac72b086d15780ee6b 368 Gene3D G3DSA:3.90.550.10 12 290 5.2E-74 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24240 c55e9569ffca32ac72b086d15780ee6b 368 Pfam PF00483 Nucleotidyl transferase 12 244 4.6E-45 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS24240 c55e9569ffca32ac72b086d15780ee6b 368 Gene3D G3DSA:2.160.10.10 291 341 4.8E-6 T 17-03-2017 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 Pfam PF01195 Peptidyl-tRNA hydrolase 9 191 5.0E-51 T 17-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 ProSitePatterns PS01195 Peptidyl-tRNA hydrolase signature 1. 20 33 - T 17-03-2017 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 Hamap MF_00083 Peptidyl-tRNA hydrolase [pth]. 7 188 32.535 T 17-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 TIGRFAM TIGR00447 pth: aminoacyl-tRNA hydrolase 9 195 1.5E-50 T 17-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 Gene3D G3DSA:3.40.50.1470 4 195 2.0E-68 T 17-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 SUPERFAMILY SSF53178 7 195 2.22E-62 T 17-03-2017 IPR001328 Peptidyl-tRNA hydrolase GO:0004045 MetaCyc: PWY-6308 SHXM_RS32790 99e4dfd77630e122b7647910ec642a66 196 ProSitePatterns PS01196 Peptidyl-tRNA hydrolase signature 2. 118 128 - T 17-03-2017 IPR018171 Peptidyl-tRNA hydrolase, conserved site GO:0004045 MetaCyc: PWY-6308 SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 SUPERFAMILY SSF52540 258 496 6.36E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 SUPERFAMILY SSF52540 10 230 1.08E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 SMART SM00382 36 225 6.5E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 SMART SM00382 290 484 4.2E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 Gene3D G3DSA:3.40.50.300 4 230 1.6E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 Gene3D G3DSA:3.40.50.300 282 497 1.3E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 ProSitePatterns PS00211 ABC transporters family signature. 408 422 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 Pfam PF00005 ABC transporter 27 177 4.2E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS14210 768e0f676ea4b0f008332c7c3c0cc690 509 Pfam PF00005 ABC transporter 283 435 1.9E-19 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS14590 34d27e83ac5ff5a285f820a0764ca269 398 Pfam PF08448 PAS fold 83 175 2.1E-8 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS14590 34d27e83ac5ff5a285f820a0764ca269 398 Gene3D G3DSA:3.30.450.20 73 166 4.4E-10 T 17-03-2017 SHXM_RS14590 34d27e83ac5ff5a285f820a0764ca269 398 Gene3D G3DSA:3.30.450.40 238 386 2.7E-9 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14590 34d27e83ac5ff5a285f820a0764ca269 398 SUPERFAMILY SSF55785 75 166 1.5E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 469 487 1.1E-27 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 395 413 1.1E-27 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 502 516 1.1E-27 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 PRINTS PR00300 ATP-dependent Clp protease ATP-binding subunit signature 440 458 1.1E-27 T 17-03-2017 IPR001270 ClpA/B family GO:0005524 SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 Gene3D G3DSA:3.40.50.300 556 586 2.1E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 Gene3D G3DSA:3.40.50.300 347 515 2.1E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 579 657 4.1E-7 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 Gene3D G3DSA:1.10.8.60 587 659 6.3E-6 T 17-03-2017 SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 SMART SM01086 576 669 1.4E-4 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 SUPERFAMILY SSF52540 346 644 1.02E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 Pfam PF07724 AAA domain (Cdc48 subfamily) 391 566 4.5E-36 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS04990 bdc24e58b56c0fe6c6dcd04ca6a74e13 689 SMART SM00382 391 561 7.9E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS04705 6113ea55c7ee03b8460e314644b3ad04 488 SUPERFAMILY SSF53649 2 458 9.16E-111 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS04705 6113ea55c7ee03b8460e314644b3ad04 488 Pfam PF16347 Domain of unknown function (DUF4976) 367 455 4.0E-9 T 17-03-2017 IPR032506 Domain of unknown function DUF4976 Reactome: R-HSA-2024096|Reactome: R-HSA-2206307 SHXM_RS04705 6113ea55c7ee03b8460e314644b3ad04 488 ProSitePatterns PS00523 Sulfatases signature 1. 47 59 - T 17-03-2017 IPR024607 Sulfatase, conserved site SHXM_RS04705 6113ea55c7ee03b8460e314644b3ad04 488 Gene3D G3DSA:3.40.720.10 2 379 3.3E-93 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS04705 6113ea55c7ee03b8460e314644b3ad04 488 Gene3D G3DSA:3.30.1120.10 388 467 9.4E-15 T 17-03-2017 SHXM_RS04705 6113ea55c7ee03b8460e314644b3ad04 488 Pfam PF00884 Sulfatase 2 359 4.5E-59 T 17-03-2017 IPR000917 Sulfatase, N-terminal GO:0008152|GO:0008484 SHXM_RS04915 53295ff66bd033608943ed50e219b465 186 Gene3D G3DSA:3.40.630.30 11 181 1.9E-40 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS04915 53295ff66bd033608943ed50e219b465 186 Pfam PF13302 Acetyltransferase (GNAT) domain 12 151 3.9E-19 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS04915 53295ff66bd033608943ed50e219b465 186 SUPERFAMILY SSF55729 9 175 1.95E-37 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS17935 7eefa5bf1b3fb3c5cfbb4bcd031bfccf 329 Pfam PF14527 WhiA LAGLIDADG-like domain 127 218 6.5E-24 T 17-03-2017 SHXM_RS17935 7eefa5bf1b3fb3c5cfbb4bcd031bfccf 329 Pfam PF02650 WhiA C-terminal HTH domain 221 303 2.4E-19 T 17-03-2017 IPR023054 Sporulation regulator WhiA, C-terminal SHXM_RS17935 7eefa5bf1b3fb3c5cfbb4bcd031bfccf 329 Hamap MF_01420 Putative sporulation transcription regulator WhiA [whiA]. 3 306 29.71 T 17-03-2017 IPR003802 Sporulation regulator WhiA GO:0043937 SHXM_RS17935 7eefa5bf1b3fb3c5cfbb4bcd031bfccf 329 Pfam PF10298 WhiA N-terminal LAGLIDADG-like domain 20 104 2.7E-25 T 17-03-2017 IPR018478 Sporulation transcription regulator WhiA, N-terminal domain SHXM_RS17935 7eefa5bf1b3fb3c5cfbb4bcd031bfccf 329 TIGRFAM TIGR00647 DNA_bind_WhiA: DNA-binding protein WhiA 4 304 1.7E-110 T 17-03-2017 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 Pfam PF13424 Tetratricopeptide repeat 562 633 3.0E-8 T 17-03-2017 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 Pfam PF13424 Tetratricopeptide repeat 648 710 1.5E-8 T 17-03-2017 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SUPERFAMILY SSF48452 471 633 9.1E-18 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SMART SM00028 563 596 14.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SMART SM00028 523 556 65.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SMART SM00028 683 716 1.2 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SMART SM00028 643 676 29.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SMART SM00028 483 516 14.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 Gene3D G3DSA:3.40.50.300 59 151 4.9E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 Gene3D G3DSA:1.25.40.10 651 751 2.2E-13 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 Gene3D G3DSA:1.25.40.10 470 650 9.0E-22 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SUPERFAMILY SSF52540 25 296 8.26E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 SUPERFAMILY SSF48452 599 751 5.35E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 Pfam PF00931 NB-ARC domain 45 237 1.8E-6 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 PRINTS PR00364 Disease resistance protein signature 59 74 5.1E-7 T 17-03-2017 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 PRINTS PR00364 Disease resistance protein signature 225 239 5.1E-7 T 17-03-2017 SHXM_RS35025 a55dfcb1133bfb631ff352637ef8f7bb 775 PRINTS PR00364 Disease resistance protein signature 137 151 5.1E-7 T 17-03-2017 SHXM_RS41550 889bc05b431348fa3a196794152026f7 208 SUPERFAMILY SSF89562 11 184 1.57E-26 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS41550 889bc05b431348fa3a196794152026f7 208 Gene3D G3DSA:3.50.30.40 12 178 5.6E-29 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS41550 889bc05b431348fa3a196794152026f7 208 Pfam PF03737 Demethylmenaquinone methyltransferase 15 173 3.7E-27 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS12100 fdf669ad4eaf445b5ef99018ec3a7732 489 SUPERFAMILY SSF53720 14 486 2.36E-141 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS12100 fdf669ad4eaf445b5ef99018ec3a7732 489 Gene3D G3DSA:3.40.605.10 19 276 6.1E-77 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS12100 fdf669ad4eaf445b5ef99018ec3a7732 489 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 261 268 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS12100 fdf669ad4eaf445b5ef99018ec3a7732 489 Gene3D G3DSA:3.40.309.10 277 459 1.7E-63 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS12100 fdf669ad4eaf445b5ef99018ec3a7732 489 Pfam PF00171 Aldehyde dehydrogenase family 26 483 8.1E-152 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS24435 b24638a80ae40cafc0ce1f2fe4c12a32 225 SUPERFAMILY SSF161098 22 206 5.89E-33 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24435 b24638a80ae40cafc0ce1f2fe4c12a32 225 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 47 216 2.2E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24435 b24638a80ae40cafc0ce1f2fe4c12a32 225 Gene3D G3DSA:1.10.3720.10 22 207 1.8E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 Pfam PF00501 AMP-binding enzyme 23 466 4.3E-99 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 SUPERFAMILY SSF56801 17 288 3.01E-114 T 17-03-2017 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 SUPERFAMILY SSF56801 337 596 3.01E-114 T 17-03-2017 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 Gene3D G3DSA:2.30.38.10 397 457 8.8E-20 T 17-03-2017 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 Gene3D G3DSA:3.40.50.980 190 283 1.3E-26 T 17-03-2017 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 Gene3D G3DSA:3.40.50.980 334 396 1.3E-26 T 17-03-2017 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 Gene3D G3DSA:3.30.300.30 464 584 8.1E-6 T 17-03-2017 SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 ProSitePatterns PS00455 Putative AMP-binding domain signature. 183 194 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS18815 d3d24403a3edc271f3a6e8f2f5e1cc0f 598 Gene3D G3DSA:3.40.50.980 17 189 3.4E-35 T 17-03-2017 SHXM_RS10500 a70b5592b0dd96b9f6b2b21ad35f726a 206 Pfam PF01613 Flavin reductase like domain 24 158 4.5E-23 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS10500 a70b5592b0dd96b9f6b2b21ad35f726a 206 SUPERFAMILY SSF50475 3 189 4.16E-48 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS10500 a70b5592b0dd96b9f6b2b21ad35f726a 206 SMART SM00903 21 165 8.1E-14 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS10500 a70b5592b0dd96b9f6b2b21ad35f726a 206 Gene3D G3DSA:2.30.110.10 3 190 1.4E-61 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18530 c09b6455878f138c4fbabb4ff1109bd6 396 TIGRFAM TIGR03544 DivI1A_domain: DivIVA domain 3 38 1.4E-16 T 17-03-2017 IPR019933 DivIVA domain SHXM_RS18530 c09b6455878f138c4fbabb4ff1109bd6 396 Pfam PF05103 DivIVA protein 3 64 5.6E-14 T 17-03-2017 IPR007793 DivIVA family SHXM_RS32890 8185283295e615752a5a960dd711c541 123 SUPERFAMILY SSF54593 7 119 7.43E-20 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS32890 8185283295e615752a5a960dd711c541 123 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 118 4.1E-7 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS32890 8185283295e615752a5a960dd711c541 123 Gene3D G3DSA:3.10.180.10 10 119 2.7E-17 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS34780 a7cf056a406e18a1ec1bcf911178ad5f 264 Gene3D G3DSA:3.30.70.900 129 244 6.6E-25 T 17-03-2017 SHXM_RS34780 a7cf056a406e18a1ec1bcf911178ad5f 264 Gene3D G3DSA:3.30.70.900 15 116 1.4E-23 T 17-03-2017 SHXM_RS34780 a7cf056a406e18a1ec1bcf911178ad5f 264 SUPERFAMILY SSF54909 28 89 6.34E-6 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS34780 a7cf056a406e18a1ec1bcf911178ad5f 264 Pfam PF03992 Antibiotic biosynthesis monooxygenase 137 211 7.6E-5 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS17625 b33b143bf2fff01ad5454b89f0869d1b 326 SUPERFAMILY SSF51430 1 322 1.83E-107 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS17625 b33b143bf2fff01ad5454b89f0869d1b 326 Pfam PF00248 Aldo/keto reductase family 15 314 9.6E-78 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS17625 b33b143bf2fff01ad5454b89f0869d1b 326 Gene3D G3DSA:3.20.20.100 9 324 4.1E-106 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS13675 3ef514068869db93d70f137222d38a24 386 Pfam PF00296 Luciferase-like monooxygenase 4 333 3.0E-85 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13675 3ef514068869db93d70f137222d38a24 386 Gene3D G3DSA:3.20.20.30 294 364 3.4E-99 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13675 3ef514068869db93d70f137222d38a24 386 Gene3D G3DSA:3.20.20.30 3 260 3.4E-99 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13675 3ef514068869db93d70f137222d38a24 386 SUPERFAMILY SSF51679 4 364 2.09E-91 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01300 10af915b6fb6d19a4e806bfc3b8e8bbb 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 57 1.8E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS01300 10af915b6fb6d19a4e806bfc3b8e8bbb 196 SUPERFAMILY SSF46689 4 74 1.28E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01300 10af915b6fb6d19a4e806bfc3b8e8bbb 196 SUPERFAMILY SSF48498 80 186 1.16E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS01300 10af915b6fb6d19a4e806bfc3b8e8bbb 196 Gene3D G3DSA:1.10.357.10 67 189 5.5E-19 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS01300 10af915b6fb6d19a4e806bfc3b8e8bbb 196 Gene3D G3DSA:1.10.10.60 2 65 3.1E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25925 9c5e60934e831beb5c7125899bbd20a6 191 Pfam PF02342 TerD domain 1 187 6.5E-85 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS25925 9c5e60934e831beb5c7125899bbd20a6 191 Gene3D G3DSA:2.60.60.30 18 185 1.3E-73 T 17-03-2017 SHXM_RS11560 046be43dabcbe4c2420b62e0b6b5b97e 281 Gene3D G3DSA:3.90.550.10 43 254 2.4E-28 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS11560 046be43dabcbe4c2420b62e0b6b5b97e 281 SUPERFAMILY SSF53448 42 253 1.13E-45 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS11560 046be43dabcbe4c2420b62e0b6b5b97e 281 Pfam PF00535 Glycosyl transferase family 2 43 205 1.7E-28 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS42310 c09916accffd7693e11c8c79bb7db088 411 Gene3D G3DSA:1.20.1250.20 229 400 2.6E-4 T 17-03-2017 SHXM_RS42310 c09916accffd7693e11c8c79bb7db088 411 Gene3D G3DSA:1.20.1250.20 33 198 2.5E-11 T 17-03-2017 SHXM_RS42310 c09916accffd7693e11c8c79bb7db088 411 Pfam PF07690 Major Facilitator Superfamily 26 353 4.6E-25 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS42310 c09916accffd7693e11c8c79bb7db088 411 SUPERFAMILY SSF103473 21 401 1.16E-32 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 Pfam PF01047 MarR family 42 97 5.8E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 SUPERFAMILY SSF46785 36 148 1.03E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 SMART SM00347 31 132 6.2E-17 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 Gene3D G3DSA:1.10.10.10 36 144 9.5E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 73 88 4.8E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 122 142 4.8E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 56 72 4.8E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS33190 3fbddee440176ac7c38169058c82fd53 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 92 108 4.8E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS03110 e37111666cb78ac8d0cf85406bcb8abb 302 Gene3D G3DSA:1.10.600.10 17 299 4.0E-22 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS03110 e37111666cb78ac8d0cf85406bcb8abb 302 SUPERFAMILY SSF48576 21 298 4.17E-27 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS03110 e37111666cb78ac8d0cf85406bcb8abb 302 Pfam PF00494 Squalene/phytoene synthase 35 285 5.5E-26 T 17-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 SHXM_RS25050 940323ba97bc98614e1723ab9cc3bab0 471 Pfam PF01425 Amidase 26 445 1.7E-105 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS25050 940323ba97bc98614e1723ab9cc3bab0 471 ProSitePatterns PS00571 Amidases signature. 151 182 - T 17-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 SHXM_RS25050 940323ba97bc98614e1723ab9cc3bab0 471 SUPERFAMILY SSF75304 9 465 4.06E-113 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS25050 940323ba97bc98614e1723ab9cc3bab0 471 Gene3D G3DSA:3.90.1300.10 13 463 4.9E-114 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS11475 fd8cb5bf80c1b2d246be36ed48ae0b6d 315 SUPERFAMILY SSF56601 23 297 1.62E-55 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS11475 fd8cb5bf80c1b2d246be36ed48ae0b6d 315 Gene3D G3DSA:3.40.710.10 30 294 3.1E-33 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS11475 fd8cb5bf80c1b2d246be36ed48ae0b6d 315 Pfam PF00144 Beta-lactamase 31 294 1.3E-21 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 Gene3D G3DSA:2.60.200.20 3 119 3.7E-23 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 191 214 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 Gene3D G3DSA:1.10.510.10 252 441 2.7E-35 T 17-03-2017 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 SMART SM00240 28 82 1.3E-12 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 SUPERFAMILY SSF56112 182 442 1.62E-62 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 SUPERFAMILY SSF49879 4 120 2.87E-21 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature. 305 317 - T 17-03-2017 IPR008266 Tyrosine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 Pfam PF00498 FHA domain 29 113 4.7E-20 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 Pfam PF00069 Protein kinase domain 185 399 7.5E-41 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS40200 0efb9fab7a70545fef12fe2e0d5c98f2 464 Gene3D G3DSA:3.30.200.20 182 251 3.1E-22 T 17-03-2017 SHXM_RS03320 e6725ed05ffa74103279f082623089ea 280 SUPERFAMILY SSF141571 179 275 2.35E-24 T 17-03-2017 SHXM_RS03320 e6725ed05ffa74103279f082623089ea 280 SUPERFAMILY SSF141571 65 100 2.35E-24 T 17-03-2017 SHXM_RS03320 e6725ed05ffa74103279f082623089ea 280 Pfam PF00805 Pentapeptide repeats (8 copies) 194 229 1.4E-12 T 17-03-2017 IPR001646 Pentapeptide repeat SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 Gene3D G3DSA:1.10.1740.10 12 82 2.2E-9 T 17-03-2017 SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 16 171 1.5E-16 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 SUPERFAMILY SSF88946 14 101 1.37E-9 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 Pfam PF08281 Sigma-70, region 4 115 161 4.0E-9 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 Gene3D G3DSA:1.10.10.10 108 172 1.8E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 Pfam PF04542 Sigma-70 region 2 19 58 5.6E-7 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08135 74bfe6679f36079941d764a0682f4a6f 179 SUPERFAMILY SSF88659 107 171 9.81E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS32835 019126c7808eacdd33bdef363ea73ebe 325 SMART SM00860 160 297 1.0E-5 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS32835 019126c7808eacdd33bdef363ea73ebe 325 Pfam PF14414 A nuclease of the HNH/ENDO VII superfamily with conserved WHH 96 133 2.1E-13 T 17-03-2017 IPR032869 WHH domain-containing protein SHXM_RS32835 019126c7808eacdd33bdef363ea73ebe 325 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 161 273 7.7E-9 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS32835 019126c7808eacdd33bdef363ea73ebe 325 Gene3D G3DSA:3.40.1580.10 161 192 5.4E-7 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS32835 019126c7808eacdd33bdef363ea73ebe 325 SUPERFAMILY SSF160631 160 298 1.96E-15 T 17-03-2017 SHXM_RS28745 bae5653ca90acd69daa9fd167493eb4b 124 Gene3D G3DSA:2.40.50.100 58 121 3.5E-21 T 17-03-2017 SHXM_RS28745 bae5653ca90acd69daa9fd167493eb4b 124 SUPERFAMILY SSF50331 7 121 6.56E-17 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS28745 bae5653ca90acd69daa9fd167493eb4b 124 Pfam PF00376 MerR family regulatory protein 1 35 5.5E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS28745 bae5653ca90acd69daa9fd167493eb4b 124 Gene3D G3DSA:1.10.1660.10 1 34 1.2E-5 T 17-03-2017 SHXM_RS28745 bae5653ca90acd69daa9fd167493eb4b 124 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 1 34 5.5E-8 T 17-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 SHXM_RS28745 bae5653ca90acd69daa9fd167493eb4b 124 Pfam PF03459 TOBE domain 59 119 2.3E-12 T 17-03-2017 IPR005116 Transport-associated OB, type 1 SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 Gene3D G3DSA:1.10.10.10 24 99 2.2E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 SUPERFAMILY SSF48452 100 263 3.22E-31 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 SUPERFAMILY SSF46894 2 76 1.11E-12 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 SMART SM01043 105 251 6.2E-43 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 Pfam PF00486 Transcriptional regulatory protein, C terminal 24 96 5.1E-9 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 Pfam PF03704 Bacterial transcriptional activator domain 105 251 4.8E-38 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS34820 d98ea6553be898df477285aeffbd529e 271 SMART SM00862 18 98 3.4E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS02945 5e5d04ce2dfa2a194f239d813a4ced72 224 SUPERFAMILY SSF89562 22 182 5.1E-44 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS02945 5e5d04ce2dfa2a194f239d813a4ced72 224 Gene3D G3DSA:3.50.30.40 21 180 1.0E-45 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS02945 5e5d04ce2dfa2a194f239d813a4ced72 224 Pfam PF03737 Demethylmenaquinone methyltransferase 25 172 7.1E-36 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS12840 4d65fe22262c905738e6070e8c33e864 167 Pfam PF00583 Acetyltransferase (GNAT) family 62 137 4.8E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS12840 4d65fe22262c905738e6070e8c33e864 167 SUPERFAMILY SSF55729 1 144 4.46E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12840 4d65fe22262c905738e6070e8c33e864 167 Gene3D G3DSA:3.40.630.30 2 157 7.1E-27 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 SMART SM00450 114 208 1.1E-14 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 Pfam PF03992 Antibiotic biosynthesis monooxygenase 6 71 7.2E-9 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 Gene3D G3DSA:3.30.70.900 3 72 1.2E-18 T 17-03-2017 SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 SUPERFAMILY SSF54909 6 75 1.57E-11 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 Gene3D G3DSA:3.40.250.10 113 209 4.9E-21 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 SUPERFAMILY SSF52821 113 210 6.55E-24 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS11125 269fecfe9a629a029e90aa5a9b2d011d 231 Pfam PF00581 Rhodanese-like domain 115 204 5.5E-11 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 Gene3D G3DSA:3.40.50.720 1 262 1.8E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 261 6.8E-44 T 17-03-2017 SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 1.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 1.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 1.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 SUPERFAMILY SSF51735 7 262 7.83E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 6.0E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 6.0E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 224 244 6.0E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 6.0E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 6.0E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS50755 15b714ad4384a6e3da4b151bb50daff6 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 6.0E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15090 46e160c1609eff0823171e0dac21af6b 176 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 63 91 8.5E-7 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS15090 46e160c1609eff0823171e0dac21af6b 176 SUPERFAMILY SSF50249 59 147 2.74E-8 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS06255 4b04d6af6187b59922fbae21b9c32a3b 383 Pfam PF13478 XdhC Rossmann domain 206 352 2.9E-41 T 17-03-2017 IPR027051 XdhC Rossmann domain SHXM_RS06255 4b04d6af6187b59922fbae21b9c32a3b 383 Pfam PF02625 XdhC and CoxI family 11 78 3.7E-23 T 17-03-2017 IPR003777 XdhC- CoxI SHXM_RS06255 4b04d6af6187b59922fbae21b9c32a3b 383 Pfam PF02625 XdhC and CoxI family 116 183 1.6E-18 T 17-03-2017 IPR003777 XdhC- CoxI SHXM_RS16815 f8791137279ca8eb036657d03bc5f6e0 146 SUPERFAMILY SSF54593 20 138 1.09E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS16815 f8791137279ca8eb036657d03bc5f6e0 146 Gene3D G3DSA:3.10.180.10 19 138 7.6E-28 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS16815 f8791137279ca8eb036657d03bc5f6e0 146 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 92 135 1.1E-6 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS28780 e96f7166e4a01848cf09038ee1690a01 221 Gene3D G3DSA:3.40.50.1000 83 218 5.3E-32 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS28780 e96f7166e4a01848cf09038ee1690a01 221 SUPERFAMILY SSF56784 2 216 1.13E-35 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS28780 e96f7166e4a01848cf09038ee1690a01 221 Pfam PF13419 Haloacid dehalogenase-like hydrolase 3 187 5.1E-17 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 SUPERFAMILY SSF46894 137 194 3.03E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 Pfam PF00196 Bacterial regulatory proteins, luxR family 148 194 2.1E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 Gene3D G3DSA:3.40.50.2300 2 150 9.6E-29 T 17-03-2017 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 SMART SM00421 147 209 3.0E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 SUPERFAMILY SSF52172 2 134 1.24E-21 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 SMART SM00448 1 120 7.0E-15 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 Gene3D G3DSA:1.10.10.10 151 214 9.9E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 Pfam PF00072 Response regulator receiver domain 3 108 2.5E-15 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 164 180 2.0E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 192 2.0E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS27215 ec054c8c1b642b1a5bf39f93846452f2 224 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 150 164 2.0E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS06410 4a9e67bf0fca5da296b717eaa8674ed6 476 Gene3D G3DSA:3.50.50.60 298 346 3.4E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06410 4a9e67bf0fca5da296b717eaa8674ed6 476 Gene3D G3DSA:3.50.50.60 8 192 3.4E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06410 4a9e67bf0fca5da296b717eaa8674ed6 476 SUPERFAMILY SSF51905 304 358 4.76E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06410 4a9e67bf0fca5da296b717eaa8674ed6 476 SUPERFAMILY SSF51905 4 190 4.76E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06410 4a9e67bf0fca5da296b717eaa8674ed6 476 Pfam PF12831 FAD dependent oxidoreductase 8 176 6.4E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 Gene3D G3DSA:3.40.50.720 193 298 2.1E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 SMART SM00829 11 362 0.0024 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 Pfam PF00107 Zinc-binding dehydrogenase 200 289 3.1E-18 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 SUPERFAMILY SSF50129 5 196 2.13E-48 T 17-03-2017 IPR011032 GroES-like SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 SUPERFAMILY SSF51735 162 328 8.79E-33 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 31 157 7.3E-20 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS02225 4b9ff904a0d404a50f7002f16914d00a 369 Gene3D G3DSA:3.90.180.10 4 192 9.6E-48 T 17-03-2017 IPR011032 GroES-like SHXM_RS15715 af9c82deca819a1f5cd2968897183492 430 Gene3D G3DSA:1.10.260.40 8 92 5.6E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15715 af9c82deca819a1f5cd2968897183492 430 SUPERFAMILY SSF47413 6 62 1.21E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15715 af9c82deca819a1f5cd2968897183492 430 SMART SM00530 11 66 8.2E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS15715 af9c82deca819a1f5cd2968897183492 430 Pfam PF13560 Helix-turn-helix domain 8 67 1.8E-11 T 17-03-2017 SHXM_RS41540 3d668b40c98f852948fd88c3701085b2 213 TIGRFAM TIGR04037 LLM_duo_CE1759: LLM-partnered FMN reductase, CE1759 family 3 197 1.1E-73 T 17-03-2017 IPR023932 Uncharacterised protein family, CE1759 SHXM_RS41540 3d668b40c98f852948fd88c3701085b2 213 Pfam PF03358 NADPH-dependent FMN reductase 1 151 1.2E-34 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS41540 3d668b40c98f852948fd88c3701085b2 213 Gene3D G3DSA:3.40.50.360 1 178 2.5E-33 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS41540 3d668b40c98f852948fd88c3701085b2 213 SUPERFAMILY SSF52218 1 166 2.55E-26 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS37215 d649d08208e1f4f80acebc0950d662f9 246 Pfam PF03591 AzlC protein 30 165 5.2E-28 T 17-03-2017 IPR011606 Branched-chain amino acid transport, permease SHXM_RS28075 f5cf9669eb9a2e89431ca53011ebfdd8 205 Gene3D G3DSA:3.40.630.30 4 136 6.1E-11 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS28075 f5cf9669eb9a2e89431ca53011ebfdd8 205 Pfam PF00583 Acetyltransferase (GNAT) family 65 139 1.2E-9 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS28075 f5cf9669eb9a2e89431ca53011ebfdd8 205 SUPERFAMILY SSF55729 5 141 2.27E-12 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS03280 4bc4d924a63e399a3a3da5e0e06708eb 316 Gene3D G3DSA:3.40.190.10 52 129 4.7E-6 T 17-03-2017 SHXM_RS03280 4bc4d924a63e399a3a3da5e0e06708eb 316 SMART SM00062 45 262 0.0013 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS03280 4bc4d924a63e399a3a3da5e0e06708eb 316 Pfam PF09084 NMT1/THI5 like 43 251 1.6E-21 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS03280 4bc4d924a63e399a3a3da5e0e06708eb 316 Gene3D G3DSA:3.40.190.10 130 241 1.7E-18 T 17-03-2017 SHXM_RS03280 4bc4d924a63e399a3a3da5e0e06708eb 316 SUPERFAMILY SSF53850 29 253 3.2E-33 T 17-03-2017 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 SUPERFAMILY SSF51905 174 354 6.07E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 Gene3D G3DSA:3.50.50.60 121 276 4.9E-18 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 113 131 1.8E-10 T 17-03-2017 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 1.8E-10 T 17-03-2017 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 173 191 1.8E-10 T 17-03-2017 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 SUPERFAMILY SSF51905 4 231 2.1E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 Gene3D G3DSA:3.50.50.60 277 355 1.5E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 Gene3D G3DSA:3.50.50.60 5 120 1.5E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29825 4dc0ef23123ea1f979ec796a4cd4a657 451 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 6 341 3.8E-41 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41880 fe4683335fd5f5e058c0441ccee536b4 156 TIGRFAM TIGR02605 CxxC_CxxC_SSSS: putative regulatory protein, FmdB family 1 45 1.9E-10 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS41880 fe4683335fd5f5e058c0441ccee536b4 156 SMART SM00834 1 39 2.3E-8 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS41880 fe4683335fd5f5e058c0441ccee536b4 156 Pfam PF09723 Zinc ribbon domain 1 37 1.2E-10 T 17-03-2017 IPR013429 Putative regulatory protein, FmdB, Zinc ribbon domain SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SMART SM00065 326 506 0.0082 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SUPERFAMILY SSF55781 417 507 2.4E-12 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SMART SM00331 524 746 7.0E-33 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Pfam PF17203 Single cache domain 3 36 169 2.2E-20 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Gene3D G3DSA:3.30.450.20 33 171 1.8E-37 T 17-03-2017 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SUPERFAMILY SSF55785 209 310 5.58E-8 T 17-03-2017 IPR000014 PAS domain SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 551 746 1.1E-45 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SMART SM00091 213 278 5.0E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Gene3D G3DSA:3.30.450.20 214 310 8.8E-9 T 17-03-2017 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SUPERFAMILY SSF81606 539 745 6.02E-9 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 SUPERFAMILY SSF103190 39 168 2.28E-26 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Pfam PF01590 GAF domain 418 496 3.3E-6 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Pfam PF13581 Histidine kinase-like ATPase domain 759 864 1.7E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS06615 0cd2ed54fb39fb6dd2ad58a5fa71874a 896 Gene3D G3DSA:3.30.450.40 332 504 1.8E-34 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 74 85 5.8E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 185 5.8E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 5.8E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 5.8E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 121 137 5.8E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 166 5.8E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 Gene3D G3DSA:3.40.50.720 10 251 1.8E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 250 1.2E-51 T 17-03-2017 SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 SUPERFAMILY SSF51735 10 251 3.81E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 127 135 1.6E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 147 166 1.6E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 74 85 1.6E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49625 fc06f19f5328a42f0464337065d28230 252 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 134 162 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS46005 a0aa33cfcd3183a289411ea3a4489515 230 Pfam PF00005 ABC transporter 36 117 2.5E-15 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46005 a0aa33cfcd3183a289411ea3a4489515 230 Gene3D G3DSA:3.40.50.300 22 118 1.4E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46005 a0aa33cfcd3183a289411ea3a4489515 230 SUPERFAMILY SSF52540 17 117 4.07E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38770 ee55f6dd25e4e82057997c0e206f57a5 453 Pfam PF03631 Virulence factor BrkB 56 310 5.8E-49 T 17-03-2017 IPR017039 Virulence factor BrkB SHXM_RS19440 8cdf891d2ae85cdceb2aa7dfc0e60ba8 375 Gene3D G3DSA:2.120.10.10 19 374 1.3E-74 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS19440 8cdf891d2ae85cdceb2aa7dfc0e60ba8 375 Pfam PF13088 BNR repeat-like domain 38 349 2.8E-27 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS19440 8cdf891d2ae85cdceb2aa7dfc0e60ba8 375 SUPERFAMILY SSF50939 13 374 2.1E-80 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS00755 ec6c09c27c4f798760fbaff1a4d6c1ba 327 Pfam PF00682 HMGL-like 25 297 3.9E-46 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS00755 ec6c09c27c4f798760fbaff1a4d6c1ba 327 SUPERFAMILY SSF51569 20 314 1.81E-69 T 17-03-2017 SHXM_RS00755 ec6c09c27c4f798760fbaff1a4d6c1ba 327 Gene3D G3DSA:3.20.20.70 23 310 2.1E-81 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS27670 fe7e7dc448090ed30781d24bee6e35ff 713 Pfam PF04234 CopC domain 51 147 2.8E-24 T 17-03-2017 IPR007348 CopC domain GO:0005507|GO:0042597|GO:0046688 SHXM_RS27670 fe7e7dc448090ed30781d24bee6e35ff 713 SUPERFAMILY SSF81296 50 147 3.15E-25 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS27670 fe7e7dc448090ed30781d24bee6e35ff 713 Gene3D G3DSA:2.60.40.1220 50 147 5.3E-29 T 17-03-2017 IPR014755 Copper resistance protein CopC/internalin, immunoglobulin-like SHXM_RS27670 fe7e7dc448090ed30781d24bee6e35ff 713 Pfam PF05425 Copper resistance protein D 359 440 8.6E-20 T 17-03-2017 IPR008457 Copper resistance protein D GO:0016021 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 SMART SM00448 2 115 6.9E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 Gene3D G3DSA:1.10.10.10 144 201 2.3E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 Gene3D G3DSA:3.40.50.2300 1 143 1.2E-35 T 17-03-2017 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 Pfam PF00196 Bacterial regulatory proteins, luxR family 140 195 1.3E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 Pfam PF00072 Response regulator receiver domain 4 116 3.7E-22 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 SUPERFAMILY SSF46894 124 201 5.78E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 171 3.8E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 183 3.8E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 141 155 3.8E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 SMART SM00421 138 195 5.0E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 ProSitePatterns PS00622 LuxR-type HTH domain signature. 155 182 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS22920 c2113bbfa6a3de1a840c779b2d19be10 201 SUPERFAMILY SSF52172 1 129 2.13E-28 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS43840 7b956dc17b27e3d526f213afc271ad2c 306 Gene3D G3DSA:1.10.3720.10 41 299 9.8E-41 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43840 7b956dc17b27e3d526f213afc271ad2c 306 SUPERFAMILY SSF161098 37 299 6.8E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43840 7b956dc17b27e3d526f213afc271ad2c 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 116 295 2.8E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 Pfam PF00571 CBS domain 158 210 6.0E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 Pfam PF00571 CBS domain 105 149 1.1E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 TIGRFAM TIGR01303 IMP_DH_rel_1: IMP dehydrogenase family protein 10 484 2.4E-271 T 17-03-2017 IPR005991 IMP dehydrogenase-related 1 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 SMART SM00116 164 212 11.0 T 17-03-2017 IPR000644 CBS domain SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 SMART SM00116 106 153 0.59 T 17-03-2017 IPR000644 CBS domain SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 Gene3D G3DSA:3.20.20.70 19 482 1.0E-134 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 PIRSF PIRSF000130 10 487 1.0E-144 T 17-03-2017 IPR005990 Inosine-5'-monophosphate dehydrogenase GO:0003938|GO:0006164|GO:0055114 KEGG: 00053+1.1.1.20|KEGG: 00230+1.1.1.205|KEGG: 00983+1.1.1.205|MetaCyc: PWY-5695|MetaCyc: PWY-6596|MetaCyc: PWY-7221|Reactome: R-HSA-73817 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 SUPERFAMILY SSF51412 210 481 1.44E-90 T 17-03-2017 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 SUPERFAMILY SSF51412 18 101 1.44E-90 T 17-03-2017 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 21 481 1.6E-100 T 17-03-2017 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 SMART SM01240 19 482 1.5E-191 T 17-03-2017 SHXM_RS12260 b129c59735e1d6aac19109910fdeb856 487 SUPERFAMILY SSF54631 101 211 4.8E-19 T 17-03-2017 SHXM_RS09940 c81778c4687f898ae4a8c99a2b64c145 353 SUPERFAMILY SSF46689 27 136 3.76E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09940 c81778c4687f898ae4a8c99a2b64c145 353 Pfam PF13358 DDE superfamily endonuclease 177 322 2.9E-30 T 17-03-2017 SHXM_RS09940 c81778c4687f898ae4a8c99a2b64c145 353 SUPERFAMILY SSF53098 211 335 6.53E-11 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09940 c81778c4687f898ae4a8c99a2b64c145 353 Gene3D G3DSA:3.30.420.10 213 334 5.1E-12 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09940 c81778c4687f898ae4a8c99a2b64c145 353 Pfam PF13565 Homeodomain-like domain 61 135 5.5E-16 T 17-03-2017 SHXM_RS49130 93414d9f739baab9bf2903f48dcb2aa2 91 Pfam PF13358 DDE superfamily endonuclease 4 59 4.5E-10 T 17-03-2017 SHXM_RS22265 5c49ec2cfba338ac6e8f658f7e459dae 336 Gene3D G3DSA:3.40.50.2300 172 312 1.4E-17 T 17-03-2017 SHXM_RS22265 5c49ec2cfba338ac6e8f658f7e459dae 336 Pfam PF13407 Periplasmic binding protein domain 56 297 8.9E-42 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS22265 5c49ec2cfba338ac6e8f658f7e459dae 336 SUPERFAMILY SSF53822 52 325 9.76E-55 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS22265 5c49ec2cfba338ac6e8f658f7e459dae 336 Gene3D G3DSA:3.40.50.2300 47 171 3.3E-32 T 17-03-2017 SHXM_RS37855 3844bdc5eb9ed3fc80706b8b312482bb 559 Gene3D G3DSA:3.50.50.60 203 333 9.4E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37855 3844bdc5eb9ed3fc80706b8b312482bb 559 Gene3D G3DSA:3.50.50.60 4 87 9.4E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37855 3844bdc5eb9ed3fc80706b8b312482bb 559 SUPERFAMILY SSF51905 4 324 5.01E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37855 3844bdc5eb9ed3fc80706b8b312482bb 559 SUPERFAMILY SSF51905 472 510 5.01E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37855 3844bdc5eb9ed3fc80706b8b312482bb 559 Pfam PF01593 Flavin containing amine oxidoreductase 16 509 4.1E-15 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS03525 8e0c016b1951c9e7035683b8da28305d 307 Gene3D G3DSA:1.10.3720.10 64 267 6.2E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03525 8e0c016b1951c9e7035683b8da28305d 307 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 3 45 6.4E-6 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS03525 8e0c016b1951c9e7035683b8da28305d 307 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 92 266 1.2E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03525 8e0c016b1951c9e7035683b8da28305d 307 SUPERFAMILY SSF161098 68 253 2.49E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 10 296 5.5E-71 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Gene3D G3DSA:3.10.580.10 339 457 1.4E-19 T 17-03-2017 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 TIGRFAM TIGR01137 cysta_beta: cystathionine beta-synthase 5 457 2.6E-211 T 17-03-2017 IPR005857 Cystathionine beta-synthase GO:0004122|GO:0005737|GO:0019343 KEGG: 00260+4.2.1.22|KEGG: 00270+4.2.1.22|MetaCyc: PWY-801 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 SUPERFAMILY SSF54631 339 457 1.26E-15 T 17-03-2017 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Pfam PF00571 CBS domain 339 394 5.4E-5 T 17-03-2017 IPR000644 CBS domain SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Pfam PF00571 CBS domain 409 457 1.7E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 SUPERFAMILY SSF53686 2 317 2.23E-99 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 SMART SM00116 339 395 0.092 T 17-03-2017 IPR000644 CBS domain SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 SMART SM00116 412 457 3.2 T 17-03-2017 IPR000644 CBS domain SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Gene3D G3DSA:3.40.50.1100 43 147 1.4E-39 T 17-03-2017 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 ProSitePatterns PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 33 51 - T 17-03-2017 IPR001216 Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site GO:0006535 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Gene3D G3DSA:3.40.50.1100 2 42 8.0E-73 T 17-03-2017 SHXM_RS24475 846f1867f391ddf4b715b7cf62ffe690 461 Gene3D G3DSA:3.40.50.1100 153 313 8.0E-73 T 17-03-2017 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 TIGRFAM TIGR01923 menE: O-succinylbenzoate-CoA ligase 32 492 7.0E-100 T 17-03-2017 IPR010192 2-succinylbenzoate--CoA ligase GO:0005524|GO:0008756|GO:0009234 KEGG: 00130+6.2.1.26|MetaCyc: PWY-5837 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 SUPERFAMILY SSF56801 9 499 1.44E-163 T 17-03-2017 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 Pfam PF00501 AMP-binding enzyme 12 403 5.3E-109 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 ProSitePatterns PS00455 Putative AMP-binding domain signature. 158 169 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 Gene3D G3DSA:3.40.50.980 164 318 1.0E-48 T 17-03-2017 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 Gene3D G3DSA:3.40.50.980 11 163 8.6E-41 T 17-03-2017 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 Pfam PF13193 AMP-binding enzyme C-terminal domain 412 487 3.1E-22 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 Gene3D G3DSA:2.30.38.10 324 397 1.6E-25 T 17-03-2017 SHXM_RS47045 2ebecff7e3cef35b3136f76d382bd60a 508 Gene3D G3DSA:3.30.300.30 398 495 5.5E-34 T 17-03-2017 SHXM_RS00235 da1f36ebcf7f0a328fb1396faefd91a1 88 SMART SM00530 16 71 1.1E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS00235 da1f36ebcf7f0a328fb1396faefd91a1 88 SUPERFAMILY SSF47413 12 74 2.4E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00235 da1f36ebcf7f0a328fb1396faefd91a1 88 Gene3D G3DSA:1.10.260.40 12 73 4.3E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00235 da1f36ebcf7f0a328fb1396faefd91a1 88 Pfam PF13560 Helix-turn-helix domain 13 70 4.1E-13 T 17-03-2017 SHXM_RS42915 986391b014cbda3f956175db0ee09fed 151 Gene3D G3DSA:1.20.1250.20 11 136 7.3E-11 T 17-03-2017 SHXM_RS42915 986391b014cbda3f956175db0ee09fed 151 SUPERFAMILY SSF103473 10 136 2.88E-11 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS35635 d8d3f08a50560d82f671dac6365c247d 278 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 43 56 1.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35635 d8d3f08a50560d82f671dac6365c247d 278 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 63 86 1.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35635 d8d3f08a50560d82f671dac6365c247d 278 Gene3D G3DSA:1.10.357.10 32 213 4.3E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS35635 d8d3f08a50560d82f671dac6365c247d 278 SUPERFAMILY SSF46689 32 108 4.64E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35635 d8d3f08a50560d82f671dac6365c247d 278 SUPERFAMILY SSF48498 107 212 2.59E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS35635 d8d3f08a50560d82f671dac6365c247d 278 Pfam PF00440 Bacterial regulatory proteins, tetR family 44 88 9.5E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 Pfam PF00072 Response regulator receiver domain 3 112 2.6E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 SUPERFAMILY SSF46894 119 220 3.68E-24 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 Pfam PF00486 Transcriptional regulatory protein, C terminal 145 219 4.9E-20 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 SMART SM00448 1 112 3.0E-36 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 Gene3D G3DSA:1.10.10.10 123 221 6.2E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 SMART SM00862 145 219 2.5E-20 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 Gene3D G3DSA:3.40.50.2300 1 119 2.3E-37 T 17-03-2017 SHXM_RS26110 c8cbfd9bdc6f99ccea5e73302faecdb4 226 SUPERFAMILY SSF52172 1 132 1.85E-37 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 ProSitePatterns PS00301 Translational (tr)-type guanine nucleotide-binding (G) domain signature. 78 93 - T 17-03-2017 IPR031157 Tr-type G domain, conserved site SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 Gene3D G3DSA:2.40.30.10 237 363 7.4E-21 T 17-03-2017 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 SUPERFAMILY SSF50465 331 432 2.01E-24 T 17-03-2017 IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 SUPERFAMILY SSF52540 24 247 7.47E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 SUPERFAMILY SSF50447 237 329 1.5E-19 T 17-03-2017 IPR009000 Translation protein, beta-barrel domain SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 Gene3D G3DSA:3.40.50.300 16 229 2.3E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 Pfam PF00009 Elongation factor Tu GTP binding domain 25 208 3.5E-40 T 17-03-2017 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 PRINTS PR00315 GTP-binding elongation factor signature 85 93 2.7E-12 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 PRINTS PR00315 GTP-binding elongation factor signature 105 115 2.7E-12 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 PRINTS PR00315 GTP-binding elongation factor signature 26 39 2.7E-12 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 PRINTS PR00315 GTP-binding elongation factor signature 121 132 2.7E-12 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 PRINTS PR00315 GTP-binding elongation factor signature 158 167 2.7E-12 T 17-03-2017 IPR000795 Transcription factor, GTP-binding domain GO:0003924|GO:0005525 SHXM_RS38725 d41ba3d36afbbfcd981c797b30303576 455 TIGRFAM TIGR02034 CysN: sulfate adenylyltransferase, large subunit 25 432 4.3E-165 T 17-03-2017 IPR011779 Sulphate adenylyltransferase, large subunit GO:0006790 KEGG: 00230+2.7.7.4|KEGG: 00261+2.7.7.4|KEGG: 00450+2.7.7.4|KEGG: 00920+2.7.7.4|MetaCyc: PWY-5278|MetaCyc: PWY-5340|MetaCyc: PWY-6683|MetaCyc: PWY-6932 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 Pfam PF07690 Major Facilitator Superfamily 43 435 1.0E-52 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 PRINTS PR01036 Tetracycline resistance protein TetB signature 227 245 1.4E-10 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 PRINTS PR01036 Tetracycline resistance protein TetB signature 132 152 1.4E-10 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 PRINTS PR01036 Tetracycline resistance protein TetB signature 162 186 1.4E-10 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 PRINTS PR01036 Tetracycline resistance protein TetB signature 42 66 1.4E-10 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 PRINTS PR01036 Tetracycline resistance protein TetB signature 426 445 1.4E-10 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 SUPERFAMILY SSF103473 491 515 2.35E-71 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 SUPERFAMILY SSF103473 273 445 2.35E-71 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 SUPERFAMILY SSF103473 25 220 2.35E-71 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 39 514 1.7E-84 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 Gene3D G3DSA:1.20.1250.20 492 518 3.2E-20 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 Gene3D G3DSA:1.20.1250.20 288 446 3.2E-20 T 17-03-2017 SHXM_RS30250 c9f5b48235464923bdd5e3e623bcf495 543 Gene3D G3DSA:1.20.1250.20 40 219 9.9E-34 T 17-03-2017 SHXM_RS39515 264408637b0e5c6cfc5a03ca9e858058 364 SUPERFAMILY SSF56601 30 341 1.3E-52 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39515 264408637b0e5c6cfc5a03ca9e858058 364 Gene3D G3DSA:3.40.710.10 32 348 3.1E-56 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39515 264408637b0e5c6cfc5a03ca9e858058 364 Pfam PF00144 Beta-lactamase 40 341 1.2E-51 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS18065 6c90a93361258c52a9fcd5a435e366c5 122 Gene3D G3DSA:1.25.40.10 3 114 8.5E-16 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS18065 6c90a93361258c52a9fcd5a435e366c5 122 SUPERFAMILY SSF48452 6 109 1.24E-16 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS18065 6c90a93361258c52a9fcd5a435e366c5 122 Pfam PF14559 Tetratricopeptide repeat 19 77 1.1E-6 T 17-03-2017 SHXM_RS26495 ba3b7dad7d874728fe84c5b18a74d89d 233 PIRSF PIRSF006324 2 232 2.0E-50 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS26495 ba3b7dad7d874728fe84c5b18a74d89d 233 Pfam PF01810 LysE type translocator 17 230 6.6E-42 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS19790 410c903262499cd9833d00c2337d9977 445 Pfam PF13439 Glycosyltransferase Family 4 41 243 6.8E-27 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS19790 410c903262499cd9833d00c2337d9977 445 Gene3D G3DSA:3.40.50.2000 226 414 1.6E-28 T 17-03-2017 SHXM_RS19790 410c903262499cd9833d00c2337d9977 445 Pfam PF00534 Glycosyl transferases group 1 258 414 6.6E-30 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS19790 410c903262499cd9833d00c2337d9977 445 SUPERFAMILY SSF53756 29 436 4.59E-82 T 17-03-2017 SHXM_RS07765 ce4b3f6a6769147f31434cd4ec49ff26 449 Pfam PF01547 Bacterial extracellular solute-binding protein 50 341 5.8E-47 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS07765 ce4b3f6a6769147f31434cd4ec49ff26 449 SUPERFAMILY SSF53850 23 446 1.39E-71 T 17-03-2017 SHXM_RS07765 ce4b3f6a6769147f31434cd4ec49ff26 449 Gene3D G3DSA:3.40.190.10 171 366 1.4E-46 T 17-03-2017 SHXM_RS07765 ce4b3f6a6769147f31434cd4ec49ff26 449 Gene3D G3DSA:3.40.190.10 46 170 5.8E-20 T 17-03-2017 SHXM_RS35645 e3f233c4d89ad3f24fd7b13dcb81aa87 458 Pfam PF01547 Bacterial extracellular solute-binding protein 54 362 1.7E-33 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS35645 e3f233c4d89ad3f24fd7b13dcb81aa87 458 Gene3D G3DSA:3.40.190.10 334 396 1.6E-39 T 17-03-2017 SHXM_RS35645 e3f233c4d89ad3f24fd7b13dcb81aa87 458 Gene3D G3DSA:3.40.190.10 29 160 1.6E-39 T 17-03-2017 SHXM_RS35645 e3f233c4d89ad3f24fd7b13dcb81aa87 458 SUPERFAMILY SSF53850 20 446 4.25E-80 T 17-03-2017 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 Pfam PF00196 Bacterial regulatory proteins, luxR family 57 112 8.5E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 SMART SM00421 55 112 9.4E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 Gene3D G3DSA:1.10.10.10 33 119 6.8E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 88 100 5.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 72 88 5.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 58 72 5.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 SUPERFAMILY SSF46894 41 119 2.99E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 Gene3D G3DSA:3.40.50.2300 5 32 6.0E-4 T 17-03-2017 SHXM_RS26645 3f5dddd59cf534ef73207d4e2157a529 140 ProSitePatterns PS00622 LuxR-type HTH domain signature. 72 99 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 SUPERFAMILY SSF46894 850 915 7.48E-15 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Gene3D G3DSA:1.25.40.10 677 842 2.4E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Gene3D G3DSA:1.25.40.10 564 637 2.4E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 878 894 7.3E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 864 878 7.3E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 894 906 7.3E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 SUPERFAMILY SSF48452 684 827 1.1E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 SUPERFAMILY SSF48452 613 639 1.1E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 SUPERFAMILY SSF52540 38 245 1.55E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 ProSitePatterns PS00622 LuxR-type HTH domain signature. 878 905 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 SMART SM00421 861 918 1.4E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Gene3D G3DSA:1.10.10.10 855 914 3.8E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Pfam PF00196 Bacterial regulatory proteins, luxR family 863 914 7.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Pfam PF13191 AAA ATPase domain 41 173 3.3E-12 T 17-03-2017 SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Gene3D G3DSA:3.40.50.300 131 191 4.3E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42810 aec136a729c2b56914dcbef4cec0b3cb 926 Gene3D G3DSA:3.40.50.300 38 94 4.3E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42895 da50783534e232795752c150da27dbca 266 SUPERFAMILY SSF53474 7 261 4.42E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42895 da50783534e232795752c150da27dbca 266 Pfam PF12146 Serine aminopeptidase, S33 50 248 3.4E-19 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS42895 da50783534e232795752c150da27dbca 266 Gene3D G3DSA:3.40.50.1820 6 262 3.2E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32450 6dc2b40a9cc8553c79bb41e3b5024ad1 207 Gene3D G3DSA:3.40.630.30 3 190 1.1E-56 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS32450 6dc2b40a9cc8553c79bb41e3b5024ad1 207 SUPERFAMILY SSF55729 8 184 2.71E-40 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS32450 6dc2b40a9cc8553c79bb41e3b5024ad1 207 Pfam PF13302 Acetyltransferase (GNAT) domain 15 161 1.2E-16 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS11235 0db89225d54f558aabaad8de41a2b907 300 Pfam PF00753 Metallo-beta-lactamase superfamily 61 273 4.2E-31 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS11235 0db89225d54f558aabaad8de41a2b907 300 Gene3D G3DSA:3.60.15.10 1 292 4.0E-50 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS11235 0db89225d54f558aabaad8de41a2b907 300 SMART SM00849 59 273 2.0E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS11235 0db89225d54f558aabaad8de41a2b907 300 SUPERFAMILY SSF56281 54 289 4.19E-40 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 342 362 7.3E-9 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 465 481 7.3E-9 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 378 394 7.3E-9 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 79 126 4.8E-18 T 17-03-2017 IPR011096 FTP domain SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 239 387 3.6E-48 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 SUPERFAMILY SSF55486 237 563 3.48E-72 T 17-03-2017 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 Gene3D G3DSA:1.10.390.10 395 563 5.4E-46 T 17-03-2017 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 390 563 6.1E-46 T 17-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 SHXM_RS40125 3578ed736dd8335e364840359bbb464c 564 Gene3D G3DSA:3.10.170.10 238 390 2.7E-44 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Hamap MF_00031 Holliday junction ATP-dependent DNA helicase RuvA [ruvA]. 1 203 27.082 T 17-03-2017 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Pfam PF01330 RuvA N terminal domain 1 61 1.5E-17 T 17-03-2017 IPR013849 DNA helicase, Holliday junction RuvA type, domain I, bacterial GO:0005524|GO:0006281|GO:0006310|GO:0009378 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Gene3D G3DSA:1.10.150.20 66 133 3.0E-26 T 17-03-2017 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 SMART SM00278 107 126 0.065 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 SMART SM00278 72 91 50.0 T 17-03-2017 IPR003583 Helix-hairpin-helix DNA-binding motif, class 1 GO:0003677|GO:0006281 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 SUPERFAMILY SSF50249 1 62 2.34E-13 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 SUPERFAMILY SSF47781 65 132 1.06E-18 T 17-03-2017 IPR010994 RuvA domain 2-like SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Gene3D G3DSA:2.40.50.140 1 64 3.3E-21 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Pfam PF14520 Helix-hairpin-helix domain 71 129 1.3E-15 T 17-03-2017 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 SUPERFAMILY SSF46929 149 204 4.97E-8 T 17-03-2017 IPR011114 DNA helicase, Holliday junction RuvA type, domain III, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 TIGRFAM TIGR00084 ruvA: Holliday junction DNA helicase RuvA 1 183 1.1E-37 T 17-03-2017 IPR000085 Bacterial DNA recombination protein RuvA GO:0003678|GO:0006281|GO:0006310 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Pfam PF07499 RuvA, C-terminal domain 150 202 5.4E-10 T 17-03-2017 IPR011114 DNA helicase, Holliday junction RuvA type, domain III, C-terminal GO:0005524|GO:0006281|GO:0006310|GO:0009378|GO:0009379 SHXM_RS12545 17b7542eaf9f21cd85479a50a691d68c 206 Gene3D G3DSA:1.10.8.10 144 206 1.5E-11 T 17-03-2017 SHXM_RS12930 e423d1f6b0d5e8f859ba11ab8dcf3f7a 196 SUPERFAMILY SSF50475 7 118 7.36E-11 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS12930 e423d1f6b0d5e8f859ba11ab8dcf3f7a 196 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 9 102 5.8E-12 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS12930 e423d1f6b0d5e8f859ba11ab8dcf3f7a 196 Gene3D G3DSA:2.30.110.10 3 132 3.2E-15 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 Gene3D G3DSA:3.40.50.300 801 952 3.5E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 Pfam PF12419 SNF2 Helicase protein 326 461 5.1E-41 T 17-03-2017 IPR022138 Helicase SWF/SNF-related SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 SUPERFAMILY SSF52540 728 973 3.59E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 Pfam PF00271 Helicase conserved C-terminal domain 806 917 3.3E-17 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 SMART SM00490 835 917 1.0E-23 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 SUPERFAMILY SSF52540 497 721 8.55E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 Gene3D G3DSA:3.40.50.300 506 675 3.5E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 Pfam PF00176 SNF2 family N-terminal domain 530 789 1.3E-47 T 17-03-2017 IPR000330 SNF2-related, N-terminal domain GO:0005524 SHXM_RS45100 88c8e94bb6028eb1d57c2e994f72a5a0 978 SMART SM00487 507 693 2.4E-27 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS04340 34e5c15409f0a1425ae958da839a46f3 222 SUPERFAMILY SSF51735 44 221 1.15E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04340 34e5c15409f0a1425ae958da839a46f3 222 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 44 221 1.9E-56 T 17-03-2017 SHXM_RS04340 34e5c15409f0a1425ae958da839a46f3 222 Pfam PF08659 KR domain 44 222 2.0E-60 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS04340 34e5c15409f0a1425ae958da839a46f3 222 Gene3D G3DSA:3.40.50.720 44 221 1.4E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19760 1c90a263623148deb575dd4818599170 292 Pfam PF01520 N-acetylmuramoyl-L-alanine amidase 76 287 7.0E-35 T 17-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 SHXM_RS19760 1c90a263623148deb575dd4818599170 292 SMART SM00646 159 287 1.5E-14 T 17-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 SHXM_RS19760 1c90a263623148deb575dd4818599170 292 Gene3D G3DSA:3.40.630.40 73 291 4.6E-36 T 17-03-2017 IPR002508 N-acetylmuramoyl-L-alanine amidase, catalytic domain GO:0008745|GO:0009253 SHXM_RS19760 1c90a263623148deb575dd4818599170 292 SUPERFAMILY SSF53187 73 291 1.32E-31 T 17-03-2017 SHXM_RS04460 50b48576f9055fca91feddf14ed78a4b 455 Gene3D G3DSA:1.20.1250.20 28 215 6.4E-26 T 17-03-2017 SHXM_RS04460 50b48576f9055fca91feddf14ed78a4b 455 Gene3D G3DSA:1.20.1250.20 268 444 9.7E-16 T 17-03-2017 SHXM_RS04460 50b48576f9055fca91feddf14ed78a4b 455 ProSitePatterns PS00217 Sugar transport proteins signature 2. 126 151 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS04460 50b48576f9055fca91feddf14ed78a4b 455 SUPERFAMILY SSF103473 10 447 1.57E-71 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04460 50b48576f9055fca91feddf14ed78a4b 455 Pfam PF00083 Sugar (and other) transporter 32 451 2.5E-61 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS48920 21ac7f26e2215b2e7dee5c5e00fc8f73 259 Pfam PF00378 Enoyl-CoA hydratase/isomerase 20 238 1.6E-49 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS48920 21ac7f26e2215b2e7dee5c5e00fc8f73 259 Gene3D G3DSA:3.90.226.10 7 238 1.8E-61 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS48920 21ac7f26e2215b2e7dee5c5e00fc8f73 259 SUPERFAMILY SSF52096 19 253 9.79E-62 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47470 a1da761a7201bc56614ad16085cb4f2f 134 Pfam PF12680 SnoaL-like domain 13 110 9.2E-10 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS47470 a1da761a7201bc56614ad16085cb4f2f 134 Gene3D G3DSA:3.10.450.50 1 120 4.7E-13 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS47470 a1da761a7201bc56614ad16085cb4f2f 134 SUPERFAMILY SSF54427 6 122 6.81E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS45970 5fca877e827b00af708f81f5164e9725 311 Gene3D G3DSA:3.30.2010.10 109 179 8.5E-15 T 17-03-2017 SHXM_RS45970 5fca877e827b00af708f81f5164e9725 311 Pfam PF01435 Peptidase family M48 112 185 4.7E-12 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS40705 ff6f4cb43ca6d1a6bbb273e2e1cea098 100 Gene3D G3DSA:3.30.70.900 2 89 1.3E-25 T 17-03-2017 SHXM_RS40705 ff6f4cb43ca6d1a6bbb273e2e1cea098 100 Pfam PF03992 Antibiotic biosynthesis monooxygenase 3 75 2.1E-20 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS40705 ff6f4cb43ca6d1a6bbb273e2e1cea098 100 SUPERFAMILY SSF54909 3 89 6.37E-24 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS46135 c06ecd090a80fa084ee2f9c147a781e1 627 SUPERFAMILY SSF75005 90 315 1.7E-20 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46135 c06ecd090a80fa084ee2f9c147a781e1 627 SUPERFAMILY SSF75005 329 616 5.44E-75 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46135 c06ecd090a80fa084ee2f9c147a781e1 627 Gene3D G3DSA:2.115.10.20 329 615 2.4E-80 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46135 c06ecd090a80fa084ee2f9c147a781e1 627 Gene3D G3DSA:2.115.10.20 94 288 1.0E-16 T 17-03-2017 IPR023296 Glycosyl hydrolase, five-bladed beta-propellor domain SHXM_RS46135 c06ecd090a80fa084ee2f9c147a781e1 627 Pfam PF04616 Glycosyl hydrolases family 43 329 600 2.7E-62 T 17-03-2017 IPR006710 Glycoside hydrolase, family 43 GO:0004553|GO:0005975 SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 Gene3D G3DSA:3.40.50.720 178 262 3.0E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 SUPERFAMILY SSF51735 143 261 7.76E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 SUPERFAMILY SSF50129 30 177 6.85E-38 T 17-03-2017 IPR011032 GroES-like SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 Gene3D G3DSA:3.90.180.10 30 177 1.7E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 56 115 1.5E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 Pfam PF13602 Zinc-binding dehydrogenase 214 335 5.2E-27 T 17-03-2017 SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 172 193 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS41355 372860ce5070986040e260b3b783d95b 338 SMART SM00829 39 335 4.3E-45 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 116 136 7.2E-6 T 17-03-2017 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 410 429 7.2E-6 T 17-03-2017 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 146 170 7.2E-6 T 17-03-2017 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 PRINTS PR01036 Tetracycline resistance protein TetB signature 26 50 7.2E-6 T 17-03-2017 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 SUPERFAMILY SSF103473 10 202 9.55E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 SUPERFAMILY SSF103473 257 429 9.55E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 SUPERFAMILY SSF103473 472 498 9.55E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 Pfam PF07690 Major Facilitator Superfamily 27 419 7.3E-46 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 ProSitePatterns PS00217 Sugar transport proteins signature 2. 118 143 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 Gene3D G3DSA:1.20.1250.20 23 200 1.1E-28 T 17-03-2017 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 Gene3D G3DSA:1.20.1250.20 473 497 8.7E-17 T 17-03-2017 SHXM_RS11945 6b925ef3d9f61808173817908c86010f 502 Gene3D G3DSA:1.20.1250.20 272 430 8.7E-17 T 17-03-2017 SHXM_RS35405 d8a32fcfe2d60d28a0245bff39635d46 101 Gene3D G3DSA:3.30.280.10 1 99 5.5E-42 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35405 d8a32fcfe2d60d28a0245bff39635d46 101 Pfam PF00547 Urease, gamma subunit 1 99 6.0E-42 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35405 d8a32fcfe2d60d28a0245bff39635d46 101 SUPERFAMILY SSF54111 1 99 3.27E-38 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35405 d8a32fcfe2d60d28a0245bff39635d46 101 ProDom PD002319 SUBUNIT GAMMA HYDROLASE UREASE UREA AMIDOHYDROLASE UREASE ALPHA GAMMA/BETA METAL-BINDING 9 99 6.0E-22 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35405 d8a32fcfe2d60d28a0245bff39635d46 101 TIGRFAM TIGR00193 urease_gam: urease, gamma subunit 1 100 5.6E-38 T 17-03-2017 IPR002026 Urease, gamma/gamma-beta subunit GO:0016151|GO:0043419 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 Gene3D G3DSA:1.10.10.10 23 110 3.9E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 SUPERFAMILY SSF46785 9 102 3.63E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 SMART SM00418 22 101 4.0E-12 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 57 72 7.5E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 24 39 7.5E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 72 87 7.5E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26360 a743063f0e3f75c0a27c81d74b0bb39f 115 Pfam PF12840 Helix-turn-helix domain 22 80 1.1E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43405 a15c14aba52e8c73796f5e936c701753 138 SUPERFAMILY SSF53062 10 135 5.76E-29 T 17-03-2017 IPR004701 Phosphotransferase system, mannose-type IIA component GO:0009401|GO:0016021 SHXM_RS43405 a15c14aba52e8c73796f5e936c701753 138 Gene3D G3DSA:3.40.50.510 7 137 3.4E-41 T 17-03-2017 IPR004701 Phosphotransferase system, mannose-type IIA component GO:0009401|GO:0016021 SHXM_RS43405 a15c14aba52e8c73796f5e936c701753 138 Pfam PF03610 PTS system fructose IIA component 11 125 2.7E-25 T 17-03-2017 IPR004701 Phosphotransferase system, mannose-type IIA component GO:0009401|GO:0016021 SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 91 4.6E-8 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 SUPERFAMILY SSF51735 114 261 2.37E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 SUPERFAMILY SSF50129 2 148 9.59E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 SMART SM00829 10 318 4.6E-13 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 Gene3D G3DSA:3.40.50.720 147 254 9.6E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 Pfam PF13602 Zinc-binding dehydrogenase 185 318 2.1E-16 T 17-03-2017 SHXM_RS03125 67c6b65889e64ab5c38eb82e32871437 320 Gene3D G3DSA:3.90.180.10 2 146 1.5E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS41010 c0ec11426cd1557e722771367a21c1d5 96 SUPERFAMILY SSF51679 1 96 1.09E-14 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS41010 c0ec11426cd1557e722771367a21c1d5 96 Pfam PF00296 Luciferase-like monooxygenase 14 95 3.9E-9 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS41010 c0ec11426cd1557e722771367a21c1d5 96 Gene3D G3DSA:3.20.20.30 1 96 7.6E-16 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 SUPERFAMILY SSF88659 107 163 1.36E-11 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 Gene3D G3DSA:1.10.1740.10 4 89 3.0E-12 T 17-03-2017 SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 Gene3D G3DSA:1.10.10.10 106 163 4.1E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 Pfam PF04542 Sigma-70 region 2 11 76 7.9E-7 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 Pfam PF08281 Sigma-70, region 4 108 158 4.8E-10 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 SUPERFAMILY SSF88946 4 82 3.92E-12 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07030 38c67fca29741cd14071941179b0fefd 198 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 5 161 1.5E-15 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08500 41e7f2a62bcf4da23169d6c8c5e1304b 157 Gene3D G3DSA:3.90.1720.10 36 155 4.9E-38 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS08500 41e7f2a62bcf4da23169d6c8c5e1304b 157 SUPERFAMILY SSF54001 41 152 3.19E-35 T 17-03-2017 SHXM_RS08500 41e7f2a62bcf4da23169d6c8c5e1304b 157 Pfam PF00877 NlpC/P60 family 56 142 9.1E-24 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS22415 c74f3c334f1da6a9e8c41e831890b975 318 Pfam PF14100 Methane oxygenase PmoA 15 312 3.2E-79 T 17-03-2017 IPR029475 Methane oxygenase PmoA SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 Pfam PF01593 Flavin containing amine oxidoreductase 22 479 5.3E-44 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 SUPERFAMILY SSF54373 317 430 7.06E-24 T 17-03-2017 SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 Gene3D G3DSA:3.90.660.20 245 430 4.5E-31 T 17-03-2017 IPR027418 Protoporphyrinogen oxidase, C-terminal domain KEGG: 00860+1.3.3.4|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 SUPERFAMILY SSF51905 14 333 1.89E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 SUPERFAMILY SSF51905 447 479 1.89E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 Gene3D G3DSA:3.40.50.720 12 54 1.2E-9 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 Gene3D G3DSA:1.10.3110.10 115 208 3.8E-20 T 17-03-2017 SHXM_RS38285 6b55cd2d2b991c3cbf4f6f4450f5b05d 496 TIGRFAM TIGR00562 proto_IX_ox: protoporphyrinogen oxidase 13 479 9.3E-58 T 17-03-2017 IPR004572 Protoporphyrinogen oxidase GO:0004729|GO:0006779|GO:0055114 KEGG: 00860+1.3.3.4|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS17555 bdf99f45259d51a288d4418eb65d9f8c 308 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 266 300 2.2E-4 T 17-03-2017 IPR019931 LPXTG cell wall anchor domain SHXM_RS44050 335f28eb4f72080f84913bb67304dc80 167 Pfam PF00355 Rieske [2Fe-2S] domain 75 153 1.4E-17 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS44050 335f28eb4f72080f84913bb67304dc80 167 SUPERFAMILY SSF50022 75 166 4.71E-27 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS44050 335f28eb4f72080f84913bb67304dc80 167 Gene3D G3DSA:2.102.10.10 11 165 7.8E-30 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS44050 335f28eb4f72080f84913bb67304dc80 167 PRINTS PR00162 Rieske 2Fe-2S subunit signature 127 139 1.0E-6 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS44050 335f28eb4f72080f84913bb67304dc80 167 PRINTS PR00162 Rieske 2Fe-2S subunit signature 107 118 1.0E-6 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS44050 335f28eb4f72080f84913bb67304dc80 167 PRINTS PR00162 Rieske 2Fe-2S subunit signature 140 152 1.0E-6 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS43805 e8c095ccdae515436672518e5c283c60 197 SUPERFAMILY SSF52540 17 191 4.02E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43805 e8c095ccdae515436672518e5c283c60 197 Pfam PF03029 Conserved hypothetical ATP binding protein 23 141 6.0E-23 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS43805 e8c095ccdae515436672518e5c283c60 197 Gene3D G3DSA:3.40.50.300 18 189 1.2E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS09045 712a8b1dc7e6cc72db74f2f9e9277b61 504 Pfam PF14690 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 35 77 5.3E-11 T 17-03-2017 IPR029261 Transposase IS204/IS1001/IS1096/IS1165, zinc-finger SHXM_RS09045 712a8b1dc7e6cc72db74f2f9e9277b61 504 Pfam PF01610 Transposase 376 501 7.3E-11 T 17-03-2017 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SHXM_RS09045 712a8b1dc7e6cc72db74f2f9e9277b61 504 Pfam PF01610 Transposase 153 240 2.7E-18 T 17-03-2017 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SHXM_RS03910 23da8e6cebbee9fd22d9e246c6dd5ed7 328 SUPERFAMILY SSF51735 106 288 1.81E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03910 23da8e6cebbee9fd22d9e246c6dd5ed7 328 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 114 287 6.5E-43 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS03910 23da8e6cebbee9fd22d9e246c6dd5ed7 328 Gene3D G3DSA:3.40.50.720 18 120 2.7E-6 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03910 23da8e6cebbee9fd22d9e246c6dd5ed7 328 SUPERFAMILY SSF52283 17 141 3.4E-10 T 17-03-2017 SHXM_RS03910 23da8e6cebbee9fd22d9e246c6dd5ed7 328 Gene3D G3DSA:3.40.50.720 121 288 3.2E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05355 4c3fdd28f520fc6b56ece55dac4be39f 172 Pfam PF00550 Phosphopantetheine attachment site 108 172 4.6E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05355 4c3fdd28f520fc6b56ece55dac4be39f 172 SMART SM00823 Phosphopantetheine attachment site 106 172 5.9E-23 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05355 4c3fdd28f520fc6b56ece55dac4be39f 172 SUPERFAMILY SSF47336 100 172 3.27E-20 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05355 4c3fdd28f520fc6b56ece55dac4be39f 172 Gene3D G3DSA:1.10.1200.10 103 172 2.2E-21 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS05355 4c3fdd28f520fc6b56ece55dac4be39f 172 SMART SM01294 107 172 8.3E-5 T 17-03-2017 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 SUPERFAMILY SSF54506 9 138 5.61E-28 T 17-03-2017 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 Pfam PF01678 Diaminopimelate epimerase 157 271 1.3E-20 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 Pfam PF01678 Diaminopimelate epimerase 9 137 3.7E-27 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 Gene3D G3DSA:3.10.310.10 134 267 3.6E-36 T 17-03-2017 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 SUPERFAMILY SSF54506 145 278 7.85E-31 T 17-03-2017 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 Gene3D G3DSA:3.10.310.10 8 133 1.6E-34 T 17-03-2017 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 ProSitePatterns PS01326 Diaminopimelate epimerase signature. 77 91 - T 17-03-2017 IPR018510 Diaminopimelate epimerase, active site GO:0005737|GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 Hamap MF_00197 Diaminopimelate epimerase [dapF]. 7 280 28.382 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS09730 11084b31615d3d53d9622d0a74277f64 300 TIGRFAM TIGR00652 DapF: diaminopimelate epimerase 8 278 7.1E-59 T 17-03-2017 IPR001653 Diaminopimelate epimerase, DapF GO:0008837|GO:0009089 KEGG: 00300+5.1.1.7|MetaCyc: PWY-2941|MetaCyc: PWY-5097 SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 Gene3D G3DSA:3.30.70.890 167 293 3.7E-25 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 TIGRFAM TIGR00154 ispE: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase 5 278 6.6E-50 T 17-03-2017 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 SUPERFAMILY SSF55060 167 293 9.83E-22 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 PIRSF PIRSF010376 3 304 2.2E-74 T 17-03-2017 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 Hamap MF_00061 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [ispE]. 5 298 29.67 T 17-03-2017 IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase GO:0016114|GO:0050515 KEGG: 00710+2.7.1.14|KEGG: 00900+2.7.1.148|MetaCyc: PWY-7560 SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 Pfam PF00288 GHMP kinases N terminal domain 89 147 1.7E-6 T 17-03-2017 IPR006204 GHMP kinase N-terminal domain GO:0005524 SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 Gene3D G3DSA:3.30.230.10 6 162 7.7E-47 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 Pfam PF08544 GHMP kinases C terminal 212 288 8.2E-8 T 17-03-2017 IPR013750 GHMP kinase, C-terminal domain SHXM_RS32685 7de1382f6ab02e92e16cf67087645ba0 308 SUPERFAMILY SSF54211 4 161 1.52E-40 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS43910 1396b01067424e5c9c1b21cd107da1ee 202 PIRSF PIRSF000847 11 202 1.7E-44 T 17-03-2017 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668 SHXM_RS43910 1396b01067424e5c9c1b21cd107da1ee 202 Pfam PF01066 CDP-alcohol phosphatidyltransferase 16 85 1.7E-14 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS43910 1396b01067424e5c9c1b21cd107da1ee 202 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 63 85 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS41670 6938bc4a4a1cfad35801a44a8759808f 395 Gene3D G3DSA:3.40.710.10 46 364 3.1E-67 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS41670 6938bc4a4a1cfad35801a44a8759808f 395 Pfam PF00144 Beta-lactamase 52 378 4.5E-58 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS41670 6938bc4a4a1cfad35801a44a8759808f 395 SUPERFAMILY SSF56601 45 358 6.66E-69 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS04250 8b7d3e635f09044d0be16a21713b6518 253 Pfam PF00583 Acetyltransferase (GNAT) family 165 240 4.7E-10 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS04250 8b7d3e635f09044d0be16a21713b6518 253 SUPERFAMILY SSF55729 160 243 1.42E-15 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS04250 8b7d3e635f09044d0be16a21713b6518 253 Gene3D G3DSA:3.40.630.30 165 241 2.2E-13 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS23025 6353aa02c46a113ce69bf9c7e09b46f9 272 SUPERFAMILY SSF56214 144 253 1.02E-19 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS23025 6353aa02c46a113ce69bf9c7e09b46f9 272 Gene3D G3DSA:3.90.470.20 44 150 9.5E-24 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS23025 6353aa02c46a113ce69bf9c7e09b46f9 272 Gene3D G3DSA:3.90.470.20 151 250 3.5E-13 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS23025 6353aa02c46a113ce69bf9c7e09b46f9 272 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 144 209 1.5E-10 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS23025 6353aa02c46a113ce69bf9c7e09b46f9 272 SUPERFAMILY SSF56214 39 137 1.05E-17 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS35990 8aea275d3aaa5c4416109cb245f7ee2f 324 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 124 322 9.0E-40 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35990 8aea275d3aaa5c4416109cb245f7ee2f 324 SUPERFAMILY SSF161098 99 310 4.3E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35990 8aea275d3aaa5c4416109cb245f7ee2f 324 Gene3D G3DSA:1.10.3720.10 97 319 1.3E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00101 Aspartate carbamoyltransferase signature 291 305 2.6E-30 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00101 Aspartate carbamoyltransferase signature 267 272 2.6E-30 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00101 Aspartate carbamoyltransferase signature 134 151 2.6E-30 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00101 Aspartate carbamoyltransferase signature 226 235 2.6E-30 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00101 Aspartate carbamoyltransferase signature 77 86 2.6E-30 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00101 Aspartate carbamoyltransferase signature 39 61 2.6E-30 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 49 68 3.6E-19 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 263 272 3.6E-19 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 275 298 3.6E-19 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 PRINTS PR00100 Aspartate/ornithine carbamoyltransferase superfamily signature 135 146 3.6E-19 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 ProSitePatterns PS00097 Aspartate and ornithine carbamoyltransferases signature. 49 56 - T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 Hamap MF_00001 Aspartate carbamoyltransferase [pyrB]. 2 312 41.319 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 Gene3D G3DSA:3.40.50.1370 2 142 8.9E-50 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 SUPERFAMILY SSF53671 2 312 1.7E-93 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 Gene3D G3DSA:3.40.50.1370 143 288 4.6E-49 T 17-03-2017 IPR006130 Aspartate/ornithine carbamoyltransferase GO:0006520|GO:0016597|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 TIGRFAM TIGR00670 asp_carb_tr: aspartate carbamoyltransferase 3 310 2.7E-91 T 17-03-2017 IPR002082 Aspartate carbamoyltransferase GO:0004070|GO:0006207 KEGG: 00240+2.1.3.2|KEGG: 00250+2.1.3.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 Pfam PF02729 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain 3 147 7.4E-40 T 17-03-2017 IPR006132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding GO:0006520|GO:0016743 SHXM_RS12375 96f78de27897b09bc1ad07bb3b5d6f4a 325 Pfam PF00185 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain 163 309 4.4E-23 T 17-03-2017 IPR006131 Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain GO:0006520|GO:0016597|GO:0016743 SHXM_RS12570 73cee7a4830642d6c973280f0821a8de 185 SUPERFAMILY SSF140478 25 139 1.18E-5 T 17-03-2017 IPR023353 LemA-like domain SHXM_RS12570 73cee7a4830642d6c973280f0821a8de 185 Gene3D G3DSA:1.20.1440.20 15 138 8.1E-7 T 17-03-2017 IPR023353 LemA-like domain SHXM_RS12570 73cee7a4830642d6c973280f0821a8de 185 Pfam PF04011 LemA family 7 139 3.6E-5 T 17-03-2017 IPR007156 LemA SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Gene3D G3DSA:3.40.50.620 4 141 2.1E-79 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Gene3D G3DSA:3.40.50.620 181 392 2.1E-79 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Gene3D G3DSA:1.10.730.10 393 558 2.6E-39 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 SUPERFAMILY SSF52374 174 397 2.88E-81 T 17-03-2017 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 SUPERFAMILY SSF52374 4 138 2.88E-81 T 17-03-2017 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 SUPERFAMILY SSF57770 139 172 1.06E-11 T 17-03-2017 IPR029038 Methionyl-tRNA synthetase, Zn-domain KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 SUPERFAMILY SSF47323 398 558 2.06E-33 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 PRINTS PR01041 Methionyl-tRNA synthetase signature 397 408 1.1E-27 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 PRINTS PR01041 Methionyl-tRNA synthetase signature 257 268 1.1E-27 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 PRINTS PR01041 Methionyl-tRNA synthetase signature 303 318 1.1E-27 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 PRINTS PR01041 Methionyl-tRNA synthetase signature 6 19 1.1E-27 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 PRINTS PR01041 Methionyl-tRNA synthetase signature 39 53 1.1E-27 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 PRINTS PR01041 Methionyl-tRNA synthetase signature 87 98 1.1E-27 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Pfam PF09334 tRNA synthetases class I (M) 4 410 1.3E-152 T 17-03-2017 IPR015413 Methionyl/Leucyl tRNA synthetase GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Gene3D G3DSA:2.20.28.20 142 173 1.4E-18 T 17-03-2017 IPR029038 Methionyl-tRNA synthetase, Zn-domain KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Hamap MF_00098 Methionine--tRNA ligase [metG]. 2 569 37.429 T 17-03-2017 IPR023458 Methionine-tRNA ligase, type 1 GO:0004825 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10|Reactome: R-HSA-2408517|Reactome: R-HSA-379716 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 Pfam PF08264 Anticodon-binding domain of tRNA 437 516 3.0E-6 T 17-03-2017 IPR013155 Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding GO:0000166|GO:0006418 SHXM_RS28545 b95ca351e20083f55a7f45fc6c15dba4 581 TIGRFAM TIGR00398 metG: methionine--tRNA ligase 5 540 2.5E-144 T 17-03-2017 IPR014758 Methionyl-tRNA synthetase GO:0000166|GO:0004825|GO:0005524|GO:0005737|GO:0006431 KEGG: 00450+6.1.1.10|KEGG: 00970+6.1.1.10 SHXM_RS35040 334ec679e32b2856f4d9d2209ffd6a78 217 Gene3D G3DSA:3.30.565.10 19 132 6.2E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35040 334ec679e32b2856f4d9d2209ffd6a78 217 Pfam PF13581 Histidine kinase-like ATPase domain 14 128 1.1E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35040 334ec679e32b2856f4d9d2209ffd6a78 217 SUPERFAMILY SSF55874 36 131 1.78E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29990 270303f5af0a3940788c24f487e3cd7c 140 SUPERFAMILY SSF47413 8 69 7.24E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS29990 270303f5af0a3940788c24f487e3cd7c 140 Pfam PF01381 Helix-turn-helix 13 65 3.6E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS29990 270303f5af0a3940788c24f487e3cd7c 140 SMART SM00530 12 67 6.4E-16 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS29990 270303f5af0a3940788c24f487e3cd7c 140 Gene3D G3DSA:1.10.260.40 8 109 5.6E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 Pfam PF00118 TCP-1/cpn60 chaperonin family 22 524 6.6E-94 T 17-03-2017 IPR002423 Chaperonin Cpn60/TCP-1 family GO:0005524 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 SUPERFAMILY SSF54849 136 203 1.33E-24 T 17-03-2017 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 Hamap MF_00600 60 kDa chaperonin [groL]. 1 539 41.438 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 ProSitePatterns PS00296 Chaperonins cpn60 signature. 405 416 - T 17-03-2017 IPR018370 Chaperonin Cpn60, conserved site GO:0005524|GO:0005737|GO:0006457 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 PRINTS PR00298 60kDa chaperonin signature 26 52 3.7E-71 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 PRINTS PR00298 60kDa chaperonin signature 350 375 3.7E-71 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 PRINTS PR00298 60kDa chaperonin signature 268 291 3.7E-71 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 PRINTS PR00298 60kDa chaperonin signature 398 419 3.7E-71 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 PRINTS PR00298 60kDa chaperonin signature 82 109 3.7E-71 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 Gene3D G3DSA:1.10.560.10 371 518 4.7E-39 T 17-03-2017 IPR027413 GroEL-like equatorial domain SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 SUPERFAMILY SSF48592 6 133 5.25E-73 T 17-03-2017 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 SUPERFAMILY SSF48592 406 521 5.25E-73 T 17-03-2017 SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 Gene3D G3DSA:3.50.7.10 195 370 1.5E-89 T 17-03-2017 IPR027409 GroEL-like apical domain SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 Gene3D G3DSA:1.10.560.10 6 194 1.9E-43 T 17-03-2017 IPR027413 GroEL-like equatorial domain SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 SUPERFAMILY SSF52029 184 376 2.39E-79 T 17-03-2017 IPR027409 GroEL-like apical domain SHXM_RS31540 f5a8fe892ac2c8cdab1f1e77da4aff1f 541 TIGRFAM TIGR02348 GroEL: chaperonin GroL 2 526 1.1E-243 T 17-03-2017 IPR001844 Chaperonin Cpn60 GO:0005737|GO:0042026 Reactome: R-HSA-1268020 SHXM_RS16705 1d762449a554f6fb769bc4d042df7341 163 SMART SM00823 Phosphopantetheine attachment site 96 163 1.6E-18 T 17-03-2017 IPR020806 Polyketide synthase, phosphopantetheine-binding domain GO:0031177 Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16705 1d762449a554f6fb769bc4d042df7341 163 SUPERFAMILY SSF47336 92 163 1.96E-18 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS16705 1d762449a554f6fb769bc4d042df7341 163 Pfam PF00550 Phosphopantetheine attachment site 98 163 1.9E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS16705 1d762449a554f6fb769bc4d042df7341 163 SMART SM01294 97 163 0.0021 T 17-03-2017 SHXM_RS16705 1d762449a554f6fb769bc4d042df7341 163 Gene3D G3DSA:1.10.1200.10 92 163 2.6E-19 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 SMART SM00220 20 287 2.8E-63 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 Pfam PF03793 PASTA domain 482 543 2.3E-5 T 17-03-2017 IPR005543 PASTA domain SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 SUPERFAMILY SSF56112 16 375 8.9E-74 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 Pfam PF00069 Protein kinase domain 20 283 2.1E-49 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 Gene3D G3DSA:1.10.510.10 117 297 3.9E-47 T 17-03-2017 SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 26 49 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 Gene3D G3DSA:3.30.200.20 13 103 5.5E-26 T 17-03-2017 SHXM_RS28415 74070d69064c077c1a9187751ad553b1 547 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 147 159 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS42615 3080c8d5f3bbb5ea9d3512cc193f5986 154 SUPERFAMILY SSF46785 2 131 6.49E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42615 3080c8d5f3bbb5ea9d3512cc193f5986 154 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 2 130 3.9E-33 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS42615 3080c8d5f3bbb5ea9d3512cc193f5986 154 Gene3D G3DSA:1.10.10.10 2 131 2.0E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42615 3080c8d5f3bbb5ea9d3512cc193f5986 154 Pfam PF02082 Transcriptional regulator 2 81 7.9E-24 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 SUPERFAMILY SSF46955 1 113 7.33E-24 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 Pfam PF13411 MerR HTH family regulatory protein 1 65 4.8E-17 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 SMART SM00422 1 69 2.7E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 36 56 4.2E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 4.2E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 4.2E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33145 0541f875d85a85b5233f2d9b825da1dc 127 Gene3D G3DSA:1.10.1660.10 1 110 8.9E-26 T 17-03-2017 SHXM_RS13500 9ff75f2a103df997be96cf8faec66be7 286 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 23 258 1.1E-54 T 17-03-2017 IPR018713 Domain of unknown function DUF2236 SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 Gene3D G3DSA:3.90.1150.10 284 418 3.0E-45 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 Gene3D G3DSA:3.40.640.10 37 283 3.5E-105 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 7 417 50.515 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 SUPERFAMILY SSF53383 3 418 8.66E-172 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 Pfam PF00464 Serine hydroxymethyltransferase 9 389 5.2E-163 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 PIRSF PIRSF000412 1 415 3.3E-156 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS35950 27d89f332390c10010d541f89c710bf3 421 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 222 238 - T 17-03-2017 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0004372|GO:0006544|GO:0006563|GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS11980 fc594280b52c172becd34d602b316b82 596 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 146 522 8.4E-38 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS11980 fc594280b52c172becd34d602b316b82 596 SUPERFAMILY SSF53649 142 571 1.16E-28 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS11980 fc594280b52c172becd34d602b316b82 596 Gene3D G3DSA:3.40.720.10 140 458 2.4E-29 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 SUPERFAMILY SSF55874 190 314 8.38E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 SMART SM00387 227 317 5.1E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 Pfam PF00672 HAMP domain 39 109 5.4E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 SMART SM00304 57 112 2.9E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 Gene3D G3DSA:3.30.565.10 225 317 7.2E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 Gene3D G3DSA:3.30.565.10 167 179 7.2E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 231 310 5.1E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39460 176d989b211700effc676cd1834e6c5a 320 Pfam PF07730 Histidine kinase 125 189 1.8E-18 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS11605 87cb26a781d0c28b4a26259e98104391 464 Gene3D G3DSA:1.10.443.10 239 440 2.4E-18 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS11605 87cb26a781d0c28b4a26259e98104391 464 SUPERFAMILY SSF56349 170 436 2.83E-26 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 TIGRFAM TIGR02067 his_9_HisN: histidinol-phosphatase 8 262 1.6E-89 T 17-03-2017 IPR011809 Histidinol-phosphate phosphatase, putative, inositol monophosphatase GO:0004401 KEGG: 00340+3.1.3.15 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 Gene3D G3DSA:3.30.540.10 3 158 2.3E-44 T 17-03-2017 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 ProSitePatterns PS00629 Inositol monophosphatase family signature 1. 81 94 - T 17-03-2017 IPR020583 Inositol monophosphatase, metal-binding site SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 81 97 5.8E-13 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 40 60 5.8E-13 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 PRINTS PR00377 Inositol monophosphatase superfamily signature 62 78 5.8E-13 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 SUPERFAMILY SSF56655 3 263 3.14E-73 T 17-03-2017 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 Pfam PF00459 Inositol monophosphatase family 15 239 7.4E-47 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS34420 bf7cde47658aab8cca4ab0c9bc4a613a 264 Gene3D G3DSA:3.40.190.80 159 263 3.6E-23 T 17-03-2017 SHXM_RS29955 b2ababa372c08402e22f6ba12056c661 329 SUPERFAMILY SSF161098 72 313 4.19E-32 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS29955 b2ababa372c08402e22f6ba12056c661 329 TIGRFAM TIGR02138 phosphate_pstC: phosphate ABC transporter, permease protein PstC 29 321 1.3E-87 T 17-03-2017 IPR011864 Phosphate ABC transporter, permease protein PstC GO:0005315|GO:0006817|GO:0016021 SHXM_RS29955 b2ababa372c08402e22f6ba12056c661 329 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 108 320 5.8E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS29955 b2ababa372c08402e22f6ba12056c661 329 Gene3D G3DSA:1.10.3720.10 40 324 1.6E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49920 7c7a717b4a64e3ed7e69804c46e1b813 192 Pfam PF03459 TOBE domain 136 186 3.3E-7 T 17-03-2017 IPR005116 Transport-associated OB, type 1 SHXM_RS27250 efbadd45d5c01bbb512c8ff4005cf93f 152 Gene3D G3DSA:3.30.530.20 4 133 2.4E-7 T 17-03-2017 IPR023393 START-like domain SHXM_RS27250 efbadd45d5c01bbb512c8ff4005cf93f 152 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 10 125 8.1E-14 T 17-03-2017 IPR005031 Coenzyme Q-binding protein COQ10, START domain SHXM_RS27250 efbadd45d5c01bbb512c8ff4005cf93f 152 SUPERFAMILY SSF55961 1 145 1.22E-22 T 17-03-2017 SHXM_RS30325 0d821a5c5ec680e40943062aea22f309 309 SUPERFAMILY SSF53067 129 306 1.2E-37 T 17-03-2017 SHXM_RS30325 0d821a5c5ec680e40943062aea22f309 309 Gene3D G3DSA:3.30.420.150 125 305 2.7E-48 T 17-03-2017 SHXM_RS30325 0d821a5c5ec680e40943062aea22f309 309 Gene3D G3DSA:3.30.420.40 1 123 1.5E-33 T 17-03-2017 SHXM_RS30325 0d821a5c5ec680e40943062aea22f309 309 Pfam PF02541 Ppx/GppA phosphatase family 28 305 3.3E-72 T 17-03-2017 IPR003695 Ppx/GppA phosphatase KEGG: 00230+3.6.1.40 SHXM_RS30325 0d821a5c5ec680e40943062aea22f309 309 SUPERFAMILY SSF53067 2 125 6.04E-30 T 17-03-2017 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 152 167 2.3E-9 T 17-03-2017 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 2.3E-9 T 17-03-2017 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 286 301 2.3E-9 T 17-03-2017 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 301 317 2.3E-9 T 17-03-2017 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 SUPERFAMILY SSF51905 5 173 5.41E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 SUPERFAMILY SSF51905 273 380 5.41E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 Gene3D G3DSA:3.50.50.60 5 178 4.9E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 Gene3D G3DSA:3.50.50.60 274 344 4.9E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50585 ff856d38528c899fadd014969ce35a2a 403 Pfam PF01494 FAD binding domain 6 321 1.4E-14 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS11970 b309b4b308ea256589cccf315603d5f9 268 Gene3D G3DSA:3.40.50.620 4 218 1.8E-53 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS11970 b309b4b308ea256589cccf315603d5f9 268 SUPERFAMILY SSF52402 5 205 6.02E-56 T 17-03-2017 SHXM_RS11970 b309b4b308ea256589cccf315603d5f9 268 Pfam PF01507 Phosphoadenosine phosphosulfate reductase family 25 222 5.8E-41 T 17-03-2017 IPR002500 Phosphoadenosine phosphosulphate reductase GO:0003824|GO:0008152 Reactome: R-HSA-196843 SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 Gene3D G3DSA:3.40.50.1820 23 306 3.2E-66 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 SUPERFAMILY SSF53474 21 306 1.06E-70 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 Pfam PF00561 alpha/beta hydrolase fold 49 291 2.6E-19 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 PRINTS PR00412 Epoxide hydrolase signature 55 73 1.5E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 PRINTS PR00412 Epoxide hydrolase signature 283 305 1.5E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 PRINTS PR00412 Epoxide hydrolase signature 118 131 1.5E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01290 7e45b8ae7362108da8dbf8fd607227dd 320 PRINTS PR00412 Epoxide hydrolase signature 132 145 1.5E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS07520 a8bb9073169cadd49e0ddcde246f8bf0 403 SUPERFAMILY SSF46689 288 367 6.57E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS07520 a8bb9073169cadd49e0ddcde246f8bf0 403 Pfam PF13556 PucR C-terminal helix-turn-helix domain 332 389 5.6E-16 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS07520 a8bb9073169cadd49e0ddcde246f8bf0 403 Pfam PF05651 Putative sugar diacid recognition 14 146 1.4E-36 T 17-03-2017 IPR008599 Putative sugar diacid recognition SHXM_RS07520 a8bb9073169cadd49e0ddcde246f8bf0 403 Gene3D G3DSA:1.10.10.60 349 368 1.1E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 TIGRFAM TIGR00105 L31: ribosomal protein bL31 1 80 4.3E-20 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 PRINTS PR01249 Ribosomal protein L31 signature 2 19 2.8E-19 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 PRINTS PR01249 Ribosomal protein L31 signature 60 78 2.8E-19 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 PRINTS PR01249 Ribosomal protein L31 signature 45 60 2.8E-19 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 ProSitePatterns PS01143 Ribosomal protein L31 signature. 49 70 - T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 SUPERFAMILY SSF143800 1 79 1.06E-22 T 17-03-2017 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 Hamap MF_00502 50S ribosomal protein L31 type B [rpmE2]. 1 81 26.983 T 17-03-2017 IPR027493 Ribosomal protein L31 type B GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05980 52ca37603a83e55630f34dfba8ade0cc 85 Pfam PF01197 Ribosomal protein L31 1 79 1.9E-30 T 17-03-2017 IPR002150 Ribosomal protein L31 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS01700 7b2e27f9a986c7d3747792c96b799fd4 343 Gene3D G3DSA:3.20.20.30 3 339 2.8E-82 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01700 7b2e27f9a986c7d3747792c96b799fd4 343 TIGRFAM TIGR03858 LLM_2I7G: probable oxidoreductase, LLM family 6 338 6.9E-151 T 17-03-2017 IPR022290 Conserved hypothetical protein CHP03858, luciferase-like monooxygenase, putative SHXM_RS01700 7b2e27f9a986c7d3747792c96b799fd4 343 Pfam PF00296 Luciferase-like monooxygenase 23 305 8.1E-45 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01700 7b2e27f9a986c7d3747792c96b799fd4 343 SUPERFAMILY SSF51679 6 339 1.31E-73 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS43030 a77f2cb9d5fe35209bc2c9568f395791 245 Pfam PF02424 ApbE family 85 217 9.4E-32 T 17-03-2017 IPR024932 Flavin transferase ApbE GO:0017013 SHXM_RS43030 a77f2cb9d5fe35209bc2c9568f395791 245 Pfam PF02424 ApbE family 1 83 1.3E-10 T 17-03-2017 IPR024932 Flavin transferase ApbE GO:0017013 SHXM_RS43030 a77f2cb9d5fe35209bc2c9568f395791 245 SUPERFAMILY SSF143631 1 237 5.89E-59 T 17-03-2017 IPR003374 ApbE-like domain SHXM_RS16425 082e6e51708ebcefa83b8da57b8cd412 352 SUPERFAMILY SSF48576 20 350 1.04E-66 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS16425 082e6e51708ebcefa83b8da57b8cd412 352 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 238 250 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS16425 082e6e51708ebcefa83b8da57b8cd412 352 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 101 115 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS16425 082e6e51708ebcefa83b8da57b8cd412 352 Pfam PF00348 Polyprenyl synthetase 57 284 2.1E-49 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS16425 082e6e51708ebcefa83b8da57b8cd412 352 Gene3D G3DSA:1.10.600.10 16 351 1.6E-72 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13575 0e61e2c1c331b14403b3977555d5f764 137 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 120 1.1E-33 T 17-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 Gene3D G3DSA:3.40.50.1820 22 284 8.4E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 PRINTS PR00111 Alpha/beta hydrolase fold signature 108 121 1.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 PRINTS PR00111 Alpha/beta hydrolase fold signature 229 243 1.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 PRINTS PR00111 Alpha/beta hydrolase fold signature 59 74 1.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 PRINTS PR00412 Epoxide hydrolase signature 108 121 2.0E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 PRINTS PR00412 Epoxide hydrolase signature 40 58 2.0E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 PRINTS PR00412 Epoxide hydrolase signature 260 282 2.0E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 SUPERFAMILY SSF53474 21 284 4.59E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS36020 30bd0157926c1a2b1640cc7c7f42462b 286 Pfam PF12697 Alpha/beta hydrolase family 36 276 1.5E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 73 85 1.3E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 57 73 1.3E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 43 57 1.3E-10 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 ProSitePatterns PS00622 LuxR-type HTH domain signature. 57 84 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 SMART SM00421 40 97 5.7E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 Pfam PF00196 Bacterial regulatory proteins, luxR family 43 94 7.2E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 Gene3D G3DSA:1.10.10.10 38 99 1.5E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13395 9a7a7a75fd29da7036fb31baae9bfc2f 115 SUPERFAMILY SSF46894 33 101 2.69E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS00250 563dd8e39f9df5e0d75d93749b711ed0 271 Gene3D G3DSA:3.40.50.150 5 268 4.0E-90 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00250 563dd8e39f9df5e0d75d93749b711ed0 271 Pfam PF04672 S-adenosyl methyltransferase 9 267 8.6E-82 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS00250 563dd8e39f9df5e0d75d93749b711ed0 271 SUPERFAMILY SSF53335 13 263 5.32E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00250 563dd8e39f9df5e0d75d93749b711ed0 271 PIRSF PIRSF017393 1 269 4.1E-77 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS22085 a45c6e53bf64b26161cd1fff5656e0d0 111 Gene3D G3DSA:3.30.70.120 5 109 1.5E-41 T 17-03-2017 IPR015867 Nitrogen regulatory protein PII/ATP phosphoribosyltransferase, C-terminal SHXM_RS22085 a45c6e53bf64b26161cd1fff5656e0d0 111 SUPERFAMILY SSF54913 6 104 2.39E-32 T 17-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta SHXM_RS22085 a45c6e53bf64b26161cd1fff5656e0d0 111 Pfam PF02641 Uncharacterized ACR, COG1993 8 103 2.7E-36 T 17-03-2017 IPR003793 Domain of unknown function DUF190 SHXM_RS46220 8499ad92465d4dd55a34cff28492d016 299 SUPERFAMILY SSF55347 151 244 1.8E-10 T 17-03-2017 SHXM_RS46220 8499ad92465d4dd55a34cff28492d016 299 Gene3D G3DSA:3.40.50.720 1 128 1.3E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46220 8499ad92465d4dd55a34cff28492d016 299 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 1 112 4.7E-18 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS46220 8499ad92465d4dd55a34cff28492d016 299 SUPERFAMILY SSF51735 1 131 1.49E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS46220 8499ad92465d4dd55a34cff28492d016 299 Gene3D G3DSA:3.30.360.10 151 296 2.3E-15 T 17-03-2017 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 TIGRFAM TIGR00204 dxs: 1-deoxy-D-xylulose-5-phosphate synthase 4 619 4.7E-188 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Gene3D G3DSA:3.40.50.970 330 477 6.9E-29 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Pfam PF13292 1-deoxy-D-xylulose-5-phosphate synthase 3 278 6.1E-106 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 SMART SM00861 314 478 1.3E-50 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Pfam PF02779 Transketolase, pyrimidine binding domain 314 476 7.0E-37 T 17-03-2017 IPR005475 Transketolase-like, pyrimidine-binding domain SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Gene3D G3DSA:3.40.50.970 18 193 4.3E-61 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Gene3D G3DSA:3.40.50.970 238 329 4.3E-61 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 SUPERFAMILY SSF52518 293 476 7.5E-51 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 ProSitePatterns PS00801 Transketolase signature 1. 28 47 - T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Pfam PF02780 Transketolase, C-terminal domain 497 614 3.3E-31 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Gene3D G3DSA:3.40.50.920 500 621 4.0E-32 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 Hamap MF_00315 1-deoxy-D-xylulose-5-phosphate synthase [dxs]. 2 623 41.603 T 17-03-2017 IPR005477 Deoxyxylulose-5-phosphate synthase GO:0008661|GO:0016114 KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 SUPERFAMILY SSF52922 499 621 2.75E-29 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 SUPERFAMILY SSF52518 3 344 9.35E-71 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS38205 a027eac1a7b383cd4e204afc95f00e78 654 ProSitePatterns PS00802 Transketolase signature 2. 420 436 - T 17-03-2017 IPR020826 Transketolase binding site KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS13075 1d734ab3869f88f2db05960a58de1418 207 Gene3D G3DSA:1.10.10.60 6 59 6.5E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13075 1d734ab3869f88f2db05960a58de1418 207 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 62 4.1E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13075 1d734ab3869f88f2db05960a58de1418 207 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 7.7E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13075 1d734ab3869f88f2db05960a58de1418 207 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 7.7E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13075 1d734ab3869f88f2db05960a58de1418 207 SUPERFAMILY SSF46689 5 77 6.48E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13075 1d734ab3869f88f2db05960a58de1418 207 Gene3D G3DSA:1.10.357.10 60 201 7.2E-13 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS49785 a42d4eea739a43b8cda359ccc72c0f51 302 SUPERFAMILY SSF51197 69 252 1.3E-24 T 17-03-2017 SHXM_RS49785 a42d4eea739a43b8cda359ccc72c0f51 302 Pfam PF03171 2OG-Fe(II) oxygenase superfamily 153 247 2.6E-8 T 17-03-2017 IPR005123 Oxoglutarate/iron-dependent dioxygenase GO:0016491|GO:0055114 SHXM_RS49785 a42d4eea739a43b8cda359ccc72c0f51 302 Gene3D G3DSA:2.60.120.330 101 258 1.2E-23 T 17-03-2017 IPR027443 Isopenicillin N synthase-like SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 39 59 2.3E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 4 15 2.3E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 15 28 2.3E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 Pfam PF13411 MerR HTH family regulatory protein 3 70 1.0E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 SUPERFAMILY SSF89082 160 251 1.02E-29 T 17-03-2017 IPR012925 TipAS antibiotic-recognition domain SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 Pfam PF07739 TipAS antibiotic-recognition domain 132 246 7.1E-41 T 17-03-2017 IPR012925 TipAS antibiotic-recognition domain SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 SMART SM00422 3 72 4.2E-30 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 Gene3D G3DSA:1.10.1660.10 2 57 5.6E-25 T 17-03-2017 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 Gene3D G3DSA:1.10.490.50 160 251 9.9E-35 T 17-03-2017 IPR012925 TipAS antibiotic-recognition domain SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 ProSitePatterns PS00552 MerR-type HTH domain signature. 6 28 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 SUPERFAMILY SSF46955 3 103 1.94E-28 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS26490 89ffcac930abded6d5f006d6cdb38871 252 Gene3D G3DSA:1.10.1660.10 58 105 2.7E-9 T 17-03-2017 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 SUPERFAMILY SSF48264 15 407 3.67E-88 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 Gene3D G3DSA:1.10.630.10 10 408 4.3E-116 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00385 P450 superfamily signature 247 264 5.9E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00385 P450 superfamily signature 349 358 5.9E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00385 P450 superfamily signature 358 369 5.9E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00385 P450 superfamily signature 282 293 5.9E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 328 343 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 358 369 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 201 223 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 300 327 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 138 154 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 155 170 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 282 293 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 349 358 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 PRINTS PR00359 B-class P450 signature 88 99 1.2E-53 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 Pfam PF00067 Cytochrome P450 283 391 1.7E-19 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 Pfam PF00067 Cytochrome P450 85 276 1.4E-10 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS27290 f28d8ea389a9c6cc2130140fb7fa1aed 428 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 351 360 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS48160 e9362c5cc2708e48d6d19c185f7814fa 208 Pfam PF00857 Isochorismatase family 16 167 1.2E-20 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS48160 e9362c5cc2708e48d6d19c185f7814fa 208 SUPERFAMILY SSF52499 8 187 3.14E-37 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS48160 e9362c5cc2708e48d6d19c185f7814fa 208 Gene3D G3DSA:3.40.50.850 10 188 2.6E-32 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Pfam PF01266 FAD dependent oxidoreductase 3 370 2.0E-43 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Gene3D G3DSA:3.50.50.60 134 212 3.7E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Gene3D G3DSA:3.50.50.60 2 70 3.7E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Gene3D G3DSA:3.50.50.60 277 288 3.7E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Gene3D G3DSA:3.50.50.60 344 371 3.7E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 TIGRFAM TIGR03364 HpnW_proposed: FAD dependent oxidoreductase TIGR03364 2 366 8.9E-98 T 17-03-2017 IPR017741 FAD-dependent oxidoreductase, HpnW SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Gene3D G3DSA:3.30.9.10 82 133 2.9E-4 T 17-03-2017 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 Gene3D G3DSA:3.30.9.10 213 233 2.9E-4 T 17-03-2017 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 SUPERFAMILY SSF51905 2 213 1.68E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42445 1566946d0023f412c078eca96628bba6 374 SUPERFAMILY SSF51905 332 372 1.68E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 Pfam PF00486 Transcriptional regulatory protein, C terminal 149 224 1.3E-27 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 Pfam PF00072 Response regulator receiver domain 4 113 9.8E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 Gene3D G3DSA:3.40.50.2300 3 121 5.0E-40 T 17-03-2017 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 SUPERFAMILY SSF46894 125 225 1.56E-31 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 SMART SM00862 148 224 7.5E-30 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 Gene3D G3DSA:1.10.10.10 128 225 3.1E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 SMART SM00448 2 112 6.4E-45 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26040 a84179091f08f8209ee1e1b8278651d4 226 SUPERFAMILY SSF52172 3 124 2.85E-41 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS26435 518ed71175ac848f77eb0782ff53b7dd 197 TIGRFAM TIGR01498 folK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 32 163 6.7E-45 T 17-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26435 518ed71175ac848f77eb0782ff53b7dd 197 Gene3D G3DSA:3.30.70.560 31 184 8.5E-56 T 17-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26435 518ed71175ac848f77eb0782ff53b7dd 197 Pfam PF01288 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) 33 163 1.7E-37 T 17-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26435 518ed71175ac848f77eb0782ff53b7dd 197 SUPERFAMILY SSF55083 31 179 1.26E-49 T 17-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26435 518ed71175ac848f77eb0782ff53b7dd 197 ProSitePatterns PS00794 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. 118 129 - T 17-03-2017 IPR000550 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK GO:0003848|GO:0009396 KEGG: 00790+2.7.6.3|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS01730 7c2186fd8443306f4df0bcf42dba286a 187 Gene3D G3DSA:3.10.450.50 15 144 5.3E-16 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS01730 7c2186fd8443306f4df0bcf42dba286a 187 Pfam PF07366 SnoaL-like polyketide cyclase 19 144 5.3E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS01730 7c2186fd8443306f4df0bcf42dba286a 187 SUPERFAMILY SSF54427 13 144 2.7E-23 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS42420 0185e91e329824fa326b38abf2b04913 350 Gene3D G3DSA:3.40.190.10 277 314 5.3E-37 T 17-03-2017 SHXM_RS42420 0185e91e329824fa326b38abf2b04913 350 Gene3D G3DSA:3.40.190.10 7 133 5.3E-37 T 17-03-2017 SHXM_RS42420 0185e91e329824fa326b38abf2b04913 350 SUPERFAMILY SSF53850 30 344 1.04E-53 T 17-03-2017 SHXM_RS42420 0185e91e329824fa326b38abf2b04913 350 Gene3D G3DSA:3.40.190.10 139 276 6.1E-25 T 17-03-2017 SHXM_RS42420 0185e91e329824fa326b38abf2b04913 350 Pfam PF13343 Bacterial extracellular solute-binding protein 86 336 9.0E-25 T 17-03-2017 SHXM_RS46335 77d4d21db8988592e341587864933911 179 TIGRFAM TIGR03126 one_C_fae: formaldehyde-activating enzyme 10 163 2.4E-39 T 17-03-2017 IPR014826 Formaldehyde-activating enzyme GO:0016051|GO:0016840 KEGG: 00030+4.1.2.43|KEGG: 00680+4.2.1.147+4.1.2.43|MetaCyc: PWY-1723|MetaCyc: PWY-1861 SHXM_RS46335 77d4d21db8988592e341587864933911 179 SUPERFAMILY SSF54211 9 162 5.31E-45 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS46335 77d4d21db8988592e341587864933911 179 Pfam PF08714 Formaldehyde-activating enzyme (Fae) 11 163 6.4E-52 T 17-03-2017 IPR014826 Formaldehyde-activating enzyme GO:0016051|GO:0016840 KEGG: 00030+4.1.2.43|KEGG: 00680+4.2.1.147+4.1.2.43|MetaCyc: PWY-1723|MetaCyc: PWY-1861 SHXM_RS46335 77d4d21db8988592e341587864933911 179 Gene3D G3DSA:3.30.230.60 9 163 8.9E-51 T 17-03-2017 IPR014826 Formaldehyde-activating enzyme GO:0016051|GO:0016840 KEGG: 00030+4.1.2.43|KEGG: 00680+4.2.1.147+4.1.2.43|MetaCyc: PWY-1723|MetaCyc: PWY-1861 SHXM_RS13650 d955c7ca9aaa31e5987ff02f08a83800 321 SUPERFAMILY SSF51679 1 319 6.77E-67 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13650 d955c7ca9aaa31e5987ff02f08a83800 321 TIGRFAM TIGR03557 F420_G6P_family: F420-dependent oxidoreductase, G6PDH family 5 320 7.2E-155 T 17-03-2017 IPR019945 F420-dependent glucose-6-phosphate dehydrogenase-related SHXM_RS13650 d955c7ca9aaa31e5987ff02f08a83800 321 Gene3D G3DSA:3.20.20.30 2 319 4.3E-71 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13650 d955c7ca9aaa31e5987ff02f08a83800 321 Pfam PF00296 Luciferase-like monooxygenase 10 291 7.6E-53 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 ProSitePatterns PS01081 TetR-type HTH domain signature. 34 65 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 SUPERFAMILY SSF46689 10 88 1.9E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 65 1.1E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 43 66 2.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 2.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 Gene3D G3DSA:1.10.10.60 11 63 1.7E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42885 9deb62cd46cdcf09714e03385cb5be98 216 Gene3D G3DSA:1.10.357.10 64 209 1.2E-15 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS05985 b5e4fb1252688f2db6accff3bb637339 54 TIGRFAM TIGR01023 rpmG_bact: ribosomal protein bL33 1 54 1.3E-21 T 17-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05985 b5e4fb1252688f2db6accff3bb637339 54 Hamap MF_00294 50S ribosomal protein L33 [rpmG]. 2 54 13.995 T 17-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05985 b5e4fb1252688f2db6accff3bb637339 54 Pfam PF00471 Ribosomal protein L33 9 54 2.0E-15 T 17-03-2017 IPR001705 Ribosomal protein L33 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS05985 b5e4fb1252688f2db6accff3bb637339 54 ProSitePatterns PS00582 Ribosomal protein L33 signature. 22 41 - T 17-03-2017 IPR018264 Ribosomal protein L33, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05985 b5e4fb1252688f2db6accff3bb637339 54 SUPERFAMILY SSF57829 4 54 1.46E-16 T 17-03-2017 IPR011332 Zinc-binding ribosomal protein GO:0006412 SHXM_RS27395 d5bad1b469fa4d02e4ed0ef96d58d11c 260 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 82 4.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27395 d5bad1b469fa4d02e4ed0ef96d58d11c 260 SUPERFAMILY SSF46689 37 92 6.8E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS27395 d5bad1b469fa4d02e4ed0ef96d58d11c 260 SUPERFAMILY SSF48498 114 259 8.56E-26 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS27395 d5bad1b469fa4d02e4ed0ef96d58d11c 260 Gene3D G3DSA:1.10.357.10 24 260 6.5E-59 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS27395 d5bad1b469fa4d02e4ed0ef96d58d11c 260 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 109 257 4.4E-19 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 Pfam PF12804 MobA-like NTP transferase domain 75 224 5.7E-20 T 17-03-2017 IPR025877 MobA-like NTP transferase SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 Gene3D G3DSA:2.160.10.10 409 554 3.7E-30 T 17-03-2017 SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 SUPERFAMILY SSF51161 336 426 1.06E-8 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 Gene3D G3DSA:3.90.550.10 69 328 4.6E-44 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 Gene3D G3DSA:2.160.10.10 329 408 8.1E-7 T 17-03-2017 SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 Hamap MF_01631 Bifunctional protein GlmU [glmU]. 72 570 29.922 T 17-03-2017 IPR005882 Bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase GO:0000287|GO:0000902|GO:0003977|GO:0005737|GO:0009103|GO:0009252|GO:0019134 KEGG: 00520+2.3.1.157+2.7.7.23|KEGG: 00561+2.3.1.15|KEGG: 00564+2.3.1.15|MetaCyc: PWY-5514|MetaCyc: PWY-5667|MetaCyc: PWY-6453|MetaCyc: PWY-7411|MetaCyc: PWY-7587 SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 SUPERFAMILY SSF53448 73 335 1.95E-37 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS37895 ec46b1da0c8ef79f14f5435c304d8046 626 SUPERFAMILY SSF51161 403 553 2.77E-29 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS02645 5961f06d1c3a84cd006510c6ed551259 246 Gene3D G3DSA:3.40.50.150 3 146 9.8E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02645 5961f06d1c3a84cd006510c6ed551259 246 Gene3D G3DSA:3.40.50.150 178 225 9.8E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02645 5961f06d1c3a84cd006510c6ed551259 246 SUPERFAMILY SSF53335 6 240 3.19E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02645 5961f06d1c3a84cd006510c6ed551259 246 Pfam PF13649 Methyltransferase domain 45 137 1.2E-12 T 17-03-2017 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 SUPERFAMILY SSF54373 522 610 4.38E-19 T 17-03-2017 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:1.10.405.10 204 317 7.6E-21 T 17-03-2017 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:3.50.50.60 40 86 2.6E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:3.50.50.60 630 665 4.2E-16 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:3.50.50.60 319 429 4.2E-16 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 SUPERFAMILY SSF51905 55 444 1.27E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 SUPERFAMILY SSF51905 602 664 1.27E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Pfam PF01593 Flavin containing amine oxidoreductase 66 447 6.9E-28 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Pfam PF01593 Flavin containing amine oxidoreductase 528 662 3.3E-18 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:3.90.660.10 87 168 8.6E-57 T 17-03-2017 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:3.90.660.10 524 605 8.6E-57 T 17-03-2017 SHXM_RS42070 c32ffdc92866dc97bb59167a42eea62b 679 Gene3D G3DSA:3.90.660.10 433 452 8.6E-57 T 17-03-2017 SHXM_RS03850 f157383897958ea362e03cd9cab711fe 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 60 4.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03850 f157383897958ea362e03cd9cab711fe 196 Gene3D G3DSA:1.10.357.10 8 189 4.4E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03850 f157383897958ea362e03cd9cab711fe 196 SUPERFAMILY SSF46689 5 75 3.29E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03850 f157383897958ea362e03cd9cab711fe 196 SUPERFAMILY SSF48498 86 191 4.17E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS03850 f157383897958ea362e03cd9cab711fe 196 Pfam PF13305 WHG domain 89 166 3.4E-10 T 17-03-2017 IPR025996 WHG domain SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 312 335 790.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 419 441 120.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 610 637 2600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 442 463 27.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 564 586 25.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 639 666 330.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 383 405 9500.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 541 563 1600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 516 540 790.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 486 510 0.42 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SMART SM00710 587 609 6.5 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 Pfam PF13229 Right handed beta helix region 535 692 1.7E-11 T 17-03-2017 SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SUPERFAMILY SSF51126 476 694 1.91E-16 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 SUPERFAMILY SSF51126 198 542 8.08E-38 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 Pfam PF12708 Pectate lyase superfamily protein 198 459 2.9E-13 T 17-03-2017 IPR024535 Pectate lyase superfamily protein SHXM_RS44665 2fb7cd1987558989b9220cfab3ae48c2 884 Gene3D G3DSA:2.160.20.10 198 595 1.5E-39 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS03505 42a9778ed306307cd5ba43c406ff0b49 136 ProSitePatterns PS01332 Rrf2-type HTH domain signature. 48 66 - T 17-03-2017 IPR030489 Transcription regulator Rrf2-type, conserved site SHXM_RS03505 42a9778ed306307cd5ba43c406ff0b49 136 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 1 131 1.9E-31 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS03505 42a9778ed306307cd5ba43c406ff0b49 136 Gene3D G3DSA:1.10.10.10 1 132 4.6E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03505 42a9778ed306307cd5ba43c406ff0b49 136 SUPERFAMILY SSF46785 3 132 6.25E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03505 42a9778ed306307cd5ba43c406ff0b49 136 Pfam PF02082 Transcriptional regulator 1 82 5.2E-27 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS23045 6307f2dc4f4623c592446c0236b04b87 265 SUPERFAMILY SSF52833 25 221 7.27E-22 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS23045 6307f2dc4f4623c592446c0236b04b87 265 Gene3D G3DSA:3.40.30.10 23 218 1.3E-29 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS23045 6307f2dc4f4623c592446c0236b04b87 265 Pfam PF01323 DSBA-like thioredoxin domain 25 218 1.5E-13 T 17-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 SHXM_RS08715 c06eb9b83b035a35ef7e31e71dec0400 518 SUPERFAMILY SSF55874 222 332 5.83E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08715 c06eb9b83b035a35ef7e31e71dec0400 518 Pfam PF07730 Histidine kinase 137 201 2.4E-11 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 SMART SM00382 40 228 4.7E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 SMART SM00382 287 481 0.0022 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 ProSitePatterns PS00211 ABC transporters family signature. 405 419 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 Pfam PF00005 ABC transporter 279 432 1.4E-19 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 Pfam PF00005 ABC transporter 31 180 2.1E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 Gene3D G3DSA:3.40.50.300 14 235 3.8E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 SUPERFAMILY SSF52540 15 235 7.66E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 SUPERFAMILY SSF52540 277 494 1.21E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22330 e58e7f0508318ebece319d8e0d56f388 522 Gene3D G3DSA:3.40.50.300 260 495 3.7E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34765 b689f9e95a26f246015dceb8cc3619dd 317 Gene3D G3DSA:3.40.190.10 61 160 4.3E-32 T 17-03-2017 SHXM_RS34765 b689f9e95a26f246015dceb8cc3619dd 317 Gene3D G3DSA:3.40.190.10 264 304 4.3E-32 T 17-03-2017 SHXM_RS34765 b689f9e95a26f246015dceb8cc3619dd 317 Gene3D G3DSA:3.40.190.10 165 262 2.3E-18 T 17-03-2017 SHXM_RS34765 b689f9e95a26f246015dceb8cc3619dd 317 SUPERFAMILY SSF53850 21 303 1.3E-51 T 17-03-2017 SHXM_RS34765 b689f9e95a26f246015dceb8cc3619dd 317 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 65 302 9.4E-58 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS34765 b689f9e95a26f246015dceb8cc3619dd 317 SMART SM00062 64 305 4.8E-46 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS20000 0f05e3a33f1514e0d563b3dfee9e7dd5 578 SUPERFAMILY SSF56300 98 223 2.11E-10 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS20000 0f05e3a33f1514e0d563b3dfee9e7dd5 578 SUPERFAMILY SSF56300 272 386 2.11E-10 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS20000 0f05e3a33f1514e0d563b3dfee9e7dd5 578 SUPERFAMILY SSF56300 419 464 2.11E-10 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS20000 0f05e3a33f1514e0d563b3dfee9e7dd5 578 Gene3D G3DSA:3.60.21.10 276 341 7.3E-7 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS20000 0f05e3a33f1514e0d563b3dfee9e7dd5 578 Gene3D G3DSA:3.60.21.10 126 227 7.3E-7 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS20000 0f05e3a33f1514e0d563b3dfee9e7dd5 578 Pfam PF09423 PhoD-like phosphatase 137 466 1.6E-11 T 17-03-2017 IPR018946 Alkaline phosphatase D-related SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 Gene3D G3DSA:2.30.40.10 341 365 3.1E-6 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 Pfam PF01979 Amidohydrolase family 59 384 2.2E-39 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 SUPERFAMILY SSF51556 63 354 1.02E-63 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 Gene3D G3DSA:2.30.40.10 3 64 3.1E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 Gene3D G3DSA:2.30.40.10 366 392 3.1E-19 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 SUPERFAMILY SSF51338 338 391 3.89E-12 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 Gene3D G3DSA:3.20.20.140 65 340 2.2E-66 T 17-03-2017 SHXM_RS49440 8e3e728b998d52b1c683ff3c9d8c4a16 426 SUPERFAMILY SSF51338 7 72 6.91E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS36030 1b4888017358e9062fb1bef9a92c9085 451 Gene3D G3DSA:2.130.10.10 226 396 3.4E-4 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS36030 1b4888017358e9062fb1bef9a92c9085 451 SUPERFAMILY SSF50998 76 375 7.69E-6 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS36030 1b4888017358e9062fb1bef9a92c9085 451 Pfam PF13360 PQQ-like domain 67 185 3.2E-5 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS34015 acd477c1d3f225d4bf64d22a248dccc9 395 SUPERFAMILY SSF55874 290 382 2.75E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34015 acd477c1d3f225d4bf64d22a248dccc9 395 Pfam PF13581 Histidine kinase-like ATPase domain 282 362 4.1E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34015 acd477c1d3f225d4bf64d22a248dccc9 395 Pfam PF07730 Histidine kinase 194 260 7.7E-19 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS34015 acd477c1d3f225d4bf64d22a248dccc9 395 Gene3D G3DSA:3.30.565.10 277 341 7.1E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS04390 7693cc754fbabd92bc9148130e026973 609 SUPERFAMILY SSF50370 455 590 2.03E-19 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS04390 7693cc754fbabd92bc9148130e026973 609 SMART SM00458 462 592 3.1E-10 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS04390 7693cc754fbabd92bc9148130e026973 609 Gene3D G3DSA:2.80.10.50 463 591 1.3E-15 T 17-03-2017 SHXM_RS04390 7693cc754fbabd92bc9148130e026973 609 Pfam PF00652 Ricin-type beta-trefoil lectin domain 464 589 8.6E-16 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS07785 118de1a7debf99c703f1eab76cbf6088 456 SUPERFAMILY SSF51905 298 360 3.42E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07785 118de1a7debf99c703f1eab76cbf6088 456 SUPERFAMILY SSF51905 7 201 3.42E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07785 118de1a7debf99c703f1eab76cbf6088 456 Gene3D G3DSA:3.50.50.60 6 67 2.2E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07785 118de1a7debf99c703f1eab76cbf6088 456 Gene3D G3DSA:3.50.50.60 309 346 2.2E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07785 118de1a7debf99c703f1eab76cbf6088 456 Gene3D G3DSA:3.50.50.60 105 197 2.2E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS00690 cfbe4861547139dc054f036b3b4185e7 354 Pfam PF13358 DDE superfamily endonuclease 156 300 2.5E-14 T 17-03-2017 SHXM_RS00690 cfbe4861547139dc054f036b3b4185e7 354 Pfam PF13565 Homeodomain-like domain 28 109 3.8E-19 T 17-03-2017 SHXM_RS00690 cfbe4861547139dc054f036b3b4185e7 354 SUPERFAMILY SSF46689 1 110 1.7E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00690 cfbe4861547139dc054f036b3b4185e7 354 Gene3D G3DSA:1.10.10.10 4 35 7.8E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43335 9ae85bf98ddc54b02d9c6284be29d3c4 410 Gene3D G3DSA:3.90.550.10 49 273 6.6E-23 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS43335 9ae85bf98ddc54b02d9c6284be29d3c4 410 SUPERFAMILY SSF53448 43 274 3.28E-37 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS43335 9ae85bf98ddc54b02d9c6284be29d3c4 410 TIGRFAM TIGR03469 HpnB: hopene-associated glycosyltransferase HpnB 5 404 1.4E-144 T 17-03-2017 IPR017832 Glycosyl transferase, family 2, hopene-associated, HpnB SHXM_RS43335 9ae85bf98ddc54b02d9c6284be29d3c4 410 Pfam PF13641 Glycosyltransferase like family 2 49 272 5.9E-21 T 17-03-2017 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 Pfam PF01593 Flavin containing amine oxidoreductase 19 461 3.3E-38 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 PRINTS PR00757 Flavin-containing amine oxidase signature 172 193 1.0E-7 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 PRINTS PR00757 Flavin-containing amine oxidase signature 443 460 1.0E-7 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 PRINTS PR00757 Flavin-containing amine oxidase signature 11 30 1.0E-7 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 Gene3D G3DSA:3.50.50.60 227 303 1.1E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 Gene3D G3DSA:3.50.50.60 12 68 1.1E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 Gene3D G3DSA:3.50.50.60 407 468 1.1E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 SUPERFAMILY SSF51905 9 328 7.77E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 SUPERFAMILY SSF51905 422 465 7.77E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13335 a82b9b681ca5bebcf8c4e6313f7aaede 485 TIGRFAM TIGR03467 HpnE: squalene-associated FAD-dependent desaturase 13 462 2.8E-128 T 17-03-2017 IPR017830 Squalene-associated FAD-dependent desaturase SHXM_RS18820 f91c814fc20fccbeafccd17e3c3cec67 380 Pfam PF13439 Glycosyltransferase Family 4 16 178 5.1E-10 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS18820 f91c814fc20fccbeafccd17e3c3cec67 380 Gene3D G3DSA:3.40.50.2000 167 361 5.6E-37 T 17-03-2017 SHXM_RS18820 f91c814fc20fccbeafccd17e3c3cec67 380 Pfam PF00534 Glycosyl transferases group 1 189 362 1.1E-43 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS18820 f91c814fc20fccbeafccd17e3c3cec67 380 SUPERFAMILY SSF53756 5 379 1.18E-76 T 17-03-2017 SHXM_RS42090 aa95dfb6a43e7c374562cdb084c1abbb 336 Pfam PF00248 Aldo/keto reductase family 10 323 8.1E-50 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS42090 aa95dfb6a43e7c374562cdb084c1abbb 336 SUPERFAMILY SSF51430 9 324 3.27E-62 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS42090 aa95dfb6a43e7c374562cdb084c1abbb 336 Gene3D G3DSA:3.20.20.100 10 324 2.8E-56 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS46655 d29ca553b6876566732b0db6a0d35b6c 374 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA) 67 146 3.1E-8 T 17-03-2017 SHXM_RS46655 d29ca553b6876566732b0db6a0d35b6c 374 SUPERFAMILY SSF53335 44 178 8.67E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS46655 d29ca553b6876566732b0db6a0d35b6c 374 Gene3D G3DSA:3.40.50.150 45 174 7.4E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS47070 05415c78dc6b2619a2dbbe14dfb13b4c 476 Pfam PF00171 Aldehyde dehydrogenase family 21 472 4.4E-157 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS47070 05415c78dc6b2619a2dbbe14dfb13b4c 476 SUPERFAMILY SSF53720 4 473 3.27E-154 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS47070 05415c78dc6b2619a2dbbe14dfb13b4c 476 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 274 285 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS47070 05415c78dc6b2619a2dbbe14dfb13b4c 476 Gene3D G3DSA:3.40.309.10 259 449 1.4E-58 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS47070 05415c78dc6b2619a2dbbe14dfb13b4c 476 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 246 253 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS47070 05415c78dc6b2619a2dbbe14dfb13b4c 476 Gene3D G3DSA:3.40.605.10 6 258 1.4E-88 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS06715 ff9a227d4a551daa58d2e91ba7d866a8 390 SUPERFAMILY SSF53067 143 327 2.72E-13 T 17-03-2017 SHXM_RS06715 ff9a227d4a551daa58d2e91ba7d866a8 390 SUPERFAMILY SSF53067 70 110 2.72E-13 T 17-03-2017 SHXM_RS06715 ff9a227d4a551daa58d2e91ba7d866a8 390 SUPERFAMILY SSF53067 1 35 2.72E-13 T 17-03-2017 SHXM_RS06715 ff9a227d4a551daa58d2e91ba7d866a8 390 Pfam PF03702 Uncharacterised protein family (UPF0075) 1 367 5.8E-115 T 17-03-2017 IPR005338 Anhydro-N-acetylmuramic acid kinase GO:0005524|GO:0006040|GO:0009254|GO:0016773 KEGG: 00040+2.7.1.17 SHXM_RS06715 ff9a227d4a551daa58d2e91ba7d866a8 390 Gene3D G3DSA:3.30.420.40 1 196 1.1E-57 T 17-03-2017 SHXM_RS06715 ff9a227d4a551daa58d2e91ba7d866a8 390 Hamap MF_01270 Anhydro-N-acetylmuramic acid kinase [anmK]. 1 368 34.74 T 17-03-2017 IPR005338 Anhydro-N-acetylmuramic acid kinase GO:0005524|GO:0006040|GO:0009254|GO:0016773 KEGG: 00040+2.7.1.17 SHXM_RS12810 f115fb35a03b1a8c911254e7ade4090d 273 SUPERFAMILY SSF53850 36 272 6.46E-82 T 17-03-2017 SHXM_RS12810 f115fb35a03b1a8c911254e7ade4090d 273 Gene3D G3DSA:3.40.190.10 35 165 3.6E-49 T 17-03-2017 SHXM_RS12810 f115fb35a03b1a8c911254e7ade4090d 273 Pfam PF03180 NLPA lipoprotein 36 271 5.7E-92 T 17-03-2017 IPR004872 Lipoprotein NlpA family SHXM_RS12810 f115fb35a03b1a8c911254e7ade4090d 273 PIRSF PIRSF002854 2 273 4.2E-108 T 17-03-2017 IPR004872 Lipoprotein NlpA family SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 PRINTS PR00723 Subtilisin serine protease family (S8) signature 229 248 1.6E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 PRINTS PR00723 Subtilisin serine protease family (S8) signature 266 279 1.6E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 PRINTS PR00723 Subtilisin serine protease family (S8) signature 444 460 1.6E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 ProSitePatterns PS00137 Serine proteases, subtilase family, histidine active site. 270 280 - T 17-03-2017 IPR022398 Peptidase S8, subtilisin, His-active site SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 SUPERFAMILY SSF52743 211 502 7.2E-85 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 234 245 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 Pfam PF00082 Subtilase family 229 493 2.4E-63 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 445 455 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 Gene3D G3DSA:3.40.50.200 196 502 3.3E-89 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS26115 86e69eca1074d43a6f978c5c07aa437f 1113 PIRSF PIRSF037854 1 1113 0.0 T 17-03-2017 IPR017297 Peptidase S8A, DPH-A SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 86 2.4E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 Gene3D G3DSA:3.90.180.10 3 147 2.1E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 SUPERFAMILY SSF50129 3 149 1.73E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 140 161 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 SMART SM00829 11 321 3.6E-28 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 Pfam PF00107 Zinc-binding dehydrogenase 151 255 3.5E-26 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 Gene3D G3DSA:3.40.50.720 148 252 3.7E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48245 a35490247a2d1963dd28d77a410d1453 323 SUPERFAMILY SSF51735 112 268 4.55E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 SMART SM00866 89 228 3.2E-6 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 SUPERFAMILY SSF46785 6 74 2.34E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 Gene3D G3DSA:3.40.1410.10 65 231 1.4E-20 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 44 60 3.6E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 30 44 3.6E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 SUPERFAMILY SSF64288 58 231 1.37E-20 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 Gene3D G3DSA:1.10.10.10 6 64 4.7E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 Pfam PF00392 Bacterial regulatory proteins, gntR family 9 70 2.8E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 SMART SM00345 11 70 3.2E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS45615 ebaa9fe7e746a4955f115b1c5586b439 238 Pfam PF07702 UTRA domain 89 228 4.2E-18 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS19820 cc91bbbca9e1a36a249cf7b580301793 350 SMART SM00849 28 260 8.9E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS19820 cc91bbbca9e1a36a249cf7b580301793 350 SUPERFAMILY SSF56281 7 348 1.83E-55 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS19820 cc91bbbca9e1a36a249cf7b580301793 350 Pfam PF00753 Metallo-beta-lactamase superfamily 28 260 1.2E-17 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS19820 cc91bbbca9e1a36a249cf7b580301793 350 Gene3D G3DSA:3.60.15.10 5 303 2.4E-49 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS23365 0ceca41b711593f295a2f5a6a3471875 155 Pfam PF00578 AhpC/TSA family 8 134 1.1E-33 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS23365 0ceca41b711593f295a2f5a6a3471875 155 SUPERFAMILY SSF52833 4 153 3.29E-45 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS23365 0ceca41b711593f295a2f5a6a3471875 155 Gene3D G3DSA:3.40.30.10 2 153 5.5E-48 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS49675 bf470da6d14041da37b0aab6474c66d6 209 SUPERFAMILY SSF69118 33 190 8.64E-17 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS49675 bf470da6d14041da37b0aab6474c66d6 209 Gene3D G3DSA:1.20.1290.10 58 191 5.8E-12 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 Pfam PF00196 Bacterial regulatory proteins, luxR family 155 209 1.6E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 SMART SM00448 2 116 4.6E-33 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 Gene3D G3DSA:1.10.10.10 125 211 1.7E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 SUPERFAMILY SSF52172 1 133 1.41E-35 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 ProSitePatterns PS00622 LuxR-type HTH domain signature. 170 197 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 SUPERFAMILY SSF46894 142 212 1.9E-19 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 SMART SM00421 153 210 8.2E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 156 170 1.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 170 186 1.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 186 198 1.4E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 Pfam PF00072 Response regulator receiver domain 4 117 8.2E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS47035 e7ea0077eadc913182d9c87a2c1d638d 217 Gene3D G3DSA:3.40.50.2300 1 124 1.3E-37 T 17-03-2017 SHXM_RS45595 5a1e430c96281b0f731f92e9354ace5a 320 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 3 291 2.9E-46 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS45595 5a1e430c96281b0f731f92e9354ace5a 320 PIRSF PIRSF006278 1 309 1.3E-75 T 17-03-2017 IPR027278 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase SHXM_RS45595 5a1e430c96281b0f731f92e9354ace5a 320 Gene3D G3DSA:3.40.50.1100 97 305 6.3E-50 T 17-03-2017 SHXM_RS45595 5a1e430c96281b0f731f92e9354ace5a 320 SUPERFAMILY SSF53686 3 301 1.44E-66 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 Gene3D G3DSA:1.10.357.10 23 248 1.3E-60 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 SUPERFAMILY SSF48498 98 246 1.67E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 95 244 2.2E-22 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 50 7.6E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 58 81 7.6E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 Pfam PF00440 Bacterial regulatory proteins, tetR family 37 80 1.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30020 2a96a199ac19afe8e781ab95217cb067 249 SUPERFAMILY SSF46689 27 86 6.98E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35760 808fdc13ed3d66e4ef00050abaadd40a 282 SUPERFAMILY SSF47413 13 71 3.66E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35760 808fdc13ed3d66e4ef00050abaadd40a 282 SMART SM00530 19 74 3.4E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS35760 808fdc13ed3d66e4ef00050abaadd40a 282 Gene3D G3DSA:1.10.260.40 6 72 1.4E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35760 808fdc13ed3d66e4ef00050abaadd40a 282 Pfam PF13560 Helix-turn-helix domain 15 72 1.3E-12 T 17-03-2017 SHXM_RS34465 e788634ecf55572f94c02b5252e6cf4f 105 TIGRFAM TIGR03988 antisig_RsrA: mycothiol system anti-sigma-R factor 10 84 4.0E-30 T 17-03-2017 IPR024020 Anti sigma-R factor, mycothiol system,RsrA SHXM_RS34465 e788634ecf55572f94c02b5252e6cf4f 105 Pfam PF13490 Putative zinc-finger 11 44 1.5E-8 T 17-03-2017 IPR027383 Putative zinc-finger SHXM_RS34465 e788634ecf55572f94c02b5252e6cf4f 105 TIGRFAM TIGR02949 anti_SigH_actin: anti-sigma factor, TIGR02949 family 4 85 1.5E-35 T 17-03-2017 IPR014295 Anti-sigma factor SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 34 45 1.7E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 24 34 1.7E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 13 24 1.7E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 Gene3D G3DSA:3.40.190.10 85 173 5.7E-19 T 17-03-2017 SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 1 56 2.0E-14 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 Pfam PF03466 LysR substrate binding domain 83 287 4.7E-43 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 SUPERFAMILY SSF46785 1 105 2.86E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 Gene3D G3DSA:1.10.10.10 1 78 5.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 SUPERFAMILY SSF53850 85 293 1.11E-42 T 17-03-2017 SHXM_RS48635 2c5fbda1b3717335fd83f7495f04f77d 306 Gene3D G3DSA:3.40.190.10 174 246 2.6E-19 T 17-03-2017 SHXM_RS42640 12cc76f5eb7883151bd3391eb13c4952 407 Pfam PF04235 Protein of unknown function (DUF418) 234 405 6.0E-30 T 17-03-2017 IPR007349 Domain of unknown function DUF418 SHXM_RS22135 60ccb7e269a417e3100ea1728ea9e53c 312 SUPERFAMILY SSF52151 201 298 2.62E-27 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22135 60ccb7e269a417e3100ea1728ea9e53c 312 SUPERFAMILY SSF52151 8 130 2.62E-27 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS22135 60ccb7e269a417e3100ea1728ea9e53c 312 Gene3D G3DSA:3.40.366.10 3 124 2.6E-22 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS22135 60ccb7e269a417e3100ea1728ea9e53c 312 Gene3D G3DSA:3.40.366.10 200 290 2.6E-22 T 17-03-2017 IPR001227 Acyl transferase domain GO:0008152|GO:0016740 SHXM_RS30425 611cc49aebff9f097a180cd598d425a1 347 SUPERFAMILY SSF51735 2 317 5.26E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30425 611cc49aebff9f097a180cd598d425a1 347 Gene3D G3DSA:3.40.50.720 4 184 2.2E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30425 611cc49aebff9f097a180cd598d425a1 347 Pfam PF01370 NAD dependent epimerase/dehydratase family 5 184 6.6E-17 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS32415 b65220df02e056921ad1bd363921bdd1 501 Pfam PF02080 TrkA-C domain 418 473 1.2E-9 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS32415 b65220df02e056921ad1bd363921bdd1 501 Pfam PF00999 Sodium/hydrogen exchanger family 21 389 2.2E-46 T 17-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SHXM_RS32415 b65220df02e056921ad1bd363921bdd1 501 Gene3D G3DSA:3.30.70.1450 415 473 6.1E-8 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS32415 b65220df02e056921ad1bd363921bdd1 501 SUPERFAMILY SSF116726 413 481 4.58E-11 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS09850 a495ae04ab123328d8a4f8c7463f3817 274 Pfam PF13359 DDE superfamily endonuclease 108 266 2.4E-29 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS09850 a495ae04ab123328d8a4f8c7463f3817 274 Gene3D G3DSA:1.10.10.60 55 78 8.0E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42430 01f8292965cf8b9493ca30b3e9996df6 288 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 90 285 8.9E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42430 01f8292965cf8b9493ca30b3e9996df6 288 TIGRFAM TIGR03226 PhnU: 2-aminoethylphosphonate ABC transporter, permease protein 8 287 1.4E-96 T 17-03-2017 IPR017636 2-aminoethylphosphonate ABC transporter system, permease protein phnU GO:0016020|GO:0033223 SHXM_RS42430 01f8292965cf8b9493ca30b3e9996df6 288 Gene3D G3DSA:1.10.3720.10 23 286 2.2E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42430 01f8292965cf8b9493ca30b3e9996df6 288 SUPERFAMILY SSF161098 19 282 1.96E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19715 20015384183b0f01a853c46359045129 286 SUPERFAMILY SSF102705 4 269 3.01E-80 T 17-03-2017 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SHXM_RS19715 20015384183b0f01a853c46359045129 286 Gene3D G3DSA:3.40.1390.30 4 114 2.7E-42 T 17-03-2017 SHXM_RS19715 20015384183b0f01a853c46359045129 286 Gene3D G3DSA:3.40.1390.30 115 227 3.6E-32 T 17-03-2017 SHXM_RS19715 20015384183b0f01a853c46359045129 286 TIGRFAM TIGR00486 YbgI_SA1388: dinuclear metal center protein, YbgI/SA1388 family 5 236 7.8E-48 T 17-03-2017 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SHXM_RS19715 20015384183b0f01a853c46359045129 286 Pfam PF01784 NIF3 (NGG1p interacting factor 3) 6 247 2.8E-71 T 17-03-2017 IPR002678 GTP cyclohydrolase 1 type 2/Nif3 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 TIGRFAM TIGR00112 proC: pyrroline-5-carboxylate reductase 5 264 2.6E-78 T 17-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 PIRSF PIRSF000193 2 267 1.5E-75 T 17-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 ProSitePatterns PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 220 242 - T 17-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 Hamap MF_01925 Pyrroline-5-carboxylate reductase [proC]. 3 264 26.356 T 17-03-2017 IPR000304 Pyrroline-5-carboxylate reductase GO:0004735|GO:0006561|GO:0055114 KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 4 97 3.4E-21 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 Gene3D G3DSA:1.10.3730.10 159 264 1.1E-40 T 17-03-2017 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 Pfam PF14748 Pyrroline-5-carboxylate reductase dimerisation 160 264 7.2E-38 T 17-03-2017 IPR029036 Pyrroline-5-carboxylate reductase, dimerisation domain KEGG: 00330+1.5.1.2|MetaCyc: PWY-3341|MetaCyc: PWY-4981|MetaCyc: PWY-6344|Reactome: R-HSA-70614 SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 Gene3D G3DSA:3.40.50.720 2 157 7.7E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 SUPERFAMILY SSF51735 4 158 4.73E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30370 a81f6cb740e8a451b887fc91004bd48f 269 SUPERFAMILY SSF48179 159 265 4.93E-35 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS03475 563d590bdf33adced75ddb336e89622e 233 Pfam PF02734 DAK2 domain 40 220 6.0E-40 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS03475 563d590bdf33adced75ddb336e89622e 233 SMART SM01120 39 222 2.0E-44 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS03475 563d590bdf33adced75ddb336e89622e 233 SUPERFAMILY SSF101473 10 219 1.7E-42 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS24600 8c0b73c088c846c8f7f4e12367e2b62d 457 Gene3D G3DSA:3.40.640.10 55 294 2.2E-75 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS24600 8c0b73c088c846c8f7f4e12367e2b62d 457 Pfam PF01212 Beta-eliminating lyase 42 418 1.0E-74 T 17-03-2017 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 Reactome: R-HSA-6783984 SHXM_RS24600 8c0b73c088c846c8f7f4e12367e2b62d 457 Gene3D G3DSA:3.90.1150.10 295 450 5.3E-50 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS24600 8c0b73c088c846c8f7f4e12367e2b62d 457 SUPERFAMILY SSF53383 2 453 2.91E-107 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS24600 8c0b73c088c846c8f7f4e12367e2b62d 457 PIRSF PIRSF001386 1 454 4.1E-175 T 17-03-2017 IPR011166 Beta-eliminating lyase family GO:0009072|GO:0016830 KEGG: 00380+4.1.99.1 SHXM_RS25445 0681468f792dfe0146f4a90516671c46 536 Gene3D G3DSA:3.40.605.10 41 286 1.0E-72 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS25445 0681468f792dfe0146f4a90516671c46 536 SUPERFAMILY SSF53720 38 503 1.11E-141 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS25445 0681468f792dfe0146f4a90516671c46 536 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 272 279 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS25445 0681468f792dfe0146f4a90516671c46 536 Pfam PF00171 Aldehyde dehydrogenase family 44 500 4.8E-143 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS25445 0681468f792dfe0146f4a90516671c46 536 Gene3D G3DSA:3.40.309.10 287 464 2.3E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 SMART SM00382 821 997 0.13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 SMART SM00382 1107 1264 0.6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 SMART SM00382 465 644 0.82 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 TIGRFAM TIGR03924 T7SS_EccC_a: type VII secretion protein EccCa 24 688 5.4E-263 T 17-03-2017 IPR023836 EccCa-like, Actinobacteria SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 TIGRFAM TIGR03925 T7SS_EccC_b: type VII secretion protein EccCb 740 1310 1.4E-230 T 17-03-2017 IPR023837 EccCb-like, Actinobacteria SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 SUPERFAMILY SSF52540 429 654 1.51E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 Pfam PF01580 FtsK/SpoIIIE family 438 556 3.3E-24 T 17-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 Pfam PF01580 FtsK/SpoIIIE family 802 1034 1.8E-45 T 17-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 Gene3D G3DSA:3.40.50.300 820 1002 4.6E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 Gene3D G3DSA:3.40.50.300 1087 1156 2.4E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 Gene3D G3DSA:3.40.50.300 438 658 1.2E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 SUPERFAMILY SSF52540 1059 1250 4.38E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37035 c73a385e60fa7d3ae199bda462dd0e46 1316 SUPERFAMILY SSF52540 773 1015 3.34E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38380 18ffe9e7574eee07d912d7ddea4820b0 184 Gene3D G3DSA:1.10.10.10 35 169 2.0E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38380 18ffe9e7574eee07d912d7ddea4820b0 184 SMART SM00347 58 158 1.1E-17 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS38380 18ffe9e7574eee07d912d7ddea4820b0 184 SUPERFAMILY SSF46785 35 173 4.63E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38380 18ffe9e7574eee07d912d7ddea4820b0 184 Pfam PF01047 MarR family 66 122 1.3E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS49090 1506f8dc927dccfb83eb79568cb0b86e 122 SMART SM00530 64 119 4.8E-14 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49090 1506f8dc927dccfb83eb79568cb0b86e 122 Pfam PF13560 Helix-turn-helix domain 62 116 1.5E-15 T 17-03-2017 SHXM_RS49090 1506f8dc927dccfb83eb79568cb0b86e 122 SUPERFAMILY SSF47413 58 115 1.15E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49090 1506f8dc927dccfb83eb79568cb0b86e 122 Gene3D G3DSA:1.10.260.40 55 115 7.5E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS07675 0aae99d1a643c8616cb930caf49fa33d 407 Gene3D G3DSA:3.40.50.1580 13 256 5.0E-36 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS07675 0aae99d1a643c8616cb930caf49fa33d 407 SUPERFAMILY SSF53167 11 256 1.57E-32 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS07675 0aae99d1a643c8616cb930caf49fa33d 407 Pfam PF01048 Phosphorylase superfamily 13 252 1.4E-20 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS18035 65cc4b888963f18898c8a5ba5129299d 180 SUPERFAMILY SSF160379 1 179 3.14E-50 T 17-03-2017 SHXM_RS18035 65cc4b888963f18898c8a5ba5129299d 180 PIRSF PIRSF008502 1 180 8.8E-47 T 17-03-2017 IPR012545 Protein of unknown function DUF1697 SHXM_RS18035 65cc4b888963f18898c8a5ba5129299d 180 Pfam PF08002 Protein of unknown function (DUF1697) 1 138 2.1E-40 T 17-03-2017 IPR012545 Protein of unknown function DUF1697 SHXM_RS18035 65cc4b888963f18898c8a5ba5129299d 180 Gene3D G3DSA:3.30.70.1280 2 88 3.2E-24 T 17-03-2017 SHXM_RS25025 527a45d3d4b2e3acde40190827899159 311 SUPERFAMILY SSF53474 45 301 1.14E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25025 527a45d3d4b2e3acde40190827899159 311 Gene3D G3DSA:3.40.50.1820 43 301 1.7E-46 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25025 527a45d3d4b2e3acde40190827899159 311 Pfam PF12697 Alpha/beta hydrolase family 70 292 8.2E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 1.7E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 1.7E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 1.7E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 1.7E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 1.7E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 207 227 1.7E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 SUPERFAMILY SSF51735 2 243 2.92E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 1.3E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 1.3E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 1.3E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 10 243 5.1E-51 T 17-03-2017 SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS49055 fbd238617cf0db5e53100d1b59cd2fdb 249 Gene3D G3DSA:3.40.50.720 1 244 1.2E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18220 490ae71267cfe54ed600e8edfb4a1aee 202 Pfam PF01872 RibD C-terminal domain 4 190 1.8E-35 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS18220 490ae71267cfe54ed600e8edfb4a1aee 202 SUPERFAMILY SSF53597 6 186 3.01E-25 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS18220 490ae71267cfe54ed600e8edfb4a1aee 202 Gene3D G3DSA:3.40.430.10 3 200 2.0E-38 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS14250 ae5ac922eafd1d5d06d328a97c1b4f02 295 Gene3D G3DSA:3.40.140.10 151 288 2.9E-54 T 17-03-2017 SHXM_RS14250 ae5ac922eafd1d5d06d328a97c1b4f02 295 Gene3D G3DSA:3.10.20.10 28 120 1.4E-26 T 17-03-2017 SHXM_RS14250 ae5ac922eafd1d5d06d328a97c1b4f02 295 PIRSF PIRSF015626 1 290 8.9E-85 T 17-03-2017 IPR003786 Protein FdhD GO:0016783 SHXM_RS14250 ae5ac922eafd1d5d06d328a97c1b4f02 295 Hamap MF_00187 Sulfurtransferase FdhD [fdhD]. 2 287 34.124 T 17-03-2017 IPR003786 Protein FdhD GO:0016783 SHXM_RS14250 ae5ac922eafd1d5d06d328a97c1b4f02 295 SUPERFAMILY SSF53927 4 286 3.61E-75 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS14250 ae5ac922eafd1d5d06d328a97c1b4f02 295 Pfam PF02634 FdhD/NarQ family 26 286 3.2E-77 T 17-03-2017 IPR003786 Protein FdhD GO:0016783 SHXM_RS31175 af25ea8472c388818510584310615629 108 Hamap MF_01369_B 50S ribosomal protein L23 [rplW]. 16 105 22.535 T 17-03-2017 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31175 af25ea8472c388818510584310615629 108 Gene3D G3DSA:3.30.70.330 14 104 1.9E-37 T 17-03-2017 IPR012677 Nucleotide-binding alpha-beta plait domain GO:0000166 SHXM_RS31175 af25ea8472c388818510584310615629 108 SUPERFAMILY SSF54189 13 105 1.51E-33 T 17-03-2017 IPR012678 Ribosomal protein L23/L15e core domain GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31175 af25ea8472c388818510584310615629 108 Pfam PF00276 Ribosomal protein L23 17 102 3.6E-33 T 17-03-2017 IPR013025 Ribosomal protein L25/L23 GO:0003735|GO:0005840|GO:0006412 SHXM_RS31175 af25ea8472c388818510584310615629 108 ProSitePatterns PS00050 Ribosomal protein L23 signature. 88 103 - T 17-03-2017 IPR001014 Ribosomal protein L23/L25, conserved site Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS21760 09cd5571e0d4fce4d76dec0ff50d29c8 162 TIGRFAM TIGR02133 RPI_actino: ribose 5-phosphate isomerase 1 148 3.0E-73 T 17-03-2017 IPR011860 Ribose 5-phosphate isomerase GO:0004751 SHXM_RS21760 09cd5571e0d4fce4d76dec0ff50d29c8 162 PIRSF PIRSF005384 1 149 2.6E-50 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS21760 09cd5571e0d4fce4d76dec0ff50d29c8 162 Gene3D G3DSA:3.40.1400.10 1 149 8.1E-55 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS21760 09cd5571e0d4fce4d76dec0ff50d29c8 162 Pfam PF02502 Ribose/Galactose Isomerase 3 142 4.3E-46 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS21760 09cd5571e0d4fce4d76dec0ff50d29c8 162 SUPERFAMILY SSF89623 1 152 2.62E-52 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS21760 09cd5571e0d4fce4d76dec0ff50d29c8 162 TIGRFAM TIGR00689 rpiB_lacA_lacB: sugar-phosphate isomerase, RpiB/LacA/LacB family 3 147 3.7E-53 T 17-03-2017 IPR003500 Sugar-phosphate isomerase, RpiB/LacA/LacB family GO:0005975|GO:0016853 KEGG: 00052+5.3.1.26 SHXM_RS37165 8dbdd2ce64a5c5d7a45c270998fe863a 276 Pfam PF13464 Domain of unknown function (DUF4115) 195 267 4.1E-16 T 17-03-2017 IPR025194 Domain of unknown function DUF4115 SHXM_RS37165 8dbdd2ce64a5c5d7a45c270998fe863a 276 Pfam PF13413 Helix-turn-helix domain 24 83 9.8E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS37165 8dbdd2ce64a5c5d7a45c270998fe863a 276 Gene3D G3DSA:1.10.260.40 13 90 1.0E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13100 0afd2ee32067505f780d46b3cdb20c7f 445 SUPERFAMILY SSF48452 214 402 1.55E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS13100 0afd2ee32067505f780d46b3cdb20c7f 445 Gene3D G3DSA:1.25.40.10 213 417 1.6E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03360 05e814a7879716a796aa1031f1a7927a 278 PIRSF PIRSF017393 11 278 2.3E-82 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS03360 05e814a7879716a796aa1031f1a7927a 278 SUPERFAMILY SSF53335 28 258 2.94E-36 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03360 05e814a7879716a796aa1031f1a7927a 278 Pfam PF04672 S-adenosyl methyltransferase 23 278 2.3E-84 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS03360 05e814a7879716a796aa1031f1a7927a 278 Gene3D G3DSA:3.40.50.150 23 278 8.7E-94 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 434 452 2.4E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 417 427 2.4E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 PRINTS PR00344 Bacterial sensor protein C-terminal signature 399 413 2.4E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 SUPERFAMILY SSF47384 239 319 1.96E-15 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 SMART SM00304 201 254 1.5E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 SMART SM00387 364 480 2.6E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 SMART SM00388 255 320 7.7E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 Gene3D G3DSA:3.30.565.10 332 480 4.5E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 364 477 1.2E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 Pfam PF00512 His Kinase A (phospho-acceptor) domain 255 318 1.8E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 SUPERFAMILY SSF55874 323 478 5.11E-29 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 SUPERFAMILY SSF158472 203 251 9.55E-5 T 17-03-2017 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 Gene3D G3DSA:1.10.287.130 245 316 1.2E-13 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS45905 976f523a6e7e809feba72fe36358d455 483 Pfam PF00672 HAMP domain 183 250 2.3E-9 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS22365 6d4014444aed8b3fba6b39be113d8c42 404 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 119 254 2.9E-16 T 17-03-2017 SHXM_RS22365 6d4014444aed8b3fba6b39be113d8c42 404 Gene3D G3DSA:3.40.50.150 43 273 2.1E-39 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22365 6d4014444aed8b3fba6b39be113d8c42 404 SUPERFAMILY SSF53335 25 62 2.97E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22365 6d4014444aed8b3fba6b39be113d8c42 404 SUPERFAMILY SSF53335 97 239 2.97E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 SUPERFAMILY SSF48179 292 467 4.76E-45 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 Pfam PF08125 Mannitol dehydrogenase C-terminal domain 226 416 5.5E-59 T 17-03-2017 IPR013118 Mannitol dehydrogenase, C-terminal GO:0016491|GO:0050662|GO:0055114 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 SUPERFAMILY SSF51735 20 290 1.85E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 Pfam PF01232 Mannitol dehydrogenase Rossmann domain 33 193 5.3E-31 T 17-03-2017 IPR013131 Mannitol dehydrogenase, N-terminal GO:0016491|GO:0055114 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 Gene3D G3DSA:3.40.50.720 21 290 5.7E-95 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 Gene3D G3DSA:1.10.1040.10 292 471 1.6E-52 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 ProSitePatterns PS00974 Mannitol dehydrogenases signature. 227 239 - T 17-03-2017 IPR023027 Mannitol dehydrogenase, conserved site GO:0019594|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 PRINTS PR00084 Mannitol dehydrogenase signature 257 272 1.1E-11 T 17-03-2017 IPR000669 Mannitol dehydrogenase GO:0003824|GO:0008152|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 PRINTS PR00084 Mannitol dehydrogenase signature 34 44 1.1E-11 T 17-03-2017 IPR000669 Mannitol dehydrogenase GO:0003824|GO:0008152|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS44765 9adffc0e5769c4c113eff20eb97ecae2 477 PRINTS PR00084 Mannitol dehydrogenase signature 227 240 1.1E-11 T 17-03-2017 IPR000669 Mannitol dehydrogenase GO:0003824|GO:0008152|GO:0055114 KEGG: 00051+1.1.1.17|MetaCyc: PWY-6531 SHXM_RS08795 a043ed5c14fc016ac427cc1c6cd5d06b 313 SUPERFAMILY SSF53955 53 179 2.14E-28 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS08795 a043ed5c14fc016ac427cc1c6cd5d06b 313 SUPERFAMILY SSF54001 180 295 2.75E-35 T 17-03-2017 SHXM_RS08795 a043ed5c14fc016ac427cc1c6cd5d06b 313 Gene3D G3DSA:3.90.1720.10 180 307 3.9E-38 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS08795 a043ed5c14fc016ac427cc1c6cd5d06b 313 Gene3D G3DSA:1.10.530.10 55 175 4.0E-14 T 17-03-2017 SHXM_RS08795 a043ed5c14fc016ac427cc1c6cd5d06b 313 Pfam PF00877 NlpC/P60 family 200 290 7.3E-23 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS08795 a043ed5c14fc016ac427cc1c6cd5d06b 313 Pfam PF01464 Transglycosylase SLT domain 67 177 7.3E-9 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 Pfam PF00106 short chain dehydrogenase 5 143 5.9E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 Gene3D G3DSA:3.40.50.720 177 273 2.7E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 Gene3D G3DSA:3.40.50.720 4 145 2.7E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 185 204 1.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 1.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 1.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42250 0c3cbe7aefaad412b8e4da8ea4393b02 307 SUPERFAMILY SSF51735 3 253 3.46E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18365 4d5c2cd59daefc73fe4fa685aa904016 156 SUPERFAMILY SSF82784 4 151 2.49E-42 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS18365 4d5c2cd59daefc73fe4fa685aa904016 156 Gene3D G3DSA:3.30.300.20 3 153 5.7E-57 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS18365 4d5c2cd59daefc73fe4fa685aa904016 156 Pfam PF02566 OsmC-like protein 52 147 3.0E-15 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 Pfam PF09190 DALR domain 341 394 6.0E-11 T 17-03-2017 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 Gene3D G3DSA:3.40.50.620 20 303 1.4E-93 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 Hamap MF_00041 Cysteine--tRNA ligase [cysS]. 3 464 35.156 T 17-03-2017 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 SMART SM00840 341 402 1.6E-15 T 17-03-2017 IPR015273 Cysteinyl-tRNA synthetase, class Ia, DALR GO:0000166|GO:0004817|GO:0005524|GO:0005737|GO:0006423 KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 SUPERFAMILY SSF52374 4 310 1.31E-86 T 17-03-2017 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 Pfam PF01406 tRNA synthetases class I (C) catalytic domain 17 311 8.0E-117 T 17-03-2017 IPR032678 tRNA synthetases class I, catalytic domain KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 62 71 2.8E-27 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 190 208 2.8E-27 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 221 242 2.8E-27 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 PRINTS PR00983 Cysteinyl-tRNA synthetase signature 26 37 2.8E-27 T 17-03-2017 IPR024909 Cysteinyl-tRNA synthetase/mycothiol ligase KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 TIGRFAM TIGR00435 cysS: cysteine--tRNA ligase 4 462 5.0E-138 T 17-03-2017 IPR015803 Cysteine-tRNA ligase GO:0004817|GO:0005524|GO:0006423 KEGG: 00970+6.1.1.16 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 SUPERFAMILY SSF47323 330 463 8.24E-32 T 17-03-2017 IPR009080 Aminoacyl-tRNA synthetase, class Ia, anticodon-binding GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS26010 4f095c9c120e7222b0324b6d66645406 466 Gene3D G3DSA:1.20.120.640 304 393 1.9E-20 T 17-03-2017 SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 Gene3D G3DSA:3.40.50.300 90 186 1.9E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 Gene3D G3DSA:3.40.50.300 6 30 1.9E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 ProSitePatterns PS00856 Guanylate kinase-like signature. 42 59 - T 17-03-2017 IPR020590 Guanylate kinase, conserved site KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221 SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 Pfam PF00625 Guanylate kinase 8 185 4.5E-44 T 17-03-2017 IPR008145 Guanylate kinase/L-type calcium channel beta subunit SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 SUPERFAMILY SSF52540 7 185 1.24E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 Gene3D G3DSA:3.30.63.10 38 89 1.8E-26 T 17-03-2017 SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 TIGRFAM TIGR03263 guanyl_kin: guanylate kinase 9 185 3.6E-70 T 17-03-2017 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221|Reactome: R-HSA-2161541|Reactome: R-HSA-499943 SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 Hamap MF_00328 Guanylate kinase [gmk]. 6 188 34.616 T 17-03-2017 IPR017665 Guanylate kinase GO:0004385|GO:0006163 KEGG: 00230+2.7.4.8|MetaCyc: PWY-7221|Reactome: R-HSA-2161541|Reactome: R-HSA-499943 SHXM_RS12335 21f343141d4850fd631f1756ac07e51a 188 SMART SM00072 7 188 2.2E-61 T 17-03-2017 IPR008145 Guanylate kinase/L-type calcium channel beta subunit SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 SUPERFAMILY SSF53092 130 183 3.66E-11 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 SUPERFAMILY SSF53092 13 92 3.66E-11 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 Gene3D G3DSA:3.90.230.10 185 403 7.1E-54 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 SUPERFAMILY SSF55920 184 395 3.66E-57 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 Gene3D G3DSA:3.40.350.10 129 183 1.1E-12 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 Gene3D G3DSA:3.40.350.10 13 94 1.1E-12 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 Pfam PF01321 Creatinase/Prolidase N-terminal domain 13 185 1.8E-11 T 17-03-2017 IPR000587 Creatinase, N-terminal GO:0016787 SHXM_RS00330 bfb6aa7e90ea2d36a1c7028b96a94d6d 410 Pfam PF00557 Metallopeptidase family M24 193 393 3.7E-47 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 Gene3D G3DSA:1.10.260.40 1 49 3.1E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 Pfam PF13377 Periplasmic binding protein-like domain 162 320 1.3E-35 T 17-03-2017 SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 SUPERFAMILY SSF53822 56 323 1.22E-53 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 SMART SM00354 1 67 1.3E-21 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 SUPERFAMILY SSF47413 1 55 4.41E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 Gene3D G3DSA:3.40.50.2300 167 303 1.8E-41 T 17-03-2017 SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 Pfam PF00356 Bacterial regulatory proteins, lacI family 1 44 5.0E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS15905 e54f358055b86dc73d82960cc2419b5f 326 Gene3D G3DSA:3.40.50.2300 50 166 6.8E-28 T 17-03-2017 SHXM_RS05740 bdebb967f594ad374140868ac9d4c9dc 270 Pfam PF13560 Helix-turn-helix domain 5 84 1.0E-17 T 17-03-2017 SHXM_RS05740 bdebb967f594ad374140868ac9d4c9dc 270 SMART SM00530 9 81 8.2E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS05740 bdebb967f594ad374140868ac9d4c9dc 270 Gene3D G3DSA:1.10.260.40 4 80 1.1E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05740 bdebb967f594ad374140868ac9d4c9dc 270 SUPERFAMILY SSF47413 29 79 1.37E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05660 69df5a86da150e93710667158387247f 250 Pfam PF01925 Sulfite exporter TauE/SafE 5 244 3.5E-24 T 17-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 SHXM_RS17095 ffd1046fbffa04474718fdff34765309 208 Pfam PF00293 NUDIX domain 48 164 2.2E-15 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS17095 ffd1046fbffa04474718fdff34765309 208 SUPERFAMILY SSF55811 10 183 1.29E-42 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS17095 ffd1046fbffa04474718fdff34765309 208 Gene3D G3DSA:3.90.79.10 9 184 2.3E-47 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 Gene3D G3DSA:3.40.50.620 147 289 1.9E-19 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 Gene3D G3DSA:3.40.50.620 1 136 5.5E-34 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 Pfam PF00582 Universal stress protein family 150 288 4.2E-12 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 Pfam PF00582 Universal stress protein family 1 136 1.1E-26 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 SUPERFAMILY SSF52402 2 138 6.36E-29 T 17-03-2017 SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 SUPERFAMILY SSF52402 163 289 2.51E-19 T 17-03-2017 SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 PRINTS PR01438 Universal stress protein signature 2 20 1.0E-16 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 PRINTS PR01438 Universal stress protein signature 96 108 1.0E-16 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS49910 a7794c7be908f047cf19626344f64fa5 291 PRINTS PR01438 Universal stress protein signature 114 136 1.0E-16 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 SMART SM00304 271 333 2.6E-6 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 PRINTS PR00344 Bacterial sensor protein C-terminal signature 555 569 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 PRINTS PR00344 Bacterial sensor protein C-terminal signature 573 583 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 PRINTS PR00344 Bacterial sensor protein C-terminal signature 590 608 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 PRINTS PR00344 Bacterial sensor protein C-terminal signature 613 626 2.5E-12 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 SUPERFAMILY SSF47384 328 409 3.73E-19 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 Pfam PF00512 His Kinase A (phospho-acceptor) domain 343 408 1.3E-17 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 Gene3D G3DSA:1.10.287.130 334 394 5.5E-19 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 SMART SM00388 341 408 1.2E-22 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 451 627 3.8E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 Gene3D G3DSA:3.30.565.10 395 486 1.5E-39 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 Gene3D G3DSA:3.30.565.10 554 628 1.5E-39 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 SMART SM00387 451 629 1.3E-35 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 SUPERFAMILY SSF55874 397 486 8.83E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 SUPERFAMILY SSF55874 554 627 8.83E-36 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27415 f8384c4329fc370b1c43c2359b888ad7 660 Pfam PF00672 HAMP domain 254 328 1.6E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS47525 03909a1eb1a994b03ad8fff5ddf71339 192 SUPERFAMILY SSF48498 87 190 7.92E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47525 03909a1eb1a994b03ad8fff5ddf71339 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 4.1E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47525 03909a1eb1a994b03ad8fff5ddf71339 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 4.1E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47525 03909a1eb1a994b03ad8fff5ddf71339 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 67 2.9E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47525 03909a1eb1a994b03ad8fff5ddf71339 192 SUPERFAMILY SSF46689 9 88 3.99E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47525 03909a1eb1a994b03ad8fff5ddf71339 192 Gene3D G3DSA:1.10.357.10 11 192 7.0E-41 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS17305 bed88db4727a3ec04efc1d6b75fdbc1e 256 SUPERFAMILY SSF51735 7 254 5.48E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17305 bed88db4727a3ec04efc1d6b75fdbc1e 256 PIRSF PIRSF000094 2 256 1.5E-81 T 17-03-2017 IPR014358 Enoyl-[acyl-carrier-protein] reductase (NADH) GO:0004318|GO:0006633|GO:0055114 KEGG: 00061+1.3.1.9|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS17305 bed88db4727a3ec04efc1d6b75fdbc1e 256 Gene3D G3DSA:3.40.50.720 3 255 3.4E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17305 bed88db4727a3ec04efc1d6b75fdbc1e 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 252 1.2E-65 T 17-03-2017 SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Pfam PF01011 PQQ enzyme repeat 468 495 3.9E-6 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SUPERFAMILY SSF50998 393 546 1.33E-28 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Pfam PF13360 PQQ-like domain 511 720 1.9E-23 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Pfam PF13360 PQQ-like domain 394 456 2.8E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 24 46 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Gene3D G3DSA:3.30.200.20 12 96 1.2E-16 T 17-03-2017 SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Pfam PF00069 Protein kinase domain 18 264 2.1E-36 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SUPERFAMILY SSF56112 14 264 4.86E-62 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Gene3D G3DSA:2.140.10.10 353 730 1.4E-64 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 406 438 5.7E-7 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 671 702 130.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 582 614 15.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 446 485 1.5E-4 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 494 529 0.0035 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 535 570 9.9E-4 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00564 625 663 1.6E-4 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SUPERFAMILY SSF50998 510 729 3.14E-33 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 SMART SM00220 18 270 1.9E-41 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 Gene3D G3DSA:1.10.510.10 101 267 1.5E-36 T 17-03-2017 SHXM_RS17740 e8e740a040429c20ecf30621418975e8 734 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 136 148 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 Pfam PF00842 Alanine racemase, C-terminal domain 248 280 9.4E-6 T 17-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 TIGRFAM TIGR00492 alr: alanine racemase 11 280 1.6E-67 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 Gene3D G3DSA:3.20.20.10 17 229 1.1E-70 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 SUPERFAMILY SSF50621 243 280 2.55E-9 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 Pfam PF01168 Alanine racemase, N-terminal domain 13 236 2.7E-66 T 17-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 Gene3D G3DSA:2.40.37.10 230 280 3.5E-18 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 SUPERFAMILY SSF51419 13 249 8.72E-63 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 PRINTS PR00992 Alanine racemase signature 167 178 2.0E-44 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 PRINTS PR00992 Alanine racemase signature 33 49 2.0E-44 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 PRINTS PR00992 Alanine racemase signature 264 279 2.0E-44 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 PRINTS PR00992 Alanine racemase signature 209 236 2.0E-44 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 PRINTS PR00992 Alanine racemase signature 69 87 2.0E-44 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 PRINTS PR00992 Alanine racemase signature 130 142 2.0E-44 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 ProSitePatterns PS00395 Alanine racemase pyridoxal-phosphate attachment site. 38 48 - T 17-03-2017 IPR020622 Alanine racemase, pyridoxal-phosphate attachment site KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS00005 5f831f6e16ef36396146b975f83e70ad 281 Hamap MF_01201 Alanine racemase. 6 281 15.278 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS13935 1696f9738c72ce671f724dadc87e8352 327 SUPERFAMILY SSF51412 3 315 5.65E-51 T 17-03-2017 SHXM_RS13935 1696f9738c72ce671f724dadc87e8352 327 Pfam PF03060 Nitronate monooxygenase 5 71 1.9E-11 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS13935 1696f9738c72ce671f724dadc87e8352 327 Pfam PF03060 Nitronate monooxygenase 79 308 1.8E-33 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS13935 1696f9738c72ce671f724dadc87e8352 327 Gene3D G3DSA:3.20.20.70 2 304 3.1E-53 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS45260 f78910ce2ba8066844355dcd0732b444 134 SUPERFAMILY SSF160719 27 127 4.97E-24 T 17-03-2017 SHXM_RS45260 f78910ce2ba8066844355dcd0732b444 134 Pfam PF04965 Gene 25-like lysozyme 27 116 4.0E-19 T 17-03-2017 IPR007048 GpW/Gp25/anti-adapter protein IraD SHXM_RS45260 f78910ce2ba8066844355dcd0732b444 134 Gene3D G3DSA:3.10.450.40 1 127 7.4E-36 T 17-03-2017 SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 247 8.9E-68 T 17-03-2017 SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 130 146 4.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 4.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 4.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 4.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 4.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 4.4E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 SUPERFAMILY SSF51735 6 248 6.36E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 4.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 136 144 4.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 4.8E-13 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 192 1.2E-5 T 17-03-2017 SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 Gene3D G3DSA:3.40.50.720 7 248 2.7E-89 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37790 eb73a0a4991e236906a77e1c5f7e2b16 248 TIGRFAM TIGR01830 3oxo_ACP_reduc: 3-oxoacyl-[acyl-carrier-protein] reductase 9 246 2.7E-96 T 17-03-2017 IPR011284 3-oxoacyl-(acyl-carrier-protein) reductase GO:0004316|GO:0006633|GO:0051287|GO:0055114 KEGG: 00040+1.1.1.10|KEGG: 00061+1.1.1.100|KEGG: 00780+1.1.1.100|MetaCyc: PWY-5367|MetaCyc: PWY-5515|MetaCyc: PWY-5525|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 53 69 7.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 70 85 7.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 89 105 7.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 PRINTS PR00598 Bacterial regulatory protein MarR family signature 119 139 7.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 Pfam PF13463 Winged helix DNA-binding domain 43 102 1.5E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 Gene3D G3DSA:1.10.10.10 6 141 2.6E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 SUPERFAMILY SSF46785 7 141 3.25E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05260 174b7c1b22dd7b491d6541eeaca33436 162 SMART SM00347 30 129 2.6E-11 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 342 351 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 155 170 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 321 336 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 192 214 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 274 285 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 89 100 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 351 362 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00359 B-class P450 signature 138 154 7.3E-28 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 SUPERFAMILY SSF48264 16 404 4.58E-91 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 Pfam PF00067 Cytochrome P450 207 265 3.7E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 Pfam PF00067 Cytochrome P450 18 192 1.0E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 Pfam PF00067 Cytochrome P450 275 372 3.8E-19 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 344 353 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00385 P450 superfamily signature 274 285 4.0E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00385 P450 superfamily signature 239 256 4.0E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00385 P450 superfamily signature 342 351 4.0E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 PRINTS PR00385 P450 superfamily signature 351 362 4.0E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS09710 152401242b590023a25209ec25ec8317 411 Gene3D G3DSA:1.10.630.10 16 404 1.1E-114 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 TIGRFAM TIGR00110 ilvD: dihydroxy-acid dehydratase 18 611 6.6E-240 T 17-03-2017 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 122 132 - T 17-03-2017 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 SUPERFAMILY SSF52016 426 612 4.47E-62 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 Hamap MF_00012 Dihydroxy-acid dehydratase [ilvD]. 4 611 45.284 T 17-03-2017 IPR004404 Dihydroxy-acid dehydratase GO:0004160|GO:0009082 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 Pfam PF00920 Dehydratase family 34 608 5.2E-216 T 17-03-2017 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 SUPERFAMILY SSF143975 4 425 2.22E-133 T 17-03-2017 SHXM_RS30340 4e76e506f039ce2b63195110a158177d 616 ProSitePatterns PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 514 525 - T 17-03-2017 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS05360 f29d27e44776ca99bf1d8f68d341d166 388 SUPERFAMILY SSF51735 213 388 4.69E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05360 f29d27e44776ca99bf1d8f68d341d166 388 SUPERFAMILY SSF51735 3 202 2.72E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05360 f29d27e44776ca99bf1d8f68d341d166 388 Gene3D G3DSA:3.40.50.720 215 388 8.1E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05360 f29d27e44776ca99bf1d8f68d341d166 388 Pfam PF08659 KR domain 215 388 2.1E-58 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05360 f29d27e44776ca99bf1d8f68d341d166 388 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 215 388 4.5E-49 T 17-03-2017 SHXM_RS34230 8a1f60358ee02a83b4207796c7c741bb 606 Gene3D G3DSA:3.40.50.2000 302 503 3.7E-17 T 17-03-2017 SHXM_RS34230 8a1f60358ee02a83b4207796c7c741bb 606 Pfam PF11997 Domain of unknown function (DUF3492) 1 300 2.3E-28 T 17-03-2017 IPR022622 Domain of unknown function DUF3492 SHXM_RS34230 8a1f60358ee02a83b4207796c7c741bb 606 SUPERFAMILY SSF53756 202 522 1.26E-53 T 17-03-2017 SHXM_RS34230 8a1f60358ee02a83b4207796c7c741bb 606 SUPERFAMILY SSF53756 2 87 1.26E-53 T 17-03-2017 SHXM_RS34230 8a1f60358ee02a83b4207796c7c741bb 606 Pfam PF13692 Glycosyl transferases group 1 331 490 3.7E-19 T 17-03-2017 SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 SMART SM00054 418 446 0.14 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 SMART SM00054 382 410 0.93 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 ProSitePatterns PS00018 EF-hand calcium-binding domain. 427 439 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 ProSitePatterns PS00018 EF-hand calcium-binding domain. 391 403 - T 17-03-2017 IPR018247 EF-Hand 1, calcium-binding site SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 Gene3D G3DSA:1.10.238.10 327 446 3.0E-19 T 17-03-2017 IPR011992 EF-hand domain pair SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 27 258 4.0E-37 T 17-03-2017 IPR018713 Domain of unknown function DUF2236 SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 Pfam PF13202 EF hand 422 442 0.0042 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 Pfam PF13202 EF hand 389 405 6.7E-4 T 17-03-2017 IPR002048 EF-hand domain GO:0005509 SHXM_RS40070 3fc2361021fdc3656dfa0c756efe319d 487 SUPERFAMILY SSF47473 327 446 1.11E-18 T 17-03-2017 IPR011992 EF-hand domain pair SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 TIGRFAM TIGR01088 aroQ: 3-dehydroquinate dehydratase, type II 12 149 1.7E-56 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 SUPERFAMILY SSF52304 9 151 9.68E-60 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 ProSitePatterns PS01029 Dehydroquinase class II signature. 15 32 - T 17-03-2017 IPR018509 Dehydroquinase, class II, conserved site GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 ProDom PD004527 LYASE II 3-DEHYDROQUINATE BIOSYNTHESIS DEHYDRATASE TYPE 3-DEHYDROQUINASE DHQASE AMINO AROMATIC 12 141 8.0E-48 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 Hamap MF_00169 3-dehydroquinate dehydratase [aroQ]. 1 157 69.066 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 Gene3D G3DSA:3.40.50.9100 11 153 1.8E-63 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 PIRSF PIRSF001399 8 155 4.4E-60 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS06940 457fa93b598d541e74bc25312349244d 157 Pfam PF01220 Dehydroquinase class II 12 148 1.9E-57 T 17-03-2017 IPR001874 Dehydroquinase, class II GO:0003855 KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 SMART SM00347 26 124 2.6E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 PRINTS PR00598 Bacterial regulatory protein MarR family signature 48 64 2.0E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 PRINTS PR00598 Bacterial regulatory protein MarR family signature 84 100 2.0E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 PRINTS PR00598 Bacterial regulatory protein MarR family signature 114 134 2.0E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 PRINTS PR00598 Bacterial regulatory protein MarR family signature 65 80 2.0E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 SUPERFAMILY SSF46785 5 136 7.14E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 Pfam PF12802 MarR family 31 88 1.3E-8 T 17-03-2017 SHXM_RS20100 40f3a1c90b53cf727e30b868a1f70798 138 Gene3D G3DSA:1.10.10.10 3 136 1.4E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41065 9596bb9c577c6bc1ecbee27b803b7c90 156 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 30 99 4.5E-7 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS41065 9596bb9c577c6bc1ecbee27b803b7c90 156 Gene3D G3DSA:2.30.110.10 14 152 1.6E-41 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41065 9596bb9c577c6bc1ecbee27b803b7c90 156 SUPERFAMILY SSF50475 20 141 1.88E-19 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 Pfam PF00196 Bacterial regulatory proteins, luxR family 158 212 2.5E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 Pfam PF00072 Response regulator receiver domain 26 116 2.1E-5 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 SUPERFAMILY SSF46894 145 218 1.73E-18 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 SMART SM00421 155 212 1.0E-21 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 2.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 2.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 2.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 Gene3D G3DSA:3.40.50.2300 20 117 3.0E-9 T 17-03-2017 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 SUPERFAMILY SSF52172 17 121 1.99E-11 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38240 d1f53eb8214a0a4fa3b0bddd67b6a440 219 Gene3D G3DSA:1.10.10.10 142 217 2.1E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38350 a5869fc29523e2a07d22f8ebcf0d44bd 207 Gene3D G3DSA:3.90.550.10 3 174 6.7E-25 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS38350 a5869fc29523e2a07d22f8ebcf0d44bd 207 Pfam PF09837 Uncharacterized protein conserved in bacteria (DUF2064) 38 149 2.8E-22 T 17-03-2017 IPR018641 Transferase 1, rSAM/selenodomain-associated SHXM_RS38350 a5869fc29523e2a07d22f8ebcf0d44bd 207 SUPERFAMILY SSF53448 3 191 1.63E-30 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS42000 f99e180a0f3c4754177c759ba1d6e4f2 538 Gene3D G3DSA:1.10.390.10 388 528 9.3E-20 T 17-03-2017 SHXM_RS42000 f99e180a0f3c4754177c759ba1d6e4f2 538 Pfam PF01433 Peptidase family M1 103 417 6.0E-28 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS42000 f99e180a0f3c4754177c759ba1d6e4f2 538 SUPERFAMILY SSF55486 293 527 6.04E-44 T 17-03-2017 SHXM_RS42000 f99e180a0f3c4754177c759ba1d6e4f2 538 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 393 405 3.9E-5 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS42000 f99e180a0f3c4754177c759ba1d6e4f2 538 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 374 389 3.9E-5 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS42000 f99e180a0f3c4754177c759ba1d6e4f2 538 SUPERFAMILY SSF63737 91 284 4.05E-27 T 17-03-2017 SHXM_RS06740 03884fdcf9162df8088ae1d7afd2b121 242 Pfam PF06912 Protein of unknown function (DUF1275) 28 223 3.1E-28 T 17-03-2017 IPR010699 Protein of unknown function DUF1275 SHXM_RS34935 e5f6a89d7190166561159c487a7ca933 404 Pfam PF00877 NlpC/P60 family 297 388 1.6E-20 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS34935 e5f6a89d7190166561159c487a7ca933 404 SUPERFAMILY SSF54001 278 396 4.9E-36 T 17-03-2017 SHXM_RS34935 e5f6a89d7190166561159c487a7ca933 404 Gene3D G3DSA:3.90.1720.10 279 395 9.9E-40 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS02250 aa7ac8f0731c98e97ce6f9d5ea2383bb 67 Gene3D G3DSA:3.90.1150.10 3 49 7.7E-11 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS02250 aa7ac8f0731c98e97ce6f9d5ea2383bb 67 Pfam PF12897 Alanine-glyoxylate amino-transferase 2 49 1.2E-14 T 17-03-2017 IPR024551 Aminotransferase, putative SHXM_RS35380 ba0f0354d9fa942c0d7b8bd3fe7deec3 319 Pfam PF03308 ArgK protein 20 280 5.6E-97 T 17-03-2017 SHXM_RS35380 ba0f0354d9fa942c0d7b8bd3fe7deec3 319 TIGRFAM TIGR00750 lao: LAO/AO transport system ATPase 15 312 3.2E-104 T 17-03-2017 IPR005129 SIMIBI class G3E GTPase, ArgK/MeaB GO:0003924|GO:0005525 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS35380 ba0f0354d9fa942c0d7b8bd3fe7deec3 319 Gene3D G3DSA:3.40.50.300 47 251 3.8E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35380 ba0f0354d9fa942c0d7b8bd3fe7deec3 319 SUPERFAMILY SSF52540 3 311 1.2E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 Pfam PF07969 Amidohydrolase family 59 542 3.9E-100 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 Gene3D G3DSA:2.30.40.10 15 97 3.6E-10 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 Gene3D G3DSA:3.20.20.140 198 476 5.5E-29 T 17-03-2017 SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 SUPERFAMILY SSF51338 478 517 2.88E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 SUPERFAMILY SSF51338 12 70 2.88E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 SUPERFAMILY SSF51556 69 130 6.81E-36 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS11570 4810099a8f57f092c4a31e60914ae39e 547 SUPERFAMILY SSF51556 196 476 6.81E-36 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS24045 cc5bc81ea218052b81b6ea30e9f50f46 753 SUPERFAMILY SSF53756 483 714 1.36E-10 T 17-03-2017 SHXM_RS24045 cc5bc81ea218052b81b6ea30e9f50f46 753 SUPERFAMILY SSF53448 2 234 8.66E-47 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24045 cc5bc81ea218052b81b6ea30e9f50f46 753 Gene3D G3DSA:3.90.550.10 1 202 7.6E-43 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24045 cc5bc81ea218052b81b6ea30e9f50f46 753 Pfam PF04464 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase 347 715 2.6E-117 T 17-03-2017 IPR007554 CDP-glycerol glycerophosphotransferase GO:0016020|GO:0047355 SHXM_RS24045 cc5bc81ea218052b81b6ea30e9f50f46 753 Pfam PF00535 Glycosyl transferase family 2 5 129 1.8E-28 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 SUPERFAMILY SSF47240 16 161 1.15E-45 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 PIRSF PIRSF005900 7 165 1.1E-41 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 ProSitePatterns PS00818 Dps protein family signature 1. 46 62 - T 17-03-2017 IPR023188 DNA-binding protein Dps, conserved site GO:0016722|GO:0055114 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 Pfam PF00210 Ferritin-like domain 26 161 3.0E-23 T 17-03-2017 IPR008331 Ferritin/DPS protein domain GO:0006879|GO:0008199 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 141 159 5.6E-12 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 46 62 5.6E-12 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 PRINTS PR01346 Helicobacter neutrophil-activating protein A family signature 70 86 5.6E-12 T 17-03-2017 IPR002177 DNA-binding protein Dps GO:0006950|GO:0055114 SHXM_RS32500 5b8dae9e5f02e1c33dfedbde7da55073 166 Gene3D G3DSA:1.20.1260.10 20 161 8.0E-46 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS45130 0fd6f4f47dcf024c192d7e95e6bbb1e4 172 SMART SM00960 16 106 6.1E-18 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS45130 0fd6f4f47dcf024c192d7e95e6bbb1e4 172 Pfam PF03259 Roadblock/LC7 domain 18 105 9.2E-18 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS45130 0fd6f4f47dcf024c192d7e95e6bbb1e4 172 SUPERFAMILY SSF103196 10 127 3.31E-22 T 17-03-2017 SHXM_RS45130 0fd6f4f47dcf024c192d7e95e6bbb1e4 172 Gene3D G3DSA:3.30.450.30 9 124 1.5E-17 T 17-03-2017 SHXM_RS34095 65a06161fcc26287251a9f02600e521f 221 Pfam PF01596 O-methyltransferase 46 217 5.4E-23 T 17-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 SHXM_RS34095 65a06161fcc26287251a9f02600e521f 221 Gene3D G3DSA:3.40.50.150 23 220 2.1E-51 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS34095 65a06161fcc26287251a9f02600e521f 221 SUPERFAMILY SSF53335 19 220 6.81E-37 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45955 258be20d910e36c7b0fc233af31a965a 402 Pfam PF13439 Glycosyltransferase Family 4 13 186 1.2E-10 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS45955 258be20d910e36c7b0fc233af31a965a 402 Pfam PF00534 Glycosyl transferases group 1 194 351 8.0E-37 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS45955 258be20d910e36c7b0fc233af31a965a 402 SUPERFAMILY SSF53756 2 372 1.02E-70 T 17-03-2017 SHXM_RS45955 258be20d910e36c7b0fc233af31a965a 402 Gene3D G3DSA:3.40.50.2000 193 352 7.3E-28 T 17-03-2017 SHXM_RS30915 922a497de902ddeb2755fa5840b9cf20 447 Pfam PF13796 Putative sensor 37 232 1.0E-43 T 17-03-2017 IPR025828 Putative sensor domain SHXM_RS30915 922a497de902ddeb2755fa5840b9cf20 447 SUPERFAMILY SSF55874 339 446 9.45E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30915 922a497de902ddeb2755fa5840b9cf20 447 Gene3D G3DSA:3.30.565.10 366 446 4.9E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30915 922a497de902ddeb2755fa5840b9cf20 447 Pfam PF07730 Histidine kinase 260 324 4.1E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS47460 0efc78d82058526212f089bc39b17672 120 SMART SM00450 12 108 3.5E-22 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47460 0efc78d82058526212f089bc39b17672 120 SUPERFAMILY SSF52821 6 111 3.67E-29 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47460 0efc78d82058526212f089bc39b17672 120 Gene3D G3DSA:3.40.250.10 4 110 2.8E-27 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS47460 0efc78d82058526212f089bc39b17672 120 Pfam PF00581 Rhodanese-like domain 13 104 2.3E-12 T 17-03-2017 IPR001763 Rhodanese-like domain SHXM_RS36065 63bcb29cd237f08e2a849c34aab60c2e 175 Pfam PF03641 Possible lysine decarboxylase 44 171 2.2E-30 T 17-03-2017 IPR031100 LOG family SHXM_RS36065 63bcb29cd237f08e2a849c34aab60c2e 175 Gene3D G3DSA:3.40.50.450 1 174 8.6E-45 T 17-03-2017 SHXM_RS36065 63bcb29cd237f08e2a849c34aab60c2e 175 SUPERFAMILY SSF102405 1 174 2.9E-43 T 17-03-2017 SHXM_RS36065 63bcb29cd237f08e2a849c34aab60c2e 175 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 2 170 2.1E-36 T 17-03-2017 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 244 5.4E-55 T 17-03-2017 SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 186 0.0032 T 17-03-2017 SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 Gene3D G3DSA:3.40.50.720 4 244 8.2E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 SUPERFAMILY SSF51735 5 245 9.88E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 2.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 131 139 2.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 2.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 209 229 2.1E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 2.1E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 2.1E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 2.1E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 2.1E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30300 4d9eb7ab6b74947bb64f8a3215d52612 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 125 141 2.1E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 Gene3D G3DSA:3.40.50.720 180 326 6.2E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 137 1.5E-26 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 SUPERFAMILY SSF50129 1 188 1.48E-57 T 17-03-2017 IPR011032 GroES-like SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 Pfam PF00107 Zinc-binding dehydrogenase 188 326 1.1E-10 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 SUPERFAMILY SSF51735 154 347 2.96E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 Pfam PF13823 Alcohol dehydrogenase GroES-associated 1 23 2.0E-8 T 17-03-2017 IPR027399 Alcohol dehydrogenase GroES-associated SHXM_RS40005 8459f5e83f75313a124a5f9120414b9e 389 Gene3D G3DSA:3.90.180.10 1 179 1.1E-48 T 17-03-2017 IPR011032 GroES-like SHXM_RS38400 1cb8d3662f799b017c1f23fcb04b753d 342 Pfam PF00296 Luciferase-like monooxygenase 39 314 8.0E-52 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS38400 1cb8d3662f799b017c1f23fcb04b753d 342 SUPERFAMILY SSF51679 14 320 1.47E-59 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS38400 1cb8d3662f799b017c1f23fcb04b753d 342 Gene3D G3DSA:3.20.20.30 12 321 1.1E-65 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16385 a6346312e32cd627580350e264aa130c 346 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 19 83 3.5E-9 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS16385 a6346312e32cd627580350e264aa130c 346 SUPERFAMILY SSF53850 137 264 3.75E-6 T 17-03-2017 SHXM_RS16385 a6346312e32cd627580350e264aa130c 346 SUPERFAMILY SSF46785 17 120 1.48E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16385 a6346312e32cd627580350e264aa130c 346 Gene3D G3DSA:1.10.10.10 17 102 3.6E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27495 091d8c1c3c539f93c481ded3e4202ecd 294 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 54 92 - T 17-03-2017 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SHXM_RS27495 091d8c1c3c539f93c481ded3e4202ecd 294 Gene3D G3DSA:3.40.430.10 209 247 9.0E-4 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS27495 091d8c1c3c539f93c481ded3e4202ecd 294 SUPERFAMILY SSF53927 8 146 8.87E-40 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS27495 091d8c1c3c539f93c481ded3e4202ecd 294 TIGRFAM TIGR00326 eubact_ribD: riboflavin biosynthesis protein RibD 10 158 9.7E-53 T 17-03-2017 IPR004794 Riboflavin biosynthesis protein RibD GO:0008835|GO:0009231|GO:0055114 KEGG: 00040+1.1.1.19|KEGG: 00053+1.1.1.19|KEGG: 00740+3.5.4.26+1.1.1.193|MetaCyc: PWY-5525 SHXM_RS27495 091d8c1c3c539f93c481ded3e4202ecd 294 Gene3D G3DSA:3.40.140.10 8 151 7.7E-27 T 17-03-2017 SHXM_RS27495 091d8c1c3c539f93c481ded3e4202ecd 294 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 8 103 3.3E-16 T 17-03-2017 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 SUPERFAMILY SSF63829 8 279 1.19E-53 T 17-03-2017 SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 15 253 3.1E-62 T 17-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 Gene3D G3DSA:2.120.10.30 4 279 3.1E-71 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 158 178 7.3E-17 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 135 157 7.3E-17 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 94 115 7.3E-17 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS38000 ff4ae2724792bbdd4aba59a48bdfe0e7 299 PRINTS PR01790 Senescence marker protein-30 (SMP30) family signature 196 213 7.3E-17 T 17-03-2017 IPR005511 Senescence marker protein-30 (SMP-30) SHXM_RS49430 8438aefdddd71f5046d68b7c988629ca 216 Gene3D G3DSA:1.20.120.530 97 162 1.2E-5 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS49430 8438aefdddd71f5046d68b7c988629ca 216 SUPERFAMILY SSF46785 14 78 4.99E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49430 8438aefdddd71f5046d68b7c988629ca 216 SUPERFAMILY SSF48008 74 162 4.71E-7 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS49430 8438aefdddd71f5046d68b7c988629ca 216 Pfam PF00392 Bacterial regulatory proteins, gntR family 14 66 2.8E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49430 8438aefdddd71f5046d68b7c988629ca 216 SMART SM00345 13 69 5.8E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS49430 8438aefdddd71f5046d68b7c988629ca 216 Gene3D G3DSA:1.10.10.10 14 70 1.0E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 SUPERFAMILY SSF81296 82 158 4.58E-11 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 Gene3D G3DSA:2.60.40.10 3 75 5.0E-16 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 Gene3D G3DSA:2.60.40.10 83 147 4.0E-13 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 Pfam PF01833 IPT/TIG domain 3 75 1.9E-11 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 Pfam PF01833 IPT/TIG domain 162 244 7.5E-15 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 Pfam PF01833 IPT/TIG domain 82 158 8.6E-11 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 SMART SM00429 78 159 0.24 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 SMART SM00429 161 245 4.9E-7 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 SMART SM00429 1 76 0.24 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 SUPERFAMILY SSF81296 161 244 1.73E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 SUPERFAMILY SSF81296 3 75 1.27E-13 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS31965 07b2baf6c89b5c7081d03bc85ac3db75 250 Gene3D G3DSA:2.60.40.10 148 245 3.7E-18 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 Gene3D G3DSA:3.30.1330.10 55 169 1.2E-18 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 Pfam PF00586 AIR synthase related protein, N-terminal domain 59 167 4.9E-13 T 17-03-2017 IPR016188 PurM-like, N-terminal domain SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 Pfam PF02769 AIR synthase related protein, C-terminal domain 179 325 1.0E-26 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 SUPERFAMILY SSF56042 173 349 1.06E-46 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 TIGRFAM TIGR02124 hypE: hydrogenase expression/formation protein HypE 23 353 4.3E-131 T 17-03-2017 IPR011854 Hydrogenase expression/formation protein HypE SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 SUPERFAMILY SSF55326 25 170 3.66E-26 T 17-03-2017 SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 PIRSF PIRSF005644 19 353 7.1E-120 T 17-03-2017 IPR011854 Hydrogenase expression/formation protein HypE SHXM_RS43485 5cb6396a4452ed1ab8330a6d56fd7fb4 353 Gene3D G3DSA:3.90.650.10 176 332 2.0E-25 T 17-03-2017 IPR010918 AIR synthase-related protein, C-terminal domain SHXM_RS24855 77924d933f5ea40f4e432c3a6801de8d 377 Pfam PF02653 Branched-chain amino acid transport system / permease component 57 336 2.3E-45 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 Gene3D G3DSA:1.10.510.10 92 270 1.5E-39 T 17-03-2017 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 SUPERFAMILY SSF56112 11 328 1.48E-60 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 Pfam PF00069 Protein kinase domain 15 270 1.1E-37 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 21 43 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 Gene3D G3DSA:3.30.200.20 9 85 2.0E-15 T 17-03-2017 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 Pfam PF14219 Domain of unknown function (DUF4328) 436 577 5.5E-30 T 17-03-2017 IPR025565 Domain of unknown function DUF4328 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 134 146 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS29310 d314f466e60bf3bc4080761e1b64cfa2 603 SMART SM00220 15 276 3.4E-46 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SUPERFAMILY SSF46894 2 72 6.8E-10 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Gene3D G3DSA:1.10.10.10 7 94 7.9E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SUPERFAMILY SSF48452 724 923 1.9E-29 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Pfam PF00931 NB-ARC domain 307 546 4.0E-10 T 17-03-2017 IPR002182 NB-ARC GO:0043531 Reactome: R-HSA-111458|Reactome: R-HSA-111459|Reactome: R-HSA-6803207 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Pfam PF03704 Bacterial transcriptional activator domain 98 242 9.7E-29 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM00862 11 91 3.4E-8 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SUPERFAMILY SSF48452 94 267 7.05E-23 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Pfam PF13424 Tetratricopeptide repeat 810 882 1.8E-12 T 17-03-2017 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Pfam PF13424 Tetratricopeptide repeat 731 801 8.4E-9 T 17-03-2017 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM00028 770 803 40.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM00028 730 763 39.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM00028 890 923 37.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM00028 810 843 0.0088 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM00028 850 883 4.4E-4 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Pfam PF00486 Transcriptional regulatory protein, C terminal 18 72 3.3E-7 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 Gene3D G3DSA:1.25.40.10 729 936 2.8E-30 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SMART SM01043 98 243 2.3E-27 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 PRINTS PR00364 Disease resistance protein signature 386 400 8.0E-10 T 17-03-2017 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 PRINTS PR00364 Disease resistance protein signature 474 488 8.0E-10 T 17-03-2017 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 PRINTS PR00364 Disease resistance protein signature 307 322 8.0E-10 T 17-03-2017 SHXM_RS08140 b22583ee19167bfd3a7cbf50304296db 950 SUPERFAMILY SSF52540 270 543 6.43E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 SUPERFAMILY SSF90002 246 336 3.14E-18 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 Gene3D G3DSA:3.30.1220.10 234 337 9.7E-22 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 7 182 1.5E-45 T 17-03-2017 IPR003495 CobW/HypB/UreG, nucleotide-binding domain SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 SMART SM00833 245 336 5.3E-21 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 Gene3D G3DSA:3.40.50.300 4 196 6.5E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain 246 336 2.9E-22 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS46160 c5ed339663e44b85dbf03d843f196100 359 SUPERFAMILY SSF52540 4 192 1.3E-28 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17020 a8c9a1ddaa03575719d6bf89a1449f40 412 Pfam PF13439 Glycosyltransferase Family 4 13 191 1.6E-10 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS17020 a8c9a1ddaa03575719d6bf89a1449f40 412 SUPERFAMILY SSF53756 75 376 3.25E-69 T 17-03-2017 SHXM_RS17020 a8c9a1ddaa03575719d6bf89a1449f40 412 SUPERFAMILY SSF53756 4 45 3.25E-69 T 17-03-2017 SHXM_RS17020 a8c9a1ddaa03575719d6bf89a1449f40 412 Pfam PF00534 Glycosyl transferases group 1 200 357 2.5E-37 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS17020 a8c9a1ddaa03575719d6bf89a1449f40 412 Gene3D G3DSA:3.40.50.2000 199 356 1.0E-23 T 17-03-2017 SHXM_RS19160 af03938a2a110302998046b623f0d422 126 SUPERFAMILY SSF51182 17 120 4.7E-19 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS19160 af03938a2a110302998046b623f0d422 126 Pfam PF12973 ChrR Cupin-like domain 27 117 1.8E-11 T 17-03-2017 IPR025979 ChrR-like cupin domain SHXM_RS19160 af03938a2a110302998046b623f0d422 126 Gene3D G3DSA:2.60.120.10 22 117 5.2E-15 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 SUPERFAMILY SSF52402 9 151 2.93E-21 T 17-03-2017 SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 Pfam PF00582 Universal stress protein family 164 293 1.4E-23 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 Pfam PF00582 Universal stress protein family 9 149 5.7E-15 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 Gene3D G3DSA:3.40.50.620 8 143 2.4E-22 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 Gene3D G3DSA:3.40.50.620 144 293 3.1E-37 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 PRINTS PR01438 Universal stress protein signature 162 180 8.8E-12 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 PRINTS PR01438 Universal stress protein signature 253 265 8.8E-12 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 PRINTS PR01438 Universal stress protein signature 271 293 8.8E-12 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS44235 ceba364fcebbbeba50b0d7354bfddf2f 295 SUPERFAMILY SSF52402 164 293 6.78E-29 T 17-03-2017 SHXM_RS15625 288b44502f8b74ba55e64ef00aecd6e5 452 Gene3D G3DSA:1.10.150.130 55 154 4.5E-14 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS15625 288b44502f8b74ba55e64ef00aecd6e5 452 Pfam PF14659 Phage integrase, N-terminal SAM-like domain 56 110 3.4E-6 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS15625 288b44502f8b74ba55e64ef00aecd6e5 452 Gene3D G3DSA:1.10.443.10 160 299 1.3E-18 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS15625 288b44502f8b74ba55e64ef00aecd6e5 452 Pfam PF00589 Phage integrase family 164 300 1.4E-9 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS15625 288b44502f8b74ba55e64ef00aecd6e5 452 SUPERFAMILY SSF56349 56 299 2.3E-41 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS05925 7732477e81f664b65b6420163f10c9f8 421 PIRSF PIRSF006060 3 416 8.1E-68 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS05925 7732477e81f664b65b6420163f10c9f8 421 Pfam PF13520 Amino acid permease 18 395 1.3E-39 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS18340 6abb059bc9a0c00d93ad6dc2366a5665 121 SUPERFAMILY SSF141734 14 114 4.05E-46 T 17-03-2017 SHXM_RS18340 6abb059bc9a0c00d93ad6dc2366a5665 121 Pfam PF01502 Phosphoribosyl-AMP cyclohydrolase 40 112 2.1E-33 T 17-03-2017 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 SHXM_RS18340 6abb059bc9a0c00d93ad6dc2366a5665 121 Hamap MF_01021 Phosphoribosyl-AMP cyclohydrolase [hisI]. 14 117 31.054 T 17-03-2017 IPR026660 Phosphoribosyl-AMP cyclohydrolase GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 SHXM_RS18340 6abb059bc9a0c00d93ad6dc2366a5665 121 ProDom PD002610 PHOSPHORIBOSYL-AMP BIOSYNTHESIS CYCLOHYDROLASE HYDROLASE HISTIDINE AMINO-ACID PRA-CH PHOSPHORIBOSYL-ATP BIFUNCTIONAL INCLUDES: 63 117 1.0E-21 T 17-03-2017 IPR002496 Phosphoribosyl-AMP cyclohydrolase domain GO:0000105|GO:0004635 KEGG: 00340+3.5.4.19 SHXM_RS13330 8621c6ba2742ed1346356387f147848f 365 Gene3D G3DSA:1.10.600.10 60 364 1.5E-80 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13330 8621c6ba2742ed1346356387f147848f 365 ProSitePatterns PS00723 Polyprenyl synthases signature 1. 110 124 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS13330 8621c6ba2742ed1346356387f147848f 365 SUPERFAMILY SSF48576 48 363 8.06E-74 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13330 8621c6ba2742ed1346356387f147848f 365 Pfam PF00348 Polyprenyl synthetase 71 298 7.1E-52 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS46455 fb02aba10205cdc94fa8dc825a256a44 295 SUPERFAMILY SSF161098 23 287 6.54E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46455 fb02aba10205cdc94fa8dc825a256a44 295 Gene3D G3DSA:1.10.3720.10 28 287 8.2E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46455 fb02aba10205cdc94fa8dc825a256a44 295 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 136 285 3.3E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 Gene3D G3DSA:3.50.50.60 185 256 1.8E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 Gene3D G3DSA:3.50.50.60 360 406 1.8E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 Gene3D G3DSA:3.50.50.60 25 128 1.8E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 Gene3D G3DSA:3.30.9.10 257 356 6.4E-12 T 17-03-2017 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 Gene3D G3DSA:3.30.9.10 134 184 6.4E-12 T 17-03-2017 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 SUPERFAMILY SSF51905 22 131 2.36E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 SUPERFAMILY SSF51905 186 312 2.36E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04450 785902dfc425dd77fc51d91f2a0a6813 464 Pfam PF01266 FAD dependent oxidoreductase 37 398 8.4E-50 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS49665 43b4d8768e1c5ed1e99a657eaaae4f18 239 SUPERFAMILY SSF48498 90 230 2.31E-26 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS49665 43b4d8768e1c5ed1e99a657eaaae4f18 239 Pfam PF00440 Bacterial regulatory proteins, tetR family 28 74 7.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS49665 43b4d8768e1c5ed1e99a657eaaae4f18 239 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 91 229 1.3E-10 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS49665 43b4d8768e1c5ed1e99a657eaaae4f18 239 Gene3D G3DSA:1.10.357.10 88 231 8.0E-49 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS49665 43b4d8768e1c5ed1e99a657eaaae4f18 239 Gene3D G3DSA:1.10.10.60 11 81 5.4E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49665 43b4d8768e1c5ed1e99a657eaaae4f18 239 SUPERFAMILY SSF46689 25 88 2.74E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 Pfam PF01297 Zinc-uptake complex component A periplasmic 41 327 7.5E-69 T 17-03-2017 IPR006127 Periplasmic solute binding protein, ZnuA-like GO:0030001|GO:0046872 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00690 Adhesin family signature 69 82 9.9E-6 T 17-03-2017 IPR006128 Adhesion lipoprotein GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00690 Adhesin family signature 38 56 9.9E-6 T 17-03-2017 IPR006128 Adhesion lipoprotein GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00690 Adhesin family signature 269 287 9.9E-6 T 17-03-2017 IPR006128 Adhesion lipoprotein GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 Gene3D G3DSA:3.40.50.1980 210 329 7.5E-34 T 17-03-2017 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 SUPERFAMILY SSF53807 37 328 2.4E-71 T 17-03-2017 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00691 Adhesin B signature 63 81 1.1E-7 T 17-03-2017 IPR006129 Adhesin B GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00691 Adhesin B signature 265 282 1.1E-7 T 17-03-2017 IPR006129 Adhesin B GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00691 Adhesin B signature 38 59 1.1E-7 T 17-03-2017 IPR006129 Adhesin B GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 PRINTS PR00691 Adhesin B signature 307 325 1.1E-7 T 17-03-2017 IPR006129 Adhesin B GO:0007155 SHXM_RS21020 70f1c94bf99687b9a5fbcf3c526029f4 331 Gene3D G3DSA:3.40.50.1980 24 209 2.8E-45 T 17-03-2017 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 SUPERFAMILY SSF51445 8 261 9.07E-110 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 SUPERFAMILY SSF51445 301 430 9.07E-110 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 SUPERFAMILY SSF51445 481 740 9.07E-110 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:1.10.10.470 572 653 6.4E-18 T 17-03-2017 IPR013797 Maltooligosyl trehalose synthase, N-terminal MetaCyc: PWY-2661 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 TIGRFAM TIGR02401 trehalose_TreY: malto-oligosyltrehalose synthase 8 845 2.6E-254 T 17-03-2017 IPR012767 Malto-oligosyltrehalose synthase MetaCyc: PWY-2661 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:3.20.20.80 301 342 6.8E-64 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:3.20.20.80 667 772 6.8E-64 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:3.20.20.80 7 97 6.8E-64 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:3.20.20.80 531 571 6.8E-64 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:3.20.20.80 231 261 6.8E-64 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Pfam PF00128 Alpha amylase, catalytic domain 30 99 6.5E-13 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 SMART SM00642 8 736 7.0E-7 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS38520 8c7395a89dbcda1ce2d2c71bcc724974 846 Gene3D G3DSA:3.30.1590.10 98 215 1.1E-36 T 17-03-2017 SHXM_RS04115 4b13366e93b62f1c8eef9272f730886e 895 Pfam PF00754 F5/8 type C domain 317 425 1.1E-6 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS04115 4b13366e93b62f1c8eef9272f730886e 895 SUPERFAMILY SSF49785 320 426 5.95E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04115 4b13366e93b62f1c8eef9272f730886e 895 Gene3D G3DSA:2.60.120.260 331 438 5.0E-8 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04115 4b13366e93b62f1c8eef9272f730886e 895 SMART SM00860 522 650 2.9E-7 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS04115 4b13366e93b62f1c8eef9272f730886e 895 Gene3D G3DSA:3.40.1580.10 520 548 1.4E-6 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS04115 4b13366e93b62f1c8eef9272f730886e 895 SUPERFAMILY SSF160631 516 648 3.14E-10 T 17-03-2017 SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 49 63 4.0E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 63 79 4.0E-5 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 Gene3D G3DSA:1.10.10.10 30 96 3.9E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 SMART SM00345 30 89 7.8E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 SUPERFAMILY SSF53383 86 484 1.05E-68 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 SUPERFAMILY SSF46785 22 98 3.06E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 Gene3D G3DSA:3.40.640.10 157 375 3.0E-40 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 Pfam PF00155 Aminotransferase class I and II 130 415 4.8E-12 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS27640 cf18e6fe690a74b56089ee437510d4dd 508 Pfam PF00392 Bacterial regulatory proteins, gntR family 30 89 1.8E-17 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS36005 7231df99ecc491a856d7aa2dea2171d8 219 Pfam PF03458 UPF0126 domain 13 87 7.4E-18 T 17-03-2017 IPR005115 Uncharacterised domain UPF0126 SHXM_RS36005 7231df99ecc491a856d7aa2dea2171d8 219 Pfam PF03458 UPF0126 domain 99 173 5.2E-20 T 17-03-2017 IPR005115 Uncharacterised domain UPF0126 SHXM_RS06685 1522a15f98c4d484a64185c4ba79ec41 280 Pfam PF01063 Amino-transferase class IV 43 245 2.3E-25 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS06685 1522a15f98c4d484a64185c4ba79ec41 280 SUPERFAMILY SSF56752 44 254 1.96E-32 T 17-03-2017 IPR001544 Aminotransferase class IV GO:0003824|GO:0008152 Reactome: R-HSA-70895 SHXM_RS06685 1522a15f98c4d484a64185c4ba79ec41 280 Gene3D G3DSA:3.20.10.10 149 255 2.8E-18 T 17-03-2017 SHXM_RS07095 cb85de56fc3cff7c8c50f96a87d16b4d 261 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 102 122 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS07095 cb85de56fc3cff7c8c50f96a87d16b4d 261 SUPERFAMILY SSF52096 9 233 4.02E-67 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS07095 cb85de56fc3cff7c8c50f96a87d16b4d 261 Gene3D G3DSA:3.90.226.10 9 238 2.9E-68 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS07095 cb85de56fc3cff7c8c50f96a87d16b4d 261 Pfam PF00378 Enoyl-CoA hydratase/isomerase 15 210 6.6E-39 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS45620 4616f3f209bdc4300ccf33819a1f1159 335 Pfam PF03747 ADP-ribosylglycohydrolase 10 306 7.0E-59 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS45620 4616f3f209bdc4300ccf33819a1f1159 335 SUPERFAMILY SSF101478 3 329 5.36E-65 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS50490 3238bdd85e58b015dd6fa33083f3ec24 280 SUPERFAMILY SSF109854 17 166 5.95E-12 T 17-03-2017 SHXM_RS50490 3238bdd85e58b015dd6fa33083f3ec24 280 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 27 160 1.2E-7 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS50490 3238bdd85e58b015dd6fa33083f3ec24 280 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 26 221 5.4E-20 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS25150 7b66069187b34d371f3da7f42b0004a9 198 Pfam PF13563 2'-5' RNA ligase superfamily 13 158 2.7E-20 T 17-03-2017 SHXM_RS25150 7b66069187b34d371f3da7f42b0004a9 198 Gene3D G3DSA:3.90.1140.10 8 176 8.2E-23 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS25150 7b66069187b34d371f3da7f42b0004a9 198 SUPERFAMILY SSF55144 5 174 7.06E-30 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS46830 0a458bf708636aef01500733bf1fcac2 481 Gene3D G3DSA:3.40.50.1820 144 260 5.3E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46830 0a458bf708636aef01500733bf1fcac2 481 Gene3D G3DSA:3.40.50.1820 358 451 5.3E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46830 0a458bf708636aef01500733bf1fcac2 481 Pfam PF10605 3HB-oligomer hydrolase (3HBOH) 359 475 1.3E-9 T 17-03-2017 IPR016582 D-(-)-3-hydroxybutyrate oligomer hydrolase, putative GO:0005615|GO:0019605|GO:0047989 KEGG: 00650+3.1.1.22 SHXM_RS46830 0a458bf708636aef01500733bf1fcac2 481 SUPERFAMILY SSF53474 143 282 2.74E-13 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46830 0a458bf708636aef01500733bf1fcac2 481 SUPERFAMILY SSF53474 359 433 2.74E-13 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46830 0a458bf708636aef01500733bf1fcac2 481 Pfam PF07519 Tannase and feruloyl esterase 121 250 5.0E-9 T 17-03-2017 IPR011118 Tannase/feruloyl esterase MetaCyc: PWY-6784 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 PRINTS PR00116 Arginase signature 121 136 1.9E-14 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 PRINTS PR00116 Arginase signature 234 263 1.9E-14 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 ProSitePatterns PS01053 Arginase family signature. 237 258 - T 17-03-2017 IPR020855 Ureohydrolase, manganese-binding site GO:0016813|GO:0046872 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 PIRSF PIRSF036979 10 312 1.2E-108 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 SUPERFAMILY SSF52768 14 311 4.14E-102 T 17-03-2017 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 Pfam PF00491 Arginase family 34 305 7.7E-92 T 17-03-2017 IPR006035 Ureohydrolase GO:0046872 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 TIGRFAM TIGR01230 agmatinase: agmatinase 31 306 1.5E-72 T 17-03-2017 IPR005925 Agmatinase-related KEGG: 00330+3.5.3.11|MetaCyc: PWY-40|MetaCyc: PWY-6305|Reactome: R-HSA-351143 SHXM_RS04430 3a69edb638a111df2a5d1b18553690b7 320 Gene3D G3DSA:3.40.800.10 8 314 1.6E-119 T 17-03-2017 IPR023696 Ureohydrolase domain SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 Gene3D G3DSA:3.40.50.720 8 248 7.6E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 9.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 9.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 11 28 9.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 9.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 9.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 9.0E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 144 172 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 SUPERFAMILY SSF51735 9 248 5.79E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 246 8.5E-57 T 17-03-2017 SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 145 4.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 4.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS06195 54a8af4ee7e4cc59f9bf7b0dd1c0d967 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 4.7E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 SUPERFAMILY SSF55486 218 542 1.04E-80 T 17-03-2017 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 368 542 1.4E-54 T 17-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 218 365 1.5E-48 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 78 125 1.6E-18 T 17-03-2017 IPR011096 FTP domain SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 Gene3D G3DSA:3.10.170.10 217 369 3.3E-46 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 Gene3D G3DSA:1.10.390.10 370 542 2.3E-53 T 17-03-2017 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 377 388 2.2E-19 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 356 372 2.2E-19 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 320 340 2.2E-19 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS35795 4dd3b8d88c9e0bf5ea4df36629bc0760 543 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 444 460 2.2E-19 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01950 LanC-like protein superfamily signature 221 237 7.7E-21 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01950 LanC-like protein superfamily signature 155 170 7.7E-21 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01950 LanC-like protein superfamily signature 344 357 7.7E-21 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01950 LanC-like protein superfamily signature 407 424 7.7E-21 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01950 LanC-like protein superfamily signature 294 314 7.7E-21 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01950 LanC-like protein superfamily signature 50 68 7.7E-21 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 Pfam PF05147 Lanthionine synthetase C-like protein 53 424 7.8E-45 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 154 170 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 294 317 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 94 110 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 176 192 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 242 262 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 271 285 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 218 242 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 343 363 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 PRINTS PR01955 Frankia sp. LanC-like protein signature 51 66 7.1E-52 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 SUPERFAMILY SSF158745 51 428 1.07E-65 T 17-03-2017 SHXM_RS12270 e891b6f00af867b76e812bf81865a905 445 SMART SM01260 47 443 1.6E-56 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS39330 713de530ed42764f40d120995654017c 301 SUPERFAMILY SSF47413 30 81 6.76E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39330 713de530ed42764f40d120995654017c 301 Pfam PF13560 Helix-turn-helix domain 6 85 3.0E-17 T 17-03-2017 SHXM_RS39330 713de530ed42764f40d120995654017c 301 SMART SM00530 10 82 1.2E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS39330 713de530ed42764f40d120995654017c 301 Gene3D G3DSA:1.10.260.40 4 80 7.2E-23 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33855 f749961d3ccc45d691857caf021d6f6c 324 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 41 84 2.0E-6 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS33855 f749961d3ccc45d691857caf021d6f6c 324 Gene3D G3DSA:1.10.3720.10 117 321 8.9E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33855 f749961d3ccc45d691857caf021d6f6c 324 SUPERFAMILY SSF161098 118 307 2.88E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33855 f749961d3ccc45d691857caf021d6f6c 324 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 140 324 4.4E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS21925 6b42ace9bb287e7b1a9b3f6f0c70f393 301 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 294 3.1E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS21925 6b42ace9bb287e7b1a9b3f6f0c70f393 301 Gene3D G3DSA:1.10.3720.10 26 288 9.0E-69 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS21925 6b42ace9bb287e7b1a9b3f6f0c70f393 301 SUPERFAMILY SSF161098 29 301 6.35E-72 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 SUPERFAMILY SSF51735 132 280 2.2E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 54 68 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 SUPERFAMILY SSF50129 1 167 1.79E-43 T 17-03-2017 IPR011032 GroES-like SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 Gene3D G3DSA:3.40.50.720 160 265 2.6E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 Pfam PF00107 Zinc-binding dehydrogenase 169 280 6.6E-10 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 Gene3D G3DSA:3.90.180.10 1 159 7.6E-46 T 17-03-2017 IPR011032 GroES-like SHXM_RS05130 4e005b529a1a15cc98f5faa64239b846 320 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 20 127 9.2E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS35300 0c4eedf2e81207202e363a60b2b986c2 260 Gene3D G3DSA:3.40.50.300 2 229 2.3E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35300 0c4eedf2e81207202e363a60b2b986c2 260 SMART SM00382 32 216 2.2E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35300 0c4eedf2e81207202e363a60b2b986c2 260 ProSitePatterns PS00211 ABC transporters family signature. 139 153 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS35300 0c4eedf2e81207202e363a60b2b986c2 260 Pfam PF00005 ABC transporter 24 166 4.2E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS35300 0c4eedf2e81207202e363a60b2b986c2 260 SUPERFAMILY SSF52540 3 229 1.33E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02735 4d728dabf91db8319e9aecc6db51aee7 116 Pfam PF01638 HxlR-like helix-turn-helix 20 108 3.2E-27 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS02735 4d728dabf91db8319e9aecc6db51aee7 116 Gene3D G3DSA:1.10.10.10 4 113 1.6E-37 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02735 4d728dabf91db8319e9aecc6db51aee7 116 SUPERFAMILY SSF46785 9 113 8.65E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 Gene3D G3DSA:1.20.140.10 204 366 1.3E-35 T 17-03-2017 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 221 364 2.6E-26 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 Gene3D G3DSA:2.40.110.10 112 203 2.8E-29 T 17-03-2017 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 Gene3D G3DSA:1.10.540.10 8 109 4.9E-20 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 SUPERFAMILY SSF56645 8 214 6.54E-52 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 SUPERFAMILY SSF47203 221 365 1.77E-30 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 112 202 1.5E-18 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS39585 ddc9a761379b15c7e8dcbfb3399e38b7 371 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 8 109 1.6E-13 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS13290 3ef7152cb0ef3594ca59b074eff346cd 274 Pfam PF13350 Tyrosine phosphatase family 16 272 1.7E-61 T 17-03-2017 IPR026893 Tyrosine/serine-protein phosphatase IphP-type SHXM_RS13290 3ef7152cb0ef3594ca59b074eff346cd 274 Gene3D G3DSA:3.90.190.10 137 195 1.4E-17 T 17-03-2017 IPR029021 Protein-tyrosine phosphatase-like SHXM_RS13290 3ef7152cb0ef3594ca59b074eff346cd 274 Gene3D G3DSA:3.90.190.10 18 102 1.4E-17 T 17-03-2017 IPR029021 Protein-tyrosine phosphatase-like SHXM_RS13290 3ef7152cb0ef3594ca59b074eff346cd 274 SUPERFAMILY SSF52799 19 272 7.64E-48 T 17-03-2017 IPR029021 Protein-tyrosine phosphatase-like SHXM_RS16995 c39bbb832ae2102d084ae11eed97d995 284 Pfam PF06386 Gas vesicle synthesis protein GvpL/GvpF 6 266 2.6E-61 T 17-03-2017 IPR009430 Gas vesicle protein GvpL/GvpF GO:0031411|GO:0031412 SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 PRINTS PR01438 Universal stress protein signature 126 148 3.5E-11 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 PRINTS PR01438 Universal stress protein signature 108 120 3.5E-11 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 PRINTS PR01438 Universal stress protein signature 10 28 3.5E-11 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 Pfam PF00582 Universal stress protein family 12 148 5.5E-20 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 Pfam PF00582 Universal stress protein family 162 298 4.7E-20 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 SUPERFAMILY SSF52402 12 151 6.2E-25 T 17-03-2017 SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 SUPERFAMILY SSF52402 162 298 1.93E-17 T 17-03-2017 SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 Gene3D G3DSA:3.40.50.620 159 298 8.4E-22 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS07995 1ebb47e42fafe20e0cf43138b0527c23 300 Gene3D G3DSA:3.40.50.620 5 148 5.8E-28 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 TIGRFAM TIGR01003 PTS_HPr_family: phosphocarrier, HPr family 1 82 6.4E-25 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 ProSitePatterns PS00369 PTS HPR domain histidine phosphorylation site signature. 13 20 - T 17-03-2017 IPR001020 Phosphotransferase system, HPr histidine phosphorylation site SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 Gene3D G3DSA:3.30.1340.10 1 82 4.5E-26 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 PRINTS PR00107 Phosphocarrier protein signature 39 54 7.3E-12 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 PRINTS PR00107 Phosphocarrier protein signature 54 71 7.3E-12 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 PRINTS PR00107 Phosphocarrier protein signature 13 29 7.3E-12 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 Pfam PF00381 PTS HPr component phosphorylation site 3 82 7.3E-25 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS00860 82605438ff2d30274c600422ee827a4c 92 SUPERFAMILY SSF55594 1 83 5.23E-21 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 Pfam PF13360 PQQ-like domain 530 681 1.3E-17 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 Gene3D G3DSA:1.10.510.10 110 265 5.4E-11 T 17-03-2017 SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SUPERFAMILY SSF50998 538 680 8.11E-21 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SMART SM00220 15 263 4.4E-4 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SMART SM00564 556 586 13.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SMART SM00564 367 398 0.65 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SMART SM00564 595 626 10.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SMART SM00564 640 672 160.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SMART SM00564 515 543 210.0 T 17-03-2017 IPR018391 Pyrrolo-quinoline quinone beta-propeller repeat SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SUPERFAMILY SSF50998 352 544 2.2E-12 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 Gene3D G3DSA:2.140.10.10 556 701 5.3E-20 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 Gene3D G3DSA:2.140.10.10 308 545 1.9E-12 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS37050 974ac30360343be77d98dc6adeb863b9 708 SUPERFAMILY SSF56112 12 253 1.26E-18 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS42930 909d9a80c6be41ff1887d59027f6604e 126 Gene3D G3DSA:3.10.180.10 4 119 1.7E-12 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS42930 909d9a80c6be41ff1887d59027f6604e 126 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 117 7.5E-5 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS42930 909d9a80c6be41ff1887d59027f6604e 126 SUPERFAMILY SSF54593 1 121 1.14E-16 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 Pfam PF00106 short chain dehydrogenase 12 204 4.3E-47 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 149 177 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 SUPERFAMILY SSF51735 11 239 5.07E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 85 96 2.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 162 181 2.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 142 150 2.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 Gene3D G3DSA:3.40.50.720 10 246 1.1E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 1.5E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.5E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 181 1.5E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS19565 82e312efc1e02224a762ce920eccdc8c 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 136 152 1.5E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17515 c4e43079394c27d1c281d7b816d10c3d 327 Hamap MF_00024 Cobalamin biosynthesis protein CbiB [cbiB]. 1 315 93.514 T 17-03-2017 IPR004485 Cobalamin biosynthesis CobD/CbiB GO:0009236|GO:0016021|GO:0048472 SHXM_RS17515 c4e43079394c27d1c281d7b816d10c3d 327 TIGRFAM TIGR00380 cobD: cobalamin biosynthesis protein CobD 18 297 6.6E-51 T 17-03-2017 IPR004485 Cobalamin biosynthesis CobD/CbiB GO:0009236|GO:0016021|GO:0048472 SHXM_RS17515 c4e43079394c27d1c281d7b816d10c3d 327 Pfam PF03186 CobD/Cbib protein 13 293 4.2E-87 T 17-03-2017 IPR004485 Cobalamin biosynthesis CobD/CbiB GO:0009236|GO:0016021|GO:0048472 SHXM_RS14865 b715c70307049de68ebe6d793fef0ab5 431 Gene3D G3DSA:3.90.1150.10 307 422 1.2E-34 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS14865 b715c70307049de68ebe6d793fef0ab5 431 SUPERFAMILY SSF53383 12 422 5.09E-104 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS14865 b715c70307049de68ebe6d793fef0ab5 431 Gene3D G3DSA:3.40.640.10 56 306 2.0E-66 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS14865 b715c70307049de68ebe6d793fef0ab5 431 Pfam PF00202 Aminotransferase class-III 18 421 1.2E-84 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS26990 088bb5b76ac0a6f1621a603dc86b6a6d 220 SUPERFAMILY SSF55811 37 195 1.26E-25 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS26990 088bb5b76ac0a6f1621a603dc86b6a6d 220 Pfam PF00293 NUDIX domain 40 123 2.1E-11 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS26990 088bb5b76ac0a6f1621a603dc86b6a6d 220 Gene3D G3DSA:3.90.79.10 37 202 3.7E-35 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS48395 f76fca15cf594d15ae57c41d538e841b 268 SUPERFAMILY SSF161098 28 256 9.03E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48395 f76fca15cf594d15ae57c41d538e841b 268 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 62 264 1.8E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48395 f76fca15cf594d15ae57c41d538e841b 268 Gene3D G3DSA:1.10.3720.10 34 264 8.1E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 SMART SM00825 Beta-ketoacyl synthase 5 396 2.9E-11 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 SUPERFAMILY SSF53901 615 755 7.97E-6 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 SUPERFAMILY SSF53901 4 240 1.23E-34 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 Gene3D G3DSA:3.40.47.10 470 650 9.6E-19 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 Gene3D G3DSA:3.40.47.10 254 398 7.8E-46 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 SUPERFAMILY SSF53901 207 399 2.81E-54 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 Gene3D G3DSA:3.40.47.10 4 243 1.4E-34 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 SUPERFAMILY SSF53901 422 644 3.29E-24 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 471 599 4.3E-10 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 4 233 2.9E-25 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS11985 30f28dbdb05d41fffa055938451135f3 765 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 243 357 1.4E-29 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 Pfam PF02031 Streptomyces extracellular neutral proteinase (M7) family 43 169 3.6E-30 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 107 131 3.0E-22 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 48 74 3.0E-22 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 132 156 3.0E-22 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 159 173 3.0E-22 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 SUPERFAMILY SSF55486 42 168 7.34E-21 T 17-03-2017 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 Gene3D G3DSA:3.40.390.10 43 171 3.5E-27 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 PIRSF PIRSF016573 7 184 8.6E-35 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS07800 6882a7c692d425bde30cdea20202da82 186 ProDom PD016028 PROTEASE METALLOPROTEASE EXTRACELLULAR NEUTRAL SMALL METAL-BINDING ZINC HYDROLASE SNAPALYSIN ZYMOGEN 49 167 6.0E-53 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS12695 b4f1beffcafc55197411b20f854881e2 281 SUPERFAMILY SSF55729 18 113 6.62E-11 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12695 b4f1beffcafc55197411b20f854881e2 281 Gene3D G3DSA:3.40.630.30 115 274 2.9E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12695 b4f1beffcafc55197411b20f854881e2 281 Gene3D G3DSA:3.40.630.30 18 114 4.2E-10 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12695 b4f1beffcafc55197411b20f854881e2 281 SUPERFAMILY SSF55729 127 273 9.43E-22 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12695 b4f1beffcafc55197411b20f854881e2 281 Pfam PF00583 Acetyltransferase (GNAT) family 193 270 1.7E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS12695 b4f1beffcafc55197411b20f854881e2 281 Pfam PF00583 Acetyltransferase (GNAT) family 27 105 3.4E-6 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS17840 53df33ba04c999da6c84e9c28a55d0ef 308 Gene3D G3DSA:3.40.50.300 2 221 3.5E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17840 53df33ba04c999da6c84e9c28a55d0ef 308 SMART SM00382 31 217 1.1E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17840 53df33ba04c999da6c84e9c28a55d0ef 308 ProSitePatterns PS00211 ABC transporters family signature. 133 147 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17840 53df33ba04c999da6c84e9c28a55d0ef 308 Pfam PF00005 ABC transporter 23 161 6.7E-23 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17840 53df33ba04c999da6c84e9c28a55d0ef 308 SUPERFAMILY SSF52540 4 221 3.31E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24265 cb041ed35131d3dc247f261e0b6ded75 542 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 145 305 5.2E-43 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24265 cb041ed35131d3dc247f261e0b6ded75 542 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 145 305 6.3E-39 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24265 cb041ed35131d3dc247f261e0b6ded75 542 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 411 502 2.9E-10 T 17-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain SHXM_RS03890 7e1a0ae874639a51ece37e86c7f12909 286 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 100 279 2.5E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03890 7e1a0ae874639a51ece37e86c7f12909 286 SUPERFAMILY SSF161098 15 282 3.92E-69 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03890 7e1a0ae874639a51ece37e86c7f12909 286 Gene3D G3DSA:1.10.3720.10 13 272 2.3E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23430 f50ecb0fa3d624f4e402903c22fa0fb5 112 Hamap MF_00302 ATP-dependent Clp protease adapter protein ClpS [clpS]. 21 112 17.42 T 17-03-2017 IPR022935 ATP-dependent Clp protease adaptor protein ClpS SHXM_RS23430 f50ecb0fa3d624f4e402903c22fa0fb5 112 Pfam PF02617 ATP-dependent Clp protease adaptor protein ClpS 37 106 2.8E-22 T 17-03-2017 IPR003769 Adaptor protein ClpS, core GO:0030163 Reactome: R-HSA-983168 SHXM_RS23430 f50ecb0fa3d624f4e402903c22fa0fb5 112 SUPERFAMILY SSF54736 34 109 4.81E-25 T 17-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SHXM_RS23430 f50ecb0fa3d624f4e402903c22fa0fb5 112 Gene3D G3DSA:3.30.1390.10 23 111 4.2E-29 T 17-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SHXM_RS49005 2b681a77bee7972986667f41fd629c43 217 Pfam PF01983 Guanylyl transferase CofC like 11 170 5.4E-7 T 17-03-2017 IPR002835 2-phospho-L-lactate guanylyltransferase, CofC GO:0016779 KEGG: 00680+2.7.7.68|MetaCyc: PWY-5198 SHXM_RS49005 2b681a77bee7972986667f41fd629c43 217 TIGRFAM TIGR03552 F420_cofC: 2-phospho-L-lactate guanylyltransferase 11 208 3.3E-35 T 17-03-2017 IPR002835 2-phospho-L-lactate guanylyltransferase, CofC GO:0016779 KEGG: 00680+2.7.7.68|MetaCyc: PWY-5198 SHXM_RS49005 2b681a77bee7972986667f41fd629c43 217 Gene3D G3DSA:3.90.550.10 11 173 3.8E-20 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS49005 2b681a77bee7972986667f41fd629c43 217 SUPERFAMILY SSF53448 9 209 3.41E-22 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 SUPERFAMILY SSF55120 184 373 6.58E-43 T 17-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 Pfam PF01479 S4 domain 139 185 1.6E-13 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 Pfam PF00849 RNA pseudouridylate synthase 201 331 1.8E-23 T 17-03-2017 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 Gene3D G3DSA:3.10.290.10 137 197 6.5E-22 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 SUPERFAMILY SSF55174 123 203 5.69E-13 T 17-03-2017 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 SMART SM00363 139 200 9.1E-10 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 TIGRFAM TIGR00093 TIGR00093: pseudouridine synthase 204 362 4.6E-42 T 17-03-2017 IPR000748 Pseudouridine synthase, RsuA/RluB/E/F GO:0001522|GO:0003723|GO:0009451|GO:0016866 SHXM_RS17060 0df9cae06ab0e7b597fd540eb71abe7a 375 ProSitePatterns PS01149 Rsu family of pseudouridine synthase signature. 237 251 - T 17-03-2017 IPR018496 Pseudouridine synthase, RsuA/RluB/E/F, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0016866 SHXM_RS14660 17a2c974b6f8a21d81f43513bc45f07f 247 Gene3D G3DSA:3.90.470.20 32 146 1.4E-28 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS14660 17a2c974b6f8a21d81f43513bc45f07f 247 Pfam PF01648 4'-phosphopantetheinyl transferase superfamily 137 200 1.3E-11 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS14660 17a2c974b6f8a21d81f43513bc45f07f 247 SUPERFAMILY SSF56214 30 130 6.8E-21 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS14660 17a2c974b6f8a21d81f43513bc45f07f 247 SUPERFAMILY SSF56214 137 241 1.83E-18 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS14660 17a2c974b6f8a21d81f43513bc45f07f 247 Gene3D G3DSA:3.90.470.20 147 199 3.8E-15 T 17-03-2017 IPR008278 4'-phosphopantetheinyl transferase superfamily GO:0000287|GO:0008897 KEGG: 00770+2.7.8.7|MetaCyc: PWY-6012|MetaCyc: PWY-6012-1|Reactome: R-HSA-199220 SHXM_RS08855 47c12a4be83b716c5484330e71bc7f68 202 Pfam PF01609 Transposase DDE domain 5 142 2.3E-12 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS08855 47c12a4be83b716c5484330e71bc7f68 202 SUPERFAMILY SSF53098 2 182 3.41E-22 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS05975 9ef2bf6df4c60f3130abd1b5a1f89972 388 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain 245 360 3.1E-18 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS05975 9ef2bf6df4c60f3130abd1b5a1f89972 388 Gene3D G3DSA:3.30.1220.10 237 360 7.1E-7 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS05975 9ef2bf6df4c60f3130abd1b5a1f89972 388 SUPERFAMILY SSF90002 245 307 4.97E-9 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS05975 9ef2bf6df4c60f3130abd1b5a1f89972 388 SUPERFAMILY SSF90002 334 360 4.97E-9 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS05975 9ef2bf6df4c60f3130abd1b5a1f89972 388 SMART SM00833 244 360 4.3E-37 T 17-03-2017 IPR011629 Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal SHXM_RS05975 9ef2bf6df4c60f3130abd1b5a1f89972 388 Gene3D G3DSA:3.40.50.300 68 213 5.4E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14605 ca632071650fb20309a1d50d9846502d 184 SUPERFAMILY SSF52317 1 175 1.78E-40 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14605 ca632071650fb20309a1d50d9846502d 184 TIGRFAM TIGR01382 PfpI: intracellular protease, PfpI family 6 173 2.5E-44 T 17-03-2017 IPR006286 Peptidase C56, PfpI SHXM_RS14605 ca632071650fb20309a1d50d9846502d 184 Gene3D G3DSA:3.40.50.880 1 177 8.7E-49 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14605 ca632071650fb20309a1d50d9846502d 184 Pfam PF01965 DJ-1/PfpI family 1 174 8.8E-49 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS33495 1a10a7ebf552c7488859a3674b147701 420 PRINTS PR00758 Arsenical pump membrane protein signature 107 131 6.1E-12 T 17-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 SHXM_RS33495 1a10a7ebf552c7488859a3674b147701 420 PRINTS PR00758 Arsenical pump membrane protein signature 352 377 6.1E-12 T 17-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 SHXM_RS33495 1a10a7ebf552c7488859a3674b147701 420 Pfam PF02040 Arsenical pump membrane protein 10 406 5.8E-23 T 17-03-2017 IPR000802 Arsenical pump membrane protein, ArsB GO:0015105|GO:0015700|GO:0016021 SHXM_RS17145 a7edb435bd2553055498ad287ebf54d2 115 Gene3D G3DSA:3.30.1050.10 9 115 6.2E-14 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS17145 a7edb435bd2553055498ad287ebf54d2 115 SUPERFAMILY SSF55718 8 115 5.42E-14 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS08460 7f904418c99ac5e7b1b23acf15d0b920 219 Pfam PF01730 UreF 29 169 5.2E-20 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS08460 7f904418c99ac5e7b1b23acf15d0b920 219 Hamap MF_01385 Urease accessory protein UreF [ureF]. 1 219 18.027 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS08460 7f904418c99ac5e7b1b23acf15d0b920 219 PIRSF PIRSF009467 1 219 2.8E-49 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS34080 2ed5891cc7431d775e951d8d3c1c5e21 198 TIGRFAM TIGR00624 tag: DNA-3-methyladenine glycosylase I 15 193 1.1E-70 T 17-03-2017 IPR004597 DNA-3-methyladenine glycosylase I GO:0006284|GO:0008725 SHXM_RS34080 2ed5891cc7431d775e951d8d3c1c5e21 198 Gene3D G3DSA:1.10.340.30 15 195 7.6E-69 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS34080 2ed5891cc7431d775e951d8d3c1c5e21 198 Pfam PF03352 Methyladenine glycosylase 25 193 7.5E-66 T 17-03-2017 IPR005019 Methyladenine glycosylase GO:0006284|GO:0008725 SHXM_RS34080 2ed5891cc7431d775e951d8d3c1c5e21 198 SUPERFAMILY SSF48150 14 196 3.92E-65 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS47095 44837c5c3f4d205d7018676b94f20abd 329 SUPERFAMILY SSF56645 1 132 4.84E-17 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS47095 44837c5c3f4d205d7018676b94f20abd 329 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 7 116 5.2E-13 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS47095 44837c5c3f4d205d7018676b94f20abd 329 SUPERFAMILY SSF47203 192 326 4.19E-33 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS47095 44837c5c3f4d205d7018676b94f20abd 329 Gene3D G3DSA:1.10.540.10 1 116 2.8E-13 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS47095 44837c5c3f4d205d7018676b94f20abd 329 Gene3D G3DSA:1.20.140.10 192 326 9.4E-32 T 17-03-2017 SHXM_RS47095 44837c5c3f4d205d7018676b94f20abd 329 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 190 319 6.2E-26 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS06400 161ee83437ec7659f12c8b20b61e1738 145 SUPERFAMILY SSF54427 3 137 6.13E-18 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06400 161ee83437ec7659f12c8b20b61e1738 145 Gene3D G3DSA:3.10.450.50 2 141 3.2E-37 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06400 161ee83437ec7659f12c8b20b61e1738 145 Pfam PF12680 SnoaL-like domain 16 131 8.2E-14 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS19270 9652a7074c37629cf2995cea303a4992 340 Gene3D G3DSA:1.10.3720.10 105 336 9.3E-70 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19270 9652a7074c37629cf2995cea303a4992 340 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 132 329 1.2E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19270 9652a7074c37629cf2995cea303a4992 340 SUPERFAMILY SSF161098 99 327 1.11E-65 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38090 25c010f6b3094b554ded77eb57e9d8e4 192 Gene3D G3DSA:1.10.357.10 56 187 2.5E-6 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS38090 25c010f6b3094b554ded77eb57e9d8e4 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 1.9E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38090 25c010f6b3094b554ded77eb57e9d8e4 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 1.9E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38090 25c010f6b3094b554ded77eb57e9d8e4 192 SUPERFAMILY SSF46689 8 75 3.45E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38090 25c010f6b3094b554ded77eb57e9d8e4 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 57 4.5E-19 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38090 25c010f6b3094b554ded77eb57e9d8e4 192 Gene3D G3DSA:1.10.10.60 9 55 7.3E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 SUPERFAMILY SSF46785 9 139 5.88E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 SMART SM00347 27 128 1.4E-24 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 88 104 1.4E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 69 84 1.4E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 PRINTS PR00598 Bacterial regulatory protein MarR family signature 118 138 1.4E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 Gene3D G3DSA:1.10.10.10 7 139 4.1E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45190 64b4838c74621f214e3de847cf2a1969 146 Pfam PF12802 MarR family 32 91 1.2E-12 T 17-03-2017 SHXM_RS37610 b00bef9566e3c551f403b9d70ca82d50 100 Pfam PF13834 Domain of unknown function (DUF4193) 1 99 1.1E-44 T 17-03-2017 IPR025242 Protein of unknown function DUF4193 SHXM_RS02875 c573c2226f2f241b767148cb3596171a 192 Pfam PF04978 Protein of unknown function (DUF664) 18 188 2.5E-43 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS02875 c573c2226f2f241b767148cb3596171a 192 SUPERFAMILY SSF109854 4 187 3.66E-36 T 17-03-2017 SHXM_RS02875 c573c2226f2f241b767148cb3596171a 192 Gene3D G3DSA:1.20.120.450 4 190 4.5E-46 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS41905 adefdbec012dae11bd71221398b98c26 433 SUPERFAMILY SSF51395 52 243 8.55E-95 T 17-03-2017 SHXM_RS41905 adefdbec012dae11bd71221398b98c26 433 SUPERFAMILY SSF51395 278 430 8.55E-95 T 17-03-2017 SHXM_RS41905 adefdbec012dae11bd71221398b98c26 433 ProSitePatterns PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 328 334 - T 17-03-2017 IPR008259 FMN-dependent alpha-hydroxy acid dehydrogenase, active site GO:0016491|GO:0055114 SHXM_RS41905 adefdbec012dae11bd71221398b98c26 433 Gene3D G3DSA:3.20.20.70 52 431 6.9E-125 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS41905 adefdbec012dae11bd71221398b98c26 433 Pfam PF01070 FMN-dependent dehydrogenase 62 431 3.6E-125 T 17-03-2017 IPR000262 FMN-dependent dehydrogenase GO:0016491 SHXM_RS41905 adefdbec012dae11bd71221398b98c26 433 PIRSF PIRSF000138 32 432 9.4E-125 T 17-03-2017 IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent GO:0010181|GO:0016491|GO:0055114 SHXM_RS28520 dfee67f552680dfedd0b9da5ed0f7572 141 SUPERFAMILY SSF54427 8 136 9.48E-35 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS28520 dfee67f552680dfedd0b9da5ed0f7572 141 Pfam PF07366 SnoaL-like polyketide cyclase 12 136 2.7E-37 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS28520 dfee67f552680dfedd0b9da5ed0f7572 141 Gene3D G3DSA:3.10.450.50 8 136 2.0E-37 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 SUPERFAMILY SSF51905 8 270 1.99E-59 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 SUPERFAMILY SSF51905 260 462 2.07E-20 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 Gene3D G3DSA:3.50.50.60 6 218 1.4E-67 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 Gene3D G3DSA:3.50.50.60 320 485 4.2E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 132 140 5.2E-7 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 10 32 5.2E-7 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 171 195 5.2E-7 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS32525 26d3ffbc3fe779eba13f589d7be6ea05 509 Pfam PF00743 Flavin-binding monooxygenase-like 10 216 6.8E-19 T 17-03-2017 IPR020946 Flavin monooxygenase-like GO:0004499|GO:0050660|GO:0050661|GO:0055114 SHXM_RS32590 88d244ca2a7959286e5ab265473482df 276 SMART SM00530 24 79 6.7E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS32590 88d244ca2a7959286e5ab265473482df 276 SUPERFAMILY SSF47413 19 75 2.4E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS32590 88d244ca2a7959286e5ab265473482df 276 Gene3D G3DSA:1.10.260.40 21 67 1.1E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 Pfam PF00570 HRDC domain 247 313 3.8E-14 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 Gene3D G3DSA:1.10.150.80 253 301 1.1E-4 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 Gene3D G3DSA:3.30.420.10 44 212 2.4E-7 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 SUPERFAMILY SSF47819 225 336 7.2E-26 T 17-03-2017 IPR010997 HRDC-like GO:0000166|GO:0003824|GO:0044237 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 Pfam PF01612 3'-5' exonuclease 44 205 5.9E-33 T 17-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 SUPERFAMILY SSF53098 27 242 1.45E-49 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 SMART SM00341 244 324 2.7E-17 T 17-03-2017 IPR002121 HRDC domain GO:0003676|GO:0005622 SHXM_RS38235 0fa75944f37556fdd559ff75e21f452b 425 SMART SM00474 39 205 5.9E-38 T 17-03-2017 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SHXM_RS30500 185eb2c6cfc89a9d3c663513432c9f1a 262 Pfam PF01636 Phosphotransferase enzyme family 140 219 1.7E-6 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS30500 185eb2c6cfc89a9d3c663513432c9f1a 262 Gene3D G3DSA:3.90.1200.10 153 223 3.3E-7 T 17-03-2017 SHXM_RS30500 185eb2c6cfc89a9d3c663513432c9f1a 262 SUPERFAMILY SSF56112 32 227 1.9E-12 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS05920 29895f99de53921c4050edf5490529f6 306 SUPERFAMILY SSF53448 8 210 1.13E-36 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS05920 29895f99de53921c4050edf5490529f6 306 Gene3D G3DSA:3.90.550.10 6 213 2.0E-30 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS05920 29895f99de53921c4050edf5490529f6 306 Pfam PF00535 Glycosyl transferase family 2 10 165 1.7E-17 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 Pfam PF00970 Oxidoreductase FAD-binding domain 159 259 4.8E-12 T 17-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 SUPERFAMILY SSF46458 1 144 1.13E-30 T 17-03-2017 IPR009050 Globin-like SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 Gene3D G3DSA:2.40.30.10 154 261 9.9E-33 T 17-03-2017 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 Pfam PF00175 Oxidoreductase NAD-binding domain 272 371 3.8E-9 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 SUPERFAMILY SSF52343 263 391 1.13E-29 T 17-03-2017 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 Gene3D G3DSA:3.40.50.80 264 392 1.0E-25 T 17-03-2017 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 SUPERFAMILY SSF63380 154 261 1.97E-27 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 Gene3D G3DSA:1.10.490.10 2 145 4.1E-42 T 17-03-2017 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 PRINTS PR00410 Phenol hydroxylase reductase family signature 186 198 3.4E-7 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 PRINTS PR00410 Phenol hydroxylase reductase family signature 357 365 3.4E-7 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 PRINTS PR00410 Phenol hydroxylase reductase family signature 269 288 3.4E-7 T 17-03-2017 IPR001221 Phenol hydroxylase reductase GO:0055114 SHXM_RS02910 f95b1e04ea2ea0b18318d8e361fd75a4 403 Pfam PF00042 Globin 8 104 5.8E-5 T 17-03-2017 IPR000971 Globin GO:0019825|GO:0020037 SHXM_RS31290 0478ad6403b1f0167bc38c632efc622f 37 ProDom PD002101 RIBOSOMAL L36 RIBONUCLEOPROTEIN 50S CHLOROPLAST PLASTID B SUBUNIT DIRECT SEQUENCING 9 37 2.0E-9 T 17-03-2017 SHXM_RS31290 0478ad6403b1f0167bc38c632efc622f 37 ProSitePatterns PS00828 Ribosomal protein L36 signature. 11 36 - T 17-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31290 0478ad6403b1f0167bc38c632efc622f 37 Hamap MF_00251 50S ribosomal protein L36 [rpmJ]. 1 37 17.021 T 17-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31290 0478ad6403b1f0167bc38c632efc622f 37 TIGRFAM TIGR01022 rpmJ_bact: ribosomal protein bL36 1 37 9.0E-22 T 17-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31290 0478ad6403b1f0167bc38c632efc622f 37 Pfam PF00444 Ribosomal protein L36 1 37 4.2E-18 T 17-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31290 0478ad6403b1f0167bc38c632efc622f 37 SUPERFAMILY SSF57840 1 37 3.53E-16 T 17-03-2017 IPR000473 Ribosomal protein L36 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS29125 cd256319f19cf96f463a260ba1ae2ff5 178 Pfam PF10722 Putative bacterial sensory transduction regulator 30 155 8.3E-18 T 17-03-2017 IPR019660 Putative sensory transduction regulator YbjN SHXM_RS45165 2982799a122f3913e72b5611ea487fcb 263 Pfam PF04307 LexA-binding, inner membrane-associated putative hydrolase 1 254 1.4E-34 T 17-03-2017 IPR007404 LexA-binding, inner membrane-associated putative hydrolase SHXM_RS37680 164a55a5325bfebb393c57fbda69735c 142 Gene3D G3DSA:3.30.450.30 6 128 5.6E-20 T 17-03-2017 SHXM_RS37680 164a55a5325bfebb393c57fbda69735c 142 SMART SM00960 10 101 3.3E-15 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS37680 164a55a5325bfebb393c57fbda69735c 142 SUPERFAMILY SSF103196 5 130 1.28E-23 T 17-03-2017 SHXM_RS37680 164a55a5325bfebb393c57fbda69735c 142 Pfam PF03259 Roadblock/LC7 domain 13 100 2.7E-18 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 TIGRFAM TIGR02891 CtaD_CoxA: cytochrome c oxidase, subunit I 25 529 2.3E-213 T 17-03-2017 IPR014241 Cytochrome c oxidase, subunit I bacterial type GO:0004129|GO:0005507|GO:0005886|GO:0006810|GO:0022900|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 Gene3D G3DSA:1.20.210.10 16 543 8.6E-196 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 SUPERFAMILY SSF81442 22 532 2.35E-177 T 17-03-2017 IPR023616 Cytochrome c oxidase, subunit I domain GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 Pfam PF00115 Cytochrome C and Quinol oxidase polypeptide I 33 477 1.1E-146 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 231 252 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 298 313 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 98 122 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 141 153 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 202 221 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 71 94 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 355 373 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 433 454 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 24 49 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 173 191 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 383 402 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 252 273 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 PRINTS PR01165 Cytochrome c oxidase subunit I signature 320 341 1.9E-102 T 17-03-2017 IPR000883 Cytochrome c oxidase subunit I GO:0004129|GO:0005506|GO:0009055|GO:0009060|GO:0016021|GO:0020037|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS22035 d8a4ac3882d9d1f4e4f26a7390855cd0 580 ProSitePatterns PS00077 Heme-copper oxidase catalytic subunit, copper B binding region signature. 254 308 - T 17-03-2017 IPR023615 Cytochrome c oxidase, subunit I, copper-binding site GO:0004129|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279|Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS26690 d596c7c0b1f10e04da437ef81e887562 103 Pfam PF12840 Helix-turn-helix domain 8 64 1.5E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26690 d596c7c0b1f10e04da437ef81e887562 103 SMART SM00418 8 88 2.9E-5 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26690 d596c7c0b1f10e04da437ef81e887562 103 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 44 59 1.6E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26690 d596c7c0b1f10e04da437ef81e887562 103 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 10 25 1.6E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS26690 d596c7c0b1f10e04da437ef81e887562 103 Gene3D G3DSA:1.10.10.10 4 94 2.0E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26690 d596c7c0b1f10e04da437ef81e887562 103 SUPERFAMILY SSF46785 3 90 1.59E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36410 6c7c678279345fe0cd994a6d6fbe7a95 276 SUPERFAMILY SSF53613 19 274 1.56E-77 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS36410 6c7c678279345fe0cd994a6d6fbe7a95 276 TIGRFAM TIGR00097 HMP-P_kinase: hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 20 271 1.1E-93 T 17-03-2017 IPR004399 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase GO:0008972|GO:0009228 KEGG: 00730+2.7.1.49|MetaCyc: PWY-6910|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SHXM_RS36410 6c7c678279345fe0cd994a6d6fbe7a95 276 Gene3D G3DSA:3.40.1190.20 19 271 1.3E-99 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS36410 6c7c678279345fe0cd994a6d6fbe7a95 276 Pfam PF08543 Phosphomethylpyrimidine kinase 27 270 4.4E-91 T 17-03-2017 IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase Reactome: R-HSA-964975 SHXM_RS10780 f02a39dc3750fa4a0adfa03a86548e41 262 Pfam PF00550 Phosphopantetheine attachment site 198 262 8.7E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10780 f02a39dc3750fa4a0adfa03a86548e41 262 ProSitePatterns PS00012 Phosphopantetheine attachment site. 222 237 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS10780 f02a39dc3750fa4a0adfa03a86548e41 262 SUPERFAMILY SSF47336 191 262 1.83E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS10780 f02a39dc3750fa4a0adfa03a86548e41 262 Gene3D G3DSA:1.10.1200.10 192 262 2.6E-15 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS28145 8e93a673f19245cc0de0c3ef63f341b3 180 Hamap MF_00630 UPF0232 protein . 1 166 30.662 T 17-03-2017 IPR023007 Uncharacterised protein family UPF0232, actinobacteria SHXM_RS28145 8e93a673f19245cc0de0c3ef63f341b3 180 Pfam PF05258 Protein of unknown function (DUF721) 65 154 1.7E-25 T 17-03-2017 IPR007922 Protein of unknown function DUF721/UPF0232 SHXM_RS10480 77b86b62bcefc74d7c5beba7c78ac435 252 Pfam PF09335 SNARE associated Golgi protein 78 195 1.0E-24 T 17-03-2017 IPR032816 SNARE associated Golgi protein SHXM_RS20960 b4f19aaa864fa16a4b8855feefbe60f9 734 Pfam PF00656 Caspase domain 12 256 1.0E-17 T 17-03-2017 SHXM_RS20960 b4f19aaa864fa16a4b8855feefbe60f9 734 Gene3D G3DSA:3.40.50.1460 10 111 7.9E-6 T 17-03-2017 IPR029030 Caspase-like domain SHXM_RS20960 b4f19aaa864fa16a4b8855feefbe60f9 734 SUPERFAMILY SSF52129 77 256 1.15E-6 T 17-03-2017 IPR029030 Caspase-like domain SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 318 405 3.7E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 SUPERFAMILY SSF55874 281 403 1.13E-19 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 Pfam PF07730 Histidine kinase 208 275 6.1E-17 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 PIRSF PIRSF037434 25 411 1.7E-82 T 17-03-2017 IPR017205 Signal transduction histidine kinase, ChrS SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 SMART SM00387 313 406 1.1E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 366 384 3.8E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 350 364 3.8E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 PRINTS PR00344 Bacterial sensor protein C-terminal signature 390 403 3.8E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS22200 2b00eea1335b116b4feca0ced993f62c 414 Gene3D G3DSA:3.30.565.10 312 405 2.7E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37720 f786ec136e9e44a4768da226461b7c4b 262 Gene3D G3DSA:1.10.10.10 195 249 9.7E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37720 f786ec136e9e44a4768da226461b7c4b 262 SUPERFAMILY SSF46894 195 251 7.48E-9 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS37720 f786ec136e9e44a4768da226461b7c4b 262 SMART SM00421 195 244 0.0015 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18490 5f007007983c553a2b6a00f918962539 543 Pfam PF09423 PhoD-like phosphatase 150 507 2.1E-118 T 17-03-2017 IPR018946 Alkaline phosphatase D-related SHXM_RS18490 5f007007983c553a2b6a00f918962539 543 Gene3D G3DSA:3.60.21.10 170 514 3.9E-13 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18490 5f007007983c553a2b6a00f918962539 543 Pfam PF16655 PhoD-like phosphatase, N-terminal domain 40 137 4.2E-32 T 17-03-2017 IPR032093 Phospholipase D, N-terminal SHXM_RS18490 5f007007983c553a2b6a00f918962539 543 SUPERFAMILY SSF56300 146 512 7.59E-28 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 Hamap MF_00093 Peptide chain release factor 1 [prfA]. 1 359 37.836 T 17-03-2017 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 Pfam PF03462 PCRF domain 11 206 3.5E-65 T 17-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 Gene3D G3DSA:3.30.160.20 213 291 7.9E-35 T 17-03-2017 IPR014720 Double-stranded RNA-binding domain SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 SUPERFAMILY SSF75620 8 355 6.54E-126 T 17-03-2017 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 ProSitePatterns PS00745 Prokaryotic-type class I peptide chain release factors signature. 230 246 - T 17-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 Pfam PF00472 RF-1 domain 214 323 1.7E-41 T 17-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 SMART SM00937 63 181 1.7E-52 T 17-03-2017 IPR005139 Peptide chain release factor GO:0005737|GO:0006415|GO:0016149 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 Gene3D G3DSA:1.20.58.410 6 82 9.3E-15 T 17-03-2017 SHXM_RS35195 8eed05955df0a9b4f38612d3e531e716 359 TIGRFAM TIGR00019 prfA: peptide chain release factor 1 2 356 1.2E-149 T 17-03-2017 IPR004373 Peptide chain release factor 1 GO:0005737|GO:0006415|GO:0016149 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 Pfam PF01266 FAD dependent oxidoreductase 6 357 1.0E-64 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 Gene3D G3DSA:3.30.9.10 210 318 9.1E-17 T 17-03-2017 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 SUPERFAMILY SSF54373 226 318 1.15E-21 T 17-03-2017 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 Gene3D G3DSA:3.50.50.60 5 84 9.6E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 Gene3D G3DSA:3.50.50.60 143 209 9.6E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 Gene3D G3DSA:3.50.50.60 320 377 9.6E-46 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 SUPERFAMILY SSF51905 5 225 1.04E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 SUPERFAMILY SSF51905 320 377 1.04E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18690 f4825bcee5e29345ad4cd5e1395c37d9 391 TIGRFAM TIGR02352 thiamin_ThiO: glycine oxidase ThiO 8 362 2.4E-118 T 17-03-2017 IPR012727 Glycine oxidase ThiO GO:0016491|GO:0050660 SHXM_RS06315 f172aaaf2e8e6ecc02a9c6b77fcf8e33 422 Gene3D G3DSA:3.40.50.410 42 226 2.3E-14 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS06315 f172aaaf2e8e6ecc02a9c6b77fcf8e33 422 SMART SM00327 39 222 5.2E-15 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS06315 f172aaaf2e8e6ecc02a9c6b77fcf8e33 422 Pfam PF13519 von Willebrand factor type A domain 42 158 5.7E-13 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS06315 f172aaaf2e8e6ecc02a9c6b77fcf8e33 422 SUPERFAMILY SSF53300 40 226 6.23E-24 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 SUPERFAMILY SSF51735 12 252 1.22E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 1.3E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 1.3E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 1.3E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 4.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 4.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 4.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 14 31 4.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 4.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 4.3E-46 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 Gene3D G3DSA:3.40.50.720 8 252 2.2E-87 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13190 0c692df62deb75119b6ef35e3675a2e5 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 252 1.3E-70 T 17-03-2017 SHXM_RS47335 e49a9f17a5546e04c8aec7f9ad5fcd18 254 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 95 240 2.8E-13 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS47335 e49a9f17a5546e04c8aec7f9ad5fcd18 254 Pfam PF00440 Bacterial regulatory proteins, tetR family 38 80 9.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47335 e49a9f17a5546e04c8aec7f9ad5fcd18 254 Gene3D G3DSA:1.10.10.60 26 90 2.3E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47335 e49a9f17a5546e04c8aec7f9ad5fcd18 254 SUPERFAMILY SSF46689 28 90 9.48E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47335 e49a9f17a5546e04c8aec7f9ad5fcd18 254 Gene3D G3DSA:1.10.357.10 91 240 2.2E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47335 e49a9f17a5546e04c8aec7f9ad5fcd18 254 SUPERFAMILY SSF48498 101 244 2.45E-24 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47010 3cfb1280c4de28f19eb4be59a0bf8720 342 Gene3D G3DSA:3.90.1200.10 102 241 2.6E-10 T 17-03-2017 SHXM_RS47010 3cfb1280c4de28f19eb4be59a0bf8720 342 SUPERFAMILY SSF56112 17 243 4.8E-29 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 SUPERFAMILY SSF50331 253 363 4.37E-18 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 Pfam PF03459 TOBE domain 301 361 7.7E-11 T 17-03-2017 IPR005116 Transport-associated OB, type 1 SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 ProSitePatterns PS00211 ABC transporters family signature. 151 165 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 Gene3D G3DSA:3.40.50.300 32 251 8.5E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 Pfam PF00005 ABC transporter 33 178 5.3E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 SUPERFAMILY SSF52540 26 253 2.66E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 Gene3D G3DSA:2.40.50.100 291 358 2.4E-14 T 17-03-2017 SHXM_RS28760 d821b493bc73628f41e95fe6b1e76f6a 365 SMART SM00382 39 228 5.1E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS45625 b30c40451095da0a90ee2c354788eb9a 497 PIRSF PIRSF002744 1 483 1.1E-102 T 17-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 SHXM_RS45625 b30c40451095da0a90ee2c354788eb9a 497 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 19 431 1.3E-53 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 Gene3D G3DSA:1.10.10.10 354 418 3.9E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 Pfam PF00196 Bacterial regulatory proteins, luxR family 362 416 2.8E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 SUPERFAMILY SSF46894 349 418 1.39E-16 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 Gene3D G3DSA:1.25.40.10 116 155 2.7E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 Gene3D G3DSA:1.25.40.10 227 343 2.7E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 363 377 1.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 393 405 1.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 377 393 1.5E-8 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS39545 8103602381e954d796dd839e6a6a5e4a 424 SMART SM00421 360 417 2.6E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12470 fd2012db3ed7e9bb32392858c09d38a0 218 SMART SM00756 25 170 3.4E-45 T 17-03-2017 IPR012932 Vitamin K epoxide reductase Reactome: R-HSA-6806664 SHXM_RS12470 fd2012db3ed7e9bb32392858c09d38a0 218 Pfam PF07884 Vitamin K epoxide reductase family 31 166 3.6E-26 T 17-03-2017 IPR012932 Vitamin K epoxide reductase Reactome: R-HSA-6806664 SHXM_RS49285 b3e3e28b8b6659f122cc1f9c05926eb6 155 Pfam PF13551 Winged helix-turn helix 16 69 4.0E-9 T 17-03-2017 SHXM_RS49285 b3e3e28b8b6659f122cc1f9c05926eb6 155 Pfam PF13592 Winged helix-turn helix 88 146 1.0E-17 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS49285 b3e3e28b8b6659f122cc1f9c05926eb6 155 SUPERFAMILY SSF46689 5 118 4.48E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47940 d6f7074e6c346853b94dd2c80b8e1f9c 220 Pfam PF00857 Isochorismatase family 21 207 1.0E-34 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS47940 d6f7074e6c346853b94dd2c80b8e1f9c 220 SUPERFAMILY SSF52499 11 214 1.57E-45 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS47940 d6f7074e6c346853b94dd2c80b8e1f9c 220 Gene3D G3DSA:3.40.50.850 9 217 2.2E-49 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS01765 c9a48c2edb6ccfa7a75bf18c6fe5f0d2 337 Gene3D G3DSA:3.40.718.10 6 329 1.1E-125 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS01765 c9a48c2edb6ccfa7a75bf18c6fe5f0d2 337 Hamap MF_00536 4-hydroxythreonine-4-phosphate dehydrogenase [pdxA]. 4 329 34.506 T 17-03-2017 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS01765 c9a48c2edb6ccfa7a75bf18c6fe5f0d2 337 TIGRFAM TIGR00557 pdxA: 4-hydroxythreonine-4-phosphate dehydrogenase PdxA 8 329 1.4E-108 T 17-03-2017 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS01765 c9a48c2edb6ccfa7a75bf18c6fe5f0d2 337 Pfam PF04166 Pyridoxal phosphate biosynthetic protein PdxA 35 325 1.7E-101 T 17-03-2017 IPR005255 4-hydroxythreonine-4-phosphate dehydrogenase PdxA GO:0008615|GO:0050570|GO:0051287|GO:0055114 KEGG: 00630+1.1.1.26|KEGG: 00750+1.1.1.262|MetaCyc: PWY-7294|MetaCyc: PWY-7295 SHXM_RS01765 c9a48c2edb6ccfa7a75bf18c6fe5f0d2 337 SUPERFAMILY SSF53659 6 329 1.69E-105 T 17-03-2017 SHXM_RS08510 25c4513af1a1cbdfc9fd6405eae20b52 411 Gene3D G3DSA:3.30.70.1230 20 191 3.2E-5 T 17-03-2017 IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase GO:0009190|GO:0016849|GO:0035556 SHXM_RS08510 25c4513af1a1cbdfc9fd6405eae20b52 411 SUPERFAMILY SSF55073 18 195 1.16E-10 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS22685 c5105cf50d520c847c4eca0088d675b7 177 Gene3D G3DSA:3.40.630.30 6 161 1.9E-19 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS22685 c5105cf50d520c847c4eca0088d675b7 177 SUPERFAMILY SSF55729 12 163 2.62E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS22685 c5105cf50d520c847c4eca0088d675b7 177 Pfam PF13508 Acetyltransferase (GNAT) domain 61 156 9.3E-8 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 Gene3D G3DSA:3.40.190.10 198 276 3.9E-20 T 17-03-2017 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 28 39 5.9E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 49 60 5.9E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 49 5.9E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 Pfam PF03466 LysR substrate binding domain 98 303 2.6E-33 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 Gene3D G3DSA:1.10.10.10 11 96 4.6E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 Gene3D G3DSA:3.40.190.10 99 197 5.6E-19 T 17-03-2017 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 13 71 4.8E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 SUPERFAMILY SSF53850 100 304 1.49E-29 T 17-03-2017 SHXM_RS03765 2e8b0bec348790accce332550827a37f 317 SUPERFAMILY SSF46785 7 121 1.24E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37760 f0831e6411c10d1acf92e6985fde710e 283 Pfam PF12697 Alpha/beta hydrolase family 35 261 6.5E-11 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS37760 f0831e6411c10d1acf92e6985fde710e 283 SUPERFAMILY SSF53474 22 271 2.62E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37760 f0831e6411c10d1acf92e6985fde710e 283 Gene3D G3DSA:3.40.50.1820 34 273 8.1E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20285 9dc3588751413c261e9397a662a88faa 153 SMART SM00422 29 98 7.5E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS20285 9dc3588751413c261e9397a662a88faa 153 Pfam PF13411 MerR HTH family regulatory protein 29 90 5.6E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS20285 9dc3588751413c261e9397a662a88faa 153 SUPERFAMILY SSF46955 29 142 1.1E-28 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS20285 9dc3588751413c261e9397a662a88faa 153 Gene3D G3DSA:1.10.1660.10 29 144 4.4E-31 T 17-03-2017 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 SUPERFAMILY SSF54665 5 143 2.75E-35 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 SMART SM01008 24 133 2.2E-32 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Pfam PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase 155 679 5.5E-110 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Pfam PF01315 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain 25 132 9.5E-23 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.30.365.10 441 605 9.1E-23 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.30.365.10 168 272 1.9E-30 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.30.365.10 348 437 3.0E-52 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.30.365.10 606 734 3.0E-52 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.90.1170.50 3 120 2.4E-34 T 17-03-2017 IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.30.365.10 275 328 7.7E-9 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 Gene3D G3DSA:3.30.365.10 121 167 7.7E-9 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS47995 5f14596b18c9dc648a99232d751bf744 735 SUPERFAMILY SSF56003 125 734 6.15E-152 T 17-03-2017 IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding GO:0016491|GO:0055114 SHXM_RS19215 22098986a7f8a133dcc8cb52d4a87393 84 SUPERFAMILY SSF46689 14 59 6.72E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19215 22098986a7f8a133dcc8cb52d4a87393 84 Gene3D G3DSA:1.10.10.60 21 57 9.2E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30320 76656d5f0683fbeb400c96b1a5d82039 287 ProDom PD040376 SCO3349 RV0495C/MT0515 ML2435 MB0506C CGL0407 40 275 2.0E-118 T 17-03-2017 SHXM_RS07775 a927e10c837bfa91bbcab2cd32a56832 292 SUPERFAMILY SSF161098 18 292 2.06E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07775 a927e10c837bfa91bbcab2cd32a56832 292 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 267 2.8E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07775 a927e10c837bfa91bbcab2cd32a56832 292 Gene3D G3DSA:1.10.3720.10 17 278 1.0E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS28425 da2850f8d4d3a60f0729c0ca366b1b09 345 Gene3D G3DSA:3.30.200.20 17 110 1.8E-15 T 17-03-2017 SHXM_RS28425 da2850f8d4d3a60f0729c0ca366b1b09 345 Pfam PF01636 Phosphotransferase enzyme family 34 280 5.6E-26 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS28425 da2850f8d4d3a60f0729c0ca366b1b09 345 Gene3D G3DSA:3.90.1200.10 119 340 1.5E-19 T 17-03-2017 SHXM_RS28425 da2850f8d4d3a60f0729c0ca366b1b09 345 SUPERFAMILY SSF56112 16 332 1.15E-38 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS23510 c5893235666777388ef756e933039825 455 Pfam PF02913 FAD linked oxidases, C-terminal domain 219 454 5.1E-68 T 17-03-2017 IPR004113 FAD-linked oxidase, C-terminal GO:0003824|GO:0050660 SHXM_RS23510 c5893235666777388ef756e933039825 455 Gene3D G3DSA:3.30.43.10 2 95 2.7E-25 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS23510 c5893235666777388ef756e933039825 455 Gene3D G3DSA:1.10.45.10 415 454 1.7E-13 T 17-03-2017 IPR016171 Vanillyl-alcohol oxidase, C-terminal subdomain 2 SHXM_RS23510 c5893235666777388ef756e933039825 455 Gene3D G3DSA:3.30.465.10 96 216 2.5E-42 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS23510 c5893235666777388ef756e933039825 455 SUPERFAMILY SSF56176 2 216 7.94E-68 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS23510 c5893235666777388ef756e933039825 455 SUPERFAMILY SSF55103 191 454 4.09E-62 T 17-03-2017 IPR016164 FAD-linked oxidase-like, C-terminal GO:0003824|GO:0050660 SHXM_RS23510 c5893235666777388ef756e933039825 455 Pfam PF01565 FAD binding domain 40 178 2.5E-38 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 SUPERFAMILY SSF50621 1 130 1.64E-46 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 SMART SM01005 2 130 9.5E-65 T 17-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 Pfam PF00842 Alanine racemase, C-terminal domain 2 128 1.8E-40 T 17-03-2017 IPR011079 Alanine racemase, C-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 PRINTS PR00992 Alanine racemase signature 18 33 2.7E-22 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 PRINTS PR00992 Alanine racemase signature 56 73 2.7E-22 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 PRINTS PR00992 Alanine racemase signature 111 124 2.7E-22 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 PRINTS PR00992 Alanine racemase signature 35 50 2.7E-22 T 17-03-2017 IPR000821 Alanine racemase GO:0006522|GO:0008784 KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS50895 ae67ac191d4e9ca689dcb7455bba3a29 134 Gene3D G3DSA:2.40.37.10 1 131 1.1E-51 T 17-03-2017 IPR009006 Alanine racemase/group IV decarboxylase, C-terminal GO:0003824 SHXM_RS10450 65926e724ea1e8b7ce347bce3625e2dc 150 SUPERFAMILY SSF54637 1 148 4.62E-20 T 17-03-2017 IPR029069 HotDog domain SHXM_RS10450 65926e724ea1e8b7ce347bce3625e2dc 150 Pfam PF14539 Domain of unknown function (DUF4442) 11 145 8.0E-26 T 17-03-2017 IPR027961 Protein of unknown function DUF4442 SHXM_RS10450 65926e724ea1e8b7ce347bce3625e2dc 150 Gene3D G3DSA:3.10.129.10 10 149 1.2E-38 T 17-03-2017 IPR029069 HotDog domain SHXM_RS04440 e6d60cc2261994a8cde6cf5a8262e1b6 271 SUPERFAMILY SSF53335 23 251 2.79E-22 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04440 e6d60cc2261994a8cde6cf5a8262e1b6 271 Pfam PF13489 Methyltransferase domain 95 204 4.2E-10 T 17-03-2017 SHXM_RS04440 e6d60cc2261994a8cde6cf5a8262e1b6 271 Gene3D G3DSA:3.40.50.150 21 249 1.9E-19 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22370 122a7e1b7487bffa4c7c6ab64d97522e 276 Gene3D G3DSA:3.20.20.150 10 273 2.6E-73 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS22370 122a7e1b7487bffa4c7c6ab64d97522e 276 SUPERFAMILY SSF51658 4 273 4.45E-60 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS22370 122a7e1b7487bffa4c7c6ab64d97522e 276 Pfam PF01261 Xylose isomerase-like TIM barrel 27 221 2.1E-32 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS35565 bbf6833806fbfca4d20ea1c8cbbf09eb 261 SUPERFAMILY SSF53335 24 243 1.58E-40 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS35565 bbf6833806fbfca4d20ea1c8cbbf09eb 261 Pfam PF13847 Methyltransferase domain 44 158 2.5E-22 T 17-03-2017 IPR025714 Methyltransferase domain SHXM_RS35565 bbf6833806fbfca4d20ea1c8cbbf09eb 261 Gene3D G3DSA:3.40.50.150 18 207 1.1E-40 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01950 2b88fe243b3a989aef067367c65ea7b3 183 SUPERFAMILY SSF55729 55 167 6.73E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS01950 2b88fe243b3a989aef067367c65ea7b3 183 Pfam PF00583 Acetyltransferase (GNAT) family 77 149 3.9E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS01950 2b88fe243b3a989aef067367c65ea7b3 183 Gene3D G3DSA:3.40.630.30 30 171 2.4E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS20185 223780aab53f7951f7e22a1499c22f99 286 PIRSF PIRSF030802 1 244 6.1E-17 T 17-03-2017 IPR024197 Uncharacterised conserved protein UCP030802 SHXM_RS20185 223780aab53f7951f7e22a1499c22f99 286 SUPERFAMILY SSF56784 41 227 2.08E-13 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS20185 223780aab53f7951f7e22a1499c22f99 286 SUPERFAMILY SSF56784 3 14 2.08E-13 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS20185 223780aab53f7951f7e22a1499c22f99 286 Gene3D G3DSA:3.40.50.1000 4 105 6.2E-9 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS20185 223780aab53f7951f7e22a1499c22f99 286 Gene3D G3DSA:3.40.50.1000 181 226 6.2E-9 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS33710 4d6398bd6edceb9852edaeee99f5b7d7 393 SUPERFAMILY SSF52540 2 118 1.09E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33710 4d6398bd6edceb9852edaeee99f5b7d7 393 Pfam PF13635 Domain of unknown function (DUF4143) 179 339 1.1E-23 T 17-03-2017 IPR025420 Domain of unknown function DUF4143 SHXM_RS33710 4d6398bd6edceb9852edaeee99f5b7d7 393 Pfam PF13173 AAA domain 1 117 8.8E-19 T 17-03-2017 SHXM_RS24010 84abbc30a537226f461dc8a3090de3ce 187 Gene3D G3DSA:1.10.357.10 60 181 2.4E-17 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS24010 84abbc30a537226f461dc8a3090de3ce 187 SUPERFAMILY SSF48498 70 181 3.46E-20 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS24010 84abbc30a537226f461dc8a3090de3ce 187 Gene3D G3DSA:1.10.10.60 2 53 1.2E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS24010 84abbc30a537226f461dc8a3090de3ce 187 ProSitePatterns PS01081 TetR-type HTH domain signature. 13 43 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS24010 84abbc30a537226f461dc8a3090de3ce 187 Pfam PF00440 Bacterial regulatory proteins, tetR family 3 47 1.8E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS24010 84abbc30a537226f461dc8a3090de3ce 187 SUPERFAMILY SSF46689 3 63 1.59E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 281 297 1.5E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 266 281 1.5E-5 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 Gene3D G3DSA:1.10.10.60 251 299 1.9E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 Pfam PF12833 Helix-turn-helix domain 223 299 3.1E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 Gene3D G3DSA:1.10.10.60 197 250 9.8E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 Gene3D G3DSA:2.60.120.10 22 106 1.1E-10 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 SMART SM00342 214 297 3.5E-26 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 SUPERFAMILY SSF46689 250 300 1.34E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 SUPERFAMILY SSF51182 44 131 9.79E-13 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 SUPERFAMILY SSF46689 198 248 9.86E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50470 1b91ad9db924cbf2fd4a2a1b6c45b001 318 Pfam PF02311 AraC-like ligand binding domain 44 92 7.2E-9 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 26 444 1.8E-76 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 PRINTS PR01036 Tetracycline resistance protein TetB signature 118 138 6.0E-9 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 PRINTS PR01036 Tetracycline resistance protein TetB signature 148 172 6.0E-9 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 PRINTS PR01036 Tetracycline resistance protein TetB signature 413 432 6.0E-9 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 PRINTS PR01036 Tetracycline resistance protein TetB signature 314 338 6.0E-9 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 PRINTS PR01036 Tetracycline resistance protein TetB signature 28 52 6.0E-9 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 Gene3D G3DSA:1.20.1250.20 23 204 2.1E-32 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 Gene3D G3DSA:1.20.1250.20 276 430 3.6E-21 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 Gene3D G3DSA:1.20.1250.20 469 499 3.6E-21 T 17-03-2017 SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 SUPERFAMILY SSF103473 9 205 9.02E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 SUPERFAMILY SSF103473 471 495 9.02E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 SUPERFAMILY SSF103473 259 432 9.02E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04190 84d63bcc280242ada17060f68aceb64b 522 Pfam PF07690 Major Facilitator Superfamily 29 422 1.3E-52 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS46930 95b99bf162870e503ea4a7e4892e7261 142 Pfam PF03995 Peptidase inhibitor family I36 52 116 6.0E-6 T 17-03-2017 SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 SUPERFAMILY SSF56801 15 515 4.19E-112 T 17-03-2017 SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 Pfam PF00501 AMP-binding enzyme 21 416 6.5E-66 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 Gene3D G3DSA:3.40.50.980 16 186 1.3E-28 T 17-03-2017 SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 Gene3D G3DSA:3.30.300.30 411 513 8.0E-22 T 17-03-2017 SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 Pfam PF13193 AMP-binding enzyme C-terminal domain 425 499 3.6E-11 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 ProSitePatterns PS00455 Putative AMP-binding domain signature. 180 191 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 Gene3D G3DSA:3.40.50.980 187 340 1.8E-26 T 17-03-2017 SHXM_RS31630 1b727e258898ee73b602c3b297122dac 559 Gene3D G3DSA:2.30.38.10 359 410 5.6E-12 T 17-03-2017 SHXM_RS08455 3cf18a2f162705e8526e7b72ba998a04 230 TIGRFAM TIGR00101 ureG: urease accessory protein UreG 30 222 8.3E-84 T 17-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 SHXM_RS08455 3cf18a2f162705e8526e7b72ba998a04 230 Hamap MF_01389 Urease accessory protein UreG [ureG]. 28 226 43.901 T 17-03-2017 IPR004400 Urease accessory protein UreG GO:0003924|GO:0006807|GO:0016151 SHXM_RS08455 3cf18a2f162705e8526e7b72ba998a04 230 Gene3D G3DSA:3.40.50.300 28 198 9.9E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08455 3cf18a2f162705e8526e7b72ba998a04 230 SUPERFAMILY SSF52540 24 227 3.06E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08455 3cf18a2f162705e8526e7b72ba998a04 230 PIRSF PIRSF005624 14 230 2.2E-47 T 17-03-2017 SHXM_RS08455 3cf18a2f162705e8526e7b72ba998a04 230 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain 32 201 1.8E-35 T 17-03-2017 IPR003495 CobW/HypB/UreG, nucleotide-binding domain SHXM_RS28350 9fe25dede634ab31b52bbc4252e89cdb 574 Gene3D G3DSA:3.40.605.10 99 332 2.3E-27 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS28350 9fe25dede634ab31b52bbc4252e89cdb 574 Pfam PF00171 Aldehyde dehydrogenase family 99 527 1.0E-28 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS28350 9fe25dede634ab31b52bbc4252e89cdb 574 Gene3D G3DSA:3.40.309.10 333 534 3.4E-26 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS28350 9fe25dede634ab31b52bbc4252e89cdb 574 SUPERFAMILY SSF53720 79 549 1.05E-54 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS28350 9fe25dede634ab31b52bbc4252e89cdb 574 TIGRFAM TIGR02288 PaaN_2: phenylacetic acid degradation protein paaN 8 573 3.7E-280 T 17-03-2017 IPR011975 Phenylacetic acid degradation protein PaaN2 SHXM_RS12705 0f2dadabf622e23ccfc070b7fc79b028 351 SUPERFAMILY SSF56322 48 338 2.22E-87 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS12705 0f2dadabf622e23ccfc070b7fc79b028 351 Gene3D G3DSA:3.60.120.10 66 339 4.2E-96 T 17-03-2017 IPR005801 ADC synthase GO:0009058 SHXM_RS12705 0f2dadabf622e23ccfc070b7fc79b028 351 PRINTS PR00095 Anthranilate synthase component I signature 284 298 7.3E-11 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS12705 0f2dadabf622e23ccfc070b7fc79b028 351 PRINTS PR00095 Anthranilate synthase component I signature 188 201 7.3E-11 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS12705 0f2dadabf622e23ccfc070b7fc79b028 351 PRINTS PR00095 Anthranilate synthase component I signature 268 282 7.3E-11 T 17-03-2017 IPR019999 Anthranilate synthase component I-like GO:0009058 KEGG: 00400+4.1.3.27|MetaCyc: PWY-5958|MetaCyc: PWY-6660|MetaCyc: PWY-6661 SHXM_RS12705 0f2dadabf622e23ccfc070b7fc79b028 351 Pfam PF00425 chorismate binding enzyme 79 331 2.6E-69 T 17-03-2017 IPR015890 Chorismate-utilising enzyme, C-terminal SHXM_RS38435 89e8be698a36053ee948d45761955b9c 350 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 265 4.3E-44 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS38435 89e8be698a36053ee948d45761955b9c 350 SUPERFAMILY SSF51735 1 121 2.54E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38435 89e8be698a36053ee948d45761955b9c 350 SUPERFAMILY SSF51735 158 343 2.54E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38435 89e8be698a36053ee948d45761955b9c 350 Gene3D G3DSA:3.40.50.720 163 340 4.1E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38435 89e8be698a36053ee948d45761955b9c 350 Gene3D G3DSA:3.40.50.720 1 130 4.1E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS06820 48232eaeb1505ce3a5c12e0858303e59 306 Pfam PF03547 Membrane transport protein 158 298 3.9E-12 T 17-03-2017 IPR004776 Membrane transport protein GO:0016021|GO:0055085 SHXM_RS06820 48232eaeb1505ce3a5c12e0858303e59 306 Pfam PF03547 Membrane transport protein 13 133 6.1E-9 T 17-03-2017 IPR004776 Membrane transport protein GO:0016021|GO:0055085 SHXM_RS10505 776e90a3d9aebd023f7aeabc8588134b 302 Pfam PF01425 Amidase 15 274 4.7E-28 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS10505 776e90a3d9aebd023f7aeabc8588134b 302 SUPERFAMILY SSF75304 14 292 1.96E-38 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS10505 776e90a3d9aebd023f7aeabc8588134b 302 Gene3D G3DSA:3.90.1300.10 16 297 2.7E-48 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS35220 643c4b35b5e363e4747563be1354b4ba 485 Pfam PF00953 Glycosyl transferase family 4 87 246 1.5E-35 T 17-03-2017 IPR000715 Glycosyl transferase, family 4 GO:0008963|GO:0016021 KEGG: 00550+2.7.8.13|MetaCyc: PWY-5265|MetaCyc: PWY-6470|MetaCyc: PWY-6471|Reactome: R-HSA-446193|Reactome: R-HSA-4549356 SHXM_RS40170 b7aa4091021fa13061801e9c0d4b9fb2 316 SUPERFAMILY SSF53335 25 206 1.9E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40170 b7aa4091021fa13061801e9c0d4b9fb2 316 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 26 233 7.8E-28 T 17-03-2017 SHXM_RS40170 b7aa4091021fa13061801e9c0d4b9fb2 316 Gene3D G3DSA:3.40.50.150 31 239 5.3E-43 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 2.0E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 187 2.0E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 2.0E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 189 206 2.0E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 2.0E-23 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 168 187 9.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 9.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 Pfam PF00106 short chain dehydrogenase 10 207 2.4E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 SUPERFAMILY SSF51735 10 245 9.05E-56 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39405 fcecdae01e9ac9b20a9f1db955c5c625 245 Gene3D G3DSA:3.40.50.720 8 243 5.5E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25685 a4c5b1ff26608a425910b81426b06d13 488 Pfam PF00860 Permease family 40 440 1.3E-31 T 17-03-2017 IPR006043 Xanthine/uracil/vitamin C permease GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS50945 b816356458b30e8625024bee9c592a10 190 SUPERFAMILY SSF55729 33 165 3.14E-13 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS50945 b816356458b30e8625024bee9c592a10 190 Pfam PF00583 Acetyltransferase (GNAT) family 71 159 2.1E-7 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS50945 b816356458b30e8625024bee9c592a10 190 Gene3D G3DSA:3.40.630.30 53 166 1.3E-13 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS01495 971c2be1d65714e53a453a9611713e7d 324 Gene3D G3DSA:1.10.3720.10 88 312 1.9E-41 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01495 971c2be1d65714e53a453a9611713e7d 324 SUPERFAMILY SSF161098 78 306 9.38E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01495 971c2be1d65714e53a453a9611713e7d 324 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 111 304 1.0E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11120 37b120aec987ae27b4f10b67cf628ac8 127 SUPERFAMILY SSF56281 8 125 1.68E-26 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS11120 37b120aec987ae27b4f10b67cf628ac8 127 Gene3D G3DSA:3.60.15.10 12 123 2.3E-28 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS11120 37b120aec987ae27b4f10b67cf628ac8 127 Pfam PF00753 Metallo-beta-lactamase superfamily 16 124 2.9E-5 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS46460 ecbf1f77aae1f2a240de9752828d6f72 342 SUPERFAMILY SSF50331 211 336 2.41E-9 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS46460 ecbf1f77aae1f2a240de9752828d6f72 342 Gene3D G3DSA:3.40.50.300 2 214 4.5E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46460 ecbf1f77aae1f2a240de9752828d6f72 342 SUPERFAMILY SSF52540 4 215 3.17E-81 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46460 ecbf1f77aae1f2a240de9752828d6f72 342 Pfam PF00005 ABC transporter 2 136 1.3E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46460 ecbf1f77aae1f2a240de9752828d6f72 342 SMART SM00382 3 186 2.3E-19 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS46460 ecbf1f77aae1f2a240de9752828d6f72 342 Pfam PF08402 TOBE domain 255 337 2.1E-8 T 17-03-2017 IPR013611 Transport-associated OB, type 2 GO:0005215|GO:0005524|GO:0006810|GO:0016820|GO:0043190 SHXM_RS19050 a6d99e25ae0f7756a66db4c0f024ea53 299 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 217 7.3E-14 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS19050 a6d99e25ae0f7756a66db4c0f024ea53 299 SUPERFAMILY SSF51735 4 262 1.03E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19050 a6d99e25ae0f7756a66db4c0f024ea53 299 Pfam PF08338 Domain of unknown function (DUF1731) 251 296 2.8E-17 T 17-03-2017 IPR013549 Domain of unknown function DUF1731 SHXM_RS19050 a6d99e25ae0f7756a66db4c0f024ea53 299 Gene3D G3DSA:3.40.50.720 4 239 6.3E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19050 a6d99e25ae0f7756a66db4c0f024ea53 299 TIGRFAM TIGR01777 yfcH: TIGR01777 family protein 6 294 6.6E-102 T 17-03-2017 IPR010099 Epimerase family protein SDR39U1 SHXM_RS41955 dd16b51c803536f190cf451b928e6113 209 Pfam PF03713 Domain of unknown function (DUF305) 65 193 3.8E-19 T 17-03-2017 IPR005183 Domain of unknown function DUF305 SHXM_RS41955 dd16b51c803536f190cf451b928e6113 209 Gene3D G3DSA:1.20.1260.10 59 193 9.6E-25 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 Gene3D G3DSA:3.40.50.980 23 193 1.8E-25 T 17-03-2017 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 SUPERFAMILY SSF56801 18 295 1.83E-107 T 17-03-2017 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 SUPERFAMILY SSF56801 349 608 1.83E-107 T 17-03-2017 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 Pfam PF00501 AMP-binding enzyme 26 478 7.7E-87 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 Gene3D G3DSA:3.40.50.980 346 408 8.6E-28 T 17-03-2017 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 Gene3D G3DSA:3.40.50.980 194 290 8.6E-28 T 17-03-2017 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 Gene3D G3DSA:3.30.300.30 476 598 7.1E-6 T 17-03-2017 SHXM_RS43620 f3e57886645d4101d913388dd2088d44 610 Gene3D G3DSA:2.30.38.10 409 469 1.7E-19 T 17-03-2017 SHXM_RS31940 d4b399ba9cd094cbeac3f91e7d243562 428 SUPERFAMILY SSF53850 38 338 6.34E-29 T 17-03-2017 SHXM_RS31940 d4b399ba9cd094cbeac3f91e7d243562 428 Pfam PF13416 Bacterial extracellular solute-binding protein 56 229 7.9E-7 T 17-03-2017 SHXM_RS31940 d4b399ba9cd094cbeac3f91e7d243562 428 Gene3D G3DSA:3.40.190.10 40 157 8.2E-13 T 17-03-2017 SHXM_RS31940 d4b399ba9cd094cbeac3f91e7d243562 428 Gene3D G3DSA:3.40.190.10 169 330 1.7E-6 T 17-03-2017 SHXM_RS18885 755770a195f1d4ea2236a6c4520e4334 206 Pfam PF00510 Cytochrome c oxidase subunit III 26 204 5.4E-24 T 17-03-2017 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18885 755770a195f1d4ea2236a6c4520e4334 206 SUPERFAMILY SSF81452 11 204 3.14E-54 T 17-03-2017 IPR000298 Cytochrome c oxidase subunit III domain GO:0015002|GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS18885 755770a195f1d4ea2236a6c4520e4334 206 Gene3D G3DSA:1.20.120.80 25 205 1.6E-53 T 17-03-2017 IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle GO:0004129|GO:0016020|GO:0022904 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS21155 945ed0e79ae0b75a58ec546623862489 232 Pfam PF01965 DJ-1/PfpI family 5 161 1.0E-27 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS21155 945ed0e79ae0b75a58ec546623862489 232 SUPERFAMILY SSF52317 1 185 5.35E-46 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS21155 945ed0e79ae0b75a58ec546623862489 232 Gene3D G3DSA:3.40.50.880 1 205 5.4E-58 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS27815 43e0e76895074f9afcc16bac1db74e8b 428 SUPERFAMILY SSF56300 156 415 1.82E-34 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS27815 43e0e76895074f9afcc16bac1db74e8b 428 Gene3D G3DSA:3.60.21.10 152 425 9.0E-34 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS27815 43e0e76895074f9afcc16bac1db74e8b 428 PRINTS PR00114 Serine/threonine phosphatase family signature 158 185 2.3E-5 T 17-03-2017 IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase GO:0016787 KEGG: 04660+3.1.3.16 SHXM_RS27815 43e0e76895074f9afcc16bac1db74e8b 428 PRINTS PR00114 Serine/threonine phosphatase family signature 195 222 2.3E-5 T 17-03-2017 IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase GO:0016787 KEGG: 04660+3.1.3.16 SHXM_RS27815 43e0e76895074f9afcc16bac1db74e8b 428 Pfam PF00149 Calcineurin-like phosphoesterase 158 375 1.7E-8 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 Pfam PF00067 Cytochrome P450 288 377 5.1E-17 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 Gene3D G3DSA:1.10.630.10 7 409 2.7E-116 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 SUPERFAMILY SSF48264 6 409 1.22E-83 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 148 164 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 165 180 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 361 372 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 352 361 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 207 229 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 302 329 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 285 296 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 330 345 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19865 21a4e0f84daed4250768aaa53db7d56d 410 PRINTS PR00359 B-class P450 signature 102 113 2.1E-46 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 SUPERFAMILY SSF53901 276 397 4.45E-38 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 11 397 1.5E-129 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 Pfam PF02803 Thiolase, C-terminal domain 276 397 2.3E-36 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 SUPERFAMILY SSF53901 7 273 9.98E-58 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 Gene3D G3DSA:3.40.47.10 152 191 3.7E-49 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 Gene3D G3DSA:3.40.47.10 280 398 3.7E-49 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 PIRSF PIRSF000429 3 400 5.6E-121 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 ProSitePatterns PS00737 Thiolases signature 2. 344 360 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 Pfam PF00108 Thiolase, N-terminal domain 8 266 3.0E-56 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 Gene3D G3DSA:3.40.47.10 192 278 4.9E-52 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS38230 37f21193ef70e223cd6cf57ace94d4b2 405 Gene3D G3DSA:3.40.47.10 7 131 4.9E-52 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 Pfam PF01564 Spermine/spermidine synthase 280 454 2.7E-26 T 17-03-2017 SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 SUPERFAMILY SSF53335 238 459 7.77E-45 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 Gene3D G3DSA:3.40.50.150 291 511 8.7E-54 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 SUPERFAMILY SSF103473 8 212 3.4E-10 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 ProSitePatterns PS01330 Polyamine biosynthesis (PABS) domain signature. 313 326 - T 17-03-2017 IPR030373 Polyamine biosynthesis domain, conserved site KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 Hamap MF_00198 Polyamine aminopropyltransferase [speE]. 206 520 19.894 T 17-03-2017 IPR001045 Spermidine/spermine synthases GO:0003824 KEGG: 00270+2.5.1.16|KEGG: 00330+2.5.1.16|KEGG: 00410+2.5.1.16|KEGG: 00480+2.5.1.16|Reactome: R-HSA-351202 SHXM_RS29220 e50ea9f6ae20b29c1b92ba1c7d4afb89 531 Gene3D G3DSA:1.20.1250.20 20 209 2.0E-6 T 17-03-2017 SHXM_RS07345 91d0073018c20ffc4ab73fef8b5e0f17 332 TIGRFAM TIGR00750 lao: LAO/AO transport system ATPase 17 323 8.8E-113 T 17-03-2017 IPR005129 SIMIBI class G3E GTPase, ArgK/MeaB GO:0003924|GO:0005525 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS07345 91d0073018c20ffc4ab73fef8b5e0f17 332 Gene3D G3DSA:3.40.50.300 56 258 3.9E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07345 91d0073018c20ffc4ab73fef8b5e0f17 332 SUPERFAMILY SSF52540 4 326 3.73E-95 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07345 91d0073018c20ffc4ab73fef8b5e0f17 332 Gene3D G3DSA:1.20.5.170 3 55 2.2E-22 T 17-03-2017 SHXM_RS07345 91d0073018c20ffc4ab73fef8b5e0f17 332 Gene3D G3DSA:1.10.287.130 264 312 6.6E-4 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS07345 91d0073018c20ffc4ab73fef8b5e0f17 332 Pfam PF03308 ArgK protein 22 294 6.1E-112 T 17-03-2017 SHXM_RS14495 df94cfa0c0557e0f19bdb65f6c68039e 341 SUPERFAMILY SSF51556 3 337 4.22E-76 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS14495 df94cfa0c0557e0f19bdb65f6c68039e 341 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 5 335 1.6E-80 T 17-03-2017 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533|Reactome: R-HSA-2142691|Reactome: R-HSA-5423646 SHXM_RS14495 df94cfa0c0557e0f19bdb65f6c68039e 341 Gene3D G3DSA:3.20.20.140 3 336 3.2E-93 T 17-03-2017 SHXM_RS06705 025f4d28a04704ada1d80bd0af235853 418 Pfam PF12876 Sugar-binding cellulase-like 13 116 5.3E-12 T 17-03-2017 IPR024778 Putative cellulase SHXM_RS06705 025f4d28a04704ada1d80bd0af235853 418 SUPERFAMILY SSF51445 14 241 2.92E-11 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06705 025f4d28a04704ada1d80bd0af235853 418 SUPERFAMILY SSF51445 302 356 2.92E-11 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06705 025f4d28a04704ada1d80bd0af235853 418 Gene3D G3DSA:3.20.20.80 27 240 1.8E-10 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS06705 025f4d28a04704ada1d80bd0af235853 418 Gene3D G3DSA:3.20.20.80 312 355 1.8E-10 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS48715 d40cd5ddfc85fef3d08e6f99ac3330f9 151 Pfam PF00583 Acetyltransferase (GNAT) family 52 130 1.5E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS48715 d40cd5ddfc85fef3d08e6f99ac3330f9 151 Gene3D G3DSA:3.40.630.30 25 149 5.7E-27 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS48715 d40cd5ddfc85fef3d08e6f99ac3330f9 151 SUPERFAMILY SSF55729 7 151 4.29E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38105 39a14197f60ef1ad485696cb0b50b737 189 SUPERFAMILY SSF52980 27 165 5.9E-14 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS38105 39a14197f60ef1ad485696cb0b50b737 189 Gene3D G3DSA:3.90.1570.10 25 157 1.5E-13 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS38105 39a14197f60ef1ad485696cb0b50b737 189 Pfam PF05685 Putative restriction endonuclease 29 184 5.2E-18 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS45070 01ff1848b73404bc6874626fc7249644 166 Pfam PF00583 Acetyltransferase (GNAT) family 62 140 8.8E-11 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS45070 01ff1848b73404bc6874626fc7249644 166 Gene3D G3DSA:3.40.630.30 4 163 1.0E-32 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS45070 01ff1848b73404bc6874626fc7249644 166 SUPERFAMILY SSF55729 3 166 1.2E-30 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 Pfam PF09363 XFP C-terminal domain 600 802 1.3E-82 T 17-03-2017 IPR018969 Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, C-terminal GO:0005975|GO:0016832 SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 Pfam PF09364 XFP N-terminal domain 24 398 9.8E-177 T 17-03-2017 IPR018970 Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, N-terminal SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 Pfam PF03894 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase 413 588 8.2E-85 T 17-03-2017 IPR005593 Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase GO:0005975|GO:0016832 SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 ProSitePatterns PS60003 Phosphoketolase signature 2. 171 189 - T 17-03-2017 IPR019789 Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, thiamine diphosphate binding site GO:0005975|GO:0016832 SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 SUPERFAMILY SSF52518 21 383 3.63E-72 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 Gene3D G3DSA:3.40.50.970 67 271 1.4E-19 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 PIRSF PIRSF017245 11 804 0.0 T 17-03-2017 IPR005593 Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase GO:0005975|GO:0016832 SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 SUPERFAMILY SSF52518 390 602 4.59E-21 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 Hamap MF_01403 Probable phosphoketolase. 19 804 40.376 T 17-03-2017 IPR023962 Probable phosphoketolase SHXM_RS07980 1ce3cdcad197514e46e46de53477442d 804 ProSitePatterns PS60002 Phosphoketolase signature 1. 158 164 - T 17-03-2017 IPR019790 Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase, conserved site GO:0005975|GO:0016832 SHXM_RS12945 65dd0412153e1ba042a5d4d851c199d4 326 SUPERFAMILY SSF53590 6 314 1.14E-91 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS12945 65dd0412153e1ba042a5d4d851c199d4 326 Gene3D G3DSA:3.90.245.10 5 314 7.8E-100 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS12945 65dd0412153e1ba042a5d4d851c199d4 326 Pfam PF01156 Inosine-uridine preferring nucleoside hydrolase 7 306 1.5E-69 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS12945 65dd0412153e1ba042a5d4d851c199d4 326 ProSitePatterns PS01247 Inosine-uridine preferring nucleoside hydrolase family signature. 11 21 - T 17-03-2017 IPR015910 Inosine/uridine-preferring nucleoside hydrolase, conserved site GO:0016799 SHXM_RS30900 10210c155c325613227c43301824f0cc 360 Gene3D G3DSA:3.40.50.970 35 262 9.5E-86 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS30900 10210c155c325613227c43301824f0cc 360 Pfam PF02775 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain 72 219 2.4E-29 T 17-03-2017 IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-binding GO:0003824|GO:0030976 SHXM_RS30900 10210c155c325613227c43301824f0cc 360 SUPERFAMILY SSF52518 28 359 3.22E-85 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 Pfam PF08386 TAP-like protein 392 483 2.7E-26 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 SUPERFAMILY SSF53474 83 139 6.56E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 SUPERFAMILY SSF53474 373 461 6.56E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 SUPERFAMILY SSF53474 185 299 6.56E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 Gene3D G3DSA:3.40.50.1820 52 138 3.0E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 Gene3D G3DSA:3.40.50.1820 183 306 3.0E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20150 6db0b36d8e9648254e81e3c92d375fa6 489 Gene3D G3DSA:3.40.50.1820 351 471 3.0E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40730 6e9f88627328cdf8671e2d9973568b20 476 Pfam PF00083 Sugar (and other) transporter 56 445 1.8E-31 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS40730 6e9f88627328cdf8671e2d9973568b20 476 Gene3D G3DSA:1.20.1250.20 31 211 1.4E-25 T 17-03-2017 SHXM_RS40730 6e9f88627328cdf8671e2d9973568b20 476 Gene3D G3DSA:1.20.1250.20 268 451 2.4E-13 T 17-03-2017 SHXM_RS40730 6e9f88627328cdf8671e2d9973568b20 476 SUPERFAMILY SSF103473 24 453 3.79E-54 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS31330 182ac9d2bedc67ee0973571d436c0854 136 Pfam PF01740 STAS domain 19 101 1.7E-7 T 17-03-2017 IPR002645 STAS domain SHXM_RS31330 182ac9d2bedc67ee0973571d436c0854 136 SUPERFAMILY SSF52091 10 101 1.63E-17 T 17-03-2017 IPR002645 STAS domain SHXM_RS31330 182ac9d2bedc67ee0973571d436c0854 136 Gene3D G3DSA:3.30.750.24 13 101 1.1E-14 T 17-03-2017 IPR002645 STAS domain SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 Gene3D G3DSA:2.40.10.10 204 286 9.7E-29 T 17-03-2017 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 Pfam PF02983 Alpha-lytic protease prodomain 126 185 8.9E-15 T 17-03-2017 IPR004236 Peptidase S1A, alpha-lytic prodomain GO:0005576|GO:0006508|GO:0008236 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 SUPERFAMILY SSF50494 207 385 9.32E-36 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 Gene3D G3DSA:3.30.300.50 44 124 1.1E-28 T 17-03-2017 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 Gene3D G3DSA:2.40.10.10 287 376 1.6E-30 T 17-03-2017 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 PIRSF PIRSF001134 2 391 4.2E-138 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 311 328 8.7E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 290 310 8.7E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 354 368 8.7E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 230 244 8.7E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 PRINTS PR00861 Alpha-lytic endopeptidase serine protease (S2A) signature 330 353 8.7E-41 T 17-03-2017 IPR001316 Peptidase S1A, streptogrisin GO:0004252|GO:0006508 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 Gene3D G3DSA:3.30.300.50 125 196 1.1E-18 T 17-03-2017 SHXM_RS14325 6815fc4ebfb6eca1e0381649289ca89e 391 SUPERFAMILY SSF54806 127 193 3.92E-5 T 17-03-2017 SHXM_RS43070 c2f9349a3787594132dd00d3ebc8b81a 311 Pfam PF01435 Peptidase family M48 141 224 3.1E-9 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS43070 c2f9349a3787594132dd00d3ebc8b81a 311 Gene3D G3DSA:3.30.2010.10 142 197 1.1E-8 T 17-03-2017 SHXM_RS46050 b4ba5823502019dffd693dad881fe8ab 396 SUPERFAMILY SSF55874 273 377 2.48E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS46050 b4ba5823502019dffd693dad881fe8ab 396 Pfam PF07730 Histidine kinase 202 269 1.6E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 SMART SM00525 208 228 5.4E-4 T 17-03-2017 IPR003651 Endonuclease III-like, iron-sulphur cluster loop motif GO:0051539 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 SUPERFAMILY SSF48150 23 235 2.51E-63 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 ProSitePatterns PS01155 Endonuclease III family signature. 118 147 - T 17-03-2017 IPR004036 Endonuclease III-like, conserved site-2 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 Gene3D G3DSA:1.10.340.30 38 138 2.4E-34 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 Pfam PF00633 Helix-hairpin-helix motif 115 144 2.5E-7 T 17-03-2017 IPR000445 Helix-hairpin-helix motif GO:0003677 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 51 178 5.8E-11 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 SMART SM00478 55 207 4.9E-36 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS30285 91198acbb5b66f46b78a910e672dea61 308 Gene3D G3DSA:1.10.1670.10 139 235 4.0E-35 T 17-03-2017 IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal Reactome: R-HSA-110357 SHXM_RS42440 62f43f423619c2c33d9baef8b9474ac9 238 SUPERFAMILY SSF56784 9 235 1.37E-36 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42440 62f43f423619c2c33d9baef8b9474ac9 238 Pfam PF13419 Haloacid dehalogenase-like hydrolase 56 200 8.8E-12 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS42440 62f43f423619c2c33d9baef8b9474ac9 238 Gene3D G3DSA:3.40.50.1000 62 234 1.4E-30 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS40490 a0923b6d8258754d90417f7b99626ede 186 SUPERFAMILY SSF46689 6 78 6.98E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS40490 a0923b6d8258754d90417f7b99626ede 186 Gene3D G3DSA:1.10.357.10 6 183 1.3E-34 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS40490 a0923b6d8258754d90417f7b99626ede 186 SUPERFAMILY SSF48498 81 182 1.05E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS40490 a0923b6d8258754d90417f7b99626ede 186 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 61 2.0E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47230 2397b7c579c74cfc02d32679f02e9fe8 588 Gene3D G3DSA:3.20.20.70 191 400 1.4E-21 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS47230 2397b7c579c74cfc02d32679f02e9fe8 588 SUPERFAMILY SSF51445 186 482 8.26E-36 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS47230 2397b7c579c74cfc02d32679f02e9fe8 588 Pfam PF02065 Melibiase 187 333 1.6E-12 T 17-03-2017 IPR002252 Glycoside hydrolase family 36 GO:0004557|GO:0005975 KEGG: 00052+3.2.1.22|KEGG: 00561+3.2.1.22|KEGG: 00600+3.2.1.22|KEGG: 00603+3.2.1.22|MetaCyc: PWY-6527 SHXM_RS21965 597c2a3590d01fbf8a8672b7a29544a9 481 SMART SM00327 91 262 1.5E-11 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS21965 597c2a3590d01fbf8a8672b7a29544a9 481 Gene3D G3DSA:3.40.50.410 92 261 2.9E-10 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS21965 597c2a3590d01fbf8a8672b7a29544a9 481 SUPERFAMILY SSF53300 92 268 4.15E-21 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS21965 597c2a3590d01fbf8a8672b7a29544a9 481 Pfam PF13519 von Willebrand factor type A domain 94 203 4.9E-9 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS33805 b5d4584fa0cba2d6a421360e526f9bfd 162 Gene3D G3DSA:3.90.79.10 2 129 3.4E-32 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS33805 b5d4584fa0cba2d6a421360e526f9bfd 162 Pfam PF00293 NUDIX domain 4 113 2.6E-19 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS33805 b5d4584fa0cba2d6a421360e526f9bfd 162 ProSitePatterns PS00893 Nudix box signature. 37 58 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS33805 b5d4584fa0cba2d6a421360e526f9bfd 162 SUPERFAMILY SSF55811 3 129 5.69E-31 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS33805 b5d4584fa0cba2d6a421360e526f9bfd 162 PRINTS PR00502 NUDIX hydrolase family signature 32 46 1.2E-7 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS33805 b5d4584fa0cba2d6a421360e526f9bfd 162 PRINTS PR00502 NUDIX hydrolase family signature 46 61 1.2E-7 T 17-03-2017 IPR020476 NUDIX hydrolase Reactome: R-HSA-2393930 SHXM_RS23610 2b15c1de5605768ee59cece92a459719 291 Gene3D G3DSA:3.40.50.1820 2 286 7.5E-51 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23610 2b15c1de5605768ee59cece92a459719 291 Pfam PF00561 alpha/beta hydrolase fold 26 269 1.4E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS23610 2b15c1de5605768ee59cece92a459719 291 SUPERFAMILY SSF53474 3 287 6.1E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 Gene3D G3DSA:3.50.50.60 66 96 3.7E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 Gene3D G3DSA:3.50.50.60 452 517 3.7E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 Gene3D G3DSA:3.50.50.60 271 351 3.7E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 Pfam PF01593 Flavin containing amine oxidoreductase 77 514 3.4E-54 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 Gene3D G3DSA:3.90.660.10 355 399 3.5E-15 T 17-03-2017 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 Gene3D G3DSA:3.90.660.10 97 165 3.5E-15 T 17-03-2017 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 PRINTS PR00757 Flavin-containing amine oxidase signature 464 486 1.3E-12 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 PRINTS PR00757 Flavin-containing amine oxidase signature 355 374 1.3E-12 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 PRINTS PR00757 Flavin-containing amine oxidase signature 495 512 1.3E-12 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 PRINTS PR00757 Flavin-containing amine oxidase signature 69 88 1.3E-12 T 17-03-2017 IPR001613 Flavin amine oxidase GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 SUPERFAMILY SSF54373 351 464 8.5E-9 T 17-03-2017 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 SUPERFAMILY SSF51905 452 517 7.77E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS19455 3328864ba01412b78a70edc178db3b45 520 SUPERFAMILY SSF51905 67 366 7.77E-58 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS08015 70ab5110f4078e82247c742c56b29332 452 SUPERFAMILY SSF54675 3 131 4.71E-30 T 17-03-2017 SHXM_RS08015 70ab5110f4078e82247c742c56b29332 452 Pfam PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family 150 339 1.2E-7 T 17-03-2017 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 SHXM_RS08015 70ab5110f4078e82247c742c56b29332 452 PIRSF PIRSF000484 1 438 4.0E-114 T 17-03-2017 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 SHXM_RS08015 70ab5110f4078e82247c742c56b29332 452 TIGRFAM TIGR01513 NAPRTase_put: nicotinate phosphoribosyltransferase 4 414 7.2E-128 T 17-03-2017 IPR006405 Nicotinate phosphoribosyltransferase pncB-type GO:0004516|GO:0019358 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 SHXM_RS08015 70ab5110f4078e82247c742c56b29332 452 Gene3D G3DSA:3.20.140.10 3 354 1.1E-85 T 17-03-2017 SHXM_RS08015 70ab5110f4078e82247c742c56b29332 452 SUPERFAMILY SSF51690 133 436 1.62E-89 T 17-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 SHXM_RS19855 96d961c5b844b077ec9cc19e8e013fbc 375 Pfam PF12822 Protein of unknown function (DUF3816) 133 302 2.6E-19 T 17-03-2017 IPR024529 ECF transporter, substrate-specific component GO:0005215 SHXM_RS05045 17460d5bb9ec708bb0883c6847d1c7e9 304 Gene3D G3DSA:3.30.420.40 4 141 7.0E-23 T 17-03-2017 SHXM_RS05045 17460d5bb9ec708bb0883c6847d1c7e9 304 SUPERFAMILY SSF53067 4 301 8.65E-44 T 17-03-2017 SHXM_RS05045 17460d5bb9ec708bb0883c6847d1c7e9 304 Pfam PF00480 ROK family 4 300 9.5E-43 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS05045 17460d5bb9ec708bb0883c6847d1c7e9 304 Gene3D G3DSA:3.30.420.40 142 285 8.8E-43 T 17-03-2017 SHXM_RS16325 4953c3b10056aaef65fab3eadf48f87e 334 Pfam PF03403 Platelet-activating factor acetylhydrolase, isoform II 48 101 6.3E-7 T 17-03-2017 IPR005065 Platelet-activating factor acetylhydrolase GO:0003847|GO:0016042 KEGG: 00565+3.1.1.47 SHXM_RS16325 4953c3b10056aaef65fab3eadf48f87e 334 Gene3D G3DSA:3.40.50.1820 57 331 1.4E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16325 4953c3b10056aaef65fab3eadf48f87e 334 Gene3D G3DSA:3.40.50.1820 2 8 1.4E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16325 4953c3b10056aaef65fab3eadf48f87e 334 SUPERFAMILY SSF53474 47 265 7.17E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16325 4953c3b10056aaef65fab3eadf48f87e 334 SUPERFAMILY SSF53474 296 316 7.17E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40040 6f54e28de1b2f1141708df14e9000f0a 87 Pfam PF02148 Zn-finger in ubiquitin-hydrolases and other protein 23 85 1.2E-11 T 17-03-2017 IPR001607 Zinc finger, UBP-type GO:0008270 SHXM_RS40040 6f54e28de1b2f1141708df14e9000f0a 87 SUPERFAMILY SSF57850 7 85 3.53E-24 T 17-03-2017 SHXM_RS40040 6f54e28de1b2f1141708df14e9000f0a 87 Gene3D G3DSA:3.30.40.10 7 85 3.0E-21 T 17-03-2017 IPR013083 Zinc finger, RING/FYVE/PHD-type SHXM_RS35305 98219f0ed24d7216340f17b739424313 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 60 6.0E-16 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35305 98219f0ed24d7216340f17b739424313 213 Gene3D G3DSA:1.10.10.60 6 58 2.5E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35305 98219f0ed24d7216340f17b739424313 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 9.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35305 98219f0ed24d7216340f17b739424313 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 9.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35305 98219f0ed24d7216340f17b739424313 213 Gene3D G3DSA:1.10.357.10 59 198 1.2E-10 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS35305 98219f0ed24d7216340f17b739424313 213 SUPERFAMILY SSF46689 5 77 8.48E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11995 f05cdcfd9bed6e2ba632c5642687cb85 537 Pfam PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase 34 441 2.1E-40 T 17-03-2017 IPR002591 Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase GO:0003824 SHXM_RS11995 f05cdcfd9bed6e2ba632c5642687cb85 537 SUPERFAMILY SSF53649 27 476 8.0E-45 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS11995 f05cdcfd9bed6e2ba632c5642687cb85 537 Gene3D G3DSA:3.40.720.10 28 359 1.3E-42 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS03230 c57e7fe9d5261e3acbbdfe0efaa173d8 202 Pfam PF02441 Flavoprotein 2 129 1.3E-25 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS03230 c57e7fe9d5261e3acbbdfe0efaa173d8 202 SUPERFAMILY SSF52507 2 185 2.49E-61 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS03230 c57e7fe9d5261e3acbbdfe0efaa173d8 202 Hamap MF_01984 Flavin prenyltransferase UbiX [ubiX]. 1 185 37.208 T 17-03-2017 IPR004507 Flavin prenyltransferase UbiX/Pad1 SHXM_RS03230 c57e7fe9d5261e3acbbdfe0efaa173d8 202 Gene3D G3DSA:3.40.50.1950 2 186 1.4E-77 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS03230 c57e7fe9d5261e3acbbdfe0efaa173d8 202 Hamap MF_01986 Probable UbiX-like flavin prenyltransferase. 1 189 50.956 T 17-03-2017 IPR032901 Probable UbiX-like flavin prenyltransferase SHXM_RS03230 c57e7fe9d5261e3acbbdfe0efaa173d8 202 TIGRFAM TIGR00421 ubiX_pad: polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases 2 183 9.0E-74 T 17-03-2017 IPR004507 Flavin prenyltransferase UbiX/Pad1 SHXM_RS19955 cd569eb0d112318f7991b667a62a500d 381 Gene3D G3DSA:3.40.710.10 9 376 3.3E-70 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS19955 cd569eb0d112318f7991b667a62a500d 381 Pfam PF00144 Beta-lactamase 19 370 6.2E-58 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS19955 cd569eb0d112318f7991b667a62a500d 381 SUPERFAMILY SSF56601 9 370 1.08E-65 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS37585 d6d3d1f22b46c925d44ae6098ef7b20d 418 Gene3D G3DSA:1.20.1250.20 217 399 9.9E-18 T 17-03-2017 SHXM_RS37585 d6d3d1f22b46c925d44ae6098ef7b20d 418 Gene3D G3DSA:1.20.1250.20 21 194 1.8E-6 T 17-03-2017 SHXM_RS37585 d6d3d1f22b46c925d44ae6098ef7b20d 418 SUPERFAMILY SSF103473 20 398 2.22E-32 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS37585 d6d3d1f22b46c925d44ae6098ef7b20d 418 Pfam PF07690 Major Facilitator Superfamily 223 404 3.0E-15 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS30240 170ad9292baf5894feb4c28505d66045 215 SUPERFAMILY SSF51261 73 208 7.85E-44 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS30240 170ad9292baf5894feb4c28505d66045 215 Pfam PF01551 Peptidase family M23 102 203 7.6E-32 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS30240 170ad9292baf5894feb4c28505d66045 215 Gene3D G3DSA:2.70.70.10 56 209 3.2E-45 T 17-03-2017 SHXM_RS26305 9a7dc3197dbfc35e4762020e09520e4d 131 SUPERFAMILY SSF46785 3 114 4.13E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26305 9a7dc3197dbfc35e4762020e09520e4d 131 Pfam PF03965 Penicillinase repressor 5 113 7.1E-23 T 17-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SHXM_RS26305 9a7dc3197dbfc35e4762020e09520e4d 131 Gene3D G3DSA:1.10.10.10 4 80 6.2E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27105 ed1c2bfa5d8a12b2d6970e113a546db3 124 Pfam PF12680 SnoaL-like domain 8 101 1.4E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS27105 ed1c2bfa5d8a12b2d6970e113a546db3 124 SUPERFAMILY SSF54427 1 123 3.63E-27 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS27105 ed1c2bfa5d8a12b2d6970e113a546db3 124 Gene3D G3DSA:3.10.450.50 2 109 3.4E-16 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS38005 5f3024aef06c4edac9eba31838769d7e 210 Pfam PF01081 KDPG and KHG aldolase 6 183 6.9E-39 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS38005 5f3024aef06c4edac9eba31838769d7e 210 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 5 200 1.6E-47 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS38005 5f3024aef06c4edac9eba31838769d7e 210 Gene3D G3DSA:3.20.20.70 4 208 1.7E-63 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS38005 5f3024aef06c4edac9eba31838769d7e 210 SUPERFAMILY SSF51569 3 205 8.61E-53 T 17-03-2017 SHXM_RS25495 f5929f3d17d110f7df948d075f2f0b54 524 SUPERFAMILY SSF109854 233 399 1.83E-13 T 17-03-2017 SHXM_RS25495 f5929f3d17d110f7df948d075f2f0b54 524 Pfam PF13490 Putative zinc-finger 162 192 1.1E-6 T 17-03-2017 IPR027383 Putative zinc-finger SHXM_RS05210 5d53086ed4ce5af8c94f2bc71da68a2f 210 SUPERFAMILY SSF46689 10 76 6.98E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS05210 5d53086ed4ce5af8c94f2bc71da68a2f 210 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 1.0E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05210 5d53086ed4ce5af8c94f2bc71da68a2f 210 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 45 68 1.0E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05210 5d53086ed4ce5af8c94f2bc71da68a2f 210 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 70 2.9E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS05210 5d53086ed4ce5af8c94f2bc71da68a2f 210 Gene3D G3DSA:1.10.357.10 7 203 4.4E-23 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS13030 886c9994947b9b7324910c120b6d9314 173 Pfam PF13302 Acetyltransferase (GNAT) domain 10 140 1.3E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS13030 886c9994947b9b7324910c120b6d9314 173 Gene3D G3DSA:3.40.630.30 1 170 7.6E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS13030 886c9994947b9b7324910c120b6d9314 173 SUPERFAMILY SSF55729 1 169 5.05E-34 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 Gene3D G3DSA:3.40.50.300 273 420 1.4E-41 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 Gene3D G3DSA:3.40.50.300 49 272 2.9E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 SUPERFAMILY SSF52540 134 418 3.31E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 SMART SM00487 82 282 9.9E-52 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 Pfam PF00270 DEAD/DEAH box helicase 87 254 3.4E-43 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 Pfam PF00271 Helicase conserved C-terminal domain 299 397 2.0E-22 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS29670 21aa1d647347d848358c4f90819d5f0b 773 SMART SM00490 316 397 2.6E-28 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS01010 9d0030fac79b27e5477e295a9cd06122 319 Pfam PF13407 Periplasmic binding protein domain 45 294 8.7E-53 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS01010 9d0030fac79b27e5477e295a9cd06122 319 Gene3D G3DSA:3.40.50.2300 43 157 8.9E-32 T 17-03-2017 SHXM_RS01010 9d0030fac79b27e5477e295a9cd06122 319 Gene3D G3DSA:3.40.50.2300 158 298 3.3E-45 T 17-03-2017 SHXM_RS01010 9d0030fac79b27e5477e295a9cd06122 319 SUPERFAMILY SSF53822 43 315 7.24E-71 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS06745 6fef7cb6c77b88718147e0ef297b2cba 209 Pfam PF11706 CGNR zinc finger 159 201 1.5E-17 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS06745 6fef7cb6c77b88718147e0ef297b2cba 209 Gene3D G3DSA:1.10.3300.10 20 202 1.2E-40 T 17-03-2017 IPR023286 ABATE domain SHXM_RS06745 6fef7cb6c77b88718147e0ef297b2cba 209 Pfam PF07336 Putative stress-induced transcription regulator 25 153 1.7E-19 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS06745 6fef7cb6c77b88718147e0ef297b2cba 209 SUPERFAMILY SSF160904 19 200 3.27E-37 T 17-03-2017 SHXM_RS35280 c04802178b19b6969faf5afd4db39964 377 Pfam PF07730 Histidine kinase 161 224 6.5E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS35280 c04802178b19b6969faf5afd4db39964 377 SUPERFAMILY SSF55874 265 354 1.07E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20685 8f9a31124317a0690868f0dc818fe13e 465 Gene3D G3DSA:3.30.565.10 193 310 1.8E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20685 8f9a31124317a0690868f0dc818fe13e 465 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 199 306 5.5E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20685 8f9a31124317a0690868f0dc818fe13e 465 SUPERFAMILY SSF55874 184 307 2.23E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43375 47ee80877dcf8a64ed7403be1166bf51 226 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 5.8E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS43375 47ee80877dcf8a64ed7403be1166bf51 226 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 5.8E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS43375 47ee80877dcf8a64ed7403be1166bf51 226 SUPERFAMILY SSF48498 86 192 3.5E-20 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS43375 47ee80877dcf8a64ed7403be1166bf51 226 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 67 1.7E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS43375 47ee80877dcf8a64ed7403be1166bf51 226 SUPERFAMILY SSF46689 12 83 1.07E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS43375 47ee80877dcf8a64ed7403be1166bf51 226 Gene3D G3DSA:1.10.357.10 10 198 1.0E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS27110 e0f0075824f35f4ad1cadf201726f1ac 622 SUPERFAMILY SSF53474 366 606 5.97E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27110 e0f0075824f35f4ad1cadf201726f1ac 622 Gene3D G3DSA:3.40.50.1820 346 606 2.7E-72 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27110 e0f0075824f35f4ad1cadf201726f1ac 622 Gene3D G3DSA:3.40.50.1820 48 89 2.7E-72 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27110 e0f0075824f35f4ad1cadf201726f1ac 622 Pfam PF00326 Prolyl oligopeptidase family 406 607 1.2E-39 T 17-03-2017 IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain GO:0006508|GO:0008236 SHXM_RS27110 e0f0075824f35f4ad1cadf201726f1ac 622 SUPERFAMILY SSF82171 37 333 8.24E-26 T 17-03-2017 SHXM_RS27110 e0f0075824f35f4ad1cadf201726f1ac 622 Gene3D G3DSA:2.120.10.60 127 330 2.3E-11 T 17-03-2017 SHXM_RS36575 1c5770f2de48ce3ed0f156deb79e3d28 79 Gene3D G3DSA:3.30.300.120 5 63 9.2E-6 T 17-03-2017 SHXM_RS36575 1c5770f2de48ce3ed0f156deb79e3d28 79 SUPERFAMILY SSF54814 16 62 1.83E-8 T 17-03-2017 IPR009019 K homology domain, prokaryotic type GO:0003723 SHXM_RS36575 1c5770f2de48ce3ed0f156deb79e3d28 79 Pfam PF13083 KH domain 3 64 3.2E-19 T 17-03-2017 SHXM_RS36575 1c5770f2de48ce3ed0f156deb79e3d28 79 Hamap MF_00088 UPF0109 protein . 2 73 21.565 T 17-03-2017 IPR020627 Uncharacterised protein family UPF0109 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 PRINTS PR00406 Cytochrome B5 reductase signature 129 148 3.5E-6 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 PRINTS PR00406 Cytochrome B5 reductase signature 107 121 3.5E-6 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 PRINTS PR00406 Cytochrome B5 reductase signature 46 57 3.5E-6 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 Gene3D G3DSA:2.40.30.10 15 110 1.2E-21 T 17-03-2017 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 Pfam PF00175 Oxidoreductase NAD-binding domain 132 239 1.5E-7 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 SUPERFAMILY SSF54292 248 367 5.9E-26 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 316 324 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 SUPERFAMILY SSF52343 110 255 2.36E-28 T 17-03-2017 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 Gene3D G3DSA:3.40.50.80 111 251 7.4E-31 T 17-03-2017 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 SUPERFAMILY SSF63380 15 123 3.58E-21 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 285 358 3.5E-13 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 Gene3D G3DSA:3.10.20.30 252 366 5.9E-30 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS28310 74a3f8ea8ebb24a1457b092a3f0d9758 369 Pfam PF00970 Oxidoreductase FAD-binding domain 20 119 5.0E-10 T 17-03-2017 IPR008333 Oxidoreductase, FAD-binding domain Reactome: R-HSA-1237044 SHXM_RS28865 1cc7179b1924e30233c1a43b71cb4e8e 145 SUPERFAMILY SSF54427 7 142 3.51E-25 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS28865 1cc7179b1924e30233c1a43b71cb4e8e 145 Pfam PF12680 SnoaL-like domain 13 129 6.5E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS28865 1cc7179b1924e30233c1a43b71cb4e8e 145 Gene3D G3DSA:3.10.450.50 8 143 3.6E-27 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 Gene3D G3DSA:3.40.50.720 5 254 6.9E-86 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 SUPERFAMILY SSF51735 5 254 6.44E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 253 1.6E-70 T 17-03-2017 SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 5.9E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 85 96 5.9E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 5.9E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 1.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 1.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 85 96 1.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 11 28 1.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 1.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47540 e2309e5b2f70269403255f409850fe83 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 1.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08125 13fdf36ca60d804e68717cef960e6aed 449 SUPERFAMILY SSF53850 49 434 4.92E-67 T 17-03-2017 SHXM_RS08125 13fdf36ca60d804e68717cef960e6aed 449 Pfam PF01547 Bacterial extracellular solute-binding protein 59 343 3.1E-39 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS08125 13fdf36ca60d804e68717cef960e6aed 449 Gene3D G3DSA:3.40.190.10 159 330 5.3E-35 T 17-03-2017 SHXM_RS08125 13fdf36ca60d804e68717cef960e6aed 449 Gene3D G3DSA:3.40.190.10 46 157 3.5E-28 T 17-03-2017 SHXM_RS08125 13fdf36ca60d804e68717cef960e6aed 449 Gene3D G3DSA:3.40.190.10 331 363 3.5E-28 T 17-03-2017 SHXM_RS10530 2425be816eb09dfbd7af514db992ff23 307 Gene3D G3DSA:1.10.1660.10 12 122 6.3E-24 T 17-03-2017 SHXM_RS10530 2425be816eb09dfbd7af514db992ff23 307 SMART SM00422 11 80 2.8E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS10530 2425be816eb09dfbd7af514db992ff23 307 Pfam PF00376 MerR family regulatory protein 12 49 1.6E-11 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS10530 2425be816eb09dfbd7af514db992ff23 307 SUPERFAMILY SSF46955 12 121 3.0E-20 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS15355 36649d63849d08571894918b5c846beb 387 Gene3D G3DSA:3.20.20.30 9 346 1.1E-74 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS15355 36649d63849d08571894918b5c846beb 387 SUPERFAMILY SSF51679 10 346 9.03E-72 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS15355 36649d63849d08571894918b5c846beb 387 Pfam PF00296 Luciferase-like monooxygenase 9 309 5.4E-44 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16405 e8a0fb4e32363141afdf0410c1000e24 153 Pfam PF01575 MaoC like domain 15 131 4.7E-27 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS16405 e8a0fb4e32363141afdf0410c1000e24 153 Gene3D G3DSA:3.10.129.10 12 151 4.4E-38 T 17-03-2017 IPR029069 HotDog domain SHXM_RS16405 e8a0fb4e32363141afdf0410c1000e24 153 SUPERFAMILY SSF54637 11 150 5.12E-40 T 17-03-2017 IPR029069 HotDog domain SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 Pfam PF00107 Zinc-binding dehydrogenase 157 296 5.3E-21 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 SUPERFAMILY SSF51735 124 307 1.4E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 SMART SM00829 20 340 2.7E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 Pfam PF16884 N-terminal domain of oxidoreductase 7 113 5.0E-25 T 17-03-2017 SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 Gene3D G3DSA:3.90.180.10 3 140 3.2E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 Gene3D G3DSA:3.40.50.720 141 309 3.2E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32015 f4287605766f871ab56b1483aa4e0352 342 SUPERFAMILY SSF50129 5 129 4.88E-27 T 17-03-2017 IPR011032 GroES-like SHXM_RS31075 0a3db13aa2db7b9dce3c7b9c87975a28 97 Gene3D G3DSA:1.20.5.1030 38 96 9.9E-22 T 17-03-2017 SHXM_RS31075 0a3db13aa2db7b9dce3c7b9c87975a28 97 Pfam PF00584 SecE/Sec61-gamma subunits of protein translocation complex 44 94 6.2E-18 T 17-03-2017 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31075 0a3db13aa2db7b9dce3c7b9c87975a28 97 Hamap MF_00422 Protein translocase subunit SecE [secE]. 39 94 12.973 T 17-03-2017 IPR022943 Preprotein translocase subunit SecE Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31075 0a3db13aa2db7b9dce3c7b9c87975a28 97 ProSitePatterns PS01067 Protein secE/sec61-gamma signature. 44 72 - T 17-03-2017 IPR001901 Protein translocase complex, SecE/Sec61-gamma subunit GO:0006605|GO:0006886|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31075 0a3db13aa2db7b9dce3c7b9c87975a28 97 TIGRFAM TIGR00964 secE_bact: preprotein translocase, SecE subunit 43 97 1.2E-21 T 17-03-2017 IPR005807 SecE subunit of protein translocation complex GO:0009306|GO:0015450|GO:0016021 SHXM_RS18330 e317b1d73dd94a4d4fdab5e347212289 231 TIGRFAM TIGR02234 trp_oprn_chp: membrane protein, TIGR02234 family 24 220 2.4E-40 T 17-03-2017 IPR011746 Trp biosynthesis associated, conserved hypothetical membrane protein SHXM_RS18330 e317b1d73dd94a4d4fdab5e347212289 231 Pfam PF09534 Tryptophan-associated transmembrane protein (Trp_oprn_chp) 32 219 6.5E-54 T 17-03-2017 IPR019051 Trp biosynthesis associated, transmembrane protein, Oprn/Chp SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 SUPERFAMILY SSF52172 7 134 3.98E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 SUPERFAMILY SSF46894 155 221 2.24E-18 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 SMART SM00448 8 121 1.7E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 180 196 1.7E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 166 180 1.7E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 196 208 1.7E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 ProSitePatterns PS00622 LuxR-type HTH domain signature. 180 207 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 Pfam PF00072 Response regulator receiver domain 10 121 2.9E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 Gene3D G3DSA:3.40.50.2300 4 128 2.3E-34 T 17-03-2017 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 Pfam PF00196 Bacterial regulatory proteins, luxR family 165 219 4.6E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 Gene3D G3DSA:1.10.10.10 129 221 1.6E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20135 3529d173b7b35661ff6613cb8aa3878b 225 SMART SM00421 163 220 1.0E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS20430 caf1a98d8390e098093ca8c96e113719 263 Pfam PF00775 Dioxygenase 68 163 1.9E-9 T 17-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 SHXM_RS20430 caf1a98d8390e098093ca8c96e113719 263 Gene3D G3DSA:2.60.130.10 49 228 1.9E-45 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS20430 caf1a98d8390e098093ca8c96e113719 263 SUPERFAMILY SSF49482 51 261 3.14E-44 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS47955 1fe66ea5870d2e9b4c4e02d07f2b2ff5 105 Pfam PF02426 Muconolactone delta-isomerase 43 78 9.9E-8 T 17-03-2017 IPR026029 Muconolactone isomerase domain KEGG: 00362+5.3.3.4|MetaCyc: PWY-6185 SHXM_RS47955 1fe66ea5870d2e9b4c4e02d07f2b2ff5 105 SUPERFAMILY SSF54909 42 78 5.9E-6 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS33045 85a2643eef6fca2f6657979d5a3ba2a1 147 Pfam PF05331 Protein of unknown function (DUF742) 27 135 2.2E-22 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 Gene3D G3DSA:3.20.20.140 145 422 1.3E-121 T 17-03-2017 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 Gene3D G3DSA:3.20.20.140 481 558 1.3E-121 T 17-03-2017 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 Pfam PF01979 Amidohydrolase family 126 446 2.8E-44 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 Pfam PF00449 Urease alpha-subunit, N-terminal domain 3 113 1.4E-33 T 17-03-2017 IPR011612 Urease alpha-subunit, N-terminal domain KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 Gene3D G3DSA:2.30.40.10 68 144 2.5E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 290 307 2.4E-23 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 420 433 2.4E-23 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 394 409 2.4E-23 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 PRINTS PR01752 Urea amidohydrolase (urease) protein signature 329 345 2.4E-23 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 SUPERFAMILY SSF51338 402 466 4.32E-39 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 SUPERFAMILY SSF51338 3 109 4.32E-39 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 Hamap MF_01953 Urease subunit alpha [ureC]. 2 561 39.618 T 17-03-2017 IPR005848 Urease, alpha subunit GO:0006807|GO:0009039|GO:0016151 KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 SUPERFAMILY SSF51556 474 559 8.85E-113 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS40515 e82151a67cd361319befabcef4ef07da 561 SUPERFAMILY SSF51556 130 425 8.85E-113 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS38530 a1e078adb4cda3f685545c87233b9c55 267 Gene3D G3DSA:3.10.450.40 127 169 6.2E-5 T 17-03-2017 SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 Pfam PF00106 short chain dehydrogenase 3 186 7.2E-51 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 6.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 122 138 6.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 148 167 6.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 6.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 6.1E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 Gene3D G3DSA:3.40.50.720 2 248 7.2E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 135 163 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 148 167 2.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 2.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 128 136 2.1E-8 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 SUPERFAMILY SSF51735 2 248 5.55E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47545 284ae6efd584529d7dbcb2c1f454c421 281 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 3 161 0.0041 T 17-03-2017 SHXM_RS18765 700445300291fe319f42f2592ebcc079 411 SMART SM00387 300 399 0.003 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18765 700445300291fe319f42f2592ebcc079 411 Pfam PF07730 Histidine kinase 181 217 6.5E-6 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS18765 700445300291fe319f42f2592ebcc079 411 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 308 398 1.6E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18765 700445300291fe319f42f2592ebcc079 411 SUPERFAMILY SSF55874 278 397 1.15E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18765 700445300291fe319f42f2592ebcc079 411 Gene3D G3DSA:3.30.565.10 298 398 8.2E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19700 80b1f12ea9ab2502812a5c7dc869dc46 219 ProSitePatterns PS00159 KDPG and KHG aldolases active site. 47 56 - T 17-03-2017 IPR031337 KDPG/KHG aldolase, active site 1 KEGG: 00030+4.1.2.14|KEGG: 00330+4.1.3.16|KEGG: 00630+4.1.3.16|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS19700 80b1f12ea9ab2502812a5c7dc869dc46 219 Gene3D G3DSA:3.20.20.70 19 216 6.6E-75 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS19700 80b1f12ea9ab2502812a5c7dc869dc46 219 Pfam PF01081 KDPG and KHG aldolase 18 209 2.9E-70 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS19700 80b1f12ea9ab2502812a5c7dc869dc46 219 ProSitePatterns PS00160 KDPG and KHG aldolases Schiff-base forming residue. 135 148 - T 17-03-2017 IPR031338 KDPG/KHG aldolase, active site 2 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS19700 80b1f12ea9ab2502812a5c7dc869dc46 219 SUPERFAMILY SSF51569 19 216 3.11E-66 T 17-03-2017 SHXM_RS19700 80b1f12ea9ab2502812a5c7dc869dc46 219 TIGRFAM TIGR01182 eda: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase 17 216 1.2E-76 T 17-03-2017 IPR000887 KDPG/KHG aldolase GO:0008152|GO:0016829 KEGG: 00030+4.1.2.14|MetaCyc: PWY-2221|MetaCyc: PWY-6507|MetaCyc: PWY-7242|MetaCyc: PWY-7310|MetaCyc: PWY-7562 SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 Gene3D G3DSA:3.40.50.2300 14 139 1.7E-41 T 17-03-2017 SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 Pfam PF00072 Response regulator receiver domain 22 131 5.2E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 SUPERFAMILY SSF52172 18 198 2.42E-43 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 SMART SM00448 20 131 6.5E-43 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 Pfam PF00486 Transcriptional regulatory protein, C terminal 167 240 3.4E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 Gene3D G3DSA:1.10.10.10 144 243 1.2E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27420 9982dd1de13690a71bf871bcd86a039d 245 SMART SM00862 167 241 8.5E-27 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS14585 0403a545a3efdc16aa411584cf1c4e7a 262 SMART SM01012 172 227 9.6E-18 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS14585 0403a545a3efdc16aa411584cf1c4e7a 262 Gene3D G3DSA:3.30.450.40 22 168 3.1E-5 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS14585 0403a545a3efdc16aa411584cf1c4e7a 262 Pfam PF03861 ANTAR domain 174 227 9.6E-19 T 17-03-2017 IPR005561 ANTAR domain GO:0003723 SHXM_RS14585 0403a545a3efdc16aa411584cf1c4e7a 262 SUPERFAMILY SSF52172 96 226 3.73E-9 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS14585 0403a545a3efdc16aa411584cf1c4e7a 262 Gene3D G3DSA:1.10.10.10 175 230 1.4E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12855 4114575b69a008771d97a6ef89d221c3 224 Gene3D G3DSA:3.40.1130.10 6 207 9.7E-35 T 17-03-2017 SHXM_RS12855 4114575b69a008771d97a6ef89d221c3 224 Pfam PF01553 Acyltransferase 21 151 1.4E-21 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS12855 4114575b69a008771d97a6ef89d221c3 224 SMART SM00563 35 154 5.8E-35 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS12855 4114575b69a008771d97a6ef89d221c3 224 SUPERFAMILY SSF69593 4 221 3.14E-51 T 17-03-2017 SHXM_RS09395 ca07ac8bfc00b80db0fb88b0b05a2656 84 SUPERFAMILY SSF46689 24 69 1.45E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09395 ca07ac8bfc00b80db0fb88b0b05a2656 84 Gene3D G3DSA:1.10.10.60 24 69 1.6E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09395 ca07ac8bfc00b80db0fb88b0b05a2656 84 Pfam PF02796 Helix-turn-helix domain of resolvase 24 63 5.7E-8 T 17-03-2017 IPR006120 Resolvase, HTH domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 SUPERFAMILY SSF48498 104 212 4.52E-23 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 Gene3D G3DSA:1.10.357.10 59 213 3.4E-40 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 2.1E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 2.1E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 SUPERFAMILY SSF46689 1 78 6.67E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 61 5.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45635 c96b7935452da29b8227c4a59fa6674e 230 Gene3D G3DSA:1.10.10.60 12 58 3.3E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15335 f2befbb38ef21d604ecaee9aeea3e29b 221 Gene3D G3DSA:1.10.150.130 59 159 2.0E-10 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS15335 f2befbb38ef21d604ecaee9aeea3e29b 221 Pfam PF14659 Phage integrase, N-terminal SAM-like domain 60 113 1.9E-9 T 17-03-2017 IPR004107 Integrase, SAM-like, N-terminal GO:0003677|GO:0015074 SHXM_RS15335 f2befbb38ef21d604ecaee9aeea3e29b 221 SUPERFAMILY SSF56349 60 199 4.71E-22 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS05140 822c790dbf6484ff74d39c8eec0f3aed 608 Gene3D G3DSA:3.50.50.60 391 575 6.3E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05140 822c790dbf6484ff74d39c8eec0f3aed 608 Gene3D G3DSA:3.50.50.60 68 282 1.0E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05140 822c790dbf6484ff74d39c8eec0f3aed 608 SUPERFAMILY SSF51905 404 530 1.26E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05140 822c790dbf6484ff74d39c8eec0f3aed 608 SUPERFAMILY SSF51905 77 312 1.26E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05140 822c790dbf6484ff74d39c8eec0f3aed 608 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 76 269 1.2E-10 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42120 e95ad11a3819a62e8dfc9be3751c676a 338 Gene3D G3DSA:3.20.20.30 14 326 4.4E-52 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42120 e95ad11a3819a62e8dfc9be3751c676a 338 SUPERFAMILY SSF51679 15 326 1.15E-49 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42120 e95ad11a3819a62e8dfc9be3751c676a 338 Pfam PF00296 Luciferase-like monooxygenase 41 251 3.9E-36 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42120 e95ad11a3819a62e8dfc9be3751c676a 338 TIGRFAM TIGR03571 lucif_BA3436: luciferase-type oxidoreductase, BA3436 family 13 326 1.3E-106 T 17-03-2017 IPR020020 Luciferase-type oxidoreductase SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 Gene3D G3DSA:3.50.50.60 9 263 1.6E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 Gene3D G3DSA:3.50.50.60 429 491 1.6E-65 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 Gene3D G3DSA:3.90.700.10 296 422 4.5E-20 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 Pfam PF00890 FAD binding domain 9 471 2.1E-50 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 SUPERFAMILY SSF56425 296 433 2.59E-22 T 17-03-2017 IPR027477 Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 SUPERFAMILY SSF51905 9 260 4.8E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38385 24458982456a73fa6b799e453067dea7 498 SUPERFAMILY SSF51905 427 493 4.8E-44 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39010 2f8f3b54e32b318a603c818bee719df3 1058 SUPERFAMILY SSF52540 283 417 2.95E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39010 2f8f3b54e32b318a603c818bee719df3 1058 SUPERFAMILY SSF52058 807 1006 1.41E-10 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS39010 2f8f3b54e32b318a603c818bee719df3 1058 Gene3D G3DSA:3.80.10.10 817 1005 9.4E-9 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS39010 2f8f3b54e32b318a603c818bee719df3 1058 Pfam PF05729 NACHT domain 290 449 8.1E-23 T 17-03-2017 SHXM_RS39010 2f8f3b54e32b318a603c818bee719df3 1058 Gene3D G3DSA:3.40.50.300 284 412 3.1E-4 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 SUPERFAMILY SSF46785 4 87 3.53E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 Gene3D G3DSA:1.10.10.10 1 83 6.0E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 Pfam PF03466 LysR substrate binding domain 87 267 9.7E-22 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 3.1E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 3.1E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 3.1E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 Gene3D G3DSA:3.40.190.10 171 252 1.8E-15 T 17-03-2017 SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 Gene3D G3DSA:3.40.190.10 89 170 3.5E-6 T 17-03-2017 SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 SUPERFAMILY SSF53850 87 282 2.35E-21 T 17-03-2017 SHXM_RS49925 6a8409f5f2badcc87307cda774a5b5af 286 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 4.7E-20 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 Hamap MF_00577 Urocanate hydratase [hutU]. 2 550 48.974 T 17-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 ProSitePatterns PS01233 Urocanase signature. 436 451 - T 17-03-2017 IPR023636 Urocanase conserved site GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 Gene3D G3DSA:3.40.50.10730 137 343 4.4E-83 T 17-03-2017 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 TIGRFAM TIGR01228 hutU: urocanate hydratase 6 548 2.0E-271 T 17-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 PIRSF PIRSF001423 1 552 6.1E-277 T 17-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 Pfam PF01175 Urocanase 7 541 7.1E-252 T 17-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 SUPERFAMILY SSF111326 4 549 2.49E-246 T 17-03-2017 IPR023637 Urocanase GO:0016153 KEGG: 00340+4.2.1.49|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 Gene3D G3DSA:3.40.1770.10 354 548 6.2E-152 T 17-03-2017 SHXM_RS24390 cb6bf621f9386deff74f64098602e3d5 552 Gene3D G3DSA:3.40.1770.10 6 136 6.2E-152 T 17-03-2017 SHXM_RS11415 c1470369f0f449a241c9a7a0d4f29f18 250 Pfam PF02754 Cysteine-rich domain 138 222 5.4E-16 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS11415 c1470369f0f449a241c9a7a0d4f29f18 250 Pfam PF02754 Cysteine-rich domain 3 83 2.3E-15 T 17-03-2017 IPR004017 Cysteine-rich domain SHXM_RS46465 17d0663b355bb55f0c6fc98a368abdf3 359 Pfam PF13416 Bacterial extracellular solute-binding protein 62 320 9.6E-32 T 17-03-2017 SHXM_RS46465 17d0663b355bb55f0c6fc98a368abdf3 359 SUPERFAMILY SSF53850 39 354 1.13E-64 T 17-03-2017 SHXM_RS46465 17d0663b355bb55f0c6fc98a368abdf3 359 Gene3D G3DSA:3.40.190.10 13 140 2.5E-26 T 17-03-2017 SHXM_RS46465 17d0663b355bb55f0c6fc98a368abdf3 359 Gene3D G3DSA:3.40.190.10 285 349 2.5E-26 T 17-03-2017 SHXM_RS46465 17d0663b355bb55f0c6fc98a368abdf3 359 Gene3D G3DSA:3.40.190.10 143 284 2.1E-26 T 17-03-2017 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 Gene3D G3DSA:3.30.300.30 366 457 2.5E-29 T 17-03-2017 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 Gene3D G3DSA:3.40.50.980 142 290 1.6E-29 T 17-03-2017 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 Gene3D G3DSA:3.40.50.980 21 141 1.8E-20 T 17-03-2017 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 Gene3D G3DSA:2.30.38.10 292 362 9.9E-23 T 17-03-2017 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 Pfam PF13193 AMP-binding enzyme C-terminal domain 378 450 3.8E-20 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 SUPERFAMILY SSF56801 19 457 6.67E-116 T 17-03-2017 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 Pfam PF00501 AMP-binding enzyme 23 369 1.4E-68 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS24465 df87e6559db3244dbc93ef93fcdd9076 459 ProSitePatterns PS00455 Putative AMP-binding domain signature. 133 144 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 Gene3D G3DSA:1.10.260.40 16 84 9.9E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 Pfam PF01381 Helix-turn-helix 19 73 3.4E-15 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 SUPERFAMILY SSF51182 25 181 9.7E-15 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 Gene3D G3DSA:2.60.120.10 91 178 2.7E-14 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 SMART SM00530 18 73 3.2E-17 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 SUPERFAMILY SSF47413 14 77 9.57E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49320 be6200b032d7fb5c80c7d68b7688062e 204 Pfam PF07883 Cupin domain 114 175 1.0E-8 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS09580 f8ee5d0d4cebd3bf60d874c272e604cd 153 Pfam PF13358 DDE superfamily endonuclease 12 109 4.0E-16 T 17-03-2017 SHXM_RS09580 f8ee5d0d4cebd3bf60d874c272e604cd 153 Gene3D G3DSA:3.30.420.10 8 131 2.9E-5 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09580 f8ee5d0d4cebd3bf60d874c272e604cd 153 SUPERFAMILY SSF53098 9 135 2.47E-9 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS05685 cbc219b5892d5d15634d306641b0b5a5 129 SUPERFAMILY SSF57716 96 126 1.43E-6 T 17-03-2017 SHXM_RS05685 cbc219b5892d5d15634d306641b0b5a5 129 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 96 126 2.9E-10 T 17-03-2017 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 SHXM_RS11425 cf907d9638f5dddc7dc11b8cab482e18 219 Pfam PF02589 Uncharacterised ACR, YkgG family COG1556 115 206 4.5E-16 T 17-03-2017 IPR003741 LUD domain SHXM_RS11425 cf907d9638f5dddc7dc11b8cab482e18 219 Gene3D G3DSA:3.40.50.10420 34 206 1.5E-52 T 17-03-2017 IPR024185 5-formyltetrahydrofolate cyclo-ligase-like domain SHXM_RS11425 cf907d9638f5dddc7dc11b8cab482e18 219 SUPERFAMILY SSF100950 36 206 1.55E-36 T 17-03-2017 SHXM_RS09685 3826fd71cd0a97f9d452427960b65bac 389 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 186 288 6.7E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS09685 3826fd71cd0a97f9d452427960b65bac 389 SUPERFAMILY SSF55874 174 287 2.36E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS09685 3826fd71cd0a97f9d452427960b65bac 389 Gene3D G3DSA:3.30.565.10 184 290 5.7E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40455 ac7eb8a41a7ef97b4034c57e507bad56 330 SUPERFAMILY SSF51679 12 328 5.23E-47 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS40455 ac7eb8a41a7ef97b4034c57e507bad56 330 Pfam PF00296 Luciferase-like monooxygenase 19 304 9.6E-42 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS40455 ac7eb8a41a7ef97b4034c57e507bad56 330 Gene3D G3DSA:3.20.20.30 12 326 2.0E-52 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS44175 cc751e3f2647676811364f90494efd30 151 Gene3D G3DSA:3.10.129.10 12 149 1.0E-35 T 17-03-2017 IPR029069 HotDog domain SHXM_RS44175 cc751e3f2647676811364f90494efd30 151 SUPERFAMILY SSF54637 11 145 7.07E-30 T 17-03-2017 IPR029069 HotDog domain SHXM_RS44175 cc751e3f2647676811364f90494efd30 151 Pfam PF03061 Thioesterase superfamily 57 126 1.9E-11 T 17-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 SHXM_RS44175 cc751e3f2647676811364f90494efd30 151 TIGRFAM TIGR00369 unchar_dom_1: uncharacterized domain 1 27 143 8.1E-20 T 17-03-2017 IPR003736 Phenylacetic acid degradation-related domain Reactome: R-HSA-75105 SHXM_RS49015 4adae68bdb6d0550eedceaf574ece3f8 453 ProSitePatterns PS00217 Sugar transport proteins signature 2. 132 157 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS49015 4adae68bdb6d0550eedceaf574ece3f8 453 Pfam PF00083 Sugar (and other) transporter 70 451 2.3E-36 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS49015 4adae68bdb6d0550eedceaf574ece3f8 453 Gene3D G3DSA:1.20.1250.20 28 216 3.1E-30 T 17-03-2017 SHXM_RS49015 4adae68bdb6d0550eedceaf574ece3f8 453 Gene3D G3DSA:1.20.1250.20 263 450 3.2E-19 T 17-03-2017 SHXM_RS49015 4adae68bdb6d0550eedceaf574ece3f8 453 ProSitePatterns PS00216 Sugar transport proteins signature 1. 90 106 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS49015 4adae68bdb6d0550eedceaf574ece3f8 453 SUPERFAMILY SSF103473 16 452 5.23E-71 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS45180 da2b352866bf403ef3f01dcf47381b29 238 Pfam PF03734 L,D-transpeptidase catalytic domain 75 229 1.6E-6 T 17-03-2017 IPR005490 L,D-transpeptidase catalytic domain GO:0016740 SHXM_RS12815 952b04dba44ee23d19f6599874ec15a3 262 Gene3D G3DSA:1.10.3720.10 7 211 7.5E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12815 952b04dba44ee23d19f6599874ec15a3 262 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 32 216 1.7E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12815 952b04dba44ee23d19f6599874ec15a3 262 SUPERFAMILY SSF161098 8 202 1.07E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS16800 48c1d9957e63c25d011a6f2d82cadd1c 193 Pfam PF05685 Putative restriction endonuclease 15 184 6.8E-28 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS16800 48c1d9957e63c25d011a6f2d82cadd1c 193 Gene3D G3DSA:3.90.1570.10 9 164 3.6E-15 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS16800 48c1d9957e63c25d011a6f2d82cadd1c 193 SUPERFAMILY SSF52980 24 174 6.43E-19 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 TIGRFAM TIGR00331 hrcA: heat-inducible transcription repressor HrcA 3 334 2.0E-102 T 17-03-2017 IPR002571 Heat-inducible transcription repressor HrcA GO:0003677|GO:0006355 SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 Gene3D G3DSA:1.10.10.10 2 84 1.2E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 Hamap MF_00081 Heat-inducible transcription repressor HrcA [hrcA]. 1 328 28.618 T 17-03-2017 IPR002571 Heat-inducible transcription repressor HrcA GO:0003677|GO:0006355 SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 PIRSF PIRSF005485 1 338 7.3E-102 T 17-03-2017 IPR002571 Heat-inducible transcription repressor HrcA GO:0003677|GO:0006355 SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 SUPERFAMILY SSF55781 71 336 8.44E-57 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 Gene3D G3DSA:3.30.450.40 176 337 1.9E-43 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 Pfam PF01628 HrcA protein C terminal domain 103 321 3.6E-63 T 17-03-2017 IPR021153 Heat-inducible transcription repressor HrcA, C-terminal GO:0003677|GO:0006355 SHXM_RS21295 609c97c072b96966f2a5e4c486703e1d 338 SUPERFAMILY SSF46785 2 82 1.18E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48665 96ffba985aa67203c24eea808e4a8387 303 Gene3D G3DSA:3.40.190.10 251 286 6.5E-27 T 17-03-2017 SHXM_RS48665 96ffba985aa67203c24eea808e4a8387 303 Gene3D G3DSA:3.40.190.10 58 139 6.5E-27 T 17-03-2017 SHXM_RS48665 96ffba985aa67203c24eea808e4a8387 303 SUPERFAMILY SSF53850 15 287 6.47E-46 T 17-03-2017 SHXM_RS48665 96ffba985aa67203c24eea808e4a8387 303 Gene3D G3DSA:3.40.190.10 140 250 4.4E-14 T 17-03-2017 SHXM_RS48665 96ffba985aa67203c24eea808e4a8387 303 SMART SM00062 61 289 6.7E-23 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS48665 96ffba985aa67203c24eea808e4a8387 303 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 63 286 2.1E-44 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 SUPERFAMILY SSF52172 1 135 1.15E-30 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 Pfam PF00196 Bacterial regulatory proteins, luxR family 154 209 9.6E-18 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 Gene3D G3DSA:3.40.50.2300 1 125 8.1E-33 T 17-03-2017 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 Pfam PF00072 Response regulator receiver domain 5 119 2.9E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 ProSitePatterns PS00622 LuxR-type HTH domain signature. 169 196 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 SMART SM00448 3 118 3.7E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 Gene3D G3DSA:1.10.10.10 126 213 1.6E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 SMART SM00421 152 209 9.2E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 185 197 5.8E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 169 5.8E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 169 185 5.8E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05565 978c7f0364589251fd9aa802eb6e9ce6 216 SUPERFAMILY SSF46894 144 213 2.86E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS12990 5cd25c4f2310cb2fde6b93de6a588dad 384 Pfam PF01960 ArgJ family 11 384 1.4E-127 T 17-03-2017 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS12990 5cd25c4f2310cb2fde6b93de6a588dad 384 TIGRFAM TIGR00120 ArgJ: glutamate N-acetyltransferase/amino-acid acetyltransferase 2 383 6.1E-104 T 17-03-2017 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS12990 5cd25c4f2310cb2fde6b93de6a588dad 384 SUPERFAMILY SSF56266 7 380 3.01E-126 T 17-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS12990 5cd25c4f2310cb2fde6b93de6a588dad 384 Gene3D G3DSA:3.60.70.12 2 260 1.2E-92 T 17-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS12990 5cd25c4f2310cb2fde6b93de6a588dad 384 ProDom PD004193 ACETYLTRANSFERASE ORNITHINE ARGININE BIOSYNTHESIS ARGJ GLUTAMATE N-ACETYLTRANSFERASE TRANSFERASE ACYLTRANSFERASE BIFUNCTIONAL 17 382 3.0E-179 T 17-03-2017 SHXM_RS12990 5cd25c4f2310cb2fde6b93de6a588dad 384 Hamap MF_01106 Arginine biosynthesis bifunctional protein ArgJ [argJ]. 1 384 132.023 T 17-03-2017 IPR002813 Arginine biosynthesis protein ArgJ GO:0004358|GO:0006526 KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS15445 2ea08ea92ec85513c99966d1a572f4db 83 SUPERFAMILY SSF47336 6 78 3.14E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS15445 2ea08ea92ec85513c99966d1a572f4db 83 Pfam PF00550 Phosphopantetheine attachment site 10 75 2.9E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS15445 2ea08ea92ec85513c99966d1a572f4db 83 Gene3D G3DSA:1.10.1200.10 8 78 5.7E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 Gene3D G3DSA:2.30.40.10 459 524 1.1E-9 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 Gene3D G3DSA:3.20.20.140 73 293 6.2E-112 T 17-03-2017 SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 Gene3D G3DSA:3.20.20.140 398 458 6.2E-112 T 17-03-2017 SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 SUPERFAMILY SSF51338 474 525 6.42E-23 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 SUPERFAMILY SSF51338 1 59 6.42E-23 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 Gene3D G3DSA:2.30.40.10 1 72 2.5E-18 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 SUPERFAMILY SSF51556 344 474 2.69E-71 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 SUPERFAMILY SSF51556 59 301 2.69E-71 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS33355 041b320ead821e6c4cb52b880de6d11f 536 Pfam PF07969 Amidohydrolase family 47 519 2.4E-65 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS11760 6b55473f164771eb59b3c15883f6c7f8 341 Pfam PF00248 Aldo/keto reductase family 20 308 3.4E-67 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS11760 6b55473f164771eb59b3c15883f6c7f8 341 SUPERFAMILY SSF51430 14 311 2.23E-83 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS11760 6b55473f164771eb59b3c15883f6c7f8 341 Gene3D G3DSA:3.20.20.100 14 321 8.6E-93 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS02325 46c401eda945bbf473ef9e4cfd412139 388 Gene3D G3DSA:3.20.20.10 29 244 4.0E-12 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS02325 46c401eda945bbf473ef9e4cfd412139 388 Pfam PF01168 Alanine racemase, N-terminal domain 24 246 6.1E-24 T 17-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS02325 46c401eda945bbf473ef9e4cfd412139 388 SMART SM01119 262 367 4.2E-36 T 17-03-2017 IPR026956 D-serine dehydratase-like domain SHXM_RS02325 46c401eda945bbf473ef9e4cfd412139 388 SUPERFAMILY SSF51419 26 245 5.07E-25 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS02325 46c401eda945bbf473ef9e4cfd412139 388 Pfam PF14031 Putative serine dehydratase domain 262 366 3.9E-19 T 17-03-2017 IPR026956 D-serine dehydratase-like domain SHXM_RS16840 2d623701b97a7909d7e9fba45a1b7694 416 SUPERFAMILY SSF56059 96 326 1.02E-26 T 17-03-2017 SHXM_RS16840 2d623701b97a7909d7e9fba45a1b7694 416 Gene3D G3DSA:3.30.470.20 106 332 5.7E-17 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS16840 2d623701b97a7909d7e9fba45a1b7694 416 Pfam PF13535 ATP-grasp domain 161 299 5.5E-9 T 17-03-2017 SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 SUPERFAMILY SSF46785 2 70 1.39E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 SUPERFAMILY SSF55781 62 236 4.19E-47 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 Gene3D G3DSA:3.30.450.40 67 236 7.1E-52 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 Pfam PF01614 Bacterial transcriptional regulator 115 234 3.0E-26 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 SMART SM00346 2 87 4.1E-21 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 Gene3D G3DSA:1.10.10.10 2 66 4.4E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37305 ae9ca029c8ce3fceb2bff3eb671aab64 240 Pfam PF09339 IclR helix-turn-helix domain 2 51 6.6E-17 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 SMART SM01120 395 571 3.3E-51 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 Gene3D G3DSA:3.30.1180.20 183 332 5.4E-46 T 17-03-2017 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 SUPERFAMILY SSF82549 11 331 2.43E-99 T 17-03-2017 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 Gene3D G3DSA:3.40.50.10440 12 180 4.0E-53 T 17-03-2017 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 SUPERFAMILY SSF101473 370 571 1.23E-42 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 Pfam PF02733 Dak1 domain 18 328 1.9E-103 T 17-03-2017 IPR004006 DhaK domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS41610 1532c3e30c4819ff5c6774d8d75b3ec2 581 Pfam PF02734 DAK2 domain 396 570 9.2E-44 T 17-03-2017 IPR004007 DhaL domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS15955 538533deb2b7cac276b510867decfc95 314 Pfam PF12705 PD-(D/E)XK nuclease superfamily 41 292 8.8E-37 T 17-03-2017 SHXM_RS15955 538533deb2b7cac276b510867decfc95 314 SUPERFAMILY SSF52980 67 227 9.12E-9 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS39105 410ae10c824c732d192e34a542e40c66 384 TIGRFAM TIGR00744 ROK_glcA_fam: ROK family protein (putative glucokinase) 38 347 3.6E-92 T 17-03-2017 IPR004654 Glucokinase ROK GO:0004340|GO:0005737|GO:0006096|GO:0051156 KEGG: 00010+2.7.1.2|KEGG: 00052+2.7.1.2|KEGG: 00500+2.7.1.2|KEGG: 00520+2.7.1.2|KEGG: 00521+2.7.1.2|KEGG: 00524+2.7.1.2|MetaCyc: PWY-2722|MetaCyc: PWY-2723|MetaCyc: PWY-5514|MetaCyc: PWY-5661|MetaCyc: PWY-621|MetaCyc: PWY-7238|MetaCyc: PWY-7385 SHXM_RS39105 410ae10c824c732d192e34a542e40c66 384 Gene3D G3DSA:3.30.420.40 172 320 9.6E-51 T 17-03-2017 SHXM_RS39105 410ae10c824c732d192e34a542e40c66 384 Gene3D G3DSA:3.30.420.40 37 171 7.7E-46 T 17-03-2017 SHXM_RS39105 410ae10c824c732d192e34a542e40c66 384 ProSitePatterns PS01125 ROK family signature. 166 193 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS39105 410ae10c824c732d192e34a542e40c66 384 Pfam PF00480 ROK family 37 347 9.4E-81 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS39105 410ae10c824c732d192e34a542e40c66 384 SUPERFAMILY SSF53067 37 348 2.39E-70 T 17-03-2017 SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 Pfam PF08448 PAS fold 12 135 5.9E-11 T 17-03-2017 IPR013656 PAS fold-4 SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 SMART SM00091 6 72 0.0074 T 17-03-2017 IPR000014 PAS domain SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 SUPERFAMILY SSF81606 173 368 4.45E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 SMART SM00331 158 371 1.0E-28 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 SUPERFAMILY SSF55785 6 122 2.62E-9 T 17-03-2017 IPR000014 PAS domain SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 184 368 4.4E-42 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS23620 739dff6e73446e6569aedd73a58f41dd 371 Gene3D G3DSA:3.30.450.20 2 133 1.3E-12 T 17-03-2017 SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 Gene3D G3DSA:1.10.1660.10 58 115 2.1E-5 T 17-03-2017 SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 SMART SM00871 119 272 2.7E-12 T 17-03-2017 IPR010499 Bacterial transcription activator, effector binding SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 Pfam PF06445 GyrI-like small molecule binding domain 122 271 7.2E-12 T 17-03-2017 IPR029442 GyrI-like small molecule binding domain SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 SMART SM00422 2 72 7.0E-17 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 Pfam PF13411 MerR HTH family regulatory protein 2 71 9.9E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 Gene3D G3DSA:3.20.80.10 194 271 2.1E-5 T 17-03-2017 IPR011256 Regulatory factor, effector binding domain SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 SUPERFAMILY SSF55136 120 272 2.96E-19 T 17-03-2017 IPR011256 Regulatory factor, effector binding domain SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 SUPERFAMILY SSF46955 2 100 3.41E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS05035 32cd891fbbb50a8f4d282e9bf1d6b49c 274 Gene3D G3DSA:1.10.1660.10 1 57 1.8E-22 T 17-03-2017 SHXM_RS22080 57bc8cf2c0dfaf704fd4f97f02c9012f 168 Pfam PF02537 CrcB-like protein, Camphor Resistance (CrcB) 37 146 2.4E-21 T 17-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 SHXM_RS22080 57bc8cf2c0dfaf704fd4f97f02c9012f 168 TIGRFAM TIGR00494 crcB: protein CrcB 38 148 2.2E-24 T 17-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 SHXM_RS22080 57bc8cf2c0dfaf704fd4f97f02c9012f 168 Hamap MF_00454 Putative fluoride ion transporter CrcB [crcB]. 35 152 18.324 T 17-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 SHXM_RS00040 e3887133e902ab5f6393880c41e0b161 263 Pfam PF13649 Methyltransferase domain 40 137 8.0E-14 T 17-03-2017 SHXM_RS00040 e3887133e902ab5f6393880c41e0b161 263 Gene3D G3DSA:3.40.50.150 181 198 2.2E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00040 e3887133e902ab5f6393880c41e0b161 263 Gene3D G3DSA:3.40.50.150 13 147 2.2E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00040 e3887133e902ab5f6393880c41e0b161 263 SUPERFAMILY SSF53335 8 204 7.02E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10190 e3887133e902ab5f6393880c41e0b161 263 Pfam PF13649 Methyltransferase domain 40 137 8.0E-14 T 17-03-2017 SHXM_RS10190 e3887133e902ab5f6393880c41e0b161 263 Gene3D G3DSA:3.40.50.150 181 198 2.2E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10190 e3887133e902ab5f6393880c41e0b161 263 Gene3D G3DSA:3.40.50.150 13 147 2.2E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10190 e3887133e902ab5f6393880c41e0b161 263 SUPERFAMILY SSF53335 8 204 7.02E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18920 8b9d56f1d3583468a3b6b7f70db8dc88 324 Pfam PF00294 pfkB family carbohydrate kinase 32 295 7.6E-40 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS18920 8b9d56f1d3583468a3b6b7f70db8dc88 324 Gene3D G3DSA:3.40.1190.20 2 307 1.6E-46 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS18920 8b9d56f1d3583468a3b6b7f70db8dc88 324 SUPERFAMILY SSF53613 2 295 1.87E-53 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS27280 fb32e054346f00990282bddd61605099 316 Gene3D G3DSA:3.30.2010.10 117 189 5.0E-18 T 17-03-2017 SHXM_RS27280 fb32e054346f00990282bddd61605099 316 Pfam PF01435 Peptidase family M48 119 192 1.2E-10 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS02560 cfee2c96b493f6e9e133f944e868d7e6 395 SUPERFAMILY SSF56059 128 306 4.24E-16 T 17-03-2017 SHXM_RS02560 cfee2c96b493f6e9e133f944e868d7e6 395 Gene3D G3DSA:3.30.470.20 130 309 3.3E-11 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS22870 3c9cb076adb20580f0d6d94119c48520 213 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 16 97 1.2E-5 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 Gene3D G3DSA:1.10.10.10 8 78 1.4E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 Gene3D G3DSA:3.30.420.40 224 336 1.6E-23 T 17-03-2017 SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 SUPERFAMILY SSF53067 84 362 3.24E-41 T 17-03-2017 SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 Pfam PF00480 ROK family 264 358 1.5E-9 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 Pfam PF00480 ROK family 87 245 2.0E-21 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 Pfam PF09339 IclR helix-turn-helix domain 15 58 1.8E-5 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 Gene3D G3DSA:3.30.420.40 82 223 3.7E-28 T 17-03-2017 SHXM_RS48335 ec5dd81a1adf947eddf1bb640220efe9 369 SUPERFAMILY SSF46785 9 78 3.71E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07735 21d9f09bcf44ef9bbca5a146ca04b4e3 302 SUPERFAMILY SSF161098 63 290 2.88E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07735 21d9f09bcf44ef9bbca5a146ca04b4e3 302 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 94 292 8.1E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07735 21d9f09bcf44ef9bbca5a146ca04b4e3 302 Gene3D G3DSA:1.10.3720.10 16 293 1.2E-61 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 SUPERFAMILY SSF50118 3 76 2.22E-22 T 17-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 Gene3D G3DSA:3.40.109.10 316 409 2.1E-24 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 Gene3D G3DSA:3.40.109.10 86 155 2.1E-24 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 SUPERFAMILY SSF55469 197 258 3.93E-5 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 SUPERFAMILY SSF55469 318 408 3.93E-5 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 Pfam PF08940 Domain of unknown function (DUF1918) 3 60 1.2E-25 T 17-03-2017 IPR015035 Domain of unknown function DUF1918 SHXM_RS43495 87ed1beebbf45a7abb828a617384c586 412 SUPERFAMILY SSF55469 82 172 1.44E-9 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS46545 d74e5d5a6217e7b2911be151226d9d50 346 ProDom PD017907 3-DEHYDROQUINATE UPF0245 SYNTHASE LYASE PREDICTED SYNTHASE-LIKE ALTERNATIVE T19N8 MM1272 MK1408 102 345 2.0E-78 T 17-03-2017 IPR002812 3-dehydroquinate synthase GO:0003856|GO:0009073|GO:0016491|GO:0055114 KEGG: 00400+1.4.1.24|MetaCyc: PWY-6160 SHXM_RS46545 d74e5d5a6217e7b2911be151226d9d50 346 Pfam PF01959 3-dehydroquinate synthase (EC 4.6.1.3) 2 345 1.2E-105 T 17-03-2017 IPR002812 3-dehydroquinate synthase GO:0003856|GO:0009073|GO:0016491|GO:0055114 KEGG: 00400+1.4.1.24|MetaCyc: PWY-6160 SHXM_RS35785 ed66ab4f943b705b8b9edba905251a23 517 SUPERFAMILY SSF53850 235 510 1.69E-54 T 17-03-2017 SHXM_RS35785 ed66ab4f943b705b8b9edba905251a23 517 Pfam PF12849 PBP superfamily domain 230 487 2.6E-29 T 17-03-2017 IPR024370 PBP domain SHXM_RS35785 ed66ab4f943b705b8b9edba905251a23 517 Gene3D G3DSA:3.40.190.10 331 460 8.7E-34 T 17-03-2017 SHXM_RS35785 ed66ab4f943b705b8b9edba905251a23 517 Gene3D G3DSA:3.40.190.10 232 330 5.2E-4 T 17-03-2017 SHXM_RS40710 e686b2bb42aaac8dad59ec8751815db8 220 PIRSF PIRSF016897 14 202 1.0E-42 T 17-03-2017 IPR006699 Glycerol-3-phosphate responsive antiterminator GO:0006355|GO:0009607 SHXM_RS40710 e686b2bb42aaac8dad59ec8751815db8 220 SUPERFAMILY SSF110391 24 197 1.7E-37 T 17-03-2017 IPR006699 Glycerol-3-phosphate responsive antiterminator GO:0006355|GO:0009607 SHXM_RS40710 e686b2bb42aaac8dad59ec8751815db8 220 Pfam PF04309 Glycerol-3-phosphate responsive antiterminator 25 196 1.4E-39 T 17-03-2017 IPR006699 Glycerol-3-phosphate responsive antiterminator GO:0006355|GO:0009607 SHXM_RS40710 e686b2bb42aaac8dad59ec8751815db8 220 Gene3D G3DSA:3.20.20.400 16 200 2.9E-48 T 17-03-2017 IPR006699 Glycerol-3-phosphate responsive antiterminator GO:0006355|GO:0009607 SHXM_RS39355 b61ac390e2eb9ec8f554c67a8896f255 75 Gene3D G3DSA:3.30.360.10 6 62 5.9E-10 T 17-03-2017 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 SUPERFAMILY SSF46894 4 90 1.87E-7 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 SMART SM00862 16 90 4.3E-10 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 Pfam PF03704 Bacterial transcriptional activator domain 99 241 5.4E-40 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 SMART SM01043 99 241 2.5E-47 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 SUPERFAMILY SSF52540 357 630 1.3E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 PRINTS PR00364 Disease resistance protein signature 468 482 5.7E-5 T 17-03-2017 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 PRINTS PR00364 Disease resistance protein signature 385 400 5.7E-5 T 17-03-2017 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 PRINTS PR00364 Disease resistance protein signature 564 578 5.7E-5 T 17-03-2017 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 SUPERFAMILY SSF48452 96 251 3.16E-31 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 Gene3D G3DSA:1.10.10.10 17 91 6.2E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 Gene3D G3DSA:1.25.40.10 1032 1265 5.7E-12 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 SUPERFAMILY SSF48452 1029 1154 2.94E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS29815 8014a1748c851c3809130307f317e38f 1313 Pfam PF00486 Transcriptional regulatory protein, C terminal 24 79 1.1E-4 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS01060 dbd87b90adcfa64f4df921276da90bfc 152 SMART SM00347 34 132 1.0E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01060 dbd87b90adcfa64f4df921276da90bfc 152 SUPERFAMILY SSF46785 13 128 3.74E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01060 dbd87b90adcfa64f4df921276da90bfc 152 Gene3D G3DSA:1.10.10.10 11 127 1.8E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01060 dbd87b90adcfa64f4df921276da90bfc 152 Pfam PF01047 MarR family 42 96 5.8E-12 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 Gene3D G3DSA:1.10.10.10 3 83 1.1E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 Pfam PF00891 O-methyltransferase 100 320 2.8E-41 T 17-03-2017 IPR001077 O-methyltransferase, family 2 GO:0008171 SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 PIRSF PIRSF005739 6 334 7.6E-32 T 17-03-2017 IPR016461 O-methyltransferase COMT-type GO:0008168 SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 Gene3D G3DSA:3.40.50.150 92 333 1.6E-55 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 SUPERFAMILY SSF53335 92 332 1.86E-46 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 SUPERFAMILY SSF46785 9 86 1.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02920 9659c1230aaf28834039824e13d7ee48 336 Pfam PF16864 Dimerisation domain 10 89 2.1E-17 T 17-03-2017 IPR031725 Acetylserotonin O-methyltransferase, dimerisation domain SHXM_RS35560 f8beb660ee61b8601f24efa101ff5b01 710 Gene3D G3DSA:3.90.550.10 345 576 8.6E-54 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS35560 f8beb660ee61b8601f24efa101ff5b01 710 SUPERFAMILY SSF53448 342 599 4.79E-64 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS35560 f8beb660ee61b8601f24efa101ff5b01 710 Gene3D G3DSA:3.20.20.370 36 225 8.3E-32 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS35560 f8beb660ee61b8601f24efa101ff5b01 710 Pfam PF13641 Glycosyltransferase like family 2 345 564 3.5E-37 T 17-03-2017 SHXM_RS35560 f8beb660ee61b8601f24efa101ff5b01 710 SUPERFAMILY SSF88713 86 223 6.12E-31 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS35560 f8beb660ee61b8601f24efa101ff5b01 710 Pfam PF01522 Polysaccharide deacetylase 93 194 9.8E-21 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS00765 19f8e80da3b710faabd502847314407e 221 SUPERFAMILY SSF55469 2 84 3.01E-40 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS00765 19f8e80da3b710faabd502847314407e 221 SUPERFAMILY SSF55469 123 218 3.01E-40 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS00765 19f8e80da3b710faabd502847314407e 221 Pfam PF00881 Nitroreductase family 8 196 2.1E-27 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS00765 19f8e80da3b710faabd502847314407e 221 Gene3D G3DSA:3.40.109.10 123 219 6.1E-41 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS00765 19f8e80da3b710faabd502847314407e 221 Gene3D G3DSA:3.40.109.10 2 91 6.1E-41 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS35035 2987385d8e709a19e149ba1fd0459f9f 309 Gene3D G3DSA:1.10.260.40 29 90 2.4E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35035 2987385d8e709a19e149ba1fd0459f9f 309 SUPERFAMILY SSF47413 28 90 2.94E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35035 2987385d8e709a19e149ba1fd0459f9f 309 Pfam PF13560 Helix-turn-helix domain 33 95 2.2E-13 T 17-03-2017 SHXM_RS35035 2987385d8e709a19e149ba1fd0459f9f 309 SMART SM00530 36 92 2.1E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49050 6cecf2faf96642fd9000a558628360ff 321 Gene3D G3DSA:1.10.10.60 196 251 2.4E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49050 6cecf2faf96642fd9000a558628360ff 321 SUPERFAMILY SSF46689 198 247 2.78E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49050 6cecf2faf96642fd9000a558628360ff 321 Pfam PF12833 Helix-turn-helix domain 219 282 1.1E-12 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS49050 6cecf2faf96642fd9000a558628360ff 321 SMART SM00342 213 289 1.0E-9 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS49050 6cecf2faf96642fd9000a558628360ff 321 Pfam PF06719 AraC-type transcriptional regulator N-terminus 40 185 9.3E-25 T 17-03-2017 IPR009594 Transcription regulator HTH, AraC, N-terminal SHXM_RS22925 031426f3f4b3c73501c735fb04ba8eff 547 Gene3D G3DSA:2.30.38.10 338 410 8.3E-15 T 17-03-2017 SHXM_RS22925 031426f3f4b3c73501c735fb04ba8eff 547 Gene3D G3DSA:3.30.300.30 414 521 5.5E-7 T 17-03-2017 SHXM_RS22925 031426f3f4b3c73501c735fb04ba8eff 547 SUPERFAMILY SSF56801 5 524 6.15E-76 T 17-03-2017 SHXM_RS22925 031426f3f4b3c73501c735fb04ba8eff 547 Gene3D G3DSA:3.40.50.980 173 333 7.4E-19 T 17-03-2017 SHXM_RS22925 031426f3f4b3c73501c735fb04ba8eff 547 Pfam PF00501 AMP-binding enzyme 12 420 2.0E-58 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS22925 031426f3f4b3c73501c735fb04ba8eff 547 Gene3D G3DSA:3.40.50.980 6 172 5.6E-22 T 17-03-2017 SHXM_RS08525 3e9a395c734b5f6b7399205a68ef4d47 78 Pfam PF04149 Domain of unknown function (DUF397) 10 62 1.2E-18 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 ProSitePatterns PS00560 Serine carboxypeptidases, histidine active site. 261 278 - T 17-03-2017 IPR033124 Serine carboxypeptidases, histidine active site Reactome: R-HSA-1660662|Reactome: R-HSA-2132295|Reactome: R-HSA-4085001 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00412 Epoxide hydrolase signature 58 73 2.3E-21 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00412 Epoxide hydrolase signature 103 116 2.3E-21 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00412 Epoxide hydrolase signature 266 288 2.3E-21 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00412 Epoxide hydrolase signature 38 56 2.3E-21 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00412 Epoxide hydrolase signature 117 130 2.3E-21 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00111 Alpha/beta hydrolase fold signature 117 130 5.5E-11 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00111 Alpha/beta hydrolase fold signature 103 116 5.5E-11 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 PRINTS PR00111 Alpha/beta hydrolase fold signature 58 73 5.5E-11 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 SUPERFAMILY SSF53474 9 290 8.32E-73 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 Gene3D G3DSA:3.40.50.1820 7 289 1.1E-70 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40250 c81559f09c64c4a6a2b4ee2178d4e746 299 Pfam PF00561 alpha/beta hydrolase fold 33 273 1.6E-26 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS30805 cf753ee17ede211d975fc55caaa33f3c 99 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 6 93 3.6E-23 T 17-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SHXM_RS30805 cf753ee17ede211d975fc55caaa33f3c 99 Hamap MF_01456 NAD(P)H-quinone oxidoreductase subunit 4L, chloroplastic [ndhE]. 1 99 19.469 T 17-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SHXM_RS07415 291a13419af104677ee033e05c2c9b21 445 Gene3D G3DSA:1.20.1250.20 15 215 8.1E-22 T 17-03-2017 SHXM_RS07415 291a13419af104677ee033e05c2c9b21 445 Gene3D G3DSA:1.20.1250.20 237 423 3.8E-25 T 17-03-2017 SHXM_RS07415 291a13419af104677ee033e05c2c9b21 445 ProSitePatterns PS00217 Sugar transport proteins signature 2. 126 151 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS07415 291a13419af104677ee033e05c2c9b21 445 SUPERFAMILY SSF103473 13 421 6.93E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS07415 291a13419af104677ee033e05c2c9b21 445 Pfam PF07690 Major Facilitator Superfamily 50 371 8.5E-26 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS31050 32fcd1374ffb4bc0cb9ea30f8b41fe04 145 Pfam PF01575 MaoC like domain 19 110 3.3E-24 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS31050 32fcd1374ffb4bc0cb9ea30f8b41fe04 145 SUPERFAMILY SSF54637 1 142 5.6E-29 T 17-03-2017 IPR029069 HotDog domain SHXM_RS31050 32fcd1374ffb4bc0cb9ea30f8b41fe04 145 Gene3D G3DSA:3.10.129.10 9 144 3.3E-38 T 17-03-2017 IPR029069 HotDog domain SHXM_RS31050 32fcd1374ffb4bc0cb9ea30f8b41fe04 145 PRINTS PR01483 Fatty acid synthase signature 26 48 4.8E-7 T 17-03-2017 IPR003965 Fatty acid synthase GO:0004312|GO:0005835|GO:0006633|GO:0055114 SHXM_RS31050 32fcd1374ffb4bc0cb9ea30f8b41fe04 145 PRINTS PR01483 Fatty acid synthase signature 48 69 4.8E-7 T 17-03-2017 IPR003965 Fatty acid synthase GO:0004312|GO:0005835|GO:0006633|GO:0055114 SHXM_RS49995 6c55d3dc5dd7e1c808b45bb97649e1a1 434 SUPERFAMILY SSF103473 31 415 2.35E-33 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49995 6c55d3dc5dd7e1c808b45bb97649e1a1 434 Pfam PF07690 Major Facilitator Superfamily 33 331 2.8E-16 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS49995 6c55d3dc5dd7e1c808b45bb97649e1a1 434 Gene3D G3DSA:1.20.1250.20 226 412 1.9E-6 T 17-03-2017 SHXM_RS49995 6c55d3dc5dd7e1c808b45bb97649e1a1 434 Gene3D G3DSA:1.20.1250.20 31 205 1.1E-17 T 17-03-2017 SHXM_RS11205 e0618d26a2f6d5c17a73549fcda08217 644 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 35 293 1.5E-12 T 17-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SHXM_RS11205 e0618d26a2f6d5c17a73549fcda08217 644 Gene3D G3DSA:3.20.20.80 3 333 4.2E-40 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS11205 e0618d26a2f6d5c17a73549fcda08217 644 SUPERFAMILY SSF51445 10 332 2.98E-44 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS41920 db4c51425c54fca955f40b7b5914d806 263 Gene3D G3DSA:3.90.850.10 3 262 2.7E-61 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS41920 db4c51425c54fca955f40b7b5914d806 263 SUPERFAMILY SSF56529 2 261 6.93E-54 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS41920 db4c51425c54fca955f40b7b5914d806 263 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 106 262 2.2E-11 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS04835 045153cb75379a45b5dcbe08e3b21805 438 SUPERFAMILY SSF55874 290 404 2.84E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS04835 045153cb75379a45b5dcbe08e3b21805 438 SMART SM00387 305 406 1.8E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS04835 045153cb75379a45b5dcbe08e3b21805 438 Pfam PF07730 Histidine kinase 192 256 4.6E-11 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS04835 045153cb75379a45b5dcbe08e3b21805 438 Gene3D G3DSA:3.30.565.10 300 411 4.9E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS04835 045153cb75379a45b5dcbe08e3b21805 438 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 309 405 3.4E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS32005 f4e62e6217f2a436344d23f68062480a 312 Pfam PF01068 ATP dependent DNA ligase domain 30 203 9.0E-24 T 17-03-2017 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 SHXM_RS32005 f4e62e6217f2a436344d23f68062480a 312 Gene3D G3DSA:3.30.470.30 41 158 9.2E-24 T 17-03-2017 SHXM_RS32005 f4e62e6217f2a436344d23f68062480a 312 SUPERFAMILY SSF56091 28 203 3.84E-39 T 17-03-2017 SHXM_RS32005 f4e62e6217f2a436344d23f68062480a 312 Gene3D G3DSA:3.30.1490.70 10 40 4.8E-11 T 17-03-2017 SHXM_RS32005 f4e62e6217f2a436344d23f68062480a 312 Gene3D G3DSA:3.30.1490.70 165 205 4.8E-11 T 17-03-2017 SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 SUPERFAMILY SSF46785 21 86 9.67E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 SUPERFAMILY SSF53067 96 396 1.03E-36 T 17-03-2017 SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 Gene3D G3DSA:3.30.420.40 233 376 7.0E-32 T 17-03-2017 SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 Pfam PF00480 ROK family 102 363 6.3E-29 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 SMART SM00418 18 99 0.005 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 Gene3D G3DSA:1.10.10.10 20 88 1.2E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 Gene3D G3DSA:3.30.420.40 89 232 2.1E-33 T 17-03-2017 SHXM_RS21910 0149b01f44f08dc69934c95c8bbaf537 411 Pfam PF12802 MarR family 26 71 7.8E-7 T 17-03-2017 SHXM_RS21970 9df6a3969e4b9829122f84647aabad56 383 SMART SM00240 294 354 0.002 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS21970 9df6a3969e4b9829122f84647aabad56 383 SUPERFAMILY SSF49879 227 378 4.97E-22 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS21970 9df6a3969e4b9829122f84647aabad56 383 Gene3D G3DSA:2.60.200.20 208 234 1.2E-19 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS21970 9df6a3969e4b9829122f84647aabad56 383 Gene3D G3DSA:2.60.200.20 272 374 1.2E-19 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS21970 9df6a3969e4b9829122f84647aabad56 383 Pfam PF00498 FHA domain 295 373 1.4E-13 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS48235 26af0cccfc5c6d0b258f7816be321709 340 Pfam PF12833 Helix-turn-helix domain 255 329 4.1E-16 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS48235 26af0cccfc5c6d0b258f7816be321709 340 SUPERFAMILY SSF46689 282 330 9.41E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48235 26af0cccfc5c6d0b258f7816be321709 340 Gene3D G3DSA:1.10.10.60 282 330 2.8E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48235 26af0cccfc5c6d0b258f7816be321709 340 Pfam PF12625 Arabinose-binding domain of AraC transcription regulator, N-term 21 203 1.1E-42 T 17-03-2017 IPR032687 HTH-type transcriptional regulator AraC-type, N-terminal SHXM_RS48235 26af0cccfc5c6d0b258f7816be321709 340 Gene3D G3DSA:1.10.10.10 230 268 8.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48235 26af0cccfc5c6d0b258f7816be321709 340 SMART SM00342 246 328 5.2E-17 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 Pfam PF03176 MMPL family 401 704 6.9E-36 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 Pfam PF03176 MMPL family 75 333 4.7E-42 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 SUPERFAMILY SSF82866 109 332 6.02E-34 T 17-03-2017 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 SUPERFAMILY SSF82866 496 700 5.23E-30 T 17-03-2017 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 Gene3D G3DSA:1.20.1640.10 132 334 2.9E-32 T 17-03-2017 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 Gene3D G3DSA:1.20.1640.10 506 703 1.1E-33 T 17-03-2017 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 PRINTS PR00702 Acriflavin resistance protein family signature 197 218 5.3E-5 T 17-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SHXM_RS19200 ff427313ac3de548af3c81452263dda2 731 PRINTS PR00702 Acriflavin resistance protein family signature 303 326 5.3E-5 T 17-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SHXM_RS26725 bb778d0645bb139d5d1440214c46797f 672 Gene3D G3DSA:3.30.565.10 18 220 2.8E-24 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26725 bb778d0645bb139d5d1440214c46797f 672 SUPERFAMILY SSF55874 18 217 5.8E-23 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26725 bb778d0645bb139d5d1440214c46797f 672 Pfam PF13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 33 150 2.1E-25 T 17-03-2017 SHXM_RS02230 6d5c04c4000ed02c7f90ddde4aa8db1d 302 SUPERFAMILY SSF53335 18 299 4.24E-64 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02230 6d5c04c4000ed02c7f90ddde4aa8db1d 302 Pfam PF04072 Leucine carboxyl methyltransferase 22 202 2.9E-50 T 17-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 SHXM_RS02230 6d5c04c4000ed02c7f90ddde4aa8db1d 302 TIGRFAM TIGR00027 mthyl_TIGR00027: methyltransferase, TIGR00027 family 20 279 2.9E-75 T 17-03-2017 IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative GO:0008168 SHXM_RS02230 6d5c04c4000ed02c7f90ddde4aa8db1d 302 Gene3D G3DSA:3.40.50.150 79 215 7.8E-17 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS39630 574e8252ac993f258e858b9a0b2c0153 356 Pfam PF01761 3-dehydroquinate synthase 61 302 1.1E-79 T 17-03-2017 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS39630 574e8252ac993f258e858b9a0b2c0153 356 Gene3D G3DSA:3.40.50.1970 5 164 4.2E-49 T 17-03-2017 SHXM_RS39630 574e8252ac993f258e858b9a0b2c0153 356 SUPERFAMILY SSF56796 6 332 6.28E-89 T 17-03-2017 SHXM_RS39630 574e8252ac993f258e858b9a0b2c0153 356 Gene3D G3DSA:1.20.1090.10 165 332 6.8E-40 T 17-03-2017 SHXM_RS39630 574e8252ac993f258e858b9a0b2c0153 356 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 3 333 30.886 T 17-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS27590 d40d07884fac8182bc00a1b7fc55a723 156 Gene3D G3DSA:3.10.180.10 7 141 1.1E-7 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS27590 d40d07884fac8182bc00a1b7fc55a723 156 SUPERFAMILY SSF54593 7 142 4.83E-7 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS07340 ca725ba52e9a6e99364eb72ff082548b 247 Pfam PF11575 FhuF 2Fe-2S C-terminal domain 218 238 3.3E-9 T 17-03-2017 IPR024726 Ferric iron reductase, C-terminal GO:0051537 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 TIGRFAM TIGR01224 hutI: imidazolonepropionase 38 396 4.8E-111 T 17-03-2017 IPR005920 Imidazolonepropionase GO:0005737|GO:0016812|GO:0019556 KEGG: 00340+3.5.2.7|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 SUPERFAMILY SSF51556 74 356 2.4E-66 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 Gene3D G3DSA:3.20.20.140 80 342 1.1E-41 T 17-03-2017 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 Gene3D G3DSA:2.30.40.10 37 79 6.2E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 SUPERFAMILY SSF51338 32 75 3.52E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 SUPERFAMILY SSF51338 358 400 3.52E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 Pfam PF01979 Amidohydrolase family 258 376 2.8E-16 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 Hamap MF_00372 Imidazolonepropionase [hutI]. 13 398 42.747 T 17-03-2017 IPR005920 Imidazolonepropionase GO:0005737|GO:0016812|GO:0019556 KEGG: 00340+3.5.2.7|MetaCyc: PWY-5028|MetaCyc: PWY-5030|Reactome: R-HSA-70921 SHXM_RS24375 846a30c32e5349df8be68f3ea03131aa 405 Gene3D G3DSA:2.30.40.10 343 388 2.4E-4 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS40485 ad3f23a173fd62b1f8f683dd5d9be758 252 SUPERFAMILY SSF53335 18 136 1.15E-13 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40485 ad3f23a173fd62b1f8f683dd5d9be758 252 Gene3D G3DSA:3.40.50.150 23 141 2.1E-13 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS40485 ad3f23a173fd62b1f8f683dd5d9be758 252 Pfam PF08241 Methyltransferase domain 44 120 1.0E-8 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 SUPERFAMILY SSF53901 185 336 8.87E-18 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 SUPERFAMILY SSF53901 30 118 8.87E-18 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 Gene3D G3DSA:3.40.47.10 266 380 3.0E-8 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 PIRSF PIRSF000429 8 385 2.0E-18 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 SUPERFAMILY SSF53901 249 379 8.44E-21 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 Gene3D G3DSA:3.40.47.10 202 229 6.0E-11 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS48585 f1afd8ddfa488d40deb0cef77a32b8ed 390 Gene3D G3DSA:3.40.47.10 28 117 6.0E-11 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS04515 b66edd385f682bd455fef104098e6a7a 244 TIGRFAM TIGR03943 TIGR03943: TIGR03943 family protein 23 238 1.2E-45 T 17-03-2017 IPR015402 Protein of unknown function DUF1980 SHXM_RS17795 e43a14ee1c017c59ee86d4ea6e166ae1 106 SUPERFAMILY SSF103481 7 104 2.09E-20 T 17-03-2017 SHXM_RS17795 e43a14ee1c017c59ee86d4ea6e166ae1 106 Pfam PF00893 Small Multidrug Resistance protein 1 93 8.0E-27 T 17-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 Pfam PF00265 Thymidine kinase 4 192 4.1E-24 T 17-03-2017 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-73614 SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 Gene3D G3DSA:3.40.50.300 2 121 6.7E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 Hamap MF_00124 Thymidine kinase [tdk]. 1 195 28.295 T 17-03-2017 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-73614 SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 SUPERFAMILY SSF57716 144 195 1.43E-8 T 17-03-2017 SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 SUPERFAMILY SSF52540 1 139 1.58E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 PIRSF PIRSF035805 1 202 3.4E-36 T 17-03-2017 IPR001267 Thymidine kinase GO:0004797|GO:0005524 KEGG: 00240+2.7.1.21|KEGG: 00983+2.7.1.21|MetaCyc: PWY-7199|Reactome: R-HSA-73614 SHXM_RS37555 be2f11881258a12deaff84a30c11ea2c 214 Gene3D G3DSA:3.30.60.20 144 194 7.7E-5 T 17-03-2017 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 Gene3D G3DSA:3.40.640.10 45 253 1.1E-53 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 SUPERFAMILY SSF53383 27 381 2.53E-82 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 Gene3D G3DSA:3.90.1150.10 254 381 7.2E-16 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 159 183 4.1E-12 T 17-03-2017 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 92 112 4.1E-12 T 17-03-2017 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 225 249 4.1E-12 T 17-03-2017 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 PRINTS PR00753 1-aminocyclopropane-1-carboxylate synthase signature 114 135 4.1E-12 T 17-03-2017 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 Pfam PF00155 Aminotransferase class I and II 32 380 1.7E-37 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS41650 802f62dcc233b9fa585db09bad5839ab 389 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 231 244 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS20980 bd0b76be062c662b3ebdf9e208a383c5 304 SMART SM00530 32 104 0.0021 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS20980 bd0b76be062c662b3ebdf9e208a383c5 304 Pfam PF13560 Helix-turn-helix domain 28 107 8.3E-16 T 17-03-2017 SHXM_RS20980 bd0b76be062c662b3ebdf9e208a383c5 304 Gene3D G3DSA:1.10.260.40 27 101 1.1E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04755 3ebc9ac5514f97c962c6509d714694c7 354 SUPERFAMILY SSF51679 1 350 1.23E-70 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS04755 3ebc9ac5514f97c962c6509d714694c7 354 Gene3D G3DSA:3.20.20.30 1 350 2.9E-78 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS04755 3ebc9ac5514f97c962c6509d714694c7 354 Pfam PF00296 Luciferase-like monooxygenase 7 311 6.6E-52 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS22720 19ebe0104cd8960f10e55e4b5b48c342 249 Gene3D G3DSA:1.10.1780.10 98 234 2.3E-34 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS22720 19ebe0104cd8960f10e55e4b5b48c342 249 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 188 236 2.6E-12 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS22720 19ebe0104cd8960f10e55e4b5b48c342 249 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 112 163 3.5E-10 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS22720 19ebe0104cd8960f10e55e4b5b48c342 249 SUPERFAMILY SSF81923 100 234 2.06E-24 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 Gene3D G3DSA:2.40.50.140 2 56 9.3E-24 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 Pfam PF00313 'Cold-shock' DNA-binding domain 3 56 3.5E-24 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 34 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 PRINTS PR00050 Cold shock protein signature 25 34 2.6E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 PRINTS PR00050 Cold shock protein signature 40 58 2.6E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 PRINTS PR00050 Cold shock protein signature 4 19 2.6E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 SUPERFAMILY SSF50249 2 56 4.16E-19 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS39305 7cd3e317036fe05029fe7efeb8ab908b 80 SMART SM00357 3 67 9.0E-22 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS02785 e9cce1b7648f7d2f50a93e074812334d 293 Gene3D G3DSA:3.90.1200.10 95 268 1.9E-16 T 17-03-2017 SHXM_RS02785 e9cce1b7648f7d2f50a93e074812334d 293 PIRSF PIRSF006221 33 293 2.6E-55 T 17-03-2017 IPR016477 Fructosamine/Ketosamine-3-kinase Reactome: R-HSA-163841 SHXM_RS02785 e9cce1b7648f7d2f50a93e074812334d 293 SUPERFAMILY SSF56112 33 283 2.77E-39 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS02785 e9cce1b7648f7d2f50a93e074812334d 293 Pfam PF03881 Fructosamine kinase 59 286 9.6E-44 T 17-03-2017 IPR016477 Fructosamine/Ketosamine-3-kinase Reactome: R-HSA-163841 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 SUPERFAMILY SSF55347 134 290 1.05E-62 T 17-03-2017 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 SMART SM00859 10 126 2.7E-14 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 SUPERFAMILY SSF51735 7 158 5.23E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 Hamap MF_01657 Acetaldehyde dehydrogenase [mhpF]. 1 321 141.178 T 17-03-2017 IPR003361 Acetaldehyde dehydrogenase GO:0008774|GO:0019439|GO:0055114 KEGG: 00360+1.2.1.10|KEGG: 00362+1.2.1.10|KEGG: 00620+1.2.1.10|KEGG: 00621+1.2.1.10|KEGG: 00622+1.2.1.10|KEGG: 00650+1.2.1.10|MetaCyc: PWY-5162|MetaCyc: PWY-5436|MetaCyc: PWY-5480|MetaCyc: PWY-6587|MetaCyc: PWY-7085|MetaCyc: PWY-7180 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 Pfam PF01118 Semialdehyde dehydrogenase, NAD binding domain 10 123 2.5E-13 T 17-03-2017 IPR000534 Semialdehyde dehydrogenase, NAD-binding GO:0016620|GO:0051287|GO:0055114 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 Gene3D G3DSA:3.30.360.10 147 290 2.7E-72 T 17-03-2017 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 Gene3D G3DSA:3.40.50.720 6 146 7.6E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 Pfam PF09290 Prokaryotic acetaldehyde dehydrogenase, dimerisation 134 290 2.5E-63 T 17-03-2017 IPR015426 Acetaldehyde dehydrogenase, C-terminal GO:0008774|GO:0019439|GO:0055114 KEGG: 00360+1.2.1.10|KEGG: 00362+1.2.1.10|KEGG: 00620+1.2.1.10|KEGG: 00621+1.2.1.10|KEGG: 00622+1.2.1.10|KEGG: 00650+1.2.1.10|MetaCyc: PWY-5162|MetaCyc: PWY-5436|MetaCyc: PWY-5480|MetaCyc: PWY-6587|MetaCyc: PWY-7085|MetaCyc: PWY-7180 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 PIRSF PIRSF015689 5 321 1.8E-131 T 17-03-2017 IPR003361 Acetaldehyde dehydrogenase GO:0008774|GO:0019439|GO:0055114 KEGG: 00360+1.2.1.10|KEGG: 00362+1.2.1.10|KEGG: 00620+1.2.1.10|KEGG: 00621+1.2.1.10|KEGG: 00622+1.2.1.10|KEGG: 00650+1.2.1.10|MetaCyc: PWY-5162|MetaCyc: PWY-5436|MetaCyc: PWY-5480|MetaCyc: PWY-6587|MetaCyc: PWY-7085|MetaCyc: PWY-7180 SHXM_RS11265 175261eaaa993f28b89d602dad7a3ed8 321 TIGRFAM TIGR03215 ac_ald_DH_ac: acetaldehyde dehydrogenase (acetylating) 8 314 1.4E-140 T 17-03-2017 IPR003361 Acetaldehyde dehydrogenase GO:0008774|GO:0019439|GO:0055114 KEGG: 00360+1.2.1.10|KEGG: 00362+1.2.1.10|KEGG: 00620+1.2.1.10|KEGG: 00621+1.2.1.10|KEGG: 00622+1.2.1.10|KEGG: 00650+1.2.1.10|MetaCyc: PWY-5162|MetaCyc: PWY-5436|MetaCyc: PWY-5480|MetaCyc: PWY-6587|MetaCyc: PWY-7085|MetaCyc: PWY-7180 SHXM_RS46605 0c17e282d2821b319f76ef7fe4a8a70d 528 Pfam PF00999 Sodium/hydrogen exchanger family 7 403 1.6E-60 T 17-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SHXM_RS46605 0c17e282d2821b319f76ef7fe4a8a70d 528 TIGRFAM TIGR00831 a_cpa1: Na+/H+ antiporter 6 515 4.1E-116 T 17-03-2017 IPR004705 Cation/H+ exchanger, CPA1 family, bacteria GO:0006812|GO:0015299|GO:0016021 SHXM_RS47565 69740ef449210c7ada3b8f6ca5fcb4a5 240 Gene3D G3DSA:3.40.109.10 7 205 3.0E-35 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS47565 69740ef449210c7ada3b8f6ca5fcb4a5 240 SUPERFAMILY SSF55469 7 91 8.64E-33 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS47565 69740ef449210c7ada3b8f6ca5fcb4a5 240 SUPERFAMILY SSF55469 126 205 8.64E-33 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS47565 69740ef449210c7ada3b8f6ca5fcb4a5 240 Pfam PF00881 Nitroreductase family 13 201 4.5E-26 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS09955 5b50ffd1f443d59c9266b432a150f52c 377 SUPERFAMILY SSF53098 105 347 5.46E-24 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09955 5b50ffd1f443d59c9266b432a150f52c 377 Pfam PF13006 Insertion element 4 transposase N-terminal 1 90 1.2E-29 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS09955 5b50ffd1f443d59c9266b432a150f52c 377 Pfam PF01609 Transposase DDE domain 107 333 1.7E-19 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS35320 c107fc463bae25229b3d7babead531fe 877 PRINTS PR01217 Proline rich extensin signature 637 649 1.6E-10 T 17-03-2017 SHXM_RS35320 c107fc463bae25229b3d7babead531fe 877 PRINTS PR01217 Proline rich extensin signature 828 853 1.6E-10 T 17-03-2017 SHXM_RS35320 c107fc463bae25229b3d7babead531fe 877 PRINTS PR01217 Proline rich extensin signature 810 827 1.6E-10 T 17-03-2017 SHXM_RS35320 c107fc463bae25229b3d7babead531fe 877 PRINTS PR01217 Proline rich extensin signature 782 798 1.6E-10 T 17-03-2017 SHXM_RS35320 c107fc463bae25229b3d7babead531fe 877 SUPERFAMILY SSF52540 147 325 6.49E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35320 c107fc463bae25229b3d7babead531fe 877 Gene3D G3DSA:3.40.50.300 145 249 1.1E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04120 0221a2843f6d1d0c5c7fabbfeac89fff 440 Gene3D G3DSA:3.50.50.60 1 186 3.0E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04120 0221a2843f6d1d0c5c7fabbfeac89fff 440 Gene3D G3DSA:3.50.50.60 297 330 3.0E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04120 0221a2843f6d1d0c5c7fabbfeac89fff 440 SUPERFAMILY SSF51905 1 184 5.4E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04120 0221a2843f6d1d0c5c7fabbfeac89fff 440 SUPERFAMILY SSF51905 295 339 5.4E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS04120 0221a2843f6d1d0c5c7fabbfeac89fff 440 SUPERFAMILY SSF51905 381 428 5.4E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 SUPERFAMILY SSF46689 239 288 1.66E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 Pfam PF12833 Helix-turn-helix domain 209 284 2.4E-17 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 Gene3D G3DSA:1.10.10.60 187 240 1.9E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 SMART SM00342 203 286 8.8E-25 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 240 282 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 Gene3D G3DSA:1.10.10.60 241 284 8.5E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 Pfam PF06719 AraC-type transcriptional regulator N-terminus 22 174 4.7E-45 T 17-03-2017 IPR009594 Transcription regulator HTH, AraC, N-terminal SHXM_RS01245 5310c559ec65d6a002505225f78e0d94 301 SUPERFAMILY SSF46689 188 237 3.18E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19235 97a0008c57bf232e4c9585f36b1cb39e 1044 Pfam PF12972 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain 469 734 8.7E-68 T 17-03-2017 IPR024732 Alpha-N-acetylglucosaminidase, C-terminal KEGG: 00531+3.2.1.50|Reactome: R-HSA-2024096|Reactome: R-HSA-2206282 SHXM_RS19235 97a0008c57bf232e4c9585f36b1cb39e 1044 Pfam PF12971 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain 48 128 1.1E-23 T 17-03-2017 IPR024240 Alpha-N-acetylglucosaminidase, N-terminal KEGG: 00531+3.2.1.50|Reactome: R-HSA-2024096|Reactome: R-HSA-2206282 SHXM_RS19235 97a0008c57bf232e4c9585f36b1cb39e 1044 Pfam PF05089 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain 142 461 5.1E-100 T 17-03-2017 IPR024733 Alpha-N-acetylglucosaminidase, tim-barrel domain KEGG: 00531+3.2.1.50|Reactome: R-HSA-2024096|Reactome: R-HSA-2206282 SHXM_RS00450 4af2c4d1b955caf75a39644737b55efd 435 Pfam PF04326 Putative DNA-binding domain 44 153 5.5E-12 T 17-03-2017 IPR007421 Schlafen, AAA domain GO:0005524 SHXM_RS29465 316c643b89bbd287e6086b60dd0f1dd0 452 Pfam PF07690 Major Facilitator Superfamily 247 435 1.7E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS29465 316c643b89bbd287e6086b60dd0f1dd0 452 Gene3D G3DSA:1.20.1250.20 14 221 7.3E-25 T 17-03-2017 SHXM_RS29465 316c643b89bbd287e6086b60dd0f1dd0 452 Gene3D G3DSA:1.20.1250.20 239 433 1.0E-19 T 17-03-2017 SHXM_RS29465 316c643b89bbd287e6086b60dd0f1dd0 452 Pfam PF00083 Sugar (and other) transporter 16 221 1.3E-22 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS29465 316c643b89bbd287e6086b60dd0f1dd0 452 SUPERFAMILY SSF103473 12 427 9.55E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS29465 316c643b89bbd287e6086b60dd0f1dd0 452 ProSitePatterns PS00217 Sugar transport proteins signature 2. 125 150 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS17800 843096bc38dae0edcf4098be35f5fa83 111 Pfam PF01883 Domain of unknown function DUF59 13 73 4.5E-19 T 17-03-2017 IPR002744 Domain of unknown function DUF59 SHXM_RS17800 843096bc38dae0edcf4098be35f5fa83 111 SUPERFAMILY SSF117916 11 105 1.05E-27 T 17-03-2017 SHXM_RS47085 8379d4c05161159adce503c49f746080 277 Pfam PF00378 Enoyl-CoA hydratase/isomerase 24 275 3.9E-55 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS47085 8379d4c05161159adce503c49f746080 277 Gene3D G3DSA:3.90.226.10 6 271 1.7E-72 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47085 8379d4c05161159adce503c49f746080 277 SUPERFAMILY SSF52096 11 276 5.49E-74 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS38945 057c9247c4996ac75936a75a4ac5d65c 176 SUPERFAMILY SSF158694 8 161 1.06E-39 T 17-03-2017 SHXM_RS38945 057c9247c4996ac75936a75a4ac5d65c 176 Gene3D G3DSA:1.10.3330.10 17 162 5.9E-40 T 17-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 SHXM_RS38945 057c9247c4996ac75936a75a4ac5d65c 176 TIGRFAM TIGR03180 UraD_2: OHCU decarboxylase 12 161 1.5E-50 T 17-03-2017 IPR017595 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, type 2 SHXM_RS38945 057c9247c4996ac75936a75a4ac5d65c 176 Pfam PF09349 OHCU decarboxylase 13 158 1.1E-33 T 17-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 SHXM_RS29940 8590fe853dc689b7522bd2bacfc9d210 332 Pfam PF01384 Phosphate transporter family 20 165 5.0E-39 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS29940 8590fe853dc689b7522bd2bacfc9d210 332 Pfam PF01384 Phosphate transporter family 165 319 1.2E-45 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS26970 1e468c7dd3ef6b2b2e5fe7ee02c56483 153 Pfam PF07332 Putative Actinobacterial Holin-X, holin superfamily III 13 128 3.0E-27 T 17-03-2017 IPR009937 Putative Actinobacterial Holin-X, holin superfamily III SHXM_RS42635 524ef1f679bd0759c9f33e7a05662601 201 Gene3D G3DSA:1.10.357.10 6 190 1.9E-18 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS42635 524ef1f679bd0759c9f33e7a05662601 201 SUPERFAMILY SSF46689 12 79 9.48E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS42635 524ef1f679bd0759c9f33e7a05662601 201 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 56 9.3E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 PRINTS PR00723 Subtilisin serine protease family (S8) signature 158 177 4.6E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 PRINTS PR00723 Subtilisin serine protease family (S8) signature 352 368 4.6E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 PRINTS PR00723 Subtilisin serine protease family (S8) signature 196 209 4.6E-20 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 Pfam PF00082 Subtilase family 158 388 2.0E-36 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 353 363 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 163 174 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 SUPERFAMILY SSF52743 135 402 1.22E-71 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 SUPERFAMILY SSF54897 47 116 2.21E-6 T 17-03-2017 IPR009020 Proteinase propeptide inhibitor SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 Gene3D G3DSA:3.40.50.200 134 396 5.1E-79 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 Pfam PF05922 Peptidase inhibitor I9 71 117 8.0E-6 T 17-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 SHXM_RS35715 e3fe7f5af96fc0d4ef21b381fb0703d6 409 Gene3D G3DSA:3.30.70.80 46 117 3.4E-10 T 17-03-2017 IPR010259 Peptidase S8 propeptide/proteinase inhibitor I9 SHXM_RS48380 520b6f1b3833c5eb92ef9d833dd64592 789 SUPERFAMILY SSF49313 703 784 1.3E-7 T 17-03-2017 IPR015919 Cadherin-like GO:0005509|GO:0016020 SHXM_RS48380 520b6f1b3833c5eb92ef9d833dd64592 789 Pfam PF05345 Putative Ig domain 732 771 2.1E-8 T 17-03-2017 IPR008009 Putative Ig SHXM_RS48380 520b6f1b3833c5eb92ef9d833dd64592 789 Gene3D G3DSA:2.60.40.10 711 784 2.2E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 Pfam PF13377 Periplasmic binding protein-like domain 184 347 4.6E-31 T 17-03-2017 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 SUPERFAMILY SSF47413 2 60 4.57E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 Pfam PF00356 Bacterial regulatory proteins, lacI family 4 49 3.5E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 Gene3D G3DSA:3.40.50.2300 63 188 1.2E-44 T 17-03-2017 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 Gene3D G3DSA:3.40.50.2300 189 326 7.2E-51 T 17-03-2017 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 SMART SM00354 2 72 2.6E-21 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 Gene3D G3DSA:1.10.260.40 3 62 2.5E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 SUPERFAMILY SSF53822 62 350 1.18E-57 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS22425 30d4ea281deb2cfa0303235fe2084847 352 ProSitePatterns PS00356 LacI-type HTH domain signature. 5 23 - T 17-03-2017 SHXM_RS34985 ff495c0458453a95fb140eb8948d561d 208 SMART SM00347 79 179 5.0E-10 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS34985 ff495c0458453a95fb140eb8948d561d 208 SUPERFAMILY SSF46785 82 192 2.84E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34985 ff495c0458453a95fb140eb8948d561d 208 Pfam PF01047 MarR family 91 139 6.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS34985 ff495c0458453a95fb140eb8948d561d 208 Gene3D G3DSA:1.10.10.10 78 196 1.7E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25920 2590a46848cdcc1a1e430b360e59d1dc 142 Pfam PF00472 RF-1 domain 10 136 6.4E-23 T 17-03-2017 IPR000352 Peptide chain release factor class I/class II GO:0003747|GO:0006415 SHXM_RS25920 2590a46848cdcc1a1e430b360e59d1dc 142 Gene3D G3DSA:3.30.160.200 10 108 3.2E-27 T 17-03-2017 SHXM_RS25920 2590a46848cdcc1a1e430b360e59d1dc 142 SUPERFAMILY SSF75620 11 103 1.1E-11 T 17-03-2017 SHXM_RS02400 2405a9d0450116a0dc225aa2b0d4dc0f 357 SUPERFAMILY SSF53659 7 352 8.26E-111 T 17-03-2017 SHXM_RS02400 2405a9d0450116a0dc225aa2b0d4dc0f 357 SMART SM01329 9 349 2.4E-154 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS02400 2405a9d0450116a0dc225aa2b0d4dc0f 357 Gene3D G3DSA:3.40.718.10 9 344 1.4E-115 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS02400 2405a9d0450116a0dc225aa2b0d4dc0f 357 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 242 261 - T 17-03-2017 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-71403 SHXM_RS02400 2405a9d0450116a0dc225aa2b0d4dc0f 357 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 10 347 1.8E-93 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 Gene3D G3DSA:3.40.50.2300 6 127 6.9E-39 T 17-03-2017 SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 Pfam PF00072 Response regulator receiver domain 9 118 9.7E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 Pfam PF00486 Transcriptional regulatory protein, C terminal 151 226 3.8E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 SMART SM00448 7 118 2.6E-39 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 Gene3D G3DSA:1.10.10.10 128 228 6.3E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 SMART SM00862 151 226 1.3E-26 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS28695 bb6fbcc8410f0a4c66c617f3079cc0c3 239 SUPERFAMILY SSF52172 6 182 1.16E-42 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS06055 b298be48717420d6de56f922610e71f0 310 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 304 8.7E-31 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06055 b298be48717420d6de56f922610e71f0 310 SUPERFAMILY SSF161098 90 291 2.49E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06055 b298be48717420d6de56f922610e71f0 310 Gene3D G3DSA:1.10.3720.10 88 300 1.3E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS00345 4f31849cc598be2cd73b003159efe5e6 438 SUPERFAMILY SSF103473 5 421 8.89E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS00345 4f31849cc598be2cd73b003159efe5e6 438 Gene3D G3DSA:1.20.1250.20 15 219 3.2E-21 T 17-03-2017 SHXM_RS00345 4f31849cc598be2cd73b003159efe5e6 438 Gene3D G3DSA:1.20.1250.20 240 424 1.4E-19 T 17-03-2017 SHXM_RS00345 4f31849cc598be2cd73b003159efe5e6 438 Pfam PF07690 Major Facilitator Superfamily 51 365 9.4E-23 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS00345 4f31849cc598be2cd73b003159efe5e6 438 ProSitePatterns PS00217 Sugar transport proteins signature 2. 124 149 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS02970 5ac002b6e042c9750a580117e3b36352 236 Gene3D G3DSA:3.30.1360.40 7 80 3.2E-12 T 17-03-2017 IPR024946 Arginine repressor C-terminal-like domain SHXM_RS02970 5ac002b6e042c9750a580117e3b36352 236 Gene3D G3DSA:2.40.100.10 94 226 2.9E-36 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS02970 5ac002b6e042c9750a580117e3b36352 236 SUPERFAMILY SSF50891 94 223 1.29E-34 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS02970 5ac002b6e042c9750a580117e3b36352 236 SMART SM00796 5 207 1.5E-37 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS02970 5ac002b6e042c9750a580117e3b36352 236 Pfam PF02682 Allophanate hydrolase subunit 1 7 206 4.0E-50 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS02970 5ac002b6e042c9750a580117e3b36352 236 SUPERFAMILY SSF160467 8 98 2.75E-13 T 17-03-2017 SHXM_RS42575 195e80d26da041684191cfd76e732205 190 Gene3D G3DSA:2.40.128.110 28 182 2.7E-29 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS42575 195e80d26da041684191cfd76e732205 190 SMART SM00867 16 183 2.7E-20 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS42575 195e80d26da041684191cfd76e732205 190 SUPERFAMILY SSF101874 31 181 4.45E-25 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS42575 195e80d26da041684191cfd76e732205 190 Pfam PF04264 YceI-like domain 31 180 6.1E-21 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS48945 6e345e9e9b151dccb0b8cab1292774b5 268 SUPERFAMILY SSF53098 12 228 2.28E-13 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS48945 6e345e9e9b151dccb0b8cab1292774b5 268 Pfam PF13546 DDE superfamily endonuclease 20 267 7.1E-87 T 17-03-2017 SHXM_RS20045 80c4a0b8eba4dbdfda26eb4e4cb6e9b9 197 Gene3D G3DSA:1.10.260.40 71 135 9.9E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20045 80c4a0b8eba4dbdfda26eb4e4cb6e9b9 197 Pfam PF01381 Helix-turn-helix 75 129 6.8E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS20045 80c4a0b8eba4dbdfda26eb4e4cb6e9b9 197 SUPERFAMILY SSF47413 66 133 1.36E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20045 80c4a0b8eba4dbdfda26eb4e4cb6e9b9 197 SMART SM00530 74 129 4.9E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS34590 1fc627335f981784b5b240c5e1a469bd 333 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 123 321 8.8E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34590 1fc627335f981784b5b240c5e1a469bd 333 SUPERFAMILY SSF161098 90 318 1.7E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34590 1fc627335f981784b5b240c5e1a469bd 333 Gene3D G3DSA:1.10.3720.10 42 319 1.2E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27560 512797de6a56a8e58841fdb90b3de1d3 388 Gene3D G3DSA:3.40.47.10 207 234 9.7E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS27560 512797de6a56a8e58841fdb90b3de1d3 388 Gene3D G3DSA:3.40.47.10 16 119 9.7E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS27560 512797de6a56a8e58841fdb90b3de1d3 388 SUPERFAMILY SSF53901 11 237 2.11E-22 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS27560 512797de6a56a8e58841fdb90b3de1d3 388 SUPERFAMILY SSF53901 266 377 3.2E-14 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS27560 512797de6a56a8e58841fdb90b3de1d3 388 PIRSF PIRSF000429 10 339 1.4E-20 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS35580 90a44aed72e3d3e14ce721f20912ad94 150 Gene3D G3DSA:3.30.565.10 52 143 5.1E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35580 90a44aed72e3d3e14ce721f20912ad94 150 SUPERFAMILY SSF55874 48 131 4.35E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35580 90a44aed72e3d3e14ce721f20912ad94 150 Pfam PF13581 Histidine kinase-like ATPase domain 29 128 4.4E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07745 33e4f1376416dca9ad0adf5e7369a20b 375 SUPERFAMILY SSF53613 29 320 9.04E-53 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS07745 33e4f1376416dca9ad0adf5e7369a20b 375 Gene3D G3DSA:3.40.1190.20 28 324 2.9E-56 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS07745 33e4f1376416dca9ad0adf5e7369a20b 375 Pfam PF00294 pfkB family carbohydrate kinase 33 310 9.4E-33 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS07745 33e4f1376416dca9ad0adf5e7369a20b 375 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 265 278 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS10005 27e45cb7acbbe4e7525234ad9caf5d35 337 Pfam PF13814 Replication-relaxation 52 237 2.6E-39 T 17-03-2017 IPR025855 Plasmid replication-relaxation SHXM_RS14720 4aecc9c801dde86fec848a7e4fe8c346 616 Gene3D G3DSA:3.20.20.70 294 425 1.8E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS14720 4aecc9c801dde86fec848a7e4fe8c346 616 Pfam PF14508 Glycosyl-hydrolase 97 N-terminal 47 279 7.4E-40 T 17-03-2017 IPR029486 Glycosyl-hydrolase 97, N-terminal domain SHXM_RS14720 4aecc9c801dde86fec848a7e4fe8c346 616 Pfam PF10566 Glycoside hydrolase 97 284 520 3.8E-69 T 17-03-2017 IPR019563 Glycosyl-hydrolase 97, catalytic domain SHXM_RS14720 4aecc9c801dde86fec848a7e4fe8c346 616 SUPERFAMILY SSF51445 284 494 2.32E-21 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS14720 4aecc9c801dde86fec848a7e4fe8c346 616 Pfam PF14509 Glycosyl-hydrolase 97 C-terminal, oligomerisation 522 612 9.2E-24 T 17-03-2017 IPR029483 Glycosyl-hydrolase 97, C-terminal oligomerisation domain SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 ProSitePatterns PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 218 249 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 SMART SM00922 171 268 4.1E-20 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 32 151 6.8E-14 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 Gene3D G3DSA:3.30.390.10 27 153 4.8E-34 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 Pfam PF13378 Enolase C-terminal domain-like 183 382 3.5E-54 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 Gene3D G3DSA:3.20.20.120 154 384 1.5E-66 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 SUPERFAMILY SSF51604 139 385 3.28E-61 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS01275 6098e65e7e012a4f52ac753c3b8c9e70 398 SUPERFAMILY SSF54826 28 154 3.38E-27 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS20115 2164b78dbbb3f8e609da6a75dca622e0 184 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 1.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20115 2164b78dbbb3f8e609da6a75dca622e0 184 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 1.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20115 2164b78dbbb3f8e609da6a75dca622e0 184 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 57 3.2E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20115 2164b78dbbb3f8e609da6a75dca622e0 184 SUPERFAMILY SSF46689 2 74 7.48E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20115 2164b78dbbb3f8e609da6a75dca622e0 184 SUPERFAMILY SSF48498 77 155 1.24E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS20115 2164b78dbbb3f8e609da6a75dca622e0 184 Gene3D G3DSA:1.10.357.10 1 180 4.0E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS14915 3b5d16d1d20f39bae568aff61b434418 217 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 60 2.1E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14915 3b5d16d1d20f39bae568aff61b434418 217 SUPERFAMILY SSF46689 7 77 4.69E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14915 3b5d16d1d20f39bae568aff61b434418 217 Gene3D G3DSA:1.10.357.10 58 201 1.4E-25 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS14915 3b5d16d1d20f39bae568aff61b434418 217 Gene3D G3DSA:1.10.10.60 6 57 9.3E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14915 3b5d16d1d20f39bae568aff61b434418 217 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 38 61 1.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14915 3b5d16d1d20f39bae568aff61b434418 217 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 17 30 1.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 Gene3D G3DSA:3.30.390.10 11 117 7.5E-42 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 SUPERFAMILY SSF51604 99 389 1.97E-75 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 SMART SM00922 129 260 3.4E-17 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 SUPERFAMILY SSF54826 10 113 5.53E-31 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 Gene3D G3DSA:3.20.20.120 118 368 2.5E-80 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 Pfam PF13378 Enolase C-terminal domain-like 192 380 5.0E-47 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 ProSitePatterns PS00909 Mandelate racemase / muconate lactonizing enzyme family signature 2. 210 241 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 86 111 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS44770 bef5f437a2f228eb961ee25890282b62 405 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 15 111 1.2E-31 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 PRINTS PR00069 Aldo-keto reductase signature 53 77 4.6E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 PRINTS PR00069 Aldo-keto reductase signature 117 135 4.6E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 PRINTS PR00069 Aldo-keto reductase signature 148 165 4.6E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 Gene3D G3DSA:3.20.20.100 27 339 5.5E-82 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 SUPERFAMILY SSF51430 27 338 7.99E-81 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 148 165 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS08210 daa9fbe550daa4b0d1638af7bc46411f 342 Pfam PF00248 Aldo/keto reductase family 29 329 1.5E-63 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS46575 095dd88f53b792ec4efe56b5f4ce4a5f 566 ProSitePatterns PS00455 Putative AMP-binding domain signature. 182 193 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS46575 095dd88f53b792ec4efe56b5f4ce4a5f 566 SUPERFAMILY SSF56801 44 554 6.54E-68 T 17-03-2017 SHXM_RS46575 095dd88f53b792ec4efe56b5f4ce4a5f 566 Gene3D G3DSA:3.40.50.980 53 187 3.6E-20 T 17-03-2017 SHXM_RS46575 095dd88f53b792ec4efe56b5f4ce4a5f 566 Gene3D G3DSA:2.30.38.10 362 436 3.7E-15 T 17-03-2017 SHXM_RS46575 095dd88f53b792ec4efe56b5f4ce4a5f 566 Gene3D G3DSA:3.40.50.980 188 342 2.3E-14 T 17-03-2017 SHXM_RS46575 095dd88f53b792ec4efe56b5f4ce4a5f 566 Pfam PF00501 AMP-binding enzyme 51 441 1.0E-48 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS48750 92ba46f2340d41f7a18239952c84c5ff 284 SUPERFAMILY SSF55729 108 269 4.56E-10 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS48750 92ba46f2340d41f7a18239952c84c5ff 284 Gene3D G3DSA:3.40.630.30 151 263 5.2E-9 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS10310 d12cea841a436ca9f9f6601a9c5dcc8c 355 SUPERFAMILY SSF53098 175 326 1.14E-15 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10310 d12cea841a436ca9f9f6601a9c5dcc8c 355 Gene3D G3DSA:3.30.420.10 174 324 1.3E-13 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10310 d12cea841a436ca9f9f6601a9c5dcc8c 355 SUPERFAMILY SSF46689 75 150 2.69E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS10310 d12cea841a436ca9f9f6601a9c5dcc8c 355 Pfam PF13276 HTH-like domain 105 158 3.2E-8 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS10310 d12cea841a436ca9f9f6601a9c5dcc8c 355 Pfam PF13683 Integrase core domain 260 324 2.1E-11 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS10785 88ae5faad666d1a3d7ff7d1a52986fca 436 Gene3D G3DSA:3.40.50.980 163 325 5.0E-36 T 17-03-2017 SHXM_RS10785 88ae5faad666d1a3d7ff7d1a52986fca 436 Pfam PF00501 AMP-binding enzyme 17 436 7.5E-69 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS10785 88ae5faad666d1a3d7ff7d1a52986fca 436 Gene3D G3DSA:3.40.50.980 8 162 2.4E-21 T 17-03-2017 SHXM_RS10785 88ae5faad666d1a3d7ff7d1a52986fca 436 Gene3D G3DSA:2.30.38.10 359 431 1.0E-24 T 17-03-2017 SHXM_RS10785 88ae5faad666d1a3d7ff7d1a52986fca 436 SUPERFAMILY SSF56801 8 436 3.53E-87 T 17-03-2017 SHXM_RS10785 88ae5faad666d1a3d7ff7d1a52986fca 436 ProSitePatterns PS00455 Putative AMP-binding domain signature. 156 167 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS21170 45d778d7d015f3d861e92f39170be5cf 69 Pfam PF13384 Homeodomain-like domain 42 63 6.7E-6 T 17-03-2017 SHXM_RS21170 45d778d7d015f3d861e92f39170be5cf 69 Gene3D G3DSA:1.10.10.60 37 64 7.3E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS21170 45d778d7d015f3d861e92f39170be5cf 69 SUPERFAMILY SSF88659 42 66 2.16E-5 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS41245 f3411764ad1c98565805b1bbd97e3c56 250 Pfam PF01738 Dienelactone hydrolase family 16 246 2.4E-38 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS41245 f3411764ad1c98565805b1bbd97e3c56 250 Gene3D G3DSA:3.40.50.1820 2 245 3.3E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41245 f3411764ad1c98565805b1bbd97e3c56 250 SUPERFAMILY SSF53474 1 247 4.41E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS43595 5fec4e6e33b22c8144ef88b4353b9113 268 Pfam PF00378 Enoyl-CoA hydratase/isomerase 16 266 6.2E-54 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS43595 5fec4e6e33b22c8144ef88b4353b9113 268 Gene3D G3DSA:3.90.226.10 5 266 1.7E-78 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS43595 5fec4e6e33b22c8144ef88b4353b9113 268 SUPERFAMILY SSF52096 4 266 2.89E-80 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS36395 b6520a4a9c607dd53cfe034a00d75a70 161 Pfam PF12028 Protein of unknown function (DUF3515) 17 158 2.9E-30 T 17-03-2017 IPR021903 Protein of unknown function DUF3515 SHXM_RS40970 1181ba6a300a640346cbc88cb8097c80 1084 SUPERFAMILY SSF88713 139 347 1.22E-22 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS40970 1181ba6a300a640346cbc88cb8097c80 1084 Gene3D G3DSA:3.20.110.10 139 330 3.9E-11 T 17-03-2017 IPR027291 Glycoside hydrolase 38/57, N-terminal domain SHXM_RS40970 1181ba6a300a640346cbc88cb8097c80 1084 Pfam PF07748 Glycosyl hydrolases family 38 C-terminal domain 585 851 5.5E-10 T 17-03-2017 IPR011682 Glycosyl hydrolase family 38, C-terminal GO:0006013|GO:0015923 SHXM_RS40970 1181ba6a300a640346cbc88cb8097c80 1084 SUPERFAMILY SSF74650 700 1052 9.73E-19 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS40970 1181ba6a300a640346cbc88cb8097c80 1084 SUPERFAMILY SSF74650 578 667 9.73E-19 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS40970 1181ba6a300a640346cbc88cb8097c80 1084 Pfam PF01074 Glycosyl hydrolases family 38 N-terminal domain 145 442 1.4E-12 T 17-03-2017 IPR000602 Glycoside hydrolase family 38, N-terminal domain GO:0004559|GO:0005975 SHXM_RS28345 467bee304ec0bc0f377c31e196e3e7c7 253 Pfam PF00588 SpoU rRNA Methylase family 114 243 5.0E-24 T 17-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SHXM_RS28345 467bee304ec0bc0f377c31e196e3e7c7 253 SUPERFAMILY SSF75217 104 246 6.11E-28 T 17-03-2017 IPR029028 Alpha/beta knot methyltransferases SHXM_RS28345 467bee304ec0bc0f377c31e196e3e7c7 253 Gene3D G3DSA:3.40.1280.10 110 246 5.2E-27 T 17-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 35 315 1.8E-28 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 Gene3D G3DSA:3.40.50.720 112 286 4.0E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 112 285 3.1E-55 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 Gene3D G3DSA:3.40.50.720 17 111 2.3E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 SUPERFAMILY SSF51735 106 285 4.34E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 SUPERFAMILY SSF52283 18 136 6.38E-29 T 17-03-2017 SHXM_RS01745 c4a137d02694caae837b03282bd74e4b 317 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 224 240 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS05340 29222e73e70306eda4af6cbe773cc538 284 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 111 284 2.1E-38 T 17-03-2017 SHXM_RS05340 29222e73e70306eda4af6cbe773cc538 284 Gene3D G3DSA:3.40.50.720 112 284 1.8E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05340 29222e73e70306eda4af6cbe773cc538 284 SUPERFAMILY SSF51735 111 284 1.3E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05340 29222e73e70306eda4af6cbe773cc538 284 SUPERFAMILY SSF51735 1 98 1.38E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05340 29222e73e70306eda4af6cbe773cc538 284 Pfam PF08659 KR domain 111 284 3.0E-56 T 17-03-2017 IPR013968 Polyketide synthase, ketoreductase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS36790 b2b0c3456ab9c900077f211cb807684b 265 Gene3D G3DSA:1.10.3720.10 12 263 2.0E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36790 b2b0c3456ab9c900077f211cb807684b 265 SUPERFAMILY SSF161098 6 256 1.09E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36790 b2b0c3456ab9c900077f211cb807684b 265 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 86 254 3.2E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 Gene3D G3DSA:1.10.10.60 8 72 1.5E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 ProSitePatterns PS01081 TetR-type HTH domain signature. 32 62 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 SUPERFAMILY SSF46689 8 81 5.08E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 64 2.4E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 SUPERFAMILY SSF48498 85 200 4.67E-29 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 Gene3D G3DSA:1.10.357.10 76 200 5.5E-42 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 1.8E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25010 4d236f704f905e934a088eb8895e833d 202 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 1.8E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS40415 8b6cebb218a079d2b3b5d5ece6cc1a37 301 Gene3D G3DSA:3.40.50.720 3 225 6.5E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40415 8b6cebb218a079d2b3b5d5ece6cc1a37 301 SUPERFAMILY SSF51735 3 259 2.08E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40415 8b6cebb218a079d2b3b5d5ece6cc1a37 301 Pfam PF13460 NAD(P)H-binding 6 119 1.7E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS03880 3837a4c754d91e148f09fe97c2d72941 315 SMART SM00710 254 276 100.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03880 3837a4c754d91e148f09fe97c2d72941 315 SMART SM00710 137 162 0.28 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03880 3837a4c754d91e148f09fe97c2d72941 315 SMART SM00710 196 218 7900.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS03880 3837a4c754d91e148f09fe97c2d72941 315 Pfam PF13229 Right handed beta helix region 110 287 1.2E-11 T 17-03-2017 SHXM_RS03880 3837a4c754d91e148f09fe97c2d72941 315 SUPERFAMILY SSF51126 51 301 9.71E-24 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS03880 3837a4c754d91e148f09fe97c2d72941 315 Gene3D G3DSA:2.160.20.10 64 298 2.2E-16 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS41950 96485c5a98c86b6315211550d187044a 297 Gene3D G3DSA:1.10.260.40 3 87 6.2E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41950 96485c5a98c86b6315211550d187044a 297 SMART SM00530 15 88 3.6E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS41950 96485c5a98c86b6315211550d187044a 297 Pfam PF13560 Helix-turn-helix domain 11 91 4.1E-20 T 17-03-2017 SHXM_RS41950 96485c5a98c86b6315211550d187044a 297 SUPERFAMILY SSF47413 36 86 1.04E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02105 dc782d97fdf1425aeb7f4fba81af56a2 443 Pfam PF06368 Methylaspartate mutase E chain (MutE) 18 388 4.7E-89 T 17-03-2017 IPR006396 Glutamate mutase epsilon subunit GO:0019670|GO:0050097 KEGG: 00630+5.4.99.1|KEGG: 00660+5.4.99.1|MetaCyc: PWY-5087|MetaCyc: PWY-5103|MetaCyc: PWY-6728 SHXM_RS02105 dc782d97fdf1425aeb7f4fba81af56a2 443 PIRSF PIRSF001495 1 426 3.5E-131 T 17-03-2017 IPR006396 Glutamate mutase epsilon subunit GO:0019670|GO:0050097 KEGG: 00630+5.4.99.1|KEGG: 00660+5.4.99.1|MetaCyc: PWY-5087|MetaCyc: PWY-5103|MetaCyc: PWY-6728 SHXM_RS02105 dc782d97fdf1425aeb7f4fba81af56a2 443 Gene3D G3DSA:3.20.20.240 12 366 4.0E-132 T 17-03-2017 IPR014348 Cobalamin (vitamin B12)-dependent enzyme, catalytic subdomain GO:0008152|GO:0016866|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS02105 dc782d97fdf1425aeb7f4fba81af56a2 443 SUPERFAMILY SSF51703 18 410 1.65E-111 T 17-03-2017 IPR016176 Cobalamin (vitamin B12)-dependent enzyme, catalytic GO:0003824|GO:0008152|GO:0031419 Reactome: R-HSA-196741|Reactome: R-HSA-3359475|Reactome: R-HSA-3359478|Reactome: R-HSA-71032 SHXM_RS28255 10816335ba70f3b6eaffcd33b275106a 470 Pfam PF01098 Cell cycle protein 83 449 8.9E-77 T 17-03-2017 IPR001182 Cell cycle protein FtsW/RodA GO:0016021|GO:0051301 SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 Hamap MF_00051 Serine hydroxymethyltransferase [glyA]. 16 430 50.099 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 SUPERFAMILY SSF53383 10 430 8.9E-169 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 Gene3D G3DSA:3.90.1150.10 293 430 4.8E-44 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 ProSitePatterns PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 231 247 - T 17-03-2017 IPR019798 Serine hydroxymethyltransferase, pyridoxal phosphate binding site GO:0004372|GO:0006544|GO:0006563|GO:0030170 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 PIRSF PIRSF000412 6 433 1.5E-155 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 Pfam PF00464 Serine hydroxymethyltransferase 17 398 4.8E-160 T 17-03-2017 IPR001085 Serine hydroxymethyltransferase GO:0016740 KEGG: 00260+2.1.2.1|KEGG: 00460+2.1.2.1|KEGG: 00630+2.1.2.1|KEGG: 00670+2.1.2.1|KEGG: 00680+2.1.2.1|MetaCyc: PWY-1622|MetaCyc: PWY-181|MetaCyc: PWY-2161|MetaCyc: PWY-2201|MetaCyc: PWY-3661|MetaCyc: PWY-3661-1|MetaCyc: PWY-3841|MetaCyc: PWY-5497|Reactome: R-HSA-196757 SHXM_RS41770 70a72ee90bf575f6a9cea90df29175c7 449 Gene3D G3DSA:3.40.640.10 46 292 3.4E-104 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 ProSitePatterns PS00622 LuxR-type HTH domain signature. 165 192 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 Gene3D G3DSA:3.40.50.2300 2 119 3.3E-37 T 17-03-2017 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 SMART SM00421 148 205 6.5E-24 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 Pfam PF00072 Response regulator receiver domain 3 113 5.0E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 SUPERFAMILY SSF52172 2 181 4.07E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 Pfam PF00196 Bacterial regulatory proteins, luxR family 151 205 7.7E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 SMART SM00448 1 114 3.1E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 165 181 4.0E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 151 165 4.0E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 181 193 4.0E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05235 789e29a84f159e5617b28ebb15710158 211 Gene3D G3DSA:1.10.10.10 120 210 4.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48140 308eee5b6158c039e91414e47d053044 419 Pfam PF00589 Phage integrase family 216 374 1.5E-13 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS48140 308eee5b6158c039e91414e47d053044 419 SUPERFAMILY SSF56349 204 389 1.21E-24 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS48140 308eee5b6158c039e91414e47d053044 419 Gene3D G3DSA:1.10.443.10 215 384 2.5E-23 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS48140 308eee5b6158c039e91414e47d053044 419 Gene3D G3DSA:1.10.150.130 141 166 2.4E-8 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS48140 308eee5b6158c039e91414e47d053044 419 Gene3D G3DSA:1.10.150.130 45 100 2.4E-8 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS18095 5bcdd72251137e2c30113b2a7655294e 290 SUPERFAMILY SSF53335 32 267 1.66E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18095 5bcdd72251137e2c30113b2a7655294e 290 Gene3D G3DSA:3.40.50.150 32 277 8.8E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18095 5bcdd72251137e2c30113b2a7655294e 290 Pfam PF08241 Methyltransferase domain 83 189 3.8E-19 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 15 99 3.8E-8 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 249 382 2.2E-24 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 Gene3D G3DSA:1.20.140.10 211 395 8.7E-39 T 17-03-2017 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 SUPERFAMILY SSF56645 10 216 4.19E-34 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 PIRSF PIRSF016578 6 403 2.1E-117 T 17-03-2017 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 SUPERFAMILY SSF47203 242 395 1.12E-10 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 Gene3D G3DSA:2.40.110.10 125 210 7.6E-25 T 17-03-2017 SHXM_RS41205 70cedf659572e3a48f7eaa38264c3497 404 Gene3D G3DSA:1.10.540.10 13 123 9.5E-35 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS30585 090fd7f4f71e4d1ce1b20e725d798a8f 178 SUPERFAMILY SSF109854 6 159 5.49E-6 T 17-03-2017 SHXM_RS30585 090fd7f4f71e4d1ce1b20e725d798a8f 178 Pfam PF12867 DinB superfamily 15 163 9.5E-20 T 17-03-2017 IPR024775 DinB-like domain SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Gene3D G3DSA:3.40.50.300 1059 1289 3.1E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Gene3D G3DSA:3.40.50.300 327 557 1.6E-76 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 SUPERFAMILY SSF90123 1 315 4.32E-66 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 ProSitePatterns PS00211 ABC transporters family signature. 465 479 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Gene3D G3DSA:1.20.1560.10 731 1044 9.3E-76 T 17-03-2017 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Gene3D G3DSA:1.20.1560.10 1 313 9.2E-63 T 17-03-2017 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 SUPERFAMILY SSF52540 324 560 7.48E-85 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 SMART SM00382 353 539 6.7E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 SMART SM00382 1084 1270 2.4E-20 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 SUPERFAMILY SSF52540 1049 1293 1.6E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 SUPERFAMILY SSF90123 731 1044 6.93E-71 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Pfam PF00664 ABC transporter transmembrane region 744 1013 8.9E-39 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Pfam PF00664 ABC transporter transmembrane region 13 281 8.6E-34 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Pfam PF00005 ABC transporter 1076 1224 6.3E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22505 f5a7a6610fdd76dab76be56c4961a3cd 1303 Pfam PF00005 ABC transporter 344 493 1.7E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 Gene3D G3DSA:1.10.10.10 3 83 9.8E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 41 52 3.6E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 31 41 3.6E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 20 31 3.6E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 Gene3D G3DSA:3.40.190.10 94 174 1.9E-18 T 17-03-2017 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 SUPERFAMILY SSF46785 4 85 2.39E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 Pfam PF03466 LysR substrate binding domain 93 281 1.9E-33 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 SUPERFAMILY SSF53850 93 281 9.51E-30 T 17-03-2017 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 Gene3D G3DSA:3.40.190.10 175 256 7.7E-13 T 17-03-2017 SHXM_RS33235 60736286d803414b69f8a2458a3c7e91 306 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 63 5.3E-23 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS31895 ac37cbe25f91583daeae7bbd001a6cf1 191 SUPERFAMILY SSF55729 8 173 6.23E-28 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS31895 ac37cbe25f91583daeae7bbd001a6cf1 191 Pfam PF13420 Acetyltransferase (GNAT) domain 8 167 3.0E-23 T 17-03-2017 SHXM_RS31895 ac37cbe25f91583daeae7bbd001a6cf1 191 Gene3D G3DSA:3.40.630.30 7 176 6.3E-38 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS07450 db3a4bfa6fea42f1047f4be9d6768dae 420 SUPERFAMILY SSF53756 2 376 9.16E-67 T 17-03-2017 SHXM_RS07450 db3a4bfa6fea42f1047f4be9d6768dae 420 Gene3D G3DSA:3.40.50.2000 196 354 9.5E-28 T 17-03-2017 SHXM_RS07450 db3a4bfa6fea42f1047f4be9d6768dae 420 Pfam PF00534 Glycosyl transferases group 1 197 353 4.2E-36 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 SUPERFAMILY SSF46589 29 115 1.67E-14 T 17-03-2017 IPR010978 tRNA-binding arm GO:0000166 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 Pfam PF01409 tRNA synthetases class II core domain (F) 109 368 6.5E-103 T 17-03-2017 IPR002319 Phenylalanyl-tRNA synthetase GO:0000049|GO:0004812|GO:0005524|GO:0005737|GO:0043039 KEGG: 00970+6.1.1.20 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 Gene3D G3DSA:3.30.930.10 26 370 1.2E-119 T 17-03-2017 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 Pfam PF02912 Aminoacyl tRNA synthetase class II, N-terminal domain 37 104 5.5E-17 T 17-03-2017 IPR004188 Phenylalanine-tRNA ligase, class II, N-terminal GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 SUPERFAMILY SSF55681 109 370 2.7E-77 T 17-03-2017 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 TIGRFAM TIGR00468 pheS: phenylalanine--tRNA ligase, alpha subunit 69 367 1.9E-90 T 17-03-2017 IPR004529 Phenylalanyl-tRNA synthetase, class IIc, alpha subunit GO:0000166|GO:0004826|GO:0005524|GO:0005737|GO:0006432 KEGG: 00970+6.1.1.20|Reactome: R-HSA-379716 SHXM_RS13120 88709ffe64c7a1dbd0f88e73b2e96ed1 373 Hamap MF_00281 Phenylalanine--tRNA ligase alpha subunit [pheS]. 25 369 45.978 T 17-03-2017 IPR022911 Phenylalanine-tRNA ligase alpha chain 1, bacterial GO:0004826 KEGG: 00970+6.1.1.20 SHXM_RS46405 efb1d317a2cb1becbb7d479097975b12 120 Pfam PF13564 DoxX-like family 7 110 2.8E-24 T 17-03-2017 IPR032808 DoxX family SHXM_RS33915 5175c74db05dcb7213dbd6c94bf9d1db 546 Gene3D G3DSA:3.40.190.10 209 324 2.0E-26 T 17-03-2017 SHXM_RS33915 5175c74db05dcb7213dbd6c94bf9d1db 546 Gene3D G3DSA:3.90.76.10 49 208 2.0E-32 T 17-03-2017 SHXM_RS33915 5175c74db05dcb7213dbd6c94bf9d1db 546 SUPERFAMILY SSF53850 36 544 3.62E-87 T 17-03-2017 SHXM_RS33915 5175c74db05dcb7213dbd6c94bf9d1db 546 PIRSF PIRSF002741 11 539 1.6E-52 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS33915 5175c74db05dcb7213dbd6c94bf9d1db 546 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 84 466 2.4E-48 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS33915 5175c74db05dcb7213dbd6c94bf9d1db 546 Gene3D G3DSA:3.10.105.10 325 517 8.6E-35 T 17-03-2017 SHXM_RS25695 af5c83215225073c45d01f2eebd8ad59 272 Pfam PF04672 S-adenosyl methyltransferase 8 272 3.6E-112 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS25695 af5c83215225073c45d01f2eebd8ad59 272 SUPERFAMILY SSF53335 16 252 1.97E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS25695 af5c83215225073c45d01f2eebd8ad59 272 PIRSF PIRSF017393 1 272 4.5E-105 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS25695 af5c83215225073c45d01f2eebd8ad59 272 Gene3D G3DSA:3.40.50.150 3 272 1.2E-112 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36235 09fbd3285b9ba8bafd58bdc38443d08b 347 Hamap MF_01035 3-isopropylmalate dehydrogenase [leuB]. 5 345 59.136 T 17-03-2017 IPR023698 3-isopropylmalate dehydrogenase GO:0003862|GO:0009098|GO:0055114 KEGG: 00290+1.1.1.85|KEGG: 00660+1.1.1.85|MetaCyc: PWY-7396 SHXM_RS36235 09fbd3285b9ba8bafd58bdc38443d08b 347 ProSitePatterns PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 239 258 - T 17-03-2017 IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site GO:0000287|GO:0016616|GO:0051287|GO:0055114 Reactome: R-HSA-71403 SHXM_RS36235 09fbd3285b9ba8bafd58bdc38443d08b 347 Gene3D G3DSA:3.40.718.10 5 339 2.8E-115 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS36235 09fbd3285b9ba8bafd58bdc38443d08b 347 SMART SM01329 6 341 7.6E-168 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS36235 09fbd3285b9ba8bafd58bdc38443d08b 347 Pfam PF00180 Isocitrate/isopropylmalate dehydrogenase 7 325 2.7E-89 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS36235 09fbd3285b9ba8bafd58bdc38443d08b 347 SUPERFAMILY SSF53659 4 344 4.99E-111 T 17-03-2017 SHXM_RS09475 54ee2be426bbe318bf5e045d2dd23240 134 Pfam PF01042 Endoribonuclease L-PSP 13 131 5.7E-17 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS09475 54ee2be426bbe318bf5e045d2dd23240 134 SUPERFAMILY SSF55298 1 132 1.08E-23 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS09475 54ee2be426bbe318bf5e045d2dd23240 134 Gene3D G3DSA:3.30.1330.40 2 132 3.2E-27 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 253 369 2.9E-45 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 SMART SM00825 Beta-ketoacyl synthase 1 369 1.4E-178 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 Gene3D G3DSA:3.40.47.10 1 257 4.8E-91 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 1 245 6.7E-89 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 SUPERFAMILY SSF53901 1 367 2.45E-103 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 Gene3D G3DSA:3.40.47.10 258 369 6.3E-47 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS05350 2766a777c83a2c4600d27cc080f4c3e2 369 ProSitePatterns PS00606 Beta-ketoacyl synthases active site. 158 174 - T 17-03-2017 IPR018201 Beta-ketoacyl synthase, active site SHXM_RS01410 bf0ec2ea8fa070c53a9d69c8b44c6d4e 488 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 253 260 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS01410 bf0ec2ea8fa070c53a9d69c8b44c6d4e 488 Gene3D G3DSA:3.40.605.10 15 266 5.1E-78 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS01410 bf0ec2ea8fa070c53a9d69c8b44c6d4e 488 Gene3D G3DSA:3.40.309.10 267 449 2.7E-53 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS01410 bf0ec2ea8fa070c53a9d69c8b44c6d4e 488 Pfam PF00171 Aldehyde dehydrogenase family 23 473 8.5E-139 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS01410 bf0ec2ea8fa070c53a9d69c8b44c6d4e 488 SUPERFAMILY SSF53720 14 476 3.67E-137 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS29230 6e05eb436753c8860c7a1deefe1776d3 271 SUPERFAMILY SSF74650 8 248 1.32E-40 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS29230 6e05eb436753c8860c7a1deefe1776d3 271 Pfam PF01263 Aldose 1-epimerase 23 193 1.9E-20 T 17-03-2017 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SHXM_RS29230 6e05eb436753c8860c7a1deefe1776d3 271 Gene3D G3DSA:2.70.98.10 9 244 9.7E-17 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS37175 1e98c1a1ee1996c2d51f65346b5ce7d8 210 PIRSF PIRSF000847 23 207 3.9E-43 T 17-03-2017 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668 SHXM_RS37175 1e98c1a1ee1996c2d51f65346b5ce7d8 210 Pfam PF01066 CDP-alcohol phosphatidyltransferase 26 96 1.1E-16 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS37175 1e98c1a1ee1996c2d51f65346b5ce7d8 210 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 74 96 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS37175 1e98c1a1ee1996c2d51f65346b5ce7d8 210 TIGRFAM TIGR00560 pgsA: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 26 195 8.9E-39 T 17-03-2017 IPR004570 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase GO:0008444|GO:0008654|GO:0016021 KEGG: 00564+2.7.8.5|MetaCyc: PWY-5269|MetaCyc: PWY-5668 SHXM_RS21175 601332670fadbe509df0bd3b8c6b83e4 214 Gene3D G3DSA:3.40.630.30 11 193 4.9E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21175 601332670fadbe509df0bd3b8c6b83e4 214 Pfam PF13302 Acetyltransferase (GNAT) domain 17 164 9.8E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS21175 601332670fadbe509df0bd3b8c6b83e4 214 SUPERFAMILY SSF55729 11 169 8.86E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19520 09c8a8b7c43dc3f002801806c90a62bd 338 Pfam PF09243 Mitochondrial small ribosomal subunit Rsm22 55 331 2.1E-100 T 17-03-2017 IPR015324 Ribosomal protein Rsm22, bacterial-type GO:0006412|GO:0008168 SHXM_RS19520 09c8a8b7c43dc3f002801806c90a62bd 338 Gene3D G3DSA:3.40.50.150 60 205 9.3E-10 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS19520 09c8a8b7c43dc3f002801806c90a62bd 338 SUPERFAMILY SSF53335 56 225 3.78E-14 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS49410 65017982b9ce8fd5b6ecf5b01e5610dd 411 Gene3D G3DSA:3.40.640.10 111 358 1.1E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS49410 65017982b9ce8fd5b6ecf5b01e5610dd 411 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 278 314 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS49410 65017982b9ce8fd5b6ecf5b01e5610dd 411 Pfam PF00202 Aminotransferase class-III 73 394 1.8E-66 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS49410 65017982b9ce8fd5b6ecf5b01e5610dd 411 SUPERFAMILY SSF53383 45 406 6.64E-95 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS49410 65017982b9ce8fd5b6ecf5b01e5610dd 411 Gene3D G3DSA:3.90.1150.10 363 406 3.3E-19 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS49410 65017982b9ce8fd5b6ecf5b01e5610dd 411 Gene3D G3DSA:3.90.1150.10 45 110 3.3E-19 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS48400 900acf37c46f5ba1f0de4945d4ef8353 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 89 268 3.9E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48400 900acf37c46f5ba1f0de4945d4ef8353 275 Gene3D G3DSA:1.10.3720.10 5 262 1.2E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48400 900acf37c46f5ba1f0de4945d4ef8353 275 SUPERFAMILY SSF161098 6 275 6.26E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS16930 57d6f8d787be3c5ac3c2daf2a798b8f8 629 SUPERFAMILY SSF51905 108 259 5.18E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16930 57d6f8d787be3c5ac3c2daf2a798b8f8 629 SUPERFAMILY SSF51905 11 62 5.18E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16930 57d6f8d787be3c5ac3c2daf2a798b8f8 629 Gene3D G3DSA:3.50.50.60 10 199 1.0E-5 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16930 57d6f8d787be3c5ac3c2daf2a798b8f8 629 Pfam PF13454 FAD-NAD(P)-binding 16 199 1.2E-43 T 17-03-2017 SHXM_RS12195 24ff630d1384bd5b971477b4648e4aa4 282 Pfam PF01261 Xylose isomerase-like TIM barrel 37 232 7.3E-17 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS12195 24ff630d1384bd5b971477b4648e4aa4 282 Gene3D G3DSA:3.20.20.150 27 281 2.5E-41 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS12195 24ff630d1384bd5b971477b4648e4aa4 282 SUPERFAMILY SSF51658 27 281 7.32E-53 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS31150 a843626f16cf2fd3d093342155588e48 391 SUPERFAMILY SSF55961 102 223 4.89E-19 T 17-03-2017 SHXM_RS31150 a843626f16cf2fd3d093342155588e48 391 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 110 224 1.3E-12 T 17-03-2017 IPR005031 Coenzyme Q-binding protein COQ10, START domain SHXM_RS31150 a843626f16cf2fd3d093342155588e48 391 Gene3D G3DSA:3.30.530.20 104 213 8.9E-9 T 17-03-2017 IPR023393 START-like domain SHXM_RS29245 6288f7883c80902137c74a262527ea75 474 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 28 426 8.1E-79 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS29245 6288f7883c80902137c74a262527ea75 474 Gene3D G3DSA:1.20.1250.20 276 472 5.6E-12 T 17-03-2017 SHXM_RS29245 6288f7883c80902137c74a262527ea75 474 Gene3D G3DSA:1.20.1250.20 26 208 2.6E-34 T 17-03-2017 SHXM_RS29245 6288f7883c80902137c74a262527ea75 474 SUPERFAMILY SSF103473 18 211 1.83E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS29245 6288f7883c80902137c74a262527ea75 474 SUPERFAMILY SSF103473 262 472 1.83E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS29245 6288f7883c80902137c74a262527ea75 474 Pfam PF07690 Major Facilitator Superfamily 33 424 4.9E-54 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23775 35cfd61392f9f111b18a2bf6f3366065 434 Gene3D G3DSA:3.40.190.10 166 367 6.1E-37 T 17-03-2017 SHXM_RS23775 35cfd61392f9f111b18a2bf6f3366065 434 Pfam PF01547 Bacterial extracellular solute-binding protein 56 340 6.9E-36 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS23775 35cfd61392f9f111b18a2bf6f3366065 434 SUPERFAMILY SSF53850 26 429 2.54E-75 T 17-03-2017 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 TIGRFAM TIGR00655 PurU: formyltetrahydrofolate deformylase 12 288 9.0E-103 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 SUPERFAMILY SSF55021 10 90 2.0E-18 T 17-03-2017 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 SUPERFAMILY SSF53328 93 288 1.44E-62 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PIRSF PIRSF036480 8 289 7.5E-114 T 17-03-2017 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 Gene3D G3DSA:3.30.70.260 9 89 2.3E-29 T 17-03-2017 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 Gene3D G3DSA:3.40.50.170 93 288 3.1E-56 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 Pfam PF00551 Formyl transferase 93 270 5.5E-38 T 17-03-2017 IPR002376 Formyl transferase, N-terminal GO:0009058|GO:0016742 KEGG: 00670+2.1.2.9|KEGG: 00970+2.1.2.9 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 116 143 1.5E-51 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 262 287 1.5E-51 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 13 39 1.5E-51 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 94 116 1.5E-51 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 45 57 1.5E-51 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 PRINTS PR01575 Formyltetrahydrofolate deformylase signature 240 262 1.5E-51 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS25500 1b2acdf4a3d4c6f807a29353a0554eeb 289 Hamap MF_01927 Formyltetrahydrofolate deformylase [purU]. 8 288 48.098 T 17-03-2017 IPR004810 Formyltetrahydrofolate deformylase GO:0006189|GO:0008864 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 SUPERFAMILY SSF56112 12 261 2.29E-56 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 Gene3D G3DSA:1.10.510.10 104 260 1.6E-35 T 17-03-2017 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 SMART SM00220 16 266 1.7E-37 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 Gene3D G3DSA:3.30.200.20 8 94 8.5E-11 T 17-03-2017 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 Pfam PF00069 Protein kinase domain 16 257 4.0E-31 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 SUPERFAMILY SSF50998 344 696 1.13E-22 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 134 146 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 Gene3D G3DSA:2.140.10.10 329 727 8.2E-25 T 17-03-2017 IPR027295 Quinoprotein alcohol dehydrogenase-like domain SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 22 44 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS37055 f40d20da130a0d000378ad56518c1c2a 729 Pfam PF13360 PQQ-like domain 496 705 3.7E-19 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 348 357 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 277 288 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 295 322 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 139 155 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 346 355 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 355 366 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 194 216 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00359 B-class P450 signature 91 102 1.1E-26 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 SUPERFAMILY SSF48264 31 406 1.7E-85 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 Pfam PF00067 Cytochrome P450 208 269 6.0E-6 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 Pfam PF00067 Cytochrome P450 277 378 2.7E-13 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 Gene3D G3DSA:1.10.630.10 11 406 1.7E-112 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00385 P450 superfamily signature 346 355 4.6E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00385 P450 superfamily signature 355 366 4.6E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00385 P450 superfamily signature 242 259 4.6E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37695 6504ccc9fcd7dd60262a8364046ea784 407 PRINTS PR00385 P450 superfamily signature 277 288 4.6E-5 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 Pfam PF13450 NAD(P)-binding Rossmann-like domain 9 56 6.4E-11 T 17-03-2017 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 SUPERFAMILY SSF51905 426 470 1.6E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 SUPERFAMILY SSF51905 5 302 1.6E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 Gene3D G3DSA:3.40.50.720 4 56 7.7E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 290 311 7.1E-6 T 17-03-2017 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 7.1E-6 T 17-03-2017 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 Gene3D G3DSA:3.50.50.60 211 290 1.2E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS14835 5c3c7485036cc3be7d803ce3828b81f9 473 Gene3D G3DSA:3.50.50.60 437 471 1.2E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11180 9d1e052a34d3fd7ae33af7341f385b28 384 SUPERFAMILY SSF53850 97 306 1.01E-16 T 17-03-2017 SHXM_RS11180 9d1e052a34d3fd7ae33af7341f385b28 384 Pfam PF09084 NMT1/THI5 like 99 255 5.2E-7 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS11180 9d1e052a34d3fd7ae33af7341f385b28 384 Gene3D G3DSA:3.40.190.10 190 296 2.2E-7 T 17-03-2017 SHXM_RS11215 bd1c178db428cc70d60a14fa1e343dbc 275 Gene3D G3DSA:1.10.3720.10 6 262 2.5E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11215 bd1c178db428cc70d60a14fa1e343dbc 275 SUPERFAMILY SSF161098 6 274 1.22E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11215 bd1c178db428cc70d60a14fa1e343dbc 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 87 260 1.2E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS17105 cd921afd4b68bb3908b765f1eb0add2a 602 Pfam PF00723 Glycosyl hydrolases family 15 222 591 3.4E-75 T 17-03-2017 IPR011613 Glycoside hydrolase family 15/Phosphorylase b kinase regulatory chain family Reactome: R-HSA-70221 SHXM_RS17105 cd921afd4b68bb3908b765f1eb0add2a 602 SUPERFAMILY SSF48208 196 595 9.78E-108 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS17105 cd921afd4b68bb3908b765f1eb0add2a 602 Gene3D G3DSA:1.50.10.10 218 595 5.6E-85 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 SUPERFAMILY SSF53822 64 327 1.73E-55 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 1.9E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 Gene3D G3DSA:3.40.50.2300 170 327 3.3E-41 T 17-03-2017 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 SMART SM00354 3 73 1.3E-21 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 SUPERFAMILY SSF47413 4 61 3.0E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 Pfam PF13377 Periplasmic binding protein-like domain 171 326 3.8E-32 T 17-03-2017 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 Gene3D G3DSA:3.40.50.2300 56 169 1.7E-30 T 17-03-2017 SHXM_RS15590 ec128f65bdec8926c3496790ae9909e7 331 Gene3D G3DSA:1.10.260.40 4 55 1.4E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS29265 d11965699ff4ef0dd4b31eebcc1bb09a 291 SUPERFAMILY SSF53474 14 279 1.5E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS29265 d11965699ff4ef0dd4b31eebcc1bb09a 291 Gene3D G3DSA:3.40.50.1820 17 281 4.2E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS29265 d11965699ff4ef0dd4b31eebcc1bb09a 291 Pfam PF07859 alpha/beta hydrolase fold 51 261 2.0E-10 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS22755 a3d843f8bf45fe8e192475d7efab9a7e 392 Pfam PF00150 Cellulase (glycosyl hydrolase family 5) 100 359 6.0E-31 T 17-03-2017 IPR001547 Glycoside hydrolase, family 5 GO:0004553|GO:0005975 SHXM_RS22755 a3d843f8bf45fe8e192475d7efab9a7e 392 SUPERFAMILY SSF51445 58 390 1.04E-50 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS22755 a3d843f8bf45fe8e192475d7efab9a7e 392 Gene3D G3DSA:3.20.20.80 60 390 2.7E-58 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS22755 a3d843f8bf45fe8e192475d7efab9a7e 392 ProSitePatterns PS00659 Glycosyl hydrolases family 5 signature. 211 220 - T 17-03-2017 IPR018087 Glycoside hydrolase, family 5, conserved site GO:0004553|GO:0005975 SHXM_RS15900 6b85222926cea4c082a9946f181dc28d 427 Gene3D G3DSA:1.20.1250.20 32 199 2.5E-14 T 17-03-2017 SHXM_RS15900 6b85222926cea4c082a9946f181dc28d 427 Pfam PF07690 Major Facilitator Superfamily 18 329 6.8E-14 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS15900 6b85222926cea4c082a9946f181dc28d 427 Gene3D G3DSA:1.20.1250.20 207 382 2.1E-7 T 17-03-2017 SHXM_RS15900 6b85222926cea4c082a9946f181dc28d 427 SUPERFAMILY SSF103473 13 391 1.31E-32 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS01515 d52054e68985a288d1e11cb13e26969a 228 Gene3D G3DSA:3.40.50.880 14 227 2.7E-50 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS01515 d52054e68985a288d1e11cb13e26969a 228 SUPERFAMILY SSF52317 17 228 9.38E-42 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS01515 d52054e68985a288d1e11cb13e26969a 228 Pfam PF06283 Trehalose utilisation 17 226 1.6E-43 T 17-03-2017 IPR029010 ThuA-like domain SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Gene3D G3DSA:3.40.50.300 341 453 2.5E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Gene3D G3DSA:3.40.50.300 732 781 2.5E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Gene3D G3DSA:3.40.50.300 658 693 2.5E-44 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Gene3D G3DSA:1.10.486.10 454 621 1.7E-21 T 17-03-2017 SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Pfam PF00580 UvrD/REP helicase N-terminal domain 20 326 4.7E-50 T 17-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Pfam PF13361 UvrD-like helicase C-terminal domain 603 754 1.4E-11 T 17-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Pfam PF13361 UvrD-like helicase C-terminal domain 338 490 1.4E-12 T 17-03-2017 IPR014017 UvrD-like DNA helicase, C-terminal GO:0005524|GO:0016787 SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 SUPERFAMILY SSF52540 736 782 1.48E-111 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 SUPERFAMILY SSF52540 17 489 1.48E-111 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 SUPERFAMILY SSF52540 537 695 1.48E-111 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Gene3D G3DSA:3.40.50.300 200 328 1.3E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Gene3D G3DSA:3.40.50.300 19 155 1.3E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34280 e3b2a83706b48f1949ab597e6a4bf4fd 1223 Pfam PF12705 PD-(D/E)XK nuclease superfamily 999 1151 1.1E-8 T 17-03-2017 SHXM_RS06725 1241c4f7dc1242a25861dd48482ea67f 493 Gene3D G3DSA:3.40.50.2300 114 275 1.3E-8 T 17-03-2017 SHXM_RS06725 1241c4f7dc1242a25861dd48482ea67f 493 SUPERFAMILY SSF53822 116 478 1.82E-18 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS14295 9b500db86b7fb106e47c2bdee15a2ccf 358 PIRSF PIRSF026166 8 343 3.1E-126 T 17-03-2017 IPR016833 Putative sodium bile acid cotransporter SHXM_RS14295 9b500db86b7fb106e47c2bdee15a2ccf 358 Pfam PF13593 SBF-like CPA transporter family (DUF4137) 20 325 2.7E-92 T 17-03-2017 IPR016833 Putative sodium bile acid cotransporter SHXM_RS48195 ef141f9aa0748dc94e3462a78886362d 173 SUPERFAMILY SSF46689 2 78 5.82E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 Pfam PF00902 Sec-independent protein translocase protein (TatC) 20 247 6.0E-59 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 TIGRFAM TIGR00945 tatC: twin arginine-targeting protein translocase TatC 18 252 1.2E-53 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 111 129 2.7E-36 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 179 207 2.7E-36 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 129 155 2.7E-36 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 PRINTS PR01840 Bacterial Sec-independent translocation TatC protein family signature 17 44 2.7E-36 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS15855 e9dc51fef3ebaef677b19d95634e02a1 321 Hamap MF_00902 Sec-independent protein translocase protein TatC [tatC]. 8 266 16.72 T 17-03-2017 IPR002033 Sec-independent periplasmic protein translocase TatC GO:0016021 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:2.60.40.320 195 321 1.5E-29 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:2.60.40.920 766 867 5.7E-10 T 17-03-2017 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 SUPERFAMILY SSF51445 318 635 9.18E-65 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:2.60.120.260 898 1022 5.3E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:2.60.120.260 23 194 3.6E-40 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 SUPERFAMILY SSF49303 223 321 9.21E-17 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 PRINTS PR00132 Glycosyl hydrolase family 2 signature 434 449 2.5E-9 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 PRINTS PR00132 Glycosyl hydrolase family 2 signature 134 149 2.5E-9 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 PRINTS PR00132 Glycosyl hydrolase family 2 signature 333 347 2.5E-9 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 PRINTS PR00132 Glycosyl hydrolase family 2 signature 364 382 2.5E-9 T 17-03-2017 IPR006101 Glycoside hydrolase, family 2 GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807|Reactome: R-HSA-2024096|Reactome: R-HSA-2160916|Reactome: R-HSA-2206292 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 SUPERFAMILY SSF49373 763 865 7.85E-8 T 17-03-2017 IPR008964 Invasin/intimin cell-adhesion fragments SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Pfam PF16355 Domain of unknown function (DUF4982) 654 752 2.6E-18 T 17-03-2017 IPR032311 Domain of unknown function DUF4982 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 SUPERFAMILY SSF49785 31 205 5.1E-42 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 47 201 1.8E-18 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:2.60.40.1560 640 683 2.9E-26 T 17-03-2017 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:2.60.40.1560 723 765 2.9E-26 T 17-03-2017 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Pfam PF00703 Glycosyl hydrolases family 2 216 321 2.7E-15 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Gene3D G3DSA:3.20.20.80 327 638 7.9E-65 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS03595 e837c89616c15b49324009f7c0c73f81 1036 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 329 482 1.2E-24 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS14530 e3d0013873437df4363769086233448f 412 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 257 365 3.0E-20 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS14530 e3d0013873437df4363769086233448f 412 Gene3D G3DSA:3.40.47.10 3 260 4.4E-49 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14530 e3d0013873437df4363769086233448f 412 SUPERFAMILY SSF53901 217 408 1.55E-44 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14530 e3d0013873437df4363769086233448f 412 SUPERFAMILY SSF53901 6 251 2.56E-56 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14530 e3d0013873437df4363769086233448f 412 Gene3D G3DSA:3.40.47.10 271 407 2.4E-33 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS14530 e3d0013873437df4363769086233448f 412 SMART SM00825 Beta-ketoacyl synthase 8 410 4.7E-5 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS14530 e3d0013873437df4363769086233448f 412 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 9 244 1.7E-32 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS08950 af2365321977661103361a89381e6068 100 SUPERFAMILY SSF48557 11 94 8.95E-19 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS08950 af2365321977661103361a89381e6068 100 Pfam PF10415 Fumarase C C-terminus 41 93 5.5E-20 T 17-03-2017 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS08950 af2365321977661103361a89381e6068 100 Gene3D G3DSA:1.10.40.30 52 96 1.5E-20 T 17-03-2017 SHXM_RS08950 af2365321977661103361a89381e6068 100 Gene3D G3DSA:1.20.200.10 12 51 3.1E-10 T 17-03-2017 SHXM_RS23190 c22b0b3d4bae789ffabcd7a0a959dc27 294 Gene3D G3DSA:1.10.260.40 7 79 2.3E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS23190 c22b0b3d4bae789ffabcd7a0a959dc27 294 Pfam PF13560 Helix-turn-helix domain 13 80 3.1E-11 T 17-03-2017 SHXM_RS35440 36fcba0fdeaffc5830ecf06ab2cf2e05 226 SUPERFAMILY SSF51219 24 210 1.2E-27 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS35440 36fcba0fdeaffc5830ecf06ab2cf2e05 226 Pfam PF01987 Mitochondrial biogenesis AIM24 28 209 1.1E-9 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS35440 36fcba0fdeaffc5830ecf06ab2cf2e05 226 Gene3D G3DSA:3.60.160.10 25 210 7.5E-21 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS16910 16af952623d358662a7505fa0c00ac3c 363 Gene3D G3DSA:3.20.20.30 6 352 4.5E-98 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16910 16af952623d358662a7505fa0c00ac3c 363 SUPERFAMILY SSF51679 14 351 2.88E-79 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16910 16af952623d358662a7505fa0c00ac3c 363 Pfam PF00296 Luciferase-like monooxygenase 17 264 6.6E-40 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16780 07bed48de654113c98a0c673ad690589 288 SMART SM00530 21 76 0.0057 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS16780 07bed48de654113c98a0c673ad690589 288 Pfam PF13560 Helix-turn-helix domain 18 68 1.7E-6 T 17-03-2017 SHXM_RS16780 07bed48de654113c98a0c673ad690589 288 SUPERFAMILY SSF47413 16 72 2.25E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS16780 07bed48de654113c98a0c673ad690589 288 Gene3D G3DSA:1.10.260.40 16 57 2.0E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 TIGRFAM TIGR01068 thioredoxin: thioredoxin 9 104 3.4E-30 T 17-03-2017 IPR005746 Thioredoxin GO:0006662|GO:0015035|GO:0045454 SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 PRINTS PR00421 Thioredoxin family signature 70 81 1.4E-7 T 17-03-2017 SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 PRINTS PR00421 Thioredoxin family signature 31 40 1.4E-7 T 17-03-2017 SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 PRINTS PR00421 Thioredoxin family signature 23 31 1.4E-7 T 17-03-2017 SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 ProSitePatterns PS00194 Thioredoxin family active site. 24 42 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 SUPERFAMILY SSF52833 4 104 2.65E-32 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 Gene3D G3DSA:3.40.30.10 2 103 6.9E-32 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS20490 c4483b9359e197271c635f008fedf509 146 Pfam PF00085 Thioredoxin 5 102 6.0E-27 T 17-03-2017 IPR013766 Thioredoxin domain GO:0045454 SHXM_RS20190 c419d05dc4a1e738066b4cf999f4ac47 1197 Pfam PF12500 TRSP domain C terminus to PRTase_2 644 756 5.8E-37 T 17-03-2017 IPR022537 TRSP domain SHXM_RS20190 c419d05dc4a1e738066b4cf999f4ac47 1197 Gene3D G3DSA:3.40.50.2020 242 384 6.3E-5 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS20190 c419d05dc4a1e738066b4cf999f4ac47 1197 SUPERFAMILY SSF53271 212 373 5.54E-6 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS20190 c419d05dc4a1e738066b4cf999f4ac47 1197 Pfam PF15608 PELOTA RNA binding domain 1075 1154 8.7E-34 T 17-03-2017 IPR028157 PELOTA RNA-binding domain SHXM_RS20190 c419d05dc4a1e738066b4cf999f4ac47 1197 Pfam PF11202 Phosphoribosyl transferase (PRTase) 804 1048 1.2E-103 T 17-03-2017 IPR011215 Phosphoribosyl transferase SHXM_RS20190 c419d05dc4a1e738066b4cf999f4ac47 1197 Pfam PF15609 Phosphoribosyl transferase 213 400 8.2E-70 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS22975 1d4901f00235e9e49a378a33e2176784 471 Pfam PF01425 Amidase 25 451 8.7E-101 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS22975 1d4901f00235e9e49a378a33e2176784 471 Gene3D G3DSA:3.90.1300.10 2 458 3.6E-133 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS22975 1d4901f00235e9e49a378a33e2176784 471 ProSitePatterns PS00571 Amidases signature. 155 186 - T 17-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 SHXM_RS22975 1d4901f00235e9e49a378a33e2176784 471 SUPERFAMILY SSF75304 1 457 3.27E-135 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 Gene3D G3DSA:1.20.1290.10 351 385 5.4E-30 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 Gene3D G3DSA:1.20.1290.10 209 299 5.4E-30 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 Gene3D G3DSA:1.20.1290.10 69 183 8.6E-11 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 SUPERFAMILY SSF69118 213 385 9.19E-34 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 272 305 4.1E-11 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 TIGRFAM TIGR01926 peroxid_rel: uncharacterized peroxidase-related enzyme 221 388 1.1E-42 T 17-03-2017 IPR010195 Uncharacterised peroxidase-related SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 Pfam PF02627 Carboxymuconolactone decarboxylase family 258 309 1.5E-11 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS06035 c4ce91680b1d1173ec319adeb36dafd2 401 SUPERFAMILY SSF69118 13 184 3.6E-12 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS41395 8d8624083d008bd0020256220a06a94a 487 SUPERFAMILY SSF53474 65 197 1.02E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41395 8d8624083d008bd0020256220a06a94a 487 SUPERFAMILY SSF53474 344 415 1.02E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41395 8d8624083d008bd0020256220a06a94a 487 Gene3D G3DSA:3.40.50.1820 327 416 2.1E-12 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41395 8d8624083d008bd0020256220a06a94a 487 Gene3D G3DSA:3.40.50.1820 73 194 2.1E-12 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41395 8d8624083d008bd0020256220a06a94a 487 Gene3D G3DSA:3.40.50.1820 290 291 2.1E-12 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 Pfam PF01208 Uroporphyrinogen decarboxylase (URO-D) 22 357 5.2E-130 T 17-03-2017 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 TIGRFAM TIGR01464 hemE: uroporphyrinogen decarboxylase 26 356 3.9E-124 T 17-03-2017 IPR006361 Uroporphyrinogen decarboxylase HemE GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 ProSitePatterns PS00907 Uroporphyrinogen decarboxylase signature 2. 156 172 - T 17-03-2017 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 SUPERFAMILY SSF51726 25 359 6.54E-106 T 17-03-2017 SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 Gene3D G3DSA:3.20.20.210 20 359 2.4E-145 T 17-03-2017 SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 Hamap MF_00218 Uroporphyrinogen decarboxylase [hemE]. 23 359 47.969 T 17-03-2017 IPR006361 Uroporphyrinogen decarboxylase HemE GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS38250 276eed856f437fb8fe8fa8a64d15ba7d 368 ProSitePatterns PS00906 Uroporphyrinogen decarboxylase signature 1. 39 48 - T 17-03-2017 IPR000257 Uroporphyrinogen decarboxylase (URO-D) GO:0004853|GO:0006779 KEGG: 00860+4.1.1.37|MetaCyc: PWY-5531|MetaCyc: PWY-7159|Reactome: R-HSA-189451 SHXM_RS32820 6f61f09bb815e62fbcc0812487f332c9 527 SUPERFAMILY SSF55874 363 479 5.02E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS32820 6f61f09bb815e62fbcc0812487f332c9 527 Pfam PF07730 Histidine kinase 210 275 5.3E-17 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS03620 9be230f208a70b39730abfaba866436a 201 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 16 191 3.7E-24 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS03620 9be230f208a70b39730abfaba866436a 201 Gene3D G3DSA:3.40.50.1240 21 191 4.0E-23 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS03620 9be230f208a70b39730abfaba866436a 201 SUPERFAMILY SSF53254 22 192 9.64E-29 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS14010 61b91080f1394fa3e9056b8b0f42552e 298 SUPERFAMILY SSF55729 132 207 6.95E-6 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS14010 61b91080f1394fa3e9056b8b0f42552e 298 Gene3D G3DSA:3.40.630.30 132 207 3.8E-6 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS08365 7c403bacccfa3a2f77694b1671195d4f 200 SUPERFAMILY SSF52540 11 125 2.61E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38755 8174494be5d2a9a19a11f2fb7dd81096 177 SUPERFAMILY SSF55729 52 171 5.06E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38755 8174494be5d2a9a19a11f2fb7dd81096 177 Gene3D G3DSA:3.40.630.30 28 173 1.7E-15 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38755 8174494be5d2a9a19a11f2fb7dd81096 177 Pfam PF13508 Acetyltransferase (GNAT) domain 77 167 2.9E-6 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 TIGRFAM TIGR01974 NDH_I_L: proton-translocating NADH-quinone oxidoreductase, chain L 3 625 9.1E-236 T 17-03-2017 IPR003945 NADH-plastoquinone oxidoreductase, chain 5 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 Pfam PF00361 Proton-conducting membrane transporter 135 422 1.3E-83 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 60 84 1.7E-9 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 264 286 1.7E-9 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 420 442 1.7E-9 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01435 NADH-plastoquinone oxidoreductase chain 5 signature 86 106 1.7E-9 T 17-03-2017 IPR018393 NADH-plastoquinone oxidoreductase, chain 5 subgroup GO:0008137|GO:0042773|GO:0055114 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 159 180 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 112 132 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 246 272 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 421 440 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 224 245 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 314 326 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 PRINTS PR01434 NADH-ubiquinone oxidoreductase chain 5 signature 84 109 4.5E-60 T 17-03-2017 SHXM_RS30810 d434966fd897072db8089225c51f493d 631 Pfam PF00662 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus 66 123 6.1E-25 T 17-03-2017 IPR001516 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 Pfam PF00392 Bacterial regulatory proteins, gntR family 26 83 4.1E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 Gene3D G3DSA:1.10.10.10 9 83 1.9E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 SMART SM00345 25 83 1.1E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 SMART SM00895 93 217 1.7E-15 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 SUPERFAMILY SSF46785 16 87 8.91E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 Gene3D G3DSA:1.20.120.530 86 220 3.5E-27 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 Pfam PF07729 FCD domain 93 216 1.9E-22 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS17695 a4f619c13d1e4e7d8aeb2f1b1eeef93d 230 SUPERFAMILY SSF48008 90 222 8.11E-27 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS13590 cdff52fdb9aad1ccddbc674c9b82f27f 112 SUPERFAMILY SSF47413 17 89 4.69E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13590 cdff52fdb9aad1ccddbc674c9b82f27f 112 Gene3D G3DSA:1.10.260.40 11 76 1.3E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13590 cdff52fdb9aad1ccddbc674c9b82f27f 112 Pfam PF13560 Helix-turn-helix domain 14 77 2.8E-14 T 17-03-2017 SHXM_RS13590 cdff52fdb9aad1ccddbc674c9b82f27f 112 SMART SM00530 18 74 3.8E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS42735 4822f0809c68102c77822810343d5b84 273 Pfam PF10708 Protein of unknown function (DUF2510) 9 43 4.6E-14 T 17-03-2017 IPR018929 Domain of unknown function DUF2510 SHXM_RS42735 4822f0809c68102c77822810343d5b84 273 Pfam PF03803 Scramblase 77 263 2.2E-17 T 17-03-2017 IPR005552 Scramblase SHXM_RS42735 4822f0809c68102c77822810343d5b84 273 SUPERFAMILY SSF54518 95 262 4.45E-9 T 17-03-2017 IPR025659 Tubby C-terminal-like domain SHXM_RS20335 e389140d15c5a101f777fe3bab35adbd 287 Gene3D G3DSA:3.40.50.1110 220 282 3.5E-22 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS20335 e389140d15c5a101f777fe3bab35adbd 287 Gene3D G3DSA:3.40.50.1110 47 184 3.5E-22 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS20335 e389140d15c5a101f777fe3bab35adbd 287 SUPERFAMILY SSF52266 214 282 2.6E-25 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS20335 e389140d15c5a101f777fe3bab35adbd 287 SUPERFAMILY SSF52266 46 185 2.6E-25 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS20335 e389140d15c5a101f777fe3bab35adbd 287 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 52 272 1.4E-20 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS08055 4a98914b133adff155fbf4afff82f47a 256 Gene3D G3DSA:3.40.50.150 33 226 9.1E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08055 4a98914b133adff155fbf4afff82f47a 256 SUPERFAMILY SSF53335 33 209 2.57E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08055 4a98914b133adff155fbf4afff82f47a 256 Pfam PF08241 Methyltransferase domain 54 146 6.9E-21 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 PIRSF PIRSF001100 8 242 2.3E-47 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 Pfam PF01341 Glycosyl hydrolases family 6 23 207 5.2E-47 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 PRINTS PR00733 Glycosyl hydrolase family 6 signature 45 58 1.0E-26 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 PRINTS PR00733 Glycosyl hydrolase family 6 signature 188 202 1.0E-26 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 PRINTS PR00733 Glycosyl hydrolase family 6 signature 140 153 1.0E-26 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 PRINTS PR00733 Glycosyl hydrolase family 6 signature 75 85 1.0E-26 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 PRINTS PR00733 Glycosyl hydrolase family 6 signature 164 184 1.0E-26 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 Gene3D G3DSA:3.20.20.40 22 243 1.4E-79 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 SUPERFAMILY SSF51989 22 102 2.49E-48 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS38880 affb35a0ef292c4e811054f0fcd70bf2 251 SUPERFAMILY SSF51989 138 240 2.49E-48 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 SUPERFAMILY SSF53474 5 284 3.09E-52 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 Gene3D G3DSA:3.40.50.1820 4 283 4.1E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 Pfam PF00561 alpha/beta hydrolase fold 31 271 1.5E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 58 73 7.0E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 103 116 7.0E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 117 130 7.0E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 228 242 7.0E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00412 Epoxide hydrolase signature 103 116 3.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00412 Epoxide hydrolase signature 117 130 3.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00412 Epoxide hydrolase signature 226 242 3.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS45825 5f8eddc771d86f8464a8967ed86a589c 287 PRINTS PR00412 Epoxide hydrolase signature 259 281 3.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 SUPERFAMILY SSF55486 79 206 1.16E-31 T 17-03-2017 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 167 191 7.1E-63 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 117 141 7.1E-63 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 142 166 7.1E-63 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 85 111 7.1E-63 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 PRINTS PR00787 Streptomyces extracellular neutral proteinase (M7) family signature 194 208 7.1E-63 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 PIRSF PIRSF016573 1 221 3.5E-102 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 ProDom PD016028 PROTEASE METALLOPROTEASE EXTRACELLULAR NEUTRAL SMALL METAL-BINDING ZINC HYDROLASE SNAPALYSIN ZYMOGEN 86 209 3.0E-58 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 Gene3D G3DSA:3.40.390.10 80 207 2.6E-40 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS34705 3460787bddf32363a31a34dd979dc7ff 221 Pfam PF02031 Streptomyces extracellular neutral proteinase (M7) family 78 209 4.9E-79 T 17-03-2017 IPR000013 Peptidase M7, snapalysin GO:0004222|GO:0005576|GO:0006508|GO:0008270 SHXM_RS21785 3e93adbc00c91cb91859a74e57a06457 218 Pfam PF07331 Tripartite tricarboxylate transporter TctB family 68 210 7.0E-23 T 17-03-2017 IPR009936 Protein of unknown function DUF1468 SHXM_RS39720 1262172982d924cc6455e75a6b97faac 308 SUPERFAMILY SSF54593 1 88 5.78E-7 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS39720 1262172982d924cc6455e75a6b97faac 308 SUPERFAMILY SSF54593 139 284 5.23E-27 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS39720 1262172982d924cc6455e75a6b97faac 308 Gene3D G3DSA:3.10.180.10 145 290 6.8E-37 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS39720 1262172982d924cc6455e75a6b97faac 308 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 145 254 1.2E-9 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS39720 1262172982d924cc6455e75a6b97faac 308 Gene3D G3DSA:3.10.180.10 1 102 7.8E-6 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS48705 3f6b221cda504878f71e9d63a1387d45 447 Gene3D G3DSA:1.20.1250.20 18 220 3.1E-25 T 17-03-2017 SHXM_RS48705 3f6b221cda504878f71e9d63a1387d45 447 Gene3D G3DSA:1.20.1250.20 242 430 1.5E-26 T 17-03-2017 SHXM_RS48705 3f6b221cda504878f71e9d63a1387d45 447 Pfam PF07690 Major Facilitator Superfamily 34 312 1.5E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS48705 3f6b221cda504878f71e9d63a1387d45 447 SUPERFAMILY SSF103473 17 433 1.96E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS48705 3f6b221cda504878f71e9d63a1387d45 447 ProSitePatterns PS00217 Sugar transport proteins signature 2. 129 154 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS08930 254b921f402c854c8537eb84a82c42db 103 Pfam PF13359 DDE superfamily endonuclease 1 96 2.0E-14 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS49860 adf9885a07f496768dfda3676843fda2 361 PIRSF PIRSF007313 1 359 1.6E-139 T 17-03-2017 IPR008773 Phosphonate metabolism protein PhnI GO:0019634 SHXM_RS49860 adf9885a07f496768dfda3676843fda2 361 Pfam PF05861 Bacterial phosphonate metabolism protein (PhnI) 1 347 1.0E-146 T 17-03-2017 IPR008773 Phosphonate metabolism protein PhnI GO:0019634 SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 Pfam PF12802 MarR family 44 101 2.5E-14 T 17-03-2017 SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 SUPERFAMILY SSF46785 16 144 1.16E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 ProSitePatterns PS01117 MarR-type HTH domain signature. 76 110 - T 17-03-2017 IPR023187 Transcriptional regulator MarR-type, conserved site SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 Gene3D G3DSA:1.10.10.10 10 143 5.3E-33 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 SMART SM00347 37 137 6.0E-24 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 61 77 5.5E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 78 93 5.5E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 97 113 5.5E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS25680 4a5c64447217ac15c93d95614be3f918 153 PRINTS PR00598 Bacterial regulatory protein MarR family signature 127 147 5.5E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS32515 c5aaa368852eb7b60c1f257f795032ea 267 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 4 261 1.6E-65 T 17-03-2017 SHXM_RS32515 c5aaa368852eb7b60c1f257f795032ea 267 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 6 256 7.2E-23 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS32515 c5aaa368852eb7b60c1f257f795032ea 267 Gene3D G3DSA:3.60.10.10 2 263 2.7E-87 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS32515 c5aaa368852eb7b60c1f257f795032ea 267 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 4 262 1.3E-68 T 17-03-2017 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 SHXM_RS32515 c5aaa368852eb7b60c1f257f795032ea 267 SUPERFAMILY SSF56219 2 262 1.05E-69 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS45875 2fbf6a53ebf4138798ddad89f548745b 342 Gene3D G3DSA:3.30.1780.10 4 146 1.3E-32 T 17-03-2017 IPR023401 Ornithine cyclodeaminase, N-terminal Reactome: R-HSA-71064 SHXM_RS45875 2fbf6a53ebf4138798ddad89f548745b 342 Pfam PF02423 Ornithine cyclodeaminase/mu-crystallin family 22 319 8.9E-53 T 17-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 SHXM_RS45875 2fbf6a53ebf4138798ddad89f548745b 342 Gene3D G3DSA:3.40.50.720 147 301 2.2E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45875 2fbf6a53ebf4138798ddad89f548745b 342 SUPERFAMILY SSF51735 4 332 2.09E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45875 2fbf6a53ebf4138798ddad89f548745b 342 PIRSF PIRSF001439 16 329 2.0E-51 T 17-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 SHXM_RS32315 dcebc46933cf1858d1b593f62a8eb2f6 443 Gene3D G3DSA:3.40.390.10 203 299 4.1E-8 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS32315 dcebc46933cf1858d1b593f62a8eb2f6 443 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 98 360 7.8E-46 T 17-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 SHXM_RS32315 dcebc46933cf1858d1b593f62a8eb2f6 443 SUPERFAMILY SSF55486 219 298 6.41E-6 T 17-03-2017 SHXM_RS48315 23be2d96f01b02ea3909741c5146708d 322 SUPERFAMILY SSF53067 13 312 2.04E-60 T 17-03-2017 SHXM_RS48315 23be2d96f01b02ea3909741c5146708d 322 Pfam PF00480 ROK family 14 309 8.6E-68 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS48315 23be2d96f01b02ea3909741c5146708d 322 Gene3D G3DSA:3.30.420.40 151 292 2.1E-53 T 17-03-2017 SHXM_RS48315 23be2d96f01b02ea3909741c5146708d 322 Gene3D G3DSA:3.30.420.40 10 150 7.2E-39 T 17-03-2017 SHXM_RS24165 3cddeb2da33940771beb4d2e71df2a4e 307 TIGRFAM TIGR01297 CDF: cation diffusion facilitator family transporter 8 288 1.0E-40 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS24165 3cddeb2da33940771beb4d2e71df2a4e 307 Gene3D G3DSA:3.30.70.1350 220 298 1.4E-6 T 17-03-2017 IPR027470 Cation efflux protein, cytoplasmic domain SHXM_RS24165 3cddeb2da33940771beb4d2e71df2a4e 307 Pfam PF01545 Cation efflux family 11 218 1.4E-34 T 17-03-2017 IPR002524 Cation efflux protein GO:0006812|GO:0008324|GO:0016021|GO:0055085 SHXM_RS24165 3cddeb2da33940771beb4d2e71df2a4e 307 Gene3D G3DSA:1.20.1510.10 8 218 1.9E-33 T 17-03-2017 IPR027469 Cation efflux protein transmembrane domain SHXM_RS24165 3cddeb2da33940771beb4d2e71df2a4e 307 SUPERFAMILY SSF161111 6 219 4.71E-39 T 17-03-2017 SHXM_RS24165 3cddeb2da33940771beb4d2e71df2a4e 307 SUPERFAMILY SSF160240 222 295 2.88E-8 T 17-03-2017 SHXM_RS30700 f079d2ec6d364338774e04d6b384089b 148 SUPERFAMILY SSF51182 8 147 5.94E-52 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS30700 f079d2ec6d364338774e04d6b384089b 148 Gene3D G3DSA:2.60.120.10 10 147 1.9E-52 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS30700 f079d2ec6d364338774e04d6b384089b 148 Pfam PF06172 Cupin superfamily (DUF985) 11 145 5.4E-47 T 17-03-2017 IPR009327 Cupin domain of unknown function DUF985 SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 Pfam PF00753 Metallo-beta-lactamase superfamily 20 121 8.0E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 Hamap MF_01818 Ribonuclease BN [rbn]. 4 302 31.089 T 17-03-2017 IPR013471 Ribonuclease Z/BN GO:0016891|GO:0042779 SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 Gene3D G3DSA:3.60.15.10 193 305 1.6E-70 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 Gene3D G3DSA:3.60.15.10 5 158 1.6E-70 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 SMART SM00849 21 216 0.0083 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 Pfam PF12706 Beta-lactamase superfamily domain 199 268 1.0E-10 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS21265 573ed28e6d267a6e992d79740f879ce0 306 SUPERFAMILY SSF56281 5 301 2.75E-64 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS04730 b729c81b6216ee5b3e333abbeac96fde 316 SUPERFAMILY SSF161098 79 304 2.22E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04730 b729c81b6216ee5b3e333abbeac96fde 316 Gene3D G3DSA:1.10.3720.10 86 314 1.3E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04730 b729c81b6216ee5b3e333abbeac96fde 316 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 110 305 2.1E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20540 a70fd466e46b1d5d4dbf14a2137fa0de 512 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 84 235 8.0E-8 T 17-03-2017 SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 PRINTS PR00069 Aldo-keto reductase signature 43 67 3.6E-15 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 PRINTS PR00069 Aldo-keto reductase signature 129 146 3.6E-15 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 PRINTS PR00069 Aldo-keto reductase signature 203 227 3.6E-15 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 PRINTS PR00069 Aldo-keto reductase signature 99 117 3.6E-15 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 SUPERFAMILY SSF51430 10 270 8.64E-85 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 Gene3D G3DSA:3.20.20.100 11 268 1.2E-81 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS04320 ac7604991fbe2e40d66623e4d69617cd 280 Pfam PF00248 Aldo/keto reductase family 19 266 1.1E-57 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS08355 b4dd9d8fe34d147315bd0360e40717df 288 Pfam PF13560 Helix-turn-helix domain 18 77 6.6E-10 T 17-03-2017 SHXM_RS08355 b4dd9d8fe34d147315bd0360e40717df 288 SUPERFAMILY SSF47413 13 72 3.94E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS08355 b4dd9d8fe34d147315bd0360e40717df 288 SMART SM00530 21 76 7.1E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS08355 b4dd9d8fe34d147315bd0360e40717df 288 Gene3D G3DSA:1.10.260.40 15 72 2.6E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS45270 b2dbd7ccba07ac490b82ce8adc24ec6e 683 TIGRFAM TIGR02243 TIGR02243: putative baseplate assembly protein 43 647 1.9E-65 T 17-03-2017 IPR011749 Conserved hypothetical protein CHP02243 SHXM_RS45270 b2dbd7ccba07ac490b82ce8adc24ec6e 683 Pfam PF04865 Baseplate J-like protein 430 609 3.1E-9 T 17-03-2017 IPR006949 Baseplate protein J-like SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 Pfam PF03632 Glycosyl hydrolase family 65 central catalytic domain 327 696 1.2E-140 T 17-03-2017 IPR005195 Glycoside hydrolase, family 65, central catalytic GO:0003824|GO:0005975 SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 Gene3D G3DSA:2.70.98.40 7 270 6.6E-73 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 SUPERFAMILY SSF74650 7 270 5.02E-64 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 Pfam PF03636 Glycosyl hydrolase family 65, N-terminal domain 22 270 2.0E-59 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 Pfam PF03633 Glycosyl hydrolase family 65, C-terminal domain 700 750 5.0E-16 T 17-03-2017 IPR005194 Glycoside hydrolase family 65, C-terminal SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 Gene3D G3DSA:1.50.10.10 321 682 2.7E-131 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 SUPERFAMILY SSF48208 279 748 2.21E-123 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 PIRSF PIRSF036289 1 763 2.2E-219 T 17-03-2017 IPR017045 Maltose phosphorylase/glycosyl hydrolase/vacuolar acid trehalase SHXM_RS46230 bb843ce0dc9128429f2249b9c77bc35b 781 Gene3D G3DSA:2.60.420.10 683 752 2.8E-23 T 17-03-2017 SHXM_RS03250 2edf85207944eaefe730620f6cf30ee4 207 Pfam PF00440 Bacterial regulatory proteins, tetR family 1 47 3.4E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03250 2edf85207944eaefe730620f6cf30ee4 207 SUPERFAMILY SSF46689 2 67 6.16E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03250 2edf85207944eaefe730620f6cf30ee4 207 Gene3D G3DSA:1.10.357.10 123 199 1.8E-19 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03250 2edf85207944eaefe730620f6cf30ee4 207 Gene3D G3DSA:1.10.357.10 2 88 1.8E-19 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS13010 691d7a45c34a868c2610f8fec356144c 189 Pfam PF10400 Virulence activator alpha C-term 92 180 9.9E-20 T 17-03-2017 IPR018309 Transcription regulator PadR, C-terminal SHXM_RS13010 691d7a45c34a868c2610f8fec356144c 189 Gene3D G3DSA:1.10.10.10 1 85 4.7E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13010 691d7a45c34a868c2610f8fec356144c 189 SUPERFAMILY SSF46785 3 181 4.02E-38 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13010 691d7a45c34a868c2610f8fec356144c 189 Pfam PF03551 Transcriptional regulator PadR-like family 7 81 1.2E-13 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 Pfam PF00072 Response regulator receiver domain 5 116 8.8E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 SMART SM00421 151 208 9.2E-24 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 Gene3D G3DSA:1.10.10.10 123 215 3.1E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 SUPERFAMILY SSF52172 3 132 1.99E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 SMART SM00448 3 115 1.6E-32 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 Gene3D G3DSA:3.40.50.2300 2 122 7.2E-39 T 17-03-2017 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 ProSitePatterns PS00622 LuxR-type HTH domain signature. 168 195 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 SUPERFAMILY SSF46894 135 214 1.67E-22 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 Pfam PF00196 Bacterial regulatory proteins, luxR family 153 208 1.3E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 184 196 9.8E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 168 184 9.8E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS05545 88a10b91380c08ae21db21101216633c 236 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 154 168 9.8E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS03720 409ba0d648e1de6b9b6f265e12a54e19 147 Pfam PF13577 SnoaL-like domain 2 115 4.4E-12 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS03720 409ba0d648e1de6b9b6f265e12a54e19 147 SUPERFAMILY SSF54427 1 142 4.78E-22 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS03720 409ba0d648e1de6b9b6f265e12a54e19 147 Gene3D G3DSA:3.10.450.50 2 138 5.8E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS15605 af4758071131da67c012eea0170ed447 326 Gene3D G3DSA:3.30.360.10 132 306 3.0E-33 T 17-03-2017 SHXM_RS15605 af4758071131da67c012eea0170ed447 326 SUPERFAMILY SSF51735 3 136 1.25E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15605 af4758071131da67c012eea0170ed447 326 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 4 122 1.5E-24 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS15605 af4758071131da67c012eea0170ed447 326 SUPERFAMILY SSF55347 159 284 5.36E-7 T 17-03-2017 SHXM_RS15605 af4758071131da67c012eea0170ed447 326 Gene3D G3DSA:3.40.50.720 3 131 8.6E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37815 79a399aebaf4f62672ca4323cea41572 70 SMART SM00923 3 53 8.4E-32 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS37815 79a399aebaf4f62672ca4323cea41572 70 SUPERFAMILY SSF160582 1 68 7.06E-32 T 17-03-2017 SHXM_RS37815 79a399aebaf4f62672ca4323cea41572 70 Pfam PF03621 MbtH-like protein 1 53 5.6E-29 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS37815 79a399aebaf4f62672ca4323cea41572 70 Gene3D G3DSA:3.90.820.10 10 68 7.8E-33 T 17-03-2017 SHXM_RS41625 4b861536f95e534ceb4bf52446ecd900 172 Gene3D G3DSA:2.60.120.10 38 169 4.4E-28 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS41625 4b861536f95e534ceb4bf52446ecd900 172 Pfam PF07883 Cupin domain 59 127 1.3E-14 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS41625 4b861536f95e534ceb4bf52446ecd900 172 SUPERFAMILY SSF51182 8 142 3.05E-28 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS25915 415d6c801195bbe38f9149ec711caa68 185 SUPERFAMILY SSF50475 21 184 2.36E-41 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS25915 415d6c801195bbe38f9149ec711caa68 185 Pfam PF01613 Flavin reductase like domain 30 184 4.0E-37 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS25915 415d6c801195bbe38f9149ec711caa68 185 Gene3D G3DSA:2.30.110.10 24 185 2.2E-49 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS25915 415d6c801195bbe38f9149ec711caa68 185 SMART SM00903 29 183 9.2E-49 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 ProSitePatterns PS00067 3-hydroxyacyl-CoA dehydrogenase signature. 183 208 - T 17-03-2017 IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 4 183 1.2E-69 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 Gene3D G3DSA:1.10.1040.10 188 282 1.2E-30 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 Gene3D G3DSA:3.40.50.720 3 187 1.2E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 SUPERFAMILY SSF48179 186 282 2.04E-27 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 PIRSF PIRSF000105 1 282 3.6E-93 T 17-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 186 282 5.6E-31 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS35310 5e86ce6bd2228a753954a2efc262073b 282 SUPERFAMILY SSF51735 3 182 2.02E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08810 4df5a44e4cefc7456e9534c228064a55 410 Pfam PF13006 Insertion element 4 transposase N-terminal 17 115 3.2E-34 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS08810 4df5a44e4cefc7456e9534c228064a55 410 SUPERFAMILY SSF53098 92 390 5.46E-26 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS08810 4df5a44e4cefc7456e9534c228064a55 410 Pfam PF01609 Transposase DDE domain 136 350 8.2E-17 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS21380 0d7760ade6f316df2ca30b9a42d1a073 260 PIRSF PIRSF006648 1 259 5.0E-66 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS21380 0d7760ade6f316df2ca30b9a42d1a073 260 Pfam PF01061 ABC-2 type transporter 12 222 4.5E-26 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS25670 e470baa8e2729882493ce055ed2e6015 192 Gene3D G3DSA:3.90.1140.10 1 191 5.7E-53 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS25670 e470baa8e2729882493ce055ed2e6015 192 SUPERFAMILY SSF55144 1 191 6.63E-38 T 17-03-2017 IPR009097 RNA ligase/cyclic nucleotide phosphodiesterase SHXM_RS25670 e470baa8e2729882493ce055ed2e6015 192 Hamap MF_01940 RNA 2',3'-cyclic phosphodiesterase [thpR]. 1 190 21.998 T 17-03-2017 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 SHXM_RS25670 e470baa8e2729882493ce055ed2e6015 192 Pfam PF13563 2'-5' RNA ligase superfamily 16 168 2.2E-16 T 17-03-2017 SHXM_RS25670 e470baa8e2729882493ce055ed2e6015 192 TIGRFAM TIGR02258 2_5_ligase: 2'-5' RNA ligase 1 188 3.0E-32 T 17-03-2017 IPR004175 RNA 2',3'-cyclic phosphodiesterase GO:0004113|GO:0008664 SHXM_RS08205 1668712b7303ae7acd5dc06c195f37c6 401 Pfam PF13088 BNR repeat-like domain 48 379 3.9E-67 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS08205 1668712b7303ae7acd5dc06c195f37c6 401 SUPERFAMILY SSF50939 34 277 5.89E-58 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS08205 1668712b7303ae7acd5dc06c195f37c6 401 SUPERFAMILY SSF50939 317 398 5.89E-58 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS08205 1668712b7303ae7acd5dc06c195f37c6 401 Gene3D G3DSA:2.120.10.10 33 281 3.1E-70 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS08205 1668712b7303ae7acd5dc06c195f37c6 401 Gene3D G3DSA:2.120.10.10 319 398 3.1E-70 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS35555 d1e62c3ab64db28de5d42f36ba95d14f 417 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 169 321 6.3E-47 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS35555 d1e62c3ab64db28de5d42f36ba95d14f 417 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 169 321 1.2E-43 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 ProSitePatterns PS00132 Zinc carboxypeptidases, zinc-binding region 1 signature. 176 198 - T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 Gene3D G3DSA:3.40.630.10 130 404 5.0E-73 T 17-03-2017 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 SMART SM00631 123 412 6.5E-73 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 SUPERFAMILY SSF53187 131 406 5.94E-65 T 17-03-2017 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 Pfam PF05547 Immune inhibitor A peptidase M6 743 917 4.0E-11 T 17-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 Pfam PF00246 Zinc carboxypeptidase 135 395 9.7E-59 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 176 190 7.1E-8 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 316 329 7.1E-8 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 149 161 7.1E-8 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS17930 3fe378a4daa86e054dd943cc16d2d339 988 PRINTS PR00765 Carboxypeptidase A metalloprotease (M14) family signature 262 270 7.1E-8 T 17-03-2017 IPR000834 Peptidase M14, carboxypeptidase A GO:0004181|GO:0006508|GO:0008270 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 ProSitePatterns PS00895 3-hydroxyisobutyrate dehydrogenase signature. 13 26 - T 17-03-2017 IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 Gene3D G3DSA:1.10.1040.10 172 297 6.0E-39 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 TIGRFAM TIGR01505 tartro_sem_red: 2-hydroxy-3-oxopropionate reductase 11 299 7.1E-123 T 17-03-2017 IPR006398 2-hydroxy-3-oxopropionate reductase GO:0008679|GO:0046487|GO:0055114 KEGG: 00630+1.1.1.60 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 SUPERFAMILY SSF51735 9 169 3.12E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12190 242537a99a718945d1822567e585d10e 301 Gene3D G3DSA:3.40.50.720 7 170 1.1E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12190 242537a99a718945d1822567e585d10e 301 SUPERFAMILY SSF48179 170 298 8.62E-36 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 PIRSF PIRSF000103 3 301 1.7E-81 T 17-03-2017 IPR015815 3-hydroxyisobutyrate dehydrogenase-related GO:0016491|GO:0055114 Reactome: R-HSA-70895 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 Pfam PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase 10 169 9.8E-51 T 17-03-2017 IPR006115 6-phosphogluconate dehydrogenase, NADP-binding GO:0004616|GO:0055114 SHXM_RS12190 242537a99a718945d1822567e585d10e 301 Pfam PF14833 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 172 290 3.6E-37 T 17-03-2017 IPR029154 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain GO:0051287 SHXM_RS41315 3738c0f7b1c48960efc57eb447ed780b 247 SUPERFAMILY SSF50891 104 231 3.75E-27 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS41315 3738c0f7b1c48960efc57eb447ed780b 247 Gene3D G3DSA:3.30.1360.40 10 75 6.6E-11 T 17-03-2017 IPR024946 Arginine repressor C-terminal-like domain SHXM_RS41315 3738c0f7b1c48960efc57eb447ed780b 247 SMART SM00796 9 216 9.3E-21 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS41315 3738c0f7b1c48960efc57eb447ed780b 247 Pfam PF02682 Allophanate hydrolase subunit 1 10 213 9.0E-40 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS41315 3738c0f7b1c48960efc57eb447ed780b 247 Gene3D G3DSA:2.40.100.10 103 232 6.8E-30 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS41315 3738c0f7b1c48960efc57eb447ed780b 247 SUPERFAMILY SSF160467 11 107 1.83E-9 T 17-03-2017 SHXM_RS25820 76b4fc22b75b3df9c11977683c6f07a0 425 Pfam PF07690 Major Facilitator Superfamily 22 346 7.4E-41 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS25820 76b4fc22b75b3df9c11977683c6f07a0 425 Gene3D G3DSA:1.20.1250.20 208 395 5.1E-18 T 17-03-2017 SHXM_RS25820 76b4fc22b75b3df9c11977683c6f07a0 425 Gene3D G3DSA:1.20.1250.20 18 196 1.5E-27 T 17-03-2017 SHXM_RS25820 76b4fc22b75b3df9c11977683c6f07a0 425 SUPERFAMILY SSF103473 9 395 2.62E-58 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 Pfam PF06968 Biotin and Thiamin Synthesis associated domain 232 321 6.9E-15 T 17-03-2017 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 SMART SM00876 232 322 1.6E-34 T 17-03-2017 IPR010722 Biotin and thiamin synthesis-associated domain KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 Hamap MF_01694 Biotin synthase [bioB]. 15 323 39.751 T 17-03-2017 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 SMART SM00729 55 261 7.1E-34 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 Pfam PF04055 Radical SAM superfamily 65 220 5.3E-12 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 SUPERFAMILY SSF102114 16 321 1.7E-74 T 17-03-2017 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 Gene3D G3DSA:3.20.20.70 16 322 3.6E-86 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS08535 f7cb0478c11e90af805118a5e27f935c 406 TIGRFAM TIGR00433 bioB: biotin synthase 28 321 4.5E-113 T 17-03-2017 IPR002684 Biotin synthase/Biotin biosynthesis bifunctional protein BioAB GO:0004076|GO:0009102 KEGG: 00780+2.8.1.6|MetaCyc: PWY-7380 SHXM_RS11045 84a8c02bd74d603572f1aca16a533b31 160 Pfam PF14102 Capsule biosynthesis CapC 17 133 1.6E-31 T 17-03-2017 IPR008338 Capsule biosynthesis protein CapC GO:0016020|GO:0045227 SHXM_RS11045 84a8c02bd74d603572f1aca16a533b31 160 PRINTS PR01759 Capsule biosynthesis protein CapC signature 25 42 5.2E-6 T 17-03-2017 IPR008338 Capsule biosynthesis protein CapC GO:0016020|GO:0045227 SHXM_RS11045 84a8c02bd74d603572f1aca16a533b31 160 PRINTS PR01759 Capsule biosynthesis protein CapC signature 71 85 5.2E-6 T 17-03-2017 IPR008338 Capsule biosynthesis protein CapC GO:0016020|GO:0045227 SHXM_RS06580 bab739c3f06c63b20affd7c3f8152d04 251 SUPERFAMILY SSF53474 8 247 1.1E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06580 bab739c3f06c63b20affd7c3f8152d04 251 SMART SM00824 Thioesterase 26 247 2.0E-5 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS06580 bab739c3f06c63b20affd7c3f8152d04 251 Gene3D G3DSA:3.40.50.1820 17 248 2.2E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06580 bab739c3f06c63b20affd7c3f8152d04 251 Pfam PF00975 Thioesterase domain 24 245 2.0E-54 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS26685 148f559dc6f0047f0269d6ae8d2443e4 399 SUPERFAMILY SSF103473 19 390 3.14E-41 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS26685 148f559dc6f0047f0269d6ae8d2443e4 399 Pfam PF07690 Major Facilitator Superfamily 35 264 5.6E-18 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS26685 148f559dc6f0047f0269d6ae8d2443e4 399 ProSitePatterns PS00216 Sugar transport proteins signature 1. 74 90 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS26685 148f559dc6f0047f0269d6ae8d2443e4 399 Gene3D G3DSA:1.20.1250.20 219 397 1.1E-11 T 17-03-2017 SHXM_RS26685 148f559dc6f0047f0269d6ae8d2443e4 399 Gene3D G3DSA:1.20.1250.20 22 192 1.3E-21 T 17-03-2017 SHXM_RS37010 57b9e01eddca61a4fe3d9ea5650df2a3 124 Gene3D G3DSA:1.10.287.1060 4 98 1.6E-10 T 17-03-2017 SHXM_RS37010 57b9e01eddca61a4fe3d9ea5650df2a3 124 SUPERFAMILY SSF140453 10 97 2.49E-12 T 17-03-2017 IPR010310 Type VII secretion system ESAT-6-like SHXM_RS37010 57b9e01eddca61a4fe3d9ea5650df2a3 124 Pfam PF06013 Proteins of 100 residues with WXG 11 79 2.3E-6 T 17-03-2017 IPR010310 Type VII secretion system ESAT-6-like SHXM_RS28640 6d0ff7d478b6eb95e3d439890017aa81 404 SMART SM00530 12 68 4.7E-11 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS28640 6d0ff7d478b6eb95e3d439890017aa81 404 Pfam PF13560 Helix-turn-helix domain 9 66 9.7E-12 T 17-03-2017 SHXM_RS28640 6d0ff7d478b6eb95e3d439890017aa81 404 SUPERFAMILY SSF47413 7 71 4.5E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28640 6d0ff7d478b6eb95e3d439890017aa81 404 Gene3D G3DSA:1.25.40.10 145 358 2.0E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS28640 6d0ff7d478b6eb95e3d439890017aa81 404 Gene3D G3DSA:1.10.260.40 7 68 1.7E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28640 6d0ff7d478b6eb95e3d439890017aa81 404 SUPERFAMILY SSF48452 162 279 4.74E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS09670 59628b0c44f90e7f8401ec9a11e54439 172 Gene3D G3DSA:3.40.630.30 9 165 5.3E-31 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS09670 59628b0c44f90e7f8401ec9a11e54439 172 SUPERFAMILY SSF55729 9 163 1.84E-24 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS09670 59628b0c44f90e7f8401ec9a11e54439 172 Pfam PF13302 Acetyltransferase (GNAT) domain 13 153 1.2E-21 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 TIGRFAM TIGR00186 rRNA_methyl_3: RNA methyltransferase, TrmH family, group 3 72 315 1.0E-57 T 17-03-2017 IPR004441 RNA methyltransferase TrmH family GO:0006396|GO:0008173 SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 Pfam PF08032 RNA 2'-O ribose methyltransferase substrate binding 74 151 8.5E-20 T 17-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 SUPERFAMILY SSF75217 139 315 3.53E-42 T 17-03-2017 IPR029028 Alpha/beta knot methyltransferases SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 Pfam PF00588 SpoU rRNA Methylase family 168 309 5.3E-32 T 17-03-2017 IPR001537 tRNA/rRNA methyltransferase, SpoU type GO:0003723|GO:0006396|GO:0008173 SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 SMART SM00967 74 151 8.1E-21 T 17-03-2017 IPR013123 RNA 2-O ribose methyltransferase, substrate binding GO:0008168 SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 Gene3D G3DSA:3.40.1280.10 163 315 8.8E-48 T 17-03-2017 IPR029026 tRNA (guanine-N1-)-methyltransferase, N-terminal SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 Gene3D G3DSA:3.30.1330.30 70 147 3.9E-20 T 17-03-2017 IPR029064 50S ribosomal protein L30e-like SHXM_RS26005 f3f71ef1f0216cfd43a5b8bd54633e57 316 SUPERFAMILY SSF55315 69 148 8.0E-16 T 17-03-2017 IPR029064 50S ribosomal protein L30e-like SHXM_RS27610 fbf6206ab7e047399b925066ec549134 254 Pfam PF13581 Histidine kinase-like ATPase domain 46 159 1.0E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27610 fbf6206ab7e047399b925066ec549134 254 SUPERFAMILY SSF55874 68 166 5.59E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27610 fbf6206ab7e047399b925066ec549134 254 Gene3D G3DSA:3.30.565.10 48 161 1.3E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS02335 879532ff75e97a4642681555e9a36a96 253 Pfam PF02678 Pirin 14 129 1.8E-30 T 17-03-2017 IPR003829 Pirin, N-terminal domain SHXM_RS02335 879532ff75e97a4642681555e9a36a96 253 Gene3D G3DSA:2.60.120.10 7 247 1.0E-56 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS02335 879532ff75e97a4642681555e9a36a96 253 SUPERFAMILY SSF51182 6 246 4.46E-55 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS02335 879532ff75e97a4642681555e9a36a96 253 PIRSF PIRSF006232 2 250 2.7E-44 T 17-03-2017 IPR012093 Pirin SHXM_RS25200 be6189a62719c5161212cb954fd304ca 325 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 43 314 2.3E-45 T 17-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SHXM_RS25200 be6189a62719c5161212cb954fd304ca 325 SUPERFAMILY SSF53850 40 325 7.21E-54 T 17-03-2017 SHXM_RS25200 be6189a62719c5161212cb954fd304ca 325 Gene3D G3DSA:3.40.190.10 266 325 4.2E-21 T 17-03-2017 SHXM_RS25200 be6189a62719c5161212cb954fd304ca 325 Gene3D G3DSA:3.40.190.10 40 124 4.2E-21 T 17-03-2017 SHXM_RS25200 be6189a62719c5161212cb954fd304ca 325 Gene3D G3DSA:3.40.190.100 128 265 1.3E-22 T 17-03-2017 SHXM_RS17390 bcdce378b9854891abb7103c6ba0d9da 231 Pfam PF07947 YhhN-like protein 37 213 9.7E-31 T 17-03-2017 IPR012506 YhhN-like GO:0016021 SHXM_RS28250 b91fc2c33735bfd2888a28a88be1f87f 490 SUPERFAMILY SSF56601 101 486 5.98E-85 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS28250 b91fc2c33735bfd2888a28a88be1f87f 490 Gene3D G3DSA:3.40.710.10 144 487 7.7E-93 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS28250 b91fc2c33735bfd2888a28a88be1f87f 490 Gene3D G3DSA:3.90.1310.10 74 143 2.3E-5 T 17-03-2017 SHXM_RS28250 b91fc2c33735bfd2888a28a88be1f87f 490 Pfam PF00905 Penicillin binding protein transpeptidase domain 156 481 1.1E-68 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS37255 57e3faab96b064f919c12c70ad5f60a5 180 Pfam PF05995 Cysteine dioxygenase type I 20 163 6.5E-44 T 17-03-2017 IPR010300 Cysteine dioxygenase type I GO:0005506|GO:0016702|GO:0055114 KEGG: 00270+1.13.11.20|KEGG: 00430+1.13.11.20|MetaCyc: PWY-5331|Reactome: R-HSA-1614558 SHXM_RS37255 57e3faab96b064f919c12c70ad5f60a5 180 SUPERFAMILY SSF51182 17 170 4.88E-31 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS37255 57e3faab96b064f919c12c70ad5f60a5 180 Gene3D G3DSA:2.60.120.10 44 166 1.6E-18 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS45125 46ae3e14cdc4c94b4c994f94c80100d6 190 Pfam PF08241 Methyltransferase domain 39 134 3.8E-20 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS45125 46ae3e14cdc4c94b4c994f94c80100d6 190 SUPERFAMILY SSF53335 1 180 1.04E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45125 46ae3e14cdc4c94b4c994f94c80100d6 190 Gene3D G3DSA:3.40.50.150 1 181 4.9E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16090 c80e56e41f0829737c58f2b56bd0d858 326 Gene3D G3DSA:3.20.20.100 9 320 1.2E-89 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS16090 c80e56e41f0829737c58f2b56bd0d858 326 Pfam PF00248 Aldo/keto reductase family 15 311 1.9E-60 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS16090 c80e56e41f0829737c58f2b56bd0d858 326 PRINTS PR00069 Aldo-keto reductase signature 104 122 5.6E-5 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS16090 c80e56e41f0829737c58f2b56bd0d858 326 PRINTS PR00069 Aldo-keto reductase signature 135 152 5.6E-5 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS16090 c80e56e41f0829737c58f2b56bd0d858 326 SUPERFAMILY SSF51430 1 315 8.9E-89 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS16090 c80e56e41f0829737c58f2b56bd0d858 326 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 135 152 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS13340 31247d74f80d28e96c111023cc0eadcd 316 TIGRFAM TIGR03465 HpnD: squalene synthase HpnD 22 299 1.2E-92 T 17-03-2017 IPR017828 Squalene/phytoene synthase HpnD GO:0016117|GO:0016767 SHXM_RS13340 31247d74f80d28e96c111023cc0eadcd 316 SUPERFAMILY SSF48576 14 302 1.46E-72 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13340 31247d74f80d28e96c111023cc0eadcd 316 Pfam PF00494 Squalene/phytoene synthase 24 287 5.7E-71 T 17-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 SHXM_RS13340 31247d74f80d28e96c111023cc0eadcd 316 Gene3D G3DSA:1.10.600.10 12 303 4.5E-80 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13340 31247d74f80d28e96c111023cc0eadcd 316 ProSitePatterns PS01045 Squalene and phytoene synthases signature 2. 176 201 - T 17-03-2017 IPR019845 Squalene/phytoene synthase, conserved site GO:0016765 Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS13340 31247d74f80d28e96c111023cc0eadcd 316 ProSitePatterns PS01044 Squalene and phytoene synthases signature 1. 137 152 - T 17-03-2017 IPR019845 Squalene/phytoene synthase, conserved site GO:0016765 Reactome: R-HSA-191273|Reactome: R-HSA-1989781|Reactome: R-HSA-2426168 SHXM_RS08220 45e757ec65e48b06fd1d66a405a847a6 274 Pfam PF00005 ABC transporter 22 180 2.9E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS08220 45e757ec65e48b06fd1d66a405a847a6 274 SUPERFAMILY SSF52540 1 251 4.57E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08220 45e757ec65e48b06fd1d66a405a847a6 274 Gene3D G3DSA:3.40.50.300 2 257 2.4E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08220 45e757ec65e48b06fd1d66a405a847a6 274 ProSitePatterns PS00211 ABC transporters family signature. 152 166 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS08220 45e757ec65e48b06fd1d66a405a847a6 274 SMART SM00382 30 229 1.1E-16 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12625 ede06231217ec40b03fc59c1c2bed24e 123 Gene3D G3DSA:3.10.180.10 8 120 1.2E-11 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS12625 ede06231217ec40b03fc59c1c2bed24e 123 SUPERFAMILY SSF54593 10 120 2.55E-14 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS47740 15c82a2c8e27e74ea56f477d060168e3 240 Pfam PF13701 Transposase DDE domain group 1 100 237 1.8E-29 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS47740 15c82a2c8e27e74ea56f477d060168e3 240 Pfam PF13701 Transposase DDE domain group 1 1 96 1.2E-12 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS43190 c604554db1679906b1d88b0fd30a35d3 305 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 295 3.2E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43190 c604554db1679906b1d88b0fd30a35d3 305 Gene3D G3DSA:1.10.3720.10 21 292 6.3E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43190 c604554db1679906b1d88b0fd30a35d3 305 SUPERFAMILY SSF161098 25 305 1.96E-67 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 Gene3D G3DSA:1.20.1250.20 33 206 5.7E-28 T 17-03-2017 SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 Pfam PF07690 Major Facilitator Superfamily 37 427 4.0E-48 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 SUPERFAMILY SSF103473 471 500 8.5E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 SUPERFAMILY SSF103473 265 437 8.5E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 SUPERFAMILY SSF103473 21 215 8.5E-63 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 32 437 6.6E-78 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 Gene3D G3DSA:1.20.1250.20 469 502 9.6E-16 T 17-03-2017 SHXM_RS23520 fc20bd14030b08fe17123ce60fd8379a 513 Gene3D G3DSA:1.20.1250.20 282 435 9.6E-16 T 17-03-2017 SHXM_RS45740 8ec52100601950acd2ed25547dfbec72 502 Gene3D G3DSA:3.90.76.10 47 184 4.3E-26 T 17-03-2017 SHXM_RS45740 8ec52100601950acd2ed25547dfbec72 502 Gene3D G3DSA:3.40.190.10 185 291 2.6E-25 T 17-03-2017 SHXM_RS45740 8ec52100601950acd2ed25547dfbec72 502 SUPERFAMILY SSF53850 31 483 3.16E-89 T 17-03-2017 SHXM_RS45740 8ec52100601950acd2ed25547dfbec72 502 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 76 410 9.1E-69 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS45740 8ec52100601950acd2ed25547dfbec72 502 Gene3D G3DSA:3.10.105.10 292 467 2.9E-36 T 17-03-2017 SHXM_RS45740 8ec52100601950acd2ed25547dfbec72 502 PIRSF PIRSF002741 1 468 3.2E-64 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS31580 eac0ae9af020441ad2e510e40dcda06c 375 SUPERFAMILY SSF51412 12 77 3.36E-69 T 17-03-2017 SHXM_RS31580 eac0ae9af020441ad2e510e40dcda06c 375 SUPERFAMILY SSF51412 113 369 3.36E-69 T 17-03-2017 SHXM_RS31580 eac0ae9af020441ad2e510e40dcda06c 375 SMART SM01240 14 370 5.5E-28 T 17-03-2017 SHXM_RS31580 eac0ae9af020441ad2e510e40dcda06c 375 TIGRFAM TIGR01304 IMP_DH_rel_2: IMP dehydrogenase family protein 4 367 2.3E-194 T 17-03-2017 IPR005992 IMP dehydrogenase-related 2 GO:0016491|GO:0055114 SHXM_RS31580 eac0ae9af020441ad2e510e40dcda06c 375 Pfam PF00478 IMP dehydrogenase / GMP reductase domain 15 297 1.1E-42 T 17-03-2017 IPR001093 IMP dehydrogenase/GMP reductase GO:0003824|GO:0055114 SHXM_RS31580 eac0ae9af020441ad2e510e40dcda06c 375 Gene3D G3DSA:3.20.20.70 13 367 4.7E-76 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS17815 e928b1b71089f005047f1dc4a89140ff 254 SMART SM00382 32 225 1.5E-4 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17815 e928b1b71089f005047f1dc4a89140ff 254 Gene3D G3DSA:3.40.50.300 3 236 3.2E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17815 e928b1b71089f005047f1dc4a89140ff 254 SUPERFAMILY SSF52540 4 234 2.2E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17815 e928b1b71089f005047f1dc4a89140ff 254 Pfam PF00005 ABC transporter 23 174 1.6E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17815 e928b1b71089f005047f1dc4a89140ff 254 TIGRFAM TIGR01978 sufC: FeS assembly ATPase SufC 4 245 3.3E-103 T 17-03-2017 IPR010230 FeS cluster assembly SUF system, ATPase SufC GO:0005524|GO:0006810 SHXM_RS05600 a8a08bab0d5a03f1a7a31ce3a01edb80 287 Pfam PF13560 Helix-turn-helix domain 5 84 3.8E-17 T 17-03-2017 SHXM_RS05600 a8a08bab0d5a03f1a7a31ce3a01edb80 287 SUPERFAMILY SSF47413 29 80 9.19E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05600 a8a08bab0d5a03f1a7a31ce3a01edb80 287 Gene3D G3DSA:1.10.260.40 4 80 7.7E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS05600 a8a08bab0d5a03f1a7a31ce3a01edb80 287 SMART SM00530 9 81 1.1E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS09575 756a2b2300ae7ab8739815d9bbeee289 233 SUPERFAMILY SSF81901 40 224 2.88E-19 T 17-03-2017 SHXM_RS09575 756a2b2300ae7ab8739815d9bbeee289 233 Pfam PF12688 Tetratrico peptide repeat 122 152 0.0061 T 17-03-2017 SHXM_RS09575 756a2b2300ae7ab8739815d9bbeee289 233 Gene3D G3DSA:1.25.40.10 41 227 3.8E-24 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25100 6eea87d6a59eb3ffd7da01c32d8d8c21 183 Pfam PF09349 OHCU decarboxylase 21 164 6.3E-18 T 17-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 SHXM_RS25100 6eea87d6a59eb3ffd7da01c32d8d8c21 183 Gene3D G3DSA:1.10.3330.10 25 168 9.8E-28 T 17-03-2017 IPR018020 Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase KEGG: 00230+4.1.1.97|MetaCyc: PWY-5691|MetaCyc: PWY-7394 SHXM_RS25100 6eea87d6a59eb3ffd7da01c32d8d8c21 183 SUPERFAMILY SSF158694 17 167 2.22E-28 T 17-03-2017 SHXM_RS18680 b33a64f7ca44d40762fd6ee34fa17326 121 Pfam PF12728 Helix-turn-helix domain 15 48 1.4E-6 T 17-03-2017 SHXM_RS12435 879912b6b1acb3acdf3a1c32a859a269 154 Hamap MF_00651 Putative pre-16S rRNA nuclease [yqgF]. 4 140 23.088 T 17-03-2017 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 SHXM_RS12435 879912b6b1acb3acdf3a1c32a859a269 154 Pfam PF03652 Holliday junction resolvase 5 137 8.3E-44 T 17-03-2017 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 SHXM_RS12435 879912b6b1acb3acdf3a1c32a859a269 154 Gene3D G3DSA:3.30.420.140 3 144 4.4E-48 T 17-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 SHXM_RS12435 879912b6b1acb3acdf3a1c32a859a269 154 TIGRFAM TIGR00250 RNAse_H_YqgF: putative transcription antitermination factor YqgF 8 137 7.3E-32 T 17-03-2017 IPR005227 Putative pre-16S rRNA nuclease GO:0006364 SHXM_RS12435 879912b6b1acb3acdf3a1c32a859a269 154 SUPERFAMILY SSF53098 4 137 5.92E-36 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS12435 879912b6b1acb3acdf3a1c32a859a269 154 SMART SM00732 4 105 2.5E-33 T 17-03-2017 IPR006641 YqgF/RNase H-like domain GO:0006139 SHXM_RS25370 fd1b6aa04a46134f52b1b0513685fa7e 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 100 111 1.4E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25370 fd1b6aa04a46134f52b1b0513685fa7e 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 147 163 1.4E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25370 fd1b6aa04a46134f52b1b0513685fa7e 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 26 43 1.4E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25370 fd1b6aa04a46134f52b1b0513685fa7e 320 SUPERFAMILY SSF51735 19 274 3.64E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25370 fd1b6aa04a46134f52b1b0513685fa7e 320 Pfam PF00106 short chain dehydrogenase 25 164 1.5E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS25370 fd1b6aa04a46134f52b1b0513685fa7e 320 Gene3D G3DSA:3.40.50.720 23 236 1.3E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42285 993005cb622c1b53471bc6f8e0e37ae2 1083 Pfam PF12905 Endo-alpha-N-acetylgalactosaminidase 336 724 3.8E-168 T 17-03-2017 IPR025706 Endo-alpha-N-acetylgalactosaminidase GO:0033926 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 Gene3D G3DSA:1.10.10.60 221 273 2.2E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 239 254 8.9E-6 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 PRINTS PR00032 AraC bacterial regulatory protein HTH signature 254 270 8.9E-6 T 17-03-2017 IPR020449 Transcription regulator HTH, AraC- type GO:0003700|GO:0006355 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 SMART SM00342 185 270 1.5E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 Gene3D G3DSA:1.10.10.60 164 220 1.3E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 Pfam PF12833 Helix-turn-helix domain 191 271 3.8E-22 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 Pfam PF14525 AraC-binding-like domain 2 150 1.2E-22 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS44270 ee7e99e5db14ced01982369fbf787173 281 SUPERFAMILY SSF46689 221 272 9.41E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22400 799a5e890dc3d164347f74230c23bc0d 320 SUPERFAMILY SSF161098 71 298 1.06E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22400 799a5e890dc3d164347f74230c23bc0d 320 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 83 299 6.5E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22400 799a5e890dc3d164347f74230c23bc0d 320 SUPERFAMILY SSF160964 29 86 2.09E-6 T 17-03-2017 SHXM_RS22400 799a5e890dc3d164347f74230c23bc0d 320 Gene3D G3DSA:1.10.3720.10 22 302 1.7E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08850 a9af7ca00ffa9dd0d916c65c5b7a3539 994 Pfam PF13700 Domain of unknown function (DUF4158) 3 151 1.3E-18 T 17-03-2017 IPR025296 Domain of unknown function DUF4158 SHXM_RS08850 a9af7ca00ffa9dd0d916c65c5b7a3539 994 Pfam PF01526 Tn3 transposase DDE domain 572 960 5.9E-124 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS17940 cc95d75af008e67635bdd34a0ff44073 339 Pfam PF01933 Uncharacterised protein family UPF0052 24 289 6.2E-72 T 17-03-2017 IPR002882 LPPG:FO 2-phospho-L-lactate transferase CofD/UPF0052 SHXM_RS17940 cc95d75af008e67635bdd34a0ff44073 339 Gene3D G3DSA:3.40.50.10680 97 330 3.9E-44 T 17-03-2017 SHXM_RS17940 cc95d75af008e67635bdd34a0ff44073 339 SUPERFAMILY SSF142338 21 325 4.97E-84 T 17-03-2017 SHXM_RS17940 cc95d75af008e67635bdd34a0ff44073 339 Hamap MF_00973 Gluconeogenesis factor. 20 331 32.529 T 17-03-2017 IPR010119 Gluconeogenesis factor SHXM_RS17940 cc95d75af008e67635bdd34a0ff44073 339 TIGRFAM TIGR01826 CofD_related: conserved hypothetical protein 24 290 8.0E-85 T 17-03-2017 IPR010119 Gluconeogenesis factor SHXM_RS45410 8ca90e8159255b33309cf8b571fae895 135 SUPERFAMILY SSF55298 4 134 3.61E-26 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS45410 8ca90e8159255b33309cf8b571fae895 135 Gene3D G3DSA:3.30.1330.40 1 135 5.8E-32 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS45410 8ca90e8159255b33309cf8b571fae895 135 Pfam PF01042 Endoribonuclease L-PSP 17 133 1.7E-17 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS14380 ba92744b04ff1357a12cd1f4d8c1282e 368 SUPERFAMILY SSF81606 158 364 4.45E-9 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14380 ba92744b04ff1357a12cd1f4d8c1282e 368 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 169 365 8.5E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14380 ba92744b04ff1357a12cd1f4d8c1282e 368 SMART SM00331 143 366 1.0E-29 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 ProSitePatterns PS00352 'Cold-shock' domain signature. 15 33 - T 17-03-2017 IPR019844 Cold-shock conserved site SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 PRINTS PR00050 Cold shock protein signature 24 33 1.2E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 PRINTS PR00050 Cold shock protein signature 38 56 1.2E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 PRINTS PR00050 Cold shock protein signature 4 19 1.2E-13 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 Gene3D G3DSA:2.40.50.140 3 64 1.2E-24 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 Pfam PF00313 'Cold-shock' DNA-binding domain 3 64 9.4E-21 T 17-03-2017 IPR002059 Cold-shock protein, DNA-binding GO:0003677|GO:0006355 SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 SUPERFAMILY SSF50249 2 65 1.13E-18 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS25735 2337fefba1c29b4097ec9f41d3adfe11 127 SMART SM00357 3 65 6.8E-21 T 17-03-2017 IPR011129 Cold shock protein GO:0003676 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 Gene3D G3DSA:1.10.540.10 2 121 5.8E-18 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 SUPERFAMILY SSF47203 234 375 2.26E-27 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 120 3.0E-16 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 Gene3D G3DSA:2.40.110.10 131 213 1.8E-11 T 17-03-2017 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 Gene3D G3DSA:1.20.140.10 214 375 2.8E-26 T 17-03-2017 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 SUPERFAMILY SSF56645 2 220 3.4E-35 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS28305 b6552c00d57fff8f023d22b510514486 382 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 365 2.3E-19 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS17045 6afb1d28d8aaafe171cb53af5c0e982f 238 TIGRFAM TIGR00017 cmk: cytidylate kinase 16 229 1.1E-64 T 17-03-2017 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 SHXM_RS17045 6afb1d28d8aaafe171cb53af5c0e982f 238 SUPERFAMILY SSF52540 16 234 6.56E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17045 6afb1d28d8aaafe171cb53af5c0e982f 238 Pfam PF02224 Cytidylate kinase 18 232 9.5E-67 T 17-03-2017 IPR011994 Cytidylate kinase domain GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 SHXM_RS17045 6afb1d28d8aaafe171cb53af5c0e982f 238 Gene3D G3DSA:3.40.50.300 16 232 5.8E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17045 6afb1d28d8aaafe171cb53af5c0e982f 238 Hamap MF_00238 Cytidylate kinase [cmk]. 16 235 31.342 T 17-03-2017 IPR003136 Cytidylate kinase GO:0004127|GO:0005524|GO:0006139 MetaCyc: PWY-7205 SHXM_RS00970 5a391b1e76c06e8e05639dca5082f0b1 172 Gene3D G3DSA:3.40.630.30 10 171 2.2E-40 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS00970 5a391b1e76c06e8e05639dca5082f0b1 172 Pfam PF13420 Acetyltransferase (GNAT) domain 13 164 1.3E-16 T 17-03-2017 SHXM_RS00970 5a391b1e76c06e8e05639dca5082f0b1 172 SUPERFAMILY SSF55729 8 171 2.44E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS10160 c0ede2b5cef1814a36320e494108349b 356 Gene3D G3DSA:2.130.10.80 16 132 1.8E-7 T 17-03-2017 IPR015916 Galactose oxidase, beta-propeller SHXM_RS10160 c0ede2b5cef1814a36320e494108349b 356 Gene3D G3DSA:2.130.10.10 267 354 1.8E-10 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS10160 c0ede2b5cef1814a36320e494108349b 356 Gene3D G3DSA:2.130.10.10 133 211 1.8E-10 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS10160 c0ede2b5cef1814a36320e494108349b 356 SUPERFAMILY SSF50998 182 338 7.85E-17 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS10160 c0ede2b5cef1814a36320e494108349b 356 SUPERFAMILY SSF50998 24 110 7.85E-17 T 17-03-2017 IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily SHXM_RS35445 2778fdae0f87ad009ef1955da112b925 216 Gene3D G3DSA:3.60.160.10 8 211 1.7E-43 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS35445 2778fdae0f87ad009ef1955da112b925 216 Pfam PF01987 Mitochondrial biogenesis AIM24 8 211 9.3E-33 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS35445 2778fdae0f87ad009ef1955da112b925 216 SUPERFAMILY SSF51219 3 213 6.02E-44 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 Gene3D G3DSA:3.40.50.1440 11 211 9.9E-91 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 PRINTS PR00423 Cell division protein FtsZ signature 209 230 1.5E-51 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 PRINTS PR00423 Cell division protein FtsZ signature 95 115 1.5E-51 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 PRINTS PR00423 Cell division protein FtsZ signature 123 144 1.5E-51 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 PRINTS PR00423 Cell division protein FtsZ signature 186 208 1.5E-51 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 ProSitePatterns PS01135 FtsZ protein signature 2. 94 115 - T 17-03-2017 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 SUPERFAMILY SSF52490 9 205 1.28E-66 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 Gene3D G3DSA:3.30.1330.20 212 314 3.2E-49 T 17-03-2017 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Reactome: R-HSA-1445148|Reactome: R-HSA-190840|Reactome: R-HSA-190861|Reactome: R-HSA-2132295|Reactome: R-HSA-2467813|Reactome: R-HSA-2500257|Reactome: R-HSA-380320|Reactome: R-HSA-437239|Reactome: R-HSA-5617833|Reactome: R-HSA-5626467|Reactome: R-HSA-5663220|Reactome: R-HSA-6807878|Reactome: R-HSA-6811434|Reactome: R-HSA-6811436|Reactome: R-HSA-68877|Reactome: R-HSA-8852276|Reactome: R-HSA-983189 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 Hamap MF_00909 Cell division protein FtsZ [ftsZ]. 6 368 38.757 T 17-03-2017 IPR000158 Cell division protein FtsZ GO:0005525 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 ProSitePatterns PS01134 FtsZ protein signature 1. 41 75 - T 17-03-2017 IPR020805 Cell division protein FtsZ, conserved site GO:0005525|GO:0005737 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 Pfam PF00091 Tubulin/FtsZ family, GTPase domain 11 170 5.5E-37 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 TIGRFAM TIGR00065 ftsZ: cell division protein FtsZ 7 314 5.0E-127 T 17-03-2017 IPR000158 Cell division protein FtsZ GO:0005525 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 Pfam PF12327 FtsZ family, C-terminal domain 219 313 4.6E-35 T 17-03-2017 IPR024757 Cell division protein FtsZ, C-terminal SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 SUPERFAMILY SSF55307 201 315 5.49E-44 T 17-03-2017 IPR008280 Tubulin/FtsZ, C-terminal Reactome: R-HSA-380320 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 SMART SM00865 204 321 2.0E-57 T 17-03-2017 IPR018316 Tubulin/FtsZ, 2-layer sandwich domain Reactome: R-HSA-1445148|Reactome: R-HSA-190840|Reactome: R-HSA-190861|Reactome: R-HSA-2132295|Reactome: R-HSA-2467813|Reactome: R-HSA-2500257|Reactome: R-HSA-380320|Reactome: R-HSA-437239|Reactome: R-HSA-5617833|Reactome: R-HSA-5626467|Reactome: R-HSA-5663220|Reactome: R-HSA-6807878|Reactome: R-HSA-6811434|Reactome: R-HSA-6811436|Reactome: R-HSA-68877|Reactome: R-HSA-8852276|Reactome: R-HSA-983189 SHXM_RS18555 5f4b8efd4ad827f2bc03f5681a0d0ddd 411 SMART SM00864 10 202 7.1E-108 T 17-03-2017 IPR003008 Tubulin/FtsZ, GTPase domain GO:0003924 Reactome: R-HSA-380320 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 12 23 2.6E-13 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 23 36 2.6E-13 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 46 66 2.6E-13 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 TIGRFAM TIGR01950 SoxR: redox-sensitive transcriptional activator SoxR 10 149 3.9E-63 T 17-03-2017 IPR010211 Redox-sensitive transcriptional activator SoxR GO:0003677|GO:0006355|GO:0006979|GO:0051537 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 Gene3D G3DSA:1.10.1660.10 10 64 5.1E-22 T 17-03-2017 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 SUPERFAMILY SSF46955 11 121 4.03E-29 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 Pfam PF13411 MerR HTH family regulatory protein 12 77 8.6E-17 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 SMART SM00422 11 79 6.1E-25 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS30040 1bcdc6867e4480a245a2e06230b92e17 153 Gene3D G3DSA:1.10.1660.10 65 144 7.7E-17 T 17-03-2017 SHXM_RS02500 6964f399a44aedd89aca4868f109eeeb 134 SUPERFAMILY SSF54427 26 116 6.19E-7 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS18020 6c348230e50157f9554e221e94d96d72 217 Pfam PF14273 Domain of unknown function (DUF4360) 34 212 9.6E-69 T 17-03-2017 IPR025649 Protein of unknown function DUF4360 SHXM_RS34355 447211724c673a608966641a2693be5d 494 Pfam PF10103 Zinicin-like metallopeptidase 83 435 1.7E-129 T 17-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 SHXM_RS34355 447211724c673a608966641a2693be5d 494 SUPERFAMILY SSF55486 82 435 1.54E-118 T 17-03-2017 SHXM_RS34355 447211724c673a608966641a2693be5d 494 TIGRFAM TIGR03624 TIGR03624: putative hydrolase 83 436 9.6E-126 T 17-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 SUPERFAMILY SSF56655 17 270 1.96E-44 T 17-03-2017 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 Gene3D G3DSA:3.40.190.80 160 271 1.5E-18 T 17-03-2017 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 PRINTS PR00377 Inositol monophosphatase superfamily signature 141 164 6.7E-18 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 PRINTS PR00377 Inositol monophosphatase superfamily signature 92 108 6.7E-18 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 PRINTS PR00377 Inositol monophosphatase superfamily signature 190 211 6.7E-18 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 PRINTS PR00377 Inositol monophosphatase superfamily signature 221 245 6.7E-18 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 Gene3D G3DSA:3.30.540.10 17 159 5.8E-25 T 17-03-2017 SHXM_RS05720 641601ef9d499baa5403ef7e13a4b47e 274 Pfam PF00459 Inositol monophosphatase family 22 265 2.2E-29 T 17-03-2017 IPR000760 Inositol monophosphatase GO:0046854 SHXM_RS41400 2b0e9ab0bc4020bf831d2037e960a112 133 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 10 129 9.7E-31 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS41400 2b0e9ab0bc4020bf831d2037e960a112 133 Gene3D G3DSA:2.30.110.10 7 130 4.2E-30 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41400 2b0e9ab0bc4020bf831d2037e960a112 133 SUPERFAMILY SSF50475 5 130 2.43E-28 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41400 2b0e9ab0bc4020bf831d2037e960a112 133 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 7 89 9.0E-14 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 Pfam PF07690 Major Facilitator Superfamily 38 451 4.6E-36 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 SUPERFAMILY SSF103473 543 568 1.26E-46 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 SUPERFAMILY SSF103473 282 462 1.26E-46 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 SUPERFAMILY SSF103473 24 225 1.26E-46 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 Gene3D G3DSA:1.20.1250.20 542 565 1.3E-14 T 17-03-2017 SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 Gene3D G3DSA:1.20.1250.20 27 219 1.4E-21 T 17-03-2017 SHXM_RS02660 8986025a93ef5fa6d623d50b8af3b2b0 655 Gene3D G3DSA:1.20.1250.20 312 459 1.3E-14 T 17-03-2017 SHXM_RS02355 326d0ca02fc3da6b179067802b619bf9 326 SUPERFAMILY SSF56436 37 323 9.23E-91 T 17-03-2017 IPR016187 C-type lectin fold SHXM_RS02355 326d0ca02fc3da6b179067802b619bf9 326 Gene3D G3DSA:3.90.1580.10 36 324 5.0E-95 T 17-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 SHXM_RS02355 326d0ca02fc3da6b179067802b619bf9 326 Pfam PF03781 Sulfatase-modifying factor enzyme 1 37 320 3.9E-83 T 17-03-2017 IPR005532 Sulfatase-modifying factor enzyme Reactome: R-HSA-1660662|Reactome: R-HSA-1663150 SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 ProSitePatterns PS00196 Type-1 copper (blue) proteins signature. 116 131 - T 17-03-2017 IPR028871 Blue (type 1) copper protein, binding site SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 Gene3D G3DSA:2.60.40.420 21 137 5.5E-11 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 Pfam PF12245 Bacterial Ig-like domain (group 3) 303 321 0.26 T 17-03-2017 IPR022038 Bacterial Ig-like domain SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 Pfam PF12245 Bacterial Ig-like domain (group 3) 401 411 1.2 T 17-03-2017 IPR022038 Bacterial Ig-like domain SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 Pfam PF12245 Bacterial Ig-like domain (group 3) 209 227 0.18 T 17-03-2017 IPR022038 Bacterial Ig-like domain SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 Pfam PF06439 Domain of Unknown Function (DUF1080) 517 723 4.1E-31 T 17-03-2017 IPR010496 Domain of unknown function DUF1080 SHXM_RS07810 8e4753968ed2b8b21d187e9ddd2e828c 725 SUPERFAMILY SSF49503 33 137 2.65E-11 T 17-03-2017 IPR008972 Cupredoxin SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 PRINTS PR00344 Bacterial sensor protein C-terminal signature 367 385 2.0E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 PRINTS PR00344 Bacterial sensor protein C-terminal signature 344 358 2.0E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 PRINTS PR00344 Bacterial sensor protein C-terminal signature 391 404 2.0E-5 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 PIRSF PIRSF037434 6 410 6.7E-134 T 17-03-2017 IPR017205 Signal transduction histidine kinase, ChrS SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 Gene3D G3DSA:3.30.565.10 279 405 2.6E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 SUPERFAMILY SSF55874 279 404 9.69E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 Pfam PF07730 Histidine kinase 204 271 5.6E-18 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS03795 7ce864f830437d34816666527a28fd4d 421 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 313 405 7.0E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39830 49875c39c5bb8b0959f179d8293cddca 242 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 3.2E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39830 49875c39c5bb8b0959f179d8293cddca 242 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 3.2E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39830 49875c39c5bb8b0959f179d8293cddca 242 Gene3D G3DSA:1.10.357.10 3 172 2.4E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS39830 49875c39c5bb8b0959f179d8293cddca 242 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 58 6.0E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39830 49875c39c5bb8b0959f179d8293cddca 242 SUPERFAMILY SSF48498 84 159 1.74E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS39830 49875c39c5bb8b0959f179d8293cddca 242 SUPERFAMILY SSF46689 4 73 9.45E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11770 49b964620a5b4154ed5ca06a99974b31 278 SUPERFAMILY SSF53474 3 272 3.12E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11770 49b964620a5b4154ed5ca06a99974b31 278 Gene3D G3DSA:3.40.50.1820 3 272 3.0E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11770 49b964620a5b4154ed5ca06a99974b31 278 Pfam PF12697 Alpha/beta hydrolase family 23 264 8.7E-20 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11770 49b964620a5b4154ed5ca06a99974b31 278 PRINTS PR00412 Epoxide hydrolase signature 27 45 2.9E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS11770 49b964620a5b4154ed5ca06a99974b31 278 PRINTS PR00412 Epoxide hydrolase signature 47 62 2.9E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS11770 49b964620a5b4154ed5ca06a99974b31 278 PRINTS PR00412 Epoxide hydrolase signature 248 270 2.9E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS19845 1dc970e98a457a18fbf0803be1a3cbb1 598 Pfam PF02361 Cobalt transport protein 74 268 7.9E-8 T 17-03-2017 IPR003339 ABC/ECF transporter, transmembrane component SHXM_RS17985 718f7fa6ca26171115a0bb8d1d55eb6a 436 ProSitePatterns PS00217 Sugar transport proteins signature 2. 115 140 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS17985 718f7fa6ca26171115a0bb8d1d55eb6a 436 SUPERFAMILY SSF103473 3 414 1.57E-59 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS17985 718f7fa6ca26171115a0bb8d1d55eb6a 436 Gene3D G3DSA:1.20.1250.20 28 211 8.4E-25 T 17-03-2017 SHXM_RS17985 718f7fa6ca26171115a0bb8d1d55eb6a 436 Gene3D G3DSA:1.20.1250.20 228 420 2.1E-19 T 17-03-2017 SHXM_RS17985 718f7fa6ca26171115a0bb8d1d55eb6a 436 Pfam PF00083 Sugar (and other) transporter 7 222 1.6E-27 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS17985 718f7fa6ca26171115a0bb8d1d55eb6a 436 Pfam PF07690 Major Facilitator Superfamily 271 424 6.5E-11 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS21200 21ff44725356fe56dc7e89a2918d4e05 750 SUPERFAMILY SSF82866 162 362 5.1E-35 T 17-03-2017 SHXM_RS21200 21ff44725356fe56dc7e89a2918d4e05 750 Pfam PF03176 MMPL family 509 711 4.8E-40 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS21200 21ff44725356fe56dc7e89a2918d4e05 750 Pfam PF03176 MMPL family 70 392 8.1E-70 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS21200 21ff44725356fe56dc7e89a2918d4e05 750 SUPERFAMILY SSF82866 502 701 1.83E-27 T 17-03-2017 SHXM_RS21200 21ff44725356fe56dc7e89a2918d4e05 750 Gene3D G3DSA:1.20.1640.10 157 362 6.8E-35 T 17-03-2017 SHXM_RS21200 21ff44725356fe56dc7e89a2918d4e05 750 Gene3D G3DSA:1.20.1640.10 524 703 2.6E-22 T 17-03-2017 SHXM_RS25955 3bbea84afd1923986c0fe08903d30ae2 212 SMART SM00849 27 191 5.3E-37 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS25955 3bbea84afd1923986c0fe08903d30ae2 212 Pfam PF00753 Metallo-beta-lactamase superfamily 27 191 1.4E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS25955 3bbea84afd1923986c0fe08903d30ae2 212 SUPERFAMILY SSF56281 13 204 4.47E-46 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS25955 3bbea84afd1923986c0fe08903d30ae2 212 Gene3D G3DSA:3.60.15.10 27 198 2.6E-47 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS18170 423854338279ab0571c944b11a1c13d5 238 SMART SM00382 29 216 3.4E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS18170 423854338279ab0571c944b11a1c13d5 238 Gene3D G3DSA:3.40.50.300 4 232 6.2E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18170 423854338279ab0571c944b11a1c13d5 238 SUPERFAMILY SSF52540 4 236 5.54E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18170 423854338279ab0571c944b11a1c13d5 238 PIRSF PIRSF039137 1 238 1.3E-109 T 17-03-2017 IPR030660 High-affinity branched-chain amino acid transport ATP-binding protein GO:0015658|GO:0015803 SHXM_RS18170 423854338279ab0571c944b11a1c13d5 238 Pfam PF00005 ABC transporter 21 165 5.4E-29 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS18170 423854338279ab0571c944b11a1c13d5 238 ProSitePatterns PS00211 ABC transporters family signature. 138 152 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS40440 14f3892d2c0bce107b6e06227f3bb02a 316 Gene3D G3DSA:3.40.630.30 204 304 2.2E-10 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS40440 14f3892d2c0bce107b6e06227f3bb02a 316 SUPERFAMILY SSF55729 24 307 5.7E-22 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS40440 14f3892d2c0bce107b6e06227f3bb02a 316 Pfam PF00583 Acetyltransferase (GNAT) family 235 304 3.5E-6 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00111 Alpha/beta hydrolase fold signature 114 127 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00111 Alpha/beta hydrolase fold signature 51 66 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00111 Alpha/beta hydrolase fold signature 100 113 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 SUPERFAMILY SSF53474 2 291 1.28E-68 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 Gene3D G3DSA:3.40.50.1820 2 291 8.8E-61 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 Pfam PF00561 alpha/beta hydrolase fold 26 248 1.7E-22 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00412 Epoxide hydrolase signature 100 113 1.8E-8 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00412 Epoxide hydrolase signature 114 127 1.8E-8 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00412 Epoxide hydrolase signature 267 289 1.8E-8 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS01605 4a5d3a95c0d1911cd2ae96a60375b201 291 PRINTS PR00412 Epoxide hydrolase signature 32 50 1.8E-8 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS09320 d9f8ecc79a693a3e4d2706ec6784c65c 104 Pfam PF08388 Group II intron, maturase-specific domain 4 77 3.0E-20 T 17-03-2017 IPR013597 Group II intron, maturase-specific SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 PRINTS PR00359 B-class P450 signature 118 129 1.1E-9 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 PRINTS PR00359 B-class P450 signature 354 363 1.1E-9 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 PRINTS PR00359 B-class P450 signature 214 236 1.1E-9 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 PRINTS PR00359 B-class P450 signature 363 374 1.1E-9 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 PRINTS PR00359 B-class P450 signature 164 180 1.1E-9 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 SUPERFAMILY SSF48264 16 416 3.01E-53 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 Gene3D G3DSA:1.10.630.10 16 417 3.1E-78 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24665 04f03964c6ea8b4b9d33a1059bcb9540 510 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 356 365 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS04465 070848dd0dd2f92f0f132775ae5ae4ec 352 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 132 306 4.1E-52 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS04465 070848dd0dd2f92f0f132775ae5ae4ec 352 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 245 261 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS04465 070848dd0dd2f92f0f132775ae5ae4ec 352 Gene3D G3DSA:3.40.50.720 141 307 7.0E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04465 070848dd0dd2f92f0f132775ae5ae4ec 352 SUPERFAMILY SSF51735 127 306 1.23E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04465 070848dd0dd2f92f0f132775ae5ae4ec 352 Gene3D G3DSA:3.40.50.720 52 140 1.9E-4 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04465 070848dd0dd2f92f0f132775ae5ae4ec 352 SUPERFAMILY SSF52283 30 156 2.55E-5 T 17-03-2017 SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 Hamap MF_00227 Ribonuclease P protein component [rnpA]. 2 124 16.282 T 17-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 Pfam PF00825 Ribonuclease P 2 121 1.2E-26 T 17-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 TIGRFAM TIGR00188 rnpA: ribonuclease P protein component 4 101 3.4E-16 T 17-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 SUPERFAMILY SSF54211 2 122 2.02E-23 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 Gene3D G3DSA:3.30.230.10 2 121 2.4E-31 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 ProSitePatterns PS00648 Bacterial ribonuclease P protein component signature. 64 78 - T 17-03-2017 IPR020539 Ribonuclease P, conserved site GO:0004526 SHXM_RS28110 abcc2967cb54a6009749603a3610dbde 127 ProDom PD003629 P RIBONUCLEASE COMPONENT HYDROLASE RNASE C5 RNASEP RNA-BINDING PROCESSING ENDONUCLEASE 49 110 2.0E-5 T 17-03-2017 IPR000100 Ribonuclease P GO:0000049|GO:0004526|GO:0008033 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 SUPERFAMILY SSF53850 41 355 1.91E-63 T 17-03-2017 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 Gene3D G3DSA:3.40.190.10 149 285 1.8E-26 T 17-03-2017 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 Pfam PF13343 Bacterial extracellular solute-binding protein 95 324 9.3E-35 T 17-03-2017 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 163 177 5.7E-5 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 67 88 5.7E-5 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 PRINTS PR00909 Bacterial periplasmic spermidine/putrescine-binding protein signature 263 282 5.7E-5 T 17-03-2017 IPR001188 Bacterial periplasmic spermidine/putrescine-binding protein GO:0015846|GO:0019808|GO:0042597 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 Gene3D G3DSA:3.40.190.10 10 144 6.6E-30 T 17-03-2017 SHXM_RS01660 5bdd5441037c6b5a31416783b13b0ef7 361 Gene3D G3DSA:3.40.190.10 286 350 6.6E-30 T 17-03-2017 SHXM_RS03710 b4a2719dd0740afcda77f8a7aadcdc02 257 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 40 232 2.4E-13 T 17-03-2017 IPR018713 Domain of unknown function DUF2236 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 Pfam PF04545 Sigma-70, region 4 139 187 5.7E-13 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 62 94 - T 17-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 35 189 2.2E-23 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 Gene3D G3DSA:1.10.10.10 129 192 4.6E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 Pfam PF04542 Sigma-70 region 2 39 107 7.0E-16 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 SUPERFAMILY SSF88946 31 123 3.18E-20 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 SUPERFAMILY SSF88659 123 191 8.29E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS26560 d2c654f78872132e6bfe6dd58b5e13e2 197 Gene3D G3DSA:1.10.1740.10 32 128 1.1E-21 T 17-03-2017 SHXM_RS13000 c1cb9ff6da461a9fd3fcde4ba8186dbf 229 Pfam PF14016 Protein of unknown function (DUF4232) 94 188 4.1E-13 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS49265 83a2439bc73fc774954a471e1e8ef94e 93 Pfam PF13560 Helix-turn-helix domain 13 71 2.1E-11 T 17-03-2017 SHXM_RS49265 83a2439bc73fc774954a471e1e8ef94e 93 SMART SM00530 16 71 2.8E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS49265 83a2439bc73fc774954a471e1e8ef94e 93 SUPERFAMILY SSF47413 8 73 2.9E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49265 83a2439bc73fc774954a471e1e8ef94e 93 Gene3D G3DSA:1.10.260.40 9 73 1.5E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS19490 604b313280f47b71e19aab619bf8426b 377 Pfam PF09375 Imelysin 139 369 2.2E-39 T 17-03-2017 SHXM_RS19490 604b313280f47b71e19aab619bf8426b 377 Pfam PF13473 Cupredoxin-like domain 15 116 1.1E-13 T 17-03-2017 IPR028096 EfeO-type cupredoxin-like domain SHXM_RS18935 53473b47553390e1cb2b82f861af9b02 117 SUPERFAMILY SSF89360 13 107 1.77E-27 T 17-03-2017 IPR000361 FeS cluster biogenesis SHXM_RS18935 53473b47553390e1cb2b82f861af9b02 117 TIGRFAM TIGR00049 TIGR00049: iron-sulfur cluster assembly accessory protein 13 117 7.3E-36 T 17-03-2017 IPR016092 FeS cluster insertion protein GO:0005198|GO:0016226|GO:0051536 SHXM_RS18935 53473b47553390e1cb2b82f861af9b02 117 ProSitePatterns PS01152 Hypothetical hesB/yadR/yfhF family signature. 99 116 - T 17-03-2017 IPR017870 FeS cluster insertion, C-terminal, conserved site SHXM_RS18935 53473b47553390e1cb2b82f861af9b02 117 Pfam PF01521 Iron-sulphur cluster biosynthesis 13 114 1.2E-18 T 17-03-2017 IPR000361 FeS cluster biogenesis SHXM_RS18935 53473b47553390e1cb2b82f861af9b02 117 Gene3D G3DSA:2.60.300.12 13 107 3.4E-28 T 17-03-2017 IPR000361 FeS cluster biogenesis SHXM_RS40120 1680c6c50296510d79d838ec301fdcef 155 Pfam PF13610 DDE domain 2 117 8.6E-29 T 17-03-2017 IPR032874 DDE domain SHXM_RS30185 d45d54401744a3292769618802a148f0 412 Gene3D G3DSA:1.10.287.130 187 253 3.1E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 Pfam PF00512 His Kinase A (phospho-acceptor) domain 197 262 1.7E-9 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 SMART SM00387 304 412 5.8E-34 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30185 d45d54401744a3292769618802a148f0 412 SMART SM00304 143 196 3.5E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 PRINTS PR00344 Bacterial sensor protein C-terminal signature 396 409 3.7E-9 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 PRINTS PR00344 Bacterial sensor protein C-terminal signature 356 366 3.7E-9 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 PRINTS PR00344 Bacterial sensor protein C-terminal signature 372 390 3.7E-9 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 PRINTS PR00344 Bacterial sensor protein C-terminal signature 338 352 3.7E-9 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 SUPERFAMILY SSF47384 182 262 1.92E-12 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 Gene3D G3DSA:3.30.565.10 266 411 1.1E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30185 d45d54401744a3292769618802a148f0 412 Pfam PF00672 HAMP domain 124 193 3.6E-15 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 SUPERFAMILY SSF55874 254 410 1.83E-31 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30185 d45d54401744a3292769618802a148f0 412 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 304 411 4.7E-20 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30185 d45d54401744a3292769618802a148f0 412 SUPERFAMILY SSF158472 145 193 1.83E-6 T 17-03-2017 SHXM_RS30185 d45d54401744a3292769618802a148f0 412 SMART SM00388 197 262 4.1E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS05405 cb733acae283a8f5e67a2489905bb9c0 416 Pfam PF07690 Major Facilitator Superfamily 15 356 1.5E-21 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS05405 cb733acae283a8f5e67a2489905bb9c0 416 Gene3D G3DSA:1.20.1250.20 220 400 3.1E-15 T 17-03-2017 SHXM_RS05405 cb733acae283a8f5e67a2489905bb9c0 416 Gene3D G3DSA:1.20.1250.20 9 190 6.6E-7 T 17-03-2017 SHXM_RS05405 cb733acae283a8f5e67a2489905bb9c0 416 SUPERFAMILY SSF103473 5 397 2.09E-38 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS13600 9025c216894f2051e7e38e81904b0b1d 1175 Gene3D G3DSA:1.25.10.10 113 259 1.2E-4 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS13600 9025c216894f2051e7e38e81904b0b1d 1175 Gene3D G3DSA:1.25.10.10 445 562 1.2E-4 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS13600 9025c216894f2051e7e38e81904b0b1d 1175 Gene3D G3DSA:1.25.10.10 598 613 1.2E-4 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS13600 9025c216894f2051e7e38e81904b0b1d 1175 SUPERFAMILY SSF48371 410 491 5.4E-5 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS13600 9025c216894f2051e7e38e81904b0b1d 1175 SUPERFAMILY SSF48371 239 267 5.4E-5 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS16155 999ada799d2cb1e1b4f6c9f9d22ae412 29 Pfam PF09604 F subunit of K+-transporting ATPase (Potass_KdpF) 6 29 3.1E-9 T 17-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 SHXM_RS16155 999ada799d2cb1e1b4f6c9f9d22ae412 29 TIGRFAM TIGR02115 potass_kdpF: K+-transporting ATPase, F subunit 7 29 3.7E-10 T 17-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 Pfam PF04542 Sigma-70 region 2 98 161 1.2E-11 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 Pfam PF08281 Sigma-70, region 4 188 239 1.4E-14 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 SUPERFAMILY SSF88946 88 173 1.14E-14 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 SUPERFAMILY SSF88659 180 241 1.48E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 87 244 1.1E-61 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 Gene3D G3DSA:1.10.1740.10 87 161 2.5E-17 T 17-03-2017 SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 Gene3D G3DSA:1.10.10.10 182 241 6.3E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24785 79777b626e937bb1a62cb5498e9295b3 260 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 97 241 6.3E-24 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 SUPERFAMILY SSF48557 10 456 2.04E-80 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 Pfam PF10397 Adenylosuccinate lyase C-terminus 370 452 1.6E-11 T 17-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 SMART SM00998 369 455 3.0E-19 T 17-03-2017 IPR019468 Adenylosuccinate lyase C-terminal KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 Gene3D G3DSA:1.20.200.10 102 451 6.4E-83 T 17-03-2017 SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 Pfam PF00206 Lyase 53 301 1.9E-20 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 PRINTS PR00149 Fumarate lyase superfamily signature 98 116 6.2E-11 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 PRINTS PR00149 Fumarate lyase superfamily signature 143 161 6.2E-11 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 PRINTS PR00149 Fumarate lyase superfamily signature 237 264 6.2E-11 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 PRINTS PR00149 Fumarate lyase superfamily signature 280 296 6.2E-11 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 TIGRFAM TIGR00928 purB: adenylosuccinate lyase 11 454 1.8E-126 T 17-03-2017 IPR004769 Adenylosuccinate lyase GO:0004018|GO:0009152 KEGG: 00230+4.3.2.2|KEGG: 00250+4.3.2.2|MetaCyc: PWY-6123|MetaCyc: PWY-6124|MetaCyc: PWY-7219|MetaCyc: PWY-7234|Reactome: R-HSA-73817 SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 Gene3D G3DSA:1.10.275.10 13 101 6.9E-23 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS08595 f0b5ff12adaca9b8241ebb31337d5a21 477 ProSitePatterns PS00163 Fumarate lyases signature. 280 289 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS26205 9a5b619c5d0b3d967c938fe8ce677521 345 SUPERFAMILY SSF161098 76 280 1.57E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26205 9a5b619c5d0b3d967c938fe8ce677521 345 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 76 139 3.8E-15 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS26205 9a5b619c5d0b3d967c938fe8ce677521 345 Gene3D G3DSA:1.10.3720.10 75 294 2.2E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26205 9a5b619c5d0b3d967c938fe8ce677521 345 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 95 292 3.2E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06485 ff1b30e467db4d72d6adbd8fdcdbeb16 283 TIGRFAM TIGR00027 mthyl_TIGR00027: methyltransferase, TIGR00027 family 9 261 4.6E-56 T 17-03-2017 IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative GO:0008168 SHXM_RS06485 ff1b30e467db4d72d6adbd8fdcdbeb16 283 SUPERFAMILY SSF53335 6 262 9.14E-55 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06485 ff1b30e467db4d72d6adbd8fdcdbeb16 283 Gene3D G3DSA:3.40.50.150 58 187 6.4E-12 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06485 ff1b30e467db4d72d6adbd8fdcdbeb16 283 Pfam PF04072 Leucine carboxyl methyltransferase 12 185 1.3E-46 T 17-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 Gene3D G3DSA:1.10.10.10 6 77 2.4E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 SMART SM00345 15 74 2.4E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 48 64 4.3E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 34 48 4.3E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 SUPERFAMILY SSF48008 91 229 1.18E-25 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 Gene3D G3DSA:1.20.120.530 90 232 3.6E-26 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 SMART SM00895 94 224 1.2E-21 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 Pfam PF00392 Bacterial regulatory proteins, gntR family 12 74 4.2E-20 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 SUPERFAMILY SSF46785 6 78 5.39E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27715 94ceede960e83348e962b78acb77d1fd 236 Pfam PF07729 FCD domain 94 223 2.0E-22 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS01740 c278b029a3ef462f1e7b2d230e4ac4c0 475 Pfam PF01566 Natural resistance-associated macrophage protein 59 364 5.1E-15 T 17-03-2017 IPR001046 NRAMP family GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-425410 SHXM_RS50810 a078271315c06de187906e20bab166e2 107 SUPERFAMILY SSF55811 1 102 1.27E-20 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS50810 a078271315c06de187906e20bab166e2 107 Pfam PF00293 NUDIX domain 2 84 6.3E-10 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS50810 a078271315c06de187906e20bab166e2 107 Gene3D G3DSA:3.90.79.10 1 102 9.5E-20 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS13785 f963a1d68c9cbcf6d29213d8a74efa65 75 Gene3D G3DSA:3.40.50.1820 4 64 5.0E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13785 f963a1d68c9cbcf6d29213d8a74efa65 75 SUPERFAMILY SSF53474 5 64 4.86E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23885 07ffc29c2093a24d2b5ae1650000d878 452 Gene3D G3DSA:3.40.190.10 62 183 1.1E-22 T 17-03-2017 SHXM_RS23885 07ffc29c2093a24d2b5ae1650000d878 452 SUPERFAMILY SSF53850 53 451 3.92E-52 T 17-03-2017 SHXM_RS23885 07ffc29c2093a24d2b5ae1650000d878 452 Gene3D G3DSA:3.40.190.10 184 377 6.6E-27 T 17-03-2017 SHXM_RS23885 07ffc29c2093a24d2b5ae1650000d878 452 Pfam PF01547 Bacterial extracellular solute-binding protein 65 360 4.8E-22 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS20140 f679ae1e9d8655c4ef75c242181d1fdb 393 SUPERFAMILY SSF55874 272 383 1.17E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20140 f679ae1e9d8655c4ef75c242181d1fdb 393 Pfam PF07730 Histidine kinase 186 250 1.3E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS05840 5f07c05a538c4926341d8f1df4c65e0c 780 SUPERFAMILY SSF52540 521 736 7.27E-38 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS05840 5f07c05a538c4926341d8f1df4c65e0c 780 Gene3D G3DSA:3.40.50.300 521 709 1.9E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS05840 5f07c05a538c4926341d8f1df4c65e0c 780 SMART SM00382 565 697 9.4E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS05840 5f07c05a538c4926341d8f1df4c65e0c 780 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 570 693 1.6E-23 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 Pfam PF13377 Periplasmic binding protein-like domain 171 335 4.2E-36 T 17-03-2017 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 SUPERFAMILY SSF53822 63 337 2.17E-68 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 Gene3D G3DSA:1.10.260.40 4 59 1.8E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 SMART SM00354 3 73 3.5E-24 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 Gene3D G3DSA:3.40.50.2300 60 171 9.9E-33 T 17-03-2017 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 2.7E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 SUPERFAMILY SSF47413 2 61 1.19E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS48540 7f77c5761cbea50c0324107d1c567989 345 Gene3D G3DSA:3.40.50.2300 172 336 1.5E-49 T 17-03-2017 SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 SUPERFAMILY SSF46689 226 272 1.03E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 Pfam PF01965 DJ-1/PfpI family 11 182 3.8E-13 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 Gene3D G3DSA:1.10.10.60 276 323 8.0E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 Pfam PF12833 Helix-turn-helix domain 244 322 1.1E-23 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 Gene3D G3DSA:3.40.50.880 11 218 4.8E-44 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 SUPERFAMILY SSF46689 274 325 1.08E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 SUPERFAMILY SSF52317 10 204 9.16E-40 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 Gene3D G3DSA:1.10.10.60 226 275 5.2E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08300 79cafeb998c95200ce424760bd7e8210 331 SMART SM00342 238 321 8.5E-28 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS07250 02dcd0eb31d6be83368bbf7b8c29881f 290 SUPERFAMILY SSF53448 1 285 8.34E-83 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS07250 02dcd0eb31d6be83368bbf7b8c29881f 290 Gene3D G3DSA:3.90.550.10 1 263 6.0E-63 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS07250 02dcd0eb31d6be83368bbf7b8c29881f 290 TIGRFAM TIGR01207 rmlA: glucose-1-phosphate thymidylyltransferase 2 286 5.2E-132 T 17-03-2017 IPR005907 Glucose-1-phosphate thymidylyltransferase, short form GO:0008879|GO:0045226 KEGG: 00521+2.7.7.24|KEGG: 00523+2.7.7.24|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SHXM_RS07250 02dcd0eb31d6be83368bbf7b8c29881f 290 Pfam PF00483 Nucleotidyl transferase 2 235 1.5E-60 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS19205 3d30af54a0c9c8cc4966a7dfe2f46ae5 425 SUPERFAMILY SSF55874 308 415 4.06E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19205 3d30af54a0c9c8cc4966a7dfe2f46ae5 425 Pfam PF07730 Histidine kinase 228 295 2.0E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS19205 3d30af54a0c9c8cc4966a7dfe2f46ae5 425 Gene3D G3DSA:3.30.565.10 330 416 6.4E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS19205 3d30af54a0c9c8cc4966a7dfe2f46ae5 425 Pfam PF13796 Putative sensor 17 199 3.4E-17 T 17-03-2017 IPR025828 Putative sensor domain SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 SUPERFAMILY SSF51905 446 490 2.85E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 SUPERFAMILY SSF51905 35 352 2.85E-39 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 Gene3D G3DSA:3.50.50.60 187 203 1.1E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 Gene3D G3DSA:3.50.50.60 245 325 1.1E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 Gene3D G3DSA:3.50.50.60 37 116 1.1E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 Gene3D G3DSA:3.50.50.60 434 487 1.1E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 Pfam PF01593 Flavin containing amine oxidoreductase 44 487 1.4E-32 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 PRINTS PR00419 Adrenodoxin reductase family signature 36 58 1.4E-5 T 17-03-2017 SHXM_RS01445 40e15a4a8254fdb8a5b41912516deea8 518 PRINTS PR00419 Adrenodoxin reductase family signature 59 72 1.4E-5 T 17-03-2017 SHXM_RS13720 b88dc9a6a4f4088f4d3f64d269284f09 549 Gene3D G3DSA:3.40.190.10 215 311 2.2E-18 T 17-03-2017 SHXM_RS13720 b88dc9a6a4f4088f4d3f64d269284f09 549 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 97 468 1.2E-60 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS13720 b88dc9a6a4f4088f4d3f64d269284f09 549 SUPERFAMILY SSF53850 52 544 7.96E-94 T 17-03-2017 SHXM_RS13720 b88dc9a6a4f4088f4d3f64d269284f09 549 Gene3D G3DSA:3.90.76.10 62 214 7.9E-31 T 17-03-2017 SHXM_RS13720 b88dc9a6a4f4088f4d3f64d269284f09 549 Gene3D G3DSA:3.10.105.10 312 515 6.2E-40 T 17-03-2017 SHXM_RS13720 b88dc9a6a4f4088f4d3f64d269284f09 549 PIRSF PIRSF002741 6 545 2.6E-74 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS10795 bff4fb0aee2883c226616e1822ebdd90 475 Pfam PF02447 GntP family permease 8 473 4.4E-116 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS10795 bff4fb0aee2883c226616e1822ebdd90 475 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 10 474 6.0E-113 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS10795 bff4fb0aee2883c226616e1822ebdd90 475 PIRSF PIRSF002746 3 475 2.8E-134 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 Pfam PF00072 Response regulator receiver domain 5 119 7.8E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 SMART SM00421 155 212 6.9E-24 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 Gene3D G3DSA:3.40.50.2300 3 125 1.1E-34 T 17-03-2017 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 Gene3D G3DSA:1.10.10.10 126 218 1.5E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 SMART SM00448 3 118 2.2E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 172 188 1.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 158 172 1.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 188 200 1.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 SUPERFAMILY SSF46894 141 218 9.86E-23 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 SUPERFAMILY SSF52172 3 129 1.99E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 Pfam PF00196 Bacterial regulatory proteins, luxR family 157 212 5.8E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16665 e428174450e219de8a3a1fe524def2c2 231 ProSitePatterns PS00622 LuxR-type HTH domain signature. 172 199 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS34695 36f1fdc92ec29821dafd39218bdf805b 99 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 1 93 2.3E-18 T 17-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 SHXM_RS34695 36f1fdc92ec29821dafd39218bdf805b 99 Gene3D G3DSA:3.30.750.24 1 97 1.0E-20 T 17-03-2017 IPR002645 STAS domain SHXM_RS34695 36f1fdc92ec29821dafd39218bdf805b 99 Pfam PF13466 STAS domain 2 77 1.1E-11 T 17-03-2017 IPR002645 STAS domain SHXM_RS34695 36f1fdc92ec29821dafd39218bdf805b 99 SUPERFAMILY SSF52091 1 96 4.12E-18 T 17-03-2017 IPR002645 STAS domain SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 SUPERFAMILY SSF46894 148 219 2.55E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 SUPERFAMILY SSF52172 9 132 1.22E-27 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 Gene3D G3DSA:1.10.10.10 160 218 1.2E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 SMART SM00421 157 214 1.8E-22 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 SMART SM00448 8 121 6.5E-22 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 Pfam PF00196 Bacterial regulatory proteins, luxR family 158 213 3.1E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 Pfam PF00072 Response regulator receiver domain 10 121 3.5E-21 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 Gene3D G3DSA:3.40.50.2300 8 159 8.5E-33 T 17-03-2017 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 ProSitePatterns PS00622 LuxR-type HTH domain signature. 174 201 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 190 202 1.0E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 160 174 1.0E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS26635 87e75e4cc88db5d3783cb082ca0dfe5a 229 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 174 190 1.0E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS32935 0bd6b49a82dbe2d296eb551473edd744 103 PIRSF PIRSF028743 1 103 2.3E-34 T 17-03-2017 IPR008634 Gas vesicle protein GvpO GO:0031412 SHXM_RS32935 0bd6b49a82dbe2d296eb551473edd744 103 Pfam PF05800 Gas vesicle synthesis protein GvpO 12 101 3.2E-35 T 17-03-2017 IPR008634 Gas vesicle protein GvpO GO:0031412 SHXM_RS06125 dd3413b15c5a36004fad9e3516e123f0 507 Pfam PF00795 Carbon-nitrogen hydrolase 204 436 4.3E-22 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS06125 dd3413b15c5a36004fad9e3516e123f0 507 Gene3D G3DSA:3.60.110.10 196 447 1.6E-35 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS06125 dd3413b15c5a36004fad9e3516e123f0 507 Hamap MF_01148 Apolipoprotein N-acyltransferase [lnt]. 1 464 15.395 T 17-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 SHXM_RS06125 dd3413b15c5a36004fad9e3516e123f0 507 TIGRFAM TIGR00546 lnt: apolipoprotein N-acyltransferase 50 425 1.7E-88 T 17-03-2017 IPR004563 Apolipoprotein N-acyltransferase GO:0016021|GO:0016410|GO:0042158 SHXM_RS06125 dd3413b15c5a36004fad9e3516e123f0 507 SUPERFAMILY SSF56317 198 459 1.26E-42 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS02190 4a9dd815e6e1bd3c960609e652e1a3ce 72 Gene3D G3DSA:3.90.820.10 11 69 4.3E-32 T 17-03-2017 SHXM_RS02190 4a9dd815e6e1bd3c960609e652e1a3ce 72 Pfam PF03621 MbtH-like protein 1 53 7.4E-30 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS02190 4a9dd815e6e1bd3c960609e652e1a3ce 72 SUPERFAMILY SSF160582 1 68 9.94E-33 T 17-03-2017 SHXM_RS02190 4a9dd815e6e1bd3c960609e652e1a3ce 72 SMART SM00923 3 53 7.8E-33 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS13845 91b2b301f8beaba6114e81dd8eb892cb 127 SUPERFAMILY SSF53067 35 108 1.79E-11 T 17-03-2017 SHXM_RS13845 91b2b301f8beaba6114e81dd8eb892cb 127 Pfam PF00480 ROK family 35 108 1.2E-8 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS13845 91b2b301f8beaba6114e81dd8eb892cb 127 Gene3D G3DSA:3.30.420.40 37 107 5.3E-10 T 17-03-2017 SHXM_RS29810 cc2d1e0230c88b1a05192188820f5521 691 Pfam PF00733 Asparagine synthase 256 660 1.8E-8 T 17-03-2017 IPR001962 Asparagine synthase GO:0004066|GO:0006529 SHXM_RS29810 cc2d1e0230c88b1a05192188820f5521 691 SUPERFAMILY SSF56235 57 186 2.47E-11 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS29810 cc2d1e0230c88b1a05192188820f5521 691 Gene3D G3DSA:3.60.20.10 61 180 1.4E-8 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS29810 cc2d1e0230c88b1a05192188820f5521 691 Gene3D G3DSA:3.40.50.620 541 660 3.0E-4 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS29810 cc2d1e0230c88b1a05192188820f5521 691 SUPERFAMILY SSF52402 252 395 1.93E-7 T 17-03-2017 SHXM_RS29810 cc2d1e0230c88b1a05192188820f5521 691 SUPERFAMILY SSF52402 519 584 1.93E-7 T 17-03-2017 SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 Hamap MF_03210 Formate dehydrogenase, mitochondrial. 2 383 56.258 T 17-03-2017 IPR033689 NAD-dependent formate dehydrogenase GO:0008863 KEGG: 00630+1.2.1.2|KEGG: 00680+1.2.1.2|MetaCyc: PWY-1881|MetaCyc: PWY-5497|MetaCyc: PWY-6696 SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 156 335 1.4E-45 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 ProSitePatterns PS00670 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. 245 267 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 Gene3D G3DSA:3.40.50.720 186 343 3.3E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 Pfam PF00389 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 62 361 6.8E-17 T 17-03-2017 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0008152|GO:0016616|GO:0051287|GO:0055114 SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 SUPERFAMILY SSF51735 150 336 1.13E-50 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 ProSitePatterns PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 195 222 - T 17-03-2017 IPR029752 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1 SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 Gene3D G3DSA:3.40.50.720 2 185 1.8E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40500 48873476b92667fe477d77ca18993a3b 386 SUPERFAMILY SSF52283 3 176 6.17E-64 T 17-03-2017 SHXM_RS31800 03fb5fa1fb5f2a00c9c3ace19512a67d 189 SUPERFAMILY SSF50249 49 180 4.11E-30 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31800 03fb5fa1fb5f2a00c9c3ace19512a67d 189 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 64 95 2.1E-11 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS31800 03fb5fa1fb5f2a00c9c3ace19512a67d 189 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 98 173 3.2E-17 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS08270 3816729248066dc8e0c45dbc374fb95c 327 Pfam PF07859 alpha/beta hydrolase fold 85 293 8.6E-69 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS08270 3816729248066dc8e0c45dbc374fb95c 327 Gene3D G3DSA:3.40.50.1820 8 320 1.2E-90 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS08270 3816729248066dc8e0c45dbc374fb95c 327 SUPERFAMILY SSF53474 22 320 4.65E-70 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 SMART SM00116 285 333 2.8 T 17-03-2017 IPR000644 CBS domain SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 SMART SM00116 225 273 2.4 T 17-03-2017 IPR000644 CBS domain SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 Pfam PF00571 CBS domain 284 333 2.4E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 Pfam PF00571 CBS domain 226 271 0.0015 T 17-03-2017 IPR000644 CBS domain SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 Pfam PF01595 Domain of unknown function DUF21 8 200 1.4E-41 T 17-03-2017 IPR002550 Domain of unknown function DUF21 SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 SUPERFAMILY SSF54631 205 335 1.04E-20 T 17-03-2017 SHXM_RS12125 4ac99dd96da7a6efa7be256bc2c6c7c4 370 Gene3D G3DSA:3.10.580.10 226 332 6.0E-13 T 17-03-2017 SHXM_RS07045 e4ae8649bda3bd023ddef5ef0064bb31 381 SUPERFAMILY SSF81606 160 369 1.99E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS07045 e4ae8649bda3bd023ddef5ef0064bb31 381 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 172 371 2.0E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS07045 e4ae8649bda3bd023ddef5ef0064bb31 381 SMART SM00331 144 371 1.1E-34 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS33660 bee1f20fddd3c7c87541721b5f801c2d 102 TIGRFAM TIGR01280 xseB: exodeoxyribonuclease VII, small subunit 24 78 1.7E-20 T 17-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS33660 bee1f20fddd3c7c87541721b5f801c2d 102 SUPERFAMILY SSF116842 19 81 2.48E-16 T 17-03-2017 SHXM_RS33660 bee1f20fddd3c7c87541721b5f801c2d 102 Pfam PF02609 Exonuclease VII small subunit 24 73 9.3E-18 T 17-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS33660 bee1f20fddd3c7c87541721b5f801c2d 102 Hamap MF_00337 Exodeoxyribonuclease 7 small subunit [xseB]. 23 83 14.112 T 17-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS33660 bee1f20fddd3c7c87541721b5f801c2d 102 Gene3D G3DSA:1.10.287.1040 20 83 1.2E-22 T 17-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS33660 bee1f20fddd3c7c87541721b5f801c2d 102 ProDom PD028235 EXONUCLEASE SMALL SUBUNIT VII EXODEOXYRIBONUCLEASE HYDROLASE NUCLEASE PROBABLE VII SIMILAR 22 62 9.0E-15 T 17-03-2017 IPR003761 Exonuclease VII, small subunit GO:0006308|GO:0008855|GO:0009318 SHXM_RS01000 e39279722f706a262957a45830b02940 263 SUPERFAMILY SSF55781 72 251 1.63E-43 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01000 e39279722f706a262957a45830b02940 263 SMART SM00346 10 95 8.2E-20 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS01000 e39279722f706a262957a45830b02940 263 Pfam PF09339 IclR helix-turn-helix domain 11 56 9.2E-11 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS01000 e39279722f706a262957a45830b02940 263 SUPERFAMILY SSF46785 11 79 1.09E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01000 e39279722f706a262957a45830b02940 263 Pfam PF01614 Bacterial transcriptional regulator 125 248 6.3E-24 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS01000 e39279722f706a262957a45830b02940 263 Gene3D G3DSA:3.30.450.40 76 252 4.5E-48 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS01000 e39279722f706a262957a45830b02940 263 Gene3D G3DSA:1.10.10.10 9 75 2.8E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34770 404eb546f32388425261af113e39358b 410 Pfam PF03949 Malic enzyme, NAD binding domain 185 384 1.2E-19 T 17-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 SHXM_RS34770 404eb546f32388425261af113e39358b 410 SMART SM01274 38 171 8.0E-79 T 17-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SHXM_RS34770 404eb546f32388425261af113e39358b 410 Pfam PF00390 Malic enzyme, N-terminal domain 40 171 1.4E-28 T 17-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SHXM_RS34770 404eb546f32388425261af113e39358b 410 Gene3D G3DSA:3.40.50.10380 36 180 6.0E-54 T 17-03-2017 IPR012301 Malic enzyme, N-terminal domain GO:0004471|GO:0055114 SHXM_RS34770 404eb546f32388425261af113e39358b 410 PIRSF PIRSF000106 41 410 9.9E-74 T 17-03-2017 IPR001891 Malic oxidoreductase GO:0004470|GO:0004471|GO:0006108|GO:0055114 SHXM_RS34770 404eb546f32388425261af113e39358b 410 SUPERFAMILY SSF53223 33 181 5.61E-56 T 17-03-2017 SHXM_RS34770 404eb546f32388425261af113e39358b 410 SMART SM00919 183 403 1.0E-104 T 17-03-2017 IPR012302 Malic enzyme, NAD-binding GO:0004471|GO:0051287|GO:0055114 SHXM_RS34770 404eb546f32388425261af113e39358b 410 SUPERFAMILY SSF51735 183 409 2.49E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34770 404eb546f32388425261af113e39358b 410 Gene3D G3DSA:3.40.50.720 181 409 6.5E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45685 4464884283ecb4faaa77a550a3d9027b 411 Gene3D G3DSA:3.30.420.40 229 372 6.9E-33 T 17-03-2017 SHXM_RS45685 4464884283ecb4faaa77a550a3d9027b 411 Gene3D G3DSA:1.10.10.10 22 82 9.0E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45685 4464884283ecb4faaa77a550a3d9027b 411 SUPERFAMILY SSF46785 22 80 1.32E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45685 4464884283ecb4faaa77a550a3d9027b 411 SUPERFAMILY SSF53067 87 391 8.64E-43 T 17-03-2017 SHXM_RS45685 4464884283ecb4faaa77a550a3d9027b 411 Pfam PF00480 ROK family 90 391 1.2E-43 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS45685 4464884283ecb4faaa77a550a3d9027b 411 Gene3D G3DSA:3.30.420.40 83 228 4.0E-39 T 17-03-2017 SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 Pfam PF07729 FCD domain 106 207 2.7E-12 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 SUPERFAMILY SSF46785 8 80 7.39E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 SUPERFAMILY SSF48008 82 219 2.12E-16 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 Pfam PF00392 Bacterial regulatory proteins, gntR family 15 76 2.8E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 Gene3D G3DSA:1.10.10.10 6 77 1.1E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 Gene3D G3DSA:1.20.120.530 80 225 3.7E-17 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 SMART SM00345 18 76 6.9E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS29325 d663053b3fac15aac32f8a2b058683b5 239 SMART SM00895 86 213 0.0019 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS20825 b04b99be4e3d58e24b590e1f88ceb04f 274 Gene3D G3DSA:3.40.1080.10 158 268 6.2E-80 T 17-03-2017 SHXM_RS20825 b04b99be4e3d58e24b590e1f88ceb04f 274 Gene3D G3DSA:3.40.1080.10 5 120 6.2E-80 T 17-03-2017 SHXM_RS20825 b04b99be4e3d58e24b590e1f88ceb04f 274 SUPERFAMILY SSF100950 5 269 5.58E-76 T 17-03-2017 SHXM_RS20825 b04b99be4e3d58e24b590e1f88ceb04f 274 SMART SM00882 4 224 5.2E-43 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS20825 b04b99be4e3d58e24b590e1f88ceb04f 274 Pfam PF01144 Coenzyme A transferase 6 222 9.4E-26 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SUPERFAMILY SSF46955 3 104 2.53E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 Pfam PF13411 MerR HTH family regulatory protein 3 68 5.7E-14 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SUPERFAMILY SSF48371 101 325 8.64E-16 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 Gene3D G3DSA:2.60.120.10 379 478 1.4E-15 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 Gene3D G3DSA:1.10.1660.10 3 88 9.4E-25 T 17-03-2017 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 Gene3D G3DSA:1.25.10.10 89 326 8.7E-18 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 Pfam PF07883 Cupin domain 393 450 8.4E-11 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SUPERFAMILY SSF51182 386 465 4.63E-13 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SMART SM00422 1 70 2.5E-21 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 5.0E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 5.0E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 37 57 5.0E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SMART SM00567 E-Z type HEAT repeats 189 219 2.6 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SMART SM00567 E-Z type HEAT repeats 288 317 190.0 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SMART SM00567 E-Z type HEAT repeats 254 280 140.0 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 SMART SM00567 E-Z type HEAT repeats 221 250 780.0 T 17-03-2017 IPR004155 PBS lyase HEAT-like repeat Reactome: R-HSA-204626 SHXM_RS41080 23e3296de8155bce3b6538063e4ddf80 493 Pfam PF13646 HEAT repeats 180 254 7.3E-10 T 17-03-2017 SHXM_RS43355 a3778cf2cebb9f555b8616b358d03d97 159 Gene3D G3DSA:3.90.79.10 7 147 5.2E-31 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS43355 a3778cf2cebb9f555b8616b358d03d97 159 Pfam PF00293 NUDIX domain 21 135 1.4E-21 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS43355 a3778cf2cebb9f555b8616b358d03d97 159 SUPERFAMILY SSF55811 10 136 1.9E-33 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS16855 cf8a3aeec9f83a42356cabf38cb7af88 170 Pfam PF01047 MarR family 56 114 3.4E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS16855 cf8a3aeec9f83a42356cabf38cb7af88 170 Gene3D G3DSA:1.10.10.10 23 162 1.0E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16855 cf8a3aeec9f83a42356cabf38cb7af88 170 SMART SM00347 49 147 2.7E-19 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS16855 cf8a3aeec9f83a42356cabf38cb7af88 170 SUPERFAMILY SSF46785 17 162 2.34E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 SMART SM00220 9 257 5.1E-38 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 Gene3D G3DSA:3.30.200.20 3 100 1.3E-16 T 17-03-2017 SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 Gene3D G3DSA:1.10.510.10 101 257 4.2E-37 T 17-03-2017 SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 Pfam PF00069 Protein kinase domain 9 247 2.9E-36 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 123 135 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 SUPERFAMILY SSF56112 425 498 1.6E-62 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS28180 f59aad3d9ad27ce6abfa555e8f571405 572 SUPERFAMILY SSF56112 5 262 1.6E-62 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 PRINTS PR00981 Seryl-tRNA synthetase signature 275 288 5.7E-30 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 PRINTS PR00981 Seryl-tRNA synthetase signature 263 275 5.7E-30 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 PRINTS PR00981 Seryl-tRNA synthetase signature 315 328 5.7E-30 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 PRINTS PR00981 Seryl-tRNA synthetase signature 350 366 5.7E-30 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 PRINTS PR00981 Seryl-tRNA synthetase signature 332 348 5.7E-30 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 Hamap MF_00176 Serine--tRNA ligase [serS]. 1 419 38.736 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 SUPERFAMILY SSF46589 2 111 1.88E-23 T 17-03-2017 IPR010978 tRNA-binding arm GO:0000166 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 Pfam PF00587 tRNA synthetase class II core domain (G, H, P, S and T) 222 397 2.8E-28 T 17-03-2017 IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) GO:0000166|GO:0004812|GO:0005524|GO:0006418 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 Gene3D G3DSA:3.30.930.10 104 418 3.1E-124 T 17-03-2017 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 Pfam PF02403 Seryl-tRNA synthetase N-terminal domain 1 106 3.1E-23 T 17-03-2017 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 TIGRFAM TIGR00414 serS: serine--tRNA ligase 2 414 1.4E-132 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 SUPERFAMILY SSF55681 122 416 1.09E-84 T 17-03-2017 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 PIRSF PIRSF001529 1 422 1.8E-139 T 17-03-2017 IPR002317 Serine-tRNA ligase, type1 GO:0000166|GO:0004828|GO:0005524|GO:0005737|GO:0006434 KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS27685 84a0dc61c8d55a1fac25dff225f8ca0d 425 Gene3D G3DSA:1.10.287.40 2 102 2.9E-27 T 17-03-2017 IPR015866 Serine-tRNA synthetase, type1, N-terminal KEGG: 00970+6.1.1.11|MetaCyc: PWY-6281 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 SUPERFAMILY SSF88659 297 389 6.11E-18 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 SUPERFAMILY SSF88946 151 231 4.55E-26 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 PRINTS PR00046 Major sigma-70 factor signature 212 220 5.0E-21 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 PRINTS PR00046 Major sigma-70 factor signature 374 385 5.0E-21 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 PRINTS PR00046 Major sigma-70 factor signature 338 350 5.0E-21 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 PRINTS PR00046 Major sigma-70 factor signature 188 201 5.0E-21 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 PRINTS PR00046 Major sigma-70 factor signature 359 374 5.0E-21 T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 159 386 4.3E-26 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 ProSitePatterns PS00715 Sigma-70 factors family signature 1. 188 201 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 ProSitePatterns PS00716 Sigma-70 factors family signature 2. 359 385 - T 17-03-2017 IPR000943 RNA polymerase sigma-70 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 SUPERFAMILY SSF47413 464 523 7.11E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 Gene3D G3DSA:1.10.260.40 462 515 1.9E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 Pfam PF04542 Sigma-70 region 2 164 231 5.1E-13 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 Gene3D G3DSA:1.10.601.10 116 230 2.3E-28 T 17-03-2017 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 Pfam PF04545 Sigma-70, region 4 337 386 8.5E-16 T 17-03-2017 IPR007630 RNA polymerase sigma-70 region 4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 Gene3D G3DSA:1.10.10.10 237 285 3.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29745 96a041af6d0347856bc426433d6df9b9 1168 Gene3D G3DSA:1.10.10.10 337 386 1.3E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24630 389da587a8e93909b4506d8269d94ccc 260 Gene3D G3DSA:3.10.180.10 143 258 1.1E-32 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS24630 389da587a8e93909b4506d8269d94ccc 260 Gene3D G3DSA:3.10.180.10 11 128 3.3E-34 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS24630 389da587a8e93909b4506d8269d94ccc 260 SUPERFAMILY SSF54593 141 258 7.65E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS24630 389da587a8e93909b4506d8269d94ccc 260 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 148 251 3.7E-5 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS24630 389da587a8e93909b4506d8269d94ccc 260 SUPERFAMILY SSF54593 12 128 4.95E-18 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 SUPERFAMILY SSF53850 15 260 7.26E-63 T 17-03-2017 SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 Gene3D G3DSA:3.40.190.10 121 221 1.2E-25 T 17-03-2017 SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 Gene3D G3DSA:3.40.190.10 222 260 3.4E-35 T 17-03-2017 SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 Gene3D G3DSA:3.40.190.10 40 120 3.4E-35 T 17-03-2017 SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 44 259 5.7E-61 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 SMART SM00062 42 261 7.4E-65 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS46110 d392d5ff19415b2213a261f08a16be04 264 ProSitePatterns PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 64 77 - T 17-03-2017 IPR018313 Solute-binding protein family 3, conserved site GO:0005215|GO:0006810 SHXM_RS14595 b99f7425a4479d7e586dd5cf53eec52f 321 SUPERFAMILY SSF51679 2 319 3.24E-63 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14595 b99f7425a4479d7e586dd5cf53eec52f 321 TIGRFAM TIGR03557 F420_G6P_family: F420-dependent oxidoreductase, G6PDH family 4 319 3.3E-143 T 17-03-2017 IPR019945 F420-dependent glucose-6-phosphate dehydrogenase-related SHXM_RS14595 b99f7425a4479d7e586dd5cf53eec52f 321 Pfam PF00296 Luciferase-like monooxygenase 5 293 9.2E-53 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14595 b99f7425a4479d7e586dd5cf53eec52f 321 Gene3D G3DSA:3.20.20.30 2 319 6.7E-68 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 ProSitePatterns PS00455 Putative AMP-binding domain signature. 138 149 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 Pfam PF13193 AMP-binding enzyme C-terminal domain 374 442 1.3E-12 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 Gene3D G3DSA:3.40.50.980 148 302 1.2E-26 T 17-03-2017 SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 Gene3D G3DSA:3.40.50.980 15 147 3.9E-12 T 17-03-2017 SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 SUPERFAMILY SSF56801 13 447 4.45E-83 T 17-03-2017 SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 Pfam PF00501 AMP-binding enzyme 12 365 8.1E-40 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS46550 f5b3d5bf74e416625e1ee83fee15f8dd 457 Gene3D G3DSA:3.30.300.30 360 447 5.0E-19 T 17-03-2017 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 SUPERFAMILY SSF56091 6 197 7.44E-43 T 17-03-2017 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 SUPERFAMILY SSF50249 200 338 1.2E-13 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 Pfam PF04679 ATP dependent DNA ligase C terminal region 215 329 5.5E-17 T 17-03-2017 IPR012309 DNA ligase, ATP-dependent, C-terminal GO:0003910|GO:0006281|GO:0006310 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 ProSitePatterns PS00697 ATP-dependent DNA ligase AMP-binding site. 27 35 - T 17-03-2017 IPR016059 DNA ligase, ATP-dependent, conserved site GO:0003909|GO:0051103 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 Gene3D G3DSA:3.30.470.30 32 148 7.6E-28 T 17-03-2017 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 Gene3D G3DSA:3.30.1490.70 3 31 1.6E-11 T 17-03-2017 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 Gene3D G3DSA:3.30.1490.70 156 198 1.6E-11 T 17-03-2017 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 Pfam PF01068 ATP dependent DNA ligase domain 11 197 1.9E-37 T 17-03-2017 IPR012310 DNA ligase, ATP-dependent, central GO:0003910|GO:0005524|GO:0006281|GO:0006310 SHXM_RS08290 ae308d911425937b0f7238dd4b95d0c7 358 Gene3D G3DSA:2.40.50.140 200 336 3.3E-14 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS21235 d13d8f62ff29e448b973a962143584bb 116 SUPERFAMILY SSF53927 12 110 3.42E-9 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS21235 d13d8f62ff29e448b973a962143584bb 116 Gene3D G3DSA:3.40.140.10 7 82 4.7E-7 T 17-03-2017 SHXM_RS23075 7e1c24cc55fca6fe0001a194499bcc07 372 SUPERFAMILY SSF53901 11 242 3.46E-30 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23075 7e1c24cc55fca6fe0001a194499bcc07 372 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 12 236 6.4E-15 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS23075 7e1c24cc55fca6fe0001a194499bcc07 372 Gene3D G3DSA:3.40.47.10 11 251 2.4E-24 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23075 7e1c24cc55fca6fe0001a194499bcc07 372 SUPERFAMILY SSF53901 220 369 4.93E-10 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS28950 1b526eece8a509b4c83f6edec52d8b3a 220 Pfam PF08044 Domain of unknown function (DUF1707) 20 72 2.6E-18 T 17-03-2017 IPR012551 Protein of unknown function DUF1707 SHXM_RS43575 ea8b10bf02635e9962619b91de03e8d0 367 Pfam PF03060 Nitronate monooxygenase 14 350 8.7E-47 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS43575 ea8b10bf02635e9962619b91de03e8d0 367 SUPERFAMILY SSF51412 93 309 1.42E-41 T 17-03-2017 SHXM_RS43575 ea8b10bf02635e9962619b91de03e8d0 367 SUPERFAMILY SSF51412 22 58 1.42E-41 T 17-03-2017 SHXM_RS43575 ea8b10bf02635e9962619b91de03e8d0 367 Gene3D G3DSA:3.20.20.70 106 345 1.6E-53 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS43575 ea8b10bf02635e9962619b91de03e8d0 367 Gene3D G3DSA:3.20.20.70 2 71 1.6E-53 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 Pfam PF02113 D-Ala-D-Ala carboxypeptidase 3 (S13) family 42 488 3.5E-126 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 Gene3D G3DSA:3.40.710.10 247 488 1.4E-63 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 TIGRFAM TIGR00666 PBP4: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase 67 469 1.7E-103 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 Gene3D G3DSA:3.40.710.10 54 94 1.4E-6 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 364 378 1.1E-28 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 79 98 1.1E-28 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 379 393 1.1E-28 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 307 329 1.1E-28 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 PRINTS PR00922 D-Ala-D-Ala carboxypeptidase 3 (S13) family signature 446 459 1.1E-28 T 17-03-2017 IPR000667 Peptidase S13, D-Ala-D-Ala carboxypeptidase C GO:0004185|GO:0006508 KEGG: 00550+3.4.16.4|MetaCyc: PWY-5265|MetaCyc: PWY-6471 SHXM_RS23795 21381bf0a3c2414c06fdf8f10429fbea 521 SUPERFAMILY SSF56601 39 482 2.96E-89 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS50060 fb56e986a9b5eedb77aeca394173f0fe 472 Pfam PF01547 Bacterial extracellular solute-binding protein 75 382 5.9E-27 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS50060 fb56e986a9b5eedb77aeca394173f0fe 472 SUPERFAMILY SSF53850 49 471 1.77E-56 T 17-03-2017 SHXM_RS50060 fb56e986a9b5eedb77aeca394173f0fe 472 Gene3D G3DSA:3.40.190.10 66 194 8.3E-14 T 17-03-2017 SHXM_RS50060 fb56e986a9b5eedb77aeca394173f0fe 472 Gene3D G3DSA:3.40.190.10 195 388 3.3E-32 T 17-03-2017 SHXM_RS41275 d4386dbe9c96e4f41e92fa81a5c2f00a 261 Pfam PF04199 Putative cyclase 22 197 4.8E-31 T 17-03-2017 IPR007325 Kynurenine formamidase GO:0004061|GO:0019441 KEGG: 00380+3.5.1.9|KEGG: 00630+3.5.1.9|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-7717|MetaCyc: PWY-7733|MetaCyc: PWY-7734 SHXM_RS41275 d4386dbe9c96e4f41e92fa81a5c2f00a 261 SUPERFAMILY SSF102198 19 258 1.96E-46 T 17-03-2017 SHXM_RS41275 d4386dbe9c96e4f41e92fa81a5c2f00a 261 Gene3D G3DSA:3.50.30.50 20 260 1.9E-52 T 17-03-2017 SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 SUPERFAMILY SSF51735 1 248 2.68E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 Gene3D G3DSA:3.40.50.720 1 247 5.5E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 246 6.3E-41 T 17-03-2017 SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 172 189 5.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 151 170 5.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 211 231 5.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS17425 7a49c1dd3e68e61c4c688b6b212afe92 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 5.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 SUPERFAMILY SSF53474 6 260 8.11E-42 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 Gene3D G3DSA:3.40.50.1820 5 264 4.3E-42 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 Pfam PF12697 Alpha/beta hydrolase family 29 251 4.3E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 PRINTS PR00111 Alpha/beta hydrolase fold signature 111 124 5.9E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 PRINTS PR00111 Alpha/beta hydrolase fold signature 53 68 5.9E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 PRINTS PR00111 Alpha/beta hydrolase fold signature 97 110 5.9E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS42630 920756d782c01eec22c88650c26b567d 269 PRINTS PR00111 Alpha/beta hydrolase fold signature 205 219 5.9E-9 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11285 9ee4205b1505ddefab80afff542f4e13 172 Gene3D G3DSA:3.40.50.720 12 158 1.4E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11285 9ee4205b1505ddefab80afff542f4e13 172 SUPERFAMILY SSF51735 12 157 3.7E-14 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40620 72340b1a4d73abe87c345b57c51f1afb 468 Pfam PF07063 Domain of unknown function (DUF1338) 6 406 2.4E-103 T 17-03-2017 IPR009770 Domain of unknown function DUF1338 SHXM_RS40620 72340b1a4d73abe87c345b57c51f1afb 468 SMART SM01150 8 406 1.9E-180 T 17-03-2017 IPR009770 Domain of unknown function DUF1338 SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 SMART SM00422 6 76 1.3E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 Pfam PF13411 MerR HTH family regulatory protein 7 75 1.7E-11 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 SUPERFAMILY SSF46955 6 108 1.72E-21 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 ProSitePatterns PS00552 MerR-type HTH domain signature. 9 31 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 SUPERFAMILY SSF55136 118 264 8.72E-14 T 17-03-2017 IPR011256 Regulatory factor, effector binding domain SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 Gene3D G3DSA:3.20.80.10 117 264 7.1E-14 T 17-03-2017 IPR011256 Regulatory factor, effector binding domain SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 Gene3D G3DSA:1.10.1660.10 6 109 1.4E-21 T 17-03-2017 SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 Pfam PF06445 GyrI-like small molecule binding domain 122 263 7.8E-17 T 17-03-2017 IPR029442 GyrI-like small molecule binding domain SHXM_RS33085 9a784fbe1a58a0573036558c577c9e54 268 SMART SM00871 116 264 8.4E-15 T 17-03-2017 IPR010499 Bacterial transcription activator, effector binding SHXM_RS32265 db9d6d9388786b62ac5173507f99870d 199 Gene3D G3DSA:3.40.630.30 15 186 7.5E-57 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS32265 db9d6d9388786b62ac5173507f99870d 199 Pfam PF13523 Acetyltransferase (GNAT) domain 23 165 1.1E-49 T 17-03-2017 SHXM_RS32265 db9d6d9388786b62ac5173507f99870d 199 SMART SM01006 20 67 6.0E-13 T 17-03-2017 IPR019432 Siderophore biosynthesis protein, conserved domain SHXM_RS32265 db9d6d9388786b62ac5173507f99870d 199 SUPERFAMILY SSF55729 15 181 1.18E-42 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS31385 7fcef7bbc4f0049218af42412f6b4181 306 Pfam PF04087 Domain of unknown function (DUF389) 145 289 1.4E-28 T 17-03-2017 IPR005240 Protein of unknown function DUF389 SHXM_RS31385 7fcef7bbc4f0049218af42412f6b4181 306 TIGRFAM TIGR00271 TIGR00271: uncharacterized hydrophobic domain 112 295 2.4E-57 T 17-03-2017 SHXM_RS25350 f1d6794162176cb68c4a8b87732e1565 386 SUPERFAMILY SSF54001 267 376 8.17E-43 T 17-03-2017 SHXM_RS25350 f1d6794162176cb68c4a8b87732e1565 386 Pfam PF00877 NlpC/P60 family 286 374 1.7E-25 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS25350 f1d6794162176cb68c4a8b87732e1565 386 Gene3D G3DSA:3.90.1720.10 265 375 1.3E-46 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS25585 fe872f814177a7c7629f680e34108e64 211 SUPERFAMILY SSF46689 9 87 5.99E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25585 fe872f814177a7c7629f680e34108e64 211 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 43 66 1.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25585 fe872f814177a7c7629f680e34108e64 211 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 35 1.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS25585 fe872f814177a7c7629f680e34108e64 211 Gene3D G3DSA:1.10.357.10 10 201 1.9E-31 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS25585 fe872f814177a7c7629f680e34108e64 211 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 68 5.5E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS50295 edfd388abecf5d26148de2a7c2cf1779 323 Gene3D G3DSA:3.40.190.10 264 302 3.2E-20 T 17-03-2017 SHXM_RS50295 edfd388abecf5d26148de2a7c2cf1779 323 Gene3D G3DSA:3.40.190.10 70 150 3.2E-20 T 17-03-2017 SHXM_RS50295 edfd388abecf5d26148de2a7c2cf1779 323 Gene3D G3DSA:3.40.190.10 151 257 1.2E-20 T 17-03-2017 SHXM_RS50295 edfd388abecf5d26148de2a7c2cf1779 323 SUPERFAMILY SSF53850 69 303 1.2E-40 T 17-03-2017 SHXM_RS50295 edfd388abecf5d26148de2a7c2cf1779 323 SMART SM00062 72 305 1.5E-26 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS50295 edfd388abecf5d26148de2a7c2cf1779 323 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 80 302 1.7E-40 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS42695 f26172436ccb0412356e6b91f1f966e6 313 SUPERFAMILY SSF56601 43 295 1.61E-59 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS42695 f26172436ccb0412356e6b91f1f966e6 313 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 39 281 5.3E-45 T 17-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 SHXM_RS42695 f26172436ccb0412356e6b91f1f966e6 313 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 72 83 4.8E-15 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS42695 f26172436ccb0412356e6b91f1f966e6 313 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 159 172 4.8E-15 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS42695 f26172436ccb0412356e6b91f1f966e6 313 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 126 143 4.8E-15 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS42695 f26172436ccb0412356e6b91f1f966e6 313 Gene3D G3DSA:3.40.710.10 43 296 8.7E-79 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS15270 0a4bf9719f5007fd6fefe02d32e4ef42 216 SUPERFAMILY SSF51735 1 203 4.64E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15270 0a4bf9719f5007fd6fefe02d32e4ef42 216 Pfam PF13460 NAD(P)H-binding 7 191 1.2E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15270 0a4bf9719f5007fd6fefe02d32e4ef42 216 Gene3D G3DSA:3.40.50.720 1 207 6.8E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27030 697d6c7f10772ee8a3b66428927cf7ba 111 Pfam PF02467 Transcription factor WhiB 7 69 8.6E-25 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS27030 697d6c7f10772ee8a3b66428927cf7ba 111 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 74 18.862 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS34180 493007b08c00ba32815de0a44557a41d 309 Gene3D G3DSA:3.40.50.1010 37 182 5.0E-15 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS34180 493007b08c00ba32815de0a44557a41d 309 Pfam PF01936 NYN domain 41 187 4.8E-9 T 17-03-2017 IPR021139 NYN domain, limkain-b1-type SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 Gene3D G3DSA:3.40.50.720 1 254 2.1E-83 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 SUPERFAMILY SSF51735 5 254 9.32E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 132 140 4.3E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 4.3E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 4.3E-12 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 253 1.9E-65 T 17-03-2017 SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 3.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 3.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 3.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 3.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31845 4d19cbfeda7820a2ba4db2f53ad47357 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 3.0E-43 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02265 9397fae423f90363213b6073f01fbe27 610 Pfam PF13454 FAD-NAD(P)-binding 1 167 6.3E-31 T 17-03-2017 SHXM_RS14985 22bdc3ca0642cdd0ef588860049dfb09 154 Pfam PF12802 MarR family 39 98 9.5E-12 T 17-03-2017 SHXM_RS14985 22bdc3ca0642cdd0ef588860049dfb09 154 SMART SM00347 33 135 7.1E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS14985 22bdc3ca0642cdd0ef588860049dfb09 154 Gene3D G3DSA:1.10.10.10 4 152 3.3E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS14985 22bdc3ca0642cdd0ef588860049dfb09 154 SUPERFAMILY SSF46785 6 150 2.82E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27285 d5fbc52e0e79a8f2a345c9f6c440e7b0 137 Gene3D G3DSA:1.10.10.10 22 88 2.0E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27285 d5fbc52e0e79a8f2a345c9f6c440e7b0 137 SUPERFAMILY SSF46785 22 131 3.5E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27285 d5fbc52e0e79a8f2a345c9f6c440e7b0 137 Pfam PF03965 Penicillinase repressor 22 129 9.8E-23 T 17-03-2017 IPR005650 BlaI transcriptional regulatory family GO:0003677|GO:0045892 SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 8 247 7.3E-49 T 17-03-2017 SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 SUPERFAMILY SSF51735 2 248 1.58E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 132 148 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 179 196 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 158 177 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 1.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 76 87 1.5E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 158 177 1.5E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 138 146 1.5E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 Gene3D G3DSA:3.40.50.720 2 250 1.6E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41155 2820194d302526df57ba8770a7a29538 253 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 145 173 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS01940 4d1e98e86cc506cdf353ef6ae37dbcb6 327 SUPERFAMILY SSF161098 115 313 2.06E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01940 4d1e98e86cc506cdf353ef6ae37dbcb6 327 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 134 325 2.6E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36260 6c977433519b7812c1ae3dd066d9603b 192 Gene3D G3DSA:3.40.50.300 11 186 8.7E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36260 6c977433519b7812c1ae3dd066d9603b 192 Pfam PF03029 Conserved hypothetical ATP binding protein 20 187 1.6E-27 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS36260 6c977433519b7812c1ae3dd066d9603b 192 SUPERFAMILY SSF52540 15 186 9.02E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03785 8d9f11e1da808b1d30463853b068ee12 353 SUPERFAMILY SSF50182 168 234 5.23E-12 T 17-03-2017 IPR010920 LSM domain SHXM_RS03785 8d9f11e1da808b1d30463853b068ee12 353 SUPERFAMILY SSF82861 85 167 1.96E-12 T 17-03-2017 IPR011014 Mechanosensitive ion channel MscS, transmembrane-2 GO:0016020 SHXM_RS03785 8d9f11e1da808b1d30463853b068ee12 353 Pfam PF00924 Mechanosensitive ion channel 126 330 1.2E-39 T 17-03-2017 IPR006685 Mechanosensitive ion channel MscS GO:0016020|GO:0055085 SHXM_RS03785 8d9f11e1da808b1d30463853b068ee12 353 Gene3D G3DSA:3.30.70.100 243 328 5.0E-12 T 17-03-2017 SHXM_RS03785 8d9f11e1da808b1d30463853b068ee12 353 SUPERFAMILY SSF82689 242 341 1.44E-17 T 17-03-2017 IPR011066 Mechanosensitive ion channel MscS, C-terminal GO:0016020 SHXM_RS03785 8d9f11e1da808b1d30463853b068ee12 353 Gene3D G3DSA:2.30.30.60 186 234 3.0E-10 T 17-03-2017 SHXM_RS42715 5d09f552885677a2ee323194fc30b5f7 183 Gene3D G3DSA:1.10.287.1060 67 150 9.5E-5 T 17-03-2017 SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 Gene3D G3DSA:1.10.1740.10 6 74 1.2E-9 T 17-03-2017 SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 Gene3D G3DSA:1.10.10.10 105 166 2.6E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 16 166 8.3E-14 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 Pfam PF08281 Sigma-70, region 4 113 164 3.7E-10 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 SUPERFAMILY SSF88946 5 71 2.51E-10 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 SUPERFAMILY SSF88659 104 166 6.73E-12 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30000 b8a9bee4873db33cad727366e91666e5 406 Pfam PF04542 Sigma-70 region 2 17 73 6.5E-9 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS41985 67460e5b331fd2afc9606c3f5e3f8ca9 337 Pfam PF01032 FecCD transport family 16 332 2.6E-90 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS41985 67460e5b331fd2afc9606c3f5e3f8ca9 337 SUPERFAMILY SSF81345 3 332 5.1E-77 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS41985 67460e5b331fd2afc9606c3f5e3f8ca9 337 Gene3D G3DSA:1.10.3470.10 4 336 6.2E-104 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS12865 2888dfc70d1b2c372b5ae23c0a29f2e9 329 Gene3D G3DSA:3.20.20.100 18 313 4.4E-37 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS12865 2888dfc70d1b2c372b5ae23c0a29f2e9 329 SUPERFAMILY SSF51430 49 312 7.46E-39 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS12865 2888dfc70d1b2c372b5ae23c0a29f2e9 329 Pfam PF00248 Aldo/keto reductase family 47 311 3.9E-31 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS28010 78b9e136ed8329663d9f252073a48c02 495 Pfam PF09594 Protein of unknown function (DUF2029) 121 366 5.2E-13 T 17-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 SHXM_RS28010 78b9e136ed8329663d9f252073a48c02 495 PIRSF PIRSF010361 12 471 1.3E-146 T 17-03-2017 IPR016570 Uncharacterised conserved protein UCP010361, membrane SHXM_RS09550 6d6efbab62bbe2a8703899b34c9f5bc1 260 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 7 249 1.3E-19 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS09550 6d6efbab62bbe2a8703899b34c9f5bc1 260 Gene3D G3DSA:3.60.10.10 35 172 5.1E-11 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS09550 6d6efbab62bbe2a8703899b34c9f5bc1 260 SUPERFAMILY SSF56219 3 258 4.19E-32 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS09550 6d6efbab62bbe2a8703899b34c9f5bc1 260 Gene3D G3DSA:3.60.10.10 173 254 9.6E-4 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS11230 3bc8a485c99133cd2f4a529784fc6e5b 497 Gene3D G3DSA:3.40.50.1820 7 485 3.0E-122 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11230 3bc8a485c99133cd2f4a529784fc6e5b 497 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 180 195 - T 17-03-2017 IPR019826 Carboxylesterase type B, active site SHXM_RS11230 3bc8a485c99133cd2f4a529784fc6e5b 497 SUPERFAMILY SSF53474 7 479 2.73E-105 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11230 3bc8a485c99133cd2f4a529784fc6e5b 497 Pfam PF00135 Carboxylesterase family 7 481 4.7E-94 T 17-03-2017 IPR002018 Carboxylesterase, type B SHXM_RS17945 658607c22b4cfda859d3fdea55d5cbc9 311 SUPERFAMILY SSF52540 29 178 3.29E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17945 658607c22b4cfda859d3fdea55d5cbc9 311 PIRSF PIRSF005052 28 311 4.8E-112 T 17-03-2017 IPR005337 RapZ-like family GO:0005524 SHXM_RS17945 658607c22b4cfda859d3fdea55d5cbc9 311 Gene3D G3DSA:3.40.50.300 26 180 1.7E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17945 658607c22b4cfda859d3fdea55d5cbc9 311 Pfam PF03668 P-loop ATPase protein family 29 311 9.2E-112 T 17-03-2017 IPR005337 RapZ-like family GO:0005524 SHXM_RS17945 658607c22b4cfda859d3fdea55d5cbc9 311 Hamap MF_00636 RNase adapter protein RapZ [rapZ]. 28 310 41.435 T 17-03-2017 IPR005337 RapZ-like family GO:0005524 SHXM_RS39960 9b0fb6bea7f6d12085b18864a8239857 108 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 21 36 5.8E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS39960 9b0fb6bea7f6d12085b18864a8239857 108 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 54 69 5.8E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS39960 9b0fb6bea7f6d12085b18864a8239857 108 SUPERFAMILY SSF46785 14 98 2.27E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39960 9b0fb6bea7f6d12085b18864a8239857 108 SMART SM00418 19 98 2.1E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS39960 9b0fb6bea7f6d12085b18864a8239857 108 Pfam PF12840 Helix-turn-helix domain 19 75 1.9E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39960 9b0fb6bea7f6d12085b18864a8239857 108 Gene3D G3DSA:1.10.10.10 19 100 1.6E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47270 8377f1538dc979bd440b868514376b02 69 Gene3D G3DSA:3.60.15.10 14 57 4.1E-7 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS27615 ac69ff13660a9b9631841569ff962ac8 322 Pfam PF02810 SEC-C motif 28 44 5.4E-8 T 17-03-2017 IPR004027 SEC-C motif SHXM_RS27615 ac69ff13660a9b9631841569ff962ac8 322 Gene3D G3DSA:3.10.450.50 19 44 1.0E-7 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS27615 ac69ff13660a9b9631841569ff962ac8 322 SUPERFAMILY SSF103642 25 44 1.1E-6 T 17-03-2017 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 SUPERFAMILY SSF46785 3 62 1.22E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 SUPERFAMILY SSF50037 130 229 8.7E-24 T 17-03-2017 IPR008988 Transcriptional repressor, C-terminal SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 SMART SM00899 153 229 3.4E-6 T 17-03-2017 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 Pfam PF02742 Iron dependent repressor, metal binding and dimerisation domain 65 133 3.5E-29 T 17-03-2017 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 Gene3D G3DSA:1.10.60.10 75 133 9.2E-30 T 17-03-2017 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 Pfam PF04023 FeoA domain 162 228 4.0E-7 T 17-03-2017 IPR007167 Ferrous iron transporter FeoA domain GO:0046914 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 SUPERFAMILY SSF47979 65 137 6.41E-26 T 17-03-2017 IPR001367 Iron dependent repressor, metal binding and dimerisation domain GO:0046914|GO:0046983 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 SMART SM00529 26 125 4.1E-47 T 17-03-2017 IPR022689 Iron dependent repressor GO:0003700|GO:0006355|GO:0046914 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 Gene3D G3DSA:1.10.10.10 2 73 5.0E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 Pfam PF01325 Iron dependent repressor, N-terminal DNA binding domain 4 62 3.4E-19 T 17-03-2017 IPR022687 DTXR-type HTH domain GO:0003677 SHXM_RS25560 29a64e63063763768241b7d716cf3e17 230 Gene3D G3DSA:2.30.30.90 134 229 1.0E-31 T 17-03-2017 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 ProSitePatterns PS00860 GTP cyclohydrolase I signature 2. 127 137 - T 17-03-2017 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 SUPERFAMILY SSF55620 16 198 3.26E-76 T 17-03-2017 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 Gene3D G3DSA:3.30.1130.10 70 199 3.0E-59 T 17-03-2017 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 ProSitePatterns PS00859 GTP cyclohydrolase I signature 1. 77 93 - T 17-03-2017 IPR018234 GTP cyclohydrolase I, conserved site GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 Pfam PF01227 GTP cyclohydrolase I 22 198 6.3E-77 T 17-03-2017 IPR020602 GTP cyclohydrolase I domain KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 TIGRFAM TIGR00063 folE: GTP cyclohydrolase I 22 198 5.8E-72 T 17-03-2017 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 Hamap MF_00223 GTP cyclohydrolase 1 [folE]. 17 199 41.756 T 17-03-2017 IPR001474 GTP cyclohydrolase I GO:0003934|GO:0005737|GO:0046654 KEGG: 00790+3.5.4.16|MetaCyc: PWY-5663|MetaCyc: PWY-5664|MetaCyc: PWY-6147|MetaCyc: PWY-6703|MetaCyc: PWY-6983|MetaCyc: PWY-7442|Reactome: R-HSA-1474151 SHXM_RS26445 d2a6c5a47a8d7e90e916c14feb34fc0f 201 Gene3D G3DSA:1.10.286.10 16 67 4.6E-24 T 17-03-2017 SHXM_RS02935 332e1550379065deb7610e313bd8c007 291 SUPERFAMILY SSF51679 8 284 4.19E-55 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS02935 332e1550379065deb7610e313bd8c007 291 Pfam PF00296 Luciferase-like monooxygenase 7 258 1.2E-41 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS02935 332e1550379065deb7610e313bd8c007 291 Gene3D G3DSA:3.20.20.30 14 263 3.2E-61 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS17820 f7bab6823b160faa17e12c46506bda34 107 Gene3D G3DSA:2.102.10.10 2 105 1.5E-35 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS17820 f7bab6823b160faa17e12c46506bda34 107 SUPERFAMILY SSF50022 4 105 9.56E-33 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS17820 f7bab6823b160faa17e12c46506bda34 107 Pfam PF00355 Rieske [2Fe-2S] domain 6 91 3.0E-21 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS11745 73cc90c9b7196a702481f54b46b98642 317 Gene3D G3DSA:3.30.200.20 63 143 2.3E-10 T 17-03-2017 SHXM_RS11745 73cc90c9b7196a702481f54b46b98642 317 SUPERFAMILY SSF56112 71 315 2.92E-37 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS11745 73cc90c9b7196a702481f54b46b98642 317 Pfam PF01636 Phosphotransferase enzyme family 87 307 3.3E-21 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS11745 73cc90c9b7196a702481f54b46b98642 317 Gene3D G3DSA:3.90.1200.10 147 315 1.8E-34 T 17-03-2017 SHXM_RS47725 ddc7c812ad31589f48d6b56869c94cbf 209 SUPERFAMILY SSF48498 81 205 8.89E-14 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47725 ddc7c812ad31589f48d6b56869c94cbf 209 Pfam PF00440 Bacterial regulatory proteins, tetR family 10 56 4.3E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47725 ddc7c812ad31589f48d6b56869c94cbf 209 SUPERFAMILY SSF46689 4 73 3.64E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47725 ddc7c812ad31589f48d6b56869c94cbf 209 Gene3D G3DSA:1.10.357.10 6 206 6.4E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47725 ddc7c812ad31589f48d6b56869c94cbf 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 31 54 8.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47725 ddc7c812ad31589f48d6b56869c94cbf 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 10 23 8.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03050 4137c89540fc7d42f4e182b1ed3e9d53 369 SUPERFAMILY SSF55961 155 349 1.51E-8 T 17-03-2017 SHXM_RS03050 4137c89540fc7d42f4e182b1ed3e9d53 369 SUPERFAMILY SSF50022 34 145 9.3E-30 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS03050 4137c89540fc7d42f4e182b1ed3e9d53 369 Gene3D G3DSA:2.102.10.10 38 148 3.8E-25 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS03050 4137c89540fc7d42f4e182b1ed3e9d53 369 Pfam PF00355 Rieske [2Fe-2S] domain 40 117 4.4E-15 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS45655 69efe82f99f24fda16ff09e735c82078 267 Gene3D G3DSA:3.40.50.80 137 265 9.0E-44 T 17-03-2017 SHXM_RS45655 69efe82f99f24fda16ff09e735c82078 267 Pfam PF04954 Siderophore-interacting protein 142 262 2.1E-35 T 17-03-2017 IPR007037 Siderophore-interacting protein SHXM_RS45655 69efe82f99f24fda16ff09e735c82078 267 SUPERFAMILY SSF63380 12 127 2.16E-5 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS45655 69efe82f99f24fda16ff09e735c82078 267 Gene3D G3DSA:2.40.30.10 9 130 7.9E-29 T 17-03-2017 SHXM_RS45655 69efe82f99f24fda16ff09e735c82078 267 Pfam PF08021 Siderophore-interacting FAD-binding domain 18 130 6.8E-30 T 17-03-2017 IPR013113 FAD-binding 9, siderophore-interacting SHXM_RS18430 c22d64be84f25ba4f0be1da482c55953 246 SUPERFAMILY SSF88697 5 221 3.23E-36 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS18430 c22d64be84f25ba4f0be1da482c55953 246 Pfam PF02190 ATP-dependent protease La (LON) substrate-binding domain 6 221 1.2E-29 T 17-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 SHXM_RS18430 c22d64be84f25ba4f0be1da482c55953 246 SMART SM00464 5 222 4.4E-39 T 17-03-2017 IPR003111 ATP-dependent protease La (LON), substrate-binding domain GO:0004176|GO:0006508 SHXM_RS20425 ff55b52fc26848e9b5f8d62619e0a5dd 370 Pfam PF00544 Pectate lyase 132 303 2.1E-42 T 17-03-2017 IPR002022 Pectate lyase/Amb allergen SHXM_RS20425 ff55b52fc26848e9b5f8d62619e0a5dd 370 SMART SM00656 97 309 1.5E-37 T 17-03-2017 IPR002022 Pectate lyase/Amb allergen SHXM_RS20425 ff55b52fc26848e9b5f8d62619e0a5dd 370 SUPERFAMILY SSF51126 85 370 5.13E-77 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20425 ff55b52fc26848e9b5f8d62619e0a5dd 370 Gene3D G3DSA:2.160.20.10 75 370 7.3E-92 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS13035 21715d00cb3defc531d16a0ea73c6975 190 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 23 186 1.0E-25 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS13035 21715d00cb3defc531d16a0ea73c6975 190 Gene3D G3DSA:3.40.50.1240 4 186 1.2E-24 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS13035 21715d00cb3defc531d16a0ea73c6975 190 SMART SM00855 4 151 1.7E-8 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS13035 21715d00cb3defc531d16a0ea73c6975 190 SUPERFAMILY SSF53254 4 186 3.64E-31 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS24260 fef69eb7c51e0ee75a5e0fa1071b127d 564 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 443 534 2.8E-10 T 17-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain SHXM_RS24260 fef69eb7c51e0ee75a5e0fa1071b127d 564 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 169 332 1.3E-44 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24260 fef69eb7c51e0ee75a5e0fa1071b127d 564 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 169 331 1.4E-40 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24215 6362e27fe3edcacad0dcdd89ea39923c 87 Pfam PF02467 Transcription factor WhiB 19 82 6.1E-27 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS24215 6362e27fe3edcacad0dcdd89ea39923c 87 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 87 18.896 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 Gene3D G3DSA:1.10.10.10 2 70 5.3E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 Pfam PF09339 IclR helix-turn-helix domain 4 52 1.9E-13 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 Pfam PF01614 Bacterial transcriptional regulator 117 241 7.1E-29 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 SMART SM00346 2 89 1.5E-24 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 SUPERFAMILY SSF46785 3 72 3.12E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 Gene3D G3DSA:3.30.450.40 71 244 4.1E-56 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS33370 c1bdcae991bcae1202feaf0d08aae5ad 277 SUPERFAMILY SSF55781 57 243 2.81E-48 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 Pfam PF00196 Bacterial regulatory proteins, luxR family 367 422 2.4E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 SMART SM00421 365 422 6.5E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 Gene3D G3DSA:1.10.10.10 356 425 3.5E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 ProSitePatterns PS00622 LuxR-type HTH domain signature. 382 409 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 398 410 4.2E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 382 398 4.2E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 368 382 4.2E-13 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 SUPERFAMILY SSF46894 356 426 9.52E-20 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS04605 6e6f8c14cafa8f308fc87251f5447324 430 SUPERFAMILY SSF55874 282 354 6.21E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 TIGRFAM TIGR01428 HAD_type_II: haloacid dehalogenase, type II 7 200 5.4E-48 T 17-03-2017 IPR006328 Haloacid dehalogenase, type II GO:0008152|GO:0019120 KEGG: 00361+3.8.1.2|KEGG: 00625+3.8.1.2|MetaCyc: PWY-7425 SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 Pfam PF13419 Haloacid dehalogenase-like hydrolase 97 186 5.1E-8 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 154 174 7.2E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 6 17 7.2E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 107 120 7.2E-6 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 TIGRFAM TIGR01493 HAD-SF-IA-v2: HAD hydrolase, family IA, variant 2 8 183 5.1E-16 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 SUPERFAMILY SSF56784 6 220 1.62E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12065 88b5f386d5bdf81656487d04e8e61c58 222 Gene3D G3DSA:3.40.50.1000 83 217 6.7E-24 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS22020 fbf1cd9306e1797a1ab847fae97aa432 536 Gene3D G3DSA:3.40.50.300 57 103 5.6E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22020 fbf1cd9306e1797a1ab847fae97aa432 536 Gene3D G3DSA:3.40.50.300 156 235 5.6E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22020 fbf1cd9306e1797a1ab847fae97aa432 536 SUPERFAMILY SSF52540 39 251 1.44E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22020 fbf1cd9306e1797a1ab847fae97aa432 536 Pfam PF00350 Dynamin family 63 194 4.2E-8 T 17-03-2017 IPR022812 Dynamin superfamily SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 6 64 1.2E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 SUPERFAMILY SSF53850 99 291 6.7E-6 T 17-03-2017 SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 SUPERFAMILY SSF46785 5 88 2.04E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 21 32 5.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 32 42 5.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 42 53 5.8E-6 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS44080 fb869c0508d0b0b0b85845e0592b55c0 307 Gene3D G3DSA:1.10.10.10 5 89 2.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48425 44348e0f84159e28a180ca1d4ec62e85 306 Gene3D G3DSA:1.10.3720.10 66 265 2.1E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48425 44348e0f84159e28a180ca1d4ec62e85 306 SUPERFAMILY SSF161098 70 250 5.07E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48425 44348e0f84159e28a180ca1d4ec62e85 306 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 95 265 2.3E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 PRINTS PR01036 Tetracycline resistance protein TetB signature 150 174 2.0E-12 T 17-03-2017 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 PRINTS PR01036 Tetracycline resistance protein TetB signature 29 53 2.0E-12 T 17-03-2017 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 PRINTS PR01036 Tetracycline resistance protein TetB signature 89 111 2.0E-12 T 17-03-2017 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 PRINTS PR01036 Tetracycline resistance protein TetB signature 413 432 2.0E-12 T 17-03-2017 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 Gene3D G3DSA:1.20.1250.20 270 433 3.6E-14 T 17-03-2017 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 Gene3D G3DSA:1.20.1250.20 471 496 3.6E-14 T 17-03-2017 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 ProSitePatterns PS00216 Sugar transport proteins signature 1. 80 96 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 Pfam PF07690 Major Facilitator Superfamily 30 422 8.7E-54 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 SUPERFAMILY SSF103473 260 432 5.36E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 SUPERFAMILY SSF103473 17 211 5.36E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 SUPERFAMILY SSF103473 470 497 5.36E-65 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27400 81a0a27281641f677e5f45b078805df7 507 Gene3D G3DSA:1.20.1250.20 27 205 7.5E-32 T 17-03-2017 SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 Pfam PF16697 Inner membrane component of T3SS, cytoplasmic domain 135 225 1.1E-15 T 17-03-2017 IPR032030 YscD, cytoplasmic domain SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 Gene3D G3DSA:3.40.50.300 1470 1550 5.4E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 Gene3D G3DSA:3.40.50.300 1279 1376 5.4E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 SUPERFAMILY SSF49879 127 235 1.21E-24 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 SMART SM00382 1286 1554 8.1E-5 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 Pfam PF01580 FtsK/SpoIIIE family 1281 1385 3.3E-14 T 17-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 Gene3D G3DSA:2.60.200.20 129 232 3.0E-24 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 SUPERFAMILY SSF52540 1275 1552 1.17E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23880 67b7457d6593922469027a6ebbc4e435 1693 SMART SM00240 151 202 1.6E-9 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS05005 add18f71eef15b13e0a3ae2b41536d39 394 Gene3D G3DSA:3.40.220.10 271 390 2.6E-10 T 17-03-2017 SHXM_RS05005 add18f71eef15b13e0a3ae2b41536d39 394 SUPERFAMILY SSF52949 206 389 5.55E-12 T 17-03-2017 SHXM_RS01815 c8b754fe797a72eb0c7d6c75a9e6b869 278 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 92 271 1.8E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01815 c8b754fe797a72eb0c7d6c75a9e6b869 278 SUPERFAMILY SSF161098 6 278 2.88E-73 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01815 c8b754fe797a72eb0c7d6c75a9e6b869 278 Gene3D G3DSA:1.10.3720.10 5 265 7.8E-64 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33035 7e281dbe6ed7e4d86fee3360904ed699 876 Pfam PF00672 HAMP domain 345 429 4.5E-10 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS33035 7e281dbe6ed7e4d86fee3360904ed699 876 SUPERFAMILY SSF55874 540 660 6.16E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33035 7e281dbe6ed7e4d86fee3360904ed699 876 SMART SM00387 548 663 6.2E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33035 7e281dbe6ed7e4d86fee3360904ed699 876 SMART SM00304 364 436 1.2E-4 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS33035 7e281dbe6ed7e4d86fee3360904ed699 876 Gene3D G3DSA:3.30.565.10 510 662 3.7E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS33035 7e281dbe6ed7e4d86fee3360904ed699 876 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 551 660 6.8E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS48360 fa0aeb3662914aa80e0292810bc17ef7 326 Pfam PF00892 EamA-like transporter family 14 144 1.1E-11 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS48360 fa0aeb3662914aa80e0292810bc17ef7 326 SUPERFAMILY SSF103481 50 149 4.45E-5 T 17-03-2017 SHXM_RS21620 b6f59cc49c22badabc7a22cceb58bb07 640 TIGRFAM TIGR03960 rSAM_fuse_unch: radical SAM family uncharacterized protein 12 618 1.0E-212 T 17-03-2017 IPR023862 Conserved hypothetical protein CHP03960, radical SAM SHXM_RS21620 b6f59cc49c22badabc7a22cceb58bb07 640 SMART SM00729 264 487 2.7E-30 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS21620 b6f59cc49c22badabc7a22cceb58bb07 640 SUPERFAMILY SSF102114 232 635 1.57E-51 T 17-03-2017 SHXM_RS21620 b6f59cc49c22badabc7a22cceb58bb07 640 Gene3D G3DSA:3.80.30.20 263 492 7.8E-45 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS21620 b6f59cc49c22badabc7a22cceb58bb07 640 Pfam PF04055 Radical SAM superfamily 268 433 2.4E-15 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS29055 48bdf469826779616fc275ac18f8f6c3 191 Pfam PF00692 dUTPase 70 173 1.5E-9 T 17-03-2017 IPR008180 Deoxyuridine triphosphate nucleotidohydrolase/Deoxycytidine triphosphate deaminase GO:0016787|GO:0046080 SHXM_RS29055 48bdf469826779616fc275ac18f8f6c3 191 Hamap MF_00146 Deoxycytidine triphosphate deaminase [dcd]. 1 182 34.406 T 17-03-2017 IPR011962 Deoxycytidine triphosphate deaminase GO:0006229|GO:0008829 KEGG: 00240+3.5.4.13|MetaCyc: PWY-7187 SHXM_RS29055 48bdf469826779616fc275ac18f8f6c3 191 SUPERFAMILY SSF51283 2 184 4.32E-56 T 17-03-2017 IPR029054 dUTPase-like SHXM_RS29055 48bdf469826779616fc275ac18f8f6c3 191 Gene3D G3DSA:2.70.40.10 2 184 2.5E-67 T 17-03-2017 IPR029054 dUTPase-like SHXM_RS29055 48bdf469826779616fc275ac18f8f6c3 191 TIGRFAM TIGR02274 dCTP_deam: deoxycytidine triphosphate deaminase 3 181 8.8E-64 T 17-03-2017 IPR011962 Deoxycytidine triphosphate deaminase GO:0006229|GO:0008829 KEGG: 00240+3.5.4.13|MetaCyc: PWY-7187 SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 24 87 5.6E-7 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 SUPERFAMILY SSF51735 112 284 2.27E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 Pfam PF13602 Zinc-binding dehydrogenase 179 310 1.2E-19 T 17-03-2017 SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 Gene3D G3DSA:3.40.50.720 141 238 8.4E-24 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 SMART SM00829 7 310 1.8E-15 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 SUPERFAMILY SSF50129 1 108 8.07E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 SUPERFAMILY SSF50129 136 145 8.07E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS11115 3167bc909bf705f54376612839ac6a98 313 Gene3D G3DSA:3.90.180.10 1 140 1.0E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 Gene3D G3DSA:3.30.300.30 443 539 2.8E-27 T 17-03-2017 SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 SUPERFAMILY SSF56801 13 540 4.32E-141 T 17-03-2017 SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 Gene3D G3DSA:2.30.38.10 359 434 5.8E-17 T 17-03-2017 SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 Gene3D G3DSA:3.40.50.980 205 347 1.9E-30 T 17-03-2017 SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 Gene3D G3DSA:3.40.50.980 24 204 6.8E-41 T 17-03-2017 SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 Pfam PF00501 AMP-binding enzyme 31 443 1.8E-88 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 Pfam PF13193 AMP-binding enzyme C-terminal domain 453 528 4.3E-15 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS38395 a36a3e2c6f92283bbd846178db3c67b6 556 ProSitePatterns PS00455 Putative AMP-binding domain signature. 200 211 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS42800 bc161f389505b8bc58dda416d934d033 64 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 3.3E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS42800 bc161f389505b8bc58dda416d934d033 64 PRINTS PR00352 3Fe-4S ferredoxin signature 16 26 3.3E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS42800 bc161f389505b8bc58dda416d934d033 64 PRINTS PR00352 3Fe-4S ferredoxin signature 5 16 3.3E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS42800 bc161f389505b8bc58dda416d934d033 64 Gene3D G3DSA:3.30.70.20 2 64 7.8E-16 T 17-03-2017 SHXM_RS42800 bc161f389505b8bc58dda416d934d033 64 SUPERFAMILY SSF54862 2 62 5.54E-12 T 17-03-2017 SHXM_RS42800 bc161f389505b8bc58dda416d934d033 64 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 5 62 2.7E-12 T 17-03-2017 SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 SUPERFAMILY SSF46785 279 350 9.09E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 Pfam PF12840 Helix-turn-helix domain 281 336 1.1E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 281 296 2.0E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 313 328 2.0E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 328 343 2.0E-9 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 Gene3D G3DSA:1.10.10.10 267 357 1.6E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21775 2541bb5e4309f43d3ff6fb8f86a78432 361 SMART SM00418 279 357 7.0E-20 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS28660 38e19795d0b0146f584dbcdec227c766 215 SUPERFAMILY SSF48498 80 197 6.47E-20 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS28660 38e19795d0b0146f584dbcdec227c766 215 Pfam PF16859 Bacterial transcriptional repressor C-terminal 80 189 1.3E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS28660 38e19795d0b0146f584dbcdec227c766 215 Gene3D G3DSA:1.10.357.10 63 199 5.0E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS28660 38e19795d0b0146f584dbcdec227c766 215 SUPERFAMILY SSF46689 14 74 8.72E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS28660 38e19795d0b0146f584dbcdec227c766 215 Gene3D G3DSA:1.10.10.60 13 61 3.1E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49550 367fac04d618987d0a1d85c8fbbe533a 328 SUPERFAMILY SSF161098 91 317 4.71E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49550 367fac04d618987d0a1d85c8fbbe533a 328 Gene3D G3DSA:1.10.3720.10 96 325 1.8E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49550 367fac04d618987d0a1d85c8fbbe533a 328 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 121 318 6.5E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48525 254f92584c0609bbd750e65608caeddf 336 Pfam PF13407 Periplasmic binding protein domain 58 309 3.1E-48 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS48525 254f92584c0609bbd750e65608caeddf 336 Gene3D G3DSA:3.40.50.2300 56 171 4.8E-30 T 17-03-2017 SHXM_RS48525 254f92584c0609bbd750e65608caeddf 336 SUPERFAMILY SSF53822 57 331 2.69E-60 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS48525 254f92584c0609bbd750e65608caeddf 336 Gene3D G3DSA:3.40.50.2300 172 320 9.5E-33 T 17-03-2017 SHXM_RS04330 da340b8a85931710a4a826ad47eabce7 248 Gene3D G3DSA:3.40.50.1820 2 245 2.3E-77 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04330 da340b8a85931710a4a826ad47eabce7 248 Pfam PF00975 Thioesterase domain 34 189 7.0E-19 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS04330 da340b8a85931710a4a826ad47eabce7 248 SUPERFAMILY SSF53474 15 245 1.62E-36 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04330 da340b8a85931710a4a826ad47eabce7 248 SMART SM00824 Thioesterase 35 244 2.3E-114 T 17-03-2017 IPR020802 Polyketide synthase, thioesterase domain GO:0009058|GO:0016788 SHXM_RS06755 c1a681a6acdca8b6945c7d669d830192 154 Pfam PF09391 Protein of unknown function (DUF2000) 23 154 2.1E-40 T 17-03-2017 IPR018988 Protein of unknown function DUF2000 SHXM_RS06755 c1a681a6acdca8b6945c7d669d830192 154 Gene3D G3DSA:3.40.1490.10 22 154 4.6E-24 T 17-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 SHXM_RS06755 c1a681a6acdca8b6945c7d669d830192 154 SUPERFAMILY SSF102462 21 154 1.15E-30 T 17-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 SHXM_RS06755 c1a681a6acdca8b6945c7d669d830192 154 PIRSF PIRSF033736 15 154 4.0E-29 T 17-03-2017 IPR017021 Uncharacterised conserved protein UCP033763 SHXM_RS36525 81e79e8447ca65da170ac086c2076dfc 223 SMART SM00943 27 211 1.7E-25 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS36525 81e79e8447ca65da170ac086c2076dfc 223 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 29 202 2.9E-12 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS13735 1d055d7d24447b8d3b760dae87d4c8fc 312 Gene3D G3DSA:3.20.20.370 3 279 7.7E-82 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS13735 1d055d7d24447b8d3b760dae87d4c8fc 312 SUPERFAMILY SSF88713 4 279 3.46E-67 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS13735 1d055d7d24447b8d3b760dae87d4c8fc 312 Pfam PF01522 Polysaccharide deacetylase 50 157 3.2E-24 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS35805 382d304052efb994bf1325ec8c3cb938 184 Gene3D G3DSA:1.20.120.450 17 183 2.6E-35 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS35805 382d304052efb994bf1325ec8c3cb938 184 SUPERFAMILY SSF109854 25 179 1.83E-36 T 17-03-2017 SHXM_RS35805 382d304052efb994bf1325ec8c3cb938 184 Pfam PF04978 Protein of unknown function (DUF664) 32 180 3.2E-36 T 17-03-2017 IPR007061 Protein of unknown function DUF664 SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 SMART SM00345 34 95 8.0E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 Gene3D G3DSA:1.10.10.10 31 99 2.9E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 SUPERFAMILY SSF48008 117 248 1.15E-22 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 Gene3D G3DSA:1.20.120.530 117 247 2.5E-20 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 67 83 5.1E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 53 67 5.1E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 Pfam PF00392 Bacterial regulatory proteins, gntR family 33 95 1.6E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 Pfam PF07729 FCD domain 121 240 7.1E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 SMART SM00895 120 241 4.2E-19 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS13205 d9ab9e7d3a7e05961ea9361674154479 251 SUPERFAMILY SSF46785 26 99 2.89E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40870 012df9463ba00a0bdb5e8d438833ced0 73 Pfam PF09489 Probable cobalt transporter subunit (CbtB) 24 73 2.5E-13 T 17-03-2017 IPR012667 Cobalt transporter subunit CbtB, putative SHXM_RS42920 012df9463ba00a0bdb5e8d438833ced0 73 Pfam PF09489 Probable cobalt transporter subunit (CbtB) 24 73 2.5E-13 T 17-03-2017 IPR012667 Cobalt transporter subunit CbtB, putative SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 SUPERFAMILY SSF51735 5 244 5.9E-79 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 Gene3D G3DSA:3.40.50.720 3 245 1.5E-82 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 3.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 3.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 3.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 230 3.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 77 88 3.2E-42 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 2.3E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 2.3E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 77 88 2.3E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS13955 dfa30d0b7bf2052f1f3301ab579b9329 248 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 244 1.4E-65 T 17-03-2017 SHXM_RS29645 bd702e12530baf864d74dcdd244f1703 273 Pfam PF07920 Protein of unknown function (DUF1684) 126 264 2.0E-43 T 17-03-2017 IPR012467 Protein of unknown function DUF1684 SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 Gene3D G3DSA:3.40.50.620 145 282 2.0E-17 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 Gene3D G3DSA:3.40.50.620 1 136 4.5E-24 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 Pfam PF00582 Universal stress protein family 1 136 1.2E-19 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 Pfam PF00582 Universal stress protein family 158 282 2.1E-10 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 SUPERFAMILY SSF52402 5 138 1.67E-21 T 17-03-2017 SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 SUPERFAMILY SSF52402 147 283 1.34E-15 T 17-03-2017 SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 PRINTS PR01438 Universal stress protein signature 96 108 2.1E-8 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 PRINTS PR01438 Universal stress protein signature 114 136 2.1E-8 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43430 1f95dca4f719a8a50601a5b9bea57f5b 284 PRINTS PR01438 Universal stress protein signature 2 20 2.1E-8 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 PIRSF PIRSF000538 17 495 3.0E-105 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 19 246 3.3E-43 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 SUPERFAMILY SSF53067 19 249 3.52E-57 T 17-03-2017 SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 SUPERFAMILY SSF53067 250 489 6.47E-55 T 17-03-2017 SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 Gene3D G3DSA:3.30.420.40 19 246 4.5E-58 T 17-03-2017 SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 Gene3D G3DSA:3.30.420.40 251 487 1.0E-66 T 17-03-2017 SHXM_RS44945 2c37ba96f6aa5dd1d91a3ea3a1ad17b0 498 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 256 441 4.7E-42 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 SUPERFAMILY SSF49373 906 970 4.97E-7 T 17-03-2017 IPR008964 Invasin/intimin cell-adhesion fragments SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Gene3D G3DSA:2.60.40.920 687 767 3.6E-4 T 17-03-2017 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Gene3D G3DSA:2.60.40.920 906 966 2.9E-7 T 17-03-2017 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 502 589 2.8E-16 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 793 882 9.0E-20 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 10 104 3.4E-12 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 696 785 8.4E-16 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 405 493 3.7E-16 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 212 299 2.8E-14 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 114 202 3.0E-20 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 599 687 1.7E-15 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS21240 db52dad537ae6cc2ba8845d2ed330a7a 993 Pfam PF16640 Bacterial Ig-like domain (group 3) 309 396 1.6E-15 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 Pfam PF02838 Glycosyl hydrolase family 20, domain 2 85 200 7.3E-13 T 17-03-2017 IPR015882 Beta-hexosaminidase, bacteial type, N-terminal KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 Gene3D G3DSA:3.30.379.10 74 190 3.6E-16 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 Gene3D G3DSA:3.20.20.80 191 554 1.4E-71 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 Pfam PF00728 Glycosyl hydrolase family 20, catalytic domain 207 536 3.7E-40 T 17-03-2017 IPR015883 Glycoside hydrolase family 20, catalytic domain GO:0004553|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 SUPERFAMILY SSF51445 206 550 1.14E-73 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 PRINTS PR00738 Glycosyl hydrolase family 20 signature 198 215 1.4E-15 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 PRINTS PR00738 Glycosyl hydrolase family 20 signature 275 292 1.4E-15 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 PRINTS PR00738 Glycosyl hydrolase family 20 signature 166 186 1.4E-15 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 PRINTS PR00738 Glycosyl hydrolase family 20 signature 499 515 1.4E-15 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 PRINTS PR00738 Glycosyl hydrolase family 20 signature 339 352 1.4E-15 T 17-03-2017 IPR025705 Beta-hexosaminidase GO:0004563|GO:0005975 KEGG: 00511+3.2.1.52|KEGG: 00513+3.2.1.52|KEGG: 00520+3.2.1.52|KEGG: 00531+3.2.1.52|KEGG: 00603+3.2.1.52|KEGG: 00604+3.2.1.52|MetaCyc: PWY-6902|Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS25095 fcafe2718af16ed1853cc59ec653274a 556 SUPERFAMILY SSF55545 79 202 5.89E-15 T 17-03-2017 IPR029018 Chitobiase/beta-hexosaminidase domain 2-like Reactome: R-HSA-1660662|Reactome: R-HSA-2022857|Reactome: R-HSA-2024101|Reactome: R-HSA-2160916 SHXM_RS20210 54136c7f31a8a7e993d3b61246f05bdc 397 Pfam PF04332 Protein of unknown function (DUF475) 44 380 1.2E-132 T 17-03-2017 IPR007427 Protein of unknown function DUF475 SHXM_RS11885 5b2ab6081639fc05b2a5ca5f519fc603 300 Pfam PF00483 Nucleotidyl transferase 3 234 1.9E-63 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS11885 5b2ab6081639fc05b2a5ca5f519fc603 300 Gene3D G3DSA:3.90.550.10 1 262 5.7E-62 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS11885 5b2ab6081639fc05b2a5ca5f519fc603 300 TIGRFAM TIGR01207 rmlA: glucose-1-phosphate thymidylyltransferase 2 285 9.7E-139 T 17-03-2017 IPR005907 Glucose-1-phosphate thymidylyltransferase, short form GO:0008879|GO:0045226 KEGG: 00521+2.7.7.24|KEGG: 00523+2.7.7.24|MetaCyc: PWY-3221|MetaCyc: PWY-6808|MetaCyc: PWY-6942|MetaCyc: PWY-6953|MetaCyc: PWY-6973|MetaCyc: PWY-6974|MetaCyc: PWY-6976|MetaCyc: PWY-7104|MetaCyc: PWY-7301|MetaCyc: PWY-7312|MetaCyc: PWY-7315|MetaCyc: PWY-7316|MetaCyc: PWY-7318|MetaCyc: PWY-7413|MetaCyc: PWY-7414|MetaCyc: PWY-7440|MetaCyc: PWY-7657|MetaCyc: PWY-7688 SHXM_RS11885 5b2ab6081639fc05b2a5ca5f519fc603 300 SUPERFAMILY SSF53448 1 286 2.7E-80 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS23295 e8c8eb411bd204efd1b3848841f1a300 158 Pfam PF03928 Haem-degrading 23 151 7.1E-32 T 17-03-2017 IPR005624 Haem-degrading SHXM_RS23295 e8c8eb411bd204efd1b3848841f1a300 158 PIRSF PIRSF008757 1 158 1.2E-59 T 17-03-2017 IPR010371 Uncharacterised protein family UPF0303 SHXM_RS23295 e8c8eb411bd204efd1b3848841f1a300 158 SUPERFAMILY SSF143744 15 153 3.79E-27 T 17-03-2017 SHXM_RS23295 e8c8eb411bd204efd1b3848841f1a300 158 Hamap MF_00761 UPF0303 protein . 1 156 33.206 T 17-03-2017 IPR010371 Uncharacterised protein family UPF0303 SHXM_RS15945 09917a74b704a5f9fb4bd50d11bc5ca9 321 PIRSF PIRSF017269 8 277 4.4E-85 T 17-03-2017 IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 GO:0016429|GO:0030488|GO:0031515 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829 SHXM_RS15945 09917a74b704a5f9fb4bd50d11bc5ca9 321 Gene3D G3DSA:3.10.330.20 2 75 2.4E-32 T 17-03-2017 SHXM_RS15945 09917a74b704a5f9fb4bd50d11bc5ca9 321 Gene3D G3DSA:3.40.50.150 77 283 1.9E-65 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS15945 09917a74b704a5f9fb4bd50d11bc5ca9 321 SUPERFAMILY SSF53335 13 266 1.31E-71 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS15945 09917a74b704a5f9fb4bd50d11bc5ca9 321 Pfam PF08704 tRNA methyltransferase complex GCD14 subunit 80 244 5.1E-22 T 17-03-2017 IPR014816 tRNA (1-methyladenosine) methyltransferase catalytic subunit Gcd14 GO:0016429|GO:0030488|GO:0031515 KEGG: 00340+2.1.1.22|MetaCyc: PWY-6829 SHXM_RS15945 09917a74b704a5f9fb4bd50d11bc5ca9 321 Pfam PF14801 tRNA methyltransferase complex GCD14 subunit N-term 11 61 2.6E-28 T 17-03-2017 SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 ProSitePatterns PS00168 Tryptophan synthase beta chain pyridoxal-phosphate attachment site. 93 107 - T 17-03-2017 IPR006653 Tryptophan synthase, beta chain, conserved site GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 PIRSF PIRSF001413 8 408 3.0E-160 T 17-03-2017 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 Hamap MF_00133 Tryptophan synthase beta chain [trpB]. 14 403 51.721 T 17-03-2017 IPR023026 Tryptophan synthase beta chain/beta chain-like GO:0000162|GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 SUPERFAMILY SSF53686 15 402 4.32E-146 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 TIGRFAM TIGR00263 trpB: tryptophan synthase, beta subunit 19 401 1.5E-183 T 17-03-2017 IPR006654 Tryptophan synthase, beta chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 Gene3D G3DSA:3.40.50.1100 111 189 1.1E-22 T 17-03-2017 SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 64 390 4.0E-51 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS18310 674ba3c482e2f1dcd66d48fc8dc177c8 415 Gene3D G3DSA:3.40.50.1100 190 404 1.4E-97 T 17-03-2017 SHXM_RS13110 7b1bdc4507ebddff45a0c3d5be8c4a19 382 SMART SM00331 124 361 5.9E-25 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS13110 7b1bdc4507ebddff45a0c3d5be8c4a19 382 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 155 362 3.2E-33 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS00295 ab145a59549c28d642fed690158f25cc 82 Pfam PF03995 Peptidase inhibitor family I36 30 66 7.4E-7 T 17-03-2017 SHXM_RS43370 6a17414c60af15851f416fcc4483583e 473 ProSitePatterns PS00217 Sugar transport proteins signature 2. 132 157 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS43370 6a17414c60af15851f416fcc4483583e 473 Gene3D G3DSA:1.20.1250.20 20 227 6.8E-23 T 17-03-2017 SHXM_RS43370 6a17414c60af15851f416fcc4483583e 473 Gene3D G3DSA:1.20.1250.20 255 443 4.3E-22 T 17-03-2017 SHXM_RS43370 6a17414c60af15851f416fcc4483583e 473 SUPERFAMILY SSF103473 5 446 9.16E-66 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS43370 6a17414c60af15851f416fcc4483583e 473 Pfam PF00083 Sugar (and other) transporter 24 447 7.2E-35 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS32405 73db3a3e9b4c5a78e2c09faf1b7e8f81 281 Gene3D G3DSA:3.40.50.1580 5 272 1.4E-83 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS32405 73db3a3e9b4c5a78e2c09faf1b7e8f81 281 Hamap MF_01963 S-methyl-5'-thioadenosine phosphorylase [mtnP]. 8 276 41.122 T 17-03-2017 IPR010044 Methylthioadenosine phosphorylase (MTAP) GO:0017061 Reactome: R-HSA-1237112 SHXM_RS32405 73db3a3e9b4c5a78e2c09faf1b7e8f81 281 SUPERFAMILY SSF53167 8 273 5.7E-82 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS32405 73db3a3e9b4c5a78e2c09faf1b7e8f81 281 Pfam PF01048 Phosphorylase superfamily 9 251 1.4E-40 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS32405 73db3a3e9b4c5a78e2c09faf1b7e8f81 281 TIGRFAM TIGR01694 MTAP: methylthioadenosine phosphorylase 10 256 2.6E-88 T 17-03-2017 IPR010044 Methylthioadenosine phosphorylase (MTAP) GO:0017061 Reactome: R-HSA-1237112 SHXM_RS10640 f826d6928692ab37e327b69c020c57a9 122 SUPERFAMILY SSF54427 3 107 1.24E-5 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS48510 c28d766361469d534fa9f1ebe59a74bb 351 SUPERFAMILY SSF51556 8 46 9.53E-76 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS48510 c28d766361469d534fa9f1ebe59a74bb 351 SUPERFAMILY SSF51556 73 346 9.53E-76 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS48510 c28d766361469d534fa9f1ebe59a74bb 351 ProSitePatterns PS01322 Phosphotriesterase family signature 1. 22 30 - T 17-03-2017 IPR017947 Aryldialkylphosphatase, zinc-binding site GO:0008270|GO:0009056|GO:0016788 SHXM_RS48510 c28d766361469d534fa9f1ebe59a74bb 351 Gene3D G3DSA:3.20.20.140 8 346 2.8E-103 T 17-03-2017 SHXM_RS48510 c28d766361469d534fa9f1ebe59a74bb 351 Pfam PF02126 Phosphotriesterase family 20 346 3.3E-47 T 17-03-2017 IPR001559 Phosphotriesterase GO:0008270|GO:0009056 SHXM_RS38470 f0bc031e25aa7e0d4641ef531bafa75f 467 Gene3D G3DSA:2.130.10.10 213 240 1.9E-6 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS38470 f0bc031e25aa7e0d4641ef531bafa75f 467 Gene3D G3DSA:2.130.10.10 290 454 1.9E-6 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS38470 f0bc031e25aa7e0d4641ef531bafa75f 467 SUPERFAMILY SSF63829 333 458 4.64E-9 T 17-03-2017 SHXM_RS38470 f0bc031e25aa7e0d4641ef531bafa75f 467 SUPERFAMILY SSF63829 220 276 4.64E-9 T 17-03-2017 SHXM_RS38470 f0bc031e25aa7e0d4641ef531bafa75f 467 Pfam PF05787 Bacterial protein of unknown function (DUF839) 50 149 8.7E-16 T 17-03-2017 IPR008557 Protein of unknown function DUF839 SHXM_RS38470 f0bc031e25aa7e0d4641ef531bafa75f 467 Pfam PF05787 Bacterial protein of unknown function (DUF839) 154 456 3.2E-72 T 17-03-2017 IPR008557 Protein of unknown function DUF839 SHXM_RS26075 228b434e6b7bdbe78f451058e42c06e9 252 Gene3D G3DSA:3.90.550.10 5 228 3.7E-26 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS26075 228b434e6b7bdbe78f451058e42c06e9 252 Pfam PF00535 Glycosyl transferase family 2 7 112 1.9E-8 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS26075 228b434e6b7bdbe78f451058e42c06e9 252 SUPERFAMILY SSF53448 4 218 7.31E-25 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS37360 f786a2c1d13279f95abfc00b808d8efa 390 Gene3D G3DSA:2.40.10.10 156 263 1.7E-6 T 17-03-2017 SHXM_RS37360 f786a2c1d13279f95abfc00b808d8efa 390 SUPERFAMILY SSF50494 135 363 2.18E-15 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SMART SM00710 317 339 2300.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SMART SM00710 126 156 2200.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SMART SM00710 213 234 2000.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SMART SM00710 182 207 3600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SMART SM00710 160 181 68.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SMART SM00710 260 286 3000.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 Gene3D G3DSA:2.160.20.10 51 356 4.7E-20 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS29680 6818fea518786884d0ae91760ccb1217 364 SUPERFAMILY SSF51126 49 353 6.77E-19 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 Pfam PF00797 N-acetyltransferase 30 271 8.3E-65 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 SUPERFAMILY SSF54001 6 274 3.92E-75 T 17-03-2017 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 PRINTS PR01543 Arylamine N-acetyltransferase signature 187 209 1.1E-11 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 PRINTS PR01543 Arylamine N-acetyltransferase signature 52 75 1.1E-11 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 PRINTS PR01543 Arylamine N-acetyltransferase signature 28 51 1.1E-11 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 PRINTS PR01543 Arylamine N-acetyltransferase signature 76 98 1.1E-11 T 17-03-2017 IPR001447 Arylamine N-acetyltransferase GO:0008152|GO:0016407 KEGG: 00232+2.3.1.5|KEGG: 00633+2.3.1.5|KEGG: 00983+2.3.1.5|Reactome: R-HSA-156582 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 Gene3D G3DSA:3.30.2140.10 199 274 3.7E-50 T 17-03-2017 SHXM_RS31500 81c2d0e9a9cd400520f8100b761fa130 278 Gene3D G3DSA:3.30.2140.10 6 92 3.7E-50 T 17-03-2017 SHXM_RS27635 bd81075707eede05c6d7360c8c9e8c93 172 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 52 98 9.5E-18 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS27635 bd81075707eede05c6d7360c8c9e8c93 172 Pfam PF02627 Carboxymuconolactone decarboxylase family 36 119 1.2E-16 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS27635 bd81075707eede05c6d7360c8c9e8c93 172 Gene3D G3DSA:1.20.1290.10 29 169 7.2E-48 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS27635 bd81075707eede05c6d7360c8c9e8c93 172 SUPERFAMILY SSF69118 30 169 6.53E-40 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS06085 f3336944fa26e115b5431d019596b8da 435 Gene3D G3DSA:1.10.10.10 339 394 5.9E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS06085 f3336944fa26e115b5431d019596b8da 435 Pfam PF01590 GAF domain 113 218 5.2E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS38450 3d899c0fa6363adbc28ba0ce75156ac3 227 Pfam PF01981 Peptidyl-tRNA hydrolase PTH2 143 223 1.6E-7 T 17-03-2017 IPR002833 Peptidyl-tRNA hydrolase, PTH2 GO:0004045 MetaCyc: PWY-6308 SHXM_RS38450 3d899c0fa6363adbc28ba0ce75156ac3 227 SUPERFAMILY SSF102462 136 224 6.63E-19 T 17-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 SHXM_RS38450 3d899c0fa6363adbc28ba0ce75156ac3 227 Gene3D G3DSA:3.40.1490.10 136 223 9.7E-17 T 17-03-2017 IPR023476 Peptidyl-tRNA hydrolase II domain MetaCyc: PWY-6308 SHXM_RS16295 6911150767afd838d83b2861e5a62db2 244 Pfam PF00174 Oxidoreductase molybdopterin binding domain 75 221 8.0E-37 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS16295 6911150767afd838d83b2861e5a62db2 244 Gene3D G3DSA:3.90.420.10 73 230 6.4E-49 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS16295 6911150767afd838d83b2861e5a62db2 244 SUPERFAMILY SSF56524 67 235 1.96E-51 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS06675 cf656dbe716ea55e5ffb5061c0607390 529 ProSitePatterns PS00455 Putative AMP-binding domain signature. 177 188 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS06675 cf656dbe716ea55e5ffb5061c0607390 529 Pfam PF00501 AMP-binding enzyme 18 427 3.2E-46 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS06675 cf656dbe716ea55e5ffb5061c0607390 529 Gene3D G3DSA:2.30.38.10 347 421 1.1E-12 T 17-03-2017 SHXM_RS06675 cf656dbe716ea55e5ffb5061c0607390 529 Gene3D G3DSA:3.40.50.980 184 335 1.3E-11 T 17-03-2017 SHXM_RS06675 cf656dbe716ea55e5ffb5061c0607390 529 SUPERFAMILY SSF56801 17 515 7.72E-67 T 17-03-2017 SHXM_RS06675 cf656dbe716ea55e5ffb5061c0607390 529 Gene3D G3DSA:3.40.50.980 32 183 4.0E-18 T 17-03-2017 SHXM_RS36820 6b9cd0fb282a1021b0e8600c0c8dfb4e 486 Pfam PF00171 Aldehyde dehydrogenase family 21 476 4.5E-132 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36820 6b9cd0fb282a1021b0e8600c0c8dfb4e 486 SUPERFAMILY SSF53720 9 481 1.57E-129 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS36820 6b9cd0fb282a1021b0e8600c0c8dfb4e 486 Gene3D G3DSA:3.40.605.10 9 282 6.0E-71 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36820 6b9cd0fb282a1021b0e8600c0c8dfb4e 486 Gene3D G3DSA:3.40.309.10 283 455 5.0E-55 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS00935 a978e9a1e2862069053da06b34772fc6 339 SUPERFAMILY SSF51004 10 328 7.32E-37 T 17-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SHXM_RS00935 a978e9a1e2862069053da06b34772fc6 339 Gene3D G3DSA:2.130.10.10 13 330 2.1E-37 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 Gene3D G3DSA:1.10.10.10 18 89 4.7E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 SMART SM00346 19 108 7.4E-24 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 Gene3D G3DSA:3.30.450.40 92 263 1.3E-53 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 SUPERFAMILY SSF46785 19 88 1.59E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 SUPERFAMILY SSF55781 76 263 1.18E-48 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 Pfam PF01614 Bacterial transcriptional regulator 137 259 2.3E-31 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS43770 279e089b3cbe52783c898ac0a7f2989a 265 Pfam PF09339 IclR helix-turn-helix domain 21 70 3.9E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 ProSitePatterns PS00356 LacI-type HTH domain signature. 8 26 - T 17-03-2017 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 Pfam PF00356 Bacterial regulatory proteins, lacI family 7 52 3.4E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 SUPERFAMILY SSF53822 94 349 1.99E-61 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 SMART SM00354 5 75 5.5E-22 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 Gene3D G3DSA:3.40.50.2300 58 196 1.6E-24 T 17-03-2017 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 Gene3D G3DSA:1.10.260.40 6 57 1.2E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 Gene3D G3DSA:3.40.50.2300 197 324 5.0E-47 T 17-03-2017 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 SUPERFAMILY SSF47413 5 63 1.13E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 Pfam PF13377 Periplasmic binding protein-like domain 191 349 3.7E-37 T 17-03-2017 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 7 17 1.4E-6 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS06920 4e54321f642a3b4d725dac2f9d3f3279 350 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 17 27 1.4E-6 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 Gene3D G3DSA:3.30.450.20 105 212 1.5E-14 T 17-03-2017 SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 SUPERFAMILY SSF141868 407 655 3.14E-83 T 17-03-2017 IPR001633 EAL domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 SMART SM00091 103 169 0.0014 T 17-03-2017 IPR000014 PAS domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 TIGRFAM TIGR00229 sensory_box: PAS domain S-box protein 105 220 1.0E-11 T 17-03-2017 IPR000014 PAS domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 Pfam PF00563 EAL domain 407 646 1.5E-67 T 17-03-2017 IPR001633 EAL domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 SUPERFAMILY SSF55785 105 202 6.11E-13 T 17-03-2017 IPR000014 PAS domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 SUPERFAMILY SSF55073 231 392 1.26E-40 T 17-03-2017 IPR029787 Nucleotide cyclase SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 Gene3D G3DSA:3.30.70.270 226 395 3.4E-50 T 17-03-2017 SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 Gene3D G3DSA:3.20.20.450 404 656 9.7E-106 T 17-03-2017 IPR001633 EAL domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 SMART SM00267 214 390 4.5E-49 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 SMART SM00052 400 651 1.5E-108 T 17-03-2017 IPR001633 EAL domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 TIGRFAM TIGR00254 GGDEF: diguanylate cyclase (GGDEF) domain 222 388 6.2E-32 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS22935 9600915268fa4d1fc0ba5d19c2837efa 662 Pfam PF00990 Diguanylate cyclase, GGDEF domain 226 385 4.0E-40 T 17-03-2017 IPR000160 GGDEF domain SHXM_RS41320 1f1ebd0795136fb7ed8645a41580c582 268 Pfam PF03746 LamB/YcsF family 7 244 1.9E-75 T 17-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SHXM_RS41320 1f1ebd0795136fb7ed8645a41580c582 268 SUPERFAMILY SSF88713 7 256 6.67E-73 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS08340 56a66cbf79e6b6092ece96bae46f0af0 202 SUPERFAMILY SSF55874 96 198 1.2E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08340 56a66cbf79e6b6092ece96bae46f0af0 202 Gene3D G3DSA:3.30.565.10 103 199 1.0E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08340 56a66cbf79e6b6092ece96bae46f0af0 202 Pfam PF13581 Histidine kinase-like ATPase domain 75 178 4.0E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42425 097ae470c30e209a7d2a1c1358dad8c2 254 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 73 247 1.4E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42425 097ae470c30e209a7d2a1c1358dad8c2 254 Gene3D G3DSA:1.10.3720.10 2 252 1.6E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42425 097ae470c30e209a7d2a1c1358dad8c2 254 SUPERFAMILY SSF161098 5 243 7.85E-45 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23595 edd5c66b884c589d91f0fe82401a8a62 356 Pfam PF03601 Conserved hypothetical protein 698 27 336 1.9E-63 T 17-03-2017 IPR018383 Uncharacterised protein family UPF0324, prokaryote GO:0016021 SHXM_RS33605 7569e771d81e8119e178a2050f8dfc85 233 SUPERFAMILY SSF159234 41 210 3.53E-45 T 17-03-2017 SHXM_RS33605 7569e771d81e8119e178a2050f8dfc85 233 Pfam PF04167 Protein of unknown function (DUF402) 98 162 2.9E-15 T 17-03-2017 IPR007295 Domain of unknown function DUF402 SHXM_RS33605 7569e771d81e8119e178a2050f8dfc85 233 Gene3D G3DSA:2.40.380.10 16 208 4.8E-75 T 17-03-2017 IPR007295 Domain of unknown function DUF402 SHXM_RS20080 4ceac590d765c40b8a94ca914a0fcd4a 158 ProSitePatterns PS01332 Rrf2-type HTH domain signature. 45 63 - T 17-03-2017 IPR030489 Transcription regulator Rrf2-type, conserved site SHXM_RS20080 4ceac590d765c40b8a94ca914a0fcd4a 158 Pfam PF02082 Transcriptional regulator 2 79 4.2E-22 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS20080 4ceac590d765c40b8a94ca914a0fcd4a 158 Gene3D G3DSA:1.10.10.10 1 139 1.3E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20080 4ceac590d765c40b8a94ca914a0fcd4a 158 SUPERFAMILY SSF46785 5 133 5.91E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20080 4ceac590d765c40b8a94ca914a0fcd4a 158 TIGRFAM TIGR00738 rrf2_super: Rrf2 family protein 5 134 1.8E-27 T 17-03-2017 IPR000944 Transcription regulator Rrf2-type SHXM_RS30480 50f73d6c4892970e67cbe58a4890c413 192 SUPERFAMILY SSF109604 7 177 2.07E-30 T 17-03-2017 SHXM_RS30480 50f73d6c4892970e67cbe58a4890c413 192 Gene3D G3DSA:1.10.3210.10 5 183 4.0E-43 T 17-03-2017 IPR006674 HD domain SHXM_RS30480 50f73d6c4892970e67cbe58a4890c413 192 Pfam PF13023 HD domain 16 166 2.5E-24 T 17-03-2017 IPR006674 HD domain SHXM_RS23030 1182a264560734e4a8f8589950e18262 303 SUPERFAMILY SSF53474 7 302 1.06E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23030 1182a264560734e4a8f8589950e18262 303 Pfam PF12146 Serine aminopeptidase, S33 72 189 1.2E-12 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS23030 1182a264560734e4a8f8589950e18262 303 Gene3D G3DSA:3.40.50.1820 60 302 1.1E-34 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS44745 0502820522e68a3726653a1e229da5e5 1168 SUPERFAMILY SSF56300 797 1010 3.32E-24 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS44745 0502820522e68a3726653a1e229da5e5 1168 Pfam PF00149 Calcineurin-like phosphoesterase 799 957 3.4E-10 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS44745 0502820522e68a3726653a1e229da5e5 1168 Pfam PF09992 Phosphodiester glycosidase 248 422 9.8E-31 T 17-03-2017 IPR018711 Phosphodiester glycosidase SHXM_RS44745 0502820522e68a3726653a1e229da5e5 1168 Gene3D G3DSA:3.60.21.10 797 1026 1.9E-18 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS24090 be694cc6842ebe2d77bc6fac168604b9 394 Pfam PF06224 Winged helix DNA-binding domain 47 369 3.4E-66 T 17-03-2017 IPR009351 Protein of unknown function DUF1006 SHXM_RS39810 fc33113d845b629cd468608db6c0db2b 304 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 205 1.6E-7 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS39810 fc33113d845b629cd468608db6c0db2b 304 Gene3D G3DSA:3.40.50.720 8 297 4.5E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39810 fc33113d845b629cd468608db6c0db2b 304 SUPERFAMILY SSF51735 5 297 1.15E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31775 8f1d0845518e58f7f66693fb2542a548 261 SUPERFAMILY SSF54593 135 254 1.61E-10 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS31775 8f1d0845518e58f7f66693fb2542a548 261 Gene3D G3DSA:3.10.180.10 137 257 2.3E-25 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS31775 8f1d0845518e58f7f66693fb2542a548 261 Gene3D G3DSA:3.10.180.10 9 123 7.6E-31 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS31775 8f1d0845518e58f7f66693fb2542a548 261 SUPERFAMILY SSF54593 15 164 2.2E-16 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS32270 c2d004ce087feb44d6bb9ad890d26d3f 435 Gene3D G3DSA:3.50.50.60 93 229 1.3E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS32270 c2d004ce087feb44d6bb9ad890d26d3f 435 Pfam PF13434 L-lysine 6-monooxygenase (NADPH-requiring) 5 343 3.8E-126 T 17-03-2017 IPR025700 L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase SHXM_RS32270 c2d004ce087feb44d6bb9ad890d26d3f 435 SUPERFAMILY SSF51905 4 259 2.45E-18 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 SUPERFAMILY SSF53167 18 274 2.75E-80 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 TIGRFAM TIGR01698 PUNP: purine nucleotide phosphorylase 35 270 5.1E-103 T 17-03-2017 IPR011269 Putative purine nucleotide phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 Pfam PF01048 Phosphorylase superfamily 36 271 1.9E-41 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 TIGRFAM TIGR01697 PNPH-PUNA-XAPA: inosine/guanosine/xanthosine phosphorylase family 35 271 7.7E-76 T 17-03-2017 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-74217|Reactome: R-HSA-74259 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 Gene3D G3DSA:3.40.50.1580 16 273 8.6E-90 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 PIRSF PIRSF000477 8 274 3.9E-89 T 17-03-2017 IPR011268 Purine nucleoside phosphorylase GO:0004731|GO:0006139 KEGG: 00230+2.4.2.1|KEGG: 00240+2.4.2.1|KEGG: 00760+2.4.2.1|MetaCyc: PWY-4202|MetaCyc: PWY-5695|MetaCyc: PWY-6608|MetaCyc: PWY-6609|MetaCyc: PWY-6611|MetaCyc: PWY-6620|MetaCyc: PWY-6627|MetaCyc: PWY-6644|MetaCyc: PWY-7179|MetaCyc: PWY-7179-1|Reactome: R-HSA-74217|Reactome: R-HSA-74259 SHXM_RS24730 bdb5ee539ed2b83d80d46fac5b00f3ca 274 ProSitePatterns PS01240 Purine and other phosphorylases family 2 signature. 89 130 - T 17-03-2017 IPR018099 Purine phosphorylase, family 2, conserved site GO:0016763 SHXM_RS13615 0a644ab8235b2742da9c87cfbebe353a 515 Pfam PF13520 Amino acid permease 40 482 6.4E-40 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS13615 0a644ab8235b2742da9c87cfbebe353a 515 PIRSF PIRSF006060 15 514 3.4E-60 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS12635 ad6ee283211d8ad6e03066a5df5f2214 162 Gene3D G3DSA:3.30.530.20 5 146 2.3E-17 T 17-03-2017 IPR023393 START-like domain SHXM_RS12635 ad6ee283211d8ad6e03066a5df5f2214 162 SUPERFAMILY SSF55961 7 145 2.75E-18 T 17-03-2017 SHXM_RS12635 ad6ee283211d8ad6e03066a5df5f2214 162 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 9 118 5.8E-9 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS10205 deb63eecab9ceeb9dc1e53d3eb0afc84 191 SMART SM00471 35 149 1.6E-6 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS10205 deb63eecab9ceeb9dc1e53d3eb0afc84 191 Gene3D G3DSA:1.10.3210.10 4 185 2.8E-42 T 17-03-2017 IPR006674 HD domain SHXM_RS10205 deb63eecab9ceeb9dc1e53d3eb0afc84 191 SUPERFAMILY SSF109604 10 161 3.14E-32 T 17-03-2017 SHXM_RS10205 deb63eecab9ceeb9dc1e53d3eb0afc84 191 Pfam PF13023 HD domain 18 159 3.0E-26 T 17-03-2017 IPR006674 HD domain SHXM_RS00430 6afb62a2b371046d85af1bd9ab7b6508 211 Gene3D G3DSA:1.10.10.10 141 197 7.2E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 SUPERFAMILY SSF161098 395 581 7.33E-32 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 Gene3D G3DSA:1.10.3720.10 396 589 1.6E-27 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 Gene3D G3DSA:1.10.3720.10 82 278 3.6E-32 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 108 271 1.5E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 419 585 5.5E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 SUPERFAMILY SSF161098 83 268 5.49E-34 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 TIGRFAM TIGR01097 PhnE: phosphonate ABC transporter, permease protein PhnE 343 591 2.4E-67 T 17-03-2017 IPR005769 ABC transporter, permease PhnE/PtxC GO:0005887|GO:0015604|GO:0015716 SHXM_RS49520 5e68999c789555c7af0bc4935a9ecacc 592 TIGRFAM TIGR01097 PhnE: phosphonate ABC transporter, permease protein PhnE 37 279 4.9E-71 T 17-03-2017 IPR005769 ABC transporter, permease PhnE/PtxC GO:0005887|GO:0015604|GO:0015716 SHXM_RS03655 d8db139ef71d939ab34d0f826200cdb6 316 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 21 304 3.9E-63 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS03655 d8db139ef71d939ab34d0f826200cdb6 316 Gene3D G3DSA:3.40.50.1100 72 312 2.2E-56 T 17-03-2017 SHXM_RS03655 d8db139ef71d939ab34d0f826200cdb6 316 SUPERFAMILY SSF53686 5 305 1.83E-67 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS38735 adc9e2175f9e9a0ca06c78842456c9a8 182 Gene3D G3DSA:3.40.50.300 7 182 2.1E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38735 adc9e2175f9e9a0ca06c78842456c9a8 182 SUPERFAMILY SSF52540 8 179 3.69E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38735 adc9e2175f9e9a0ca06c78842456c9a8 182 TIGRFAM TIGR00455 apsK: adenylyl-sulfate kinase 7 172 2.5E-57 T 17-03-2017 IPR002891 Adenylyl-sulfate kinase GO:0000103|GO:0004020|GO:0005524 KEGG: 00230+2.7.1.25|KEGG: 00920+2.7.1.25|MetaCyc: PWY-5340|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 SHXM_RS38735 adc9e2175f9e9a0ca06c78842456c9a8 182 Hamap MF_00065 Adenylyl-sulfate kinase [cysC]. 6 180 33.772 T 17-03-2017 IPR002891 Adenylyl-sulfate kinase GO:0000103|GO:0004020|GO:0005524 KEGG: 00230+2.7.1.25|KEGG: 00920+2.7.1.25|MetaCyc: PWY-5340|Reactome: R-HSA-174362|Reactome: R-HSA-2408550 SHXM_RS38735 adc9e2175f9e9a0ca06c78842456c9a8 182 Pfam PF01583 Adenylylsulphate kinase 8 164 2.4E-59 T 17-03-2017 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 Pfam PF13193 AMP-binding enzyme C-terminal domain 552 627 3.9E-6 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS43860 f7e291051f140d70a010717248b17278 679 TIGRFAM TIGR01217 ac_ac_CoA_syn: acetoacetate-CoA ligase 10 667 0.0 T 17-03-2017 IPR005914 Acetoacetyl-CoA synthase GO:0006629|GO:0030729 KEGG: 00280+6.2.1.16|KEGG: 00650+6.2.1.16|Reactome: R-HSA-77111 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 ProSitePatterns PS00455 Putative AMP-binding domain signature. 282 293 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS43860 f7e291051f140d70a010717248b17278 679 Gene3D G3DSA:3.40.50.980 117 287 3.3E-26 T 17-03-2017 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 Gene3D G3DSA:3.30.300.30 538 628 8.1E-13 T 17-03-2017 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 Gene3D G3DSA:3.40.50.980 288 441 6.6E-15 T 17-03-2017 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 Pfam PF00501 AMP-binding enzyme 118 539 1.1E-44 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 SUPERFAMILY SSF56801 51 659 5.49E-125 T 17-03-2017 SHXM_RS43860 f7e291051f140d70a010717248b17278 679 Pfam PF16177 Acetyl-coenzyme A synthetase N-terminus 52 108 5.4E-15 T 17-03-2017 IPR032387 Acetyl-coenzyme A synthetase, N-terminal domain KEGG: 00010+6.2.1.1|KEGG: 00620+6.2.1.1|KEGG: 00640+6.2.1.1|KEGG: 00680+6.2.1.1|KEGG: 00720+6.2.1.1|MetaCyc: PWY-6672|MetaCyc: PWY-7118 SHXM_RS33560 c1e2bd874c52f05c98c21abfb37bbf1e 174 SUPERFAMILY SSF46785 3 167 9.73E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33560 c1e2bd874c52f05c98c21abfb37bbf1e 174 Gene3D G3DSA:1.10.10.10 1 87 1.3E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33560 c1e2bd874c52f05c98c21abfb37bbf1e 174 Pfam PF03551 Transcriptional regulator PadR-like family 7 77 6.8E-15 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 SUPERFAMILY SSF103491 2 427 2.35E-127 T 17-03-2017 IPR023201 SecY subunit domain Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PIRSF PIRSF004557 1 437 5.0E-125 T 17-03-2017 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 ProSitePatterns PS00756 Protein secY signature 2. 176 193 - T 17-03-2017 IPR030659 SecY conserved site Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 Pfam PF00344 SecY translocase 73 420 1.0E-117 T 17-03-2017 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 TIGRFAM TIGR00967 3a0501s007: preprotein translocase, SecY subunit 15 432 1.2E-147 T 17-03-2017 IPR002208 SecY/SEC61-alpha family GO:0015031|GO:0016020 Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 Hamap MF_01465 Protein translocase subunit SecY [secY]. 5 436 29.493 T 17-03-2017 IPR026593 Protein translocase subunit SecY SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 Gene3D G3DSA:1.10.3370.10 2 437 6.0E-159 T 17-03-2017 IPR023201 SecY subunit domain Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 ProSitePatterns PS00755 Protein secY signature 1. 73 92 - T 17-03-2017 IPR030659 SecY conserved site Reactome: R-HSA-1236974|Reactome: R-HSA-1799339|Reactome: R-HSA-381038 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 274 293 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 113 136 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 183 206 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 316 338 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 371 389 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 157 182 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 72 92 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 18 36 1.3E-106 T 17-03-2017 SHXM_RS31270 0c2e8ac77a8f3ea7bfc73aefebe97ded 437 PRINTS PR00303 Preprotein translocase SecY subunit signature 405 423 1.3E-106 T 17-03-2017 SHXM_RS26955 948fd3bae88a1a3aa05efa1c677c9901 405 Gene3D G3DSA:3.40.1050.10 127 363 4.9E-77 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS26955 948fd3bae88a1a3aa05efa1c677c9901 405 SUPERFAMILY SSF53056 122 361 2.35E-48 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS26955 948fd3bae88a1a3aa05efa1c677c9901 405 Pfam PF00484 Carbonic anhydrase 164 347 1.2E-40 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS26955 948fd3bae88a1a3aa05efa1c677c9901 405 SMART SM00947 156 353 3.6E-54 T 17-03-2017 IPR001765 Carbonic anhydrase GO:0004089|GO:0008270 KEGG: 00910+4.2.1.1|MetaCyc: PWY-241|MetaCyc: PWY-6142|MetaCyc: PWY-7115|MetaCyc: PWY-7117 SHXM_RS34735 7a805350d13661b82095895c449afdd7 131 Gene3D G3DSA:1.20.120.400 15 130 4.3E-50 T 17-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 SHXM_RS34735 7a805350d13661b82095895c449afdd7 131 SUPERFAMILY SSF109770 15 130 4.45E-54 T 17-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 SHXM_RS34735 7a805350d13661b82095895c449afdd7 131 TIGRFAM TIGR02753 sodN: superoxide dismutase, Ni 1 130 5.9E-57 T 17-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 SHXM_RS34735 7a805350d13661b82095895c449afdd7 131 Pfam PF09055 Nickel-containing superoxide dismutase 11 129 3.9E-43 T 17-03-2017 IPR014123 Superoxide dismutase, Nickel-type GO:0004784|GO:0016151|GO:0016209 MetaCyc: PWY-6854 SHXM_RS03275 6058d846288d6431cff7cf32b39fc4fb 269 SUPERFAMILY SSF161098 63 245 1.27E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03275 6058d846288d6431cff7cf32b39fc4fb 269 Gene3D G3DSA:1.10.3720.10 61 257 5.7E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03275 6058d846288d6431cff7cf32b39fc4fb 269 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 86 256 2.5E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40175 bfe3a40a2c283cc1d2dcf8b6de7ce403 663 Gene3D G3DSA:1.20.1560.10 65 360 2.5E-11 T 17-03-2017 SHXM_RS40175 bfe3a40a2c283cc1d2dcf8b6de7ce403 663 SUPERFAMILY SSF52540 388 641 7.99E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40175 bfe3a40a2c283cc1d2dcf8b6de7ce403 663 SUPERFAMILY SSF90123 60 358 4.97E-19 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS40175 bfe3a40a2c283cc1d2dcf8b6de7ce403 663 Pfam PF00005 ABC transporter 411 570 6.0E-21 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS40175 bfe3a40a2c283cc1d2dcf8b6de7ce403 663 Gene3D G3DSA:3.40.50.300 394 636 1.0E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40175 bfe3a40a2c283cc1d2dcf8b6de7ce403 663 SMART SM00382 420 633 5.7E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 SUPERFAMILY SSF53822 63 339 2.72E-53 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 Pfam PF13377 Periplasmic binding protein-like domain 173 338 1.5E-31 T 17-03-2017 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 Gene3D G3DSA:3.40.50.2300 56 176 2.4E-31 T 17-03-2017 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 SUPERFAMILY SSF47413 3 61 3.44E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 Gene3D G3DSA:3.40.50.2300 177 316 2.0E-39 T 17-03-2017 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 Pfam PF00356 Bacterial regulatory proteins, lacI family 5 50 3.3E-20 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 ProSitePatterns PS00356 LacI-type HTH domain signature. 6 24 - T 17-03-2017 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 SMART SM00354 3 73 5.9E-30 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS01790 9ddb2037c36fc4310bd1b4dc2c53db1b 347 Gene3D G3DSA:1.10.260.40 4 55 7.1E-27 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS14680 f09de1622e9fd9b3763cbca1aa943164 239 Pfam PF13649 Methyltransferase domain 52 147 8.3E-10 T 17-03-2017 SHXM_RS14680 f09de1622e9fd9b3763cbca1aa943164 239 SUPERFAMILY SSF53335 8 160 4.18E-21 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14680 f09de1622e9fd9b3763cbca1aa943164 239 Gene3D G3DSA:3.40.50.150 8 207 4.1E-19 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14375 1f3dadbc067be9eeebcb4f70cbbf6273 348 PIRSF PIRSF026166 17 344 3.6E-111 T 17-03-2017 IPR016833 Putative sodium bile acid cotransporter SHXM_RS14375 1f3dadbc067be9eeebcb4f70cbbf6273 348 Pfam PF13593 SBF-like CPA transporter family (DUF4137) 23 328 1.6E-84 T 17-03-2017 IPR016833 Putative sodium bile acid cotransporter SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 Pfam PF02254 TrkA-N domain 3 118 9.7E-25 T 17-03-2017 IPR003148 Regulator of K+ conductance, N-terminal GO:0006813 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 PRINTS PR00335 TrkA potassium uptake protein signature 2 16 4.0E-7 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 PRINTS PR00335 TrkA potassium uptake protein signature 59 69 4.0E-7 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 PRINTS PR00335 TrkA potassium uptake protein signature 72 86 4.0E-7 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 PRINTS PR00335 TrkA potassium uptake protein signature 19 33 4.0E-7 T 17-03-2017 IPR006036 Potassium uptake protein TrkA GO:0005886|GO:0006813|GO:0015079 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 Gene3D G3DSA:3.40.50.720 1 132 7.9E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 Pfam PF02080 TrkA-C domain 149 216 4.3E-12 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 Gene3D G3DSA:3.30.70.1450 147 217 3.9E-12 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 SUPERFAMILY SSF116726 133 216 5.36E-14 T 17-03-2017 IPR006037 Regulator of K+ conductance, C-terminal GO:0006813|GO:0008324 SHXM_RS37665 acade9826b29720357cd980acfb15fdb 225 SUPERFAMILY SSF51735 1 145 1.38E-28 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11740 0f7526422f6252f243e260ef3cdcab54 156 SUPERFAMILY SSF46785 4 150 2.42E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11740 0f7526422f6252f243e260ef3cdcab54 156 SMART SM00347 32 135 7.6E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS11740 0f7526422f6252f243e260ef3cdcab54 156 Gene3D G3DSA:1.10.10.10 2 152 2.4E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11740 0f7526422f6252f243e260ef3cdcab54 156 Pfam PF12802 MarR family 38 98 9.8E-13 T 17-03-2017 SHXM_RS06275 d04a4498e5dea8884987515543292b97 215 Gene3D G3DSA:1.10.357.10 10 201 5.8E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS06275 d04a4498e5dea8884987515543292b97 215 SUPERFAMILY SSF46689 10 80 1.1E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS06275 d04a4498e5dea8884987515543292b97 215 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 66 1.9E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 Gene3D G3DSA:3.30.450.40 90 256 2.1E-27 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 SUPERFAMILY SSF55781 75 254 1.41E-26 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 SMART SM00346 21 107 1.3E-14 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 SUPERFAMILY SSF46785 21 88 1.65E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 Pfam PF01614 Bacterial transcriptional regulator 137 250 1.7E-8 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 Gene3D G3DSA:1.10.10.10 19 80 4.3E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27950 fb556dcbb5b784378ce3ca144c8da2ea 259 Pfam PF09339 IclR helix-turn-helix domain 21 69 1.1E-13 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS27625 6086d4798fc127a4fcce6306adc71dad 542 Gene3D G3DSA:3.30.450.40 49 116 3.0E-5 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27625 6086d4798fc127a4fcce6306adc71dad 542 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 342 541 9.3E-33 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS27625 6086d4798fc127a4fcce6306adc71dad 542 SMART SM00331 318 541 1.1E-14 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS14050 b634b3ee4a9255c3cd4037a1287a4a5e 329 Pfam PF00296 Luciferase-like monooxygenase 7 260 1.3E-39 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14050 b634b3ee4a9255c3cd4037a1287a4a5e 329 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 21 302 5.5E-57 T 17-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted SHXM_RS14050 b634b3ee4a9255c3cd4037a1287a4a5e 329 Gene3D G3DSA:3.20.20.30 1 329 1.6E-64 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14050 b634b3ee4a9255c3cd4037a1287a4a5e 329 SUPERFAMILY SSF51679 1 329 4.06E-60 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 Pfam PF00356 Bacterial regulatory proteins, lacI family 22 65 1.2E-15 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 Gene3D G3DSA:3.40.50.2300 71 191 1.2E-32 T 17-03-2017 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 SUPERFAMILY SSF47413 19 76 8.91E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 SUPERFAMILY SSF53822 78 343 2.36E-52 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 Gene3D G3DSA:3.40.50.2300 192 318 1.3E-37 T 17-03-2017 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 SMART SM00354 18 88 1.6E-22 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 Pfam PF13377 Periplasmic binding protein-like domain 185 343 1.6E-27 T 17-03-2017 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 Gene3D G3DSA:1.10.260.40 21 70 5.1E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50065 b65ede51664fa65e6c83a89acb1984e0 344 ProSitePatterns PS00356 LacI-type HTH domain signature. 21 39 - T 17-03-2017 SHXM_RS44000 79d6411b30ec3faa77e606f947349893 218 SUPERFAMILY SSF46785 58 150 9.47E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44000 79d6411b30ec3faa77e606f947349893 218 Pfam PF03551 Transcriptional regulator PadR-like family 71 139 3.6E-21 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS44000 79d6411b30ec3faa77e606f947349893 218 Gene3D G3DSA:1.10.10.10 60 145 1.3E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02440 84a19bc7f8ea8f7860b1439491a61aba 542 SUPERFAMILY SSF53300 362 512 4.2E-12 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS02440 84a19bc7f8ea8f7860b1439491a61aba 542 Pfam PF13519 von Willebrand factor type A domain 363 476 7.8E-9 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS02440 84a19bc7f8ea8f7860b1439491a61aba 542 SMART SM00327 359 542 5.8E-9 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS14655 3c8781c6e729fe53ab4ac750dbac6419 184 Pfam PF13302 Acetyltransferase (GNAT) domain 12 149 1.8E-20 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS14655 3c8781c6e729fe53ab4ac750dbac6419 184 Gene3D G3DSA:3.40.630.30 7 173 8.3E-43 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS14655 3c8781c6e729fe53ab4ac750dbac6419 184 SUPERFAMILY SSF55729 7 173 6.26E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS00460 3c8e108fa6ceaee10a7ac5a282e83c68 400 Pfam PF01548 Transposase 11 166 2.0E-43 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS00460 3c8e108fa6ceaee10a7ac5a282e83c68 400 Pfam PF02371 Transposase IS116/IS110/IS902 family 274 357 4.2E-23 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS14020 f63f925dfb4ad9a10f639938d9344c41 502 Pfam PF07730 Histidine kinase 212 278 6.2E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS14020 f63f925dfb4ad9a10f639938d9344c41 502 SUPERFAMILY SSF55874 299 415 5.62E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 SUPERFAMILY SSF55729 146 291 7.42E-8 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 Pfam PF00155 Aminotransferase class I and II 374 651 2.5E-34 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 SUPERFAMILY SSF53383 335 654 6.26E-56 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 Pfam PF13480 Acetyltransferase (GNAT) domain 158 274 1.0E-6 T 17-03-2017 SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 Gene3D G3DSA:3.40.640.10 347 546 5.4E-46 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 515 524 - T 17-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SHXM_RS02585 5722fa9a3f5d7eeaa66948ddda62c325 655 Gene3D G3DSA:3.90.1150.10 547 653 5.4E-24 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS36305 393bf7b78ecdebecfd6fce5ffc0979bf 263 Pfam PF10370 Domain of unknown function (DUF2437) 2 57 1.5E-14 T 17-03-2017 IPR018833 Domain of unknown function DUF2437 SHXM_RS36305 393bf7b78ecdebecfd6fce5ffc0979bf 263 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 62 259 1.4E-68 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS36305 393bf7b78ecdebecfd6fce5ffc0979bf 263 Gene3D G3DSA:3.90.850.10 53 261 4.8E-90 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS36305 393bf7b78ecdebecfd6fce5ffc0979bf 263 SUPERFAMILY SSF56529 54 260 2.49E-78 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS42490 b5f80f9f8b72e269b1a6b60cfe52218d 243 Gene3D G3DSA:3.40.50.1820 20 242 7.3E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42490 b5f80f9f8b72e269b1a6b60cfe52218d 243 SUPERFAMILY SSF53474 20 86 2.99E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42490 b5f80f9f8b72e269b1a6b60cfe52218d 243 SUPERFAMILY SSF53474 119 243 2.99E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS44865 b153bb2c45c0632cb57f8fb66b1e37d5 659 Pfam PF00155 Aminotransferase class I and II 56 357 8.2E-25 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS44865 b153bb2c45c0632cb57f8fb66b1e37d5 659 Gene3D G3DSA:3.40.640.10 42 258 1.2E-45 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS44865 b153bb2c45c0632cb57f8fb66b1e37d5 659 SUPERFAMILY SSF53383 22 363 5.33E-53 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS44865 b153bb2c45c0632cb57f8fb66b1e37d5 659 Gene3D G3DSA:3.90.1150.10 259 364 2.2E-22 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS26965 26a1a31a0966c71ea1be6655c31498a4 463 Pfam PF06965 Na+/H+ antiporter 1 24 396 1.7E-133 T 17-03-2017 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SHXM_RS26965 26a1a31a0966c71ea1be6655c31498a4 463 Hamap MF_01844 Na(+)/H(+) antiporter NhaA [nhaA]. 21 402 20.84 T 17-03-2017 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SHXM_RS26965 26a1a31a0966c71ea1be6655c31498a4 463 Gene3D G3DSA:1.20.1530.10 21 402 5.1E-135 T 17-03-2017 IPR023171 Na/H antiporter domain SHXM_RS26965 26a1a31a0966c71ea1be6655c31498a4 463 TIGRFAM TIGR00773 NhaA: Na+/H+ antiporter NhaA 26 392 3.1E-100 T 17-03-2017 IPR004670 Na+/H+ antiporter NhaA GO:0006814|GO:0006885|GO:0016021 SHXM_RS10415 dd34282325059a8cd71b6f0e3a7d27c9 243 Gene3D G3DSA:3.10.180.10 124 242 2.0E-23 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS10415 dd34282325059a8cd71b6f0e3a7d27c9 243 Gene3D G3DSA:3.10.180.10 2 109 5.1E-23 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS10415 dd34282325059a8cd71b6f0e3a7d27c9 243 SUPERFAMILY SSF54593 125 241 3.89E-17 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS10415 dd34282325059a8cd71b6f0e3a7d27c9 243 SUPERFAMILY SSF54593 1 148 8.94E-16 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS40930 7268626b0a4b5a43404203875fe8af39 379 SUPERFAMILY SSF50952 48 368 6.41E-29 T 17-03-2017 IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase GO:0003824 SHXM_RS40930 7268626b0a4b5a43404203875fe8af39 379 Pfam PF07995 Glucose / Sorbosone dehydrogenase 50 367 1.1E-44 T 17-03-2017 IPR012938 Glucose/Sorbosone dehydrogenase GO:0005975|GO:0016901|GO:0048038 SHXM_RS40930 7268626b0a4b5a43404203875fe8af39 379 Gene3D G3DSA:2.120.10.30 34 378 5.0E-98 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS41960 a389481e8259130a06587ce1cfa0a0c9 316 Pfam PF09362 Domain of unknown function (DUF1996) 83 291 8.2E-52 T 17-03-2017 IPR018535 Domain of unknown function DUF1996 SHXM_RS16230 8722ea1c1f09e3cf3e0ac5a3bbee39c7 218 Pfam PF00925 GTP cyclohydrolase II 18 184 4.3E-63 T 17-03-2017 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS16230 8722ea1c1f09e3cf3e0ac5a3bbee39c7 218 Hamap MF_00179 GTP cyclohydrolase-2 [ribA]. 15 210 38.921 T 17-03-2017 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS16230 8722ea1c1f09e3cf3e0ac5a3bbee39c7 218 TIGRFAM TIGR00505 ribA: GTP cyclohydrolase II 19 208 1.7E-65 T 17-03-2017 IPR000926 GTP cyclohydrolase II, RibA GO:0003935|GO:0009231 KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS16230 8722ea1c1f09e3cf3e0ac5a3bbee39c7 218 SUPERFAMILY SSF142695 17 186 9.42E-58 T 17-03-2017 IPR032677 GTP cyclohydrolase II KEGG: 00740+3.5.4.25|MetaCyc: PWY-6168|MetaCyc: PWY-7539 SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 54 70 9.9E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 40 54 9.9E-7 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 SUPERFAMILY SSF46785 12 84 2.77E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 80 1.6E-13 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 Gene3D G3DSA:3.40.1410.10 92 245 6.0E-31 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 SMART SM00345 21 80 2.9E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 Gene3D G3DSA:1.10.10.10 12 83 1.9E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 SMART SM00866 101 241 1.7E-17 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 SUPERFAMILY SSF64288 68 246 4.87E-34 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS16515 3f38f66bfc6ca92def7c416f8f42dafa 249 Pfam PF07702 UTRA domain 107 240 1.1E-25 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS26900 322d4a70183cda74e823b30f73469f11 903 TIGRFAM TIGR03816 tadE_like_DECH: helicase/secretion neighborhood TadE-like protein 6 109 8.9E-26 T 17-03-2017 IPR021202 Helicase/secretion neighbourhood TadE-like protein SHXM_RS26900 322d4a70183cda74e823b30f73469f11 903 Pfam PF13400 Putative Flp pilus-assembly TadE/G-like 8 54 7.1E-6 T 17-03-2017 IPR028087 Putative Flp pilus-assembly TadG-like, N-terminal SHXM_RS47240 c73184745bc13bfef5fc4a1965bb4836 308 SUPERFAMILY SSF161098 72 298 2.22E-67 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47240 c73184745bc13bfef5fc4a1965bb4836 308 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 122 296 6.3E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47240 c73184745bc13bfef5fc4a1965bb4836 308 Gene3D G3DSA:1.10.3720.10 77 305 7.7E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS28900 29194fc93e1ee9fa8a05af9e8ce85b33 732 Gene3D G3DSA:1.20.1640.10 129 343 5.6E-25 T 17-03-2017 SHXM_RS28900 29194fc93e1ee9fa8a05af9e8ce85b33 732 Gene3D G3DSA:1.20.1640.10 509 710 6.0E-28 T 17-03-2017 SHXM_RS28900 29194fc93e1ee9fa8a05af9e8ce85b33 732 SUPERFAMILY SSF82866 114 337 1.06E-22 T 17-03-2017 SHXM_RS28900 29194fc93e1ee9fa8a05af9e8ce85b33 732 Pfam PF03176 MMPL family 67 375 1.6E-36 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS28900 29194fc93e1ee9fa8a05af9e8ce85b33 732 Pfam PF03176 MMPL family 407 710 2.7E-30 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS28900 29194fc93e1ee9fa8a05af9e8ce85b33 732 SUPERFAMILY SSF82866 488 708 5.36E-27 T 17-03-2017 SHXM_RS35290 bb548ea7060b5ac9629595308b6d980d 190 ProDom PD007457 TRANSFERASE ADENOSYLTRANSFERASE COBALAMIN ATP:COBIALAMIN ADENOSYLTRANSFERASE PDUO TYPE RELATED ACIDURIA YVQK 13 184 2.0E-70 T 17-03-2017 IPR029499 ATP:cob(I)alamin adenosyltransferase, PduO-type KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 SHXM_RS35290 bb548ea7060b5ac9629595308b6d980d 190 Gene3D G3DSA:1.20.1200.10 16 188 6.8E-54 T 17-03-2017 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 SHXM_RS35290 bb548ea7060b5ac9629595308b6d980d 190 TIGRFAM TIGR00636 PduO_Nterm: ATP:cob(I)alamin adenosyltransferase 8 182 5.4E-48 T 17-03-2017 IPR029499 ATP:cob(I)alamin adenosyltransferase, PduO-type KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 SHXM_RS35290 bb548ea7060b5ac9629595308b6d980d 190 SUPERFAMILY SSF89028 6 185 9.22E-53 T 17-03-2017 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 SHXM_RS35290 bb548ea7060b5ac9629595308b6d980d 190 Pfam PF01923 Cobalamin adenosyltransferase 7 174 5.3E-52 T 17-03-2017 IPR016030 Adenosylcobalamin biosynthesis, ATP:cob(I)alamin adenosyltransferase-like KEGG: 00860+2.5.1.17|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6268|MetaCyc: PWY-6269|Reactome: R-HSA-196741|Reactome: R-HSA-3359471 SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 Gene3D G3DSA:2.60.120.260 16 183 3.5E-57 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 Gene3D G3DSA:3.20.20.80 300 617 1.1E-55 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 SUPERFAMILY SSF49303 199 297 2.68E-14 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 Gene3D G3DSA:2.60.40.320 184 298 2.9E-20 T 17-03-2017 IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain GO:0004553|GO:0005975 SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 300 471 6.6E-6 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 SUPERFAMILY SSF51445 511 615 8.57E-57 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 SUPERFAMILY SSF51445 295 479 8.57E-57 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 SUPERFAMILY SSF49785 15 193 1.15E-48 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 Pfam PF02837 Glycosyl hydrolases family 2, sugar binding domain 80 155 1.3E-11 T 17-03-2017 IPR006104 Glycosyl hydrolases family 2, sugar binding domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS04720 26f41e7fac636b4db6536601a4afa50a 631 Pfam PF00703 Glycosyl hydrolases family 2 195 297 3.2E-9 T 17-03-2017 IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich GO:0004553|GO:0005975 SHXM_RS10250 a32e2df86143b69f8f36a163a66cfd71 200 SMART SM00479 8 174 3.5E-26 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS10250 a32e2df86143b69f8f36a163a66cfd71 200 Pfam PF00929 Exonuclease 11 165 6.2E-14 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS10250 a32e2df86143b69f8f36a163a66cfd71 200 SUPERFAMILY SSF53098 7 177 2.58E-32 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10250 a32e2df86143b69f8f36a163a66cfd71 200 Gene3D G3DSA:3.30.420.10 9 172 1.4E-36 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 Gene3D G3DSA:3.50.50.60 4 60 3.7E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 Gene3D G3DSA:3.50.50.60 123 220 3.7E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 Gene3D G3DSA:3.50.50.60 310 390 3.7E-38 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 Pfam PF01494 FAD binding domain 3 381 1.0E-39 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 194 209 9.1E-26 T 17-03-2017 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 9.1E-26 T 17-03-2017 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 337 353 9.1E-26 T 17-03-2017 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 322 337 9.1E-26 T 17-03-2017 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 355 373 9.1E-26 T 17-03-2017 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 SUPERFAMILY SSF51905 3 87 6.63E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 SUPERFAMILY SSF51905 129 215 6.63E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS37260 ac820a1aebc083c668c0903b24fa8e41 582 SUPERFAMILY SSF51905 309 406 6.63E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18950 c21b4856ac648928e0b2859a328865d4 425 SUPERFAMILY SSF55874 305 419 2.13E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18950 c21b4856ac648928e0b2859a328865d4 425 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 317 419 2.0E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18950 c21b4856ac648928e0b2859a328865d4 425 Gene3D G3DSA:3.30.565.10 311 420 7.7E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18950 c21b4856ac648928e0b2859a328865d4 425 Pfam PF07730 Histidine kinase 200 264 9.7E-19 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS18950 c21b4856ac648928e0b2859a328865d4 425 SMART SM00387 311 420 0.0037 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07465 02a04faaa7cf977b9b63c4d3fb22b21c 109 TIGRFAM TIGR03859 PQQ_PqqD: coenzyme PQQ biosynthesis protein PqqD 30 108 3.2E-20 T 17-03-2017 IPR022479 Coenzyme PQQ synthesis D, bacteria GO:0018189|GO:0048038 SHXM_RS07465 02a04faaa7cf977b9b63c4d3fb22b21c 109 Pfam PF05402 Coenzyme PQQ synthesis protein D (PqqD) 52 108 1.1E-10 T 17-03-2017 IPR008792 Coenzyme PQQ synthesis D SHXM_RS19420 d9c3c559418377fd1d2ba11fd1607220 245 TIGRFAM TIGR01915 npdG: NADPH-dependent F420 reductase 32 242 8.7E-79 T 17-03-2017 IPR010185 NADPH-dependent F420 reductase GO:0006740|GO:0016651|GO:0050661|GO:0055114|GO:0070967 SHXM_RS19420 d9c3c559418377fd1d2ba11fd1607220 245 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 34 128 1.8E-21 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS19420 d9c3c559418377fd1d2ba11fd1607220 245 Gene3D G3DSA:3.40.50.720 33 238 7.4E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19420 d9c3c559418377fd1d2ba11fd1607220 245 SUPERFAMILY SSF51735 33 239 3.5E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50415 d018e4e4335f4e0edd70336cf27ad38e 439 ProSitePatterns PS00216 Sugar transport proteins signature 1. 76 91 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS50415 d018e4e4335f4e0edd70336cf27ad38e 439 SUPERFAMILY SSF103473 10 419 1.44E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS50415 d018e4e4335f4e0edd70336cf27ad38e 439 Gene3D G3DSA:1.20.1250.20 242 418 3.8E-5 T 17-03-2017 SHXM_RS50415 d018e4e4335f4e0edd70336cf27ad38e 439 Gene3D G3DSA:1.20.1250.20 26 207 3.8E-23 T 17-03-2017 SHXM_RS50415 d018e4e4335f4e0edd70336cf27ad38e 439 Pfam PF07690 Major Facilitator Superfamily 25 381 1.4E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS48100 9b059c6ee83fe69ba77b04f390a781f6 336 Gene3D G3DSA:3.10.310.10 156 321 8.3E-62 T 17-03-2017 SHXM_RS48100 9b059c6ee83fe69ba77b04f390a781f6 336 PIRSF PIRSF029792 1 335 2.1E-116 T 17-03-2017 IPR008794 Proline racemase family SHXM_RS48100 9b059c6ee83fe69ba77b04f390a781f6 336 SUPERFAMILY SSF54506 1 332 9.62E-107 T 17-03-2017 SHXM_RS48100 9b059c6ee83fe69ba77b04f390a781f6 336 Gene3D G3DSA:3.10.310.10 1 155 4.6E-64 T 17-03-2017 SHXM_RS48100 9b059c6ee83fe69ba77b04f390a781f6 336 Pfam PF05544 Proline racemase 10 332 6.7E-110 T 17-03-2017 IPR008794 Proline racemase family SHXM_RS34185 c1c641650faa793666224057970ae313 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 127 140 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34185 c1c641650faa793666224057970ae313 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 113 126 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34185 c1c641650faa793666224057970ae313 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 231 245 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34185 c1c641650faa793666224057970ae313 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 64 79 2.5E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34185 c1c641650faa793666224057970ae313 288 Pfam PF12697 Alpha/beta hydrolase family 40 279 7.5E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS34185 c1c641650faa793666224057970ae313 288 SUPERFAMILY SSF53474 26 285 1.86E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34185 c1c641650faa793666224057970ae313 288 Gene3D G3DSA:3.40.50.1820 16 286 3.3E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 Gene3D G3DSA:1.10.390.10 346 486 2.5E-19 T 17-03-2017 SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 Pfam PF01433 Peptidase family M1 68 389 3.5E-31 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 SUPERFAMILY SSF55486 249 485 4.39E-50 T 17-03-2017 SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 332 347 8.1E-12 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 177 192 8.1E-12 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 351 363 8.1E-12 T 17-03-2017 IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal GO:0008237|GO:0008270 SHXM_RS37350 e03296227cf7fb0084dd4efc139d2011 526 SUPERFAMILY SSF63737 53 240 3.79E-32 T 17-03-2017 SHXM_RS13715 aac26522cb2c8d0e5b88549f20487d28 324 SUPERFAMILY SSF161098 93 293 4.58E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13715 aac26522cb2c8d0e5b88549f20487d28 324 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 115 309 1.3E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13715 aac26522cb2c8d0e5b88549f20487d28 324 Gene3D G3DSA:1.10.3720.10 93 301 9.3E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50245 a1798e6f368448ae5218a44ef39e7b66 180 Pfam PF13649 Methyltransferase domain 37 127 2.2E-16 T 17-03-2017 SHXM_RS50245 a1798e6f368448ae5218a44ef39e7b66 180 SUPERFAMILY SSF53335 27 167 9.28E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS50245 a1798e6f368448ae5218a44ef39e7b66 180 Gene3D G3DSA:3.40.50.150 33 161 2.0E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS17215 092ac750886f04fc72ce02a772c42781 179 SUPERFAMILY SSF49777 20 174 3.4E-52 T 17-03-2017 IPR008914 Phosphatidylethanolamine-binding protein SHXM_RS17215 092ac750886f04fc72ce02a772c42781 179 Gene3D G3DSA:3.90.280.10 19 174 7.4E-55 T 17-03-2017 IPR008914 Phosphatidylethanolamine-binding protein SHXM_RS17215 092ac750886f04fc72ce02a772c42781 179 Pfam PF01161 Phosphatidylethanolamine-binding protein 40 173 1.9E-38 T 17-03-2017 IPR008914 Phosphatidylethanolamine-binding protein SHXM_RS17215 092ac750886f04fc72ce02a772c42781 179 TIGRFAM TIGR00481 TIGR00481: Raf kinase inhibitor-like protein, YbhB/YbcL family 39 170 1.9E-42 T 17-03-2017 IPR005247 YbhB/YbcL SHXM_RS24995 92584b9f67ca44408a011200647761c7 170 TIGRFAM TIGR01313 therm_gnt_kin: carbohydrate kinase, thermoresistant glucokinase family 7 160 8.7E-56 T 17-03-2017 IPR006001 Carbohydrate kinase, thermoresistant glucokinase GO:0005975|GO:0016301 KEGG: 00030+2.7.1.12|MetaCyc: PWY-5530 SHXM_RS24995 92584b9f67ca44408a011200647761c7 170 Gene3D G3DSA:3.40.50.300 3 166 1.3E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24995 92584b9f67ca44408a011200647761c7 170 SUPERFAMILY SSF52540 1 162 5.65E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24995 92584b9f67ca44408a011200647761c7 170 Pfam PF01202 Shikimate kinase 13 120 3.9E-12 T 17-03-2017 IPR031322 Shikimate kinase/gluconokinase KEGG: 00400+2.7.1.71|MetaCyc: PWY-6163 SHXM_RS24190 ae3082390c7fa899bf2510b58e1aaffc 538 Pfam PF02652 L-lactate permease 15 526 1.1E-137 T 17-03-2017 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 SHXM_RS24190 ae3082390c7fa899bf2510b58e1aaffc 538 TIGRFAM TIGR00795 lctP: transporter, lactate permease (LctP) family 14 528 1.7E-136 T 17-03-2017 IPR003804 L-lactate permease GO:0005887|GO:0015129|GO:0015727 SHXM_RS00380 08823bef7bb3d093cef31e373f1341d7 181 SUPERFAMILY SSF46689 4 62 4.89E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00380 08823bef7bb3d093cef31e373f1341d7 181 SUPERFAMILY SSF48498 79 176 2.5E-8 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS00380 08823bef7bb3d093cef31e373f1341d7 181 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 52 4.3E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS00380 08823bef7bb3d093cef31e373f1341d7 181 Gene3D G3DSA:1.10.357.10 5 180 6.0E-26 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32720 f4aa07a4e46539261073f0ef02e1bbd1 325 Gene3D G3DSA:3.40.50.720 4 173 4.3E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32720 f4aa07a4e46539261073f0ef02e1bbd1 325 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 9 323 4.0E-113 T 17-03-2017 IPR005886 UDP-glucose 4-epimerase GalE GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|Reactome: R-HSA-5609977|Reactome: R-HSA-70370 SHXM_RS32720 f4aa07a4e46539261073f0ef02e1bbd1 325 Gene3D G3DSA:3.90.25.10 174 322 1.6E-42 T 17-03-2017 SHXM_RS32720 f4aa07a4e46539261073f0ef02e1bbd1 325 Pfam PF01370 NAD dependent epimerase/dehydratase family 10 245 2.8E-54 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS32720 f4aa07a4e46539261073f0ef02e1bbd1 325 SUPERFAMILY SSF51735 7 319 1.07E-86 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05645 06546475ab23376e5c19300cf12f09ce 300 Pfam PF13354 Beta-lactamase enzyme family 28 268 6.1E-42 T 17-03-2017 SHXM_RS05645 06546475ab23376e5c19300cf12f09ce 300 SUPERFAMILY SSF56601 8 152 1.73E-32 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05645 06546475ab23376e5c19300cf12f09ce 300 SUPERFAMILY SSF56601 184 296 1.73E-32 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05645 06546475ab23376e5c19300cf12f09ce 300 Gene3D G3DSA:3.40.710.10 7 151 4.6E-43 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05645 06546475ab23376e5c19300cf12f09ce 300 Gene3D G3DSA:3.40.710.10 184 299 4.6E-43 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32830 4378ffd47517d8a5473868e48ff018c2 173 Pfam PF14431 YwqJ-like deaminase 42 166 2.0E-27 T 17-03-2017 IPR025968 YwqJ-like deaminase SHXM_RS45735 e83fc274162e2a6789f8cc8bd425df6c 313 SUPERFAMILY SSF161098 94 297 1.96E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45735 e83fc274162e2a6789f8cc8bd425df6c 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 311 2.5E-38 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45735 e83fc274162e2a6789f8cc8bd425df6c 313 Gene3D G3DSA:1.10.3720.10 92 308 9.2E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04910 821e2a94ec4e071a2ac465691d0e2131 252 SUPERFAMILY SSF53335 10 247 6.48E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04910 821e2a94ec4e071a2ac465691d0e2131 252 Pfam PF13649 Methyltransferase domain 40 133 9.3E-14 T 17-03-2017 SHXM_RS04910 821e2a94ec4e071a2ac465691d0e2131 252 Gene3D G3DSA:3.40.50.150 199 228 5.1E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04910 821e2a94ec4e071a2ac465691d0e2131 252 Gene3D G3DSA:3.40.50.150 28 158 5.1E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS31725 02b0cf43f5358f4a035f8f39d2bc2de2 271 Pfam PF00378 Enoyl-CoA hydratase/isomerase 18 270 1.7E-63 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS31725 02b0cf43f5358f4a035f8f39d2bc2de2 271 Gene3D G3DSA:3.90.226.10 14 211 2.1E-66 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS31725 02b0cf43f5358f4a035f8f39d2bc2de2 271 Gene3D G3DSA:1.10.12.10 213 271 8.9E-20 T 17-03-2017 IPR014748 Crontonase, C-terminal SHXM_RS31725 02b0cf43f5358f4a035f8f39d2bc2de2 271 SUPERFAMILY SSF52096 13 271 6.01E-85 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS17915 961ad1099b12197aef20b0a0073508d5 258 ProSitePatterns PS00171 Triosephosphate isomerase active site. 171 181 - T 17-03-2017 IPR020861 Triosephosphate isomerase, active site GO:0004807 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17915 961ad1099b12197aef20b0a0073508d5 258 Gene3D G3DSA:3.20.20.70 4 255 1.7E-105 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS17915 961ad1099b12197aef20b0a0073508d5 258 SUPERFAMILY SSF51351 4 255 8.51E-91 T 17-03-2017 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17915 961ad1099b12197aef20b0a0073508d5 258 Hamap MF_00147_B Triosephosphate isomerase [tpiA]. 4 256 39.226 T 17-03-2017 IPR022896 Triosephosphate isomerase, bacterial/eukaryotic GO:0004807|GO:0006096 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17915 961ad1099b12197aef20b0a0073508d5 258 TIGRFAM TIGR00419 tim: triose-phosphate isomerase 8 247 2.4E-56 T 17-03-2017 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS17915 961ad1099b12197aef20b0a0073508d5 258 Pfam PF00121 Triosephosphate isomerase 7 253 4.5E-87 T 17-03-2017 IPR000652 Triosephosphate isomerase GO:0004807|GO:0008152 KEGG: 00010+5.3.1.1|KEGG: 00051+5.3.1.1|KEGG: 00562+5.3.1.1|KEGG: 00710+5.3.1.1|MetaCyc: PWY-1042|MetaCyc: PWY-5484|MetaCyc: PWY-6142|MetaCyc: PWY-7003|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS41455 2fa6d01ed3ca26057a776183a2475efe 217 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 65 1.0E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41455 2fa6d01ed3ca26057a776183a2475efe 217 SUPERFAMILY SSF46689 4 86 6.67E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41455 2fa6d01ed3ca26057a776183a2475efe 217 Gene3D G3DSA:1.10.357.10 5 209 7.4E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS44415 1d9ca80b1ce191e5321299034c26dd83 209 SUPERFAMILY SSF53098 26 177 6.6E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS44415 1d9ca80b1ce191e5321299034c26dd83 209 Gene3D G3DSA:3.30.420.10 27 140 7.4E-13 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10980 54c0e5032d61fa08b5c916b45a62424a 204 Pfam PF05331 Protein of unknown function (DUF742) 94 203 1.4E-32 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS40425 6f21ca27466af8e10ce2b93e89977595 225 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 122 156 6.6E-9 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS40425 6f21ca27466af8e10ce2b93e89977595 225 SUPERFAMILY SSF51161 57 208 1.66E-42 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS40425 6f21ca27466af8e10ce2b93e89977595 225 Gene3D G3DSA:2.160.10.10 24 214 1.1E-47 T 17-03-2017 SHXM_RS47655 bd2dee764ad3a6a41ed27fbf7f4186d8 305 SUPERFAMILY SSF89550 1 204 1.57E-29 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS47655 bd2dee764ad3a6a41ed27fbf7f4186d8 305 SMART SM00481 1 61 0.0016 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS47655 bd2dee764ad3a6a41ed27fbf7f4186d8 305 Gene3D G3DSA:3.20.20.140 1 151 4.1E-13 T 17-03-2017 SHXM_RS27295 31a9283c631160885ebeeae41b09bf95 521 SUPERFAMILY SSF51735 12 271 1.11E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27295 31a9283c631160885ebeeae41b09bf95 521 Pfam PF13460 NAD(P)H-binding 18 161 2.4E-20 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27295 31a9283c631160885ebeeae41b09bf95 521 SUPERFAMILY SSF55961 353 498 7.12E-8 T 17-03-2017 SHXM_RS27295 31a9283c631160885ebeeae41b09bf95 521 Gene3D G3DSA:3.40.50.720 9 235 1.4E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27295 31a9283c631160885ebeeae41b09bf95 521 Pfam PF11066 Protein of unknown function (DUF2867) 343 488 4.9E-41 T 17-03-2017 IPR021295 Protein of unknown function DUF2867 SHXM_RS29195 d0053f347282b72a26b9e7ea2a7d9eb6 177 Pfam PF02441 Flavoprotein 11 120 3.6E-7 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS29195 d0053f347282b72a26b9e7ea2a7d9eb6 177 Gene3D G3DSA:3.40.50.1950 9 153 3.9E-17 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS29195 d0053f347282b72a26b9e7ea2a7d9eb6 177 SUPERFAMILY SSF52507 6 148 7.98E-23 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS30580 68c86a2148ed1a92fbc80da216877ecc 110 SUPERFAMILY SSF103481 10 107 2.48E-10 T 17-03-2017 SHXM_RS30580 68c86a2148ed1a92fbc80da216877ecc 110 Pfam PF02694 Uncharacterised BCR, YnfA/UPF0060 family 5 109 9.9E-42 T 17-03-2017 IPR003844 Uncharacterised protein family UPF0060 GO:0016020 SHXM_RS30580 68c86a2148ed1a92fbc80da216877ecc 110 Hamap MF_00010 UPF0060 membrane protein YnfA [ynfA]. 4 109 20.482 T 17-03-2017 IPR003844 Uncharacterised protein family UPF0060 GO:0016020 SHXM_RS17120 8b86f1c7de008f3d3155496884c5a7da 382 SUPERFAMILY SSF53756 24 368 7.46E-61 T 17-03-2017 SHXM_RS17120 8b86f1c7de008f3d3155496884c5a7da 382 Pfam PF13579 Glycosyl transferase 4-like domain 25 170 8.1E-19 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS17120 8b86f1c7de008f3d3155496884c5a7da 382 Gene3D G3DSA:3.40.50.2000 185 346 6.7E-21 T 17-03-2017 SHXM_RS17120 8b86f1c7de008f3d3155496884c5a7da 382 Pfam PF00534 Glycosyl transferases group 1 187 346 6.1E-25 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS17415 0f493213dfb8f68732fd6c11c5fb1d22 269 Pfam PF02104 SURF1 family 20 231 8.0E-32 T 17-03-2017 IPR002994 Surfeit locus 1/Shy1 GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS50580 6458c05ab56d41e8081314f2949a998f 222 Gene3D G3DSA:1.10.357.10 18 206 4.2E-44 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS50580 6458c05ab56d41e8081314f2949a998f 222 SUPERFAMILY SSF46689 16 98 2.69E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50580 6458c05ab56d41e8081314f2949a998f 222 Pfam PF00440 Bacterial regulatory proteins, tetR family 30 75 5.1E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS50580 6458c05ab56d41e8081314f2949a998f 222 SUPERFAMILY SSF48498 94 200 3.46E-19 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS50580 6458c05ab56d41e8081314f2949a998f 222 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 30 43 2.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS50580 6458c05ab56d41e8081314f2949a998f 222 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 50 73 2.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31390 7f461599ef10514ba3b7ba2b72268540 336 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 109 253 1.5E-10 T 17-03-2017 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 SHXM_RS31390 7f461599ef10514ba3b7ba2b72268540 336 PIRSF PIRSF000545 15 336 5.6E-143 T 17-03-2017 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 SHXM_RS31390 7f461599ef10514ba3b7ba2b72268540 336 Hamap MF_00215 Pantothenate kinase [coaA]. 1 336 174.447 T 17-03-2017 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 SHXM_RS31390 7f461599ef10514ba3b7ba2b72268540 336 TIGRFAM TIGR00554 panK_bact: pantothenate kinase 23 335 2.1E-125 T 17-03-2017 IPR004566 Bacterial pantothenate kinase GO:0004594|GO:0005524|GO:0005737|GO:0015937 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 SHXM_RS31390 7f461599ef10514ba3b7ba2b72268540 336 Gene3D G3DSA:3.40.50.300 23 334 1.5E-104 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31390 7f461599ef10514ba3b7ba2b72268540 336 SUPERFAMILY SSF52540 21 334 6.33E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22460 690bb6f84433119ed1ff112c583ecc93 381 Pfam PF05175 Methyltransferase small domain 202 318 4.3E-12 T 17-03-2017 IPR007848 Methyltransferase small domain GO:0008168 SHXM_RS22460 690bb6f84433119ed1ff112c583ecc93 381 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature. 270 276 - T 17-03-2017 IPR002052 DNA methylase, N-6 adenine-specific, conserved site GO:0003676|GO:0008168|GO:0032259 SHXM_RS22460 690bb6f84433119ed1ff112c583ecc93 381 SUPERFAMILY SSF53335 177 319 2.39E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22460 690bb6f84433119ed1ff112c583ecc93 381 Gene3D G3DSA:3.40.50.150 175 323 1.1E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS50280 085c9d2cf68338cedf1e1ea1106fb5ba 418 Pfam PF07075 Protein of unknown function (DUF1343) 59 417 3.4E-129 T 17-03-2017 IPR008302 Uncharacterised conserved protein UCP016719 SHXM_RS50280 085c9d2cf68338cedf1e1ea1106fb5ba 418 PIRSF PIRSF016719 4 418 6.0E-152 T 17-03-2017 IPR008302 Uncharacterised conserved protein UCP016719 SHXM_RS09215 9f2a2ec83192d10e8cd3f8adb754d517 323 Pfam PF00676 Dehydrogenase E1 component 18 312 1.9E-69 T 17-03-2017 IPR001017 Dehydrogenase, E1 component GO:0008152|GO:0016624 SHXM_RS09215 9f2a2ec83192d10e8cd3f8adb754d517 323 SUPERFAMILY SSF52518 7 322 2.6E-80 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS09215 9f2a2ec83192d10e8cd3f8adb754d517 323 Gene3D G3DSA:3.40.50.970 8 322 1.7E-104 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 99 115 1.9E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 80 95 1.9E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 129 149 1.9E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 PRINTS PR00598 Bacterial regulatory protein MarR family signature 63 79 1.9E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 SMART SM00347 40 139 2.1E-18 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 Pfam PF01047 MarR family 46 103 3.4E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 Gene3D G3DSA:1.10.10.10 17 155 1.6E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01335 97ef724f48fc28167970b9e4e8bd99ec 160 SUPERFAMILY SSF46785 14 154 4.19E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01750 5a9c8f4168d77c38762f384ac425da92 261 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 21 245 2.4E-36 T 17-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 SHXM_RS01750 5a9c8f4168d77c38762f384ac425da92 261 SUPERFAMILY SSF51621 8 257 1.12E-63 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS01750 5a9c8f4168d77c38762f384ac425da92 261 Gene3D G3DSA:3.20.20.60 7 257 5.8E-66 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 SUPERFAMILY SSF46785 11 82 1.88E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 SUPERFAMILY SSF55781 83 250 2.88E-31 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 Gene3D G3DSA:3.30.450.40 93 251 2.4E-33 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 Pfam PF09339 IclR helix-turn-helix domain 13 61 8.3E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 Pfam PF01614 Bacterial transcriptional regulator 138 247 1.9E-22 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 SMART SM00346 10 99 8.6E-4 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS09065 9bb824c2a84459654edfb6758eb7e14a 279 Gene3D G3DSA:1.10.10.10 10 82 1.7E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07410 3bb0f75a0e8d3fd4164d0fb56fa47eaa 112 Pfam PF01638 HxlR-like helix-turn-helix 16 102 2.4E-32 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS07410 3bb0f75a0e8d3fd4164d0fb56fa47eaa 112 SUPERFAMILY SSF46785 3 107 2.41E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07410 3bb0f75a0e8d3fd4164d0fb56fa47eaa 112 Gene3D G3DSA:1.10.10.10 4 107 1.9E-41 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50005 ca6a8622a2b2a6627391a5f09c0e675f 410 Pfam PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain 107 173 7.0E-6 T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS50005 ca6a8622a2b2a6627391a5f09c0e675f 410 Gene3D G3DSA:3.30.470.20 100 309 5.7E-21 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS50005 ca6a8622a2b2a6627391a5f09c0e675f 410 SUPERFAMILY SSF56059 98 312 4.95E-31 T 17-03-2017 SHXM_RS49990 53dec4810066fedaa4401dd5cabd8fb1 389 SUPERFAMILY SSF55729 188 347 2.57E-13 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS49990 53dec4810066fedaa4401dd5cabd8fb1 389 Pfam PF13480 Acetyltransferase (GNAT) domain 196 333 2.2E-10 T 17-03-2017 SHXM_RS04085 ec369b3c6772ea7f67830b233272dada 418 SUPERFAMILY SSF103473 15 400 1.7E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS04085 ec369b3c6772ea7f67830b233272dada 418 Gene3D G3DSA:1.20.1250.20 223 397 1.2E-11 T 17-03-2017 SHXM_RS04085 ec369b3c6772ea7f67830b233272dada 418 Gene3D G3DSA:1.20.1250.20 15 201 4.2E-20 T 17-03-2017 SHXM_RS04085 ec369b3c6772ea7f67830b233272dada 418 Pfam PF05977 Transmembrane secretion effector 12 399 1.1E-30 T 17-03-2017 IPR010290 Transmembrane secretion effector SHXM_RS45925 a08846794b09fa7e8a4da42e0779f40f 245 SMART SM00014 92 205 7.6E-7 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS45925 a08846794b09fa7e8a4da42e0779f40f 245 Gene3D G3DSA:1.20.144.10 39 203 1.9E-22 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS45925 a08846794b09fa7e8a4da42e0779f40f 245 SUPERFAMILY SSF48317 13 211 1.57E-32 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS45925 a08846794b09fa7e8a4da42e0779f40f 245 Pfam PF01569 PAP2 superfamily 127 204 1.2E-13 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 489 506 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 506 525 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 435 454 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 468 480 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 343 357 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 383 398 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 421 435 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 PRINTS PR00819 CbxX/CfqX superfamily signature 566 578 2.9E-50 T 17-03-2017 IPR000641 CbxX/CfqX GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 SMART SM00382 380 521 1.5E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 385 518 1.0E-13 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 Gene3D G3DSA:3.40.50.300 342 518 2.7E-20 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 SUPERFAMILY SSF48452 175 243 1.77E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 SUPERFAMILY SSF48452 14 51 1.77E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 SUPERFAMILY SSF48452 337 354 1.77E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 SUPERFAMILY SSF52540 344 588 4.49E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 Gene3D G3DSA:1.25.40.10 18 52 4.2E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12120 1bebfe4e73148ab711e8b2c4e0c95d21 629 Gene3D G3DSA:1.25.40.10 176 255 4.2E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 Pfam PF07883 Cupin domain 131 191 2.0E-7 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 SUPERFAMILY SSF47413 15 81 1.34E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 Pfam PF13560 Helix-turn-helix domain 19 72 1.5E-10 T 17-03-2017 SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 SMART SM00530 19 74 1.1E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 Gene3D G3DSA:2.60.120.10 105 193 3.8E-20 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 Gene3D G3DSA:1.10.260.40 10 83 3.8E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06765 e1900efde60bc7e64c4118e6e725d1bf 200 SUPERFAMILY SSF51182 80 191 2.9E-20 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 Gene3D G3DSA:1.10.10.10 123 185 5.2E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 24 182 1.3E-28 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 SUPERFAMILY SSF88659 123 185 1.94E-15 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 Pfam PF08281 Sigma-70, region 4 129 181 1.2E-15 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 SUPERFAMILY SSF88946 8 114 6.47E-30 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 Pfam PF04542 Sigma-70 region 2 30 96 3.2E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS28055 0168b1fa06d833dbfbeb1f51ab8b9cc0 229 Gene3D G3DSA:1.10.1740.10 9 116 7.9E-32 T 17-03-2017 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 Pfam PF07687 Peptidase dimerisation domain 174 273 6.5E-19 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 Pfam PF01546 Peptidase family M20/M25/M40 72 366 9.7E-29 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 Gene3D G3DSA:3.40.630.10 308 368 9.9E-57 T 17-03-2017 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 Gene3D G3DSA:3.40.630.10 10 185 9.9E-57 T 17-03-2017 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 SUPERFAMILY SSF55031 176 274 1.5E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 ProSitePatterns PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 105 143 - T 17-03-2017 IPR001261 ArgE/DapE/ACY1/CPG2/YscS, conserved site GO:0006508|GO:0008237 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 SUPERFAMILY SSF53187 9 176 1.03E-47 T 17-03-2017 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 SUPERFAMILY SSF53187 285 368 1.03E-47 T 17-03-2017 SHXM_RS48545 0942ed981c713fd02a735a21f97c89f1 368 Gene3D G3DSA:3.30.70.360 186 273 8.7E-27 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS48350 a27b65305eccc9ee0189b8b141ee1873 274 Gene3D G3DSA:1.10.3720.10 5 261 5.7E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48350 a27b65305eccc9ee0189b8b141ee1873 274 SUPERFAMILY SSF161098 6 274 7.98E-65 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48350 a27b65305eccc9ee0189b8b141ee1873 274 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 90 263 2.7E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34725 430515aac3219c90601db92010a9b163 308 SUPERFAMILY SSF51735 14 299 3.89E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34725 430515aac3219c90601db92010a9b163 308 Pfam PF05368 NmrA-like family 14 248 1.5E-44 T 17-03-2017 IPR008030 NmrA-like domain Reactome: R-HSA-70635 SHXM_RS34725 430515aac3219c90601db92010a9b163 308 Gene3D G3DSA:3.40.50.720 10 245 2.2E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS01100 c86f856d6fe98ebbfeea19d3fee89b42 128 Gene3D G3DSA:3.10.180.10 1 121 1.5E-29 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS01100 c86f856d6fe98ebbfeea19d3fee89b42 128 SUPERFAMILY SSF54593 7 120 1.01E-24 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS01100 c86f856d6fe98ebbfeea19d3fee89b42 128 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 8 119 1.6E-10 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS46650 9d94c87a66281a536b016a66735b8630 200 Pfam PF03596 Cadmium resistance transporter 14 198 7.0E-29 T 17-03-2017 IPR004676 Cadmium resistance transporter SHXM_RS03470 0b0c2e62c392a8c3087da455cb6e47c7 332 Gene3D G3DSA:3.40.50.10440 12 183 2.8E-60 T 17-03-2017 SHXM_RS03470 0b0c2e62c392a8c3087da455cb6e47c7 332 Gene3D G3DSA:3.30.1180.20 187 331 5.4E-41 T 17-03-2017 SHXM_RS03470 0b0c2e62c392a8c3087da455cb6e47c7 332 SUPERFAMILY SSF82549 12 331 4.97E-98 T 17-03-2017 SHXM_RS03470 0b0c2e62c392a8c3087da455cb6e47c7 332 Pfam PF02733 Dak1 domain 19 329 4.7E-103 T 17-03-2017 IPR004006 DhaK domain GO:0004371|GO:0006071 Reactome: R-HSA-168928|Reactome: R-HSA-70350 SHXM_RS34430 2cac1deb6ac05f9d783311c0a66a4b05 107 Pfam PF00893 Small Multidrug Resistance protein 1 93 8.2E-25 T 17-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 SHXM_RS34430 2cac1deb6ac05f9d783311c0a66a4b05 107 SUPERFAMILY SSF103481 6 105 2.62E-17 T 17-03-2017 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 SUPERFAMILY SSF55347 109 217 1.72E-39 T 17-03-2017 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 PIRSF PIRSF000161 2 250 9.4E-60 T 17-03-2017 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 TIGRFAM TIGR00036 dapB: 4-hydroxy-tetrahydrodipicolinate reductase 43 248 4.3E-51 T 17-03-2017 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 Pfam PF01113 Dihydrodipicolinate reductase, N-terminus 5 108 7.8E-22 T 17-03-2017 IPR000846 Dihydrodipicolinate reductase, N-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 Gene3D G3DSA:3.40.50.720 3 143 1.4E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 SUPERFAMILY SSF51735 4 135 1.46E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 ProSitePatterns PS01298 Dihydrodipicolinate reductase signature. 130 147 - T 17-03-2017 IPR022664 Dihydrodipicolinate reductase, conserved site GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 Pfam PF05173 Dihydrodipicolinate reductase, C-terminus 111 247 1.6E-28 T 17-03-2017 IPR022663 Dihydrodipicolinate reductase, C-terminal GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS37080 d3266197cd8b8eacd942a50cd657119f 250 Hamap MF_00102 4-hydroxy-tetrahydrodipicolinate reductase [dapB]. 4 248 29.13 T 17-03-2017 IPR023940 Dihydrodipicolinate reductase GO:0008839|GO:0009089|GO:0055114 KEGG: 00261+1.17.1.8|KEGG: 00300+1.17.1.8|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097 SHXM_RS01255 c090bb5e4836112cb3996880f0b5dcd8 322 Gene3D G3DSA:3.40.50.1820 3 314 1.1E-78 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01255 c090bb5e4836112cb3996880f0b5dcd8 322 Pfam PF07859 alpha/beta hydrolase fold 85 291 9.7E-51 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS01255 c090bb5e4836112cb3996880f0b5dcd8 322 SUPERFAMILY SSF53474 37 316 5.31E-63 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 Pfam PF00196 Bacterial regulatory proteins, luxR family 140 195 9.5E-15 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 SUPERFAMILY SSF52172 2 129 6.4E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 141 155 1.4E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 155 171 1.4E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 183 1.4E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 SUPERFAMILY SSF46894 124 201 4.42E-19 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 Gene3D G3DSA:3.40.50.2300 2 144 2.5E-39 T 17-03-2017 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 SMART SM00448 2 115 1.5E-28 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 Gene3D G3DSA:1.10.10.10 145 201 7.8E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 Pfam PF00072 Response regulator receiver domain 4 115 3.9E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS34020 2d2e3e15ff772635f5849bc4814b6a7e 201 SMART SM00421 138 195 5.6E-19 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16085 90f7717b68eaeb305b945f009ae25c15 349 Gene3D G3DSA:3.20.20.30 1 337 3.2E-77 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16085 90f7717b68eaeb305b945f009ae25c15 349 SUPERFAMILY SSF51679 1 338 4.19E-71 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16085 90f7717b68eaeb305b945f009ae25c15 349 Pfam PF00296 Luciferase-like monooxygenase 17 318 4.5E-79 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS16085 90f7717b68eaeb305b945f009ae25c15 349 TIGRFAM TIGR03559 F420_Rv3520c: probable F420-dependent oxidoreductase, Rv3520c family 2 322 6.4E-122 T 17-03-2017 IPR019951 F420-dependent oxidoreductase-predicted, Rv3520c SHXM_RS10405 120e3251c1255e8791cb12888df8c6d6 288 SUPERFAMILY SSF103481 212 287 4.84E-12 T 17-03-2017 SHXM_RS10405 120e3251c1255e8791cb12888df8c6d6 288 Pfam PF00892 EamA-like transporter family 3 131 5.8E-10 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS10405 120e3251c1255e8791cb12888df8c6d6 288 Pfam PF00892 EamA-like transporter family 146 286 3.5E-10 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS10405 120e3251c1255e8791cb12888df8c6d6 288 SUPERFAMILY SSF103481 39 134 3.14E-11 T 17-03-2017 SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 Gene3D G3DSA:3.40.50.620 59 221 1.4E-12 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 Pfam PF09179 TilS substrate binding domain 296 362 6.8E-10 T 17-03-2017 IPR015262 tRNA(Ile)-lysidine synthase , substrate-binding domain GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 SUPERFAMILY SSF52402 59 269 9.43E-48 T 17-03-2017 SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 Hamap MF_01161 tRNA(Ile)-lysidine synthase [tilS]. 53 356 20.395 T 17-03-2017 IPR012094 tRNA(Ile)-lysidine synthase GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 Pfam PF01171 PP-loop family 59 237 5.3E-39 T 17-03-2017 IPR011063 tRNA(Ile)-lysidine/2-thiocytidine synthase, N-terminal Reactome: R-HSA-6782315 SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 TIGRFAM TIGR02432 lysidine_TilS_N: tRNA(Ile)-lysidine synthetase 59 240 9.5E-44 T 17-03-2017 IPR012795 tRNA(Ile)-lysidine synthase, N-terminal GO:0000166|GO:0005524|GO:0005737|GO:0008033|GO:0016879 SHXM_RS26460 0b5509b16b281ae94aa1b0944ea54daf 367 SUPERFAMILY SSF82829 249 362 6.54E-14 T 17-03-2017 SHXM_RS01415 ba3ea99d1ac786bf1716de2c5684d293 415 Gene3D G3DSA:3.20.70.20 54 402 1.1E-69 T 17-03-2017 SHXM_RS01415 ba3ea99d1ac786bf1716de2c5684d293 415 Pfam PF05167 Uncharacterised ACR (DUF711) 64 392 1.7E-56 T 17-03-2017 IPR007841 Uncharacterised protein family UPF0210 SHXM_RS01415 ba3ea99d1ac786bf1716de2c5684d293 415 SUPERFAMILY SSF51998 58 403 3.94E-68 T 17-03-2017 SHXM_RS22450 1fe5b2ed666b4869bff35282ed69d000 285 SUPERFAMILY SSF53335 46 79 4.76E-6 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22450 1fe5b2ed666b4869bff35282ed69d000 285 SUPERFAMILY SSF53335 115 180 4.76E-6 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS38355 38b42d448a3ea743fa923ea9e043074e 240 Pfam PF00535 Glycosyl transferase family 2 13 162 1.7E-20 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS38355 38b42d448a3ea743fa923ea9e043074e 240 SUPERFAMILY SSF53448 7 219 3.87E-37 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS38355 38b42d448a3ea743fa923ea9e043074e 240 Gene3D G3DSA:3.90.550.10 34 190 2.1E-19 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS10085 6d6026b29cce020bb16cad63c9baa77a 126 Pfam PF07811 TadE-like protein 1 39 4.3E-7 T 17-03-2017 IPR012495 TadE-like SHXM_RS27090 e69d0ea903e309dc2f4e3fd7abf8122c 128 Gene3D G3DSA:3.10.180.10 4 126 9.5E-24 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS27090 e69d0ea903e309dc2f4e3fd7abf8122c 128 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 5 119 3.1E-6 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS27090 e69d0ea903e309dc2f4e3fd7abf8122c 128 SUPERFAMILY SSF54593 5 124 9.8E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS39770 0d830c754e6234ca54d3791f438308a1 61 Gene3D G3DSA:1.10.443.10 10 57 9.4E-4 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 SMART SM00418 281 359 7.2E-14 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 Pfam PF12840 Helix-turn-helix domain 284 339 3.6E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 Gene3D G3DSA:1.10.10.10 271 359 4.6E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 SUPERFAMILY SSF46785 274 353 5.06E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 330 345 5.6E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 315 330 5.6E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS07905 1a08a095c1982fde44e031ccfa50a3b6 363 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 283 298 5.6E-6 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 Gene3D G3DSA:3.50.50.60 281 358 7.0E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 Gene3D G3DSA:3.50.50.60 1 168 7.0E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 SUPERFAMILY SSF51905 2 163 1.15E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 SUPERFAMILY SSF51905 280 370 1.15E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 Pfam PF01494 FAD binding domain 106 335 1.4E-12 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 142 157 4.4E-21 T 17-03-2017 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 308 324 4.4E-21 T 17-03-2017 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 293 308 4.4E-21 T 17-03-2017 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 2 24 4.4E-21 T 17-03-2017 SHXM_RS47330 1a6911716b6a4b232f058219eba996f0 377 Pfam PF13450 NAD(P)-binding Rossmann-like domain 5 43 1.1E-4 T 17-03-2017 SHXM_RS01675 21c1088987c716fef043788f7204472f 261 SUPERFAMILY SSF161098 3 250 3.74E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01675 21c1088987c716fef043788f7204472f 261 Gene3D G3DSA:1.10.3720.10 7 251 1.0E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01675 21c1088987c716fef043788f7204472f 261 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 75 245 3.1E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45245 4b13f4d2fad4bc4fc7983911211ae406 223 Pfam PF01476 LysM domain 174 220 7.9E-10 T 17-03-2017 IPR018392 LysM domain SHXM_RS45245 4b13f4d2fad4bc4fc7983911211ae406 223 SMART SM00257 173 220 1.0E-8 T 17-03-2017 IPR018392 LysM domain SHXM_RS45245 4b13f4d2fad4bc4fc7983911211ae406 223 SUPERFAMILY SSF54106 173 220 1.44E-6 T 17-03-2017 IPR018392 LysM domain SHXM_RS45245 4b13f4d2fad4bc4fc7983911211ae406 223 Gene3D G3DSA:3.10.350.10 173 220 1.1E-9 T 17-03-2017 IPR018392 LysM domain SHXM_RS30190 1ab86508e74f81ec66696add2f470ab9 441 Pfam PF11209 Protein of unknown function (DUF2993) 125 274 2.2E-25 T 17-03-2017 IPR021373 Protein of unknown function DUF2993 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 SUPERFAMILY SSF48371 236 296 5.76E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 SUPERFAMILY SSF48371 651 674 5.76E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 SUPERFAMILY SSF48371 481 506 5.76E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 SUPERFAMILY SSF48371 594 611 5.76E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 SUPERFAMILY SSF48371 96 184 5.76E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 SUPERFAMILY SSF48371 329 427 5.76E-9 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS09390 7e233a8b643cdec7c16f80a0da6ac747 715 Gene3D G3DSA:1.25.10.10 245 440 6.3E-6 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 Pfam PF02789 Cytosol aminopeptidase family, N-terminal domain 20 142 2.3E-22 T 17-03-2017 IPR008283 Peptidase M17, leucyl aminopeptidase, N-terminal GO:0004177|GO:0005622|GO:0006508 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 Pfam PF00883 Cytosol aminopeptidase family, catalytic domain 195 501 1.2E-113 T 17-03-2017 IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal GO:0004177|GO:0005622|GO:0006508 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 ProSitePatterns PS00631 Cytosol aminopeptidase signature. 355 362 - T 17-03-2017 IPR000819 Peptidase M17, leucyl aminopeptidase, C-terminal GO:0004177|GO:0005622|GO:0006508 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 PRINTS PR00481 Cytosol aminopeptidase signature 292 313 6.9E-50 T 17-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 PRINTS PR00481 Cytosol aminopeptidase signature 329 350 6.9E-50 T 17-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 PRINTS PR00481 Cytosol aminopeptidase signature 379 394 6.9E-50 T 17-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 PRINTS PR00481 Cytosol aminopeptidase signature 270 287 6.9E-50 T 17-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 PRINTS PR00481 Cytosol aminopeptidase signature 351 371 6.9E-50 T 17-03-2017 IPR011356 Peptidase M17, leucine aminopeptidase/peptidase B GO:0004177|GO:0005737|GO:0008235|GO:0019538|GO:0030145 KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 Gene3D G3DSA:3.40.220.10 16 187 3.3E-37 T 17-03-2017 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 SUPERFAMILY SSF53187 189 505 2.3E-111 T 17-03-2017 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 Hamap MF_00181 Probable cytosol aminopeptidase [pepA]. 4 509 33.829 T 17-03-2017 IPR023042 Peptidase M17, leucine aminopeptidase KEGG: 00480+3.4.11.1 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 Gene3D G3DSA:3.40.630.10 188 507 3.9E-128 T 17-03-2017 SHXM_RS19005 bbd95e741de63b5179522f8e162a38e1 513 SUPERFAMILY SSF52949 17 143 4.88E-23 T 17-03-2017 SHXM_RS22615 21033f59e4f1dc2289d38a8697992c40 310 Gene3D G3DSA:3.20.20.70 14 300 2.7E-84 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS22615 21033f59e4f1dc2289d38a8697992c40 310 SUPERFAMILY SSF51569 12 303 1.39E-68 T 17-03-2017 SHXM_RS22615 21033f59e4f1dc2289d38a8697992c40 310 Pfam PF00682 HMGL-like 15 286 2.3E-47 T 17-03-2017 IPR000891 Pyruvate carboxyltransferase GO:0003824 SHXM_RS02160 d3bed39adb1411a4c14454bd87a53744 144 SUPERFAMILY SSF54637 22 119 6.81E-16 T 17-03-2017 IPR029069 HotDog domain SHXM_RS02160 d3bed39adb1411a4c14454bd87a53744 144 Gene3D G3DSA:3.10.129.10 8 130 7.5E-19 T 17-03-2017 IPR029069 HotDog domain SHXM_RS02160 d3bed39adb1411a4c14454bd87a53744 144 Pfam PF07977 FabA-like domain 9 114 2.7E-9 T 17-03-2017 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Gene3D G3DSA:2.120.10.90 513 772 5.1E-39 T 17-03-2017 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Pfam PF00521 DNA gyrase/topoisomerase IV, subunit A 42 478 2.3E-147 T 17-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 SUPERFAMILY SSF101904 513 779 6.02E-41 T 17-03-2017 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 SUPERFAMILY SSF56719 41 498 1.83E-164 T 17-03-2017 IPR013760 DNA topoisomerase, type IIA-like domain GO:0003918|GO:0005524 Reactome: R-HSA-4615885 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 SMART SM00434 21 476 3.8E-254 T 17-03-2017 IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal GO:0003677|GO:0003918|GO:0005524|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Gene3D G3DSA:3.30.1360.40 247 344 4.2E-28 T 17-03-2017 IPR024946 Arginine repressor C-terminal-like domain SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 669 714 9.0E-7 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Pfam PF03989 DNA gyrase C-terminal domain, beta-propeller 740 769 0.01 T 17-03-2017 IPR006691 DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel GO:0003677|GO:0003916|GO:0005524|GO:0005694|GO:0006265 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Gene3D G3DSA:3.90.199.10 345 410 9.1E-111 T 17-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS37510 184be03785fc5b5c4b306c0873c1b63a 817 Gene3D G3DSA:3.90.199.10 41 246 9.1E-111 T 17-03-2017 IPR013758 DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta GO:0003677|GO:0003918|GO:0005524|GO:0006259|GO:0006265 Reactome: R-HSA-4615885 SHXM_RS19795 f8f7a373fdc55e5d5b822722e816a795 204 SUPERFAMILY SSF46689 14 84 1.45E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS19795 f8f7a373fdc55e5d5b822722e816a795 204 Gene3D G3DSA:1.10.357.10 18 191 5.8E-30 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS19795 f8f7a373fdc55e5d5b822722e816a795 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 1.9E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS19795 f8f7a373fdc55e5d5b822722e816a795 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 44 67 1.9E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS19795 f8f7a373fdc55e5d5b822722e816a795 204 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 68 4.1E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS28870 d72b668dbfe2d1763a5e9b52b100507a 184 Gene3D G3DSA:3.90.79.10 46 180 1.4E-18 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS28870 d72b668dbfe2d1763a5e9b52b100507a 184 Pfam PF00293 NUDIX domain 45 169 2.9E-12 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS28870 d72b668dbfe2d1763a5e9b52b100507a 184 SUPERFAMILY SSF55811 27 177 5.01E-18 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS05225 7ca4344d0e187c999c4a87cb3da451aa 365 SUPERFAMILY SSF51735 22 356 5.57E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05225 7ca4344d0e187c999c4a87cb3da451aa 365 Gene3D G3DSA:3.40.50.720 25 352 1.3E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05225 7ca4344d0e187c999c4a87cb3da451aa 365 Pfam PF01370 NAD dependent epimerase/dehydratase family 25 265 6.2E-26 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS46410 ca37c696d3df93ae82feb68db69b46c8 161 Gene3D G3DSA:2.60.120.10 12 135 4.8E-35 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS46410 ca37c696d3df93ae82feb68db69b46c8 161 Pfam PF07883 Cupin domain 43 110 2.7E-20 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS46410 ca37c696d3df93ae82feb68db69b46c8 161 SUPERFAMILY SSF51182 4 135 6.5E-29 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS04025 ea5b64902936352a40ea56112e0b9eb1 389 Pfam PF00144 Beta-lactamase 24 382 5.0E-67 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS04025 ea5b64902936352a40ea56112e0b9eb1 389 SUPERFAMILY SSF56601 255 373 6.22E-69 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS04025 ea5b64902936352a40ea56112e0b9eb1 389 SUPERFAMILY SSF56601 12 224 6.22E-69 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS04025 ea5b64902936352a40ea56112e0b9eb1 389 Gene3D G3DSA:3.40.710.10 5 386 4.5E-74 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39100 b74d31ee8de237febab39baa972a013c 279 Pfam PF00005 ABC transporter 30 184 2.1E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS39100 b74d31ee8de237febab39baa972a013c 279 Gene3D G3DSA:3.40.50.300 7 249 1.0E-56 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39100 b74d31ee8de237febab39baa972a013c 279 SUPERFAMILY SSF52540 15 242 1.46E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39100 b74d31ee8de237febab39baa972a013c 279 SMART SM00382 39 232 7.0E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS39100 b74d31ee8de237febab39baa972a013c 279 ProSitePatterns PS00211 ABC transporters family signature. 156 170 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS03045 ec36328274aa12854648b9824f7ff843 102 SUPERFAMILY SSF47336 35 93 4.45E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS03045 ec36328274aa12854648b9824f7ff843 102 Gene3D G3DSA:1.10.1200.10 20 92 2.5E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS03045 ec36328274aa12854648b9824f7ff843 102 Pfam PF00550 Phosphopantetheine attachment site 40 89 5.0E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS13345 6ec053ccb5783d9aa7e2a33e222b3092 287 TIGRFAM TIGR03464 HpnC: squalene synthase HpnC 3 282 5.0E-98 T 17-03-2017 IPR017827 Squalene synthase HpnC SHXM_RS13345 6ec053ccb5783d9aa7e2a33e222b3092 287 Pfam PF00494 Squalene/phytoene synthase 4 274 1.2E-69 T 17-03-2017 IPR002060 Squalene/phytoene synthase GO:0009058|GO:0016740 SHXM_RS13345 6ec053ccb5783d9aa7e2a33e222b3092 287 Gene3D G3DSA:1.10.600.10 8 274 4.0E-49 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13345 6ec053ccb5783d9aa7e2a33e222b3092 287 SUPERFAMILY SSF48576 6 285 1.87E-58 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS13045 b4bf6eef49803caeada52a16fcbb164a 383 SUPERFAMILY SSF103481 239 316 1.44E-8 T 17-03-2017 SHXM_RS13045 b4bf6eef49803caeada52a16fcbb164a 383 Pfam PF00892 EamA-like transporter family 182 311 4.4E-11 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS13045 b4bf6eef49803caeada52a16fcbb164a 383 Pfam PF00892 EamA-like transporter family 38 166 1.8E-8 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS13045 b4bf6eef49803caeada52a16fcbb164a 383 SUPERFAMILY SSF103481 73 171 2.75E-6 T 17-03-2017 SHXM_RS31285 3e9236d418dc4cf4e779da52893713a2 87 Pfam PF01176 Translation initiation factor 1A / IF-1 22 85 6.2E-29 T 17-03-2017 IPR006196 RNA-binding domain, S1, IF1 type GO:0003723|GO:0003743|GO:0006413 SHXM_RS31285 3e9236d418dc4cf4e779da52893713a2 87 Hamap MF_00075 Translation initiation factor IF-1 [infA]. 16 87 26.761 T 17-03-2017 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 SHXM_RS31285 3e9236d418dc4cf4e779da52893713a2 87 SMART SM00316 19 87 6.0E-5 T 17-03-2017 IPR022967 RNA-binding domain, S1 SHXM_RS31285 3e9236d418dc4cf4e779da52893713a2 87 SUPERFAMILY SSF50249 17 86 4.41E-28 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31285 3e9236d418dc4cf4e779da52893713a2 87 Gene3D G3DSA:2.40.50.140 12 87 1.8E-40 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31285 3e9236d418dc4cf4e779da52893713a2 87 TIGRFAM TIGR00008 infA: translation initiation factor IF-1 18 86 1.2E-37 T 17-03-2017 IPR004368 Translation initiation factor IF-1 GO:0003743|GO:0006413 SHXM_RS21735 4a30eda0a29f636d057c29baa96b060d 842 Pfam PF02687 FtsX-like permease family 274 394 8.1E-18 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS21735 4a30eda0a29f636d057c29baa96b060d 842 Pfam PF02687 FtsX-like permease family 726 838 3.6E-14 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 5 22 1.2E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 170 187 1.2E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 1.2E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 168 1.2E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 1.2E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 149 168 8.8E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 8.8E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 129 137 8.8E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 4 185 2.6E-4 T 17-03-2017 SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 Gene3D G3DSA:3.40.50.720 4 229 7.6E-64 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 SUPERFAMILY SSF51735 2 238 7.79E-62 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 136 164 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS30570 23e5a050b61fa96b8e1aca5a7d3f0e8f 251 Pfam PF00106 short chain dehydrogenase 5 186 6.6E-50 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS21615 eab07e5d78563d2473c4b7a12f8c7ce8 258 Pfam PF10105 Uncharacterized protein conserved in bacteria (DUF2344) 3 191 5.6E-51 T 17-03-2017 IPR018768 Domain of unknown function DUF2344 SHXM_RS21615 eab07e5d78563d2473c4b7a12f8c7ce8 258 TIGRFAM TIGR03936 sam_1_link_chp: radical SAM-linked protein 3 216 7.4E-57 T 17-03-2017 IPR018768 Domain of unknown function DUF2344 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 SUPERFAMILY SSF88946 3 75 1.49E-11 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 Pfam PF04542 Sigma-70 region 2 17 78 4.7E-7 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 SUPERFAMILY SSF88659 90 162 2.24E-17 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 Gene3D G3DSA:1.10.1740.10 8 78 1.5E-12 T 17-03-2017 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 Gene3D G3DSA:1.10.10.10 97 161 7.4E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 5 162 2.1E-60 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 10 159 3.5E-26 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 ProSitePatterns PS01063 Sigma-70 factors ECF subfamily signature. 34 65 - T 17-03-2017 IPR000838 RNA polymerase sigma factor 70, ECF, conserved site GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS30280 ead7691a86f86b091e7dedcd8384b5a9 203 Pfam PF08281 Sigma-70, region 4 104 155 7.4E-17 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SUPERFAMILY SSF52058 76 365 2.04E-65 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 142 164 0.67 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 234 256 3.5 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 211 233 0.33 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 188 210 0.053 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 303 325 23.0 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 257 279 19.0 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 280 302 4.1 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 97 119 91.0 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 165 186 0.57 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00369 326 349 0.98 T 17-03-2017 IPR003591 Leucine-rich repeat, typical subtype SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 Pfam PF13855 Leucine rich repeat 231 270 1.6E-6 T 17-03-2017 IPR001611 Leucine-rich repeat GO:0005515 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 Pfam PF13855 Leucine rich repeat 306 359 1.1E-6 T 17-03-2017 IPR001611 Leucine-rich repeat GO:0005515 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 Pfam PF13855 Leucine rich repeat 121 178 8.6E-10 T 17-03-2017 IPR001611 Leucine-rich repeat GO:0005515 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 Gene3D G3DSA:3.80.10.10 237 367 1.4E-32 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 Gene3D G3DSA:3.80.10.10 68 236 2.9E-43 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 Pfam PF12799 Leucine Rich repeats (2 copies) 189 226 2.6E-7 T 17-03-2017 IPR025875 Leucine rich repeat 4 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 119 138 87.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 326 345 7.4 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 257 276 47.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 165 184 0.67 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 280 299 14.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 142 161 85.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 303 322 45.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 97 115 480.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 188 207 0.74 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 234 253 58.0 T 17-03-2017 SHXM_RS09910 c736e03e61b7e4c0241959c0b27a32d9 367 SMART SM00364 211 230 34.0 T 17-03-2017 SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 SUPERFAMILY SSF51735 16 260 2.02E-79 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 Gene3D G3DSA:3.40.50.720 11 260 2.2E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 19 36 5.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 170 189 5.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 224 244 5.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 143 159 5.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 92 103 5.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 191 208 5.9E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 26 260 9.4E-60 T 17-03-2017 SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 18 201 0.0052 T 17-03-2017 SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 170 189 9.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 149 157 9.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 92 103 9.0E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15180 e96ef33c9b72d47c12be57ab8e29cb63 268 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 157 185 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS29295 2c11f38902c280f9f9ae032bd6e3c77a 178 Gene3D G3DSA:1.10.10.10 18 97 1.5E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29295 2c11f38902c280f9f9ae032bd6e3c77a 178 SUPERFAMILY SSF46785 19 124 1.51E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29295 2c11f38902c280f9f9ae032bd6e3c77a 178 Pfam PF12802 MarR family 35 94 1.5E-8 T 17-03-2017 SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 Gene3D G3DSA:3.40.50.720 8 254 2.9E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 21 252 2.3E-53 T 17-03-2017 SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 6.4E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 178 195 6.4E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 6.4E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 6.4E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 6.4E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 6.4E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 135 143 1.5E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 1.5E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 1.5E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS34830 7a06bd1d93212637ee55be0091d04d1a 256 SUPERFAMILY SSF51735 11 254 8.06E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41005 e95457c86ada7e8907625b25c40f22b4 339 Gene3D G3DSA:3.40.710.10 6 329 5.4E-75 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS41005 e95457c86ada7e8907625b25c40f22b4 339 Pfam PF00144 Beta-lactamase 6 328 8.9E-63 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS41005 e95457c86ada7e8907625b25c40f22b4 339 SUPERFAMILY SSF56601 4 322 3.35E-73 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS40540 5e4abb05dc66f3324ec5c355cb7da9e9 128 Pfam PF01042 Endoribonuclease L-PSP 11 121 2.5E-28 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS40540 5e4abb05dc66f3324ec5c355cb7da9e9 128 Gene3D G3DSA:3.30.1330.40 5 123 2.7E-37 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS40540 5e4abb05dc66f3324ec5c355cb7da9e9 128 SUPERFAMILY SSF55298 3 123 1.57E-36 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 Gene3D G3DSA:3.20.20.70 8 155 5.8E-30 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 SMART SM00116 96 144 7.4E-13 T 17-03-2017 IPR000644 CBS domain SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 SMART SM00116 15 63 4.0 T 17-03-2017 IPR000644 CBS domain SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 PIRSF PIRSF036990 6 219 4.4E-65 T 17-03-2017 IPR017080 Uncharacterised conserved protein UCP036990, CBS, BON SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 Pfam PF00571 CBS domain 92 143 7.4E-15 T 17-03-2017 IPR000644 CBS domain SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 Pfam PF00571 CBS domain 8 59 1.3E-8 T 17-03-2017 IPR000644 CBS domain SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 Pfam PF04972 BON domain 147 211 4.2E-13 T 17-03-2017 IPR007055 BON domain SHXM_RS43015 993f21bb514d4fa1ea31ea2a9943f25e 222 SUPERFAMILY SSF54631 6 149 1.1E-32 T 17-03-2017 SHXM_RS39835 d103fb011cec0e0bd5c4d57095bfd211 185 SUPERFAMILY SSF48498 76 158 4.77E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS39835 d103fb011cec0e0bd5c4d57095bfd211 185 Pfam PF00440 Bacterial regulatory proteins, tetR family 8 52 5.0E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39835 d103fb011cec0e0bd5c4d57095bfd211 185 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 52 1.1E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39835 d103fb011cec0e0bd5c4d57095bfd211 185 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 8 21 1.1E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39835 d103fb011cec0e0bd5c4d57095bfd211 185 Gene3D G3DSA:1.10.357.10 6 163 2.1E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS39835 d103fb011cec0e0bd5c4d57095bfd211 185 SUPERFAMILY SSF46689 6 78 1.7E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25205 8762d5a42b2749b8cdc4f2bfbc26a9e4 644 SUPERFAMILY SSF161098 450 633 7.33E-32 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25205 8762d5a42b2749b8cdc4f2bfbc26a9e4 644 Gene3D G3DSA:1.10.3720.10 128 310 4.3E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25205 8762d5a42b2749b8cdc4f2bfbc26a9e4 644 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 152 308 1.2E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25205 8762d5a42b2749b8cdc4f2bfbc26a9e4 644 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 472 625 1.4E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25205 8762d5a42b2749b8cdc4f2bfbc26a9e4 644 SUPERFAMILY SSF161098 128 310 3.92E-32 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25205 8762d5a42b2749b8cdc4f2bfbc26a9e4 644 Gene3D G3DSA:1.10.3720.10 418 633 1.3E-30 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06575 199b99527b034bca27b828eadd7d2879 283 Gene3D G3DSA:3.30.1490.20 99 170 2.3E-7 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS06575 199b99527b034bca27b828eadd7d2879 283 Gene3D G3DSA:3.40.50.20 51 98 2.7E-9 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS06575 199b99527b034bca27b828eadd7d2879 283 SUPERFAMILY SSF56059 85 262 6.13E-16 T 17-03-2017 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 Gene3D G3DSA:1.10.10.10 1 85 1.6E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 SUPERFAMILY SSF46785 1 87 1.12E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 3 61 1.4E-21 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 Gene3D G3DSA:3.40.190.10 176 264 2.4E-19 T 17-03-2017 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 Pfam PF03466 LysR substrate binding domain 88 290 8.2E-30 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 Gene3D G3DSA:3.40.190.10 88 175 5.7E-20 T 17-03-2017 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 SUPERFAMILY SSF53850 88 293 2.02E-27 T 17-03-2017 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 29 39 7.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 50 7.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS00515 106c8b38711e8908bc4d343e4b5c9629 314 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 18 29 7.3E-10 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28565 fd2f79adb4907c91b8abc293782c9361 368 Gene3D G3DSA:3.60.10.10 145 362 2.6E-15 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS28565 fd2f79adb4907c91b8abc293782c9361 368 SUPERFAMILY SSF56219 145 362 8.24E-30 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS28565 fd2f79adb4907c91b8abc293782c9361 368 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 149 354 1.9E-21 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 Gene3D G3DSA:3.40.50.720 140 292 7.8E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 Gene3D G3DSA:3.90.180.10 4 139 2.4E-19 T 17-03-2017 IPR011032 GroES-like SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 SUPERFAMILY SSF51735 118 285 3.49E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 SMART SM00829 12 329 8.2E-4 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 SUPERFAMILY SSF50129 2 164 8.37E-26 T 17-03-2017 IPR011032 GroES-like SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 31 94 6.5E-5 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS32865 f8e104621306fe8dfec47e7904880bbd 335 Pfam PF00107 Zinc-binding dehydrogenase 177 279 9.7E-11 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS42750 e7241e8585b4e905e44e2ad6ab795635 359 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 4 341 4.3E-76 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS42750 e7241e8585b4e905e44e2ad6ab795635 359 SUPERFAMILY SSF51395 1 351 1.18E-120 T 17-03-2017 SHXM_RS42750 e7241e8585b4e905e44e2ad6ab795635 359 Gene3D G3DSA:3.20.20.70 1 355 7.2E-136 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS36075 38a7cce0ea2887a465e0caba0ac6993a 338 SUPERFAMILY SSF51726 60 334 1.44E-30 T 17-03-2017 SHXM_RS36075 38a7cce0ea2887a465e0caba0ac6993a 338 Gene3D G3DSA:3.20.20.210 90 333 3.7E-12 T 17-03-2017 SHXM_RS36075 38a7cce0ea2887a465e0caba0ac6993a 338 Pfam PF01717 Cobalamin-independent synthase, Catalytic domain 18 331 3.4E-15 T 17-03-2017 IPR002629 Cobalamin-independent methionine synthase MetE, C-terminal/archaeal GO:0003871|GO:0008270|GO:0009086 KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS25725 ba53374e1070086e19d87eaba99f0689 273 Gene3D G3DSA:3.40.50.1580 1 261 7.9E-47 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS25725 ba53374e1070086e19d87eaba99f0689 273 Pfam PF01048 Phosphorylase superfamily 102 243 1.7E-6 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS25725 ba53374e1070086e19d87eaba99f0689 273 TIGRFAM TIGR03664 fut_nucase: futalosine hydrolase 121 254 2.2E-44 T 17-03-2017 IPR019963 Futalosine hydrolase GO:0009234|GO:0016799 KEGG: 00130+3.2.2.26|MetaCyc: PWY-7374 SHXM_RS25725 ba53374e1070086e19d87eaba99f0689 273 SUPERFAMILY SSF53167 50 242 3.2E-18 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS25725 ba53374e1070086e19d87eaba99f0689 273 Hamap MF_00991 Futalosine hydrolase [mqnB]. 16 259 25.297 T 17-03-2017 IPR019963 Futalosine hydrolase GO:0009234|GO:0016799 KEGG: 00130+3.2.2.26|MetaCyc: PWY-7374 SHXM_RS04845 1378cbc31bf24ad1850521ce42a77d9f 251 Gene3D G3DSA:2.60.200.20 35 76 0.001 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS04845 1378cbc31bf24ad1850521ce42a77d9f 251 SUPERFAMILY SSF49879 28 79 6.91E-6 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS37740 30570ad5319e96ba336633d2a6c3b868 83 SUPERFAMILY SSF47336 6 80 8.11E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37740 30570ad5319e96ba336633d2a6c3b868 83 Pfam PF00550 Phosphopantetheine attachment site 10 71 2.0E-11 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS37740 30570ad5319e96ba336633d2a6c3b868 83 Gene3D G3DSA:1.10.1200.10 6 78 1.1E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 Pfam PF00725 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 189 285 2.4E-31 T 17-03-2017 IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 SUPERFAMILY SSF51735 4 186 4.96E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 Pfam PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 7 186 4.4E-59 T 17-03-2017 IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding GO:0003857|GO:0006631|GO:0016491|GO:0055114 KEGG: 00062+4.2.1.17+1.1.1.35|KEGG: 00071+4.2.1.17+1.1.1.35|KEGG: 00120+1.1.1.35|KEGG: 00280+4.2.1.17+1.1.1.35|KEGG: 00281+4.2.1.17+1.1.1.35|KEGG: 00310+4.2.1.17+1.1.1.35|KEGG: 00360+4.2.1.17|KEGG: 00362+4.2.1.17+1.1.1.35|KEGG: 00380+4.2.1.17+1.1.1.35|KEGG: 00410+4.2.1.17|KEGG: 00592+4.2.1.17|KEGG: 00623+1.1.1.35|KEGG: 00627+4.2.1.17|KEGG: 00640+4.2.1.17|KEGG: 00650+4.2.1.17+1.1.1.35|KEGG: 00720+4.2.1.17+1.1.1.35|KEGG: 00903+4.2.1.17|KEGG: 00930+4.2.1.17+1.1.1.35|MetaCyc: PWY-1361|MetaCyc: PWY-5109|MetaCyc: PWY-5136|MetaCyc: PWY-5138|MetaCyc: PWY-5177|MetaCyc: PWY-5789|MetaCyc: PWY-6435|MetaCyc: PWY-6583|MetaCyc: PWY-6863|MetaCyc: PWY-6883|MetaCyc: PWY-6944|MetaCyc: PWY-6945|MetaCyc: PWY-6946|MetaCyc: PWY-7007|MetaCyc: PWY-7046|MetaCyc: PWY-7094|MetaCyc: PWY-7216|MetaCyc: PWY-735|MetaCyc: PWY-7401|MetaCyc: PWY-7606|MetaCyc: PWY-7726 SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 SUPERFAMILY SSF48179 189 285 7.99E-29 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 PIRSF PIRSF000105 2 285 5.4E-77 T 17-03-2017 IPR022694 3-hydroxyacyl-CoA dehydrogenase GO:0003857|GO:0006631|GO:0055114|GO:0070403 SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 Gene3D G3DSA:3.40.50.720 2 190 4.6E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13065 ebf9ba73e87c29e4c100504f13dd0c24 285 Gene3D G3DSA:1.10.1040.10 191 285 2.2E-32 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS48240 37d2b25f00359dfcad733e2791777c2e 352 Pfam PF05853 beta-keto acid cleavage enzyme 15 317 1.0E-63 T 17-03-2017 IPR008567 3-keto-5-aminohexanoate cleavage enzyme GO:0016740|GO:0019475 KEGG: 00600+2.3.1.24 SHXM_RS48240 37d2b25f00359dfcad733e2791777c2e 352 Gene3D G3DSA:3.20.20.70 14 319 2.8E-79 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS30485 d27c99b2a904426f0d4bfcc1277091cc 202 Pfam PF13560 Helix-turn-helix domain 34 104 6.2E-8 T 17-03-2017 SHXM_RS30485 d27c99b2a904426f0d4bfcc1277091cc 202 Gene3D G3DSA:1.10.260.40 35 68 4.1E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30485 d27c99b2a904426f0d4bfcc1277091cc 202 SUPERFAMILY SSF47413 34 70 1.2E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00275 6907bdd436d379bc738c50dc870d9666 244 Pfam PF14016 Protein of unknown function (DUF4232) 104 225 4.2E-14 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS24360 e8230cf6af592f6e461bc68e053d813a 172 Pfam PF13581 Histidine kinase-like ATPase domain 51 165 4.5E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24360 e8230cf6af592f6e461bc68e053d813a 172 Gene3D G3DSA:3.30.565.10 68 168 4.9E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24360 e8230cf6af592f6e461bc68e053d813a 172 SUPERFAMILY SSF55874 76 168 3.41E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29665 2cba46986f6dc43e344286efc7bc3f9c 200 PRINTS PR01217 Proline rich extensin signature 173 198 5.7E-11 T 17-03-2017 SHXM_RS29665 2cba46986f6dc43e344286efc7bc3f9c 200 PRINTS PR01217 Proline rich extensin signature 153 170 5.7E-11 T 17-03-2017 SHXM_RS29665 2cba46986f6dc43e344286efc7bc3f9c 200 PRINTS PR01217 Proline rich extensin signature 18 34 5.7E-11 T 17-03-2017 SHXM_RS29665 2cba46986f6dc43e344286efc7bc3f9c 200 PRINTS PR01217 Proline rich extensin signature 123 139 5.7E-11 T 17-03-2017 SHXM_RS16725 09eb13c82b3f1ee5c4cfba191cdf38b4 152 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 34 151 6.5E-20 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16725 09eb13c82b3f1ee5c4cfba191cdf38b4 152 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 1 31 4.0E-7 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS16725 09eb13c82b3f1ee5c4cfba191cdf38b4 152 Gene3D G3DSA:3.40.47.10 1 83 3.1E-25 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16725 09eb13c82b3f1ee5c4cfba191cdf38b4 152 SUPERFAMILY SSF53901 1 81 4.08E-19 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS11000 c2e3d7cb7a18f4b83192d8a9ccb22ee0 131 Pfam PF04341 Protein of unknown function, DUF485 37 123 1.3E-28 T 17-03-2017 IPR007436 Protein of unknown function DUF485 SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 SUPERFAMILY SSF53901 185 379 2.35E-49 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 Pfam PF02801 Beta-ketoacyl synthase, C-terminal domain 223 334 5.5E-27 T 17-03-2017 IPR014031 Beta-ketoacyl synthase, C-terminal SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 Gene3D G3DSA:3.40.47.10 230 379 1.5E-43 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 SMART SM00825 Beta-ketoacyl synthase 9 381 2.0E-11 T 17-03-2017 IPR020841 Polyketide synthase, beta-ketoacyl synthase domain SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 SUPERFAMILY SSF53901 5 215 1.93E-32 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 5 214 1.9E-17 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS23120 555d1efccb9a797be2b40721aff993ad 381 Gene3D G3DSA:3.40.47.10 5 215 5.0E-26 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Gene3D G3DSA:1.10.510.10 83 275 5.7E-50 T 17-03-2017 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 17 40 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Pfam PF00069 Protein kinase domain 11 225 1.3E-47 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Pfam PF13374 Tetratricopeptide repeat 659 700 7.9E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Pfam PF13374 Tetratricopeptide repeat 617 658 4.7E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Pfam PF13374 Tetratricopeptide repeat 533 574 1.0E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Gene3D G3DSA:3.30.200.20 6 82 2.8E-23 T 17-03-2017 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 SUPERFAMILY SSF48452 372 434 6.45E-6 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Pfam PF13424 Tetratricopeptide repeat 457 514 1.6E-9 T 17-03-2017 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Pfam PF13424 Tetratricopeptide repeat 372 434 1.6E-7 T 17-03-2017 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Gene3D G3DSA:1.25.40.10 376 466 2.9E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 Gene3D G3DSA:1.25.40.10 467 704 2.1E-23 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 SMART SM00220 11 279 4.1E-64 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 SUPERFAMILY SSF56112 4 292 4.72E-77 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 SUPERFAMILY SSF48452 570 717 6.45E-19 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS43565 fa9b8f24f0c59375e2613f4baf9e3c1c 719 SUPERFAMILY SSF48452 444 561 6.79E-15 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 Gene3D G3DSA:1.10.10.10 5 100 2.3E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 Pfam PF01022 Bacterial regulatory protein, arsR family 11 55 3.8E-16 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 SUPERFAMILY SSF46785 5 96 5.3E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 SMART SM00418 3 81 1.2E-23 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 5 20 4.5E-12 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 37 52 4.5E-12 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS36010 3421622f6e6b5be62722e04692e8cc08 127 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 52 67 4.5E-12 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS39290 5e8fa52cb3ded4e612f00fff383c585c 233 SUPERFAMILY SSF53098 50 201 1.12E-16 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS39290 5e8fa52cb3ded4e612f00fff383c585c 233 Pfam PF13683 Integrase core domain 136 199 1.5E-10 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS39290 5e8fa52cb3ded4e612f00fff383c585c 233 Gene3D G3DSA:3.30.420.10 54 203 3.2E-12 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS43505 9447337320325a682ba99788d172ee90 284 Pfam PF00582 Universal stress protein family 3 136 8.9E-12 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43505 9447337320325a682ba99788d172ee90 284 Pfam PF00582 Universal stress protein family 145 282 8.2E-15 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS43505 9447337320325a682ba99788d172ee90 284 Gene3D G3DSA:3.40.50.620 131 282 1.0E-22 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43505 9447337320325a682ba99788d172ee90 284 Gene3D G3DSA:3.40.50.620 4 130 1.0E-21 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43505 9447337320325a682ba99788d172ee90 284 PRINTS PR01438 Universal stress protein signature 242 254 9.9E-7 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43505 9447337320325a682ba99788d172ee90 284 PRINTS PR01438 Universal stress protein signature 2 20 9.9E-7 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43505 9447337320325a682ba99788d172ee90 284 PRINTS PR01438 Universal stress protein signature 260 282 9.9E-7 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS43505 9447337320325a682ba99788d172ee90 284 SUPERFAMILY SSF52402 146 283 6.36E-20 T 17-03-2017 SHXM_RS43505 9447337320325a682ba99788d172ee90 284 SUPERFAMILY SSF52402 6 138 1.84E-16 T 17-03-2017 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 Pfam PF00673 ribosomal L5P family C-terminus 90 183 1.3E-39 T 17-03-2017 IPR031309 Ribosomal protein L5, C-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 Hamap MF_01333_B 50S ribosomal protein L5 [rplE]. 7 185 43.723 T 17-03-2017 IPR020930 Ribosomal protein L5, bacterial-type GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 PIRSF PIRSF002161 3 186 3.0E-65 T 17-03-2017 IPR002132 Ribosomal protein L5 GO:0003735|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 SUPERFAMILY SSF55282 9 184 1.3E-75 T 17-03-2017 IPR022803 Ribosomal protein L5 domain Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 ProSitePatterns PS00358 Ribosomal protein L5 signature. 63 79 - T 17-03-2017 IPR020929 Ribosomal protein L5, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 Gene3D G3DSA:3.30.1440.10 8 184 3.0E-76 T 17-03-2017 IPR022803 Ribosomal protein L5 domain Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS31225 715d1fb0bf0125688c51fe4825367e44 186 Pfam PF00281 Ribosomal protein L5 30 86 6.0E-28 T 17-03-2017 IPR031310 Ribosomal protein L5, N-terminal Reactome: R-HSA-156827|Reactome: R-HSA-156902|Reactome: R-HSA-1799339|Reactome: R-HSA-192823|Reactome: R-HSA-2408557|Reactome: R-HSA-6791226|Reactome: R-HSA-72689|Reactome: R-HSA-72706|Reactome: R-HSA-72764|Reactome: R-HSA-975956|Reactome: R-HSA-975957 SHXM_RS32135 f92f20218bc442a7f630de5f6fca5e79 454 SUPERFAMILY SSF103473 15 440 6.67E-78 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS32135 f92f20218bc442a7f630de5f6fca5e79 454 Gene3D G3DSA:1.20.1250.20 244 439 1.1E-13 T 17-03-2017 SHXM_RS32135 f92f20218bc442a7f630de5f6fca5e79 454 Pfam PF07690 Major Facilitator Superfamily 30 358 6.7E-38 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS32135 f92f20218bc442a7f630de5f6fca5e79 454 Gene3D G3DSA:1.20.1250.20 21 222 6.2E-43 T 17-03-2017 SHXM_RS14770 622d1900c331b8d9e389a27583a23851 92 Gene3D G3DSA:1.10.1220.10 11 53 7.7E-6 T 17-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 SHXM_RS14770 622d1900c331b8d9e389a27583a23851 92 SUPERFAMILY SSF47598 8 54 7.78E-7 T 17-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 9 116 2.8E-18 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 SUPERFAMILY SSF47203 225 377 1.14E-27 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 Gene3D G3DSA:1.10.540.10 9 113 1.9E-22 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 SUPERFAMILY SSF56645 10 223 6.02E-53 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 226 371 2.6E-23 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 Gene3D G3DSA:2.40.110.10 119 214 1.7E-26 T 17-03-2017 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 Gene3D G3DSA:1.20.140.10 215 376 4.0E-32 T 17-03-2017 SHXM_RS50110 35af19c3fb7037fadbcd2b686b0cd39d 383 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 120 214 1.4E-18 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 Pfam PF08028 Acyl-CoA dehydrogenase, C-terminal domain 236 366 4.9E-10 T 17-03-2017 IPR013107 Acyl-CoA dehydrogenase, C-terminal domain SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 SUPERFAMILY SSF56645 10 213 5.1E-32 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 Gene3D G3DSA:1.20.140.10 220 390 9.6E-43 T 17-03-2017 SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 Gene3D G3DSA:1.10.540.10 4 105 2.5E-24 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 Gene3D G3DSA:2.40.110.10 124 213 5.7E-9 T 17-03-2017 SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 18 91 1.5E-8 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS04485 3c8044e579ba58936148f9dce90e7465 392 SUPERFAMILY SSF47203 231 387 1.93E-17 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS09040 d6f538cffa33d4b3c11e6b684c4ce538 211 Gene3D G3DSA:1.10.10.10 137 196 4.7E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 Gene3D G3DSA:1.10.3860.10 16 420 6.5E-101 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 Pfam PF00375 Sodium:dicarboxylate symporter family 22 415 1.6E-104 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 ProSitePatterns PS00714 Sodium:dicarboxylate symporter family signature 2. 309 332 - T 17-03-2017 IPR018107 Sodium:dicarboxylate symporter, conserved site SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 PRINTS PR00173 Glutamate-aspartate symporter signature 341 360 1.6E-20 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 PRINTS PR00173 Glutamate-aspartate symporter signature 20 40 1.6E-20 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 PRINTS PR00173 Glutamate-aspartate symporter signature 87 112 1.6E-20 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 PRINTS PR00173 Glutamate-aspartate symporter signature 306 332 1.6E-20 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 PRINTS PR00173 Glutamate-aspartate symporter signature 206 225 1.6E-20 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS45185 dc99343b4085c722fcada896d1f1daae 479 SUPERFAMILY SSF118215 22 416 5.89E-107 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS17965 d6a72502ee769b49cca7dbcd16eeb926 316 Pfam PF00294 pfkB family carbohydrate kinase 2 309 3.0E-41 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS17965 d6a72502ee769b49cca7dbcd16eeb926 316 Gene3D G3DSA:3.40.1190.20 2 313 3.1E-62 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS17965 d6a72502ee769b49cca7dbcd16eeb926 316 SUPERFAMILY SSF53613 2 311 2.49E-60 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS17965 d6a72502ee769b49cca7dbcd16eeb926 316 ProSitePatterns PS00584 pfkB family of carbohydrate kinases signature 2. 252 265 - T 17-03-2017 IPR002173 Carbohydrate/puine kinase, PfkB, conserved site GO:0016773 SHXM_RS11840 09a9f30dfbebca616ba18f62020ae374 574 Pfam PF13556 PucR C-terminal helix-turn-helix domain 507 565 2.9E-21 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS11840 09a9f30dfbebca616ba18f62020ae374 574 Gene3D G3DSA:1.10.10.60 514 542 1.0E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16225 39cc7cd8c67d343e576bae786b425420 249 SUPERFAMILY SSF102215 12 240 1.09E-57 T 17-03-2017 IPR024087 Creatininase-like domain KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS16225 39cc7cd8c67d343e576bae786b425420 249 Pfam PF02633 Creatinine amidohydrolase 19 239 1.2E-57 T 17-03-2017 IPR003785 Creatininase/formamide hydrolase KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS16225 39cc7cd8c67d343e576bae786b425420 249 Gene3D G3DSA:3.40.50.10310 12 240 3.6E-62 T 17-03-2017 IPR024087 Creatininase-like domain KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|KEGG: 00740+3.5.1.102|MetaCyc: PWY-2201|MetaCyc: PWY-5497|MetaCyc: PWY-6167 SHXM_RS31325 e4ce11a28a4c5217d04653d12999504c 292 Gene3D G3DSA:3.30.750.24 165 258 4.7E-16 T 17-03-2017 IPR002645 STAS domain SHXM_RS31325 e4ce11a28a4c5217d04653d12999504c 292 Pfam PF14361 RsbT co-antagonist protein rsbRD N-terminal domain 13 113 2.5E-16 T 17-03-2017 IPR025751 RsbT co-antagonist protein RsbRD, N-terminal domain SHXM_RS31325 e4ce11a28a4c5217d04653d12999504c 292 SUPERFAMILY SSF52091 165 275 5.1E-19 T 17-03-2017 IPR002645 STAS domain SHXM_RS31325 e4ce11a28a4c5217d04653d12999504c 292 Pfam PF01740 STAS domain 174 271 2.1E-10 T 17-03-2017 IPR002645 STAS domain SHXM_RS03845 4cf3cb7639d2b15b84f66417c8462adc 493 Gene3D G3DSA:1.20.1250.20 264 464 8.2E-12 T 17-03-2017 SHXM_RS03845 4cf3cb7639d2b15b84f66417c8462adc 493 Pfam PF07690 Major Facilitator Superfamily 17 406 1.2E-46 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS03845 4cf3cb7639d2b15b84f66417c8462adc 493 SUPERFAMILY SSF103473 245 473 2.75E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS03845 4cf3cb7639d2b15b84f66417c8462adc 493 SUPERFAMILY SSF103473 6 192 2.75E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS03845 4cf3cb7639d2b15b84f66417c8462adc 493 Gene3D G3DSA:1.20.1250.20 9 193 1.4E-29 T 17-03-2017 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 Pfam PF00532 Periplasmic binding proteins and sugar binding domain of LacI family 74 319 3.7E-29 T 17-03-2017 IPR001761 Periplasmic binding protein/LacI sugar binding domain SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 SUPERFAMILY SSF47413 14 72 7.78E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 SMART SM00354 15 85 6.2E-29 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 SUPERFAMILY SSF53822 75 330 6.21E-54 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 Pfam PF00356 Bacterial regulatory proteins, lacI family 17 62 5.2E-17 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 27 37 8.1E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 PRINTS PR00036 LacI bacterial regulatory protein HTH signature 17 27 8.1E-5 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 Gene3D G3DSA:3.40.50.2300 65 187 3.3E-39 T 17-03-2017 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 Gene3D G3DSA:1.10.260.40 14 64 1.2E-22 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS02815 0af3d85d0dc0ca1391c7c7fa7daebf11 344 Gene3D G3DSA:3.40.50.2300 188 315 4.5E-36 T 17-03-2017 SHXM_RS28655 6798a03cfe4706bbe10c6f095dd99311 376 SUPERFAMILY SSF53335 118 205 1.4E-17 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS28655 6798a03cfe4706bbe10c6f095dd99311 376 Gene3D G3DSA:3.40.50.150 19 219 4.1E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS28655 6798a03cfe4706bbe10c6f095dd99311 376 Pfam PF13649 Methyltransferase domain 118 197 1.0E-6 T 17-03-2017 SHXM_RS21460 88da44ede1de6e4997039ccb7d707f0e 98 Pfam PF13751 Transposase DDE domain 5 72 6.8E-15 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS02005 401b6a394adf0ce67bf820d393ff4b76 288 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 110 279 1.2E-26 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02005 401b6a394adf0ce67bf820d393ff4b76 288 Gene3D G3DSA:1.10.3720.10 85 279 6.5E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02005 401b6a394adf0ce67bf820d393ff4b76 288 SUPERFAMILY SSF161098 85 267 2.09E-31 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04130 bc85b3077b59d6a8b793fdc676e35759 149 Gene3D G3DSA:3.30.530.20 4 124 2.9E-12 T 17-03-2017 IPR023393 START-like domain SHXM_RS04130 bc85b3077b59d6a8b793fdc676e35759 149 SUPERFAMILY SSF55961 3 132 1.94E-13 T 17-03-2017 SHXM_RS47140 bf4c58f7530f8c17c4524e98720821f9 255 Gene3D G3DSA:3.90.226.10 6 221 1.1E-54 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47140 bf4c58f7530f8c17c4524e98720821f9 255 SUPERFAMILY SSF52096 6 233 1.61E-56 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47140 bf4c58f7530f8c17c4524e98720821f9 255 Pfam PF00378 Enoyl-CoA hydratase/isomerase 7 209 2.4E-39 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS04775 b1a1da543a3131328708a5f3ebd39b63 163 SUPERFAMILY SSF50475 20 153 7.65E-15 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS04775 b1a1da543a3131328708a5f3ebd39b63 163 Gene3D G3DSA:2.30.110.10 20 113 9.0E-12 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18195 bf4739489ff3deada6a8dc2038d70c94 247 Pfam PF04402 Protein of unknown function (DUF541) 32 240 1.8E-33 T 17-03-2017 IPR007497 Protein of unknown function DUF541 SHXM_RS18270 9901dde353184926c0497069fd4e1e6e 310 Gene3D G3DSA:3.40.50.300 9 225 1.3E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18270 9901dde353184926c0497069fd4e1e6e 310 SUPERFAMILY SSF52540 11 225 3.55E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18270 9901dde353184926c0497069fd4e1e6e 310 Pfam PF00005 ABC transporter 26 162 2.9E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS18270 9901dde353184926c0497069fd4e1e6e 310 SMART SM00382 35 219 1.6E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS18270 9901dde353184926c0497069fd4e1e6e 310 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS38900 9fb29f97a465efaa731bd810c0d797cc 546 Pfam PF00295 Glycosyl hydrolases family 28 206 521 7.8E-12 T 17-03-2017 IPR000743 Glycoside hydrolase, family 28 GO:0004650|GO:0005975 SHXM_RS38900 9fb29f97a465efaa731bd810c0d797cc 546 SMART SM00710 480 502 69.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS38900 9fb29f97a465efaa731bd810c0d797cc 546 SMART SM00710 415 436 770.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS38900 9fb29f97a465efaa731bd810c0d797cc 546 SMART SM00710 322 348 1500.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS38900 9fb29f97a465efaa731bd810c0d797cc 546 SUPERFAMILY SSF51126 171 518 5.37E-47 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS38900 9fb29f97a465efaa731bd810c0d797cc 546 Gene3D G3DSA:2.160.20.10 156 524 4.2E-48 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS31915 e051d5c912e26efc62c053512a63da14 69 Pfam PF04149 Domain of unknown function (DUF397) 10 61 2.4E-21 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS28930 fb6fda59d37a3430a7309c141f0d9225 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 65 87 3.6E-6 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS28930 fb6fda59d37a3430a7309c141f0d9225 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 112 137 3.6E-6 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS28930 fb6fda59d37a3430a7309c141f0d9225 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 205 224 3.6E-6 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS28930 fb6fda59d37a3430a7309c141f0d9225 263 PRINTS PR00164 ABC-2 type transport system membrane protein signature 185 204 3.6E-6 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS28930 fb6fda59d37a3430a7309c141f0d9225 263 Pfam PF01061 ABC-2 type transporter 13 227 1.1E-28 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS28930 fb6fda59d37a3430a7309c141f0d9225 263 PIRSF PIRSF006648 1 263 3.2E-66 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 10 34 4.3E-10 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 394 413 4.3E-10 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 295 319 4.3E-10 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 131 155 4.3E-10 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 PRINTS PR01036 Tetracycline resistance protein TetB signature 101 121 4.3E-10 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 SUPERFAMILY SSF103473 2 190 6.8E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 SUPERFAMILY SSF103473 467 492 6.8E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 SUPERFAMILY SSF103473 241 413 6.8E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 Pfam PF07690 Major Facilitator Superfamily 12 403 3.2E-53 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 Gene3D G3DSA:1.20.1250.20 256 413 1.1E-25 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 Gene3D G3DSA:1.20.1250.20 6 185 2.5E-29 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 Gene3D G3DSA:1.20.1250.20 468 494 1.1E-25 T 17-03-2017 SHXM_RS27705 c8219eab44b052cbd12902f6f620891d 514 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 10 484 1.2E-76 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS39735 a4d8a8392a632a93b7109acc146cce34 280 Pfam PF08450 SMP-30/Gluconolaconase/LRE-like region 10 248 5.7E-32 T 17-03-2017 IPR013658 SMP-30/Gluconolactonase/LRE-like region SHXM_RS39735 a4d8a8392a632a93b7109acc146cce34 280 Gene3D G3DSA:2.120.10.30 5 251 2.7E-36 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS39735 a4d8a8392a632a93b7109acc146cce34 280 SUPERFAMILY SSF63829 3 251 2.11E-33 T 17-03-2017 SHXM_RS02080 1cd51b3af96010af03aa427bd3d29a94 136 Gene3D G3DSA:3.30.1330.40 6 130 2.9E-38 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS02080 1cd51b3af96010af03aa427bd3d29a94 136 Pfam PF01042 Endoribonuclease L-PSP 15 128 2.6E-26 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS02080 1cd51b3af96010af03aa427bd3d29a94 136 SUPERFAMILY SSF55298 6 129 5.03E-36 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS07710 e2673c3e5efa0dc6c7646cf7248e1f36 89 ProDom PD280340 RV1738/MT1780 MB2665C MB1767 SCO3163 RV2632C/MT2708 1 78 6.0E-8 T 17-03-2017 IPR015057 Protein of unknown function DUF1876 SHXM_RS07710 e2673c3e5efa0dc6c7646cf7248e1f36 89 SUPERFAMILY SSF143212 3 83 2.22E-21 T 17-03-2017 SHXM_RS07710 e2673c3e5efa0dc6c7646cf7248e1f36 89 Pfam PF08962 Domain of unknown function (DUF1876) 7 86 1.3E-28 T 17-03-2017 IPR015057 Protein of unknown function DUF1876 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 Pfam PF01266 FAD dependent oxidoreductase 35 388 2.2E-45 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 SUPERFAMILY SSF51905 33 285 8.12E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 SUPERFAMILY SSF51905 381 395 8.12E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 Gene3D G3DSA:3.50.50.60 32 275 3.4E-43 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 Pfam PF16901 C-terminal domain of alpha-glycerophosphate oxidase 421 534 7.1E-14 T 17-03-2017 IPR031656 Alpha-glycerophosphate oxidase, C-terminal KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 34 46 2.1E-19 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 349 355 2.1E-19 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 109 121 2.1E-19 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 63 75 2.1E-19 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS16000 39c060f9d746cc6bd10ab4aceaef25fe 536 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 378 390 2.1E-19 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS07650 e822fb983335d221c1d152e6a5565a74 186 Pfam PF12587 Protein of unknown function (DUF3761) 146 183 9.9E-11 T 17-03-2017 IPR022236 Protein of unknown function DUF3761 SHXM_RS39755 57bfbd593a5c05fa06d31d3f8a675d98 372 Gene3D G3DSA:3.10.310.10 176 343 5.2E-49 T 17-03-2017 SHXM_RS39755 57bfbd593a5c05fa06d31d3f8a675d98 372 Gene3D G3DSA:3.10.310.10 4 175 4.7E-57 T 17-03-2017 SHXM_RS39755 57bfbd593a5c05fa06d31d3f8a675d98 372 SUPERFAMILY SSF54506 3 167 8.37E-47 T 17-03-2017 SHXM_RS39755 57bfbd593a5c05fa06d31d3f8a675d98 372 SUPERFAMILY SSF54506 171 365 7.22E-46 T 17-03-2017 SHXM_RS39755 57bfbd593a5c05fa06d31d3f8a675d98 372 Pfam PF04303 PrpF protein 3 362 8.2E-91 T 17-03-2017 IPR007400 PrpF protein SHXM_RS08275 4e36abc3ea2945cea8a07712c2b22fdc 198 Pfam PF00730 HhH-GPD superfamily base excision DNA repair protein 26 191 3.3E-9 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS08275 4e36abc3ea2945cea8a07712c2b22fdc 198 SUPERFAMILY SSF48150 13 142 1.96E-10 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS08275 4e36abc3ea2945cea8a07712c2b22fdc 198 Gene3D G3DSA:1.10.340.30 17 137 6.0E-8 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS08275 4e36abc3ea2945cea8a07712c2b22fdc 198 TIGRFAM TIGR03252 TIGR03252: uncharacterized HhH-GPD family protein 5 192 6.2E-91 T 17-03-2017 IPR017658 Conserved hypothetical protein CHP03252, HhH-GPD SHXM_RS45755 c9975f3b7178cec9e4e210cdb85e4065 405 SUPERFAMILY SSF46785 21 80 4.31E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45755 c9975f3b7178cec9e4e210cdb85e4065 405 SUPERFAMILY SSF53067 89 390 5.99E-44 T 17-03-2017 SHXM_RS45755 c9975f3b7178cec9e4e210cdb85e4065 405 Pfam PF00480 ROK family 99 390 3.4E-43 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS45755 c9975f3b7178cec9e4e210cdb85e4065 405 Gene3D G3DSA:3.30.420.40 229 372 1.0E-34 T 17-03-2017 SHXM_RS45755 c9975f3b7178cec9e4e210cdb85e4065 405 Gene3D G3DSA:3.30.420.40 83 228 6.3E-36 T 17-03-2017 SHXM_RS45755 c9975f3b7178cec9e4e210cdb85e4065 405 Gene3D G3DSA:1.10.10.10 22 82 4.1E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20380 558b0fc966a9c46010253e30474b6c62 369 Gene3D G3DSA:3.40.50.2300 43 157 1.2E-30 T 17-03-2017 SHXM_RS20380 558b0fc966a9c46010253e30474b6c62 369 Gene3D G3DSA:3.40.50.2300 158 355 5.0E-38 T 17-03-2017 SHXM_RS20380 558b0fc966a9c46010253e30474b6c62 369 SUPERFAMILY SSF53822 42 355 1.57E-69 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS20380 558b0fc966a9c46010253e30474b6c62 369 Pfam PF13407 Periplasmic binding protein domain 45 322 6.7E-67 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS50445 0d8245729a375f975c6cd0ae05dc59fc 206 Pfam PF13358 DDE superfamily endonuclease 15 159 3.3E-20 T 17-03-2017 SHXM_RS29180 0d8245729a375f975c6cd0ae05dc59fc 206 Pfam PF13358 DDE superfamily endonuclease 15 159 3.3E-20 T 17-03-2017 SHXM_RS26430 6fddccddb4459580ccc6e68e2dbfc939 119 Gene3D G3DSA:3.30.1130.10 2 118 8.9E-45 T 17-03-2017 SHXM_RS26430 6fddccddb4459580ccc6e68e2dbfc939 119 SUPERFAMILY SSF55620 2 118 1.72E-36 T 17-03-2017 SHXM_RS26430 6fddccddb4459580ccc6e68e2dbfc939 119 SMART SM00905 4 116 1.6E-47 T 17-03-2017 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26430 6fddccddb4459580ccc6e68e2dbfc939 119 TIGRFAM TIGR00525 folB: dihydroneopterin aldolase 2 116 6.6E-35 T 17-03-2017 IPR006156 Dihydroneopterin aldolase GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26430 6fddccddb4459580ccc6e68e2dbfc939 119 TIGRFAM TIGR00526 folB_dom: FolB domain 2 118 1.8E-30 T 17-03-2017 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS26430 6fddccddb4459580ccc6e68e2dbfc939 119 Pfam PF02152 Dihydroneopterin aldolase 5 115 2.8E-35 T 17-03-2017 IPR006157 Dihydroneopterin aldolase/epimerase domain GO:0004150|GO:0006760 KEGG: 00790+4.1.2.25|MetaCyc: PWY-6147|MetaCyc: PWY-6148|MetaCyc: PWY-6797|MetaCyc: PWY-7539 SHXM_RS13580 ffe435cec1370b67fdee864055eaf9a3 226 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 8 203 1.6E-34 T 17-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 SHXM_RS13580 ffe435cec1370b67fdee864055eaf9a3 226 Gene3D G3DSA:1.10.3630.10 3 216 1.1E-21 T 17-03-2017 SHXM_RS45025 1f0346014c2d4f20842966f8d33e39f6 407 PIRSF PIRSF017901 1 406 6.5E-116 T 17-03-2017 SHXM_RS45025 1f0346014c2d4f20842966f8d33e39f6 407 Pfam PF04107 Glutamate-cysteine ligase family 2(GCS2) 19 322 1.7E-75 T 17-03-2017 IPR006336 Glutamate--cysteine ligase, GCS2 GO:0004357|GO:0042398 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 SHXM_RS45025 1f0346014c2d4f20842966f8d33e39f6 407 TIGRFAM TIGR03444 EgtA_Cys_ligase: ergothioneine biosynthesis glutamate--cysteine ligase EgtA 6 395 2.0E-135 T 17-03-2017 IPR017809 Glutamate--cysteine ligase EgtA, Actinobacteria GO:0004357|GO:0052699 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 SHXM_RS45025 1f0346014c2d4f20842966f8d33e39f6 407 SUPERFAMILY SSF55931 10 235 1.47E-37 T 17-03-2017 SHXM_RS45025 1f0346014c2d4f20842966f8d33e39f6 407 SUPERFAMILY SSF55931 271 398 1.47E-37 T 17-03-2017 SHXM_RS45025 1f0346014c2d4f20842966f8d33e39f6 407 Hamap MF_02034 Glutamate--cysteine ligase EgtA [egtA]. 1 393 31.345 T 17-03-2017 IPR017809 Glutamate--cysteine ligase EgtA, Actinobacteria GO:0004357|GO:0052699 KEGG: 00270+6.3.2.2|KEGG: 00480+6.3.2.2|MetaCyc: PWY-6840|MetaCyc: PWY-7255 SHXM_RS15785 09c30d43aa57358150d34961a5d88d32 233 SUPERFAMILY SSF52518 31 228 2.43E-45 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS15785 09c30d43aa57358150d34961a5d88d32 233 Gene3D G3DSA:3.40.50.970 31 228 3.2E-45 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS15785 09c30d43aa57358150d34961a5d88d32 233 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 28 215 9.9E-25 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS41000 26f7bbcc291cc08e3d50e01b9549940f 314 Pfam PF00480 ROK family 195 311 1.9E-6 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS41000 26f7bbcc291cc08e3d50e01b9549940f 314 Gene3D G3DSA:3.30.420.40 161 285 1.1E-16 T 17-03-2017 SHXM_RS41000 26f7bbcc291cc08e3d50e01b9549940f 314 Gene3D G3DSA:3.30.420.40 18 160 1.2E-17 T 17-03-2017 SHXM_RS41000 26f7bbcc291cc08e3d50e01b9549940f 314 SUPERFAMILY SSF53067 18 312 1.46E-22 T 17-03-2017 SHXM_RS23410 a1716796478bfd2910ab9d2058b24fee 92 SUPERFAMILY SSF54285 1 90 2.47E-25 T 17-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp SHXM_RS23410 a1716796478bfd2910ab9d2058b24fee 92 Pfam PF02597 ThiS family 5 90 4.0E-19 T 17-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 SHXM_RS23410 a1716796478bfd2910ab9d2058b24fee 92 Gene3D G3DSA:3.10.20.30 3 88 4.3E-31 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS01460 6711c6b789df1ee5b2acc66ccd45200f 97 Pfam PF01266 FAD dependent oxidoreductase 12 43 1.8E-6 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS01460 6711c6b789df1ee5b2acc66ccd45200f 97 Gene3D G3DSA:3.50.50.60 12 56 7.1E-10 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01460 6711c6b789df1ee5b2acc66ccd45200f 97 SUPERFAMILY SSF51905 11 84 3.88E-10 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS00555 0f8c32307237eeab6879fe5e2d4c19b6 305 Gene3D G3DSA:3.20.20.140 1 153 3.9E-12 T 17-03-2017 SHXM_RS00555 0f8c32307237eeab6879fe5e2d4c19b6 305 SUPERFAMILY SSF89550 1 204 9.03E-28 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS13975 b5d9c490bc29c401aa95820221fc62ae 446 Gene3D G3DSA:3.40.190.10 169 335 6.7E-31 T 17-03-2017 SHXM_RS13975 b5d9c490bc29c401aa95820221fc62ae 446 SUPERFAMILY SSF53850 54 435 1.8E-68 T 17-03-2017 SHXM_RS13975 b5d9c490bc29c401aa95820221fc62ae 446 Gene3D G3DSA:3.40.190.10 9 162 4.9E-23 T 17-03-2017 SHXM_RS13975 b5d9c490bc29c401aa95820221fc62ae 446 Gene3D G3DSA:3.40.190.10 336 370 4.9E-23 T 17-03-2017 SHXM_RS13975 b5d9c490bc29c401aa95820221fc62ae 446 Pfam PF01547 Bacterial extracellular solute-binding protein 65 345 8.8E-36 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS35455 f0904899b23ad1291fad30ba2bb285ec 114 Pfam PF12823 Domain of unknown function (DUF3817) 9 95 5.2E-23 T 17-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane SHXM_RS35455 f0904899b23ad1291fad30ba2bb285ec 114 TIGRFAM TIGR03954 integ_memb_HG: integral membrane protein 13 94 3.4E-23 T 17-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane SHXM_RS15500 00748a8657c541632ba42a57977d4bde 338 PRINTS PR00108 Thymidylate synthase family signature 120 139 3.8E-5 T 17-03-2017 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS15500 00748a8657c541632ba42a57977d4bde 338 PRINTS PR00108 Thymidylate synthase family signature 166 192 3.8E-5 T 17-03-2017 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS15500 00748a8657c541632ba42a57977d4bde 338 PRINTS PR00108 Thymidylate synthase family signature 204 221 3.8E-5 T 17-03-2017 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS15500 00748a8657c541632ba42a57977d4bde 338 Pfam PF00303 Thymidylate synthase 10 229 2.6E-17 T 17-03-2017 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS15500 00748a8657c541632ba42a57977d4bde 338 SUPERFAMILY SSF55831 5 229 4.32E-48 T 17-03-2017 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS15500 00748a8657c541632ba42a57977d4bde 338 Gene3D G3DSA:3.30.572.10 5 231 9.9E-45 T 17-03-2017 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 Gene3D G3DSA:3.90.45.10 20 187 8.3E-52 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 Pfam PF01327 Polypeptide deformylase 21 180 1.9E-42 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 Hamap MF_00163 Peptide deformylase [def]. 18 186 25.199 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 SUPERFAMILY SSF56420 18 180 3.53E-48 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 PRINTS PR01576 Peptide deformylase signature 151 180 1.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 PRINTS PR01576 Peptide deformylase signature 120 131 1.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 PRINTS PR01576 Peptide deformylase signature 132 150 1.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS08075 b45f8ddd0f541c302351b8f1ad638cb5 227 PRINTS PR01576 Peptide deformylase signature 51 80 1.9E-33 T 17-03-2017 IPR023635 Peptide deformylase SHXM_RS37780 6263e61487d19a778d97e519a9fff4ed 134 Pfam PF07977 FabA-like domain 35 103 1.0E-5 T 17-03-2017 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS37780 6263e61487d19a778d97e519a9fff4ed 134 Gene3D G3DSA:3.10.129.10 27 126 1.1E-17 T 17-03-2017 IPR029069 HotDog domain SHXM_RS37780 6263e61487d19a778d97e519a9fff4ed 134 SUPERFAMILY SSF54637 27 112 1.07E-17 T 17-03-2017 IPR029069 HotDog domain SHXM_RS46730 e1356a7d8da3eae18721255c2bd49fc4 291 Gene3D G3DSA:3.40.50.300 15 249 2.6E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46730 e1356a7d8da3eae18721255c2bd49fc4 291 Pfam PF00005 ABC transporter 35 182 4.4E-31 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46730 e1356a7d8da3eae18721255c2bd49fc4 291 ProSitePatterns PS00211 ABC transporters family signature. 155 169 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS46730 e1356a7d8da3eae18721255c2bd49fc4 291 SUPERFAMILY SSF52540 17 243 4.35E-62 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46730 e1356a7d8da3eae18721255c2bd49fc4 291 SMART SM00382 43 231 3.9E-18 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS01695 05b4cdaa3732204fb5eab8537eee3159 349 Pfam PF00296 Luciferase-like monooxygenase 22 302 1.1E-47 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01695 05b4cdaa3732204fb5eab8537eee3159 349 SUPERFAMILY SSF51679 22 340 1.31E-71 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01695 05b4cdaa3732204fb5eab8537eee3159 349 Gene3D G3DSA:3.20.20.30 7 343 4.3E-80 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS42135 679f2f1b54650bf37a6671da817affce 174 Pfam PF13581 Histidine kinase-like ATPase domain 43 154 2.4E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42135 679f2f1b54650bf37a6671da817affce 174 SUPERFAMILY SSF55874 68 161 2.41E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 Pfam PF00034 Cytochrome c 50 125 3.4E-8 T 17-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 Pfam PF13442 Cytochrome C oxidase, cbb3-type, subunit III 142 216 6.1E-11 T 17-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 SUPERFAMILY SSF46626 13 130 2.58E-18 T 17-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 SUPERFAMILY SSF46626 124 218 7.71E-25 T 17-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 Gene3D G3DSA:1.10.760.10 142 223 9.7E-18 T 17-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 PIRSF PIRSF000007 1 263 2.3E-118 T 17-03-2017 IPR009152 Ubiquinol-cytochrome-c reductase, cytochrome c subunit GO:0005506|GO:0009055|GO:0016021|GO:0020037 SHXM_RS18880 eec0d2372c8b7ba2b562b46299ae3344 269 Gene3D G3DSA:1.10.760.10 48 133 1.1E-17 T 17-03-2017 IPR009056 Cytochrome c-like domain GO:0009055|GO:0020037 Reactome: R-HSA-611105 SHXM_RS30220 8a56fcbcfdf5af09bc173d8af1e6f70f 144 Gene3D G3DSA:3.30.565.10 46 136 6.3E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30220 8a56fcbcfdf5af09bc173d8af1e6f70f 144 Pfam PF13581 Histidine kinase-like ATPase domain 24 130 4.2E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS30220 8a56fcbcfdf5af09bc173d8af1e6f70f 144 SUPERFAMILY SSF55874 45 133 7.31E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS12170 ef9c9c1ebcbb78be602735ea58c34176 434 Gene3D G3DSA:1.50.10.110 75 424 1.4E-97 T 17-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SHXM_RS12170 ef9c9c1ebcbb78be602735ea58c34176 434 SUPERFAMILY SSF48230 94 379 4.67E-57 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS12170 ef9c9c1ebcbb78be602735ea58c34176 434 Pfam PF05426 Alginate lyase 92 376 2.7E-91 T 17-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 86 97 2.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 139 147 2.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 159 178 2.6E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 146 174 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 7.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 180 197 7.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 159 178 7.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 7.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 133 149 7.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 86 97 7.2E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 Gene3D G3DSA:3.40.50.720 10 254 2.6E-78 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 22 253 1.2E-65 T 17-03-2017 SHXM_RS02605 ec0d276932a76ac44b33e78fe9fd2bf7 255 SUPERFAMILY SSF51735 15 254 5.0E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42655 9f23973c3e24362a3e0490e04ec62a59 344 Gene3D G3DSA:3.40.190.10 120 217 7.7E-28 T 17-03-2017 SHXM_RS42655 9f23973c3e24362a3e0490e04ec62a59 344 SUPERFAMILY SSF53850 42 262 1.54E-45 T 17-03-2017 SHXM_RS42655 9f23973c3e24362a3e0490e04ec62a59 344 SMART SM00062 42 256 1.8E-9 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS42655 9f23973c3e24362a3e0490e04ec62a59 344 TIGRFAM TIGR01728 SsuA_fam: ABC transporter, substrate-binding protein, aliphatic sulfonates family 45 326 9.3E-60 T 17-03-2017 IPR010067 Aliphatic sulfonates-binding protein GO:0006790|GO:0006810|GO:0016020 SHXM_RS42655 9f23973c3e24362a3e0490e04ec62a59 344 Pfam PF09084 NMT1/THI5 like 81 259 5.5E-13 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 Gene3D G3DSA:3.50.50.60 31 160 6.7E-24 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 135 153 2.8E-8 T 17-03-2017 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 34 53 2.8E-8 T 17-03-2017 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 285 307 2.8E-8 T 17-03-2017 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 SUPERFAMILY SSF51905 28 336 1.55E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 33 55 1.5E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 136 144 1.5E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 158 170 1.5E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 295 313 1.5E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 173 197 1.5E-14 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 Gene3D G3DSA:3.50.50.60 161 258 1.3E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS50680 f15d811b94f9d740944a3b2a7d4a8f05 348 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 33 309 3.3E-18 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 Gene3D G3DSA:3.40.50.1000 6 189 1.4E-32 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 87 184 8.1E-14 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 SUPERFAMILY SSF56784 7 190 2.65E-30 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 Pfam PF13419 Haloacid dehalogenase-like hydrolase 95 183 7.4E-11 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 4 15 7.1E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 149 169 7.1E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 101 114 7.1E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS31675 d2cab6ca1b311c69d7204e01497af8ca 220 PRINTS PR00413 Haloacid dehalogenase/epoxide hydrolase family signature 131 147 7.1E-12 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 SUPERFAMILY SSF54826 4 125 8.75E-25 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 TIGRFAM TIGR01928 menC_lowGC/arch: o-succinylbenzoate synthase 12 332 2.9E-91 T 17-03-2017 IPR010197 o-succinylbenzoate synthase, MenC type 2 GO:0009234|GO:0016829 KEGG: 00010+4.2.1.11|KEGG: 00130+4.2.1.113|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-5837|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 Hamap MF_01933 o-succinylbenzoate synthase [menC]. 3 360 40.941 T 17-03-2017 IPR010197 o-succinylbenzoate synthase, MenC type 2 GO:0009234|GO:0016829 KEGG: 00010+4.2.1.11|KEGG: 00130+4.2.1.113|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-5837|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 Gene3D G3DSA:3.20.20.120 132 351 1.3E-66 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 SUPERFAMILY SSF51604 124 360 3.41E-65 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 Pfam PF13378 Enolase C-terminal domain-like 148 355 2.5E-47 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 Gene3D G3DSA:3.30.390.10 2 131 5.8E-38 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS39880 68ba6844c6fb13317b20d2cf6f6c9d32 369 SMART SM00922 143 236 1.1E-18 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS19425 a020a819e9f7727cc3e41afd2fbc6409 276 Gene3D G3DSA:1.10.3720.10 4 263 4.0E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19425 a020a819e9f7727cc3e41afd2fbc6409 276 SUPERFAMILY SSF161098 3 275 1.87E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19425 a020a819e9f7727cc3e41afd2fbc6409 276 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 89 264 6.1E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47430 5e1eef5c7c7df14895e325de1d775ced 287 Gene3D G3DSA:3.90.226.10 9 229 3.3E-49 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47430 5e1eef5c7c7df14895e325de1d775ced 287 SUPERFAMILY SSF52096 10 245 7.85E-51 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47430 5e1eef5c7c7df14895e325de1d775ced 287 Pfam PF00378 Enoyl-CoA hydratase/isomerase 17 229 1.1E-34 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS00750 4d3f3b250d05cf8249ea0b61f8c86385 265 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 98 118 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS00750 4d3f3b250d05cf8249ea0b61f8c86385 265 Gene3D G3DSA:3.90.226.10 2 254 1.2E-75 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS00750 4d3f3b250d05cf8249ea0b61f8c86385 265 SUPERFAMILY SSF52096 3 257 1.51E-79 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS00750 4d3f3b250d05cf8249ea0b61f8c86385 265 Pfam PF00378 Enoyl-CoA hydratase/isomerase 11 255 4.0E-59 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS43220 bf2b0af6e68e8fc4133e4b35e1eec8fe 301 Pfam PF10977 Protein of unknown function (DUF2797) 72 272 1.7E-21 T 17-03-2017 IPR021246 Protein of unknown function DUF2797 SHXM_RS27665 62e0cfb59962c1389a4ae9718f1d5674 165 Pfam PF04314 Protein of unknown function (DUF461) 50 152 4.0E-27 T 17-03-2017 IPR007410 DR1885-like metal-binding protein SHXM_RS27665 62e0cfb59962c1389a4ae9718f1d5674 165 SUPERFAMILY SSF110087 18 158 1.96E-30 T 17-03-2017 IPR007410 DR1885-like metal-binding protein SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00385 P450 superfamily signature 318 329 1.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00385 P450 superfamily signature 393 402 1.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00385 P450 superfamily signature 266 283 1.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00385 P450 superfamily signature 402 413 1.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00463 E-class P450 group I signature 43 62 5.1E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00463 E-class P450 group I signature 392 402 5.1E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00463 E-class P450 group I signature 255 272 5.1E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00463 E-class P450 group I signature 275 301 5.1E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00463 E-class P450 group I signature 402 425 5.1E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 PRINTS PR00463 E-class P450 group I signature 357 381 5.1E-24 T 17-03-2017 IPR002401 Cytochrome P450, E-class, group I GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 SUPERFAMILY SSF48264 20 453 2.75E-110 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 Gene3D G3DSA:1.10.630.10 20 453 8.2E-121 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 395 404 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS43390 9f28eb9e102ed1171cdc8f5095a1a047 453 Pfam PF00067 Cytochrome P450 22 438 4.4E-82 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03210 3d84165015a7278cacee16a518c89516 128 Pfam PF01258 Prokaryotic dksA/traR C4-type zinc finger 89 123 2.0E-6 T 17-03-2017 IPR000962 Zinc finger, DksA/TraR C4-type GO:0008270 SHXM_RS42610 e713361bd00325bff6e93ab08e26234d 218 Gene3D G3DSA:1.20.120.450 4 85 3.6E-8 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS42610 e713361bd00325bff6e93ab08e26234d 218 SUPERFAMILY SSF109854 2 151 6.23E-12 T 17-03-2017 SHXM_RS42610 e713361bd00325bff6e93ab08e26234d 218 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 6 149 1.0E-20 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS17200 6ee110879b479e4955ed2f0301610d56 220 TIGRFAM TIGR00567 3mg: DNA-3-methyladenine glycosylase 10 201 1.9E-52 T 17-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 SHXM_RS17200 6ee110879b479e4955ed2f0301610d56 220 SUPERFAMILY SSF50486 8 206 4.08E-62 T 17-03-2017 IPR011034 Formyl transferase, C-terminal-like GO:0003824 SHXM_RS17200 6ee110879b479e4955ed2f0301610d56 220 Hamap MF_00527 Putative 3-methyladenine DNA glycosylase. 12 201 34.458 T 17-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 SHXM_RS17200 6ee110879b479e4955ed2f0301610d56 220 Pfam PF02245 Methylpurine-DNA glycosylase (MPG) 14 198 3.5E-65 T 17-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 SHXM_RS17200 6ee110879b479e4955ed2f0301610d56 220 Gene3D G3DSA:3.10.300.10 8 210 1.2E-70 T 17-03-2017 IPR003180 Methylpurine-DNA glycosylase (MPG) GO:0003677|GO:0003905|GO:0006284 Reactome: R-HSA-110330|Reactome: R-HSA-110331|Reactome: R-HSA-110357 SHXM_RS35985 39fbba03d36b720e3b0494631e050ec6 586 SUPERFAMILY SSF53850 54 579 9.15E-92 T 17-03-2017 SHXM_RS35985 39fbba03d36b720e3b0494631e050ec6 586 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 103 493 1.6E-72 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS35985 39fbba03d36b720e3b0494631e050ec6 586 PIRSF PIRSF002741 8 581 3.2E-56 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS35985 39fbba03d36b720e3b0494631e050ec6 586 Gene3D G3DSA:3.10.105.10 344 553 2.8E-32 T 17-03-2017 SHXM_RS35985 39fbba03d36b720e3b0494631e050ec6 586 Gene3D G3DSA:3.40.190.10 236 343 8.3E-19 T 17-03-2017 SHXM_RS35985 39fbba03d36b720e3b0494631e050ec6 586 Gene3D G3DSA:3.90.76.10 65 235 7.1E-35 T 17-03-2017 SHXM_RS41230 666a0a0f4c0f3b6e5cb41bb9d182ef34 303 Gene3D G3DSA:3.40.830.10 50 295 3.9E-71 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS41230 666a0a0f4c0f3b6e5cb41bb9d182ef34 303 Pfam PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase 79 282 2.2E-35 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS41230 666a0a0f4c0f3b6e5cb41bb9d182ef34 303 SUPERFAMILY SSF53213 55 296 3.92E-67 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS41230 666a0a0f4c0f3b6e5cb41bb9d182ef34 303 PIRSF PIRSF006157 51 303 1.2E-67 T 17-03-2017 IPR014436 Extradiol aromatic ring-opening dioxygenase, DODA type GO:0008270|GO:0016701|GO:0055114 SHXM_RS28725 95f0e41bf4c31033ec22f479d17884d3 333 SUPERFAMILY SSF54506 2 331 2.92E-118 T 17-03-2017 SHXM_RS28725 95f0e41bf4c31033ec22f479d17884d3 333 Gene3D G3DSA:3.10.310.10 3 155 2.1E-69 T 17-03-2017 SHXM_RS28725 95f0e41bf4c31033ec22f479d17884d3 333 Pfam PF05544 Proline racemase 10 331 1.8E-131 T 17-03-2017 IPR008794 Proline racemase family SHXM_RS28725 95f0e41bf4c31033ec22f479d17884d3 333 PIRSF PIRSF029792 1 333 6.1E-133 T 17-03-2017 IPR008794 Proline racemase family SHXM_RS28725 95f0e41bf4c31033ec22f479d17884d3 333 Gene3D G3DSA:3.10.310.10 156 320 2.7E-65 T 17-03-2017 SHXM_RS03820 74ed89c56d66fe7bf0c0b7f3043badee 428 Pfam PF06889 Protein of unknown function (DUF1266) 211 427 4.4E-46 T 17-03-2017 IPR009677 Protein of unknown function DUF1266 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 278 289 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 143 159 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 351 360 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 96 107 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 360 371 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 160 175 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 197 219 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00359 B-class P450 signature 296 323 2.8E-49 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 353 362 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 SUPERFAMILY SSF48264 19 411 6.16E-87 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 Gene3D G3DSA:1.10.630.10 16 411 3.8E-113 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00385 P450 superfamily signature 360 371 7.1E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00385 P450 superfamily signature 351 360 7.1E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00385 P450 superfamily signature 278 289 7.1E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 PRINTS PR00385 P450 superfamily signature 243 260 7.1E-8 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS03100 9e97bef9804fbea0d89c33667d689277 411 Pfam PF00067 Cytochrome P450 280 379 1.5E-15 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS10115 565b0093360f87678a8da61afce08c93 281 SUPERFAMILY SSF52540 3 208 3.04E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10115 565b0093360f87678a8da61afce08c93 281 Gene3D G3DSA:3.40.50.300 3 175 4.9E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 17 34 7.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 91 102 7.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 186 203 7.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 165 184 7.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 139 155 7.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 222 242 7.2E-35 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 16 186 4.1E-4 T 17-03-2017 SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 22 257 2.0E-62 T 17-03-2017 SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 SUPERFAMILY SSF51735 15 258 4.77E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16130 60821296c599e0367b2441fc3c901f87 260 Gene3D G3DSA:3.40.50.720 11 258 2.5E-80 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19655 ae1dae3e59899407074ba85c722ed955 460 Gene3D G3DSA:1.20.1250.20 20 222 3.5E-16 T 17-03-2017 SHXM_RS19655 ae1dae3e59899407074ba85c722ed955 460 Gene3D G3DSA:1.20.1250.20 255 447 2.1E-23 T 17-03-2017 SHXM_RS19655 ae1dae3e59899407074ba85c722ed955 460 ProSitePatterns PS00217 Sugar transport proteins signature 2. 129 154 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS19655 ae1dae3e59899407074ba85c722ed955 460 Pfam PF00083 Sugar (and other) transporter 18 431 3.5E-26 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS19655 ae1dae3e59899407074ba85c722ed955 460 SUPERFAMILY SSF103473 9 444 8.37E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 SUPERFAMILY SSF51735 2 248 3.78E-73 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 Gene3D G3DSA:3.40.50.720 2 248 1.7E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 10 248 8.8E-56 T 17-03-2017 SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 2.4E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 174 2.4E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 83 94 2.4E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 2 19 2.4E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 211 231 2.4E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 129 145 2.4E-34 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 83 94 9.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15555 f2b2a765b64ad399319a9413b7aef836 263 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 155 174 9.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 Gene3D G3DSA:3.10.450.50 174 287 1.3E-13 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 SUPERFAMILY SSF54427 176 290 2.02E-16 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 Pfam PF08281 Sigma-70, region 4 111 161 3.5E-7 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 Gene3D G3DSA:1.10.1740.10 7 76 2.5E-14 T 17-03-2017 SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 Gene3D G3DSA:1.10.10.10 108 164 4.5E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 SUPERFAMILY SSF88659 105 163 1.74E-8 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 7 163 2.5E-14 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 Pfam PF04542 Sigma-70 region 2 11 74 2.0E-13 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS07635 a3e6643ad25e6773424e29b8a5fb3880 296 SUPERFAMILY SSF88946 8 89 3.18E-15 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS08805 684b2aef8c1d0929c1f77a73f293df1d 278 Gene3D G3DSA:1.10.10.10 18 75 5.8E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08805 684b2aef8c1d0929c1f77a73f293df1d 278 SUPERFAMILY SSF46785 20 88 8.09E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 139 167 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 74 85 4.0E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 4.0E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 4.0E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 212 232 4.0E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 4.0E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 152 171 7.9E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 74 85 7.9E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 Gene3D G3DSA:3.40.50.720 3 248 6.5E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 15 248 1.0E-53 T 17-03-2017 SHXM_RS16040 61891bf90082fec356a901df229b14c9 258 SUPERFAMILY SSF51735 9 248 1.79E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33955 9f66e34dbc31e5cc1cbb80fd3396bc78 325 Gene3D G3DSA:1.10.3720.10 97 316 1.2E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33955 9f66e34dbc31e5cc1cbb80fd3396bc78 325 SUPERFAMILY SSF161098 99 308 2.09E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33955 9f66e34dbc31e5cc1cbb80fd3396bc78 325 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 124 323 1.4E-35 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05430 47acf9232de51ba041fcaad7e97fe34f 318 SUPERFAMILY SSF161098 81 304 3.4E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05430 47acf9232de51ba041fcaad7e97fe34f 318 Gene3D G3DSA:1.10.3720.10 85 314 7.8E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05430 47acf9232de51ba041fcaad7e97fe34f 318 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 310 2.0E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 Gene3D G3DSA:3.50.50.60 2 166 4.6E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 Gene3D G3DSA:3.50.50.60 270 353 4.6E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 Pfam PF01494 FAD binding domain 2 66 1.5E-7 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 140 155 8.7E-15 T 17-03-2017 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 2 24 8.7E-15 T 17-03-2017 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 283 298 8.7E-15 T 17-03-2017 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 SUPERFAMILY SSF51905 2 161 3.24E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27960 916b96b637d836e91d2c6d14607a600a 369 SUPERFAMILY SSF51905 278 362 3.24E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS09480 e950ed4197bd85801b9c77ebef5cff74 360 Gene3D G3DSA:3.90.1150.10 309 359 8.5E-5 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS09480 e950ed4197bd85801b9c77ebef5cff74 360 Pfam PF00266 Aminotransferase class-V 19 352 3.0E-19 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS09480 e950ed4197bd85801b9c77ebef5cff74 360 Gene3D G3DSA:3.40.640.10 43 270 1.1E-32 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS09480 e950ed4197bd85801b9c77ebef5cff74 360 SUPERFAMILY SSF53383 2 358 3.02E-53 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS36805 05e01456b622e18493c168b842b964f4 449 TIGRFAM TIGR00700 GABAtrnsam: 4-aminobutyrate transaminase 31 446 7.7E-180 T 17-03-2017 IPR004632 4-aminobutyrate aminotransferase, bacterial GO:0003867|GO:0009448 SHXM_RS36805 05e01456b622e18493c168b842b964f4 449 SUPERFAMILY SSF53383 42 448 2.42E-124 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS36805 05e01456b622e18493c168b842b964f4 449 Gene3D G3DSA:3.90.1150.10 330 448 2.2E-40 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS36805 05e01456b622e18493c168b842b964f4 449 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 262 299 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS36805 05e01456b622e18493c168b842b964f4 449 Gene3D G3DSA:3.40.640.10 81 329 5.3E-80 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS36805 05e01456b622e18493c168b842b964f4 449 Pfam PF00202 Aminotransferase class-III 43 445 8.1E-121 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS38455 f18ccba7343b8d7e50fffb40a9508fce 445 Pfam PF00005 ABC transporter 18 148 1.4E-17 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS38455 f18ccba7343b8d7e50fffb40a9508fce 445 SMART SM00382 27 198 8.0E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS38455 f18ccba7343b8d7e50fffb40a9508fce 445 Gene3D G3DSA:3.40.50.300 3 200 4.7E-36 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38455 f18ccba7343b8d7e50fffb40a9508fce 445 SUPERFAMILY SSF52540 2 200 1.26E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06160 64e9ef634d5a295c1ae75674710591ec 223 TIGRFAM TIGR03888 nitrile_beta: nitrile hydratase, beta subunit 1 221 3.1E-54 T 17-03-2017 IPR003168 Nitrile hydratase, beta subunit GO:0006807|GO:0018822|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06160 64e9ef634d5a295c1ae75674710591ec 223 Gene3D G3DSA:2.30.30.50 138 221 8.1E-34 T 17-03-2017 SHXM_RS06160 64e9ef634d5a295c1ae75674710591ec 223 Gene3D G3DSA:1.10.472.20 1 137 2.0E-33 T 17-03-2017 SHXM_RS06160 64e9ef634d5a295c1ae75674710591ec 223 Pfam PF02211 Nitrile hydratase beta subunit 1 220 4.0E-69 T 17-03-2017 IPR024690 Nitrile hydratase beta subunit domain GO:0018822 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06160 64e9ef634d5a295c1ae75674710591ec 223 PIRSF PIRSF001427 1 222 1.2E-54 T 17-03-2017 IPR003168 Nitrile hydratase, beta subunit GO:0006807|GO:0018822|GO:0046914 KEGG: 00364+4.2.1.84|KEGG: 00380+4.2.1.84|KEGG: 00627+4.2.1.84|KEGG: 00643+4.2.1.84|MetaCyc: PWY-5025|MetaCyc: PWY-581|MetaCyc: PWY-7308 SHXM_RS06160 64e9ef634d5a295c1ae75674710591ec 223 SUPERFAMILY SSF50090 1 221 4.71E-60 T 17-03-2017 IPR008990 Electron transport accessory protein-like domain SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 PIRSF PIRSF000144 6 760 0.0 T 17-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 Pfam PF01568 Molydopterin dinucleotide binding domain 643 750 1.2E-10 T 17-03-2017 IPR006657 Molybdopterin dinucleotide-binding domain GO:0016491|GO:0030151|GO:0055114 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 SUPERFAMILY SSF53706 58 632 4.32E-143 T 17-03-2017 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 Gene3D G3DSA:3.40.50.740 396 629 9.2E-55 T 17-03-2017 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 Gene3D G3DSA:3.40.50.740 120 193 9.2E-55 T 17-03-2017 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 SUPERFAMILY SSF50692 636 757 9.72E-19 T 17-03-2017 IPR009010 Aspartate decarboxylase-like domain SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 TIGRFAM TIGR01701 Fdhalpha-like: oxidoreductase alpha (molybdopterin) subunit 24 756 7.4E-291 T 17-03-2017 IPR010046 Oxidoreductase alpha (molybdopterin) subunit GO:0008863|GO:0030151|GO:0051539 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 Gene3D G3DSA:2.40.40.20 632 757 2.3E-12 T 17-03-2017 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 Gene3D G3DSA:3.40.228.10 194 395 5.4E-55 T 17-03-2017 SHXM_RS18135 b970f1e6a7040fd9fd5b1c8be1f4cfdd 760 Pfam PF00384 Molybdopterin oxidoreductase 120 489 1.2E-28 T 17-03-2017 IPR006656 Molybdopterin oxidoreductase GO:0016491|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS42170 d7ba56f6bc2a0846511cccc8fd441066 362 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 130 1.1E-15 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS42170 d7ba56f6bc2a0846511cccc8fd441066 362 Gene3D G3DSA:3.40.50.720 168 285 4.6E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42170 d7ba56f6bc2a0846511cccc8fd441066 362 Gene3D G3DSA:3.90.180.10 1 167 1.9E-35 T 17-03-2017 IPR011032 GroES-like SHXM_RS42170 d7ba56f6bc2a0846511cccc8fd441066 362 SUPERFAMILY SSF51735 137 290 1.97E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42170 d7ba56f6bc2a0846511cccc8fd441066 362 SUPERFAMILY SSF50129 1 169 2.67E-40 T 17-03-2017 IPR011032 GroES-like SHXM_RS42170 d7ba56f6bc2a0846511cccc8fd441066 362 Pfam PF00107 Zinc-binding dehydrogenase 170 288 1.9E-18 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS40680 d9b1829921a9d169760ab1868d39105e 191 SUPERFAMILY SSF51182 6 176 8.63E-53 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS40680 d9b1829921a9d169760ab1868d39105e 191 TIGRFAM TIGR03037 anthran_nbaC: 3-hydroxyanthranilate 3,4-dioxygenase 10 170 3.1E-73 T 17-03-2017 IPR010329 3-hydroxyanthranilic acid dioxygenase GO:0000334|GO:0005506|GO:0055114 KEGG: 00380+1.13.11.6|MetaCyc: PWY-5647|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-6505|Reactome: R-HSA-71240 SHXM_RS40680 d9b1829921a9d169760ab1868d39105e 191 Pfam PF06052 3-hydroxyanthranilic acid dioxygenase 8 158 1.3E-50 T 17-03-2017 IPR010329 3-hydroxyanthranilic acid dioxygenase GO:0000334|GO:0005506|GO:0055114 KEGG: 00380+1.13.11.6|MetaCyc: PWY-5647|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-6505|Reactome: R-HSA-71240 SHXM_RS40680 d9b1829921a9d169760ab1868d39105e 191 Hamap MF_00825 3-hydroxyanthranilate 3,4-dioxygenase [nbaC]. 6 176 33.829 T 17-03-2017 IPR010329 3-hydroxyanthranilic acid dioxygenase GO:0000334|GO:0005506|GO:0055114 KEGG: 00380+1.13.11.6|MetaCyc: PWY-5647|MetaCyc: PWY-5651|MetaCyc: PWY-6309|MetaCyc: PWY-6505|Reactome: R-HSA-71240 SHXM_RS40680 d9b1829921a9d169760ab1868d39105e 191 Gene3D G3DSA:2.60.120.10 7 119 1.3E-19 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS19075 9670b222e3f49942446abd86f752550d 547 Gene3D G3DSA:1.25.40.10 319 343 3.8E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS19075 9670b222e3f49942446abd86f752550d 547 Gene3D G3DSA:1.25.40.10 439 508 3.8E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS33115 b95ca3374fedaa06523a47ffd3367f6a 177 SUPERFAMILY SSF53335 2 129 1.83E-8 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS33115 b95ca3374fedaa06523a47ffd3367f6a 177 Gene3D G3DSA:3.40.50.150 2 72 3.5E-8 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS33115 b95ca3374fedaa06523a47ffd3367f6a 177 Gene3D G3DSA:3.40.50.150 104 174 3.5E-8 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS45920 798c561cef2cca5cdf2a490bde75475a 222 Pfam PF09335 SNARE associated Golgi protein 46 176 3.9E-17 T 17-03-2017 IPR032816 SNARE associated Golgi protein SHXM_RS33280 ed6a1fa2bedbe81398a1a9d234027df9 403 Gene3D G3DSA:3.90.1150.10 278 401 1.5E-40 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS33280 ed6a1fa2bedbe81398a1a9d234027df9 403 SUPERFAMILY SSF53383 6 398 3.4E-95 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS33280 ed6a1fa2bedbe81398a1a9d234027df9 403 Pfam PF00155 Aminotransferase class I and II 34 391 5.3E-52 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS33280 ed6a1fa2bedbe81398a1a9d234027df9 403 Gene3D G3DSA:3.40.640.10 50 277 2.8E-68 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS44215 ce76a721b838641f2f339f6c898b8b4a 224 SUPERFAMILY SSF56235 1 223 1.31E-58 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS44215 ce76a721b838641f2f339f6c898b8b4a 224 Gene3D G3DSA:3.60.20.10 1 214 5.6E-57 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS44215 ce76a721b838641f2f339f6c898b8b4a 224 Pfam PF06267 Family of unknown function (DUF1028) 2 191 2.8E-52 T 17-03-2017 IPR010430 Protein of unknown function DUF1028 SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 Pfam PF00501 AMP-binding enzyme 8 387 1.9E-67 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 Pfam PF13193 AMP-binding enzyme C-terminal domain 397 471 1.0E-16 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 Gene3D G3DSA:3.40.50.980 3 139 4.4E-17 T 17-03-2017 SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 Gene3D G3DSA:3.40.50.980 140 294 2.7E-26 T 17-03-2017 SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 ProSitePatterns PS00455 Putative AMP-binding domain signature. 135 146 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 SUPERFAMILY SSF56801 2 483 3.92E-102 T 17-03-2017 SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 Gene3D G3DSA:3.30.300.30 383 479 4.9E-23 T 17-03-2017 SHXM_RS04595 f6ab6aaa69aac7bff16cb44f42bebfb6 488 Gene3D G3DSA:2.30.38.10 306 381 9.9E-22 T 17-03-2017 SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 Gene3D G3DSA:1.10.3810.10 108 283 3.4E-65 T 17-03-2017 SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 SUPERFAMILY SSF56601 267 286 8.23E-82 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 SUPERFAMILY SSF56601 315 685 8.23E-82 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 Pfam PF00905 Penicillin binding protein transpeptidase domain 385 640 5.9E-29 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 Gene3D G3DSA:3.40.710.10 284 712 2.6E-100 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 SUPERFAMILY SSF53955 97 297 2.02E-62 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS23350 05a147082d7030f167da4845bf3a89bf 780 Pfam PF00912 Transglycosylase 110 282 1.4E-58 T 17-03-2017 IPR001264 Glycosyl transferase, family 51 SHXM_RS34485 a238d525f4169cfef28c612a3885809c 328 SUPERFAMILY SSF48452 14 112 9.07E-11 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34485 a238d525f4169cfef28c612a3885809c 328 Gene3D G3DSA:1.25.40.10 21 110 5.1E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS00475 c94a2b13c2e27d4517f632917110ba8e 326 TIGRFAM TIGR04187 GRASP_SAV_5884: ATP-grasp ribosomal peptide maturase, SAV_5884 family 5 318 2.0E-119 T 17-03-2017 IPR026449 ATP-grasp ribosomal peptide maturase, SAV_5884 family SHXM_RS00475 c94a2b13c2e27d4517f632917110ba8e 326 SUPERFAMILY SSF56059 137 305 7.07E-16 T 17-03-2017 SHXM_RS00475 c94a2b13c2e27d4517f632917110ba8e 326 Gene3D G3DSA:3.30.1490.20 146 169 3.0E-4 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS01680 d41f7018635c87cf6c23c3e5254669b4 353 SUPERFAMILY SSF51556 43 272 1.11E-67 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS01680 d41f7018635c87cf6c23c3e5254669b4 353 SUPERFAMILY SSF51556 301 350 1.11E-67 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS01680 d41f7018635c87cf6c23c3e5254669b4 353 Gene3D G3DSA:3.20.20.140 41 351 4.9E-73 T 17-03-2017 SHXM_RS01680 d41f7018635c87cf6c23c3e5254669b4 353 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 39 345 1.1E-69 T 17-03-2017 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533|Reactome: R-HSA-2142691|Reactome: R-HSA-5423646 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Gene3D G3DSA:3.30.420.40 10 157 7.5E-49 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 67 90 9.7E-42 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 130 149 9.7E-42 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 185 205 9.7E-42 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 PRINTS PR01652 Bacterial cell shape determinant MreB/Mbl protein signature 47 65 9.7E-42 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Gene3D G3DSA:3.90.640.10 185 224 1.3E-29 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Gene3D G3DSA:3.90.640.10 260 293 1.3E-29 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 SUPERFAMILY SSF53067 10 146 3.14E-43 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 SUPERFAMILY SSF53067 151 360 2.72E-39 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Gene3D G3DSA:3.30.420.40 297 351 9.5E-35 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Gene3D G3DSA:3.30.420.40 158 184 9.5E-35 T 17-03-2017 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Pfam PF06723 MreB/Mbl protein 263 369 4.8E-37 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS31595 2d4c2dd7e28010b1d83d0effca77c625 385 Pfam PF06723 MreB/Mbl protein 10 222 5.3E-101 T 17-03-2017 IPR004753 Cell shape determining protein MreB/Mrl GO:0000902 SHXM_RS36635 619448ae7e59ed26c2de0c16810fea05 412 TIGRFAM TIGR00732 dprA: DNA protecting protein DprA 90 307 4.1E-61 T 17-03-2017 IPR003488 DNA recombination-mediator protein A GO:0009294 SHXM_RS36635 619448ae7e59ed26c2de0c16810fea05 412 Pfam PF02481 DNA recombination-mediator protein A 93 301 2.0E-66 T 17-03-2017 IPR003488 DNA recombination-mediator protein A GO:0009294 SHXM_RS36635 619448ae7e59ed26c2de0c16810fea05 412 Gene3D G3DSA:1.10.10.10 335 385 3.1E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36635 619448ae7e59ed26c2de0c16810fea05 412 SUPERFAMILY SSF102405 101 310 1.4E-36 T 17-03-2017 SHXM_RS36635 619448ae7e59ed26c2de0c16810fea05 412 Gene3D G3DSA:3.40.50.450 136 275 1.8E-14 T 17-03-2017 SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 28 260 1.3E-48 T 17-03-2017 SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 20 199 4.7E-4 T 17-03-2017 SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 SUPERFAMILY SSF51735 20 261 3.2E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 168 187 2.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 149 157 2.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 82 93 2.7E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 21 38 1.8E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 168 187 1.8E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 227 247 1.8E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 82 93 1.8E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 189 206 1.8E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 143 159 1.8E-31 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS08345 5e6fe9dd7f7a72827ae2a55e9a33bafa 271 Gene3D G3DSA:3.40.50.720 18 263 7.0E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34090 ec2e3dd03f7521a30af0f8c9eae3a2e2 77 Pfam PF11314 Protein of unknown function (DUF3117) 26 75 8.9E-29 T 17-03-2017 IPR021465 Protein of unknown function DUF3117 SHXM_RS36265 dda915b3da7b8a0920035edb74aaf693 220 Pfam PF05331 Protein of unknown function (DUF742) 108 220 4.0E-40 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS25905 4642550727825eae59f01073a5a40c04 329 SUPERFAMILY SSF49785 197 324 3.57E-11 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS25905 4642550727825eae59f01073a5a40c04 329 Gene3D G3DSA:2.60.120.260 199 326 7.2E-13 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48305 a4cc03e85e6fd93142b0dd5c6fa3da5b 179 SUPERFAMILY SSF49785 22 92 5.1E-12 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48305 a4cc03e85e6fd93142b0dd5c6fa3da5b 179 Gene3D G3DSA:2.60.120.260 20 92 4.0E-13 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS48305 a4cc03e85e6fd93142b0dd5c6fa3da5b 179 Pfam PF00754 F5/8 type C domain 22 90 5.2E-9 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS16205 173a31df860f50fed4b11284253267f2 132 Pfam PF01242 6-pyruvoyl tetrahydropterin synthase 4 130 1.6E-21 T 17-03-2017 IPR007115 6-pyruvoyl tetrahydropterin synthase/QueD family protein Reactome: R-HSA-1474151 SHXM_RS16205 173a31df860f50fed4b11284253267f2 132 Gene3D G3DSA:3.30.479.10 2 130 4.5E-41 T 17-03-2017 SHXM_RS16205 173a31df860f50fed4b11284253267f2 132 SUPERFAMILY SSF55620 2 129 1.22E-27 T 17-03-2017 SHXM_RS18635 392a74352d2f4a684ed9bd30c404ee09 260 Gene3D G3DSA:3.40.50.150 45 258 5.8E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS18635 392a74352d2f4a684ed9bd30c404ee09 260 Pfam PF13489 Methyltransferase domain 18 206 1.6E-16 T 17-03-2017 SHXM_RS18635 392a74352d2f4a684ed9bd30c404ee09 260 SUPERFAMILY SSF53335 40 214 6.23E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS48740 3c813449e4891824d6c2dde15ead723f 443 Gene3D G3DSA:3.40.190.10 155 355 1.1E-35 T 17-03-2017 SHXM_RS48740 3c813449e4891824d6c2dde15ead723f 443 Pfam PF01547 Bacterial extracellular solute-binding protein 52 337 8.8E-27 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS48740 3c813449e4891824d6c2dde15ead723f 443 Gene3D G3DSA:3.40.190.10 10 119 5.4E-10 T 17-03-2017 SHXM_RS48740 3c813449e4891824d6c2dde15ead723f 443 SUPERFAMILY SSF53850 22 436 6.52E-55 T 17-03-2017 SHXM_RS37515 ea2d13ba385c931629584890d6202f90 454 SUPERFAMILY SSF63411 249 439 1.02E-27 T 17-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SHXM_RS37515 ea2d13ba385c931629584890d6202f90 454 Pfam PF00675 Insulinase (Peptidase family M16) 26 164 2.6E-21 T 17-03-2017 IPR011765 Peptidase M16, N-terminal SHXM_RS37515 ea2d13ba385c931629584890d6202f90 454 Pfam PF05193 Peptidase M16 inactive domain 185 363 1.1E-29 T 17-03-2017 IPR007863 Peptidase M16, C-terminal SHXM_RS37515 ea2d13ba385c931629584890d6202f90 454 Gene3D G3DSA:3.30.830.10 254 428 7.8E-19 T 17-03-2017 IPR011237 Peptidase M16 domain GO:0046872 SHXM_RS37515 ea2d13ba385c931629584890d6202f90 454 SUPERFAMILY SSF63411 16 223 1.23E-59 T 17-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SHXM_RS37515 ea2d13ba385c931629584890d6202f90 454 Gene3D G3DSA:3.30.830.10 18 235 8.9E-60 T 17-03-2017 IPR011237 Peptidase M16 domain GO:0046872 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 SUPERFAMILY SSF46894 154 221 3.3E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 Pfam PF00196 Bacterial regulatory proteins, luxR family 160 215 4.4E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 SMART SM00421 158 215 3.2E-25 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 175 191 8.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 161 175 8.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 191 203 8.8E-12 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 SMART SM00448 3 118 8.3E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 Pfam PF00072 Response regulator receiver domain 5 119 1.5E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 SUPERFAMILY SSF52172 3 129 5.69E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 ProSitePatterns PS00622 LuxR-type HTH domain signature. 175 202 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 Gene3D G3DSA:3.40.50.2300 1 123 8.9E-35 T 17-03-2017 SHXM_RS18945 804e23319317eca8dc4c48bb6d56779c 225 Gene3D G3DSA:1.10.10.10 124 222 6.8E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30260 94ed51f5c0bd5b874a50167328feab93 155 Gene3D G3DSA:3.10.180.10 2 141 3.2E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS30260 94ed51f5c0bd5b874a50167328feab93 155 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 8 136 4.9E-14 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS30260 94ed51f5c0bd5b874a50167328feab93 155 SUPERFAMILY SSF54593 1 142 1.33E-25 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 ProSitePatterns PS00382 Endopeptidase Clp histidine active site. 125 138 - T 17-03-2017 IPR033135 ClpP, histidine active site SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 15 206 38.077 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 PRINTS PR00127 Clp protease catalytic subunit P signature 124 143 4.9E-43 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 PRINTS PR00127 Clp protease catalytic subunit P signature 72 92 4.9E-43 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 PRINTS PR00127 Clp protease catalytic subunit P signature 181 200 4.9E-43 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 PRINTS PR00127 Clp protease catalytic subunit P signature 103 120 4.9E-43 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 PRINTS PR00127 Clp protease catalytic subunit P signature 32 47 4.9E-43 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 Pfam PF00574 Clp protease 33 204 1.5E-72 T 17-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 Gene3D G3DSA:3.90.226.10 33 205 1.2E-71 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS20055 4230e19669294fcacdab1ff1e25f68c6 220 SUPERFAMILY SSF52096 33 206 2.13E-62 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 SUPERFAMILY SSF56601 214 233 6.44E-80 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 SUPERFAMILY SSF56601 265 661 6.44E-80 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 Pfam PF00912 Transglycosylase 54 228 5.8E-51 T 17-03-2017 IPR001264 Glycosyl transferase, family 51 SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 Pfam PF00905 Penicillin binding protein transpeptidase domain 335 396 3.1E-7 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 Pfam PF00905 Penicillin binding protein transpeptidase domain 416 595 2.5E-23 T 17-03-2017 IPR001460 Penicillin-binding protein, transpeptidase GO:0008658 SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 Gene3D G3DSA:3.40.710.10 231 681 1.1E-96 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 Gene3D G3DSA:1.10.3810.10 53 230 1.4E-56 T 17-03-2017 SHXM_RS28015 ab588027ff7c66f3295ff3a24a53bc54 764 SUPERFAMILY SSF53955 35 247 3.66E-58 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS34505 84ccba767eab972227423420fafcba43 168 Pfam PF00583 Acetyltransferase (GNAT) family 63 143 1.9E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS34505 84ccba767eab972227423420fafcba43 168 Gene3D G3DSA:3.40.630.30 1 148 5.1E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS34505 84ccba767eab972227423420fafcba43 168 SUPERFAMILY SSF55729 1 149 1.58E-24 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS17540 5e6e5b6e3c9536f3b2f6454f9b8c8c50 166 Pfam PF01890 Cobalamin synthesis G C-terminus 17 141 1.9E-31 T 17-03-2017 IPR002750 CobE/GbiG C-terminal domain GO:0009236 SHXM_RS17540 5e6e5b6e3c9536f3b2f6454f9b8c8c50 166 SUPERFAMILY SSF159664 16 144 2.75E-33 T 17-03-2017 IPR002750 CobE/GbiG C-terminal domain GO:0009236 SHXM_RS17540 5e6e5b6e3c9536f3b2f6454f9b8c8c50 166 Gene3D G3DSA:3.30.420.180 16 143 6.8E-33 T 17-03-2017 IPR002750 CobE/GbiG C-terminal domain GO:0009236 SHXM_RS17175 aa503c5cdb0969c60b4233201223ec9c 329 Gene3D G3DSA:1.25.40.10 168 205 2.5E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS17175 aa503c5cdb0969c60b4233201223ec9c 329 Gene3D G3DSA:1.25.40.10 47 126 2.5E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS17175 aa503c5cdb0969c60b4233201223ec9c 329 Pfam PF14559 Tetratricopeptide repeat 149 207 3.6E-6 T 17-03-2017 SHXM_RS17175 aa503c5cdb0969c60b4233201223ec9c 329 SUPERFAMILY SSF48452 44 206 2.4E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 60 75 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 104 117 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 118 131 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 PRINTS PR00111 Alpha/beta hydrolase fold signature 227 241 4.4E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 SUPERFAMILY SSF53474 10 282 2.26E-58 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 Pfam PF00561 alpha/beta hydrolase fold 36 143 1.2E-15 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 Pfam PF00561 alpha/beta hydrolase fold 213 269 6.2E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45790 bec311f0ed47b2d3a8fbb663b4f11669 287 Gene3D G3DSA:3.40.50.1820 11 282 1.8E-59 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26475 c39e08ca637002d88a27476345fde2d2 163 ProSitePatterns PS00387 Inorganic pyrophosphatase signature. 52 58 - T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS26475 c39e08ca637002d88a27476345fde2d2 163 SUPERFAMILY SSF50324 3 156 1.31E-57 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS26475 c39e08ca637002d88a27476345fde2d2 163 Gene3D G3DSA:3.90.80.10 2 158 4.6E-54 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS26475 c39e08ca637002d88a27476345fde2d2 163 Pfam PF00719 Inorganic pyrophosphatase 5 157 3.8E-52 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS26475 c39e08ca637002d88a27476345fde2d2 163 Hamap MF_00209 Inorganic pyrophosphatase [ppa]. 1 158 32.885 T 17-03-2017 IPR008162 Inorganic pyrophosphatase GO:0000287|GO:0004427|GO:0005737|GO:0006796 KEGG: 00190+3.6.1.1 SHXM_RS08815 c5fe403b1a21f59549f0de49c28bb620 479 SUPERFAMILY SSF53098 71 292 1.59E-9 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS08815 c5fe403b1a21f59549f0de49c28bb620 479 SUPERFAMILY SSF53098 324 395 1.59E-9 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS08815 c5fe403b1a21f59549f0de49c28bb620 479 Pfam PF13546 DDE superfamily endonuclease 23 283 3.6E-52 T 17-03-2017 SHXM_RS30195 3124e7c0becc5ae27533ae21b484dc47 86 Pfam PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 6 73 1.1E-19 T 17-03-2017 IPR000504 RNA recognition motif domain GO:0003676 SHXM_RS30195 3124e7c0becc5ae27533ae21b484dc47 86 Gene3D G3DSA:3.30.70.330 2 80 1.1E-26 T 17-03-2017 IPR012677 Nucleotide-binding alpha-beta plait domain GO:0000166 SHXM_RS30195 3124e7c0becc5ae27533ae21b484dc47 86 SUPERFAMILY SSF54928 3 82 3.9E-27 T 17-03-2017 IPR012677 Nucleotide-binding alpha-beta plait domain GO:0000166 SHXM_RS30195 3124e7c0becc5ae27533ae21b484dc47 86 SMART SM00360 4 76 1.0E-25 T 17-03-2017 IPR000504 RNA recognition motif domain GO:0003676 SHXM_RS11250 741194a47226775818483db5ec92808d 72 SUPERFAMILY SSF103473 4 65 1.16E-8 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS38545 9b852f00da46d820acc57ab17e48ba7a 286 Gene3D G3DSA:3.40.50.300 10 239 1.0E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38545 9b852f00da46d820acc57ab17e48ba7a 286 SUPERFAMILY SSF52540 7 237 1.41E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38545 9b852f00da46d820acc57ab17e48ba7a 286 Pfam PF00005 ABC transporter 24 174 5.7E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS38545 9b852f00da46d820acc57ab17e48ba7a 286 SMART SM00382 33 224 1.4E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SUPERFAMILY SSF89372 92 233 2.22E-8 T 17-03-2017 SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 Gene3D G3DSA:2.115.10.10 147 232 1.5E-4 T 17-03-2017 IPR023294 Tachylectin 2 SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 Gene3D G3DSA:2.115.10.10 51 146 3.3E-5 T 17-03-2017 IPR023294 Tachylectin 2 SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 79 113 0.0084 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 157 191 0.0011 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 2 36 3.5E-4 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 198 232 1.1E-5 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 40 74 2.4E-5 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS50695 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 117 151 0.0038 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SUPERFAMILY SSF89372 92 233 2.22E-8 T 17-03-2017 SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 Gene3D G3DSA:2.115.10.10 147 232 1.5E-4 T 17-03-2017 IPR023294 Tachylectin 2 SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 Gene3D G3DSA:2.115.10.10 51 146 3.3E-5 T 17-03-2017 IPR023294 Tachylectin 2 SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 79 113 0.0084 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 157 191 0.0011 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 2 36 3.5E-4 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 198 232 1.1E-5 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 40 74 2.4E-5 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS00630 6339cd25c520df9280aeb5ce4e3337ca 236 SMART SM00706 117 151 0.0038 T 17-03-2017 IPR006624 Beta-propeller repeat TECPR SHXM_RS09010 b3a77a2dcf09f8ee9fe55d2b5dbbbf8d 84 Pfam PF13358 DDE superfamily endonuclease 22 53 3.7E-7 T 17-03-2017 SHXM_RS49795 ddf1aa81a76259b730ad3a82a1df1465 296 SUPERFAMILY SSF51197 84 288 1.37E-19 T 17-03-2017 SHXM_RS49795 ddf1aa81a76259b730ad3a82a1df1465 296 Gene3D G3DSA:2.60.120.330 108 291 1.2E-17 T 17-03-2017 IPR027443 Isopenicillin N synthase-like SHXM_RS49795 ddf1aa81a76259b730ad3a82a1df1465 296 Pfam PF03171 2OG-Fe(II) oxygenase superfamily 157 252 6.0E-6 T 17-03-2017 IPR005123 Oxoglutarate/iron-dependent dioxygenase GO:0016491|GO:0055114 SHXM_RS18540 b0b1767289cc8a11e3f1e47563e71cbf 206 Pfam PF04472 Protein of unknown function (DUF552) 118 189 3.3E-27 T 17-03-2017 IPR007561 Cell division protein SepF/SepF-related GO:0090529 SHXM_RS18540 b0b1767289cc8a11e3f1e47563e71cbf 206 Hamap MF_01197 Cell division protein SepF [sepF]. 2 197 22.638 T 17-03-2017 IPR023052 Cell division protein SepF GO:0090529 SHXM_RS43700 25ccb8a484dc6edd84305aeea6d7204a 259 SUPERFAMILY SSF88713 9 258 6.3E-94 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS43700 25ccb8a484dc6edd84305aeea6d7204a 259 Hamap MF_00691 UPF0271 protein YbgL [ybgL]. 8 253 43.889 T 17-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SHXM_RS43700 25ccb8a484dc6edd84305aeea6d7204a 259 Pfam PF03746 LamB/YcsF family 10 248 7.6E-100 T 17-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SHXM_RS30820 4242dde1875f7e1451cb82c6f417bf02 550 Pfam PF00361 Proton-conducting membrane transporter 180 486 1.9E-72 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30820 4242dde1875f7e1451cb82c6f417bf02 550 TIGRFAM TIGR01770 NDH_I_N: proton-translocating NADH-quinone oxidoreductase, chain N 154 538 4.7E-115 T 17-03-2017 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 SHXM_RS30820 4242dde1875f7e1451cb82c6f417bf02 550 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 26 539 17.936 T 17-03-2017 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 SUPERFAMILY SSF46785 6 93 4.77E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 Gene3D G3DSA:1.10.10.10 6 94 1.0E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 49 64 2.2E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 16 31 2.2E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 64 79 2.2E-8 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 SMART SM00418 14 93 2.1E-20 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS19070 7ab90ed2499e4d0a43308a28644a0870 253 Pfam PF12840 Helix-turn-helix domain 14 73 1.3E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47890 406f92fe4695ca505e6bed990645d52e 420 Gene3D G3DSA:1.20.1250.20 2 195 2.3E-38 T 17-03-2017 SHXM_RS47890 406f92fe4695ca505e6bed990645d52e 420 SUPERFAMILY SSF103473 2 410 1.16E-70 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47890 406f92fe4695ca505e6bed990645d52e 420 Pfam PF07690 Major Facilitator Superfamily 4 374 3.2E-43 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS47890 406f92fe4695ca505e6bed990645d52e 420 Gene3D G3DSA:1.20.1250.20 226 414 1.1E-19 T 17-03-2017 SHXM_RS38585 e83f60b66896f390037f5f60b12d4a9e 333 SUPERFAMILY SSF161098 100 320 1.01E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38585 e83f60b66896f390037f5f60b12d4a9e 333 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 131 324 2.6E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38585 e83f60b66896f390037f5f60b12d4a9e 333 Gene3D G3DSA:1.10.3720.10 52 320 1.6E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01250 1e2814a4a0cea326e292cb19192d0645 105 Pfam PF03992 Antibiotic biosynthesis monooxygenase 9 79 7.1E-8 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS01250 1e2814a4a0cea326e292cb19192d0645 105 SUPERFAMILY SSF54909 6 94 2.41E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS01250 1e2814a4a0cea326e292cb19192d0645 105 Gene3D G3DSA:3.30.70.900 8 96 8.4E-10 T 17-03-2017 SHXM_RS41105 a06612fe7653b18e7d5cccce4174b5a7 97 SUPERFAMILY SSF54909 3 94 1.72E-23 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS41105 a06612fe7653b18e7d5cccce4174b5a7 97 Pfam PF02426 Muconolactone delta-isomerase 3 92 9.7E-29 T 17-03-2017 IPR026029 Muconolactone isomerase domain KEGG: 00362+5.3.3.4|MetaCyc: PWY-6185 SHXM_RS41105 a06612fe7653b18e7d5cccce4174b5a7 97 ProDom PD006619 ISOMERASE MUCONOLACTONE DELTA-ISOMERASE HYDROCARBONS MIASE AROMATIC CATABOLISM METHYLMUCONOLACTONE DIRECT SEQUENCING 3 46 1.0E-5 T 17-03-2017 IPR003464 Muconolactone delta-isomerase GO:0006725 KEGG: 00362+5.3.3.4|MetaCyc: PWY-6185 SHXM_RS25460 d8557d77ae65e5915470f56e4472b14d 458 Pfam PF09471 IgA Peptidase M64 107 359 2.4E-67 T 17-03-2017 IPR019026 Peptidase M64, IgA SHXM_RS15615 da66b8680e99f50e9eb314cee70dc974 197 SUPERFAMILY SSF46689 11 134 1.56E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15615 da66b8680e99f50e9eb314cee70dc974 197 Pfam PF13592 Winged helix-turn helix 101 158 1.5E-19 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS15615 da66b8680e99f50e9eb314cee70dc974 197 Pfam PF13518 Helix-turn-helix domain 20 69 9.0E-9 T 17-03-2017 SHXM_RS28325 49f16cce5692c48c9f3cd836f2f12a97 98 PIRSF PIRSF030200 1 98 1.9E-44 T 17-03-2017 IPR009359 Phenylacetic acid degradation B SHXM_RS28325 49f16cce5692c48c9f3cd836f2f12a97 98 Pfam PF06243 Phenylacetic acid degradation B 8 94 7.0E-40 T 17-03-2017 IPR009359 Phenylacetic acid degradation B SHXM_RS28325 49f16cce5692c48c9f3cd836f2f12a97 98 TIGRFAM TIGR02157 PA_CoA_Oxy2: phenylacetate-CoA oxygenase, PaaH subunit 9 97 9.7E-44 T 17-03-2017 IPR009359 Phenylacetic acid degradation B SHXM_RS32915 eabb426631a31a139b9e3632f3358a78 124 ProSitePatterns PS00234 Gas vesicles protein GVPa signature 1. 21 35 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS32915 eabb426631a31a139b9e3632f3358a78 124 Pfam PF00741 Gas vesicle protein 21 58 2.1E-15 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS22520 3b4810925c45981c92b2cade15c885fc 137 Gene3D G3DSA:2.70.98.40 47 136 1.6E-5 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS22520 3b4810925c45981c92b2cade15c885fc 137 Pfam PF03636 Glycosyl hydrolase family 65, N-terminal domain 51 136 6.1E-8 T 17-03-2017 IPR005196 Glycoside hydrolase, family 65, N-terminal GO:0003824|GO:0005975 SHXM_RS14700 faa27318506c000b34d8d351a7a629c2 328 Gene3D G3DSA:3.80.30.20 42 245 5.0E-5 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS14700 faa27318506c000b34d8d351a7a629c2 328 SUPERFAMILY SSF102114 42 281 2.62E-12 T 17-03-2017 SHXM_RS14700 faa27318506c000b34d8d351a7a629c2 328 Pfam PF04055 Radical SAM superfamily 43 214 5.8E-10 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS19510 060b49c3335da476ac034040105019c2 244 SMART SM00943 36 218 3.6E-38 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS19510 060b49c3335da476ac034040105019c2 244 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 38 212 5.9E-27 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS01085 04b63501bb4e422648f5e7f3454af0ce 110 SUPERFAMILY SSF53850 10 101 1.09E-6 T 17-03-2017 SHXM_RS01085 04b63501bb4e422648f5e7f3454af0ce 110 Pfam PF03466 LysR substrate binding domain 12 101 1.5E-7 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS01085 04b63501bb4e422648f5e7f3454af0ce 110 Gene3D G3DSA:3.40.190.10 12 84 4.1E-6 T 17-03-2017 SHXM_RS36990 01b5aef3dfeaeea511a1d23bf0709017 615 SUPERFAMILY SSF53474 384 537 3.12E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS36990 01b5aef3dfeaeea511a1d23bf0709017 615 Pfam PF06259 Alpha/beta hydrolase 372 540 4.3E-34 T 17-03-2017 IPR010427 Protein of unknown function DUF1023 SHXM_RS04180 83b8b18da2c806f10eaa5098f12ef45c 171 SMART SM00198 48 165 0.0038 T 17-03-2017 IPR014044 CAP domain SHXM_RS04180 83b8b18da2c806f10eaa5098f12ef45c 171 Gene3D G3DSA:3.40.33.10 47 163 1.1E-16 T 17-03-2017 IPR014044 CAP domain SHXM_RS04180 83b8b18da2c806f10eaa5098f12ef45c 171 Pfam PF00188 Cysteine-rich secretory protein family 55 167 7.5E-24 T 17-03-2017 IPR014044 CAP domain SHXM_RS04180 83b8b18da2c806f10eaa5098f12ef45c 171 SUPERFAMILY SSF55797 48 168 7.72E-27 T 17-03-2017 IPR014044 CAP domain SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 Gene3D G3DSA:1.10.357.10 59 197 1.3E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 SUPERFAMILY SSF46689 10 73 9.98E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 Gene3D G3DSA:1.10.10.60 11 58 3.0E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 5.2E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 5.2E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 SUPERFAMILY SSF48498 82 197 4.82E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 Pfam PF16859 Bacterial transcriptional repressor C-terminal 81 192 1.8E-28 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS46895 6b87c17dccb15cd5e1f2a9f2d7e001fa 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 65 2.4E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Gene3D G3DSA:2.60.40.10 683 777 7.6E-14 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SUPERFAMILY SSF49265 695 883 4.07E-23 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00060 787 875 1.2E-6 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00060 681 767 4.2E-7 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Pfam PF00041 Fibronectin type III domain 696 770 5.1E-10 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Pfam PF00041 Fibronectin type III domain 793 874 5.2E-9 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00710 491 512 510.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00710 404 426 3600.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00710 529 556 2100.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00710 589 610 2200.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00710 428 450 16.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SMART SM00710 463 488 6200.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Pfam PF13229 Right handed beta helix region 402 598 2.3E-8 T 17-03-2017 SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SUPERFAMILY SSF51126 40 137 3.0E-25 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 SUPERFAMILY SSF51126 361 647 3.0E-25 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Gene3D G3DSA:2.60.40.10 795 882 8.2E-11 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Gene3D G3DSA:2.160.20.10 395 647 9.7E-22 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS20660 c00ed214f0ad513b2f7c2f8ca7f8cb96 885 Gene3D G3DSA:2.160.20.10 42 169 9.7E-22 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS19810 831e723c85ec8200f3baabf9bbbdc80c 77 SUPERFAMILY SSF54862 5 62 1.32E-10 T 17-03-2017 SHXM_RS19810 831e723c85ec8200f3baabf9bbbdc80c 77 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 9 61 2.0E-9 T 17-03-2017 SHXM_RS19810 831e723c85ec8200f3baabf9bbbdc80c 77 Gene3D G3DSA:3.30.70.20 5 62 1.0E-12 T 17-03-2017 SHXM_RS19810 831e723c85ec8200f3baabf9bbbdc80c 77 PRINTS PR00352 3Fe-4S ferredoxin signature 49 61 1.6E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS19810 831e723c85ec8200f3baabf9bbbdc80c 77 PRINTS PR00352 3Fe-4S ferredoxin signature 20 30 1.6E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS19810 831e723c85ec8200f3baabf9bbbdc80c 77 PRINTS PR00352 3Fe-4S ferredoxin signature 9 20 1.6E-6 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS14200 efd8fe4be27187d8c3d159b90b314e7a 351 Gene3D G3DSA:3.40.50.2300 175 346 1.5E-39 T 17-03-2017 SHXM_RS14200 efd8fe4be27187d8c3d159b90b314e7a 351 SUPERFAMILY SSF53822 56 346 5.22E-68 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS14200 efd8fe4be27187d8c3d159b90b314e7a 351 Gene3D G3DSA:3.40.50.2300 53 174 7.6E-31 T 17-03-2017 SHXM_RS14200 efd8fe4be27187d8c3d159b90b314e7a 351 Pfam PF13407 Periplasmic binding protein domain 59 316 1.6E-48 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 5.7E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 81 92 5.7E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 154 173 5.7E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 224 244 5.7E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 5.7E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 128 144 5.7E-37 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 81 92 1.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 154 173 1.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 134 142 1.4E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 Gene3D G3DSA:3.40.50.720 1 262 3.6E-70 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 141 169 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 261 1.5E-44 T 17-03-2017 SHXM_RS32160 87ed1a035ad29ba837a7b4546a6232ad 264 SUPERFAMILY SSF51735 7 262 9.28E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04305 8b0d871824ce2473bad59c0d862c5a73 232 SUPERFAMILY SSF53474 5 227 5.26E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04305 8b0d871824ce2473bad59c0d862c5a73 232 Gene3D G3DSA:3.40.50.1820 4 228 2.5E-39 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04305 8b0d871824ce2473bad59c0d862c5a73 232 Pfam PF12697 Alpha/beta hydrolase family 4 223 8.3E-14 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS16050 4d30d53633fa276f55aed927576437e9 380 Pfam PF09754 PAC2 family 19 237 4.0E-51 T 17-03-2017 IPR019151 Proteasome assembly chaperone 2 SHXM_RS16050 4d30d53633fa276f55aed927576437e9 380 SUPERFAMILY SSF159659 3 261 1.44E-87 T 17-03-2017 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 SUPERFAMILY SSF56645 2 247 1.44E-71 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 236 381 1.3E-27 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 Gene3D G3DSA:1.10.540.10 1 124 8.0E-28 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 SUPERFAMILY SSF47203 236 385 5.93E-17 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 Gene3D G3DSA:2.40.110.10 126 225 1.3E-32 T 17-03-2017 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 127 222 4.8E-20 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 Gene3D G3DSA:1.20.140.10 226 385 6.0E-25 T 17-03-2017 SHXM_RS31635 901dce3775302c612cf2f1603686500d 387 Pfam PF02771 Acyl-CoA dehydrogenase, N-terminal domain 6 123 6.4E-23 T 17-03-2017 IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal GO:0008152|GO:0016627|GO:0050660|GO:0055114 SHXM_RS08225 2d18bd61a21acfc0ecca6550db2dc5d5 313 SUPERFAMILY SSF161098 103 290 1.83E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08225 2d18bd61a21acfc0ecca6550db2dc5d5 313 Gene3D G3DSA:1.10.3720.10 99 306 7.9E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08225 2d18bd61a21acfc0ecca6550db2dc5d5 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 126 305 1.9E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS44990 6792a3813d376f24d3f3fd59fa26e205 68 Gene3D G3DSA:3.40.1090.10 25 66 1.4E-4 T 17-03-2017 SHXM_RS44990 6792a3813d376f24d3f3fd59fa26e205 68 SUPERFAMILY SSF52151 25 66 3.92E-10 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS44990 6792a3813d376f24d3f3fd59fa26e205 68 Pfam PF01734 Patatin-like phospholipase 25 66 8.7E-6 T 17-03-2017 IPR002641 Patatin/Phospholipase A2-related GO:0006629 SHXM_RS06070 5283cc89f055e8fa6729f476eff668f2 640 Gene3D G3DSA:3.50.50.60 553 592 1.8E-15 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06070 5283cc89f055e8fa6729f476eff668f2 640 Gene3D G3DSA:3.50.50.60 14 208 1.8E-15 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06070 5283cc89f055e8fa6729f476eff668f2 640 Pfam PF13454 FAD-NAD(P)-binding 19 201 7.1E-41 T 17-03-2017 SHXM_RS06070 5283cc89f055e8fa6729f476eff668f2 640 SUPERFAMILY SSF51905 126 252 1.07E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06070 5283cc89f055e8fa6729f476eff668f2 640 SUPERFAMILY SSF51905 14 62 1.07E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01440 d846fc9fde91eb1098213be0cfe9a32b 334 SUPERFAMILY SSF50022 48 144 3.54E-19 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS01440 d846fc9fde91eb1098213be0cfe9a32b 334 Gene3D G3DSA:2.102.10.10 50 145 1.4E-15 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS01440 d846fc9fde91eb1098213be0cfe9a32b 334 Pfam PF00355 Rieske [2Fe-2S] domain 50 123 2.1E-11 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS15295 b3dd7bffefc4ea6125e715b294084e9f 145 SUPERFAMILY SSF55961 4 132 1.97E-32 T 17-03-2017 SHXM_RS15295 b3dd7bffefc4ea6125e715b294084e9f 145 Gene3D G3DSA:3.30.530.20 4 144 1.1E-40 T 17-03-2017 IPR023393 START-like domain SHXM_RS15295 b3dd7bffefc4ea6125e715b294084e9f 145 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 8 143 2.7E-21 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS29485 071c860a7e6f9a9ba446070bff41ef2f 226 Pfam PF13419 Haloacid dehalogenase-like hydrolase 93 195 4.4E-12 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS29485 071c860a7e6f9a9ba446070bff41ef2f 226 Gene3D G3DSA:3.40.50.1000 98 221 1.1E-27 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS29485 071c860a7e6f9a9ba446070bff41ef2f 226 Gene3D G3DSA:3.40.50.1000 5 29 1.1E-27 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS29485 071c860a7e6f9a9ba446070bff41ef2f 226 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 139 196 5.5E-10 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS29485 071c860a7e6f9a9ba446070bff41ef2f 226 SUPERFAMILY SSF56784 10 222 1.37E-28 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS03120 9b79ea2076624c00171765c9688d3312 214 Gene3D G3DSA:1.10.357.10 12 199 1.8E-36 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03120 9b79ea2076624c00171765c9688d3312 214 SUPERFAMILY SSF46689 11 91 8.03E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03120 9b79ea2076624c00171765c9688d3312 214 SUPERFAMILY SSF48498 87 193 1.0E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS03120 9b79ea2076624c00171765c9688d3312 214 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 43 66 1.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03120 9b79ea2076624c00171765c9688d3312 214 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 1.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03120 9b79ea2076624c00171765c9688d3312 214 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 67 1.9E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS21550 8c360e5d8fa8af28692aed775166aa8e 600 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 509 596 3.9E-10 T 17-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain SHXM_RS21550 8c360e5d8fa8af28692aed775166aa8e 600 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 316 427 1.2E-5 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS30235 a154a62f84acfe6e57e059b0723b7cf5 1024 Gene3D G3DSA:3.80.10.10 837 965 6.1E-5 T 17-03-2017 IPR032675 Leucine-rich repeat domain, L domain-like SHXM_RS30235 a154a62f84acfe6e57e059b0723b7cf5 1024 Pfam PF05729 NACHT domain 280 441 2.7E-30 T 17-03-2017 SHXM_RS30235 a154a62f84acfe6e57e059b0723b7cf5 1024 SUPERFAMILY SSF52047 835 982 5.1E-7 T 17-03-2017 SHXM_RS30235 a154a62f84acfe6e57e059b0723b7cf5 1024 SUPERFAMILY SSF52540 274 411 8.1E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30235 a154a62f84acfe6e57e059b0723b7cf5 1024 Gene3D G3DSA:3.40.50.300 273 387 3.1E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 SUPERFAMILY SSF53335 270 317 1.06E-52 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 SUPERFAMILY SSF53335 3 235 1.06E-52 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 Pfam PF00145 C-5 cytosine-specific DNA methylase 5 172 6.3E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 Pfam PF00145 C-5 cytosine-specific DNA methylase 270 317 1.3E-9 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 155 168 5.7E-13 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 108 122 5.7E-13 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 PRINTS PR00105 Cytosine-specific DNA methyltransferase signature 5 21 5.7E-13 T 17-03-2017 IPR001525 C-5 cytosine methyltransferase GO:0008168 KEGG: 00270+2.1.1.37 SHXM_RS29725 4b69c992d90e64d4668a94f54f807423 335 Gene3D G3DSA:3.40.50.150 1 206 5.6E-37 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS17825 0238a3f8b3229e2892aab8c0424e0e62 389 Pfam PF01458 Uncharacterized protein family (UPF0051) 138 359 1.5E-70 T 17-03-2017 IPR000825 SUF system FeS cluster assembly, SufBD GO:0016226 SHXM_RS17825 0238a3f8b3229e2892aab8c0424e0e62 389 SUPERFAMILY SSF101960 33 385 4.18E-93 T 17-03-2017 SHXM_RS17825 0238a3f8b3229e2892aab8c0424e0e62 389 TIGRFAM TIGR01981 sufD: FeS assembly protein SufD 107 376 4.5E-73 T 17-03-2017 IPR011542 SUF system FeS cluster assembly, SufD GO:0016226 SHXM_RS46475 d052307ccf495168bf9b27bb6f849e49 63 SUPERFAMILY SSF56176 3 45 2.51E-9 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS46475 d052307ccf495168bf9b27bb6f849e49 63 Pfam PF01565 FAD binding domain 4 42 7.7E-6 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS46475 d052307ccf495168bf9b27bb6f849e49 63 Gene3D G3DSA:3.30.465.10 4 47 2.6E-4 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS17890 9439256d16ac862a01c58edcf84ff5e7 260 SUPERFAMILY SSF100950 6 253 1.73E-60 T 17-03-2017 SHXM_RS17890 9439256d16ac862a01c58edcf84ff5e7 260 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 11 240 6.4E-71 T 17-03-2017 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 SHXM_RS17890 9439256d16ac862a01c58edcf84ff5e7 260 Gene3D G3DSA:3.40.50.1360 4 250 9.8E-72 T 17-03-2017 SHXM_RS17890 9439256d16ac862a01c58edcf84ff5e7 260 TIGRFAM TIGR01198 pgl: 6-phosphogluconolactonase 8 248 6.1E-77 T 17-03-2017 IPR005900 6-phosphogluconolactonase, DevB-type GO:0005975|GO:0006098|GO:0017057 KEGG: 00030+3.1.1.31 SHXM_RS46215 faa66292e519aae655f507a241a42631 416 TIGRFAM TIGR02276 beta_rpt_yvtn: 40-residue YVTN family beta-propeller repeat 107 142 4.4E-9 T 17-03-2017 IPR011964 YVTN beta-propeller repeat SHXM_RS46215 faa66292e519aae655f507a241a42631 416 SUPERFAMILY SSF50974 103 402 1.41E-65 T 17-03-2017 IPR011045 Nitrous oxide reductase, N-terminal Reactome: R-HSA-114608 SHXM_RS46215 faa66292e519aae655f507a241a42631 416 Gene3D G3DSA:2.130.10.10 105 403 4.2E-59 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS46215 faa66292e519aae655f507a241a42631 416 Pfam PF10282 Lactonase, 7-bladed beta-propeller 182 387 6.0E-9 T 17-03-2017 IPR019405 Lactonase, 7-bladed beta propeller KEGG: 00030+3.1.1.31 SHXM_RS22980 ae14d4ee76bcfe403d01a03e4fa69814 169 Pfam PF12903 Protein of unknown function (DUF3830) 11 168 6.1E-64 T 17-03-2017 IPR024532 Protein of unknown function DUF3830 SHXM_RS22980 ae14d4ee76bcfe403d01a03e4fa69814 169 SUPERFAMILY SSF50891 10 154 3.79E-10 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 SMART SM00895 109 233 1.9E-16 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 Pfam PF07729 FCD domain 110 229 4.7E-20 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 SMART SM00345 22 80 4.8E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 Gene3D G3DSA:1.20.120.530 96 230 1.1E-19 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 Pfam PF00392 Bacterial regulatory proteins, gntR family 22 80 1.4E-11 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 Gene3D G3DSA:1.10.10.10 9 82 7.4E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 SUPERFAMILY SSF46785 13 84 3.59E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25000 302f8e7d85bae7a2b54f851f3c38f23c 243 SUPERFAMILY SSF48008 106 236 1.18E-20 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS08035 4cc62ede2569a2187fbabe9ea9ad2726 341 Gene3D G3DSA:3.40.109.10 126 184 1.1E-10 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS08035 4cc62ede2569a2187fbabe9ea9ad2726 341 Gene3D G3DSA:3.40.109.10 245 335 1.1E-10 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS08035 4cc62ede2569a2187fbabe9ea9ad2726 341 Gene3D G3DSA:3.40.109.30 9 92 1.3E-10 T 17-03-2017 SHXM_RS08035 4cc62ede2569a2187fbabe9ea9ad2726 341 SUPERFAMILY SSF55469 125 183 3.46E-7 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS08035 4cc62ede2569a2187fbabe9ea9ad2726 341 SUPERFAMILY SSF55469 247 328 3.46E-7 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS08035 4cc62ede2569a2187fbabe9ea9ad2726 341 SUPERFAMILY SSF55469 4 84 5.1E-9 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS15815 a4e4101e4502a15515f1a6740fd9bb36 543 SUPERFAMILY SSF140864 19 346 1.24E-44 T 17-03-2017 SHXM_RS15815 a4e4101e4502a15515f1a6740fd9bb36 543 SUPERFAMILY SSF53300 350 515 3.5E-15 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS15815 a4e4101e4502a15515f1a6740fd9bb36 543 Pfam PF05731 TROVE domain 165 327 4.9E-15 T 17-03-2017 IPR008858 TROVE domain GO:0003723 SHXM_RS40780 a8ef47e09840fbc1718a4532a7993754 278 SUPERFAMILY SSF52266 41 266 6.66E-56 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS40780 a8ef47e09840fbc1718a4532a7993754 278 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 45 266 6.6E-24 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS40780 a8ef47e09840fbc1718a4532a7993754 278 Gene3D G3DSA:3.40.50.1110 38 266 2.3E-61 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS08120 4dbd4977ba9f7f07054279c944dc9ede 315 Gene3D G3DSA:1.10.3720.10 82 311 2.9E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08120 4dbd4977ba9f7f07054279c944dc9ede 315 SUPERFAMILY SSF161098 76 301 1.83E-43 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08120 4dbd4977ba9f7f07054279c944dc9ede 315 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 313 3.6E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS41250 5ac639aab04fe11713c75fe60e643f6a 204 Gene3D G3DSA:3.40.430.10 3 203 6.3E-28 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS41250 5ac639aab04fe11713c75fe60e643f6a 204 SUPERFAMILY SSF53597 4 201 4.84E-21 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS41250 5ac639aab04fe11713c75fe60e643f6a 204 Pfam PF01872 RibD C-terminal domain 4 198 2.0E-16 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS27885 5a4c2ad0162530a70176ca97142fba62 210 SUPERFAMILY SSF50475 25 150 4.29E-16 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS27885 5a4c2ad0162530a70176ca97142fba62 210 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 26 117 1.9E-13 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS27885 5a4c2ad0162530a70176ca97142fba62 210 Gene3D G3DSA:2.30.110.10 16 148 6.0E-25 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS39040 39e91669d9d02304ac1b78022e1040f2 276 SUPERFAMILY SSF51219 4 258 2.56E-47 T 17-03-2017 IPR016031 Tryptophan RNA-binding attenuator protein-like domain SHXM_RS39040 39e91669d9d02304ac1b78022e1040f2 276 Pfam PF01987 Mitochondrial biogenesis AIM24 6 245 2.0E-51 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS39040 39e91669d9d02304ac1b78022e1040f2 276 Gene3D G3DSA:3.60.160.10 4 269 1.1E-70 T 17-03-2017 IPR002838 Mitochondrial biogenesis protein AIM24 SHXM_RS30065 eb1ba7b919fdb817cdc554e585355156 158 SUPERFAMILY SSF46785 6 134 1.0E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30065 eb1ba7b919fdb817cdc554e585355156 158 Gene3D G3DSA:1.10.10.10 5 82 3.1E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30065 eb1ba7b919fdb817cdc554e585355156 158 Pfam PF01475 Ferric uptake regulator family 12 120 1.4E-23 T 17-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SHXM_RS07525 357af020439becb4d69adc63ab22df62 326 SUPERFAMILY SSF53807 43 312 3.92E-55 T 17-03-2017 SHXM_RS07525 357af020439becb4d69adc63ab22df62 326 Gene3D G3DSA:3.40.50.1980 168 324 3.4E-34 T 17-03-2017 SHXM_RS07525 357af020439becb4d69adc63ab22df62 326 Pfam PF01497 Periplasmic binding protein 66 301 2.8E-28 T 17-03-2017 IPR002491 ABC transporter periplasmic binding domain GO:0005488 SHXM_RS07525 357af020439becb4d69adc63ab22df62 326 Gene3D G3DSA:3.40.50.1980 46 167 1.3E-29 T 17-03-2017 SHXM_RS06340 2f8602fc1a35f4a77a395ee632f37585 222 Pfam PF03713 Domain of unknown function (DUF305) 64 219 5.2E-50 T 17-03-2017 IPR005183 Domain of unknown function DUF305 SHXM_RS06340 2f8602fc1a35f4a77a395ee632f37585 222 Gene3D G3DSA:1.20.1260.10 59 221 1.0E-58 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS44725 29db96e7ff6b669016fd0fd70c757003 188 Gene3D G3DSA:1.10.443.10 44 167 1.8E-8 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS44725 29db96e7ff6b669016fd0fd70c757003 188 Pfam PF00589 Phage integrase family 42 180 1.2E-6 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS44725 29db96e7ff6b669016fd0fd70c757003 188 SUPERFAMILY SSF56349 44 167 7.06E-10 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS31410 8b35b30f0a4bd29c9843bd0eb5f99815 378 Gene3D G3DSA:3.40.50.1100 60 158 1.5E-20 T 17-03-2017 SHXM_RS31410 8b35b30f0a4bd29c9843bd0eb5f99815 378 SUPERFAMILY SSF53686 28 334 7.99E-64 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS31410 8b35b30f0a4bd29c9843bd0eb5f99815 378 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 30 313 3.0E-47 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS31410 8b35b30f0a4bd29c9843bd0eb5f99815 378 Gene3D G3DSA:3.40.50.1100 159 324 2.2E-36 T 17-03-2017 SHXM_RS15280 d0fb3112000849afa2f25382d982222f 221 Gene3D G3DSA:3.40.50.720 1 211 3.1E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15280 d0fb3112000849afa2f25382d982222f 221 Pfam PF13460 NAD(P)H-binding 7 194 2.2E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15280 d0fb3112000849afa2f25382d982222f 221 SUPERFAMILY SSF51735 1 209 2.59E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS26485 7b60859129e58b0bd0aa54ea135114a6 235 Pfam PF09335 SNARE associated Golgi protein 41 168 2.0E-26 T 17-03-2017 IPR032816 SNARE associated Golgi protein SHXM_RS16555 66c7f9c676f9c8e6cfefca3699499b00 367 SUPERFAMILY SSF55729 144 319 5.3E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS16555 66c7f9c676f9c8e6cfefca3699499b00 367 Pfam PF13480 Acetyltransferase (GNAT) domain 160 301 5.5E-39 T 17-03-2017 SHXM_RS03750 96d5f187057da1ad2f1c5e8fdb7fa61c 321 Pfam PF01040 UbiA prenyltransferase family 17 243 8.7E-37 T 17-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 SUPERFAMILY SSF47413 14 72 1.31E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 SMART SM00354 14 84 1.3E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 Gene3D G3DSA:1.10.260.40 15 66 2.7E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 Gene3D G3DSA:3.40.50.2300 190 323 8.1E-45 T 17-03-2017 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 Gene3D G3DSA:3.40.50.2300 67 189 8.1E-23 T 17-03-2017 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 SUPERFAMILY SSF53822 89 347 2.36E-54 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 Pfam PF13377 Periplasmic binding protein-like domain 186 343 5.9E-41 T 17-03-2017 SHXM_RS50195 3c16c652fe3b5ab72f09a3969b6b241e 354 Pfam PF00356 Bacterial regulatory proteins, lacI family 17 61 2.7E-12 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS29105 f6c43a89d33a826d0b48d696ab3edeaf 123 Gene3D G3DSA:2.60.120.10 26 107 6.0E-8 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS29105 f6c43a89d33a826d0b48d696ab3edeaf 123 SUPERFAMILY SSF51182 17 107 5.08E-8 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 Gene3D G3DSA:1.10.10.10 6 88 1.6E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 SUPERFAMILY SSF46785 6 113 2.41E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 Gene3D G3DSA:3.40.190.10 92 180 7.4E-19 T 17-03-2017 SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 SUPERFAMILY SSF53850 89 299 2.58E-38 T 17-03-2017 SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 Gene3D G3DSA:3.40.190.10 181 266 7.7E-21 T 17-03-2017 SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 63 2.0E-15 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40630 292768da5d142669f1f5f1a3ffa16746 320 Pfam PF03466 LysR substrate binding domain 89 296 2.3E-41 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS34740 ba3003d1605cc07611fbe0194e0e71f7 164 Pfam PF00717 Peptidase S24-like 27 88 3.4E-11 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS34740 ba3003d1605cc07611fbe0194e0e71f7 164 TIGRFAM TIGR02754 sod_Ni_protease: nickel-type superoxide dismutase maturation protease 27 107 4.3E-21 T 17-03-2017 IPR014124 Peptidase S26A, superoxide dismutase maturation protease, nickel-type SHXM_RS34740 ba3003d1605cc07611fbe0194e0e71f7 164 Gene3D G3DSA:2.10.109.10 25 116 6.9E-19 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS34740 ba3003d1605cc07611fbe0194e0e71f7 164 SUPERFAMILY SSF51306 25 119 5.49E-22 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS45715 dbd23d88da01ca0730a563ab879e569f 885 Pfam PF08531 Alpha-L-rhamnosidase N-terminal domain 162 328 3.7E-53 T 17-03-2017 IPR013737 Bacterial alpha-L-rhamnosidase N-terminal SHXM_RS45715 dbd23d88da01ca0730a563ab879e569f 885 Gene3D G3DSA:2.60.40.10 93 129 2.9E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS45715 dbd23d88da01ca0730a563ab879e569f 885 Pfam PF05592 Bacterial alpha-L-rhamnosidase 337 843 2.1E-134 T 17-03-2017 IPR008902 Bacterial alpha-L-rhamnosidase SHXM_RS45715 dbd23d88da01ca0730a563ab879e569f 885 PIRSF PIRSF010631 1 885 7.5E-260 T 17-03-2017 IPR016007 Alpha-L-rhamnosidase SHXM_RS45715 dbd23d88da01ca0730a563ab879e569f 885 SUPERFAMILY SSF48208 441 848 9.52E-40 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS45715 dbd23d88da01ca0730a563ab879e569f 885 Gene3D G3DSA:2.60.120.260 327 442 5.0E-20 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS15760 902e286cc4e0673fdd8b81b5102f2bde 727 Gene3D G3DSA:3.40.50.300 1 155 5.6E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15760 902e286cc4e0673fdd8b81b5102f2bde 727 Gene3D G3DSA:3.40.50.300 247 412 5.6E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15760 902e286cc4e0673fdd8b81b5102f2bde 727 SUPERFAMILY SSF52540 208 401 1.0E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15760 902e286cc4e0673fdd8b81b5102f2bde 727 SUPERFAMILY SSF52540 1 143 1.0E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15760 902e286cc4e0673fdd8b81b5102f2bde 727 Pfam PF13175 AAA ATPase domain 1 397 9.6E-36 T 17-03-2017 SHXM_RS37965 d8f66fe0a1c19210f263ac1fd567a298 731 SUPERFAMILY SSF48371 447 552 2.4E-5 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 SUPERFAMILY SSF46785 5 115 6.22E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 Pfam PF03466 LysR substrate binding domain 95 290 9.9E-44 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 Gene3D G3DSA:1.10.10.10 6 89 4.2E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 33 43 4.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 22 33 4.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 43 54 4.2E-5 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 Gene3D G3DSA:3.40.190.10 96 179 3.7E-16 T 17-03-2017 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 7 66 4.3E-17 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 SUPERFAMILY SSF53850 96 291 6.77E-40 T 17-03-2017 SHXM_RS48275 6a3dda35a158f11fa44d2d60309cd388 302 Gene3D G3DSA:3.40.190.10 180 267 9.8E-22 T 17-03-2017 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 SMART SM00448 2 115 9.5E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 SUPERFAMILY SSF52172 2 133 5.69E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 176 188 1.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 146 160 1.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 160 176 1.1E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 ProSitePatterns PS00622 LuxR-type HTH domain signature. 160 187 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 SUPERFAMILY SSF46894 129 206 2.01E-21 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 Pfam PF00072 Response regulator receiver domain 4 116 1.7E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 Gene3D G3DSA:1.10.10.10 121 206 1.7E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 Pfam PF00196 Bacterial regulatory proteins, luxR family 145 199 1.2E-16 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 Gene3D G3DSA:3.40.50.2300 2 120 3.7E-36 T 17-03-2017 SHXM_RS12490 7a73f94474d19d13e69a4b17eed02feb 206 SMART SM00421 143 200 5.6E-23 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 156 175 1.5E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 175 192 1.5E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 72 83 1.5E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 120 136 1.5E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 3 20 1.5E-24 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 72 83 9.4E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 175 9.4E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 126 134 9.4E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 143 171 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 Pfam PF00106 short chain dehydrogenase 4 196 2.8E-41 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 SUPERFAMILY SSF51735 4 231 6.71E-55 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16650 05b555e050c19bc51a8ab9b99a4a80eb 232 Gene3D G3DSA:3.40.50.720 2 228 4.3E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13645 a90459e27cf43c57c133b570964649da 150 Pfam PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region 7 97 4.0E-7 T 17-03-2017 IPR002125 Cytidine and deoxycytidylate deaminases, zinc-binding GO:0008270 SHXM_RS13645 a90459e27cf43c57c133b570964649da 150 SUPERFAMILY SSF53927 8 132 1.56E-25 T 17-03-2017 IPR016193 Cytidine deaminase-like GO:0003824 SHXM_RS13645 a90459e27cf43c57c133b570964649da 150 Gene3D G3DSA:3.40.140.10 8 133 4.8E-28 T 17-03-2017 SHXM_RS13645 a90459e27cf43c57c133b570964649da 150 ProSitePatterns PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 55 96 - T 17-03-2017 IPR016192 APOBEC/CMP deaminase, zinc-binding GO:0008270|GO:0016787 SHXM_RS47195 f3fb76e70159338c7867f7f22ce2fb65 218 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 2 49 6.3E-16 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 25 120 8.6E-19 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 SUPERFAMILY SSF51735 124 285 2.03E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 Gene3D G3DSA:3.40.50.720 157 265 1.2E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 Pfam PF00107 Zinc-binding dehydrogenase 163 281 8.2E-18 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 Gene3D G3DSA:3.90.180.10 1 156 1.6E-37 T 17-03-2017 IPR011032 GroES-like SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 SUPERFAMILY SSF50129 1 160 5.17E-38 T 17-03-2017 IPR011032 GroES-like SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 SMART SM00829 10 315 6.7E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS47020 8108cdd82fb6dcff76f111370f0b9829 319 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 60 74 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS00700 9d9e331025938559ba836dfd2af4e723 209 SUPERFAMILY SSF48498 90 204 1.29E-18 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS00700 9d9e331025938559ba836dfd2af4e723 209 SUPERFAMILY SSF46689 18 94 4.21E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00700 9d9e331025938559ba836dfd2af4e723 209 Pfam PF00440 Bacterial regulatory proteins, tetR family 27 72 2.4E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS00700 9d9e331025938559ba836dfd2af4e723 209 Gene3D G3DSA:1.10.357.10 23 204 4.3E-30 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS00700 9d9e331025938559ba836dfd2af4e723 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 27 40 8.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS00700 9d9e331025938559ba836dfd2af4e723 209 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 48 71 8.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS13960 f4cd445a64dacb7e6faaf4aecf746b63 419 Gene3D G3DSA:3.40.50.2300 118 210 1.9E-6 T 17-03-2017 SHXM_RS13960 f4cd445a64dacb7e6faaf4aecf746b63 419 Pfam PF01513 ATP-NAD kinase 104 416 1.2E-41 T 17-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS13960 f4cd445a64dacb7e6faaf4aecf746b63 419 SUPERFAMILY SSF111331 135 185 6.32E-9 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS28715 482c67d0ab5fff6d3a3d546be76ed908 599 SMART SM00637 499 597 3.0E-32 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS28715 482c67d0ab5fff6d3a3d546be76ed908 599 Pfam PF00553 Cellulose binding domain 499 597 2.8E-25 T 17-03-2017 IPR001919 Carbohydrate-binding type-2 domain GO:0004553|GO:0005975|GO:0030246 SHXM_RS28715 482c67d0ab5fff6d3a3d546be76ed908 599 SUPERFAMILY SSF49384 497 597 4.74E-27 T 17-03-2017 IPR008965 Carbohydrate-binding domain GO:0030246 SHXM_RS28715 482c67d0ab5fff6d3a3d546be76ed908 599 Gene3D G3DSA:2.60.40.290 498 598 9.9E-31 T 17-03-2017 IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain GO:0004553|GO:0030247 SHXM_RS50210 07700f7894c04baf85cebc171bde487e 285 Gene3D G3DSA:1.10.3720.10 10 272 3.7E-61 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50210 07700f7894c04baf85cebc171bde487e 285 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 276 8.7E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50210 07700f7894c04baf85cebc171bde487e 285 SUPERFAMILY SSF161098 9 284 2.9E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04690 836b5d4a090123068257b4687cd5e112 269 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 93 263 1.7E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04690 836b5d4a090123068257b4687cd5e112 269 SUPERFAMILY SSF161098 69 255 1.03E-35 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04690 836b5d4a090123068257b4687cd5e112 269 Gene3D G3DSA:1.10.3720.10 68 263 4.9E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31480 059a78e445cae3a90bb89e930450c498 288 Pfam PF01522 Polysaccharide deacetylase 63 174 6.5E-12 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS31480 059a78e445cae3a90bb89e930450c498 288 Gene3D G3DSA:3.20.20.370 5 282 2.7E-65 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS31480 059a78e445cae3a90bb89e930450c498 288 SUPERFAMILY SSF88713 5 282 7.34E-62 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 110 288 1.1E-46 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 SUPERFAMILY SSF52283 27 133 9.64E-8 T 17-03-2017 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 148 166 7.6E-6 T 17-03-2017 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 33 52 7.6E-6 T 17-03-2017 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 202 218 7.6E-6 T 17-03-2017 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 Gene3D G3DSA:3.40.50.720 103 289 1.6E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 148 173 8.8E-5 T 17-03-2017 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 230 244 8.8E-5 T 17-03-2017 SHXM_RS02825 268f3e9e76379ad23f3012856da4926a 325 SUPERFAMILY SSF51735 104 289 1.85E-46 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 Gene3D G3DSA:3.20.20.140 55 325 2.9E-60 T 17-03-2017 SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 Gene3D G3DSA:2.30.40.10 26 54 1.5E-9 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 Gene3D G3DSA:2.30.40.10 326 363 1.5E-9 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 Pfam PF01979 Amidohydrolase family 50 363 8.6E-14 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 SUPERFAMILY SSF51556 53 327 2.72E-59 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 SUPERFAMILY SSF51338 4 52 1.2E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS17560 4e9e520c35480d15b61eb11e965b99a9 364 SUPERFAMILY SSF51338 326 363 1.2E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS31095 492f90c8ce757bf744a61fd6c03cfbd6 276 SUPERFAMILY SSF89392 150 260 2.51E-10 T 17-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX SHXM_RS38890 f2e06d143b5454d2e93eab13174b9eb3 81 Gene3D G3DSA:2.80.10.50 48 80 8.1E-9 T 17-03-2017 SHXM_RS38890 f2e06d143b5454d2e93eab13174b9eb3 81 SUPERFAMILY SSF50370 47 80 8.35E-11 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS23560 186cfdb6f72501fdc9823f9ce4799543 480 Gene3D G3DSA:1.20.1250.20 17 198 6.2E-16 T 17-03-2017 SHXM_RS23560 186cfdb6f72501fdc9823f9ce4799543 480 SUPERFAMILY SSF103473 11 412 1.31E-48 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23560 186cfdb6f72501fdc9823f9ce4799543 480 Gene3D G3DSA:1.20.1250.20 232 411 1.5E-20 T 17-03-2017 SHXM_RS23560 186cfdb6f72501fdc9823f9ce4799543 480 Pfam PF07690 Major Facilitator Superfamily 242 423 1.5E-22 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23560 186cfdb6f72501fdc9823f9ce4799543 480 ProSitePatterns PS00216 Sugar transport proteins signature 1. 73 89 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 Gene3D G3DSA:1.20.1250.20 14 194 2.6E-29 T 17-03-2017 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 Gene3D G3DSA:1.20.1250.20 263 457 3.5E-23 T 17-03-2017 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 SUPERFAMILY SSF103473 8 198 1.83E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 SUPERFAMILY SSF103473 248 457 1.83E-69 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 Pfam PF07690 Major Facilitator Superfamily 21 410 2.8E-51 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 15 419 8.7E-89 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 PRINTS PR01036 Tetracycline resistance protein TetB signature 18 42 7.2E-8 T 17-03-2017 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 PRINTS PR01036 Tetracycline resistance protein TetB signature 109 129 7.2E-8 T 17-03-2017 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 PRINTS PR01036 Tetracycline resistance protein TetB signature 139 163 7.2E-8 T 17-03-2017 SHXM_RS13390 ba27ceb75b597dba9460a9f815203086 487 PRINTS PR01036 Tetracycline resistance protein TetB signature 203 221 7.2E-8 T 17-03-2017 SHXM_RS47485 1cdf1b0a0a3816a4576e47c62eacd633 198 SUPERFAMILY SSF52499 5 195 5.63E-41 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS47485 1cdf1b0a0a3816a4576e47c62eacd633 198 Gene3D G3DSA:3.40.50.850 7 194 3.4E-41 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS47485 1cdf1b0a0a3816a4576e47c62eacd633 198 Pfam PF00857 Isochorismatase family 14 190 1.2E-29 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS31495 4cbfbe2675973438b2d3308630c89b02 455 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 250 331 4.1E-7 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 Gene3D G3DSA:3.40.50.10490 23 99 8.2E-67 T 17-03-2017 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 Gene3D G3DSA:3.40.50.10490 159 245 8.2E-67 T 17-03-2017 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 ProSitePatterns PS00962 Ribosomal protein S2 signature 1. 6 17 - T 17-03-2017 IPR018130 Ribosomal protein S2, conserved site GO:0003735|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 PRINTS PR00395 Ribosomal protein S2 signature 176 187 5.9E-38 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 PRINTS PR00395 Ribosomal protein S2 signature 6 24 5.9E-38 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 PRINTS PR00395 Ribosomal protein S2 signature 37 46 5.9E-38 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 PRINTS PR00395 Ribosomal protein S2 signature 159 176 5.9E-38 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 PRINTS PR00395 Ribosomal protein S2 signature 87 104 5.9E-38 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 PRINTS PR00395 Ribosomal protein S2 signature 197 211 5.9E-38 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 Hamap MF_00291_B 30S ribosomal protein S2 [rpsB]. 2 226 41.992 T 17-03-2017 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 Gene3D G3DSA:1.10.287.610 100 153 4.2E-21 T 17-03-2017 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 SUPERFAMILY SSF52313 6 233 5.89E-90 T 17-03-2017 IPR023591 Ribosomal protein S2, flavodoxin-like domain SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 TIGRFAM TIGR01011 rpsB_bact: ribosomal protein uS2 3 225 8.8E-107 T 17-03-2017 IPR005706 Ribosomal protein S2, bacteria/mitochondria/plastid GO:0003735|GO:0006412|GO:0015935 SHXM_RS36655 d3fa99eff4b5470f3e42f13c8a239d50 321 Pfam PF00318 Ribosomal protein S2 9 225 4.2E-95 T 17-03-2017 IPR001865 Ribosomal protein S2 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS17010 d900602c25b6ebe792a1ebb71be38e91 319 SUPERFAMILY SSF46785 4 62 6.98E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17010 d900602c25b6ebe792a1ebb71be38e91 319 Pfam PF13280 WYL domain 142 310 4.5E-28 T 17-03-2017 IPR026881 WYL domain SHXM_RS17010 d900602c25b6ebe792a1ebb71be38e91 319 ProSitePatterns PS00894 DeoR-type HTH domain signature. 7 41 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS17010 d900602c25b6ebe792a1ebb71be38e91 319 SMART SM00420 7 63 0.0074 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS17010 d900602c25b6ebe792a1ebb71be38e91 319 Gene3D G3DSA:1.10.10.10 6 66 1.4E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17010 d900602c25b6ebe792a1ebb71be38e91 319 Pfam PF08279 HTH domain 7 62 5.9E-16 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS05205 c371b195f9d6d56deae2ab5743272a7f 799 Gene3D G3DSA:2.80.10.50 666 798 9.9E-25 T 17-03-2017 SHXM_RS05205 c371b195f9d6d56deae2ab5743272a7f 799 SUPERFAMILY SSF48208 87 360 9.64E-14 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS05205 c371b195f9d6d56deae2ab5743272a7f 799 Pfam PF14200 Ricin-type beta-trefoil lectin domain-like 701 786 3.6E-18 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS05205 c371b195f9d6d56deae2ab5743272a7f 799 SUPERFAMILY SSF50370 664 798 2.84E-37 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS05205 c371b195f9d6d56deae2ab5743272a7f 799 Pfam PF07944 Beta-L-arabinofuranosidase, GH127 99 538 2.4E-68 T 17-03-2017 IPR012878 Beta-L-arabinofuranosidase, GH127 KEGG: 00511+3.2.1.18|KEGG: 00600+3.2.1.18 SHXM_RS50920 2664b0ce224151ae29fe56fcc4fa59fa 427 Pfam PF13401 AAA domain 214 328 1.1E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS50920 2664b0ce224151ae29fe56fcc4fa59fa 427 Gene3D G3DSA:3.40.50.300 199 303 1.0E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50920 2664b0ce224151ae29fe56fcc4fa59fa 427 SUPERFAMILY SSF52540 199 365 3.81E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14150 79bb216f94148eabf6dafabffcde6fcc 392 SUPERFAMILY SSF51658 15 252 1.44E-26 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14150 79bb216f94148eabf6dafabffcde6fcc 392 Pfam PF01261 Xylose isomerase-like TIM barrel 56 235 6.9E-11 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14150 79bb216f94148eabf6dafabffcde6fcc 392 Gene3D G3DSA:3.20.20.150 49 234 2.3E-16 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14150 79bb216f94148eabf6dafabffcde6fcc 392 ProSitePatterns PS00730 AP endonucleases family 2 signature 2. 212 219 - T 17-03-2017 IPR018246 AP endonuclease 2, zinc binding site GO:0008270 SHXM_RS20040 30f810acefb83fd2dc29a07cb5c8e570 211 Gene3D G3DSA:3.40.50.1240 9 195 2.2E-19 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS20040 30f810acefb83fd2dc29a07cb5c8e570 211 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 10 178 2.5E-20 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS20040 30f810acefb83fd2dc29a07cb5c8e570 211 SMART SM00855 9 149 9.1E-5 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS20040 30f810acefb83fd2dc29a07cb5c8e570 211 SUPERFAMILY SSF53254 10 201 1.83E-28 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS17700 edf4fb10b94b72910610511b0691eb74 74 SUPERFAMILY SSF51338 6 52 5.86E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS17700 edf4fb10b94b72910610511b0691eb74 74 Pfam PF01979 Amidohydrolase family 6 51 5.8E-7 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS17700 edf4fb10b94b72910610511b0691eb74 74 Gene3D G3DSA:2.30.40.10 6 65 2.0E-15 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS40370 3fae1879df505953b68eb1311aa57287 422 Gene3D G3DSA:3.40.190.10 161 354 1.9E-39 T 17-03-2017 SHXM_RS40370 3fae1879df505953b68eb1311aa57287 422 Pfam PF01547 Bacterial extracellular solute-binding protein 49 336 2.1E-45 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS40370 3fae1879df505953b68eb1311aa57287 422 SUPERFAMILY SSF53850 33 410 1.4E-70 T 17-03-2017 SHXM_RS40370 3fae1879df505953b68eb1311aa57287 422 Gene3D G3DSA:3.40.190.10 39 160 9.3E-22 T 17-03-2017 SHXM_RS27870 44c01293eaae4fda25d7744c8612ed9f 379 Gene3D G3DSA:3.40.640.10 5 246 3.6E-68 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS27870 44c01293eaae4fda25d7744c8612ed9f 379 SUPERFAMILY SSF53383 35 371 7.69E-87 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS27870 44c01293eaae4fda25d7744c8612ed9f 379 Gene3D G3DSA:3.90.1150.10 247 373 3.1E-29 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS27870 44c01293eaae4fda25d7744c8612ed9f 379 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 38 370 2.9E-82 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS27870 44c01293eaae4fda25d7744c8612ed9f 379 PIRSF PIRSF001434 2 374 7.8E-106 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS14820 8b8b0704f0b5e476951c6a9e3e232747 349 Pfam PF07728 AAA domain (dynein-related subfamily) 97 223 7.8E-8 T 17-03-2017 IPR011704 ATPase, dynein-related, AAA domain GO:0005524|GO:0016887 SHXM_RS14820 8b8b0704f0b5e476951c6a9e3e232747 349 SUPERFAMILY SSF52540 87 302 7.87E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14820 8b8b0704f0b5e476951c6a9e3e232747 349 SMART SM00382 93 320 3.0E-7 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14820 8b8b0704f0b5e476951c6a9e3e232747 349 Gene3D G3DSA:3.40.50.300 86 292 5.0E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49805 fcc02530a2015eea81a4b6bb91507817 307 Gene3D G3DSA:2.60.120.330 72 301 2.5E-25 T 17-03-2017 IPR027443 Isopenicillin N synthase-like SHXM_RS49805 fcc02530a2015eea81a4b6bb91507817 307 Pfam PF03171 2OG-Fe(II) oxygenase superfamily 167 260 3.2E-9 T 17-03-2017 IPR005123 Oxoglutarate/iron-dependent dioxygenase GO:0016491|GO:0055114 SHXM_RS49805 fcc02530a2015eea81a4b6bb91507817 307 SUPERFAMILY SSF51197 41 270 1.51E-25 T 17-03-2017 SHXM_RS24320 2287db6943098452ca675fe9fa3f7a53 175 Pfam PF04138 GtrA-like protein 23 143 7.4E-22 T 17-03-2017 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 SHXM_RS31985 77ac7de14a8fceb2b4b360148cee1c01 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 49 72 2.3E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31985 77ac7de14a8fceb2b4b360148cee1c01 199 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 28 41 2.3E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31985 77ac7de14a8fceb2b4b360148cee1c01 199 SUPERFAMILY SSF46689 17 84 3.08E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS31985 77ac7de14a8fceb2b4b360148cee1c01 199 Gene3D G3DSA:1.10.357.10 5 195 8.5E-37 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS31985 77ac7de14a8fceb2b4b360148cee1c01 199 Pfam PF00440 Bacterial regulatory proteins, tetR family 28 74 1.8E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS31985 77ac7de14a8fceb2b4b360148cee1c01 199 SUPERFAMILY SSF48498 93 196 1.51E-10 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS40910 5175ccdf2e4c8a85f182102cb41f3b24 276 Gene3D G3DSA:3.20.20.150 8 265 3.1E-73 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS40910 5175ccdf2e4c8a85f182102cb41f3b24 276 Pfam PF01261 Xylose isomerase-like TIM barrel 25 227 4.8E-33 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS40910 5175ccdf2e4c8a85f182102cb41f3b24 276 PIRSF PIRSF006241 3 270 5.9E-72 T 17-03-2017 IPR026040 Hydroxypyruvate isomerase-like KEGG: 00630+5.3.1.22 SHXM_RS40910 5175ccdf2e4c8a85f182102cb41f3b24 276 SUPERFAMILY SSF51658 7 264 2.23E-62 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS43965 676f6193c18f4a0714c56b5fb7c0a372 122 Pfam PF05239 PRC-barrel domain 25 89 2.4E-11 T 17-03-2017 IPR027275 PRC-barrel domain SHXM_RS43965 676f6193c18f4a0714c56b5fb7c0a372 122 SUPERFAMILY SSF50346 20 120 7.38E-25 T 17-03-2017 IPR011033 PRC-barrel-like SHXM_RS43965 676f6193c18f4a0714c56b5fb7c0a372 122 Gene3D G3DSA:2.30.30.240 25 81 4.5E-5 T 17-03-2017 SHXM_RS18140 b95a3efabd9daf186dcf813f02856d66 171 TIGRFAM TIGR00369 unchar_dom_1: uncharacterized domain 1 37 146 1.7E-30 T 17-03-2017 IPR003736 Phenylacetic acid degradation-related domain Reactome: R-HSA-75105 SHXM_RS18140 b95a3efabd9daf186dcf813f02856d66 171 SUPERFAMILY SSF54637 32 150 5.65E-28 T 17-03-2017 IPR029069 HotDog domain SHXM_RS18140 b95a3efabd9daf186dcf813f02856d66 171 Pfam PF03061 Thioesterase superfamily 62 139 1.9E-17 T 17-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 SHXM_RS18140 b95a3efabd9daf186dcf813f02856d66 171 Gene3D G3DSA:3.10.129.10 23 148 1.9E-46 T 17-03-2017 IPR029069 HotDog domain SHXM_RS13610 190da5c8d2af4ec9d81446a940c901fe 489 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 276 287 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS13610 190da5c8d2af4ec9d81446a940c901fe 489 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 248 255 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS13610 190da5c8d2af4ec9d81446a940c901fe 489 SUPERFAMILY SSF53720 3 480 1.96E-161 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS13610 190da5c8d2af4ec9d81446a940c901fe 489 Pfam PF00171 Aldehyde dehydrogenase family 18 476 5.6E-163 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS13610 190da5c8d2af4ec9d81446a940c901fe 489 Gene3D G3DSA:3.40.309.10 263 442 5.2E-68 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS13610 190da5c8d2af4ec9d81446a940c901fe 489 Gene3D G3DSA:3.40.605.10 3 262 1.1E-89 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS46345 9d1d30d7b4e406bf487f94274092ac2a 492 Gene3D G3DSA:3.40.605.10 18 275 2.5E-92 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS46345 9d1d30d7b4e406bf487f94274092ac2a 492 Pfam PF00171 Aldehyde dehydrogenase family 25 484 1.5E-153 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS46345 9d1d30d7b4e406bf487f94274092ac2a 492 Gene3D G3DSA:3.40.309.10 276 460 2.0E-63 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS46345 9d1d30d7b4e406bf487f94274092ac2a 492 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 261 268 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS46345 9d1d30d7b4e406bf487f94274092ac2a 492 SUPERFAMILY SSF53720 13 488 1.06E-155 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS29765 bf3661cbf86074a30bde8e156110558f 366 Gene3D G3DSA:3.40.50.300 9 189 4.9E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29765 bf3661cbf86074a30bde8e156110558f 366 Gene3D G3DSA:3.40.50.300 190 359 2.3E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29765 bf3661cbf86074a30bde8e156110558f 366 SUPERFAMILY SSF52540 7 346 6.29E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30145 b699e9d2558610615d467066c469859c 246 SUPERFAMILY SSF52172 9 133 1.85E-43 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS30145 b699e9d2558610615d467066c469859c 246 SMART SM00448 11 122 4.5E-42 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30145 b699e9d2558610615d467066c469859c 246 SUPERFAMILY SSF46894 141 239 2.78E-31 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS30145 b699e9d2558610615d467066c469859c 246 Gene3D G3DSA:1.10.10.10 142 240 2.6E-35 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30145 b699e9d2558610615d467066c469859c 246 Pfam PF00486 Transcriptional regulatory protein, C terminal 163 238 1.9E-26 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS30145 b699e9d2558610615d467066c469859c 246 Gene3D G3DSA:3.40.50.2300 9 132 2.6E-41 T 17-03-2017 SHXM_RS30145 b699e9d2558610615d467066c469859c 246 Pfam PF00072 Response regulator receiver domain 13 123 4.4E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS30145 b699e9d2558610615d467066c469859c 246 SMART SM00862 163 238 1.0E-27 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS38620 4378ee80eec48318e171dcbb04ad9533 377 SUPERFAMILY SSF144052 21 330 7.59E-15 T 17-03-2017 SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 29 185 2.6E-36 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 Gene3D G3DSA:2.10.109.10 41 101 4.9E-28 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 Gene3D G3DSA:2.10.109.10 139 192 4.9E-28 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 SUPERFAMILY SSF51306 42 191 2.25E-38 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 139 158 4.0E-19 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 91 103 4.0E-19 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 41 57 4.0E-19 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36610 0795e7923362ffbbbb8e4275edb4f82e 256 Pfam PF00717 Peptidase S24-like 47 117 8.1E-14 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS12110 0ca3440d2c59ffe95e578ce0e6052c9c 473 Pfam PF13529 Peptidase_C39 like family 260 411 4.9E-28 T 17-03-2017 SHXM_RS40580 19222d1387ee97402399596cc8054082 144 Gene3D G3DSA:3.10.180.10 7 143 1.4E-6 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS40580 19222d1387ee97402399596cc8054082 144 SUPERFAMILY SSF54593 7 143 1.13E-7 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 SUPERFAMILY SSF48498 81 189 3.34E-17 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 SUPERFAMILY SSF46689 9 77 1.08E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 ProSitePatterns PS01081 TetR-type HTH domain signature. 32 62 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 8.6E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 8.6E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 66 9.2E-20 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 Gene3D G3DSA:1.10.357.10 73 189 6.3E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS04110 9b788e805fa7b411aff6f4d71b5c0f3b 197 Gene3D G3DSA:1.10.10.60 8 66 1.2E-23 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 PRINTS PR01036 Tetracycline resistance protein TetB signature 393 412 5.0E-10 T 17-03-2017 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 PRINTS PR01036 Tetracycline resistance protein TetB signature 131 155 5.0E-10 T 17-03-2017 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 PRINTS PR01036 Tetracycline resistance protein TetB signature 9 33 5.0E-10 T 17-03-2017 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 PRINTS PR01036 Tetracycline resistance protein TetB signature 295 319 5.0E-10 T 17-03-2017 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 Gene3D G3DSA:1.20.1250.20 258 447 1.8E-21 T 17-03-2017 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 Gene3D G3DSA:1.20.1250.20 4 181 2.4E-28 T 17-03-2017 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 Pfam PF07690 Major Facilitator Superfamily 11 402 4.9E-55 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 8 411 2.3E-71 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 SUPERFAMILY SSF103473 2 190 1.57E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS03080 c86999143c8a3b13722676ee5c7de36b 459 SUPERFAMILY SSF103473 241 449 1.57E-67 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS50235 64f3d61528fa0be43dc911dc3ab9054f 153 Pfam PF00975 Thioesterase domain 15 96 1.7E-12 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS50235 64f3d61528fa0be43dc911dc3ab9054f 153 SUPERFAMILY SSF53474 13 147 7.12E-14 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS50235 64f3d61528fa0be43dc911dc3ab9054f 153 Gene3D G3DSA:3.40.50.1820 6 90 2.8E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42340 61578c1182e403ea888a390d4f398434 170 Gene3D G3DSA:1.10.3300.10 2 165 5.3E-32 T 17-03-2017 IPR023286 ABATE domain SHXM_RS42340 61578c1182e403ea888a390d4f398434 170 Pfam PF11706 CGNR zinc finger 121 164 8.2E-17 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS42340 61578c1182e403ea888a390d4f398434 170 SUPERFAMILY SSF160904 2 163 1.1E-28 T 17-03-2017 SHXM_RS13165 6c88fefafce5fff5e2d972f5dc362bd5 251 Gene3D G3DSA:3.40.710.10 13 242 1.9E-23 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS13165 6c88fefafce5fff5e2d972f5dc362bd5 251 Pfam PF13354 Beta-lactamase enzyme family 82 207 9.8E-6 T 17-03-2017 SHXM_RS13165 6c88fefafce5fff5e2d972f5dc362bd5 251 SUPERFAMILY SSF56601 14 238 5.2E-25 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS35115 fbef19623d7632bea352d5c06f9ff5d9 415 Gene3D G3DSA:1.25.40.10 144 389 1.5E-9 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34670 d087c6feef7740c423e5ae046f486924 266 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 216 257 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS34670 d087c6feef7740c423e5ae046f486924 266 Pfam PF12833 Helix-turn-helix domain 185 261 4.4E-14 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS34670 d087c6feef7740c423e5ae046f486924 266 SMART SM00342 179 261 3.2E-10 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS29140 f8154bb8e96da2563b1372906bf5aecf 110 SUPERFAMILY SSF54913 2 105 2.63E-29 T 17-03-2017 IPR011322 Nitrogen regulatory PII-like, alpha/beta SHXM_RS29140 f8154bb8e96da2563b1372906bf5aecf 110 Pfam PF03091 CutA1 divalent ion tolerance protein 7 102 8.5E-27 T 17-03-2017 IPR004323 Divalent ion tolerance protein, CutA GO:0010038 SHXM_RS29140 f8154bb8e96da2563b1372906bf5aecf 110 Gene3D G3DSA:3.30.70.830 2 106 2.4E-30 T 17-03-2017 SHXM_RS01785 63d09b3776c34654dc91c415871d3165 388 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 6 383 4.7E-119 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS01785 63d09b3776c34654dc91c415871d3165 388 PIRSF PIRSF001434 1 388 6.9E-124 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS01785 63d09b3776c34654dc91c415871d3165 388 Gene3D G3DSA:3.90.1150.10 253 383 4.4E-38 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS01785 63d09b3776c34654dc91c415871d3165 388 SUPERFAMILY SSF53383 22 383 3.59E-104 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS01785 63d09b3776c34654dc91c415871d3165 388 Gene3D G3DSA:3.40.640.10 5 252 4.9E-88 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS01785 63d09b3776c34654dc91c415871d3165 388 ProSitePatterns PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 196 210 - T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 14 254 4.8E-66 T 17-03-2017 SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 SUPERFAMILY SSF51735 4 255 8.79E-79 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 1.7E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 161 180 1.7E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 1.7E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 Gene3D G3DSA:3.40.50.720 4 255 4.1E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 3.9E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 3.9E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 182 199 3.9E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 3.9E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 3.9E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS10735 a7bfa35b29611876e21313a194ee5c14 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 180 3.9E-45 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41210 e84644a39e8c7b47ba3e4bc52a7710c4 412 Pfam PF12006 Protein of unknown function (DUF3500) 74 394 4.7E-81 T 17-03-2017 IPR021889 Protein of unknown function DUF3500 SHXM_RS47575 5a37b4676b8abbb6168c5e89c4986fc6 174 Pfam PF13419 Haloacid dehalogenase-like hydrolase 40 138 7.4E-12 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS47575 5a37b4676b8abbb6168c5e89c4986fc6 174 SUPERFAMILY SSF56784 34 157 9.36E-28 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS47575 5a37b4676b8abbb6168c5e89c4986fc6 174 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 43 138 2.3E-16 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS47575 5a37b4676b8abbb6168c5e89c4986fc6 174 Gene3D G3DSA:3.40.50.1000 39 158 1.6E-37 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS16250 3b8eb1b7a550a6f4cfdde2a7039de046 304 Gene3D G3DSA:3.40.50.720 6 234 2.2E-30 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16250 3b8eb1b7a550a6f4cfdde2a7039de046 304 SUPERFAMILY SSF51735 6 275 3.38E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16250 3b8eb1b7a550a6f4cfdde2a7039de046 304 Pfam PF13460 NAD(P)H-binding 13 200 3.4E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 SUPERFAMILY SSF52540 238 316 7.53E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 SUPERFAMILY SSF52540 451 531 7.53E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 SUPERFAMILY SSF52540 620 839 7.53E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 Gene3D G3DSA:3.40.50.300 245 312 1.8E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 Gene3D G3DSA:3.40.50.300 506 671 1.8E-32 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 Gene3D G3DSA:3.40.50.300 695 836 2.2E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 Pfam PF13245 Part of AAA domain 253 308 1.5E-12 T 17-03-2017 SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 Pfam PF13538 UvrD-like helicase C-terminal domain 792 834 3.0E-8 T 17-03-2017 IPR027785 UvrD-like helicase C-terminal domain SHXM_RS23710 c4ac051b045681560fe06127df1ef9c7 852 Pfam PF00580 UvrD/REP helicase N-terminal domain 622 669 3.2E-6 T 17-03-2017 IPR014016 UvrD-like Helicase, ATP-binding domain GO:0005524 SHXM_RS45560 58e3c4ce4fde6b583d488f0f4b0a0fb3 531 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 95 427 6.7E-62 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS45560 58e3c4ce4fde6b583d488f0f4b0a0fb3 531 Gene3D G3DSA:3.10.105.10 280 482 9.6E-28 T 17-03-2017 SHXM_RS45560 58e3c4ce4fde6b583d488f0f4b0a0fb3 531 SUPERFAMILY SSF53850 48 515 6.33E-89 T 17-03-2017 SHXM_RS45560 58e3c4ce4fde6b583d488f0f4b0a0fb3 531 Gene3D G3DSA:3.90.76.10 60 215 1.8E-32 T 17-03-2017 SHXM_RS33070 294960244aaca11ad4ab4cb05fc0c8f0 310 Gene3D G3DSA:3.40.50.1820 17 297 3.4E-67 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33070 294960244aaca11ad4ab4cb05fc0c8f0 310 SUPERFAMILY SSF53474 60 300 4.4E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33070 294960244aaca11ad4ab4cb05fc0c8f0 310 Pfam PF07859 alpha/beta hydrolase fold 82 289 2.1E-49 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS30765 caf16e9406c0d0cace86a03a05574a4e 251 Hamap MF_01357 NAD(P)H-quinone oxidoreductase subunit J, chloroplastic [ndhJ]. 82 239 27.855 T 17-03-2017 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30765 caf16e9406c0d0cace86a03a05574a4e 251 TIGRFAM TIGR01961 NuoC_fam: NADH (or F420H2) dehydrogenase, subunit C 108 230 1.1E-42 T 17-03-2017 IPR010218 NADH dehydrogenase, subunit C GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30765 caf16e9406c0d0cace86a03a05574a4e 251 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 159 214 3.0E-24 T 17-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30765 caf16e9406c0d0cace86a03a05574a4e 251 SUPERFAMILY SSF143243 95 247 2.48E-45 T 17-03-2017 SHXM_RS30765 caf16e9406c0d0cace86a03a05574a4e 251 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 110 231 1.3E-39 T 17-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS35700 c30b1b259b1351224ea0acd3d4061384 510 Gene3D G3DSA:3.90.1200.10 297 466 5.5E-4 T 17-03-2017 SHXM_RS35700 c30b1b259b1351224ea0acd3d4061384 510 Pfam PF01636 Phosphotransferase enzyme family 295 460 7.0E-8 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS35700 c30b1b259b1351224ea0acd3d4061384 510 SUPERFAMILY SSF56112 191 490 1.53E-18 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS17575 99d9f3cdc5a96f83d5889c1084046ce8 186 Gene3D G3DSA:3.40.630.30 19 176 1.3E-68 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS17575 99d9f3cdc5a96f83d5889c1084046ce8 186 TIGRFAM TIGR02406 ectoine_EctA: diaminobutyrate acetyltransferase 21 176 3.9E-63 T 17-03-2017 IPR012772 L-2,4-diaminobutyric acid acetyltransferase GO:0019491|GO:0033816 KEGG: 00250+2.3.1.17|KEGG: 00260+2.3.1.178 SHXM_RS17575 99d9f3cdc5a96f83d5889c1084046ce8 186 Pfam PF00583 Acetyltransferase (GNAT) family 68 141 6.0E-9 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS17575 99d9f3cdc5a96f83d5889c1084046ce8 186 SUPERFAMILY SSF55729 15 140 3.66E-19 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Pfam PF00069 Protein kinase domain 18 232 1.1E-47 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 ProSitePatterns PS00108 Serine/Threonine protein kinases active-site signature. 137 149 - T 17-03-2017 IPR008271 Serine/threonine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Gene3D G3DSA:3.30.200.20 11 84 1.5E-23 T 17-03-2017 SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Gene3D G3DSA:1.10.510.10 85 265 6.3E-47 T 17-03-2017 SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SUPERFAMILY SSF56112 10 272 9.58E-71 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SUPERFAMILY SSF54184 579 638 1.1E-7 T 17-03-2017 SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SMART SM00740 442 509 4.2E-13 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SMART SM00740 375 441 4.4E-11 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SMART SM00740 575 639 1.1E-12 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SMART SM00740 510 574 6.5E-15 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Pfam PF03793 PASTA domain 380 441 2.0E-13 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Pfam PF03793 PASTA domain 447 509 1.1E-10 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Pfam PF03793 PASTA domain 513 574 4.3E-14 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 Pfam PF03793 PASTA domain 579 637 4.3E-12 T 17-03-2017 IPR005543 PASTA domain SHXM_RS18710 990ac5e7584c8fde592c654a0b4b0103 642 SMART SM00220 18 277 2.7E-49 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS20845 1bf3f8b21a58a59acdb378d8d1da52d4 210 Pfam PF00775 Dioxygenase 50 134 1.2E-8 T 17-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 SHXM_RS20845 1bf3f8b21a58a59acdb378d8d1da52d4 210 TIGRFAM TIGR02423 protocat_alph: protocatechuate 3,4-dioxygenase, alpha subunit 22 208 2.4E-50 T 17-03-2017 IPR012786 Protocatechuate 3,4-dioxygenase, alpha subunit GO:0005506|GO:0018578|GO:0019439|GO:0055114 KEGG: 00362+1.13.11.3|KEGG: 00624+1.13.11.3 SHXM_RS20845 1bf3f8b21a58a59acdb378d8d1da52d4 210 Gene3D G3DSA:2.60.130.10 18 208 2.3E-58 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS20845 1bf3f8b21a58a59acdb378d8d1da52d4 210 SUPERFAMILY SSF49482 18 208 3.14E-43 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS19165 91da2383727b40903c308c96be188896 269 Gene3D G3DSA:3.60.110.10 2 265 3.7E-65 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS19165 91da2383727b40903c308c96be188896 269 SUPERFAMILY SSF56317 3 263 1.44E-61 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS19165 91da2383727b40903c308c96be188896 269 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 140 160 - T 17-03-2017 IPR001110 Uncharacterised protein family UPF0012, conserved site SHXM_RS19165 91da2383727b40903c308c96be188896 269 Pfam PF00795 Carbon-nitrogen hydrolase 4 255 6.1E-35 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS09420 3b04a4abf89a27e1000c21a8d2330d48 352 Pfam PF01548 Transposase 4 154 1.5E-18 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS47905 41478b6cef1a5cae96120ec2b8fab8ec 238 Pfam PF00378 Enoyl-CoA hydratase/isomerase 10 225 4.7E-49 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS47905 41478b6cef1a5cae96120ec2b8fab8ec 238 Gene3D G3DSA:3.90.226.10 2 236 7.1E-65 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47905 41478b6cef1a5cae96120ec2b8fab8ec 238 SUPERFAMILY SSF52096 2 232 8.2E-65 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47905 41478b6cef1a5cae96120ec2b8fab8ec 238 ProSitePatterns PS00166 Enoyl-CoA hydratase/isomerase signature. 99 119 - T 17-03-2017 IPR018376 Enoyl-CoA hydratase/isomerase, conserved site GO:0003824|GO:0008152 SHXM_RS33965 be40bd5531076546c4ac12a5b9fed283 334 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 137 333 2.0E-30 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33965 be40bd5531076546c4ac12a5b9fed283 334 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 29 70 7.7E-10 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS33965 be40bd5531076546c4ac12a5b9fed283 334 SUPERFAMILY SSF161098 114 318 4.32E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33965 be40bd5531076546c4ac12a5b9fed283 334 Gene3D G3DSA:1.10.3720.10 110 330 1.9E-29 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45525 e67c072099efe87626199c2881344619 231 Gene3D G3DSA:3.40.50.880 4 217 7.6E-62 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS45525 e67c072099efe87626199c2881344619 231 Pfam PF01965 DJ-1/PfpI family 118 197 1.7E-12 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS45525 e67c072099efe87626199c2881344619 231 SUPERFAMILY SSF52317 106 216 2.23E-29 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS45525 e67c072099efe87626199c2881344619 231 SUPERFAMILY SSF52317 4 77 2.23E-29 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS00385 7678d75b96607a5fc04137a46545272b 297 SUPERFAMILY SSF55785 176 280 3.49E-19 T 17-03-2017 IPR000014 PAS domain SHXM_RS00385 7678d75b96607a5fc04137a46545272b 297 Pfam PF08447 PAS fold 193 275 1.1E-20 T 17-03-2017 IPR013655 PAS fold-3 GO:0005515 SHXM_RS00385 7678d75b96607a5fc04137a46545272b 297 Gene3D G3DSA:3.30.450.20 165 279 3.7E-22 T 17-03-2017 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 Gene3D G3DSA:2.102.10.10 44 153 2.7E-29 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 Pfam PF11723 Homotrimeric ring hydroxylase 290 385 1.0E-5 T 17-03-2017 IPR021028 Homotrimeric ring hydroxylase, catalytic domain KEGG: 00621+1.14.12.22|MetaCyc: PWY-6550 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 Pfam PF11723 Homotrimeric ring hydroxylase 155 210 2.2E-6 T 17-03-2017 IPR021028 Homotrimeric ring hydroxylase, catalytic domain KEGG: 00621+1.14.12.22|MetaCyc: PWY-6550 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 SUPERFAMILY SSF55961 282 386 5.42E-16 T 17-03-2017 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 SUPERFAMILY SSF55961 167 250 5.42E-16 T 17-03-2017 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 Pfam PF00355 Rieske [2Fe-2S] domain 45 120 2.1E-18 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS45805 d2b741cce91600f5e77f93aea0ad8a2e 405 SUPERFAMILY SSF50022 39 152 5.89E-35 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS00220 d9b9fd6b43d05f442a943099c39635ea 374 Gene3D G3DSA:1.10.150.130 40 109 5.5E-4 T 17-03-2017 IPR023109 Integrase/recombinase, N-terminal SHXM_RS00220 d9b9fd6b43d05f442a943099c39635ea 374 Pfam PF00589 Phage integrase family 166 345 5.2E-16 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS00220 d9b9fd6b43d05f442a943099c39635ea 374 Gene3D G3DSA:1.10.443.10 151 350 1.9E-28 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS00220 d9b9fd6b43d05f442a943099c39635ea 374 SUPERFAMILY SSF56349 35 349 2.33E-26 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS36765 c51e3f90a39542cbf7d7277d63919d3c 140 Pfam PF13828 Domain of unknown function (DUF4190) 59 127 3.1E-10 T 17-03-2017 IPR025241 Domain of unknown function DUF4190 SHXM_RS41805 e09808dceb29fbf3cd09d37ca4cbe8e4 463 SUPERFAMILY SSF75304 3 452 4.32E-145 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS41805 e09808dceb29fbf3cd09d37ca4cbe8e4 463 Pfam PF01425 Amidase 24 444 9.6E-128 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS41805 e09808dceb29fbf3cd09d37ca4cbe8e4 463 Gene3D G3DSA:3.90.1300.10 4 456 8.6E-153 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS41805 e09808dceb29fbf3cd09d37ca4cbe8e4 463 ProSitePatterns PS00571 Amidases signature. 147 178 - T 17-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 SHXM_RS34360 2e3d6c437f38bd56a4504d2eba44085b 369 Gene3D G3DSA:3.40.50.720 16 233 2.2E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34360 2e3d6c437f38bd56a4504d2eba44085b 369 Pfam PF01370 NAD dependent epimerase/dehydratase family 25 233 8.3E-16 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS34360 2e3d6c437f38bd56a4504d2eba44085b 369 SUPERFAMILY SSF51735 22 324 9.41E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38265 fa4540a8db114913b1a85cf31224c52c 483 Pfam PF07690 Major Facilitator Superfamily 35 311 9.7E-22 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS38265 fa4540a8db114913b1a85cf31224c52c 483 SUPERFAMILY SSF103473 272 480 8.76E-60 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS38265 fa4540a8db114913b1a85cf31224c52c 483 SUPERFAMILY SSF103473 22 219 8.76E-60 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS38265 fa4540a8db114913b1a85cf31224c52c 483 Gene3D G3DSA:1.20.1250.20 287 481 3.1E-29 T 17-03-2017 SHXM_RS38265 fa4540a8db114913b1a85cf31224c52c 483 Gene3D G3DSA:1.20.1250.20 27 217 6.2E-28 T 17-03-2017 SHXM_RS38210 f28cb09603103068f1ce6d90a68a5087 497 Pfam PF13520 Amino acid permease 24 453 5.1E-53 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS38210 f28cb09603103068f1ce6d90a68a5087 497 PIRSF PIRSF006060 2 491 2.4E-91 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS43985 705d525cb4edd77026bccda0c7bfcc2b 500 SUPERFAMILY SSF55931 38 464 5.1E-48 T 17-03-2017 SHXM_RS43985 705d525cb4edd77026bccda0c7bfcc2b 500 PIRSF PIRSF012666 1 498 1.0E-206 T 17-03-2017 IPR016602 Uncharacterised conserved protein UCP012666 SHXM_RS49630 67d5b67c8306c2aa5837bdae7d590325 262 Gene3D G3DSA:2.40.400.10 13 244 2.9E-83 T 17-03-2017 IPR023375 Acetoacetate decarboxylase beta barrel domain KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 SHXM_RS49630 67d5b67c8306c2aa5837bdae7d590325 262 Hamap MF_00597 Probable acetoacetate decarboxylase [adc]. 6 244 58.482 T 17-03-2017 IPR023653 Acetoacetate decarboxylase, bacterial GO:0016831 KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 SHXM_RS49630 67d5b67c8306c2aa5837bdae7d590325 262 SUPERFAMILY SSF160104 8 243 1.7E-77 T 17-03-2017 SHXM_RS49630 67d5b67c8306c2aa5837bdae7d590325 262 Pfam PF06314 Acetoacetate decarboxylase (ADC) 15 243 5.3E-71 T 17-03-2017 IPR010451 Acetoacetate decarboxylase GO:0016829 KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 SHXM_RS35385 455f6e803c84035bf9e168e2f155aab5 184 Pfam PF03413 Peptidase propeptide and YPEB domain 125 174 4.0E-4 T 17-03-2017 IPR025711 PepSY domain SHXM_RS35810 b246d1edcd51df60d4390dddd94a7b63 245 SUPERFAMILY SSF52317 1 200 1.27E-39 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS35810 b246d1edcd51df60d4390dddd94a7b63 245 Gene3D G3DSA:3.40.50.880 1 227 3.4E-73 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS35810 b246d1edcd51df60d4390dddd94a7b63 245 Pfam PF03575 Peptidase family S51 3 202 3.0E-56 T 17-03-2017 IPR005320 Peptidase S51 GO:0006508|GO:0008236 SHXM_RS26165 666a63dc2a322da6b8b0984ad288578c 243 SUPERFAMILY SSF53335 11 135 2.98E-10 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26165 666a63dc2a322da6b8b0984ad288578c 243 Gene3D G3DSA:3.40.50.150 44 132 1.6E-6 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24625 9e2c9f0411ef4f1e8ee47180e49dcc15 487 Pfam PF09852 Predicted membrane protein (DUF2079) 61 482 6.9E-59 T 17-03-2017 IPR018650 Sulfolobus virus STSV1, Orf64 SHXM_RS39955 1beef74d638d440f235153e993bba0e9 416 SUPERFAMILY SSF103473 10 390 2.62E-40 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS39955 1beef74d638d440f235153e993bba0e9 416 Pfam PF07690 Major Facilitator Superfamily 19 272 3.5E-21 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS39955 1beef74d638d440f235153e993bba0e9 416 ProSitePatterns PS00216 Sugar transport proteins signature 1. 68 84 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS39955 1beef74d638d440f235153e993bba0e9 416 Gene3D G3DSA:1.20.1250.20 215 388 2.0E-4 T 17-03-2017 SHXM_RS39955 1beef74d638d440f235153e993bba0e9 416 Gene3D G3DSA:1.20.1250.20 16 193 1.8E-25 T 17-03-2017 SHXM_RS23345 5106cbb46b64b56157984a55ff1dfc02 266 Pfam PF06182 ABC-2 family transporter protein 40 260 1.0E-14 T 17-03-2017 IPR010390 Protein of unknown function DUF990 SHXM_RS49735 473d122d984041723698c9c8d0a2c46e 267 Pfam PF00005 ABC transporter 24 164 4.8E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49735 473d122d984041723698c9c8d0a2c46e 267 SUPERFAMILY SSF52540 7 227 8.31E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49735 473d122d984041723698c9c8d0a2c46e 267 Gene3D G3DSA:3.40.50.300 6 230 7.0E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49735 473d122d984041723698c9c8d0a2c46e 267 ProSitePatterns PS00211 ABC transporters family signature. 137 151 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS49735 473d122d984041723698c9c8d0a2c46e 267 SMART SM00382 33 239 4.4E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS15645 560636bb872646303cbc83ec657bec67 403 SUPERFAMILY SSF52540 70 184 6.93E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02520 1c7a66cdb93be0aa0d77d1f56620c532 73 SUPERFAMILY SSF51338 6 71 1.58E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS02520 1c7a66cdb93be0aa0d77d1f56620c532 73 Gene3D G3DSA:2.30.40.10 2 72 5.2E-11 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS42010 6aa4d2a81e197b53e79c5888b31fab2e 205 Gene3D G3DSA:1.10.3300.10 29 204 7.9E-38 T 17-03-2017 IPR023286 ABATE domain SHXM_RS42010 6aa4d2a81e197b53e79c5888b31fab2e 205 SUPERFAMILY SSF160904 26 202 1.57E-34 T 17-03-2017 SHXM_RS42010 6aa4d2a81e197b53e79c5888b31fab2e 205 Pfam PF07336 Putative stress-induced transcription regulator 33 152 2.5E-13 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS42010 6aa4d2a81e197b53e79c5888b31fab2e 205 Pfam PF11706 CGNR zinc finger 160 203 1.2E-18 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS41125 6d377a43587754c40a0295c0453e28c8 418 Gene3D G3DSA:3.40.710.10 97 400 9.4E-52 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS41125 6d377a43587754c40a0295c0453e28c8 418 SUPERFAMILY SSF56601 40 408 3.99E-91 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS41125 6d377a43587754c40a0295c0453e28c8 418 Pfam PF00144 Beta-lactamase 96 407 9.4E-48 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS27010 8e1ffdf26541f9901f311672de7442c0 277 SUPERFAMILY SSF55811 147 216 2.46E-12 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27010 8e1ffdf26541f9901f311672de7442c0 277 SUPERFAMILY SSF55811 26 61 2.46E-12 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27010 8e1ffdf26541f9901f311672de7442c0 277 SUPERFAMILY SSF55811 91 102 2.46E-12 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27010 8e1ffdf26541f9901f311672de7442c0 277 Gene3D G3DSA:3.90.79.10 26 102 5.8E-14 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27010 8e1ffdf26541f9901f311672de7442c0 277 Gene3D G3DSA:3.90.79.10 140 203 5.8E-14 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS10060 904aed215535f6508e96b0201ee35cb6 239 Pfam PF03771 Domain of unknown function (DUF317) 53 115 2.6E-7 T 17-03-2017 IPR005523 Domain of unknown function DUF317 SHXM_RS10060 904aed215535f6508e96b0201ee35cb6 239 Pfam PF03771 Domain of unknown function (DUF317) 170 220 9.0E-8 T 17-03-2017 IPR005523 Domain of unknown function DUF317 SHXM_RS50615 2052788cba696ec2ccf6d71077c3397c 588 Pfam PF16995 Transmembrane region of lysyl-tRNA synthetase 31 227 1.3E-13 T 17-03-2017 IPR031553 Lysyl-tRNA synthetase, N-terminal transmembrane region KEGG: 00970+6.1.1.6 SHXM_RS50615 2052788cba696ec2ccf6d71077c3397c 588 SUPERFAMILY SSF55729 367 492 5.77E-6 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS50615 2052788cba696ec2ccf6d71077c3397c 588 Pfam PF09924 Uncharacterised conserved protein (DUF2156) 251 550 1.5E-110 T 17-03-2017 IPR024320 Phosphatidylglycerol lysyltransferase, C-terminal SHXM_RS50615 2052788cba696ec2ccf6d71077c3397c 588 SUPERFAMILY SSF103473 210 242 2.09E-5 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS50615 2052788cba696ec2ccf6d71077c3397c 588 SUPERFAMILY SSF103473 27 171 2.09E-5 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS01610 50b97ecf6d650533d12b645d84ccf797 355 Gene3D G3DSA:3.20.20.30 14 266 4.7E-43 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01610 50b97ecf6d650533d12b645d84ccf797 355 Gene3D G3DSA:3.20.20.30 303 355 4.7E-43 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01610 50b97ecf6d650533d12b645d84ccf797 355 Pfam PF00296 Luciferase-like monooxygenase 13 334 8.4E-29 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01610 50b97ecf6d650533d12b645d84ccf797 355 SUPERFAMILY SSF51679 13 348 5.77E-36 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS14475 dbe8b75566cd554dfa1c03188d02672c 211 Gene3D G3DSA:2.60.40.10 2 87 1.5E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS14475 dbe8b75566cd554dfa1c03188d02672c 211 Gene3D G3DSA:2.60.40.10 119 202 6.5E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS14475 dbe8b75566cd554dfa1c03188d02672c 211 SUPERFAMILY SSF49265 2 80 2.55E-5 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS14475 dbe8b75566cd554dfa1c03188d02672c 211 SUPERFAMILY SSF49265 112 205 3.36E-6 T 17-03-2017 IPR003961 Fibronectin type III GO:0005515 SHXM_RS33930 63d7f14ce5c4992ffe54e1c348697e79 133 Pfam PF01850 PIN domain 36 112 5.0E-5 T 17-03-2017 IPR002716 PIN domain SHXM_RS33930 63d7f14ce5c4992ffe54e1c348697e79 133 SUPERFAMILY SSF88723 10 116 2.35E-7 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS05165 82bd9711d252e1dfa0a2d83cc208947b 157 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 11 151 7.9E-19 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS05165 82bd9711d252e1dfa0a2d83cc208947b 157 Gene3D G3DSA:3.30.530.20 5 152 4.7E-30 T 17-03-2017 IPR023393 START-like domain SHXM_RS05165 82bd9711d252e1dfa0a2d83cc208947b 157 SUPERFAMILY SSF55961 4 152 3.87E-32 T 17-03-2017 SHXM_RS47390 3190de83a0c819f6e90754ffde5ea183 213 Pfam PF02525 Flavodoxin-like fold 4 161 2.6E-25 T 17-03-2017 IPR003680 Flavodoxin-like fold SHXM_RS47390 3190de83a0c819f6e90754ffde5ea183 213 SUPERFAMILY SSF52218 3 167 4.92E-31 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS47390 3190de83a0c819f6e90754ffde5ea183 213 Gene3D G3DSA:3.40.50.360 1 175 2.1E-41 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS47390 3190de83a0c819f6e90754ffde5ea183 213 Hamap MF_01216 FMN-dependent NADH-azoreductase [azoR]. 2 208 22.445 T 17-03-2017 IPR023048 NADH-azoreductase, FMN-dependent GO:0016661|GO:0055114 SHXM_RS33040 8d4712219d07333f96186d4055647afa 156 Pfam PF03259 Roadblock/LC7 domain 26 116 6.8E-17 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS33040 8d4712219d07333f96186d4055647afa 156 Gene3D G3DSA:3.30.450.30 22 140 2.7E-20 T 17-03-2017 SHXM_RS33040 8d4712219d07333f96186d4055647afa 156 SMART SM00960 26 116 5.8E-22 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS33040 8d4712219d07333f96186d4055647afa 156 SUPERFAMILY SSF103196 22 141 3.66E-25 T 17-03-2017 SHXM_RS33775 764a70c873cff0ff09f2b25890e98a22 418 SMART SM00530 2 57 2.8E-12 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS33775 764a70c873cff0ff09f2b25890e98a22 418 Gene3D G3DSA:1.25.40.10 179 381 3.0E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS33775 764a70c873cff0ff09f2b25890e98a22 418 Gene3D G3DSA:1.10.260.40 3 57 9.0E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33775 764a70c873cff0ff09f2b25890e98a22 418 SUPERFAMILY SSF47413 3 58 8.32E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33775 764a70c873cff0ff09f2b25890e98a22 418 Pfam PF01381 Helix-turn-helix 3 57 9.0E-13 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS33775 764a70c873cff0ff09f2b25890e98a22 418 SUPERFAMILY SSF48452 176 334 1.56E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS12285 8dcee282866d3e532432f089fc53c611 314 SUPERFAMILY SSF56601 58 288 9.05E-30 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS12285 8dcee282866d3e532432f089fc53c611 314 Pfam PF13354 Beta-lactamase enzyme family 119 260 2.3E-10 T 17-03-2017 SHXM_RS12285 8dcee282866d3e532432f089fc53c611 314 Gene3D G3DSA:3.40.710.10 58 286 2.4E-28 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 SUPERFAMILY SSF56801 42 559 5.89E-99 T 17-03-2017 SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 Gene3D G3DSA:3.40.50.980 47 222 1.9E-30 T 17-03-2017 SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 Gene3D G3DSA:3.40.50.980 223 374 7.4E-31 T 17-03-2017 SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 Pfam PF00501 AMP-binding enzyme 48 462 3.1E-65 T 17-03-2017 IPR000873 AMP-dependent synthetase/ligase GO:0003824|GO:0008152 SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 Gene3D G3DSA:3.30.300.30 465 559 4.2E-15 T 17-03-2017 SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 Pfam PF13193 AMP-binding enzyme C-terminal domain 473 547 1.2E-8 T 17-03-2017 IPR025110 AMP-binding enzyme C-terminal domain SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 ProSitePatterns PS00455 Putative AMP-binding domain signature. 217 228 - T 17-03-2017 IPR020845 AMP-binding, conserved site SHXM_RS39665 951102386bba8034d5892c7bf1fd9e7d 565 Gene3D G3DSA:2.30.38.10 384 457 7.6E-5 T 17-03-2017 SHXM_RS27115 0ea414644d17cee8946574054d1aefd4 310 Pfam PF02104 SURF1 family 19 255 8.6E-19 T 17-03-2017 IPR002994 Surfeit locus 1/Shy1 GO:0016020 Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS21080 a82e3c37eb7bae333417ec1ae09f313a 192 Gene3D G3DSA:1.10.357.10 7 190 1.8E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS21080 a82e3c37eb7bae333417ec1ae09f313a 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 56 2.1E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS21080 a82e3c37eb7bae333417ec1ae09f313a 192 SUPERFAMILY SSF46689 3 67 7.18E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47025 9283ae918cf50fb4252a9745eecffd4e 405 SUPERFAMILY SSF51445 67 291 3.15E-16 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS47025 9283ae918cf50fb4252a9745eecffd4e 405 Gene3D G3DSA:3.20.20.80 302 329 6.8E-5 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS47025 9283ae918cf50fb4252a9745eecffd4e 405 Gene3D G3DSA:3.20.20.80 229 268 6.8E-5 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS09985 5b81a1239ef7285cd37551c06a37cc12 25 SUPERFAMILY SSF143422 3 24 4.19E-6 T 17-03-2017 IPR002686 Transposase IS200-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS09985 5b81a1239ef7285cd37551c06a37cc12 25 Gene3D G3DSA:3.30.70.1290 3 25 6.7E-6 T 17-03-2017 IPR002686 Transposase IS200-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS09985 5b81a1239ef7285cd37551c06a37cc12 25 Pfam PF01797 Transposase IS200 like 2 24 2.4E-5 T 17-03-2017 IPR002686 Transposase IS200-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS49170 a0a3fd51f6566fc5265a84f3b0382719 301 SUPERFAMILY SSF161098 31 297 3.4E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49170 a0a3fd51f6566fc5265a84f3b0382719 301 Gene3D G3DSA:1.10.3720.10 27 287 2.1E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49170 a0a3fd51f6566fc5265a84f3b0382719 301 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 289 8.2E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43795 74725e238d5d11a07654549812c6a50f 142 Pfam PF03259 Roadblock/LC7 domain 19 110 5.8E-24 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS43795 74725e238d5d11a07654549812c6a50f 142 Gene3D G3DSA:3.30.450.30 18 137 1.0E-24 T 17-03-2017 SHXM_RS43795 74725e238d5d11a07654549812c6a50f 142 SUPERFAMILY SSF103196 15 139 1.92E-34 T 17-03-2017 SHXM_RS43795 74725e238d5d11a07654549812c6a50f 142 SMART SM00960 20 110 1.2E-26 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS08175 ecfc96a55cbc2fbb27fb32605427abb2 325 Pfam PF03640 Secreted repeat of unknown function 151 192 8.0E-17 T 17-03-2017 IPR005297 Lipoprotein repeat SHXM_RS08175 ecfc96a55cbc2fbb27fb32605427abb2 325 Pfam PF03640 Secreted repeat of unknown function 275 316 6.3E-14 T 17-03-2017 IPR005297 Lipoprotein repeat SHXM_RS08175 ecfc96a55cbc2fbb27fb32605427abb2 325 Pfam PF03640 Secreted repeat of unknown function 93 133 3.5E-14 T 17-03-2017 IPR005297 Lipoprotein repeat SHXM_RS08175 ecfc96a55cbc2fbb27fb32605427abb2 325 Pfam PF03640 Secreted repeat of unknown function 217 258 1.9E-13 T 17-03-2017 IPR005297 Lipoprotein repeat SHXM_RS08295 1b683ccd694afaebe84f0ac99d94d5df 334 TIGRFAM TIGR02778 ligD_pol: DNA ligase D, polymerase domain 14 258 2.2E-74 T 17-03-2017 IPR014145 DNA ligase D, polymerase domain SHXM_RS08295 1b683ccd694afaebe84f0ac99d94d5df 334 Pfam PF01896 DNA primase small subunit 135 255 5.0E-8 T 17-03-2017 IPR002755 DNA primase, small subunit GO:0003896|GO:0006269 Reactome: R-HSA-113501|Reactome: R-HSA-174411|Reactome: R-HSA-174430|Reactome: R-HSA-68952|Reactome: R-HSA-68962|Reactome: R-HSA-69091|Reactome: R-HSA-69109|Reactome: R-HSA-69166|Reactome: R-HSA-69183 SHXM_RS00240 19c5465e75d3f50b3b4abaa82c930269 393 SUPERFAMILY SSF47413 203 267 3.56E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00240 19c5465e75d3f50b3b4abaa82c930269 393 Pfam PF13560 Helix-turn-helix domain 205 258 2.2E-7 T 17-03-2017 SHXM_RS00240 19c5465e75d3f50b3b4abaa82c930269 393 Gene3D G3DSA:1.10.260.40 203 263 4.6E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS41680 3d0206f6bb2effa2c82aced1a52bfa62 196 Pfam PF00652 Ricin-type beta-trefoil lectin domain 71 192 6.4E-33 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41680 3d0206f6bb2effa2c82aced1a52bfa62 196 SUPERFAMILY SSF50370 71 194 4.33E-43 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41680 3d0206f6bb2effa2c82aced1a52bfa62 196 Gene3D G3DSA:2.80.10.50 69 194 1.4E-45 T 17-03-2017 SHXM_RS41680 3d0206f6bb2effa2c82aced1a52bfa62 196 SMART SM00458 71 195 3.6E-35 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 SUPERFAMILY SSF46946 121 205 1.47E-24 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 ProSitePatterns PS01242 Zinc finger FPG-type signature. 243 267 - T 17-03-2017 IPR015887 DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site GO:0003677|GO:0003906|GO:0006281|GO:0008270|GO:0016799 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 SMART SM01232 122 214 6.2E-35 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 SMART SM00898 2 108 2.4E-18 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 SUPERFAMILY SSF57716 220 267 2.52E-13 T 17-03-2017 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 Gene3D G3DSA:1.10.8.50 123 268 4.3E-45 T 17-03-2017 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 Pfam PF01149 Formamidopyrimidine-DNA glycosylase N-terminal domain 1 94 2.6E-7 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 SUPERFAMILY SSF81624 2 123 6.67E-22 T 17-03-2017 IPR012319 Formamidopyrimidine-DNA glycosylase, catalytic domain GO:0003684|GO:0003906|GO:0006284|GO:0008270|GO:0016799 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 Gene3D G3DSA:3.20.190.10 2 122 3.5E-14 T 17-03-2017 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 Pfam PF06827 Zinc finger found in FPG and IleRS 240 267 6.8E-7 T 17-03-2017 IPR010663 Zinc finger, FPG/IleRS-type Reactome: R-HSA-379726 SHXM_RS21755 3d80d76739660eaa61b1aeede752002c 269 Pfam PF06831 Formamidopyrimidine-DNA glycosylase H2TH domain 122 205 1.7E-20 T 17-03-2017 IPR015886 DNA glycosylase/AP lyase, H2TH DNA-binding GO:0003684|GO:0003906|GO:0006289|GO:0008270|GO:0016799 SHXM_RS38555 bc1e2639cf99a6f2a29a0c44ebe37027 240 Pfam PF00929 Exonuclease 10 178 9.3E-19 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS38555 bc1e2639cf99a6f2a29a0c44ebe37027 240 SMART SM00479 7 188 9.1E-18 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS38555 bc1e2639cf99a6f2a29a0c44ebe37027 240 SUPERFAMILY SSF53098 6 202 5.06E-47 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS38555 bc1e2639cf99a6f2a29a0c44ebe37027 240 Gene3D G3DSA:3.30.420.10 7 188 4.3E-41 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50310 150052dd21f439804d06b73fcf0a1410 376 Gene3D G3DSA:3.90.1150.10 264 372 6.3E-23 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS50310 150052dd21f439804d06b73fcf0a1410 376 ProSitePatterns PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 224 237 - T 17-03-2017 IPR004838 Aminotransferases, class-I, pyridoxal-phosphate-binding site GO:0003824|GO:0009058|GO:0030170 SHXM_RS50310 150052dd21f439804d06b73fcf0a1410 376 Pfam PF00155 Aminotransferase class I and II 23 360 1.1E-64 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS50310 150052dd21f439804d06b73fcf0a1410 376 Gene3D G3DSA:3.40.640.10 35 263 7.6E-74 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS50310 150052dd21f439804d06b73fcf0a1410 376 SUPERFAMILY SSF53383 4 372 2.5E-103 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS24780 338ab8b28a386571ea21009c4e22a6ec 213 SUPERFAMILY SSF52540 6 151 1.05E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24780 338ab8b28a386571ea21009c4e22a6ec 213 PRINTS PR00988 Uridine kinase signature 8 25 3.0E-7 T 17-03-2017 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193 SHXM_RS24780 338ab8b28a386571ea21009c4e22a6ec 213 PRINTS PR00988 Uridine kinase signature 79 94 3.0E-7 T 17-03-2017 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193 SHXM_RS24780 338ab8b28a386571ea21009c4e22a6ec 213 PRINTS PR00988 Uridine kinase signature 139 149 3.0E-7 T 17-03-2017 IPR000764 Uridine kinase-like KEGG: 00240+2.7.1.48|KEGG: 00983+2.7.1.48|MetaCyc: PWY-7193 SHXM_RS24780 338ab8b28a386571ea21009c4e22a6ec 213 Gene3D G3DSA:3.40.50.300 10 157 1.1E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35865 832eb1ca7e5466da17c15faad8e30f7b 177 Gene3D G3DSA:3.30.565.10 86 161 1.7E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35865 832eb1ca7e5466da17c15faad8e30f7b 177 SUPERFAMILY SSF55874 73 163 1.42E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35865 832eb1ca7e5466da17c15faad8e30f7b 177 Pfam PF13581 Histidine kinase-like ATPase domain 57 156 1.4E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS47205 85ad6a2c269eb713e55372baf3afdd06 127 Gene3D G3DSA:2.60.40.10 1 58 5.6E-7 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS47205 85ad6a2c269eb713e55372baf3afdd06 127 SUPERFAMILY SSF81296 1 56 2.04E-5 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS36750 bae541fdd56b178a339eaff8dbb57837 229 Gene3D G3DSA:3.20.20.190 7 226 2.6E-46 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS36750 bae541fdd56b178a339eaff8dbb57837 229 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 163 220 2.7E-8 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS36750 bae541fdd56b178a339eaff8dbb57837 229 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 13 82 1.0E-20 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS36750 bae541fdd56b178a339eaff8dbb57837 229 SUPERFAMILY SSF51695 10 225 8.89E-49 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 SUPERFAMILY SSF53474 7 188 5.02E-64 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 SUPERFAMILY SSF53474 217 324 5.02E-64 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 PRINTS PR00412 Epoxide hydrolase signature 102 115 8.6E-29 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 PRINTS PR00412 Epoxide hydrolase signature 56 71 8.6E-29 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 PRINTS PR00412 Epoxide hydrolase signature 299 321 8.6E-29 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 PRINTS PR00412 Epoxide hydrolase signature 36 54 8.6E-29 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 PRINTS PR00412 Epoxide hydrolase signature 116 129 8.6E-29 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 Pfam PF00561 alpha/beta hydrolase fold 30 133 8.0E-24 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS32055 7ea8bbe2d4cb5e7e04ac61ea9891fd14 328 Gene3D G3DSA:3.40.50.1820 7 325 2.2E-79 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 Gene3D G3DSA:3.90.180.10 1 143 3.9E-36 T 17-03-2017 IPR011032 GroES-like SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 91 1.4E-8 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 SMART SM00829 10 295 9.1E-13 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 Pfam PF13602 Zinc-binding dehydrogenase 187 295 6.4E-12 T 17-03-2017 SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 SUPERFAMILY SSF51735 111 234 7.79E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 Gene3D G3DSA:3.40.50.720 144 230 5.0E-15 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 ProSitePatterns PS01162 Quinone oxidoreductase / zeta-crystallin signature. 138 159 - T 17-03-2017 IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site GO:0008270|GO:0016491 SHXM_RS47265 92dcceebe606c7709d2c96f5763c8a9f 297 SUPERFAMILY SSF50129 1 147 8.83E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS26895 901ee023ea3cb6715451bde8e43089e0 113 Pfam PF01740 STAS domain 8 108 4.5E-18 T 17-03-2017 IPR002645 STAS domain SHXM_RS26895 901ee023ea3cb6715451bde8e43089e0 113 Gene3D G3DSA:3.30.750.24 3 111 1.8E-40 T 17-03-2017 IPR002645 STAS domain SHXM_RS26895 901ee023ea3cb6715451bde8e43089e0 113 SUPERFAMILY SSF52091 3 110 1.96E-31 T 17-03-2017 IPR002645 STAS domain SHXM_RS26895 901ee023ea3cb6715451bde8e43089e0 113 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 3 106 3.9E-33 T 17-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 44 67 2.4E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 23 36 2.4E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 Gene3D G3DSA:1.10.10.60 12 69 1.3E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 SUPERFAMILY SSF48498 91 191 5.07E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 Pfam PF00440 Bacterial regulatory proteins, tetR family 23 67 3.7E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 SUPERFAMILY SSF46689 10 81 7.18E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47175 515f44719d4c5adff9def7de126243cc 224 Gene3D G3DSA:1.10.357.10 88 192 3.5E-9 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS02530 fb5617b78768e65478109c0dc04844bb 121 SUPERFAMILY SSF51182 25 116 8.66E-8 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS02530 fb5617b78768e65478109c0dc04844bb 121 Gene3D G3DSA:2.60.120.10 39 110 4.5E-7 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 Pfam PF01494 FAD binding domain 18 358 8.3E-64 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 170 185 1.3E-33 T 17-03-2017 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 326 344 1.3E-33 T 17-03-2017 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 20 42 1.3E-33 T 17-03-2017 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 308 324 1.3E-33 T 17-03-2017 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 344 360 1.3E-33 T 17-03-2017 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 293 308 1.3E-33 T 17-03-2017 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 Gene3D G3DSA:3.50.50.60 281 364 4.1E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 Gene3D G3DSA:3.50.50.60 20 196 4.1E-45 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 SUPERFAMILY SSF51905 280 384 4.32E-59 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42850 5ad71aa7ab70825773caf2aabd8ea0d7 545 SUPERFAMILY SSF51905 20 191 4.32E-59 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS02090 20b844472f511fcc63e283d0b51d0f4b 351 Pfam PF00144 Beta-lactamase 23 333 7.6E-55 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS02090 20b844472f511fcc63e283d0b51d0f4b 351 SUPERFAMILY SSF56601 17 339 2.99E-65 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS02090 20b844472f511fcc63e283d0b51d0f4b 351 Gene3D G3DSA:3.40.710.10 15 337 1.7E-65 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS24505 b9d4fcae0a341f1df9f902373a76ba2b 292 Pfam PF12811 Bax inhibitor 1 like 38 291 1.6E-81 T 17-03-2017 IPR010539 Protein of unknown function UCP009160 SHXM_RS24505 b9d4fcae0a341f1df9f902373a76ba2b 292 PIRSF PIRSF009160 1 292 3.0E-90 T 17-03-2017 IPR010539 Protein of unknown function UCP009160 SHXM_RS32630 e30cb560ebcbdf2cf78718eeb7f7e214 255 Gene3D G3DSA:3.40.50.1820 2 251 5.7E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32630 e30cb560ebcbdf2cf78718eeb7f7e214 255 SUPERFAMILY SSF53474 2 251 3.77E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32630 e30cb560ebcbdf2cf78718eeb7f7e214 255 Pfam PF12697 Alpha/beta hydrolase family 4 240 8.5E-13 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS03375 07dcc06251160835016f4d5a27670e30 316 Pfam PF13581 Histidine kinase-like ATPase domain 204 313 4.4E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS03375 07dcc06251160835016f4d5a27670e30 316 Pfam PF14417 MEDS: MEthanogen/methylotroph, DcmR Sensory domain 17 159 3.5E-25 T 17-03-2017 IPR025847 MEDS domain SHXM_RS07130 98dc7d847f6fedbe9fa43fe6771f3923 355 SUPERFAMILY SSF51695 40 231 6.28E-13 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS07130 98dc7d847f6fedbe9fa43fe6771f3923 355 Pfam PF16670 Phosphoinositide phospholipase C, Ca2+-dependent 113 208 6.6E-12 T 17-03-2017 IPR032075 Phosphoinositide phospholipase C, Ca2+-dependent SHXM_RS29905 f809eb535699a429aa1c6d74647705ec 237 Pfam PF01569 PAP2 superfamily 76 179 1.9E-15 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS29905 f809eb535699a429aa1c6d74647705ec 237 Gene3D G3DSA:1.20.144.10 12 178 5.0E-27 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS29905 f809eb535699a429aa1c6d74647705ec 237 SUPERFAMILY SSF48317 11 182 2.75E-32 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS29905 f809eb535699a429aa1c6d74647705ec 237 SMART SM00014 68 179 6.7E-10 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS24935 60edb712eeac08a9de293949ba02a1a2 326 Gene3D G3DSA:3.20.20.70 27 293 2.1E-99 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS24935 60edb712eeac08a9de293949ba02a1a2 326 SUPERFAMILY SSF51569 27 306 4.76E-85 T 17-03-2017 SHXM_RS24935 60edb712eeac08a9de293949ba02a1a2 326 Pfam PF03102 NeuB family 57 293 7.7E-81 T 17-03-2017 IPR013132 N-acetylneuraminic acid synthase, N-terminal GO:0016051 Reactome: R-HSA-4085001 SHXM_RS34065 770d8eeebdf114601d6355be407069ef 249 Pfam PF03641 Possible lysine decarboxylase 113 241 1.8E-33 T 17-03-2017 IPR031100 LOG family SHXM_RS34065 770d8eeebdf114601d6355be407069ef 249 Gene3D G3DSA:3.40.50.450 52 245 2.3E-63 T 17-03-2017 SHXM_RS34065 770d8eeebdf114601d6355be407069ef 249 SUPERFAMILY SSF102405 42 243 7.94E-64 T 17-03-2017 SHXM_RS34065 770d8eeebdf114601d6355be407069ef 249 TIGRFAM TIGR00730 TIGR00730: TIGR00730 family protein 71 244 1.6E-42 T 17-03-2017 IPR005269 Cytokinin riboside 5'-monophosphate phosphoribohydrolase LOG SHXM_RS16850 c0a4820ed79e85b686862c9ce01bba36 348 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 35 211 2.4E-43 T 17-03-2017 IPR004302 Chitin-binding protein, N-terminal SHXM_RS16850 c0a4820ed79e85b686862c9ce01bba36 348 Gene3D G3DSA:2.70.50.50 35 214 3.4E-55 T 17-03-2017 SHXM_RS16850 c0a4820ed79e85b686862c9ce01bba36 348 SUPERFAMILY SSF81296 35 215 5.04E-51 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 Pfam PF13393 Histidyl-tRNA synthetase 9 309 6.8E-43 T 17-03-2017 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 SUPERFAMILY SSF55681 4 315 8.76E-81 T 17-03-2017 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 SUPERFAMILY SSF52954 326 419 5.07E-22 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 Pfam PF03129 Anticodon binding domain 329 416 1.8E-12 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 Gene3D G3DSA:3.30.930.10 3 185 1.5E-80 T 17-03-2017 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 Gene3D G3DSA:3.30.930.10 219 319 1.5E-80 T 17-03-2017 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 Hamap MF_00127 Histidine--tRNA ligase [hisS]. 2 417 30.439 T 17-03-2017 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 TIGRFAM TIGR00442 hisS: histidine--tRNA ligase 5 407 3.4E-130 T 17-03-2017 IPR015807 Histidine-tRNA ligase GO:0004821|GO:0005524|GO:0006427 KEGG: 00970+6.1.1.21 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 PIRSF PIRSF001549 1 419 1.0E-101 T 17-03-2017 IPR004516 Histidine-tRNA ligase/ATP phosphoribosyltransferase regulatory subunit GO:0005737 SHXM_RS12495 955e999d459e46357fa54850248ddff6 420 Gene3D G3DSA:3.40.50.800 327 417 7.8E-27 T 17-03-2017 IPR004154 Anticodon-binding SHXM_RS37520 716fb4e25eb16322817c136954d9a97b 468 SUPERFAMILY SSF63411 22 225 5.24E-39 T 17-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SHXM_RS37520 716fb4e25eb16322817c136954d9a97b 468 Pfam PF05193 Peptidase M16 inactive domain 193 381 5.0E-18 T 17-03-2017 IPR007863 Peptidase M16, C-terminal SHXM_RS37520 716fb4e25eb16322817c136954d9a97b 468 Gene3D G3DSA:3.30.830.10 29 235 3.3E-35 T 17-03-2017 IPR011237 Peptidase M16 domain GO:0046872 SHXM_RS37520 716fb4e25eb16322817c136954d9a97b 468 SUPERFAMILY SSF63411 255 458 4.44E-18 T 17-03-2017 IPR011249 Metalloenzyme, LuxS/M16 peptidase-like GO:0003824|GO:0046872 SHXM_RS37520 716fb4e25eb16322817c136954d9a97b 468 Pfam PF00675 Insulinase (Peptidase family M16) 43 171 7.3E-11 T 17-03-2017 IPR011765 Peptidase M16, N-terminal SHXM_RS37520 716fb4e25eb16322817c136954d9a97b 468 Gene3D G3DSA:3.30.830.10 255 448 6.0E-11 T 17-03-2017 IPR011237 Peptidase M16 domain GO:0046872 SHXM_RS16625 db075c172661c4805fa73fe5649d7d76 248 Pfam PF13649 Methyltransferase domain 41 135 4.4E-13 T 17-03-2017 SHXM_RS16625 db075c172661c4805fa73fe5649d7d76 248 SUPERFAMILY SSF53335 19 246 6.6E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16625 db075c172661c4805fa73fe5649d7d76 248 Gene3D G3DSA:3.40.50.150 20 245 7.7E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS08845 1a336d1655e830e933df64aca70a63aa 534 Gene3D G3DSA:3.40.1580.10 263 343 2.3E-5 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS08845 1a336d1655e830e933df64aca70a63aa 534 Gene3D G3DSA:3.40.1580.10 200 228 2.3E-5 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS08845 1a336d1655e830e933df64aca70a63aa 534 SMART SM00860 198 343 3.7E-10 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS08845 1a336d1655e830e933df64aca70a63aa 534 SUPERFAMILY SSF160631 196 345 2.22E-10 T 17-03-2017 SHXM_RS08845 1a336d1655e830e933df64aca70a63aa 534 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 201 341 2.0E-16 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS33910 b93727145f9532ab6512a14d8ec847c5 307 Gene3D G3DSA:1.10.3720.10 89 302 2.3E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33910 b93727145f9532ab6512a14d8ec847c5 307 SUPERFAMILY SSF161098 90 288 1.7E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33910 b93727145f9532ab6512a14d8ec847c5 307 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 306 5.5E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS14580 199a9757be3a67085cfda4351631bcdd 180 Gene3D G3DSA:1.20.120.520 32 140 9.7E-10 T 17-03-2017 SHXM_RS14580 199a9757be3a67085cfda4351631bcdd 180 Pfam PF01814 Hemerythrin HHE cation binding domain 78 131 1.2E-5 T 17-03-2017 IPR012312 Haemerythrin-like Reactome: R-HSA-390471 SHXM_RS14580 199a9757be3a67085cfda4351631bcdd 180 Pfam PF01814 Hemerythrin HHE cation binding domain 10 127 1.7E-13 T 17-03-2017 IPR012312 Haemerythrin-like Reactome: R-HSA-390471 SHXM_RS46560 b2a8a92626461ac926258c3e001a184b 87 Gene3D G3DSA:1.10.1200.10 37 82 3.1E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46560 b2a8a92626461ac926258c3e001a184b 87 SUPERFAMILY SSF47336 28 85 7.49E-8 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS46560 b2a8a92626461ac926258c3e001a184b 87 Pfam PF00550 Phosphopantetheine attachment site 37 81 2.7E-5 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS44350 79324bd0b4ed4fb717be7af8cb67a36f 163 TIGRFAM TIGR00040 yfcE: phosphodiesterase, MJ0936 family 2 152 4.3E-24 T 17-03-2017 IPR000979 Phosphodiesterase MJ0936/Vps29 Reactome: R-HSA-3238698 SHXM_RS44350 79324bd0b4ed4fb717be7af8cb67a36f 163 SUPERFAMILY SSF56300 2 160 3.3E-32 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS44350 79324bd0b4ed4fb717be7af8cb67a36f 163 Gene3D G3DSA:3.60.21.10 2 154 3.1E-29 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS44350 79324bd0b4ed4fb717be7af8cb67a36f 163 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 2 146 6.9E-22 T 17-03-2017 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 SHXM_RS47040 31c404187324122071bd1c9879e5eff2 151 Gene3D G3DSA:3.10.129.10 16 139 1.7E-34 T 17-03-2017 IPR029069 HotDog domain SHXM_RS47040 31c404187324122071bd1c9879e5eff2 151 SUPERFAMILY SSF54637 9 144 6.03E-35 T 17-03-2017 IPR029069 HotDog domain SHXM_RS47040 31c404187324122071bd1c9879e5eff2 151 Pfam PF01575 MaoC like domain 16 122 5.6E-26 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS41510 cfa72335788116948de221b289ade624 333 SUPERFAMILY SSF53474 38 330 1.55E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41510 cfa72335788116948de221b289ade624 333 Gene3D G3DSA:3.40.50.1820 52 327 4.7E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41510 cfa72335788116948de221b289ade624 333 Pfam PF12146 Serine aminopeptidase, S33 54 258 4.0E-18 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS02155 7e70f7eba6aabab5abb606db5be6e875 160 Pfam PF07977 FabA-like domain 13 142 6.2E-12 T 17-03-2017 IPR013114 Beta-hydroxydecanoyl thiol ester dehydrase, FabA/FabZ KEGG: 00061+4.2.1.59|KEGG: 00780+4.2.1.59|MetaCyc: PWY-5971|MetaCyc: PWY-5973|MetaCyc: PWY-5989|MetaCyc: PWY-5994|MetaCyc: PWY-6113|MetaCyc: PWY-6282|MetaCyc: PWY-6519|MetaCyc: PWY-7388|MetaCyc: PWY-7663|MetaCyc: PWY-7664|MetaCyc: PWYG-321 SHXM_RS02155 7e70f7eba6aabab5abb606db5be6e875 160 Gene3D G3DSA:3.10.129.10 4 149 1.1E-31 T 17-03-2017 IPR029069 HotDog domain SHXM_RS02155 7e70f7eba6aabab5abb606db5be6e875 160 SUPERFAMILY SSF54637 3 148 2.38E-25 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 SUPERFAMILY SSF52540 6 251 9.76E-77 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 ProSitePatterns PS00211 ABC transporters family signature. 152 166 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 Gene3D G3DSA:3.40.50.300 6 253 2.4E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 Pfam PF00005 ABC transporter 22 180 6.7E-37 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 PIRSF PIRSF039085 3 256 5.1E-100 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 SMART SM00382 31 229 7.2E-21 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS23000 a442fe7e36d2323960e5cba31da2b020 256 TIGRFAM TIGR03005 ectoine_ehuA: ectoine/hydroxyectoine ABC transporter, ATP-binding protein EhuA 7 256 3.8E-117 T 17-03-2017 IPR014343 Ectoine/hydroxyectoine ABC transporter, ATP-binding protein SHXM_RS50540 8271235895b37fcab7145687b731b411 278 SUPERFAMILY SSF161098 7 276 3.64E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50540 8271235895b37fcab7145687b731b411 278 Gene3D G3DSA:1.10.3720.10 4 266 6.7E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50540 8271235895b37fcab7145687b731b411 278 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 89 270 5.0E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23415 24438e1989122e4bd12eba5dd98e25ad 141 SMART SM00232 1 135 1.3E-25 T 17-03-2017 IPR000555 JAB1/MPN/MOV34 metalloenzyme domain GO:0005515 SHXM_RS23415 24438e1989122e4bd12eba5dd98e25ad 141 SUPERFAMILY SSF102712 1 134 6.41E-27 T 17-03-2017 SHXM_RS23415 24438e1989122e4bd12eba5dd98e25ad 141 Gene3D G3DSA:3.40.140.10 1 137 2.4E-35 T 17-03-2017 SHXM_RS23415 24438e1989122e4bd12eba5dd98e25ad 141 Pfam PF14464 Prokaryotic homologs of the JAB domain 6 114 1.1E-27 T 17-03-2017 IPR028090 JAB domain, prokaryotic SHXM_RS22715 11d577fcd95928794e543d453ceb189c 184 Gene3D G3DSA:3.30.750.24 73 164 2.8E-21 T 17-03-2017 IPR002645 STAS domain SHXM_RS22715 11d577fcd95928794e543d453ceb189c 184 Pfam PF13466 STAS domain 80 158 2.1E-17 T 17-03-2017 IPR002645 STAS domain SHXM_RS22715 11d577fcd95928794e543d453ceb189c 184 SUPERFAMILY SSF52091 72 164 2.75E-18 T 17-03-2017 IPR002645 STAS domain SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 SUPERFAMILY SSF56235 427 625 2.47E-123 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 SUPERFAMILY SSF56235 2 349 2.47E-123 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 Pfam PF01019 Gamma-glutamyltranspeptidase 28 619 9.7E-109 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 35 60 1.5E-16 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 105 123 1.5E-16 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 123 142 1.5E-16 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS32960 a71c42dd00fc91cdb217393c74e84554 626 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 484 499 1.5E-16 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS35410 4b301c34318b941905853163a5a29552 136 SUPERFAMILY SSF51278 7 124 3.14E-45 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35410 4b301c34318b941905853163a5a29552 136 Pfam PF00699 Urease beta subunit 7 100 5.3E-41 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35410 4b301c34318b941905853163a5a29552 136 TIGRFAM TIGR00192 urease_beta: urease, beta subunit 7 102 9.8E-41 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35410 4b301c34318b941905853163a5a29552 136 Hamap MF_01954 Urease subunit beta [ureB]. 1 102 29.476 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS35410 4b301c34318b941905853163a5a29552 136 Gene3D G3DSA:2.10.150.10 6 127 9.0E-49 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS27260 101b2d8e9b1a45c087d8adbdb3440061 474 ProSitePatterns PS00571 Amidases signature. 156 187 - T 17-03-2017 IPR020556 Amidase, conserved site KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921|Reactome: R-HSA-2142753 SHXM_RS27260 101b2d8e9b1a45c087d8adbdb3440061 474 Pfam PF01425 Amidase 29 453 1.9E-108 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS27260 101b2d8e9b1a45c087d8adbdb3440061 474 Gene3D G3DSA:3.90.1300.10 4 470 3.9E-139 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS27260 101b2d8e9b1a45c087d8adbdb3440061 474 SUPERFAMILY SSF75304 7 470 2.22E-137 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS11175 4ba87941e5cb4c7eecca89c4b6f42450 521 SUPERFAMILY SSF75304 46 509 7.98E-114 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS11175 4ba87941e5cb4c7eecca89c4b6f42450 521 Pfam PF01425 Amidase 68 493 7.1E-109 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS11175 4ba87941e5cb4c7eecca89c4b6f42450 521 Gene3D G3DSA:3.90.1300.10 45 511 1.3E-136 T 17-03-2017 IPR023631 Amidase signature domain KEGG: 00970+6.3.5.7|MetaCyc: PWY-5921 SHXM_RS47500 d62b4813d8556f60822711c6ce347e5b 240 Pfam PF00248 Aldo/keto reductase family 21 159 3.7E-28 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47500 d62b4813d8556f60822711c6ce347e5b 240 Pfam PF00248 Aldo/keto reductase family 153 214 3.1E-9 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47500 d62b4813d8556f60822711c6ce347e5b 240 SUPERFAMILY SSF51430 10 217 2.86E-54 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47500 d62b4813d8556f60822711c6ce347e5b 240 Gene3D G3DSA:3.20.20.100 157 227 7.6E-16 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47500 d62b4813d8556f60822711c6ce347e5b 240 Gene3D G3DSA:3.20.20.100 9 156 2.8E-46 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS01970 7c23d3e0a93ce4e67525c8f5840d6211 219 Gene3D G3DSA:1.10.3720.10 9 217 2.4E-34 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01970 7c23d3e0a93ce4e67525c8f5840d6211 219 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 49 218 2.4E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01970 7c23d3e0a93ce4e67525c8f5840d6211 219 SUPERFAMILY SSF161098 9 207 3.79E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23470 790b41bd718610c1208f2a6221569180 568 Pfam PF06271 RDD family 410 560 3.0E-21 T 17-03-2017 IPR010432 RDD SHXM_RS23470 790b41bd718610c1208f2a6221569180 568 Pfam PF10708 Protein of unknown function (DUF2510) 15 47 1.6E-10 T 17-03-2017 IPR018929 Domain of unknown function DUF2510 SHXM_RS03950 a61bd4dbcef57b1311863e87204f4147 440 TIGRFAM TIGR00791 gntP: transporter, gluconate:H+ symporter (GntP) family 1 440 6.1E-144 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS03950 a61bd4dbcef57b1311863e87204f4147 440 Pfam PF02447 GntP family permease 1 438 1.6E-140 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS03950 a61bd4dbcef57b1311863e87204f4147 440 PIRSF PIRSF002746 1 440 2.8E-137 T 17-03-2017 IPR003474 Gluconate transporter GO:0015128|GO:0016020|GO:0035429 SHXM_RS10850 4544650c6f7feb630dbc6c70b7758dfb 291 Gene3D G3DSA:1.10.260.40 15 73 4.7E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10850 4544650c6f7feb630dbc6c70b7758dfb 291 Pfam PF13560 Helix-turn-helix domain 18 79 3.2E-15 T 17-03-2017 SHXM_RS10850 4544650c6f7feb630dbc6c70b7758dfb 291 SUPERFAMILY SSF47413 13 73 2.06E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10850 4544650c6f7feb630dbc6c70b7758dfb 291 SMART SM00530 21 77 1.4E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Pfam PF17203 Single cache domain 3 37 172 1.1E-30 T 17-03-2017 IPR033463 Single cache domain 3 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 423 534 9.8E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 SUPERFAMILY SSF103190 42 171 2.28E-32 T 17-03-2017 IPR029151 Periplasmic sensor domain-like SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Gene3D G3DSA:3.30.565.10 383 537 2.1E-29 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 SMART SM00387 420 535 1.0E-24 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 SUPERFAMILY SSF55874 393 534 1.13E-27 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Gene3D G3DSA:1.10.287.130 310 365 7.8E-11 T 17-03-2017 IPR003661 Signal transduction histidine kinase, dimerisation/phosphoacceptor domain GO:0000155|GO:0007165 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 PRINTS PR00344 Bacterial sensor protein C-terminal signature 519 532 4.3E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 PRINTS PR00344 Bacterial sensor protein C-terminal signature 466 480 4.3E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 PRINTS PR00344 Bacterial sensor protein C-terminal signature 495 513 4.3E-10 T 17-03-2017 IPR004358 Signal transduction histidine kinase-related protein, C-terminal GO:0016310|GO:0016772 Reactome: R-HSA-70895 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Pfam PF13188 PAS domain 216 260 1.2E-4 T 17-03-2017 IPR000014 PAS domain SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Gene3D G3DSA:3.30.450.20 212 309 7.7E-8 T 17-03-2017 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 SUPERFAMILY SSF55785 208 311 1.02E-5 T 17-03-2017 IPR000014 PAS domain SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 SUPERFAMILY SSF55890 323 390 6.8E-5 T 17-03-2017 IPR016120 Signal transduction histidine kinase, sporulation regulator SpoOB GO:0000155|GO:0000160|GO:0016772 SHXM_RS35675 59f3f7fb481395bdc0f9c6bf0ee49850 540 Gene3D G3DSA:3.30.450.20 35 173 1.2E-41 T 17-03-2017 SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 Gene3D G3DSA:2.40.128.110 123 294 4.4E-50 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 SUPERFAMILY SSF101874 123 293 1.23E-45 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 Pfam PF13620 Carboxypeptidase regulatory-like domain 34 104 1.1E-8 T 17-03-2017 SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 SMART SM00867 124 293 2.9E-51 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 SUPERFAMILY SSF49464 35 116 2.9E-8 T 17-03-2017 IPR008969 Carboxypeptidase-like, regulatory domain SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 Pfam PF04264 YceI-like domain 125 292 5.9E-38 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS07655 0d9173a36bda22e23d0ffd88712de8cf 304 Gene3D G3DSA:2.60.40.1120 35 116 2.2E-9 T 17-03-2017 IPR014766 Carboxypeptidase, regulatory domain SHXM_RS14165 82894c497f6ea10204c4d2ec3efc762f 294 Gene3D G3DSA:3.20.20.150 10 283 1.1E-62 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14165 82894c497f6ea10204c4d2ec3efc762f 294 SUPERFAMILY SSF51658 9 286 1.83E-57 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14165 82894c497f6ea10204c4d2ec3efc762f 294 Pfam PF01261 Xylose isomerase-like TIM barrel 27 240 2.3E-35 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS26670 ec770967589ecbdcae31c7212c54cbf7 118 Pfam PF05239 PRC-barrel domain 7 75 2.1E-7 T 17-03-2017 IPR027275 PRC-barrel domain SHXM_RS26670 ec770967589ecbdcae31c7212c54cbf7 118 SUPERFAMILY SSF50346 5 107 1.2E-14 T 17-03-2017 IPR011033 PRC-barrel-like SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 Pfam PF00561 alpha/beta hydrolase fold 174 562 3.9E-24 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 SUPERFAMILY SSF53474 389 556 1.93E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 SUPERFAMILY SSF53474 165 219 1.93E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 SUPERFAMILY SSF53474 258 323 1.93E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 Gene3D G3DSA:3.40.50.1820 447 576 5.2E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 Gene3D G3DSA:3.40.50.1820 268 394 5.2E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS38295 46d1359b513310704ecfca688ba71177 617 Gene3D G3DSA:3.40.50.1820 138 224 5.2E-54 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 Pfam PF00766 Electron transfer flavoprotein FAD-binding domain 196 278 4.4E-36 T 17-03-2017 IPR014731 Electron transfer flavoprotein, alpha subunit, C-terminal Reactome: R-HSA-611105 SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 SUPERFAMILY SSF52467 194 314 1.03E-47 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 SUPERFAMILY SSF52402 3 187 1.67E-36 T 17-03-2017 SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 ProSitePatterns PS00696 Electron transfer flavoprotein alpha-subunit signature. 259 285 - T 17-03-2017 IPR018206 Electron transfer flavoprotein subunit alpha, conserved site Reactome: R-HSA-611105 SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 Gene3D G3DSA:3.40.50.620 3 185 2.7E-37 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 Gene3D G3DSA:3.40.50.1220 190 316 6.1E-59 T 17-03-2017 IPR029035 DHS-like NAD/FAD-binding domain SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 PIRSF PIRSF000089 1 320 4.5E-99 T 17-03-2017 IPR001308 Electron transfer flavoprotein alpha subunit/FixB GO:0009055|GO:0050660 Reactome: R-HSA-611105 SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 Pfam PF01012 Electron transfer flavoprotein domain 4 172 2.3E-29 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS43135 8c574ef7c43ebe573bab26a44d1fd46b 320 SMART SM00893 4 183 5.2E-24 T 17-03-2017 IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal Reactome: R-HSA-611105 SHXM_RS48250 79edafb27cc6dbc4c30f391625c71647 300 SUPERFAMILY SSF51197 19 299 6.41E-83 T 17-03-2017 SHXM_RS48250 79edafb27cc6dbc4c30f391625c71647 300 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 21 292 7.8E-59 T 17-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 SHXM_RS48250 79edafb27cc6dbc4c30f391625c71647 300 Gene3D G3DSA:3.60.130.10 12 299 8.2E-86 T 17-03-2017 SHXM_RS04270 f08faec75aee0aead6009ee0c7329caf 418 SUPERFAMILY SSF53756 17 403 4.71E-69 T 17-03-2017 SHXM_RS04270 f08faec75aee0aead6009ee0c7329caf 418 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 24 404 2.1E-48 T 17-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SHXM_RS04270 f08faec75aee0aead6009ee0c7329caf 418 Gene3D G3DSA:3.40.50.2000 230 385 7.8E-27 T 17-03-2017 SHXM_RS04270 f08faec75aee0aead6009ee0c7329caf 418 Gene3D G3DSA:3.40.50.2000 15 142 1.5E-21 T 17-03-2017 SHXM_RS04270 f08faec75aee0aead6009ee0c7329caf 418 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 288 376 5.3E-14 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS46825 4f4bfea34d547eb5105e72a01f7783b8 339 Gene3D G3DSA:3.40.50.1820 24 313 7.6E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46825 4f4bfea34d547eb5105e72a01f7783b8 339 TIGRFAM TIGR01840 esterase_phb: esterase, PHB depolymerase family 61 270 1.9E-65 T 17-03-2017 IPR010126 Esterase, PHB depolymerase GO:0005576|GO:0016787 SHXM_RS46825 4f4bfea34d547eb5105e72a01f7783b8 339 SUPERFAMILY SSF53474 38 146 3.57E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46825 4f4bfea34d547eb5105e72a01f7783b8 339 SUPERFAMILY SSF53474 288 337 6.14E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46825 4f4bfea34d547eb5105e72a01f7783b8 339 SUPERFAMILY SSF53474 146 261 6.14E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46825 4f4bfea34d547eb5105e72a01f7783b8 339 Pfam PF10503 Esterase PHB depolymerase 63 264 3.5E-38 T 17-03-2017 IPR010126 Esterase, PHB depolymerase GO:0005576|GO:0016787 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 Pfam PF13305 WHG domain 98 174 2.6E-12 T 17-03-2017 IPR025996 WHG domain SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 45 68 1.1E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 24 37 1.1E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 Gene3D G3DSA:1.10.357.10 72 193 7.1E-21 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 Pfam PF00440 Bacterial regulatory proteins, tetR family 24 70 1.3E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 Gene3D G3DSA:1.10.10.60 11 71 2.7E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 SUPERFAMILY SSF46689 15 85 2.94E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03450 ffadc7b536483f5cbe58233818e7357d 203 SUPERFAMILY SSF48498 95 194 2.18E-15 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11155 df80185eaba1114e9649da86f5fe1eb9 146 SUPERFAMILY SSF47413 46 84 1.72E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11155 df80185eaba1114e9649da86f5fe1eb9 146 Gene3D G3DSA:1.10.260.40 25 129 3.9E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11155 df80185eaba1114e9649da86f5fe1eb9 146 Pfam PF01381 Helix-turn-helix 27 81 1.1E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 SMART SM00382 29 212 1.2E-13 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 TIGRFAM TIGR01188 drrA: daunorubicin resistance ABC transporter, ATP-binding protein 12 309 3.0E-106 T 17-03-2017 IPR005894 Daunorubicin resistance ABC transporter ATP-binding subunit DrrA GO:0005524|GO:0043215|GO:1900753 SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 ProSitePatterns PS00211 ABC transporters family signature. 136 150 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 Gene3D G3DSA:3.40.50.300 2 228 2.8E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 Pfam PF13732 Domain of unknown function (DUF4162) 217 307 2.1E-8 T 17-03-2017 IPR025302 Domain of unknown function DUF4162 SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 SUPERFAMILY SSF52540 3 225 2.46E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37860 de9ce1394ad87f4f778cbf8d536e6472 325 Pfam PF00005 ABC transporter 20 163 7.5E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS45815 8a2ee108fe58aa5628f1ebd6b5c4efce 132 SUPERFAMILY SSF54637 4 130 1.12E-18 T 17-03-2017 IPR029069 HotDog domain SHXM_RS45815 8a2ee108fe58aa5628f1ebd6b5c4efce 132 Gene3D G3DSA:3.10.129.10 3 131 1.0E-17 T 17-03-2017 IPR029069 HotDog domain SHXM_RS49670 b7b3e19ef9bcf3ab1be50e6a9d903036 407 SUPERFAMILY SSF51735 1 168 9.76E-19 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49670 b7b3e19ef9bcf3ab1be50e6a9d903036 407 Pfam PF16653 Saccharopine dehydrogenase C-terminal domain 184 398 1.4E-17 T 17-03-2017 IPR032095 Saccharopine dehydrogenase, C-terminal Reactome: R-HSA-71064 SHXM_RS49670 b7b3e19ef9bcf3ab1be50e6a9d903036 407 Gene3D G3DSA:3.40.50.720 1 170 8.3E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49670 b7b3e19ef9bcf3ab1be50e6a9d903036 407 Pfam PF03435 Saccharopine dehydrogenase NADP binding domain 3 139 9.0E-20 T 17-03-2017 IPR005097 Saccharopine dehydrogenase, NADP binding domain GO:0016491|GO:0055114 SHXM_RS00910 191aa74dea590edddcf027413ca42bd6 481 SUPERFAMILY SSF54909 46 476 7.11E-122 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS00910 191aa74dea590edddcf027413ca42bd6 481 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 52 473 6.8E-33 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS32885 02380e5872be40d5471a3b50dbc0a00d 332 SMART SM00478 163 325 0.0072 T 17-03-2017 IPR003265 HhH-GPD domain GO:0006284 Reactome: R-HSA-110357 SHXM_RS32885 02380e5872be40d5471a3b50dbc0a00d 332 SUPERFAMILY SSF48150 143 321 1.19E-27 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS32885 02380e5872be40d5471a3b50dbc0a00d 332 Gene3D G3DSA:1.10.340.30 154 269 2.5E-21 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS23290 9e5b438695f625bc7ad1e662548ac91a 366 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 10 129 1.6E-22 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS23290 9e5b438695f625bc7ad1e662548ac91a 366 SUPERFAMILY SSF55347 138 291 1.26E-27 T 17-03-2017 SHXM_RS23290 9e5b438695f625bc7ad1e662548ac91a 366 Gene3D G3DSA:3.30.360.10 140 358 1.5E-36 T 17-03-2017 SHXM_RS23290 9e5b438695f625bc7ad1e662548ac91a 366 SUPERFAMILY SSF51735 7 166 2.05E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23290 9e5b438695f625bc7ad1e662548ac91a 366 Gene3D G3DSA:3.40.50.720 8 139 5.3E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23290 9e5b438695f625bc7ad1e662548ac91a 366 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 143 233 3.8E-13 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 Gene3D G3DSA:3.30.160.20 34 95 2.1E-28 T 17-03-2017 IPR014720 Double-stranded RNA-binding domain SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 Pfam PF00333 Ribosomal protein S5, N-terminal domain 36 98 5.2E-27 T 17-03-2017 IPR013810 Ribosomal protein S5, N-terminal GO:0003723|GO:0003735|GO:0005840|GO:0006412 SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 ProSitePatterns PS00585 Ribosomal protein S5 signature. 51 83 - T 17-03-2017 IPR018192 Ribosomal protein S5, N-terminal, conserved site SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 SUPERFAMILY SSF54211 102 181 2.53E-25 T 17-03-2017 IPR020568 Ribosomal protein S5 domain 2-type fold SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 TIGRFAM TIGR01021 rpsE_bact: ribosomal protein uS5 32 186 8.9E-68 T 17-03-2017 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 Pfam PF03719 Ribosomal protein S5, C-terminal domain 110 180 1.4E-29 T 17-03-2017 IPR005324 Ribosomal protein S5, C-terminal GO:0003735|GO:0005840|GO:0006412 SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 SUPERFAMILY SSF54768 33 99 1.46E-21 T 17-03-2017 SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 Gene3D G3DSA:3.30.230.10 101 181 1.3E-32 T 17-03-2017 IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup SHXM_RS31255 6fd52ee51480d498f42f334d58810b1d 201 Hamap MF_01307_B 30S ribosomal protein S5 [rpsE]. 4 186 34.797 T 17-03-2017 IPR005712 Ribosomal protein S5, bacterial-type GO:0003735|GO:0006412|GO:0015935 SHXM_RS41575 c351f712ee8b5ca0ff442238b7b23ad4 140 SUPERFAMILY SSF55874 45 128 7.11E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS41575 c351f712ee8b5ca0ff442238b7b23ad4 140 Pfam PF13581 Histidine kinase-like ATPase domain 21 118 1.7E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39120 aa2ea253dfa3cf34317e8553452c13e2 215 Pfam PF13483 Beta-lactamase superfamily domain 2 176 9.3E-23 T 17-03-2017 SHXM_RS39120 aa2ea253dfa3cf34317e8553452c13e2 215 SUPERFAMILY SSF56281 1 60 1.49E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS39120 aa2ea253dfa3cf34317e8553452c13e2 215 SUPERFAMILY SSF56281 87 180 1.49E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS39120 aa2ea253dfa3cf34317e8553452c13e2 215 Gene3D G3DSA:3.60.15.10 1 177 1.1E-25 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS39120 aa2ea253dfa3cf34317e8553452c13e2 215 SMART SM00849 7 176 9.7E-4 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS28650 a90600a43a37415520524540f43fb9d3 296 SUPERFAMILY SSF102114 16 271 6.15E-37 T 17-03-2017 SHXM_RS28650 a90600a43a37415520524540f43fb9d3 296 Gene3D G3DSA:3.20.20.70 15 267 2.2E-36 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS28650 a90600a43a37415520524540f43fb9d3 296 Pfam PF04055 Radical SAM superfamily 22 162 5.1E-13 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS16035 01645b73db887e760ace322b7c337688 344 Gene3D G3DSA:3.40.50.2300 35 151 1.3E-24 T 17-03-2017 SHXM_RS16035 01645b73db887e760ace322b7c337688 344 Pfam PF13407 Periplasmic binding protein domain 36 297 2.0E-50 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS16035 01645b73db887e760ace322b7c337688 344 Gene3D G3DSA:3.40.50.2300 152 306 2.4E-37 T 17-03-2017 SHXM_RS16035 01645b73db887e760ace322b7c337688 344 SUPERFAMILY SSF53822 35 333 4.4E-55 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS33400 72aca905cead02a95848abc33f13956b 75 Pfam PF04149 Domain of unknown function (DUF397) 16 68 2.0E-21 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS13800 cf358edd7eaf16564a44b9e202a81c62 39 SUPERFAMILY SSF51735 5 39 2.41E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13800 cf358edd7eaf16564a44b9e202a81c62 39 Gene3D G3DSA:3.40.50.720 3 39 9.3E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13800 cf358edd7eaf16564a44b9e202a81c62 39 Pfam PF00106 short chain dehydrogenase 9 38 1.1E-7 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS11870 846ef7bca032e3ae480b0a3525aaf0e4 358 Gene3D G3DSA:1.10.101.10 113 171 3.5E-12 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS11870 846ef7bca032e3ae480b0a3525aaf0e4 358 SUPERFAMILY SSF47090 108 171 2.62E-12 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS11870 846ef7bca032e3ae480b0a3525aaf0e4 358 Pfam PF01471 Putative peptidoglycan binding domain 120 171 2.6E-7 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 ProSitePatterns PS01108 Ribosomal protein L24 signature. 6 23 - T 17-03-2017 IPR005825 Ribosomal protein L24/L26, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 Pfam PF00467 KOW motif 5 36 2.9E-7 T 17-03-2017 IPR005824 KOW SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 SUPERFAMILY SSF50104 1 105 2.86E-30 T 17-03-2017 IPR008991 Translation protein SH3-like domain SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 Pfam PF17136 Ribosomal proteins 50S L24/mitochondrial 39S L24 38 107 2.6E-23 T 17-03-2017 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 TIGRFAM TIGR01079 rplX_bact: ribosomal protein uL24 1 107 9.7E-36 T 17-03-2017 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 Gene3D G3DSA:2.30.30.30 1 95 1.2E-25 T 17-03-2017 IPR014722 Ribosomal protein L2 domain 2 SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 SMART SM00739 2 29 2.1E-5 T 17-03-2017 IPR005824 KOW SHXM_RS31220 e7855d2a5a7c82b98a42f879b1aaa655 107 Hamap MF_01326_B 50S ribosomal protein L24 [rplX]. 1 101 21.516 T 17-03-2017 IPR003256 Ribosomal protein L24 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS00670 5b03496f9bb543f6acb08c17429dee79 267 Pfam PF07920 Protein of unknown function (DUF1684) 120 258 7.9E-23 T 17-03-2017 IPR012467 Protein of unknown function DUF1684 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 Pfam PF00696 Amino acid kinase family 31 272 1.1E-48 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 PRINTS PR00474 Glutamate 5-kinase family signature 195 222 5.7E-9 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 PRINTS PR00474 Glutamate 5-kinase family signature 246 266 5.7E-9 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 PRINTS PR00474 Glutamate 5-kinase family signature 62 76 5.7E-9 T 17-03-2017 IPR001057 Glutamate/acetylglutamate kinase GO:0006561 Reactome: R-HSA-70614 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 PIRSF PIRSF000728 16 295 1.1E-96 T 17-03-2017 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 Gene3D G3DSA:3.40.1160.10 29 295 4.2E-97 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 TIGRFAM TIGR00761 argB: acetylglutamate kinase 32 270 2.4E-71 T 17-03-2017 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 Hamap MF_00082_B Acetylglutamate kinase [argB]. 29 296 34.285 T 17-03-2017 IPR004662 Acetylglutamate kinase GO:0003991|GO:0005737|GO:0006526 KEGG: 00220+2.7.2.8|MetaCyc: PWY-5154|MetaCyc: PWY-7400 SHXM_RS12985 e627abe6388ad102ffc9e687b6d97133 319 SUPERFAMILY SSF53633 10 297 2.75E-85 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS05550 d9c715d502007665430ae1d3909bd3c0 387 SUPERFAMILY SSF56601 57 367 2.33E-68 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05550 d9c715d502007665430ae1d3909bd3c0 387 Pfam PF00144 Beta-lactamase 58 372 3.4E-55 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS05550 d9c715d502007665430ae1d3909bd3c0 387 Gene3D G3DSA:3.40.710.10 59 381 1.9E-68 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32750 3c480bb7a7a8fea8515773e98694358e 213 SUPERFAMILY SSF52980 39 166 1.88E-10 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS32750 3c480bb7a7a8fea8515773e98694358e 213 Pfam PF05685 Putative restriction endonuclease 37 171 6.0E-13 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS32750 3c480bb7a7a8fea8515773e98694358e 213 Gene3D G3DSA:3.90.1570.10 38 174 1.5E-10 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS34155 0a4254869cb46a39c3e8c5aa30cd8c59 366 Gene3D G3DSA:1.20.58.340 174 288 2.0E-39 T 17-03-2017 SHXM_RS34155 0a4254869cb46a39c3e8c5aa30cd8c59 366 Pfam PF01544 CorA-like Mg2+ transporter protein 66 356 1.2E-63 T 17-03-2017 IPR002523 Mg2+ transporter protein, CorA-like/Zinc transport protein ZntB GO:0016020|GO:0030001|GO:0046873|GO:0055085 SHXM_RS34155 0a4254869cb46a39c3e8c5aa30cd8c59 366 Gene3D G3DSA:1.20.58.340 290 366 2.1E-26 T 17-03-2017 SHXM_RS34155 0a4254869cb46a39c3e8c5aa30cd8c59 366 SUPERFAMILY SSF144083 302 363 7.32E-20 T 17-03-2017 SHXM_RS34155 0a4254869cb46a39c3e8c5aa30cd8c59 366 Gene3D G3DSA:3.30.460.20 20 173 1.3E-47 T 17-03-2017 SHXM_RS34155 0a4254869cb46a39c3e8c5aa30cd8c59 366 SUPERFAMILY SSF143865 29 297 1.44E-65 T 17-03-2017 SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 SUPERFAMILY SSF53474 63 322 4.61E-33 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 PRINTS PR00111 Alpha/beta hydrolase fold signature 152 165 7.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 PRINTS PR00111 Alpha/beta hydrolase fold signature 166 179 7.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 PRINTS PR00111 Alpha/beta hydrolase fold signature 109 124 7.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 PRINTS PR00111 Alpha/beta hydrolase fold signature 274 288 7.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 Gene3D G3DSA:3.40.50.1820 62 325 9.1E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11305 5b1ec90f5aba6a8e6ee568b37c51f6f2 374 Pfam PF00561 alpha/beta hydrolase fold 98 189 1.9E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 Gene3D G3DSA:2.40.30.10 8 86 4.4E-10 T 17-03-2017 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 PIRSF PIRSF006816 2 266 1.3E-61 T 17-03-2017 IPR012165 Cytochrome-c3 hydrogenase, gamma subunit GO:0006221|GO:0050660|GO:0051537 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 PRINTS PR00406 Cytochrome B5 reductase signature 84 98 6.9E-8 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 PRINTS PR00406 Cytochrome B5 reductase signature 146 157 6.9E-8 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 PRINTS PR00406 Cytochrome B5 reductase signature 197 205 6.9E-8 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 PRINTS PR00406 Cytochrome B5 reductase signature 108 127 6.9E-8 T 17-03-2017 IPR001834 NADH:cytochrome b5 reductase (CBR) GO:0016491|GO:0055114 Reactome: R-HSA-1237044 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 Gene3D G3DSA:3.40.50.80 87 223 5.8E-32 T 17-03-2017 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 Pfam PF00175 Oxidoreductase NAD-binding domain 110 211 5.5E-14 T 17-03-2017 IPR001433 Oxidoreductase FAD/NAD(P)-binding GO:0016491|GO:0055114 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 SUPERFAMILY SSF63380 4 94 3.76E-15 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 Pfam PF10418 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B 229 259 3.6E-6 T 17-03-2017 IPR019480 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 SUPERFAMILY SSF52343 103 244 1.06E-31 T 17-03-2017 SHXM_RS43450 34eb14900e92708693024ece7d5f52f3 270 Gene3D G3DSA:2.10.240.10 229 259 9.1E-8 T 17-03-2017 IPR019480 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain SHXM_RS14540 b006f3837a17693da538bb7ad126bec0 154 SUPERFAMILY SSF55961 1 148 2.31E-37 T 17-03-2017 SHXM_RS14540 b006f3837a17693da538bb7ad126bec0 154 Gene3D G3DSA:3.30.530.20 4 146 2.6E-19 T 17-03-2017 IPR023393 START-like domain SHXM_RS14540 b006f3837a17693da538bb7ad126bec0 154 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 6 138 1.5E-14 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS12825 8c22de47c2c4a4679055586060ba91d7 215 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 7 178 1.2E-22 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS12825 8c22de47c2c4a4679055586060ba91d7 215 Pfam PF13419 Haloacid dehalogenase-like hydrolase 8 178 4.9E-21 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12825 8c22de47c2c4a4679055586060ba91d7 215 SUPERFAMILY SSF56784 6 204 2.81E-46 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12825 8c22de47c2c4a4679055586060ba91d7 215 Gene3D G3DSA:3.40.50.1000 66 204 9.6E-48 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS12825 8c22de47c2c4a4679055586060ba91d7 215 TIGRFAM TIGR01549 HAD-SF-IA-v1: HAD hydrolase, family IA, variant 1 85 157 1.8E-7 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS26695 a5e02eb8265500cf612612aa2a50cc3f 152 Pfam PF14016 Protein of unknown function (DUF4232) 14 145 3.8E-24 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS09185 91459194272e7d0c94f59b4da126bd33 371 Gene3D G3DSA:3.40.640.10 36 262 2.3E-43 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS09185 91459194272e7d0c94f59b4da126bd33 371 Pfam PF00266 Aminotransferase class-V 62 300 2.5E-23 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS09185 91459194272e7d0c94f59b4da126bd33 371 SUPERFAMILY SSF53383 10 369 2.17E-58 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS09185 91459194272e7d0c94f59b4da126bd33 371 Gene3D G3DSA:3.90.1150.10 263 369 2.0E-5 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS28605 11e8d541c246528e49de8e9e24517bc2 203 Pfam PF03029 Conserved hypothetical ATP binding protein 24 186 1.7E-21 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS28605 11e8d541c246528e49de8e9e24517bc2 203 SUPERFAMILY SSF52540 17 192 4.98E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28605 11e8d541c246528e49de8e9e24517bc2 203 Gene3D G3DSA:3.40.50.300 15 195 3.1E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS32930 f79358dd2304d62478957a169e74cbd1 165 ProSitePatterns PS00669 Gas vesicles protein GVPa signature 2. 52 65 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS32930 f79358dd2304d62478957a169e74cbd1 165 Hamap MF_00576 Gas vesicle structural protein [gvpA]. 7 109 28.455 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS32930 f79358dd2304d62478957a169e74cbd1 165 ProSitePatterns PS00234 Gas vesicles protein GVPa signature 1. 19 33 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS32930 f79358dd2304d62478957a169e74cbd1 165 Pfam PF00741 Gas vesicle protein 18 56 2.4E-12 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS09600 8d7fffd14b3f1b407c97fd8009bf2135 257 Gene3D G3DSA:3.40.50.300 60 230 6.5E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS09600 8d7fffd14b3f1b407c97fd8009bf2135 257 SUPERFAMILY SSF52540 67 224 8.11E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS09600 8d7fffd14b3f1b407c97fd8009bf2135 257 Pfam PF01695 IstB-like ATP binding protein 58 231 3.5E-47 T 17-03-2017 IPR002611 IstB-like ATP-binding protein GO:0005524 SHXM_RS09600 8d7fffd14b3f1b407c97fd8009bf2135 257 PIRSF PIRSF003073 1 252 4.2E-78 T 17-03-2017 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SHXM_RS09600 8d7fffd14b3f1b407c97fd8009bf2135 257 SMART SM00382 100 231 5.4E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS23585 dc40ba6421f8e7547cb259511eadb0a1 65 SUPERFAMILY SSF47598 2 40 8.06E-9 T 17-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 SHXM_RS23585 dc40ba6421f8e7547cb259511eadb0a1 65 Pfam PF01402 Ribbon-helix-helix protein, copG family 3 38 1.6E-6 T 17-03-2017 IPR002145 Ribbon-helix-helix protein, CopG GO:0006355 SHXM_RS23585 dc40ba6421f8e7547cb259511eadb0a1 65 Gene3D G3DSA:1.10.1220.10 1 63 7.0E-13 T 17-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 SHXM_RS42605 68124e2655790fa1e76900ac0ffbc877 1275 Pfam PF12770 CHAT domain 961 1268 9.0E-40 T 17-03-2017 IPR024983 CHAT domain SHXM_RS32070 15d741de0cbcd3597a5a94db51cc3a2f 148 Gene3D G3DSA:2.60.120.10 13 133 5.3E-19 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS32070 15d741de0cbcd3597a5a94db51cc3a2f 148 SUPERFAMILY SSF51182 32 121 8.56E-16 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS32070 15d741de0cbcd3597a5a94db51cc3a2f 148 Pfam PF07883 Cupin domain 45 104 2.0E-12 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS28935 d0640918a6075f3f5b231589401fc17e 329 SUPERFAMILY SSF52540 5 224 4.47E-57 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28935 d0640918a6075f3f5b231589401fc17e 329 Gene3D G3DSA:3.40.50.300 4 225 4.1E-66 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28935 d0640918a6075f3f5b231589401fc17e 329 Pfam PF00005 ABC transporter 21 164 5.4E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS28935 d0640918a6075f3f5b231589401fc17e 329 SMART SM00382 30 220 6.2E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS28935 d0640918a6075f3f5b231589401fc17e 329 ProSitePatterns PS00211 ABC transporters family signature. 137 151 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS49000 bb00d90125024bb93354ea33c15e8c71 139 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 1 77 1.3E-13 T 17-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 SHXM_RS05705 4b257c99950b9b353f220517afbfe037 557 Pfam PF13751 Transposase DDE domain 403 527 3.2E-26 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS05705 4b257c99950b9b353f220517afbfe037 557 Pfam PF05598 Transposase domain (DUF772) 53 120 7.2E-17 T 17-03-2017 IPR008490 Transposase InsH, N-terminal SHXM_RS31100 8ea8c7aa17e1d89d29c63905a3c558f5 186 Hamap MF_00362 50S ribosomal protein L10 [rplJ]. 1 158 24.769 T 17-03-2017 IPR022973 Ribosomal protein L10 SHXM_RS31100 8ea8c7aa17e1d89d29c63905a3c558f5 186 SUPERFAMILY SSF160369 2 168 1.23E-50 T 17-03-2017 SHXM_RS31100 8ea8c7aa17e1d89d29c63905a3c558f5 186 Pfam PF00466 Ribosomal protein L10 3 98 1.0E-25 T 17-03-2017 IPR001790 Ribosomal protein L10P GO:0005622|GO:0042254 SHXM_RS01760 0ad3f4a50704cd13cb7c3e8e94788283 422 SUPERFAMILY SSF142764 21 399 1.23E-55 T 17-03-2017 SHXM_RS01760 0ad3f4a50704cd13cb7c3e8e94788283 422 Pfam PF07005 Putative sugar-binding N-terminal domain 21 233 3.9E-32 T 17-03-2017 IPR010737 Putative sugar-binding, N-terminal domain SHXM_RS01760 0ad3f4a50704cd13cb7c3e8e94788283 422 Pfam PF17042 Putative nucleotide-binding of sugar-metabolising enzyme 318 395 2.8E-13 T 17-03-2017 IPR031475 Putative nucleotide-binding C-terminal domain SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 SUPERFAMILY SSF49899 41 293 5.12E-74 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 SMART SM00458 300 424 3.8E-36 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 Pfam PF00722 Glycosyl hydrolases family 16 82 290 4.4E-42 T 17-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 Pfam PF00652 Ricin-type beta-trefoil lectin domain 301 421 2.1E-32 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 Gene3D G3DSA:2.60.120.200 43 293 3.0E-78 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 Gene3D G3DSA:2.80.10.50 295 423 1.5E-45 T 17-03-2017 SHXM_RS41675 0dee49027aec761bffcad21b29e33f31 425 SUPERFAMILY SSF50370 301 423 4.19E-42 T 17-03-2017 IPR000772 Ricin B, lectin domain SHXM_RS00675 47cff8a93e3981ce713817f6e3c417dd 297 SUPERFAMILY SSF53335 43 230 2.15E-35 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00675 47cff8a93e3981ce713817f6e3c417dd 297 Gene3D G3DSA:3.40.50.150 46 240 4.0E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00675 47cff8a93e3981ce713817f6e3c417dd 297 Pfam PF13649 Methyltransferase domain 64 161 4.2E-18 T 17-03-2017 SHXM_RS27025 f35fa45805f982d70fb6c155d6b1b806 451 SUPERFAMILY SSF52540 232 295 4.73E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27025 f35fa45805f982d70fb6c155d6b1b806 451 SUPERFAMILY SSF52540 19 190 4.73E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27025 f35fa45805f982d70fb6c155d6b1b806 451 Gene3D G3DSA:3.40.50.300 15 178 1.9E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27025 f35fa45805f982d70fb6c155d6b1b806 451 Gene3D G3DSA:3.40.50.300 219 295 1.9E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27025 f35fa45805f982d70fb6c155d6b1b806 451 Pfam PF02374 Anion-transporting ATPase 20 292 1.1E-26 T 17-03-2017 IPR025723 Anion-transporting ATPase-like domain Reactome: R-HSA-381038 SHXM_RS07420 3a2736ee6d863aa589f000e469dd3788 155 SUPERFAMILY SSF55874 57 149 9.83E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07420 3a2736ee6d863aa589f000e469dd3788 155 Pfam PF13581 Histidine kinase-like ATPase domain 32 145 4.3E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS07420 3a2736ee6d863aa589f000e469dd3788 155 Gene3D G3DSA:3.30.565.10 36 140 1.1E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22545 2cfddea5536b54e020126087afc9ea5b 307 SUPERFAMILY SSF53474 109 221 2.64E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22545 2cfddea5536b54e020126087afc9ea5b 307 Pfam PF06259 Alpha/beta hydrolase 91 252 9.0E-45 T 17-03-2017 IPR010427 Protein of unknown function DUF1023 SHXM_RS22545 2cfddea5536b54e020126087afc9ea5b 307 Gene3D G3DSA:3.40.50.1820 112 240 6.4E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09325 d6a0216a12559f700857c266344b829e 142 Pfam PF00078 Reverse transcriptase (RNA-dependent DNA polymerase) 51 140 6.5E-12 T 17-03-2017 IPR000477 Reverse transcriptase domain SHXM_RS09325 d6a0216a12559f700857c266344b829e 142 SUPERFAMILY SSF56672 50 138 2.31E-14 T 17-03-2017 SHXM_RS19045 9c114396e2e3c05d9fbdb291da8782dd 161 Gene3D G3DSA:3.40.630.30 2 160 3.0E-31 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19045 9c114396e2e3c05d9fbdb291da8782dd 161 SUPERFAMILY SSF55729 2 160 9.45E-33 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19045 9c114396e2e3c05d9fbdb291da8782dd 161 Pfam PF00583 Acetyltransferase (GNAT) family 52 133 5.4E-17 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS43240 71077838fef7e9ec6e5fa03ffe657b68 419 Pfam PF07690 Major Facilitator Superfamily 35 247 3.2E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS43240 71077838fef7e9ec6e5fa03ffe657b68 419 Pfam PF07690 Major Facilitator Superfamily 248 410 2.2E-10 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS43240 71077838fef7e9ec6e5fa03ffe657b68 419 Gene3D G3DSA:1.20.1250.20 31 195 1.5E-12 T 17-03-2017 SHXM_RS43240 71077838fef7e9ec6e5fa03ffe657b68 419 Gene3D G3DSA:1.20.1250.20 243 407 1.7E-17 T 17-03-2017 SHXM_RS43240 71077838fef7e9ec6e5fa03ffe657b68 419 SUPERFAMILY SSF103473 27 412 5.49E-38 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS30850 c6f7251cffe15b6d056af648a5a09508 407 Gene3D G3DSA:3.30.470.20 241 328 2.4E-10 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS30850 c6f7251cffe15b6d056af648a5a09508 407 Gene3D G3DSA:3.30.1490.20 130 214 3.0E-5 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS30850 c6f7251cffe15b6d056af648a5a09508 407 SUPERFAMILY SSF56059 135 341 4.95E-21 T 17-03-2017 SHXM_RS05580 758b60a5c1524a8c73de3a6a608687ab 314 Gene3D G3DSA:2.40.10.10 116 194 4.1E-11 T 17-03-2017 SHXM_RS05580 758b60a5c1524a8c73de3a6a608687ab 314 SUPERFAMILY SSF50494 116 287 5.16E-18 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS18545 a58b7e51de27cfadb8c7ba0575142c38 239 ProSitePatterns PS01211 Uncharacterized protein family UPF0001 signature. 80 94 - T 17-03-2017 IPR011078 Uncharacterised protein family UPF0001 SHXM_RS18545 a58b7e51de27cfadb8c7ba0575142c38 239 Pfam PF01168 Alanine racemase, N-terminal domain 12 236 2.5E-20 T 17-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS18545 a58b7e51de27cfadb8c7ba0575142c38 239 SUPERFAMILY SSF51419 4 233 1.23E-59 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS18545 a58b7e51de27cfadb8c7ba0575142c38 239 PIRSF PIRSF004848 1 239 1.0E-65 T 17-03-2017 IPR011078 Uncharacterised protein family UPF0001 SHXM_RS18545 a58b7e51de27cfadb8c7ba0575142c38 239 TIGRFAM TIGR00044 TIGR00044: pyridoxal phosphate enzyme, YggS family 9 235 4.5E-42 T 17-03-2017 IPR011078 Uncharacterised protein family UPF0001 SHXM_RS18545 a58b7e51de27cfadb8c7ba0575142c38 239 Gene3D G3DSA:3.20.20.10 3 236 1.1E-77 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS12650 49ccb90e9f528dc4baaa444725e32ce3 284 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 97 274 2.6E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12650 49ccb90e9f528dc4baaa444725e32ce3 284 Gene3D G3DSA:1.10.3720.10 9 271 6.6E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12650 49ccb90e9f528dc4baaa444725e32ce3 284 SUPERFAMILY SSF161098 9 284 8.88E-72 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS02840 1d098cdeb560c5d1d416f7a61d733797 426 SUPERFAMILY SSF142764 5 417 5.1E-125 T 17-03-2017 SHXM_RS02840 1d098cdeb560c5d1d416f7a61d733797 426 Pfam PF17042 Putative nucleotide-binding of sugar-metabolising enzyme 255 414 1.0E-41 T 17-03-2017 IPR031475 Putative nucleotide-binding C-terminal domain SHXM_RS02840 1d098cdeb560c5d1d416f7a61d733797 426 Pfam PF07005 Putative sugar-binding N-terminal domain 5 230 2.3E-70 T 17-03-2017 IPR010737 Putative sugar-binding, N-terminal domain SHXM_RS40685 5e3804f2c0d41ee74b6363247082dddb 335 Gene3D G3DSA:3.20.20.140 3 330 3.9E-83 T 17-03-2017 SHXM_RS40685 5e3804f2c0d41ee74b6363247082dddb 335 Pfam PF04909 Amidohydrolase 4 329 1.5E-47 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS40685 5e3804f2c0d41ee74b6363247082dddb 335 SUPERFAMILY SSF51556 3 329 9.83E-81 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS19195 27cf05353ccacc9f5220cfa818ffd245 201 Pfam PF00486 Transcriptional regulatory protein, C terminal 123 196 2.5E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS19195 27cf05353ccacc9f5220cfa818ffd245 201 SUPERFAMILY SSF46894 110 198 4.76E-26 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS19195 27cf05353ccacc9f5220cfa818ffd245 201 SMART SM00862 123 197 2.2E-23 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS19195 27cf05353ccacc9f5220cfa818ffd245 201 Gene3D G3DSA:1.10.10.10 110 199 3.2E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49800 46d1fa25b146dbfe6cc22129bfb204ab 297 SUPERFAMILY SSF51197 88 269 1.51E-19 T 17-03-2017 SHXM_RS49800 46d1fa25b146dbfe6cc22129bfb204ab 297 Gene3D G3DSA:2.60.120.330 109 267 2.3E-19 T 17-03-2017 IPR027443 Isopenicillin N synthase-like SHXM_RS49800 46d1fa25b146dbfe6cc22129bfb204ab 297 Pfam PF03171 2OG-Fe(II) oxygenase superfamily 163 238 1.4E-7 T 17-03-2017 IPR005123 Oxoglutarate/iron-dependent dioxygenase GO:0016491|GO:0055114 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 TIGRFAM TIGR00407 proA: glutamate-5-semialdehyde dehydrogenase 26 422 7.1E-156 T 17-03-2017 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 PIRSF PIRSF000151 14 432 6.9E-175 T 17-03-2017 IPR012134 Glutamate-5-semialdehyde dehydrogenase GO:0004350|GO:0006561|GO:0050661|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 Gene3D G3DSA:3.40.605.10 391 432 3.4E-104 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 Gene3D G3DSA:3.40.605.10 17 236 3.4E-104 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 Hamap MF_00412 Gamma-glutamyl phosphate reductase [proA]. 17 432 42.519 T 17-03-2017 IPR000965 GPR domain GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 Pfam PF00171 Aldehyde dehydrogenase family 20 324 3.8E-23 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 ProSitePatterns PS01223 Gamma-glutamyl phosphate reductase signature. 339 360 - T 17-03-2017 IPR020593 Gamma-glutamyl phosphate reductase GPR, conserved site GO:0004350|GO:0006561|GO:0055114 KEGG: 00330+1.2.1.41|KEGG: 00332+1.2.1.41|MetaCyc: PWY-3341|MetaCyc: PWY-6922|Reactome: R-HSA-70614 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 SUPERFAMILY SSF53720 18 432 1.23E-118 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS21575 46a50d6d6b63f0a26fc568de09017482 432 Gene3D G3DSA:3.40.309.10 239 390 6.6E-43 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS48730 71f87e4dd1da135520488e53745ff0ed 285 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 272 6.2E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48730 71f87e4dd1da135520488e53745ff0ed 285 SUPERFAMILY SSF161098 8 285 3.08E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48730 71f87e4dd1da135520488e53745ff0ed 285 Gene3D G3DSA:1.10.3720.10 7 273 2.0E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26070 110159e1a342fceb8feeb667e1410b3c 205 Gene3D G3DSA:3.40.430.10 4 184 1.7E-31 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS26070 110159e1a342fceb8feeb667e1410b3c 205 SUPERFAMILY SSF53597 3 183 5.76E-30 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS26070 110159e1a342fceb8feeb667e1410b3c 205 Pfam PF01872 RibD C-terminal domain 3 178 3.4E-22 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS47840 08dd92ee862e49c8e1e59d96564b995b 224 SUPERFAMILY SSF53474 4 216 2.53E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47840 08dd92ee862e49c8e1e59d96564b995b 224 Gene3D G3DSA:3.40.50.1820 4 217 3.4E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47840 08dd92ee862e49c8e1e59d96564b995b 224 Pfam PF12697 Alpha/beta hydrolase family 4 213 2.0E-12 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS33470 33211d060ebb86ea640d9925561c418e 312 Pfam PF00482 Type II secretion system (T2SS), protein F 145 268 9.5E-19 T 17-03-2017 IPR018076 Type II secretion system F domain SHXM_RS36645 588f6e57cd8d136492fd8ed3c985b702 179 Pfam PF00440 Bacterial regulatory proteins, tetR family 6 52 1.2E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36645 588f6e57cd8d136492fd8ed3c985b702 179 SUPERFAMILY SSF48498 73 178 3.19E-5 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS36645 588f6e57cd8d136492fd8ed3c985b702 179 Gene3D G3DSA:1.10.357.10 3 178 2.2E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS36645 588f6e57cd8d136492fd8ed3c985b702 179 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 6 19 4.7E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36645 588f6e57cd8d136492fd8ed3c985b702 179 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 27 50 4.7E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS36645 588f6e57cd8d136492fd8ed3c985b702 179 SUPERFAMILY SSF46689 3 69 4.74E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS26275 38f707de5b98fa59c8e693ca5f213953 818 SUPERFAMILY SSF52540 206 390 7.59E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26275 38f707de5b98fa59c8e693ca5f213953 818 Pfam PF05729 NACHT domain 213 373 1.2E-26 T 17-03-2017 SHXM_RS26275 38f707de5b98fa59c8e693ca5f213953 818 SMART SM00382 210 458 0.0068 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS26275 38f707de5b98fa59c8e693ca5f213953 818 Gene3D G3DSA:3.40.50.300 205 321 4.4E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14650 57e32923c50f2c8c73892ddbe66064dd 739 Gene3D G3DSA:1.25.40.10 652 683 9.6E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS14650 57e32923c50f2c8c73892ddbe66064dd 739 Gene3D G3DSA:1.25.40.10 480 551 9.6E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS14650 57e32923c50f2c8c73892ddbe66064dd 739 SUPERFAMILY SSF48452 478 551 2.47E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS14650 57e32923c50f2c8c73892ddbe66064dd 739 Pfam PF17128 Domain of unknown function (DUF5107) 59 351 3.2E-33 T 17-03-2017 IPR033396 Domain of unknown function DUF5107 SHXM_RS10675 7c2bc9b9e3f16e072747ac0335d8b30a 324 SUPERFAMILY SSF56112 27 276 1.58E-42 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS10675 7c2bc9b9e3f16e072747ac0335d8b30a 324 Pfam PF01636 Phosphotransferase enzyme family 30 263 3.4E-30 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS10675 7c2bc9b9e3f16e072747ac0335d8b30a 324 Gene3D G3DSA:3.90.1200.10 122 307 4.4E-26 T 17-03-2017 SHXM_RS36740 46f91503e47391a3437650061d916fae 483 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 283 294 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS36740 46f91503e47391a3437650061d916fae 483 Pfam PF00171 Aldehyde dehydrogenase family 19 478 2.4E-159 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS36740 46f91503e47391a3437650061d916fae 483 SUPERFAMILY SSF53720 5 481 4.97E-156 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS36740 46f91503e47391a3437650061d916fae 483 Gene3D G3DSA:3.40.309.10 270 458 4.9E-62 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS36740 46f91503e47391a3437650061d916fae 483 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 255 262 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS36740 46f91503e47391a3437650061d916fae 483 Gene3D G3DSA:3.40.605.10 8 269 3.6E-87 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 TIGRFAM TIGR01962 NuoD: NADH dehydrogenase (quinone), D subunit 42 444 2.1E-173 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 ProSitePatterns PS00535 Respiratory chain NADH dehydrogenase 49 Kd subunit signature. 79 90 - T 17-03-2017 IPR014029 NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 Hamap MF_01358 NAD(P)H-quinone oxidoreductase subunit H, chloroplastic [ndhH]. 38 444 46.866 T 17-03-2017 IPR022885 NAD(P)H-quinone oxidoreductase subunit D/H GO:0016651|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 Pfam PF00346 Respiratory-chain NADH dehydrogenase, 49 Kd subunit 159 444 1.2E-112 T 17-03-2017 IPR001135 NADH-quinone oxidoreductase, subunit D GO:0016651|GO:0048038|GO:0051287|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 Gene3D G3DSA:1.10.645.10 372 437 6.2E-68 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 Gene3D G3DSA:1.10.645.10 35 328 6.2E-68 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30770 035c13364035aa0dda3a4a422b8d8e1d 444 SUPERFAMILY SSF56762 52 444 4.71E-121 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS00960 57b198894c4b5b47bd684a9fba971468 390 Pfam PF07690 Major Facilitator Superfamily 18 349 1.8E-25 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS00960 57b198894c4b5b47bd684a9fba971468 390 Gene3D G3DSA:1.20.1250.20 17 188 5.3E-16 T 17-03-2017 SHXM_RS00960 57b198894c4b5b47bd684a9fba971468 390 Gene3D G3DSA:1.20.1250.20 210 387 6.1E-12 T 17-03-2017 SHXM_RS00960 57b198894c4b5b47bd684a9fba971468 390 SUPERFAMILY SSF103473 9 389 3.92E-44 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS11545 ba0adc0dcefc60eeefa1726f6b6f1686 114 Pfam PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L 6 109 8.6E-23 T 17-03-2017 IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K GO:0016651|GO:0042773|GO:0055114 SHXM_RS45670 8a5184ef74a85797b101763b81e4e397 219 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 72 1.3E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45670 8a5184ef74a85797b101763b81e4e397 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 4.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45670 8a5184ef74a85797b101763b81e4e397 219 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 4.4E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45670 8a5184ef74a85797b101763b81e4e397 219 SUPERFAMILY SSF46689 12 91 3.49E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45670 8a5184ef74a85797b101763b81e4e397 219 Gene3D G3DSA:1.10.357.10 10 207 1.8E-42 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS45670 8a5184ef74a85797b101763b81e4e397 219 SUPERFAMILY SSF48498 97 203 1.23E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS02180 d74c4f3ca69f32d338976b08dd9d1ff1 175 Pfam PF13160 Protein of unknown function (DUF3995) 26 153 1.6E-15 T 17-03-2017 IPR025058 Protein of unknown function DUF3995 SHXM_RS08350 5620733bc1431b3422ba905c0c604717 467 SUPERFAMILY SSF48452 226 332 5.22E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS08350 5620733bc1431b3422ba905c0c604717 467 Gene3D G3DSA:1.25.40.10 227 443 1.1E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39375 a2a360f2a67853b9a04aa21f1750c3b1 331 Gene3D G3DSA:3.40.50.720 7 127 1.1E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39375 a2a360f2a67853b9a04aa21f1750c3b1 331 SUPERFAMILY SSF51735 7 129 1.31E-15 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39375 a2a360f2a67853b9a04aa21f1750c3b1 331 SUPERFAMILY SSF55347 136 254 8.18E-10 T 17-03-2017 SHXM_RS39375 a2a360f2a67853b9a04aa21f1750c3b1 331 Gene3D G3DSA:3.30.360.10 136 320 1.2E-13 T 17-03-2017 SHXM_RS39375 a2a360f2a67853b9a04aa21f1750c3b1 331 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 24 118 5.5E-7 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS18705 7c462d71de8e204152aee7bf0cd59e0c 152 SUPERFAMILY SSF55961 7 148 1.01E-28 T 17-03-2017 SHXM_RS18705 7c462d71de8e204152aee7bf0cd59e0c 152 Gene3D G3DSA:3.30.530.20 6 148 1.2E-32 T 17-03-2017 IPR023393 START-like domain SHXM_RS18705 7c462d71de8e204152aee7bf0cd59e0c 152 Pfam PF08327 Activator of Hsp90 ATPase homolog 1-like protein 16 147 1.2E-20 T 17-03-2017 IPR013538 Activator of Hsp90 ATPase homologue 1-like GO:0006950 SHXM_RS00795 8d09a4f23ba1e6270c39b92e47ca4be2 126 SUPERFAMILY SSF55811 18 119 2.17E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS00795 8d09a4f23ba1e6270c39b92e47ca4be2 126 Pfam PF00293 NUDIX domain 21 118 3.5E-11 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS00795 8d09a4f23ba1e6270c39b92e47ca4be2 126 Gene3D G3DSA:3.90.79.10 15 119 7.6E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS00795 8d09a4f23ba1e6270c39b92e47ca4be2 126 ProSitePatterns PS00893 Nudix box signature. 49 70 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS33205 523b23b544d86e8c284b8070f739fcea 287 Pfam PF01061 ABC-2 type transporter 30 242 2.6E-27 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS33205 523b23b544d86e8c284b8070f739fcea 287 PIRSF PIRSF006648 2 287 9.9E-73 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS10020 2ad60cbe9ab32b6eef71d74c6674811c 274 Gene3D G3DSA:1.10.10.10 21 76 6.1E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10020 2ad60cbe9ab32b6eef71d74c6674811c 274 SUPERFAMILY SSF46785 22 89 4.93E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10020 2ad60cbe9ab32b6eef71d74c6674811c 274 Pfam PF01047 MarR family 33 71 1.3E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS49120 6237ea670e1dbeece05b6aaff6d40add 184 Gene3D G3DSA:3.40.50.850 9 180 6.3E-45 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS49120 6237ea670e1dbeece05b6aaff6d40add 184 SUPERFAMILY SSF52499 8 182 1.13E-47 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS49120 6237ea670e1dbeece05b6aaff6d40add 184 Pfam PF00857 Isochorismatase family 10 177 2.7E-39 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS24270 bf9189e5d7b637b7e382cfe4ca63f535 338 Gene3D G3DSA:3.90.550.10 7 240 3.6E-37 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24270 bf9189e5d7b637b7e382cfe4ca63f535 338 Pfam PF00535 Glycosyl transferase family 2 10 174 4.5E-22 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS24270 bf9189e5d7b637b7e382cfe4ca63f535 338 SUPERFAMILY SSF53448 2 248 1.88E-43 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS14490 55d14ec99c31e0d32625f8e9da2a578f 260 Gene3D G3DSA:3.40.50.1820 11 254 2.1E-39 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14490 55d14ec99c31e0d32625f8e9da2a578f 260 Pfam PF12697 Alpha/beta hydrolase family 30 249 7.6E-15 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS14490 55d14ec99c31e0d32625f8e9da2a578f 260 SUPERFAMILY SSF53474 11 256 1.23E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 SUPERFAMILY SSF48498 93 207 5.4E-24 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 4.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 26 39 4.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 SUPERFAMILY SSF46689 12 93 7.09E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 Gene3D G3DSA:1.10.357.10 68 208 3.3E-27 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 Gene3D G3DSA:1.10.10.60 12 67 2.6E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 Pfam PF00440 Bacterial regulatory proteins, tetR family 26 72 5.8E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS09615 1c2d962ff52e1435e48bce841e5176c1 211 Pfam PF16925 Bacterial transcriptional repressor C-terminal 95 193 5.3E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS31560 945d0db85d33477bc785ed5ae56b1630 104 Pfam PF02467 Transcription factor WhiB 17 87 9.9E-25 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS31560 945d0db85d33477bc785ed5ae56b1630 104 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 95 19.382 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS41630 fe0d00f025702c100676562ff72d93c1 325 Pfam PF03060 Nitronate monooxygenase 83 308 9.0E-40 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS41630 fe0d00f025702c100676562ff72d93c1 325 Pfam PF03060 Nitronate monooxygenase 3 73 3.9E-15 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS41630 fe0d00f025702c100676562ff72d93c1 325 SUPERFAMILY SSF51412 1 315 4.58E-49 T 17-03-2017 SHXM_RS41630 fe0d00f025702c100676562ff72d93c1 325 ProSitePatterns PS00912 Dihydroorotate dehydrogenase signature 2. 166 186 - T 17-03-2017 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 Reactome: R-HSA-500753 SHXM_RS41630 fe0d00f025702c100676562ff72d93c1 325 Gene3D G3DSA:3.20.20.70 1 304 3.9E-56 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS06000 c02dde649912d37e811d229951dc7fcb 362 Gene3D G3DSA:1.10.12.10 272 332 1.0E-4 T 17-03-2017 IPR014748 Crontonase, C-terminal SHXM_RS06000 c02dde649912d37e811d229951dc7fcb 362 Pfam PF16113 Enoyl-CoA hydratase/isomerase 28 348 7.5E-125 T 17-03-2017 IPR032259 Enoyl-CoA hydratase/isomerase, HIBYL-CoA-H type GO:0003860 Reactome: R-HSA-70895 SHXM_RS06000 c02dde649912d37e811d229951dc7fcb 362 Gene3D G3DSA:3.90.226.10 16 214 2.1E-61 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS06000 c02dde649912d37e811d229951dc7fcb 362 SUPERFAMILY SSF52096 261 331 1.36E-66 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS06000 c02dde649912d37e811d229951dc7fcb 362 SUPERFAMILY SSF52096 15 209 1.36E-66 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS50515 d6ba6bcfc397c8c35012f2608721ca9d 396 Pfam PF14307 Glycosyltransferase WbsX 28 388 3.1E-61 T 17-03-2017 IPR032719 Glycosyltransferase WbsX SHXM_RS42525 58e160475a02bead31f947d41f0b172b 336 SUPERFAMILY SSF53474 43 271 7.36E-33 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42525 58e160475a02bead31f947d41f0b172b 336 Gene3D G3DSA:3.40.50.1820 45 274 2.1E-38 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS42525 58e160475a02bead31f947d41f0b172b 336 Pfam PF12697 Alpha/beta hydrolase family 48 268 1.1E-20 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS09340 235c4c94d53efffe120a9b15a7e5f16b 118 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 9 86 1.4E-22 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS28115 e3a336a116c530f189594bbe7bf219b1 45 Pfam PF00468 Ribosomal protein L34 3 45 9.6E-20 T 17-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS28115 e3a336a116c530f189594bbe7bf219b1 45 ProSitePatterns PS00784 Ribosomal protein L34 signature. 3 22 - T 17-03-2017 IPR020939 Ribosomal protein L34, conserved site GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS28115 e3a336a116c530f189594bbe7bf219b1 45 TIGRFAM TIGR01030 rpmH_bact: ribosomal protein bL34 3 45 1.3E-19 T 17-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS28115 e3a336a116c530f189594bbe7bf219b1 45 Hamap MF_00391 50S ribosomal protein L34 [rpmH]. 2 45 15.594 T 17-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS28115 e3a336a116c530f189594bbe7bf219b1 45 ProDom PD003101 RIBOSOMAL L34 RIBONUCLEOPROTEIN 50S CHLOROPLAST PLASTID L34 MITOCHONDRIAL PEPTIDE SEQUENCING 3 40 3.0E-13 T 17-03-2017 IPR000271 Ribosomal protein L34 GO:0003735|GO:0005622|GO:0005840|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS43250 3bc60f1cdc546cd95e6f79961fdbce5a 195 Pfam PF16157 Domain of unknown function (DUF4865) 1 182 4.1E-71 T 17-03-2017 IPR032349 Protein of unknown function DUF4865 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 PRINTS PR00412 Epoxide hydrolase signature 79 97 5.3E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 PRINTS PR00412 Epoxide hydrolase signature 161 174 5.3E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 PRINTS PR00412 Epoxide hydrolase signature 99 114 5.3E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 PRINTS PR00412 Epoxide hydrolase signature 322 344 5.3E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 PRINTS PR00412 Epoxide hydrolase signature 147 160 5.3E-14 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 Pfam PF00561 alpha/beta hydrolase fold 73 329 1.8E-21 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 SUPERFAMILY SSF53474 52 343 6.06E-56 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04670 4016c17c3c9e6c76044fb0d2ac3207bf 350 Gene3D G3DSA:3.40.50.1820 40 343 4.1E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07215 4e6647f864aa6c09de37afd00ed03dd4 261 Pfam PF00975 Thioesterase domain 25 247 1.0E-48 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS07215 4e6647f864aa6c09de37afd00ed03dd4 261 Gene3D G3DSA:3.40.50.1820 15 253 1.2E-35 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07215 4e6647f864aa6c09de37afd00ed03dd4 261 SUPERFAMILY SSF53474 7 249 2.39E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 Gene3D G3DSA:3.40.190.10 187 269 1.6E-13 T 17-03-2017 SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 13 72 4.3E-19 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 Gene3D G3DSA:1.10.10.10 11 95 2.1E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 28 39 1.2E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 39 49 1.2E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 PRINTS PR00039 LysR bacterial regulatory protein HTH signature 49 60 1.2E-8 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 SUPERFAMILY SSF53850 99 306 6.21E-31 T 17-03-2017 SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 Pfam PF03466 LysR substrate binding domain 97 302 1.9E-29 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 SUPERFAMILY SSF46785 10 120 4.42E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40655 e81b846045b373be3080935b42a76ddc 313 Gene3D G3DSA:3.40.190.10 98 186 3.2E-15 T 17-03-2017 SHXM_RS43835 4d182c5f98dc11a67fd292bfe9ab556a 393 SUPERFAMILY SSF53850 45 392 9.75E-61 T 17-03-2017 SHXM_RS43835 4d182c5f98dc11a67fd292bfe9ab556a 393 Gene3D G3DSA:3.40.190.10 48 170 2.9E-11 T 17-03-2017 SHXM_RS43835 4d182c5f98dc11a67fd292bfe9ab556a 393 Pfam PF13416 Bacterial extracellular solute-binding protein 68 337 4.6E-29 T 17-03-2017 SHXM_RS43835 4d182c5f98dc11a67fd292bfe9ab556a 393 Gene3D G3DSA:3.40.190.10 171 323 1.1E-33 T 17-03-2017 SHXM_RS15545 b79d71f182327bce544ba3fbbd455985 365 SUPERFAMILY SSF46689 77 157 2.51E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15545 b79d71f182327bce544ba3fbbd455985 365 Pfam PF13683 Integrase core domain 264 328 7.6E-9 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15545 b79d71f182327bce544ba3fbbd455985 365 Gene3D G3DSA:3.30.420.10 172 329 2.0E-11 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15545 b79d71f182327bce544ba3fbbd455985 365 SUPERFAMILY SSF53098 177 331 2.28E-15 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS02115 78dd8c3e2b6b75ce4aaeff0c62c8d503 243 SUPERFAMILY SSF52833 7 205 2.28E-28 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS02115 78dd8c3e2b6b75ce4aaeff0c62c8d503 243 Gene3D G3DSA:3.40.30.10 6 198 2.5E-32 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS02115 78dd8c3e2b6b75ce4aaeff0c62c8d503 243 Pfam PF01323 DSBA-like thioredoxin domain 7 200 4.6E-17 T 17-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 SHXM_RS02115 78dd8c3e2b6b75ce4aaeff0c62c8d503 243 PIRSF PIRSF006386 1 210 5.8E-39 T 17-03-2017 IPR014440 HCCA isomerase/glutathione S-transferase kappa Reactome: R-HSA-156590 SHXM_RS14545 7fdc41750ad15a88b62e3590b9a3c1df 111 Pfam PF04673 Polyketide synthesis cyclase 5 107 3.3E-44 T 17-03-2017 IPR006765 Polyketide synthesis cyclase GO:0030639 SHXM_RS14545 7fdc41750ad15a88b62e3590b9a3c1df 111 Gene3D G3DSA:3.30.70.1090 4 109 1.8E-44 T 17-03-2017 IPR006765 Polyketide synthesis cyclase GO:0030639 SHXM_RS14545 7fdc41750ad15a88b62e3590b9a3c1df 111 ProDom PD012644 CYCLASE POLYKETIDE II SYNTHESIS ORF SYNTHASE JADI BIOSYNTHESIS ANTIBIOTIC CYCLASE-LIKE 4 107 1.0E-36 T 17-03-2017 IPR006765 Polyketide synthesis cyclase GO:0030639 SHXM_RS14545 7fdc41750ad15a88b62e3590b9a3c1df 111 SUPERFAMILY SSF54909 4 108 2.84E-38 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 SUPERFAMILY SSF46894 2 98 1.22E-11 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 SMART SM01043 105 250 1.5E-52 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 Pfam PF03704 Bacterial transcriptional activator domain 105 250 2.4E-46 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 SMART SM00862 15 98 4.2E-4 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 Gene3D G3DSA:1.25.40.10 109 224 4.8E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 Pfam PF00486 Transcriptional regulatory protein, C terminal 23 98 1.1E-7 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 SUPERFAMILY SSF48452 102 258 6.68E-38 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22900 79373b513bdfc14fa7a23b658106b9a3 274 Gene3D G3DSA:1.10.10.10 23 101 2.1E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49690 04a39a3ae55bcefecacc8ca893450846 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 80 291 9.3E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49690 04a39a3ae55bcefecacc8ca893450846 304 SUPERFAMILY SSF161098 63 286 8.9E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49690 04a39a3ae55bcefecacc8ca893450846 304 Gene3D G3DSA:1.10.3720.10 69 291 9.7E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40085 4228ca1dd116cc58593b32a2793d8f2e 213 SUPERFAMILY SSF52317 1 183 1.8E-45 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS40085 4228ca1dd116cc58593b32a2793d8f2e 213 Pfam PF01965 DJ-1/PfpI family 3 162 6.1E-27 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS40085 4228ca1dd116cc58593b32a2793d8f2e 213 Gene3D G3DSA:3.40.50.880 1 204 3.2E-61 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS25565 b72460f7f724cd003ef02d248c792e0e 251 Gene3D G3DSA:3.40.50.10490 9 246 8.4E-69 T 17-03-2017 SHXM_RS25565 b72460f7f724cd003ef02d248c792e0e 251 Hamap MF_01240 UPF0309 protein . 6 250 38.327 T 17-03-2017 IPR022951 Uncharacterised protein family UPF0309 SHXM_RS25565 b72460f7f724cd003ef02d248c792e0e 251 Pfam PF13580 SIS domain 9 146 1.2E-40 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS25565 b72460f7f724cd003ef02d248c792e0e 251 SUPERFAMILY SSF53697 9 204 1.8E-23 T 17-03-2017 SHXM_RS49155 1b9ee9e3c1191f202e4d1f63cf6e84f7 378 Pfam PF03747 ADP-ribosylglycohydrolase 38 343 4.3E-51 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS49155 1b9ee9e3c1191f202e4d1f63cf6e84f7 378 SUPERFAMILY SSF101478 32 352 8.5E-38 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS15675 cb0511f7a1ced3aeb3d1a0c109871c2a 362 SUPERFAMILY SSF46689 73 154 1.09E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15675 cb0511f7a1ced3aeb3d1a0c109871c2a 362 Gene3D G3DSA:3.30.420.10 168 326 1.4E-14 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15675 cb0511f7a1ced3aeb3d1a0c109871c2a 362 SUPERFAMILY SSF53098 173 328 2.73E-18 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15675 cb0511f7a1ced3aeb3d1a0c109871c2a 362 Pfam PF13683 Integrase core domain 263 326 4.0E-15 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS19625 910ffd481bc15fdb40c4f372120dfcb6 87 Gene3D G3DSA:3.30.40.10 7 86 5.7E-21 T 17-03-2017 IPR013083 Zinc finger, RING/FYVE/PHD-type SHXM_RS19625 910ffd481bc15fdb40c4f372120dfcb6 87 SUPERFAMILY SSF57850 7 86 2.12E-23 T 17-03-2017 SHXM_RS19625 910ffd481bc15fdb40c4f372120dfcb6 87 Pfam PF02148 Zn-finger in ubiquitin-hydrolases and other protein 23 84 9.5E-12 T 17-03-2017 IPR001607 Zinc finger, UBP-type GO:0008270 SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 Gene3D G3DSA:1.10.10.60 243 290 1.1E-10 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 Gene3D G3DSA:2.60.120.10 51 92 3.8E-6 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 SMART SM00342 205 288 4.3E-21 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 Pfam PF02311 AraC-like ligand binding domain 36 146 8.7E-6 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 SUPERFAMILY SSF51182 50 142 2.31E-5 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 SUPERFAMILY SSF46689 244 290 2.72E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03225 10d464f5af25faf2ddf7e60e8fff5d8d 296 Pfam PF12833 Helix-turn-helix domain 211 290 3.3E-19 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 252 316 2.1E-18 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 Pfam PF00005 ABC transporter 43 200 2.3E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 Gene3D G3DSA:3.40.50.300 24 273 8.3E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 SUPERFAMILY SSF52540 36 271 6.55E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 ProSitePatterns PS00211 ABC transporters family signature. 173 187 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 251 335 5.1E-20 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS03530 3c7e98f1ad41e6c6ca10ef5a97e07e02 355 SMART SM00382 51 249 2.2E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS40535 2c5b3e72ebd7ea3d314a84ac3f0ff0b7 446 Gene3D G3DSA:1.20.1250.20 235 429 7.3E-24 T 17-03-2017 SHXM_RS40535 2c5b3e72ebd7ea3d314a84ac3f0ff0b7 446 Gene3D G3DSA:1.20.1250.20 23 220 7.7E-21 T 17-03-2017 SHXM_RS40535 2c5b3e72ebd7ea3d314a84ac3f0ff0b7 446 SUPERFAMILY SSF103473 13 428 6.54E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS40535 2c5b3e72ebd7ea3d314a84ac3f0ff0b7 446 Pfam PF07690 Major Facilitator Superfamily 32 377 2.9E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS15510 fb2421f8499d3bcfe736342605f5f217 350 SUPERFAMILY SSF53795 234 262 5.49E-9 T 17-03-2017 SHXM_RS15510 fb2421f8499d3bcfe736342605f5f217 350 SUPERFAMILY SSF53795 125 173 5.49E-9 T 17-03-2017 SHXM_RS15510 fb2421f8499d3bcfe736342605f5f217 350 Gene3D G3DSA:3.40.50.300 125 255 9.3E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16390 9259e808f0778e14f0a0aba8d23ae133 444 Gene3D G3DSA:3.40.50.1820 226 347 1.1E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16390 9259e808f0778e14f0a0aba8d23ae133 444 Gene3D G3DSA:3.40.50.1820 41 50 1.1E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16390 9259e808f0778e14f0a0aba8d23ae133 444 SUPERFAMILY SSF53474 260 347 9.96E-8 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS35205 06c5983fd772dc01fe58b7d7897e4e7b 215 Pfam PF01300 Telomere recombination 23 197 6.5E-48 T 17-03-2017 IPR006070 YrdC-like domain GO:0003725 SHXM_RS35205 06c5983fd772dc01fe58b7d7897e4e7b 215 TIGRFAM TIGR00057 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family 13 207 2.8E-57 T 17-03-2017 IPR006070 YrdC-like domain GO:0003725 SHXM_RS35205 06c5983fd772dc01fe58b7d7897e4e7b 215 Gene3D G3DSA:3.90.870.10 8 205 2.5E-65 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS35205 06c5983fd772dc01fe58b7d7897e4e7b 215 SUPERFAMILY SSF55821 3 210 6.71E-58 T 17-03-2017 IPR017945 DHBP synthase RibB-like alpha/beta domain SHXM_RS41260 89709b98daef5f50c0b20aa2ca65a041 371 Pfam PF01594 Domain of unknown function DUF20 26 345 2.5E-59 T 17-03-2017 IPR002549 Transmembrane protein TqsA-like SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 Pfam PF00486 Transcriptional regulatory protein, C terminal 158 239 1.6E-21 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 SUPERFAMILY SSF52172 11 192 9.82E-38 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 SMART SM00862 157 239 1.3E-20 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 Gene3D G3DSA:3.40.50.2300 3 128 1.5E-35 T 17-03-2017 SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 SMART SM00448 10 121 7.3E-35 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 Pfam PF00072 Response regulator receiver domain 12 121 4.3E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS46015 d6eeabd0735fbe54b19601d795fb2ba8 248 Gene3D G3DSA:1.10.10.10 136 241 1.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS41440 d01a1f5faab8a46c62d539d734d6c9ff 323 SUPERFAMILY SSF56112 48 252 5.05E-23 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS41440 d01a1f5faab8a46c62d539d734d6c9ff 323 Gene3D G3DSA:3.90.1200.10 125 253 1.4E-9 T 17-03-2017 SHXM_RS41440 d01a1f5faab8a46c62d539d734d6c9ff 323 Pfam PF01636 Phosphotransferase enzyme family 82 255 3.0E-12 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS19880 3a146ef5b383738116bda65ca61d1d18 694 Pfam PF09594 Protein of unknown function (DUF2029) 55 290 4.7E-32 T 17-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 SHXM_RS19880 3a146ef5b383738116bda65ca61d1d18 694 Pfam PF14378 PAP2 superfamily 437 617 2.4E-49 T 17-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 SHXM_RS00695 241c24f944c6f4407214808ad968e34d 330 Pfam PF00248 Aldo/keto reductase family 16 309 9.3E-73 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS00695 241c24f944c6f4407214808ad968e34d 330 Gene3D G3DSA:3.20.20.100 1 314 5.0E-104 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS00695 241c24f944c6f4407214808ad968e34d 330 SUPERFAMILY SSF51430 1 311 5.89E-95 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS49875 ea7ef521f84cc88b2f598d93c4bc227e 239 Pfam PF00005 ABC transporter 30 184 2.5E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49875 ea7ef521f84cc88b2f598d93c4bc227e 239 TIGRFAM TIGR02324 CP_lyasePhnL: phosphonate C-P lyase system protein PhnL 8 227 9.4E-94 T 17-03-2017 IPR012701 Phosphonate C-P lyase system, PhnL KEGG: 00440+2.7.8.37|MetaCyc: PWY-7399 SHXM_RS49875 ea7ef521f84cc88b2f598d93c4bc227e 239 SMART SM00382 39 232 2.3E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49875 ea7ef521f84cc88b2f598d93c4bc227e 239 SUPERFAMILY SSF52540 25 229 7.06E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49875 ea7ef521f84cc88b2f598d93c4bc227e 239 Gene3D G3DSA:3.40.50.300 8 226 1.7E-48 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 130 138 2.5E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 76 87 2.5E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 2.5E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 11 206 3.0E-4 T 17-03-2017 SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 SUPERFAMILY SSF51735 12 253 1.84E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 19 253 2.0E-45 T 17-03-2017 SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 12 29 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 76 87 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 2.6E-39 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41185 5a0e31f9dda6b907b6401f5894d5d8c8 257 Gene3D G3DSA:3.40.50.720 7 253 2.3E-67 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS29800 b7680b3ddda989bc17861d0660b59989 404 Gene3D G3DSA:3.50.50.60 142 241 3.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29800 b7680b3ddda989bc17861d0660b59989 404 Gene3D G3DSA:3.50.50.60 5 88 3.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS29800 b7680b3ddda989bc17861d0660b59989 404 Gene3D G3DSA:3.30.9.10 276 294 1.3E-7 T 17-03-2017 SHXM_RS29800 b7680b3ddda989bc17861d0660b59989 404 Gene3D G3DSA:3.30.9.10 91 141 1.3E-7 T 17-03-2017 SHXM_RS29800 b7680b3ddda989bc17861d0660b59989 404 Pfam PF01266 FAD dependent oxidoreductase 7 395 2.1E-65 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS29800 b7680b3ddda989bc17861d0660b59989 404 SUPERFAMILY SSF51905 5 305 1.68E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS09135 0aa0ff6df6020bc3b23ca98a36f0d050 607 SUPERFAMILY SSF52540 273 441 5.33E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS09135 0aa0ff6df6020bc3b23ca98a36f0d050 607 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 289 314 9.0E-5 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS09135 0aa0ff6df6020bc3b23ca98a36f0d050 607 Gene3D G3DSA:3.40.50.300 278 425 6.3E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43035 7bf19e31ae7ca39482795623d1f6c99c 153 SMART SM00900 74 151 4.9E-15 T 17-03-2017 IPR007329 FMN-binding GO:0010181|GO:0016020 SHXM_RS43035 7bf19e31ae7ca39482795623d1f6c99c 153 Pfam PF04205 FMN-binding domain 76 148 4.0E-9 T 17-03-2017 IPR007329 FMN-binding GO:0010181|GO:0016020 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 Gene3D G3DSA:3.90.1150.10 342 434 2.2E-48 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 Gene3D G3DSA:3.90.1150.10 8 70 2.2E-48 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 Pfam PF00202 Aminotransferase class-III 29 432 1.9E-112 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 252 289 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 TIGRFAM TIGR00508 bioA: adenosylmethionine-8-amino-7-oxononanoate transaminase 18 433 2.0E-163 T 17-03-2017 IPR005815 Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA GO:0004015|GO:0009102 KEGG: 00780+2.6.1.62 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 SUPERFAMILY SSF53383 9 433 5.51E-114 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 Gene3D G3DSA:3.40.640.10 71 337 8.2E-82 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS08540 79e4255114fcd27992b2ac2b8922b880 438 Hamap MF_00834 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [bioA]. 6 437 48.624 T 17-03-2017 IPR005815 Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA GO:0004015|GO:0009102 KEGG: 00780+2.6.1.62 SHXM_RS15575 1a59963ee432f6329d49d7db95e6ee95 188 SUPERFAMILY SSF52540 8 176 2.67E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15575 1a59963ee432f6329d49d7db95e6ee95 188 Gene3D G3DSA:3.40.50.300 2 188 1.4E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15575 1a59963ee432f6329d49d7db95e6ee95 188 Pfam PF13671 AAA domain 6 155 1.5E-15 T 17-03-2017 SHXM_RS06305 b2ed76d4d5e68272df57af8523172a6d 284 Pfam PF12679 ABC-2 family transporter protein 22 282 4.8E-12 T 17-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 SHXM_RS35150 56f693d606c0196683e6110398b23582 140 Pfam PF00072 Response regulator receiver domain 5 115 5.1E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS35150 56f693d606c0196683e6110398b23582 140 SUPERFAMILY SSF52172 4 120 2.56E-34 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS35150 56f693d606c0196683e6110398b23582 140 Gene3D G3DSA:3.40.50.2300 4 121 5.9E-36 T 17-03-2017 SHXM_RS35150 56f693d606c0196683e6110398b23582 140 SMART SM00448 3 115 4.8E-30 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS00945 7ec7e41d1a3a2ceb42bef916ef209f31 234 Pfam PF01965 DJ-1/PfpI family 85 229 7.9E-13 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS00945 7ec7e41d1a3a2ceb42bef916ef209f31 234 SUPERFAMILY SSF52317 2 231 4.43E-59 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS00945 7ec7e41d1a3a2ceb42bef916ef209f31 234 Gene3D G3DSA:3.40.50.880 1 232 3.9E-75 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS48505 7a9e9dc1c948bc29d207600425aae41b 248 SUPERFAMILY SSF52317 4 248 1.37E-65 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS48505 7a9e9dc1c948bc29d207600425aae41b 248 Gene3D G3DSA:3.40.50.880 3 248 4.2E-84 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS48505 7a9e9dc1c948bc29d207600425aae41b 248 Pfam PF07090 Putative glutamine amidotransferase 3 247 3.4E-91 T 17-03-2017 IPR010768 Putative glutamine amidotransferase SHXM_RS33565 967f62fb33bd147a460368bc73dc949b 102 SUPERFAMILY SSF47598 15 69 6.67E-10 T 17-03-2017 IPR010985 Ribbon-helix-helix GO:0006355 SHXM_RS33565 967f62fb33bd147a460368bc73dc949b 102 Gene3D G3DSA:1.10.1220.10 17 59 4.9E-6 T 17-03-2017 IPR013321 Arc-type ribbon-helix-helix GO:0006355 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 Pfam PF00561 alpha/beta hydrolase fold 25 147 1.8E-23 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 Gene3D G3DSA:3.40.50.1820 8 277 4.7E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00412 Epoxide hydrolase signature 30 48 7.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00412 Epoxide hydrolase signature 50 65 7.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00412 Epoxide hydrolase signature 94 107 7.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00412 Epoxide hydrolase signature 255 277 7.3E-6 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 SUPERFAMILY SSF53474 7 276 4.42E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 50 65 1.2E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 94 107 1.2E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS06430 a8abda96093bf100d820b65311aa6545 288 PRINTS PR00111 Alpha/beta hydrolase fold signature 108 121 1.2E-6 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS37795 5761314b5a4e8c14d1d43aa9401d54f8 238 Gene3D G3DSA:3.40.30.10 9 204 1.9E-33 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS37795 5761314b5a4e8c14d1d43aa9401d54f8 238 SUPERFAMILY SSF52833 10 205 5.75E-28 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS37795 5761314b5a4e8c14d1d43aa9401d54f8 238 PIRSF PIRSF006386 3 214 5.7E-43 T 17-03-2017 IPR014440 HCCA isomerase/glutathione S-transferase kappa Reactome: R-HSA-156590 SHXM_RS37795 5761314b5a4e8c14d1d43aa9401d54f8 238 Pfam PF01323 DSBA-like thioredoxin domain 11 202 7.0E-20 T 17-03-2017 IPR001853 DSBA-like thioredoxin domain GO:0015035 Reactome: R-HSA-156590 SHXM_RS23715 67bb7482e744ab23265761f774a72f5c 253 Pfam PF13490 Putative zinc-finger 11 40 1.1E-7 T 17-03-2017 IPR027383 Putative zinc-finger SHXM_RS40450 f2a158161105b1e6b838bff017aa4458 205 SUPERFAMILY SSF56784 6 191 1.28E-26 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS40450 f2a158161105b1e6b838bff017aa4458 205 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 86 184 5.6E-10 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS40450 f2a158161105b1e6b838bff017aa4458 205 Gene3D G3DSA:3.40.50.1000 6 194 1.1E-28 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 ProSitePatterns PS00211 ABC transporters family signature. 159 173 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 SMART SM00382 26 232 6.7E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 SMART SM00382 350 515 1.1E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 ProSitePatterns PS00211 ABC transporters family signature. 443 457 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 Pfam PF12848 ABC transporter 231 302 2.2E-6 T 17-03-2017 IPR032781 ABC-transporter extension domain SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 SUPERFAMILY SSF52540 2 79 2.8E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 SUPERFAMILY SSF52540 128 234 2.8E-45 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 SUPERFAMILY SSF52540 330 517 2.85E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 Gene3D G3DSA:3.40.50.300 135 280 1.2E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 Gene3D G3DSA:3.40.50.300 3 99 1.2E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 Gene3D G3DSA:3.40.50.300 327 516 3.1E-43 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 Pfam PF00005 ABC transporter 19 187 4.7E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17485 cb7ff0f6b43234da494d6328793126e4 532 Pfam PF00005 ABC transporter 342 471 1.7E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS41890 22a0aa3270def0cfbf4ed339ac947ba9 269 SMART SM00849 45 252 1.1E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41890 22a0aa3270def0cfbf4ed339ac947ba9 269 Pfam PF00753 Metallo-beta-lactamase superfamily 44 252 2.4E-25 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41890 22a0aa3270def0cfbf4ed339ac947ba9 269 SUPERFAMILY SSF56281 5 254 6.16E-38 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS41890 22a0aa3270def0cfbf4ed339ac947ba9 269 Gene3D G3DSA:3.60.15.10 5 255 5.9E-38 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS30245 481ded64afdbc47d30ea7624f38cfa73 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 16 59 1.7E-18 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30245 481ded64afdbc47d30ea7624f38cfa73 192 SUPERFAMILY SSF46689 4 75 3.9E-20 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS30245 481ded64afdbc47d30ea7624f38cfa73 192 ProSitePatterns PS01081 TetR-type HTH domain signature. 26 57 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS30245 481ded64afdbc47d30ea7624f38cfa73 192 Gene3D G3DSA:1.10.357.10 5 184 1.4E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS30245 481ded64afdbc47d30ea7624f38cfa73 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 14 27 5.7E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30245 481ded64afdbc47d30ea7624f38cfa73 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 58 5.7E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 SMART SM00448 1 114 1.9E-38 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 SMART SM00862 159 231 3.9E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 Gene3D G3DSA:1.10.10.10 138 234 2.8E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 Pfam PF00486 Transcriptional regulatory protein, C terminal 159 231 5.0E-25 T 17-03-2017 IPR001867 OmpR/PhoB-type DNA-binding domain GO:0000160|GO:0003677|GO:0006355 SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 Gene3D G3DSA:3.40.50.2300 2 124 7.7E-37 T 17-03-2017 SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 SUPERFAMILY SSF52172 2 193 3.42E-37 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS37285 cbd7d55121369708a0d80dfe742ee030 236 Pfam PF00072 Response regulator receiver domain 4 114 6.1E-25 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 Gene3D G3DSA:3.40.47.10 273 388 6.7E-48 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 Gene3D G3DSA:3.40.47.10 148 184 6.7E-48 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 Gene3D G3DSA:3.40.47.10 6 125 8.3E-58 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 Gene3D G3DSA:3.40.47.10 185 272 8.3E-58 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 Pfam PF02803 Thiolase, C-terminal domain 267 388 3.6E-41 T 17-03-2017 IPR020617 Thiolase, C-terminal GO:0008152|GO:0016747 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 ProSitePatterns PS00737 Thiolases signature 2. 335 351 - T 17-03-2017 IPR020613 Thiolase, conserved site GO:0008152|GO:0016747 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 SUPERFAMILY SSF53901 5 266 7.27E-62 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 PIRSF PIRSF000429 1 389 3.0E-114 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 SUPERFAMILY SSF53901 267 388 2.65E-38 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 ProSitePatterns PS00099 Thiolases active site. 370 383 - T 17-03-2017 IPR020610 Thiolase, active site GO:0008152|GO:0016747 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 Pfam PF00108 Thiolase, N-terminal domain 6 257 2.6E-51 T 17-03-2017 IPR020616 Thiolase, N-terminal GO:0008152|GO:0016747 SHXM_RS19860 28fc0a9997912d94600b2b74ca74bf79 389 TIGRFAM TIGR01930 AcCoA-C-Actrans: acetyl-CoA C-acyltransferase 7 387 5.4E-115 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 SUPERFAMILY SSF55447 185 281 1.31E-18 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 SMART SM01092 182 279 2.7E-19 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 SUPERFAMILY SSF56176 1 177 1.21E-46 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 Pfam PF03450 CO dehydrogenase flavoprotein C-terminal domain 186 278 8.5E-14 T 17-03-2017 IPR005107 CO dehydrogenase flavoprotein, C-terminal SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 Gene3D G3DSA:3.30.465.10 59 177 3.5E-30 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 Gene3D G3DSA:3.30.390.50 181 282 8.0E-23 T 17-03-2017 SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 5 177 2.2E-41 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS01365 6f1d69efa9d562a29a47ea214e760372 282 Gene3D G3DSA:3.30.43.10 1 54 6.6E-22 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS50435 0951bebc175857f05c7e8ebb7ad28135 387 SUPERFAMILY SSF52266 180 381 1.83E-17 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS50435 0951bebc175857f05c7e8ebb7ad28135 387 Gene3D G3DSA:3.40.50.1110 185 383 6.9E-15 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS50435 0951bebc175857f05c7e8ebb7ad28135 387 Pfam PF00657 GDSL-like Lipase/Acylhydrolase 187 372 4.6E-9 T 17-03-2017 IPR001087 GDSL lipase/esterase GO:0016788 SHXM_RS34025 20b0cf311a75464e59e04dd1041b23ab 278 Pfam PF13371 Tetratricopeptide repeat 196 278 1.4E-14 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS34025 20b0cf311a75464e59e04dd1041b23ab 278 Pfam PF13369 Transglutaminase-like superfamily 49 194 2.8E-42 T 17-03-2017 IPR032698 Protein SirB1, N-terminal SHXM_RS28815 d126065b8852c36aaf2af5631a329cec 143 Pfam PF00293 NUDIX domain 7 116 5.1E-18 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS28815 d126065b8852c36aaf2af5631a329cec 143 SUPERFAMILY SSF55811 3 123 6.23E-27 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS28815 d126065b8852c36aaf2af5631a329cec 143 Gene3D G3DSA:3.90.79.10 5 125 1.1E-26 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS44935 f74d03165da754966c9160827d1177d5 506 Pfam PF13520 Amino acid permease 36 471 5.7E-63 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS44935 f74d03165da754966c9160827d1177d5 506 PIRSF PIRSF006060 15 503 1.1E-62 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS44935 f74d03165da754966c9160827d1177d5 506 ProSitePatterns PS00218 Amino acid permeases signature. 63 94 - T 17-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 SMART SM00282 458 593 2.4E-7 T 17-03-2017 IPR001791 Laminin G domain SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 SUPERFAMILY SSF50939 36 398 7.29E-87 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 Pfam PF13088 BNR repeat-like domain 61 349 1.3E-28 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 SUPERFAMILY SSF49899 407 602 8.76E-33 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 Pfam PF13385 Concanavalin A-like lectin/glucanases superfamily 439 600 6.3E-23 T 17-03-2017 SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 Gene3D G3DSA:2.60.120.200 426 602 2.7E-29 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 SMART SM00560 458 598 2.0E-16 T 17-03-2017 IPR006558 LamG-like jellyroll fold SHXM_RS14280 4ffb08163e8168b5cbfe0c85edecc114 631 Gene3D G3DSA:2.120.10.10 43 401 1.9E-89 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS39875 fadd7a27990627ba906bbe069ec8ca59 256 SUPERFAMILY SSF55729 1 115 1.1E-8 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS39875 fadd7a27990627ba906bbe069ec8ca59 256 Gene3D G3DSA:3.40.630.30 3 113 1.3E-6 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS09695 3daba95a56388864385801e74fd458ba 119 Pfam PF05331 Protein of unknown function (DUF742) 9 119 6.6E-20 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS12215 90cff393769b60d4bcefd72e8de2ad5c 285 SUPERFAMILY SSF47413 28 80 3.56E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12215 90cff393769b60d4bcefd72e8de2ad5c 285 SMART SM00530 9 81 4.4E-9 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS12215 90cff393769b60d4bcefd72e8de2ad5c 285 Gene3D G3DSA:1.10.260.40 4 80 3.3E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12215 90cff393769b60d4bcefd72e8de2ad5c 285 Pfam PF13560 Helix-turn-helix domain 5 84 1.1E-18 T 17-03-2017 SHXM_RS21445 e4acafebccb960c925753047a49227cf 444 Pfam PF00805 Pentapeptide repeats (8 copies) 281 320 1.0E-12 T 17-03-2017 IPR001646 Pentapeptide repeat SHXM_RS21445 e4acafebccb960c925753047a49227cf 444 Pfam PF00805 Pentapeptide repeats (8 copies) 351 390 2.7E-10 T 17-03-2017 IPR001646 Pentapeptide repeat SHXM_RS21445 e4acafebccb960c925753047a49227cf 444 SUPERFAMILY SSF141571 265 413 1.28E-36 T 17-03-2017 SHXM_RS28995 a1a9c49a9adcad7a932f69a98e9f9d44 244 Pfam PF14016 Protein of unknown function (DUF4232) 104 225 4.0E-14 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS15635 9cfe20de1863029a871f568cc7c6bd4d 427 SMART SM00530 9 64 3.9E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS15635 9cfe20de1863029a871f568cc7c6bd4d 427 Gene3D G3DSA:1.10.260.40 6 58 1.1E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15635 9cfe20de1863029a871f568cc7c6bd4d 427 Pfam PF13560 Helix-turn-helix domain 6 67 4.5E-11 T 17-03-2017 SHXM_RS15635 9cfe20de1863029a871f568cc7c6bd4d 427 SUPERFAMILY SSF48452 271 378 1.27E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS15635 9cfe20de1863029a871f568cc7c6bd4d 427 SUPERFAMILY SSF47413 4 58 1.1E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38375 126bc741be132c3e771abf023d6454cf 169 Gene3D G3DSA:2.30.110.10 10 164 1.5E-55 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS38375 126bc741be132c3e771abf023d6454cf 169 SUPERFAMILY SSF50475 13 165 2.01E-47 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS38375 126bc741be132c3e771abf023d6454cf 169 Pfam PF01613 Flavin reductase like domain 22 166 9.8E-39 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS38375 126bc741be132c3e771abf023d6454cf 169 SMART SM00903 21 165 3.1E-55 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 Gene3D G3DSA:1.25.40.10 353 582 1.9E-26 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 Pfam PF13424 Tetratricopeptide repeat 353 424 1.6E-10 T 17-03-2017 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 SMART SM00028 553 586 43.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 SMART SM00028 353 386 0.017 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 SMART SM00028 473 506 28.0 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 SMART SM00028 393 426 0.37 T 17-03-2017 IPR019734 Tetratricopeptide repeat GO:0005515 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 SUPERFAMILY SSF52540 8 161 8.5E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 Pfam PF13374 Tetratricopeptide repeat 433 466 0.013 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS50890 715a0e6a97877e1cd5976132b124cd5b 604 SUPERFAMILY SSF48452 349 504 1.4E-23 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 ProSitePatterns PS00136 Serine proteases, subtilase family, aspartic acid active site. 209 220 - T 17-03-2017 IPR023827 Peptidase S8, subtilisin, Asp-active site SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 PRINTS PR00723 Subtilisin serine protease family (S8) signature 418 434 1.2E-21 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 PRINTS PR00723 Subtilisin serine protease family (S8) signature 241 254 1.2E-21 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 PRINTS PR00723 Subtilisin serine protease family (S8) signature 204 223 1.2E-21 T 17-03-2017 IPR015500 Peptidase S8, subtilisin-related SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 SUPERFAMILY SSF52743 185 477 3.4E-84 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 Gene3D G3DSA:3.40.50.200 165 476 3.8E-88 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 SUPERFAMILY SSF52025 769 869 4.84E-10 T 17-03-2017 SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 ProSitePatterns PS00138 Serine proteases, subtilase family, serine active site. 419 429 - T 17-03-2017 IPR023828 Peptidase S8, subtilisin, Ser-active site SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 Pfam PF00082 Subtilase family 204 467 7.0E-57 T 17-03-2017 IPR000209 Peptidase S8/S53 domain GO:0004252|GO:0006508 SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 Gene3D G3DSA:3.50.30.30 751 867 3.0E-11 T 17-03-2017 SHXM_RS13625 09f3c5abe08dc5fa0a0d1710a4ead418 1223 Pfam PF02225 PA domain 782 861 9.3E-8 T 17-03-2017 IPR003137 PA domain SHXM_RS08145 829df5f45a880b52da893141ee1c86c5 213 Pfam PF13628 Domain of unknown function (DUF4142) 69 203 1.2E-16 T 17-03-2017 IPR025419 Domain of unknown function DUF4142 SHXM_RS13455 79542aea3aba2beb2e6862def52dd99f 170 Pfam PF13581 Histidine kinase-like ATPase domain 35 135 5.7E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13455 79542aea3aba2beb2e6862def52dd99f 170 Gene3D G3DSA:3.30.565.10 67 163 6.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13455 79542aea3aba2beb2e6862def52dd99f 170 SUPERFAMILY SSF55874 46 159 2.1E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS39745 e8f9fc4752a5aa4350cb19245f7ffc7a 320 Pfam PF04909 Amidohydrolase 35 320 9.8E-49 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS39745 e8f9fc4752a5aa4350cb19245f7ffc7a 320 SUPERFAMILY SSF51556 40 320 2.72E-77 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS39745 e8f9fc4752a5aa4350cb19245f7ffc7a 320 Gene3D G3DSA:3.20.20.140 20 320 5.4E-88 T 17-03-2017 SHXM_RS19100 1caff61c69116eedfa4785edf0975635 155 PIRSF PIRSF021697 3 155 1.7E-46 T 17-03-2017 IPR016795 Uncharacterised conserved protein UCP021697, membrane SHXM_RS19100 1caff61c69116eedfa4785edf0975635 155 Pfam PF06271 RDD family 43 148 1.2E-10 T 17-03-2017 IPR010432 RDD SHXM_RS17720 3866333884cbde33e75459b6fab8c4e0 269 Gene3D G3DSA:3.40.50.720 4 213 1.1E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17720 3866333884cbde33e75459b6fab8c4e0 269 SUPERFAMILY SSF51735 1 238 1.66E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17720 3866333884cbde33e75459b6fab8c4e0 269 Pfam PF01370 NAD dependent epimerase/dehydratase family 7 167 1.4E-20 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS43285 d1eb80511e9224d16fcb3af4a3679013 816 SUPERFAMILY SSF53474 590 711 2.26E-9 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS15920 84fb375ccf6e585ffc13507e71cc24a6 72 Pfam PF05639 Pup-like protein 4 72 1.8E-30 T 17-03-2017 IPR008515 Ubiquitin-like, Pup SHXM_RS15920 84fb375ccf6e585ffc13507e71cc24a6 72 Hamap MF_02106 Prokaryotic ubiquitin-like protein Pup [pup]. 1 72 17.69 T 17-03-2017 IPR008515 Ubiquitin-like, Pup SHXM_RS15920 84fb375ccf6e585ffc13507e71cc24a6 72 TIGRFAM TIGR03687 pupylate_cterm: ubiquitin-like protein Pup 41 72 2.9E-21 T 17-03-2017 IPR008515 Ubiquitin-like, Pup SHXM_RS01920 fecfbf34a610c25c3cd04fda1de82f25 479 SUPERFAMILY SSF103473 2 193 2.35E-52 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS01920 fecfbf34a610c25c3cd04fda1de82f25 479 SUPERFAMILY SSF103473 242 453 2.35E-52 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS01920 fecfbf34a610c25c3cd04fda1de82f25 479 Pfam PF07690 Major Facilitator Superfamily 8 405 9.2E-41 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS01920 fecfbf34a610c25c3cd04fda1de82f25 479 Gene3D G3DSA:1.20.1250.20 2 190 2.7E-27 T 17-03-2017 SHXM_RS01920 fecfbf34a610c25c3cd04fda1de82f25 479 Gene3D G3DSA:1.20.1250.20 262 451 2.9E-14 T 17-03-2017 SHXM_RS13695 f218c36fa4abe3c48714748fa3ffe5c0 779 Gene3D G3DSA:1.50.10.10 426 615 4.9E-10 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS13695 f218c36fa4abe3c48714748fa3ffe5c0 779 SUPERFAMILY SSF48208 260 710 1.34E-40 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS07605 a4dc280a977000d5b0c9a3a8802f761c 403 Gene3D G3DSA:3.30.1540.10 230 311 6.9E-10 T 17-03-2017 SHXM_RS07605 a4dc280a977000d5b0c9a3a8802f761c 403 Gene3D G3DSA:3.40.50.10540 9 224 1.5E-91 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS07605 a4dc280a977000d5b0c9a3a8802f761c 403 Gene3D G3DSA:3.40.50.10540 312 403 1.5E-91 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS07605 a4dc280a977000d5b0c9a3a8802f761c 403 SUPERFAMILY SSF89796 10 403 2.35E-103 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS07605 a4dc280a977000d5b0c9a3a8802f761c 403 Pfam PF02515 CoA-transferase family III 12 379 1.3E-104 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS18840 0394d578123cabad11de0207610cc6c1 453 Pfam PF05991 YacP-like NYN domain 332 451 1.2E-15 T 17-03-2017 IPR010298 Protein of unknown function DUF901 SHXM_RS29795 56903d7fac1c885b664abf5e6eea9441 271 TIGRFAM TIGR00091 TIGR00091: tRNA (guanine-N(7)-)-methyltransferase 96 268 1.3E-42 T 17-03-2017 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 Reactome: R-HSA-6782315 SHXM_RS29795 56903d7fac1c885b664abf5e6eea9441 271 Pfam PF02390 Putative methyltransferase 96 263 1.1E-47 T 17-03-2017 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 Reactome: R-HSA-6782315 SHXM_RS29795 56903d7fac1c885b664abf5e6eea9441 271 Hamap MF_01057 tRNA (guanine-N(7)-)-methyltransferase [trmB]. 48 269 27.796 T 17-03-2017 IPR003358 tRNA (guanine-N-7) methyltransferase, Trmb type GO:0006400|GO:0008176 Reactome: R-HSA-6782315 SHXM_RS29795 56903d7fac1c885b664abf5e6eea9441 271 Gene3D G3DSA:3.40.50.150 98 225 7.1E-9 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS29795 56903d7fac1c885b664abf5e6eea9441 271 SUPERFAMILY SSF53335 39 268 1.5E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44760 8cee2d4fdbaf8200d3be0dd7a8155d1d 456 SUPERFAMILY SSF103473 16 451 2.49E-85 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS44760 8cee2d4fdbaf8200d3be0dd7a8155d1d 456 Gene3D G3DSA:1.20.1250.20 31 223 3.2E-50 T 17-03-2017 SHXM_RS44760 8cee2d4fdbaf8200d3be0dd7a8155d1d 456 Gene3D G3DSA:1.20.1250.20 245 441 2.1E-25 T 17-03-2017 SHXM_RS44760 8cee2d4fdbaf8200d3be0dd7a8155d1d 456 Pfam PF07690 Major Facilitator Superfamily 41 408 3.1E-60 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS08680 c128db4fe4a803e67ae0692d90688a2f 411 TIGRFAM TIGR00619 sbcd: exonuclease SbcCD, D subunit 2 244 4.0E-53 T 17-03-2017 IPR004593 Nuclease SbcCD subunit D GO:0004519|GO:0006259|GO:0008408 SHXM_RS08680 c128db4fe4a803e67ae0692d90688a2f 411 Gene3D G3DSA:3.60.21.10 2 255 1.1E-70 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS08680 c128db4fe4a803e67ae0692d90688a2f 411 Pfam PF00149 Calcineurin-like phosphoesterase 2 95 3.2E-9 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS08680 c128db4fe4a803e67ae0692d90688a2f 411 Pfam PF12320 Type 5 capsule protein repressor C-terminal domain 268 355 7.7E-8 T 17-03-2017 IPR026843 Nuclease SbcCD subunit D, C-terminal domain SHXM_RS08680 c128db4fe4a803e67ae0692d90688a2f 411 SUPERFAMILY SSF56300 2 318 3.04E-52 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS26100 f95a8b7293704cd6e254fce3c585281a 173 SUPERFAMILY SSF64288 13 102 8.32E-18 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS26100 f95a8b7293704cd6e254fce3c585281a 173 Gene3D G3DSA:3.40.1410.10 11 103 5.4E-22 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS26100 f95a8b7293704cd6e254fce3c585281a 173 Pfam PF07702 UTRA domain 20 84 2.0E-11 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS04655 810687384a8866d18a4a1b721b1e3cca 536 Pfam PF13520 Amino acid permease 26 425 2.6E-37 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS17665 6b0987bcc902275b0ee617bc3094a96a 586 SUPERFAMILY SSF52016 389 574 5.96E-57 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS17665 6b0987bcc902275b0ee617bc3094a96a 586 Pfam PF00920 Dehydratase family 54 569 5.3E-172 T 17-03-2017 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS17665 6b0987bcc902275b0ee617bc3094a96a 586 SUPERFAMILY SSF143975 16 388 3.4E-122 T 17-03-2017 SHXM_RS17665 6b0987bcc902275b0ee617bc3094a96a 586 ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 137 147 - T 17-03-2017 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS17235 91df88025e968860c5a3ad3c96cf3d81 263 SMART SM00382 29 222 1.4E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17235 91df88025e968860c5a3ad3c96cf3d81 263 Pfam PF00005 ABC transporter 21 171 9.5E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17235 91df88025e968860c5a3ad3c96cf3d81 263 Gene3D G3DSA:3.40.50.300 6 234 3.2E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17235 91df88025e968860c5a3ad3c96cf3d81 263 SUPERFAMILY SSF52540 4 235 4.8E-49 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35920 70f631a2187481468f4a7a4574513906 225 Pfam PF13367 Protease prsW family 24 223 6.8E-11 T 17-03-2017 IPR026898 Protease PrsW GO:0008233 SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 SUPERFAMILY SSF53850 59 291 2.61E-42 T 17-03-2017 SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 TIGRFAM TIGR02995 ectoine_ehuB: ectoine/hydroxyectoine ABC transporter solute-binding protein EhuB 49 306 4.2E-82 T 17-03-2017 IPR014337 Ectoine/Hydroxyectoine-binding protein EhuB GO:0005886|GO:0033294|GO:0051470|GO:0051471 SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 Gene3D G3DSA:3.40.190.10 140 233 1.4E-7 T 17-03-2017 SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 Pfam PF00497 Bacterial extracellular solute-binding proteins, family 3 63 288 1.7E-41 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 Gene3D G3DSA:3.40.190.10 59 139 2.1E-25 T 17-03-2017 SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 Gene3D G3DSA:3.40.190.10 253 290 2.1E-25 T 17-03-2017 SHXM_RS22985 fcaf651f7d4b9a85c1a3125b632af730 307 SMART SM00062 62 294 2.4E-35 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS04790 73d079730ae0b30b64abbbd855a1d212 340 Gene3D G3DSA:3.40.50.720 3 143 8.3E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04790 73d079730ae0b30b64abbbd855a1d212 340 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 9 127 1.2E-27 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS04790 73d079730ae0b30b64abbbd855a1d212 340 SUPERFAMILY SSF55347 135 303 4.74E-25 T 17-03-2017 SHXM_RS04790 73d079730ae0b30b64abbbd855a1d212 340 Gene3D G3DSA:3.30.360.10 144 335 7.2E-47 T 17-03-2017 SHXM_RS04790 73d079730ae0b30b64abbbd855a1d212 340 SUPERFAMILY SSF51735 5 155 4.09E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 Pfam PF00375 Sodium:dicarboxylate symporter family 25 416 5.5E-100 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 ProSitePatterns PS00714 Sodium:dicarboxylate symporter family signature 2. 310 333 - T 17-03-2017 IPR018107 Sodium:dicarboxylate symporter, conserved site SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 ProSitePatterns PS00713 Sodium:dicarboxylate symporter family signature 1. 52 67 - T 17-03-2017 IPR018107 Sodium:dicarboxylate symporter, conserved site SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 SUPERFAMILY SSF118215 25 417 7.19E-107 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 PRINTS PR00173 Glutamate-aspartate symporter signature 307 333 1.3E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 PRINTS PR00173 Glutamate-aspartate symporter signature 90 115 1.3E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 PRINTS PR00173 Glutamate-aspartate symporter signature 342 361 1.3E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 PRINTS PR00173 Glutamate-aspartate symporter signature 19 39 1.3E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 PRINTS PR00173 Glutamate-aspartate symporter signature 60 80 1.3E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 PRINTS PR00173 Glutamate-aspartate symporter signature 160 182 1.3E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS39760 ee3442357e88cdc8bb1dafc185451f0b 477 Gene3D G3DSA:1.10.3860.10 24 422 1.8E-107 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS17000 55b0df5c9938b216c10af7ea0592ed49 66 Pfam PF00741 Gas vesicle protein 15 53 2.3E-14 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 Gene3D G3DSA:3.50.50.60 266 306 1.2E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 Gene3D G3DSA:3.50.50.60 3 157 1.2E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 SUPERFAMILY SSF51905 3 167 9.27E-62 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 SUPERFAMILY SSF51905 255 367 9.27E-62 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 301 319 4.4E-45 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 4.4E-45 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 146 161 4.4E-45 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 268 283 4.4E-45 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 319 335 4.4E-45 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 283 299 4.4E-45 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 Gene3D G3DSA:3.30.9.10 316 334 6.9E-8 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 Gene3D G3DSA:3.30.9.10 158 261 6.9E-8 T 17-03-2017 SHXM_RS07380 7d6aebb8d7b42ceae2e13d2427811533 516 Pfam PF01494 FAD binding domain 3 333 5.1E-83 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 Pfam PF00271 Helicase conserved C-terminal domain 283 380 1.9E-23 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 SMART SM00487 65 265 3.3E-52 T 17-03-2017 IPR014001 Helicase superfamily 1/2, ATP-binding domain SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 SMART SM00490 299 380 5.5E-28 T 17-03-2017 IPR001650 Helicase, C-terminal SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 SUPERFAMILY SSF52540 117 397 7.28E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 Gene3D G3DSA:3.40.50.300 255 406 7.0E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 Gene3D G3DSA:3.40.50.300 41 254 8.7E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22575 333962b7c5f7e91a34ea0be879c2b920 463 Pfam PF00270 DEAD/DEAH box helicase 70 239 5.9E-46 T 17-03-2017 IPR011545 DEAD/DEAH box helicase domain GO:0003676|GO:0005524 SHXM_RS40290 4404c83a77ae0c7ad46b41d71b086115 274 SMART SM00530 9 81 3.9E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS40290 4404c83a77ae0c7ad46b41d71b086115 274 SUPERFAMILY SSF47413 29 80 2.34E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40290 4404c83a77ae0c7ad46b41d71b086115 274 Pfam PF13560 Helix-turn-helix domain 6 84 6.6E-16 T 17-03-2017 SHXM_RS40290 4404c83a77ae0c7ad46b41d71b086115 274 Gene3D G3DSA:1.10.260.40 6 80 1.7E-18 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33425 16448d733f9a2d37297bc1b3ef972ae0 280 Pfam PF13365 Trypsin-like peptidase domain 50 218 1.4E-12 T 17-03-2017 SHXM_RS33425 16448d733f9a2d37297bc1b3ef972ae0 280 SUPERFAMILY SSF50494 31 238 2.4E-15 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS33425 16448d733f9a2d37297bc1b3ef972ae0 280 Gene3D G3DSA:2.40.10.10 136 226 1.1E-6 T 17-03-2017 SHXM_RS05485 f4c26d1c6b1c156a5062280d45b0f6fe 124 Gene3D G3DSA:1.10.10.10 8 115 2.2E-39 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05485 f4c26d1c6b1c156a5062280d45b0f6fe 124 Pfam PF01638 HxlR-like helix-turn-helix 28 115 7.6E-23 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS05485 f4c26d1c6b1c156a5062280d45b0f6fe 124 SUPERFAMILY SSF46785 14 115 1.95E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20395 4e72f6a246fc78e6d2381d507efafa00 397 Gene3D G3DSA:2.70.98.10 52 396 1.7E-136 T 17-03-2017 IPR014718 Glycoside hydrolase-type carbohydrate-binding GO:0003824|GO:0005975|GO:0030246 SHXM_RS20395 4e72f6a246fc78e6d2381d507efafa00 397 SUPERFAMILY SSF74650 51 395 1.13E-118 T 17-03-2017 IPR011013 Galactose mutarotase-like domain GO:0003824|GO:0005975|GO:0030246 SHXM_RS20395 4e72f6a246fc78e6d2381d507efafa00 397 PIRSF PIRSF005096 47 397 4.7E-133 T 17-03-2017 IPR015443 Aldose 1-epimerase GO:0016853|GO:0019318 KEGG: 00010+5.1.3.3|KEGG: 00052+5.1.3.3|MetaCyc: PWY-6317 SHXM_RS20395 4e72f6a246fc78e6d2381d507efafa00 397 Pfam PF01263 Aldose 1-epimerase 63 391 8.3E-97 T 17-03-2017 IPR008183 Aldose 1-/Glucose-6-phosphate 1-epimerase GO:0005975|GO:0016853 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 SUPERFAMILY SSF53067 128 261 7.45E-37 T 17-03-2017 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 TIGRFAM TIGR00671 baf: pantothenate kinase, type III 2 258 2.5E-77 T 17-03-2017 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 Hamap MF_01274 Type III pantothenate kinase [coaX]. 1 262 35.902 T 17-03-2017 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 Gene3D G3DSA:3.30.420.40 99 263 2.4E-51 T 17-03-2017 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 Pfam PF03309 Type III pantothenate kinase 2 211 2.3E-70 T 17-03-2017 IPR004619 Type III pantothenate kinase GO:0004594 KEGG: 00770+2.7.1.33|MetaCyc: PWY-3961 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 Gene3D G3DSA:3.30.420.40 1 68 3.7E-4 T 17-03-2017 SHXM_RS26320 5e2790ce5c7cd04f9903349d868b8951 265 SUPERFAMILY SSF53067 1 126 1.56E-32 T 17-03-2017 SHXM_RS46975 225d36ef2ec91722f696267934c084c6 427 Gene3D G3DSA:3.40.190.10 39 183 1.3E-13 T 17-03-2017 SHXM_RS46975 225d36ef2ec91722f696267934c084c6 427 Pfam PF13416 Bacterial extracellular solute-binding protein 51 351 4.8E-18 T 17-03-2017 SHXM_RS46975 225d36ef2ec91722f696267934c084c6 427 Gene3D G3DSA:3.40.190.10 184 332 4.8E-14 T 17-03-2017 SHXM_RS46975 225d36ef2ec91722f696267934c084c6 427 SUPERFAMILY SSF53850 39 420 1.69E-41 T 17-03-2017 SHXM_RS13515 267bb39697504e11d1aef142aca340b1 298 SUPERFAMILY SSF53474 17 292 5.45E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13515 267bb39697504e11d1aef142aca340b1 298 Pfam PF12697 Alpha/beta hydrolase family 23 291 9.9E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13515 267bb39697504e11d1aef142aca340b1 298 Gene3D G3DSA:3.40.50.1820 20 292 3.0E-44 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40570 387e877e38cd9510990cecc05a64e28b 140 Gene3D G3DSA:3.10.129.10 1 132 3.6E-33 T 17-03-2017 IPR029069 HotDog domain SHXM_RS40570 387e877e38cd9510990cecc05a64e28b 140 Pfam PF13279 Thioesterase-like superfamily 14 119 1.1E-15 T 17-03-2017 SHXM_RS40570 387e877e38cd9510990cecc05a64e28b 140 SUPERFAMILY SSF54637 3 133 6.71E-34 T 17-03-2017 IPR029069 HotDog domain SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 SUPERFAMILY SSF46785 18 79 2.82E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 ProSitePatterns PS01125 ROK family signature. 219 246 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 Pfam PF00480 ROK family 88 381 2.9E-51 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 Gene3D G3DSA:3.30.420.40 224 359 1.5E-41 T 17-03-2017 SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 Gene3D G3DSA:1.10.10.10 18 80 1.2E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 SUPERFAMILY SSF53067 86 384 5.94E-50 T 17-03-2017 SHXM_RS46425 89eb898373b7e131448fc62c8e9e1fef 403 Gene3D G3DSA:3.30.420.40 84 223 2.9E-36 T 17-03-2017 SHXM_RS33655 905aaf231fb3e0e58d61cb0575fe724a 196 Pfam PF00881 Nitroreductase family 15 174 5.7E-19 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS33655 905aaf231fb3e0e58d61cb0575fe724a 196 SUPERFAMILY SSF55469 14 194 8.11E-42 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS33655 905aaf231fb3e0e58d61cb0575fe724a 196 Gene3D G3DSA:3.40.109.10 13 194 2.1E-41 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS48465 5307b07ea0f8993a328f4a42fd162608 350 PIRSF PIRSF015921 8 350 6.8E-70 T 17-03-2017 IPR012171 Fatty acid desaturase GO:0006629|GO:0016021|GO:0016491 SHXM_RS48465 5307b07ea0f8993a328f4a42fd162608 350 Pfam PF00487 Fatty acid desaturase 68 326 1.5E-37 T 17-03-2017 IPR005804 Fatty acid desaturase domain GO:0006629 SHXM_RS38405 b53b01f41df445bba5df9b84d8412528 166 Gene3D G3DSA:3.10.129.10 19 147 2.3E-25 T 17-03-2017 IPR029069 HotDog domain SHXM_RS38405 b53b01f41df445bba5df9b84d8412528 166 Pfam PF03061 Thioesterase superfamily 58 128 8.4E-9 T 17-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 SHXM_RS38405 b53b01f41df445bba5df9b84d8412528 166 SUPERFAMILY SSF54637 20 135 1.2E-24 T 17-03-2017 IPR029069 HotDog domain SHXM_RS21165 53f5cb38f4919129d84ac1f55c6d7d04 242 SUPERFAMILY SSF81923 164 235 1.57E-9 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS21165 53f5cb38f4919129d84ac1f55c6d7d04 242 Gene3D G3DSA:1.10.1780.10 1 45 1.6E-44 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS21165 53f5cb38f4919129d84ac1f55c6d7d04 242 Gene3D G3DSA:1.10.1780.10 118 237 1.6E-44 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS21165 53f5cb38f4919129d84ac1f55c6d7d04 242 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 191 235 1.3E-7 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS08480 ec6f7cfee9dff8a6503d9b74c8e8c1bf 317 SUPERFAMILY SSF53187 56 316 1.89E-67 T 17-03-2017 SHXM_RS08480 ec6f7cfee9dff8a6503d9b74c8e8c1bf 317 Gene3D G3DSA:3.40.630.10 43 316 9.2E-76 T 17-03-2017 SHXM_RS08480 ec6f7cfee9dff8a6503d9b74c8e8c1bf 317 Pfam PF04389 Peptidase family M28 106 310 1.3E-46 T 17-03-2017 IPR007484 Peptidase M28 SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 Gene3D G3DSA:1.10.10.10 7 139 1.4E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 SUPERFAMILY SSF46785 9 137 1.38E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 Pfam PF12802 MarR family 31 86 5.2E-10 T 17-03-2017 SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 SUPERFAMILY SSF55729 143 289 2.7E-25 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 Gene3D G3DSA:3.40.630.30 144 301 1.7E-33 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 Pfam PF00583 Acetyltransferase (GNAT) family 201 279 3.5E-9 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS22445 cddcbe199af3342eac4f1a4571cf9307 305 SMART SM00347 23 123 8.8E-5 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 241 1.4E-58 T 17-03-2017 SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 150 169 7.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 79 90 7.2E-5 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 7 174 3.1E-4 T 17-03-2017 SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 205 225 3.4E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 3.4E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.4E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 3.4E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 3.4E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 3.4E-36 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 137 165 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 Gene3D G3DSA:3.40.50.720 4 242 5.1E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24005 a9ff7651528d3e46284152647d2b5fd3 244 SUPERFAMILY SSF51735 5 241 1.99E-74 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12060 e793b803ff7f24e8a2344e0fd09b15ad 489 PIRSF PIRSF002741 15 485 1.7E-81 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS12060 e793b803ff7f24e8a2344e0fd09b15ad 489 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 57 410 6.9E-79 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS12060 e793b803ff7f24e8a2344e0fd09b15ad 489 Gene3D G3DSA:3.10.105.10 261 458 2.6E-51 T 17-03-2017 SHXM_RS12060 e793b803ff7f24e8a2344e0fd09b15ad 489 Gene3D G3DSA:3.40.190.10 114 260 3.1E-33 T 17-03-2017 SHXM_RS12060 e793b803ff7f24e8a2344e0fd09b15ad 489 SUPERFAMILY SSF53850 44 478 1.16E-107 T 17-03-2017 SHXM_RS34800 cc52834184223b55b27886836a538b17 314 Pfam PF01370 NAD dependent epimerase/dehydratase family 6 226 5.8E-19 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS34800 cc52834184223b55b27886836a538b17 314 SUPERFAMILY SSF51735 2 300 2.01E-44 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS34800 cc52834184223b55b27886836a538b17 314 Gene3D G3DSA:3.40.50.720 4 297 1.2E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47050 078a136b724f917cf61816ccb51cd3e3 291 Pfam PF04909 Amidohydrolase 9 288 2.1E-57 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS47050 078a136b724f917cf61816ccb51cd3e3 291 SUPERFAMILY SSF51556 9 288 6.08E-64 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS47050 078a136b724f917cf61816ccb51cd3e3 291 Gene3D G3DSA:3.20.20.140 9 289 4.3E-63 T 17-03-2017 SHXM_RS08885 97c5dab253b56fe2b4dec9088ae0e4d2 406 Gene3D G3DSA:1.20.1250.20 26 208 1.3E-9 T 17-03-2017 SHXM_RS08885 97c5dab253b56fe2b4dec9088ae0e4d2 406 Pfam PF07690 Major Facilitator Superfamily 31 245 2.1E-11 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS08885 97c5dab253b56fe2b4dec9088ae0e4d2 406 Gene3D G3DSA:1.20.1250.20 227 404 2.5E-11 T 17-03-2017 SHXM_RS08885 97c5dab253b56fe2b4dec9088ae0e4d2 406 SUPERFAMILY SSF103473 27 403 2.22E-33 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS37100 1db9127b9bb3173b3bc538c19035193f 246 SUPERFAMILY SSF69796 12 239 3.01E-52 T 17-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS37100 1db9127b9bb3173b3bc538c19035193f 246 Pfam PF02511 Thymidylate synthase complementing protein 20 232 4.6E-49 T 17-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS37100 1db9127b9bb3173b3bc538c19035193f 246 TIGRFAM TIGR02170 thyX: thymidylate synthase, flavin-dependent 19 238 3.8E-61 T 17-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS37100 1db9127b9bb3173b3bc538c19035193f 246 Hamap MF_01408 Thymidylate synthase ThyX [thyX]. 15 246 27.679 T 17-03-2017 IPR003669 Thymidylate synthase ThyX GO:0006231|GO:0050660|GO:0050797 KEGG: 00240+2.1.1.148|KEGG: 00270+2.1.1.14|KEGG: 00450+2.1.1.14|KEGG: 00670+2.1.1.148|MetaCyc: PWY-5041|MetaCyc: PWY-6151|MetaCyc: PWY-6545|MetaCyc: PWY-6936|MetaCyc: PWY-702 SHXM_RS24890 0cba69f8b75639fe746135d3901f297a 238 SUPERFAMILY SSF53597 17 233 2.94E-53 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS24890 0cba69f8b75639fe746135d3901f297a 238 Pfam PF01872 RibD C-terminal domain 19 230 2.1E-52 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS24890 0cba69f8b75639fe746135d3901f297a 238 TIGRFAM TIGR00227 ribD_Cterm: riboflavin-specific deaminase C-terminal domain 18 235 1.7E-56 T 17-03-2017 IPR011549 Riboflavin-specific deaminase, C-terminal GO:0008703|GO:0009231|GO:0050661|GO:0055114 SHXM_RS24890 0cba69f8b75639fe746135d3901f297a 238 Gene3D G3DSA:3.40.430.10 15 234 1.4E-61 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS26395 dabbc21c9de89bf237aef120194e18a6 245 SUPERFAMILY SSF161098 21 205 1.01E-33 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26395 dabbc21c9de89bf237aef120194e18a6 245 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 46 208 6.3E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26395 dabbc21c9de89bf237aef120194e18a6 245 Gene3D G3DSA:1.10.3720.10 18 204 3.6E-25 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23500 0f08a4d78575a6bfe72e229121c7a26d 321 TIGRFAM TIGR04187 GRASP_SAV_5884: ATP-grasp ribosomal peptide maturase, SAV_5884 family 3 317 2.8E-120 T 17-03-2017 IPR026449 ATP-grasp ribosomal peptide maturase, SAV_5884 family SHXM_RS23500 0f08a4d78575a6bfe72e229121c7a26d 321 SUPERFAMILY SSF56059 136 317 2.75E-19 T 17-03-2017 SHXM_RS03730 dd6a5930ea7e6bcdf2f4a913dbe7ac31 301 SUPERFAMILY SSF81296 31 211 2.66E-40 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS03730 dd6a5930ea7e6bcdf2f4a913dbe7ac31 301 Gene3D G3DSA:2.70.50.50 31 211 5.4E-44 T 17-03-2017 SHXM_RS03730 dd6a5930ea7e6bcdf2f4a913dbe7ac31 301 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 31 208 3.3E-36 T 17-03-2017 IPR004302 Chitin-binding protein, N-terminal SHXM_RS50925 6a266159174af356598a2382548a77be 553 Pfam PF09299 Mu transposase, C-terminal 372 425 1.0E-9 T 17-03-2017 IPR015378 Transposase-like, Mu, C-terminal SHXM_RS50925 6a266159174af356598a2382548a77be 553 Pfam PF13384 Homeodomain-like domain 25 64 3.8E-6 T 17-03-2017 SHXM_RS50925 6a266159174af356598a2382548a77be 553 Gene3D G3DSA:2.30.30.130 368 429 1.4E-7 T 17-03-2017 IPR009004 Transposase, Mu, C-terminal SHXM_RS50925 6a266159174af356598a2382548a77be 553 Pfam PF00665 Integrase core domain 165 288 9.0E-12 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS50925 6a266159174af356598a2382548a77be 553 SUPERFAMILY SSF53098 163 347 7.74E-17 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50925 6a266159174af356598a2382548a77be 553 Gene3D G3DSA:3.30.420.10 165 352 2.5E-22 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS26525 3d4590b096e44363c1d547c872ff1d9b 485 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 252 259 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS26525 3d4590b096e44363c1d547c872ff1d9b 485 Gene3D G3DSA:3.40.309.10 267 449 1.2E-64 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS26525 3d4590b096e44363c1d547c872ff1d9b 485 Gene3D G3DSA:3.40.605.10 11 266 1.7E-77 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS26525 3d4590b096e44363c1d547c872ff1d9b 485 Pfam PF00171 Aldehyde dehydrogenase family 25 474 5.1E-154 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS26525 3d4590b096e44363c1d547c872ff1d9b 485 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 280 291 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS26525 3d4590b096e44363c1d547c872ff1d9b 485 SUPERFAMILY SSF53720 10 479 1.7E-150 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS37030 7d9a6e79033a520fb719515cb6cc9c4b 148 Pfam PF10824 Excreted virulence factor EspC, type VII ESX diderm 39 134 7.1E-7 T 17-03-2017 IPR022536 ESX-1 secretion-associated protein EspC SHXM_RS37030 7d9a6e79033a520fb719515cb6cc9c4b 148 Gene3D G3DSA:1.10.287.1060 40 128 2.3E-4 T 17-03-2017 SHXM_RS40505 42f6c13bc7e0574e9a714e1ec1cd4bfc 400 Pfam PF13556 PucR C-terminal helix-turn-helix domain 331 389 6.8E-17 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 11 24 5.3E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 32 55 5.3E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 SUPERFAMILY SSF46689 4 83 1.03E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 Pfam PF00440 Bacterial regulatory proteins, tetR family 11 57 6.6E-16 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 Gene3D G3DSA:1.10.357.10 3 194 6.1E-41 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 Pfam PF16925 Bacterial transcriptional repressor C-terminal 79 193 1.6E-13 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41115 49d9f3603a133cc967eb80d17c37839b 206 SUPERFAMILY SSF48498 78 194 4.97E-19 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS17670 2029720a61f59862d0c59b0df0bfd925 300 SUPERFAMILY SSF51569 13 298 2.93E-65 T 17-03-2017 SHXM_RS17670 2029720a61f59862d0c59b0df0bfd925 300 PIRSF PIRSF001365 7 299 1.9E-64 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS17670 2029720a61f59862d0c59b0df0bfd925 300 Gene3D G3DSA:3.20.20.70 8 298 1.1E-76 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS17670 2029720a61f59862d0c59b0df0bfd925 300 SMART SM01130 9 299 1.9E-62 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS17670 2029720a61f59862d0c59b0df0bfd925 300 Pfam PF00701 Dihydrodipicolinate synthetase family 11 296 3.0E-47 T 17-03-2017 IPR002220 DapA-like GO:0008152|GO:0016829 SHXM_RS24960 51fb2400c035136a198d27358443500f 400 Pfam PF01757 Acyltransferase family 54 381 5.9E-21 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS42780 7c0adeb32fa86fa5b005f34c435fe080 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 20 33 7.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42780 7c0adeb32fa86fa5b005f34c435fe080 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 41 64 7.4E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42780 7c0adeb32fa86fa5b005f34c435fe080 213 Gene3D G3DSA:1.10.357.10 14 186 2.3E-28 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS42780 7c0adeb32fa86fa5b005f34c435fe080 213 ProSitePatterns PS01081 TetR-type HTH domain signature. 32 63 - T 17-03-2017 IPR023772 DNA-binding HTH domain, TetR-type, conserved site SHXM_RS42780 7c0adeb32fa86fa5b005f34c435fe080 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 20 64 1.0E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS42780 7c0adeb32fa86fa5b005f34c435fe080 213 SUPERFAMILY SSF46689 12 78 5.03E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS35420 fd104eca2c65c40053cc75aa95a8fd88 228 Pfam PF01730 UreF 40 184 1.2E-22 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS35420 fd104eca2c65c40053cc75aa95a8fd88 228 Hamap MF_01385 Urease accessory protein UreF [ureF]. 5 228 21.152 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS35420 fd104eca2c65c40053cc75aa95a8fd88 228 PIRSF PIRSF009467 3 228 4.6E-45 T 17-03-2017 IPR002639 Urease accessory protein UreF GO:0006807|GO:0016151 SHXM_RS42015 7b7df162b96fabd1d009b7cfc77c22a7 150 Pfam PF01757 Acyltransferase family 46 140 1.1E-12 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 Pfam PF07398 MDMPI C-terminal domain 172 264 1.0E-8 T 17-03-2017 IPR010872 MDMPI C-terminal SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 17 153 4.7E-20 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 Gene3D G3DSA:3.30.1050.10 184 264 1.8E-4 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 SUPERFAMILY SSF55718 195 270 5.18E-5 T 17-03-2017 IPR003033 SCP2 sterol-binding domain SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 14 244 1.0E-35 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 SUPERFAMILY SSF109854 4 158 3.2E-32 T 17-03-2017 SHXM_RS28460 2f25c966de2cf20b154871e509de4783 274 Gene3D G3DSA:1.20.120.450 6 157 6.0E-9 T 17-03-2017 IPR027369 DinB/YfiT-like putative metal-dependent hydrolase SHXM_RS35110 0df12f0edb1452814bef569b4c2436c0 509 Gene3D G3DSA:3.40.50.1390 3 113 1.8E-4 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS35110 0df12f0edb1452814bef569b4c2436c0 509 Pfam PF07508 Recombinase 173 283 1.6E-15 T 17-03-2017 IPR011109 DNA-binding recombinase domain GO:0000150|GO:0003677 SHXM_RS13210 444d3b66b58fd511e73e0848b2495fef 498 TIGRFAM TIGR00908 2A0305: ethanolamine permease 37 484 2.1E-145 T 17-03-2017 IPR004757 Ethanolamine permease SHXM_RS13210 444d3b66b58fd511e73e0848b2495fef 498 PIRSF PIRSF006060 31 495 4.3E-65 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS13210 444d3b66b58fd511e73e0848b2495fef 498 Pfam PF13520 Amino acid permease 55 455 2.8E-41 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS02515 0c2ea378c3f2899e3f5ac1bcca89868c 242 Pfam PF06197 Protein of unknown function (DUF998) 26 215 1.6E-16 T 17-03-2017 IPR009339 Protein of unknown function DUF998 SHXM_RS46095 772151a2b1b996a8cc7b6b0b7fb114db 414 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 214 399 2.2E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS46095 772151a2b1b996a8cc7b6b0b7fb114db 414 SUPERFAMILY SSF52266 210 406 3.21E-46 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS46095 772151a2b1b996a8cc7b6b0b7fb114db 414 Gene3D G3DSA:3.40.50.1110 212 405 1.0E-33 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS28560 9cf1514a973a580ffadac4a6378e4455 345 SUPERFAMILY SSF46785 2 100 3.48E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28560 9cf1514a973a580ffadac4a6378e4455 345 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 2 65 3.3E-7 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS28560 9cf1514a973a580ffadac4a6378e4455 345 Gene3D G3DSA:1.10.10.10 2 87 8.9E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 Gene3D G3DSA:3.20.20.70 196 264 2.6E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 Gene3D G3DSA:3.20.20.70 58 162 2.6E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 SUPERFAMILY SSF51366 17 287 1.18E-21 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 Pfam PF03437 BtpA family 28 287 2.5E-64 T 17-03-2017 IPR005137 Photosystem I BtpA, assembly SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 ProDom PD011184 BTPA I PHOTOSYSTEM BIOGENESIS ASSEMBLY SGCQ TRIPHOSPHATASE NUCLEOSIDE PAE3553 ENZYME 50 233 5.0E-50 T 17-03-2017 IPR005137 Photosystem I BtpA, assembly SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 TIGRFAM TIGR00259 thylakoid_BtpA: membrane complex biogenesis protein, BtpA family 28 288 9.3E-58 T 17-03-2017 IPR005137 Photosystem I BtpA, assembly SHXM_RS48535 5de2502aeb1a76dac61c286d0ceb8c2f 294 PIRSF PIRSF005956 18 291 9.5E-86 T 17-03-2017 IPR005137 Photosystem I BtpA, assembly SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 SMART SM01192 10 279 8.7E-165 T 17-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 SUPERFAMILY SSF51604 17 276 3.4E-104 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 PRINTS PR00148 Enolase signature 188 202 3.3E-22 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 PRINTS PR00148 Enolase signature 165 176 3.3E-22 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 PRINTS PR00148 Enolase signature 217 234 3.3E-22 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 PRINTS PR00148 Enolase signature 15 28 3.3E-22 T 17-03-2017 IPR000941 Enolase GO:0000015|GO:0000287|GO:0004634|GO:0006096 KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 ProSitePatterns PS00164 Enolase signature. 188 201 - T 17-03-2017 IPR020809 Enolase, conserved site KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218|Reactome: R-HSA-70171|Reactome: R-HSA-70263 SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 Gene3D G3DSA:3.20.20.120 18 277 3.9E-105 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS47370 76ae55db92e19af861e087f7d5dc03a7 285 Pfam PF00113 Enolase, C-terminal TIM barrel domain 18 276 8.5E-105 T 17-03-2017 IPR020810 Enolase, C-terminal TIM barrel domain KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS34890 ce9b4506e6878d1360d76f2b91f1c214 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 57 5.5E-15 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34890 ce9b4506e6878d1360d76f2b91f1c214 192 SUPERFAMILY SSF46689 5 78 4.51E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS34890 ce9b4506e6878d1360d76f2b91f1c214 192 SUPERFAMILY SSF48498 80 184 5.44E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS34890 ce9b4506e6878d1360d76f2b91f1c214 192 Gene3D G3DSA:1.10.357.10 10 188 4.5E-33 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34890 ce9b4506e6878d1360d76f2b91f1c214 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34890 ce9b4506e6878d1360d76f2b91f1c214 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 5.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 TIGRFAM TIGR01727 oligo_HPY: oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain 272 363 4.0E-22 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 Pfam PF00005 ABC transporter 59 221 1.2E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 SUPERFAMILY SSF52540 39 292 1.66E-68 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 Gene3D G3DSA:3.40.50.300 38 294 6.9E-75 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 Pfam PF08352 Oligopeptide/dipeptide transporter, C-terminal region 273 334 3.3E-19 T 17-03-2017 IPR013563 Oligopeptide/dipeptide ABC transporter, C-terminal GO:0000166|GO:0005524|GO:0015833 SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 SMART SM00382 67 271 3.5E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35995 adbf5f216abda56d10f7e125c2785f01 380 ProSitePatterns PS00211 ABC transporters family signature. 194 208 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS25545 069cb8d6930d79d2a7a858a1c573076d 395 Pfam PF01070 FMN-dependent dehydrogenase 46 394 2.4E-122 T 17-03-2017 IPR000262 FMN-dependent dehydrogenase GO:0016491 SHXM_RS25545 069cb8d6930d79d2a7a858a1c573076d 395 ProSitePatterns PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 292 298 - T 17-03-2017 IPR008259 FMN-dependent alpha-hydroxy acid dehydrogenase, active site GO:0016491|GO:0055114 SHXM_RS25545 069cb8d6930d79d2a7a858a1c573076d 395 SUPERFAMILY SSF51395 38 393 1.83E-90 T 17-03-2017 SHXM_RS25545 069cb8d6930d79d2a7a858a1c573076d 395 Gene3D G3DSA:3.20.20.70 37 394 1.5E-130 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS25545 069cb8d6930d79d2a7a858a1c573076d 395 PIRSF PIRSF000138 15 395 1.7E-120 T 17-03-2017 IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent GO:0010181|GO:0016491|GO:0055114 SHXM_RS26210 b073d1a286d0a50e9159e8a9287f0130 250 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS26210 b073d1a286d0a50e9159e8a9287f0130 250 PIRSF PIRSF039085 1 250 2.4E-119 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS26210 b073d1a286d0a50e9159e8a9287f0130 250 Pfam PF00005 ABC transporter 17 175 2.0E-35 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS26210 b073d1a286d0a50e9159e8a9287f0130 250 SUPERFAMILY SSF52540 2 245 1.39E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26210 b073d1a286d0a50e9159e8a9287f0130 250 Gene3D G3DSA:3.40.50.300 2 246 1.2E-83 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26210 b073d1a286d0a50e9159e8a9287f0130 250 SMART SM00382 26 212 8.6E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS14535 c4414b4d0e657db4e9744b8d2e52b9bd 85 Pfam PF00550 Phosphopantetheine attachment site 12 76 2.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS14535 c4414b4d0e657db4e9744b8d2e52b9bd 85 SUPERFAMILY SSF47336 9 83 2.49E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS14535 c4414b4d0e657db4e9744b8d2e52b9bd 85 ProSitePatterns PS00012 Phosphopantetheine attachment site. 37 52 - T 17-03-2017 IPR006162 Phosphopantetheine attachment site SHXM_RS14535 c4414b4d0e657db4e9744b8d2e52b9bd 85 Gene3D G3DSA:1.10.1200.10 9 82 1.4E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS23460 117005eb3f2468dce75a92dc71900a6e 168 Pfam PF06271 RDD family 21 159 3.2E-19 T 17-03-2017 IPR010432 RDD SHXM_RS31850 279bcb0622290d4005958b096d44bf10 375 SUPERFAMILY SSF51679 1 358 3.79E-65 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS31850 279bcb0622290d4005958b096d44bf10 375 Pfam PF00296 Luciferase-like monooxygenase 1 329 3.0E-42 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS31850 279bcb0622290d4005958b096d44bf10 375 Gene3D G3DSA:3.20.20.30 1 366 3.9E-74 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS20650 e7cbf9be10c83017c3fb2e9930354738 119 SUPERFAMILY SSF51182 20 103 4.18E-7 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS20650 e7cbf9be10c83017c3fb2e9930354738 119 Gene3D G3DSA:2.60.120.10 12 103 2.1E-10 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS43930 f8e4b6f6efc5ef45d383e421d669f4b6 262 Pfam PF05949 Bacterial protein of unknown function (DUF881) 125 257 9.3E-40 T 17-03-2017 IPR010273 Protein of unknown function DUF881 SHXM_RS12500 6abdc4b49c377b562d0755dfe06d440d 238 SUPERFAMILY SSF56281 6 223 7.85E-48 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS12500 6abdc4b49c377b562d0755dfe06d440d 238 Pfam PF00753 Metallo-beta-lactamase superfamily 9 202 1.0E-27 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS12500 6abdc4b49c377b562d0755dfe06d440d 238 Gene3D G3DSA:3.60.15.10 9 220 5.3E-50 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS12500 6abdc4b49c377b562d0755dfe06d440d 238 SMART SM00849 12 202 3.3E-38 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS06225 cde28bb89e4d5f11119d67fdb03c696f 76 SUPERFAMILY SSF52540 4 62 2.42E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS06225 cde28bb89e4d5f11119d67fdb03c696f 76 Gene3D G3DSA:3.40.50.300 3 61 1.0E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33360 101da09b178aa719538f6dc4a103a4d3 429 SMART SM01119 318 416 5.8E-34 T 17-03-2017 IPR026956 D-serine dehydratase-like domain SHXM_RS33360 101da09b178aa719538f6dc4a103a4d3 429 Pfam PF14031 Putative serine dehydratase domain 318 414 8.0E-16 T 17-03-2017 IPR026956 D-serine dehydratase-like domain SHXM_RS33360 101da09b178aa719538f6dc4a103a4d3 429 SUPERFAMILY SSF51419 59 274 7.19E-22 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS33360 101da09b178aa719538f6dc4a103a4d3 429 Gene3D G3DSA:3.20.20.10 145 268 4.0E-12 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS08190 c5641ded0ade7e38b8d4b87f8d2eb03c 310 Pfam PF03756 A-factor biosynthesis hotdog domain 30 167 1.4E-20 T 17-03-2017 IPR005509 A-factor biosynthesis hotdog domain SHXM_RS08190 c5641ded0ade7e38b8d4b87f8d2eb03c 310 Pfam PF03756 A-factor biosynthesis hotdog domain 216 256 1.5E-9 T 17-03-2017 IPR005509 A-factor biosynthesis hotdog domain SHXM_RS30430 df42333011ea907ae25d1b409dc91243 348 SMART SM00563 135 254 1.7E-15 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS30430 df42333011ea907ae25d1b409dc91243 348 Pfam PF01553 Acyltransferase 120 251 8.8E-17 T 17-03-2017 IPR002123 Phospholipid/glycerol acyltransferase GO:0008152|GO:0016746 SHXM_RS30430 df42333011ea907ae25d1b409dc91243 348 Gene3D G3DSA:3.40.1130.10 109 260 1.2E-4 T 17-03-2017 SHXM_RS30430 df42333011ea907ae25d1b409dc91243 348 SUPERFAMILY SSF69593 108 339 1.27E-33 T 17-03-2017 SHXM_RS27155 d619d6331f650ef1397709f911fcc55d 111 TIGRFAM TIGR00103 DNA_YbaB_EbfC: DNA-binding protein, YbaB/EbfC family 6 109 2.9E-25 T 17-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family SHXM_RS27155 d619d6331f650ef1397709f911fcc55d 111 SUPERFAMILY SSF82607 14 108 1.02E-27 T 17-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family SHXM_RS27155 d619d6331f650ef1397709f911fcc55d 111 Gene3D G3DSA:3.30.1310.10 5 109 3.4E-41 T 17-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family SHXM_RS27155 d619d6331f650ef1397709f911fcc55d 111 Pfam PF02575 YbaB/EbfC DNA-binding family 15 103 3.6E-32 T 17-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family SHXM_RS27155 d619d6331f650ef1397709f911fcc55d 111 PIRSF PIRSF004555 6 111 9.0E-35 T 17-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family SHXM_RS27155 d619d6331f650ef1397709f911fcc55d 111 Hamap MF_00274 Nucleoid-associated protein YbaB [ybaB]. 8 102 21.223 T 17-03-2017 IPR004401 Nucleoid-associated protein YbaB/EbfC family SHXM_RS16675 4758544f8a43612d762a3f740baf540b 765 SUPERFAMILY SSF82866 121 335 1.44E-31 T 17-03-2017 SHXM_RS16675 4758544f8a43612d762a3f740baf540b 765 Gene3D G3DSA:1.20.1640.10 141 340 5.2E-34 T 17-03-2017 SHXM_RS16675 4758544f8a43612d762a3f740baf540b 765 Gene3D G3DSA:1.20.1640.10 504 724 7.7E-31 T 17-03-2017 SHXM_RS16675 4758544f8a43612d762a3f740baf540b 765 SUPERFAMILY SSF82866 494 721 1.57E-26 T 17-03-2017 SHXM_RS16675 4758544f8a43612d762a3f740baf540b 765 Pfam PF03176 MMPL family 427 726 2.2E-37 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS16675 4758544f8a43612d762a3f740baf540b 765 Pfam PF03176 MMPL family 45 389 5.6E-77 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS28550 cd838edab10c580f543935b52249faf5 641 Gene3D G3DSA:3.40.50.410 442 557 3.0E-4 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS28550 cd838edab10c580f543935b52249faf5 641 SMART SM00327 439 608 3.6E-5 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS28550 cd838edab10c580f543935b52249faf5 641 Pfam PF10138 vWA found in TerF C terminus 440 638 4.5E-53 T 17-03-2017 IPR019303 vWA found in TerF C terminus SHXM_RS28550 cd838edab10c580f543935b52249faf5 641 SUPERFAMILY SSF53300 442 591 3.25E-11 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS05230 d3988dea6f274b63a16cd7c21419d401 249 Gene3D G3DSA:3.30.460.10 13 100 1.3E-10 T 17-03-2017 SHXM_RS05230 d3988dea6f274b63a16cd7c21419d401 249 Pfam PF01909 Nucleotidyltransferase domain 17 61 3.0E-6 T 17-03-2017 IPR002934 Polymerase, nucleotidyl transferase domain GO:0016779 SHXM_RS05230 d3988dea6f274b63a16cd7c21419d401 249 SUPERFAMILY SSF81301 8 58 6.87E-9 T 17-03-2017 SHXM_RS27860 ff43fcd641dc0150496bc2a6c51c137a 126 Pfam PF04020 Mycobacterial 4 TMS phage holin, superfamily IV 3 115 5.6E-29 T 17-03-2017 IPR007165 Mycobacterial 4 TMS phage holin, superfamily IV SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 Gene3D G3DSA:3.40.50.300 397 574 3.3E-35 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 Pfam PF00664 ABC transporter transmembrane region 32 301 1.1E-25 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 ProSitePatterns PS00211 ABC transporters family signature. 487 501 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 SUPERFAMILY SSF52540 376 573 1.37E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 SUPERFAMILY SSF90123 20 331 4.19E-54 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 Pfam PF00005 ABC transporter 404 515 9.9E-9 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS08260 30b4a8441a04e9a70f480135d1c65459 587 Gene3D G3DSA:1.20.1560.10 21 330 1.5E-51 T 17-03-2017 SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 ProSitePatterns PS00059 Zinc-containing alcohol dehydrogenases signature. 59 73 - T 17-03-2017 IPR002328 Alcohol dehydrogenase, zinc-type, conserved site GO:0008270|GO:0016491|GO:0055114 Reactome: R-HSA-71384 SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 Pfam PF00107 Zinc-binding dehydrogenase 178 293 2.8E-23 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 128 5.7E-28 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 SUPERFAMILY SSF51735 143 308 7.46E-38 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 SUPERFAMILY SSF50129 1 166 5.93E-52 T 17-03-2017 IPR011032 GroES-like SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 Gene3D G3DSA:3.40.50.720 173 287 9.4E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 Gene3D G3DSA:3.90.180.10 1 172 1.8E-51 T 17-03-2017 IPR011032 GroES-like SHXM_RS08005 6d8455e3b6c9fd301a78265392e0bb09 355 SMART SM00829 8 343 0.0018 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00412 Epoxide hydrolase signature 80 93 3.9E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00412 Epoxide hydrolase signature 38 53 3.9E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00412 Epoxide hydrolase signature 18 36 3.9E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00412 Epoxide hydrolase signature 94 107 3.9E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00412 Epoxide hydrolase signature 229 251 3.9E-10 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 SUPERFAMILY SSF53474 6 253 5.63E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 Gene3D G3DSA:3.40.50.1820 6 253 3.8E-41 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 38 53 3.5E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 94 107 3.5E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 PRINTS PR00111 Alpha/beta hydrolase fold signature 80 93 3.5E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS13855 a3e3ee49166d05c24a0c3f5006aa8352 256 Pfam PF12697 Alpha/beta hydrolase family 14 246 5.2E-19 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS38715 9c98db659f202bc146257e2e116e5229 267 Gene3D G3DSA:3.40.50.300 20 233 2.6E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38715 9c98db659f202bc146257e2e116e5229 267 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS38715 9c98db659f202bc146257e2e116e5229 267 SMART SM00382 51 225 6.9E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS38715 9c98db659f202bc146257e2e116e5229 267 Pfam PF00005 ABC transporter 42 175 1.9E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS38715 9c98db659f202bc146257e2e116e5229 267 SUPERFAMILY SSF52540 23 242 4.33E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS23815 542c3ce0247c9b2ecbdf44acde8ab476 483 Pfam PF13560 Helix-turn-helix domain 76 119 1.2E-7 T 17-03-2017 SHXM_RS23815 542c3ce0247c9b2ecbdf44acde8ab476 483 SUPERFAMILY SSF47413 76 122 1.18E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS23815 542c3ce0247c9b2ecbdf44acde8ab476 483 Gene3D G3DSA:1.10.260.40 76 123 1.2E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS18120 c05b0fc6468d249464e40a08abe5ef25 333 Pfam PF11271 Protein of unknown function (DUF3068) 5 305 3.9E-80 T 17-03-2017 IPR021424 Protein of unknown function DUF3068 SHXM_RS11350 ef8f01b02d761efaf585768c5cce0abf 119 Pfam PF00582 Universal stress protein family 65 116 5.8E-9 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS11350 ef8f01b02d761efaf585768c5cce0abf 119 SUPERFAMILY SSF52402 3 118 4.94E-13 T 17-03-2017 SHXM_RS11350 ef8f01b02d761efaf585768c5cce0abf 119 PRINTS PR01438 Universal stress protein signature 94 116 2.3E-5 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS11350 ef8f01b02d761efaf585768c5cce0abf 119 PRINTS PR01438 Universal stress protein signature 76 88 2.3E-5 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS11350 ef8f01b02d761efaf585768c5cce0abf 119 Gene3D G3DSA:3.40.50.620 61 116 6.8E-12 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS25840 4fc9017c086c31272bfc7f95119550c5 323 ProSitePatterns PS01272 Glucokinase regulatory protein family signature. 208 225 - T 17-03-2017 IPR005486 Glucokinase regulatory protein, conserved site KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126|Reactome: R-HSA-170822|Reactome: R-HSA-5619107 SHXM_RS25840 4fc9017c086c31272bfc7f95119550c5 323 Hamap MF_00068 N-acetylmuramic acid 6-phosphate etherase [murQ]. 25 318 41.109 T 17-03-2017 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126 SHXM_RS25840 4fc9017c086c31272bfc7f95119550c5 323 SUPERFAMILY SSF53697 29 270 1.76E-64 T 17-03-2017 SHXM_RS25840 4fc9017c086c31272bfc7f95119550c5 323 TIGRFAM TIGR00274 TIGR00274: N-acetylmuramic acid 6-phosphate etherase 29 319 1.6E-111 T 17-03-2017 IPR005488 N-acetylmuramic acid 6-phosphate etherase MurQ GO:0016835|GO:0046348 KEGG: 00030+4.2.1.12|KEGG: 00520+4.2.1.126 SHXM_RS25840 4fc9017c086c31272bfc7f95119550c5 323 Pfam PF01380 SIS domain 149 230 2.7E-9 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS25840 4fc9017c086c31272bfc7f95119550c5 323 Gene3D G3DSA:3.40.50.10490 26 272 1.4E-79 T 17-03-2017 SHXM_RS17450 7831cae773c73f727521f583c51338db 172 Pfam PF03780 Asp23 family, cell envelope-related function 49 158 1.6E-30 T 17-03-2017 IPR005531 Alkaline shock protein Asp23 SHXM_RS41460 151e5afa5bd3a0b165d076766b50a9db 66 SUPERFAMILY SSF54862 2 63 1.79E-15 T 17-03-2017 SHXM_RS41460 151e5afa5bd3a0b165d076766b50a9db 66 PRINTS PR00352 3Fe-4S ferredoxin signature 16 26 1.9E-7 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS41460 151e5afa5bd3a0b165d076766b50a9db 66 PRINTS PR00352 3Fe-4S ferredoxin signature 48 60 1.9E-7 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS41460 151e5afa5bd3a0b165d076766b50a9db 66 PRINTS PR00352 3Fe-4S ferredoxin signature 5 16 1.9E-7 T 17-03-2017 IPR001080 3Fe-4S ferredoxin GO:0005506|GO:0009055 SHXM_RS41460 151e5afa5bd3a0b165d076766b50a9db 66 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 5 62 2.2E-12 T 17-03-2017 SHXM_RS41460 151e5afa5bd3a0b165d076766b50a9db 66 Gene3D G3DSA:3.30.70.20 1 64 1.0E-16 T 17-03-2017 SHXM_RS13005 e79f9011242e81a77303897323aa2f8c 266 Gene3D G3DSA:3.40.50.1110 10 195 9.5E-34 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13005 e79f9011242e81a77303897323aa2f8c 266 SUPERFAMILY SSF52266 9 195 1.15E-34 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13005 e79f9011242e81a77303897323aa2f8c 266 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 13 186 9.0E-24 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS02900 ac10f2107af09997524f97d1a7911b77 403 Pfam PF01594 Domain of unknown function DUF20 74 395 2.1E-50 T 17-03-2017 IPR002549 Transmembrane protein TqsA-like SHXM_RS40635 ac115739c20c30c4fa0b77fc27b769da 505 Pfam PF13520 Amino acid permease 41 442 5.0E-57 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS40635 ac115739c20c30c4fa0b77fc27b769da 505 PIRSF PIRSF006060 18 486 2.2E-86 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 192 233 1.7E-10 T 17-03-2017 IPR001434 Domain of unknown function DUF11 SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 TIGRFAM TIGR01451 B_ant_repeat: conserved repeat domain 343 388 4.5E-17 T 17-03-2017 IPR001434 Domain of unknown function DUF11 SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 Pfam PF01345 Domain of unknown function DUF11 318 388 2.4E-16 T 17-03-2017 IPR001434 Domain of unknown function DUF11 SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 Pfam PF01345 Domain of unknown function DUF11 188 230 1.8E-7 T 17-03-2017 IPR001434 Domain of unknown function DUF11 SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 SUPERFAMILY SSF49401 193 314 1.99E-6 T 17-03-2017 IPR008966 Adhesion domain SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 TIGRFAM TIGR04226 RrgB_K2N_iso_D2: fimbrial isopeptide formation D2 domain 340 431 1.5E-7 T 17-03-2017 IPR026466 Fimbrial isopeptide formation D2 domain SHXM_RS48170 d4f011c53e3f9d9869ba481a2fbaa115 467 TIGRFAM TIGR04226 RrgB_K2N_iso_D2: fimbrial isopeptide formation D2 domain 191 311 1.8E-7 T 17-03-2017 IPR026466 Fimbrial isopeptide formation D2 domain SHXM_RS11065 ea2fdbc49be525516496935bd92741db 748 Gene3D G3DSA:2.60.40.650 673 734 8.3E-4 T 17-03-2017 IPR005066 Moybdenum cofactor oxidoreductase, dimerisation GO:0016491|GO:0030151|GO:0055114 Reactome: R-HSA-1614517 SHXM_RS19095 fbe3c581acb948098c47c1acb9028c89 226 Pfam PF13829 Domain of unknown function (DUF4191) 8 224 1.2E-82 T 17-03-2017 IPR025445 Protein of unknown function DUF4191 SHXM_RS19095 fbe3c581acb948098c47c1acb9028c89 226 ProDom PD037701 MEMBRANE INTEGRAL TRANSMEMBRANE RV2219/MT2276 NARROWLY PROBABLE PRECURSOR SIGNAL MLCB22.21 1 211 4.0E-81 T 17-03-2017 SHXM_RS13805 71c4def6480eedb394a7aff2df09bff4 87 Gene3D G3DSA:3.40.50.720 9 79 1.0E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13805 71c4def6480eedb394a7aff2df09bff4 87 Pfam PF00107 Zinc-binding dehydrogenase 9 79 1.3E-7 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS13805 71c4def6480eedb394a7aff2df09bff4 87 SUPERFAMILY SSF51735 9 85 2.45E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS25380 fed77cced6f8ada95668cbd19e04ee8f 425 Pfam PF13581 Histidine kinase-like ATPase domain 312 384 2.3E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25380 fed77cced6f8ada95668cbd19e04ee8f 425 SUPERFAMILY SSF55874 307 418 2.1E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25380 fed77cced6f8ada95668cbd19e04ee8f 425 Gene3D G3DSA:3.30.565.10 310 420 2.2E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25380 fed77cced6f8ada95668cbd19e04ee8f 425 Pfam PF04024 PspC domain 15 70 1.1E-14 T 17-03-2017 IPR007168 Phage shock protein, PspC, N-terminal SHXM_RS08835 901c37f15a186ca4bcbfbf268685d3f4 139 Pfam PF13006 Insertion element 4 transposase N-terminal 1 46 1.9E-8 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 Pfam PF08281 Sigma-70, region 4 129 176 6.4E-11 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 Gene3D G3DSA:1.10.10.10 129 182 1.5E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 SUPERFAMILY SSF88946 4 104 1.1E-24 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 Pfam PF04542 Sigma-70 region 2 27 93 5.7E-17 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 SUPERFAMILY SSF88659 127 180 3.74E-9 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 Gene3D G3DSA:1.10.1740.10 6 110 5.5E-26 T 17-03-2017 SHXM_RS25085 75363e6d6acea8020207addfcc303a94 227 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 22 177 7.8E-18 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS20175 98213a819d45a520666da2d5e5c10345 274 Pfam PF14325 Domain of unknown function (DUF4383) 22 136 1.9E-11 T 17-03-2017 IPR025492 Protein of unknown function DUF4383 SHXM_RS39360 e855d8a95cdf7d32f04fc91541dcd855 233 Gene3D G3DSA:3.20.20.150 7 211 7.2E-44 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS39360 e855d8a95cdf7d32f04fc91541dcd855 233 SUPERFAMILY SSF51658 7 214 4.58E-45 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS39360 e855d8a95cdf7d32f04fc91541dcd855 233 Pfam PF01261 Xylose isomerase-like TIM barrel 20 215 5.1E-32 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS26480 09976c399548d67f289a4fffa338e874 568 Pfam PF06738 Putative threonine/serine exporter 148 388 8.2E-61 T 17-03-2017 IPR010619 Putative threonine/serine exporter SHXM_RS26480 09976c399548d67f289a4fffa338e874 568 Pfam PF12821 Threonine/Serine exporter, ThrE 413 538 3.5E-18 T 17-03-2017 IPR024528 Threonine/Serine exporter, ThrE SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 Gene3D G3DSA:1.10.10.10 4 73 4.7E-20 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 SUPERFAMILY SSF46785 4 79 8.44E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 SUPERFAMILY SSF46785 77 141 1.89E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 112 128 1.7E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 98 112 1.7E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 Gene3D G3DSA:1.10.10.10 79 139 5.0E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 Pfam PF00392 Bacterial regulatory proteins, gntR family 80 132 1.3E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 Pfam PF00392 Bacterial regulatory proteins, gntR family 9 70 1.1E-15 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 SMART SM00345 79 138 0.011 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS26730 dbedc013743039a00d0cfc4afdbcb158 148 SMART SM00345 13 70 1.0E-12 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS36510 a564c0e4393f349f3a2c7d7e29789d31 699 SUPERFAMILY SSF55874 546 664 1.96E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36510 a564c0e4393f349f3a2c7d7e29789d31 699 SMART SM00387 576 666 5.7E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36510 a564c0e4393f349f3a2c7d7e29789d31 699 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 577 664 3.0E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36510 a564c0e4393f349f3a2c7d7e29789d31 699 Gene3D G3DSA:3.30.565.10 545 665 5.6E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS36510 a564c0e4393f349f3a2c7d7e29789d31 699 Pfam PF07730 Histidine kinase 472 538 4.4E-10 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS19875 aafa2f20e5af2873a56556cd42908b98 210 Pfam PF00080 Copper/zinc superoxide dismutase (SODC) 93 206 4.9E-10 T 17-03-2017 IPR001424 Superoxide dismutase, copper/zinc binding domain GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS19875 aafa2f20e5af2873a56556cd42908b98 210 SUPERFAMILY SSF49329 92 207 5.37E-14 T 17-03-2017 IPR001424 Superoxide dismutase, copper/zinc binding domain GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS19875 aafa2f20e5af2873a56556cd42908b98 210 Gene3D G3DSA:2.60.40.200 92 205 3.7E-12 T 17-03-2017 IPR001424 Superoxide dismutase, copper/zinc binding domain GO:0006801|GO:0046872|GO:0055114 MetaCyc: PWY-6854|Reactome: R-HSA-3299685 SHXM_RS16645 e545e4fbf85ecb9fb441032b8d63f8dc 289 Pfam PF13560 Helix-turn-helix domain 10 88 8.1E-17 T 17-03-2017 SHXM_RS16645 e545e4fbf85ecb9fb441032b8d63f8dc 289 SMART SM00530 13 85 1.6E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS16645 e545e4fbf85ecb9fb441032b8d63f8dc 289 SUPERFAMILY SSF47413 26 83 2.7E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS16645 e545e4fbf85ecb9fb441032b8d63f8dc 289 Gene3D G3DSA:1.10.260.40 7 84 4.9E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS38080 be92018d11764bbe25519bdb2c1408f9 196 SUPERFAMILY SSF46689 16 96 2.74E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38080 be92018d11764bbe25519bdb2c1408f9 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 47 70 5.3E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38080 be92018d11764bbe25519bdb2c1408f9 196 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 27 40 5.3E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS38080 be92018d11764bbe25519bdb2c1408f9 196 Gene3D G3DSA:1.10.357.10 16 195 3.1E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS38080 be92018d11764bbe25519bdb2c1408f9 196 SUPERFAMILY SSF48498 93 195 6.5E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS38080 be92018d11764bbe25519bdb2c1408f9 196 Pfam PF00440 Bacterial regulatory proteins, tetR family 27 72 9.5E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS22260 1c16e0068e962d5b7b0cbedd02925513 315 TIGRFAM TIGR04382 myo_inos_iolC_N: 5-dehydro-2-deoxygluconokinase 5 312 3.5E-116 T 17-03-2017 IPR030830 5-dehydro-2-deoxygluconokinase KEGG: 00562+2.7.1.92 SHXM_RS22260 1c16e0068e962d5b7b0cbedd02925513 315 Gene3D G3DSA:3.40.1190.20 1 314 2.6E-105 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS22260 1c16e0068e962d5b7b0cbedd02925513 315 Pfam PF00294 pfkB family carbohydrate kinase 9 304 4.8E-54 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS22260 1c16e0068e962d5b7b0cbedd02925513 315 SUPERFAMILY SSF53613 4 312 1.29E-77 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS36875 7be3b81e25874110400d225f4d312aaa 384 SUPERFAMILY SSF56014 275 359 1.8E-11 T 17-03-2017 SHXM_RS36875 7be3b81e25874110400d225f4d312aaa 384 TIGRFAM TIGR00612 ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 18 360 2.0E-127 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS36875 7be3b81e25874110400d225f4d312aaa 384 PIRSF PIRSF004640 11 373 5.8E-146 T 17-03-2017 IPR016425 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial GO:0005506|GO:0008299|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS36875 7be3b81e25874110400d225f4d312aaa 384 Pfam PF04551 GcpE protein 22 361 2.3E-133 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS36875 7be3b81e25874110400d225f4d312aaa 384 SUPERFAMILY SSF51717 46 219 3.77E-9 T 17-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS36875 7be3b81e25874110400d225f4d312aaa 384 Hamap MF_00159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) [ispG]. 16 367 33.538 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS16585 3e149e76da981f5c7c9b8b9461868432 456 Gene3D G3DSA:3.20.20.80 93 360 3.2E-37 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS16585 3e149e76da981f5c7c9b8b9461868432 456 SUPERFAMILY SSF51445 94 360 2.75E-32 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS44015 bb93bfd6c08e856b529005abc1260c9b 329 Pfam PF00892 EamA-like transporter family 155 299 1.7E-14 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS44015 bb93bfd6c08e856b529005abc1260c9b 329 Pfam PF00892 EamA-like transporter family 14 143 4.2E-15 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS44015 bb93bfd6c08e856b529005abc1260c9b 329 SUPERFAMILY SSF103481 48 144 5.89E-12 T 17-03-2017 SHXM_RS44015 bb93bfd6c08e856b529005abc1260c9b 329 SUPERFAMILY SSF103481 200 303 5.75E-9 T 17-03-2017 SHXM_RS20725 a2423834b408b99d638de8cd88657b71 123 Gene3D G3DSA:2.102.10.10 19 118 4.7E-34 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS20725 a2423834b408b99d638de8cd88657b71 123 TIGRFAM TIGR02378 nirD_assim_sml: nitrite reductase [NAD(P)H], small subunit 20 118 4.9E-26 T 17-03-2017 IPR012748 Nitrite reductase [NAD(P)H] small subunit, NirD GO:0008942|GO:0042128|GO:0055114 SHXM_RS20725 a2423834b408b99d638de8cd88657b71 123 Pfam PF13806 Rieske-like [2Fe-2S] domain 19 119 1.2E-32 T 17-03-2017 IPR012748 Nitrite reductase [NAD(P)H] small subunit, NirD GO:0008942|GO:0042128|GO:0055114 SHXM_RS20725 a2423834b408b99d638de8cd88657b71 123 SUPERFAMILY SSF50022 19 117 1.27E-28 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS00170 e83ff705fc66afc266565c9150fb0bff 254 SMART SM00382 100 231 1.3E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS00170 e83ff705fc66afc266565c9150fb0bff 254 PIRSF PIRSF003073 2 251 5.4E-81 T 17-03-2017 IPR028350 DNA replication protein DnaC/insertion sequence putative ATP-binding protein SHXM_RS00170 e83ff705fc66afc266565c9150fb0bff 254 Gene3D G3DSA:3.40.50.300 57 230 2.1E-27 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00170 e83ff705fc66afc266565c9150fb0bff 254 SUPERFAMILY SSF52540 67 225 1.02E-25 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00170 e83ff705fc66afc266565c9150fb0bff 254 Pfam PF01695 IstB-like ATP binding protein 58 231 1.6E-48 T 17-03-2017 IPR002611 IstB-like ATP-binding protein GO:0005524 SHXM_RS18395 f2a4511722ac41a7f6c1f95b688f29d1 136 Pfam PF01042 Endoribonuclease L-PSP 21 129 1.1E-17 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS18395 f2a4511722ac41a7f6c1f95b688f29d1 136 SUPERFAMILY SSF55298 8 132 1.88E-26 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS18395 f2a4511722ac41a7f6c1f95b688f29d1 136 Gene3D G3DSA:3.30.1330.40 7 132 1.5E-34 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS33645 1a1955dde5191b9bcf9f01ec3fbf7a94 343 TIGRFAM TIGR00330 glpX: fructose-1,6-bisphosphatase, class II 19 330 1.6E-114 T 17-03-2017 IPR004464 Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase GO:0006071|GO:0006094|GO:0042132 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484 SHXM_RS33645 1a1955dde5191b9bcf9f01ec3fbf7a94 343 Gene3D G3DSA:3.30.540.10 190 337 2.3E-45 T 17-03-2017 SHXM_RS33645 1a1955dde5191b9bcf9f01ec3fbf7a94 343 Gene3D G3DSA:3.30.540.10 17 189 8.1E-63 T 17-03-2017 SHXM_RS33645 1a1955dde5191b9bcf9f01ec3fbf7a94 343 PIRSF PIRSF004532 17 337 1.1E-144 T 17-03-2017 IPR004464 Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase GO:0006071|GO:0006094|GO:0042132 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484 SHXM_RS33645 1a1955dde5191b9bcf9f01ec3fbf7a94 343 Pfam PF03320 Bacterial fructose-1,6-bisphosphatase, glpX-encoded 19 326 7.5E-142 T 17-03-2017 IPR004464 Fructose-1,6-bisphosphatase class 2/Sedoheputulose-1,7-bisphosphatase GO:0006071|GO:0006094|GO:0042132 KEGG: 00010+3.1.3.11|KEGG: 00030+3.1.3.11|KEGG: 00051+3.1.3.11|KEGG: 00680+3.1.3.11|KEGG: 00710+3.1.3.11|MetaCyc: PWY-5484 SHXM_RS33645 1a1955dde5191b9bcf9f01ec3fbf7a94 343 SUPERFAMILY SSF56655 17 328 5.04E-110 T 17-03-2017 SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 SUPERFAMILY SSF53067 90 383 3.51E-44 T 17-03-2017 SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 ProSitePatterns PS01125 ROK family signature. 219 246 - T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 Gene3D G3DSA:1.10.10.10 16 86 2.1E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 Gene3D G3DSA:3.30.420.40 224 367 8.9E-44 T 17-03-2017 SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 Pfam PF00480 ROK family 137 382 4.5E-46 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 Gene3D G3DSA:3.30.420.40 87 223 9.6E-25 T 17-03-2017 SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 SUPERFAMILY SSF46785 17 79 2.2E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04685 82afd9c3987f58e5efba8a257f8e95f1 396 Pfam PF13412 Winged helix-turn-helix DNA-binding 24 63 3.6E-6 T 17-03-2017 SHXM_RS36675 dab37069fc247246193eb432f62327e4 392 ProSitePatterns PS01315 Phosphatidate cytidylyltransferase signature. 346 372 - T 17-03-2017 IPR000374 Phosphatidate cytidylyltransferase GO:0016020|GO:0016772 KEGG: 00564+2.7.7.41|KEGG: 04070+2.7.7.41|MetaCyc: PWY-5667|MetaCyc: PWY-5981 SHXM_RS36675 dab37069fc247246193eb432f62327e4 392 Pfam PF01148 Cytidylyltransferase family 132 388 5.6E-63 T 17-03-2017 SHXM_RS01070 2069e351beb0687ca200554d4f7ff4ae 286 Pfam PF00456 Transketolase, thiamine diphosphate binding domain 26 274 6.6E-37 T 17-03-2017 IPR005474 Transketolase, N-terminal KEGG: 00730+2.2.1.7|KEGG: 00900+2.2.1.7|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7560 SHXM_RS01070 2069e351beb0687ca200554d4f7ff4ae 286 SUPERFAMILY SSF52518 4 271 2.95E-71 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS01070 2069e351beb0687ca200554d4f7ff4ae 286 Gene3D G3DSA:3.40.50.970 3 282 5.8E-77 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 56 1.3E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 Gene3D G3DSA:1.10.10.60 1 64 3.6E-22 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 SUPERFAMILY SSF46689 2 66 3.03E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 Gene3D G3DSA:1.10.357.10 71 194 1.7E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 SUPERFAMILY SSF48498 78 193 2.38E-26 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 Pfam PF13977 Bacterial transcriptional repressor 107 192 4.1E-7 T 17-03-2017 SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 6.5E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS14255 c732170374dfabedcd52f798ae51538c 194 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 6.5E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 Gene3D G3DSA:1.10.10.10 3 82 4.0E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 Gene3D G3DSA:3.40.190.10 193 261 4.0E-14 T 17-03-2017 SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 SUPERFAMILY SSF53850 89 292 1.28E-30 T 17-03-2017 SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 Pfam PF03466 LysR substrate binding domain 89 287 6.9E-34 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 SUPERFAMILY SSF46785 2 111 1.41E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 Gene3D G3DSA:3.40.190.10 90 192 1.3E-25 T 17-03-2017 SHXM_RS40640 eab06e34e9f3cb296774902a50b76f0f 307 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 5 62 6.1E-15 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS12385 8683ed3a2c2a4be30385210c8ef84b08 166 SUPERFAMILY SSF47413 4 73 5.04E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12385 8683ed3a2c2a4be30385210c8ef84b08 166 Pfam PF01381 Helix-turn-helix 13 69 1.2E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS12385 8683ed3a2c2a4be30385210c8ef84b08 166 Gene3D G3DSA:1.10.260.40 3 75 3.6E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS12385 8683ed3a2c2a4be30385210c8ef84b08 166 SMART SM00530 12 69 2.1E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS34130 a8c53138ad5bd0ea4ddbd38108d21c9c 171 Pfam PF06210 Protein of unknown function (DUF1003) 39 140 1.7E-38 T 17-03-2017 IPR010406 Protein of unknown function DUF1003 SHXM_RS44855 7dab6c7072f2c0d03ff9df57560a9c1d 286 Pfam PF13560 Helix-turn-helix domain 15 74 2.1E-10 T 17-03-2017 SHXM_RS44855 7dab6c7072f2c0d03ff9df57560a9c1d 286 Gene3D G3DSA:1.10.260.40 12 73 8.8E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS44855 7dab6c7072f2c0d03ff9df57560a9c1d 286 SMART SM00530 18 73 9.0E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS44855 7dab6c7072f2c0d03ff9df57560a9c1d 286 SUPERFAMILY SSF47413 14 73 5.63E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 20 31 4.2E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 31 44 4.2E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 55 75 4.2E-7 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 SMART SM00422 21 88 1.4E-21 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 SUPERFAMILY SSF46955 21 121 4.03E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 Pfam PF13411 MerR HTH family regulatory protein 21 86 2.4E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36055 34db4b38627d0b9682ac00b398effb37 330 Gene3D G3DSA:1.10.1660.10 21 127 3.3E-27 T 17-03-2017 SHXM_RS37220 df497660d3317cdc20aa3892aace857f 100 Pfam PF05437 Branched-chain amino acid transport protein (AzlD) 3 98 3.3E-13 T 17-03-2017 IPR008407 Branched-chain amino acid transport, AzlD SHXM_RS23975 e9fc519ce1c726ef47fa0dcb790fa48c 490 Pfam PF00474 Sodium:solute symporter family 35 400 2.7E-12 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS17355 9ef0e38a83a9129c7e7716d7784927b5 129 Pfam PF11298 Protein of unknown function (DUF3099) 11 80 2.7E-24 T 17-03-2017 IPR021449 Protein of unknown function DUF3099 SHXM_RS13315 c25f00761978750929200edea8946fe4 341 SUPERFAMILY SSF102114 23 309 4.51E-48 T 17-03-2017 SHXM_RS13315 c25f00761978750929200edea8946fe4 341 Pfam PF11946 Domain of unknown function (DUF3463) 197 329 2.6E-56 T 17-03-2017 IPR022563 Domain of unknown function DUF3463 SHXM_RS13315 c25f00761978750929200edea8946fe4 341 Pfam PF04055 Radical SAM superfamily 35 188 7.1E-16 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS13315 c25f00761978750929200edea8946fe4 341 TIGRFAM TIGR03470 HpnH: hopanoid biosynthesis associated radical SAM protein HpnH 1 319 2.9E-160 T 17-03-2017 IPR017833 Hopanoid biosynthesis associated radical SAM protein HpnH SHXM_RS13315 c25f00761978750929200edea8946fe4 341 Gene3D G3DSA:3.20.20.70 19 311 9.5E-41 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS07595 ffd71cea9309ba7d950614f697598737 459 TIGRFAM TIGR00784 citMHS: citrate transporter 25 457 1.8E-153 T 17-03-2017 IPR014738 Citrate transporter GO:0015137|GO:0015746 SHXM_RS07595 ffd71cea9309ba7d950614f697598737 459 Pfam PF03600 Citrate transporter 38 402 1.7E-45 T 17-03-2017 IPR004680 Citrate transporter-like domain GO:0016021|GO:0055085 SHXM_RS03385 586fb2f8d77c12f517df34f96049c0ec 243 Pfam PF01522 Polysaccharide deacetylase 47 164 1.9E-24 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS03385 586fb2f8d77c12f517df34f96049c0ec 243 SUPERFAMILY SSF88713 48 238 4.73E-47 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS03385 586fb2f8d77c12f517df34f96049c0ec 243 Gene3D G3DSA:3.20.20.370 49 238 3.4E-43 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS34270 12db94ea3d040438e381ae18c3eed62e 129 SUPERFAMILY SSF46767 21 81 6.15E-14 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS34270 12db94ea3d040438e381ae18c3eed62e 129 Pfam PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain 23 83 4.9E-18 T 17-03-2017 IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding GO:0003824|GO:0006281 Reactome: R-HSA-5657655 SHXM_RS34270 12db94ea3d040438e381ae18c3eed62e 129 Gene3D G3DSA:1.10.10.10 22 80 1.2E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39225 9061464bb35eb709511c39bde05406e4 101 SUPERFAMILY SSF47413 30 98 3.38E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39225 9061464bb35eb709511c39bde05406e4 101 SMART SM00530 41 96 1.3E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS39225 9061464bb35eb709511c39bde05406e4 101 Gene3D G3DSA:1.10.260.40 36 96 6.0E-16 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39225 9061464bb35eb709511c39bde05406e4 101 Pfam PF01381 Helix-turn-helix 43 92 4.0E-12 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS19450 bf8ffb93ee6d8281b5926e2ed0510a28 82 Pfam PF13358 DDE superfamily endonuclease 12 77 5.0E-7 T 17-03-2017 SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 Pfam PF00582 Universal stress protein family 4 136 4.4E-20 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 Pfam PF00582 Universal stress protein family 156 274 3.4E-6 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 SUPERFAMILY SSF52402 4 141 1.51E-25 T 17-03-2017 SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 PRINTS PR01438 Universal stress protein signature 2 20 1.3E-8 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 PRINTS PR01438 Universal stress protein signature 114 136 1.3E-8 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 PRINTS PR01438 Universal stress protein signature 96 108 1.3E-8 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 SUPERFAMILY SSF52402 147 274 1.93E-11 T 17-03-2017 SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 Gene3D G3DSA:3.40.50.620 130 274 3.7E-19 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS08010 ad180c171921d307da03be9d26f61b79 276 Gene3D G3DSA:3.40.50.620 1 129 1.4E-28 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS33795 889c29ba8a347af6a454d3bdc6778c77 553 PIRSF PIRSF006060 2 461 9.5E-77 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS33795 889c29ba8a347af6a454d3bdc6778c77 553 Pfam PF13520 Amino acid permease 15 426 2.7E-49 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS35665 5b08f87bb58b628364c99f90e86c8fc5 235 Gene3D G3DSA:1.10.10.10 173 217 3.4E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35665 5b08f87bb58b628364c99f90e86c8fc5 235 SUPERFAMILY SSF52172 13 167 2.28E-31 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS35665 5b08f87bb58b628364c99f90e86c8fc5 235 Gene3D G3DSA:3.40.50.2300 11 134 1.2E-27 T 17-03-2017 SHXM_RS35665 5b08f87bb58b628364c99f90e86c8fc5 235 PIRSF PIRSF006171 12 235 1.7E-71 T 17-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 SHXM_RS35665 5b08f87bb58b628364c99f90e86c8fc5 235 Pfam PF00072 Response regulator receiver domain 16 127 1.1E-20 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS35665 5b08f87bb58b628364c99f90e86c8fc5 235 SMART SM00448 14 127 3.6E-22 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS13440 1146587648e64889119c5326dd9cb47d 328 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 250 2.6E-56 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS13440 1146587648e64889119c5326dd9cb47d 328 Gene3D G3DSA:3.40.50.720 1 169 2.5E-48 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13440 1146587648e64889119c5326dd9cb47d 328 SUPERFAMILY SSF51735 1 318 7.16E-87 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13440 1146587648e64889119c5326dd9cb47d 328 TIGRFAM TIGR01179 galE: UDP-glucose 4-epimerase GalE 4 318 3.8E-95 T 17-03-2017 IPR005886 UDP-glucose 4-epimerase GalE GO:0003978|GO:0006012 KEGG: 00052+5.1.3.2|KEGG: 00520+5.1.3.2|MetaCyc: PWY-3821|MetaCyc: PWY-6317|MetaCyc: PWY-6397|MetaCyc: PWY-6527|MetaCyc: PWY-7328|MetaCyc: PWY-7344|Reactome: R-HSA-5609977|Reactome: R-HSA-70370 SHXM_RS13440 1146587648e64889119c5326dd9cb47d 328 Gene3D G3DSA:3.90.25.10 170 218 5.1E-34 T 17-03-2017 SHXM_RS13440 1146587648e64889119c5326dd9cb47d 328 Gene3D G3DSA:3.90.25.10 252 318 5.1E-34 T 17-03-2017 SHXM_RS06465 7d905584df720f76a1d7d0346a3f996a 270 SUPERFAMILY SSF53335 13 247 8.53E-50 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06465 7d905584df720f76a1d7d0346a3f996a 270 Gene3D G3DSA:3.40.50.150 26 270 2.1E-49 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06465 7d905584df720f76a1d7d0346a3f996a 270 Pfam PF08241 Methyltransferase domain 70 166 1.8E-19 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS12010 be1f167b324a85a0462b8331ad424f36 220 Gene3D G3DSA:3.40.50.10320 2 186 3.0E-16 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS12010 be1f167b324a85a0462b8331ad424f36 220 Pfam PF02585 GlcNAc-PI de-N-acetylase 5 133 9.4E-12 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS12010 be1f167b324a85a0462b8331ad424f36 220 SUPERFAMILY SSF102588 1 199 4.05E-25 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS33150 1c2827959d46464691b026078932d4fc 123 Pfam PF13586 Transposase DDE domain 34 111 2.7E-10 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS14675 88b057c0355fc446838b9c84ddfac8d1 277 Pfam PF04951 D-aminopeptidase 1 262 1.1E-91 T 17-03-2017 IPR007035 Peptidase M55, D-aminopeptidase SHXM_RS14675 88b057c0355fc446838b9c84ddfac8d1 277 Gene3D G3DSA:3.40.50.10780 1 206 4.1E-75 T 17-03-2017 IPR027476 D-aminopeptidase, N-terminal SHXM_RS14675 88b057c0355fc446838b9c84ddfac8d1 277 PIRSF PIRSF015853 1 274 2.2E-93 T 17-03-2017 IPR007035 Peptidase M55, D-aminopeptidase SHXM_RS14675 88b057c0355fc446838b9c84ddfac8d1 277 Gene3D G3DSA:3.30.1360.130 216 267 1.8E-7 T 17-03-2017 SHXM_RS14675 88b057c0355fc446838b9c84ddfac8d1 277 SUPERFAMILY SSF63992 1 267 3.01E-83 T 17-03-2017 IPR007035 Peptidase M55, D-aminopeptidase SHXM_RS37015 35408175d04a97e8f93fc7929a1620a3 103 Pfam PF06013 Proteins of 100 residues with WXG 8 91 7.3E-11 T 17-03-2017 IPR010310 Type VII secretion system ESAT-6-like SHXM_RS37015 35408175d04a97e8f93fc7929a1620a3 103 Gene3D G3DSA:1.10.287.1060 7 99 4.1E-14 T 17-03-2017 SHXM_RS37015 35408175d04a97e8f93fc7929a1620a3 103 TIGRFAM TIGR03930 WXG100_ESAT6: WXG100 family type VII secretion target 8 96 1.5E-13 T 17-03-2017 IPR010310 Type VII secretion system ESAT-6-like SHXM_RS37015 35408175d04a97e8f93fc7929a1620a3 103 SUPERFAMILY SSF140453 7 99 6.93E-15 T 17-03-2017 IPR010310 Type VII secretion system ESAT-6-like SHXM_RS29655 1a153e1de3793efe54377e9540522662 530 Pfam PF00149 Calcineurin-like phosphoesterase 278 445 1.7E-13 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS29655 1a153e1de3793efe54377e9540522662 530 SUPERFAMILY SSF56300 274 476 3.01E-31 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS29655 1a153e1de3793efe54377e9540522662 530 Gene3D G3DSA:3.60.21.10 277 468 5.0E-19 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS47825 dd7fecbd501266a2d703c5d615630e7d 124 Gene3D G3DSA:1.10.10.10 6 109 2.4E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47825 dd7fecbd501266a2d703c5d615630e7d 124 SUPERFAMILY SSF46785 11 112 5.65E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47825 dd7fecbd501266a2d703c5d615630e7d 124 Pfam PF01638 HxlR-like helix-turn-helix 21 104 1.7E-18 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS24615 d5860f22b33367dc833c2a928ead39ac 205 Pfam PF13624 SurA N-terminal domain 32 149 2.2E-6 T 17-03-2017 SHXM_RS24615 d5860f22b33367dc833c2a928ead39ac 205 SUPERFAMILY SSF109998 33 158 3.92E-10 T 17-03-2017 IPR027304 Trigger factor/SurA domain SHXM_RS18615 4958ba0344b5f1c570a361a846c6a2f3 351 Pfam PF07726 ATPase family associated with various cellular activities (AAA) 47 176 6.9E-65 T 17-03-2017 IPR011703 ATPase, AAA-3 GO:0005524|GO:0016887 SHXM_RS18615 4958ba0344b5f1c570a361a846c6a2f3 351 Gene3D G3DSA:1.10.8.300 209 315 2.6E-34 T 17-03-2017 SHXM_RS18615 4958ba0344b5f1c570a361a846c6a2f3 351 Gene3D G3DSA:3.40.50.300 33 193 2.2E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18615 4958ba0344b5f1c570a361a846c6a2f3 351 SUPERFAMILY SSF52540 16 291 2.67E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18615 4958ba0344b5f1c570a361a846c6a2f3 351 PIRSF PIRSF002849 2 321 3.9E-130 T 17-03-2017 IPR016366 ATPase chaperone, AAA-type, MoxR, predicted SHXM_RS40860 eff62e63a3281a0f80279177e958624a 262 Pfam PF03649 Uncharacterised protein family (UPF0014) 23 251 1.6E-42 T 17-03-2017 IPR005226 UPF0014 family SHXM_RS14870 680a6e99a127839ae1bec2e3ca9fb8b7 280 Gene3D G3DSA:3.60.110.10 5 279 3.3E-87 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS14870 680a6e99a127839ae1bec2e3ca9fb8b7 280 Pfam PF00795 Carbon-nitrogen hydrolase 6 261 1.5E-67 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS14870 680a6e99a127839ae1bec2e3ca9fb8b7 280 SUPERFAMILY SSF56317 4 278 1.57E-80 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 TIGRFAM TIGR00178 monomer_idh: isocitrate dehydrogenase, NADP-dependent 3 738 0.0 T 17-03-2017 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 Pfam PF03971 Monomeric isocitrate dehydrogenase 5 735 0.0 T 17-03-2017 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 Gene3D G3DSA:3.40.718.10 536 643 7.6E-33 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 Gene3D G3DSA:3.40.718.10 337 360 7.6E-33 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 Gene3D G3DSA:3.40.718.10 146 284 7.6E-33 T 17-03-2017 IPR024084 Isopropylmalate dehydrogenase-like domain GO:0016616|GO:0055114 Reactome: R-HSA-71403 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 PIRSF PIRSF009407 1 739 0.0 T 17-03-2017 IPR004436 Isocitrate dehydrogenase NADP-dependent, monomeric GO:0004450|GO:0006099|GO:0055114 KEGG: 00020+1.1.1.42|KEGG: 00480+1.1.1.42|KEGG: 00720+1.1.1.42|MetaCyc: PWY-5913|MetaCyc: PWY-6549|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7124|MetaCyc: PWY-7254|MetaCyc: PWY-7268 SHXM_RS13025 4a75f71920a0656d99fed4d4cc87a701 739 SUPERFAMILY SSF53659 4 738 0.0 T 17-03-2017 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00385 P450 superfamily signature 318 329 4.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00385 P450 superfamily signature 393 402 4.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00385 P450 superfamily signature 266 283 4.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00385 P450 superfamily signature 402 413 4.9E-11 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 Pfam PF00067 Cytochrome P450 19 439 9.1E-80 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 14 31 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 346 360 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 386 402 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 313 329 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 257 283 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 362 380 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 PRINTS PR00465 E-class P450 group IV signature 402 420 1.1E-20 T 17-03-2017 IPR002403 Cytochrome P450, E-class, group IV GO:0004497|GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 395 404 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 SUPERFAMILY SSF48264 18 453 6.94E-105 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS43385 733e71153fafa5268fb48713502fc044 453 Gene3D G3DSA:1.10.630.10 18 453 1.9E-113 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS41700 bf1bb584143455eb9bbeacf8f0fc974a 359 Pfam PF02653 Branched-chain amino acid transport system / permease component 62 341 2.1E-38 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS50550 3b7247d64da62fb175e986b3035e719a 447 Gene3D G3DSA:3.40.190.10 52 167 6.4E-27 T 17-03-2017 SHXM_RS50550 3b7247d64da62fb175e986b3035e719a 447 Gene3D G3DSA:3.40.190.10 335 368 6.4E-27 T 17-03-2017 SHXM_RS50550 3b7247d64da62fb175e986b3035e719a 447 SUPERFAMILY SSF53850 26 443 2.17E-62 T 17-03-2017 SHXM_RS50550 3b7247d64da62fb175e986b3035e719a 447 Gene3D G3DSA:3.40.190.10 168 334 3.6E-37 T 17-03-2017 SHXM_RS50550 3b7247d64da62fb175e986b3035e719a 447 Pfam PF13416 Bacterial extracellular solute-binding protein 72 367 2.4E-38 T 17-03-2017 SHXM_RS40585 f6a46dcd36c75eebf3fa1a6b1a161366 62 Gene3D G3DSA:3.90.245.10 1 48 9.2E-4 T 17-03-2017 IPR001910 Inosine/uridine-preferring nucleoside hydrolase domain SHXM_RS00210 5c619264430a25ddb586aae7277ea317 283 SUPERFAMILY SSF55729 175 275 3.72E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS00210 5c619264430a25ddb586aae7277ea317 283 Pfam PF12746 GNAT acetyltransferase 173 274 7.7E-23 T 17-03-2017 IPR027365 GNAT acetyltransferase YdfB-like SHXM_RS00210 5c619264430a25ddb586aae7277ea317 283 Gene3D G3DSA:3.40.630.30 170 276 2.7E-13 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 Gene3D G3DSA:3.50.50.60 5 182 2.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 Gene3D G3DSA:3.50.50.60 279 337 2.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 Pfam PF01494 FAD binding domain 6 341 2.0E-17 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 SUPERFAMILY SSF51905 5 177 5.93E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 SUPERFAMILY SSF51905 278 362 5.93E-42 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 156 171 1.1E-9 T 17-03-2017 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 7 29 1.1E-9 T 17-03-2017 SHXM_RS13385 67f01ac34d656fe6a05b0da3c791fe0c 461 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 283 298 1.1E-9 T 17-03-2017 SHXM_RS22915 e9b3d511c1885529c71a5c9083c7a07a 426 Gene3D G3DSA:3.30.565.10 282 386 9.0E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22915 e9b3d511c1885529c71a5c9083c7a07a 426 SUPERFAMILY SSF55874 280 385 1.75E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS22915 e9b3d511c1885529c71a5c9083c7a07a 426 Pfam PF07730 Histidine kinase 199 264 1.1E-14 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS31525 d711243b1c4ebda1af788c6773c10dbc 393 Pfam PF09445 RNA cap guanine-N2 methyltransferase 103 161 4.8E-8 T 17-03-2017 IPR019012 RNA cap guanine-N2 methyltransferase GO:0001510|GO:0008168|GO:0009452 Reactome: R-HSA-1368082|Reactome: R-HSA-1368108|Reactome: R-HSA-191859|Reactome: R-HSA-1989781|Reactome: R-HSA-2032785|Reactome: R-HSA-2151201|Reactome: R-HSA-2426168|Reactome: R-HSA-381340|Reactome: R-HSA-400206|Reactome: R-HSA-400253 SHXM_RS31525 d711243b1c4ebda1af788c6773c10dbc 393 SUPERFAMILY SSF53335 67 231 4.47E-27 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS31525 d711243b1c4ebda1af788c6773c10dbc 393 Gene3D G3DSA:3.40.50.150 72 179 1.4E-18 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS50665 51b6992e819ec9dcbb5ded8758e5eb18 267 Pfam PF07920 Protein of unknown function (DUF1684) 120 258 6.4E-23 T 17-03-2017 IPR012467 Protein of unknown function DUF1684 SHXM_RS16565 aaf85131418d5afe92b821ad8dbaed37 367 Gene3D G3DSA:3.90.550.10 12 245 3.1E-31 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS16565 aaf85131418d5afe92b821ad8dbaed37 367 Pfam PF00535 Glycosyl transferase family 2 14 192 1.7E-17 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS16565 aaf85131418d5afe92b821ad8dbaed37 367 SUPERFAMILY SSF53448 7 254 8.44E-37 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS41340 c45bb453ce355d1b9ce491e84f3c0975 142 SUPERFAMILY SSF50475 7 138 9.17E-21 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS41340 c45bb453ce355d1b9ce491e84f3c0975 142 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 10 95 5.7E-10 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS41340 c45bb453ce355d1b9ce491e84f3c0975 142 Gene3D G3DSA:2.30.110.10 13 138 2.0E-20 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS50520 de64f5b5910d0b247418b52ea6769b5c 238 Gene3D G3DSA:3.30.420.10 4 153 3.3E-28 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50520 de64f5b5910d0b247418b52ea6769b5c 238 Pfam PF00665 Integrase core domain 9 123 3.1E-23 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS50520 de64f5b5910d0b247418b52ea6769b5c 238 SUPERFAMILY SSF53098 3 165 3.19E-31 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 Gene3D G3DSA:3.40.50.720 3 254 7.9E-58 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 17 253 4.4E-41 T 17-03-2017 SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 126 142 1.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 173 190 1.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 1.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 217 237 1.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 152 171 1.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 9 26 1.3E-26 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41900 6a09fa6995a94f41ca0b48a648c625bd 257 SUPERFAMILY SSF51735 7 254 4.05E-59 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31960 e4e752a956b6eea134ba5a7fdb47917d 567 Gene3D G3DSA:2.40.10.10 14 48 7.8E-5 T 17-03-2017 SHXM_RS31960 e4e752a956b6eea134ba5a7fdb47917d 567 Pfam PF13365 Trypsin-like peptidase domain 27 178 4.9E-9 T 17-03-2017 SHXM_RS31960 e4e752a956b6eea134ba5a7fdb47917d 567 SUPERFAMILY SSF50494 15 213 2.28E-14 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 SUPERFAMILY SSF50129 1 150 8.22E-38 T 17-03-2017 IPR011032 GroES-like SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 SMART SM00829 10 301 2.5E-16 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 Gene3D G3DSA:3.90.180.10 1 146 9.4E-42 T 17-03-2017 IPR011032 GroES-like SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 Gene3D G3DSA:3.40.50.720 147 233 4.8E-23 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 27 88 2.4E-9 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 SUPERFAMILY SSF51735 114 233 9.43E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40275 4351fb3dc21b2762c5e74a1b9a42968b 304 Pfam PF13602 Zinc-binding dehydrogenase 183 301 9.7E-13 T 17-03-2017 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 Gene3D G3DSA:3.10.170.10 57 192 4.3E-43 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 SUPERFAMILY SSF55486 74 359 7.51E-81 T 17-03-2017 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 281 297 3.5E-29 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 179 195 3.5E-29 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 143 163 3.5E-29 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 200 211 3.5E-29 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 Gene3D G3DSA:1.10.390.10 193 359 1.6E-52 T 17-03-2017 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 191 359 6.4E-51 T 17-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 SHXM_RS21220 ce39009249720846943c0dceb47407a2 369 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 79 188 2.2E-27 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS19870 ed6e9a85bde6d385e1cfe08baf0a9851 199 SUPERFAMILY SSF109604 17 146 2.83E-23 T 17-03-2017 SHXM_RS19870 ed6e9a85bde6d385e1cfe08baf0a9851 199 Gene3D G3DSA:1.10.3210.10 16 142 9.6E-27 T 17-03-2017 IPR006674 HD domain SHXM_RS19870 ed6e9a85bde6d385e1cfe08baf0a9851 199 SMART SM00471 40 149 3.0E-4 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS19870 ed6e9a85bde6d385e1cfe08baf0a9851 199 Pfam PF13023 HD domain 102 147 4.7E-6 T 17-03-2017 IPR006674 HD domain SHXM_RS19870 ed6e9a85bde6d385e1cfe08baf0a9851 199 Pfam PF13023 HD domain 25 89 8.0E-14 T 17-03-2017 IPR006674 HD domain SHXM_RS06095 32bf4fbc21dd2b8f327d154257d08071 344 Pfam PF06089 L-asparaginase II 31 334 1.1E-109 T 17-03-2017 IPR010349 L-asparaginase II SHXM_RS31870 0389a64564bb2d4a91bf64383a97e9de 219 Pfam PF13578 Methyltransferase domain 78 181 1.8E-19 T 17-03-2017 SHXM_RS31870 0389a64564bb2d4a91bf64383a97e9de 219 Gene3D G3DSA:3.40.50.150 51 218 3.3E-46 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS31870 0389a64564bb2d4a91bf64383a97e9de 219 SUPERFAMILY SSF53335 49 217 2.57E-35 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 Gene3D G3DSA:3.50.50.60 276 359 4.5E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 Gene3D G3DSA:3.50.50.60 6 183 4.5E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 Pfam PF01494 FAD binding domain 6 353 6.5E-41 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 SUPERFAMILY SSF51905 6 178 5.99E-57 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 SUPERFAMILY SSF51905 275 390 5.99E-57 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 288 303 1.4E-23 T 17-03-2017 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 157 172 1.4E-23 T 17-03-2017 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 8 30 1.4E-23 T 17-03-2017 SHXM_RS22895 52d22fd848ff24592e0a2d551474a212 411 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 303 319 1.4E-23 T 17-03-2017 SHXM_RS46440 53d1d8355a9d75dc05f4a23aa917c072 404 Gene3D G3DSA:3.40.50.1110 198 389 4.6E-35 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS46440 53d1d8355a9d75dc05f4a23aa917c072 404 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 200 384 9.3E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS46440 53d1d8355a9d75dc05f4a23aa917c072 404 SUPERFAMILY SSF52266 195 390 3.21E-46 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS26025 5b6b310e86eb5c6566c5c7d3ebf27c98 160 SMART SM01058 2 112 1.2E-32 T 17-03-2017 IPR003711 CarD-like/TRCF domain SHXM_RS26025 5b6b310e86eb5c6566c5c7d3ebf27c98 160 SUPERFAMILY SSF141259 2 65 3.66E-15 T 17-03-2017 IPR003711 CarD-like/TRCF domain SHXM_RS26025 5b6b310e86eb5c6566c5c7d3ebf27c98 160 Pfam PF02559 CarD-like/TRCF domain 3 110 1.4E-15 T 17-03-2017 IPR003711 CarD-like/TRCF domain SHXM_RS35725 d96799359ae802d8e47c3372adf75e1b 264 Pfam PF03211 Pectate lyase 37 236 5.4E-78 T 17-03-2017 IPR004898 Pectate lyase, catalytic GO:0005576|GO:0030570 KEGG: 00040+4.2.2.2 SHXM_RS35725 d96799359ae802d8e47c3372adf75e1b 264 SUPERFAMILY SSF51126 46 225 5.53E-55 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS35725 d96799359ae802d8e47c3372adf75e1b 264 Gene3D G3DSA:2.160.20.10 51 263 2.7E-86 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS04265 965cd40ca64bd12baf1be3d2fa92a7fd 368 Gene3D G3DSA:3.40.50.150 120 282 3.4E-24 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04265 965cd40ca64bd12baf1be3d2fa92a7fd 368 Pfam PF13489 Methyltransferase domain 120 279 3.6E-21 T 17-03-2017 SHXM_RS04265 965cd40ca64bd12baf1be3d2fa92a7fd 368 SUPERFAMILY SSF53335 95 297 8.92E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS48550 4e5b24186bb6cd40e4a0c36371ede783 330 SUPERFAMILY SSF51412 3 319 1.44E-65 T 17-03-2017 SHXM_RS48550 4e5b24186bb6cd40e4a0c36371ede783 330 Pfam PF03060 Nitronate monooxygenase 6 310 5.6E-54 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS48550 4e5b24186bb6cd40e4a0c36371ede783 330 SMART SM01240 1 251 0.0091 T 17-03-2017 SHXM_RS48550 4e5b24186bb6cd40e4a0c36371ede783 330 Gene3D G3DSA:3.20.20.70 3 306 1.8E-71 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 Pfam PF13305 WHG domain 92 173 6.8E-15 T 17-03-2017 IPR025996 WHG domain SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 SUPERFAMILY SSF48498 85 188 2.73E-20 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 Gene3D G3DSA:1.10.357.10 66 190 1.5E-26 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 Gene3D G3DSA:1.10.10.60 5 65 3.1E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 SUPERFAMILY SSF46689 7 79 7.18E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 1.9E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 3.6E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS47185 b4b01248940924f6e96e063148f8c45c 192 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 3.6E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34175 8c40fd8e65b5cac96c853d6e78cd737f 201 TIGRFAM TIGR00427 TIGR00427: membrane protein, MarC family 6 194 5.3E-42 T 17-03-2017 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 SHXM_RS34175 8c40fd8e65b5cac96c853d6e78cd737f 201 Pfam PF01914 MarC family integral membrane protein 6 196 5.0E-46 T 17-03-2017 IPR002771 Multiple antibiotic resistance (MarC)-related GO:0016021 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 Hamap MF_01396 ATP synthase subunit c [atpH]. 13 79 12.284 T 17-03-2017 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 Gene3D G3DSA:1.20.20.10 19 78 4.5E-19 T 17-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 Pfam PF00137 ATP synthase subunit C 21 77 9.9E-11 T 17-03-2017 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 TIGRFAM TIGR01260 ATP_synt_c: ATP synthase F0, C subunit 24 78 1.3E-12 T 17-03-2017 IPR005953 ATPase, F0 complex, subunit C, bacterial/chloroplast GO:0015078|GO:0015986|GO:0045263 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 ProSitePatterns PS00605 ATP synthase c subunit signature. 44 65 - T 17-03-2017 IPR020537 ATPase, F0 complex, subunit C, DCCD-binding site Reactome: R-HSA-163210 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 SUPERFAMILY SSF81333 19 78 4.18E-16 T 17-03-2017 IPR002379 V-ATPase proteolipid subunit C-like domain GO:0015078|GO:0015991|GO:0033177 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 PRINTS PR00124 ATP synthase C subunit signature 54 79 6.0E-17 T 17-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 PRINTS PR00124 ATP synthase C subunit signature 37 52 6.0E-17 T 17-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 SHXM_RS35235 927f808c5e346f81f7226c20f98dbf9b 80 PRINTS PR00124 ATP synthase C subunit signature 16 35 6.0E-17 T 17-03-2017 IPR000454 ATPase, F0 complex, subunit C GO:0015078|GO:0015986|GO:0045263 Reactome: R-HSA-163210 SHXM_RS42150 631bd1023a15972a3f8a645291711727 271 Gene3D G3DSA:3.40.50.300 12 245 1.0E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42150 631bd1023a15972a3f8a645291711727 271 SUPERFAMILY SSF52540 12 244 5.05E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS42150 631bd1023a15972a3f8a645291711727 271 SMART SM00382 37 242 4.8E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS42150 631bd1023a15972a3f8a645291711727 271 Pfam PF00005 ABC transporter 31 186 7.8E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 Gene3D G3DSA:3.40.190.10 189 246 1.5E-14 T 17-03-2017 SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 Gene3D G3DSA:1.10.10.10 2 85 1.8E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 Gene3D G3DSA:3.40.190.10 90 188 4.3E-18 T 17-03-2017 SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 Pfam PF03466 LysR substrate binding domain 89 286 7.3E-25 T 17-03-2017 IPR005119 LysR, substrate-binding SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 SUPERFAMILY SSF46785 1 110 9.73E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 SUPERFAMILY SSF53850 89 293 7.33E-24 T 17-03-2017 SHXM_RS46035 730f3516f9f8f317ad45d0e4a85d6f04 297 Pfam PF00126 Bacterial regulatory helix-turn-helix protein, lysR family 4 63 2.4E-14 T 17-03-2017 IPR000847 Transcription regulator HTH, LysR GO:0003700|GO:0006355 SHXM_RS09385 492ad68555ac364951a99e1e0ba59916 84 Pfam PF00392 Bacterial regulatory proteins, gntR family 20 83 4.4E-19 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09385 492ad68555ac364951a99e1e0ba59916 84 SUPERFAMILY SSF46785 16 84 5.84E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09385 492ad68555ac364951a99e1e0ba59916 84 Gene3D G3DSA:1.10.10.10 16 84 1.7E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09385 492ad68555ac364951a99e1e0ba59916 84 SMART SM00345 24 83 1.5E-18 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09385 492ad68555ac364951a99e1e0ba59916 84 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 57 73 8.8E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS09385 492ad68555ac364951a99e1e0ba59916 84 PRINTS PR00035 GntR bacterial regulatory protein HTH signature 43 57 8.8E-8 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS34170 40615456e4b364d80487a1bc7f4276b8 284 SMART SM00481 3 67 2.1E-14 T 17-03-2017 IPR003141 Polymerase/histidinol phosphatase, N-terminal GO:0003677|GO:0003887|GO:0006260 SHXM_RS34170 40615456e4b364d80487a1bc7f4276b8 284 Pfam PF02811 PHP domain 4 105 1.5E-9 T 17-03-2017 IPR004013 PHP domain GO:0003824 SHXM_RS34170 40615456e4b364d80487a1bc7f4276b8 284 Gene3D G3DSA:3.20.20.140 155 254 9.0E-36 T 17-03-2017 SHXM_RS34170 40615456e4b364d80487a1bc7f4276b8 284 Gene3D G3DSA:3.20.20.140 2 85 9.0E-36 T 17-03-2017 SHXM_RS34170 40615456e4b364d80487a1bc7f4276b8 284 SUPERFAMILY SSF89550 2 80 2.35E-43 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS34170 40615456e4b364d80487a1bc7f4276b8 284 SUPERFAMILY SSF89550 163 256 2.35E-43 T 17-03-2017 IPR016195 Polymerase/histidinol phosphatase-like GO:0003824 Reactome: R-HSA-6784531|Reactome: R-HSA-6791226 SHXM_RS49955 971f98657ccf403e9cf1fda22281ed36 161 SUPERFAMILY SSF102405 53 151 2.75E-5 T 17-03-2017 SHXM_RS49955 971f98657ccf403e9cf1fda22281ed36 161 Gene3D G3DSA:3.40.50.450 103 152 8.1E-6 T 17-03-2017 SHXM_RS32635 38029f6344ca47a10aaf14c3c53afdc0 454 Pfam PF01391 Collagen triple helix repeat (20 copies) 254 311 1.4E-9 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS32635 38029f6344ca47a10aaf14c3c53afdc0 454 Pfam PF01391 Collagen triple helix repeat (20 copies) 293 351 4.0E-8 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS32635 38029f6344ca47a10aaf14c3c53afdc0 454 Pfam PF11999 Protein of unknown function (DUF3494) 61 246 1.2E-65 T 17-03-2017 IPR021884 Protein of unknown function DUF3494 SHXM_RS45665 fa74ca92a8f0659427bd76d24f655104 209 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 35 124 3.9E-17 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS45665 fa74ca92a8f0659427bd76d24f655104 209 Gene3D G3DSA:2.30.110.10 26 153 3.5E-24 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS45665 fa74ca92a8f0659427bd76d24f655104 209 TIGRFAM TIGR04025 PPOX_FMN_DR2398: pyridoxamine 5'-phosphate oxidase, FMN-binding family 15 207 7.0E-69 T 17-03-2017 IPR024029 Pyridoxamine 5-phosphate oxidase, FMN-dependent SHXM_RS45665 fa74ca92a8f0659427bd76d24f655104 209 SUPERFAMILY SSF50475 35 155 2.18E-18 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18860 e3d3f4edd62948b41ce0156b6d482d85 476 Gene3D G3DSA:3.90.1150.10 430 455 6.7E-15 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS18860 e3d3f4edd62948b41ce0156b6d482d85 476 Gene3D G3DSA:3.90.1150.10 315 398 6.7E-15 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS18860 e3d3f4edd62948b41ce0156b6d482d85 476 Gene3D G3DSA:3.40.640.10 74 314 1.3E-65 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS18860 e3d3f4edd62948b41ce0156b6d482d85 476 SUPERFAMILY SSF53383 55 458 1.34E-83 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS18860 e3d3f4edd62948b41ce0156b6d482d85 476 Pfam PF00266 Aminotransferase class-V 58 448 7.8E-77 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS14180 4961274f0a665a7b9494e0ab30d9a4f5 496 SUPERFAMILY SSF52317 78 297 1.58E-51 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14180 4961274f0a665a7b9494e0ab30d9a4f5 496 Pfam PF06283 Trehalose utilisation 78 289 2.7E-87 T 17-03-2017 IPR029010 ThuA-like domain SHXM_RS14180 4961274f0a665a7b9494e0ab30d9a4f5 496 Pfam PF06439 Domain of Unknown Function (DUF1080) 302 480 2.6E-42 T 17-03-2017 IPR010496 Domain of unknown function DUF1080 SHXM_RS14180 4961274f0a665a7b9494e0ab30d9a4f5 496 Gene3D G3DSA:3.40.50.880 78 296 5.3E-43 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS14385 c68853c59fe18fbaa34a3f9540407a05 486 PIRSF PIRSF006060 1 449 8.5E-66 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS14385 c68853c59fe18fbaa34a3f9540407a05 486 Pfam PF13520 Amino acid permease 10 410 1.5E-49 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS19650 aa50293d436b1391039c0ce5f17d284c 429 Gene3D G3DSA:3.30.1540.10 254 336 4.8E-31 T 17-03-2017 SHXM_RS19650 aa50293d436b1391039c0ce5f17d284c 429 Gene3D G3DSA:3.40.50.10540 30 248 3.9E-111 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS19650 aa50293d436b1391039c0ce5f17d284c 429 Gene3D G3DSA:3.40.50.10540 337 429 3.9E-111 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS19650 aa50293d436b1391039c0ce5f17d284c 429 SUPERFAMILY SSF89796 31 429 1.44E-133 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS19650 aa50293d436b1391039c0ce5f17d284c 429 Pfam PF02515 CoA-transferase family III 34 406 5.1E-128 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS19375 10e72cb63a051210d71feadb3e0c3f3e 341 Gene3D G3DSA:3.60.10.10 125 277 1.5E-7 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS19375 10e72cb63a051210d71feadb3e0c3f3e 341 SUPERFAMILY SSF56219 125 340 3.01E-23 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS19375 10e72cb63a051210d71feadb3e0c3f3e 341 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 130 332 7.0E-17 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS17130 39c9c12f6ac9d91c5af101841be1c7f5 317 Hamap MF_00361 NAD kinase [nadK]. 24 307 29.382 T 17-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS17130 39c9c12f6ac9d91c5af101841be1c7f5 317 Pfam PF01513 ATP-NAD kinase 75 291 1.7E-55 T 17-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS17130 39c9c12f6ac9d91c5af101841be1c7f5 317 SUPERFAMILY SSF111331 25 313 2.88E-77 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS17130 39c9c12f6ac9d91c5af101841be1c7f5 317 Gene3D G3DSA:3.40.50.10330 24 165 3.4E-29 T 17-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS17130 39c9c12f6ac9d91c5af101841be1c7f5 317 Gene3D G3DSA:2.60.200.30 166 282 9.5E-38 T 17-03-2017 IPR017437 ATP-NAD kinase, PpnK-type, all-beta GO:0003951|GO:0008152|GO:0019674 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS20195 368db0badbd1a0aea050b880ea1f4411 395 SUPERFAMILY SSF51621 35 258 8.89E-25 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS20195 368db0badbd1a0aea050b880ea1f4411 395 SUPERFAMILY SSF51621 289 322 8.89E-25 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS20195 368db0badbd1a0aea050b880ea1f4411 395 Pfam PF15617 C-C_Bond_Lyase of the TIM-Barrel fold 31 378 1.4E-126 T 17-03-2017 SHXM_RS20195 368db0badbd1a0aea050b880ea1f4411 395 Gene3D G3DSA:3.20.20.60 36 322 2.9E-38 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS46085 22fdd0519398bafd0bf0c1852a6dbec1 322 Pfam PF05448 Acetyl xylan esterase (AXE1) 2 319 5.8E-104 T 17-03-2017 IPR008391 Acetyl xylan esterase SHXM_RS46085 22fdd0519398bafd0bf0c1852a6dbec1 322 Gene3D G3DSA:3.40.50.1820 2 321 1.1E-90 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46085 22fdd0519398bafd0bf0c1852a6dbec1 322 SUPERFAMILY SSF53474 156 305 7.14E-33 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS46085 22fdd0519398bafd0bf0c1852a6dbec1 322 SUPERFAMILY SSF53474 3 128 7.14E-33 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30935 fb65d2cd1f6930c5ccd61ca362ffa33d 603 Pfam PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit 68 207 7.8E-30 T 17-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30935 fb65d2cd1f6930c5ccd61ca362ffa33d 603 ProDom PD001581 OXIDOREDUCTASE SUBUNIT NADH DEHYDROGENASE CHAIN C NAD DEHYDROGENASE UBIQUINONE F420H2 140 195 5.0E-19 T 17-03-2017 IPR001268 NADH:ubiquinone oxidoreductase, 30kDa subunit GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30935 fb65d2cd1f6930c5ccd61ca362ffa33d 603 SUPERFAMILY SSF143243 59 214 1.44E-32 T 17-03-2017 SHXM_RS46360 8b28e3684d61659ba1cc35c6cb1f95bc 215 Gene3D G3DSA:1.10.3210.10 34 141 1.5E-9 T 17-03-2017 IPR006674 HD domain SHXM_RS46360 8b28e3684d61659ba1cc35c6cb1f95bc 215 Pfam PF01966 HD domain 35 122 1.4E-8 T 17-03-2017 IPR006674 HD domain SHXM_RS46360 8b28e3684d61659ba1cc35c6cb1f95bc 215 SUPERFAMILY SSF109604 32 139 4.19E-16 T 17-03-2017 SHXM_RS46965 06bef2fd870c888406f568d7c333bc4d 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 91 260 5.6E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46965 06bef2fd870c888406f568d7c333bc4d 275 Gene3D G3DSA:1.10.3720.10 5 260 4.3E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46965 06bef2fd870c888406f568d7c333bc4d 275 SUPERFAMILY SSF161098 4 274 7.85E-61 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19635 b65226c8d8c4e51ca4f705cf4b783db8 143 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 17 138 1.3E-32 T 17-03-2017 IPR018727 Protein of unknown function DUF2267 SHXM_RS47125 bcff3157e849d057d76cf1e0283a248d 354 Gene3D G3DSA:3.20.20.70 4 336 3.7E-69 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS47125 bcff3157e849d057d76cf1e0283a248d 354 SUPERFAMILY SSF51412 3 350 5.49E-60 T 17-03-2017 SHXM_RS47125 bcff3157e849d057d76cf1e0283a248d 354 Pfam PF03060 Nitronate monooxygenase 8 341 5.7E-93 T 17-03-2017 IPR004136 Nitronate monooxygenase GO:0018580|GO:0055114 KEGG: 00910+1.13.12.16|MetaCyc: PWY-723 SHXM_RS45980 0efd43f05bf7bb07ad8802279d099927 503 Pfam PF00696 Amino acid kinase family 3 232 6.8E-49 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS45980 0efd43f05bf7bb07ad8802279d099927 503 SUPERFAMILY SSF53633 4 245 2.23E-69 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS45980 0efd43f05bf7bb07ad8802279d099927 503 ProSitePatterns PS00324 Aspartokinase signature. 5 13 - T 17-03-2017 IPR018042 Aspartate kinase, conserved site GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS45980 0efd43f05bf7bb07ad8802279d099927 503 SUPERFAMILY SSF55021 337 411 5.72E-10 T 17-03-2017 SHXM_RS45980 0efd43f05bf7bb07ad8802279d099927 503 TIGRFAM TIGR00657 asp_kinases: aspartate kinase 63 410 4.6E-84 T 17-03-2017 IPR001341 Aspartate kinase domain GO:0004072|GO:0008652 KEGG: 00260+2.7.2.4|KEGG: 00261+2.7.2.4|KEGG: 00270+2.7.2.4|KEGG: 00300+2.7.2.4|MetaCyc: PWY-2941|MetaCyc: PWY-2942|MetaCyc: PWY-5097|MetaCyc: PWY-6559|MetaCyc: PWY-6562|MetaCyc: PWY-7153 SHXM_RS45980 0efd43f05bf7bb07ad8802279d099927 503 Gene3D G3DSA:3.40.1160.10 1 245 4.0E-68 T 17-03-2017 IPR001048 Aspartate/glutamate/uridylate kinase SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SUPERFAMILY SSF69318 107 310 6.71E-24 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SUPERFAMILY SSF69318 343 401 6.71E-24 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Pfam PF01839 FG-GAP repeat 109 127 5.0E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Pfam PF01839 FG-GAP repeat 450 478 1.4E-6 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Gene3D G3DSA:2.130.10.130 193 310 1.1E-24 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Gene3D G3DSA:2.130.10.130 345 496 1.1E-24 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Gene3D G3DSA:2.130.10.130 102 189 3.5E-11 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Gene3D G3DSA:2.130.10.130 510 585 5.5E-7 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SUPERFAMILY SSF69318 375 582 1.26E-17 T 17-03-2017 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SMART SM00191 446 502 0.23 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SMART SM00191 102 178 160.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SMART SM00191 365 435 180.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SMART SM00191 524 581 9.5 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 SMART SM00191 220 271 21.0 T 17-03-2017 IPR013519 Integrin alpha beta-propellor Reactome: R-HSA-216083 SHXM_RS20495 db2562a2656481783f08b184c62f8435 592 Pfam PF13517 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella 175 243 2.8E-7 T 17-03-2017 SHXM_RS04970 9dd0c35641e863b9d65e8a3033febe9b 1216 Pfam PF12770 CHAT domain 881 1204 2.1E-36 T 17-03-2017 IPR024983 CHAT domain SHXM_RS30875 5294fe45ca4c8a0560f09e1053e311ef 294 Pfam PF12679 ABC-2 family transporter protein 19 291 7.4E-14 T 17-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 SHXM_RS03500 7f96cc8502a1a34a1f560b898b485b2f 171 Gene3D G3DSA:2.60.120.10 45 163 6.2E-25 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS03500 7f96cc8502a1a34a1f560b898b485b2f 171 Pfam PF07883 Cupin domain 75 147 3.2E-8 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS03500 7f96cc8502a1a34a1f560b898b485b2f 171 SUPERFAMILY SSF51182 33 163 8.71E-21 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS10870 b867aff248ad8c6da795f86e4b9e8a8e 616 Gene3D G3DSA:1.50.10.10 282 534 1.6E-35 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS10870 b867aff248ad8c6da795f86e4b9e8a8e 616 SUPERFAMILY SSF48208 299 600 4.91E-42 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS10870 b867aff248ad8c6da795f86e4b9e8a8e 616 Pfam PF03663 Glycosyl hydrolase family 76 283 612 1.2E-42 T 17-03-2017 IPR005198 Glycoside hydrolase, family 76 KEGG: 00052+3.2.1.10|KEGG: 00500+3.2.1.10 SHXM_RS50745 4231a6e090e25a698832948225cc1b6b 235 Pfam PF13302 Acetyltransferase (GNAT) domain 137 225 7.1E-7 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS50745 4231a6e090e25a698832948225cc1b6b 235 SUPERFAMILY SSF55729 132 230 1.22E-8 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS50745 4231a6e090e25a698832948225cc1b6b 235 Gene3D G3DSA:3.40.630.30 140 229 3.8E-7 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS37390 4585940b808522a4065a919ae9663c79 173 Hamap MF_00440 Transcriptional repressor NrdR [nrdR]. 1 150 76.642 T 17-03-2017 IPR003796 Ribonucleotide reductase regulator NrdR-like GO:0008270|GO:0045892 SHXM_RS37390 4585940b808522a4065a919ae9663c79 173 TIGRFAM TIGR00244 TIGR00244: transcriptional regulator NrdR 1 144 2.2E-46 T 17-03-2017 IPR003796 Ribonucleotide reductase regulator NrdR-like GO:0008270|GO:0045892 SHXM_RS37390 4585940b808522a4065a919ae9663c79 173 Pfam PF03477 ATP cone domain 47 132 8.8E-14 T 17-03-2017 IPR005144 ATP-cone domain Reactome: R-HSA-499943 SHXM_RS38200 3ec4a36419b7a1f89264ad93096d9977 438 Pfam PF02653 Branched-chain amino acid transport system / permease component 102 422 1.0E-30 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS12935 4e1afcef2996d54896ecb8a7b0783a16 338 Pfam PF01758 Sodium Bile acid symporter family 68 244 2.5E-41 T 17-03-2017 IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3 GO:0016020 SHXM_RS50185 92c56302ab16254ee54a8378aaecb096 263 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 24 204 2.0E-50 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS50185 92c56302ab16254ee54a8378aaecb096 263 Gene3D G3DSA:3.40.225.10 18 229 3.9E-65 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS50185 92c56302ab16254ee54a8378aaecb096 263 SUPERFAMILY SSF53639 19 225 5.89E-65 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS50185 92c56302ab16254ee54a8378aaecb096 263 SMART SM01007 24 204 4.3E-67 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS40265 e1722f6e1484d3a8b57c6cab9f60c56c 93 Gene3D G3DSA:1.10.10.60 18 60 2.9E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS40265 e1722f6e1484d3a8b57c6cab9f60c56c 93 SUPERFAMILY SSF46689 18 62 4.31E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS40265 e1722f6e1484d3a8b57c6cab9f60c56c 93 Pfam PF00440 Bacterial regulatory proteins, tetR family 30 60 3.8E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS06840 7ad86259d365fff214ec7bd7fe0e25e1 275 TIGRFAM TIGR03619 F420_Rv2161c: probable F420-dependent oxidoreductase, Rv2161c family 19 251 1.1E-83 T 17-03-2017 IPR019921 Luciferase-like, F420-dependent oxidoreductase, Rv2161c, predicted SHXM_RS06840 7ad86259d365fff214ec7bd7fe0e25e1 275 SUPERFAMILY SSF51679 19 261 3.93E-63 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS06840 7ad86259d365fff214ec7bd7fe0e25e1 275 Gene3D G3DSA:3.20.20.30 19 231 3.8E-65 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS06840 7ad86259d365fff214ec7bd7fe0e25e1 275 Pfam PF00296 Luciferase-like monooxygenase 20 239 1.6E-54 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 SUPERFAMILY SSF51735 7 149 2.07E-34 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 Gene3D G3DSA:3.40.50.720 7 149 7.6E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 59 78 3.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 113 133 3.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 31 47 3.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 80 97 3.2E-14 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS09170 b0ed17b25fd75f266406c0be6d0b5fb0 149 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 6 149 2.2E-31 T 17-03-2017 SHXM_RS19545 a31853059126132383824611bd51df33 334 Gene3D G3DSA:3.40.710.10 4 314 2.3E-70 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS19545 a31853059126132383824611bd51df33 334 SUPERFAMILY SSF56601 38 317 9.49E-73 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS19545 a31853059126132383824611bd51df33 334 Pfam PF00144 Beta-lactamase 38 325 6.0E-64 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS10490 d13a58778aa533243dd9fc8d1fe1e13a 290 Hamap MF_01006 Undecaprenyl-diphosphatase [uppP]. 1 276 18.006 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS10490 d13a58778aa533243dd9fc8d1fe1e13a 290 TIGRFAM TIGR00753 undec_PP_bacA: undecaprenyl-diphosphatase UppP 7 269 1.4E-77 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS10490 d13a58778aa533243dd9fc8d1fe1e13a 290 Pfam PF02673 Bacitracin resistance protein BacA 7 271 1.0E-76 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS08685 2b838263496017aec5d6986cfc7b0df3 698 Pfam PF00916 Sulfate permease family 111 475 1.0E-54 T 17-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SHXM_RS39815 39fa50d0f4a7908cc686a959533fa4b8 98 SUPERFAMILY SSF56349 7 83 7.36E-7 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS39815 39fa50d0f4a7908cc686a959533fa4b8 98 Gene3D G3DSA:1.10.443.10 6 84 1.4E-8 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 Gene3D G3DSA:3.40.50.720 153 241 1.5E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 Pfam PF08240 Alcohol dehydrogenase GroES-like domain 28 89 9.5E-11 T 17-03-2017 IPR013154 Alcohol dehydrogenase, N-terminal GO:0055114 SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 Gene3D G3DSA:3.90.180.10 1 152 5.8E-48 T 17-03-2017 IPR011032 GroES-like SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 SMART SM00829 10 331 4.1E-25 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 Pfam PF13602 Zinc-binding dehydrogenase 187 331 1.7E-29 T 17-03-2017 SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 SUPERFAMILY SSF51735 117 244 1.42E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49140 c15b92f6cc22a314a9c94f4bb36cb14d 333 SUPERFAMILY SSF50129 1 150 2.43E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS04070 d7ae95f15ae6678eb819b120a71637a6 452 SUPERFAMILY SSF56601 19 344 4.88E-69 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS04070 d7ae95f15ae6678eb819b120a71637a6 452 Pfam PF00144 Beta-lactamase 23 338 1.7E-55 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS04070 d7ae95f15ae6678eb819b120a71637a6 452 Gene3D G3DSA:3.40.710.10 16 343 1.5E-71 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS02640 a8fd8607a70cc66a923912834d489732 365 Gene3D G3DSA:3.40.50.1820 12 335 9.7E-74 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02640 a8fd8607a70cc66a923912834d489732 365 SUPERFAMILY SSF53474 78 334 2.22E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02640 a8fd8607a70cc66a923912834d489732 365 Pfam PF07859 alpha/beta hydrolase fold 102 309 3.7E-50 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS30825 65a1eb0766c46c6cc1cfe9225025876e 342 SUPERFAMILY SSF53850 32 230 5.53E-22 T 17-03-2017 SHXM_RS30825 65a1eb0766c46c6cc1cfe9225025876e 342 Pfam PF09084 NMT1/THI5 like 130 212 2.1E-4 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS30825 65a1eb0766c46c6cc1cfe9225025876e 342 SUPERFAMILY SSF48371 258 340 4.32E-10 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS30825 65a1eb0766c46c6cc1cfe9225025876e 342 Gene3D G3DSA:1.25.10.10 248 340 1.3E-11 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS30825 65a1eb0766c46c6cc1cfe9225025876e 342 Pfam PF13646 HEAT repeats 258 340 1.3E-7 T 17-03-2017 SHXM_RS30825 65a1eb0766c46c6cc1cfe9225025876e 342 Gene3D G3DSA:3.40.190.10 137 225 8.6E-12 T 17-03-2017 SHXM_RS27410 53cb0fedefac885a9fae33c87b9e1262 432 Pfam PF00535 Glycosyl transferase family 2 34 201 1.3E-22 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS27410 53cb0fedefac885a9fae33c87b9e1262 432 SUPERFAMILY SSF53448 29 243 7.97E-35 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS27410 53cb0fedefac885a9fae33c87b9e1262 432 Pfam PF04138 GtrA-like protein 299 416 4.7E-14 T 17-03-2017 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 SHXM_RS27410 53cb0fedefac885a9fae33c87b9e1262 432 Gene3D G3DSA:3.90.550.10 33 242 4.5E-21 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS49970 b522ca53702dfda42a4838afb64cb566 323 SUPERFAMILY SSF103481 62 160 4.32E-7 T 17-03-2017 SHXM_RS49970 b522ca53702dfda42a4838afb64cb566 323 Pfam PF00892 EamA-like transporter family 22 159 2.5E-13 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS49970 b522ca53702dfda42a4838afb64cb566 323 Pfam PF00892 EamA-like transporter family 174 306 2.7E-15 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS49970 b522ca53702dfda42a4838afb64cb566 323 SUPERFAMILY SSF103481 207 311 3.4E-11 T 17-03-2017 SHXM_RS30170 39079e59115d158f8b664495bd35dbd1 382 Gene3D G3DSA:1.10.101.10 139 198 7.0E-12 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS30170 39079e59115d158f8b664495bd35dbd1 382 Pfam PF01471 Putative peptidoglycan binding domain 151 198 5.9E-11 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS30170 39079e59115d158f8b664495bd35dbd1 382 SUPERFAMILY SSF47090 140 199 3.14E-12 T 17-03-2017 IPR002477 Peptidoglycan binding-like SHXM_RS16795 a86fa121314a36afbbf4590b3a00005a 254 Pfam PF01925 Sulfite exporter TauE/SafE 12 250 9.4E-23 T 17-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 SHXM_RS07195 b1c6cec5d41e08afb506ba634f5ca9b8 245 PIRSF PIRSF006648 7 245 1.3E-24 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS07195 b1c6cec5d41e08afb506ba634f5ca9b8 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 172 191 1.9E-5 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS07195 b1c6cec5d41e08afb506ba634f5ca9b8 245 PRINTS PR00164 ABC-2 type transport system membrane protein signature 135 159 1.9E-5 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS07195 b1c6cec5d41e08afb506ba634f5ca9b8 245 Pfam PF01061 ABC-2 type transporter 11 212 2.2E-24 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS49755 7d55c9d1723f4a63aa19265e8e1c1959 216 Gene3D G3DSA:3.40.810.20 5 212 1.1E-90 T 17-03-2017 SHXM_RS49755 7d55c9d1723f4a63aa19265e8e1c1959 216 SMART SM00882 6 202 9.1E-75 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS49755 7d55c9d1723f4a63aa19265e8e1c1959 216 TIGRFAM TIGR02428 pcaJ_scoB_fam: 3-oxoacid CoA-transferase, B subunit 4 208 1.1E-95 T 17-03-2017 IPR012791 3-oxoacid CoA-transferase, subunit B GO:0008410 SHXM_RS49755 7d55c9d1723f4a63aa19265e8e1c1959 216 Pfam PF01144 Coenzyme A transferase 7 200 3.7E-42 T 17-03-2017 IPR004165 Coenzyme A transferase family I GO:0008152|GO:0008410 SHXM_RS49755 7d55c9d1723f4a63aa19265e8e1c1959 216 SUPERFAMILY SSF100950 5 213 1.3E-71 T 17-03-2017 SHXM_RS49755 7d55c9d1723f4a63aa19265e8e1c1959 216 ProSitePatterns PS01274 Coenzyme A transferases signature 2. 44 52 - T 17-03-2017 IPR004164 Coenzyme A transferase active site GO:0008152|GO:0008410 SHXM_RS10510 cd43726d628e83a9cb6faa61b70765ba 125 SUPERFAMILY SSF48008 7 79 1.46E-10 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS10510 cd43726d628e83a9cb6faa61b70765ba 125 Pfam PF07729 FCD domain 7 72 1.4E-9 T 17-03-2017 IPR011711 GntR, C-terminal SHXM_RS10510 cd43726d628e83a9cb6faa61b70765ba 125 Gene3D G3DSA:1.20.120.530 7 83 3.4E-9 T 17-03-2017 IPR008920 Transcription regulator FadR/GntR, C-terminal SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 Gene3D G3DSA:1.10.10.10 6 70 1.4E-17 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 SUPERFAMILY SSF46785 10 78 1.08E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 SUPERFAMILY SSF55781 82 255 1.24E-27 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 Pfam PF09339 IclR helix-turn-helix domain 12 61 5.4E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 Pfam PF01614 Bacterial transcriptional regulator 127 232 8.9E-17 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 SMART SM00346 10 98 1.1E-10 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS27245 338e5187e268297f13e67cef6f18f4c8 259 Gene3D G3DSA:3.30.450.40 84 255 2.0E-33 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS24900 542fdb85b47c5b52bcc92c0657632b87 283 Pfam PF13560 Helix-turn-helix domain 17 71 4.5E-12 T 17-03-2017 SHXM_RS24900 542fdb85b47c5b52bcc92c0657632b87 283 SUPERFAMILY SSF47413 14 68 4.29E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS24900 542fdb85b47c5b52bcc92c0657632b87 283 SMART SM00530 19 77 7.7E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS24900 542fdb85b47c5b52bcc92c0657632b87 283 Gene3D G3DSA:1.10.260.40 7 68 9.2E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06050 541dc43d431ce7159d6a647c9026df69 295 Pfam PF12911 N-terminal TM domain of oligopeptide transport permease C 19 48 4.8E-5 T 17-03-2017 IPR025966 Oligopeptide transport permease C-like, N-terminal domain SHXM_RS06050 541dc43d431ce7159d6a647c9026df69 295 Gene3D G3DSA:1.10.3720.10 28 277 1.1E-9 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06050 541dc43d431ce7159d6a647c9026df69 295 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 96 271 3.7E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06050 541dc43d431ce7159d6a647c9026df69 295 SUPERFAMILY SSF161098 73 260 1.57E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS01370 80ab722d5e2a8360dc49e5b0ad925b46 465 Pfam PF00083 Sugar (and other) transporter 58 445 4.4E-42 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS01370 80ab722d5e2a8360dc49e5b0ad925b46 465 Gene3D G3DSA:1.20.1250.20 264 445 2.2E-23 T 17-03-2017 SHXM_RS01370 80ab722d5e2a8360dc49e5b0ad925b46 465 Gene3D G3DSA:1.20.1250.20 17 199 1.3E-28 T 17-03-2017 SHXM_RS01370 80ab722d5e2a8360dc49e5b0ad925b46 465 ProSitePatterns PS00217 Sugar transport proteins signature 2. 117 142 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS01370 80ab722d5e2a8360dc49e5b0ad925b46 465 SUPERFAMILY SSF103473 10 445 5.49E-77 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 Pfam PF02056 Family 4 glycosyl hydrolase 5 182 2.2E-44 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 Gene3D G3DSA:3.40.50.720 2 164 5.1E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 Gene3D G3DSA:3.90.110.10 166 429 5.6E-63 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 Pfam PF11975 Family 4 glycosyl hydrolase C-terminal domain 194 406 6.6E-32 T 17-03-2017 IPR022616 Glycosyl hydrolase, family 4, C-terminal GO:0004553 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 PRINTS PR00732 Glycosyl hydrolase family 4 signature 74 90 1.5E-30 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 PRINTS PR00732 Glycosyl hydrolase family 4 signature 189 201 1.5E-30 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 PRINTS PR00732 Glycosyl hydrolase family 4 signature 5 20 1.5E-30 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 PRINTS PR00732 Glycosyl hydrolase family 4 signature 95 108 1.5E-30 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 PRINTS PR00732 Glycosyl hydrolase family 4 signature 109 129 1.5E-30 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 PRINTS PR00732 Glycosyl hydrolase family 4 signature 138 155 1.5E-30 T 17-03-2017 IPR001088 Glycoside hydrolase, family 4 GO:0004553|GO:0005975 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 SUPERFAMILY SSF56327 171 429 2.07E-44 T 17-03-2017 IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal GO:0003824|GO:0005975|GO:0016616|GO:0055114 SHXM_RS49570 2abe7da7e34a919d8aa95ad336764a2d 433 SUPERFAMILY SSF51735 4 165 3.94E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS23185 732990e6d4c6e6022414b925185b96e9 133 SUPERFAMILY SSF55874 38 126 1.24E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11325 da1c98ce9ae0dd0bc96ed7cf853989d6 287 SUPERFAMILY SSF47413 9 71 5.63E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11325 da1c98ce9ae0dd0bc96ed7cf853989d6 287 Gene3D G3DSA:1.10.260.40 7 71 6.6E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS11325 da1c98ce9ae0dd0bc96ed7cf853989d6 287 Pfam PF13560 Helix-turn-helix domain 13 74 7.2E-11 T 17-03-2017 SHXM_RS11325 da1c98ce9ae0dd0bc96ed7cf853989d6 287 SMART SM00530 17 73 9.7E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS20005 f36a996c33c418f92ea776d25ec94efe 657 SUPERFAMILY SSF51905 574 618 5.83E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20005 f36a996c33c418f92ea776d25ec94efe 657 SUPERFAMILY SSF51905 215 254 5.83E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20005 f36a996c33c418f92ea776d25ec94efe 657 SUPERFAMILY SSF51905 8 176 5.83E-8 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20005 f36a996c33c418f92ea776d25ec94efe 657 Pfam PF13454 FAD-NAD(P)-binding 9 175 2.3E-49 T 17-03-2017 SHXM_RS20005 f36a996c33c418f92ea776d25ec94efe 657 Gene3D G3DSA:3.50.50.60 8 177 7.1E-14 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS20005 f36a996c33c418f92ea776d25ec94efe 657 Gene3D G3DSA:3.50.50.60 576 615 7.1E-14 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS38180 fc0fbfe1c99a34ac6755aef160a8a59a 315 Gene3D G3DSA:1.10.3720.10 43 303 1.1E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38180 fc0fbfe1c99a34ac6755aef160a8a59a 315 SUPERFAMILY SSF161098 43 315 1.96E-70 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38180 fc0fbfe1c99a34ac6755aef160a8a59a 315 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 125 309 2.4E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27085 995f1a7c32c3561cc7a81b13b776baa4 142 Pfam PF09350 Domain of unknown function (DUF1992) 14 79 9.1E-22 T 17-03-2017 IPR018961 DnaJ homologue, subfamily C, member 28, conserved domain SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 SUPERFAMILY SSF47203 286 440 6.44E-40 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 ProSitePatterns PS00073 Acyl-CoA dehydrogenases signature 2. 396 415 - T 17-03-2017 IPR006089 Acyl-CoA dehydrogenase, conserved site GO:0003995|GO:0055114 SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 Gene3D G3DSA:1.20.140.10 272 440 4.7E-38 T 17-03-2017 SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 Gene3D G3DSA:2.40.110.10 177 271 4.6E-22 T 17-03-2017 SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 Pfam PF00441 Acyl-CoA dehydrogenase, C-terminal domain 281 437 2.5E-30 T 17-03-2017 IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal GO:0016627|GO:0055114 SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 Pfam PF02770 Acyl-CoA dehydrogenase, middle domain 177 270 2.1E-16 T 17-03-2017 IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain GO:0003995|GO:0055114 SHXM_RS07090 62f93179cc5080b0d5556c98a61d6e8a 548 SUPERFAMILY SSF56645 57 290 4.06E-38 T 17-03-2017 IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain GO:0008152|GO:0016627|GO:0055114 SHXM_RS10855 1a6ec0ad94612370032daac5c16f24b5 127 SUPERFAMILY SSF55874 24 121 8.84E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10855 1a6ec0ad94612370032daac5c16f24b5 127 Gene3D G3DSA:3.30.565.10 4 106 6.0E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10855 1a6ec0ad94612370032daac5c16f24b5 127 Pfam PF13581 Histidine kinase-like ATPase domain 3 99 1.4E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 Gene3D G3DSA:3.30.450.40 155 212 1.9E-6 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 SUPERFAMILY SSF46785 7 76 3.42E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 SUPERFAMILY SSF55781 67 212 4.86E-20 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 Pfam PF09339 IclR helix-turn-helix domain 8 58 2.8E-15 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 SMART SM00346 6 93 5.1E-16 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 Gene3D G3DSA:3.30.450.40 80 147 1.1E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS23570 37eeabd3d636f7209ac7d6ae43f4ea12 213 Gene3D G3DSA:1.10.10.10 5 76 7.6E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20895 1741e031268edd6017d813d7d59a7439 382 Gene3D G3DSA:3.40.640.10 26 272 2.3E-45 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS20895 1741e031268edd6017d813d7d59a7439 382 Pfam PF00266 Aminotransferase class-V 53 371 5.2E-24 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS20895 1741e031268edd6017d813d7d59a7439 382 SUPERFAMILY SSF53383 6 376 8.6E-60 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS32060 4fe216835540d9b12ed34d8700f24a39 98 Pfam PF08734 GYD domain 4 93 2.7E-31 T 17-03-2017 IPR014845 Uncharacterised protein GYD SHXM_RS48755 e7a6973e642a9360de5f9d3c4b29f731 198 Pfam PF09365 Conserved hypothetical protein (DUF2461) 53 189 2.0E-13 T 17-03-2017 IPR012808 Conserved hypothetical protein CHP02453 SHXM_RS02580 805733c21eb1726f32ba85064e828162 142 SUPERFAMILY SSF51182 24 131 2.97E-11 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS02580 805733c21eb1726f32ba85064e828162 142 Gene3D G3DSA:2.60.120.10 38 131 1.7E-11 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS00270 d2bb06db3682cfdf6f9c8519873d6b2c 229 Pfam PF07510 Protein of unknown function (DUF1524) 124 222 2.0E-9 T 17-03-2017 IPR011089 Domain of unknown function DUF1524 SHXM_RS36810 094c766c58b952a616f3186e5679d0a9 731 Gene3D G3DSA:3.40.50.300 523 657 1.0E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36810 094c766c58b952a616f3186e5679d0a9 731 Gene3D G3DSA:3.40.50.300 313 401 1.0E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36810 094c766c58b952a616f3186e5679d0a9 731 SUPERFAMILY SSF52540 309 651 2.45E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41415 936f79901235c1328587168d57c31b05 387 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 93 314 7.0E-25 T 17-03-2017 IPR018713 Domain of unknown function DUF2236 SHXM_RS50505 510486a955e8b1e7365f354dff453faa 553 Gene3D G3DSA:3.40.190.10 226 416 1.5E-29 T 17-03-2017 SHXM_RS50505 510486a955e8b1e7365f354dff453faa 553 Gene3D G3DSA:3.40.190.10 499 548 1.5E-29 T 17-03-2017 SHXM_RS50505 510486a955e8b1e7365f354dff453faa 553 Gene3D G3DSA:3.40.190.10 89 225 1.3E-17 T 17-03-2017 SHXM_RS50505 510486a955e8b1e7365f354dff453faa 553 Pfam PF13416 Bacterial extracellular solute-binding protein 113 414 7.8E-12 T 17-03-2017 SHXM_RS50505 510486a955e8b1e7365f354dff453faa 553 SUPERFAMILY SSF53850 90 548 1.02E-54 T 17-03-2017 SHXM_RS27880 6b3b55a86b92e3afe2a89df6ba4a2bff 191 SUPERFAMILY SSF55811 2 84 2.32E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27880 6b3b55a86b92e3afe2a89df6ba4a2bff 191 SUPERFAMILY SSF55811 115 144 2.32E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27880 6b3b55a86b92e3afe2a89df6ba4a2bff 191 Pfam PF00293 NUDIX domain 9 71 1.4E-11 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS27880 6b3b55a86b92e3afe2a89df6ba4a2bff 191 Gene3D G3DSA:3.90.79.10 3 82 4.1E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27880 6b3b55a86b92e3afe2a89df6ba4a2bff 191 Gene3D G3DSA:3.90.79.10 114 144 4.1E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS05265 44b16391b205701bee9c6c36ad64a082 496 Gene3D G3DSA:1.20.1250.20 23 200 9.0E-26 T 17-03-2017 SHXM_RS05265 44b16391b205701bee9c6c36ad64a082 496 Gene3D G3DSA:1.20.1250.20 270 485 1.4E-20 T 17-03-2017 SHXM_RS05265 44b16391b205701bee9c6c36ad64a082 496 Pfam PF07690 Major Facilitator Superfamily 27 420 6.7E-47 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS05265 44b16391b205701bee9c6c36ad64a082 496 SUPERFAMILY SSF103473 258 479 7.32E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05265 44b16391b205701bee9c6c36ad64a082 496 SUPERFAMILY SSF103473 8 202 7.32E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS45255 26bf692bdc5f2f45b9462b034b07bfda 233 Gene3D G3DSA:2.40.50.230 22 91 2.1E-20 T 17-03-2017 IPR006531 Gp5 N-terminal SHXM_RS45255 26bf692bdc5f2f45b9462b034b07bfda 233 SUPERFAMILY SSF69255 15 92 3.66E-20 T 17-03-2017 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 Pfam PF00072 Response regulator receiver domain 9 120 6.9E-27 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 Pfam PF00196 Bacterial regulatory proteins, luxR family 156 210 5.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 ProSitePatterns PS00622 LuxR-type HTH domain signature. 171 198 - T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 SMART SM00421 154 211 1.2E-20 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 SMART SM00448 7 120 3.0E-29 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 Gene3D G3DSA:3.40.50.2300 6 156 1.7E-38 T 17-03-2017 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 157 171 5.7E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 187 199 5.7E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 171 187 5.7E-11 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 SUPERFAMILY SSF46894 147 215 1.12E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 Gene3D G3DSA:1.10.10.10 157 214 1.1E-22 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28430 94df6b61b10ddaf2a7c9c076996b18a2 222 SUPERFAMILY SSF52172 6 136 2.99E-32 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS40800 0ad885c8af0999feeba1b7ccceebab91 336 PIRSF PIRSF006278 1 336 5.8E-123 T 17-03-2017 IPR027278 1-aminocyclopropane-1-carboxylate deaminase/D-cysteine desulfhydrase SHXM_RS40800 0ad885c8af0999feeba1b7ccceebab91 336 TIGRFAM TIGR01274 ACC_deam: 1-aminocyclopropane-1-carboxylate deaminase 3 335 2.1E-169 T 17-03-2017 IPR005965 1-aminocyclopropane-1-carboxylate deaminase GO:0008660|GO:0009310|GO:0030170 KEGG: 00270+3.5.99.7 SHXM_RS40800 0ad885c8af0999feeba1b7ccceebab91 336 SUPERFAMILY SSF53686 5 333 2.06E-98 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS40800 0ad885c8af0999feeba1b7ccceebab91 336 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 13 321 2.5E-48 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS40800 0ad885c8af0999feeba1b7ccceebab91 336 Gene3D G3DSA:3.40.50.1100 110 333 5.3E-76 T 17-03-2017 SHXM_RS37995 e65749a317ad8c89e26ab68230bfc768 341 Pfam PF00294 pfkB family carbohydrate kinase 12 305 4.6E-47 T 17-03-2017 IPR011611 Carbohydrate kinase PfkB SHXM_RS37995 e65749a317ad8c89e26ab68230bfc768 341 SUPERFAMILY SSF53613 12 314 5.51E-67 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS37995 e65749a317ad8c89e26ab68230bfc768 341 Gene3D G3DSA:3.40.1190.20 10 315 4.2E-82 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 133 153 1.9E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 84 99 1.9E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 PRINTS PR00598 Bacterial regulatory protein MarR family signature 103 119 1.9E-6 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 SMART SM00347 40 143 1.7E-15 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 SUPERFAMILY SSF46785 37 157 8.04E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 Pfam PF12802 MarR family 52 107 3.4E-11 T 17-03-2017 SHXM_RS05170 9448ff1329497c64c673e446121780f6 170 Gene3D G3DSA:1.10.10.10 25 157 6.4E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04145 d5f2f516bf4329cebc36b3161aae2476 620 Pfam PF10096 Uncharacterized protein conserved in bacteria (DUF2334) 338 605 2.0E-59 T 17-03-2017 IPR018763 Protein of unknown function DUF2334 SHXM_RS33570 6c58014ae7c54afe1327853f8e4997be 318 SUPERFAMILY SSF117892 124 252 1.11E-7 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS33570 6c58014ae7c54afe1327853f8e4997be 318 Pfam PF01145 SPFH domain / Band 7 family 90 259 3.7E-21 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS33570 6c58014ae7c54afe1327853f8e4997be 318 SMART SM00244 86 250 3.0E-7 T 17-03-2017 IPR001107 Band 7 domain SHXM_RS25640 1ca2bbebc436445be9545d007079372a 218 Gene3D G3DSA:1.10.10.10 159 209 2.1E-6 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25640 1ca2bbebc436445be9545d007079372a 218 Pfam PF04255 Protein of unknown function (DUF433) 161 209 3.9E-8 T 17-03-2017 IPR007367 Protein of unknown function DUF433 SHXM_RS25640 1ca2bbebc436445be9545d007079372a 218 SUPERFAMILY SSF46689 149 209 1.37E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS47245 54297f5ca0673bfd98035fe4d0e3088d 453 Gene3D G3DSA:3.40.190.10 48 121 4.7E-8 T 17-03-2017 SHXM_RS47245 54297f5ca0673bfd98035fe4d0e3088d 453 Pfam PF01547 Bacterial extracellular solute-binding protein 61 352 4.0E-36 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS47245 54297f5ca0673bfd98035fe4d0e3088d 453 SUPERFAMILY SSF53850 52 443 1.09E-66 T 17-03-2017 SHXM_RS47245 54297f5ca0673bfd98035fe4d0e3088d 453 Gene3D G3DSA:3.40.190.10 168 375 2.7E-38 T 17-03-2017 SHXM_RS49385 dbcebefa2de1a38ef842ba75a7cea2b5 71 Pfam PF09664 Protein of unknown function C-terminus (DUF2399) 4 60 5.0E-6 T 17-03-2017 IPR024465 Domain of unknown function DUF2399 SHXM_RS23435 260a529772f8abf2fde9ee686f5f8454 444 TIGRFAM TIGR01513 NAPRTase_put: nicotinate phosphoribosyltransferase 16 384 2.0E-128 T 17-03-2017 IPR006405 Nicotinate phosphoribosyltransferase pncB-type GO:0004516|GO:0019358 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 SHXM_RS23435 260a529772f8abf2fde9ee686f5f8454 444 SUPERFAMILY SSF54675 11 144 5.06E-44 T 17-03-2017 SHXM_RS23435 260a529772f8abf2fde9ee686f5f8454 444 PIRSF PIRSF000484 8 440 1.0E-103 T 17-03-2017 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 SHXM_RS23435 260a529772f8abf2fde9ee686f5f8454 444 Gene3D G3DSA:3.20.140.10 13 379 8.4E-91 T 17-03-2017 SHXM_RS23435 260a529772f8abf2fde9ee686f5f8454 444 SUPERFAMILY SSF51690 146 438 1.77E-78 T 17-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 SHXM_RS45580 728f664d614eaa3310a84b8b491a2343 179 Gene3D G3DSA:1.10.10.10 3 111 8.3E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45580 728f664d614eaa3310a84b8b491a2343 179 SUPERFAMILY SSF46785 7 142 1.01E-36 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS45580 728f664d614eaa3310a84b8b491a2343 179 Pfam PF01638 HxlR-like helix-turn-helix 21 107 1.4E-25 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS08780 ea562e7fd4db57f985288b0c53ef5e7d 619 SUPERFAMILY SSF52540 220 582 3.52E-37 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08780 ea562e7fd4db57f985288b0c53ef5e7d 619 Pfam PF12846 AAA-like domain 439 518 4.5E-7 T 17-03-2017 SHXM_RS08780 ea562e7fd4db57f985288b0c53ef5e7d 619 Gene3D G3DSA:3.40.50.300 417 585 2.6E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08780 ea562e7fd4db57f985288b0c53ef5e7d 619 Gene3D G3DSA:3.40.50.300 234 321 2.6E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08780 ea562e7fd4db57f985288b0c53ef5e7d 619 Pfam PF01935 Domain of unknown function DUF87 256 318 2.2E-5 T 17-03-2017 IPR002789 Helicase HerA, central domain SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 SUPERFAMILY SSF63380 2 91 7.82E-23 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 SUPERFAMILY SSF63380 96 199 1.28E-32 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 Pfam PF00677 Lumazine binding domain 3 89 1.6E-22 T 17-03-2017 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 Pfam PF00677 Lumazine binding domain 103 187 1.6E-22 T 17-03-2017 IPR026017 Lumazine-binding domain KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 TIGRFAM TIGR00187 ribE: riboflavin synthase, alpha subunit 2 202 1.2E-59 T 17-03-2017 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 Gene3D G3DSA:2.40.30.20 5 107 2.5E-32 T 17-03-2017 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 Gene3D G3DSA:2.40.30.20 108 199 3.5E-30 T 17-03-2017 IPR023366 ATP synthase subunit alpha-like domain KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219|Reactome: R-HSA-1268020|Reactome: R-HSA-163210 SHXM_RS12160 2b3048ea2397deb97b8bd168e2764029 230 PIRSF PIRSF000498 1 211 5.8E-69 T 17-03-2017 IPR001783 Lumazine-binding protein KEGG: 00740+2.5.1.9|MetaCyc: PWY-6167|MetaCyc: PWY-6168 SHXM_RS13840 5ac3b180862bcf1789328d0602d8e1fc 99 SUPERFAMILY SSF46785 3 55 6.82E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13840 5ac3b180862bcf1789328d0602d8e1fc 99 Pfam PF01638 HxlR-like helix-turn-helix 3 55 2.0E-15 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS13840 5ac3b180862bcf1789328d0602d8e1fc 99 Gene3D G3DSA:1.10.10.10 3 55 8.6E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS16495 13ab9244e1c0e94c395daa3ce3decac9 483 TIGRFAM TIGR00784 citMHS: citrate transporter 1 213 1.3E-82 T 17-03-2017 IPR014738 Citrate transporter GO:0015137|GO:0015746 SHXM_RS16495 13ab9244e1c0e94c395daa3ce3decac9 483 Pfam PF03600 Citrate transporter 14 431 3.8E-53 T 17-03-2017 IPR004680 Citrate transporter-like domain GO:0016021|GO:0055085 SHXM_RS28880 e3a43fc8e6ae4e93f629cd6c5c04ce75 241 Pfam PF05988 Bacterial protein of unknown function (DUF899) 1 219 6.1E-82 T 17-03-2017 IPR010296 Protein of unknown function DUF899, thioredoxin-like SHXM_RS28880 e3a43fc8e6ae4e93f629cd6c5c04ce75 241 SUPERFAMILY SSF52833 80 175 5.39E-5 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS32655 d63d94c1d2442c17472ccf58348eb42e 592 Pfam PF16192 C-terminal four TMM region of protein-O-mannosyltransferase 398 591 1.4E-23 T 17-03-2017 IPR032421 Protein O-mannosyl-transferase, C-terminal four TM domain KEGG: 00500+2.4.1.10|KEGG: 00514+2.4.1.109|MetaCyc: PWY-822|Reactome: R-HSA-5173105 SHXM_RS32655 d63d94c1d2442c17472ccf58348eb42e 592 Pfam PF02366 Dolichyl-phosphate-mannose-protein mannosyltransferase 82 305 4.8E-18 T 17-03-2017 IPR003342 Glycosyl transferase family 39/83 GO:0000030|GO:0006493|GO:0016020 Reactome: R-HSA-5173105 SHXM_RS21075 33efbb61817a65a24e27f953f098dd4f 197 Pfam PF01872 RibD C-terminal domain 2 173 1.0E-8 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS21075 33efbb61817a65a24e27f953f098dd4f 197 SUPERFAMILY SSF53597 2 193 2.23E-24 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS21075 33efbb61817a65a24e27f953f098dd4f 197 Gene3D G3DSA:3.40.430.10 3 194 1.2E-25 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS01775 524d935468739c1ab5cd3f07aa7111c0 432 SUPERFAMILY SSF51556 56 339 2.77E-58 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS01775 524d935468739c1ab5cd3f07aa7111c0 432 Gene3D G3DSA:3.20.20.140 72 356 5.1E-58 T 17-03-2017 SHXM_RS01775 524d935468739c1ab5cd3f07aa7111c0 432 Gene3D G3DSA:2.30.40.10 2 71 2.7E-22 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS01775 524d935468739c1ab5cd3f07aa7111c0 432 SUPERFAMILY SSF51338 339 408 5.5E-27 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS01775 524d935468739c1ab5cd3f07aa7111c0 432 SUPERFAMILY SSF51338 1 56 5.5E-27 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS01775 524d935468739c1ab5cd3f07aa7111c0 432 Pfam PF01979 Amidohydrolase family 53 388 7.8E-31 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS02465 79ad8034ee3654df83141ae15c0934ea 385 PIRSF PIRSF038971 6 379 5.5E-84 T 17-03-2017 IPR012696 Phosphonate metabolism PhnM GO:0019700 KEGG: 00440+3.6.1.63|MetaCyc: PWY-7399 SHXM_RS02465 79ad8034ee3654df83141ae15c0934ea 385 Gene3D G3DSA:2.30.40.10 318 370 1.2E-6 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS02465 79ad8034ee3654df83141ae15c0934ea 385 SUPERFAMILY SSF51556 204 347 1.02E-6 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS48020 1f78036f372e9acd69a2231b1bdfd57b 707 Gene3D G3DSA:3.20.20.70 343 458 4.6E-4 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS48020 1f78036f372e9acd69a2231b1bdfd57b 707 SUPERFAMILY SSF51445 317 438 1.1E-5 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS22790 817afabbc658e53a253d6c775bda9807 560 Gene3D G3DSA:1.20.810.10 30 451 1.5E-84 T 17-03-2017 IPR027387 Cytochrome b/b6-like domain Reactome: R-HSA-611105 SHXM_RS22790 817afabbc658e53a253d6c775bda9807 560 SUPERFAMILY SSF81342 30 307 1.11E-57 T 17-03-2017 IPR016174 Di-haem cytochrome, transmembrane GO:0016020|GO:0022904 Reactome: R-HSA-611105 SHXM_RS22790 817afabbc658e53a253d6c775bda9807 560 Pfam PF13631 Cytochrome b(N-terminal)/b6/petB 131 304 1.8E-54 T 17-03-2017 IPR005797 Cytochrome b/b6, N-terminal GO:0009055|GO:0016020|GO:0016491 Reactome: R-HSA-611105 SHXM_RS34605 72a6a8d90451beb2765dbe6e00fa1996 356 Gene3D G3DSA:3.40.50.10490 6 178 3.3E-31 T 17-03-2017 SHXM_RS34605 72a6a8d90451beb2765dbe6e00fa1996 356 Pfam PF01380 SIS domain 213 338 1.3E-15 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS34605 72a6a8d90451beb2765dbe6e00fa1996 356 Pfam PF01380 SIS domain 54 175 2.1E-16 T 17-03-2017 IPR001347 Sugar isomerase (SIS) GO:0005975|GO:0030246 SHXM_RS34605 72a6a8d90451beb2765dbe6e00fa1996 356 SUPERFAMILY SSF53697 17 354 9.75E-73 T 17-03-2017 SHXM_RS34605 72a6a8d90451beb2765dbe6e00fa1996 356 Gene3D G3DSA:3.40.50.10490 188 354 2.4E-41 T 17-03-2017 SHXM_RS14825 4c522f1c0cff075bfbadaacf0bf1d58a 1524 SUPERFAMILY SSF56112 960 1196 1.04E-7 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS14825 4c522f1c0cff075bfbadaacf0bf1d58a 1524 Gene3D G3DSA:3.40.50.300 1277 1489 1.6E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14825 4c522f1c0cff075bfbadaacf0bf1d58a 1524 SUPERFAMILY SSF52540 1277 1490 9.49E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS14825 4c522f1c0cff075bfbadaacf0bf1d58a 1524 SUPERFAMILY SSF56112 704 887 1.22E-7 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 Pfam PF00106 short chain dehydrogenase 8 181 2.8E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 123 131 3.9E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 70 81 3.9E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 141 160 3.9E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 Gene3D G3DSA:3.40.50.720 6 205 7.8E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 SUPERFAMILY SSF51735 5 204 1.53E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 162 179 1.1E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 1.1E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 117 133 1.1E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 141 160 1.1E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS45640 e2d98eb9ec30f7ddcdb73ce83baf940d 233 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 70 81 1.1E-20 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18740 f9d6a4d9cf70ebfd8c2c365c3e934bf4 449 TIGRFAM TIGR01358 DAHP_synth_II: 3-deoxy-7-phosphoheptulonate synthase 12 448 5.7E-233 T 17-03-2017 IPR002480 DAHP synthetase, class II GO:0003849|GO:0009073 KEGG: 00400+2.5.1.54|MetaCyc: PWY-6164 SHXM_RS18740 f9d6a4d9cf70ebfd8c2c365c3e934bf4 449 SUPERFAMILY SSF51569 11 447 2.64E-198 T 17-03-2017 SHXM_RS18740 f9d6a4d9cf70ebfd8c2c365c3e934bf4 449 Pfam PF01474 Class-II DAHP synthetase family 12 443 9.6E-201 T 17-03-2017 IPR002480 DAHP synthetase, class II GO:0003849|GO:0009073 KEGG: 00400+2.5.1.54|MetaCyc: PWY-6164 SHXM_RS27535 81eeaa0792046946553bde2367a8018e 149 ProDom PD004028 INHIBITOR PROTEASE SERINE DIRECT SEQUENCING SUBTILISIN PRECURSOR SIGNAL INHIBITOR-LIKE INHIBITOR 60 135 6.0E-10 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS27535 81eeaa0792046946553bde2367a8018e 149 Gene3D G3DSA:3.30.350.10 38 142 2.0E-33 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS27535 81eeaa0792046946553bde2367a8018e 149 SUPERFAMILY SSF55399 43 141 5.23E-27 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS27535 81eeaa0792046946553bde2367a8018e 149 ProSitePatterns PS00999 Streptomyces subtilisin-type inhibitors signature. 64 81 - T 17-03-2017 IPR020054 Proteinase inhibitor I16, Streptomyces subtilisin-type inhibitor, conserved site GO:0004867 SHXM_RS27535 81eeaa0792046946553bde2367a8018e 149 Pfam PF00720 Subtilisin inhibitor-like 43 123 1.7E-13 T 17-03-2017 IPR023549 Subtilisin inhibitor GO:0004867 SHXM_RS40695 0a60df52fd8f0efc29e92d9ff4b7f976 281 Pfam PF12706 Beta-lactamase superfamily domain 37 247 5.6E-17 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS40695 0a60df52fd8f0efc29e92d9ff4b7f976 281 Gene3D G3DSA:3.60.15.10 3 280 3.0E-51 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS40695 0a60df52fd8f0efc29e92d9ff4b7f976 281 SUPERFAMILY SSF56281 5 280 3.93E-49 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS00735 6ba83b0d00fe0af3b41de42468c9ec2a 686 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 5 183 2.4E-42 T 17-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS00735 6ba83b0d00fe0af3b41de42468c9ec2a 686 Pfam PF01968 Hydantoinase/oxoprolinase 205 489 2.9E-88 T 17-03-2017 IPR002821 Hydantoinase/oxoprolinase GO:0016787 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 ProSitePatterns PS00445 FGGY family of carbohydrate kinases signature 2. 367 387 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 TIGRFAM TIGR01311 glycerol_kin: glycerol kinase 4 501 4.3E-220 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 SUPERFAMILY SSF53067 259 502 7.38E-85 T 17-03-2017 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 Pfam PF02782 FGGY family of carbohydrate kinases, C-terminal domain 265 455 2.1E-66 T 17-03-2017 IPR018485 Carbohydrate kinase, FGGY, C-terminal GO:0005975|GO:0016773 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 Gene3D G3DSA:3.30.420.40 259 502 4.9E-103 T 17-03-2017 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 ProSitePatterns PS00933 FGGY family of carbohydrate kinases signature 1. 134 146 - T 17-03-2017 IPR018483 Carbohydrate kinase, FGGY, conserved site GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 Hamap MF_00186 Glycerol kinase [glpK]. 2 502 54.43 T 17-03-2017 IPR005999 Glycerol kinase GO:0004370|GO:0006072 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261|Reactome: R-HSA-75109 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 Gene3D G3DSA:3.30.420.40 3 257 8.9E-95 T 17-03-2017 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 PIRSF PIRSF000538 3 505 4.5E-155 T 17-03-2017 IPR000577 Carbohydrate kinase, FGGY GO:0005975|GO:0016773 KEGG: 00561+2.7.1.30|MetaCyc: PWY-4261 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 SUPERFAMILY SSF53067 4 259 8.19E-82 T 17-03-2017 SHXM_RS07965 9a7543ea6de879677f8053e84bf55c9e 505 Pfam PF00370 FGGY family of carbohydrate kinases, N-terminal domain 5 256 3.5E-69 T 17-03-2017 IPR018484 Carbohydrate kinase, FGGY, N-terminal GO:0005975|GO:0016773 SHXM_RS07315 14373480ac7c45690240affbabd432a2 253 Pfam PF02571 Precorrin-6x reductase CbiJ/CobK 9 248 6.4E-71 T 17-03-2017 IPR003723 Precorrin-6x reductase GO:0009236|GO:0016994|GO:0055114 SHXM_RS07315 14373480ac7c45690240affbabd432a2 253 TIGRFAM TIGR00715 precor6x_red: precorrin-6x reductase 9 248 1.1E-46 T 17-03-2017 IPR003723 Precorrin-6x reductase GO:0009236|GO:0016994|GO:0055114 SHXM_RS07315 14373480ac7c45690240affbabd432a2 253 Gene3D G3DSA:3.40.50.2300 189 247 3.4E-5 T 17-03-2017 SHXM_RS02425 4ec3d874f5d81bc671481a3590a1b65e 308 SUPERFAMILY SSF56281 53 288 7.99E-33 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02425 4ec3d874f5d81bc671481a3590a1b65e 308 Pfam PF00753 Metallo-beta-lactamase superfamily 67 280 9.7E-28 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02425 4ec3d874f5d81bc671481a3590a1b65e 308 SMART SM00849 65 280 3.3E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS02425 4ec3d874f5d81bc671481a3590a1b65e 308 Gene3D G3DSA:3.60.15.10 6 293 2.2E-39 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS27970 985a275573f9c4b91d55c6864c8b2e50 446 TIGRFAM TIGR00797 matE: MATE efflux family protein 25 415 1.9E-99 T 17-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 SHXM_RS27970 985a275573f9c4b91d55c6864c8b2e50 446 Pfam PF01554 MatE 25 184 8.5E-27 T 17-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 SHXM_RS27970 985a275573f9c4b91d55c6864c8b2e50 446 Pfam PF01554 MatE 243 394 7.6E-21 T 17-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 SHXM_RS27970 985a275573f9c4b91d55c6864c8b2e50 446 PIRSF PIRSF006603 7 445 4.6E-59 T 17-03-2017 IPR002528 Multi antimicrobial extrusion protein GO:0006855|GO:0015238|GO:0015297|GO:0016020|GO:0055085 Reactome: R-HSA-425366 SHXM_RS42455 44c5b711956469adfb8b82130fdb6171 268 SUPERFAMILY SSF160104 17 260 3.92E-48 T 17-03-2017 SHXM_RS42455 44c5b711956469adfb8b82130fdb6171 268 Gene3D G3DSA:2.40.400.10 17 260 5.2E-43 T 17-03-2017 IPR023375 Acetoacetate decarboxylase beta barrel domain KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 SHXM_RS42455 44c5b711956469adfb8b82130fdb6171 268 Pfam PF06314 Acetoacetate decarboxylase (ADC) 13 261 9.5E-57 T 17-03-2017 IPR010451 Acetoacetate decarboxylase GO:0016829 KEGG: 00072+4.1.1.4|KEGG: 00640+4.1.1.4|MetaCyc: PWY-5451|MetaCyc: PWY-6588|MetaCyc: PWY-6876|MetaCyc: PWY-7466 SHXM_RS00665 b52d6c28020431b17c7b3a59542fae1f 125 SUPERFAMILY SSF54427 1 116 1.02E-12 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS00665 b52d6c28020431b17c7b3a59542fae1f 125 Pfam PF12680 SnoaL-like domain 11 110 2.3E-7 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS00665 b52d6c28020431b17c7b3a59542fae1f 125 Gene3D G3DSA:3.10.450.50 2 117 5.8E-10 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS36970 0b940e2cb7fa1c5ba3ec521384e9e3e0 388 TIGRFAM TIGR03923 T7SS_EccE: type VII secretion protein EccE 2 388 2.3E-64 T 17-03-2017 IPR021368 Type VII secretion system protein EccE SHXM_RS36970 0b940e2cb7fa1c5ba3ec521384e9e3e0 388 Pfam PF11203 Putative type VII ESX secretion system translocon, EccE 179 287 8.4E-26 T 17-03-2017 IPR021368 Type VII secretion system protein EccE SHXM_RS15835 fa42bc449e2ec64c3da4137d7ae56a86 293 SUPERFAMILY SSF63380 8 131 5.73E-14 T 17-03-2017 IPR017938 Riboflavin synthase-like beta-barrel GO:0016491|GO:0055114 SHXM_RS15835 fa42bc449e2ec64c3da4137d7ae56a86 293 Pfam PF08021 Siderophore-interacting FAD-binding domain 16 131 9.4E-40 T 17-03-2017 IPR013113 FAD-binding 9, siderophore-interacting SHXM_RS15835 fa42bc449e2ec64c3da4137d7ae56a86 293 Gene3D G3DSA:2.40.30.10 8 130 6.1E-37 T 17-03-2017 SHXM_RS15835 fa42bc449e2ec64c3da4137d7ae56a86 293 Gene3D G3DSA:3.40.50.80 133 283 5.3E-52 T 17-03-2017 SHXM_RS15835 fa42bc449e2ec64c3da4137d7ae56a86 293 Pfam PF04954 Siderophore-interacting protein 138 262 3.2E-37 T 17-03-2017 IPR007037 Siderophore-interacting protein SHXM_RS37660 d2986f1a47ec0f27f649a930dbce46ce 270 PIRSF PIRSF010219 4 231 1.8E-78 T 17-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 SHXM_RS37660 d2986f1a47ec0f27f649a930dbce46ce 270 Pfam PF11361 Protein of unknown function (DUF3159) 31 217 1.2E-58 T 17-03-2017 IPR016566 Uncharacterised conserved protein UCP010219 SHXM_RS09855 d073c1a6c4aeadec7d6c825866acbb6b 91 Pfam PF13683 Integrase core domain 6 36 1.5E-7 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS09855 d073c1a6c4aeadec7d6c825866acbb6b 91 SUPERFAMILY SSF53098 7 44 4.36E-5 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS00310 df7311bbd8f81ede6465cb1f09cd1e68 199 SUPERFAMILY SSF88659 128 184 1.26E-10 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00310 df7311bbd8f81ede6465cb1f09cd1e68 199 Gene3D G3DSA:1.10.10.10 130 185 6.5E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS00310 df7311bbd8f81ede6465cb1f09cd1e68 199 Pfam PF08281 Sigma-70, region 4 130 180 8.2E-12 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00310 df7311bbd8f81ede6465cb1f09cd1e68 199 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 30 184 8.6E-13 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS00310 df7311bbd8f81ede6465cb1f09cd1e68 199 Gene3D G3DSA:1.10.1740.10 29 89 3.1E-4 T 17-03-2017 SHXM_RS27765 71b03efb8c80f58c9f58f7497c500fde 302 Gene3D G3DSA:3.20.20.30 17 294 2.7E-61 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS27765 71b03efb8c80f58c9f58f7497c500fde 302 SUPERFAMILY SSF51679 14 281 1.18E-54 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS27765 71b03efb8c80f58c9f58f7497c500fde 302 Pfam PF00296 Luciferase-like monooxygenase 18 238 3.7E-45 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS18150 695ad70d0ce488ce24a8fcf586039025 410 Pfam PF13458 Periplasmic binding protein 40 398 6.3E-45 T 17-03-2017 IPR028081 Leucine-binding protein domain SHXM_RS18150 695ad70d0ce488ce24a8fcf586039025 410 SUPERFAMILY SSF53822 40 403 4.37E-72 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS18150 695ad70d0ce488ce24a8fcf586039025 410 Gene3D G3DSA:3.40.50.2300 40 250 3.2E-50 T 17-03-2017 SHXM_RS42480 1ce350b89d9058c866cb1cc57151abee 191 Gene3D G3DSA:1.10.10.10 25 167 1.2E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42480 1ce350b89d9058c866cb1cc57151abee 191 SUPERFAMILY SSF46785 28 167 3.98E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42480 1ce350b89d9058c866cb1cc57151abee 191 SMART SM00347 49 149 1.2E-19 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS42480 1ce350b89d9058c866cb1cc57151abee 191 Pfam PF01047 MarR family 56 114 3.4E-9 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS09150 df6afde59c7c8ccf6acb658266af01cc 192 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 13 178 3.2E-15 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS09150 df6afde59c7c8ccf6acb658266af01cc 192 SUPERFAMILY SSF56219 13 186 1.57E-22 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS09150 df6afde59c7c8ccf6acb658266af01cc 192 Gene3D G3DSA:3.60.10.10 13 186 5.3E-9 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS12350 d3cd928ee625e0515f0415c476537de9 367 Gene3D G3DSA:3.20.20.70 1 363 6.7E-130 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS12350 d3cd928ee625e0515f0415c476537de9 367 Pfam PF01180 Dihydroorotate dehydrogenase 50 348 1.1E-94 T 17-03-2017 IPR005720 Dihydroorotate dehydrogenase domain GO:0005737|GO:0016627|GO:0055114 SHXM_RS12350 d3cd928ee625e0515f0415c476537de9 367 Hamap MF_00225 Dihydroorotate dehydrogenase (quinone) [pyrD]. 1 344 47.182 T 17-03-2017 IPR005719 Dihydroorotate dehydrogenase, class 2 GO:0004152|GO:0006207|GO:0016020|GO:0055114 KEGG: 00240+1.3.5.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12350 d3cd928ee625e0515f0415c476537de9 367 SUPERFAMILY SSF51395 1 363 2.26E-103 T 17-03-2017 SHXM_RS12350 d3cd928ee625e0515f0415c476537de9 367 TIGRFAM TIGR01036 pyrD_sub2: dihydroorotate dehydrogenase (fumarate) 4 363 3.1E-127 T 17-03-2017 IPR005719 Dihydroorotate dehydrogenase, class 2 GO:0004152|GO:0006207|GO:0016020|GO:0055114 KEGG: 00240+1.3.5.2|MetaCyc: PWY-5686|Reactome: R-HSA-500753 SHXM_RS12350 d3cd928ee625e0515f0415c476537de9 367 ProSitePatterns PS00912 Dihydroorotate dehydrogenase signature 2. 300 320 - T 17-03-2017 IPR001295 Dihydroorotate dehydrogenase, conserved site GO:0004152|GO:0006207|GO:0055114 Reactome: R-HSA-500753 SHXM_RS21100 b7c13f7094eab2682afb704d00d022d5 283 Pfam PF13560 Helix-turn-helix domain 13 71 8.5E-10 T 17-03-2017 SHXM_RS21100 b7c13f7094eab2682afb704d00d022d5 283 Gene3D G3DSA:1.10.260.40 7 68 9.3E-10 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS21100 b7c13f7094eab2682afb704d00d022d5 283 SUPERFAMILY SSF47413 10 71 1.31E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS21100 b7c13f7094eab2682afb704d00d022d5 283 SMART SM00530 17 72 6.7E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS20985 bb57ad6b632f431d09c1017190b1a826 457 SUPERFAMILY SSF103473 246 451 4.97E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20985 bb57ad6b632f431d09c1017190b1a826 457 SUPERFAMILY SSF103473 4 195 4.97E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20985 bb57ad6b632f431d09c1017190b1a826 457 Gene3D G3DSA:1.20.1250.20 6 192 5.7E-31 T 17-03-2017 SHXM_RS20985 bb57ad6b632f431d09c1017190b1a826 457 Gene3D G3DSA:1.20.1250.20 276 448 1.5E-11 T 17-03-2017 SHXM_RS20985 bb57ad6b632f431d09c1017190b1a826 457 Pfam PF07690 Major Facilitator Superfamily 10 410 1.3E-44 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS02170 7e59e296b338d74524ccaf3f747c5fe2 335 TIGRFAM TIGR03944 dehyd_SbnB_fam: 2,3-diaminopropionate biosynthesis protein SbnB 5 328 8.7E-127 T 17-03-2017 IPR023866 2,3-diaminopropionate biosynthesis protein SbnB SHXM_RS02170 7e59e296b338d74524ccaf3f747c5fe2 335 Gene3D G3DSA:3.40.50.720 145 292 1.9E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02170 7e59e296b338d74524ccaf3f747c5fe2 335 Gene3D G3DSA:3.30.1780.10 4 144 1.7E-36 T 17-03-2017 IPR023401 Ornithine cyclodeaminase, N-terminal Reactome: R-HSA-71064 SHXM_RS02170 7e59e296b338d74524ccaf3f747c5fe2 335 SUPERFAMILY SSF51735 4 326 3.13E-66 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS02170 7e59e296b338d74524ccaf3f747c5fe2 335 Pfam PF02423 Ornithine cyclodeaminase/mu-crystallin family 24 318 5.7E-35 T 17-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 SHXM_RS02170 7e59e296b338d74524ccaf3f747c5fe2 335 PIRSF PIRSF001439 1 328 1.2E-65 T 17-03-2017 IPR003462 Ornithine cyclodeaminase/mu-crystallin Reactome: R-HSA-71064 SHXM_RS00215 9f3e46e25d674068536842fc78e79f16 1040 Pfam PF01526 Tn3 transposase DDE domain 618 1015 3.9E-134 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS00215 9f3e46e25d674068536842fc78e79f16 1040 Pfam PF13700 Domain of unknown function (DUF4158) 5 174 5.3E-49 T 17-03-2017 IPR025296 Domain of unknown function DUF4158 SHXM_RS01230 689b6f6c6cb33b271e223c402b12a036 291 SUPERFAMILY SSF56112 25 271 8.28E-32 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS01230 689b6f6c6cb33b271e223c402b12a036 291 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 33 263 2.0E-21 T 17-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 SHXM_RS01230 689b6f6c6cb33b271e223c402b12a036 291 Gene3D G3DSA:3.90.1200.10 117 233 2.7E-10 T 17-03-2017 SHXM_RS45505 03deab3328bdc09f9e006e0ee6ef53ff 334 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 131 227 3.1E-7 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS45505 03deab3328bdc09f9e006e0ee6ef53ff 334 SUPERFAMILY SSF51735 2 147 3.95E-40 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45505 03deab3328bdc09f9e006e0ee6ef53ff 334 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 1 118 1.9E-21 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS45505 03deab3328bdc09f9e006e0ee6ef53ff 334 Gene3D G3DSA:3.30.360.10 130 329 3.4E-49 T 17-03-2017 SHXM_RS45505 03deab3328bdc09f9e006e0ee6ef53ff 334 SUPERFAMILY SSF55347 123 277 8.83E-26 T 17-03-2017 SHXM_RS45505 03deab3328bdc09f9e006e0ee6ef53ff 334 Gene3D G3DSA:3.40.50.720 1 129 5.3E-36 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 SMART SM00939 294 520 3.2E-67 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 SUPERFAMILY SSF49785 294 524 7.86E-51 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 SUPERFAMILY SSF53474 9 341 4.78E-69 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 TIGRFAM TIGR00976 /NonD: hydrolase CocE/NonD family protein 19 355 4.3E-50 T 17-03-2017 IPR005674 CocE/Serine esterase GO:0016787 SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 Pfam PF02129 X-Pro dipeptidyl-peptidase (S15 family) 22 276 1.6E-67 T 17-03-2017 IPR000383 Xaa-Pro dipeptidyl-peptidase-like domain GO:0016787 SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 Gene3D G3DSA:3.40.50.1820 220 335 5.5E-76 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 Gene3D G3DSA:3.40.50.1820 8 159 5.5E-76 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 Pfam PF08530 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain 307 517 2.6E-42 T 17-03-2017 IPR013736 Xaa-Pro dipeptidyl-peptidase, C-terminal GO:0008239 SHXM_RS33305 0eb65b8215ba5bd7ad528cc574f5c995 670 Gene3D G3DSA:2.60.120.260 338 528 9.9E-51 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 Gene3D G3DSA:3.40.50.720 22 278 1.4E-54 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 176 204 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 Pfam PF00106 short chain dehydrogenase 30 232 7.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 104 115 3.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 156 164 3.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 189 208 3.5E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 166 1.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 29 46 1.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 189 208 1.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 104 115 1.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 227 1.0E-18 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47505 07e54d8ab221f4228f4c3c1b8828f9c4 318 SUPERFAMILY SSF51735 25 282 1.88E-51 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS17680 d826f24a221f15065ce0f360597105bf 170 Gene3D G3DSA:3.40.50.300 8 122 4.6E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17680 d826f24a221f15065ce0f360597105bf 170 SUPERFAMILY SSF52540 9 154 1.42E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37135 ca12342c01704aa67d16ef7531b93c2d 232 SUPERFAMILY SSF53383 14 222 3.06E-37 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS37135 ca12342c01704aa67d16ef7531b93c2d 232 Gene3D G3DSA:3.90.1150.10 111 224 9.2E-24 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS37135 ca12342c01704aa67d16ef7531b93c2d 232 Gene3D G3DSA:3.40.640.10 14 99 6.8E-26 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS37135 ca12342c01704aa67d16ef7531b93c2d 232 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 5 99 6.1E-29 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS37135 ca12342c01704aa67d16ef7531b93c2d 232 Pfam PF01041 DegT/DnrJ/EryC1/StrS aminotransferase family 111 220 1.3E-11 T 17-03-2017 IPR000653 DegT/DnrJ/EryC1/StrS aminotransferase SHXM_RS39945 f0c905b34f0184f0fc22d5e3e6d98ce3 155 Pfam PF12802 MarR family 41 93 1.3E-10 T 17-03-2017 SHXM_RS39945 f0c905b34f0184f0fc22d5e3e6d98ce3 155 Gene3D G3DSA:1.10.10.10 36 139 2.4E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS39945 f0c905b34f0184f0fc22d5e3e6d98ce3 155 SMART SM00347 30 129 3.5E-7 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS39945 f0c905b34f0184f0fc22d5e3e6d98ce3 155 SUPERFAMILY SSF46785 23 139 4.76E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS07175 cd375d8a5e6c42977ebba403d4b50f68 328 Gene3D G3DSA:3.20.20.100 1 313 7.1E-92 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS07175 cd375d8a5e6c42977ebba403d4b50f68 328 Pfam PF00248 Aldo/keto reductase family 16 312 7.0E-69 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS07175 cd375d8a5e6c42977ebba403d4b50f68 328 SUPERFAMILY SSF51430 1 315 4.06E-95 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS17835 7f25bc8e7b3a46f2dfb7cfdb92768fbe 266 Pfam PF12802 MarR family 35 78 6.1E-7 T 17-03-2017 SHXM_RS17835 7f25bc8e7b3a46f2dfb7cfdb92768fbe 266 Gene3D G3DSA:1.10.10.10 31 120 1.0E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17835 7f25bc8e7b3a46f2dfb7cfdb92768fbe 266 SUPERFAMILY SSF46785 30 220 1.31E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS01340 21108512a759909be9bb82c49119e9dc 288 Gene3D G3DSA:3.40.50.1820 28 283 1.2E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01340 21108512a759909be9bb82c49119e9dc 288 Pfam PF12697 Alpha/beta hydrolase family 51 278 7.5E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01340 21108512a759909be9bb82c49119e9dc 288 SUPERFAMILY SSF53474 25 284 3.11E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS31450 1221db17c9dbe3c42fb670405e80496b 222 TIGRFAM TIGR03725 T6A_YeaZ: tRNA threonylcarbamoyl adenosine modification protein YeaZ 3 206 5.9E-57 T 17-03-2017 IPR022496 tRNA threonylcarbamoyl adenosine modification protein YeaZ GO:0002949 SHXM_RS31450 1221db17c9dbe3c42fb670405e80496b 222 Gene3D G3DSA:3.30.420.40 2 130 5.8E-36 T 17-03-2017 SHXM_RS31450 1221db17c9dbe3c42fb670405e80496b 222 SUPERFAMILY SSF53067 110 204 2.59E-11 T 17-03-2017 SHXM_RS31450 1221db17c9dbe3c42fb670405e80496b 222 Pfam PF00814 Glycoprotease family 32 147 9.3E-29 T 17-03-2017 IPR000905 Gcp-like domain KEGG: 00564+2.3.1.23|MetaCyc: PWY-5353|MetaCyc: PWY-5368|MetaCyc: PWY-5995|MetaCyc: PWY-6433|MetaCyc: PWY-6803|MetaCyc: PWY-6958|MetaCyc: PWY-7409|MetaCyc: PWY-7416|MetaCyc: PWY-7470|MetaCyc: PWY-7618 SHXM_RS31450 1221db17c9dbe3c42fb670405e80496b 222 SUPERFAMILY SSF53067 3 103 3.11E-21 T 17-03-2017 SHXM_RS45450 0ecdb68e924e0ef77886ceb519264d99 267 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 137 157 - T 17-03-2017 IPR001110 Uncharacterised protein family UPF0012, conserved site SHXM_RS45450 0ecdb68e924e0ef77886ceb519264d99 267 SUPERFAMILY SSF56317 1 256 1.11E-66 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS45450 0ecdb68e924e0ef77886ceb519264d99 267 Gene3D G3DSA:3.60.110.10 1 257 4.7E-68 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS45450 0ecdb68e924e0ef77886ceb519264d99 267 Pfam PF00795 Carbon-nitrogen hydrolase 9 242 4.9E-43 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS34290 164f9ba69b11c2facb4247a7ab7f45f7 311 Pfam PF09296 NADH pyrophosphatase-like rudimentary NUDIX domain 43 137 4.5E-13 T 17-03-2017 IPR015375 NADH pyrophosphatase-like, N-terminal GO:0016787 KEGG: 00760+3.6.1.22|MetaCyc: PWY-5381 SHXM_RS34290 164f9ba69b11c2facb4247a7ab7f45f7 311 Pfam PF09297 NADH pyrophosphatase zinc ribbon domain 140 170 1.2E-13 T 17-03-2017 IPR015376 Zinc ribbon, NADH pyrophosphatase GO:0016787|GO:0046872 KEGG: 00760+3.6.1.22|MetaCyc: PWY-5381 SHXM_RS34290 164f9ba69b11c2facb4247a7ab7f45f7 311 Pfam PF00293 NUDIX domain 174 286 2.8E-21 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS34290 164f9ba69b11c2facb4247a7ab7f45f7 311 Gene3D G3DSA:3.90.79.10 137 305 6.1E-51 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS34290 164f9ba69b11c2facb4247a7ab7f45f7 311 ProSitePatterns PS00893 Nudix box signature. 206 227 - T 17-03-2017 IPR020084 NUDIX hydrolase, conserved site GO:0016787 SHXM_RS34290 164f9ba69b11c2facb4247a7ab7f45f7 311 SUPERFAMILY SSF55811 124 306 2.44E-49 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS07845 c6502ef5fd33c4299be38345f22cd953 151 SUPERFAMILY SSF74853 52 142 3.92E-17 T 17-03-2017 IPR001322 Lamin Tail Domain SHXM_RS07845 c6502ef5fd33c4299be38345f22cd953 151 Gene3D G3DSA:2.60.40.1260 52 143 3.2E-14 T 17-03-2017 IPR001322 Lamin Tail Domain SHXM_RS07845 c6502ef5fd33c4299be38345f22cd953 151 Pfam PF00932 Lamin Tail Domain 28 142 5.6E-20 T 17-03-2017 IPR001322 Lamin Tail Domain SHXM_RS31690 54cc405125a6cee71330b6f0366a3e5c 302 SUPERFAMILY SSF161098 61 289 3.14E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31690 54cc405125a6cee71330b6f0366a3e5c 302 Gene3D G3DSA:1.10.3720.10 15 291 5.5E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31690 54cc405125a6cee71330b6f0366a3e5c 302 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 93 294 4.8E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS18695 5777cd880750614bb684963a9914ba3c 66 Gene3D G3DSA:3.10.20.30 1 66 6.9E-28 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS18695 5777cd880750614bb684963a9914ba3c 66 Pfam PF02597 ThiS family 3 66 2.7E-17 T 17-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 SHXM_RS18695 5777cd880750614bb684963a9914ba3c 66 TIGRFAM TIGR01683 thiS: thiamine biosynthesis protein ThiS 3 66 2.9E-23 T 17-03-2017 IPR010035 ThiS, thiamine-biosynthesis SHXM_RS18695 5777cd880750614bb684963a9914ba3c 66 SUPERFAMILY SSF54285 1 66 8.0E-19 T 17-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp SHXM_RS28850 836477ef5c327c66c30045abd6c79bcd 218 Pfam PF14016 Protein of unknown function (DUF4232) 86 209 1.4E-22 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 SUPERFAMILY SSF52922 548 649 5.5E-13 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 Gene3D G3DSA:3.40.920.10 42 241 2.3E-24 T 17-03-2017 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 TIGRFAM TIGR03710 OAFO_sf: 2-oxoacid:acceptor oxidoreductase, alpha subunit 42 643 4.2E-195 T 17-03-2017 IPR022367 2-oxoacid:acceptor oxidoreductase, alpha subunit KEGG: 00020+1.2.7.3|KEGG: 00720+1.2.7.3|MetaCyc: PWY-5392|MetaCyc: PWY-6969 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 Pfam PF01558 Pyruvate ferredoxin/flavodoxin oxidoreductase 50 238 1.7E-26 T 17-03-2017 IPR019752 Pyruvate/ketoisovalerate oxidoreductase, catalytic domain GO:0016903|GO:0055114 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 Pfam PF01855 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg 291 507 1.7E-50 T 17-03-2017 IPR002880 Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal GO:0016491|GO:0055114 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 Pfam PF17147 Pyruvate:ferredoxin oxidoreductase core domain II 549 614 6.8E-7 T 17-03-2017 IPR033412 Pyruvate:ferredoxin oxidoreductase, core domain II SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 Gene3D G3DSA:3.40.50.920 548 632 2.2E-10 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 Gene3D G3DSA:3.40.50.970 262 456 5.5E-72 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 SUPERFAMILY SSF53323 44 264 6.02E-18 T 17-03-2017 IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain GO:0016491|GO:0055114 SHXM_RS30905 47a29ee571900e8bc3860785e5b211cb 650 SUPERFAMILY SSF52518 264 532 1.57E-59 T 17-03-2017 IPR029061 Thiamin diphosphate-binding fold SHXM_RS04505 27840246e36041d642b3da92704c3ed4 577 SUPERFAMILY SSF143975 8 377 5.36E-126 T 17-03-2017 SHXM_RS04505 27840246e36041d642b3da92704c3ed4 577 Pfam PF00920 Dehydratase family 43 558 7.3E-183 T 17-03-2017 IPR000581 Dihydroxy-acid/6-phosphogluconate dehydratase GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS04505 27840246e36041d642b3da92704c3ed4 577 SUPERFAMILY SSF52016 379 564 8.63E-55 T 17-03-2017 IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel SHXM_RS04505 27840246e36041d642b3da92704c3ed4 577 ProSitePatterns PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 126 136 - T 17-03-2017 IPR020558 Dihydroxy-acid/6-phosphogluconate dehydratase, conserved site GO:0003824|GO:0008152 KEGG: 00290+4.2.1.9|KEGG: 00770+4.2.1.9|MetaCyc: PWY-5101|MetaCyc: PWY-5103|MetaCyc: PWY-5104|MetaCyc: PWY-7111 SHXM_RS30835 ffdf56664b523e521fe16a675b07476d 74 Gene3D G3DSA:3.40.1410.10 6 67 3.9E-13 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS30835 ffdf56664b523e521fe16a675b07476d 74 Pfam PF07702 UTRA domain 6 64 2.5E-11 T 17-03-2017 IPR011663 UbiC transcription regulator-associated GO:0003677|GO:0006355 SHXM_RS30835 ffdf56664b523e521fe16a675b07476d 74 SUPERFAMILY SSF64288 6 70 3.14E-14 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 68 309 6.4E-59 T 17-03-2017 SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 62 241 0.0038 T 17-03-2017 SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 SUPERFAMILY SSF51735 57 310 1.07E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 210 229 2.9E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 190 198 2.9E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 148 2.9E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 197 225 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 Gene3D G3DSA:3.40.50.720 50 310 2.3E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 137 148 6.2E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 231 248 6.2E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 63 80 6.2E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 184 200 6.2E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 210 229 6.2E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS40310 2a266c972b4f23bc8c30b89edc43a21a 320 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 272 292 6.2E-33 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 245 259 8.5E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 259 275 8.5E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 PRINTS PR00038 LuxR bacterial regulatory protein HTH signature 275 287 8.5E-9 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 Pfam PF13185 GAF domain 17 126 2.2E-8 T 17-03-2017 IPR003018 GAF domain GO:0005515 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 SUPERFAMILY SSF55781 17 153 3.49E-13 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 SUPERFAMILY SSF46894 236 305 5.1E-17 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 Pfam PF00196 Bacterial regulatory proteins, luxR family 244 298 9.3E-14 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 Gene3D G3DSA:3.30.450.40 17 157 1.5E-11 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 SMART SM00421 242 299 2.9E-17 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS38910 05560abee8c68922af4d5a8f7215b04e 306 Gene3D G3DSA:1.10.10.10 244 305 1.3E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS05990 23283818e77f4d3ad3995b9b2a531baf 78 SUPERFAMILY SSF143800 1 76 1.18E-26 T 17-03-2017 SHXM_RS05990 23283818e77f4d3ad3995b9b2a531baf 78 Gene3D G3DSA:2.30.170.40 2 77 1.5E-31 T 17-03-2017 SHXM_RS05990 23283818e77f4d3ad3995b9b2a531baf 78 Hamap MF_00373 50S ribosomal protein L28 [rpmB]. 1 71 20.556 T 17-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05990 23283818e77f4d3ad3995b9b2a531baf 78 TIGRFAM TIGR00009 L28: ribosomal protein bL28 1 58 5.8E-27 T 17-03-2017 IPR001383 Ribosomal protein L28 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS05990 23283818e77f4d3ad3995b9b2a531baf 78 Pfam PF00830 Ribosomal L28 family 4 60 4.2E-24 T 17-03-2017 IPR026569 Ribosomal protein L28/L24 GO:0003735 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS04985 32567f68e59c96eb12d1b801d265cf08 194 Gene3D G3DSA:2.60.200.20 99 177 1.2E-14 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS04985 32567f68e59c96eb12d1b801d265cf08 194 Pfam PF00498 FHA domain 104 177 4.9E-11 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS04985 32567f68e59c96eb12d1b801d265cf08 194 SUPERFAMILY SSF49879 96 182 1.91E-17 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS04985 32567f68e59c96eb12d1b801d265cf08 194 SMART SM00240 102 160 4.8E-4 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS22070 bbf0afe8c7f284367a8ae78f5498be4c 72 SUPERFAMILY SSF160582 1 69 5.75E-33 T 17-03-2017 SHXM_RS22070 bbf0afe8c7f284367a8ae78f5498be4c 72 Pfam PF03621 MbtH-like protein 1 53 1.6E-29 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS22070 bbf0afe8c7f284367a8ae78f5498be4c 72 SMART SM00923 3 53 2.0E-33 T 17-03-2017 IPR005153 MbtH-like protein SHXM_RS22070 bbf0afe8c7f284367a8ae78f5498be4c 72 Gene3D G3DSA:3.90.820.10 10 69 4.0E-33 T 17-03-2017 SHXM_RS34210 bba5dbdc6bb3a4d37bd144d93449b39e 213 Gene3D G3DSA:1.10.357.10 10 202 9.5E-42 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS34210 bba5dbdc6bb3a4d37bd144d93449b39e 213 SUPERFAMILY SSF46689 11 91 3.29E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS34210 bba5dbdc6bb3a4d37bd144d93449b39e 213 SUPERFAMILY SSF48498 92 203 8.26E-26 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS34210 bba5dbdc6bb3a4d37bd144d93449b39e 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 46 69 2.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34210 bba5dbdc6bb3a4d37bd144d93449b39e 213 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 25 38 2.2E-10 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS34210 bba5dbdc6bb3a4d37bd144d93449b39e 213 Pfam PF00440 Bacterial regulatory proteins, tetR family 25 71 4.8E-17 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS23165 f0a07d010be41d816f8f2e8a3b927eb7 314 SUPERFAMILY SSF161098 118 299 7.98E-30 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23165 f0a07d010be41d816f8f2e8a3b927eb7 314 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 143 312 4.5E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23165 f0a07d010be41d816f8f2e8a3b927eb7 314 Gene3D G3DSA:1.10.3720.10 77 299 1.2E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 Pfam PF08281 Sigma-70, region 4 104 157 1.3E-16 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 Gene3D G3DSA:1.10.10.10 104 162 1.4E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 Gene3D G3DSA:1.10.1740.10 11 84 4.5E-18 T 17-03-2017 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 SUPERFAMILY SSF88659 103 161 1.68E-13 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 Pfam PF04542 Sigma-70 region 2 17 83 5.3E-12 T 17-03-2017 IPR007627 RNA polymerase sigma-70 region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 12 159 6.4E-19 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 SUPERFAMILY SSF88946 11 94 3.18E-17 T 17-03-2017 IPR013325 RNA polymerase sigma factor, region 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS29785 c6a9ddea1fbceb21d362960a75017c39 195 TIGRFAM TIGR02983 SigE-fam_strep: RNA polymerase sigma-70 factor, sigma-E family 8 162 2.1E-48 T 17-03-2017 IPR014325 RNA polymerase sigma-E factor, actinobacteria GO:0016987 SHXM_RS37270 ab3cc6260ffa8d6644d8d4701b034dcb 215 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 8 106 5.0E-19 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS37270 ab3cc6260ffa8d6644d8d4701b034dcb 215 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 30 212 2.4E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS37270 ab3cc6260ffa8d6644d8d4701b034dcb 215 SUPERFAMILY SSF161098 10 203 2.62E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS37270 ab3cc6260ffa8d6644d8d4701b034dcb 215 Gene3D G3DSA:1.10.3720.10 7 211 1.2E-39 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS46625 15f31d7ad8f455b061bfce10f1a38b18 182 Gene3D G3DSA:3.40.30.10 18 167 1.4E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS46625 15f31d7ad8f455b061bfce10f1a38b18 182 SUPERFAMILY SSF52833 50 158 7.02E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS46625 15f31d7ad8f455b061bfce10f1a38b18 182 ProSitePatterns PS00194 Thioredoxin family active site. 77 95 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS30110 355567cb8268134bff80117471a17595 89 Pfam PF02597 ThiS family 9 89 1.9E-8 T 17-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 SHXM_RS30110 355567cb8268134bff80117471a17595 89 Gene3D G3DSA:3.10.20.30 8 89 2.4E-11 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS30110 355567cb8268134bff80117471a17595 89 SUPERFAMILY SSF54285 8 89 7.66E-12 T 17-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp SHXM_RS32870 5254acd4eed2f35235dad6f86fb10a8b 328 Pfam PF00248 Aldo/keto reductase family 18 307 1.0E-77 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS32870 5254acd4eed2f35235dad6f86fb10a8b 328 SUPERFAMILY SSF51430 7 308 4.85E-98 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS32870 5254acd4eed2f35235dad6f86fb10a8b 328 Gene3D G3DSA:3.20.20.100 5 318 1.2E-114 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 176 193 1.5E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 19 36 1.5E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 1.5E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 86 97 1.5E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 1.5E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 213 233 1.5E-19 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 27 246 1.9E-26 T 17-03-2017 SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 SUPERFAMILY SSF51735 14 249 4.97E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47975 d8ed5a6fba4381c85484180510e8628b 252 Gene3D G3DSA:3.40.50.720 14 249 2.9E-39 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS26195 ed01211b988134e1fbb91e45b5034f25 269 ProSitePatterns PS01227 Uncharacterized protein family UPF0012 signature. 143 163 - T 17-03-2017 IPR001110 Uncharacterised protein family UPF0012, conserved site SHXM_RS26195 ed01211b988134e1fbb91e45b5034f25 269 Gene3D G3DSA:3.60.110.10 1 258 9.7E-72 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS26195 ed01211b988134e1fbb91e45b5034f25 269 Pfam PF00795 Carbon-nitrogen hydrolase 2 246 4.2E-41 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS26195 ed01211b988134e1fbb91e45b5034f25 269 SUPERFAMILY SSF56317 1 254 4.06E-67 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS21975 f1289f6fdc7e29cdbc345cad56ec234d 331 Gene3D G3DSA:3.40.50.150 69 247 1.7E-66 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS21975 f1289f6fdc7e29cdbc345cad56ec234d 331 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 76 221 2.8E-27 T 17-03-2017 SHXM_RS21975 f1289f6fdc7e29cdbc345cad56ec234d 331 SUPERFAMILY SSF53335 95 210 1.08E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS05785 716bb65d1031ef32a1deb88ee3884b7c 1322 Gene3D G3DSA:3.10.350.10 1256 1286 4.0E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS05785 716bb65d1031ef32a1deb88ee3884b7c 1322 Pfam PF01476 LysM domain 1256 1291 7.6E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS05785 716bb65d1031ef32a1deb88ee3884b7c 1322 TIGRFAM TIGR02243 TIGR02243: putative baseplate assembly protein 707 1212 5.7E-58 T 17-03-2017 IPR011749 Conserved hypothetical protein CHP02243 SHXM_RS05785 716bb65d1031ef32a1deb88ee3884b7c 1322 SMART SM00257 1249 1296 5.8E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS22835 85f9fc18b467519fdda3e51ea189c697 481 Gene3D G3DSA:1.25.40.10 229 318 1.7E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22835 85f9fc18b467519fdda3e51ea189c697 481 Gene3D G3DSA:1.25.40.10 354 427 9.8E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22835 85f9fc18b467519fdda3e51ea189c697 481 SUPERFAMILY SSF48452 354 388 1.12E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS22835 85f9fc18b467519fdda3e51ea189c697 481 SUPERFAMILY SSF48452 220 295 1.12E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS03140 23c6c94e6d2f895727561f5b618c2c09 275 SUPERFAMILY SSF54060 57 268 9.42E-56 T 17-03-2017 SHXM_RS03140 23c6c94e6d2f895727561f5b618c2c09 275 Pfam PF04231 Endonuclease I 60 268 7.4E-39 T 17-03-2017 IPR007346 Endonuclease I GO:0004518 SHXM_RS21140 4c5b9f23a73298462def02d3c64502b2 314 Gene3D G3DSA:3.20.20.140 6 311 3.7E-105 T 17-03-2017 SHXM_RS21140 4c5b9f23a73298462def02d3c64502b2 314 SUPERFAMILY SSF51556 6 310 4.57E-80 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS21140 4c5b9f23a73298462def02d3c64502b2 314 Pfam PF04909 Amidohydrolase 7 310 1.0E-40 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS43315 f3814aca1ffa0d7da846b1aeb8c70036 149 SUPERFAMILY SSF51206 4 139 4.45E-22 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS43315 f3814aca1ffa0d7da846b1aeb8c70036 149 Pfam PF00027 Cyclic nucleotide-binding domain 23 110 1.5E-12 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS43315 f3814aca1ffa0d7da846b1aeb8c70036 149 SMART SM00100 4 122 1.3E-6 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS43315 f3814aca1ffa0d7da846b1aeb8c70036 149 Gene3D G3DSA:2.60.120.10 4 134 7.1E-17 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS38310 aea44234834fd3d8ac9fd879d3570844 448 Gene3D G3DSA:3.20.20.150 2 271 1.4E-85 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS38310 aea44234834fd3d8ac9fd879d3570844 448 Pfam PF05114 Protein of unknown function (DUF692) 5 269 2.4E-82 T 17-03-2017 IPR007801 Uncharacterised protein family UPF0276 SHXM_RS38310 aea44234834fd3d8ac9fd879d3570844 448 SUPERFAMILY SSF51658 21 224 7.46E-13 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS20400 05f6f55a8682e7c6bec4a25ca585581a 424 SUPERFAMILY SSF53182 342 419 9.29E-25 T 17-03-2017 SHXM_RS20400 05f6f55a8682e7c6bec4a25ca585581a 424 SUPERFAMILY SSF53182 166 314 9.29E-25 T 17-03-2017 SHXM_RS20400 05f6f55a8682e7c6bec4a25ca585581a 424 Gene3D G3DSA:3.40.630.20 166 384 2.0E-11 T 17-03-2017 IPR016125 Peptidase C15, pyroglutamyl peptidase I-like SHXM_RS16590 db7e164ae681db4845548ef4d3e9279e 370 SMART SM00382 179 316 6.2E-5 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS16590 db7e164ae681db4845548ef4d3e9279e 370 Pfam PF00004 ATPase family associated with various cellular activities (AAA) 183 313 4.4E-11 T 17-03-2017 IPR003959 ATPase, AAA-type, core GO:0005524 SHXM_RS16590 db7e164ae681db4845548ef4d3e9279e 370 Gene3D G3DSA:3.40.50.300 181 307 4.7E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16590 db7e164ae681db4845548ef4d3e9279e 370 SUPERFAMILY SSF52540 177 315 6.76E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS43615 8aa2a317edd7ef8cde06851ad104828e 81 Pfam PF04149 Domain of unknown function (DUF397) 26 74 2.0E-10 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS22540 c5715fde29da03f897ba84114e450ac1 405 Pfam PF01757 Acyltransferase family 19 357 3.9E-18 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 SUPERFAMILY SSF53092 63 230 1.73E-28 T 17-03-2017 IPR028980 Creatinase/Aminopeptidase P, N-terminal SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 Gene3D G3DSA:3.40.350.10 66 234 5.5E-39 T 17-03-2017 IPR029149 Creatinase/Aminopeptidase P/Spt16, N-terminal SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 ProSitePatterns PS00491 Aminopeptidase P and proline dipeptidase signature. 406 418 - T 17-03-2017 IPR001131 Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 Pfam PF00557 Metallopeptidase family M24 239 472 2.7E-49 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 Gene3D G3DSA:3.90.230.10 235 493 1.1E-67 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 SUPERFAMILY SSF55920 231 493 4.58E-68 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 SMART SM01011 63 204 5.3E-41 T 17-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 SHXM_RS27630 0dd809a64a4ee0a7e1743990ed10150d 498 Pfam PF05195 Aminopeptidase P, N-terminal domain 70 189 2.3E-19 T 17-03-2017 IPR007865 Aminopeptidase P, N-terminal GO:0004177|GO:0030145 SHXM_RS50495 7eb368de4e79ee46a2d5edeed00b1843 284 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 75 218 7.3E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50495 7eb368de4e79ee46a2d5edeed00b1843 284 SUPERFAMILY SSF161098 41 267 2.09E-49 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50495 7eb368de4e79ee46a2d5edeed00b1843 284 Gene3D G3DSA:1.10.3720.10 46 275 4.8E-45 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS18370 16c5f7383ed616623d6fff6aaaa5327c 366 Gene3D G3DSA:3.20.20.70 8 362 5.1E-119 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18370 16c5f7383ed616623d6fff6aaaa5327c 366 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 9 341 1.7E-76 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS18370 16c5f7383ed616623d6fff6aaaa5327c 366 SUPERFAMILY SSF51395 5 364 2.75E-111 T 17-03-2017 SHXM_RS28385 e5cf12037969259b715147c6e7fab393 275 Pfam PF12804 MobA-like NTP transferase domain 8 147 2.2E-28 T 17-03-2017 IPR025877 MobA-like NTP transferase SHXM_RS28385 e5cf12037969259b715147c6e7fab393 275 Gene3D G3DSA:3.90.550.10 6 194 5.0E-39 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS28385 e5cf12037969259b715147c6e7fab393 275 SUPERFAMILY SSF53448 7 183 9.71E-27 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS40915 1f0dbec6c6e587744151b3a6674ce233 129 Gene3D G3DSA:3.10.490.10 1 70 3.6E-14 T 17-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like SHXM_RS40915 1f0dbec6c6e587744151b3a6674ce233 129 SUPERFAMILY SSF110857 3 70 4.05E-8 T 17-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like SHXM_RS40915 1f0dbec6c6e587744151b3a6674ce233 129 Pfam PF06094 Gamma-glutamyl cyclotransferase, AIG2-like 5 70 1.4E-6 T 17-03-2017 IPR009288 Gamma-glutamylcyclotransferase, AIG2-like SHXM_RS48655 45e03048cf37db4a09bb8d56249b0b29 191 Pfam PF03601 Conserved hypothetical protein 698 58 189 4.5E-35 T 17-03-2017 IPR018383 Uncharacterised protein family UPF0324, prokaryote GO:0016021 SHXM_RS43950 fc0353ab13de65c57a976965bcfe71a9 208 Pfam PF13411 MerR HTH family regulatory protein 54 119 1.3E-13 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43950 fc0353ab13de65c57a976965bcfe71a9 208 SUPERFAMILY SSF46955 54 138 1.79E-14 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS43950 fc0353ab13de65c57a976965bcfe71a9 208 Gene3D G3DSA:1.10.1660.10 56 128 1.3E-13 T 17-03-2017 SHXM_RS43950 fc0353ab13de65c57a976965bcfe71a9 208 SMART SM00422 50 122 3.8E-18 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44260 6e8fd335dc319c49225b017fd9d95186 117 SUPERFAMILY SSF54593 8 114 1.17E-14 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS44260 6e8fd335dc319c49225b017fd9d95186 117 Gene3D G3DSA:3.10.180.10 8 112 8.1E-10 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS50080 98cb20b311d44bfd1c98ac42d685195c 325 Pfam PF13683 Integrase core domain 264 324 2.6E-8 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS50080 98cb20b311d44bfd1c98ac42d685195c 325 SUPERFAMILY SSF53098 180 323 1.02E-13 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS50080 98cb20b311d44bfd1c98ac42d685195c 325 Gene3D G3DSA:3.30.420.10 178 324 2.5E-11 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 ProSitePatterns PS00698 Glycosyl hydrolases family 9 active sites signature 2. 584 602 - T 17-03-2017 IPR033126 Glycosyl hydrolases family 9, Asp/Glu active sites KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 Pfam PF00759 Glycosyl hydrolase family 9 143 607 2.3E-101 T 17-03-2017 IPR001701 Glycoside hydrolase family 9 GO:0004553|GO:0005975 KEGG: 00500+3.2.1.4|MetaCyc: PWY-6788 SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 SUPERFAMILY SSF81296 51 139 3.64E-23 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 Pfam PF02927 Cellulase N-terminal ig-like domain 51 132 9.2E-25 T 17-03-2017 IPR004197 Cellulase, Ig-like domain GO:0005975|GO:0008810 SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 Gene3D G3DSA:1.50.10.10 142 611 1.5E-154 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 Gene3D G3DSA:2.60.40.10 51 139 9.1E-30 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS07640 893fe6900d7b17434c136e486c846e47 615 SUPERFAMILY SSF48208 142 612 2.18E-129 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 Gene3D G3DSA:2.30.40.10 23 56 1.2E-4 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 Gene3D G3DSA:2.30.40.10 391 435 1.2E-4 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 Pfam PF01979 Amidohydrolase family 53 431 3.0E-47 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 Gene3D G3DSA:3.20.20.140 57 390 2.0E-82 T 17-03-2017 SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 SUPERFAMILY SSF51338 381 439 4.03E-9 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 TIGRFAM TIGR02022 hutF: formiminoglutamate deiminase 4 456 2.4E-160 T 17-03-2017 IPR010252 Formiminoglutamate deiminase SHXM_RS24380 3db611eae4bf6178fe75279ba6d3ee37 458 SUPERFAMILY SSF51556 54 381 2.48E-71 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS13535 561c8e12312104c4f5b00c0a029789f4 386 Pfam PF02515 CoA-transferase family III 15 364 6.8E-86 T 17-03-2017 IPR003673 CoA-transferase family III GO:0003824 SHXM_RS13535 561c8e12312104c4f5b00c0a029789f4 386 Gene3D G3DSA:3.30.1540.10 234 302 2.4E-8 T 17-03-2017 SHXM_RS13535 561c8e12312104c4f5b00c0a029789f4 386 SUPERFAMILY SSF89796 13 375 3.92E-115 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS13535 561c8e12312104c4f5b00c0a029789f4 386 Gene3D G3DSA:3.40.50.10540 303 375 5.5E-96 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS13535 561c8e12312104c4f5b00c0a029789f4 386 Gene3D G3DSA:3.40.50.10540 12 218 5.5E-96 T 17-03-2017 IPR023606 CoA-transferase family III domain SHXM_RS32910 f867ade5800e1278679c49d0326ddb91 279 Pfam PF06386 Gas vesicle synthesis protein GvpL/GvpF 10 263 1.8E-52 T 17-03-2017 IPR009430 Gas vesicle protein GvpL/GvpF GO:0031411|GO:0031412 SHXM_RS00265 c8ba434af916d6d8972ca8f2bffd55dc 202 SUPERFAMILY SSF55874 78 189 2.07E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00265 c8ba434af916d6d8972ca8f2bffd55dc 202 Pfam PF13581 Histidine kinase-like ATPase domain 71 186 7.7E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS11875 2b13726ffbd943cd13003806ccf305da 261 SUPERFAMILY SSF52540 12 231 2.4E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11875 2b13726ffbd943cd13003806ccf305da 261 Gene3D G3DSA:3.40.50.300 12 230 1.9E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS11875 2b13726ffbd943cd13003806ccf305da 261 Pfam PF00005 ABC transporter 29 177 1.2E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS11875 2b13726ffbd943cd13003806ccf305da 261 ProSitePatterns PS00211 ABC transporters family signature. 150 164 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS11875 2b13726ffbd943cd13003806ccf305da 261 SMART SM00382 38 225 4.5E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS44145 c6126c97afd61f7d0c7dc560f4d68576 442 SUPERFAMILY SSF48576 122 431 4.89E-40 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS44145 c6126c97afd61f7d0c7dc560f4d68576 442 Gene3D G3DSA:1.10.600.10 114 437 2.6E-68 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS12180 a28ab295f776267b41a34520160030ca 410 Gene3D G3DSA:1.20.1250.20 213 391 9.5E-9 T 17-03-2017 SHXM_RS12180 a28ab295f776267b41a34520160030ca 410 Gene3D G3DSA:1.20.1250.20 16 192 1.8E-17 T 17-03-2017 SHXM_RS12180 a28ab295f776267b41a34520160030ca 410 SUPERFAMILY SSF103473 16 389 1.83E-40 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS12180 a28ab295f776267b41a34520160030ca 410 Pfam PF07690 Major Facilitator Superfamily 24 350 4.7E-22 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23170 97ada85dc01cc7898da00ae4561c6996 309 SUPERFAMILY SSF46894 246 304 4.08E-7 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS23170 97ada85dc01cc7898da00ae4561c6996 309 Gene3D G3DSA:1.10.10.10 248 303 3.2E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23170 97ada85dc01cc7898da00ae4561c6996 309 SMART SM00421 241 298 0.0029 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS04065 844e1c7ef0aadaa55a2cdf465e5e42ab 399 Pfam PF01179 Copper amine oxidase, enzyme domain 54 391 2.8E-44 T 17-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 SHXM_RS04065 844e1c7ef0aadaa55a2cdf465e5e42ab 399 Gene3D G3DSA:2.70.98.20 47 392 1.4E-59 T 17-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 SHXM_RS04065 844e1c7ef0aadaa55a2cdf465e5e42ab 399 SUPERFAMILY SSF49998 51 393 4.19E-59 T 17-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 SUPERFAMILY SSF52540 147 192 4.76E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 SUPERFAMILY SSF52540 974 1090 4.76E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 SUPERFAMILY SSF52540 1 95 4.76E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 Pfam PF13558 Putative exonuclease SbcCD, C subunit 990 1054 2.9E-13 T 17-03-2017 SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 Pfam PF13476 AAA domain 5 211 1.4E-21 T 17-03-2017 SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 Gene3D G3DSA:3.40.50.300 981 1093 3.9E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 Gene3D G3DSA:3.40.50.300 154 210 3.9E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 Gene3D G3DSA:3.40.50.300 1 120 3.9E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08675 094485dfff6236b8862487ebb1c47247 1099 Gene3D G3DSA:3.40.50.300 299 322 3.9E-33 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22090 1fcc4593fe9152d3ae4b013269041d51 124 Hamap MF_00454 Putative fluoride ion transporter CrcB [crcB]. 3 120 19.135 T 17-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 SHXM_RS22090 1fcc4593fe9152d3ae4b013269041d51 124 Pfam PF02537 CrcB-like protein, Camphor Resistance (CrcB) 4 115 2.7E-24 T 17-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 SHXM_RS22090 1fcc4593fe9152d3ae4b013269041d51 124 TIGRFAM TIGR00494 crcB: protein CrcB 4 118 7.5E-28 T 17-03-2017 IPR003691 Putative fluoride ion transporter CrcB GO:0016021 SHXM_RS19295 242b7d627b464d398db1e54a56d94927 307 SUPERFAMILY SSF56784 45 304 1.47E-55 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19295 242b7d627b464d398db1e54a56d94927 307 TIGRFAM TIGR01484 HAD-SF-IIB: HAD hydrolase, family IIB 46 273 2.8E-23 T 17-03-2017 IPR006379 HAD-superfamily hydrolase, subfamily IIB Reactome: R-HSA-446205 SHXM_RS19295 242b7d627b464d398db1e54a56d94927 307 TIGRFAM TIGR00099 Cof-subfamily: Cof-like hydrolase 46 300 2.1E-43 T 17-03-2017 IPR000150 Cof protein GO:0016787 SHXM_RS19295 242b7d627b464d398db1e54a56d94927 307 Pfam PF08282 haloacid dehalogenase-like hydrolase 47 300 1.0E-43 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19295 242b7d627b464d398db1e54a56d94927 307 Gene3D G3DSA:3.40.50.1000 209 304 1.3E-47 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS19295 242b7d627b464d398db1e54a56d94927 307 Gene3D G3DSA:3.40.50.1000 44 114 1.3E-47 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS18870 2aca28a63e92892bfa208002aebf0a61 546 Pfam PF13631 Cytochrome b(N-terminal)/b6/petB 125 298 1.5E-56 T 17-03-2017 IPR005797 Cytochrome b/b6, N-terminal GO:0009055|GO:0016020|GO:0016491 Reactome: R-HSA-611105 SHXM_RS18870 2aca28a63e92892bfa208002aebf0a61 546 SUPERFAMILY SSF81342 24 301 5.49E-62 T 17-03-2017 IPR016174 Di-haem cytochrome, transmembrane GO:0016020|GO:0022904 Reactome: R-HSA-611105 SHXM_RS18870 2aca28a63e92892bfa208002aebf0a61 546 Gene3D G3DSA:1.20.810.10 24 445 9.2E-89 T 17-03-2017 IPR027387 Cytochrome b/b6-like domain Reactome: R-HSA-611105 SHXM_RS30755 b8b25d2d6ed92657f08c726729a7ca2e 119 Hamap MF_01394 NAD(P)H-quinone oxidoreductase subunit 3, chloroplastic [ndhC]. 1 119 17.683 T 17-03-2017 IPR023043 NAD(P)H-quinone oxidoreductase subunit 3, bacterial/plastid GO:0016651|GO:0055114 SHXM_RS30755 b8b25d2d6ed92657f08c726729a7ca2e 119 Pfam PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 19 118 2.8E-36 T 17-03-2017 IPR000440 NADH:ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS04225 303a235ce56dd12cd9c6495981621294 526 Pfam PF13556 PucR C-terminal helix-turn-helix domain 460 517 2.6E-10 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS04225 303a235ce56dd12cd9c6495981621294 526 Pfam PF13556 PucR C-terminal helix-turn-helix domain 368 412 1.4E-8 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS03095 301abcc42ef2c292181d4ce1faf8e5ab 218 Pfam PF00440 Bacterial regulatory proteins, tetR family 48 78 2.5E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS03095 301abcc42ef2c292181d4ce1faf8e5ab 218 Gene3D G3DSA:1.10.357.10 14 214 1.8E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS03095 301abcc42ef2c292181d4ce1faf8e5ab 218 SUPERFAMILY SSF46689 15 98 1.95E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS03095 301abcc42ef2c292181d4ce1faf8e5ab 218 Pfam PF13305 WHG domain 109 190 1.0E-6 T 17-03-2017 IPR025996 WHG domain SHXM_RS03095 301abcc42ef2c292181d4ce1faf8e5ab 218 SUPERFAMILY SSF48498 106 214 3.26E-12 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11055 58f5d59eb2ffed9892964c7af3b46194 740 SUPERFAMILY SSF158472 675 722 3.01E-6 T 17-03-2017 SHXM_RS11055 58f5d59eb2ffed9892964c7af3b46194 740 Pfam PF00672 HAMP domain 654 722 1.1E-7 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS11055 58f5d59eb2ffed9892964c7af3b46194 740 SMART SM00304 673 725 0.2 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS11055 58f5d59eb2ffed9892964c7af3b46194 740 SMART SM00304 331 383 0.31 T 17-03-2017 IPR003660 HAMP domain GO:0004871|GO:0007165|GO:0016021 SHXM_RS21270 64b4026dc7fe2bce91f5004b659dcc7c 119 Gene3D G3DSA:3.30.428.10 4 119 5.9E-38 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS21270 64b4026dc7fe2bce91f5004b659dcc7c 119 Pfam PF01230 HIT domain 17 112 4.3E-24 T 17-03-2017 IPR001310 Histidine triad (HIT) protein SHXM_RS21270 64b4026dc7fe2bce91f5004b659dcc7c 119 PRINTS PR00332 Histidine triad family signature 10 26 5.1E-19 T 17-03-2017 IPR001310 Histidine triad (HIT) protein SHXM_RS21270 64b4026dc7fe2bce91f5004b659dcc7c 119 PRINTS PR00332 Histidine triad family signature 99 109 5.1E-19 T 17-03-2017 IPR001310 Histidine triad (HIT) protein SHXM_RS21270 64b4026dc7fe2bce91f5004b659dcc7c 119 PRINTS PR00332 Histidine triad family signature 31 49 5.1E-19 T 17-03-2017 IPR001310 Histidine triad (HIT) protein SHXM_RS21270 64b4026dc7fe2bce91f5004b659dcc7c 119 SUPERFAMILY SSF54197 7 118 1.86E-34 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS14055 efc0f6a592e55a90cd4201887f733830 279 Pfam PF00753 Metallo-beta-lactamase superfamily 36 237 1.8E-9 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14055 efc0f6a592e55a90cd4201887f733830 279 SMART SM00849 37 204 1.3E-9 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14055 efc0f6a592e55a90cd4201887f733830 279 SUPERFAMILY SSF56281 201 245 1.13E-29 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14055 efc0f6a592e55a90cd4201887f733830 279 SUPERFAMILY SSF56281 16 171 1.13E-29 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS14055 efc0f6a592e55a90cd4201887f733830 279 Gene3D G3DSA:3.60.15.10 14 253 1.2E-36 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 Pfam PF01447 Thermolysin metallopeptidase, catalytic domain 218 360 4.2E-50 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 Gene3D G3DSA:3.10.170.10 218 365 4.2E-46 T 17-03-2017 IPR013856 Peptidase M4 domain GO:0004222 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 SUPERFAMILY SSF55486 216 538 4.03E-83 T 17-03-2017 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 373 384 1.7E-15 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 316 336 1.7E-15 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 352 368 1.7E-15 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 PRINTS PR00730 Thermolysin metalloprotease (M4) family signature 440 456 1.7E-15 T 17-03-2017 IPR023612 Peptidase M4 GO:0004222|GO:0006508 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 Pfam PF07504 Fungalysin/Thermolysin Propeptide Motif 82 126 4.8E-14 T 17-03-2017 IPR011096 FTP domain SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 Gene3D G3DSA:1.10.390.10 366 538 1.1E-51 T 17-03-2017 SHXM_RS25945 1ef5159714bb3ec7837313cc38d12b9a 539 Pfam PF02868 Thermolysin metallopeptidase, alpha-helical domain 364 538 5.5E-52 T 17-03-2017 IPR001570 Peptidase M4, C-terminal GO:0004222 SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 Pfam PF09339 IclR helix-turn-helix domain 18 69 2.1E-11 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 SMART SM00346 16 106 1.4E-16 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 Gene3D G3DSA:1.10.10.10 16 78 2.7E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 SUPERFAMILY SSF46785 16 89 1.6E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 Gene3D G3DSA:3.30.450.40 89 258 2.3E-54 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 Pfam PF01614 Bacterial transcriptional regulator 134 255 1.5E-29 T 17-03-2017 IPR014757 Transcription regulator IclR, C-terminal SHXM_RS42380 5f4a72e781bcbd5e87ab057512edbf3e 264 SUPERFAMILY SSF55781 87 258 7.19E-49 T 17-03-2017 IPR029016 GAF domain-like SHXM_RS29975 8d2b7a4085b5168bc16e2c06579641a7 408 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 212 407 6.1E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29975 8d2b7a4085b5168bc16e2c06579641a7 408 Pfam PF00072 Response regulator receiver domain 29 130 2.1E-8 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS29975 8d2b7a4085b5168bc16e2c06579641a7 408 SMART SM00331 183 407 9.2E-17 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29975 8d2b7a4085b5168bc16e2c06579641a7 408 SMART SM00448 26 141 3.2E-5 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS29975 8d2b7a4085b5168bc16e2c06579641a7 408 Gene3D G3DSA:3.40.50.2300 19 151 3.6E-16 T 17-03-2017 SHXM_RS29975 8d2b7a4085b5168bc16e2c06579641a7 408 SUPERFAMILY SSF52172 24 164 2.13E-15 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS15035 2c44c30a1ae8eccabf0fdc2997ce8fe6 93 Pfam PF06902 Divergent 4Fe-4S mono-cluster 10 70 1.4E-24 T 17-03-2017 IPR010693 Divergent 4Fe-4S mono-cluster SHXM_RS15035 2c44c30a1ae8eccabf0fdc2997ce8fe6 93 Gene3D G3DSA:3.30.70.20 16 72 8.4E-4 T 17-03-2017 SHXM_RS28160 d3525e568abfcb370d0f147f6cc340a7 255 Pfam PF12089 Transmembrane domain of unknown function (DUF3566) 135 253 1.7E-43 T 17-03-2017 IPR021949 Domain of unknown function DUF3566. transmembrane SHXM_RS50480 a70dd173631d9c0e7c7f3aa5b22cd154 104 Pfam PF13384 Homeodomain-like domain 17 56 1.2E-6 T 17-03-2017 SHXM_RS50480 a70dd173631d9c0e7c7f3aa5b22cd154 104 SUPERFAMILY SSF46689 2 56 9.68E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS25865 dc935ad325f4974a598830ffc24da136 315 SUPERFAMILY SSF53448 35 272 1.21E-56 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS25865 dc935ad325f4974a598830ffc24da136 315 Gene3D G3DSA:3.90.550.10 35 175 5.4E-10 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS25865 dc935ad325f4974a598830ffc24da136 315 Pfam PF00535 Glycosyl transferase family 2 36 151 8.0E-10 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS13835 7606a30e2f95f8cdfd2caf772a1aeb43 224 SUPERFAMILY SSF56784 6 219 2.14E-35 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS13835 7606a30e2f95f8cdfd2caf772a1aeb43 224 Pfam PF13419 Haloacid dehalogenase-like hydrolase 8 195 3.4E-12 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS13835 7606a30e2f95f8cdfd2caf772a1aeb43 224 Gene3D G3DSA:3.40.50.1000 70 219 1.5E-29 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS17500 6b9ec8448a1b2d42563300b7ea65b587 228 SMART SM01007 23 196 1.1E-60 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS17500 6b9ec8448a1b2d42563300b7ea65b587 228 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 24 195 8.7E-49 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS17500 6b9ec8448a1b2d42563300b7ea65b587 228 Gene3D G3DSA:3.40.225.10 19 227 5.8E-71 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS17500 6b9ec8448a1b2d42563300b7ea65b587 228 SUPERFAMILY SSF53639 18 227 6.47E-64 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS20225 62012ab7615cf7c3f0276cfed629835b 152 PIRSF PIRSF000239 1 152 3.5E-28 T 17-03-2017 IPR024706 Peroxiredoxin, AhpC-type KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS20225 62012ab7615cf7c3f0276cfed629835b 152 SUPERFAMILY SSF52833 1 152 3.61E-49 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS20225 62012ab7615cf7c3f0276cfed629835b 152 Gene3D G3DSA:3.40.30.10 2 152 8.8E-51 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS20225 62012ab7615cf7c3f0276cfed629835b 152 Pfam PF00578 AhpC/TSA family 5 130 4.2E-41 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 Gene3D G3DSA:3.40.30.10 1 160 5.0E-62 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 PRINTS PR01011 Glutathione peroxidase family signature 56 72 8.3E-18 T 17-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 PRINTS PR01011 Glutathione peroxidase family signature 21 38 8.3E-18 T 17-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 PRINTS PR01011 Glutathione peroxidase family signature 122 131 8.3E-18 T 17-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 SUPERFAMILY SSF52833 1 160 9.17E-55 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 PIRSF PIRSF000303 1 162 1.8E-61 T 17-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 SHXM_RS07645 f05bfb6f2e7d17c9df46d670e4940c19 162 Pfam PF00255 Glutathione peroxidase 3 109 1.7E-38 T 17-03-2017 IPR000889 Glutathione peroxidase GO:0004602|GO:0006979|GO:0055114 Reactome: R-HSA-3299685 SHXM_RS27645 c65c63f83cb52019af704124aa90e4b9 167 Pfam PF13581 Histidine kinase-like ATPase domain 11 150 4.6E-24 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27645 c65c63f83cb52019af704124aa90e4b9 167 Gene3D G3DSA:3.30.565.10 21 149 5.7E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS27645 c65c63f83cb52019af704124aa90e4b9 167 SUPERFAMILY SSF55874 32 149 9.66E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 145 160 3.7E-13 T 17-03-2017 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 3.7E-13 T 17-03-2017 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 278 293 3.7E-13 T 17-03-2017 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 Pfam PF01494 FAD binding domain 5 320 9.5E-20 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 Gene3D G3DSA:3.50.50.60 4 172 2.5E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 Gene3D G3DSA:3.50.50.60 266 346 2.5E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 SUPERFAMILY SSF51905 265 370 3.14E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01215 1c584a9907b844bf46ad99c97d19a212 380 SUPERFAMILY SSF51905 4 166 3.14E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 20 39 1.3E-8 T 17-03-2017 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 270 292 1.3E-8 T 17-03-2017 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 120 138 1.3E-8 T 17-03-2017 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 19 41 1.0E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 158 182 1.0E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 280 298 1.0E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 143 155 1.0E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 121 129 1.0E-13 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 Gene3D G3DSA:3.50.50.60 146 243 3.3E-35 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 Gene3D G3DSA:3.50.50.60 268 315 2.3E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 Gene3D G3DSA:3.50.50.60 17 145 2.3E-29 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 SUPERFAMILY SSF51905 14 325 3.77E-27 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS49325 9b45331872ddd9b44271c8b9e6eb0e9f 335 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 19 295 1.6E-15 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18305 d60459ab5e3dff6b68f9af5964ef61ab 272 ProSitePatterns PS00167 Tryptophan synthase alpha chain signature. 52 65 - T 17-03-2017 IPR018204 Tryptophan synthase, alpha chain, active site GO:0004834 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18305 d60459ab5e3dff6b68f9af5964ef61ab 272 Hamap MF_00131 Tryptophan synthase alpha chain [trpA]. 18 267 34.196 T 17-03-2017 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18305 d60459ab5e3dff6b68f9af5964ef61ab 272 SUPERFAMILY SSF51366 9 249 7.46E-80 T 17-03-2017 IPR011060 Ribulose-phosphate binding barrel GO:0003824|GO:0008152 SHXM_RS18305 d60459ab5e3dff6b68f9af5964ef61ab 272 Gene3D G3DSA:3.20.20.70 11 270 1.6E-93 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS18305 d60459ab5e3dff6b68f9af5964ef61ab 272 TIGRFAM TIGR00262 trpA: tryptophan synthase, alpha subunit 16 264 7.7E-70 T 17-03-2017 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS18305 d60459ab5e3dff6b68f9af5964ef61ab 272 Pfam PF00290 Tryptophan synthase alpha chain 13 267 7.0E-78 T 17-03-2017 IPR002028 Tryptophan synthase, alpha chain GO:0004834|GO:0006568 KEGG: 00260+4.2.1.20|KEGG: 00400+4.2.1.20 SHXM_RS22560 51370417036455547f067fed4dd6935f 122 SUPERFAMILY SSF46785 3 102 9.73E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22560 51370417036455547f067fed4dd6935f 122 SMART SM00418 2 84 2.6E-18 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS22560 51370417036455547f067fed4dd6935f 122 Pfam PF12840 Helix-turn-helix domain 4 63 2.9E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS22560 51370417036455547f067fed4dd6935f 122 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 55 70 1.2E-10 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS22560 51370417036455547f067fed4dd6935f 122 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 4 19 1.2E-10 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS22560 51370417036455547f067fed4dd6935f 122 PRINTS PR00778 Bacterial regulatory protein ArsR family signature 40 55 1.2E-10 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS22560 51370417036455547f067fed4dd6935f 122 Gene3D G3DSA:1.10.10.10 3 106 3.5E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33385 645453aa57728f2763b374fcccb29b3d 313 SUPERFAMILY SSF52540 7 225 9.37E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33385 645453aa57728f2763b374fcccb29b3d 313 SMART SM00382 31 249 2.1E-9 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS33385 645453aa57728f2763b374fcccb29b3d 313 Gene3D G3DSA:3.40.50.300 6 229 1.1E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33385 645453aa57728f2763b374fcccb29b3d 313 ProSitePatterns PS00211 ABC transporters family signature. 135 149 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS33385 645453aa57728f2763b374fcccb29b3d 313 Pfam PF00005 ABC transporter 22 163 4.6E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS02345 950314149d72baf425ae3427db6dd8ba 202 SUPERFAMILY SSF52540 2 194 9.12E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02345 950314149d72baf425ae3427db6dd8ba 202 Gene3D G3DSA:3.40.50.300 2 194 9.2E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02345 950314149d72baf425ae3427db6dd8ba 202 SMART SM00382 25 192 1.9E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02345 950314149d72baf425ae3427db6dd8ba 202 Pfam PF00005 ABC transporter 18 144 2.3E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS48410 c1eac4a3cd8fe4d369bfa6d6c1fc82bb 280 Gene3D G3DSA:3.20.20.140 1 280 6.5E-72 T 17-03-2017 SHXM_RS48410 c1eac4a3cd8fe4d369bfa6d6c1fc82bb 280 Pfam PF04909 Amidohydrolase 4 280 7.7E-44 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS48410 c1eac4a3cd8fe4d369bfa6d6c1fc82bb 280 SUPERFAMILY SSF51556 3 280 2.11E-66 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS34495 bd84ace9c1c36216906f6fd1ec2d4d31 341 PIRSF PIRSF000355 7 340 3.1E-100 T 17-03-2017 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34495 bd84ace9c1c36216906f6fd1ec2d4d31 341 Gene3D G3DSA:1.10.620.20 20 308 7.1E-98 T 17-03-2017 IPR012348 Ribonucleotide reductase-related GO:0016491|GO:0055114 Reactome: R-HSA-499943 SHXM_RS34495 bd84ace9c1c36216906f6fd1ec2d4d31 341 Pfam PF00268 Ribonucleotide reductase, small chain 20 304 8.4E-81 T 17-03-2017 IPR000358 Ribonucleotide reductase small subunit GO:0009186|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SHXM_RS34495 bd84ace9c1c36216906f6fd1ec2d4d31 341 SUPERFAMILY SSF47240 21 340 2.96E-88 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS50785 b704164bbce33606f84d19f330a79c71 177 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 45 118 4.0E-6 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS50785 b704164bbce33606f84d19f330a79c71 177 SUPERFAMILY SSF50475 39 160 8.51E-16 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS50785 b704164bbce33606f84d19f330a79c71 177 Gene3D G3DSA:2.30.110.10 35 162 1.1E-13 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS33985 978b213186dde8ee0aa9ea7a962a698a 294 Gene3D G3DSA:3.40.50.10320 6 292 1.4E-94 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS33985 978b213186dde8ee0aa9ea7a962a698a 294 Hamap MF_01696 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase [mshB]. 9 292 42.349 T 17-03-2017 IPR017810 Mycothiol biosynthesis protein, MshB GO:0035595 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS33985 978b213186dde8ee0aa9ea7a962a698a 294 SUPERFAMILY SSF102588 7 292 2.62E-70 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS33985 978b213186dde8ee0aa9ea7a962a698a 294 Pfam PF02585 GlcNAc-PI de-N-acetylase 10 160 8.7E-25 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS33985 978b213186dde8ee0aa9ea7a962a698a 294 TIGRFAM TIGR03445 mycothiol_MshB: N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase 10 292 4.0E-127 T 17-03-2017 IPR017810 Mycothiol biosynthesis protein, MshB GO:0035595 KEGG: 00630+3.5.1.10|KEGG: 00670+3.5.1.10|MetaCyc: PWY-2201|MetaCyc: PWY-5497 SHXM_RS30645 cbbcf80e94b7f5815f78b8bc1be16a9b 224 TIGRFAM TIGR00421 ubiX_pad: polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases 89 211 2.8E-36 T 17-03-2017 IPR004507 Flavin prenyltransferase UbiX/Pad1 SHXM_RS30645 cbbcf80e94b7f5815f78b8bc1be16a9b 224 Hamap MF_01984 Flavin prenyltransferase UbiX [ubiX]. 5 213 30.758 T 17-03-2017 IPR004507 Flavin prenyltransferase UbiX/Pad1 SHXM_RS30645 cbbcf80e94b7f5815f78b8bc1be16a9b 224 SUPERFAMILY SSF52507 6 213 9.16E-44 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS30645 cbbcf80e94b7f5815f78b8bc1be16a9b 224 Pfam PF02441 Flavoprotein 7 154 2.9E-22 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS30645 cbbcf80e94b7f5815f78b8bc1be16a9b 224 Gene3D G3DSA:3.40.50.1950 6 214 2.1E-64 T 17-03-2017 IPR003382 Flavoprotein GO:0003824 Reactome: R-HSA-196783 SHXM_RS02245 dd077e66d845f8703a7cccdc78708557 352 SUPERFAMILY SSF46894 283 338 2.65E-9 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS02245 dd077e66d845f8703a7cccdc78708557 352 SMART SM00421 273 332 1.6E-4 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS02245 dd077e66d845f8703a7cccdc78708557 352 Pfam PF00196 Bacterial regulatory proteins, luxR family 285 328 5.3E-6 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS02245 dd077e66d845f8703a7cccdc78708557 352 Gene3D G3DSA:1.10.10.10 284 337 4.4E-10 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42345 c1f3b5d75a4eaf5328dac767feddc20a 357 Pfam PF03595 Voltage-dependent anion channel 45 329 5.6E-22 T 17-03-2017 IPR004695 Voltage-dependent anion channel GO:0016021|GO:0055085 SHXM_RS02765 921381e36b3eec67d094e8848f38c43e 163 Pfam PF16571 FBP C-terminal treble-clef zinc-finger 8 161 1.2E-61 T 17-03-2017 IPR032330 Elongation factor G-binding protein, C-terminal treble-clef zinc-finger SHXM_RS50885 cddaebea9ef32c3e150f33e7b7da14f9 1753 Gene3D G3DSA:3.40.50.300 279 439 1.9E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50885 cddaebea9ef32c3e150f33e7b7da14f9 1753 Pfam PF05729 NACHT domain 290 468 2.7E-6 T 17-03-2017 SHXM_RS50885 cddaebea9ef32c3e150f33e7b7da14f9 1753 SUPERFAMILY SSF52540 385 518 1.98E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50885 cddaebea9ef32c3e150f33e7b7da14f9 1753 SUPERFAMILY SSF52540 269 355 1.98E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS45570 b35bff43048997c1145fc5462e020e88 118 Pfam PF12680 SnoaL-like domain 17 113 3.1E-8 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS45570 b35bff43048997c1145fc5462e020e88 118 Gene3D G3DSA:3.10.450.50 9 116 2.4E-14 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS45570 b35bff43048997c1145fc5462e020e88 118 SUPERFAMILY SSF54427 9 115 2.36E-14 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS20755 bb9e247189caa4d02a9a8222030335a1 324 SUPERFAMILY SSF161098 81 306 1.28E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20755 bb9e247189caa4d02a9a8222030335a1 324 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 115 311 1.1E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20755 bb9e247189caa4d02a9a8222030335a1 324 Gene3D G3DSA:1.10.3720.10 39 308 2.2E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS31745 f09b4da3809a8d622b002edcfd7e795e 152 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 67 132 3.9E-20 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS31745 f09b4da3809a8d622b002edcfd7e795e 152 SUPERFAMILY SSF50249 18 133 6.85E-37 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS31745 f09b4da3809a8d622b002edcfd7e795e 152 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 30 64 5.5E-16 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS08410 f3977cf7a49695bb12df5ed947bb39f5 316 Pfam PF09678 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) 39 280 1.6E-82 T 17-03-2017 IPR019108 Cytochrome c oxidase caa3-type, assembly factor CtaG-related SHXM_RS03920 74660915b9eadae9823f32e04402629e 272 Pfam PF13628 Domain of unknown function (DUF4142) 54 188 5.7E-19 T 17-03-2017 IPR025419 Domain of unknown function DUF4142 SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 144 172 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 Pfam PF00106 short chain dehydrogenase 9 198 5.8E-55 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 Gene3D G3DSA:3.40.50.720 7 231 1.9E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 9 189 6.9E-4 T 17-03-2017 SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 137 145 3.4E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 157 176 3.4E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 84 95 3.4E-11 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 SUPERFAMILY SSF51735 6 232 5.2E-68 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 84 95 5.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 157 176 5.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 131 147 5.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 177 194 5.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS18360 ed8ad43cc4c631b7f77ebfae9cf65ecd 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 10 27 5.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS41255 9c764919641cf90245de995b841b8255 373 SUPERFAMILY SSF53822 21 352 3.21E-49 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS41255 9c764919641cf90245de995b841b8255 373 Gene3D G3DSA:3.40.50.2300 21 189 1.3E-35 T 17-03-2017 SHXM_RS41255 9c764919641cf90245de995b841b8255 373 Pfam PF13458 Periplasmic binding protein 21 341 2.4E-36 T 17-03-2017 IPR028081 Leucine-binding protein domain SHXM_RS11780 af495ded2a2ad4aca9844fd6bfc5c1fa 203 SUPERFAMILY SSF81301 16 169 8.17E-6 T 17-03-2017 SHXM_RS47685 324532baf295cc01e4fb51bdab3d4735 191 Gene3D G3DSA:2.10.150.10 80 176 1.5E-28 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47685 324532baf295cc01e4fb51bdab3d4735 191 Pfam PF00699 Urease beta subunit 81 175 6.7E-26 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS47685 324532baf295cc01e4fb51bdab3d4735 191 SUPERFAMILY SSF51278 76 176 8.76E-24 T 17-03-2017 IPR002019 Urease, beta subunit KEGG: 00220+3.5.1.5|KEGG: 00230+3.5.1.5|KEGG: 00791+3.5.1.5|MetaCyc: PWY-5704 SHXM_RS12600 4df58fa469df5137550efeed0ee43927 188 Gene3D G3DSA:3.30.428.10 46 185 4.3E-37 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS12600 4df58fa469df5137550efeed0ee43927 188 SUPERFAMILY SSF54197 22 179 1.02E-39 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS12600 4df58fa469df5137550efeed0ee43927 188 Pfam PF01230 HIT domain 63 151 1.3E-10 T 17-03-2017 IPR001310 Histidine triad (HIT) protein SHXM_RS12430 2184b23ab13172ca65173609ee809c8a 598 TIGRFAM TIGR00247 TIGR00247: conserved hypothetical protein, YceG family 287 593 7.1E-42 T 17-03-2017 IPR003770 Uncharacterised protein family UPF0755, YceG-like SHXM_RS12430 2184b23ab13172ca65173609ee809c8a 598 Pfam PF02618 YceG-like family 291 588 5.2E-61 T 17-03-2017 IPR003770 Uncharacterised protein family UPF0755, YceG-like SHXM_RS12430 2184b23ab13172ca65173609ee809c8a 598 Gene3D G3DSA:3.30.160.60 564 595 2.1E-4 T 17-03-2017 IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain GO:0003676 SHXM_RS44815 a3f96c3766c2c601f949d2aeb9bab4e9 243 Pfam PF04250 Protein of unknown function (DUF429) 22 231 1.1E-48 T 17-03-2017 IPR007362 Protein of unknown function DUF429 SHXM_RS25140 4b095e90988082c589eaacd115cde46f 347 Pfam PF03631 Virulence factor BrkB 36 282 3.6E-45 T 17-03-2017 IPR017039 Virulence factor BrkB SHXM_RS42650 9676cb412f9dc05690172cf19fe00021 153 SUPERFAMILY SSF55874 36 133 2.69E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42650 9676cb412f9dc05690172cf19fe00021 153 Gene3D G3DSA:3.30.565.10 39 133 2.2E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS42650 9676cb412f9dc05690172cf19fe00021 153 Pfam PF13581 Histidine kinase-like ATPase domain 23 134 1.8E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS47235 39934478b193d458191507b1fdcb8f5e 275 SUPERFAMILY SSF161098 6 274 1.03E-67 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47235 39934478b193d458191507b1fdcb8f5e 275 Gene3D G3DSA:1.10.3720.10 5 262 9.0E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS47235 39934478b193d458191507b1fdcb8f5e 275 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 91 261 1.7E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 Pfam PF00890 FAD binding domain 49 82 4.9E-5 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 Gene3D G3DSA:3.50.50.60 246 351 5.6E-82 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 Gene3D G3DSA:3.50.50.60 47 168 5.6E-82 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 Gene3D G3DSA:3.50.50.60 486 585 5.6E-82 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 SUPERFAMILY SSF51905 46 208 4.23E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 SUPERFAMILY SSF51905 238 355 4.23E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 SUPERFAMILY SSF51905 526 582 4.23E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS25440 90e16a5f5c9f580409a7e6d2909cf79c 635 Pfam PF05199 GMC oxidoreductase 521 578 8.5E-14 T 17-03-2017 IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal GO:0016614|GO:0055114 Reactome: R-HSA-6798163 SHXM_RS26425 a569fe684231556ad54a512924fa56ac 161 Gene3D G3DSA:3.10.450.50 5 146 8.1E-51 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS26425 a569fe684231556ad54a512924fa56ac 161 Pfam PF13474 SnoaL-like domain 10 138 3.2E-31 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS26425 a569fe684231556ad54a512924fa56ac 161 SUPERFAMILY SSF54427 3 138 1.47E-39 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS35720 0469df4ebf860d06c15a8b3be69af0a8 287 SUPERFAMILY SSF47413 31 82 1.24E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35720 0469df4ebf860d06c15a8b3be69af0a8 287 SMART SM00530 10 83 4.1E-7 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS35720 0469df4ebf860d06c15a8b3be69af0a8 287 Gene3D G3DSA:1.10.260.40 2 82 1.1E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS35720 0469df4ebf860d06c15a8b3be69af0a8 287 Pfam PF13560 Helix-turn-helix domain 6 86 5.4E-16 T 17-03-2017 SHXM_RS04850 9ca495ac7def8423ad537b5decc2aeb7 652 SUPERFAMILY SSF56112 7 305 2.4E-68 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS04850 9ca495ac7def8423ad537b5decc2aeb7 652 Gene3D G3DSA:3.30.200.20 3 75 3.6E-24 T 17-03-2017 SHXM_RS04850 9ca495ac7def8423ad537b5decc2aeb7 652 ProSitePatterns PS00109 Tyrosine protein kinases specific active-site signature. 128 140 - T 17-03-2017 IPR008266 Tyrosine-protein kinase, active site GO:0004672|GO:0006468 SHXM_RS04850 9ca495ac7def8423ad537b5decc2aeb7 652 ProSitePatterns PS00107 Protein kinases ATP-binding region signature. 18 41 - T 17-03-2017 IPR017441 Protein kinase, ATP binding site GO:0005524 SHXM_RS04850 9ca495ac7def8423ad537b5decc2aeb7 652 Gene3D G3DSA:1.10.510.10 76 259 1.5E-46 T 17-03-2017 SHXM_RS04850 9ca495ac7def8423ad537b5decc2aeb7 652 Pfam PF00069 Protein kinase domain 14 257 1.3E-45 T 17-03-2017 IPR000719 Protein kinase domain GO:0004672|GO:0005524|GO:0006468 SHXM_RS28570 e09832f1b3b36e1cf7d85f4938eadcbf 401 SUPERFAMILY SSF48230 283 376 4.21E-50 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS28570 e09832f1b3b36e1cf7d85f4938eadcbf 401 SUPERFAMILY SSF48230 43 253 4.21E-50 T 17-03-2017 IPR008929 Chondroitin AC/alginate lyase Reactome: R-HSA-2022923 SHXM_RS28570 e09832f1b3b36e1cf7d85f4938eadcbf 401 Gene3D G3DSA:1.50.10.110 48 383 1.7E-43 T 17-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SHXM_RS28570 e09832f1b3b36e1cf7d85f4938eadcbf 401 Pfam PF05426 Alginate lyase 110 330 1.4E-15 T 17-03-2017 IPR008397 Alginate lyase domain GO:0016829|GO:0042597 KEGG: 00051+4.2.2.3|MetaCyc: PWY-6986 SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 ProSitePatterns PS00908 Mandelate racemase / muconate lactonizing enzyme family signature 1. 88 113 - T 17-03-2017 IPR018110 Mandelate racemase/muconate lactonizing enzyme, conserved site GO:0009063 SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 SUPERFAMILY SSF54826 12 115 7.69E-33 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 Gene3D G3DSA:3.30.390.10 5 122 1.6E-49 T 17-03-2017 IPR029017 Enolase N-terminal domain-like KEGG: 00010+4.2.1.11|KEGG: 00680+4.2.1.11|MetaCyc: PWY-1042|MetaCyc: PWY-1622|MetaCyc: PWY-2221|MetaCyc: PWY-5484|MetaCyc: PWY-5723|MetaCyc: PWY-6142|MetaCyc: PWY-6886|MetaCyc: PWY-6901|MetaCyc: PWY-7003|MetaCyc: PWY-7124|MetaCyc: PWY-7218 SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 Gene3D G3DSA:3.20.20.120 123 369 1.8E-82 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 Pfam PF13378 Enolase C-terminal domain-like 136 381 5.5E-47 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 SUPERFAMILY SSF51604 101 390 1.83E-74 T 17-03-2017 IPR029065 Enolase C-terminal domain-like SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 SMART SM00922 131 261 8.2E-18 T 17-03-2017 IPR013342 Mandelate racemase/muconate lactonizing enzyme, C-terminal SHXM_RS05955 a03b7ae86d3040a7ce6033318f604bfd 406 Pfam PF02746 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain 18 113 1.7E-32 T 17-03-2017 IPR013341 Mandelate racemase/muconate lactonizing enzyme, N-terminal domain SHXM_RS44905 f0f41fb7379a8c6f748c5122a7936618 561 Pfam PF07905 Purine catabolism regulatory protein-like family 35 156 2.2E-35 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS44905 f0f41fb7379a8c6f748c5122a7936618 561 Pfam PF13556 PucR C-terminal helix-turn-helix domain 490 547 3.6E-14 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS01130 ca40df8e722de6ddbeda121ebafd10bd 68 Gene3D G3DSA:3.40.50.1820 20 65 9.6E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01130 ca40df8e722de6ddbeda121ebafd10bd 68 SUPERFAMILY SSF53474 20 66 2.02E-6 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS15885 239f1bd2f9346a508654aa239e4b4b0e 124 SUPERFAMILY SSF54534 16 124 1.81E-37 T 17-03-2017 SHXM_RS15885 239f1bd2f9346a508654aa239e4b4b0e 124 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 30 121 9.3E-30 T 17-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SHXM_RS15885 239f1bd2f9346a508654aa239e4b4b0e 124 Gene3D G3DSA:3.10.50.40 13 124 2.5E-39 T 17-03-2017 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 Pfam PF01252 Signal peptidase (SPase) II 46 183 3.9E-29 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 164 180 1.0E-14 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 126 141 1.0E-14 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 PRINTS PR00781 Lipoprotein signal peptidase family (A8) signature 84 92 1.0E-14 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 ProSitePatterns PS00855 Signal peptidases II signature. 129 141 - T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 TIGRFAM TIGR00077 lspA: signal peptidase II 42 183 1.6E-21 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS18515 1510aba480cecc68c8d9cd7bebe343ba 195 Hamap MF_00161 Lipoprotein signal peptidase [lspA]. 37 189 14.464 T 17-03-2017 IPR001872 Peptidase A8, signal peptidase II GO:0004190|GO:0006508|GO:0016020 SHXM_RS02745 0f933158c03ce16a8bc6ae88b07eb70b 173 Gene3D G3DSA:2.40.128.110 13 171 2.7E-39 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS02745 0f933158c03ce16a8bc6ae88b07eb70b 173 SMART SM00867 16 172 6.2E-36 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS02745 0f933158c03ce16a8bc6ae88b07eb70b 173 Pfam PF04264 YceI-like domain 17 171 2.4E-31 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS02745 0f933158c03ce16a8bc6ae88b07eb70b 173 SUPERFAMILY SSF101874 13 171 1.29E-35 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS10350 f0d710e20fd174ef94307f8077676b67 76 Gene3D G3DSA:3.40.50.720 10 75 2.9E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10350 f0d710e20fd174ef94307f8077676b67 76 SUPERFAMILY SSF51735 11 76 5.72E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10350 f0d710e20fd174ef94307f8077676b67 76 Pfam PF13380 CoA binding domain 11 72 1.4E-16 T 17-03-2017 IPR003781 CoA-binding GO:0048037 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 149 165 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 285 296 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 303 330 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 331 346 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 361 372 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 102 113 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 166 181 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 203 225 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00359 B-class P450 signature 352 361 1.9E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 354 363 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 Gene3D G3DSA:1.10.630.10 20 413 1.2E-123 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 SUPERFAMILY SSF48264 25 412 3.67E-93 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 Pfam PF00067 Cytochrome P450 212 379 2.2E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00385 P450 superfamily signature 352 361 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00385 P450 superfamily signature 361 372 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00385 P450 superfamily signature 285 296 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS19940 e5e8ca8ad549e20a55d7354da34cd0a7 414 PRINTS PR00385 P450 superfamily signature 248 265 1.1E-7 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS50270 761e9d01c52087f664a671622a985ca4 389 Hamap MF_01270 Anhydro-N-acetylmuramic acid kinase [anmK]. 1 368 35.515 T 17-03-2017 IPR005338 Anhydro-N-acetylmuramic acid kinase GO:0005524|GO:0006040|GO:0009254|GO:0016773 KEGG: 00040+2.7.1.17 SHXM_RS50270 761e9d01c52087f664a671622a985ca4 389 Gene3D G3DSA:3.30.420.40 145 328 4.9E-59 T 17-03-2017 SHXM_RS50270 761e9d01c52087f664a671622a985ca4 389 SUPERFAMILY SSF53067 71 110 6.09E-15 T 17-03-2017 SHXM_RS50270 761e9d01c52087f664a671622a985ca4 389 SUPERFAMILY SSF53067 1 35 6.09E-15 T 17-03-2017 SHXM_RS50270 761e9d01c52087f664a671622a985ca4 389 SUPERFAMILY SSF53067 143 321 6.09E-15 T 17-03-2017 SHXM_RS50270 761e9d01c52087f664a671622a985ca4 389 Pfam PF03702 Uncharacterised protein family (UPF0075) 1 367 1.7E-135 T 17-03-2017 IPR005338 Anhydro-N-acetylmuramic acid kinase GO:0005524|GO:0006040|GO:0009254|GO:0016773 KEGG: 00040+2.7.1.17 SHXM_RS22275 c4aaee0a7676d806c14904bebfbcdcdd 294 Gene3D G3DSA:3.40.50.300 21 253 1.3E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22275 c4aaee0a7676d806c14904bebfbcdcdd 294 SUPERFAMILY SSF52540 23 246 1.46E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22275 c4aaee0a7676d806c14904bebfbcdcdd 294 Pfam PF00005 ABC transporter 40 194 6.7E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22275 c4aaee0a7676d806c14904bebfbcdcdd 294 SMART SM00382 49 241 7.8E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS35105 1a81a72eedf8d2e7eba964716fa2600d 163 Pfam PF13581 Histidine kinase-like ATPase domain 18 134 6.6E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35105 1a81a72eedf8d2e7eba964716fa2600d 163 Gene3D G3DSA:3.30.565.10 21 149 1.3E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS35105 1a81a72eedf8d2e7eba964716fa2600d 163 SUPERFAMILY SSF55874 38 153 9.7E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS17780 071c543d4e6566b9cd7cdcd95d309eff 608 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 308 599 7.8E-16 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS17780 071c543d4e6566b9cd7cdcd95d309eff 608 SUPERFAMILY SSF56219 305 605 3.93E-31 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS17780 071c543d4e6566b9cd7cdcd95d309eff 608 Gene3D G3DSA:3.60.10.10 305 605 5.5E-32 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS18025 b646a1ad9cce325ecf86313f6ba45e49 220 Pfam PF14273 Domain of unknown function (DUF4360) 36 215 4.3E-69 T 17-03-2017 IPR025649 Protein of unknown function DUF4360 SHXM_RS34810 8752e990fcdae138df1f04cbc510ad7b 206 Gene3D G3DSA:3.40.109.10 19 204 8.0E-43 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS34810 8752e990fcdae138df1f04cbc510ad7b 206 SUPERFAMILY SSF55469 22 204 1.44E-42 T 17-03-2017 IPR000415 Nitroreductase-like GO:0016491 Reactome: R-HSA-209968 SHXM_RS34810 8752e990fcdae138df1f04cbc510ad7b 206 Pfam PF00881 Nitroreductase family 27 184 1.1E-17 T 17-03-2017 IPR029479 Nitroreductase Reactome: R-HSA-209968 SHXM_RS02055 779832f730381d33d5b566adf3599af0 281 Gene3D G3DSA:3.40.50.300 19 273 8.7E-73 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02055 779832f730381d33d5b566adf3599af0 281 SUPERFAMILY SSF52540 20 271 2.38E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS02055 779832f730381d33d5b566adf3599af0 281 SMART SM00382 49 249 2.8E-15 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02055 779832f730381d33d5b566adf3599af0 281 Pfam PF00005 ABC transporter 41 199 6.5E-24 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS25870 e81f13a296a13899f081b8ba0d423e7b 488 Gene3D G3DSA:3.40.50.2000 9 277 5.0E-61 T 17-03-2017 SHXM_RS25870 e81f13a296a13899f081b8ba0d423e7b 488 Pfam PF00982 Glycosyltransferase family 20 11 485 3.4E-105 T 17-03-2017 IPR001830 Glycosyl transferase, family 20 GO:0003824|GO:0005992 SHXM_RS25870 e81f13a296a13899f081b8ba0d423e7b 488 SUPERFAMILY SSF53756 9 488 1.88E-109 T 17-03-2017 SHXM_RS25870 e81f13a296a13899f081b8ba0d423e7b 488 Gene3D G3DSA:3.40.50.2000 278 470 8.8E-58 T 17-03-2017 SHXM_RS33850 8503cf148f07ddf47876b69549a5f195 308 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 307 1.1E-35 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33850 8503cf148f07ddf47876b69549a5f195 308 SUPERFAMILY SSF161098 91 294 2.49E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33850 8503cf148f07ddf47876b69549a5f195 308 Gene3D G3DSA:1.10.3720.10 89 302 6.1E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS41735 567646c755e88a1c84d3eff0dcf811fa 188 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 57 5.9E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41735 567646c755e88a1c84d3eff0dcf811fa 188 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 9.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41735 567646c755e88a1c84d3eff0dcf811fa 188 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 9.9E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41735 567646c755e88a1c84d3eff0dcf811fa 188 Gene3D G3DSA:1.10.357.10 55 182 4.0E-12 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41735 567646c755e88a1c84d3eff0dcf811fa 188 SUPERFAMILY SSF46689 4 74 1.8E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41735 567646c755e88a1c84d3eff0dcf811fa 188 Gene3D G3DSA:1.10.10.60 9 54 2.4E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49115 0b9f7f312dde8aa6b05d9ecc4eade988 468 Gene3D G3DSA:1.20.1250.20 18 215 6.8E-23 T 17-03-2017 SHXM_RS49115 0b9f7f312dde8aa6b05d9ecc4eade988 468 SUPERFAMILY SSF103473 264 460 8.63E-45 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49115 0b9f7f312dde8aa6b05d9ecc4eade988 468 SUPERFAMILY SSF103473 12 226 8.63E-45 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS49115 0b9f7f312dde8aa6b05d9ecc4eade988 468 Pfam PF07690 Major Facilitator Superfamily 27 422 2.1E-32 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS49115 0b9f7f312dde8aa6b05d9ecc4eade988 468 Gene3D G3DSA:1.20.1250.20 291 458 1.0E-13 T 17-03-2017 SHXM_RS49215 0c9f499b4c84734aa0aca8cf626d904d 72 Pfam PF13592 Winged helix-turn helix 1 38 7.9E-12 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS37835 ee09bd0cafb16ef49d685a1681f39f94 120 Gene3D G3DSA:3.40.1260.10 35 110 3.3E-6 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS37835 ee09bd0cafb16ef49d685a1681f39f94 120 Pfam PF02635 DsrE/DsrF-like family 17 111 4.6E-7 T 17-03-2017 IPR003787 Sulphur relay, DsrE/F-like protein SHXM_RS37835 ee09bd0cafb16ef49d685a1681f39f94 120 SUPERFAMILY SSF75169 14 111 1.96E-12 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS12805 cb2649d27f8c0fcc80fc7035168284d3 215 SUPERFAMILY SSF55729 7 172 2.28E-36 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12805 cb2649d27f8c0fcc80fc7035168284d3 215 Gene3D G3DSA:3.40.630.30 8 192 1.8E-45 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS12805 cb2649d27f8c0fcc80fc7035168284d3 215 Pfam PF13302 Acetyltransferase (GNAT) domain 14 154 1.3E-24 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 Pfam PF00248 Aldo/keto reductase family 24 260 9.0E-54 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 ProSitePatterns PS00062 Aldo/keto reductase family signature 2. 125 142 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 SUPERFAMILY SSF51430 7 268 1.44E-100 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 ProSitePatterns PS00798 Aldo/keto reductase family signature 1. 41 58 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 ProSitePatterns PS00063 Aldo/keto reductase family putative active site signature. 229 244 - T 17-03-2017 IPR018170 Aldo/keto reductase, conserved site GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 PRINTS PR00069 Aldo-keto reductase signature 37 61 5.5E-50 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 PRINTS PR00069 Aldo-keto reductase signature 125 142 5.5E-50 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 PRINTS PR00069 Aldo-keto reductase signature 196 220 5.5E-50 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 PRINTS PR00069 Aldo-keto reductase signature 93 111 5.5E-50 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 PRINTS PR00069 Aldo-keto reductase signature 159 188 5.5E-50 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS42115 ea97301dd7b61510dea17fce03b154ce 274 Gene3D G3DSA:3.20.20.100 6 271 5.8E-110 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS29980 81a215802c99755b919d2096884c67dd 105 Pfam PF10724 Protein of unknown function (DUF2516) 2 83 1.3E-29 T 17-03-2017 IPR019662 Protein of unknown function DUF2516 SHXM_RS45695 7ce48a2ede870f3bb406193454e05c20 306 Pfam PF01261 Xylose isomerase-like TIM barrel 20 254 5.2E-27 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45695 7ce48a2ede870f3bb406193454e05c20 306 SUPERFAMILY SSF51658 1 303 9.56E-51 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45695 7ce48a2ede870f3bb406193454e05c20 306 Gene3D G3DSA:3.20.20.150 1 300 2.1E-64 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS45695 7ce48a2ede870f3bb406193454e05c20 306 Pfam PF07582 AP endonuclease family 2 C terminus 256 281 8.0E-6 T 17-03-2017 IPR011418 AP endonuclease, family 2, C-terminal SHXM_RS45120 d1d5a9ed2ec42fb24c355213fd7fdfb1 255 SUPERFAMILY SSF53474 21 252 5.54E-40 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS45120 d1d5a9ed2ec42fb24c355213fd7fdfb1 255 PRINTS PR00111 Alpha/beta hydrolase fold signature 112 125 7.8E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45120 d1d5a9ed2ec42fb24c355213fd7fdfb1 255 PRINTS PR00111 Alpha/beta hydrolase fold signature 98 111 7.8E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45120 d1d5a9ed2ec42fb24c355213fd7fdfb1 255 PRINTS PR00111 Alpha/beta hydrolase fold signature 53 68 7.8E-10 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45120 d1d5a9ed2ec42fb24c355213fd7fdfb1 255 Pfam PF00561 alpha/beta hydrolase fold 29 134 5.0E-18 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS45120 d1d5a9ed2ec42fb24c355213fd7fdfb1 255 Gene3D G3DSA:3.40.50.1820 23 252 3.1E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40190 9bc75be44bc8b137976468a33db5e37d 155 Pfam PF13302 Acetyltransferase (GNAT) domain 32 134 1.5E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS40190 9bc75be44bc8b137976468a33db5e37d 155 Gene3D G3DSA:3.40.630.30 45 141 4.7E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS40190 9bc75be44bc8b137976468a33db5e37d 155 SUPERFAMILY SSF55729 19 146 3.9E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS09595 cf56ac3512160aa321f9c0bd0f591c77 529 Pfam PF00665 Integrase core domain 140 269 1.4E-14 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS09595 cf56ac3512160aa321f9c0bd0f591c77 529 SUPERFAMILY SSF53098 146 308 1.74E-6 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 Pfam PF05147 Lanthionine synthetase C-like protein 37 351 4.0E-29 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 SMART SM01260 32 405 4.6E-33 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 SUPERFAMILY SSF158745 36 407 6.28E-49 T 17-03-2017 SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01950 LanC-like protein superfamily signature 143 158 3.9E-16 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01950 LanC-like protein superfamily signature 284 304 3.9E-16 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01950 LanC-like protein superfamily signature 35 53 3.9E-16 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01950 LanC-like protein superfamily signature 334 347 3.9E-16 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01950 LanC-like protein superfamily signature 213 229 3.9E-16 T 17-03-2017 IPR007822 Lanthionine synthetase C-like SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 284 307 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 36 51 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 210 234 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 142 158 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 333 353 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 234 254 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS01190 db6851b388cf9f776524d8352be546c4 408 PRINTS PR01955 Frankia sp. LanC-like protein signature 80 96 3.0E-38 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS10465 d4870e3a0a3df72dd744f889cad67f8e 281 SUPERFAMILY SSF53335 25 236 1.57E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10465 d4870e3a0a3df72dd744f889cad67f8e 281 Gene3D G3DSA:3.40.50.150 14 265 4.2E-67 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10900 5b65218299ed679e63873f0570908edc 251 SUPERFAMILY SSF53474 20 235 4.44E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10900 5b65218299ed679e63873f0570908edc 251 Gene3D G3DSA:3.40.50.1820 25 123 2.1E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS10900 5b65218299ed679e63873f0570908edc 251 Gene3D G3DSA:3.40.50.1820 167 226 2.1E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS04185 fb6bacabcd58e6aa59657b617bebd248 563 Pfam PF02366 Dolichyl-phosphate-mannose-protein mannosyltransferase 63 281 4.4E-14 T 17-03-2017 IPR003342 Glycosyl transferase family 39/83 GO:0000030|GO:0006493|GO:0016020 Reactome: R-HSA-5173105 SHXM_RS14060 887eb4f0e600591a990eee886cb02a85 136 SUPERFAMILY SSF54427 4 124 5.09E-18 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS14060 887eb4f0e600591a990eee886cb02a85 136 Gene3D G3DSA:3.10.450.50 3 123 6.0E-17 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS14060 887eb4f0e600591a990eee886cb02a85 136 Pfam PF07858 Limonene-1,2-epoxide hydrolase catalytic domain 6 123 3.0E-11 T 17-03-2017 IPR013100 Limonene-1,2-epoxide hydrolase SHXM_RS08100 5fc22ac0102ed307a9e1658bea09fd9f 257 SUPERFAMILY SSF51658 4 243 1.93E-25 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS08100 5fc22ac0102ed307a9e1658bea09fd9f 257 Pfam PF01261 Xylose isomerase-like TIM barrel 21 190 1.0E-18 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS08100 5fc22ac0102ed307a9e1658bea09fd9f 257 Gene3D G3DSA:3.20.20.150 3 198 2.8E-34 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS49110 a7519088280bcb22fa9a6068596fda9f 146 SUPERFAMILY SSF46785 8 145 1.6E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49110 a7519088280bcb22fa9a6068596fda9f 146 SMART SM00347 28 129 1.1E-17 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS49110 a7519088280bcb22fa9a6068596fda9f 146 Pfam PF01047 MarR family 35 92 2.5E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS49110 a7519088280bcb22fa9a6068596fda9f 146 Gene3D G3DSA:1.10.287.100 100 144 1.1E-11 T 17-03-2017 IPR013028 Transcription factor IIA, alpha subunit, N-terminal GO:0006367 SHXM_RS49110 a7519088280bcb22fa9a6068596fda9f 146 Gene3D G3DSA:1.10.10.10 35 97 1.8E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36955 0a4f445ddd9b296b338b21fbf6fb09f6 603 Pfam PF13360 PQQ-like domain 244 509 5.0E-7 T 17-03-2017 IPR002372 Pyrrolo-quinoline quinone repeat SHXM_RS36955 0a4f445ddd9b296b338b21fbf6fb09f6 603 SUPERFAMILY SSF63829 403 584 7.85E-6 T 17-03-2017 SHXM_RS36955 0a4f445ddd9b296b338b21fbf6fb09f6 603 SUPERFAMILY SSF63829 250 315 7.85E-6 T 17-03-2017 SHXM_RS41790 3612de5d55a514d99b4223c06bbc4975 221 Pfam PF04268 Sarcosine oxidase, gamma subunit family 61 212 2.3E-28 T 17-03-2017 IPR007375 Sarcosine oxidase, gamma subunit KEGG: 00260+1.5.3.1|MetaCyc: PWY-3661|MetaCyc: PWY-4722 SHXM_RS41790 3612de5d55a514d99b4223c06bbc4975 221 SUPERFAMILY SSF103025 88 215 7.85E-16 T 17-03-2017 SHXM_RS20520 ac890e8f496d3f8822bde46fcf956e19 146 SUPERFAMILY SSF54593 19 136 9.26E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS20520 ac890e8f496d3f8822bde46fcf956e19 146 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 20 132 3.3E-9 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS20520 ac890e8f496d3f8822bde46fcf956e19 146 Gene3D G3DSA:3.10.180.10 20 135 1.3E-19 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS12925 3cc2048b05b6626d0a4c58f15174e821 133 Pfam PF04343 Protein of unknown function, DUF488 19 127 3.9E-28 T 17-03-2017 IPR007438 Protein of unknown function DUF488 SHXM_RS03565 ddb95c506946f21287216c2f3104d4d5 358 SUPERFAMILY SSF111331 169 317 1.7E-61 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS03565 ddb95c506946f21287216c2f3104d4d5 358 SUPERFAMILY SSF111331 6 134 1.7E-61 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS03565 ddb95c506946f21287216c2f3104d4d5 358 Gene3D G3DSA:2.60.200.30 172 290 1.9E-30 T 17-03-2017 IPR017437 ATP-NAD kinase, PpnK-type, all-beta GO:0003951|GO:0008152|GO:0019674 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS03565 ddb95c506946f21287216c2f3104d4d5 358 Hamap MF_00361 NAD kinase [nadK]. 4 317 27.594 T 17-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS03565 ddb95c506946f21287216c2f3104d4d5 358 Pfam PF01513 ATP-NAD kinase 53 301 4.6E-43 T 17-03-2017 IPR002504 NAD kinase GO:0003951|GO:0006741|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS03565 ddb95c506946f21287216c2f3104d4d5 358 Gene3D G3DSA:3.40.50.10330 3 133 7.5E-25 T 17-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS18510 796fca7aa33b6b74ba1a9029c5939960 313 ProSitePatterns PS01129 Rlu family of pseudouridine synthase signature. 139 153 - T 17-03-2017 IPR006224 Pseudouridine synthase, RluC/RluD, conserved site GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS18510 796fca7aa33b6b74ba1a9029c5939960 313 SUPERFAMILY SSF55120 82 309 6.37E-70 T 17-03-2017 IPR020103 Pseudouridine synthase, catalytic domain GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS18510 796fca7aa33b6b74ba1a9029c5939960 313 Pfam PF00849 RNA pseudouridylate synthase 93 247 1.6E-32 T 17-03-2017 IPR006145 Pseudouridine synthase, RsuA/RluB/C/D/E/F GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS18510 796fca7aa33b6b74ba1a9029c5939960 313 Gene3D G3DSA:3.10.290.10 19 61 7.8E-8 T 17-03-2017 IPR002942 RNA-binding S4 domain GO:0003723 SHXM_RS18510 796fca7aa33b6b74ba1a9029c5939960 313 SUPERFAMILY SSF55174 19 69 2.16E-6 T 17-03-2017 SHXM_RS18510 796fca7aa33b6b74ba1a9029c5939960 313 TIGRFAM TIGR00005 rluA_subfam: pseudouridine synthase, RluA family 17 306 4.6E-85 T 17-03-2017 IPR006225 Pseudouridine synthase, RluC/RluD GO:0001522|GO:0003723|GO:0009451|GO:0009982 SHXM_RS03270 3364097c261709d729bfde9958e90706 273 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 93 256 5.0E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03270 3364097c261709d729bfde9958e90706 273 Gene3D G3DSA:1.10.3720.10 72 261 1.6E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03270 3364097c261709d729bfde9958e90706 273 SUPERFAMILY SSF161098 74 252 3.79E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS34620 4be8a261013056334025cf18332db7a2 322 Pfam PF00781 Diacylglycerol kinase catalytic domain 2 118 7.0E-26 T 17-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SHXM_RS34620 4be8a261013056334025cf18332db7a2 322 SMART SM00046 2 133 2.1E-9 T 17-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SHXM_RS34620 4be8a261013056334025cf18332db7a2 322 SUPERFAMILY SSF111331 1 322 1.02E-51 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 ProSitePatterns PS00957 NAD-dependent glycerol-3-phosphate dehydrogenase signature. 188 209 - T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 Pfam PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 5 160 4.2E-50 T 17-03-2017 IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal GO:0016616|GO:0046168|GO:0051287|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 Gene3D G3DSA:1.10.1040.10 180 326 4.5E-55 T 17-03-2017 IPR013328 6-phosphogluconate dehydrogenase, domain 2 GO:0016491|GO:0055114 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 238 255 4.7E-47 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 6 23 4.7E-47 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 173 197 4.7E-47 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 198 222 4.7E-47 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 56 83 4.7E-47 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PRINTS PR00077 NAD-dependent glycerol-3-phosphate dehydrogenase signature 133 153 4.7E-47 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 PIRSF PIRSF000114 1 332 1.1E-99 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 Hamap MF_00394 Glycerol-3-phosphate dehydrogenase [NAD(P)+] [gpsA]. 2 322 37.254 T 17-03-2017 IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent GO:0004367|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 Gene3D G3DSA:3.40.50.720 4 179 6.0E-63 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 Pfam PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 180 317 1.3E-49 T 17-03-2017 IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal GO:0004367|GO:0005975|GO:0055114 KEGG: 00564+1.1.1.94|MetaCyc: PWY-5667|MetaCyc: PWY-5981|Reactome: R-HSA-1483166|Reactome: R-HSA-75109 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 SUPERFAMILY SSF48179 179 331 1.7E-54 T 17-03-2017 IPR008927 6-phosphogluconate dehydrogenase C-terminal domain-like GO:0055114 SHXM_RS36385 ee0902ced3c073c935f4729052d6a600 333 SUPERFAMILY SSF51735 4 179 9.36E-52 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS13450 06bc6d06fa3ed506280f01d8cbefce99 203 Gene3D G3DSA:3.90.79.10 28 189 2.9E-48 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS13450 06bc6d06fa3ed506280f01d8cbefce99 203 TIGRFAM TIGR02150 IPP_isom_1: isopentenyl-diphosphate delta-isomerase 30 185 2.3E-34 T 17-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 SHXM_RS13450 06bc6d06fa3ed506280f01d8cbefce99 203 Hamap MF_00202 Isopentenyl-diphosphate Delta-isomerase [idi]. 26 197 31.407 T 17-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 SHXM_RS13450 06bc6d06fa3ed506280f01d8cbefce99 203 SUPERFAMILY SSF55811 28 188 3.93E-43 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS13450 06bc6d06fa3ed506280f01d8cbefce99 203 Pfam PF00293 NUDIX domain 53 173 3.6E-24 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS13450 06bc6d06fa3ed506280f01d8cbefce99 203 PIRSF PIRSF018427 11 201 7.8E-50 T 17-03-2017 IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1 GO:0004452|GO:0008299 KEGG: 00900+5.3.3.2|MetaCyc: PWY-5123|MetaCyc: PWY-6174|MetaCyc: PWY-6383|MetaCyc: PWY-6859|MetaCyc: PWY-7102|MetaCyc: PWY-7391|MetaCyc: PWY-7524|MetaCyc: PWY-7560|MetaCyc: PWY-922|Reactome: R-HSA-191273 SHXM_RS26735 2e16cc1b951e64c093fbc6eec37e753a 192 Pfam PF01966 HD domain 25 110 3.8E-11 T 17-03-2017 IPR006674 HD domain SHXM_RS26735 2e16cc1b951e64c093fbc6eec37e753a 192 SUPERFAMILY SSF109604 4 98 3.62E-14 T 17-03-2017 SHXM_RS26735 2e16cc1b951e64c093fbc6eec37e753a 192 Gene3D G3DSA:1.10.3210.10 9 103 1.7E-12 T 17-03-2017 IPR006674 HD domain SHXM_RS26735 2e16cc1b951e64c093fbc6eec37e753a 192 TIGRFAM TIGR00277 HDIG: HDIG domain 27 96 2.4E-7 T 17-03-2017 IPR006675 HDIG domain SHXM_RS03165 c580fd567d5026707a158533527b0a72 384 Pfam PF10228 Uncharacterised conserved protein (DUF2228) 135 215 3.1E-9 T 17-03-2017 IPR019361 Protein of unknown function DUF2228, C2H2, APLF-like SHXM_RS49295 5c56f0e78fed5b1742f5bbfae4558ca7 126 SUPERFAMILY SSF46689 3 89 9.14E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS49295 5c56f0e78fed5b1742f5bbfae4558ca7 126 Pfam PF13592 Winged helix-turn helix 59 117 2.1E-14 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS25995 3e1f56a28512ba46b2b49b88f02a8da4 266 Pfam PF00483 Nucleotidyl transferase 21 247 2.3E-23 T 17-03-2017 IPR005835 Nucleotidyl transferase domain GO:0009058|GO:0016779 SHXM_RS25995 3e1f56a28512ba46b2b49b88f02a8da4 266 Gene3D G3DSA:3.90.550.10 19 250 2.8E-53 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS25995 3e1f56a28512ba46b2b49b88f02a8da4 266 SUPERFAMILY SSF53448 19 254 5.42E-53 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS37735 5f799ff0fad5ced11744f79505349615 257 Pfam PF00975 Thioesterase domain 25 246 8.2E-44 T 17-03-2017 IPR001031 Thioesterase GO:0009058|GO:0016788 Reactome: R-HSA-75105 SHXM_RS37735 5f799ff0fad5ced11744f79505349615 257 SUPERFAMILY SSF53474 4 249 2.83E-45 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS37735 5f799ff0fad5ced11744f79505349615 257 Gene3D G3DSA:3.40.50.1820 11 249 1.1E-28 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS22780 98ea2b6a70cca60d1d4c450333cf31ab 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 119 289 1.1E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22780 98ea2b6a70cca60d1d4c450333cf31ab 304 SUPERFAMILY SSF161098 38 304 2.9E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22780 98ea2b6a70cca60d1d4c450333cf31ab 304 Gene3D G3DSA:1.10.3720.10 38 289 1.4E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38925 3d32c8b0019bc4d119f16f2627dbb816 253 Pfam PF04228 Putative neutral zinc metallopeptidase 122 244 1.2E-8 T 17-03-2017 IPR007343 Uncharacterised protein family, zinc metallopeptidase putative SHXM_RS38925 3d32c8b0019bc4d119f16f2627dbb816 253 SUPERFAMILY SSF55486 47 202 5.66E-9 T 17-03-2017 SHXM_RS09950 9988c26a48173c813f06efd9b5110dff 316 Gene3D G3DSA:3.60.15.10 84 310 1.4E-27 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS09950 9988c26a48173c813f06efd9b5110dff 316 SUPERFAMILY SSF56281 84 310 5.77E-27 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS09950 9988c26a48173c813f06efd9b5110dff 316 SMART SM00849 85 306 5.1E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS09950 9988c26a48173c813f06efd9b5110dff 316 Pfam PF00753 Metallo-beta-lactamase superfamily 87 275 7.0E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS40875 b98d0b1a50595bcd572e53840eab798c 253 Pfam PF09490 Probable cobalt transporter subunit (CbtA) 7 231 2.9E-67 T 17-03-2017 IPR012666 Cobalt transporter subunit CbtA, putative SHXM_RS22950 c8fc6da3c393df4a2a7ac3c6adf2c540 406 Pfam PF04261 Dyp-type peroxidase family 50 394 4.3E-104 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS22950 c8fc6da3c393df4a2a7ac3c6adf2c540 406 TIGRFAM TIGR01412 tat_substr_1: Tat-translocated enzyme 4 405 4.7E-146 T 17-03-2017 IPR006313 Deferrochelatase/peroxidase EfeB GO:0004601|GO:0015684|GO:0020037|GO:0033212 SHXM_RS22950 c8fc6da3c393df4a2a7ac3c6adf2c540 406 SUPERFAMILY SSF54909 43 400 2.32E-94 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS22950 c8fc6da3c393df4a2a7ac3c6adf2c540 406 TIGRFAM TIGR01413 Dyp_perox_fam: Dyp-type peroxidase family 50 394 3.8E-95 T 17-03-2017 IPR006314 Dyp-type peroxidase GO:0004601|GO:0020037|GO:0055114 SHXM_RS16505 e5350010c3929ade73347ac3a72e719c 240 SUPERFAMILY SSF46689 14 95 3.84E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS16505 e5350010c3929ade73347ac3a72e719c 240 Gene3D G3DSA:1.10.357.10 28 236 4.5E-25 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS16505 e5350010c3929ade73347ac3a72e719c 240 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 75 4.5E-12 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16505 e5350010c3929ade73347ac3a72e719c 240 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 50 73 4.1E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS16505 e5350010c3929ade73347ac3a72e719c 240 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 42 4.1E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS11790 dc90e8f0be906c66e7f72b863b697fc8 214 Pfam PF04299 Putative FMN-binding domain 1 166 3.7E-53 T 17-03-2017 IPR007396 Transcriptional regulator PAI 2-type SHXM_RS11790 dc90e8f0be906c66e7f72b863b697fc8 214 Gene3D G3DSA:2.30.110.10 1 206 2.9E-66 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS11790 dc90e8f0be906c66e7f72b863b697fc8 214 SUPERFAMILY SSF50475 13 191 2.13E-32 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS11790 dc90e8f0be906c66e7f72b863b697fc8 214 PIRSF PIRSF010372 1 210 2.8E-61 T 17-03-2017 IPR007396 Transcriptional regulator PAI 2-type SHXM_RS47295 d430ff15fc755be1269d75bcd9708e67 212 Gene3D G3DSA:2.40.100.10 88 211 5.8E-38 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS47295 d430ff15fc755be1269d75bcd9708e67 212 SMART SM00796 6 199 1.3E-58 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS47295 d430ff15fc755be1269d75bcd9708e67 212 SUPERFAMILY SSF50891 88 211 4.55E-35 T 17-03-2017 IPR029000 Cyclophilin-like domain SHXM_RS47295 d430ff15fc755be1269d75bcd9708e67 212 Pfam PF02682 Allophanate hydrolase subunit 1 9 197 1.8E-53 T 17-03-2017 IPR003833 Carboxyltransferase domain, subdomain C and D SHXM_RS36060 58205c02d3947b7680f67cb66ae0e393 404 SUPERFAMILY SSF53756 1 398 4.4E-85 T 17-03-2017 SHXM_RS36060 58205c02d3947b7680f67cb66ae0e393 404 Gene3D G3DSA:3.40.50.2000 1 243 4.6E-58 T 17-03-2017 SHXM_RS36060 58205c02d3947b7680f67cb66ae0e393 404 Gene3D G3DSA:3.40.50.2000 244 382 4.3E-13 T 17-03-2017 SHXM_RS36060 58205c02d3947b7680f67cb66ae0e393 404 Pfam PF03033 Glycosyltransferase family 28 N-terminal domain 3 133 4.4E-7 T 17-03-2017 IPR004276 Glycosyltransferase family 28, N-terminal domain GO:0005975|GO:0016758|GO:0030259 KEGG: 00052+2.4.1.22|KEGG: 00550+2.4.1.227|MetaCyc: PWY-5265|MetaCyc: PWY-6385|MetaCyc: PWY-6470|MetaCyc: PWY-6471 SHXM_RS36060 58205c02d3947b7680f67cb66ae0e393 404 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 293 379 9.3E-6 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS16065 d1d5c338cfeab25c38bc484b12c8353d 196 Pfam PF11290 Protein of unknown function (DUF3090) 7 186 1.2E-67 T 17-03-2017 IPR021441 Protein of unknown function DUF3090 SHXM_RS16065 d1d5c338cfeab25c38bc484b12c8353d 196 TIGRFAM TIGR03847 TIGR03847: conserved hypothetical protein 5 190 1.2E-77 T 17-03-2017 IPR021441 Protein of unknown function DUF3090 SHXM_RS41220 919e8fe26284310f40ac6af72cf18483 298 Gene3D G3DSA:3.20.20.60 55 286 6.0E-52 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS41220 919e8fe26284310f40ac6af72cf18483 298 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 56 234 3.0E-26 T 17-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 SHXM_RS41220 919e8fe26284310f40ac6af72cf18483 298 SUPERFAMILY SSF51621 54 291 5.58E-52 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS34255 ea9e21b790ae7cbaba3f219e97a360f0 532 Gene3D G3DSA:3.40.50.1820 398 519 1.3E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34255 ea9e21b790ae7cbaba3f219e97a360f0 532 Gene3D G3DSA:3.40.50.1820 86 170 1.3E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34255 ea9e21b790ae7cbaba3f219e97a360f0 532 Gene3D G3DSA:3.40.50.1820 214 334 1.3E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34255 ea9e21b790ae7cbaba3f219e97a360f0 532 SUPERFAMILY SSF53474 211 504 1.22E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34255 ea9e21b790ae7cbaba3f219e97a360f0 532 SUPERFAMILY SSF53474 105 168 1.22E-23 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34255 ea9e21b790ae7cbaba3f219e97a360f0 532 Pfam PF08386 TAP-like protein 427 531 1.7E-32 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS05220 0e63105b5dcaddb0639fecdef3081b0e 150 Gene3D G3DSA:1.10.1660.10 13 132 6.8E-27 T 17-03-2017 SHXM_RS05220 0e63105b5dcaddb0639fecdef3081b0e 150 SUPERFAMILY SSF46955 13 120 6.96E-25 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS05220 0e63105b5dcaddb0639fecdef3081b0e 150 SMART SM00422 13 83 1.5E-14 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS05220 0e63105b5dcaddb0639fecdef3081b0e 150 Pfam PF13411 MerR HTH family regulatory protein 13 82 1.2E-14 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 TIGRFAM TIGR00133 gatB: aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit 16 497 6.5E-141 T 17-03-2017 IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit GO:0016884 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 Pfam PF02637 GatB domain 350 497 8.3E-40 T 17-03-2017 IPR018027 Asn/Gln amidotransferase GO:0016884 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 SUPERFAMILY SSF55931 18 319 8.5E-112 T 17-03-2017 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 Pfam PF02934 GatB/GatE catalytic domain 19 312 4.2E-103 T 17-03-2017 IPR006075 Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic GO:0016874 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 Hamap MF_00121 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B [gatB]. 15 498 35.457 T 17-03-2017 IPR004413 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit GO:0016884 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 Gene3D G3DSA:1.10.10.410 442 497 1.2E-4 T 17-03-2017 IPR023168 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B, C-terminal SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 SMART SM00845 350 497 1.2E-56 T 17-03-2017 IPR018027 Asn/Gln amidotransferase GO:0016884 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 ProSitePatterns PS01234 Glutamyl-tRNA(Gln) amidotransferase subunit B signature. 163 177 - T 17-03-2017 IPR017958 Glutamyl-tRNA(Gln) amidotransferase, subunit B, conserved site GO:0016884 SHXM_RS36105 79637bb2c9f047c7ad582150ae3bcc81 501 SUPERFAMILY SSF89095 351 497 3.79E-24 T 17-03-2017 IPR003789 Aspartyl/glutamyl-tRNA amidotransferase subunit B-related GO:0016884 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 Gene3D G3DSA:3.40.50.720 138 194 7.5E-5 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 181 199 7.4E-8 T 17-03-2017 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 5 24 7.4E-8 T 17-03-2017 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 4 26 3.9E-8 T 17-03-2017 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 181 206 3.9E-8 T 17-03-2017 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 5 215 7.5E-15 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 SUPERFAMILY SSF51905 5 395 2.83E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 Gene3D G3DSA:3.50.50.60 5 137 5.7E-15 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30855 1fc1b0d474936eb3602d899009060898 399 Gene3D G3DSA:3.50.50.60 195 371 2.4E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 Pfam PF10415 Fumarase C C-terminus 413 471 5.4E-20 T 17-03-2017 IPR018951 Fumarase C, C-terminal GO:0006099|GO:0016829 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 SUPERFAMILY SSF48557 15 470 3.14E-146 T 17-03-2017 IPR008948 L-Aspartase-like GO:0003824 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 Gene3D G3DSA:1.10.275.10 14 143 2.6E-51 T 17-03-2017 IPR024083 Fumarase/histidase, N-terminal SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 PRINTS PR00145 Argininosuccinate lyase family signature 180 200 5.7E-5 T 17-03-2017 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 PRINTS PR00145 Argininosuccinate lyase family signature 322 338 5.7E-5 T 17-03-2017 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 ProSitePatterns PS00163 Fumarate lyases signature. 322 331 - T 17-03-2017 IPR020557 Fumarate lyase, conserved site GO:0003824 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 Hamap MF_00743 Fumarate hydratase class II [fumC]. 15 472 81.519 T 17-03-2017 IPR005677 Fumarate hydratase, class II GO:0004333|GO:0006106|GO:0045239 KEGG: 00020+4.2.1.2|KEGG: 00620+4.2.1.2|KEGG: 00720+4.2.1.2|MetaCyc: PWY-5392|MetaCyc: PWY-561|MetaCyc: PWY-5690|MetaCyc: PWY-5913|MetaCyc: PWY-6728|MetaCyc: PWY-6969|MetaCyc: PWY-7254|MetaCyc: PWY-7384|Reactome: R-HSA-71403 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 Gene3D G3DSA:1.10.40.30 413 472 3.4E-21 T 17-03-2017 SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 PRINTS PR00149 Fumarate lyase superfamily signature 276 303 4.5E-32 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 PRINTS PR00149 Fumarate lyase superfamily signature 139 157 4.5E-32 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 PRINTS PR00149 Fumarate lyase superfamily signature 185 203 4.5E-32 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 PRINTS PR00149 Fumarate lyase superfamily signature 322 338 4.5E-32 T 17-03-2017 IPR000362 Fumarate lyase family SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 Pfam PF00206 Lyase 23 347 1.0E-101 T 17-03-2017 IPR022761 Fumarate lyase, N-terminal SHXM_RS33610 c049d56d7577d164ca185ba2e87ef57b 472 Gene3D G3DSA:1.20.200.10 144 408 1.4E-97 T 17-03-2017 SHXM_RS34930 d1424b48b9ed3cd16dc0e039afa5d4b1 462 SUPERFAMILY SSF51905 2 163 9.5E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS34930 d1424b48b9ed3cd16dc0e039afa5d4b1 462 SUPERFAMILY SSF51905 288 363 9.5E-19 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS34930 d1424b48b9ed3cd16dc0e039afa5d4b1 462 Gene3D G3DSA:3.50.50.60 280 362 3.5E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS34930 d1424b48b9ed3cd16dc0e039afa5d4b1 462 Gene3D G3DSA:3.50.50.60 3 169 3.5E-11 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS34930 d1424b48b9ed3cd16dc0e039afa5d4b1 462 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 3 25 3.0E-5 T 17-03-2017 SHXM_RS34930 d1424b48b9ed3cd16dc0e039afa5d4b1 462 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 308 324 3.0E-5 T 17-03-2017 SHXM_RS13860 a3beaf7e61797ffe9daf7334664f9b1e 299 Gene3D G3DSA:3.20.20.100 16 297 1.7E-75 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS13860 a3beaf7e61797ffe9daf7334664f9b1e 299 Pfam PF00248 Aldo/keto reductase family 21 297 1.4E-61 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS13860 a3beaf7e61797ffe9daf7334664f9b1e 299 SUPERFAMILY SSF51430 16 298 1.7E-76 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS13860 a3beaf7e61797ffe9daf7334664f9b1e 299 PRINTS PR00069 Aldo-keto reductase signature 51 75 7.8E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS13860 a3beaf7e61797ffe9daf7334664f9b1e 299 PRINTS PR00069 Aldo-keto reductase signature 161 178 7.8E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS13860 a3beaf7e61797ffe9daf7334664f9b1e 299 PRINTS PR00069 Aldo-keto reductase signature 232 256 7.8E-6 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS27915 1f08999621594e3161ebae1e800530a1 427 Gene3D G3DSA:3.40.50.1110 200 422 1.0E-27 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS27915 1f08999621594e3161ebae1e800530a1 427 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 222 417 1.3E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS27915 1f08999621594e3161ebae1e800530a1 427 SUPERFAMILY SSF52266 216 422 1.83E-43 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS28285 f7ea0555965548dbebc7ba613c6aff0f 125 Gene3D G3DSA:1.10.10.10 9 114 4.1E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS28285 f7ea0555965548dbebc7ba613c6aff0f 125 Pfam PF01638 HxlR-like helix-turn-helix 27 113 4.3E-25 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS28285 f7ea0555965548dbebc7ba613c6aff0f 125 SUPERFAMILY SSF46785 19 119 5.68E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48105 f3435892293f9bf639d775157645e189 339 Gene3D G3DSA:3.10.310.10 155 326 1.1E-56 T 17-03-2017 SHXM_RS48105 f3435892293f9bf639d775157645e189 339 SUPERFAMILY SSF54506 3 336 1.23E-89 T 17-03-2017 SHXM_RS48105 f3435892293f9bf639d775157645e189 339 Gene3D G3DSA:3.10.310.10 4 154 6.8E-54 T 17-03-2017 SHXM_RS48105 f3435892293f9bf639d775157645e189 339 PIRSF PIRSF029792 1 339 1.1E-88 T 17-03-2017 IPR008794 Proline racemase family SHXM_RS48105 f3435892293f9bf639d775157645e189 339 Pfam PF05544 Proline racemase 8 337 9.1E-85 T 17-03-2017 IPR008794 Proline racemase family SHXM_RS03615 c7d1fa4da230953de0947c08d5255dd1 505 Gene3D G3DSA:2.130.10.130 80 476 1.0E-22 T 17-03-2017 SHXM_RS03615 c7d1fa4da230953de0947c08d5255dd1 505 Pfam PF01839 FG-GAP repeat 147 172 3.1E-5 T 17-03-2017 IPR013517 FG-GAP repeat Reactome: R-HSA-216083 SHXM_RS03615 c7d1fa4da230953de0947c08d5255dd1 505 SUPERFAMILY SSF69318 71 466 3.49E-27 T 17-03-2017 SHXM_RS06500 ecdf59631d6d4335f8fc9a64c138d44c 369 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 168 364 3.2E-40 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06500 ecdf59631d6d4335f8fc9a64c138d44c 369 SMART SM00331 141 364 2.5E-35 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS06500 ecdf59631d6d4335f8fc9a64c138d44c 369 SUPERFAMILY SSF81606 154 362 2.28E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29400 3d6607b584629b1092c4fd4dba4aff7e 132 SUPERFAMILY SSF54427 1 130 4.81E-21 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS29400 3d6607b584629b1092c4fd4dba4aff7e 132 Pfam PF12680 SnoaL-like domain 10 114 2.2E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS29400 3d6607b584629b1092c4fd4dba4aff7e 132 Gene3D G3DSA:3.10.450.50 2 131 6.9E-31 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 355 361 9.4E-27 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 385 397 9.4E-27 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 66 78 9.4E-27 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 111 123 9.4E-27 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 50 60 9.4E-27 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 PRINTS PR01001 FAD-dependent glycerol-3-phosphate dehydrogenase family signature 37 49 9.4E-27 T 17-03-2017 IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase GO:0004368|GO:0006072|GO:0009331|GO:0055114 KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 Pfam PF01266 FAD dependent oxidoreductase 38 396 4.5E-48 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 Gene3D G3DSA:3.50.50.60 35 278 2.9E-41 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 Pfam PF16901 C-terminal domain of alpha-glycerophosphate oxidase 417 532 7.9E-22 T 17-03-2017 IPR031656 Alpha-glycerophosphate oxidase, C-terminal KEGG: 00564+1.1.5.3|MetaCyc: PWY-4261|MetaCyc: PWY-6118|MetaCyc: PWY-6952|Reactome: R-HSA-535734 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 SUPERFAMILY SSF54373 267 361 7.85E-9 T 17-03-2017 SHXM_RS40720 e5a31a9fc123a1ce80e1fe1b3aff5c3b 557 SUPERFAMILY SSF51905 35 277 8.14E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18355 8340689e8a1d321cb93b016027da8023 259 Pfam PF03537 Glycoside-hydrolase family GH114 34 246 2.2E-51 T 17-03-2017 IPR004352 Glycoside-hydrolase family GH114, TIM-barrel domain SHXM_RS18355 8340689e8a1d321cb93b016027da8023 259 SUPERFAMILY SSF51445 34 230 5.26E-19 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 PIRSF PIRSF019345 4 215 5.0E-53 T 17-03-2017 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 Pfam PF04079 Segregation and condensation complex subunit ScpB 21 178 4.2E-56 T 17-03-2017 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 SUPERFAMILY SSF46785 15 91 4.63E-18 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 Gene3D G3DSA:1.10.10.10 96 169 3.4E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 Gene3D G3DSA:1.10.10.10 15 92 2.3E-27 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 SUPERFAMILY SSF46785 96 169 8.58E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS17065 f86056c1cb570119592a267c1a108461 226 TIGRFAM TIGR00281 TIGR00281: segregation and condensation protein B 18 181 4.5E-29 T 17-03-2017 IPR005234 Chromosome segregation/condensation protein ScpB GO:0051304 SHXM_RS43625 0b0f8faa5ff97805009f2455108b0032 384 SUPERFAMILY SSF48576 23 343 1.15E-43 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS43625 0b0f8faa5ff97805009f2455108b0032 384 Gene3D G3DSA:1.10.600.10 24 337 1.7E-83 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS20505 1d8fabc6497225093b4b0531b4b79976 255 Gene3D G3DSA:3.40.630.30 122 251 1.5E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS20505 1d8fabc6497225093b4b0531b4b79976 255 Pfam PF08445 FR47-like protein 188 245 2.3E-8 T 17-03-2017 IPR013653 FR47-like GO:0016747 SHXM_RS20505 1d8fabc6497225093b4b0531b4b79976 255 SUPERFAMILY SSF55729 67 250 3.42E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS23155 497e16ef21fff516907f727dab2da617 419 Pfam PF07690 Major Facilitator Superfamily 22 307 4.3E-20 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS23155 497e16ef21fff516907f727dab2da617 419 SUPERFAMILY SSF103473 15 417 2.49E-36 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23155 497e16ef21fff516907f727dab2da617 419 Gene3D G3DSA:1.20.1250.20 15 200 1.7E-18 T 17-03-2017 SHXM_RS23155 497e16ef21fff516907f727dab2da617 419 Gene3D G3DSA:1.20.1250.20 226 413 7.5E-12 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 7 29 1.1E-45 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 302 317 1.1E-45 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 335 353 1.1E-45 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 317 333 1.1E-45 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 169 184 1.1E-45 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 353 369 1.1E-45 T 17-03-2017 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 SUPERFAMILY SSF51905 5 190 1.16E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 SUPERFAMILY SSF51905 289 371 1.16E-50 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 Gene3D G3DSA:3.50.50.60 5 71 5.9E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 Gene3D G3DSA:3.50.50.60 111 195 5.9E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 Gene3D G3DSA:3.50.50.60 290 369 5.9E-49 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07660 2cb2d1687e00dd78acacad6ce30c7f62 582 Pfam PF01494 FAD binding domain 5 368 1.0E-114 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS08160 7fd24cc593fb06cda384057fd9972916 395 Pfam PF13556 PucR C-terminal helix-turn-helix domain 297 351 1.0E-16 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS08160 7fd24cc593fb06cda384057fd9972916 395 Gene3D G3DSA:1.10.10.10 298 375 9.3E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 Gene3D G3DSA:3.40.50.1820 53 329 9.1E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 Pfam PF00561 alpha/beta hydrolase fold 78 182 6.6E-25 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 SUPERFAMILY SSF53474 38 329 2.88E-63 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 PRINTS PR00412 Epoxide hydrolase signature 160 173 2.4E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 PRINTS PR00412 Epoxide hydrolase signature 146 159 2.4E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 PRINTS PR00412 Epoxide hydrolase signature 83 101 2.4E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 PRINTS PR00111 Alpha/beta hydrolase fold signature 102 117 4.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 PRINTS PR00111 Alpha/beta hydrolase fold signature 146 159 4.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS23765 88a361898a473cede0d19bebc14339dd 333 PRINTS PR00111 Alpha/beta hydrolase fold signature 160 173 4.2E-5 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS12425 a01c7a619ced56f185b08fe4823b8ff2 275 Pfam PF08501 Shikimate dehydrogenase substrate binding domain 9 95 5.4E-24 T 17-03-2017 IPR013708 Shikimate dehydrogenase substrate binding, N-terminal GO:0004764|GO:0055114 KEGG: 00400+1.1.1.25|MetaCyc: PWY-6163 SHXM_RS12425 a01c7a619ced56f185b08fe4823b8ff2 275 SUPERFAMILY SSF53223 5 108 1.27E-26 T 17-03-2017 SHXM_RS12425 a01c7a619ced56f185b08fe4823b8ff2 275 SUPERFAMILY SSF51735 109 263 1.85E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12425 a01c7a619ced56f185b08fe4823b8ff2 275 Gene3D G3DSA:3.40.192.10 3 113 5.5E-38 T 17-03-2017 SHXM_RS12425 a01c7a619ced56f185b08fe4823b8ff2 275 Gene3D G3DSA:3.40.50.720 114 273 7.0E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15085 016623d5dc69a42d2a26ccd1c57e8af3 227 Pfam PF00440 Bacterial regulatory proteins, tetR family 12 52 2.1E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS15085 016623d5dc69a42d2a26ccd1c57e8af3 227 SUPERFAMILY SSF46689 6 69 4.31E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS15085 016623d5dc69a42d2a26ccd1c57e8af3 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 10 23 6.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS15085 016623d5dc69a42d2a26ccd1c57e8af3 227 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 31 54 6.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS15085 016623d5dc69a42d2a26ccd1c57e8af3 227 Gene3D G3DSA:1.10.357.10 51 183 3.4E-24 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS15085 016623d5dc69a42d2a26ccd1c57e8af3 227 Gene3D G3DSA:1.10.10.60 7 50 2.1E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Gene3D G3DSA:3.10.50.40 224 277 7.3E-5 T 17-03-2017 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Hamap MF_00303 Trigger factor [tig]. 68 492 19.924 T 17-03-2017 IPR005215 Trigger factor GO:0015031 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 TIGRFAM TIGR00115 tig: trigger factor 79 485 1.1E-124 T 17-03-2017 IPR005215 Trigger factor GO:0015031 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Pfam PF05698 Bacterial trigger factor protein (TF) C-terminus 325 487 3.4E-40 T 17-03-2017 IPR008880 Trigger factor, C-terminal GO:0006457|GO:0015031 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 SUPERFAMILY SSF102735 70 198 1.96E-37 T 17-03-2017 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 SUPERFAMILY SSF54534 200 311 1.47E-20 T 17-03-2017 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 SUPERFAMILY SSF109998 312 501 9.52E-41 T 17-03-2017 IPR027304 Trigger factor/SurA domain SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Gene3D G3DSA:1.10.3120.10 278 461 4.4E-47 T 17-03-2017 IPR008880 Trigger factor, C-terminal GO:0006457|GO:0015031 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Pfam PF05697 Bacterial trigger factor protein (TF) 70 212 1.8E-42 T 17-03-2017 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Pfam PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase 224 282 6.1E-7 T 17-03-2017 IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain GO:0006457 SHXM_RS21710 b667380847ede07b3988bd1abc0108ea 547 Gene3D G3DSA:3.30.70.1050 70 186 3.8E-35 T 17-03-2017 IPR008881 Trigger factor, ribosome-binding, bacterial GO:0006457|GO:0015031 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 Pfam PF00356 Bacterial regulatory proteins, lacI family 3 45 2.7E-16 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 SMART SM00354 1 64 1.0E-11 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 SUPERFAMILY SSF53822 54 322 1.56E-66 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 Gene3D G3DSA:3.40.50.2300 52 158 4.2E-13 T 17-03-2017 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 Pfam PF13377 Periplasmic binding protein-like domain 160 319 2.3E-37 T 17-03-2017 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 Gene3D G3DSA:3.40.50.2300 159 321 2.7E-59 T 17-03-2017 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 Gene3D G3DSA:1.10.260.40 1 45 5.7E-20 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS00895 5b8206cc6842ae14d5f911d5df843ba4 324 SUPERFAMILY SSF47413 2 47 9.85E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 Gene3D G3DSA:1.10.3680.10 21 150 1.9E-22 T 17-03-2017 IPR029024 TerB-like SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 Gene3D G3DSA:1.10.10.10 196 282 4.5E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 SMART SM00418 200 279 4.5E-15 T 17-03-2017 IPR001845 HTH ArsR-type DNA-binding domain GO:0003700|GO:0006355 SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 SUPERFAMILY SSF46785 197 280 7.06E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 Pfam PF12840 Helix-turn-helix domain 202 259 1.1E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 Pfam PF05099 Tellurite resistance protein TerB 11 151 1.5E-28 T 17-03-2017 IPR007791 Co-chaperone DjlA, N-terminal SHXM_RS10570 2d19307e3a30c21477216a2624e600fb 297 SUPERFAMILY SSF158682 16 152 9.81E-24 T 17-03-2017 IPR029024 TerB-like SHXM_RS13310 6ff1e3b260bea0a54607bf79580c8964 392 PIRSF PIRSF004640 20 380 1.6E-144 T 17-03-2017 IPR016425 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial GO:0005506|GO:0008299|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS13310 6ff1e3b260bea0a54607bf79580c8964 392 SUPERFAMILY SSF51717 54 227 3.92E-9 T 17-03-2017 IPR011005 Dihydropteroate synthase-like GO:0044237 Reactome: R-HSA-156581|Reactome: R-HSA-1614635|Reactome: R-HSA-196741|Reactome: R-HSA-3359467|Reactome: R-HSA-3359469 SHXM_RS13310 6ff1e3b260bea0a54607bf79580c8964 392 SUPERFAMILY SSF56014 283 367 1.9E-11 T 17-03-2017 SHXM_RS13310 6ff1e3b260bea0a54607bf79580c8964 392 Pfam PF04551 GcpE protein 30 369 1.0E-132 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS13310 6ff1e3b260bea0a54607bf79580c8964 392 TIGRFAM TIGR00612 ispG_gcpE: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 26 368 7.3E-127 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS13310 6ff1e3b260bea0a54607bf79580c8964 392 Hamap MF_00159 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (ferredoxin) [ispG]. 24 375 33.446 T 17-03-2017 IPR004588 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase, bacterial-type GO:0016114|GO:0046429|GO:0055114 KEGG: 00900+1.17.7.3 SHXM_RS45325 d4ec8a5170178e782678fa1b36ccbc59 223 Gene3D G3DSA:1.10.357.10 1 207 8.6E-23 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS45325 d4ec8a5170178e782678fa1b36ccbc59 223 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 66 9.6E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS45325 d4ec8a5170178e782678fa1b36ccbc59 223 SUPERFAMILY SSF46689 9 80 1.59E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS24200 9055ca4943e6f9d7c9b34cc215cd919b 162 SUPERFAMILY SSF55486 39 159 4.39E-23 T 17-03-2017 SHXM_RS24200 9055ca4943e6f9d7c9b34cc215cd919b 162 Pfam PF06262 Zinicin-like metallopeptidase 97 157 3.6E-9 T 17-03-2017 IPR010428 Zinicin-like metallopeptidase SHXM_RS04980 4ee59e8bf8f1d5a11cddca2e8cc4d79e 208 Pfam PF08808 RES domain 14 178 1.5E-23 T 17-03-2017 IPR014914 RES domain SHXM_RS04980 4ee59e8bf8f1d5a11cddca2e8cc4d79e 208 SMART SM00953 27 173 5.7E-7 T 17-03-2017 IPR014914 RES domain SHXM_RS28735 01b476016c827f109f1e923435257a37 127 SUPERFAMILY SSF54292 18 94 3.64E-16 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS28735 01b476016c827f109f1e923435257a37 127 Gene3D G3DSA:3.10.20.30 22 87 4.5E-4 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS28735 01b476016c827f109f1e923435257a37 127 Pfam PF13510 2Fe-2S iron-sulfur cluster binding domain 16 92 3.6E-24 T 17-03-2017 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 SUPERFAMILY SSF51905 3 225 6.48E-33 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 8 199 2.5E-25 T 17-03-2017 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 Gene3D G3DSA:3.50.50.60 375 411 7.9E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 Gene3D G3DSA:3.50.50.60 3 177 7.9E-40 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 131 140 3.7E-8 T 17-03-2017 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 6 28 3.7E-8 T 17-03-2017 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 171 196 3.7E-8 T 17-03-2017 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 SUPERFAMILY SSF51905 172 409 8.81E-5 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 Gene3D G3DSA:3.50.50.60 178 226 2.8E-4 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44205 6a0b5740d7afb00def06d64072a01a20 431 Gene3D G3DSA:3.50.50.60 289 348 2.8E-4 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS30860 7c1dc65dbf1cec9ed348db4f51bce024 336 SUPERFAMILY SSF48576 22 334 4.61E-83 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS30860 7c1dc65dbf1cec9ed348db4f51bce024 336 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 212 224 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS30860 7c1dc65dbf1cec9ed348db4f51bce024 336 Pfam PF00348 Polyprenyl synthetase 42 274 1.3E-57 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS30860 7c1dc65dbf1cec9ed348db4f51bce024 336 Gene3D G3DSA:1.10.600.10 21 334 3.0E-90 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS04795 0b6ef362baa92858c47e26caf15135c6 260 SUPERFAMILY SSF51658 1 257 3.14E-55 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS04795 0b6ef362baa92858c47e26caf15135c6 260 PIRSF PIRSF006241 1 259 2.4E-56 T 17-03-2017 IPR026040 Hydroxypyruvate isomerase-like KEGG: 00630+5.3.1.22 SHXM_RS04795 0b6ef362baa92858c47e26caf15135c6 260 Gene3D G3DSA:3.20.20.150 3 257 4.1E-61 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS04795 0b6ef362baa92858c47e26caf15135c6 260 Pfam PF01261 Xylose isomerase-like TIM barrel 42 219 1.3E-20 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS19430 9d4adfd6f4fe757d0e98198fb4d1746b 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 120 306 8.1E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19430 9d4adfd6f4fe757d0e98198fb4d1746b 313 Gene3D G3DSA:1.10.3720.10 15 297 1.1E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19430 9d4adfd6f4fe757d0e98198fb4d1746b 313 SUPERFAMILY SSF161098 18 306 1.96E-45 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20255 55c41f9d473524f036230db541d92380 401 SUPERFAMILY SSF53474 256 320 3.14E-6 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20255 55c41f9d473524f036230db541d92380 401 Pfam PF06259 Alpha/beta hydrolase 162 335 1.7E-54 T 17-03-2017 IPR010427 Protein of unknown function DUF1023 SHXM_RS20255 55c41f9d473524f036230db541d92380 401 Gene3D G3DSA:3.40.50.1820 256 331 2.5E-5 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS00075 93eb5f9e75acd0294f64e87aad0199b7 97 Gene3D G3DSA:1.10.10.10 21 54 4.1E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11925 909f946e3f214cea95cd71f5bbc99906 219 Pfam PF05711 Macrocin-O-methyltransferase (TylF) 30 181 1.5E-5 T 17-03-2017 IPR008884 Macrocin-O-methyltransferase SHXM_RS11925 909f946e3f214cea95cd71f5bbc99906 219 SUPERFAMILY SSF53335 16 75 3.08E-6 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11925 909f946e3f214cea95cd71f5bbc99906 219 SUPERFAMILY SSF53335 116 190 3.08E-6 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11925 909f946e3f214cea95cd71f5bbc99906 219 Gene3D G3DSA:3.40.50.150 100 194 1.1E-5 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14575 eb0e71e35bf43790f257ae4ced122670 407 Gene3D G3DSA:3.90.1150.10 215 360 2.0E-4 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS14575 eb0e71e35bf43790f257ae4ced122670 407 Pfam PF00155 Aminotransferase class I and II 40 359 1.4E-11 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS14575 eb0e71e35bf43790f257ae4ced122670 407 SUPERFAMILY SSF53383 22 359 7.72E-36 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS14575 eb0e71e35bf43790f257ae4ced122670 407 Gene3D G3DSA:3.40.640.10 39 209 2.6E-19 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS01855 3cf961f08afc409b16f0ae07c12cd78d 282 SUPERFAMILY SSF103481 171 265 2.35E-10 T 17-03-2017 SHXM_RS01855 3cf961f08afc409b16f0ae07c12cd78d 282 SUPERFAMILY SSF103481 31 122 4.32E-7 T 17-03-2017 SHXM_RS01855 3cf961f08afc409b16f0ae07c12cd78d 282 Pfam PF00892 EamA-like transporter family 131 259 5.6E-15 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS03965 3791955eddcfe00f624a611bfdd8a553 428 Pfam PF07690 Major Facilitator Superfamily 29 361 1.7E-24 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS03965 3791955eddcfe00f624a611bfdd8a553 428 Gene3D G3DSA:1.20.1250.20 12 205 1.3E-17 T 17-03-2017 SHXM_RS03965 3791955eddcfe00f624a611bfdd8a553 428 Gene3D G3DSA:1.20.1250.20 217 409 8.3E-14 T 17-03-2017 SHXM_RS03965 3791955eddcfe00f624a611bfdd8a553 428 SUPERFAMILY SSF103473 12 408 1.1E-46 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20010 902ca4e46733e7383202ba263b7669d0 160 Pfam PF07681 DoxX 22 98 7.1E-8 T 17-03-2017 IPR032808 DoxX family SHXM_RS21480 d6fe6e980cbdd2568d321093b9cb1f6f 707 SUPERFAMILY SSF56349 334 539 1.94E-8 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS21480 d6fe6e980cbdd2568d321093b9cb1f6f 707 Gene3D G3DSA:1.10.443.10 346 538 9.8E-7 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS04680 e0f4dd61abd060950ed243f484eec483 255 PIRSF PIRSF029958 1 255 1.5E-113 T 17-03-2017 IPR008701 Necrosis inducing protein SHXM_RS04680 e0f4dd61abd060950ed243f484eec483 255 Pfam PF05630 Necrosis inducing protein (NPP1) 44 244 4.8E-63 T 17-03-2017 IPR008701 Necrosis inducing protein SHXM_RS18785 a3977becc307466532c7ab206c950400 279 Gene3D G3DSA:3.60.10.10 137 196 3.6E-7 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS18785 a3977becc307466532c7ab206c950400 279 Gene3D G3DSA:3.60.10.10 18 104 3.6E-7 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS18785 a3977becc307466532c7ab206c950400 279 SUPERFAMILY SSF56219 15 119 1.56E-25 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS18785 a3977becc307466532c7ab206c950400 279 SUPERFAMILY SSF56219 147 274 1.56E-25 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS18785 a3977becc307466532c7ab206c950400 279 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 21 243 5.9E-12 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS39910 cf8b55cd23099bda5f880e946a275c81 112 SMART SM00422 18 86 3.9E-4 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS39910 cf8b55cd23099bda5f880e946a275c81 112 Pfam PF13411 MerR HTH family regulatory protein 18 81 7.6E-9 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS39910 cf8b55cd23099bda5f880e946a275c81 112 SUPERFAMILY SSF46955 18 101 5.04E-11 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS39910 cf8b55cd23099bda5f880e946a275c81 112 Gene3D G3DSA:1.10.1660.10 18 104 3.8E-12 T 17-03-2017 SHXM_RS48735 84fb3ffafe0db6933696ddb5eaf65624 315 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 110 305 2.0E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48735 84fb3ffafe0db6933696ddb5eaf65624 315 Gene3D G3DSA:1.10.3720.10 83 312 1.4E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48735 84fb3ffafe0db6933696ddb5eaf65624 315 SUPERFAMILY SSF161098 78 302 9.29E-47 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS00680 2cf0c86c8b3c7f89f3353b51e9463415 138 Pfam PF01609 Transposase DDE domain 1 128 1.1E-15 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS10620 3ab8e0ca7e56116f2e2c68389b8f9f83 354 Gene3D G3DSA:3.60.15.10 157 277 1.3E-44 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS10620 3ab8e0ca7e56116f2e2c68389b8f9f83 354 Gene3D G3DSA:3.60.15.10 10 120 1.3E-44 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS10620 3ab8e0ca7e56116f2e2c68389b8f9f83 354 SMART SM00849 36 250 3.2E-25 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS10620 3ab8e0ca7e56116f2e2c68389b8f9f83 354 SUPERFAMILY SSF56281 17 330 9.07E-52 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS10620 3ab8e0ca7e56116f2e2c68389b8f9f83 354 Pfam PF00753 Metallo-beta-lactamase superfamily 33 250 7.1E-27 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 Pfam PF00005 ABC transporter 372 521 3.2E-18 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 SMART SM00382 381 566 2.1E-8 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 Gene3D G3DSA:3.40.50.300 355 585 3.4E-52 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 Gene3D G3DSA:1.20.1560.10 23 337 7.2E-59 T 17-03-2017 SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 SUPERFAMILY SSF90123 23 333 2.22E-55 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 SUPERFAMILY SSF52540 352 590 2.38E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS46740 982a6f10d7d05624703762511ecd123b 595 Pfam PF00664 ABC transporter transmembrane region 37 307 4.3E-33 T 17-03-2017 IPR011527 ABC transporter type 1, transmembrane domain GO:0005524|GO:0006810|GO:0016021|GO:0042626|GO:0055085 SHXM_RS50135 f5f1991b3c162dd8ea45240c485f9dd4 722 SUPERFAMILY SSF52540 248 312 3.3E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50135 f5f1991b3c162dd8ea45240c485f9dd4 722 SUPERFAMILY SSF52540 38 75 3.3E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00905 54d02801e9d814ec810a3f521411ad48 103 Gene3D G3DSA:3.40.50.1820 22 81 2.6E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS00905 54d02801e9d814ec810a3f521411ad48 103 SUPERFAMILY SSF53474 20 89 4.85E-8 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32215 f666eaef0cd7a0f83d2e7296ad14ebc0 98 SUPERFAMILY SSF53244 1 90 2.38E-15 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS32215 f666eaef0cd7a0f83d2e7296ad14ebc0 98 Gene3D G3DSA:3.90.190.20 1 92 2.7E-20 T 17-03-2017 IPR004101 Mur ligase, C-terminal GO:0005524|GO:0009058|GO:0016874 Reactome: R-HSA-196757 SHXM_RS17885 ef28d59d1dfb8dd66998a03731b9093c 383 TIGRFAM TIGR00534 OpcA: glucose-6-phosphate dehydrogenase assembly protein OpcA 1 297 9.6E-92 T 17-03-2017 IPR004555 Glucose-6-phosphate dehydrogenase assembly protein OpcA SHXM_RS17885 ef28d59d1dfb8dd66998a03731b9093c 383 Pfam PF10128 Glucose-6-phosphate dehydrogenase subunit 51 298 7.4E-84 T 17-03-2017 IPR004555 Glucose-6-phosphate dehydrogenase assembly protein OpcA SHXM_RS31980 e8251e5cb331446d7891679566e311f8 488 Gene3D G3DSA:2.60.40.1180 383 483 8.0E-12 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS31980 e8251e5cb331446d7891679566e311f8 488 SUPERFAMILY SSF51445 41 390 9.4E-37 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS31980 e8251e5cb331446d7891679566e311f8 488 Gene3D G3DSA:3.20.20.80 41 382 9.8E-89 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS31980 e8251e5cb331446d7891679566e311f8 488 Pfam PF14587 O-Glycosyl hydrolase family 30 29 266 7.2E-11 T 17-03-2017 SHXM_RS31720 033a97c78c8c8d56a84ca4113d1f8aa2 205 Pfam PF01613 Flavin reductase like domain 51 199 5.5E-37 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS31720 033a97c78c8c8d56a84ca4113d1f8aa2 205 SMART SM00903 50 200 4.9E-58 T 17-03-2017 IPR002563 Flavin reductase like domain GO:0010181 SHXM_RS31720 033a97c78c8c8d56a84ca4113d1f8aa2 205 SUPERFAMILY SSF50475 41 199 9.32E-48 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS31720 033a97c78c8c8d56a84ca4113d1f8aa2 205 Gene3D G3DSA:2.30.110.10 38 199 3.1E-55 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS20300 26b0077963c1d5807368adcd01bfeb27 394 Pfam PF13556 PucR C-terminal helix-turn-helix domain 326 383 8.7E-20 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS34885 5db5f3a61f8734ba139d550a118b52f1 184 Gene3D G3DSA:3.40.50.360 3 173 1.1E-46 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS34885 5db5f3a61f8734ba139d550a118b52f1 184 SUPERFAMILY SSF52218 3 172 2.3E-47 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS34885 5db5f3a61f8734ba139d550a118b52f1 184 Pfam PF02525 Flavodoxin-like fold 3 170 1.3E-42 T 17-03-2017 IPR003680 Flavodoxin-like fold SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 Gene3D G3DSA:2.30.40.10 541 580 3.2E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 Pfam PF07969 Amidohydrolase family 100 594 1.3E-80 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 SUPERFAMILY SSF51338 45 111 2.14E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 SUPERFAMILY SSF51338 554 597 2.14E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 Gene3D G3DSA:3.20.20.140 253 540 1.5E-26 T 17-03-2017 SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 Gene3D G3DSA:2.30.40.10 49 140 5.4E-16 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 SUPERFAMILY SSF51556 251 554 1.0E-27 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS13875 e24bf62ba03a929c3d9e370a5ad09542 630 SUPERFAMILY SSF51556 111 175 1.0E-27 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS15475 3dd3cc5d96d320f96a25d441d0537e69 444 Gene3D G3DSA:3.20.20.140 83 378 5.6E-101 T 17-03-2017 SHXM_RS15475 3dd3cc5d96d320f96a25d441d0537e69 444 Pfam PF07969 Amidohydrolase family 115 419 1.8E-32 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS15475 3dd3cc5d96d320f96a25d441d0537e69 444 Gene3D G3DSA:2.30.40.10 19 82 2.7E-12 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15475 3dd3cc5d96d320f96a25d441d0537e69 444 SUPERFAMILY SSF51338 381 423 1.42E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15475 3dd3cc5d96d320f96a25d441d0537e69 444 SUPERFAMILY SSF51338 11 70 1.42E-13 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS15475 3dd3cc5d96d320f96a25d441d0537e69 444 SUPERFAMILY SSF51556 70 390 7.13E-90 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS01905 9ebcab091c7667acac9dd1b7b8ff38e2 363 Pfam PF00296 Luciferase-like monooxygenase 7 301 3.5E-62 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01905 9ebcab091c7667acac9dd1b7b8ff38e2 363 Gene3D G3DSA:3.20.20.30 1 339 7.0E-79 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01905 9ebcab091c7667acac9dd1b7b8ff38e2 363 SUPERFAMILY SSF51679 20 330 1.57E-70 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS04410 59ae7f3336dbbef77a41aa2af93c8f1c 482 Gene3D G3DSA:3.40.605.10 8 268 9.7E-87 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS04410 59ae7f3336dbbef77a41aa2af93c8f1c 482 SUPERFAMILY SSF53720 4 480 2.23E-152 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS04410 59ae7f3336dbbef77a41aa2af93c8f1c 482 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 282 293 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS04410 59ae7f3336dbbef77a41aa2af93c8f1c 482 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 254 261 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS04410 59ae7f3336dbbef77a41aa2af93c8f1c 482 Gene3D G3DSA:3.40.309.10 269 458 2.5E-59 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS04410 59ae7f3336dbbef77a41aa2af93c8f1c 482 Pfam PF00171 Aldehyde dehydrogenase family 17 478 4.3E-156 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS39700 fb735d3066bd63811f74b94fc0b29701 138 SUPERFAMILY SSF50118 86 134 6.02E-7 T 17-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor SHXM_RS39700 fb735d3066bd63811f74b94fc0b29701 138 SUPERFAMILY SSF50118 2 43 6.02E-7 T 17-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor SHXM_RS26590 c5b54c8d956103173ec14e29a10ace41 115 Gene3D G3DSA:3.40.50.2300 1 89 9.6E-14 T 17-03-2017 SHXM_RS26590 c5b54c8d956103173ec14e29a10ace41 115 SUPERFAMILY SSF52172 1 89 1.99E-14 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS26590 c5b54c8d956103173ec14e29a10ace41 115 Pfam PF00072 Response regulator receiver domain 4 89 7.5E-8 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37730 eb058cf431b35c54f4ac55c0bef97d99 230 Pfam PF01391 Collagen triple helix repeat (20 copies) 26 66 1.4E-7 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS03695 8f448e472e20d78ce4f6ffe342afaea0 529 Pfam PF00474 Sodium:solute symporter family 38 453 7.5E-42 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS22630 20e51a4c278b797532a77523488a39b7 302 Pfam PF09851 Short C-terminal domain 270 296 1.9E-6 T 17-03-2017 IPR018649 SHOCT domain SHXM_RS22630 20e51a4c278b797532a77523488a39b7 302 Pfam PF14472 Domain of unknown function (DUF4429) 139 225 3.9E-20 T 17-03-2017 IPR027860 Domain of unknown function DUF4429 SHXM_RS22630 20e51a4c278b797532a77523488a39b7 302 Pfam PF14472 Domain of unknown function (DUF4429) 11 105 6.5E-21 T 17-03-2017 IPR027860 Domain of unknown function DUF4429 SHXM_RS29965 69c038fa6e2bb578a7221922e4c77d3b 366 SUPERFAMILY SSF54001 250 358 2.16E-32 T 17-03-2017 SHXM_RS29965 69c038fa6e2bb578a7221922e4c77d3b 366 Gene3D G3DSA:3.90.1720.10 253 352 3.8E-34 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS29965 69c038fa6e2bb578a7221922e4c77d3b 366 Pfam PF00877 NlpC/P60 family 264 348 8.8E-20 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS35655 154caba606b263fc3e84b98c466380df 214 SUPERFAMILY SSF53597 8 208 1.31E-20 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS35655 154caba606b263fc3e84b98c466380df 214 Gene3D G3DSA:3.40.430.10 7 211 1.3E-40 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS35655 154caba606b263fc3e84b98c466380df 214 Pfam PF01872 RibD C-terminal domain 8 189 7.9E-14 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS38055 1cdb21109c649617a1a5ec64266184dc 112 SUPERFAMILY SSF51735 1 104 3.1E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38055 1cdb21109c649617a1a5ec64266184dc 112 Gene3D G3DSA:3.40.50.720 1 59 3.2E-5 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48980 14ffcc6637878ecaae656a2b5e101ffc 113 Gene3D G3DSA:1.10.10.10 12 97 9.5E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS48980 14ffcc6637878ecaae656a2b5e101ffc 113 Pfam PF03551 Transcriptional regulator PadR-like family 15 87 2.7E-19 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS48980 14ffcc6637878ecaae656a2b5e101ffc 113 SUPERFAMILY SSF46785 12 99 4.89E-24 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS21355 ba115768ed805bb1bf43878ef0338001 234 Pfam PF01965 DJ-1/PfpI family 29 228 2.8E-15 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS21355 ba115768ed805bb1bf43878ef0338001 234 Gene3D G3DSA:3.40.50.880 1 231 4.5E-80 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS21355 ba115768ed805bb1bf43878ef0338001 234 SUPERFAMILY SSF52317 2 230 3.62E-64 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS12755 1cf7ac146b6b95fbec01baa828a44c43 154 Pfam PF01638 HxlR-like helix-turn-helix 21 105 1.8E-21 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS12755 1cf7ac146b6b95fbec01baa828a44c43 154 SUPERFAMILY SSF46785 7 144 1.63E-41 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS12755 1cf7ac146b6b95fbec01baa828a44c43 154 Gene3D G3DSA:1.10.10.10 2 106 7.1E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 SUPERFAMILY SSF53167 17 261 1.44E-38 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 Gene3D G3DSA:1.25.40.10 526 607 5.5E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 Gene3D G3DSA:1.25.40.10 460 488 5.5E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 SUPERFAMILY SSF48452 460 489 4.82E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 SUPERFAMILY SSF48452 521 602 4.82E-10 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 Pfam PF13374 Tetratricopeptide repeat 532 571 0.0015 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 Pfam PF01048 Phosphorylase superfamily 18 258 5.0E-28 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS04815 639df41b59c4b009592808954b80dfed 712 Gene3D G3DSA:3.40.50.1580 17 260 2.4E-43 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS15080 6acb6c73bf10f68503f53450eae46dbe 240 Gene3D G3DSA:1.10.630.10 36 239 1.2E-32 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS15080 6acb6c73bf10f68503f53450eae46dbe 240 SUPERFAMILY SSF48264 33 231 7.8E-23 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS37500 a11383802b01678eeed434570d7c42b2 324 PIRSF PIRSF035042 1 312 1.3E-68 T 17-03-2017 IPR010350 Thioredoxin-like ferredoxin, bacteria SHXM_RS37500 a11383802b01678eeed434570d7c42b2 324 Gene3D G3DSA:3.40.30.10 139 228 3.0E-12 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS37500 a11383802b01678eeed434570d7c42b2 324 Pfam PF06999 Sucrase/ferredoxin-like 17 223 2.0E-20 T 17-03-2017 IPR009737 Thioredoxin-like ferredoxin SHXM_RS37500 a11383802b01678eeed434570d7c42b2 324 SUPERFAMILY SSF52833 137 228 5.26E-13 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS44800 637227372ed320457cfb9969c2760fbe 123 Pfam PF13411 MerR HTH family regulatory protein 1 67 6.4E-16 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44800 637227372ed320457cfb9969c2760fbe 123 SUPERFAMILY SSF46955 1 114 1.1E-23 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS44800 637227372ed320457cfb9969c2760fbe 123 SMART SM00422 1 69 1.2E-15 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS44800 637227372ed320457cfb9969c2760fbe 123 Gene3D G3DSA:1.10.1660.10 1 116 5.1E-27 T 17-03-2017 SHXM_RS50215 a34bd7e0aaf01e7122aca75be9b0a256 185 TIGRFAM TIGR03567 FMN_reduc_SsuE: FMN reductase 4 171 1.6E-66 T 17-03-2017 IPR020048 NADPH-dependent FMN reductase, SsuE GO:0008752|GO:0046306|GO:0055114 KEGG: 00740+1.5.1.38|MetaCyc: PWY-7723 SHXM_RS50215 a34bd7e0aaf01e7122aca75be9b0a256 185 Gene3D G3DSA:3.40.50.360 2 174 5.1E-34 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS50215 a34bd7e0aaf01e7122aca75be9b0a256 185 SUPERFAMILY SSF52218 4 170 2.33E-32 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS50215 a34bd7e0aaf01e7122aca75be9b0a256 185 Pfam PF03358 NADPH-dependent FMN reductase 4 144 5.4E-32 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS43060 ccd8609eac7374d90893d9f2e5c12318 225 Pfam PF13578 Methyltransferase domain 81 183 8.2E-19 T 17-03-2017 SHXM_RS43060 ccd8609eac7374d90893d9f2e5c12318 225 Gene3D G3DSA:3.40.50.150 36 223 5.9E-38 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS43060 ccd8609eac7374d90893d9f2e5c12318 225 SUPERFAMILY SSF53335 40 200 4.14E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS39660 cfe489e53e25f63c9e908bb0c7d3c0de 332 Gene3D G3DSA:3.30.420.40 32 164 3.9E-20 T 17-03-2017 SHXM_RS39660 cfe489e53e25f63c9e908bb0c7d3c0de 332 Gene3D G3DSA:3.30.420.40 165 300 9.0E-37 T 17-03-2017 SHXM_RS39660 cfe489e53e25f63c9e908bb0c7d3c0de 332 Pfam PF00480 ROK family 33 323 1.2E-37 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS39660 cfe489e53e25f63c9e908bb0c7d3c0de 332 SUPERFAMILY SSF53067 32 323 9.72E-40 T 17-03-2017 SHXM_RS38425 8b8f5a7c56bd0082796923cfbf03aaba 155 Pfam PF01638 HxlR-like helix-turn-helix 20 106 1.7E-16 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS38425 8b8f5a7c56bd0082796923cfbf03aaba 155 Gene3D G3DSA:1.10.10.10 14 112 2.8E-23 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38425 8b8f5a7c56bd0082796923cfbf03aaba 155 SUPERFAMILY SSF46785 15 144 3.0E-30 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08400 e2cbe89724f7467a1e7a2c4b77de74a6 242 SUPERFAMILY SSF52317 20 214 3.16E-19 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS08400 e2cbe89724f7467a1e7a2c4b77de74a6 242 Gene3D G3DSA:3.40.50.880 22 213 1.4E-19 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS08400 e2cbe89724f7467a1e7a2c4b77de74a6 242 Pfam PF07685 CobB/CobQ-like glutamine amidotransferase domain 9 202 2.4E-35 T 17-03-2017 IPR011698 CobB/CobQ-like glutamine amidotransferase GO:0003824|GO:0009236 SHXM_RS06560 44b282eea7fcca2be8f1eded88e6557b 307 Hamap MF_01876 Pseudouridine-5'-phosphate glycosidase [psuG]. 12 305 43.638 T 17-03-2017 IPR007342 Pseudouridine-5'-phosphate glycosidase GO:0016798 KEGG: 00240+4.2.1.70|MetaCyc: PWY-6019 SHXM_RS06560 44b282eea7fcca2be8f1eded88e6557b 307 SUPERFAMILY SSF110581 6 303 1.57E-115 T 17-03-2017 SHXM_RS06560 44b282eea7fcca2be8f1eded88e6557b 307 Pfam PF04227 Indigoidine synthase A like protein 13 301 2.9E-131 T 17-03-2017 IPR007342 Pseudouridine-5'-phosphate glycosidase GO:0016798 KEGG: 00240+4.2.1.70|MetaCyc: PWY-6019 SHXM_RS14030 dc29e0fedc58cbef1430db3307b3664f 347 Gene3D G3DSA:3.40.50.1820 227 346 3.9E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14030 dc29e0fedc58cbef1430db3307b3664f 347 Gene3D G3DSA:3.40.50.1820 60 195 3.9E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS14030 dc29e0fedc58cbef1430db3307b3664f 347 Pfam PF12146 Serine aminopeptidase, S33 106 327 3.5E-13 T 17-03-2017 IPR022742 Serine aminopeptidase, S33 SHXM_RS14030 dc29e0fedc58cbef1430db3307b3664f 347 SUPERFAMILY SSF53474 61 346 3.48E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS32335 79438669eddbe2b28489565c62ca5a40 260 Pfam PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase 28 237 4.3E-44 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS32335 79438669eddbe2b28489565c62ca5a40 260 Gene3D G3DSA:3.40.830.10 5 260 1.8E-88 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS32335 79438669eddbe2b28489565c62ca5a40 260 SUPERFAMILY SSF53213 7 260 1.44E-84 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS32335 79438669eddbe2b28489565c62ca5a40 260 PIRSF PIRSF006157 3 260 2.2E-88 T 17-03-2017 IPR014436 Extradiol aromatic ring-opening dioxygenase, DODA type GO:0008270|GO:0016701|GO:0055114 SHXM_RS42690 fcf9c0fde8ef85e10190abe0e9cd0da1 544 Pfam PF13751 Transposase DDE domain 403 527 3.1E-26 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS42690 fcf9c0fde8ef85e10190abe0e9cd0da1 544 Pfam PF05598 Transposase domain (DUF772) 53 120 7.0E-17 T 17-03-2017 IPR008490 Transposase InsH, N-terminal SHXM_RS10275 c96dd3c1dd597c81f335812d997b6cc9 417 SUPERFAMILY SSF53756 30 359 1.46E-6 T 17-03-2017 SHXM_RS03350 4413d433f2a686e7f8bd2ae3af730075 291 Pfam PF02668 Taurine catabolism dioxygenase TauD, TfdA family 24 281 2.6E-62 T 17-03-2017 IPR003819 TauD/TfdA-like domain GO:0016491|GO:0055114 Reactome: R-HSA-71262 SHXM_RS03350 4413d433f2a686e7f8bd2ae3af730075 291 SUPERFAMILY SSF51197 23 291 4.26E-88 T 17-03-2017 SHXM_RS03350 4413d433f2a686e7f8bd2ae3af730075 291 Gene3D G3DSA:3.60.130.10 20 291 4.7E-90 T 17-03-2017 SHXM_RS05995 7467fe7ca366b2e4db811f3b8dd276b1 101 SUPERFAMILY SSF57716 2 101 8.55E-34 T 17-03-2017 SHXM_RS05995 7467fe7ca366b2e4db811f3b8dd276b1 101 Gene3D G3DSA:4.10.830.10 41 101 6.4E-28 T 17-03-2017 SHXM_RS05995 7467fe7ca366b2e4db811f3b8dd276b1 101 Hamap MF_00537 30S ribosomal protein S14 [rpsN]. 1 101 26.77 T 17-03-2017 IPR023036 Ribosomal protein S14, bacterial/plastid SHXM_RS05995 7467fe7ca366b2e4db811f3b8dd276b1 101 Pfam PF00253 Ribosomal protein S14p/S29e 48 100 2.0E-23 T 17-03-2017 IPR001209 Ribosomal protein S14 GO:0003735|GO:0005622|GO:0005840|GO:0006412 SHXM_RS26575 24153c2d4f25b34a8d1b12a87aa81bd4 153 Pfam PF13490 Putative zinc-finger 33 61 4.8E-8 T 17-03-2017 IPR027383 Putative zinc-finger SHXM_RS37635 be4560acae7147ec38b3176bc022e4dd 261 Pfam PF12502 Protein of unknown function (DUF3710) 55 228 2.1E-60 T 17-03-2017 IPR022183 Protein of unknown function DUF3710 SHXM_RS39125 6a7ac68825fa87665c71ddd895d81b2c 259 TIGRFAM TIGR00633 xth: exodeoxyribonuclease III (xth) 1 257 2.2E-77 T 17-03-2017 IPR004808 AP endonuclease 1 GO:0004518|GO:0006281 SHXM_RS39125 6a7ac68825fa87665c71ddd895d81b2c 259 TIGRFAM TIGR00195 exoDNase_III: exodeoxyribonuclease III 1 256 7.2E-58 T 17-03-2017 SHXM_RS39125 6a7ac68825fa87665c71ddd895d81b2c 259 SUPERFAMILY SSF56219 1 258 6.28E-67 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS39125 6a7ac68825fa87665c71ddd895d81b2c 259 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 4 250 2.2E-20 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS39125 6a7ac68825fa87665c71ddd895d81b2c 259 Gene3D G3DSA:3.60.10.10 1 258 1.1E-75 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS04640 0b379a02920ca0d5e527d267270a7670 253 Gene3D G3DSA:3.50.30.40 37 194 4.3E-48 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS04640 0b379a02920ca0d5e527d267270a7670 253 SUPERFAMILY SSF89562 37 197 2.35E-47 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS04640 0b379a02920ca0d5e527d267270a7670 253 Pfam PF03737 Demethylmenaquinone methyltransferase 40 186 3.4E-40 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS02555 e95e0385d4c810f3f070b2016879d9bd 268 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 3 219 9.6E-13 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS50930 ee62be027b14ee580c2385f1dc339794 247 SUPERFAMILY SSF52540 20 245 3.34E-13 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50930 ee62be027b14ee580c2385f1dc339794 247 Gene3D G3DSA:3.40.50.300 25 138 1.7E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS50930 ee62be027b14ee580c2385f1dc339794 247 Pfam PF13401 AAA domain 36 155 1.2E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 SUPERFAMILY SSF51905 4 198 6.85E-26 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 147 165 1.6E-5 T 17-03-2017 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 1.6E-5 T 17-03-2017 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 Gene3D G3DSA:3.50.50.60 5 199 1.9E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 6 28 3.1E-5 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 143 167 3.1E-5 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 Pfam PF00890 FAD binding domain 6 52 8.5E-9 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS39765 164923db80251c035c0b2ed91a266568 201 Pfam PF00890 FAD binding domain 88 195 2.0E-6 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS18835 8417bbca2f9d187257976512ee76ad7a 341 Pfam PF00877 NlpC/P60 family 242 336 3.0E-24 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS18835 8417bbca2f9d187257976512ee76ad7a 341 SUPERFAMILY SSF54001 225 332 2.75E-38 T 17-03-2017 SHXM_RS18835 8417bbca2f9d187257976512ee76ad7a 341 Gene3D G3DSA:3.90.1720.10 224 331 1.9E-40 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS31455 c1470ed1fca9a4ee99f31f621e969897 230 Gene3D G3DSA:3.40.630.30 2 143 8.1E-32 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS31455 c1470ed1fca9a4ee99f31f621e969897 230 TIGRFAM TIGR01575 rimI: ribosomal-protein-alanine acetyltransferase 5 141 4.5E-32 T 17-03-2017 IPR006464 Ribosomal-protein-alanine acetyltransferase GO:0006474|GO:0016407 SHXM_RS31455 c1470ed1fca9a4ee99f31f621e969897 230 SUPERFAMILY SSF55729 5 144 3.14E-28 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS31455 c1470ed1fca9a4ee99f31f621e969897 230 Pfam PF00583 Acetyltransferase (GNAT) family 47 122 6.5E-15 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS23805 0bf8fc36f7d591bdb1a62bdd22291cb5 221 SUPERFAMILY SSF46689 9 90 4.44E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS23805 0bf8fc36f7d591bdb1a62bdd22291cb5 221 Pfam PF00440 Bacterial regulatory proteins, tetR family 21 63 8.8E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS23805 0bf8fc36f7d591bdb1a62bdd22291cb5 221 Gene3D G3DSA:1.10.10.60 10 62 1.2E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS23805 0bf8fc36f7d591bdb1a62bdd22291cb5 221 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 42 65 6.6E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS23805 0bf8fc36f7d591bdb1a62bdd22291cb5 221 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 21 34 6.6E-6 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS23805 0bf8fc36f7d591bdb1a62bdd22291cb5 221 Gene3D G3DSA:1.10.357.10 63 213 4.3E-15 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS40845 c44bd08e836b2dfa00619abb664eaf5c 561 SUPERFAMILY SSF53756 146 347 1.76E-6 T 17-03-2017 SHXM_RS24035 1d1c6ec964f2ce63f14d9cdfab40e864 667 Gene3D G3DSA:3.90.550.10 11 230 1.6E-35 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24035 1d1c6ec964f2ce63f14d9cdfab40e864 667 SUPERFAMILY SSF53448 6 245 2.08E-40 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24035 1d1c6ec964f2ce63f14d9cdfab40e864 667 Pfam PF00535 Glycosyl transferase family 2 14 146 1.8E-27 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS02300 7050e33ee11b41c5d069b40aee51deb2 62 Gene3D G3DSA:1.10.357.10 2 62 6.4E-8 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS02300 7050e33ee11b41c5d069b40aee51deb2 62 SUPERFAMILY SSF48498 4 60 2.37E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 Gene3D G3DSA:3.30.9.10 244 333 7.3E-18 T 17-03-2017 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 Gene3D G3DSA:3.30.9.10 105 164 7.3E-18 T 17-03-2017 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 SUPERFAMILY SSF54373 252 330 8.63E-8 T 17-03-2017 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 SUPERFAMILY SSF51905 334 394 8.91E-55 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 SUPERFAMILY SSF51905 23 244 8.91E-55 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 TIGRFAM TIGR01373 soxB: sarcosine oxidase, beta subunit family 13 398 1.0E-189 T 17-03-2017 IPR006278 Sarcosine oxidase subunit beta GO:0008115|GO:0046653|GO:0055114 KEGG: 00260+1.5.3.1|MetaCyc: PWY-3661|MetaCyc: PWY-4722 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 Pfam PF01266 FAD dependent oxidoreductase 24 370 1.2E-56 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 Gene3D G3DSA:3.50.50.60 16 101 1.0E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 Gene3D G3DSA:3.50.50.60 165 243 1.0E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS41775 9405d502e3f0235ae89970a52e3f7e4b 406 Gene3D G3DSA:3.50.50.60 334 392 1.0E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS44805 308729dd858047f55046956ba73deee7 644 SUPERFAMILY SSF53649 518 554 8.37E-9 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS44805 308729dd858047f55046956ba73deee7 644 SUPERFAMILY SSF53649 354 490 8.37E-9 T 17-03-2017 IPR017850 Alkaline-phosphatase-like, core domain GO:0003824|GO:0008152 SHXM_RS44805 308729dd858047f55046956ba73deee7 644 Gene3D G3DSA:3.40.720.10 385 555 8.3E-6 T 17-03-2017 IPR017849 Alkaline phosphatase-like, alpha/beta/alpha GO:0003824|GO:0008152 SHXM_RS13685 528780b0da3d4e424f66eacd0a4717d6 285 SMART SM00530 30 85 2.3E-5 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS13685 528780b0da3d4e424f66eacd0a4717d6 285 Pfam PF13560 Helix-turn-helix domain 27 85 4.0E-11 T 17-03-2017 SHXM_RS13685 528780b0da3d4e424f66eacd0a4717d6 285 SUPERFAMILY SSF47413 25 79 1.27E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13685 528780b0da3d4e424f66eacd0a4717d6 285 Gene3D G3DSA:1.10.260.40 26 79 2.9E-8 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS14875 f5d95ef2396ab017bf657f36954b9d61 550 PRINTS PR01217 Proline rich extensin signature 222 243 1.8E-9 T 17-03-2017 SHXM_RS14875 f5d95ef2396ab017bf657f36954b9d61 550 PRINTS PR01217 Proline rich extensin signature 183 199 1.8E-9 T 17-03-2017 SHXM_RS14875 f5d95ef2396ab017bf657f36954b9d61 550 PRINTS PR01217 Proline rich extensin signature 207 219 1.8E-9 T 17-03-2017 SHXM_RS14875 f5d95ef2396ab017bf657f36954b9d61 550 PRINTS PR01217 Proline rich extensin signature 254 270 1.8E-9 T 17-03-2017 SHXM_RS14875 f5d95ef2396ab017bf657f36954b9d61 550 PRINTS PR01217 Proline rich extensin signature 168 180 1.8E-9 T 17-03-2017 SHXM_RS28510 de71b294e3879fa007af3c1050f5eaba 165 Pfam PF07179 SseB protein N-terminal domain 51 153 4.4E-8 T 17-03-2017 IPR009839 SseB protein N-terminal domain SHXM_RS23645 14d72d784b7ec9ed7b14e9c281d6d1d5 712 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 550 558 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS23645 14d72d784b7ec9ed7b14e9c281d6d1d5 712 Pfam PF01799 [2Fe-2S] binding domain 584 656 1.8E-25 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS23645 14d72d784b7ec9ed7b14e9c281d6d1d5 712 Gene3D G3DSA:1.10.150.120 586 671 2.8E-31 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS23645 14d72d784b7ec9ed7b14e9c281d6d1d5 712 SUPERFAMILY SSF47741 595 662 7.98E-28 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS23645 14d72d784b7ec9ed7b14e9c281d6d1d5 712 SUPERFAMILY SSF54292 512 588 5.11E-18 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS23645 14d72d784b7ec9ed7b14e9c281d6d1d5 712 Gene3D G3DSA:3.10.20.30 513 585 2.6E-25 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS39490 eda2aa7a2c6f9f30f7560a3933223044 75 Pfam PF01526 Tn3 transposase DDE domain 17 53 2.1E-6 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 Gene3D G3DSA:3.30.1340.10 1 88 1.4E-24 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 ProSitePatterns PS00369 PTS HPR domain histidine phosphorylation site signature. 13 20 - T 17-03-2017 IPR001020 Phosphotransferase system, HPr histidine phosphorylation site SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 SUPERFAMILY SSF55594 1 88 5.63E-20 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 Pfam PF00381 PTS HPr component phosphorylation site 3 83 3.3E-22 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 PRINTS PR00107 Phosphocarrier protein signature 54 71 2.1E-10 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 PRINTS PR00107 Phosphocarrier protein signature 13 29 2.1E-10 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 PRINTS PR00107 Phosphocarrier protein signature 39 54 2.1E-10 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS37535 90e48150caf09d5bd774aab23e97e962 93 TIGRFAM TIGR01003 PTS_HPr_family: phosphocarrier, HPr family 1 82 1.6E-24 T 17-03-2017 IPR000032 Phosphocarrier protein HPr-like SHXM_RS26535 7edc2dc71b5928b115797073be082434 156 SUPERFAMILY SSF55874 46 140 2.3E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26535 7edc2dc71b5928b115797073be082434 156 Pfam PF13581 Histidine kinase-like ATPase domain 25 148 6.5E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS20410 4b4f01dd16175b8ce7baec438ac4afcf 267 Pfam PF07264 Etoposide-induced protein 2.4 (EI24) 10 229 1.1E-29 T 17-03-2017 SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 Gene3D G3DSA:3.30.70.360 187 289 2.9E-22 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 PIRSF PIRSF037238 4 380 2.9E-109 T 17-03-2017 IPR017150 Peptidase M20, glutamate carboxypeptidase SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 SUPERFAMILY SSF55031 186 289 3.14E-19 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 Pfam PF07687 Peptidase dimerisation domain 183 278 2.0E-17 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 Pfam PF01546 Peptidase family M20/M25/M40 84 372 1.7E-21 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 SUPERFAMILY SSF53187 305 380 4.1E-42 T 17-03-2017 SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 SUPERFAMILY SSF53187 5 195 4.1E-42 T 17-03-2017 SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 Gene3D G3DSA:3.40.630.10 294 380 3.2E-40 T 17-03-2017 SHXM_RS44845 efe8c3f397758806e0262010c2597b20 384 Gene3D G3DSA:3.40.630.10 8 186 3.2E-40 T 17-03-2017 SHXM_RS02460 a521f7056cff490542338b0fed779589 98 Gene3D G3DSA:1.10.10.10 4 69 5.3E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02460 a521f7056cff490542338b0fed779589 98 Pfam PF00392 Bacterial regulatory proteins, gntR family 6 66 8.7E-10 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS02460 a521f7056cff490542338b0fed779589 98 SUPERFAMILY SSF46785 4 69 2.44E-11 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02460 a521f7056cff490542338b0fed779589 98 SMART SM00345 9 66 6.4E-9 T 17-03-2017 IPR000524 Transcription regulator HTH, GntR GO:0003700|GO:0006355 SHXM_RS01875 3de0e25e1a020f0c607cb974b01b04f7 69 Gene3D G3DSA:1.10.3860.10 2 69 1.4E-13 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS01875 3de0e25e1a020f0c607cb974b01b04f7 69 PRINTS PR00173 Glutamate-aspartate symporter signature 11 31 3.8E-8 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS01875 3de0e25e1a020f0c607cb974b01b04f7 69 PRINTS PR00173 Glutamate-aspartate symporter signature 41 66 3.8E-8 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS01875 3de0e25e1a020f0c607cb974b01b04f7 69 SUPERFAMILY SSF118215 3 69 1.27E-14 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS01875 3de0e25e1a020f0c607cb974b01b04f7 69 Pfam PF00375 Sodium:dicarboxylate symporter family 2 69 4.0E-14 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS33530 6528ef5b048ae3eb56363d50d212b118 464 Pfam PF01594 Domain of unknown function DUF20 101 421 9.5E-60 T 17-03-2017 IPR002549 Transmembrane protein TqsA-like SHXM_RS38175 5c211d4684e30758e7d8b354e39af564 305 SUPERFAMILY SSF161098 51 293 1.44E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38175 5c211d4684e30758e7d8b354e39af564 305 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 301 5.9E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38175 5c211d4684e30758e7d8b354e39af564 305 Gene3D G3DSA:1.10.3720.10 57 301 3.5E-60 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38480 f4d261e1f559e15d4daeb705bd50602e 294 Pfam PF01872 RibD C-terminal domain 73 268 5.2E-32 T 17-03-2017 IPR002734 Bacterial bifunctional deaminase-reductase, C-terminal GO:0008703|GO:0009231|GO:0055114 SHXM_RS38480 f4d261e1f559e15d4daeb705bd50602e 294 SUPERFAMILY SSF53597 73 291 1.61E-38 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS38480 f4d261e1f559e15d4daeb705bd50602e 294 Gene3D G3DSA:3.40.430.10 70 291 5.3E-60 T 17-03-2017 IPR024072 Dihydrofolate reductase-like domain Reactome: R-HSA-196757 SHXM_RS03970 e7e7b18b022d09165346622a29f8bfd7 174 Pfam PF11066 Protein of unknown function (DUF2867) 26 150 8.6E-5 T 17-03-2017 IPR021295 Protein of unknown function DUF2867 SHXM_RS34650 bcc5c6b1ee9803c2de9ae68e121c1b50 536 TIGRFAM TIGR00831 a_cpa1: Na+/H+ antiporter 7 526 5.3E-101 T 17-03-2017 IPR004705 Cation/H+ exchanger, CPA1 family, bacteria GO:0006812|GO:0015299|GO:0016021 SHXM_RS34650 bcc5c6b1ee9803c2de9ae68e121c1b50 536 Pfam PF00999 Sodium/hydrogen exchanger family 9 402 6.0E-61 T 17-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SHXM_RS50205 2cb95ed12d9c8d8d946562db0d98b037 328 Gene3D G3DSA:1.10.3720.10 55 134 8.7E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50205 2cb95ed12d9c8d8d946562db0d98b037 328 Gene3D G3DSA:1.10.3720.10 175 319 8.7E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50205 2cb95ed12d9c8d8d946562db0d98b037 328 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 79 315 2.0E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50205 2cb95ed12d9c8d8d946562db0d98b037 328 SUPERFAMILY SSF161098 40 134 1.02E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50205 2cb95ed12d9c8d8d946562db0d98b037 328 SUPERFAMILY SSF161098 175 311 1.02E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10965 d56cb0a1a633594007464b0f5e16e41f 316 Gene3D G3DSA:1.10.3720.10 78 303 9.1E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10965 d56cb0a1a633594007464b0f5e16e41f 316 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 103 302 6.1E-22 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10965 d56cb0a1a633594007464b0f5e16e41f 316 SUPERFAMILY SSF161098 72 296 1.07E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25805 db1e25dbb539010003b175524c4e6579 242 Gene3D G3DSA:3.20.20.380 4 218 3.8E-51 T 17-03-2017 IPR023648 Copper homeostasis CutC domain GO:0005507|GO:0055070 Reactome: R-HSA-936837 SHXM_RS25805 db1e25dbb539010003b175524c4e6579 242 SUPERFAMILY SSF110395 5 236 2.75E-44 T 17-03-2017 IPR023648 Copper homeostasis CutC domain GO:0005507|GO:0055070 Reactome: R-HSA-936837 SHXM_RS25805 db1e25dbb539010003b175524c4e6579 242 Pfam PF03932 CutC family 5 210 4.8E-25 T 17-03-2017 IPR005627 Copper homeostasis protein CutC GO:0005507|GO:0055070 Reactome: R-HSA-936837 SHXM_RS39350 a2e23ad456fe5d8e5d77d42fb86af3a4 478 ProSitePatterns PS00217 Sugar transport proteins signature 2. 139 164 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS39350 a2e23ad456fe5d8e5d77d42fb86af3a4 478 Gene3D G3DSA:1.20.1250.20 26 233 4.2E-23 T 17-03-2017 SHXM_RS39350 a2e23ad456fe5d8e5d77d42fb86af3a4 478 Gene3D G3DSA:1.20.1250.20 254 441 7.0E-16 T 17-03-2017 SHXM_RS39350 a2e23ad456fe5d8e5d77d42fb86af3a4 478 SUPERFAMILY SSF103473 18 437 3.01E-59 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS39350 a2e23ad456fe5d8e5d77d42fb86af3a4 478 ProSitePatterns PS00216 Sugar transport proteins signature 1. 89 105 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS39350 a2e23ad456fe5d8e5d77d42fb86af3a4 478 Pfam PF07690 Major Facilitator Superfamily 36 389 3.3E-26 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 Gene3D G3DSA:1.10.10.10 5 56 1.3E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 Pfam PF00455 DeoR C terminal sensor domain 76 233 9.5E-50 T 17-03-2017 IPR014036 DeoR C-terminal sensor domain SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 SUPERFAMILY SSF100950 76 235 3.35E-29 T 17-03-2017 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 Gene3D G3DSA:3.40.50.1360 77 227 7.2E-13 T 17-03-2017 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 SMART SM01134 73 234 2.8E-64 T 17-03-2017 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 SUPERFAMILY SSF46785 5 59 2.16E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 SMART SM00420 6 58 2.8E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 Pfam PF08220 DeoR-like helix-turn-helix domain 6 58 2.4E-14 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 38 56 6.3E-8 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 PRINTS PR00037 LacR bacterial regulatory protein HTH signature 24 38 6.3E-8 T 17-03-2017 IPR001034 DeoR-type HTH domain GO:0003700|GO:0005622|GO:0006355 SHXM_RS24715 e68bdeb41ba8eb68bdaf301f8bb56aa6 338 ProSitePatterns PS00894 DeoR-type HTH domain signature. 6 40 - T 17-03-2017 IPR018356 Transcription regulator, HTH DeoR-type, conserved site GO:0003700|GO:0006355 SHXM_RS37375 f8519a6c6fedaffe56880ed5b211205a 232 SMART SM01006 65 113 4.8E-10 T 17-03-2017 IPR019432 Siderophore biosynthesis protein, conserved domain SHXM_RS37375 f8519a6c6fedaffe56880ed5b211205a 232 Pfam PF13523 Acetyltransferase (GNAT) domain 70 214 9.1E-47 T 17-03-2017 SHXM_RS37375 f8519a6c6fedaffe56880ed5b211205a 232 Gene3D G3DSA:3.40.630.30 60 226 3.5E-47 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS37375 f8519a6c6fedaffe56880ed5b211205a 232 SUPERFAMILY SSF55729 60 226 5.6E-45 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS06025 c1e62595a72116ca4e906ecad34c4df1 300 SUPERFAMILY SSF89392 55 280 7.06E-27 T 17-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX SHXM_RS31795 25ff87982cafacfe6c70619775b1ba11 255 SUPERFAMILY SSF52096 3 253 3.56E-49 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS31795 25ff87982cafacfe6c70619775b1ba11 255 Gene3D G3DSA:3.90.226.10 3 225 6.9E-49 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS31795 25ff87982cafacfe6c70619775b1ba11 255 Pfam PF00378 Enoyl-CoA hydratase/isomerase 9 229 5.0E-37 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS26335 fa4afc3a810bc865e1b9c74d979048f2 308 SUPERFAMILY SSF52374 6 304 3.75E-88 T 17-03-2017 SHXM_RS26335 fa4afc3a810bc865e1b9c74d979048f2 308 TIGRFAM TIGR00018 panC: pantoate--beta-alanine ligase 23 300 1.9E-76 T 17-03-2017 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 SHXM_RS26335 fa4afc3a810bc865e1b9c74d979048f2 308 Gene3D G3DSA:3.40.50.620 4 177 4.8E-68 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS26335 fa4afc3a810bc865e1b9c74d979048f2 308 Pfam PF02569 Pantoate-beta-alanine ligase 4 300 3.9E-88 T 17-03-2017 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 SHXM_RS26335 fa4afc3a810bc865e1b9c74d979048f2 308 Gene3D G3DSA:3.30.1300.10 178 305 7.0E-33 T 17-03-2017 SHXM_RS26335 fa4afc3a810bc865e1b9c74d979048f2 308 Hamap MF_00158 Pantothenate synthetase [panC]. 2 302 38.141 T 17-03-2017 IPR003721 Pantoate-beta-alanine ligase GO:0004592|GO:0015940 KEGG: 00410+6.3.2.1|KEGG: 00770+6.3.2.1 SHXM_RS34805 1735da985755affaddd2ec4182bf0f28 132 SUPERFAMILY SSF54427 4 129 5.18E-32 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS34805 1735da985755affaddd2ec4182bf0f28 132 Pfam PF12680 SnoaL-like domain 9 116 3.8E-16 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS34805 1735da985755affaddd2ec4182bf0f28 132 Gene3D G3DSA:3.10.450.50 1 128 1.4E-29 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS09610 8e50af5582a7dd7c7363218b4ff400a6 313 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 146 161 - T 17-03-2017 IPR019826 Carboxylesterase type B, active site SHXM_RS09610 8e50af5582a7dd7c7363218b4ff400a6 313 SUPERFAMILY SSF53474 43 305 1.22E-80 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09610 8e50af5582a7dd7c7363218b4ff400a6 313 Gene3D G3DSA:3.40.50.1820 2 310 1.1E-102 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS09610 8e50af5582a7dd7c7363218b4ff400a6 313 Pfam PF07859 alpha/beta hydrolase fold 82 287 8.2E-76 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS38215 f52662db5209f0f5c43c21f7245fa368 135 Gene3D G3DSA:3.40.50.1010 68 124 7.0E-4 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS47820 02001a306c1148226631e7853965e083 274 SUPERFAMILY SSF88713 5 269 5.12E-44 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS47820 02001a306c1148226631e7853965e083 274 Gene3D G3DSA:3.20.20.370 4 269 2.2E-51 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS47820 02001a306c1148226631e7853965e083 274 Pfam PF01522 Polysaccharide deacetylase 53 161 3.0E-14 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS33075 6bdd93b3aaf90c8ebbc182214414182a 242 Pfam PF08279 HTH domain 6 59 6.4E-11 T 17-03-2017 IPR013196 Helix-turn-helix, type 11 SHXM_RS33075 6bdd93b3aaf90c8ebbc182214414182a 242 SUPERFAMILY SSF46785 1 62 2.6E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33075 6bdd93b3aaf90c8ebbc182214414182a 242 Gene3D G3DSA:1.10.10.10 1 59 1.3E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS33075 6bdd93b3aaf90c8ebbc182214414182a 242 Pfam PF13280 WYL domain 139 212 1.6E-17 T 17-03-2017 IPR026881 WYL domain SHXM_RS22825 a03c71486a4061953ba7e3f894bb2697 296 SUPERFAMILY SSF53335 22 242 7.94E-31 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22825 a03c71486a4061953ba7e3f894bb2697 296 Gene3D G3DSA:3.40.50.150 33 284 7.3E-68 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01205 cd2985efc42044160c0b81f4a8afc288 235 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 35 85 3.0E-13 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS01205 cd2985efc42044160c0b81f4a8afc288 235 Gene3D G3DSA:1.10.10.60 52 73 3.7E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01205 cd2985efc42044160c0b81f4a8afc288 235 Pfam PF13359 DDE superfamily endonuclease 125 230 1.1E-11 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS13865 c2e64d455a4eff708f760676ee4d1af7 296 SMART SM00530 10 82 5.6E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS13865 c2e64d455a4eff708f760676ee4d1af7 296 Gene3D G3DSA:1.10.260.40 3 79 7.5E-21 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13865 c2e64d455a4eff708f760676ee4d1af7 296 SUPERFAMILY SSF47413 31 78 1.13E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13865 c2e64d455a4eff708f760676ee4d1af7 296 Pfam PF13560 Helix-turn-helix domain 7 85 1.7E-16 T 17-03-2017 SHXM_RS24525 f3ce45c95247a65b45725198eeb7b515 437 SUPERFAMILY SSF53335 153 419 4.03E-81 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24525 f3ce45c95247a65b45725198eeb7b515 437 Pfam PF02353 Mycolic acid cyclopropane synthetase 143 415 1.4E-96 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24525 f3ce45c95247a65b45725198eeb7b515 437 SMART SM00828 Methyltransferase in polyketide synthase (PKS) enzymes. 162 403 5.6E-4 T 17-03-2017 IPR020803 Polyketide synthase, methyltransferase domain SHXM_RS24525 f3ce45c95247a65b45725198eeb7b515 437 PIRSF PIRSF003085 7 436 2.6E-134 T 17-03-2017 IPR003333 Mycolic acid cyclopropane synthase GO:0008610 SHXM_RS24525 f3ce45c95247a65b45725198eeb7b515 437 Gene3D G3DSA:3.40.50.150 143 417 5.2E-97 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26390 50e326944d8be77dcca310bdf25cd6fb 319 Gene3D G3DSA:3.40.190.10 268 319 1.1E-40 T 17-03-2017 SHXM_RS26390 50e326944d8be77dcca310bdf25cd6fb 319 Gene3D G3DSA:3.40.190.10 42 157 1.1E-40 T 17-03-2017 SHXM_RS26390 50e326944d8be77dcca310bdf25cd6fb 319 Gene3D G3DSA:3.40.190.120 158 255 2.1E-25 T 17-03-2017 SHXM_RS26390 50e326944d8be77dcca310bdf25cd6fb 319 SUPERFAMILY SSF53850 45 318 5.1E-44 T 17-03-2017 SHXM_RS26390 50e326944d8be77dcca310bdf25cd6fb 319 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 45 313 4.1E-50 T 17-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SHXM_RS10560 65f7d6d9ab9e92ca8a76986504b7ba8f 140 SUPERFAMILY SSF55298 21 137 1.73E-29 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS10560 65f7d6d9ab9e92ca8a76986504b7ba8f 140 Pfam PF01042 Endoribonuclease L-PSP 21 134 1.9E-19 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS10560 65f7d6d9ab9e92ca8a76986504b7ba8f 140 Gene3D G3DSA:3.30.1330.40 23 136 1.7E-32 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS18890 35f2e6b6b0ad709bccc3d80c8b7ba4c7 133 Gene3D G3DSA:3.40.50.2300 5 128 7.1E-11 T 17-03-2017 SHXM_RS18890 35f2e6b6b0ad709bccc3d80c8b7ba4c7 133 SUPERFAMILY SSF52172 6 129 1.71E-8 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS49575 d854b1b1d3ee3f9d2a61a9de8073e6f2 274 SUPERFAMILY SSF100950 6 266 2.09E-40 T 17-03-2017 SHXM_RS49575 d854b1b1d3ee3f9d2a61a9de8073e6f2 274 Pfam PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase 10 250 7.1E-10 T 17-03-2017 IPR006148 Glucosamine/galactosamine-6-phosphate isomerase GO:0005975 KEGG: 00520+3.5.99.6|MetaCyc: PWY-5514|MetaCyc: PWY-6855|MetaCyc: PWY-6906 SHXM_RS49575 d854b1b1d3ee3f9d2a61a9de8073e6f2 274 Gene3D G3DSA:3.40.50.1360 6 267 2.5E-48 T 17-03-2017 SHXM_RS25530 082e8510a74f1380dbb9bc74ea12e727 269 SUPERFAMILY SSF52540 18 238 6.89E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS25530 082e8510a74f1380dbb9bc74ea12e727 269 SMART SM00382 42 232 8.5E-11 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS25530 082e8510a74f1380dbb9bc74ea12e727 269 Pfam PF00005 ABC transporter 35 176 2.9E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS25530 082e8510a74f1380dbb9bc74ea12e727 269 Gene3D G3DSA:3.40.50.300 10 236 9.7E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29600 3d35dc5eb5d93726b1aa726ed9970408 257 Pfam PF10935 Protein of unknown function (DUF2637) 6 117 4.8E-21 T 17-03-2017 IPR021235 Protein of unknown function DUF2637 SHXM_RS17150 91b5094fb52c49d11ed5081721841792 318 SMART SM00382 67 256 5.7E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS17150 91b5094fb52c49d11ed5081721841792 318 Pfam PF00005 ABC transporter 60 206 3.8E-28 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS17150 91b5094fb52c49d11ed5081721841792 318 ProSitePatterns PS00211 ABC transporters family signature. 179 193 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS17150 91b5094fb52c49d11ed5081721841792 318 Gene3D G3DSA:3.40.50.300 46 278 4.4E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17150 91b5094fb52c49d11ed5081721841792 318 SUPERFAMILY SSF52540 43 269 9.86E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13270 fec0f520cb7dbafb72f415aaf7ec1ed4 288 Gene3D G3DSA:1.10.260.40 14 71 1.5E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13270 fec0f520cb7dbafb72f415aaf7ec1ed4 288 SUPERFAMILY SSF47413 12 70 3.66E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13270 fec0f520cb7dbafb72f415aaf7ec1ed4 288 Pfam PF13560 Helix-turn-helix domain 17 77 2.1E-13 T 17-03-2017 SHXM_RS13270 fec0f520cb7dbafb72f415aaf7ec1ed4 288 SMART SM00530 20 75 7.9E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 Pfam PF05787 Bacterial protein of unknown function (DUF839) 56 155 1.1E-15 T 17-03-2017 IPR008557 Protein of unknown function DUF839 SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 Pfam PF05787 Bacterial protein of unknown function (DUF839) 158 469 2.1E-65 T 17-03-2017 IPR008557 Protein of unknown function DUF839 SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 Gene3D G3DSA:2.120.10.30 317 463 1.0E-6 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 Gene3D G3DSA:2.120.10.30 230 259 1.0E-6 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 SUPERFAMILY SSF63829 299 310 2.16E-10 T 17-03-2017 SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 SUPERFAMILY SSF63829 343 466 2.16E-10 T 17-03-2017 SHXM_RS17770 dcb574b97902e68bfbf0c6fd2d840e01 482 SUPERFAMILY SSF63829 197 255 2.16E-10 T 17-03-2017 SHXM_RS38850 af897e5932bc28e28d62a7953c86771a 605 Pfam PF07905 Purine catabolism regulatory protein-like family 6 120 5.3E-26 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS38850 af897e5932bc28e28d62a7953c86771a 605 Pfam PF13556 PucR C-terminal helix-turn-helix domain 546 603 3.3E-21 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS39995 92ebe0dbb2bbd0cc043c033caca5e65d 400 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 203 395 1.2E-36 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS39995 92ebe0dbb2bbd0cc043c033caca5e65d 400 SUPERFAMILY SSF81606 189 394 1.07E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS39995 92ebe0dbb2bbd0cc043c033caca5e65d 400 Gene3D G3DSA:3.60.40.10 316 394 4.8E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS39995 92ebe0dbb2bbd0cc043c033caca5e65d 400 SMART SM00331 175 395 8.4E-17 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS03285 cc971242ea9b690ed64c0367d532cbb0 273 Pfam PF07398 MDMPI C-terminal domain 162 265 1.1E-10 T 17-03-2017 IPR010872 MDMPI C-terminal SHXM_RS03285 cc971242ea9b690ed64c0367d532cbb0 273 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 7 247 6.0E-23 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS03285 cc971242ea9b690ed64c0367d532cbb0 273 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 8 148 1.0E-16 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS03285 cc971242ea9b690ed64c0367d532cbb0 273 SUPERFAMILY SSF109854 8 153 4.58E-7 T 17-03-2017 SHXM_RS44200 d3ef05d267c0d97aa1653cc107ab6824 71 Pfam PF14216 Domain of unknown function (DUF4326) 24 42 2.0E-5 T 17-03-2017 IPR025475 Protein of unknown function DUF4326) SHXM_RS40050 195f7c65e83f8c968673477f1ee68ec7 165 SUPERFAMILY SSF49764 27 156 9.42E-32 T 17-03-2017 IPR008978 HSP20-like chaperone SHXM_RS40050 195f7c65e83f8c968673477f1ee68ec7 165 Gene3D G3DSA:2.60.40.790 24 157 2.9E-32 T 17-03-2017 IPR008978 HSP20-like chaperone SHXM_RS40050 195f7c65e83f8c968673477f1ee68ec7 165 Pfam PF00011 Hsp20/alpha crystallin family 59 156 2.7E-22 T 17-03-2017 IPR002068 Alpha crystallin/Hsp20 domain SHXM_RS24760 38c87d7f9c244dde28bfd13e7f6bdc3d 286 Gene3D G3DSA:3.40.605.10 5 254 3.1E-54 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS24760 38c87d7f9c244dde28bfd13e7f6bdc3d 286 SUPERFAMILY SSF53720 6 255 5.24E-45 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS24760 38c87d7f9c244dde28bfd13e7f6bdc3d 286 Pfam PF00171 Aldehyde dehydrogenase family 23 254 1.6E-41 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS17635 d1bc187d832122ca8d2b8f73684548db 269 Gene3D G3DSA:3.20.20.370 66 257 1.8E-64 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS17635 d1bc187d832122ca8d2b8f73684548db 269 Pfam PF01522 Polysaccharide deacetylase 71 190 1.7E-40 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS17635 d1bc187d832122ca8d2b8f73684548db 269 SUPERFAMILY SSF88713 68 257 3.11E-60 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS16985 3542fc894f79006b3e97c7d2b6e4df0c 68 Pfam PF05120 Gas vesicle protein G 4 65 5.8E-21 T 17-03-2017 IPR007804 Gas vesicle protein GvpG SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 ProSitePatterns PS00552 MerR-type HTH domain signature. 4 26 - T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 SUPERFAMILY SSF46955 1 113 2.2E-28 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 13 26 2.9E-8 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 2 13 2.9E-8 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 PRINTS PR00040 MerR bacterial regulatory protein HTH signature 37 57 2.9E-8 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 Gene3D G3DSA:1.10.1660.10 1 55 4.4E-26 T 17-03-2017 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 SMART SM00422 1 70 1.7E-33 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 Pfam PF13411 MerR HTH family regulatory protein 1 69 1.0E-18 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS43000 8688adabcbfb5022b534678d4a7e0b22 129 Gene3D G3DSA:1.10.1660.10 56 125 8.9E-12 T 17-03-2017 SHXM_RS24335 e67f0e402ac06a50afd7a94d18a7439a 508 SUPERFAMILY SSF103473 295 497 1.83E-27 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS24335 e67f0e402ac06a50afd7a94d18a7439a 508 SUPERFAMILY SSF103473 22 223 1.83E-27 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS24335 e67f0e402ac06a50afd7a94d18a7439a 508 Gene3D G3DSA:1.20.1250.20 40 214 9.2E-11 T 17-03-2017 SHXM_RS24335 e67f0e402ac06a50afd7a94d18a7439a 508 ProSitePatterns PS01023 PTR2 family proton/oligopeptide symporters signature 2. 168 180 - T 17-03-2017 IPR018456 PTR2 family proton/oligopeptide symporter, conserved site GO:0005215|GO:0006857|GO:0016020 Reactome: R-HSA-427975 SHXM_RS24335 e67f0e402ac06a50afd7a94d18a7439a 508 TIGRFAM TIGR00924 yjdL_sub1_fam: amino acid/peptide transporter (Peptide:H+ symporter) 17 504 1.4E-182 T 17-03-2017 IPR005279 Dipeptide/tripeptide permease GO:0015197|GO:0015833|GO:0016020 SHXM_RS24335 e67f0e402ac06a50afd7a94d18a7439a 508 Pfam PF00854 POT family 106 466 4.5E-61 T 17-03-2017 IPR000109 Proton-dependent oligopeptide transporter family GO:0005215|GO:0006810|GO:0016020 Reactome: R-HSA-427975 SHXM_RS24850 e62dbc19444d45d942e1ca3b87aae81e 431 Pfam PF02653 Branched-chain amino acid transport system / permease component 64 342 6.2E-33 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS43120 47dd1c81145a34d9c9e7fe52d7417cda 126 Gene3D G3DSA:3.40.30.10 34 122 1.6E-12 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS43120 47dd1c81145a34d9c9e7fe52d7417cda 126 Pfam PF00085 Thioredoxin 39 119 3.8E-7 T 17-03-2017 IPR013766 Thioredoxin domain GO:0045454 SHXM_RS43120 47dd1c81145a34d9c9e7fe52d7417cda 126 SUPERFAMILY SSF52833 38 122 7.97E-14 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS17955 3406280d209f0ffd533d5496f700e35f 141 Pfam PF00355 Rieske [2Fe-2S] domain 62 127 2.1E-18 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS17955 3406280d209f0ffd533d5496f700e35f 141 Gene3D G3DSA:2.102.10.10 6 136 2.7E-32 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS17955 3406280d209f0ffd533d5496f700e35f 141 PRINTS PR00162 Rieske 2Fe-2S subunit signature 98 110 4.5E-10 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS17955 3406280d209f0ffd533d5496f700e35f 141 PRINTS PR00162 Rieske 2Fe-2S subunit signature 78 89 4.5E-10 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS17955 3406280d209f0ffd533d5496f700e35f 141 PRINTS PR00162 Rieske 2Fe-2S subunit signature 111 123 4.5E-10 T 17-03-2017 IPR005805 Rieske iron-sulphur protein, C-terminal GO:0016020|GO:0055114 SHXM_RS17955 3406280d209f0ffd533d5496f700e35f 141 SUPERFAMILY SSF50022 43 137 1.7E-29 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS30660 6edf01bed40ccab9d2e27163c98b224f 174 SUPERFAMILY SSF55729 11 173 1.55E-29 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS30660 6edf01bed40ccab9d2e27163c98b224f 174 Pfam PF00583 Acetyltransferase (GNAT) family 68 147 5.6E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS30660 6edf01bed40ccab9d2e27163c98b224f 174 Gene3D G3DSA:3.40.630.30 11 173 2.2E-36 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 Pfam PF00266 Aminotransferase class-V 27 331 6.9E-19 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 SUPERFAMILY SSF53383 12 370 3.02E-78 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 PIRSF PIRSF000525 2 372 1.1E-76 T 17-03-2017 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|Reactome: R-HSA-977347 SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 TIGRFAM TIGR01366 serC_3: putative phosphoserine aminotransferase 11 371 2.8E-211 T 17-03-2017 IPR006272 Phosphoserine aminotransferase, Mycobacterial-type GO:0004648|GO:0006564|GO:0009058 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52 SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 Gene3D G3DSA:3.40.640.10 19 266 6.6E-52 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 Hamap MF_00160 Phosphoserine aminotransferase [serC]. 5 372 23.564 T 17-03-2017 IPR022278 Phosphoserine aminotransferase GO:0004648|GO:0006564 KEGG: 00260+2.6.1.52|KEGG: 00680+2.6.1.52|KEGG: 00750+2.6.1.52|Reactome: R-HSA-977347 SHXM_RS25650 03721c8b3a790eb343f7af3178360925 372 Gene3D G3DSA:3.90.1150.10 268 370 4.8E-5 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS01980 5efab14c5de833fcc42bcb5f775796a7 454 PIRSF PIRSF000337 6 447 1.3E-153 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS01980 5efab14c5de833fcc42bcb5f775796a7 454 SUPERFAMILY SSF51679 7 439 4.19E-124 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01980 5efab14c5de833fcc42bcb5f775796a7 454 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 13 433 3.9E-154 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS01980 5efab14c5de833fcc42bcb5f775796a7 454 Gene3D G3DSA:3.20.20.30 7 308 3.4E-127 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01980 5efab14c5de833fcc42bcb5f775796a7 454 Gene3D G3DSA:3.20.20.30 351 439 3.4E-127 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01980 5efab14c5de833fcc42bcb5f775796a7 454 Pfam PF00296 Luciferase-like monooxygenase 25 297 2.1E-60 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS48800 f118b246198e2671d7c8b6529e76e0a8 338 Pfam PF14690 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 34 76 5.9E-8 T 17-03-2017 IPR029261 Transposase IS204/IS1001/IS1096/IS1165, zinc-finger SHXM_RS48800 f118b246198e2671d7c8b6529e76e0a8 338 Pfam PF01610 Transposase 153 244 5.1E-18 T 17-03-2017 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SHXM_RS27605 64a8b7f36f2df8bedfb06619a9a2b33c 277 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 22 268 7.7E-44 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS27605 64a8b7f36f2df8bedfb06619a9a2b33c 277 SUPERFAMILY SSF51695 17 272 4.19E-64 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS27605 64a8b7f36f2df8bedfb06619a9a2b33c 277 Gene3D G3DSA:3.20.20.190 13 274 2.5E-75 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS35005 502af65153b4cc6b61476fc67a9c4423 477 Pfam PF13191 AAA ATPase domain 3 153 8.1E-8 T 17-03-2017 SHXM_RS35005 502af65153b4cc6b61476fc67a9c4423 477 Gene3D G3DSA:3.40.50.300 2 180 6.8E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35005 502af65153b4cc6b61476fc67a9c4423 477 SUPERFAMILY SSF52540 2 215 3.66E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35005 502af65153b4cc6b61476fc67a9c4423 477 Pfam PF03008 Archaea bacterial proteins of unknown function 327 421 4.1E-10 T 17-03-2017 IPR004256 Domain of unknown function DUF234, DEXX-box ATPase C-terminal SHXM_RS10920 af289f525af59609e53d38ea72dd6da3 339 SUPERFAMILY SSF53850 68 281 4.48E-37 T 17-03-2017 SHXM_RS10920 af289f525af59609e53d38ea72dd6da3 339 SMART SM00062 52 268 0.0023 T 17-03-2017 IPR001638 Solute-binding protein family 3/N-terminal domain of MltF SHXM_RS10920 af289f525af59609e53d38ea72dd6da3 339 Gene3D G3DSA:3.40.190.10 132 217 3.3E-22 T 17-03-2017 SHXM_RS10920 af289f525af59609e53d38ea72dd6da3 339 Pfam PF09084 NMT1/THI5 like 84 269 8.3E-17 T 17-03-2017 IPR015168 SsuA/THI5-like SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 Gene3D G3DSA:3.40.50.1820 381 501 1.3E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 Gene3D G3DSA:3.40.50.1820 198 322 1.3E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 Gene3D G3DSA:3.40.50.1820 67 154 1.3E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 SUPERFAMILY SSF53474 365 486 2.63E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 SUPERFAMILY SSF53474 97 155 2.63E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 SUPERFAMILY SSF53474 200 254 2.63E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26850 9bd815d3efe3d4fc1d0ac073fb487190 514 Pfam PF00561 alpha/beta hydrolase fold 103 486 1.1E-38 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS21185 a430ab5d65dc7caf3bf9a078f0a6f033 368 Gene3D G3DSA:3.20.20.80 134 306 3.2E-12 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS21185 a430ab5d65dc7caf3bf9a078f0a6f033 368 Pfam PF00704 Glycosyl hydrolases family 18 139 307 3.7E-7 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS21185 a430ab5d65dc7caf3bf9a078f0a6f033 368 SUPERFAMILY SSF51445 133 307 3.98E-13 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS16015 9aa8479c892260cd52f7d8f0355d9e80 283 Pfam PF04909 Amidohydrolase 5 281 8.8E-45 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS16015 9aa8479c892260cd52f7d8f0355d9e80 283 Gene3D G3DSA:3.20.20.140 3 282 1.5E-81 T 17-03-2017 SHXM_RS16015 9aa8479c892260cd52f7d8f0355d9e80 283 SUPERFAMILY SSF51556 4 281 1.85E-73 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS07295 ba24707647d570daea9be4137b2e0845 1214 Pfam PF02514 CobN/Magnesium Chelatase 100 1192 0.0 T 17-03-2017 IPR003672 CobN/magnesium chelatase GO:0009058 SHXM_RS07295 ba24707647d570daea9be4137b2e0845 1214 TIGRFAM TIGR02257 cobalto_cobN: cobaltochelatase, CobN subunit 43 1205 0.0 T 17-03-2017 IPR011953 Cobaltochelatase, CobN subunit GO:0009236|GO:0051116 SHXM_RS44070 35d3a9b415ed7b7c07796bf360e7cd39 126 Pfam PF13474 SnoaL-like domain 12 122 5.1E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS44070 35d3a9b415ed7b7c07796bf360e7cd39 126 Gene3D G3DSA:3.10.450.50 10 120 1.7E-14 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS44070 35d3a9b415ed7b7c07796bf360e7cd39 126 SUPERFAMILY SSF54427 10 120 9.89E-20 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS45795 1b40cffe078d8f129694c3154ce1644d 326 Gene3D G3DSA:3.40.830.10 1 195 2.3E-83 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS45795 1b40cffe078d8f129694c3154ce1644d 326 Gene3D G3DSA:3.40.830.10 233 323 2.3E-83 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS45795 1b40cffe078d8f129694c3154ce1644d 326 Pfam PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase 10 303 1.7E-35 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS45795 1b40cffe078d8f129694c3154ce1644d 326 SUPERFAMILY SSF53213 231 319 7.32E-63 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS45795 1b40cffe078d8f129694c3154ce1644d 326 SUPERFAMILY SSF53213 3 193 7.32E-63 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS37870 e95c57c9932baa13a9dc60dfaf49b5a4 651 Gene3D G3DSA:3.90.1200.10 355 414 1.2E-8 T 17-03-2017 SHXM_RS37870 e95c57c9932baa13a9dc60dfaf49b5a4 651 SUPERFAMILY SSF56112 186 248 1.55E-24 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS37870 e95c57c9932baa13a9dc60dfaf49b5a4 651 SUPERFAMILY SSF56112 290 408 1.55E-24 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS37870 e95c57c9932baa13a9dc60dfaf49b5a4 651 Pfam PF03109 ABC1 family 203 324 1.9E-29 T 17-03-2017 IPR004147 UbiB domain SHXM_RS16095 2838a9a2248e48a708125cf356079453 871 Gene3D G3DSA:3.40.50.300 775 837 1.3E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16095 2838a9a2248e48a708125cf356079453 871 Gene3D G3DSA:3.40.50.300 600 728 1.3E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16095 2838a9a2248e48a708125cf356079453 871 Pfam PF14490 Helix-hairpin-helix containing domain 274 357 2.5E-9 T 17-03-2017 IPR029493 RecD helicase-like helix-hairpin-helix domain SHXM_RS16095 2838a9a2248e48a708125cf356079453 871 SUPERFAMILY SSF52540 596 657 2.3E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16095 2838a9a2248e48a708125cf356079453 871 SUPERFAMILY SSF52540 698 842 2.3E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16095 2838a9a2248e48a708125cf356079453 871 Pfam PF13538 UvrD-like helicase C-terminal domain 786 834 9.5E-7 T 17-03-2017 IPR027785 UvrD-like helicase C-terminal domain SHXM_RS06550 6774fa980929e413b4d22794dac256af 108 SUPERFAMILY SSF142906 1 104 4.71E-22 T 17-03-2017 SHXM_RS06550 6774fa980929e413b4d22794dac256af 108 Pfam PF04237 YjbR 12 99 3.0E-19 T 17-03-2017 IPR007351 Uncharacterised protein YjbR SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 PRINTS PR00364 Disease resistance protein signature 336 351 2.3E-5 T 17-03-2017 SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 PRINTS PR00364 Disease resistance protein signature 413 427 2.3E-5 T 17-03-2017 SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 PRINTS PR00364 Disease resistance protein signature 519 533 2.3E-5 T 17-03-2017 SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 SUPERFAMILY SSF48452 51 219 9.28E-27 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 Pfam PF03704 Bacterial transcriptional activator domain 56 202 3.7E-31 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 Gene3D G3DSA:1.25.40.10 56 182 5.7E-7 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 SMART SM01043 56 202 4.6E-30 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 SUPERFAMILY SSF52540 304 583 3.8E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS44785 669dc0ad68c5c46f7d272863864bc3e0 1122 Gene3D G3DSA:1.25.40.10 780 1065 5.5E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 Gene3D G3DSA:3.40.50.1820 381 500 4.1E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 Gene3D G3DSA:3.40.50.1820 59 143 4.1E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 Gene3D G3DSA:3.40.50.1820 186 310 4.1E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 Pfam PF00561 alpha/beta hydrolase fold 95 271 5.2E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 Pfam PF08386 TAP-like protein 406 511 6.4E-20 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 SUPERFAMILY SSF53474 188 242 8.28E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 SUPERFAMILY SSF53474 363 476 8.28E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS11295 adaf19652be54064cf609efc8de735ea 518 SUPERFAMILY SSF53474 93 144 8.28E-20 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 Gene3D G3DSA:3.40.50.720 7 254 1.1E-84 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 147 175 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 87 98 1.7E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 140 148 1.7E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 160 179 1.7E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 SMART SM00822 This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group. 12 181 8.6E-4 T 17-03-2017 SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 18 253 7.7E-61 T 17-03-2017 SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 160 179 5.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 5.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 198 5.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 13 30 5.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 87 98 5.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 134 150 5.0E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24985 62939441f8aa1b71e2ea6297a1b9c4e3 256 SUPERFAMILY SSF51735 6 254 5.27E-81 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12340 6e5e1179a36450a28b0c153989bcacf2 107 SUPERFAMILY SSF46946 56 102 1.69E-7 T 17-03-2017 IPR010979 Ribosomal protein S13-like, H2TH GO:0003676 SHXM_RS12340 6e5e1179a36450a28b0c153989bcacf2 107 Gene3D G3DSA:1.10.8.50 50 102 8.2E-14 T 17-03-2017 SHXM_RS11900 8cfbacda0cabe8f9a8b9c89ceea15a81 120 Gene3D G3DSA:3.10.180.10 10 112 6.6E-12 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS11900 8cfbacda0cabe8f9a8b9c89ceea15a81 120 SUPERFAMILY SSF54593 6 116 2.34E-15 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS43140 68b712a624097d68459926fbc8f6969e 429 Gene3D G3DSA:3.20.20.60 101 304 5.3E-12 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS43140 68b712a624097d68459926fbc8f6969e 429 Pfam PF03328 HpcH/HpaI aldolase/citrate lyase family 126 294 1.8E-7 T 17-03-2017 IPR005000 HpcH/HpaI aldolase/citrate lyase domain GO:0003824 SHXM_RS43140 68b712a624097d68459926fbc8f6969e 429 SUPERFAMILY SSF51621 97 345 1.36E-14 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS33135 14765065795eeeb33e0ec6404ef553f6 68 Gene3D G3DSA:1.10.260.40 17 60 1.5E-4 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS33445 66514109b1dea700b896b1ba5092d744 234 SMART SM00858 41 103 0.0037 T 17-03-2017 IPR013974 SAF domain Reactome: R-HSA-4085001 SHXM_RS33445 66514109b1dea700b896b1ba5092d744 234 TIGRFAM TIGR03177 pilus_cpaB: Flp pilus assembly protein CpaB 10 215 9.4E-25 T 17-03-2017 IPR017592 Pilus assembly, Flp-type CpaB SHXM_RS33445 66514109b1dea700b896b1ba5092d744 234 Pfam PF16976 Flp pilus assembly protein RcpC/CpaB 107 212 1.7E-18 T 17-03-2017 IPR031571 Flp pilus assembly protein RcpC/CpaB domain SHXM_RS39800 502504225516db61b3eddca102be72ac 200 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 18 31 7.2E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39800 502504225516db61b3eddca102be72ac 200 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 39 62 7.2E-5 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS39800 502504225516db61b3eddca102be72ac 200 SUPERFAMILY SSF46689 6 81 1.8E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39800 502504225516db61b3eddca102be72ac 200 Gene3D G3DSA:1.10.357.10 4 194 5.5E-38 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS39800 502504225516db61b3eddca102be72ac 200 SUPERFAMILY SSF48498 88 177 1.45E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS39800 502504225516db61b3eddca102be72ac 200 Pfam PF13305 WHG domain 92 167 5.7E-11 T 17-03-2017 IPR025996 WHG domain SHXM_RS39800 502504225516db61b3eddca102be72ac 200 Pfam PF00440 Bacterial regulatory proteins, tetR family 18 64 3.0E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS20060 4738b31ee2158d50e4f6067d75d1b3de 230 Pfam PF04471 Restriction endonuclease 63 174 3.7E-23 T 17-03-2017 IPR007560 Restriction endonuclease type IV, Mrr GO:0003677|GO:0004519|GO:0009307 SHXM_RS20060 4738b31ee2158d50e4f6067d75d1b3de 230 SUPERFAMILY SSF52980 66 176 6.97E-20 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS20060 4738b31ee2158d50e4f6067d75d1b3de 230 Gene3D G3DSA:3.40.1350.10 56 180 5.6E-27 T 17-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 SHXM_RS23935 973c576948adf0953052d913bc43ffda 30 Pfam PF04149 Domain of unknown function (DUF397) 1 27 8.2E-9 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS01595 79bcc50d1848ff6b7cbb167eeea1a500 200 SUPERFAMILY SSF48498 83 198 7.79E-27 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS01595 79bcc50d1848ff6b7cbb167eeea1a500 200 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 59 9.1E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS01595 79bcc50d1848ff6b7cbb167eeea1a500 200 Gene3D G3DSA:1.10.357.10 54 198 1.9E-48 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS01595 79bcc50d1848ff6b7cbb167eeea1a500 200 Gene3D G3DSA:1.10.10.60 3 53 8.5E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS01595 79bcc50d1848ff6b7cbb167eeea1a500 200 SUPERFAMILY SSF46689 10 76 1.64E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS24180 02624468b36dca75ce263f4a1d674851 60 Gene3D G3DSA:2.20.25.10 10 58 5.8E-21 T 17-03-2017 SHXM_RS24180 02624468b36dca75ce263f4a1d674851 60 SUPERFAMILY SSF158997 1 58 4.71E-16 T 17-03-2017 SHXM_RS24180 02624468b36dca75ce263f4a1d674851 60 Pfam PF03966 Trm112p-like protein 7 47 1.6E-7 T 17-03-2017 IPR005651 Uncharacterised protein family UPF0434/Trm112 SHXM_RS39865 6d4ae26762ae94ba8f24832ee24e0552 340 Pfam PF01244 Membrane dipeptidase (Peptidase family M19) 7 336 1.7E-80 T 17-03-2017 IPR008257 Renal dipeptidase family GO:0006508|GO:0016805 MetaCyc: PWY-7533|Reactome: R-HSA-2142691|Reactome: R-HSA-5423646 SHXM_RS39865 6d4ae26762ae94ba8f24832ee24e0552 340 Gene3D G3DSA:3.20.20.140 8 336 7.0E-93 T 17-03-2017 SHXM_RS39865 6d4ae26762ae94ba8f24832ee24e0552 340 SUPERFAMILY SSF51556 8 338 1.11E-75 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS19180 4667bba152f17963dbc346bc08b4a438 146 Pfam PF03779 SPW repeat 37 84 6.9E-17 T 17-03-2017 IPR005530 SPW repeat SHXM_RS19180 4667bba152f17963dbc346bc08b4a438 146 Pfam PF03779 SPW repeat 93 138 1.8E-13 T 17-03-2017 IPR005530 SPW repeat SHXM_RS05200 e7beb61204c60b4222af08f395f58f64 243 SUPERFAMILY SSF53335 8 224 1.96E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS05200 e7beb61204c60b4222af08f395f58f64 243 Pfam PF13649 Methyltransferase domain 60 155 2.3E-17 T 17-03-2017 SHXM_RS05200 e7beb61204c60b4222af08f395f58f64 243 Gene3D G3DSA:3.40.50.150 19 217 7.0E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22125 6bcf822383bc08f8b5b70e24598e626f 340 Pfam PF00005 ABC transporter 28 171 1.1E-30 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS22125 6bcf822383bc08f8b5b70e24598e626f 340 Gene3D G3DSA:3.40.50.300 8 236 2.4E-71 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22125 6bcf822383bc08f8b5b70e24598e626f 340 ProSitePatterns PS00211 ABC transporters family signature. 144 158 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS22125 6bcf822383bc08f8b5b70e24598e626f 340 SUPERFAMILY SSF52540 11 233 4.79E-63 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22125 6bcf822383bc08f8b5b70e24598e626f 340 SMART SM00382 37 219 2.9E-14 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS32880 227ca5613a6ec354690ce248eb8f7715 55 SUPERFAMILY SSF54593 6 54 5.06E-8 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS32880 227ca5613a6ec354690ce248eb8f7715 55 Gene3D G3DSA:3.10.180.10 3 53 2.2E-6 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS20315 8eb908fe39872a738c19ea0466c8ab5e 82 Hamap MF_01217 Acyl carrier protein [acpP]. 7 81 17.921 T 17-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS20315 8eb908fe39872a738c19ea0466c8ab5e 82 Gene3D G3DSA:1.10.1200.10 3 81 5.9E-26 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS20315 8eb908fe39872a738c19ea0466c8ab5e 82 SUPERFAMILY SSF47336 2 81 6.02E-22 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS20315 8eb908fe39872a738c19ea0466c8ab5e 82 Pfam PF00550 Phosphopantetheine attachment site 11 77 5.4E-16 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS20315 8eb908fe39872a738c19ea0466c8ab5e 82 ProDom PD000887 CARRIER ACYL PHOSPHOPANTETHEINE ACP ACID FATTY BIOSYNTHESIS LIPID SYNTHESIS CHLOROPLAST 38 80 1.0E-16 T 17-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS20315 8eb908fe39872a738c19ea0466c8ab5e 82 TIGRFAM TIGR00517 acyl_carrier: acyl carrier protein 6 81 6.6E-21 T 17-03-2017 IPR003231 Acyl carrier protein (ACP) GO:0006633 Reactome: R-HSA-389661|Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS32220 5d9ac4ab01b97db60ecc628122086d9e 175 Pfam PF13529 Peptidase_C39 like family 27 139 2.6E-7 T 17-03-2017 SHXM_RS50420 96cc5ec5129a2b06f6708d5f643bbaed 502 Gene3D G3DSA:3.20.14.10 399 499 2.1E-5 T 17-03-2017 IPR015888 L-fucose isomerase, C-terminal GO:0005737|GO:0006004|GO:0008736 KEGG: 00051+5.3.1.25 SHXM_RS50420 96cc5ec5129a2b06f6708d5f643bbaed 502 SUPERFAMILY SSF53743 41 361 5.36E-72 T 17-03-2017 IPR009015 L-fucose isomerase, N-terminal/central domain GO:0005737|GO:0005996|GO:0016861 SHXM_RS50420 96cc5ec5129a2b06f6708d5f643bbaed 502 SUPERFAMILY SSF50443 359 501 1.2E-20 T 17-03-2017 IPR004216 L-fucose/L-arabinose isomerase, C-terminal SHXM_RS50420 96cc5ec5129a2b06f6708d5f643bbaed 502 Pfam PF02610 L-arabinose isomerase 60 372 9.9E-15 T 17-03-2017 IPR003762 L-arabinose isomerase GO:0008152|GO:0008733 KEGG: 00040+5.3.1.4 SHXM_RS42215 0341d92f03e0a0a4e1d1973416f526ff 298 Pfam PF13460 NAD(P)H-binding 8 195 8.6E-18 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42215 0341d92f03e0a0a4e1d1973416f526ff 298 Gene3D G3DSA:3.40.50.720 2 231 3.9E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42215 0341d92f03e0a0a4e1d1973416f526ff 298 SUPERFAMILY SSF51735 2 287 1.34E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15480 2095438fb2ed09c58e8a5d21fafe9b9f 246 SUPERFAMILY SSF48613 8 226 2.23E-36 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS15480 2095438fb2ed09c58e8a5d21fafe9b9f 246 Gene3D G3DSA:1.20.910.10 6 224 1.2E-34 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS15480 2095438fb2ed09c58e8a5d21fafe9b9f 246 Pfam PF03070 TENA/THI-4/PQQC family 17 223 1.0E-20 T 17-03-2017 IPR004305 Thiaminase-2/PQQC SHXM_RS48200 36adb9eab4db463931004522e5b94e70 790 SUPERFAMILY SSF48208 420 646 2.82E-10 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS50050 7044b7fab6654c6c93f2a9e86d4fb787 263 SUPERFAMILY SSF161098 7 263 1.78E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50050 7044b7fab6654c6c93f2a9e86d4fb787 263 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 78 257 2.8E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50050 7044b7fab6654c6c93f2a9e86d4fb787 263 Gene3D G3DSA:1.10.3720.10 8 250 9.7E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS41345 6764425b27db7c5bb32e8f49a5a6f2f2 278 Gene3D G3DSA:3.40.50.720 2 206 2.4E-31 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41345 6764425b27db7c5bb32e8f49a5a6f2f2 278 Pfam PF13460 NAD(P)H-binding 10 172 7.1E-13 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41345 6764425b27db7c5bb32e8f49a5a6f2f2 278 SUPERFAMILY SSF51735 3 269 3.66E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08545 c74a32a68c7f9eaf4055664d5e6cdb1d 234 Hamap MF_00336 ATP-dependent dethiobiotin synthetase BioD [bioD]. 1 202 24.723 T 17-03-2017 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380 SHXM_RS08545 c74a32a68c7f9eaf4055664d5e6cdb1d 234 PIRSF PIRSF006755 1 213 3.8E-39 T 17-03-2017 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380 SHXM_RS08545 c74a32a68c7f9eaf4055664d5e6cdb1d 234 Pfam PF13500 AAA domain 4 201 8.2E-37 T 17-03-2017 SHXM_RS08545 c74a32a68c7f9eaf4055664d5e6cdb1d 234 SUPERFAMILY SSF52540 1 202 2.13E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08545 c74a32a68c7f9eaf4055664d5e6cdb1d 234 Gene3D G3DSA:3.40.50.300 1 205 8.2E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS08545 c74a32a68c7f9eaf4055664d5e6cdb1d 234 TIGRFAM TIGR00347 bioD: dethiobiotin synthase 6 169 1.5E-32 T 17-03-2017 IPR004472 Dethiobiotin synthase BioD GO:0000287|GO:0004141|GO:0005524|GO:0009102 KEGG: 00780+6.3.3.3|MetaCyc: PWY-7380 SHXM_RS30975 fb01ae513d651df35563e77784bdec81 287 Gene3D G3DSA:3.30.2010.10 59 149 2.5E-30 T 17-03-2017 SHXM_RS30975 fb01ae513d651df35563e77784bdec81 287 Hamap MF_00188 Protease HtpX [htpX]. 7 282 27.765 T 17-03-2017 IPR022919 Peptidase M48, protease HtpX, putative GO:0004222 SHXM_RS30975 fb01ae513d651df35563e77784bdec81 287 Pfam PF01435 Peptidase family M48 70 282 1.5E-35 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS45700 07017400dbea4431eeb9d1ec76096c83 334 Gene3D G3DSA:1.10.3720.10 75 296 9.8E-45 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45700 07017400dbea4431eeb9d1ec76096c83 334 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 295 3.1E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45700 07017400dbea4431eeb9d1ec76096c83 334 TIGRFAM TIGR01726 HEQRo_perm_3TM: amino ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family 79 192 7.1E-16 T 17-03-2017 IPR010065 Amino acid ABC transporter, permease protein, 3-TM domain GO:0005215|GO:0006810|GO:0016021 SHXM_RS45700 07017400dbea4431eeb9d1ec76096c83 334 SUPERFAMILY SSF161098 79 283 3.4E-42 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23135 a0e9ab44351d35d0a9887c3e27e6951c 249 Pfam PF00196 Bacterial regulatory proteins, luxR family 189 234 5.2E-6 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS23135 a0e9ab44351d35d0a9887c3e27e6951c 249 SUPERFAMILY SSF46894 189 245 1.56E-10 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS23135 a0e9ab44351d35d0a9887c3e27e6951c 249 SMART SM00421 189 238 1.3E-4 T 17-03-2017 IPR000792 Transcription regulator LuxR, C-terminal GO:0006355 SHXM_RS23135 a0e9ab44351d35d0a9887c3e27e6951c 249 Gene3D G3DSA:1.10.10.10 189 243 1.6E-13 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS32600 c7ad9f342bd8eb1d058de29bb29cd93e 432 Pfam PF00144 Beta-lactamase 25 419 3.4E-65 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS32600 c7ad9f342bd8eb1d058de29bb29cd93e 432 SUPERFAMILY SSF56601 15 59 1.48E-62 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32600 c7ad9f342bd8eb1d058de29bb29cd93e 432 SUPERFAMILY SSF56601 87 423 1.48E-62 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32600 c7ad9f342bd8eb1d058de29bb29cd93e 432 Gene3D G3DSA:3.40.710.10 13 248 1.3E-75 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS32600 c7ad9f342bd8eb1d058de29bb29cd93e 432 Gene3D G3DSA:3.40.710.10 282 426 1.3E-75 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS00585 acaf3d228cd80d7fb23c3fabdc70692e 366 Gene3D G3DSA:3.40.50.150 10 228 2.4E-46 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00585 acaf3d228cd80d7fb23c3fabdc70692e 366 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 52 200 1.2E-29 T 17-03-2017 SHXM_RS00585 acaf3d228cd80d7fb23c3fabdc70692e 366 SUPERFAMILY SSF53335 60 196 1.32E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 148 176 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 SUPERFAMILY SSF51735 5 254 1.07E-72 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 13 253 5.0E-59 T 17-03-2017 SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 Gene3D G3DSA:3.40.50.720 2 254 2.0E-75 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 182 199 2.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 135 151 2.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 161 180 2.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 2.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05625 9012550c81af4e69ed1015bd17284551 256 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 216 236 2.7E-28 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS04590 5703a1a27a7b339548e60685d9a3302e 425 Pfam PF00999 Sodium/hydrogen exchanger family 15 400 1.3E-46 T 17-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SHXM_RS40235 3365b8c2194684e95f22f20d8c998367 316 Gene3D G3DSA:3.40.50.1820 5 314 2.0E-79 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40235 3365b8c2194684e95f22f20d8c998367 316 SUPERFAMILY SSF53474 25 314 2.61E-63 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40235 3365b8c2194684e95f22f20d8c998367 316 Pfam PF07859 alpha/beta hydrolase fold 86 292 7.3E-59 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS30505 ffbad975892bcc4a779fb0304ed2c406 206 Pfam PF00485 Phosphoribulokinase / Uridine kinase family 22 203 4.5E-5 T 17-03-2017 IPR006083 Phosphoribulokinase/uridine kinase GO:0005524|GO:0008152|GO:0016301 SHXM_RS30505 ffbad975892bcc4a779fb0304ed2c406 206 Gene3D G3DSA:3.40.50.300 4 204 1.5E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30505 ffbad975892bcc4a779fb0304ed2c406 206 SUPERFAMILY SSF52540 17 203 1.64E-34 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 Gene3D G3DSA:3.40.50.300 264 506 1.4E-46 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 Pfam PF00005 ABC transporter 20 171 5.4E-27 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 Pfam PF00005 ABC transporter 289 444 1.5E-16 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 SUPERFAMILY SSF52540 3 229 1.74E-54 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 Gene3D G3DSA:3.40.50.300 2 229 5.1E-60 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 SMART SM00382 29 219 1.9E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 SMART SM00382 297 500 9.3E-5 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 ProSitePatterns PS00211 ABC transporters family signature. 417 431 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS20385 2a3bfd9f0f7c1bc339e696d7d7705bb8 520 SUPERFAMILY SSF52540 269 506 1.96E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS19560 4a79dbab4ee95bd56737756f4d72781e 540 Pfam PF16655 PhoD-like phosphatase, N-terminal domain 58 155 3.8E-33 T 17-03-2017 IPR032093 Phospholipase D, N-terminal SHXM_RS19560 4a79dbab4ee95bd56737756f4d72781e 540 Pfam PF09423 PhoD-like phosphatase 168 509 2.4E-108 T 17-03-2017 IPR018946 Alkaline phosphatase D-related SHXM_RS19560 4a79dbab4ee95bd56737756f4d72781e 540 Gene3D G3DSA:3.60.21.10 167 511 6.9E-12 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS19560 4a79dbab4ee95bd56737756f4d72781e 540 SUPERFAMILY SSF56300 162 512 2.85E-29 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS46535 a451dad91dc5099fd8e2ea89615a656e 198 Pfam PF03358 NADPH-dependent FMN reductase 52 123 7.5E-9 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS46535 a451dad91dc5099fd8e2ea89615a656e 198 Gene3D G3DSA:3.40.50.360 5 193 6.6E-49 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS46535 a451dad91dc5099fd8e2ea89615a656e 198 SUPERFAMILY SSF52218 6 188 2.75E-35 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS40375 cafee673017b347b6969ea80cc9fcb21 329 Gene3D G3DSA:1.10.3720.10 33 318 1.4E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40375 cafee673017b347b6969ea80cc9fcb21 329 SUPERFAMILY SSF161098 85 314 3.92E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40375 cafee673017b347b6969ea80cc9fcb21 329 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 122 319 6.2E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS09665 3e598171d50f93aabd788ab6083ff9eb 414 ProSitePatterns PS01007 Transposases, Mutator family, signature. 244 268 - T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS09665 3e598171d50f93aabd788ab6083ff9eb 414 Pfam PF00872 Transposase, Mutator family 18 383 1.4E-49 T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS26190 2c0a51354485b929f2e5d214e0f49951 324 Gene3D G3DSA:3.40.190.10 85 181 2.8E-7 T 17-03-2017 SHXM_RS26190 2c0a51354485b929f2e5d214e0f49951 324 SUPERFAMILY SSF53850 5 131 4.46E-18 T 17-03-2017 SHXM_RS26190 2c0a51354485b929f2e5d214e0f49951 324 SUPERFAMILY SSF53850 162 312 4.46E-18 T 17-03-2017 SHXM_RS06525 04564667ff435c2a9d708aaec125f69e 523 Gene3D G3DSA:3.10.105.10 303 493 9.2E-29 T 17-03-2017 SHXM_RS06525 04564667ff435c2a9d708aaec125f69e 523 Pfam PF00496 Bacterial extracellular solute-binding proteins, family 5 Middle 82 444 5.5E-52 T 17-03-2017 IPR000914 Solute-binding protein family 5 domain SHXM_RS06525 04564667ff435c2a9d708aaec125f69e 523 Gene3D G3DSA:3.40.190.10 140 302 1.9E-26 T 17-03-2017 SHXM_RS06525 04564667ff435c2a9d708aaec125f69e 523 PIRSF PIRSF002741 1 516 9.1E-46 T 17-03-2017 IPR030678 Peptide/nickel binding protein, MppA-type GO:0043190|GO:0055085 SHXM_RS06525 04564667ff435c2a9d708aaec125f69e 523 SUPERFAMILY SSF53850 36 514 1.99E-82 T 17-03-2017 SHXM_RS02890 e27cc8d19a77164d76331adb852e09eb 432 Pfam PF01757 Acyltransferase family 48 392 2.6E-27 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS06570 052a0916b13ecb7196c3ec11a0a94a8d 300 SUPERFAMILY SSF56059 91 251 9.26E-25 T 17-03-2017 SHXM_RS06570 052a0916b13ecb7196c3ec11a0a94a8d 300 Gene3D G3DSA:3.30.470.20 166 252 9.8E-8 T 17-03-2017 IPR013816 ATP-grasp fold, subdomain 2 GO:0005524 SHXM_RS06570 052a0916b13ecb7196c3ec11a0a94a8d 300 Pfam PF08443 RimK-like ATP-grasp domain 90 251 9.5E-11 T 17-03-2017 IPR013651 ATP-grasp fold, RimK-type SHXM_RS06570 052a0916b13ecb7196c3ec11a0a94a8d 300 Gene3D G3DSA:3.30.1490.20 95 165 1.3E-10 T 17-03-2017 IPR013815 ATP-grasp fold, subdomain 1 GO:0003824|GO:0005524 SHXM_RS06570 052a0916b13ecb7196c3ec11a0a94a8d 300 ProSitePatterns PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 126 140 - T 17-03-2017 IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain GO:0005524 SHXM_RS06570 052a0916b13ecb7196c3ec11a0a94a8d 300 Gene3D G3DSA:3.40.50.20 3 94 4.6E-8 T 17-03-2017 IPR016185 Pre-ATP-grasp domain SHXM_RS16265 c0e6bb0252bfc08505db4af9f9d3cd22 292 SUPERFAMILY SSF51735 21 252 1.2E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16265 c0e6bb0252bfc08505db4af9f9d3cd22 292 Gene3D G3DSA:3.40.50.720 20 220 6.2E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16265 c0e6bb0252bfc08505db4af9f9d3cd22 292 Pfam PF13460 NAD(P)H-binding 27 185 4.8E-8 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11380 0ced2dae2bb0b84010a7ae28964ffe22 323 Pfam PF02653 Branched-chain amino acid transport system / permease component 36 300 2.9E-48 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS14395 e05bb2833bf722bb3e9c54fee3d35ca8 396 SUPERFAMILY SSF53335 102 226 3.57E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14395 e05bb2833bf722bb3e9c54fee3d35ca8 396 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 97 250 1.1E-21 T 17-03-2017 SHXM_RS14395 e05bb2833bf722bb3e9c54fee3d35ca8 396 Gene3D G3DSA:3.40.50.150 24 256 6.5E-47 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS19000 69de6d695d5c19a941f1da763ae2d4de 349 Pfam PF02654 Cobalamin-5-phosphate synthase 102 344 1.2E-45 T 17-03-2017 IPR003805 Adenosylcobinamide-GDP ribazoletransferase GO:0008818|GO:0009236|GO:0051073 KEGG: 00860+2.7.8.26|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS19000 69de6d695d5c19a941f1da763ae2d4de 349 Hamap MF_00719 Adenosylcobinamide-GDP ribazoletransferase [cobS]. 52 349 39.845 T 17-03-2017 IPR003805 Adenosylcobinamide-GDP ribazoletransferase GO:0008818|GO:0009236|GO:0051073 KEGG: 00860+2.7.8.26|MetaCyc: PWY-5508|MetaCyc: PWY-5509|MetaCyc: PWY-6269 SHXM_RS11675 a3fb4bcab6b3fa3138c54a20040cf463 339 Pfam PF14224 Domain of unknown function (DUF4331) 15 251 1.3E-24 T 17-03-2017 IPR025566 Protein of unknown function DUF4331 SHXM_RS22270 a504534415f96c9ed6f5da424202c017 356 Pfam PF02653 Branched-chain amino acid transport system / permease component 66 342 1.7E-55 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS26465 f163e0f4ba8b92e91a27701bd0fce7f6 380 TIGRFAM TIGR03883 DUF2342_F420: uncharacterized protein, coenzyme F420 biosynthesis associated 10 375 8.4E-140 T 17-03-2017 IPR022454 Conserved hypothetical protein CHP03883, F420 biosynthesis associated SHXM_RS26465 f163e0f4ba8b92e91a27701bd0fce7f6 380 SUPERFAMILY SSF55486 9 374 2.05E-105 T 17-03-2017 SHXM_RS26465 f163e0f4ba8b92e91a27701bd0fce7f6 380 TIGRFAM TIGR03624 TIGR03624: putative hydrolase 10 375 2.9E-122 T 17-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 SHXM_RS26465 f163e0f4ba8b92e91a27701bd0fce7f6 380 Pfam PF10103 Zinicin-like metallopeptidase 10 371 6.7E-122 T 17-03-2017 IPR018766 Zinicin-like metallopeptidase type 2 SHXM_RS34135 5294f32b4897f83689297482116028c5 427 SUPERFAMILY SSF50346 11 88 1.33E-5 T 17-03-2017 IPR011033 PRC-barrel-like SHXM_RS34135 5294f32b4897f83689297482116028c5 427 Pfam PF00571 CBS domain 282 343 5.4E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS34135 5294f32b4897f83689297482116028c5 427 Pfam PF00571 CBS domain 355 405 5.1E-7 T 17-03-2017 IPR000644 CBS domain SHXM_RS34135 5294f32b4897f83689297482116028c5 427 SUPERFAMILY SSF158791 166 278 5.89E-30 T 17-03-2017 SHXM_RS34135 5294f32b4897f83689297482116028c5 427 SMART SM00924 178 281 5.2E-35 T 17-03-2017 IPR006668 Magnesium transporter, MgtE intracellular domain SHXM_RS34135 5294f32b4897f83689297482116028c5 427 Pfam PF03448 MgtE intracellular N domain 178 278 3.9E-27 T 17-03-2017 IPR006668 Magnesium transporter, MgtE intracellular domain SHXM_RS34135 5294f32b4897f83689297482116028c5 427 Gene3D G3DSA:1.25.60.10 164 276 4.2E-39 T 17-03-2017 SHXM_RS34135 5294f32b4897f83689297482116028c5 427 Gene3D G3DSA:3.10.580.10 280 405 3.6E-19 T 17-03-2017 SHXM_RS34135 5294f32b4897f83689297482116028c5 427 SMART SM00116 357 405 2.2E-6 T 17-03-2017 IPR000644 CBS domain SHXM_RS34135 5294f32b4897f83689297482116028c5 427 SUPERFAMILY SSF54631 281 417 2.56E-24 T 17-03-2017 SHXM_RS32900 806d3a15c7ea4f4cd440fb83a1ce04c9 104 Pfam PF05121 Gas vesicle protein K 18 101 6.2E-37 T 17-03-2017 IPR007805 Gas vesicle protein GvpK GO:0031412 SHXM_RS18550 ed7c8f29203a069c92adad304508623c 246 Pfam PF02578 Multi-copper polyphenol oxidoreductase laccase 16 243 3.3E-70 T 17-03-2017 IPR003730 Multi-copper polyphenol oxidoreductase, laccase SHXM_RS18550 ed7c8f29203a069c92adad304508623c 246 SUPERFAMILY SSF64438 8 244 1.33E-74 T 17-03-2017 IPR011324 Cytotoxic necrotizing factor-like, catalytic SHXM_RS18550 ed7c8f29203a069c92adad304508623c 246 TIGRFAM TIGR00726 TIGR00726: YfiH family protein 21 244 7.9E-47 T 17-03-2017 IPR003730 Multi-copper polyphenol oxidoreductase, laccase SHXM_RS18550 ed7c8f29203a069c92adad304508623c 246 Gene3D G3DSA:3.60.140.10 6 244 1.1E-83 T 17-03-2017 IPR003730 Multi-copper polyphenol oxidoreductase, laccase SHXM_RS47720 0c47950aacde2398f92a6f897c208d69 289 SUPERFAMILY SSF51735 1 101 1.97E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS47720 0c47950aacde2398f92a6f897c208d69 289 Pfam PF02558 Ketopantoate reductase PanE/ApbA 4 131 5.6E-16 T 17-03-2017 IPR013332 Ketopantoate reductase, N-terminal domain GO:0008677|GO:0055114 KEGG: 00052+1.1.1.16|KEGG: 00770+1.1.1.169|MetaCyc: PWY-6654 SHXM_RS47720 0c47950aacde2398f92a6f897c208d69 289 Gene3D G3DSA:3.40.50.720 1 174 1.0E-27 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04900 90ca86e8ebe62eb7fcf96a75f3ce0ee5 463 SMART SM01150 8 406 4.3E-173 T 17-03-2017 IPR009770 Domain of unknown function DUF1338 SHXM_RS04900 90ca86e8ebe62eb7fcf96a75f3ce0ee5 463 Pfam PF07063 Domain of unknown function (DUF1338) 6 406 1.4E-99 T 17-03-2017 IPR009770 Domain of unknown function DUF1338 SHXM_RS00135 da12ab10825025ebd5a8dba182d54068 296 SUPERFAMILY SSF52151 1 284 1.05E-47 T 17-03-2017 IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase GO:0008152 SHXM_RS00135 da12ab10825025ebd5a8dba182d54068 296 Pfam PF01734 Patatin-like phospholipase 2 171 8.3E-21 T 17-03-2017 IPR002641 Patatin/Phospholipase A2-related GO:0006629 SHXM_RS00135 da12ab10825025ebd5a8dba182d54068 296 Gene3D G3DSA:3.40.1090.10 2 266 8.3E-66 T 17-03-2017 SHXM_RS30205 317daace7deb711cedbe83adab83cc60 368 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 89 239 3.5E-28 T 17-03-2017 SHXM_RS30205 317daace7deb711cedbe83adab83cc60 368 SUPERFAMILY SSF53335 11 207 6.99E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS30205 317daace7deb711cedbe83adab83cc60 368 Gene3D G3DSA:3.40.50.150 16 255 2.3E-53 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06690 77ad0a18043e33268b8ce36da85f2809 165 Gene3D G3DSA:1.20.1290.10 13 160 2.1E-48 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS06690 77ad0a18043e33268b8ce36da85f2809 165 Pfam PF02627 Carboxymuconolactone decarboxylase family 20 106 3.7E-19 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS06690 77ad0a18043e33268b8ce36da85f2809 165 TIGRFAM TIGR00778 ahpD_dom: alkylhydroperoxidase AhpD family core domain 43 89 1.2E-17 T 17-03-2017 IPR004675 Alkylhydroperoxidase AhpD core GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS06690 77ad0a18043e33268b8ce36da85f2809 165 SUPERFAMILY SSF69118 15 157 2.22E-40 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS36555 c8e831d320d5e9270fa3a0945cded9a8 302 Gene3D G3DSA:3.40.50.150 32 230 1.1E-12 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36555 c8e831d320d5e9270fa3a0945cded9a8 302 Pfam PF02353 Mycolic acid cyclopropane synthetase 40 98 1.9E-4 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS36555 c8e831d320d5e9270fa3a0945cded9a8 302 SUPERFAMILY SSF53335 27 231 2.63E-16 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11365 0e183cd96d24c375b7102ca1c6001e16 476 Pfam PF15892 BNR repeat-containing family member 74 382 1.1E-85 T 17-03-2017 SHXM_RS29170 67da1bf9b508d0ea6b33fa02e3a47be6 109 Pfam PF02342 TerD domain 25 95 4.3E-9 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS29170 67da1bf9b508d0ea6b33fa02e3a47be6 109 Gene3D G3DSA:2.60.60.30 27 96 4.4E-7 T 17-03-2017 SHXM_RS15285 56ae13e09b3529792351336938031ac8 370 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 4 347 1.2E-73 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS15285 56ae13e09b3529792351336938031ac8 370 SUPERFAMILY SSF51395 2 360 4.97E-115 T 17-03-2017 SHXM_RS15285 56ae13e09b3529792351336938031ac8 370 Gene3D G3DSA:3.20.20.70 2 360 2.9E-131 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS05105 8560fd58ded036a0089041743c3fc1f2 242 Pfam PF09859 Oxygenase, catalysing oxidative methylation of damaged DNA 70 241 1.2E-77 T 17-03-2017 IPR018655 Protein of unknown function DUF2086 SHXM_RS38145 01864404b6a8a8a456804429c70e3780 256 Pfam PF02585 GlcNAc-PI de-N-acetylase 5 141 2.6E-22 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS38145 01864404b6a8a8a456804429c70e3780 256 Gene3D G3DSA:3.40.50.10320 2 245 1.3E-52 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS38145 01864404b6a8a8a456804429c70e3780 256 SUPERFAMILY SSF102588 2 233 1.28E-46 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS38505 af477cab0472dbd076951e6becd26728 302 Pfam PF00583 Acetyltransferase (GNAT) family 220 292 1.7E-5 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS38505 af477cab0472dbd076951e6becd26728 302 Gene3D G3DSA:3.40.630.30 3 69 2.5E-9 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38505 af477cab0472dbd076951e6becd26728 302 Gene3D G3DSA:3.40.630.30 229 298 2.5E-9 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38505 af477cab0472dbd076951e6becd26728 302 SUPERFAMILY SSF55729 132 295 1.36E-12 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS38505 af477cab0472dbd076951e6becd26728 302 SUPERFAMILY SSF55729 40 99 1.36E-12 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 SUPERFAMILY SSF51735 27 271 8.66E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 Pfam PF00106 short chain dehydrogenase 30 228 8.0E-29 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 104 115 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 235 255 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 165 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 209 226 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 31 48 3.3E-21 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24400 e7d56a6bcfff681344eb6ab18080fc28 313 Gene3D G3DSA:3.40.50.720 26 266 1.9E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22290 c25067c2454945de095b8441206a6d92 69 SUPERFAMILY SSF46955 5 56 5.04E-9 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS22290 c25067c2454945de095b8441206a6d92 69 Pfam PF13411 MerR HTH family regulatory protein 9 47 4.1E-6 T 17-03-2017 IPR000551 MerR-type HTH domain GO:0003677|GO:0006355 SHXM_RS22290 c25067c2454945de095b8441206a6d92 69 Gene3D G3DSA:1.10.1660.10 8 42 3.4E-6 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 SUPERFAMILY SSF103473 22 213 1.31E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 SUPERFAMILY SSF103473 480 512 1.31E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 SUPERFAMILY SSF103473 262 432 1.31E-72 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 PRINTS PR01036 Tetracycline resistance protein TetB signature 413 432 1.5E-5 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 PRINTS PR01036 Tetracycline resistance protein TetB signature 87 109 1.5E-5 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 PRINTS PR01036 Tetracycline resistance protein TetB signature 371 391 1.5E-5 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 PRINTS PR01036 Tetracycline resistance protein TetB signature 148 172 1.5E-5 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 Gene3D G3DSA:1.20.1250.20 276 433 9.5E-21 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 Gene3D G3DSA:1.20.1250.20 481 508 9.5E-21 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 Gene3D G3DSA:1.20.1250.20 22 206 1.2E-34 T 17-03-2017 SHXM_RS32850 6760014d9c4c62fc1f3490dcbafcec68 520 Pfam PF07690 Major Facilitator Superfamily 29 423 2.1E-48 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS08485 e4d8b3f591b15cb806a8a567d75f574f 104 Gene3D G3DSA:3.40.1620.10 3 52 2.9E-15 T 17-03-2017 IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM SHXM_RS08485 e4d8b3f591b15cb806a8a567d75f574f 104 SUPERFAMILY SSF143120 5 55 5.36E-12 T 17-03-2017 SHXM_RS08485 e4d8b3f591b15cb806a8a567d75f574f 104 TIGRFAM TIGR01552 phd_fam: prevent-host-death family protein 4 55 3.6E-17 T 17-03-2017 IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM SHXM_RS08485 e4d8b3f591b15cb806a8a567d75f574f 104 Pfam PF02604 Antitoxin Phd_YefM, type II toxin-antitoxin system 5 55 9.9E-15 T 17-03-2017 IPR006442 Type II toxin-antitoxin system, antitoxin Phd/YefM SHXM_RS08530 7f5c80c6e77dcf9059812433895b90ef 401 Gene3D G3DSA:3.90.1150.10 286 396 6.2E-13 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS08530 7f5c80c6e77dcf9059812433895b90ef 401 Gene3D G3DSA:3.40.640.10 55 285 7.4E-80 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS08530 7f5c80c6e77dcf9059812433895b90ef 401 ProSitePatterns PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 249 258 - T 17-03-2017 IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site GO:0008152|GO:0016740 SHXM_RS08530 7f5c80c6e77dcf9059812433895b90ef 401 SUPERFAMILY SSF53383 34 396 2.39E-94 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS08530 7f5c80c6e77dcf9059812433895b90ef 401 Pfam PF00155 Aminotransferase class I and II 38 394 1.9E-56 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS18495 34d2450e07c7a3dfc2f8bc59bd33cdb9 196 SUPERFAMILY SSF53474 8 194 1.8E-28 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS18495 34d2450e07c7a3dfc2f8bc59bd33cdb9 196 Gene3D G3DSA:3.40.50.1820 9 193 2.7E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS18495 34d2450e07c7a3dfc2f8bc59bd33cdb9 196 Pfam PF01738 Dienelactone hydrolase family 8 193 2.9E-24 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS36445 8a2c1945fe009c2aa262cb7b28c6f121 207 Pfam PF02620 Uncharacterized ACR, COG1399 66 184 6.4E-32 T 17-03-2017 IPR003772 Protein of unknown function DUF177 SHXM_RS22255 c624236ffb4ff50497a689d40988beb1 295 SUPERFAMILY SSF51569 29 281 8.79E-35 T 17-03-2017 SHXM_RS22255 c624236ffb4ff50497a689d40988beb1 295 Gene3D G3DSA:3.20.20.70 29 282 3.3E-37 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS01480 288aad64b84bbfb40058b62ae4378c01 650 Pfam PF10022 Uncharacterized protein conserved in bacteria (DUF2264) 14 363 4.2E-107 T 17-03-2017 IPR016624 Uncharacterised conserved protein UCP014753 SHXM_RS01755 fdcd7d0f140b4e85241f57b3f9e4dfcc 326 Pfam PF00248 Aldo/keto reductase family 16 313 2.1E-64 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS01755 fdcd7d0f140b4e85241f57b3f9e4dfcc 326 Gene3D G3DSA:3.20.20.100 14 323 5.0E-83 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS01755 fdcd7d0f140b4e85241f57b3f9e4dfcc 326 SUPERFAMILY SSF51430 12 318 1.09E-82 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS01755 fdcd7d0f140b4e85241f57b3f9e4dfcc 326 PRINTS PR00069 Aldo-keto reductase signature 40 64 9.1E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS01755 fdcd7d0f140b4e85241f57b3f9e4dfcc 326 PRINTS PR00069 Aldo-keto reductase signature 135 152 9.1E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS01755 fdcd7d0f140b4e85241f57b3f9e4dfcc 326 PRINTS PR00069 Aldo-keto reductase signature 104 122 9.1E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS23320 060959baad5384382c256fdad48542d1 525 Pfam PF04286 Protein of unknown function (DUF445) 160 521 1.6E-98 T 17-03-2017 IPR007383 Protein of unknown function DUF445 SHXM_RS07715 3a24993d299e444932c1d9a17e044f9d 220 SUPERFAMILY SSF53271 1 208 9.83E-49 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS07715 3a24993d299e444932c1d9a17e044f9d 220 Gene3D G3DSA:3.40.50.2020 3 61 2.5E-38 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS07715 3a24993d299e444932c1d9a17e044f9d 220 Gene3D G3DSA:3.40.50.2020 94 203 2.5E-38 T 17-03-2017 IPR029057 Phosphoribosyltransferase-like SHXM_RS07715 3a24993d299e444932c1d9a17e044f9d 220 Pfam PF00156 Phosphoribosyl transferase domain 17 194 3.6E-19 T 17-03-2017 IPR000836 Phosphoribosyltransferase domain GO:0009116 SHXM_RS47340 9cc359dba308b3c3de4d771bbfce9a06 199 Gene3D G3DSA:3.40.630.30 63 160 8.2E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS47340 9cc359dba308b3c3de4d771bbfce9a06 199 SUPERFAMILY SSF55729 49 163 4.79E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS47340 9cc359dba308b3c3de4d771bbfce9a06 199 Pfam PF13302 Acetyltransferase (GNAT) domain 70 156 1.3E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 Pfam PF04055 Radical SAM superfamily 157 327 5.4E-30 T 17-03-2017 IPR007197 Radical SAM GO:0003824|GO:0051536 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 Hamap MF_01864 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase [miaB]. 7 450 68.354 T 17-03-2017 IPR006463 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase MiaB GO:0005737|GO:0006400|GO:0016740|GO:0051539 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 TIGRFAM TIGR01574 miaB-methiolase: tRNA-i(6)A37 thiotransferase enzyme MiaB 9 446 5.3E-146 T 17-03-2017 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 SMART SM00729 153 371 5.0E-60 T 17-03-2017 IPR006638 Elongator protein 3/MiaB/NifB GO:0003824|GO:0051536 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 SUPERFAMILY SSF102114 139 379 9.94E-59 T 17-03-2017 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 Pfam PF00919 Uncharacterized protein family UPF0004 10 110 6.8E-26 T 17-03-2017 IPR013848 Methylthiotransferase, N-terminal GO:0003824|GO:0009451|GO:0051539 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 Gene3D G3DSA:3.80.30.20 153 384 1.2E-85 T 17-03-2017 IPR023404 Radical SAM, alpha/beta horseshoe SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 TIGRFAM TIGR00089 TIGR00089: radical SAM methylthiotransferase, MiaB/RimO family 9 445 3.7E-154 T 17-03-2017 IPR005839 Methylthiotransferase GO:0016740|GO:0043412|GO:0051539 SHXM_RS37310 3bbc2cb5eb5b6a6723f2e1380ccd9ada 500 ProSitePatterns PS01278 Methylthiotransferase radical SAM domain signature. 157 177 - T 17-03-2017 IPR020612 Methylthiotransferase, conserved site GO:0051539 SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 Pfam PF07687 Peptidase dimerisation domain 203 362 4.3E-21 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 Pfam PF01546 Peptidase family M20/M25/M40 90 458 1.9E-33 T 17-03-2017 IPR002933 Peptidase M20 GO:0008152|GO:0016787 SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 Gene3D G3DSA:3.40.630.10 10 200 4.1E-66 T 17-03-2017 SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 Gene3D G3DSA:3.40.630.10 376 463 4.1E-66 T 17-03-2017 SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 Gene3D G3DSA:3.30.70.360 206 369 2.2E-53 T 17-03-2017 IPR011650 Peptidase M20, dimerisation domain SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 SUPERFAMILY SSF53187 377 463 1.26E-63 T 17-03-2017 SHXM_RS34285 b8c57e4949369f53b09bbd03ce39baf2 469 SUPERFAMILY SSF53187 10 206 1.26E-63 T 17-03-2017 SHXM_RS34755 e7c07fd0d61f6d13d62fced7f25af892 250 ProSitePatterns PS00211 ABC transporters family signature. 147 161 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS34755 e7c07fd0d61f6d13d62fced7f25af892 250 SUPERFAMILY SSF52540 1 245 1.03E-79 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34755 e7c07fd0d61f6d13d62fced7f25af892 250 Gene3D G3DSA:3.40.50.300 1 247 1.1E-82 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS34755 e7c07fd0d61f6d13d62fced7f25af892 250 Pfam PF00005 ABC transporter 17 175 2.1E-32 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS34755 e7c07fd0d61f6d13d62fced7f25af892 250 PIRSF PIRSF039085 1 250 1.3E-124 T 17-03-2017 IPR030679 ABC-type amino acid transport system, ATPase component, HisP-type GO:0003333|GO:0015424 SHXM_RS34755 e7c07fd0d61f6d13d62fced7f25af892 250 SMART SM00382 26 223 2.3E-17 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 Pfam PF00356 Bacterial regulatory proteins, lacI family 14 59 7.3E-13 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 Gene3D G3DSA:1.10.260.40 11 62 1.8E-19 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 Pfam PF13377 Periplasmic binding protein-like domain 178 337 2.8E-36 T 17-03-2017 SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 SMART SM00354 12 81 1.4E-14 T 17-03-2017 IPR000843 LacI-type HTH domain GO:0003677|GO:0006355 SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 Gene3D G3DSA:3.40.50.2300 183 318 5.4E-41 T 17-03-2017 SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 SUPERFAMILY SSF53822 79 339 2.36E-54 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 Gene3D G3DSA:3.40.50.2300 63 182 2.1E-25 T 17-03-2017 SHXM_RS04800 b00d705f03b6a9c7e90bfe6054b613dd 341 SUPERFAMILY SSF47413 11 70 9.38E-15 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS39215 0ff7d94007644f8795a542e42fc9def9 287 Gene3D G3DSA:3.90.1200.10 111 236 4.2E-14 T 17-03-2017 SHXM_RS39215 0ff7d94007644f8795a542e42fc9def9 287 SUPERFAMILY SSF56112 26 243 6.56E-24 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS39215 0ff7d94007644f8795a542e42fc9def9 287 Pfam PF01636 Phosphotransferase enzyme family 31 241 1.4E-22 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS01880 8b929a534c73cc2ba27b6cdcbaa6d544 194 Gene3D G3DSA:3.40.50.360 5 188 3.9E-54 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS01880 8b929a534c73cc2ba27b6cdcbaa6d544 194 SUPERFAMILY SSF52218 6 185 8.52E-42 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS01880 8b929a534c73cc2ba27b6cdcbaa6d544 194 Pfam PF03358 NADPH-dependent FMN reductase 15 125 1.3E-10 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS09060 3249ec62f35350a84e5825ae7bf7b6c2 171 SUPERFAMILY SSF53098 70 126 1.21E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS30550 bed905eb84ee9c0d0b58e60e176aac2a 397 SUPERFAMILY SSF103365 11 397 1.57E-129 T 17-03-2017 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 Reactome: R-HSA-6784531 SHXM_RS30550 bed905eb84ee9c0d0b58e60e176aac2a 397 Pfam PF01139 tRNA-splicing ligase RtcB 29 397 2.1E-129 T 17-03-2017 IPR001233 tRNA-splicing ligase, RtcB GO:0006396|GO:0008452 Reactome: R-HSA-6784531 SHXM_RS14285 2584158c6cdde36bed17add745f2e022 152 Gene3D G3DSA:3.10.180.10 8 152 4.0E-26 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS14285 2584158c6cdde36bed17add745f2e022 152 SUPERFAMILY SSF54593 7 152 3.3E-15 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 Pfam PF05048 Periplasmic copper-binding protein (NosD) 124 295 4.0E-14 T 17-03-2017 IPR007742 Periplasmic copper-binding protein NosD, beta helix domain SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SUPERFAMILY SSF51126 7 315 7.54E-38 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 Gene3D G3DSA:2.160.20.10 8 297 4.1E-31 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 278 312 2300.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 250 272 22.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 185 206 1100.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 67 89 3.7 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 215 249 9500.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 137 159 12.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS14425 72019123f2f758f8661d7e9208138575 405 SMART SM00710 114 136 1900.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS30005 688b839d9c8a147793bf213ff474b412 293 Pfam PF00248 Aldo/keto reductase family 23 289 1.5E-40 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS30005 688b839d9c8a147793bf213ff474b412 293 PRINTS PR00069 Aldo-keto reductase signature 52 76 5.3E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS30005 688b839d9c8a147793bf213ff474b412 293 PRINTS PR00069 Aldo-keto reductase signature 225 249 5.3E-8 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS30005 688b839d9c8a147793bf213ff474b412 293 Gene3D G3DSA:3.20.20.100 23 290 8.8E-55 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS30005 688b839d9c8a147793bf213ff474b412 293 SUPERFAMILY SSF51430 22 291 5.37E-57 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS13890 9c69fa333f131373376398572a6932ea 281 SUPERFAMILY SSF53474 18 273 2.77E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13890 9c69fa333f131373376398572a6932ea 281 Gene3D G3DSA:3.40.50.1820 14 191 1.4E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS13890 9c69fa333f131373376398572a6932ea 281 Pfam PF00561 alpha/beta hydrolase fold 39 155 5.7E-16 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS07265 e82d0132c03e87ee3166b3e435d49e9c 346 Gene3D G3DSA:3.40.47.10 12 172 5.1E-58 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07265 e82d0132c03e87ee3166b3e435d49e9c 346 Pfam PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal 250 339 4.7E-27 T 17-03-2017 IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, C-terminal KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS07265 e82d0132c03e87ee3166b3e435d49e9c 346 Gene3D G3DSA:3.40.47.10 173 341 9.3E-42 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS07265 e82d0132c03e87ee3166b3e435d49e9c 346 Pfam PF08545 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III 117 198 1.4E-24 T 17-03-2017 IPR013751 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS07265 e82d0132c03e87ee3166b3e435d49e9c 346 TIGRFAM TIGR00747 fabH: 3-oxoacyl-[acyl-carrier-protein] synthase III 14 339 3.0E-90 T 17-03-2017 IPR004655 3-oxoacyl-[acyl-carrier-protein] synthase 3 GO:0004315|GO:0006633 KEGG: 00061+2.3.1.180|MetaCyc: PWY-4381 SHXM_RS07265 e82d0132c03e87ee3166b3e435d49e9c 346 SUPERFAMILY SSF53901 12 340 1.27E-59 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS18070 c101c383c2490103342ef94ceae3888d 202 Hamap MF_00376 Dephospho-CoA kinase [coaE]. 1 196 27.166 T 17-03-2017 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24 SHXM_RS18070 c101c383c2490103342ef94ceae3888d 202 SUPERFAMILY SSF52540 1 191 5.52E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18070 c101c383c2490103342ef94ceae3888d 202 Pfam PF01121 Dephospho-CoA kinase 4 179 1.0E-57 T 17-03-2017 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24 SHXM_RS18070 c101c383c2490103342ef94ceae3888d 202 Gene3D G3DSA:3.40.50.300 1 196 1.2E-69 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18070 c101c383c2490103342ef94ceae3888d 202 TIGRFAM TIGR00152 TIGR00152: dephospho-CoA kinase 5 187 5.5E-52 T 17-03-2017 IPR001977 Dephospho-CoA kinase GO:0004140|GO:0005524|GO:0015937 KEGG: 00770+2.7.1.24 SHXM_RS28590 bd5440c70d47aa5aa54cf56df9fdaffb 542 SMART SM00387 254 365 5.3E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28590 bd5440c70d47aa5aa54cf56df9fdaffb 542 Gene3D G3DSA:3.30.565.10 257 365 1.3E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28590 bd5440c70d47aa5aa54cf56df9fdaffb 542 SUPERFAMILY SSF55874 240 364 1.37E-18 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28590 bd5440c70d47aa5aa54cf56df9fdaffb 542 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 257 363 8.5E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25890 6207a774a2ffc2bbf58301b596e0aa9f 310 Gene3D G3DSA:3.30.420.40 2 143 2.0E-35 T 17-03-2017 SHXM_RS25890 6207a774a2ffc2bbf58301b596e0aa9f 310 Pfam PF00480 ROK family 5 301 1.7E-59 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS25890 6207a774a2ffc2bbf58301b596e0aa9f 310 Gene3D G3DSA:3.30.420.40 144 286 3.9E-45 T 17-03-2017 SHXM_RS25890 6207a774a2ffc2bbf58301b596e0aa9f 310 SUPERFAMILY SSF53067 3 304 2.46E-55 T 17-03-2017 SHXM_RS05080 7e6cc0b30c056415ef7df50a225ae170 497 Pfam PF03929 PepSY-associated TM region 48 430 4.5E-58 T 17-03-2017 IPR005625 PepSY-associated TM protein SHXM_RS29705 748d40cd58fa29678b15630dd5f30e15 472 SMART SM00331 196 421 3.3E-29 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29705 748d40cd58fa29678b15630dd5f30e15 472 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 225 421 6.7E-45 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS29705 748d40cd58fa29678b15630dd5f30e15 472 SUPERFAMILY SSF81606 212 420 1.44E-8 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50760 820ee9655abb837843585e0874370686 531 Pfam PF01610 Transposase 161 301 1.7E-14 T 17-03-2017 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SHXM_RS50760 820ee9655abb837843585e0874370686 531 Pfam PF01610 Transposase 409 527 1.0E-6 T 17-03-2017 IPR002560 Transposase IS204/IS1001/IS1096/IS1165, DDE domain SHXM_RS50760 820ee9655abb837843585e0874370686 531 Pfam PF14690 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 42 85 7.4E-7 T 17-03-2017 IPR029261 Transposase IS204/IS1001/IS1096/IS1165, zinc-finger SHXM_RS06835 ec8c8370ff22e01f0dcaae86cf205fed 213 Pfam PF13529 Peptidase_C39 like family 12 177 2.2E-9 T 17-03-2017 SHXM_RS15725 09f9fa237c34ade3d71b403c0f5ede8d 665 SUPERFAMILY SSF52540 67 237 7.91E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49600 913398a710500ae766905092a2e3e121 514 PIRSF PIRSF006060 5 488 3.7E-60 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS49600 913398a710500ae766905092a2e3e121 514 Pfam PF13520 Amino acid permease 29 447 8.7E-41 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS02885 394debb20088e92ff709afacf3d6a2b2 364 Pfam PF06224 Winged helix DNA-binding domain 31 350 5.7E-70 T 17-03-2017 IPR009351 Protein of unknown function DUF1006 SHXM_RS01115 fc26551ff9a552053a6d455f0401ec9d 118 Pfam PF13358 DDE superfamily endonuclease 2 74 7.2E-18 T 17-03-2017 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 Pfam PF00067 Cytochrome P450 190 380 2.9E-20 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 160 175 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 97 108 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 143 159 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 302 329 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 360 371 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 330 345 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 351 360 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 203 225 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 PRINTS PR00359 B-class P450 signature 285 296 3.2E-57 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 353 362 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 SUPERFAMILY SSF48264 13 407 6.29E-95 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS29280 d0b30ecb5b343ab50e6d23614920468a 408 Gene3D G3DSA:1.10.630.10 10 408 5.6E-127 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS39820 eba108c15b8b19e38dc0718b8ca87624 329 Pfam PF00248 Aldo/keto reductase family 16 311 2.0E-73 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS39820 eba108c15b8b19e38dc0718b8ca87624 329 SUPERFAMILY SSF51430 1 312 2.36E-95 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS39820 eba108c15b8b19e38dc0718b8ca87624 329 Gene3D G3DSA:3.20.20.100 1 314 9.3E-107 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS42510 8e3d1202e18a8a6da81ba7a8f2f65433 271 Pfam PF01061 ABC-2 type transporter 27 232 7.1E-19 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS42510 8e3d1202e18a8a6da81ba7a8f2f65433 271 PIRSF PIRSF006648 1 266 7.2E-16 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS28085 68537745f922c072980e6c4a2cbc4af7 361 Pfam PF13614 AAA domain 80 256 9.6E-57 T 17-03-2017 IPR025669 AAA domain SHXM_RS28085 68537745f922c072980e6c4a2cbc4af7 361 Gene3D G3DSA:3.40.50.300 82 329 4.5E-72 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS28085 68537745f922c072980e6c4a2cbc4af7 361 SUPERFAMILY SSF52540 80 329 3.2E-64 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS10690 c80c77c1c6179d00fdb5e9a8268e5269 127 Pfam PF01796 DUF35 OB-fold domain, acyl-CoA-associated 43 109 2.7E-17 T 17-03-2017 IPR002878 Domain of unknown function DUF35, OB-fold, C-terminal SHXM_RS10690 c80c77c1c6179d00fdb5e9a8268e5269 127 SUPERFAMILY SSF50249 9 109 1.11E-20 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS18350 eaf10e1a6d4489d089ae65ab58be47e5 210 Pfam PF11716 Mycothiol maleylpyruvate isomerase N-terminal domain 12 87 2.4E-7 T 17-03-2017 IPR024344 Mycothiol-dependent maleylpyruvate isomerase, metal-binding domain GO:0046872 SHXM_RS18350 eaf10e1a6d4489d089ae65ab58be47e5 210 SUPERFAMILY SSF109854 12 114 5.95E-9 T 17-03-2017 SHXM_RS18350 eaf10e1a6d4489d089ae65ab58be47e5 210 TIGRFAM TIGR03085 TIGR03085: TIGR03085 family protein 5 203 5.0E-79 T 17-03-2017 IPR017519 Conserved hypothetical protein CHP03085 SHXM_RS18350 eaf10e1a6d4489d089ae65ab58be47e5 210 TIGRFAM TIGR03083 TIGR03083: uncharacterized Actinobacterial protein TIGR03083 5 185 2.7E-38 T 17-03-2017 IPR017517 Conserved hypothetical protein CHP03083, actinobacterial-type SHXM_RS23590 689fe346b505223a0a7b12a7b8119c6c 501 SUPERFAMILY SSF103473 50 240 1.31E-33 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23590 689fe346b505223a0a7b12a7b8119c6c 501 SUPERFAMILY SSF103473 295 497 1.31E-33 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS23590 689fe346b505223a0a7b12a7b8119c6c 501 Gene3D G3DSA:1.20.1250.20 62 232 1.2E-19 T 17-03-2017 SHXM_RS23590 689fe346b505223a0a7b12a7b8119c6c 501 Gene3D G3DSA:1.20.1250.20 305 496 3.2E-5 T 17-03-2017 SHXM_RS23590 689fe346b505223a0a7b12a7b8119c6c 501 Pfam PF07690 Major Facilitator Superfamily 65 351 8.3E-22 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS15030 61038fcc94761a1161ac42c6b1e01605 141 SUPERFAMILY SSF51735 18 108 6.96E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15030 61038fcc94761a1161ac42c6b1e01605 141 Gene3D G3DSA:3.40.50.720 18 113 4.0E-16 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15030 61038fcc94761a1161ac42c6b1e01605 141 Pfam PF00107 Zinc-binding dehydrogenase 23 104 1.2E-11 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS13160 783fb0f1713ea70caf8bbfdcc361d2c6 244 Pfam PF07179 SseB protein N-terminal domain 22 143 6.0E-31 T 17-03-2017 IPR009839 SseB protein N-terminal domain SHXM_RS03025 49a98c3e6546ef830718adae66417845 140 Gene3D G3DSA:1.10.8.60 69 133 2.5E-18 T 17-03-2017 SHXM_RS03025 49a98c3e6546ef830718adae66417845 140 SMART SM01086 45 128 2.5E-5 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS03025 49a98c3e6546ef830718adae66417845 140 Pfam PF10431 C-terminal, D2-small domain, of ClpB protein 70 119 6.0E-14 T 17-03-2017 IPR019489 Clp ATPase, C-terminal SHXM_RS22190 8ff17f6492f89892879e0203dc499d87 166 Pfam PF03703 Bacterial PH domain 76 154 1.8E-14 T 17-03-2017 IPR005182 Domain of unknown function DUF304 SHXM_RS18645 5ae67b11ecc375cf804e41dc56aa507f 281 Pfam PF00005 ABC transporter 35 191 8.0E-9 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS18645 5ae67b11ecc375cf804e41dc56aa507f 281 SUPERFAMILY SSF52540 13 223 1.17E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18645 5ae67b11ecc375cf804e41dc56aa507f 281 Gene3D G3DSA:3.40.50.300 7 221 5.3E-23 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS13055 dab521d7e82ea6f92e5305721466da56 410 Pfam PF02638 Glycosyl hydrolase-like 10 38 352 1.0E-82 T 17-03-2017 IPR003790 Glycosyl hydrolase-like 10 SHXM_RS13055 dab521d7e82ea6f92e5305721466da56 410 SUPERFAMILY SSF51445 37 337 3.41E-18 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS49210 0233c4bb029e40ca65fdb2af862937d0 188 Pfam PF13358 DDE superfamily endonuclease 2 144 5.0E-23 T 17-03-2017 SHXM_RS43825 87b5ef5a562c66d848d480436004a4e6 149 SUPERFAMILY SSF50249 11 125 2.23E-14 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS43825 87b5ef5a562c66d848d480436004a4e6 149 Pfam PF12172 Rubredoxin-like zinc ribbon domain (DUF35_N) 19 52 1.0E-7 T 17-03-2017 IPR022002 Domain of unknown function DUF35, rubredoxin-like zinc ribbon domain, N-terminal SHXM_RS36140 d548145552a0c5edc53e4c287b36e920 332 SUPERFAMILY SSF51430 3 324 3.14E-86 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS36140 d548145552a0c5edc53e4c287b36e920 332 Pfam PF00248 Aldo/keto reductase family 16 324 4.1E-61 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS36140 d548145552a0c5edc53e4c287b36e920 332 Gene3D G3DSA:3.20.20.100 2 324 1.5E-110 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 9 237 2.5E-62 T 17-03-2017 SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 149 168 4.2E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 75 86 4.2E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 129 137 4.2E-9 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 75 86 7.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 123 139 7.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 169 186 7.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 4 21 7.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 149 168 7.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 202 222 7.4E-40 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 Pfam PF00006 ATP synthase alpha/beta family, nucleotide-binding domain 10 77 8.5E-5 T 17-03-2017 IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain GO:0005524 KEGG: 00190+3.6.3.14|KEGG: 00195+3.6.3.14|MetaCyc: PWY-7219 SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 SUPERFAMILY SSF51735 3 239 3.71E-76 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS31860 29d078042ad13e72f748e5eaee7dc96c 247 Gene3D G3DSA:3.40.50.720 3 238 1.1E-77 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS00605 f375045446cca0cf65a29467722b3b76 263 SUPERFAMILY SSF56281 9 251 8.3E-16 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS00605 f375045446cca0cf65a29467722b3b76 263 Pfam PF12706 Beta-lactamase superfamily domain 27 229 3.5E-14 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS00605 f375045446cca0cf65a29467722b3b76 263 Gene3D G3DSA:3.60.15.10 3 249 5.9E-38 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS30940 0a1adf41f8dd560dda4631a75218a400 321 Pfam PF00146 NADH dehydrogenase 11 313 7.8E-99 T 17-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30940 0a1adf41f8dd560dda4631a75218a400 321 Hamap MF_01350 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic [ndhA]. 3 320 21.948 T 17-03-2017 IPR001694 NADH:ubiquinone oxidoreductase, subunit 1/F420H2 oxidoreductase subunit H GO:0016020|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS43185 04424a1bea06b73c63c5e4325607db9a 304 Gene3D G3DSA:1.10.3720.10 77 295 1.1E-54 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43185 04424a1bea06b73c63c5e4325607db9a 304 SUPERFAMILY SSF161098 67 289 1.44E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS43185 04424a1bea06b73c63c5e4325607db9a 304 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 297 3.3E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS19275 00bacce3f189b472d09e4ecbbf821f42 426 SUPERFAMILY SSF53850 41 413 4.35E-89 T 17-03-2017 SHXM_RS19275 00bacce3f189b472d09e4ecbbf821f42 426 Gene3D G3DSA:3.40.190.10 171 357 5.8E-53 T 17-03-2017 SHXM_RS19275 00bacce3f189b472d09e4ecbbf821f42 426 Gene3D G3DSA:3.40.190.10 40 170 2.2E-24 T 17-03-2017 SHXM_RS19275 00bacce3f189b472d09e4ecbbf821f42 426 Pfam PF13416 Bacterial extracellular solute-binding protein 63 366 3.6E-53 T 17-03-2017 SHXM_RS34260 a49f996444d07bd668ad8f9014d530e6 502 Pfam PF08386 TAP-like protein 397 501 9.2E-32 T 17-03-2017 IPR013595 Peptidase S33 tripeptidyl aminopeptidase-like, C-terminal SHXM_RS34260 a49f996444d07bd668ad8f9014d530e6 502 SUPERFAMILY SSF53474 89 145 4.01E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34260 a49f996444d07bd668ad8f9014d530e6 502 SUPERFAMILY SSF53474 188 463 4.01E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34260 a49f996444d07bd668ad8f9014d530e6 502 Gene3D G3DSA:3.40.50.1820 63 147 9.8E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34260 a49f996444d07bd668ad8f9014d530e6 502 Gene3D G3DSA:3.40.50.1820 191 318 9.8E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34260 a49f996444d07bd668ad8f9014d530e6 502 Gene3D G3DSA:3.40.50.1820 368 489 9.8E-53 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16420 e9e582fffc247170095a96205535ddb0 353 TIGRFAM TIGR00216 ispH_lytB: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 19 297 2.8E-90 T 17-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 SHXM_RS16420 e9e582fffc247170095a96205535ddb0 353 Pfam PF02401 LytB protein 19 295 1.2E-84 T 17-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 SHXM_RS16420 e9e582fffc247170095a96205535ddb0 353 Hamap MF_00191 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [ispH]. 17 299 35.669 T 17-03-2017 IPR003451 4-hydroxy-3-methylbut-2-enyl diphosphate reductase GO:0019288|GO:0046872|GO:0050992|GO:0051745 SHXM_RS26925 d9e71ff47d400c2892bc31f6ea832a5a 381 Gene3D G3DSA:3.40.50.300 151 364 6.9E-51 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26925 d9e71ff47d400c2892bc31f6ea832a5a 381 SUPERFAMILY SSF52540 37 348 1.25E-50 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26925 d9e71ff47d400c2892bc31f6ea832a5a 381 Gene3D G3DSA:3.30.450.90 49 144 8.1E-27 T 17-03-2017 SHXM_RS26925 d9e71ff47d400c2892bc31f6ea832a5a 381 Pfam PF00437 Type II/IV secretion system protein 52 327 2.1E-79 T 17-03-2017 IPR001482 Type II secretion system protein E GO:0005524|GO:0006810 SHXM_RS26925 d9e71ff47d400c2892bc31f6ea832a5a 381 TIGRFAM TIGR03819 heli_sec_ATPase: helicase/secretion neighborhood ATPase 2 338 2.3E-156 T 17-03-2017 IPR022399 Helicase/secretion neighbourhood ATPase SHXM_RS16160 b37d7bbabe0c897377b9c2aebcfd3eae 553 PIRSF PIRSF001294 4 553 9.2E-213 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS16160 b37d7bbabe0c897377b9c2aebcfd3eae 553 TIGRFAM TIGR00680 kdpA: K+-transporting ATPase, A subunit 6 552 1.7E-199 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS16160 b37d7bbabe0c897377b9c2aebcfd3eae 553 Pfam PF03814 Potassium-transporting ATPase A subunit 14 552 2.1E-222 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS16160 b37d7bbabe0c897377b9c2aebcfd3eae 553 Hamap MF_00275 Potassium-transporting ATPase potassium-binding subunit [kdpA]. 4 553 31.999 T 17-03-2017 IPR004623 Potassium-transporting ATPase A chain GO:0005886|GO:0006813|GO:0008556 SHXM_RS08105 da413c4ad58c2301a56f1a392b534472 647 Pfam PF10022 Uncharacterized protein conserved in bacteria (DUF2264) 22 371 1.0E-102 T 17-03-2017 IPR016624 Uncharacterised conserved protein UCP014753 SHXM_RS08105 da413c4ad58c2301a56f1a392b534472 647 PIRSF PIRSF014753 4 616 6.1E-126 T 17-03-2017 IPR016624 Uncharacterised conserved protein UCP014753 SHXM_RS45550 d2041438e0a89525f7bd2280aab216eb 322 Gene3D G3DSA:1.10.3720.10 93 294 2.7E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45550 d2041438e0a89525f7bd2280aab216eb 322 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 117 291 1.2E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45550 d2041438e0a89525f7bd2280aab216eb 322 SUPERFAMILY SSF161098 94 281 9.68E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13780 2da37c55565348bb0b7108e1c3141140 37 Gene3D G3DSA:1.10.357.10 1 30 7.5E-4 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS42905 840fc20e55a3b8d4303a263419e9de68 214 Pfam PF01810 LysE type translocator 16 209 8.9E-30 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS42905 840fc20e55a3b8d4303a263419e9de68 214 PIRSF PIRSF006324 2 212 1.7E-54 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS16940 3b68944ee99e413bfc210fcd7cbe801d 143 Pfam PF04472 Protein of unknown function (DUF552) 57 128 5.4E-24 T 17-03-2017 IPR007561 Cell division protein SepF/SepF-related GO:0090529 SHXM_RS16940 3b68944ee99e413bfc210fcd7cbe801d 143 Hamap MF_01197 Cell division protein SepF [sepF]. 1 136 18.943 T 17-03-2017 IPR023052 Cell division protein SepF GO:0090529 SHXM_RS24725 4ff1da86388bc7cc4cced2e884489880 145 Gene3D G3DSA:3.10.490.10 1 145 3.1E-46 T 17-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like SHXM_RS24725 4ff1da86388bc7cc4cced2e884489880 145 SUPERFAMILY SSF110857 1 119 4.58E-14 T 17-03-2017 IPR013024 Butirosin biosynthesis, BtrG-like SHXM_RS24725 4ff1da86388bc7cc4cced2e884489880 145 Pfam PF13772 AIG2-like family 59 140 2.6E-20 T 17-03-2017 SHXM_RS30680 1b1ceb76b2c5d72d424234e524af41a5 338 Gene3D G3DSA:3.40.50.1820 59 335 3.4E-73 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30680 1b1ceb76b2c5d72d424234e524af41a5 338 Pfam PF00756 Putative esterase 70 331 4.2E-39 T 17-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 SHXM_RS30680 1b1ceb76b2c5d72d424234e524af41a5 338 SUPERFAMILY SSF53474 62 333 2.68E-42 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS17735 b8c239a3a25223483fbab0927ee1d4d6 157 PRINTS PR01398 Isochorismatase signature 58 80 9.2E-5 T 17-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 SHXM_RS17735 b8c239a3a25223483fbab0927ee1d4d6 157 PRINTS PR01398 Isochorismatase signature 132 149 9.2E-5 T 17-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 SHXM_RS17735 b8c239a3a25223483fbab0927ee1d4d6 157 PRINTS PR01398 Isochorismatase signature 114 132 9.2E-5 T 17-03-2017 IPR016291 Isochorismatase GO:0008908 MetaCyc: PWY-5901 SHXM_RS17735 b8c239a3a25223483fbab0927ee1d4d6 157 Pfam PF00857 Isochorismatase family 31 151 5.7E-29 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS17735 b8c239a3a25223483fbab0927ee1d4d6 157 SUPERFAMILY SSF52499 33 154 5.76E-36 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS17735 b8c239a3a25223483fbab0927ee1d4d6 157 Gene3D G3DSA:3.40.50.850 38 155 8.3E-38 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS17585 670c43584fd917e58fc3b209eeb90440 134 Pfam PF06339 Ectoine synthase 2 127 4.6E-56 T 17-03-2017 IPR010462 Ectoine synthase GO:0019491|GO:0033990 KEGG: 00260+4.2.1.108|KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS17585 670c43584fd917e58fc3b209eeb90440 134 ProDom PD080544 SYNTHASE 4.2.1.- LYASE L-ECTOINE DEHYDRATASE N-ACETYLDIAMINOBUTYRATE ECTOINE ENZYME SYNTHASE:ECTOINE ECTC 1 119 4.0E-61 T 17-03-2017 IPR010462 Ectoine synthase GO:0019491|GO:0033990 KEGG: 00260+4.2.1.108|KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS17585 670c43584fd917e58fc3b209eeb90440 134 Gene3D G3DSA:2.60.120.10 24 113 8.8E-12 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS17585 670c43584fd917e58fc3b209eeb90440 134 SUPERFAMILY SSF51182 3 128 8.62E-20 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS17585 670c43584fd917e58fc3b209eeb90440 134 Hamap MF_01255 L-ectoine synthase [ectC]. 1 129 38.77 T 17-03-2017 IPR010462 Ectoine synthase GO:0019491|GO:0033990 KEGG: 00260+4.2.1.108|KEGG: 00400+4.2.1.10|MetaCyc: PWY-6163|MetaCyc: PWY-6416|MetaCyc: PWY-6707 SHXM_RS43685 bd3f6046b2a2321ed6cbad0726f94bd8 88 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 77 18.066 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS43685 bd3f6046b2a2321ed6cbad0726f94bd8 88 Pfam PF02467 Transcription factor WhiB 3 72 6.9E-25 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS08970 1304874a08bfa4ba6519cfae831f2d22 110 Pfam PF13443 Cro/C1-type HTH DNA-binding domain 4 72 1.5E-19 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS17910 e0f80ea04a3e96a537d90c0d737c75bb 75 PRINTS PR01651 Protein-export SecG membrane protein signature 36 52 5.9E-7 T 17-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SHXM_RS17910 e0f80ea04a3e96a537d90c0d737c75bb 75 PRINTS PR01651 Protein-export SecG membrane protein signature 52 74 5.9E-7 T 17-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SHXM_RS17910 e0f80ea04a3e96a537d90c0d737c75bb 75 PRINTS PR01651 Protein-export SecG membrane protein signature 21 35 5.9E-7 T 17-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SHXM_RS17910 e0f80ea04a3e96a537d90c0d737c75bb 75 PRINTS PR01651 Protein-export SecG membrane protein signature 1 21 5.9E-7 T 17-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SHXM_RS17910 e0f80ea04a3e96a537d90c0d737c75bb 75 Pfam PF03840 Preprotein translocase SecG subunit 3 71 3.4E-20 T 17-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SHXM_RS17910 e0f80ea04a3e96a537d90c0d737c75bb 75 TIGRFAM TIGR00810 secG: preprotein translocase, SecG subunit 3 71 2.9E-21 T 17-03-2017 IPR004692 Preprotein translocase SecG subunit GO:0009306|GO:0015450|GO:0016021 SHXM_RS16880 89ea5ba987425dc510e6926ce07a2c48 154 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 10 88 4.8E-15 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS16880 89ea5ba987425dc510e6926ce07a2c48 154 SUPERFAMILY SSF50475 10 143 6.17E-32 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS16880 89ea5ba987425dc510e6926ce07a2c48 154 Gene3D G3DSA:2.30.110.10 6 145 4.9E-26 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS16880 89ea5ba987425dc510e6926ce07a2c48 154 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 11 140 4.1E-39 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS30865 3f136ab3fafa22e7d045aa851b567014 412 SUPERFAMILY SSF89392 132 298 6.28E-12 T 17-03-2017 IPR029046 Lipoprotein localisation LolA/LolB/LppX SHXM_RS30865 3f136ab3fafa22e7d045aa851b567014 412 Gene3D G3DSA:2.50.20.10 134 299 4.7E-15 T 17-03-2017 SHXM_RS14625 87111bbdb6d3f392a4c9e52ebcb0c375 129 Pfam PF11387 Protein of unknown function (DUF2795) 75 119 1.3E-11 T 17-03-2017 IPR021527 Protein of unknown function DUF2795 SHXM_RS36730 bb2979fbd89984801985a4c270519334 453 SUPERFAMILY SSF53383 9 448 6.19E-126 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS36730 bb2979fbd89984801985a4c270519334 453 Gene3D G3DSA:3.40.640.10 65 338 4.1E-83 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS36730 bb2979fbd89984801985a4c270519334 453 Gene3D G3DSA:3.90.1150.10 3 63 7.5E-36 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS36730 bb2979fbd89984801985a4c270519334 453 Gene3D G3DSA:3.90.1150.10 340 448 7.5E-36 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS36730 bb2979fbd89984801985a4c270519334 453 ProSitePatterns PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. 251 288 - T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS36730 bb2979fbd89984801985a4c270519334 453 Pfam PF00202 Aminotransferase class-III 29 446 7.8E-100 T 17-03-2017 IPR005814 Aminotransferase class-III GO:0008483|GO:0030170 SHXM_RS49475 c4c1a0c637b493c4358d9d796b24cbf0 275 SMART SM00382 59 253 1.1E-6 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS49475 c4c1a0c637b493c4358d9d796b24cbf0 275 SUPERFAMILY SSF52540 27 268 2.79E-53 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49475 c4c1a0c637b493c4358d9d796b24cbf0 275 Pfam PF00005 ABC transporter 50 204 1.4E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS49475 c4c1a0c637b493c4358d9d796b24cbf0 275 Gene3D G3DSA:3.40.50.300 26 270 8.6E-59 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49475 c4c1a0c637b493c4358d9d796b24cbf0 275 ProSitePatterns PS00211 ABC transporters family signature. 177 191 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS45420 6450140b157fd383c280b58d6e03cedf 476 Pfam PF12275 Protein of unknown function (DUF3616) 291 406 0.0026 T 17-03-2017 IPR022060 Protein of unknown function DUF3616 SHXM_RS33430 b39ae06b417e4d6662ce11e5cccf3a54 336 Gene3D G3DSA:3.20.20.80 48 327 7.4E-61 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS33430 b39ae06b417e4d6662ce11e5cccf3a54 336 Pfam PF00704 Glycosyl hydrolases family 18 51 325 3.1E-27 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS33430 b39ae06b417e4d6662ce11e5cccf3a54 336 SMART SM00636 49 318 5.4E-7 T 17-03-2017 IPR011583 Chitinase II GO:0004568|GO:0006032 SHXM_RS33430 b39ae06b417e4d6662ce11e5cccf3a54 336 SUPERFAMILY SSF51445 47 325 1.2E-52 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS33430 b39ae06b417e4d6662ce11e5cccf3a54 336 ProSitePatterns PS01095 Chitinases family 18 active site. 156 164 - T 17-03-2017 IPR001579 Glycoside hydrolase, chitinase active site GO:0004553|GO:0005975 KEGG: 00520+3.2.1.14|MetaCyc: PWY-6902 SHXM_RS15665 a12de035857855fc29ad8936164144a4 140 Gene3D G3DSA:3.40.50.1010 3 124 3.0E-7 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS15665 a12de035857855fc29ad8936164144a4 140 Hamap MF_00265 tRNA(fMet)-specific endonuclease VapC [vapC]. 5 129 10.653 T 17-03-2017 IPR022907 VapC family GO:0004540 SHXM_RS15665 a12de035857855fc29ad8936164144a4 140 SUPERFAMILY SSF88723 5 122 1.4E-12 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS15665 a12de035857855fc29ad8936164144a4 140 Pfam PF01850 PIN domain 5 124 5.2E-9 T 17-03-2017 IPR002716 PIN domain SHXM_RS05135 9af56ce7fd0f12b7bf24b36c77b82fbd 553 Gene3D G3DSA:2.120.10.30 157 298 1.4E-33 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS05135 9af56ce7fd0f12b7bf24b36c77b82fbd 553 Gene3D G3DSA:2.120.10.30 21 120 1.4E-33 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS05135 9af56ce7fd0f12b7bf24b36c77b82fbd 553 Gene3D G3DSA:2.120.10.30 348 548 3.0E-22 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS05135 9af56ce7fd0f12b7bf24b36c77b82fbd 553 SUPERFAMILY SSF63829 344 549 3.11E-26 T 17-03-2017 SHXM_RS05135 9af56ce7fd0f12b7bf24b36c77b82fbd 553 SUPERFAMILY SSF101898 17 213 4.18E-26 T 17-03-2017 SHXM_RS23995 a1745d44f49bee7294bc26e9569f44ef 594 Pfam PF11380 Stealth protein CR2, conserved region 2 305 410 3.2E-46 T 17-03-2017 IPR021520 Stealth protein CR2, conserved region 2 GO:0016772 SHXM_RS23995 a1745d44f49bee7294bc26e9569f44ef 594 Pfam PF17103 Stealth protein CR4, conserved region 4 531 584 1.1E-12 T 17-03-2017 IPR031356 Stealth protein CR4, conserved region 4 SHXM_RS23995 a1745d44f49bee7294bc26e9569f44ef 594 Pfam PF17102 Stealth protein CR3, conserved region 3 455 502 5.7E-18 T 17-03-2017 IPR031357 Stealth protein CR3, conserved region 3 SHXM_RS23995 a1745d44f49bee7294bc26e9569f44ef 594 Pfam PF17101 Stealth protein CR1, conserved region 1 268 291 3.7E-14 T 17-03-2017 IPR031358 Stealth protein CR1, conserved region 1 SHXM_RS29205 214acc8c1bb3cd77837d6733dab9c4fc 126 SUPERFAMILY SSF54593 17 107 3.52E-9 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS29205 214acc8c1bb3cd77837d6733dab9c4fc 126 Gene3D G3DSA:3.10.180.10 17 75 9.6E-5 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS29205 214acc8c1bb3cd77837d6733dab9c4fc 126 Gene3D G3DSA:3.10.180.10 76 115 1.1E-4 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 388 399 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 117 128 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 379 388 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 358 373 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 163 179 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 226 248 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 330 357 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 312 323 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 PRINTS PR00359 B-class P450 signature 180 195 2.0E-52 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 SUPERFAMILY SSF48264 33 439 3.01E-99 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 Gene3D G3DSA:1.10.630.10 32 440 1.1E-131 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS24565 1c1c5d21f7a84dbbee31e778e49440e5 444 Pfam PF00067 Cytochrome P450 210 408 4.1E-24 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS29625 0ffbf7744e26bfa305e40e56eb617642 59 Pfam PF12728 Helix-turn-helix domain 5 54 1.5E-14 T 17-03-2017 SHXM_RS29625 0ffbf7744e26bfa305e40e56eb617642 59 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 5 51 8.5E-12 T 17-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 SHXM_RS21130 19514d488dc7eca1a9bc677dd80421bf 132 Gene3D G3DSA:1.10.3300.10 6 122 2.9E-20 T 17-03-2017 IPR023286 ABATE domain SHXM_RS21130 19514d488dc7eca1a9bc677dd80421bf 132 SUPERFAMILY SSF160904 21 120 8.11E-20 T 17-03-2017 SHXM_RS21130 19514d488dc7eca1a9bc677dd80421bf 132 Pfam PF11706 CGNR zinc finger 76 121 2.3E-16 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS17205 5bc60bcf8fad382e3632a780adeb9594 260 Pfam PF07070 SpoOM protein 3 216 8.3E-80 T 17-03-2017 IPR009776 Sporulation stage 0, protein M SHXM_RS25365 44312ab29bfe2dcaaec7c883fca07c41 341 SUPERFAMILY SSF54001 223 333 8.34E-41 T 17-03-2017 SHXM_RS25365 44312ab29bfe2dcaaec7c883fca07c41 341 Pfam PF00877 NlpC/P60 family 241 329 1.2E-24 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS25365 44312ab29bfe2dcaaec7c883fca07c41 341 Gene3D G3DSA:3.90.1720.10 224 330 1.9E-43 T 17-03-2017 IPR000064 Endopeptidase, NLPC/P60 domain SHXM_RS35270 7090a6516038eec2901594522302c99b 149 Pfam PF10739 Protein of unknown function (DUF2550) 12 143 3.2E-46 T 17-03-2017 IPR019675 Protein of unknown function DUF2550 SHXM_RS38095 003f7076780ca1a47c51adb4ce8743c6 105 Gene3D G3DSA:3.40.50.720 2 79 1.7E-21 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38095 003f7076780ca1a47c51adb4ce8743c6 105 SUPERFAMILY SSF51735 2 96 2.13E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS14140 45d170794ee4d5cad7ce1e253a0abd08 349 Pfam PF01261 Xylose isomerase-like TIM barrel 86 299 8.7E-24 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14140 45d170794ee4d5cad7ce1e253a0abd08 349 Gene3D G3DSA:3.20.20.150 62 344 2.7E-57 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS14140 45d170794ee4d5cad7ce1e253a0abd08 349 SUPERFAMILY SSF51658 69 343 1.46E-34 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS04425 bacf3c15e5e89ad13c87369927633c45 513 PIRSF PIRSF002744 1 485 5.0E-102 T 17-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 SHXM_RS04425 bacf3c15e5e89ad13c87369927633c45 513 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 18 458 1.7E-41 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS23015 1fe033cd137c032673cc6a0badeca3a1 72 Pfam PF10041 Uncharacterized conserved protein (DUF2277) 1 68 4.1E-27 T 17-03-2017 IPR018735 Protein of unknown function DUF2277 SHXM_RS23340 07d94a08c69ba02d7775cbcb610ee464 272 Pfam PF06182 ABC-2 family transporter protein 39 271 6.9E-60 T 17-03-2017 IPR010390 Protein of unknown function DUF990 SHXM_RS21780 f86c9a60d4d48aa94644b35c8715309b 337 SUPERFAMILY SSF53850 71 289 1.16E-5 T 17-03-2017 SHXM_RS21780 f86c9a60d4d48aa94644b35c8715309b 337 Pfam PF03401 Tripartite tricarboxylate transporter family receptor 70 331 2.1E-27 T 17-03-2017 IPR005064 Bordetella uptake gene GO:0030288 SHXM_RS21780 f86c9a60d4d48aa94644b35c8715309b 337 PIRSF PIRSF017082 1 337 2.7E-72 T 17-03-2017 IPR005064 Bordetella uptake gene GO:0030288 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 Gene3D G3DSA:3.20.20.140 77 361 1.0E-81 T 17-03-2017 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 SUPERFAMILY SSF51556 75 376 1.52E-85 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 Pfam PF01979 Amidohydrolase family 71 415 1.4E-42 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 Gene3D G3DSA:2.30.40.10 385 419 2.7E-21 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 Gene3D G3DSA:2.30.40.10 14 76 2.7E-21 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 Gene3D G3DSA:2.30.40.10 362 384 2.3E-4 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 SUPERFAMILY SSF51338 13 75 1.82E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS45855 a352c412834bd8abb367b1ac4c8f07b9 433 SUPERFAMILY SSF51338 376 418 1.82E-14 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS25135 11c87d4cefb6e91f194df48db5865375 544 SUPERFAMILY SSF56601 147 158 1.71E-42 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS25135 11c87d4cefb6e91f194df48db5865375 544 SUPERFAMILY SSF56601 198 460 1.71E-42 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS25135 11c87d4cefb6e91f194df48db5865375 544 Gene3D G3DSA:3.40.710.10 204 460 3.0E-66 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS25135 11c87d4cefb6e91f194df48db5865375 544 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 204 439 2.3E-33 T 17-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 SHXM_RS25135 11c87d4cefb6e91f194df48db5865375 544 Pfam PF17199 Protein of unknown function (DUF5136) 46 75 1.4E-20 T 17-03-2017 SHXM_RS38245 5aa94fa4257fbec5b903aecf03f039b2 239 Pfam PF11452 Protein of unknown function (DUF3000) 23 220 4.6E-71 T 17-03-2017 IPR021555 Protein of unknown function DUF3000 SHXM_RS24440 3a453cf1ae60bf7b6cae84450bc0ea0c 312 SUPERFAMILY SSF53850 46 310 4.89E-53 T 17-03-2017 SHXM_RS24440 3a453cf1ae60bf7b6cae84450bc0ea0c 312 Gene3D G3DSA:3.40.190.120 151 249 5.3E-27 T 17-03-2017 SHXM_RS24440 3a453cf1ae60bf7b6cae84450bc0ea0c 312 Gene3D G3DSA:3.40.190.10 45 150 5.6E-41 T 17-03-2017 SHXM_RS24440 3a453cf1ae60bf7b6cae84450bc0ea0c 312 Gene3D G3DSA:3.40.190.10 260 310 5.6E-41 T 17-03-2017 SHXM_RS24440 3a453cf1ae60bf7b6cae84450bc0ea0c 312 Pfam PF04069 Substrate binding domain of ABC-type glycine betaine transport system 47 305 2.7E-51 T 17-03-2017 IPR007210 ABC-type glycine betaine transport system, substrate-binding domain GO:0005215|GO:0006810 SHXM_RS12915 4a7e731a164b72925d9420c001f4eb4c 625 Pfam PF06259 Alpha/beta hydrolase 377 557 1.5E-31 T 17-03-2017 IPR010427 Protein of unknown function DUF1023 SHXM_RS35970 bef7312a9f5742426f0e545119abb48d 260 Pfam PF07179 SseB protein N-terminal domain 24 133 5.4E-12 T 17-03-2017 IPR009839 SseB protein N-terminal domain SHXM_RS35970 bef7312a9f5742426f0e545119abb48d 260 Pfam PF14581 SseB protein C-terminal domain 147 258 3.4E-25 T 17-03-2017 IPR027945 SseB protein, C-terminal SHXM_RS16670 eb0a529d897f5416e3b271c23819ff5e 446 SUPERFAMILY SSF55874 281 405 9.04E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS16670 eb0a529d897f5416e3b271c23819ff5e 446 Gene3D G3DSA:3.30.565.10 279 407 1.0E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS16670 eb0a529d897f5416e3b271c23819ff5e 446 Pfam PF07730 Histidine kinase 190 255 4.7E-17 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS16670 eb0a529d897f5416e3b271c23819ff5e 446 Pfam PF13581 Histidine kinase-like ATPase domain 307 374 2.2E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS32640 25f16abbd8bf8fed4644befeccc84af6 295 SUPERFAMILY SSF103481 41 135 9.81E-14 T 17-03-2017 SHXM_RS32640 25f16abbd8bf8fed4644befeccc84af6 295 SUPERFAMILY SSF103481 214 293 6.28E-7 T 17-03-2017 SHXM_RS32640 25f16abbd8bf8fed4644befeccc84af6 295 Pfam PF00892 EamA-like transporter family 159 292 5.7E-7 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS32640 25f16abbd8bf8fed4644befeccc84af6 295 Pfam PF00892 EamA-like transporter family 8 130 5.4E-8 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS38870 a515bc5f832e5260fd9365b653d1b448 383 Pfam PF02625 XdhC and CoxI family 11 78 7.5E-22 T 17-03-2017 IPR003777 XdhC- CoxI SHXM_RS38870 a515bc5f832e5260fd9365b653d1b448 383 Pfam PF02625 XdhC and CoxI family 119 183 2.2E-13 T 17-03-2017 IPR003777 XdhC- CoxI SHXM_RS38870 a515bc5f832e5260fd9365b653d1b448 383 Pfam PF13478 XdhC Rossmann domain 207 349 6.9E-39 T 17-03-2017 IPR027051 XdhC Rossmann domain SHXM_RS10235 956b8359fddf76fd8fe20551f7a3d775 341 Gene3D G3DSA:3.30.572.10 10 235 1.1E-34 T 17-03-2017 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS10235 956b8359fddf76fd8fe20551f7a3d775 341 Pfam PF00303 Thymidylate synthase 13 233 2.3E-17 T 17-03-2017 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS10235 956b8359fddf76fd8fe20551f7a3d775 341 PRINTS PR00108 Thymidylate synthase family signature 170 196 3.1E-5 T 17-03-2017 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS10235 956b8359fddf76fd8fe20551f7a3d775 341 PRINTS PR00108 Thymidylate synthase family signature 208 225 3.1E-5 T 17-03-2017 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS10235 956b8359fddf76fd8fe20551f7a3d775 341 PRINTS PR00108 Thymidylate synthase family signature 53 74 3.1E-5 T 17-03-2017 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS10235 956b8359fddf76fd8fe20551f7a3d775 341 SUPERFAMILY SSF55831 7 274 4.84E-40 T 17-03-2017 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-113510|Reactome: R-HSA-500753|Reactome: R-HSA-69205 SHXM_RS46720 d4eb36be66ba513c476563f4cb5d1bba 352 SUPERFAMILY SSF81345 16 344 3.14E-73 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS46720 d4eb36be66ba513c476563f4cb5d1bba 352 Gene3D G3DSA:1.10.3470.10 18 348 3.7E-93 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS46720 d4eb36be66ba513c476563f4cb5d1bba 352 Pfam PF01032 FecCD transport family 32 345 1.8E-82 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS28625 80ebf6c459860531b7d3fc14541b5e6c 251 SUPERFAMILY SSF47413 3 59 2.79E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28625 80ebf6c459860531b7d3fc14541b5e6c 251 Gene3D G3DSA:1.10.260.40 3 54 1.2E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28625 80ebf6c459860531b7d3fc14541b5e6c 251 SUPERFAMILY SSF56024 79 186 3.88E-5 T 17-03-2017 SHXM_RS43665 64258ad7545b2acd1d83abc9be969f58 388 Pfam PF13439 Glycosyltransferase Family 4 14 195 1.2E-24 T 17-03-2017 IPR028098 Glycosyltransferase subfamily 4-like, N-terminal domain Reactome: R-HSA-446193|Reactome: R-HSA-4549349 SHXM_RS43665 64258ad7545b2acd1d83abc9be969f58 388 Gene3D G3DSA:3.40.50.2000 186 358 6.0E-25 T 17-03-2017 SHXM_RS43665 64258ad7545b2acd1d83abc9be969f58 388 Pfam PF00534 Glycosyl transferases group 1 206 358 1.1E-23 T 17-03-2017 IPR001296 Glycosyl transferase, family 1 SHXM_RS43665 64258ad7545b2acd1d83abc9be969f58 388 SUPERFAMILY SSF53756 1 380 1.08E-74 T 17-03-2017 SHXM_RS10285 2f1726e2f1f6515dcec3ba4b19ed1269 140 Gene3D G3DSA:3.30.420.10 31 106 2.9E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10285 2f1726e2f1f6515dcec3ba4b19ed1269 140 SUPERFAMILY SSF53098 19 107 3.22E-10 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS10285 2f1726e2f1f6515dcec3ba4b19ed1269 140 Pfam PF13683 Integrase core domain 42 106 1.5E-15 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 Pfam PF07690 Major Facilitator Superfamily 35 426 4.6E-55 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 Gene3D G3DSA:1.20.1250.20 287 437 5.6E-24 T 17-03-2017 SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 Gene3D G3DSA:1.20.1250.20 496 522 5.6E-24 T 17-03-2017 SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 Gene3D G3DSA:1.20.1250.20 24 214 2.4E-35 T 17-03-2017 SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 SUPERFAMILY SSF103473 495 520 2.22E-73 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 SUPERFAMILY SSF103473 265 436 2.22E-73 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 SUPERFAMILY SSF103473 16 213 2.22E-73 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS20245 f1f344dd7d6d2ce5dd18a241776a6c28 533 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 30 518 2.8E-89 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS45515 33e51253f4a6eb46a698f591951315cc 392 Gene3D G3DSA:2.60.120.620 79 289 1.3E-14 T 17-03-2017 SHXM_RS45515 33e51253f4a6eb46a698f591951315cc 392 SUPERFAMILY SSF51197 79 360 8.51E-48 T 17-03-2017 SHXM_RS45515 33e51253f4a6eb46a698f591951315cc 392 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 68 287 7.1E-34 T 17-03-2017 IPR008775 Phytanoyl-CoA dioxygenase SHXM_RS33650 37d86da11cfbef8dad82172d3aaa3477 179 Pfam PF14030 Protein of unknown function (DUF4245) 2 174 2.6E-51 T 17-03-2017 IPR025339 Protein of unknown function DUF4245 SHXM_RS26170 c6a1d18804900929a3531515146bbea4 493 Pfam PF13520 Amino acid permease 12 424 3.6E-55 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS26170 c6a1d18804900929a3531515146bbea4 493 PIRSF PIRSF006060 1 479 3.6E-83 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS05040 11f340c9aa226a8a651d6b7d6b82df28 349 Gene3D G3DSA:3.40.50.1970 10 170 1.6E-47 T 17-03-2017 SHXM_RS05040 11f340c9aa226a8a651d6b7d6b82df28 349 SUPERFAMILY SSF56796 10 337 1.05E-87 T 17-03-2017 SHXM_RS05040 11f340c9aa226a8a651d6b7d6b82df28 349 Pfam PF01761 3-dehydroquinate synthase 67 308 3.3E-80 T 17-03-2017 IPR030960 3-dehydroquinate synthase domain KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS05040 11f340c9aa226a8a651d6b7d6b82df28 349 Gene3D G3DSA:1.20.1090.10 197 337 3.0E-39 T 17-03-2017 SHXM_RS05040 11f340c9aa226a8a651d6b7d6b82df28 349 Hamap MF_00110 3-dehydroquinate synthase [aroB]. 9 340 30.734 T 17-03-2017 IPR016037 3-dehydroquinate synthase AroB GO:0003856|GO:0005737|GO:0009073 KEGG: 00400+4.2.3.4|MetaCyc: PWY-6164 SHXM_RS35550 5f8b12b90eb9b6589bfcd20f9b33b730 297 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 285 2.4E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35550 5f8b12b90eb9b6589bfcd20f9b33b730 297 SUPERFAMILY SSF161098 27 293 5.23E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35550 5f8b12b90eb9b6589bfcd20f9b33b730 297 Gene3D G3DSA:1.10.3720.10 24 282 5.6E-52 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12735 fc30f7e4c60ebfc2ca9191d3667b4095 98 Pfam PF13453 Transcription factor zinc-finger 2 40 1.5E-17 T 17-03-2017 IPR027392 Transcription factor zinc-finger SHXM_RS49450 76a7e585a2b1284929f21e9113cf53f5 80 Pfam PF11755 Protein of unknown function (DUF3311) 21 77 1.4E-10 T 17-03-2017 IPR021741 Protein of unknown function DUF3311 SHXM_RS01175 2ded47266f940a84cab718eae71a98ae 553 SUPERFAMILY SSF53335 160 353 1.18E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01175 2ded47266f940a84cab718eae71a98ae 553 Gene3D G3DSA:3.40.50.150 164 381 4.6E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS01175 2ded47266f940a84cab718eae71a98ae 553 TIGRFAM TIGR04364 methyltran_FxLD: methyltransferase, FxLD system 159 552 2.6E-132 T 17-03-2017 IPR027573 Methyltransferase, FxLD system SHXM_RS01175 2ded47266f940a84cab718eae71a98ae 553 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 162 368 1.1E-32 T 17-03-2017 SHXM_RS12460 a0ddb868cb38f616a0ee20c7d1f426f5 300 Gene3D G3DSA:3.20.180.10 207 299 2.3E-8 T 17-03-2017 IPR019595 Domain of unknown function DUF2470 SHXM_RS12460 a0ddb868cb38f616a0ee20c7d1f426f5 300 SUPERFAMILY SSF50475 66 298 2.16E-16 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS12460 a0ddb868cb38f616a0ee20c7d1f426f5 300 Pfam PF10615 Protein of unknown function (DUF2470) 213 293 8.4E-7 T 17-03-2017 IPR019595 Domain of unknown function DUF2470 SHXM_RS00940 b6f582afa291bd1a73ec9433d79c18fb 161 ProSitePatterns PS00934 Glyoxalase I signature 1. 12 33 - T 17-03-2017 IPR018146 Glyoxalase I, conserved site GO:0004462|GO:0046872 KEGG: 00620+4.4.1.5|MetaCyc: PWY-5386|Reactome: R-HSA-70268 SHXM_RS00940 b6f582afa291bd1a73ec9433d79c18fb 161 Gene3D G3DSA:3.10.180.10 9 154 2.7E-21 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS00940 b6f582afa291bd1a73ec9433d79c18fb 161 Pfam PF00903 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 9 124 1.3E-14 T 17-03-2017 IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain SHXM_RS00940 b6f582afa291bd1a73ec9433d79c18fb 161 SUPERFAMILY SSF54593 2 154 1.26E-27 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS30415 c2e4a18a4d4ee76ae7aed5d6409485d7 78 TIGRFAM TIGR01764 excise: DNA binding domain, excisionase family 22 69 5.2E-21 T 17-03-2017 IPR010093 SinI-like, DNA-binding domain GO:0003677 SHXM_RS30415 c2e4a18a4d4ee76ae7aed5d6409485d7 78 Gene3D G3DSA:1.10.10.10 22 70 3.5E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS30415 c2e4a18a4d4ee76ae7aed5d6409485d7 78 SUPERFAMILY SSF46955 22 71 2.38E-5 T 17-03-2017 IPR009061 Putative DNA-binding domain SHXM_RS30415 c2e4a18a4d4ee76ae7aed5d6409485d7 78 Pfam PF12728 Helix-turn-helix domain 22 70 6.2E-14 T 17-03-2017 SHXM_RS37700 6ebcd2a073821d163b122e9403413491 696 Pfam PF13520 Amino acid permease 57 464 7.7E-32 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS18940 b053dc309dfb878b4418d06b39a47ed7 392 Pfam PF02445 Quinolinate synthetase A protein 51 390 9.8E-106 T 17-03-2017 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 SHXM_RS18940 b053dc309dfb878b4418d06b39a47ed7 392 SUPERFAMILY SSF142754 50 391 9.81E-93 T 17-03-2017 SHXM_RS18940 b053dc309dfb878b4418d06b39a47ed7 392 Hamap MF_00569 Quinolinate synthase A [nadA]. 41 391 56.492 T 17-03-2017 IPR023515 Quinolinate synthase A, type 3 GO:0016765 MetaCyc: PWY-5316|MetaCyc: PWY-7342 SHXM_RS18940 b053dc309dfb878b4418d06b39a47ed7 392 TIGRFAM TIGR00550 nadA: quinolinate synthetase complex, A subunit 45 391 6.5E-99 T 17-03-2017 IPR003473 Quinolinate synthetase A GO:0008987|GO:0009435|GO:0051539 MetaCyc: PWY-5316|MetaCyc: PWY-7342 SHXM_RS30015 18805e0deea27a678aace9d0fbb7f1f6 270 Pfam PF02525 Flavodoxin-like fold 4 213 3.0E-58 T 17-03-2017 IPR003680 Flavodoxin-like fold SHXM_RS30015 18805e0deea27a678aace9d0fbb7f1f6 270 Gene3D G3DSA:3.40.50.360 4 234 2.8E-72 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS30015 18805e0deea27a678aace9d0fbb7f1f6 270 SUPERFAMILY SSF52218 4 242 8.73E-71 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS46680 ef501ad861668a6bff418ebf0c508c08 294 Pfam PF01261 Xylose isomerase-like TIM barrel 21 238 4.9E-34 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS46680 ef501ad861668a6bff418ebf0c508c08 294 SUPERFAMILY SSF51658 7 274 8.38E-53 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS46680 ef501ad861668a6bff418ebf0c508c08 294 Gene3D G3DSA:3.20.20.150 2 284 1.2E-53 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS50535 f7f1faeca3d55551f1a218bbb1ad2bda 446 Gene3D G3DSA:3.20.20.30 9 304 1.7E-121 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50535 f7f1faeca3d55551f1a218bbb1ad2bda 446 Gene3D G3DSA:3.20.20.30 340 425 1.7E-121 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50535 f7f1faeca3d55551f1a218bbb1ad2bda 446 Pfam PF00296 Luciferase-like monooxygenase 14 381 5.8E-61 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS50535 f7f1faeca3d55551f1a218bbb1ad2bda 446 PIRSF PIRSF000337 1 436 4.7E-135 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS50535 f7f1faeca3d55551f1a218bbb1ad2bda 446 TIGRFAM TIGR03860 FMN_nitrolo: FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family 3 422 4.5E-151 T 17-03-2017 IPR016215 Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A GO:0004497 SHXM_RS50535 f7f1faeca3d55551f1a218bbb1ad2bda 446 SUPERFAMILY SSF51679 7 426 2.88E-112 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS46020 3592ddc3c1705ce242f4f1ab0c5b76b8 244 Pfam PF09844 Uncharacterized conserved protein (COG2071) 21 234 2.5E-67 T 17-03-2017 IPR018644 Protein of unknown function DUF2071 SHXM_RS46020 3592ddc3c1705ce242f4f1ab0c5b76b8 244 SUPERFAMILY SSF160104 13 201 9.68E-11 T 17-03-2017 SHXM_RS43870 3c9f9a39da5945aed743745a599f73fb 441 Pfam PF07690 Major Facilitator Superfamily 3 391 1.9E-13 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS43870 3c9f9a39da5945aed743745a599f73fb 441 SUPERFAMILY SSF103473 226 418 6.15E-29 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS43870 3c9f9a39da5945aed743745a599f73fb 441 SUPERFAMILY SSF103473 3 188 6.15E-29 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS43870 3c9f9a39da5945aed743745a599f73fb 441 Gene3D G3DSA:1.20.1250.20 232 417 7.8E-7 T 17-03-2017 SHXM_RS43870 3c9f9a39da5945aed743745a599f73fb 441 Gene3D G3DSA:1.20.1250.20 3 177 6.3E-15 T 17-03-2017 SHXM_RS06885 d077ee82978913871b90772171678055 116 Pfam PF05336 Domain of unknown function (DUF718) 2 105 7.5E-19 T 17-03-2017 IPR008000 Rhamnose/fucose mutarotase GO:0005737|GO:0016857 SHXM_RS06885 d077ee82978913871b90772171678055 116 SUPERFAMILY SSF54909 1 106 5.9E-22 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SUPERFAMILY SSF51126 211 574 3.69E-36 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 572 604 9700.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 523 545 670.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 485 512 430.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 397 419 1800.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 547 569 1.8 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 425 453 3000.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 365 387 420.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 SMART SM00710 311 344 3500.0 T 17-03-2017 IPR006626 Parallel beta-helix repeat SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 Gene3D G3DSA:2.160.20.10 212 590 1.9E-27 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS01520 30af0d76fc59aa9347fe2f23cb4861e0 604 Pfam PF12708 Pectate lyase superfamily protein 227 452 9.5E-14 T 17-03-2017 IPR024535 Pectate lyase superfamily protein SHXM_RS48045 511f6b33621d7afaf5be778165c363f6 307 SUPERFAMILY SSF56112 37 290 1.6E-26 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS48045 511f6b33621d7afaf5be778165c363f6 307 Pfam PF04655 Aminoglycoside/hydroxyurea antibiotic resistance kinase 42 288 1.7E-75 T 17-03-2017 IPR006748 Aminoglycoside/hydroxyurea antibiotic resistance kinase GO:0006468|GO:0016773|GO:0019748 SHXM_RS22405 a12c5e19e853416af783a53e597ff2e5 429 Gene3D G3DSA:3.40.190.10 154 323 1.2E-15 T 17-03-2017 SHXM_RS22405 a12c5e19e853416af783a53e597ff2e5 429 Pfam PF01547 Bacterial extracellular solute-binding protein 52 336 9.0E-31 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS22405 a12c5e19e853416af783a53e597ff2e5 429 Gene3D G3DSA:3.40.190.10 324 357 1.7E-24 T 17-03-2017 SHXM_RS22405 a12c5e19e853416af783a53e597ff2e5 429 Gene3D G3DSA:3.40.190.10 11 144 1.7E-24 T 17-03-2017 SHXM_RS22405 a12c5e19e853416af783a53e597ff2e5 429 SUPERFAMILY SSF53850 35 427 2.32E-58 T 17-03-2017 SHXM_RS33390 b6f26de38174733525a39c92ceb9a430 458 Pfam PF12730 ABC-2 family transporter protein 30 161 8.4E-7 T 17-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 SHXM_RS50940 de7ee19f3b6c5a1b988bf6961d062dab 185 Gene3D G3DSA:1.10.10.60 25 52 1.1E-4 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50940 de7ee19f3b6c5a1b988bf6961d062dab 185 Pfam PF13384 Homeodomain-like domain 21 56 2.1E-8 T 17-03-2017 SHXM_RS29535 611364a572f2faa2817b8cff2d6e2997 674 SUPERFAMILY SSF52540 222 427 6.9E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29535 611364a572f2faa2817b8cff2d6e2997 674 Gene3D G3DSA:3.40.50.300 266 447 5.4E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15310 c103ac5ba4c9d06c8882b9ef1f69aeac 477 PIRSF PIRSF006060 8 465 7.0E-79 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS15310 c103ac5ba4c9d06c8882b9ef1f69aeac 477 Pfam PF13520 Amino acid permease 30 426 1.0E-43 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS04220 2f7f16570e91e6bba982292c0828b5bd 319 SUPERFAMILY SSF103481 44 146 4.45E-7 T 17-03-2017 SHXM_RS04220 2f7f16570e91e6bba982292c0828b5bd 319 Pfam PF00892 EamA-like transporter family 9 144 4.8E-12 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS04220 2f7f16570e91e6bba982292c0828b5bd 319 Pfam PF00892 EamA-like transporter family 159 295 2.0E-20 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS04220 2f7f16570e91e6bba982292c0828b5bd 319 SUPERFAMILY SSF103481 213 299 4.32E-9 T 17-03-2017 SHXM_RS36975 46da53e75a612536b84dabf8e7deb168 520 Pfam PF05108 Type VII secretion system ESX-1, transport TM domain B 3 516 3.5E-82 T 17-03-2017 IPR007795 Type VII secretion system EccB SHXM_RS36975 46da53e75a612536b84dabf8e7deb168 520 TIGRFAM TIGR03919 T7SS_EccB: type VII secretion protein EccB 4 452 9.8E-54 T 17-03-2017 IPR007795 Type VII secretion system EccB SHXM_RS10565 9cbd0bed4938329d310e18075e193672 271 Gene3D G3DSA:3.40.50.150 10 186 3.7E-20 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10565 9cbd0bed4938329d310e18075e193672 271 TIGRFAM TIGR00027 mthyl_TIGR00027: methyltransferase, TIGR00027 family 3 251 4.4E-83 T 17-03-2017 IPR011610 S-adenosyl-L-methionine-dependent methyltransferase, putative GO:0008168 SHXM_RS10565 9cbd0bed4938329d310e18075e193672 271 SUPERFAMILY SSF53335 1 261 1.83E-62 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10565 9cbd0bed4938329d310e18075e193672 271 Pfam PF04072 Leucine carboxyl methyltransferase 5 181 6.9E-54 T 17-03-2017 IPR007213 Methyltransferase Ppm1/Ppm2/Tcmp GO:0008168|GO:0032259 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 Gene3D G3DSA:1.20.1640.10 482 703 1.2E-32 T 17-03-2017 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 Gene3D G3DSA:1.20.1640.10 140 338 1.7E-32 T 17-03-2017 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 SUPERFAMILY SSF82866 120 332 1.44E-31 T 17-03-2017 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 SUPERFAMILY SSF82866 478 697 1.57E-27 T 17-03-2017 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 PRINTS PR00702 Acriflavin resistance protein family signature 229 253 6.2E-5 T 17-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 PRINTS PR00702 Acriflavin resistance protein family signature 176 199 6.2E-5 T 17-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 PRINTS PR00702 Acriflavin resistance protein family signature 304 327 6.2E-5 T 17-03-2017 IPR001036 Acriflavin resistance protein GO:0005215|GO:0006810|GO:0016020 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 Pfam PF03176 MMPL family 45 369 2.9E-83 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS28790 d2dd885fe2eeec1d751d35daebf49e08 753 Pfam PF03176 MMPL family 464 697 1.9E-33 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS10960 52735406f4d0f6cf6f26164f8ba2fd35 303 Gene3D G3DSA:1.10.3720.10 30 290 1.2E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10960 52735406f4d0f6cf6f26164f8ba2fd35 303 SUPERFAMILY SSF161098 33 303 1.31E-69 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10960 52735406f4d0f6cf6f26164f8ba2fd35 303 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 117 296 2.2E-19 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS05590 29ec55f03ac9d03e7a6d152b77a0ace6 71 SUPERFAMILY SSF55331 2 63 1.78E-11 T 17-03-2017 IPR014347 Tautomerase/MIF superfamily SHXM_RS05590 29ec55f03ac9d03e7a6d152b77a0ace6 71 Pfam PF01361 Tautomerase enzyme 2 61 1.0E-17 T 17-03-2017 IPR004370 4-oxalocrotonate tautomerase GO:0006725|GO:0016853 SHXM_RS05590 29ec55f03ac9d03e7a6d152b77a0ace6 71 Gene3D G3DSA:3.30.429.20 1 60 3.8E-13 T 17-03-2017 SHXM_RS22185 5f560b39a1b25a4a92f3b554263f5c59 515 PIRSF PIRSF026631 25 500 1.7E-59 T 17-03-2017 IPR014529 Uncharacterised conserved protein UCP026631 SHXM_RS22185 5f560b39a1b25a4a92f3b554263f5c59 515 Pfam PF03703 Bacterial PH domain 78 156 3.5E-16 T 17-03-2017 IPR005182 Domain of unknown function DUF304 SHXM_RS22185 5f560b39a1b25a4a92f3b554263f5c59 515 Pfam PF03703 Bacterial PH domain 429 480 1.6E-5 T 17-03-2017 IPR005182 Domain of unknown function DUF304 SHXM_RS38340 f41517d33783dc85c1b7b78dd6e6a471 564 Pfam PF09594 Protein of unknown function (DUF2029) 194 459 6.3E-10 T 17-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 Pfam PF11941 Domain of unknown function (DUF3459) 472 551 2.2E-7 T 17-03-2017 IPR022567 Glycosyl hydrolase, C-terminal (DUF3459) SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 SUPERFAMILY SSF51445 20 486 6.65E-126 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 Pfam PF00128 Alpha amylase, catalytic domain 45 392 3.8E-77 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 SMART SM00642 30 423 3.6E-127 T 17-03-2017 IPR006047 Glycosyl hydrolase, family 13, catalytic domain GO:0003824|GO:0005975 SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 Gene3D G3DSA:3.90.400.10 122 198 1.2E-28 T 17-03-2017 SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 Gene3D G3DSA:3.20.20.80 200 487 3.8E-109 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS19280 4ad31bf071cb0cd8a77dd4585767eed0 553 Gene3D G3DSA:3.20.20.80 20 121 3.8E-109 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS22230 9c0c70a9561f447c042636a606d4e693 811 Gene3D G3DSA:3.40.50.2300 440 516 3.6E-11 T 17-03-2017 SHXM_RS22230 9c0c70a9561f447c042636a606d4e693 811 Gene3D G3DSA:3.40.50.2300 689 742 3.6E-11 T 17-03-2017 SHXM_RS22230 9c0c70a9561f447c042636a606d4e693 811 SUPERFAMILY SSF53822 403 758 1.96E-10 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS04785 3123a4b221068400df28d848d4b71e59 235 Gene3D G3DSA:3.40.50.150 184 211 1.0E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04785 3123a4b221068400df28d848d4b71e59 235 Gene3D G3DSA:3.40.50.150 22 152 1.0E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04785 3123a4b221068400df28d848d4b71e59 235 SUPERFAMILY SSF53335 15 227 5.93E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS04785 3123a4b221068400df28d848d4b71e59 235 Pfam PF13649 Methyltransferase domain 32 124 3.7E-15 T 17-03-2017 SHXM_RS44195 2dc8a68a877108fb61519c971a0e5922 68 Gene3D G3DSA:3.40.50.880 1 66 2.1E-15 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS44195 2dc8a68a877108fb61519c971a0e5922 68 SUPERFAMILY SSF52317 1 66 6.41E-15 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS17335 717caa6a9fd2808e0253f30148b025bb 513 SUPERFAMILY SSF111283 13 503 5.23E-96 T 17-03-2017 SHXM_RS17335 717caa6a9fd2808e0253f30148b025bb 513 Pfam PF01523 Putative modulator of DNA gyrase 32 352 1.7E-48 T 17-03-2017 IPR002510 Metalloprotease TldD/PmbA GO:0006508|GO:0008237 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 133 148 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 105 118 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 221 231 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 302 316 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 190 203 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 251 264 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 65 84 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PRINTS PR00733 Glycosyl hydrolase family 6 signature 278 298 3.6E-40 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 PIRSF PIRSF001100 4 342 5.0E-102 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 Pfam PF01341 Glycosyl hydrolases family 6 51 321 1.2E-85 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 SUPERFAMILY SSF51989 35 339 9.03E-87 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 ProSitePatterns PS00655 Glycosyl hydrolases family 6 signature 1. 110 126 - T 17-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 SHXM_RS16285 17b4dd5e048d24cb1f744e8b7e83a498 343 Gene3D G3DSA:3.20.20.40 35 339 2.8E-97 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS35940 d4dce649eee4ad09a3abdea78e2bcd89 185 Gene3D G3DSA:1.20.1290.10 34 178 2.9E-28 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS35940 d4dce649eee4ad09a3abdea78e2bcd89 185 SUPERFAMILY SSF69118 1 175 1.57E-31 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS48810 5214a1efe0729ccba1e4e082ccd08d30 210 SUPERFAMILY SSF46689 1 77 8.72E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS48810 5214a1efe0729ccba1e4e082ccd08d30 210 Pfam PF00440 Bacterial regulatory proteins, tetR family 17 60 3.3E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48810 5214a1efe0729ccba1e4e082ccd08d30 210 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 37 60 1.3E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48810 5214a1efe0729ccba1e4e082ccd08d30 210 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 16 29 1.3E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS48810 5214a1efe0729ccba1e4e082ccd08d30 210 Gene3D G3DSA:1.10.357.10 58 199 1.4E-9 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS48810 5214a1efe0729ccba1e4e082ccd08d30 210 Gene3D G3DSA:1.10.10.60 8 57 7.8E-19 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS33800 dd7504a61acb2bff985f88d363823bb6 61 Pfam PF05036 Sporulation related domain 11 46 3.7E-5 T 17-03-2017 IPR007730 Sporulation-related domain GO:0042834 SHXM_RS33800 dd7504a61acb2bff985f88d363823bb6 61 Gene3D G3DSA:3.30.70.1070 13 50 8.1E-4 T 17-03-2017 IPR007730 Sporulation-related domain GO:0042834 SHXM_RS23600 6966c841d404d4b542e8a9c3f80030da 207 SUPERFAMILY SSF51182 14 183 6.67E-41 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS23600 6966c841d404d4b542e8a9c3f80030da 207 Pfam PF05995 Cysteine dioxygenase type I 63 166 2.1E-8 T 17-03-2017 IPR010300 Cysteine dioxygenase type I GO:0005506|GO:0016702|GO:0055114 KEGG: 00270+1.13.11.20|KEGG: 00430+1.13.11.20|MetaCyc: PWY-5331|Reactome: R-HSA-1614558 SHXM_RS23600 6966c841d404d4b542e8a9c3f80030da 207 Gene3D G3DSA:2.60.120.10 60 182 9.9E-35 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS11245 412ec27fcbd3dc14b3fb44ef621988fb 341 Pfam PF00296 Luciferase-like monooxygenase 12 307 1.3E-53 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS11245 412ec27fcbd3dc14b3fb44ef621988fb 341 Gene3D G3DSA:3.20.20.30 1 336 1.0E-66 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS11245 412ec27fcbd3dc14b3fb44ef621988fb 341 SUPERFAMILY SSF51679 1 333 7.59E-62 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS31700 070e0dfd60b0a0fa4c457352a7000d98 460 Pfam PF13416 Bacterial extracellular solute-binding protein 65 383 2.4E-42 T 17-03-2017 SHXM_RS31700 070e0dfd60b0a0fa4c457352a7000d98 460 Gene3D G3DSA:3.40.190.10 182 372 1.8E-32 T 17-03-2017 SHXM_RS31700 070e0dfd60b0a0fa4c457352a7000d98 460 Gene3D G3DSA:3.40.190.10 44 181 3.4E-11 T 17-03-2017 SHXM_RS31700 070e0dfd60b0a0fa4c457352a7000d98 460 SUPERFAMILY SSF53850 47 448 6.52E-66 T 17-03-2017 SHXM_RS09190 30087c95d0b441fa35f1e8a595415a3e 139 Pfam PF01042 Endoribonuclease L-PSP 15 134 1.4E-16 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS09190 30087c95d0b441fa35f1e8a595415a3e 139 Gene3D G3DSA:3.30.1330.40 4 136 6.9E-28 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS09190 30087c95d0b441fa35f1e8a595415a3e 139 SUPERFAMILY SSF55298 5 136 7.07E-25 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS25965 211663aa94318b4bd77aeef3d370952c 240 SUPERFAMILY SSF46894 174 228 9.86E-7 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS25965 211663aa94318b4bd77aeef3d370952c 240 Gene3D G3DSA:1.10.10.10 173 226 7.8E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS34010 17229d447999bc0af5ff5f34b9b3f190 247 Pfam PF12698 ABC-2 family transporter protein 53 239 5.7E-13 T 17-03-2017 SHXM_RS34010 17229d447999bc0af5ff5f34b9b3f190 247 PIRSF PIRSF006648 2 245 9.2E-16 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS29590 3f6ad42dc4e913578a3b8675a901f1da 458 SUPERFAMILY SSF52540 155 394 1.2E-17 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS29590 3f6ad42dc4e913578a3b8675a901f1da 458 Pfam PF01580 FtsK/SpoIIIE family 281 339 2.3E-7 T 17-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SHXM_RS29590 3f6ad42dc4e913578a3b8675a901f1da 458 Pfam PF01580 FtsK/SpoIIIE family 162 278 1.4E-16 T 17-03-2017 IPR002543 FtsK domain GO:0000166|GO:0003677|GO:0005524 SHXM_RS29590 3f6ad42dc4e913578a3b8675a901f1da 458 Gene3D G3DSA:3.40.50.300 152 377 7.0E-18 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04890 a06ea8de4cf983cd2d528a9265291e27 385 SUPERFAMILY SSF48576 90 384 4.16E-75 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS04890 a06ea8de4cf983cd2d528a9265291e27 385 Pfam PF00348 Polyprenyl synthetase 90 304 1.6E-52 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS04890 a06ea8de4cf983cd2d528a9265291e27 385 ProSitePatterns PS00444 Polyprenyl synthases signature 2. 259 271 - T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS04890 a06ea8de4cf983cd2d528a9265291e27 385 Gene3D G3DSA:1.10.600.10 49 384 1.4E-79 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS46935 bf1c7cd0dc9d26b702c5a6519f9fe53f 335 Pfam PF12833 Helix-turn-helix domain 238 318 1.7E-18 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46935 bf1c7cd0dc9d26b702c5a6519f9fe53f 335 Gene3D G3DSA:1.10.10.60 268 318 7.4E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46935 bf1c7cd0dc9d26b702c5a6519f9fe53f 335 Pfam PF14525 AraC-binding-like domain 19 197 2.3E-15 T 17-03-2017 IPR003313 AraC-type arabinose-binding/dimerisation domain GO:0006355 SHXM_RS46935 bf1c7cd0dc9d26b702c5a6519f9fe53f 335 Gene3D G3DSA:1.10.10.60 211 267 4.2E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS46935 bf1c7cd0dc9d26b702c5a6519f9fe53f 335 SMART SM00342 232 317 5.1E-20 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS46935 bf1c7cd0dc9d26b702c5a6519f9fe53f 335 SUPERFAMILY SSF46689 267 318 3.09E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS38630 8af2c8448f338dbe2af5b3ee9699aee3 759 Pfam PF03176 MMPL family 418 719 2.0E-36 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS38630 8af2c8448f338dbe2af5b3ee9699aee3 759 Pfam PF03176 MMPL family 79 383 5.3E-52 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS38630 8af2c8448f338dbe2af5b3ee9699aee3 759 SUPERFAMILY SSF82866 125 350 8.76E-30 T 17-03-2017 SHXM_RS38630 8af2c8448f338dbe2af5b3ee9699aee3 759 SUPERFAMILY SSF82866 469 715 1.44E-29 T 17-03-2017 SHXM_RS38630 8af2c8448f338dbe2af5b3ee9699aee3 759 Gene3D G3DSA:1.20.1640.10 148 351 5.4E-29 T 17-03-2017 SHXM_RS38630 8af2c8448f338dbe2af5b3ee9699aee3 759 Gene3D G3DSA:1.20.1640.10 526 720 9.9E-31 T 17-03-2017 SHXM_RS42350 76601078d24fd4e821867b7fa42f9659 160 Pfam PF00174 Oxidoreductase molybdopterin binding domain 17 127 5.2E-7 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS42350 76601078d24fd4e821867b7fa42f9659 160 Gene3D G3DSA:3.90.420.10 17 95 1.3E-10 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS42350 76601078d24fd4e821867b7fa42f9659 160 SUPERFAMILY SSF56524 17 153 1.23E-15 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS20025 545a9d900bd152626c16348644896436 260 PRINTS PR00111 Alpha/beta hydrolase fold signature 46 61 6.0E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20025 545a9d900bd152626c16348644896436 260 PRINTS PR00111 Alpha/beta hydrolase fold signature 90 103 6.0E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20025 545a9d900bd152626c16348644896436 260 PRINTS PR00111 Alpha/beta hydrolase fold signature 104 117 6.0E-7 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20025 545a9d900bd152626c16348644896436 260 Gene3D G3DSA:3.40.50.1820 12 256 1.2E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20025 545a9d900bd152626c16348644896436 260 Pfam PF00561 alpha/beta hydrolase fold 22 150 4.8E-22 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS20025 545a9d900bd152626c16348644896436 260 PRINTS PR00412 Epoxide hydrolase signature 46 61 3.0E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS20025 545a9d900bd152626c16348644896436 260 PRINTS PR00412 Epoxide hydrolase signature 233 255 3.0E-7 T 17-03-2017 IPR000639 Epoxide hydrolase-like GO:0003824 SHXM_RS20025 545a9d900bd152626c16348644896436 260 SUPERFAMILY SSF53474 12 256 2.41E-47 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS40285 0e1b16ef0c2957b2355019d7a98788dc 274 SUPERFAMILY SSF47413 29 80 4.64E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS40285 0e1b16ef0c2957b2355019d7a98788dc 274 SMART SM00530 9 81 9.7E-10 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS40285 0e1b16ef0c2957b2355019d7a98788dc 274 Pfam PF13560 Helix-turn-helix domain 6 84 8.4E-17 T 17-03-2017 SHXM_RS40285 0e1b16ef0c2957b2355019d7a98788dc 274 Gene3D G3DSA:1.10.260.40 6 80 2.8E-17 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS48820 c800d8e107d429fbeb8561c9f33643b2 370 Pfam PF13276 HTH-like domain 106 154 1.6E-6 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS48820 c800d8e107d429fbeb8561c9f33643b2 370 Gene3D G3DSA:3.30.420.10 167 324 5.1E-18 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS48820 c800d8e107d429fbeb8561c9f33643b2 370 Pfam PF13683 Integrase core domain 260 324 1.0E-11 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS48820 c800d8e107d429fbeb8561c9f33643b2 370 SUPERFAMILY SSF53098 169 326 2.28E-20 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS46185 f25c3ce8ed6e619efa6646d07515aa18 322 SUPERFAMILY SSF56317 1 298 5.23E-48 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS46185 f25c3ce8ed6e619efa6646d07515aa18 322 Gene3D G3DSA:3.60.110.10 2 298 1.6E-49 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS46185 f25c3ce8ed6e619efa6646d07515aa18 322 Pfam PF00795 Carbon-nitrogen hydrolase 5 242 4.3E-28 T 17-03-2017 IPR003010 Carbon-nitrogen hydrolase GO:0006807|GO:0016810 SHXM_RS08630 962710a94f4aa3aa5a7290d873ea7502 116 SUPERFAMILY SSF54909 18 112 5.37E-21 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS08630 962710a94f4aa3aa5a7290d873ea7502 116 Gene3D G3DSA:3.30.70.900 20 114 1.3E-27 T 17-03-2017 SHXM_RS08630 962710a94f4aa3aa5a7290d873ea7502 116 Pfam PF03992 Antibiotic biosynthesis monooxygenase 23 97 6.6E-15 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS31025 4f103f2c5c3eb8075fa4f7aab0df7ae9 425 Gene3D G3DSA:2.30.40.10 23 108 3.7E-9 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS31025 4f103f2c5c3eb8075fa4f7aab0df7ae9 425 Gene3D G3DSA:3.20.20.140 109 353 1.4E-51 T 17-03-2017 SHXM_RS31025 4f103f2c5c3eb8075fa4f7aab0df7ae9 425 SUPERFAMILY SSF51338 24 88 2.84E-6 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS31025 4f103f2c5c3eb8075fa4f7aab0df7ae9 425 SUPERFAMILY SSF51556 73 363 1.6E-43 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31890 f77e96cce0b51ca9a369e29b86c0d4a1 474 Pfam PF09594 Protein of unknown function (DUF2029) 81 351 6.5E-44 T 17-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 SHXM_RS45250 5468a0bd1aa9c1a4d52d35152e3dc531 393 SUPERFAMILY SSF69279 17 194 1.32E-13 T 17-03-2017 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 Pfam PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain 173 337 1.9E-57 T 17-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 SUPERFAMILY SSF54675 64 172 8.24E-26 T 17-03-2017 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 TIGRFAM TIGR00078 nadC: nicotinate-nucleotide diphosphorylase (carboxylating) 75 337 3.0E-91 T 17-03-2017 IPR004393 Nicotinate-nucleotide pyrophosphorylase GO:0004514|GO:0019363 KEGG: 00760+2.4.2.19|MetaCyc: PWY-5316|MetaCyc: PWY-5653|MetaCyc: PWY-7342|Reactome: R-HSA-196807 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 Gene3D G3DSA:3.20.20.70 194 328 1.3E-57 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 Pfam PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain 84 171 1.8E-22 T 17-03-2017 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 Reactome: R-HSA-196807 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 SUPERFAMILY SSF51690 173 338 1.96E-57 T 17-03-2017 IPR002638 Quinolinate phosphoribosyl transferase, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 SHXM_RS26325 81e5b64d127266a41b72a86741909294 344 Gene3D G3DSA:3.90.1170.20 62 193 3.8E-45 T 17-03-2017 IPR022412 Quinolinate phosphoribosyl transferase, N-terminal GO:0016763 Reactome: R-HSA-196807 SHXM_RS37155 6eb74eec7a5c2d4826803454ff498a1f 225 Pfam PF00072 Response regulator receiver domain 7 119 1.5E-24 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37155 6eb74eec7a5c2d4826803454ff498a1f 225 SMART SM00448 5 119 7.4E-31 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS37155 6eb74eec7a5c2d4826803454ff498a1f 225 SUPERFAMILY SSF52172 3 145 1.85E-37 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS37155 6eb74eec7a5c2d4826803454ff498a1f 225 Gene3D G3DSA:3.40.50.2300 3 126 8.8E-36 T 17-03-2017 SHXM_RS05675 0bd98aa00e62f14a16ce8feed13b5b8b 372 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 11 356 1.5E-62 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS05675 0bd98aa00e62f14a16ce8feed13b5b8b 372 SUPERFAMILY SSF51395 7 356 7.63E-95 T 17-03-2017 SHXM_RS05675 0bd98aa00e62f14a16ce8feed13b5b8b 372 Gene3D G3DSA:3.20.20.70 7 358 1.1E-101 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS14760 37d4e55f99ad2cd053856c5f89ae88cc 284 TIGRFAM TIGR00473 pssA: CDP-diacylglycerol-serine O-phosphatidyltransferase 38 210 1.8E-32 T 17-03-2017 IPR004533 CDP-diacylglycerol--serine O-phosphatidyltransferase KEGG: 00260+2.7.8.8|KEGG: 00564+2.7.8.8|MetaCyc: PWY-5669 SHXM_RS14760 37d4e55f99ad2cd053856c5f89ae88cc 284 Pfam PF01066 CDP-alcohol phosphatidyltransferase 33 112 4.8E-12 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS14760 37d4e55f99ad2cd053856c5f89ae88cc 284 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 91 112 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS18250 f1c1b0f9672bc998b0bc241f4f8b4457 157 SUPERFAMILY SSF50475 14 140 7.69E-32 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18250 f1c1b0f9672bc998b0bc241f4f8b4457 157 TIGRFAM TIGR03618 Rv1155_F420: PPOX class probable F420-dependent enzyme 17 141 2.2E-40 T 17-03-2017 IPR019920 F420-binding domain, putative SHXM_RS18250 f1c1b0f9672bc998b0bc241f4f8b4457 157 Gene3D G3DSA:2.30.110.10 14 145 1.3E-30 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS18250 f1c1b0f9672bc998b0bc241f4f8b4457 157 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 14 98 1.3E-15 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS42960 c783938d3d92b7804d2862b5befb26d0 476 SUPERFAMILY SSF103473 257 458 1.7E-58 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS42960 c783938d3d92b7804d2862b5befb26d0 476 SUPERFAMILY SSF103473 16 211 1.7E-58 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS42960 c783938d3d92b7804d2862b5befb26d0 476 Gene3D G3DSA:1.20.1250.20 282 457 8.3E-24 T 17-03-2017 SHXM_RS42960 c783938d3d92b7804d2862b5befb26d0 476 Gene3D G3DSA:1.20.1250.20 27 210 1.4E-26 T 17-03-2017 SHXM_RS42960 c783938d3d92b7804d2862b5befb26d0 476 Pfam PF07690 Major Facilitator Superfamily 37 419 3.1E-44 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS42040 696eaf6fe43efd1d2da3554a44a45dc3 300 Gene3D G3DSA:3.10.129.10 12 117 2.5E-30 T 17-03-2017 IPR029069 HotDog domain SHXM_RS42040 696eaf6fe43efd1d2da3554a44a45dc3 300 Gene3D G3DSA:3.10.129.10 132 299 3.3E-42 T 17-03-2017 IPR029069 HotDog domain SHXM_RS42040 696eaf6fe43efd1d2da3554a44a45dc3 300 SUPERFAMILY SSF54637 130 299 1.13E-38 T 17-03-2017 IPR029069 HotDog domain SHXM_RS42040 696eaf6fe43efd1d2da3554a44a45dc3 300 Pfam PF13622 Thioesterase-like superfamily 36 297 5.0E-50 T 17-03-2017 SHXM_RS42040 696eaf6fe43efd1d2da3554a44a45dc3 300 SUPERFAMILY SSF54637 28 121 2.49E-29 T 17-03-2017 IPR029069 HotDog domain SHXM_RS02255 a8152a73dc344ca8c9aa5ab82953ed3b 445 Gene3D G3DSA:3.20.20.70 142 351 5.5E-5 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS02255 a8152a73dc344ca8c9aa5ab82953ed3b 445 SUPERFAMILY SSF102114 143 363 6.47E-7 T 17-03-2017 SHXM_RS42745 69a65a238dd265754aaff303ae51e958 362 Gene3D G3DSA:2.130.10.10 5 358 7.7E-86 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS42745 69a65a238dd265754aaff303ae51e958 362 SUPERFAMILY SSF110296 4 360 1.57E-60 T 17-03-2017 SHXM_RS04935 0305b71d306ff54f5f3d31084fa22543 351 Gene3D G3DSA:3.90.1550.10 90 347 9.8E-65 T 17-03-2017 SHXM_RS04935 0305b71d306ff54f5f3d31084fa22543 351 SUPERFAMILY SSF55681 92 347 6.25E-67 T 17-03-2017 SHXM_RS04935 0305b71d306ff54f5f3d31084fa22543 351 Pfam PF03099 Biotin/lipoate A/B protein ligase family 159 265 3.3E-7 T 17-03-2017 IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain GO:0006464 SHXM_RS17210 b3d24424596962f068bbe06f0cfc0b0e 111 Pfam PF01337 Barstar (barnase inhibitor) 12 98 3.1E-25 T 17-03-2017 IPR000468 Barstar (barnase inhibitor) SHXM_RS17210 b3d24424596962f068bbe06f0cfc0b0e 111 SUPERFAMILY SSF52038 11 103 5.23E-22 T 17-03-2017 IPR000468 Barstar (barnase inhibitor) SHXM_RS17210 b3d24424596962f068bbe06f0cfc0b0e 111 Gene3D G3DSA:3.30.370.10 11 101 7.3E-23 T 17-03-2017 IPR000468 Barstar (barnase inhibitor) SHXM_RS23960 d7f2fc28bcd22ac6a83eaaf7f775ee21 106 SUPERFAMILY SSF46785 6 94 8.97E-14 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23960 d7f2fc28bcd22ac6a83eaaf7f775ee21 106 Gene3D G3DSA:1.10.10.10 4 95 2.6E-19 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23960 d7f2fc28bcd22ac6a83eaaf7f775ee21 106 Pfam PF13601 Winged helix DNA-binding domain 15 93 1.4E-23 T 17-03-2017 IPR027395 Winged helix DNA-binding domain SHXM_RS30685 d3f908a4907e4c54e99126da71fa8cc8 204 Gene3D G3DSA:1.10.357.10 1 190 1.8E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS30685 d3f908a4907e4c54e99126da71fa8cc8 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 1 14 9.8E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30685 d3f908a4907e4c54e99126da71fa8cc8 204 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 22 45 9.8E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30685 d3f908a4907e4c54e99126da71fa8cc8 204 Pfam PF00440 Bacterial regulatory proteins, tetR family 2 47 2.2E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS30685 d3f908a4907e4c54e99126da71fa8cc8 204 SUPERFAMILY SSF46689 2 69 7.18E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS14905 1aa459325defec5d7d8003ec119c837a 250 Pfam PF01061 ABC-2 type transporter 9 214 1.9E-24 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS14905 1aa459325defec5d7d8003ec119c837a 250 PIRSF PIRSF006648 1 249 2.0E-43 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 Gene3D G3DSA:2.60.40.1180 431 499 1.4E-18 T 17-03-2017 IPR013780 Glycosyl hydrolase, all-beta SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 Gene3D G3DSA:3.20.20.80 81 430 1.1E-116 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 Pfam PF02055 Glycosyl hydrolase family 30 TIM-barrel domain 99 395 4.7E-35 T 17-03-2017 IPR033453 Glycosyl hydrolase family 30, TIM-barrel domain Reactome: R-HSA-1660662|Reactome: R-HSA-390471 SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 Pfam PF17189 Glycosyl hydrolase family 30 beta sandwich domain 437 496 1.5E-14 T 17-03-2017 IPR033452 Glycosyl hydrolase family 30, beta sandwich domain Reactome: R-HSA-1660662|Reactome: R-HSA-390471 SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 SUPERFAMILY SSF51445 98 438 1.21E-65 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 SUPERFAMILY SSF51011 433 498 6.98E-7 T 17-03-2017 SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 PRINTS PR00843 Glycosyl hydrolase family 30 signature 87 107 8.6E-6 T 17-03-2017 IPR001139 Glycoside hydrolase family 30 GO:0004348|GO:0006665 Reactome: R-HSA-1660662|Reactome: R-HSA-390471 SHXM_RS30995 1832be63cadd5a61cdc7f15d06443a3c 503 PRINTS PR00843 Glycosyl hydrolase family 30 signature 222 239 8.6E-6 T 17-03-2017 IPR001139 Glycoside hydrolase family 30 GO:0004348|GO:0006665 Reactome: R-HSA-1660662|Reactome: R-HSA-390471 SHXM_RS42935 6a18865114bf27ba571d9a768c717e29 120 Pfam PF06108 Protein of unknown function (DUF952) 6 101 3.6E-19 T 17-03-2017 IPR009297 Protein of unknown function DUF952 SHXM_RS42935 6a18865114bf27ba571d9a768c717e29 120 SUPERFAMILY SSF56399 1 112 1.27E-18 T 17-03-2017 SHXM_RS21985 ca2df47edf6e445eacccac194fa09fa0 134 Pfam PF01152 Bacterial-like globin 13 129 3.8E-35 T 17-03-2017 IPR001486 Truncated hemoglobin GO:0019825 SHXM_RS21985 ca2df47edf6e445eacccac194fa09fa0 134 SUPERFAMILY SSF46458 12 132 3.91E-38 T 17-03-2017 IPR009050 Globin-like SHXM_RS21985 ca2df47edf6e445eacccac194fa09fa0 134 Gene3D G3DSA:1.10.490.10 11 133 3.9E-46 T 17-03-2017 IPR012292 Globin/Protoglobin GO:0019825|GO:0020037 SHXM_RS40805 d5ede9644c9182f77262f514f89d1a74 424 SUPERFAMILY SSF103473 15 421 1.57E-60 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS40805 d5ede9644c9182f77262f514f89d1a74 424 Pfam PF07690 Major Facilitator Superfamily 25 284 4.9E-18 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS40805 d5ede9644c9182f77262f514f89d1a74 424 Gene3D G3DSA:1.20.1250.20 235 417 4.1E-20 T 17-03-2017 SHXM_RS40805 d5ede9644c9182f77262f514f89d1a74 424 Gene3D G3DSA:1.20.1250.20 15 214 1.7E-22 T 17-03-2017 SHXM_RS40805 d5ede9644c9182f77262f514f89d1a74 424 ProSitePatterns PS00216 Sugar transport proteins signature 1. 77 93 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS24255 f5d73920e75e355c98812a1556425050 372 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 98 253 1.9E-45 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24255 f5d73920e75e355c98812a1556425050 372 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 98 253 1.7E-46 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS35965 82abe09e8f35b00789f23947b0298c9f 232 Gene3D G3DSA:3.40.50.300 59 191 1.8E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35965 82abe09e8f35b00789f23947b0298c9f 232 SUPERFAMILY SSF52540 58 184 7.62E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35965 82abe09e8f35b00789f23947b0298c9f 232 Pfam PF13671 AAA domain 59 197 1.1E-6 T 17-03-2017 SHXM_RS16470 56fab889880605e4c8e26374c3126f3c 750 Pfam PF03176 MMPL family 417 721 4.0E-29 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS16470 56fab889880605e4c8e26374c3126f3c 750 Pfam PF03176 MMPL family 44 380 4.2E-48 T 17-03-2017 IPR004869 Membrane transport protein, MMPL domain GO:0016020 SHXM_RS16470 56fab889880605e4c8e26374c3126f3c 750 Gene3D G3DSA:1.20.1640.10 503 722 4.4E-26 T 17-03-2017 SHXM_RS16470 56fab889880605e4c8e26374c3126f3c 750 Gene3D G3DSA:1.20.1640.10 136 339 1.9E-32 T 17-03-2017 SHXM_RS16470 56fab889880605e4c8e26374c3126f3c 750 SUPERFAMILY SSF82866 120 337 1.7E-34 T 17-03-2017 SHXM_RS16470 56fab889880605e4c8e26374c3126f3c 750 SUPERFAMILY SSF82866 518 717 3.14E-23 T 17-03-2017 SHXM_RS04585 873ab1cf73b6dbeedbb3a98171463117 477 Gene3D G3DSA:1.10.630.10 97 390 4.5E-26 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04585 873ab1cf73b6dbeedbb3a98171463117 477 Pfam PF00067 Cytochrome P450 236 393 2.3E-12 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS04585 873ab1cf73b6dbeedbb3a98171463117 477 SUPERFAMILY SSF48264 92 392 8.12E-29 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS17850 95c5ebc5dff97f1423fd88452a3f0635 330 Pfam PF02628 Cytochrome oxidase assembly protein 25 294 5.2E-19 T 17-03-2017 IPR003780 COX15/CtaA family GO:0006784|GO:0016021|GO:0016627|GO:0055114 Reactome: R-HSA-189451 SHXM_RS44300 cd4de7bc2460f55e6d62da34714f0fce 208 Gene3D G3DSA:2.60.120.10 26 131 5.7E-26 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS44300 cd4de7bc2460f55e6d62da34714f0fce 208 SUPERFAMILY SSF51182 20 186 1.16E-28 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS44300 cd4de7bc2460f55e6d62da34714f0fce 208 Pfam PF05962 HutD 26 187 2.5E-27 T 17-03-2017 IPR010282 Uncharacterised protein family HutD/Ves SHXM_RS38535 299be9a26d517266940a248b8e8e21af 443 Pfam PF01179 Copper amine oxidase, enzyme domain 63 426 1.9E-37 T 17-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 SHXM_RS38535 299be9a26d517266940a248b8e8e21af 443 Gene3D G3DSA:2.70.98.20 52 427 5.4E-62 T 17-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 SHXM_RS38535 299be9a26d517266940a248b8e8e21af 443 SUPERFAMILY SSF49998 49 428 3.01E-70 T 17-03-2017 IPR015798 Copper amine oxidase, C-terminal GO:0005507|GO:0008131|GO:0009308|GO:0048038|GO:0055114 Reactome: R-HSA-211945 SHXM_RS28410 30efbd3d4c3b5e41686a770d817323b5 189 Pfam PF10759 Protein of unknown function (DUF2587) 37 175 8.6E-78 T 17-03-2017 IPR019695 Bacterial proteasome activator GO:0061136 SHXM_RS37765 28df548bb142fa12bc01175363ee34a7 331 Gene3D G3DSA:3.10.129.10 187 300 9.4E-5 T 17-03-2017 IPR029069 HotDog domain SHXM_RS37765 28df548bb142fa12bc01175363ee34a7 331 SUPERFAMILY SSF54637 189 291 4.3E-7 T 17-03-2017 IPR029069 HotDog domain SHXM_RS37765 28df548bb142fa12bc01175363ee34a7 331 Gene3D G3DSA:3.10.129.10 34 133 2.5E-4 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23845 d8188420d83b25a5f343d59bb6bfba98 303 PIRSF PIRSF003097 1 303 1.6E-76 T 17-03-2017 IPR004513 Cell division protein FtsX GO:0007049|GO:0016021 SHXM_RS23845 d8188420d83b25a5f343d59bb6bfba98 303 Pfam PF02687 FtsX-like permease family 184 302 1.3E-11 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS28905 e3411e085527e91b3328b3be2c6a7fa4 248 SUPERFAMILY SSF69318 58 198 7.32E-8 T 17-03-2017 SHXM_RS21640 9802a3dfd1bf8ecb21655a81d63d7b87 236 TIGRFAM TIGR03426 shape_MreD: rod shape-determining protein MreD 5 158 6.0E-19 T 17-03-2017 IPR007227 Cell shape-determining protein MreD GO:0008360|GO:0016021 SHXM_RS21640 9802a3dfd1bf8ecb21655a81d63d7b87 236 Pfam PF04093 rod shape-determining protein MreD 4 127 1.8E-7 T 17-03-2017 IPR007227 Cell shape-determining protein MreD GO:0008360|GO:0016021 SHXM_RS28220 b396b0c996ed0ebd2f4b7e214532ac9b 256 Pfam PF05949 Bacterial protein of unknown function (DUF881) 99 253 2.4E-41 T 17-03-2017 IPR010273 Protein of unknown function DUF881 SHXM_RS26370 31f27a0159c8d4a0269c2d92e6e31cd1 398 Pfam PF07730 Histidine kinase 187 252 2.7E-21 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS26370 31f27a0159c8d4a0269c2d92e6e31cd1 398 SUPERFAMILY SSF55874 270 394 5.42E-17 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26370 31f27a0159c8d4a0269c2d92e6e31cd1 398 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 299 395 4.4E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26370 31f27a0159c8d4a0269c2d92e6e31cd1 398 Gene3D G3DSA:3.30.565.10 279 396 4.5E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS34615 aa52a9d19b36f608c2b1a4de0b9bbc78 85 Pfam PF02467 Transcription factor WhiB 3 71 1.1E-27 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS34615 aa52a9d19b36f608c2b1a4de0b9bbc78 85 Hamap MF_01479 Transcriptional regulator WhiB [whiB]. 1 76 19.172 T 17-03-2017 IPR003482 Transcription factor WhiB SHXM_RS06250 6e39c71fcdf9a869dd69fab44fd292b6 447 Gene3D G3DSA:1.20.1250.20 45 236 7.5E-20 T 17-03-2017 SHXM_RS06250 6e39c71fcdf9a869dd69fab44fd292b6 447 SUPERFAMILY SSF103473 42 444 2.62E-38 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS06250 6e39c71fcdf9a869dd69fab44fd292b6 447 Gene3D G3DSA:1.20.1250.20 264 440 1.7E-8 T 17-03-2017 SHXM_RS06250 6e39c71fcdf9a869dd69fab44fd292b6 447 Pfam PF05977 Transmembrane secretion effector 46 443 1.1E-35 T 17-03-2017 IPR010290 Transmembrane secretion effector SHXM_RS36835 f67e7c773732d319417434f3eece480b 342 Gene3D G3DSA:1.10.3720.10 47 329 4.4E-45 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36835 f67e7c773732d319417434f3eece480b 342 SUPERFAMILY SSF161098 97 326 1.57E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36835 f67e7c773732d319417434f3eece480b 342 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 130 327 1.0E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 Gene3D G3DSA:3.50.50.60 279 348 1.8E-4 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 Pfam PF13738 Pyridine nucleotide-disulphide oxidoreductase 8 207 2.3E-22 T 17-03-2017 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 7 26 4.9E-9 T 17-03-2017 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 172 190 4.9E-9 T 17-03-2017 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 281 297 4.9E-9 T 17-03-2017 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 6 28 3.2E-11 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 PRINTS PR00469 Pyridine nucleotide disulphide reductase class-II signature 168 192 3.2E-11 T 17-03-2017 IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II GO:0016491|GO:0055114 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 Gene3D G3DSA:3.50.50.60 150 209 1.9E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 Gene3D G3DSA:3.50.50.60 255 278 1.9E-25 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 SUPERFAMILY SSF51905 6 352 2.22E-37 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS11335 7456808d76573380070eb5fd39303f4e 367 Gene3D G3DSA:3.50.50.60 1 149 6.0E-23 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS06795 87025561ce8613e478103eebe1912e36 265 Gene3D G3DSA:3.40.50.1820 1 233 2.6E-49 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06795 87025561ce8613e478103eebe1912e36 265 Pfam PF12697 Alpha/beta hydrolase family 2 228 1.9E-17 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS06795 87025561ce8613e478103eebe1912e36 265 SUPERFAMILY SSF53474 2 232 2.73E-48 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS17790 aed0aa57006bf071c5a151cf582ba55e 191 Pfam PF00440 Bacterial regulatory proteins, tetR family 13 59 1.6E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS17790 aed0aa57006bf071c5a151cf582ba55e 191 Gene3D G3DSA:1.10.357.10 8 178 1.6E-32 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS17790 aed0aa57006bf071c5a151cf582ba55e 191 SUPERFAMILY SSF48498 82 177 2.04E-9 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS17790 aed0aa57006bf071c5a151cf582ba55e 191 SUPERFAMILY SSF46689 3 80 6.67E-17 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS17790 aed0aa57006bf071c5a151cf582ba55e 191 Pfam PF13977 Bacterial transcriptional repressor 88 176 3.1E-6 T 17-03-2017 SHXM_RS37315 ffc660f2f468611a5132dc6ae7228cc5 256 SUPERFAMILY SSF53213 11 255 1.29E-9 T 17-03-2017 IPR004183 Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B GO:0006725|GO:0008198|GO:0016491 SHXM_RS08505 787665945213d7d6fe6b2666b29531e5 131 Gene3D G3DSA:3.10.180.10 8 119 3.3E-10 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS08505 787665945213d7d6fe6b2666b29531e5 131 SUPERFAMILY SSF54593 4 119 9.63E-13 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS46870 c87dfef05c8c0cf6e961d81e22011308 428 Pfam PF06808 Tripartite ATP-independent periplasmic transporter, DctM component 13 426 8.9E-7 T 17-03-2017 IPR010656 TRAP C4-dicarboxylate transport system permease DctM subunit SHXM_RS07335 f2e3e39fa14abd4fa8249dcdfd23f7dd 269 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 156 190 1.8E-9 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS07335 f2e3e39fa14abd4fa8249dcdfd23f7dd 269 SUPERFAMILY SSF51161 68 212 2.36E-33 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS07335 f2e3e39fa14abd4fa8249dcdfd23f7dd 269 ProSitePatterns PS00101 Hexapeptide-repeat containing-transferases signature. 164 192 - T 17-03-2017 IPR018357 Hexapeptide transferase, conserved site GO:0016740 Reactome: R-HSA-446205 SHXM_RS07335 f2e3e39fa14abd4fa8249dcdfd23f7dd 269 Gene3D G3DSA:2.160.10.10 65 213 1.2E-36 T 17-03-2017 SHXM_RS32875 e34d6d20e42b2abe94d485d09bd2a607 390 SMART SM00331 156 364 9.4E-17 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS32875 e34d6d20e42b2abe94d485d09bd2a607 390 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 182 364 1.6E-30 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS32875 e34d6d20e42b2abe94d485d09bd2a607 390 SUPERFAMILY SSF81606 170 365 2.22E-9 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS32875 e34d6d20e42b2abe94d485d09bd2a607 390 Gene3D G3DSA:3.60.40.10 291 364 7.5E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS18230 21458b08fd110a1e3495e29e3e09386b 113 SUPERFAMILY SSF48600 19 108 5.8E-25 T 17-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS18230 21458b08fd110a1e3495e29e3e09386b 113 Gene3D G3DSA:1.20.59.10 23 108 9.5E-20 T 17-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS18230 21458b08fd110a1e3495e29e3e09386b 113 Pfam PF01817 Chorismate mutase type II 30 105 4.3E-17 T 17-03-2017 IPR020822 Chorismate mutase, type II GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS18230 21458b08fd110a1e3495e29e3e09386b 113 TIGRFAM TIGR01795 CM_mono_cladeE: chorismate mutase 23 112 1.0E-46 T 17-03-2017 IPR010951 Chorismate mutase, bacteria SHXM_RS18230 21458b08fd110a1e3495e29e3e09386b 113 SMART SM00830 30 110 3.5E-22 T 17-03-2017 IPR002701 Chorismate mutase GO:0046417 KEGG: 00400+5.4.99.5|MetaCyc: PWY-3461|MetaCyc: PWY-3462|MetaCyc: PWY-6120|MetaCyc: PWY-6627|MetaCyc: PWY-7626 SHXM_RS38670 e674ce31a5d6c5663585756c13602cef 270 Gene3D G3DSA:3.40.50.300 1 131 1.1E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38670 e674ce31a5d6c5663585756c13602cef 270 SUPERFAMILY SSF52540 1 133 1.09E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS38805 a5546ef07a069ce9232e6f8d2d21de5a 657 Pfam PF13672 Protein phosphatase 2C 373 636 2.7E-20 T 17-03-2017 SHXM_RS10820 1da218b54b270ba3638f537e287554fd 373 Gene3D G3DSA:1.20.1250.20 164 349 1.2E-19 T 17-03-2017 SHXM_RS10820 1da218b54b270ba3638f537e287554fd 373 Gene3D G3DSA:1.20.1250.20 1 145 2.5E-23 T 17-03-2017 SHXM_RS10820 1da218b54b270ba3638f537e287554fd 373 Pfam PF07690 Major Facilitator Superfamily 2 305 1.0E-30 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS10820 1da218b54b270ba3638f537e287554fd 373 SUPERFAMILY SSF103473 1 346 1.44E-54 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36465 d357b05de36dad16077a73cf3dc0993a 157 Pfam PF01638 HxlR-like helix-turn-helix 36 122 2.0E-24 T 17-03-2017 IPR002577 Helix-turn-helix, HxlR type SHXM_RS36465 d357b05de36dad16077a73cf3dc0993a 157 SUPERFAMILY SSF46785 21 134 2.21E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS36465 d357b05de36dad16077a73cf3dc0993a 157 Gene3D G3DSA:1.10.10.10 19 133 6.4E-41 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS10430 7b3db2b8cc2a98ed202786d06c6e3eec 94 Gene3D G3DSA:3.40.30.10 10 82 2.9E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS10430 7b3db2b8cc2a98ed202786d06c6e3eec 94 SUPERFAMILY SSF52833 10 74 2.82E-11 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS10430 7b3db2b8cc2a98ed202786d06c6e3eec 94 Pfam PF00462 Glutaredoxin 10 68 1.0E-9 T 17-03-2017 IPR002109 Glutaredoxin GO:0009055|GO:0015035|GO:0045454 SHXM_RS23300 3b2629ff2767e994cd505c570b476f70 288 SUPERFAMILY SSF56529 67 284 9.94E-75 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS23300 3b2629ff2767e994cd505c570b476f70 288 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 78 284 8.4E-66 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS23300 3b2629ff2767e994cd505c570b476f70 288 Gene3D G3DSA:3.90.850.10 71 286 8.6E-84 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS01725 dd56b1e07aab2c529e146eb11d722ada 355 Gene3D G3DSA:3.60.15.10 133 260 3.6E-8 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01725 dd56b1e07aab2c529e146eb11d722ada 355 SUPERFAMILY SSF56281 131 256 3.58E-9 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 241 261 7.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 181 200 7.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 106 117 7.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 202 219 7.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 42 59 7.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 155 171 7.9E-32 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 Gene3D G3DSA:3.40.50.720 40 279 6.3E-65 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 106 117 4.7E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 161 169 4.7E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 PRINTS PR00080 Short-chain dehydrogenase/reductase (SDR) superfamily signature 181 200 4.7E-6 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS15610 34471046f040931a22bf0af722878547 283 SUPERFAMILY SSF51735 40 279 3.78E-61 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS15610 34471046f040931a22bf0af722878547 283 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 49 278 1.5E-48 T 17-03-2017 SHXM_RS15610 34471046f040931a22bf0af722878547 283 ProSitePatterns PS00061 Short-chain dehydrogenases/reductases family signature. 168 196 - T 17-03-2017 IPR020904 Short-chain dehydrogenase/reductase, conserved site GO:0016491 SHXM_RS26545 8427ec8f5dee55259d70a80c4edb3db5 93 Pfam PF04149 Domain of unknown function (DUF397) 26 78 9.4E-17 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS38935 93d02701c9cf1309ad42af54ad6f7e64 83 Gene3D G3DSA:3.30.70.930 24 77 1.9E-4 T 17-03-2017 IPR029756 MTH1187/YkoF-like SHXM_RS38935 93d02701c9cf1309ad42af54ad6f7e64 83 SUPERFAMILY SSF89957 3 77 1.88E-6 T 17-03-2017 IPR029756 MTH1187/YkoF-like SHXM_RS11525 0549a12e244b5c4be88e69ab08bdc63a 201 Pfam PF04186 FxsA cytoplasmic membrane protein 27 132 1.8E-27 T 17-03-2017 IPR007313 FxsA cytoplasmic membrane protein GO:0016020 SHXM_RS14230 0be3d91b4a5bd8c889e433a1848b77ea 493 Pfam PF07690 Major Facilitator Superfamily 12 367 3.3E-34 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS14230 0be3d91b4a5bd8c889e433a1848b77ea 493 Gene3D G3DSA:1.20.1250.20 213 429 5.8E-18 T 17-03-2017 SHXM_RS14230 0be3d91b4a5bd8c889e433a1848b77ea 493 Gene3D G3DSA:1.20.1250.20 5 191 9.3E-17 T 17-03-2017 SHXM_RS14230 0be3d91b4a5bd8c889e433a1848b77ea 493 SUPERFAMILY SSF103473 4 415 1.7E-48 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS14815 1f7326426ecb9f681e2902504f0c9c0a 733 Gene3D G3DSA:2.40.10.10 162 210 8.4E-4 T 17-03-2017 SHXM_RS14815 1f7326426ecb9f681e2902504f0c9c0a 733 Pfam PF13365 Trypsin-like peptidase domain 27 185 3.8E-10 T 17-03-2017 SHXM_RS14815 1f7326426ecb9f681e2902504f0c9c0a 733 SUPERFAMILY SSF50494 21 206 1.25E-14 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS47765 fd288601b15d0517d47fa07270410098 523 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 21 436 8.7E-40 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS47765 fd288601b15d0517d47fa07270410098 523 PIRSF PIRSF002744 1 484 6.4E-85 T 17-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 SHXM_RS00740 af28cf4963e54c71ea3e1c634c9cf554 718 Pfam PF02538 Hydantoinase B/oxoprolinase 14 568 2.4E-126 T 17-03-2017 IPR003692 Hydantoinase B/oxoprolinase GO:0003824 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS33060 909bc37c8a42630fc85edc1de3ea356c 109 Gene3D G3DSA:3.40.50.150 4 44 1.1E-4 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS33060 909bc37c8a42630fc85edc1de3ea356c 109 SUPERFAMILY SSF53335 4 43 8.72E-5 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20875 5e8a44ba1441ca4bf3a012e9ff65f4a7 205 Gene3D G3DSA:1.10.10.60 11 61 6.9E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20875 5e8a44ba1441ca4bf3a012e9ff65f4a7 205 Gene3D G3DSA:1.10.357.10 62 192 2.3E-22 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS20875 5e8a44ba1441ca4bf3a012e9ff65f4a7 205 SUPERFAMILY SSF46689 8 87 7.98E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS20875 5e8a44ba1441ca4bf3a012e9ff65f4a7 205 Pfam PF00440 Bacterial regulatory proteins, tetR family 28 63 1.5E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 SUPERFAMILY SSF52540 515 733 1.63E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 SUPERFAMILY SSF52540 173 252 1.63E-47 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 Pfam PF13245 Part of AAA domain 188 252 2.8E-15 T 17-03-2017 SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 Pfam PF13538 UvrD-like helicase C-terminal domain 692 729 1.8E-6 T 17-03-2017 IPR027785 UvrD-like helicase C-terminal domain SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 Gene3D G3DSA:3.40.50.300 174 282 3.2E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 Gene3D G3DSA:3.40.50.300 498 597 3.2E-29 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS04165 ab715cf4a7e973f84fb1aed984f084c6 783 Gene3D G3DSA:3.40.50.300 598 741 3.0E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS16080 cd10296dd98478e7d7c0d69c42cb165a 268 SUPERFAMILY SSF47240 18 182 9.23E-8 T 17-03-2017 IPR009078 Ferritin-like superfamily SHXM_RS06530 0d0615d5f9e31a41a1c176debd091d52 181 Pfam PF00583 Acetyltransferase (GNAT) family 62 153 1.8E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS06530 0d0615d5f9e31a41a1c176debd091d52 181 SUPERFAMILY SSF55729 6 166 8.41E-26 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS06530 0d0615d5f9e31a41a1c176debd091d52 181 Gene3D G3DSA:3.40.630.30 3 162 6.9E-26 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS26940 1ebbf4813caba2bd4be01302c99e89fe 275 Gene3D G3DSA:1.10.3290.10 42 250 9.3E-5 T 17-03-2017 IPR003812 Fido domain SHXM_RS26940 1ebbf4813caba2bd4be01302c99e89fe 275 SUPERFAMILY SSF140931 126 252 8.37E-5 T 17-03-2017 IPR003812 Fido domain SHXM_RS44140 781a4b248b9ceaa4da8b4f986e07162b 299 SUPERFAMILY SSF53335 28 269 2.37E-30 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44140 781a4b248b9ceaa4da8b4f986e07162b 299 Pfam PF02353 Mycolic acid cyclopropane synthetase 84 166 1.7E-11 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS44140 781a4b248b9ceaa4da8b4f986e07162b 299 Gene3D G3DSA:3.40.50.150 29 270 1.1E-33 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS42375 f4c791e77c551a29468e5cff3dc61468 210 SUPERFAMILY SSF161098 7 209 2.75E-51 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42375 f4c791e77c551a29468e5cff3dc61468 210 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 26 202 3.2E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS42375 f4c791e77c551a29468e5cff3dc61468 210 Gene3D G3DSA:1.10.3720.10 10 198 1.1E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS08265 1bd72cd9859e0f751f2817feb162f8d7 96 PRINTS PR01217 Proline rich extensin signature 60 76 1.2E-9 T 17-03-2017 SHXM_RS08265 1bd72cd9859e0f751f2817feb162f8d7 96 PRINTS PR01217 Proline rich extensin signature 39 60 1.2E-9 T 17-03-2017 SHXM_RS08265 1bd72cd9859e0f751f2817feb162f8d7 96 PRINTS PR01217 Proline rich extensin signature 17 29 1.2E-9 T 17-03-2017 SHXM_RS13320 131f00ae40f83192c0b59c59620b919e 256 Pfam PF01048 Phosphorylase superfamily 37 198 3.9E-16 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS13320 131f00ae40f83192c0b59c59620b919e 256 SUPERFAMILY SSF53167 12 202 2.75E-21 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS13320 131f00ae40f83192c0b59c59620b919e 256 Gene3D G3DSA:3.40.50.1580 36 202 6.2E-19 T 17-03-2017 IPR000845 Nucleoside phosphorylase domain GO:0003824|GO:0009116 SHXM_RS43750 83ea9d3d17af4a9b4e10aad691186d3e 488 SUPERFAMILY SSF53720 2 479 6.02E-160 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS43750 83ea9d3d17af4a9b4e10aad691186d3e 488 Gene3D G3DSA:3.40.605.10 3 261 1.4E-94 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS43750 83ea9d3d17af4a9b4e10aad691186d3e 488 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 247 254 - T 17-03-2017 IPR029510 Aldehyde dehydrogenase, glutamic acid active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS43750 83ea9d3d17af4a9b4e10aad691186d3e 488 ProSitePatterns PS00070 Aldehyde dehydrogenases cysteine active site. 275 286 - T 17-03-2017 IPR016160 Aldehyde dehydrogenase, cysteine active site GO:0008152|GO:0016491|GO:0055114 SHXM_RS43750 83ea9d3d17af4a9b4e10aad691186d3e 488 Gene3D G3DSA:3.40.309.10 262 441 4.0E-62 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS43750 83ea9d3d17af4a9b4e10aad691186d3e 488 Pfam PF00171 Aldehyde dehydrogenase family 10 475 2.2E-160 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS34470 c1539eb2079284ae38c64b9359614162 486 SUPERFAMILY SSF109604 251 425 2.26E-38 T 17-03-2017 SHXM_RS34470 c1539eb2079284ae38c64b9359614162 486 Pfam PF01966 HD domain 268 388 3.2E-19 T 17-03-2017 IPR006674 HD domain SHXM_RS34470 c1539eb2079284ae38c64b9359614162 486 SMART SM00471 262 397 9.6E-12 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS34470 c1539eb2079284ae38c64b9359614162 486 Gene3D G3DSA:1.10.3210.10 255 430 4.2E-22 T 17-03-2017 IPR006674 HD domain SHXM_RS30675 d45d1be10f33abd33bfdbc17556803db 106 SUPERFAMILY SSF103481 6 100 8.37E-18 T 17-03-2017 SHXM_RS30675 d45d1be10f33abd33bfdbc17556803db 106 Pfam PF00893 Small Multidrug Resistance protein 1 93 1.3E-29 T 17-03-2017 IPR000390 Small multidrug resistance protein family GO:0016021 SHXM_RS18160 d7240f1158ea7fd422640d70eae84752 584 Pfam PF02653 Branched-chain amino acid transport system / permease component 256 541 9.8E-42 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS11035 ddfd97306f89b07a77e35e2e18f95359 145 SUPERFAMILY SSF46785 11 138 9.09E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11035 ddfd97306f89b07a77e35e2e18f95359 145 Gene3D G3DSA:1.10.10.10 11 84 7.0E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS11035 ddfd97306f89b07a77e35e2e18f95359 145 Pfam PF01475 Ferric uptake regulator family 16 131 2.0E-20 T 17-03-2017 IPR002481 Ferric-uptake regulator GO:0003700|GO:0006355 SHXM_RS22580 3b17d231c79425de04b3902aef258b19 266 Pfam PF15698 Phosphatase 13 262 1.6E-113 T 17-03-2017 IPR031423 Uncharacterised phosphatase SCO2771 SHXM_RS50690 4ecf6dc345568c2d0509ab6ddb5c5203 68 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 34 65 1.8E-8 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS34350 1b476ef36a08e7641e10dee7b1f382bc 175 Gene3D G3DSA:3.90.79.10 47 167 5.1E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS34350 1b476ef36a08e7641e10dee7b1f382bc 175 SUPERFAMILY SSF55811 23 168 3.52E-19 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS34350 1b476ef36a08e7641e10dee7b1f382bc 175 Pfam PF00293 NUDIX domain 47 159 3.1E-11 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS09160 9d1b73e88246d346b275b447fede8df6 118 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 47 88 1.4E-8 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS40230 129fadce0759d8ffbd49093adc95bc1b 168 SUPERFAMILY SSF55961 15 160 7.79E-10 T 17-03-2017 SHXM_RS40230 129fadce0759d8ffbd49093adc95bc1b 168 Pfam PF10604 Polyketide cyclase / dehydrase and lipid transport 43 158 2.0E-10 T 17-03-2017 IPR019587 Polyketide cyclase/dehydrase SHXM_RS40230 129fadce0759d8ffbd49093adc95bc1b 168 Gene3D G3DSA:3.30.530.20 47 135 4.0E-7 T 17-03-2017 IPR023393 START-like domain SHXM_RS29225 bb5b5a0cc4b61bc0c4cabccaed97772a 309 Gene3D G3DSA:3.30.530.20 2 138 2.4E-22 T 17-03-2017 IPR023393 START-like domain SHXM_RS29225 bb5b5a0cc4b61bc0c4cabccaed97772a 309 SUPERFAMILY SSF55961 1 135 1.19E-15 T 17-03-2017 SHXM_RS29225 bb5b5a0cc4b61bc0c4cabccaed97772a 309 Pfam PF06240 Carbon monoxide dehydrogenase subunit G (CoxG) 3 134 2.1E-7 T 17-03-2017 IPR010419 Carbon monoxide dehydrogenase subunit G SHXM_RS32945 10719933ca67404a9638dcc0f9a82232 509 Pfam PF13556 PucR C-terminal helix-turn-helix domain 343 397 1.6E-7 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS32945 10719933ca67404a9638dcc0f9a82232 509 Pfam PF13556 PucR C-terminal helix-turn-helix domain 447 505 1.1E-11 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 Gene3D G3DSA:3.40.50.720 156 265 4.5E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 Gene3D G3DSA:3.90.180.10 3 155 5.5E-31 T 17-03-2017 IPR011032 GroES-like SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 SMART SM00829 12 322 4.9E-6 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 SUPERFAMILY SSF50129 294 322 4.72E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 SUPERFAMILY SSF50129 1 123 4.72E-30 T 17-03-2017 IPR011032 GroES-like SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 SUPERFAMILY SSF51735 119 284 6.79E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS40825 ddce5bc9550df618bd0c55df6f171f62 327 Pfam PF00107 Zinc-binding dehydrogenase 157 273 3.0E-11 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS02270 70a676a56782899a397ace7c384563e5 236 SUPERFAMILY SSF51182 99 225 8.27E-20 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS02270 70a676a56782899a397ace7c384563e5 236 Pfam PF07883 Cupin domain 146 214 1.8E-12 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS02270 70a676a56782899a397ace7c384563e5 236 Gene3D G3DSA:2.60.120.10 102 225 3.7E-21 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS25745 1c5dac22cf6a230979301a8f5938b6aa 230 Gene3D G3DSA:1.10.150.240 42 93 9.4E-10 T 17-03-2017 IPR023198 Phosphoglycolate phosphatase, domain 2 SHXM_RS25745 1c5dac22cf6a230979301a8f5938b6aa 230 Pfam PF12710 haloacid dehalogenase-like hydrolase 32 184 1.6E-11 T 17-03-2017 SHXM_RS25745 1c5dac22cf6a230979301a8f5938b6aa 230 SUPERFAMILY SSF56784 30 224 3.22E-34 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS25745 1c5dac22cf6a230979301a8f5938b6aa 230 Gene3D G3DSA:3.40.50.1000 94 223 1.1E-21 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS43460 960dad5b2d5640249b926ed71901c583 451 Gene3D G3DSA:1.10.645.10 7 442 9.4E-78 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS43460 960dad5b2d5640249b926ed71901c583 451 Pfam PF00374 Nickel-dependent hydrogenase 351 442 3.1E-7 T 17-03-2017 IPR001501 Nickel-dependent hydrogenase, large subunit GO:0016151 SHXM_RS43460 960dad5b2d5640249b926ed71901c583 451 Pfam PF00374 Nickel-dependent hydrogenase 44 129 6.6E-10 T 17-03-2017 IPR001501 Nickel-dependent hydrogenase, large subunit GO:0016151 SHXM_RS43460 960dad5b2d5640249b926ed71901c583 451 SUPERFAMILY SSF56762 5 442 1.31E-81 T 17-03-2017 IPR029014 NiFe hydrogenase-like Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS28105 394eaa1d96980a91547a64d560348d43 105 SMART SM01234 1 68 1.1E-40 T 17-03-2017 IPR002696 Putative membrane protein insertion efficiency factor SHXM_RS28105 394eaa1d96980a91547a64d560348d43 105 TIGRFAM TIGR00278 TIGR00278: putative membrane protein insertion efficiency factor 5 73 2.6E-25 T 17-03-2017 IPR002696 Putative membrane protein insertion efficiency factor SHXM_RS28105 394eaa1d96980a91547a64d560348d43 105 Pfam PF01809 Haemolytic domain 5 68 2.7E-27 T 17-03-2017 IPR002696 Putative membrane protein insertion efficiency factor SHXM_RS28105 394eaa1d96980a91547a64d560348d43 105 ProDom PD004225 UPF0161 ALPHA-HEMOLYSIN YIDD UNCHARACTERIZED CYTOSOLIC PRECURSOR SIGNAL YTJA RNPA SIMILAR 16 68 3.0E-25 T 17-03-2017 IPR002696 Putative membrane protein insertion efficiency factor SHXM_RS28105 394eaa1d96980a91547a64d560348d43 105 Hamap MF_00386 Putative membrane protein insertion efficiency factor [yidD]. 1 69 23.466 T 17-03-2017 IPR002696 Putative membrane protein insertion efficiency factor SHXM_RS15140 f4e2098bca30d3eeab50b8d0eb002588 197 SUPERFAMILY SSF100939 10 135 1.14E-13 T 17-03-2017 IPR016194 SPOC-like, C-terminal domain SHXM_RS31005 8bc28754f035603e85f01c87e29d2827 406 SUPERFAMILY SSF51556 13 42 5.27E-77 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31005 8bc28754f035603e85f01c87e29d2827 406 SUPERFAMILY SSF51556 92 402 5.27E-77 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS31005 8bc28754f035603e85f01c87e29d2827 406 Pfam PF04909 Amidohydrolase 101 399 2.1E-45 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS31005 8bc28754f035603e85f01c87e29d2827 406 Gene3D G3DSA:3.20.20.140 14 41 1.1E-72 T 17-03-2017 SHXM_RS31005 8bc28754f035603e85f01c87e29d2827 406 Gene3D G3DSA:3.20.20.140 89 401 1.1E-72 T 17-03-2017 SHXM_RS28240 6dd42f16b79088c0e141f77359daf983 246 Gene3D G3DSA:2.40.260.10 86 233 5.4E-24 T 17-03-2017 IPR023365 Sortase domain SHXM_RS28240 6dd42f16b79088c0e141f77359daf983 246 SUPERFAMILY SSF63817 85 233 1.28E-28 T 17-03-2017 IPR023365 Sortase domain SHXM_RS28240 6dd42f16b79088c0e141f77359daf983 246 TIGRFAM TIGR01076 sortase_fam: sortase 92 228 1.1E-12 T 17-03-2017 IPR005754 Sortase family SHXM_RS28240 6dd42f16b79088c0e141f77359daf983 246 Pfam PF04203 Sortase family 94 229 7.7E-25 T 17-03-2017 IPR005754 Sortase family SHXM_RS00010 9f05da72c299c76936992d81e3db672a 434 SUPERFAMILY SSF103473 11 432 9.81E-88 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS00010 9f05da72c299c76936992d81e3db672a 434 Gene3D G3DSA:1.20.1250.20 242 432 7.7E-24 T 17-03-2017 SHXM_RS00010 9f05da72c299c76936992d81e3db672a 434 Pfam PF07690 Major Facilitator Superfamily 32 393 8.5E-49 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS00010 9f05da72c299c76936992d81e3db672a 434 Gene3D G3DSA:1.20.1250.20 22 224 4.1E-48 T 17-03-2017 SHXM_RS20330 77b560f3b99b1e74846b9ed178af333b 164 Pfam PF11343 Protein of unknown function (DUF3145) 6 162 6.1E-73 T 17-03-2017 IPR021491 Protein of unknown function DUF3145 SHXM_RS20035 fb0d389dd521a0c2d9b07185dbecaf1b 151 Pfam PF05231 MASE1 26 117 1.5E-16 T 17-03-2017 IPR007895 MASE1 SHXM_RS07835 c8c058859d314529c5c88f0d623c72de 423 Pfam PF07158 Dicarboxylate carrier protein MatC N-terminus 1 149 4.5E-64 T 17-03-2017 IPR009827 Dicarboxylate carrier MatC N-terminal SHXM_RS13905 96aa3799fb85d4eafa97572964b6f583 75 SMART SM00704 23 67 1.5E-9 T 17-03-2017 IPR018967 Iron sulphur-containing domain, CDGSH-type GO:0043231|GO:0051537 SHXM_RS13905 96aa3799fb85d4eafa97572964b6f583 75 Pfam PF09360 Iron-binding zinc finger CDGSH type 17 62 1.8E-15 T 17-03-2017 IPR018967 Iron sulphur-containing domain, CDGSH-type GO:0043231|GO:0051537 SHXM_RS20500 7d77e486834c9980b07540aff781270e 213 Pfam PF00132 Bacterial transferase hexapeptide (six repeats) 116 149 2.3E-6 T 17-03-2017 IPR001451 Hexapeptide repeat SHXM_RS20500 7d77e486834c9980b07540aff781270e 213 Gene3D G3DSA:2.160.10.10 59 210 1.1E-44 T 17-03-2017 SHXM_RS20500 7d77e486834c9980b07540aff781270e 213 SUPERFAMILY SSF51161 60 207 7.62E-41 T 17-03-2017 IPR011004 Trimeric LpxA-like SHXM_RS01600 f5b607ed378e7ea5294fd6a716468ce8 260 SUPERFAMILY SSF56281 1 72 1.49E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01600 f5b607ed378e7ea5294fd6a716468ce8 260 SUPERFAMILY SSF56281 109 230 1.49E-24 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01600 f5b607ed378e7ea5294fd6a716468ce8 260 Gene3D G3DSA:3.60.15.10 105 258 1.4E-37 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01600 f5b607ed378e7ea5294fd6a716468ce8 260 Gene3D G3DSA:3.60.15.10 1 68 1.4E-37 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01600 f5b607ed378e7ea5294fd6a716468ce8 260 Pfam PF12706 Beta-lactamase superfamily domain 19 218 5.0E-18 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 Gene3D G3DSA:3.50.50.60 20 69 4.4E-5 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 Gene3D G3DSA:3.50.50.60 86 146 1.9E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 Gene3D G3DSA:3.50.50.60 2 19 1.9E-6 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 SUPERFAMILY SSF51905 3 171 2.64E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 SUPERFAMILY SSF51905 273 388 2.64E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 292 308 6.1E-26 T 17-03-2017 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 150 165 6.1E-26 T 17-03-2017 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 277 292 6.1E-26 T 17-03-2017 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 4 26 6.1E-26 T 17-03-2017 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 SUPERFAMILY SSF54373 174 274 1.37E-40 T 17-03-2017 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 Pfam PF01494 FAD binding domain 3 341 2.9E-74 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS16440 74a10c9e5c1d375df8bf5c88a2f623c6 399 Gene3D G3DSA:3.30.9.10 147 298 5.5E-63 T 17-03-2017 SHXM_RS39385 9cbc9d7fd7ce44530477551448131dfc 185 Pfam PF13671 AAA domain 16 160 1.7E-18 T 17-03-2017 SHXM_RS39385 9cbc9d7fd7ce44530477551448131dfc 185 SUPERFAMILY SSF52540 14 151 1.63E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39385 9cbc9d7fd7ce44530477551448131dfc 185 Gene3D G3DSA:3.40.50.300 14 174 2.7E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS31015 1718d5b4e0304c7783239562ed986901 167 Pfam PF12098 Protein of unknown function (DUF3574) 63 167 6.6E-37 T 17-03-2017 IPR021957 Protein of unknown function DUF3574 SHXM_RS41965 f1d39f0f06b1044aa4c0546614b95c81 165 Pfam PF09933 Predicted small integral membrane protein (DUF2165) 5 152 4.5E-56 T 17-03-2017 IPR018681 Protein of unknown function DUF2165, transmembrane SHXM_RS13460 c6cc9d9efcef1842b187514a04ebe916 252 SUPERFAMILY SSF52096 4 246 3.81E-70 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS13460 c6cc9d9efcef1842b187514a04ebe916 252 Pfam PF00378 Enoyl-CoA hydratase/isomerase 10 246 1.8E-42 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS13460 c6cc9d9efcef1842b187514a04ebe916 252 Gene3D G3DSA:3.90.226.10 4 241 9.4E-66 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS28295 696144273975290e5121d96196a2879a 323 SUPERFAMILY SSF46565 189 229 8.77E-5 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS28295 696144273975290e5121d96196a2879a 323 Gene3D G3DSA:1.10.287.110 189 229 8.6E-5 T 17-03-2017 IPR001623 DnaJ domain SHXM_RS49855 417894b4213d585fc4b8e5a268d025ed 208 SUPERFAMILY SSF159709 19 199 4.45E-46 T 17-03-2017 SHXM_RS49855 417894b4213d585fc4b8e5a268d025ed 208 TIGRFAM TIGR03292 PhnH_redo: phosphonate C-P lyase system protein PhnH 12 197 6.8E-43 T 17-03-2017 IPR008772 Bacterial phosphonate metabolism, PhnH GO:0019634 SHXM_RS49855 417894b4213d585fc4b8e5a268d025ed 208 Pfam PF05845 Bacterial phosphonate metabolism protein (PhnH) 11 198 1.4E-53 T 17-03-2017 IPR008772 Bacterial phosphonate metabolism, PhnH GO:0019634 SHXM_RS49855 417894b4213d585fc4b8e5a268d025ed 208 PIRSF PIRSF020680 3 204 2.5E-51 T 17-03-2017 IPR008772 Bacterial phosphonate metabolism, PhnH GO:0019634 SHXM_RS22395 7b3c0e0a4da3f45de09d0a51aca22459 293 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 107 286 4.4E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22395 7b3c0e0a4da3f45de09d0a51aca22459 293 SUPERFAMILY SSF161098 16 293 3.01E-76 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22395 7b3c0e0a4da3f45de09d0a51aca22459 293 Gene3D G3DSA:1.10.3720.10 15 280 6.0E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04000 016ace680c071fd38a2dbd9451b1e061 278 Pfam PF02673 Bacitracin resistance protein BacA 9 265 1.6E-71 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS04000 016ace680c071fd38a2dbd9451b1e061 278 Hamap MF_01006 Undecaprenyl-diphosphatase [uppP]. 4 271 17.386 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS04000 016ace680c071fd38a2dbd9451b1e061 278 TIGRFAM TIGR00753 undec_PP_bacA: undecaprenyl-diphosphatase UppP 9 264 6.9E-72 T 17-03-2017 IPR003824 Undecaprenyl-diphosphatase UppP GO:0016020|GO:0016311|GO:0050380 KEGG: 00550+3.6.1.27|MetaCyc: PWY-5785 SHXM_RS18725 060b71cb79843ff7a0975779d2faa504 207 Gene3D G3DSA:3.90.420.10 14 196 3.4E-43 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS18725 060b71cb79843ff7a0975779d2faa504 207 Pfam PF00174 Oxidoreductase molybdopterin binding domain 30 178 2.3E-26 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS18725 060b71cb79843ff7a0975779d2faa504 207 SUPERFAMILY SSF56524 12 200 2.49E-51 T 17-03-2017 IPR000572 Oxidoreductase, molybdopterin-binding domain GO:0042128 Reactome: R-HSA-1614517 SHXM_RS42625 153e28327be6c14c7a8650be67ca9bce 172 Gene3D G3DSA:2.70.50.50 31 171 7.5E-31 T 17-03-2017 SHXM_RS42625 153e28327be6c14c7a8650be67ca9bce 172 SUPERFAMILY SSF81296 31 171 1.82E-34 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS42625 153e28327be6c14c7a8650be67ca9bce 172 Pfam PF03067 Lytic polysaccharide mono-oxygenase, cellulose-degrading 31 168 4.2E-16 T 17-03-2017 IPR004302 Chitin-binding protein, N-terminal SHXM_RS07875 c8c6aab194a320c0a7035adf043496eb 152 SUPERFAMILY SSF55729 4 134 1.62E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS07875 c8c6aab194a320c0a7035adf043496eb 152 Pfam PF00583 Acetyltransferase (GNAT) family 56 131 1.9E-13 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS07875 c8c6aab194a320c0a7035adf043496eb 152 Gene3D G3DSA:3.40.630.30 9 133 1.1E-24 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS07400 76643435560fe09ae3b3e76f60e29ce1 378 SUPERFAMILY SSF103481 22 113 4.84E-6 T 17-03-2017 SHXM_RS47400 b8a78cb6265ef9f9801838ba81f26a6c 400 Pfam PF02371 Transposase IS116/IS110/IS902 family 275 357 1.3E-22 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS47400 b8a78cb6265ef9f9801838ba81f26a6c 400 Pfam PF01548 Transposase 11 166 8.1E-44 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS35870 f514bb2858d3ca284e7b73af25ed223b 216 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 72 194 2.1E-22 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS35870 f514bb2858d3ca284e7b73af25ed223b 216 Gene3D G3DSA:3.40.80.10 63 209 2.9E-43 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS35870 f514bb2858d3ca284e7b73af25ed223b 216 SUPERFAMILY SSF55846 62 209 3.93E-42 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS35870 f514bb2858d3ca284e7b73af25ed223b 216 SMART SM00644 62 193 1.9E-41 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS43775 768ac9a0fbfb9f02b804a56806670c9b 120 Gene3D G3DSA:2.102.10.10 2 100 1.0E-31 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS43775 768ac9a0fbfb9f02b804a56806670c9b 120 SUPERFAMILY SSF50022 2 101 1.83E-29 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS43775 768ac9a0fbfb9f02b804a56806670c9b 120 Pfam PF00355 Rieske [2Fe-2S] domain 2 87 1.1E-16 T 17-03-2017 IPR017941 Rieske [2Fe-2S] iron-sulphur domain GO:0016491|GO:0051537|GO:0055114 SHXM_RS27800 1bf78c113e8aea85741f13d50dac8fb0 538 Pfam PF01654 Cytochrome bd terminal oxidase subunit I 10 490 1.7E-173 T 17-03-2017 IPR002585 Cytochrome ubiquinol oxidase subunit 1 GO:0016020 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 95 114 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 253 263 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 325 339 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 301 321 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 285 298 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 138 151 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 PRINTS PR00733 Glycosyl hydrolase family 6 signature 222 235 1.3E-31 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 Gene3D G3DSA:3.20.20.40 75 356 2.6E-86 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 ProSitePatterns PS00656 Glycosyl hydrolases family 6 signature 2. 183 192 - T 17-03-2017 IPR001524 Glycoside hydrolase, family 6, conserved site GO:0004553|GO:0005975 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 Pfam PF01341 Glycosyl hydrolases family 6 88 341 1.5E-63 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS26595 3709571a7111defed36fba6f8676f6fb 357 SUPERFAMILY SSF51989 75 356 3.53E-81 T 17-03-2017 IPR016288 1, 4-beta cellobiohydrolase GO:0004553|GO:0030245 SHXM_RS24620 657b381d94f12267559c96905846338b 232 Pfam PF07510 Protein of unknown function (DUF1524) 81 214 1.5E-17 T 17-03-2017 IPR011089 Domain of unknown function DUF1524 SHXM_RS38595 37284c8ad86599547d9495cca6fbc208 434 SUPERFAMILY SSF53850 34 423 2.61E-61 T 17-03-2017 SHXM_RS38595 37284c8ad86599547d9495cca6fbc208 434 Pfam PF01547 Bacterial extracellular solute-binding protein 55 339 2.5E-35 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS38595 37284c8ad86599547d9495cca6fbc208 434 Gene3D G3DSA:3.40.190.10 33 218 9.0E-37 T 17-03-2017 SHXM_RS28535 2acea3ae59eb9484d55b80d7dc960c8b 313 Gene3D G3DSA:2.60.130.10 57 131 1.3E-50 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS28535 2acea3ae59eb9484d55b80d7dc960c8b 313 Gene3D G3DSA:2.60.130.10 174 280 1.3E-50 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS28535 2acea3ae59eb9484d55b80d7dc960c8b 313 Pfam PF00775 Dioxygenase 74 132 6.9E-7 T 17-03-2017 IPR000627 Intradiol ring-cleavage dioxygenase, C-terminal GO:0003824|GO:0006725|GO:0008199|GO:0055114 SHXM_RS28535 2acea3ae59eb9484d55b80d7dc960c8b 313 SUPERFAMILY SSF49482 174 303 8.24E-45 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS28535 2acea3ae59eb9484d55b80d7dc960c8b 313 SUPERFAMILY SSF49482 56 131 8.24E-45 T 17-03-2017 IPR015889 Intradiol ring-cleavage dioxygenase, core GO:0005506|GO:0016702|GO:0055114 SHXM_RS01715 732368afb60388f71a4efc6b9c7a5c1f 187 SUPERFAMILY SSF52218 1 146 1.39E-42 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS01715 732368afb60388f71a4efc6b9c7a5c1f 187 Gene3D G3DSA:3.40.50.360 2 181 1.9E-55 T 17-03-2017 IPR029039 Flavoprotein-like domain SHXM_RS01715 732368afb60388f71a4efc6b9c7a5c1f 187 Pfam PF03358 NADPH-dependent FMN reductase 2 145 1.7E-40 T 17-03-2017 IPR005025 NADPH-dependent FMN reductase-like GO:0016491 SHXM_RS17495 946c006c5eb834074a8517dfc00a2976 375 Gene3D G3DSA:3.40.50.1820 136 370 3.2E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS17495 946c006c5eb834074a8517dfc00a2976 375 SUPERFAMILY SSF53474 129 371 1.92E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS50045 97e2a379954bfb5832f086d7d2bf7f74 367 Pfam PF14307 Glycosyltransferase WbsX 8 362 9.0E-51 T 17-03-2017 IPR032719 Glycosyltransferase WbsX SHXM_RS09410 d242fa66c0ae195606c7bdb8af33ae43 47 Pfam PF00239 Resolvase, N terminal domain 3 47 1.0E-8 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS09410 d242fa66c0ae195606c7bdb8af33ae43 47 Gene3D G3DSA:3.40.50.1390 1 47 3.7E-11 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS09410 d242fa66c0ae195606c7bdb8af33ae43 47 SUPERFAMILY SSF53041 1 47 5.36E-12 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS15860 1d831aaf1a0f4f5ecd0c9a3dcc9c7ff7 96 Pfam PF02416 mttA/Hcf106 family 5 55 6.1E-18 T 17-03-2017 IPR003369 Sec-independent protein translocase protein TatA/B/E GO:0008565|GO:0015031 SHXM_RS15860 1d831aaf1a0f4f5ecd0c9a3dcc9c7ff7 96 TIGRFAM TIGR01411 tatAE: twin arginine-targeting protein translocase, TatA/E family 5 49 1.0E-17 T 17-03-2017 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SHXM_RS15860 1d831aaf1a0f4f5ecd0c9a3dcc9c7ff7 96 Hamap MF_00236 Sec-independent protein translocase protein TatA [tatA]. 2 76 20.414 T 17-03-2017 IPR006312 Sec-independent protein translocase protein TatA/E GO:0005886|GO:0008565|GO:0009306|GO:0015031|GO:0016021 SHXM_RS43920 980d936d557e6c0f7cc8001126f28602 308 Pfam PF05949 Bacterial protein of unknown function (DUF881) 140 281 2.7E-38 T 17-03-2017 IPR010273 Protein of unknown function DUF881 SHXM_RS00440 d5dd4b0ce28c554a2a40468a7dceb0f3 161 Pfam PF00078 Reverse transcriptase (RNA-dependent DNA polymerase) 55 159 1.6E-17 T 17-03-2017 IPR000477 Reverse transcriptase domain SHXM_RS00440 d5dd4b0ce28c554a2a40468a7dceb0f3 161 SUPERFAMILY SSF56672 14 159 1.56E-24 T 17-03-2017 SHXM_RS43710 f95d3287c62132cd6d1c55870f3e0f17 240 Pfam PF06149 Protein of unknown function (DUF969) 1 217 7.4E-86 T 17-03-2017 IPR010374 Protein of unknown function DUF969 SHXM_RS22775 7f3b723baf7fcc198000bc6a4a9f041a 341 Gene3D G3DSA:1.10.3720.10 48 328 2.0E-58 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22775 7f3b723baf7fcc198000bc6a4a9f041a 341 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 130 339 5.3E-17 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS22775 7f3b723baf7fcc198000bc6a4a9f041a 341 SUPERFAMILY SSF161098 97 326 7.19E-56 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25855 24f6c666e2c7bc06be33b2710a242c02 92 SUPERFAMILY SSF54285 1 91 2.13E-21 T 17-03-2017 IPR016155 Molybdopterin synthase/thiamin biosynthesis sulphur carrier, beta-grasp SHXM_RS25855 24f6c666e2c7bc06be33b2710a242c02 92 Gene3D G3DSA:3.10.20.30 3 89 2.4E-29 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS25855 24f6c666e2c7bc06be33b2710a242c02 92 Pfam PF02597 ThiS family 5 91 5.1E-17 T 17-03-2017 IPR003749 ThiamineS/Molybdopterin converting factor subunit 1 Reactome: R-HSA-947581 SHXM_RS49220 ecaf95f16b8462d147a3fad3e60106bf 409 Pfam PF02371 Transposase IS116/IS110/IS902 family 276 360 8.3E-12 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS49220 ecaf95f16b8462d147a3fad3e60106bf 409 Pfam PF01548 Transposase 4 161 4.7E-34 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS23360 8e1357b664155c2927b7867092f428e6 120 Pfam PF12277 Protein of unknown function (DUF3618) 4 49 2.8E-15 T 17-03-2017 IPR022062 Protein of unknown function DUF3618 SHXM_RS38415 ddc8234cbc7fc58e851f84b3157f30ef 132 Gene3D G3DSA:3.10.450.50 8 108 5.5E-7 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS38415 ddc8234cbc7fc58e851f84b3157f30ef 132 SUPERFAMILY SSF54427 7 114 1.76E-9 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS19710 489cd2a5baacd83afea25cb4be0d0cda 247 Pfam PF02591 C4-type zinc ribbon domain 206 239 1.5E-8 T 17-03-2017 IPR003743 C4-type zinc ribbon domain SHXM_RS11520 c28992e0ea4c26f1dc023d151c6ca3bd 125 Pfam PF13397 RNA polymerase-binding protein 4 107 1.6E-41 T 17-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 SHXM_RS11520 c28992e0ea4c26f1dc023d151c6ca3bd 125 Hamap MF_01483 RNA polymerase-binding protein RbpA [rbpA]. 16 120 26.324 T 17-03-2017 IPR025182 RNA polymerase-binding protein RbpA GO:0001000|GO:0045893 SHXM_RS15045 e9b9000c462f13e7ceba3ac18ad820e6 155 SMART SM00347 33 136 6.6E-13 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS15045 e9b9000c462f13e7ceba3ac18ad820e6 155 Gene3D G3DSA:1.10.10.10 1 153 2.4E-31 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS15045 e9b9000c462f13e7ceba3ac18ad820e6 155 Pfam PF12802 MarR family 38 99 1.6E-10 T 17-03-2017 SHXM_RS15045 e9b9000c462f13e7ceba3ac18ad820e6 155 SUPERFAMILY SSF46785 3 151 2.65E-26 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS20880 31536f4af52f7b3dd68c7bdf938ee783 286 Gene3D G3DSA:3.90.226.10 5 244 1.3E-45 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS20880 31536f4af52f7b3dd68c7bdf938ee783 286 SUPERFAMILY SSF52096 5 256 6.81E-45 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS20880 31536f4af52f7b3dd68c7bdf938ee783 286 Pfam PF00378 Enoyl-CoA hydratase/isomerase 14 255 8.1E-25 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS24500 e2e75340a8af1932c2bfe93f7ca7b982 76 Pfam PF14117 Domain of unknown function (DUF4287) 9 67 1.3E-22 T 17-03-2017 IPR025629 Protein of unknown function DUF4287 SHXM_RS41485 76b6036ea5d512e171792dffd6ea4ce1 228 Pfam PF05988 Bacterial protein of unknown function (DUF899) 7 206 1.2E-59 T 17-03-2017 IPR010296 Protein of unknown function DUF899, thioredoxin-like SHXM_RS41485 76b6036ea5d512e171792dffd6ea4ce1 228 SUPERFAMILY SSF52833 48 173 2.37E-6 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS37295 b330a049b2a633052b56ca4e8f468c77 200 Pfam PF08241 Methyltransferase domain 31 121 1.3E-16 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS37295 b330a049b2a633052b56ca4e8f468c77 200 Gene3D G3DSA:3.40.50.150 18 132 2.0E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS37295 b330a049b2a633052b56ca4e8f468c77 200 SUPERFAMILY SSF53335 11 198 4.91E-32 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS09450 32fa2fd4862709f383811455a5b1e29b 67 Pfam PF01526 Tn3 transposase DDE domain 2 66 1.5E-18 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 TIGRFAM TIGR00711 efflux_EmrB: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family 19 436 1.0E-74 T 17-03-2017 IPR004638 Drug resistance transporter EmrB/QacA subfamily GO:0006810|GO:0016021 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 168 192 7.8E-6 T 17-03-2017 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 21 45 7.8E-6 T 17-03-2017 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 PRINTS PR01036 Tetracycline resistance protein TetB signature 143 167 7.8E-6 T 17-03-2017 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 Pfam PF07690 Major Facilitator Superfamily 23 416 1.6E-52 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 Gene3D G3DSA:1.20.1250.20 271 481 6.2E-15 T 17-03-2017 SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 SUPERFAMILY SSF103473 253 481 2.62E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 SUPERFAMILY SSF103473 7 202 2.62E-64 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS36180 d592026b72310b4dfed7abdb3c425bd7 496 Gene3D G3DSA:1.20.1250.20 8 198 5.4E-28 T 17-03-2017 SHXM_RS46955 2cae3db76235acfc51951c8bd9e442a1 339 Gene3D G3DSA:3.20.20.30 11 336 4.4E-62 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS46955 2cae3db76235acfc51951c8bd9e442a1 339 Pfam PF00296 Luciferase-like monooxygenase 29 294 9.6E-32 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS46955 2cae3db76235acfc51951c8bd9e442a1 339 SUPERFAMILY SSF51679 14 327 1.02E-54 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS11375 2088cf95f6e6d6a4c3023362f0251d4d 359 TIGRFAM TIGR02637 RhaS: rhamnose ABC transporter, rhamnose-binding protein 60 359 2.8E-126 T 17-03-2017 IPR013459 Rhamnose-binding protein GO:0015762 SHXM_RS11375 2088cf95f6e6d6a4c3023362f0251d4d 359 Pfam PF13407 Periplasmic binding protein domain 60 316 1.7E-52 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS11375 2088cf95f6e6d6a4c3023362f0251d4d 359 SUPERFAMILY SSF53822 55 359 1.33E-64 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS11375 2088cf95f6e6d6a4c3023362f0251d4d 359 Gene3D G3DSA:3.40.50.2300 54 175 8.4E-24 T 17-03-2017 SHXM_RS11375 2088cf95f6e6d6a4c3023362f0251d4d 359 Gene3D G3DSA:3.40.50.2300 176 309 4.2E-33 T 17-03-2017 SHXM_RS36800 d44374eafeee9f457554e17589ad549f 300 Gene3D G3DSA:1.20.144.10 95 285 1.5E-20 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS36800 d44374eafeee9f457554e17589ad549f 300 SUPERFAMILY SSF48317 83 284 4.32E-22 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS36800 d44374eafeee9f457554e17589ad549f 300 Pfam PF01569 PAP2 superfamily 206 283 3.1E-11 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS49730 3663e9191379ffb0172a44c157ac9fe4 295 Pfam PF02653 Branched-chain amino acid transport system / permease component 10 285 1.0E-35 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 Pfam PF00072 Response regulator receiver domain 4 115 9.1E-23 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 Pfam PF09339 IclR helix-turn-helix domain 171 206 3.7E-8 T 17-03-2017 IPR005471 Transcription regulator IclR, N-terminal GO:0003677|GO:0006355 SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 SMART SM00448 2 115 2.1E-26 T 17-03-2017 IPR001789 Signal transduction response regulator, receiver domain GO:0000160 SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 SUPERFAMILY SSF46785 176 225 2.97E-7 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 Gene3D G3DSA:3.40.50.2300 1 124 5.3E-29 T 17-03-2017 SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 SUPERFAMILY SSF52172 1 126 4.98E-33 T 17-03-2017 IPR011006 CheY-like superfamily SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 PIRSF PIRSF006171 1 230 2.4E-77 T 17-03-2017 IPR024187 Signal transduction response regulator, citrate/malate metabolism GO:0001071|GO:0003677|GO:0005737|GO:0009605 SHXM_RS03425 7940c5b8f638d560a63ae8a8111743da 230 Gene3D G3DSA:1.10.10.10 170 207 1.8E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 PRINTS PR00359 B-class P450 signature 121 132 1.3E-25 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 PRINTS PR00359 B-class P450 signature 361 370 1.3E-25 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 PRINTS PR00359 B-class P450 signature 167 183 1.3E-25 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 PRINTS PR00359 B-class P450 signature 184 199 1.3E-25 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 PRINTS PR00359 B-class P450 signature 314 341 1.3E-25 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 PRINTS PR00359 B-class P450 signature 218 240 1.3E-25 T 17-03-2017 IPR002397 Cytochrome P450, B-class GO:0005506|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 Gene3D G3DSA:1.10.630.10 22 425 2.5E-94 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 SUPERFAMILY SSF48264 21 424 1.09E-67 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS08415 6cf1a5739fd6d44892f18a67dfda546b 486 ProSitePatterns PS00086 Cytochrome P450 cysteine heme-iron ligand signature. 363 372 - T 17-03-2017 IPR017972 Cytochrome P450, conserved site GO:0016705|GO:0055114 SHXM_RS03810 3796b585cc345d221587dd34d8751094 312 TIGRFAM TIGR04187 GRASP_SAV_5884: ATP-grasp ribosomal peptide maturase, SAV_5884 family 2 304 1.7E-111 T 17-03-2017 IPR026449 ATP-grasp ribosomal peptide maturase, SAV_5884 family SHXM_RS03810 3796b585cc345d221587dd34d8751094 312 SUPERFAMILY SSF56059 128 304 3.53E-19 T 17-03-2017 SHXM_RS42925 915cc13eaf89a8698ceb12e8f450e33f 253 Pfam PF09490 Probable cobalt transporter subunit (CbtA) 7 231 4.9E-67 T 17-03-2017 IPR012666 Cobalt transporter subunit CbtA, putative SHXM_RS37455 4fee3403bcdd92c8d8c8707517826eaa 730 Pfam PF00005 ABC transporter 20 156 8.7E-19 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS37455 4fee3403bcdd92c8d8c8707517826eaa 730 SMART SM00382 28 205 2.9E-4 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS37455 4fee3403bcdd92c8d8c8707517826eaa 730 SUPERFAMILY SSF52540 2 218 1.2E-39 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37455 4fee3403bcdd92c8d8c8707517826eaa 730 Gene3D G3DSA:3.40.50.300 1 221 4.3E-42 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS39250 353239a6ca4daccc2c7632caebc960c8 131 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 6 121 1.2E-15 T 17-03-2017 IPR018727 Protein of unknown function DUF2267 SHXM_RS48960 52c6fc30c96f0db125a80a8bc59b581c 278 Pfam PF13586 Transposase DDE domain 186 261 2.7E-13 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS48960 52c6fc30c96f0db125a80a8bc59b581c 278 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 11 90 5.9E-25 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS09145 ab95ae6cce66aa4d324eb2933b8b2529 408 Pfam PF01548 Transposase 4 161 1.5E-32 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS09145 ab95ae6cce66aa4d324eb2933b8b2529 408 Pfam PF02371 Transposase IS116/IS110/IS902 family 274 359 2.0E-17 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS36690 fc758b3b3edd6ad2a834ed5ae5beaa4e 537 Gene3D G3DSA:1.10.3720.10 277 532 1.9E-43 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36690 fc758b3b3edd6ad2a834ed5ae5beaa4e 537 Gene3D G3DSA:1.10.3720.10 2 254 1.2E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36690 fc758b3b3edd6ad2a834ed5ae5beaa4e 537 SUPERFAMILY SSF161098 271 531 3.27E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36690 fc758b3b3edd6ad2a834ed5ae5beaa4e 537 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 67 252 9.6E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36690 fc758b3b3edd6ad2a834ed5ae5beaa4e 537 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 351 523 1.3E-9 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS36690 fc758b3b3edd6ad2a834ed5ae5beaa4e 537 SUPERFAMILY SSF161098 2 248 2.62E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15925 18348f7688a50f1c18d8247bb071287f 503 TIGRFAM TIGR03688 pupylate_PafA2: proteasome accessory factor PafA2 4 490 1.8E-243 T 17-03-2017 IPR022366 Pup deamidase GO:0008233|GO:0016811 SHXM_RS15925 18348f7688a50f1c18d8247bb071287f 503 Pfam PF03136 Pup-ligase protein 5 457 6.1E-191 T 17-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 SHXM_RS15925 18348f7688a50f1c18d8247bb071287f 503 PIRSF PIRSF018077 10 500 4.4E-217 T 17-03-2017 IPR004347 Pup ligase/deamidase GO:0010498|GO:0019941 SHXM_RS28315 ccbbf755f3f6db4c4216040ca09d6203 179 TIGRFAM TIGR02159 PA_CoA_Oxy4: phenylacetate-CoA oxygenase, PaaJ subunit 31 178 4.0E-53 T 17-03-2017 IPR011883 Phenylacetate-CoA oxygenase, PaaJ subunit SHXM_RS28315 ccbbf755f3f6db4c4216040ca09d6203 179 Pfam PF01883 Domain of unknown function DUF59 29 96 1.9E-11 T 17-03-2017 IPR002744 Domain of unknown function DUF59 SHXM_RS28315 ccbbf755f3f6db4c4216040ca09d6203 179 SUPERFAMILY SSF117916 19 114 6.21E-20 T 17-03-2017 SHXM_RS16110 cd5fdeefb55c7f775b247d459e0a69a4 308 Pfam PF01391 Collagen triple helix repeat (20 copies) 179 236 2.1E-6 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS16110 cd5fdeefb55c7f775b247d459e0a69a4 308 Pfam PF01391 Collagen triple helix repeat (20 copies) 154 210 4.4E-10 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS16110 cd5fdeefb55c7f775b247d459e0a69a4 308 Pfam PF03777 Small secreted domain (DUF320) 26 78 1.1E-19 T 17-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species SHXM_RS16110 cd5fdeefb55c7f775b247d459e0a69a4 308 Pfam PF03777 Small secreted domain (DUF320) 90 144 7.8E-17 T 17-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species SHXM_RS05540 e4280f1ee21d149b76c6b7ae3c34d4c8 386 Gene3D G3DSA:3.30.565.10 292 378 6.8E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05540 e4280f1ee21d149b76c6b7ae3c34d4c8 386 SUPERFAMILY SSF55874 269 377 1.43E-16 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05540 e4280f1ee21d149b76c6b7ae3c34d4c8 386 Pfam PF07730 Histidine kinase 178 244 1.0E-16 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS05540 e4280f1ee21d149b76c6b7ae3c34d4c8 386 SMART SM00387 288 380 1.5E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS00190 9560d3293960cb6a3bcef22a1ca431cc 190 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 12 25 3.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS00190 9560d3293960cb6a3bcef22a1ca431cc 190 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 33 56 3.4E-7 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS00190 9560d3293960cb6a3bcef22a1ca431cc 190 Pfam PF00440 Bacterial regulatory proteins, tetR family 15 57 1.1E-14 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS00190 9560d3293960cb6a3bcef22a1ca431cc 190 Gene3D G3DSA:1.10.10.60 11 54 2.5E-16 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS00190 9560d3293960cb6a3bcef22a1ca431cc 190 Gene3D G3DSA:1.10.357.10 55 181 7.3E-14 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS00190 9560d3293960cb6a3bcef22a1ca431cc 190 SUPERFAMILY SSF46689 8 63 2.13E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS13565 f23a3ab477c95e079e7b70cc78d977bf 360 SUPERFAMILY SSF110296 46 324 7.06E-37 T 17-03-2017 SHXM_RS13565 f23a3ab477c95e079e7b70cc78d977bf 360 Gene3D G3DSA:2.130.10.140 58 333 2.0E-32 T 17-03-2017 SHXM_RS40130 0de3e4e7a1ee33f8467a3bb2f2d06119 267 Gene3D G3DSA:3.40.50.880 77 236 8.5E-14 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS40130 0de3e4e7a1ee33f8467a3bb2f2d06119 267 SUPERFAMILY SSF52317 61 241 7.77E-14 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS40130 0de3e4e7a1ee33f8467a3bb2f2d06119 267 Pfam PF09825 Biotin-protein ligase, N terminal 51 150 8.1E-7 T 17-03-2017 IPR019197 Biotin-protein ligase, N-terminal Reactome: R-HSA-196780|Reactome: R-HSA-3371599 SHXM_RS40255 b677716387e5d649f908ab47f1a867cf 155 Gene3D G3DSA:2.60.120.10 17 152 6.2E-33 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS40255 b677716387e5d649f908ab47f1a867cf 155 SUPERFAMILY SSF51182 9 127 1.19E-23 T 17-03-2017 IPR011051 RmlC-like cupin domain SHXM_RS40255 b677716387e5d649f908ab47f1a867cf 155 Pfam PF07883 Cupin domain 40 106 4.9E-15 T 17-03-2017 IPR013096 Cupin 2, conserved barrel SHXM_RS45425 550da26a4e068de8b56694273d818639 426 Pfam PF04143 Sulphur transport 77 406 8.5E-62 T 17-03-2017 IPR007272 Sulphur transport domain SHXM_RS43725 15197e95575a86c04b0f73c42f3b9ebe 327 Pfam PF11199 Protein of unknown function (DUF2891) 2 318 1.0E-124 T 17-03-2017 IPR021365 Protein of unknown function DUF2891 SHXM_RS04580 511db9cb0296de269692915d41ee115d 371 PIRSF PIRSF000138 1 355 2.5E-123 T 17-03-2017 IPR012133 Alpha-hydroxy acid dehydrogenase, FMN-dependent GO:0010181|GO:0016491|GO:0055114 SHXM_RS04580 511db9cb0296de269692915d41ee115d 371 Gene3D G3DSA:3.20.20.70 2 352 3.9E-131 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS04580 511db9cb0296de269692915d41ee115d 371 ProSitePatterns PS00557 FMN-dependent alpha-hydroxy acid dehydrogenases active site. 249 255 - T 17-03-2017 IPR008259 FMN-dependent alpha-hydroxy acid dehydrogenase, active site GO:0016491|GO:0055114 SHXM_RS04580 511db9cb0296de269692915d41ee115d 371 Pfam PF01070 FMN-dependent dehydrogenase 11 352 4.1E-122 T 17-03-2017 IPR000262 FMN-dependent dehydrogenase GO:0016491 SHXM_RS04580 511db9cb0296de269692915d41ee115d 371 SUPERFAMILY SSF51395 2 351 2.99E-93 T 17-03-2017 SHXM_RS04205 c20c790cc18a2f161286976655346ac8 268 SUPERFAMILY SSF51230 63 135 1.86E-6 T 17-03-2017 IPR011053 Single hybrid motif SHXM_RS04205 c20c790cc18a2f161286976655346ac8 268 Pfam PF13437 HlyD family secretion protein 107 195 4.1E-8 T 17-03-2017 SHXM_RS04205 c20c790cc18a2f161286976655346ac8 268 Gene3D G3DSA:2.40.50.100 65 136 2.8E-7 T 17-03-2017 SHXM_RS27305 7cecb2464131a5d3a6eb756778b2ed7e 233 Pfam PF13399 LytR cell envelope-related transcriptional attenuator 114 204 2.3E-15 T 17-03-2017 IPR027381 Putative LytR/CpsA/Psr regulator, C-terminal domain SHXM_RS09300 63fc13640d8a1b2b5568c04a2fffe723 141 Pfam PF08388 Group II intron, maturase-specific domain 2 76 7.9E-19 T 17-03-2017 IPR013597 Group II intron, maturase-specific SHXM_RS27760 7158d3f42b31273daabf0755f9e483eb 302 Hamap MF_00188 Protease HtpX [htpX]. 8 292 25.423 T 17-03-2017 IPR022919 Peptidase M48, protease HtpX, putative GO:0004222 SHXM_RS27760 7158d3f42b31273daabf0755f9e483eb 302 Gene3D G3DSA:3.30.2010.10 68 159 2.9E-33 T 17-03-2017 SHXM_RS27760 7158d3f42b31273daabf0755f9e483eb 302 Pfam PF01435 Peptidase family M48 75 291 9.6E-35 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS04945 c0e8e28180b5b0228a80a17d5ea37ac6 323 Pfam PF07730 Histidine kinase 87 154 1.2E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS04945 c0e8e28180b5b0228a80a17d5ea37ac6 323 SUPERFAMILY SSF55874 164 293 4.28E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS04945 c0e8e28180b5b0228a80a17d5ea37ac6 323 Gene3D G3DSA:3.30.565.10 166 295 1.0E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS04945 c0e8e28180b5b0228a80a17d5ea37ac6 323 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 194 293 1.0E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS48260 cd3adfb034c85a7fd92a56a57da548b8 186 Pfam PF06821 Serine hydrolase 9 182 2.5E-42 T 17-03-2017 IPR010662 Putative hydrolase RBBP9/YdeN GO:0016787 SHXM_RS48260 cd3adfb034c85a7fd92a56a57da548b8 186 Gene3D G3DSA:3.40.50.1820 6 185 4.3E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS48260 cd3adfb034c85a7fd92a56a57da548b8 186 SUPERFAMILY SSF53474 7 182 2.39E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS16825 23d82ccac34df078ab331a127312e4ab 620 Pfam PF06276 Ferric iron reductase FhuF-like transporter 418 578 1.2E-34 T 17-03-2017 IPR022770 Ferric iron reductase FhuF domain SHXM_RS16825 23d82ccac34df078ab331a127312e4ab 620 Pfam PF04183 IucA / IucC family 149 394 3.5E-52 T 17-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 SHXM_RS46765 ca8fed64de4369054f21cdcdb968b05f 173 Gene3D G3DSA:3.40.630.30 21 165 3.1E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS46765 ca8fed64de4369054f21cdcdb968b05f 173 Pfam PF00583 Acetyltransferase (GNAT) family 67 144 3.9E-5 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS46765 ca8fed64de4369054f21cdcdb968b05f 173 SUPERFAMILY SSF55729 22 152 1.75E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33505 f76a093868531b8eafec4a05ebdf6a89 154 Pfam PF02643 Uncharacterized ACR, COG1430 48 140 2.3E-14 T 17-03-2017 IPR003795 Protein of unknown function DUF192 SHXM_RS20355 42f89fdea4aca8c1b8a670610c3c5985 409 Gene3D G3DSA:1.20.1250.20 242 388 2.5E-8 T 17-03-2017 SHXM_RS20355 42f89fdea4aca8c1b8a670610c3c5985 409 Gene3D G3DSA:1.20.1250.20 5 197 2.7E-10 T 17-03-2017 SHXM_RS20355 42f89fdea4aca8c1b8a670610c3c5985 409 SUPERFAMILY SSF103473 13 380 9.29E-27 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS47945 2b5a7877f5d6a0a682921710a8b57638 525 Gene3D G3DSA:3.40.605.10 16 258 9.6E-49 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS47945 2b5a7877f5d6a0a682921710a8b57638 525 Pfam PF00171 Aldehyde dehydrogenase family 18 453 6.9E-49 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS47945 2b5a7877f5d6a0a682921710a8b57638 525 Gene3D G3DSA:3.40.309.10 268 453 3.1E-41 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS47945 2b5a7877f5d6a0a682921710a8b57638 525 SUPERFAMILY SSF53720 19 519 1.83E-94 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS32920 d4a9caf3c386cc2868c340468c0f304f 89 Pfam PF05120 Gas vesicle protein G 8 75 1.1E-23 T 17-03-2017 IPR007804 Gas vesicle protein GvpG SHXM_RS43935 a7a14a9521c8986ab0e281c1326d5348 255 Pfam PF13240 zinc-ribbon domain 80 101 1.9E-6 T 17-03-2017 IPR026870 Zinc-ribbon domain SHXM_RS43935 a7a14a9521c8986ab0e281c1326d5348 255 Pfam PF00498 FHA domain 176 240 4.0E-18 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS43935 a7a14a9521c8986ab0e281c1326d5348 255 Gene3D G3DSA:2.60.200.20 151 247 2.2E-29 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS43935 a7a14a9521c8986ab0e281c1326d5348 255 SMART SM00240 174 225 5.1E-12 T 17-03-2017 IPR000253 Forkhead-associated (FHA) domain GO:0005515 SHXM_RS43935 a7a14a9521c8986ab0e281c1326d5348 255 SUPERFAMILY SSF49879 136 247 3.63E-30 T 17-03-2017 IPR008984 SMAD/FHA domain GO:0005515 SHXM_RS14015 c3f81e3e38715adae0eecfde807b143b 415 Gene3D G3DSA:1.10.1780.10 145 293 8.6E-6 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS14015 c3f81e3e38715adae0eecfde807b143b 415 Gene3D G3DSA:1.10.1780.10 346 410 4.7E-4 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS14780 8077839028c59d30380021a770b8f96d 358 Pfam PF03747 ADP-ribosylglycohydrolase 14 320 4.3E-51 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS14780 8077839028c59d30380021a770b8f96d 358 SUPERFAMILY SSF101478 8 350 3.27E-40 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS48460 891b07a9d5a875f3be89482021d5b71b 289 Pfam PF16640 Bacterial Ig-like domain (group 3) 13 98 1.8E-15 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS48460 891b07a9d5a875f3be89482021d5b71b 289 Pfam PF16640 Bacterial Ig-like domain (group 3) 198 279 2.6E-10 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS07945 eb2a9927a8578d81b624834aa436b317 150 Hamap MF_00576 Gas vesicle structural protein [gvpA]. 8 93 24.235 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS07945 eb2a9927a8578d81b624834aa436b317 150 Pfam PF00741 Gas vesicle protein 19 57 2.9E-12 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS07945 eb2a9927a8578d81b624834aa436b317 150 ProSitePatterns PS00669 Gas vesicles protein GVPa signature 2. 53 66 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS07945 eb2a9927a8578d81b624834aa436b317 150 ProSitePatterns PS00234 Gas vesicles protein GVPa signature 1. 20 34 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS40160 b7c08735ef511cea2860cfaf91547510 272 SUPERFAMILY SSF55811 112 253 3.38E-17 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS40160 b7c08735ef511cea2860cfaf91547510 272 Pfam PF00293 NUDIX domain 124 186 3.1E-9 T 17-03-2017 IPR000086 NUDIX hydrolase domain GO:0016787 SHXM_RS40160 b7c08735ef511cea2860cfaf91547510 272 SUPERFAMILY SSF88697 3 105 1.42E-14 T 17-03-2017 IPR015947 PUA-like domain SHXM_RS40160 b7c08735ef511cea2860cfaf91547510 272 Gene3D G3DSA:3.10.480.10 3 103 7.6E-21 T 17-03-2017 SHXM_RS40160 b7c08735ef511cea2860cfaf91547510 272 Gene3D G3DSA:3.90.79.10 123 250 3.2E-13 T 17-03-2017 IPR015797 NUDIX hydrolase domain-like GO:0016787 SHXM_RS27745 2539a73e2f10ef35caf7badea5edf561 359 Gene3D G3DSA:3.40.50.300 10 235 3.2E-61 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27745 2539a73e2f10ef35caf7badea5edf561 359 SUPERFAMILY SSF52540 18 221 5.52E-55 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS27745 2539a73e2f10ef35caf7badea5edf561 359 Pfam PF00005 ABC transporter 28 171 1.4E-26 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS27745 2539a73e2f10ef35caf7badea5edf561 359 SMART SM00382 36 219 3.9E-12 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS02615 1b84e239943b1e20e2f4d854288f08ab 89 Pfam PF11512 Agrobacterium tumefaciens protein Atu4866 12 84 2.4E-37 T 17-03-2017 IPR020955 Uncharacterised protein family Atu4866 SHXM_RS40605 8d6b3f5dd595a663dff71fca21470fe9 234 Pfam PF02517 CAAX protease self-immunity 140 224 2.1E-17 T 17-03-2017 IPR003675 CAAX amino terminal protease GO:0016020 SHXM_RS43090 fe759f79b9ad9573a9ec3ec3e58e9b3b 185 Gene3D G3DSA:3.40.630.30 14 165 4.6E-29 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS43090 fe759f79b9ad9573a9ec3ec3e58e9b3b 185 SUPERFAMILY SSF55729 15 164 4.8E-27 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS43090 fe759f79b9ad9573a9ec3ec3e58e9b3b 185 Pfam PF13673 Acetyltransferase (GNAT) domain 57 157 6.8E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS40090 0cc0dad2fe8dcf39e66d68b9b79450bd 168 Pfam PF01526 Tn3 transposase DDE domain 58 167 3.3E-30 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS27660 372e680fe91cd2d8b144ad84c95e51e2 220 SUPERFAMILY SSF52833 55 216 8.55E-35 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS27660 372e680fe91cd2d8b144ad84c95e51e2 220 Gene3D G3DSA:3.40.30.10 10 217 2.5E-43 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS27660 372e680fe91cd2d8b144ad84c95e51e2 220 Pfam PF02630 SCO1/SenC 53 181 1.2E-23 T 17-03-2017 IPR003782 Copper chaperone SCO1/SenC Reactome: R-HSA-5628897|Reactome: R-HSA-611105 SHXM_RS43990 34b02d9e76604bf441aa03020abfaeb3 265 Pfam PF02517 CAAX protease self-immunity 158 246 1.3E-13 T 17-03-2017 IPR003675 CAAX amino terminal protease GO:0016020 SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 Pfam PF00107 Zinc-binding dehydrogenase 153 286 4.6E-19 T 17-03-2017 IPR013149 Alcohol dehydrogenase, C-terminal GO:0055114 SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 SUPERFAMILY SSF50129 7 130 8.38E-29 T 17-03-2017 IPR011032 GroES-like SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 Gene3D G3DSA:3.40.50.720 136 296 1.1E-57 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 Pfam PF16884 N-terminal domain of oxidoreductase 10 104 2.2E-25 T 17-03-2017 SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 SMART SM00829 38 327 6.6E-7 T 17-03-2017 IPR020843 Polyketide synthase, enoylreductase domain GO:0016491 SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 Gene3D G3DSA:3.90.180.10 7 135 9.8E-39 T 17-03-2017 IPR011032 GroES-like SHXM_RS09650 3e44f8a3ef8e5d8bbb2761be953e53ee 331 SUPERFAMILY SSF51735 119 295 1.74E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS50115 1c838ff22a8c4e03789626e091877a1c 137 Gene3D G3DSA:3.10.129.10 9 135 1.4E-29 T 17-03-2017 IPR029069 HotDog domain SHXM_RS50115 1c838ff22a8c4e03789626e091877a1c 137 SUPERFAMILY SSF54637 12 132 1.21E-32 T 17-03-2017 IPR029069 HotDog domain SHXM_RS50115 1c838ff22a8c4e03789626e091877a1c 137 PIRSF PIRSF014972 10 137 5.8E-29 T 17-03-2017 IPR025540 Fluoroacetyl-CoA thioesterase SHXM_RS15710 f1a177836e4efa411722311e24e5fff2 326 SUPERFAMILY SSF53686 9 316 2.1E-73 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS15710 f1a177836e4efa411722311e24e5fff2 326 Pfam PF00291 Pyridoxal-phosphate dependent enzyme 22 306 1.7E-67 T 17-03-2017 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzyme SHXM_RS15710 f1a177836e4efa411722311e24e5fff2 326 Gene3D G3DSA:3.40.50.1100 73 316 1.6E-53 T 17-03-2017 SHXM_RS14960 fc6df09a02163aa671dfbfc7a517cb09 375 Pfam PF07730 Histidine kinase 187 250 3.6E-12 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS11280 39ec088decc7ba87db75bedc8ed0af01 373 SUPERFAMILY SSF53335 45 178 7.45E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS11280 39ec088decc7ba87db75bedc8ed0af01 373 Pfam PF06325 Ribosomal protein L11 methyltransferase (PrmA) 66 146 3.0E-8 T 17-03-2017 SHXM_RS11280 39ec088decc7ba87db75bedc8ed0af01 373 Gene3D G3DSA:3.40.50.150 44 173 1.4E-25 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24705 f3ca2340498ed7dd44c12500d4581b2a 392 Pfam PF00756 Putative esterase 143 376 2.8E-14 T 17-03-2017 IPR000801 Putative esterase Reactome: R-HSA-156590 SHXM_RS24705 f3ca2340498ed7dd44c12500d4581b2a 392 SUPERFAMILY SSF53474 123 382 1.83E-25 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS24705 f3ca2340498ed7dd44c12500d4581b2a 392 Gene3D G3DSA:3.40.50.1820 122 383 6.3E-36 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47760 97296698b373614e116ff76e13d0e208 930 Gene3D G3DSA:2.60.120.260 771 881 9.6E-5 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS47760 97296698b373614e116ff76e13d0e208 930 SUPERFAMILY SSF49785 772 882 1.42E-7 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS47300 6165ac2bc93ae5ad5b1550956b1af7cf 269 SUPERFAMILY SSF88713 4 254 2.89E-80 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS47300 6165ac2bc93ae5ad5b1550956b1af7cf 269 Pfam PF03746 LamB/YcsF family 5 246 3.0E-84 T 17-03-2017 IPR005501 Uncharacterised protein family UPF0271, LamB/YcsF SHXM_RS14745 e634a83604eac9cdd0aa0f4ced2809d0 168 SUPERFAMILY SSF54637 2 148 1.87E-43 T 17-03-2017 IPR029069 HotDog domain SHXM_RS14745 e634a83604eac9cdd0aa0f4ced2809d0 168 Gene3D G3DSA:3.10.129.10 2 148 1.3E-41 T 17-03-2017 IPR029069 HotDog domain SHXM_RS14745 e634a83604eac9cdd0aa0f4ced2809d0 168 Pfam PF01575 MaoC like domain 12 126 5.7E-16 T 17-03-2017 IPR002539 MaoC-like domain SHXM_RS09630 ab08f717184954c0f05c163f2ebd5436 74 Pfam PF13359 DDE superfamily endonuclease 1 72 1.6E-12 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS27850 d3a3e77fbb5ae17b0f62648242c1c21b 64 ProDom PD267558 MEMBRANE TRANSMEMBRANE SPANNING SCO3924 4 62 1.0E-8 T 17-03-2017 IPR020246 Uncharacterised protein family SCO3924 SHXM_RS20810 f262ac19618efa61355f77378005468f 282 Gene3D G3DSA:1.10.260.40 3 70 3.1E-13 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS20810 f262ac19618efa61355f77378005468f 282 Pfam PF13560 Helix-turn-helix domain 11 71 5.4E-11 T 17-03-2017 SHXM_RS20810 f262ac19618efa61355f77378005468f 282 SUPERFAMILY SSF47413 4 68 9.48E-7 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS30970 9b131cfde2a59f7450ec46398f2d0d31 519 Pfam PF00361 Proton-conducting membrane transporter 141 443 3.6E-51 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30970 9b131cfde2a59f7450ec46398f2d0d31 519 Hamap MF_00445 NAD(P)H-quinone oxidoreductase subunit 2, chloroplastic [ndhB]. 16 511 14.878 T 17-03-2017 IPR010096 NAD(P)H-quinone oxidoreductase, subunit N/subunit 2 GO:0008137|GO:0042773|GO:0055114 SHXM_RS34685 e083cc0c245be4dea5d063c4beec1328 219 Gene3D G3DSA:3.40.50.1000 90 139 7.2E-6 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS34685 e083cc0c245be4dea5d063c4beec1328 219 SUPERFAMILY SSF56784 85 204 2.23E-11 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS34685 e083cc0c245be4dea5d063c4beec1328 219 Pfam PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) 34 106 7.4E-7 T 17-03-2017 IPR005519 Acid phosphatase, class B-like SHXM_RS34685 e083cc0c245be4dea5d063c4beec1328 219 Pfam PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) 112 214 7.1E-19 T 17-03-2017 IPR005519 Acid phosphatase, class B-like SHXM_RS03445 46b9c27bb98b91e3ecbbaa33fc98c492 681 Gene3D G3DSA:3.40.50.150 268 417 6.2E-28 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03445 46b9c27bb98b91e3ecbbaa33fc98c492 681 SUPERFAMILY SSF53335 267 415 2.6E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS03445 46b9c27bb98b91e3ecbbaa33fc98c492 681 Pfam PF01564 Spermine/spermidine synthase 268 386 2.4E-7 T 17-03-2017 SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 Gene3D G3DSA:2.10.109.10 200 254 4.9E-40 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 Gene3D G3DSA:2.10.109.10 69 162 4.9E-40 T 17-03-2017 IPR028360 Peptidase S24/S26, beta-ribbon domain SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 Pfam PF10502 Signal peptidase, peptidase S26 152 240 4.8E-6 T 17-03-2017 IPR019533 Peptidase S26 SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 ProSitePatterns PS00761 Signal peptidases I signature 3. 205 218 - T 17-03-2017 IPR019758 Peptidase S26A, signal peptidase I, conserved site GO:0008236|GO:0016021 SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 SUPERFAMILY SSF51306 72 119 1.71E-48 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 SUPERFAMILY SSF51306 147 252 1.71E-48 T 17-03-2017 IPR015927 Peptidase S24/S26A/S26B/S26C SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 Pfam PF00717 Peptidase S24-like 79 117 4.3E-10 T 17-03-2017 IPR019759 Peptidase S24/S26A/S26B SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 72 88 1.9E-21 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 152 164 1.9E-21 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 PRINTS PR00727 Bacterial leader peptidase 1 (S26A) family signature 200 219 1.9E-21 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS36595 1d88269b8adb786d2974a720f9fb2108 278 TIGRFAM TIGR02227 sigpep_I_bact: signal peptidase I 60 246 3.4E-38 T 17-03-2017 IPR000223 Peptidase S26A, signal peptidase I GO:0006508|GO:0008236|GO:0016020 SHXM_RS41720 aa6c6f92d5d4f038563036db39e3cacb 466 Gene3D G3DSA:2.130.10.10 195 438 7.5E-22 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS41720 aa6c6f92d5d4f038563036db39e3cacb 466 SUPERFAMILY SSF82171 197 259 9.42E-23 T 17-03-2017 SHXM_RS41720 aa6c6f92d5d4f038563036db39e3cacb 466 SUPERFAMILY SSF82171 297 442 9.42E-23 T 17-03-2017 SHXM_RS05120 d90bc969adf6fb13814bacea7a1c51be 103 SUPERFAMILY SSF48264 2 75 1.31E-14 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS05120 d90bc969adf6fb13814bacea7a1c51be 103 Gene3D G3DSA:1.10.630.10 1 75 7.3E-17 T 17-03-2017 IPR001128 Cytochrome P450 GO:0005506|GO:0016705|GO:0020037|GO:0055114 SHXM_RS02445 a392eeb1eb7a8c6e66a960a1d48aae47 307 Pfam PF01738 Dienelactone hydrolase family 16 133 1.4E-7 T 17-03-2017 IPR002925 Dienelactone hydrolase GO:0016787 SHXM_RS02445 a392eeb1eb7a8c6e66a960a1d48aae47 307 SUPERFAMILY SSF53474 196 305 7.23E-44 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02445 a392eeb1eb7a8c6e66a960a1d48aae47 307 SUPERFAMILY SSF53474 6 139 7.23E-44 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS02445 a392eeb1eb7a8c6e66a960a1d48aae47 307 Gene3D G3DSA:3.40.50.1820 5 306 5.3E-60 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS23220 85835a2416137c8a7a35ddd820799789 175 Pfam PF06736 Protein of unknown function (DUF1211) 11 100 1.1E-25 T 17-03-2017 IPR010617 Endosomal/lysomomal potassium channel TMEM175 GO:0005267 SHXM_RS48365 74e76ee22dc6bf425eab8e5d08034541 800 Pfam PF05345 Putative Ig domain 749 787 1.0E-6 T 17-03-2017 IPR008009 Putative Ig SHXM_RS48365 74e76ee22dc6bf425eab8e5d08034541 800 Gene3D G3DSA:2.60.40.10 733 798 2.1E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS24870 0149c4dcfed27d87e5b650a45c52a4bb 362 Pfam PF01135 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) 10 238 1.1E-30 T 17-03-2017 SHXM_RS24870 0149c4dcfed27d87e5b650a45c52a4bb 362 Gene3D G3DSA:3.40.50.150 19 244 1.1E-54 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24870 0149c4dcfed27d87e5b650a45c52a4bb 362 SUPERFAMILY SSF53335 23 60 3.27E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24870 0149c4dcfed27d87e5b650a45c52a4bb 362 SUPERFAMILY SSF53335 88 202 3.27E-29 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24870 0149c4dcfed27d87e5b650a45c52a4bb 362 ProSitePatterns PS01279 Protein-L-isoaspartate(D-aspartate) O-methyltransferase signature. 161 176 - T 17-03-2017 IPR000682 Protein-L-isoaspartate(D-aspartate) O-methyltransferase GO:0004719|GO:0006464 SHXM_RS05490 2a1b933df1cb852fbfd477981c582465 218 Pfam PF04264 YceI-like domain 44 210 1.2E-42 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS05490 2a1b933df1cb852fbfd477981c582465 218 SUPERFAMILY SSF101874 42 213 1.14E-53 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS05490 2a1b933df1cb852fbfd477981c582465 218 Gene3D G3DSA:2.40.128.110 43 213 3.9E-56 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS05490 2a1b933df1cb852fbfd477981c582465 218 SMART SM00867 43 212 1.4E-62 T 17-03-2017 IPR007372 Lipid/polyisoprenoid-binding, YceI-like SHXM_RS39160 71add55c2ce210f0a4b7f937a9daf9da 279 Pfam PF00941 FAD binding domain in molybdopterin dehydrogenase 27 171 1.9E-17 T 17-03-2017 IPR002346 Molybdopterin dehydrogenase, FAD-binding GO:0016491|GO:0055114 SHXM_RS39160 71add55c2ce210f0a4b7f937a9daf9da 279 SUPERFAMILY SSF56176 22 171 6.0E-27 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS39160 71add55c2ce210f0a4b7f937a9daf9da 279 Gene3D G3DSA:3.30.465.10 57 171 1.7E-21 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS25525 618837592d22bd1d26ed694d244ffc9b 221 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 28 201 1.7E-24 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS25525 618837592d22bd1d26ed694d244ffc9b 221 SMART SM00943 28 209 3.1E-30 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS21730 5a247c427972fda23e3d219863cee2b6 394 Pfam PF01757 Acyltransferase family 54 358 5.1E-23 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS36280 f89bf351dc723970a4e1cfdb137535a8 194 Gene3D G3DSA:3.40.50.300 14 188 4.1E-14 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36280 f89bf351dc723970a4e1cfdb137535a8 194 SUPERFAMILY SSF52540 18 191 8.78E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36280 f89bf351dc723970a4e1cfdb137535a8 194 Pfam PF03029 Conserved hypothetical ATP binding protein 22 189 1.3E-27 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS18965 387aa8603e1298367bf8902f9add1739 217 Pfam PF11241 Protein of unknown function (DUF3043) 49 215 9.3E-64 T 17-03-2017 IPR021403 Protein of unknown function DUF3043 SHXM_RS20635 843b5f7b24d7da4b4d2b92267974590b 215 Pfam PF05685 Putative restriction endonuclease 35 198 1.0E-12 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS20635 843b5f7b24d7da4b4d2b92267974590b 215 Gene3D G3DSA:3.90.1570.10 40 178 6.3E-11 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS20635 843b5f7b24d7da4b4d2b92267974590b 215 SUPERFAMILY SSF52980 39 198 1.23E-10 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS45865 4d86fe31831f4e0130b8a571ee36e20d 266 Pfam PF04248 Domain of unknown function (DUF427) 146 239 1.0E-26 T 17-03-2017 IPR007361 Domain of unknown function DUF427 SHXM_RS24975 905908d85d61844576d8532877cc57bf 327 ProSitePatterns PS00134 Serine proteases, trypsin family, histidine active site. 146 151 - T 17-03-2017 IPR018114 Serine proteases, trypsin family, histidine active site GO:0004252|GO:0006508 SHXM_RS24975 905908d85d61844576d8532877cc57bf 327 SUPERFAMILY SSF50494 124 307 3.47E-15 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS24975 905908d85d61844576d8532877cc57bf 327 Gene3D G3DSA:2.40.10.10 127 208 1.3E-10 T 17-03-2017 SHXM_RS19690 d7448bf01e831a29847060e830d10e0d 191 SUPERFAMILY SSF52980 15 160 1.98E-12 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS19690 d7448bf01e831a29847060e830d10e0d 191 Pfam PF05685 Putative restriction endonuclease 16 186 3.5E-21 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS19690 d7448bf01e831a29847060e830d10e0d 191 Gene3D G3DSA:3.90.1570.10 12 166 1.5E-14 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS44020 2f1ed65ef69d70fb9882594e4fdfb777 233 Pfam PF12900 Pyridoxamine 5'-phosphate oxidase 35 183 9.9E-49 T 17-03-2017 IPR024747 Pyridoxamine 5'-phosphate oxidase-related SHXM_RS44020 2f1ed65ef69d70fb9882594e4fdfb777 233 SUPERFAMILY SSF50475 16 205 3.93E-60 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS44020 2f1ed65ef69d70fb9882594e4fdfb777 233 Gene3D G3DSA:2.30.110.10 11 205 1.6E-77 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 Pfam PF01019 Gamma-glutamyltranspeptidase 48 578 1.7E-153 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 287 306 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 461 476 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 55 80 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 485 502 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 425 443 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 257 273 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 130 148 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 148 167 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 PRINTS PR01210 Gamma-glutamyltranspeptidase signature 401 419 1.6E-68 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 TIGRFAM TIGR00066 g_glut_trans: gamma-glutamyltransferase 35 569 9.4E-126 T 17-03-2017 IPR000101 Gamma-glutamyltranspeptidase GO:0003840|GO:0006749 KEGG: 00430+2.3.2.2|KEGG: 00460+2.3.2.2|KEGG: 00480+2.3.2.2+3.4.19.13|MetaCyc: PWY-4041|MetaCyc: PWY-5826 SHXM_RS14895 c141c01bbe03073d2fce9c09d46764cd 590 SUPERFAMILY SSF56235 25 580 7.62E-154 T 17-03-2017 IPR029055 Nucleophile aminohydrolases, N-terminal SHXM_RS22015 573b18ce71a6a52ca2c7dd3c27ee0b05 630 Pfam PF01926 50S ribosome-binding GTPase 146 259 1.0E-6 T 17-03-2017 IPR006073 GTP binding domain GO:0005525 SHXM_RS22015 573b18ce71a6a52ca2c7dd3c27ee0b05 630 SUPERFAMILY SSF52540 138 340 1.4E-22 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS22015 573b18ce71a6a52ca2c7dd3c27ee0b05 630 Gene3D G3DSA:3.40.50.300 134 339 1.1E-21 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41310 3036ec196644cfb68a25a275cfe3725c 340 Pfam PF02626 Allophanate hydrolase subunit 2 29 292 7.0E-57 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS41310 3036ec196644cfb68a25a275cfe3725c 340 SMART SM00797 27 309 2.5E-38 T 17-03-2017 IPR003778 Carboxyltransferase domain, subdomain A and B SHXM_RS20130 0f20e2bad0382d3df664ef7cdab2e6c8 344 Gene3D G3DSA:1.25.40.10 106 297 0.001 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS39785 f39d9723a6d1b9341520d0d2ae9afea9 207 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 4 93 7.8E-13 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS39785 f39d9723a6d1b9341520d0d2ae9afea9 207 SUPERFAMILY SSF51735 4 186 2.81E-32 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39785 f39d9723a6d1b9341520d0d2ae9afea9 207 Gene3D G3DSA:3.40.50.720 3 189 5.8E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS10395 c7c777f238be9ca9f51a2dd24a20c466 187 SUPERFAMILY SSF55826 41 179 4.58E-19 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS10395 c7c777f238be9ca9f51a2dd24a20c466 187 Pfam PF04073 Aminoacyl-tRNA editing domain 49 165 2.2E-12 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS10395 c7c777f238be9ca9f51a2dd24a20c466 187 Gene3D G3DSA:3.90.960.10 42 179 2.3E-21 T 17-03-2017 IPR007214 YbaK/aminoacyl-tRNA synthetase-associated domain GO:0002161 KEGG: 00970+6.1.1.15 SHXM_RS17080 b439afe8b7905fbbab211e8cffe678fc 388 Pfam PF13614 AAA domain 134 309 9.0E-62 T 17-03-2017 IPR025669 AAA domain SHXM_RS17080 b439afe8b7905fbbab211e8cffe678fc 388 SUPERFAMILY SSF52540 133 385 6.6E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS17080 b439afe8b7905fbbab211e8cffe678fc 388 Gene3D G3DSA:3.40.50.300 134 385 1.3E-67 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26295 32431455f205d9f0155c066c237a5259 111 Pfam PF11774 Lsr2 1 109 3.0E-42 T 17-03-2017 IPR024412 Lsr2 SHXM_RS26295 32431455f205d9f0155c066c237a5259 111 ProDom PD026347 LSR2-LIKE LSR2 ANTIGEN IMMUNE PRECURSOR RESPONSE SIGNAL PLASMID LYSYL GP61 1 110 1.0E-37 T 17-03-2017 IPR024412 Lsr2 SHXM_RS24950 2ce68e5135db710cb6be4b83b51adbc4 325 SUPERFAMILY SSF53448 3 232 1.61E-48 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS24950 2ce68e5135db710cb6be4b83b51adbc4 325 Pfam PF00535 Glycosyl transferase family 2 5 121 7.2E-34 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS24950 2ce68e5135db710cb6be4b83b51adbc4 325 Gene3D G3DSA:3.90.550.10 3 203 2.5E-45 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS33050 89503c102578389aa194d5fe0fa4ceac 203 Pfam PF03029 Conserved hypothetical ATP binding protein 27 183 3.4E-20 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS33050 89503c102578389aa194d5fe0fa4ceac 203 PRINTS PR00449 Transforming protein P21 ras signature 81 103 8.6E-5 T 17-03-2017 SHXM_RS33050 89503c102578389aa194d5fe0fa4ceac 203 PRINTS PR00449 Transforming protein P21 ras signature 23 44 8.6E-5 T 17-03-2017 SHXM_RS33050 89503c102578389aa194d5fe0fa4ceac 203 SUPERFAMILY SSF52540 20 195 3.2E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS33050 89503c102578389aa194d5fe0fa4ceac 203 Gene3D G3DSA:3.40.50.300 22 196 1.2E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36625 2b0cd5aaff626e4edd4e44f81d36f55f 119 Hamap MF_00048 UPF0102 protein YraN [yraN]. 4 115 20.555 T 17-03-2017 IPR003509 Uncharacterised protein family UPF0102 SHXM_RS36625 2b0cd5aaff626e4edd4e44f81d36f55f 119 SUPERFAMILY SSF52980 9 106 4.93E-21 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS36625 2b0cd5aaff626e4edd4e44f81d36f55f 119 Gene3D G3DSA:3.40.1350.10 10 118 3.6E-36 T 17-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 SHXM_RS36625 2b0cd5aaff626e4edd4e44f81d36f55f 119 Pfam PF02021 Uncharacterised protein family UPF0102 11 102 2.4E-27 T 17-03-2017 IPR003509 Uncharacterised protein family UPF0102 SHXM_RS05215 9a6a552978e2b9b8a740ebbf64590bc4 467 Gene3D G3DSA:1.20.1250.20 246 443 4.0E-13 T 17-03-2017 SHXM_RS05215 9a6a552978e2b9b8a740ebbf64590bc4 467 Gene3D G3DSA:1.20.1250.20 4 171 1.2E-26 T 17-03-2017 SHXM_RS05215 9a6a552978e2b9b8a740ebbf64590bc4 467 SUPERFAMILY SSF103473 235 431 6.41E-59 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05215 9a6a552978e2b9b8a740ebbf64590bc4 467 SUPERFAMILY SSF103473 2 181 6.41E-59 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS05215 9a6a552978e2b9b8a740ebbf64590bc4 467 Pfam PF07690 Major Facilitator Superfamily 2 396 5.3E-45 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS39145 f21e3e1a30b2092d62ba90ad6f8580bf 112 Gene3D G3DSA:1.20.1250.20 2 83 8.9E-4 T 17-03-2017 SHXM_RS39145 f21e3e1a30b2092d62ba90ad6f8580bf 112 SUPERFAMILY SSF103473 1 88 2.62E-5 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS13280 ef0fb937d5a0238cb882a8a0978c67f4 265 Gene3D G3DSA:3.40.50.1110 16 201 4.3E-39 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13280 ef0fb937d5a0238cb882a8a0978c67f4 265 SUPERFAMILY SSF52266 15 199 5.04E-36 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS13280 ef0fb937d5a0238cb882a8a0978c67f4 265 Pfam PF13472 GDSL-like Lipase/Acylhydrolase family 18 191 3.2E-26 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS18000 20f066c7ad3fb8ba75fe8d58e6d5c791 192 Pfam PF02342 TerD domain 2 183 3.0E-44 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS18000 20f066c7ad3fb8ba75fe8d58e6d5c791 192 Gene3D G3DSA:2.60.60.30 21 182 5.2E-47 T 17-03-2017 SHXM_RS17160 a0f1ca594eac4d93ed70a4d3cee37b80 349 Gene3D G3DSA:1.10.3470.10 19 345 1.0E-100 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS17160 a0f1ca594eac4d93ed70a4d3cee37b80 349 Pfam PF01032 FecCD transport family 36 343 9.1E-90 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS17160 a0f1ca594eac4d93ed70a4d3cee37b80 349 SUPERFAMILY SSF81345 19 344 2.35E-80 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS20180 b6f813e8948ccb55c2b24609f7dbc458 220 Pfam PF01596 O-methyltransferase 22 218 1.5E-52 T 17-03-2017 IPR002935 O-methyltransferase, family 3 GO:0008171 SHXM_RS20180 b6f813e8948ccb55c2b24609f7dbc458 220 SUPERFAMILY SSF53335 10 218 1.77E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS20180 b6f813e8948ccb55c2b24609f7dbc458 220 Gene3D G3DSA:3.40.50.150 6 219 2.6E-68 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS22800 97a64c3ec4ae1b1ac5d31ef68afd5ada 101 Pfam PF02687 FtsX-like permease family 1 94 8.0E-21 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS01650 568036e556f6fcbd70862a9db89a028a 776 SUPERFAMILY SSF55486 259 455 2.94E-16 T 17-03-2017 SHXM_RS01650 568036e556f6fcbd70862a9db89a028a 776 Pfam PF16313 Met-zincin 379 682 1.1E-52 T 17-03-2017 IPR032534 Domian of unknown function DUF4953 SHXM_RS01650 568036e556f6fcbd70862a9db89a028a 776 Pfam PF17148 Domain of unknown function (DUF5117) 63 248 2.7E-10 T 17-03-2017 IPR033413 Domain of unknown function DUF5117 SHXM_RS01650 568036e556f6fcbd70862a9db89a028a 776 Gene3D G3DSA:3.40.390.10 385 453 2.2E-7 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS30125 890ab34e76d110620fbbfc5fd2ad0c1c 297 Gene3D G3DSA:3.40.50.1820 8 124 2.5E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30125 890ab34e76d110620fbbfc5fd2ad0c1c 297 Gene3D G3DSA:3.40.50.1820 167 185 2.5E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30125 890ab34e76d110620fbbfc5fd2ad0c1c 297 Gene3D G3DSA:3.40.50.1820 228 294 2.5E-37 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30125 890ab34e76d110620fbbfc5fd2ad0c1c 297 SUPERFAMILY SSF53474 163 296 4.42E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30125 890ab34e76d110620fbbfc5fd2ad0c1c 297 SUPERFAMILY SSF53474 9 122 4.42E-31 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS30125 890ab34e76d110620fbbfc5fd2ad0c1c 297 Pfam PF00561 alpha/beta hydrolase fold 36 276 1.4E-11 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS08325 176d8926077aee925597167459206611 140 Gene3D G3DSA:3.10.450.50 5 127 1.4E-43 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS08325 176d8926077aee925597167459206611 140 SUPERFAMILY SSF54427 5 126 4.6E-28 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS08325 176d8926077aee925597167459206611 140 Pfam PF12680 SnoaL-like domain 13 116 9.8E-12 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS35730 2d178faac53e57fd59eacaa9ef0c6cfc 640 SUPERFAMILY SSF69318 164 423 8.5E-12 T 17-03-2017 SHXM_RS35730 2d178faac53e57fd59eacaa9ef0c6cfc 640 SUPERFAMILY SSF69318 503 582 8.5E-12 T 17-03-2017 SHXM_RS35730 2d178faac53e57fd59eacaa9ef0c6cfc 640 Gene3D G3DSA:2.130.10.130 164 420 4.3E-4 T 17-03-2017 SHXM_RS50410 fd579346d1a00b6f1c0a35a35a1b2bc7 1341 SUPERFAMILY SSF49785 1212 1325 3.68E-6 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS50410 fd579346d1a00b6f1c0a35a35a1b2bc7 1341 Pfam PF17132 alpha-L-rhamnosidase 176 350 5.1E-13 T 17-03-2017 IPR033400 Alpha-L-rhamnosidase RhaM SHXM_RS48130 3c4e7b732950ca328bfbb5445d1d2390 253 Gene3D G3DSA:3.40.50.150 5 150 1.0E-21 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS48130 3c4e7b732950ca328bfbb5445d1d2390 253 Pfam PF08241 Methyltransferase domain 47 136 3.6E-13 T 17-03-2017 IPR013216 Methyltransferase type 11 GO:0008152|GO:0008168 SHXM_RS48130 3c4e7b732950ca328bfbb5445d1d2390 253 SUPERFAMILY SSF53335 8 216 1.23E-26 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS24560 fdab4ef6c770710842a71fee030c98e8 341 Gene3D G3DSA:1.10.530.10 18 122 5.2E-38 T 17-03-2017 SHXM_RS24560 fdab4ef6c770710842a71fee030c98e8 341 Gene3D G3DSA:3.10.350.10 289 336 7.1E-7 T 17-03-2017 IPR018392 LysM domain SHXM_RS24560 fdab4ef6c770710842a71fee030c98e8 341 SUPERFAMILY SSF53955 41 122 9.0E-27 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS24560 fdab4ef6c770710842a71fee030c98e8 341 Pfam PF06737 Transglycosylase-like domain 41 116 2.3E-31 T 17-03-2017 IPR010618 Transglycosylase-like SHXM_RS24560 fdab4ef6c770710842a71fee030c98e8 341 SMART SM00257 288 337 3.6E-5 T 17-03-2017 IPR018392 LysM domain SHXM_RS30010 44f1a4e862bf7a8002a6f54de82b734f 175 Pfam PF13302 Acetyltransferase (GNAT) domain 25 147 1.8E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS30010 44f1a4e862bf7a8002a6f54de82b734f 175 SUPERFAMILY SSF55729 13 152 1.77E-18 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS30010 44f1a4e862bf7a8002a6f54de82b734f 175 Gene3D G3DSA:3.40.630.30 9 169 2.7E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS46130 f1e3e6a669b31be0904c9f20e2244236 343 Gene3D G3DSA:2.120.10.70 196 329 1.0E-8 T 17-03-2017 SHXM_RS46130 f1e3e6a669b31be0904c9f20e2244236 343 Gene3D G3DSA:2.120.10.70 8 195 5.9E-15 T 17-03-2017 SHXM_RS46130 f1e3e6a669b31be0904c9f20e2244236 343 SUPERFAMILY SSF89372 6 204 9.81E-21 T 17-03-2017 SHXM_RS40760 ce16d824185081257949afd13ca41c7c 107 Pfam PF00550 Phosphopantetheine attachment site 33 82 2.0E-4 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40760 ce16d824185081257949afd13ca41c7c 107 SUPERFAMILY SSF47336 13 102 3.4E-9 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS40760 ce16d824185081257949afd13ca41c7c 107 Gene3D G3DSA:1.10.1200.10 13 99 1.8E-10 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS11535 05ef27c6059a72de95129c8a9f3d4add 93 Pfam PF13244 Domain of unknown function (DUF4040) 11 77 9.3E-18 T 17-03-2017 IPR025383 Domain of unknown function DUF4040 SHXM_RS07975 7067c379cfd35dfd6ac25db1d7f27e0b 423 Pfam PF01565 FAD binding domain 22 148 7.3E-22 T 17-03-2017 IPR006094 FAD linked oxidase, N-terminal GO:0016491|GO:0050660|GO:0055114 SHXM_RS07975 7067c379cfd35dfd6ac25db1d7f27e0b 423 Gene3D G3DSA:3.30.465.10 70 179 1.2E-23 T 17-03-2017 IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2 GO:0050660 SHXM_RS07975 7067c379cfd35dfd6ac25db1d7f27e0b 423 Gene3D G3DSA:3.30.43.10 5 69 3.2E-12 T 17-03-2017 IPR016167 FAD-binding, type 2, subdomain 1 GO:0003824|GO:0050660|GO:0055114 SHXM_RS07975 7067c379cfd35dfd6ac25db1d7f27e0b 423 SUPERFAMILY SSF56176 5 179 1.31E-37 T 17-03-2017 IPR016166 FAD-binding, type 2 GO:0003824|GO:0016614|GO:0050660|GO:0055114 SHXM_RS07975 7067c379cfd35dfd6ac25db1d7f27e0b 423 Pfam PF04030 D-arabinono-1,4-lactone oxidase 293 417 1.2E-15 T 17-03-2017 IPR007173 D-arabinono-1,4-lactone oxidase GO:0003885|GO:0016020|GO:0055114 SHXM_RS04750 33cdc1a7583a6edb2f2c55c7c7a98e3a 237 Gene3D G3DSA:3.40.225.10 10 210 1.4E-55 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS04750 33cdc1a7583a6edb2f2c55c7c7a98e3a 237 SMART SM01007 12 192 2.6E-46 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS04750 33cdc1a7583a6edb2f2c55c7c7a98e3a 237 SUPERFAMILY SSF53639 10 216 6.67E-56 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS04750 33cdc1a7583a6edb2f2c55c7c7a98e3a 237 Pfam PF00596 Class II Aldolase and Adducin N-terminal domain 13 192 1.3E-41 T 17-03-2017 IPR001303 Class II aldolase/adducin N-terminal SHXM_RS24025 2082ad9ef5ff16c605bc9b340b12c3a7 773 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 77 163 3.3E-10 T 17-03-2017 SHXM_RS08435 137d0ff4198a34a811dc4d54f54e0fe5 518 SMART SM00387 262 376 0.0078 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08435 137d0ff4198a34a811dc4d54f54e0fe5 518 Gene3D G3DSA:3.30.565.10 264 373 1.1E-12 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08435 137d0ff4198a34a811dc4d54f54e0fe5 518 Pfam PF02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase 266 373 4.2E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08435 137d0ff4198a34a811dc4d54f54e0fe5 518 SUPERFAMILY SSF55874 252 374 1.19E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS10555 badb122442301f5da42f6616b56ab2bd 224 SMART SM00471 32 125 0.0059 T 17-03-2017 IPR003607 HD/PDEase domain SHXM_RS10555 badb122442301f5da42f6616b56ab2bd 224 Gene3D G3DSA:1.10.3210.10 33 127 9.3E-8 T 17-03-2017 IPR006674 HD domain SHXM_RS10555 badb122442301f5da42f6616b56ab2bd 224 Pfam PF01966 HD domain 36 128 3.5E-7 T 17-03-2017 IPR006674 HD domain SHXM_RS10555 badb122442301f5da42f6616b56ab2bd 224 SUPERFAMILY SSF109604 18 150 8.9E-16 T 17-03-2017 SHXM_RS34790 97913f3f4791f36ef84a47ec53b6db45 285 Pfam PF13349 Putative adhesin 59 263 2.9E-8 T 17-03-2017 IPR025164 Putative adhesin SHXM_RS15235 7466771ece938f6cc5ddfbd6c3ff30c0 196 Pfam PF13358 DDE superfamily endonuclease 19 143 4.3E-20 T 17-03-2017 SHXM_RS17230 3eec118fe0c4d9a183aaa3f4d0302d62 141 Pfam PF01957 NfeD-like C-terminal, partner-binding 7 140 6.5E-17 T 17-03-2017 IPR002810 NfeD-like, C-terminal domain SHXM_RS17230 3eec118fe0c4d9a183aaa3f4d0302d62 141 Gene3D G3DSA:2.40.50.140 81 141 5.4E-24 T 17-03-2017 IPR012340 Nucleic acid-binding, OB-fold SHXM_RS17230 3eec118fe0c4d9a183aaa3f4d0302d62 141 SUPERFAMILY SSF141322 78 140 6.02E-6 T 17-03-2017 SHXM_RS33215 69ad00d24fe38e1916f2d18167e505ef 134 Pfam PF14155 Domain of unknown function (DUF4307) 22 130 6.3E-32 T 17-03-2017 IPR025443 Protein of unknown function DUF4307 SHXM_RS06405 f715440e89f054ad7d05058e3eae2312 155 SUPERFAMILY SSF54427 1 119 2.1E-22 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06405 f715440e89f054ad7d05058e3eae2312 155 Pfam PF12680 SnoaL-like domain 13 109 7.6E-13 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS06405 f715440e89f054ad7d05058e3eae2312 155 Gene3D G3DSA:3.10.450.50 1 120 2.4E-29 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS06790 1f48c2e402ffb93f97eeccd36156b38d 183 Gene3D G3DSA:3.30.1330.110 1 181 2.1E-67 T 17-03-2017 IPR009569 Amino acid synthesis, putative SHXM_RS06790 1f48c2e402ffb93f97eeccd36156b38d 183 Pfam PF06684 Amino acid synthesis 3 176 5.6E-64 T 17-03-2017 IPR009569 Amino acid synthesis, putative SHXM_RS06790 1f48c2e402ffb93f97eeccd36156b38d 183 SUPERFAMILY SSF160519 2 181 1.31E-60 T 17-03-2017 IPR009569 Amino acid synthesis, putative SHXM_RS41120 6c18189606f816d2883da420774de2a6 464 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 17 434 1.9E-52 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS41120 6c18189606f816d2883da420774de2a6 464 PIRSF PIRSF002744 1 459 2.3E-110 T 17-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 SHXM_RS35895 17ea4e02f70025264d30e6f0e1e96b70 278 Pfam PF03631 Virulence factor BrkB 31 253 1.8E-10 T 17-03-2017 IPR017039 Virulence factor BrkB SHXM_RS30980 6312afd8d154be730c771dc11e70ee70 130 Pfam PF03733 Inner membrane component domain 4 54 7.5E-18 T 17-03-2017 IPR005185 Inner membrane component domain SHXM_RS30980 6312afd8d154be730c771dc11e70ee70 130 Pfam PF03733 Inner membrane component domain 68 117 1.3E-16 T 17-03-2017 IPR005185 Inner membrane component domain SHXM_RS30980 6312afd8d154be730c771dc11e70ee70 130 PIRSF PIRSF028777 1 130 3.9E-49 T 17-03-2017 IPR031308 Uncharacterised conserved protein UCP028777 SHXM_RS13680 d9c9e637c52eb45db25043da70c43fe3 61 Pfam PF04149 Domain of unknown function (DUF397) 7 57 3.5E-21 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS29995 867e39555c24aabdb6e04532e0d16b52 118 Pfam PF03795 YCII-related domain 14 98 1.3E-12 T 17-03-2017 IPR005545 YCII-related SHXM_RS29995 867e39555c24aabdb6e04532e0d16b52 118 Gene3D G3DSA:3.30.70.1060 1 116 2.8E-35 T 17-03-2017 SHXM_RS29995 867e39555c24aabdb6e04532e0d16b52 118 SUPERFAMILY SSF54909 4 115 2.68E-27 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS16335 a27b767e765e89ac688528cfce6ed0df 217 Gene3D G3DSA:3.40.50.720 1 199 8.3E-53 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS16335 a27b767e765e89ac688528cfce6ed0df 217 Pfam PF03807 NADP oxidoreductase coenzyme F420-dependent 2 95 3.2E-15 T 17-03-2017 IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal SHXM_RS16335 a27b767e765e89ac688528cfce6ed0df 217 SUPERFAMILY SSF51735 1 196 2.18E-37 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18050 38c5d71a5759f391273ea2398b1e00e3 402 SUPERFAMILY SSF101478 138 377 3.92E-58 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS18050 38c5d71a5759f391273ea2398b1e00e3 402 SUPERFAMILY SSF101478 13 109 3.92E-58 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS18050 38c5d71a5759f391273ea2398b1e00e3 402 Pfam PF03747 ADP-ribosylglycohydrolase 18 356 3.5E-67 T 17-03-2017 IPR005502 ADP-ribosylation/Crystallin J1 SHXM_RS32140 a9f4b532a5a2984eb003f165dd4dd780 181 SUPERFAMILY SSF52499 1 181 1.11E-43 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS32140 a9f4b532a5a2984eb003f165dd4dd780 181 Pfam PF00857 Isochorismatase family 1 174 3.1E-37 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS32140 a9f4b532a5a2984eb003f165dd4dd780 181 Gene3D G3DSA:3.40.50.850 1 181 5.6E-46 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS26655 e292321da7c4321756a2ed5ba1a9dde3 357 Gene3D G3DSA:1.10.600.10 17 338 2.7E-54 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS26655 e292321da7c4321756a2ed5ba1a9dde3 357 Pfam PF00348 Polyprenyl synthetase 36 215 5.6E-28 T 17-03-2017 IPR000092 Polyprenyl synthetase GO:0008299 SHXM_RS26655 e292321da7c4321756a2ed5ba1a9dde3 357 SUPERFAMILY SSF48576 278 338 1.2E-49 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS26655 e292321da7c4321756a2ed5ba1a9dde3 357 SUPERFAMILY SSF48576 21 247 1.2E-49 T 17-03-2017 IPR008949 Isoprenoid synthase domain SHXM_RS42910 242b6a17e7ab524cc9d8ab4faaa6bc39 230 SUPERFAMILY SSF55920 26 226 6.41E-20 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS42910 242b6a17e7ab524cc9d8ab4faaa6bc39 230 Gene3D G3DSA:3.90.230.10 11 195 2.3E-13 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS42910 242b6a17e7ab524cc9d8ab4faaa6bc39 230 Pfam PF00557 Metallopeptidase family M24 14 179 3.1E-16 T 17-03-2017 IPR000994 Peptidase M24, structural domain SHXM_RS38300 ee632f45fc909d7ef435cd8ff97f69c0 268 TIGRFAM TIGR04222 near_uncomplex: TIGR04222 domain 9 254 1.2E-40 T 17-03-2017 IPR026467 Ser/Gly rich, Cys interspersed, C-terminal domain SHXM_RS13980 0c2c194edd6529402d83bb3c37bfd5d7 313 SUPERFAMILY SSF161098 74 301 8.37E-62 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13980 0c2c194edd6529402d83bb3c37bfd5d7 313 Gene3D G3DSA:1.10.3720.10 80 310 9.3E-64 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13980 0c2c194edd6529402d83bb3c37bfd5d7 313 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 305 2.4E-14 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS23100 6b990d8d6e7ece5fa1da190e7aee4eb6 367 SUPERFAMILY SSF53901 40 221 7.2E-18 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23100 6b990d8d6e7ece5fa1da190e7aee4eb6 367 Gene3D G3DSA:3.40.47.10 50 191 1.6E-12 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS23100 6b990d8d6e7ece5fa1da190e7aee4eb6 367 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 65 194 7.0E-8 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS49465 fadb6cffc140eeff3d49bd1b3deeab26 134 SUPERFAMILY SSF51338 50 95 2.03E-5 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49465 fadb6cffc140eeff3d49bd1b3deeab26 134 Gene3D G3DSA:2.30.40.10 46 95 4.7E-8 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49465 fadb6cffc140eeff3d49bd1b3deeab26 134 Pfam PF07969 Amidohydrolase family 50 94 4.5E-8 T 17-03-2017 IPR013108 Amidohydrolase 3 SHXM_RS16695 9cbbe1195a032347213f104da9a45a12 134 Gene3D G3DSA:3.40.47.10 1 69 6.9E-18 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS16695 9cbbe1195a032347213f104da9a45a12 134 Pfam PF16197 Ketoacyl-synthetase C-terminal extension 19 132 6.0E-16 T 17-03-2017 IPR032821 Ketoacyl-synthetase, C-terminal extension Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS16695 9cbbe1195a032347213f104da9a45a12 134 SUPERFAMILY SSF53901 1 69 2.05E-13 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS18030 ad4c1839f1551045ec2704b4bf0dac0f 215 SUPERFAMILY SSF52540 32 187 3.25E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS18030 ad4c1839f1551045ec2704b4bf0dac0f 215 Gene3D G3DSA:3.40.50.300 14 200 6.6E-12 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36960 1c392b9873c4941f26879713a9a3767e 76 Pfam PF04149 Domain of unknown function (DUF397) 23 69 1.7E-9 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS05735 f99c07e5f024bf44c05f984cccf8802c 88 Pfam PF04226 Transglycosylase associated protein 33 83 1.9E-11 T 17-03-2017 IPR007341 Transglycosylase-associated protein GO:0016021 SHXM_RS37370 b9ea47a2c85e03f35bc11c65460eb63a 637 Pfam PF04183 IucA / IucC family 175 408 2.0E-64 T 17-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 SHXM_RS37370 b9ea47a2c85e03f35bc11c65460eb63a 637 Pfam PF06276 Ferric iron reductase FhuF-like transporter 443 604 6.1E-31 T 17-03-2017 IPR022770 Ferric iron reductase FhuF domain SHXM_RS17155 9368265d3aa4b015811bbfaf20ba061b 354 SUPERFAMILY SSF81345 26 346 2.75E-69 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS17155 9368265d3aa4b015811bbfaf20ba061b 354 Gene3D G3DSA:1.10.3470.10 31 350 4.0E-90 T 17-03-2017 IPR029022 ABC transporter, BtuC-like SHXM_RS17155 9368265d3aa4b015811bbfaf20ba061b 354 Pfam PF01032 FecCD transport family 42 346 1.2E-80 T 17-03-2017 IPR000522 ABC transporter, FecCD-like GO:0005215|GO:0016020 SHXM_RS18455 7296205d98af00df1585a1110bf7ff85 435 Pfam PF01936 NYN domain 38 166 3.9E-11 T 17-03-2017 IPR021139 NYN domain, limkain-b1-type SHXM_RS18455 7296205d98af00df1585a1110bf7ff85 435 Gene3D G3DSA:3.40.50.1010 3 171 2.2E-15 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS15420 904dc289d9245d7ab7860f8c0f0a0320 676 SUPERFAMILY SSF52777 212 465 2.0E-18 T 17-03-2017 SHXM_RS15420 904dc289d9245d7ab7860f8c0f0a0320 676 Pfam PF00668 Condensation domain 25 315 1.9E-10 T 17-03-2017 IPR001242 Condensation domain SHXM_RS15420 904dc289d9245d7ab7860f8c0f0a0320 676 SUPERFAMILY SSF52777 23 171 2.67E-13 T 17-03-2017 SHXM_RS37085 328d505916a2e8bed45f7fbc55d23744 153 SUPERFAMILY SSF48452 104 144 4.61E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS37085 328d505916a2e8bed45f7fbc55d23744 153 Gene3D G3DSA:1.25.40.10 108 144 2.4E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS41850 a4f9300a18fa5a3e03ec92ad76007fef 132 Gene3D G3DSA:3.30.1330.40 9 131 4.0E-42 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS41850 a4f9300a18fa5a3e03ec92ad76007fef 132 Pfam PF01042 Endoribonuclease L-PSP 14 130 1.7E-32 T 17-03-2017 IPR006175 YjgF/YER057c/UK114 family SHXM_RS41850 a4f9300a18fa5a3e03ec92ad76007fef 132 SUPERFAMILY SSF55298 5 130 9.11E-34 T 17-03-2017 IPR013813 Endoribonuclease L-PSP/chorismate mutase-like SHXM_RS41620 2c1842e70d10307520d23d7d96b1ba74 323 SUPERFAMILY SSF49899 48 319 1.34E-40 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS41620 2c1842e70d10307520d23d7d96b1ba74 323 Pfam PF00722 Glycosyl hydrolases family 16 112 316 7.5E-9 T 17-03-2017 IPR000757 Glycoside hydrolase family 16 GO:0004553|GO:0005975 SHXM_RS41620 2c1842e70d10307520d23d7d96b1ba74 323 Gene3D G3DSA:2.60.120.200 43 319 3.3E-42 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS12070 fbf4e89579aacc0d9e1ac7f294ad6184 425 Pfam PF01266 FAD dependent oxidoreductase 27 382 8.8E-57 T 17-03-2017 IPR006076 FAD dependent oxidoreductase GO:0016491|GO:0055114 SHXM_RS12070 fbf4e89579aacc0d9e1ac7f294ad6184 425 SUPERFAMILY SSF51905 356 405 2.72E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12070 fbf4e89579aacc0d9e1ac7f294ad6184 425 SUPERFAMILY SSF51905 26 252 2.72E-47 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12070 fbf4e89579aacc0d9e1ac7f294ad6184 425 Gene3D G3DSA:3.50.50.60 170 251 1.9E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12070 fbf4e89579aacc0d9e1ac7f294ad6184 425 Gene3D G3DSA:3.50.50.60 347 401 1.9E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS12070 fbf4e89579aacc0d9e1ac7f294ad6184 425 Gene3D G3DSA:3.50.50.60 19 116 1.9E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS42720 3099fc10654e418e58de97e963b8c0ab 344 SUPERFAMILY SSF51004 16 322 2.22E-43 T 17-03-2017 IPR011048 Cytochrome cd1-nitrite reductase-like, haem d1 domain SHXM_RS42720 3099fc10654e418e58de97e963b8c0ab 344 Pfam PF10282 Lactonase, 7-bladed beta-propeller 10 343 6.8E-94 T 17-03-2017 IPR019405 Lactonase, 7-bladed beta propeller KEGG: 00030+3.1.1.31 SHXM_RS42720 3099fc10654e418e58de97e963b8c0ab 344 Gene3D G3DSA:2.130.10.10 9 343 6.7E-91 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS24430 d373cf79172c62df391184787782ad79 213 Gene3D G3DSA:1.10.3720.10 13 197 1.5E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24430 d373cf79172c62df391184787782ad79 213 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 32 197 5.1E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24430 d373cf79172c62df391184787782ad79 213 SUPERFAMILY SSF161098 14 195 1.3E-36 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS35315 448cc9a8f70ac31e212d8513ec07cb97 107 SUPERFAMILY SSF52091 2 100 1.08E-21 T 17-03-2017 IPR002645 STAS domain SHXM_RS35315 448cc9a8f70ac31e212d8513ec07cb97 107 Pfam PF13466 STAS domain 10 89 1.0E-15 T 17-03-2017 IPR002645 STAS domain SHXM_RS35315 448cc9a8f70ac31e212d8513ec07cb97 107 TIGRFAM TIGR00377 ant_ant_sig: anti-anti-sigma factor 2 98 1.2E-16 T 17-03-2017 IPR003658 Anti-sigma factor antagonist GO:0006355|GO:0045152 SHXM_RS35315 448cc9a8f70ac31e212d8513ec07cb97 107 Gene3D G3DSA:3.30.750.24 2 100 2.9E-26 T 17-03-2017 IPR002645 STAS domain SHXM_RS09025 8b7d121115513bae8b66a2cccb4fce69 130 Pfam PF13358 DDE superfamily endonuclease 17 127 1.1E-7 T 17-03-2017 SHXM_RS49230 8ce41fa769f28b0f3332c2fe44766b6b 128 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 1 74 5.2E-25 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS31515 2f4353283bbea9727cc7e6b84294b789 156 SUPERFAMILY SSF55874 58 124 4.82E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS31515 2f4353283bbea9727cc7e6b84294b789 156 Pfam PF13581 Histidine kinase-like ATPase domain 31 128 1.9E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS41580 39fa1059511d78b990f173088249f9ac 244 Gene3D G3DSA:3.40.50.1820 21 244 1.5E-15 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41580 39fa1059511d78b990f173088249f9ac 244 SUPERFAMILY SSF53474 121 244 3.84E-17 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS41580 39fa1059511d78b990f173088249f9ac 244 SUPERFAMILY SSF53474 21 87 3.84E-17 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS26375 dd775ed95826e51584367de6482d3827 340 Pfam PF02636 Putative S-adenosyl-L-methionine-dependent methyltransferase 110 267 2.3E-11 T 17-03-2017 IPR003788 Putative S-adenosyl-L-methionine-dependent methyltransferase MidA Reactome: R-HSA-6799198 SHXM_RS26375 dd775ed95826e51584367de6482d3827 340 SUPERFAMILY SSF53335 7 328 5.15E-41 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS06850 6a388a87c6315fc8c45152ca33184809 125 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 4 119 1.0E-25 T 17-03-2017 IPR018727 Protein of unknown function DUF2267 SHXM_RS03885 c491c4847175f003847102c4177cbe37 264 SUPERFAMILY SSF51658 5 235 4.56E-26 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS03885 c491c4847175f003847102c4177cbe37 264 Gene3D G3DSA:3.20.20.150 6 235 2.0E-24 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS03885 c491c4847175f003847102c4177cbe37 264 Pfam PF01261 Xylose isomerase-like TIM barrel 76 189 1.7E-16 T 17-03-2017 IPR013022 Xylose isomerase-like, TIM barrel domain SHXM_RS23820 c10a321edd628336d55f8c5e236cebf4 73 SUPERFAMILY SSF56059 2 67 2.45E-8 T 17-03-2017 SHXM_RS03410 2de2450174ca1dafa768cf2cff063797 290 SUPERFAMILY SSF161098 85 266 3.14E-30 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03410 2de2450174ca1dafa768cf2cff063797 290 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 105 278 7.0E-24 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03410 2de2450174ca1dafa768cf2cff063797 290 Gene3D G3DSA:1.10.3720.10 84 278 7.9E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33265 163ddf6e8766740c4c20d976a9874ae9 233 Pfam PF03006 Haemolysin-III related 25 222 2.7E-43 T 17-03-2017 IPR004254 AdipoR/Haemolysin-III-related GO:0016021 SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 Pfam PF07690 Major Facilitator Superfamily 15 328 1.3E-27 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 SUPERFAMILY SSF103473 10 394 1.83E-46 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 PRINTS PR01035 Tetracycline resistance protein signature 46 65 6.3E-6 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 PRINTS PR01035 Tetracycline resistance protein signature 248 268 6.3E-6 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 PRINTS PR01035 Tetracycline resistance protein signature 135 157 6.3E-6 T 17-03-2017 IPR001958 Tetracycline resistance protein TetA/multidrug resistance protein MdtG GO:0005215 SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 Gene3D G3DSA:1.20.1250.20 215 411 1.9E-22 T 17-03-2017 SHXM_RS16490 132b82e21f409eb01faef814e7666400 427 Gene3D G3DSA:1.20.1250.20 11 200 2.7E-14 T 17-03-2017 SHXM_RS25775 e465ea3437a07ea0d3a02f2a86c0c371 964 Pfam PF13625 Helicase conserved C-terminal domain 636 758 5.2E-43 T 17-03-2017 IPR032830 Helicase XPB/Ssl2, N-terminal domain Reactome: R-HSA-112382|Reactome: R-HSA-113418|Reactome: R-HSA-167152|Reactome: R-HSA-167158|Reactome: R-HSA-167160|Reactome: R-HSA-167161|Reactome: R-HSA-167162|Reactome: R-HSA-167172|Reactome: R-HSA-167200|Reactome: R-HSA-167246|Reactome: R-HSA-427413|Reactome: R-HSA-5696395|Reactome: R-HSA-5696400|Reactome: R-HSA-674695|Reactome: R-HSA-6781823|Reactome: R-HSA-6781827|Reactome: R-HSA-6782135|Reactome: R-HSA-6782210|Reactome: R-HSA-6796648|Reactome: R-HSA-72086|Reactome: R-HSA-73762|Reactome: R-HSA-73772|Reactome: R-HSA-73776|Reactome: R-HSA-73777|Reactome: R-HSA-73779|Reactome: R-HSA-73863|Reactome: R-HSA-75953|Reactome: R-HSA-75955|Reactome: R-HSA-76042|Reactome: R-HSA-77075 SHXM_RS16025 44334cbc68b1cad6e06e4838166dae32 345 Pfam PF02653 Branched-chain amino acid transport system / permease component 59 333 7.3E-41 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS38705 ca90e48eeacf0c2a82b1ceb2c078d7ab 250 SUPERFAMILY SSF53800 5 240 9.92E-46 T 17-03-2017 SHXM_RS38705 ca90e48eeacf0c2a82b1ceb2c078d7ab 250 Pfam PF01903 CbiX 139 233 4.0E-11 T 17-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 SHXM_RS38705 ca90e48eeacf0c2a82b1ceb2c078d7ab 250 Pfam PF01903 CbiX 11 115 9.9E-26 T 17-03-2017 IPR002762 Cobalamin (vitamin B12) biosynthesis CbiX GO:0009236|GO:0016852 KEGG: 00860+4.99.1.3|MetaCyc: PWY-7377 SHXM_RS38705 ca90e48eeacf0c2a82b1ceb2c078d7ab 250 Gene3D G3DSA:3.40.50.1400 4 122 8.0E-31 T 17-03-2017 SHXM_RS38705 ca90e48eeacf0c2a82b1ceb2c078d7ab 250 Gene3D G3DSA:3.40.50.1400 130 241 1.2E-17 T 17-03-2017 SHXM_RS08725 f8408bb479934ea1341435adc0c15185 237 SMART SM00014 104 214 1.0E-13 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS08725 f8408bb479934ea1341435adc0c15185 237 SUPERFAMILY SSF48317 59 218 3.4E-26 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS08725 f8408bb479934ea1341435adc0c15185 237 Pfam PF01569 PAP2 superfamily 108 214 2.7E-15 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS08725 f8408bb479934ea1341435adc0c15185 237 Gene3D G3DSA:1.20.144.10 65 216 6.0E-26 T 17-03-2017 IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase SHXM_RS04735 3a19728a8f1052a121a5e3129bef49c3 312 Gene3D G3DSA:1.10.3720.10 42 298 2.0E-65 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04735 3a19728a8f1052a121a5e3129bef49c3 312 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 123 304 1.5E-18 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS04735 3a19728a8f1052a121a5e3129bef49c3 312 SUPERFAMILY SSF161098 41 308 3.27E-68 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS40060 8c9fa9b4570082cfb6b1188e179d4a41 149 SUPERFAMILY SSF47113 2 149 1.47E-57 T 17-03-2017 IPR009072 Histone-fold GO:0046982 SHXM_RS40060 8c9fa9b4570082cfb6b1188e179d4a41 149 Pfam PF09123 Domain of unknown function (DUF1931) 9 145 3.7E-59 T 17-03-2017 IPR015207 Protein of unknown function DUF1931 SHXM_RS40060 8c9fa9b4570082cfb6b1188e179d4a41 149 Gene3D G3DSA:1.10.20.10 1 149 1.3E-69 T 17-03-2017 IPR009072 Histone-fold GO:0046982 SHXM_RS45220 82c1f7a4a94d20a89f8a78a3bf2fce2f 754 Pfam PF04984 Phage tail sheath protein 1 746 1.4E-66 T 17-03-2017 IPR007067 Tail sheath protein SHXM_RS39855 d121b6f16efd1f1b3db26213e5f4d8d4 525 Pfam PF13556 PucR C-terminal helix-turn-helix domain 458 515 4.0E-19 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS06290 b8c06abd7acc715ef34e90ee90ca6fd5 418 Pfam PF01757 Acyltransferase family 35 389 2.2E-24 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS25400 d520a7aa1ad4fb241535e220ad047e3c 193 Pfam PF07681 DoxX 44 146 6.1E-19 T 17-03-2017 IPR032808 DoxX family SHXM_RS31925 9cefff34a569e6b52e239bf9acc33990 249 Gene3D G3DSA:1.10.3630.10 3 233 6.3E-41 T 17-03-2017 SHXM_RS31925 9cefff34a569e6b52e239bf9acc33990 249 Pfam PF05719 Golgi phosphoprotein 3 (GPP34) 8 202 1.7E-46 T 17-03-2017 IPR008628 Golgi phosphoprotein 3 GO:0048193|GO:0070273 SHXM_RS37180 671f1bb1bc82dc6281d5244764662915 172 Gene3D G3DSA:3.90.950.20 6 157 1.4E-56 T 17-03-2017 IPR008136 CinA, C-terminal SHXM_RS37180 671f1bb1bc82dc6281d5244764662915 172 Pfam PF02464 Competence-damaged protein 7 155 7.5E-50 T 17-03-2017 IPR008136 CinA, C-terminal SHXM_RS37180 671f1bb1bc82dc6281d5244764662915 172 TIGRFAM TIGR00199 PncC_domain: amidohydrolase, PncC family 12 154 1.4E-36 T 17-03-2017 IPR008136 CinA, C-terminal SHXM_RS37180 671f1bb1bc82dc6281d5244764662915 172 SUPERFAMILY SSF142433 6 157 1.57E-46 T 17-03-2017 IPR008136 CinA, C-terminal SHXM_RS03085 62846ca4744564d1214d3cb5120928bc 266 SUPERFAMILY SSF81301 12 64 3.27E-5 T 17-03-2017 SHXM_RS03085 62846ca4744564d1214d3cb5120928bc 266 Pfam PF13427 Domain of unknown function (DUF4111) 161 254 4.4E-7 T 17-03-2017 IPR025184 Domain of unknown function DUF4111 SHXM_RS03085 62846ca4744564d1214d3cb5120928bc 266 Gene3D G3DSA:3.30.460.10 18 65 2.7E-6 T 17-03-2017 SHXM_RS12080 84d3408305f28ba52983db51a2029efd 301 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 116 286 7.9E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12080 84d3408305f28ba52983db51a2029efd 301 SUPERFAMILY SSF161098 93 280 2.35E-28 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12080 84d3408305f28ba52983db51a2029efd 301 Gene3D G3DSA:1.10.3720.10 89 294 5.8E-27 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50525 a74aadfd8efe10b53629af948e61ce8d 48 Pfam PF13276 HTH-like domain 1 34 1.6E-6 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS42840 26139cf1a482ea54ff406efa39606e67 685 SUPERFAMILY SSF53067 32 98 1.85E-15 T 17-03-2017 SHXM_RS42840 26139cf1a482ea54ff406efa39606e67 685 SUPERFAMILY SSF53067 252 350 1.85E-15 T 17-03-2017 SHXM_RS42840 26139cf1a482ea54ff406efa39606e67 685 SUPERFAMILY SSF53067 134 218 1.85E-15 T 17-03-2017 SHXM_RS42840 26139cf1a482ea54ff406efa39606e67 685 Pfam PF02543 Carbamoyltransferase N-terminus 27 344 5.2E-60 T 17-03-2017 IPR003696 Carbamoyltransferase GO:0003824|GO:0009058 SHXM_RS42840 26139cf1a482ea54ff406efa39606e67 685 Pfam PF16861 Carbamoyltransferase C-terminus 400 571 1.6E-63 T 17-03-2017 IPR031730 Carbamoyltransferase, C-terminal SHXM_RS10585 81576caaa1b496fe488a6d9aa7612474 322 Gene3D G3DSA:2.120.10.30 48 303 1.8E-29 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS10585 81576caaa1b496fe488a6d9aa7612474 322 SUPERFAMILY SSF63829 38 304 1.7E-24 T 17-03-2017 SHXM_RS43570 930a622a1dc5040fb8c4a0ecb4e05fa0 518 SUPERFAMILY SSF51905 1 322 6.85E-34 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43570 930a622a1dc5040fb8c4a0ecb4e05fa0 518 Gene3D G3DSA:3.50.50.60 209 310 4.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43570 930a622a1dc5040fb8c4a0ecb4e05fa0 518 Gene3D G3DSA:3.50.50.60 5 73 4.0E-30 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS43570 930a622a1dc5040fb8c4a0ecb4e05fa0 518 Pfam PF01593 Flavin containing amine oxidoreductase 18 305 1.6E-11 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS31430 03faee14431413fab14509dc861d4871 402 Pfam PF12697 Alpha/beta hydrolase family 119 378 6.7E-19 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS31430 03faee14431413fab14509dc861d4871 402 SUPERFAMILY SSF53474 108 386 9.38E-50 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS31430 03faee14431413fab14509dc861d4871 402 Gene3D G3DSA:3.40.50.1820 102 387 3.8E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS35930 a708e482f47c89c4475c53b6b3624e19 111 SUPERFAMILY SSF48371 42 90 7.05E-6 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS35930 a708e482f47c89c4475c53b6b3624e19 111 Gene3D G3DSA:1.25.10.10 47 102 3.9E-6 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS21060 7f341a114a15eca171dbcaa2b75240b1 389 Pfam PF07690 Major Facilitator Superfamily 8 317 2.5E-30 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS21060 7f341a114a15eca171dbcaa2b75240b1 389 Gene3D G3DSA:1.20.1250.20 200 372 3.0E-9 T 17-03-2017 SHXM_RS21060 7f341a114a15eca171dbcaa2b75240b1 389 Gene3D G3DSA:1.20.1250.20 6 176 4.0E-24 T 17-03-2017 SHXM_RS21060 7f341a114a15eca171dbcaa2b75240b1 389 SUPERFAMILY SSF103473 4 380 2.75E-48 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS28910 091ebb0d84074a8f0925f3ae84784621 228 Pfam PF14016 Protein of unknown function (DUF4232) 95 212 5.0E-13 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS01900 cc32840074fe41393a0b2ee2b3501697 375 SUPERFAMILY SSF51679 158 371 3.72E-67 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01900 cc32840074fe41393a0b2ee2b3501697 375 SUPERFAMILY SSF51679 5 116 3.72E-67 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01900 cc32840074fe41393a0b2ee2b3501697 375 Gene3D G3DSA:3.20.20.30 5 116 1.5E-97 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01900 cc32840074fe41393a0b2ee2b3501697 375 Gene3D G3DSA:3.20.20.30 158 371 1.5E-97 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01900 cc32840074fe41393a0b2ee2b3501697 375 Pfam PF00296 Luciferase-like monooxygenase 184 344 1.4E-10 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS01900 cc32840074fe41393a0b2ee2b3501697 375 Pfam PF00296 Luciferase-like monooxygenase 14 119 1.9E-23 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS13180 3a399bcf3e5a3d0a44e231b4fadd22eb 398 Pfam PF01168 Alanine racemase, N-terminal domain 25 271 5.2E-17 T 17-03-2017 IPR001608 Alanine racemase, N-terminal KEGG: 00473+5.1.1.1|MetaCyc: PWY-7383 SHXM_RS13180 3a399bcf3e5a3d0a44e231b4fadd22eb 398 SUPERFAMILY SSF51419 25 285 4.86E-20 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS13180 3a399bcf3e5a3d0a44e231b4fadd22eb 398 Gene3D G3DSA:3.20.20.10 117 273 5.0E-7 T 17-03-2017 IPR029066 PLP-binding barrel SHXM_RS46065 661abc77cce722561ae857aa87d34a72 90 Pfam PF13701 Transposase DDE domain group 1 2 86 1.0E-18 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS42125 568489d179adb6faa7c67017d608285e 207 Pfam PF02780 Transketolase, C-terminal domain 80 194 3.2E-30 T 17-03-2017 IPR033248 Transketolase, C-terminal domain SHXM_RS42125 568489d179adb6faa7c67017d608285e 207 SUPERFAMILY SSF52922 77 202 1.7E-31 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS42125 568489d179adb6faa7c67017d608285e 207 Gene3D G3DSA:3.40.50.920 80 202 4.9E-35 T 17-03-2017 IPR009014 Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II GO:0003824|GO:0008152 SHXM_RS42685 74585bab59297efc8054827b22507fb7 478 Pfam PF09362 Domain of unknown function (DUF1996) 235 457 6.2E-25 T 17-03-2017 IPR018535 Domain of unknown function DUF1996 SHXM_RS38040 541c726122f6edcbfbbfd28a85305f65 311 SUPERFAMILY SSF161098 73 298 1.19E-59 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38040 541c726122f6edcbfbbfd28a85305f65 311 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 106 307 7.6E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS38040 541c726122f6edcbfbbfd28a85305f65 311 Gene3D G3DSA:1.10.3720.10 79 306 2.0E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS07925 dc30c54c8c290d3325038a408efa4d35 126 Pfam PF00741 Gas vesicle protein 29 67 8.7E-17 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS07925 dc30c54c8c290d3325038a408efa4d35 126 ProSitePatterns PS00234 Gas vesicles protein GVPa signature 1. 30 44 - T 17-03-2017 IPR018493 Gas vesicle protein GvpA, conserved site GO:0005198|GO:0012506 SHXM_RS36025 71b8db7d66919b6b215e0b4fe9849475 389 Gene3D G3DSA:3.40.640.10 15 251 3.0E-71 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS36025 71b8db7d66919b6b215e0b4fe9849475 389 SUPERFAMILY SSF53383 1 381 7.05E-93 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS36025 71b8db7d66919b6b215e0b4fe9849475 389 Gene3D G3DSA:3.90.1150.10 252 376 4.8E-37 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS36025 71b8db7d66919b6b215e0b4fe9849475 389 Pfam PF00266 Aminotransferase class-V 2 372 4.2E-61 T 17-03-2017 IPR000192 Aminotransferase class V domain SHXM_RS36025 71b8db7d66919b6b215e0b4fe9849475 389 PIRSF PIRSF005572 1 386 4.4E-108 T 17-03-2017 IPR016454 Cysteine desulfurase KEGG: 00730+2.8.1.7|MetaCyc: PWY-6823|MetaCyc: PWY-6891|MetaCyc: PWY-6892|MetaCyc: PWY-7250 SHXM_RS01325 3368e83270f4b9a89b25b7189e90404a 318 Pfam PF01636 Phosphotransferase enzyme family 53 256 6.4E-25 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS01325 3368e83270f4b9a89b25b7189e90404a 318 SUPERFAMILY SSF56112 17 270 2.04E-28 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS01325 3368e83270f4b9a89b25b7189e90404a 318 Gene3D G3DSA:3.90.1200.10 129 270 3.3E-17 T 17-03-2017 SHXM_RS50955 d22b5f399a886ca33a47c360b8953332 125 SMART SM00530 14 68 1.1E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS50955 d22b5f399a886ca33a47c360b8953332 125 Gene3D G3DSA:1.10.260.40 15 111 1.3E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS50955 d22b5f399a886ca33a47c360b8953332 125 Pfam PF01381 Helix-turn-helix 17 66 1.5E-6 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS50955 d22b5f399a886ca33a47c360b8953332 125 SUPERFAMILY SSF47413 10 73 4.79E-9 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS03865 380e1c104b6754255091b06b1020c525 540 SUPERFAMILY SSF56300 161 529 1.98E-44 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS03865 380e1c104b6754255091b06b1020c525 540 Gene3D G3DSA:2.60.40.380 64 156 4.1E-15 T 17-03-2017 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 SHXM_RS03865 380e1c104b6754255091b06b1020c525 540 SUPERFAMILY SSF49363 58 156 1.31E-19 T 17-03-2017 IPR008963 Purple acid phosphatase-like, N-terminal GO:0003993|GO:0046872 SHXM_RS03865 380e1c104b6754255091b06b1020c525 540 Gene3D G3DSA:3.60.21.10 160 535 2.7E-69 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS03865 380e1c104b6754255091b06b1020c525 540 Pfam PF00149 Calcineurin-like phosphoesterase 213 395 6.7E-13 T 17-03-2017 IPR004843 Calcineurin-like phosphoesterase domain, apaH type GO:0016787 SHXM_RS03865 380e1c104b6754255091b06b1020c525 540 Pfam PF16656 Purple acid Phosphatase, N-terminal domain 63 154 2.9E-14 T 17-03-2017 IPR015914 Purple acid phosphatase, N-terminal GO:0003993|GO:0046872 SHXM_RS38845 5cd34fba6ddca04a436c79b8716b7ce9 293 Gene3D G3DSA:1.25.40.10 121 269 3.1E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS25060 799cfdb876a33842914e39878f7a87d2 237 SUPERFAMILY SSF56037 61 226 8.11E-24 T 17-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 SHXM_RS25060 799cfdb876a33842914e39878f7a87d2 237 SMART SM00873 71 225 2.0E-9 T 17-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 SHXM_RS25060 799cfdb876a33842914e39878f7a87d2 237 Gene3D G3DSA:3.50.40.10 65 197 2.3E-10 T 17-03-2017 IPR020825 Phenylalanyl-tRNA synthetase, B3/B4 Reactome: R-HSA-379716 SHXM_RS25060 799cfdb876a33842914e39878f7a87d2 237 Pfam PF03483 B3/4 domain 72 207 1.9E-16 T 17-03-2017 IPR005146 B3/B4 tRNA-binding domain GO:0003723|GO:0004826 KEGG: 00970+6.1.1.20 SHXM_RS27945 73601817b42590aa06e24b345d68bb9a 309 SUPERFAMILY SSF53474 225 305 4.5E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27945 73601817b42590aa06e24b345d68bb9a 309 SUPERFAMILY SSF53474 13 142 4.5E-32 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27945 73601817b42590aa06e24b345d68bb9a 309 Gene3D G3DSA:3.40.50.1820 18 304 5.3E-36 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS27945 73601817b42590aa06e24b345d68bb9a 309 Pfam PF12697 Alpha/beta hydrolase family 41 290 6.5E-14 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS06140 5652a166da01a0755d5e2d314e5c5916 218 Gene3D G3DSA:1.10.357.10 25 217 3.4E-37 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS06140 5652a166da01a0755d5e2d314e5c5916 218 SUPERFAMILY SSF46689 23 87 3.33E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS06140 5652a166da01a0755d5e2d314e5c5916 218 Pfam PF00440 Bacterial regulatory proteins, tetR family 29 75 1.1E-4 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS06140 5652a166da01a0755d5e2d314e5c5916 218 SUPERFAMILY SSF48498 103 213 6.16E-7 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS15705 a1e3d2943737712ada4c81b67cb5c5c1 401 ProSitePatterns PS01007 Transposases, Mutator family, signature. 225 249 - T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS15705 a1e3d2943737712ada4c81b67cb5c5c1 401 Pfam PF00872 Transposase, Mutator family 2 370 2.6E-65 T 17-03-2017 IPR001207 Transposase, mutator type GO:0003677|GO:0004803|GO:0006313 SHXM_RS38835 633cf8e011d7767a3255f038ff240910 385 Pfam PF10935 Protein of unknown function (DUF2637) 60 219 1.8E-24 T 17-03-2017 IPR021235 Protein of unknown function DUF2637 SHXM_RS40065 96175feb6aaade9afbd406998eae2380 604 Pfam PF13520 Amino acid permease 51 420 4.5E-22 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 Gene3D G3DSA:3.50.50.60 3 69 2.5E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 Gene3D G3DSA:3.50.50.60 148 235 2.5E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 Gene3D G3DSA:3.50.50.60 319 403 2.5E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 SUPERFAMILY SSF51905 327 433 1.86E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 SUPERFAMILY SSF51905 142 230 1.86E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 SUPERFAMILY SSF51905 2 61 1.86E-53 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 Pfam PF01494 FAD binding domain 3 396 2.0E-68 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 364 382 5.0E-41 T 17-03-2017 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 331 346 5.0E-41 T 17-03-2017 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 346 362 5.0E-41 T 17-03-2017 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 209 224 5.0E-41 T 17-03-2017 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 382 398 5.0E-41 T 17-03-2017 SHXM_RS27455 ddc2e0468af97a00cb289d099af547f4 583 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 5.0E-41 T 17-03-2017 SHXM_RS44545 7cd3aeaeb9b17641cce1d208957dde78 100 Pfam PF01844 HNH endonuclease 33 78 2.9E-6 T 17-03-2017 IPR002711 HNH endonuclease GO:0003676|GO:0004519 SHXM_RS20865 e1bf413805783d80a87bb9db050fefd2 312 SUPERFAMILY SSF161098 65 299 2.22E-44 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20865 e1bf413805783d80a87bb9db050fefd2 312 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 98 300 8.3E-11 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS20865 e1bf413805783d80a87bb9db050fefd2 312 Gene3D G3DSA:1.10.3720.10 71 306 2.6E-50 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50950 368fde061b9837a3ccdfd18d0dfde947 165 Pfam PF06114 Domain of unknown function (DUF955) 32 147 1.9E-16 T 17-03-2017 IPR010359 HTH domain, IrrE-type SHXM_RS35345 db9c604b8ee68dbb0dcc3c835eaa3bdf 276 Pfam PF12679 ABC-2 family transporter protein 84 276 8.3E-8 T 17-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 SHXM_RS07695 d6525518a43740a377d5a1c8e47b2464 606 TIGRFAM TIGR04267 mod_HExxH: HEXXH motif domain 18 414 2.5E-127 T 17-03-2017 IPR026337 HEXXH motif domain SHXM_RS30565 e83689ca2a6e656e11928b8d2e0c57c6 78 Gene3D G3DSA:3.30.70.20 1 62 8.5E-13 T 17-03-2017 SHXM_RS30565 e83689ca2a6e656e11928b8d2e0c57c6 78 SUPERFAMILY SSF54862 1 60 3.54E-11 T 17-03-2017 SHXM_RS30565 e83689ca2a6e656e11928b8d2e0c57c6 78 Pfam PF13370 4Fe-4S single cluster domain of Ferredoxin I 5 60 2.2E-11 T 17-03-2017 SHXM_RS39980 a1797faa0e530613bbd63f15a0f001ad 70 Pfam PF13613 Helix-turn-helix of DDE superfamily endonuclease 40 70 2.2E-9 T 17-03-2017 IPR027805 Transposase, Helix-turn-helix domain SHXM_RS50960 20faea2a239dd5a35526b0d93a97bbeb 1127 Pfam PF03457 Helicase associated domain 781 841 2.2E-14 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50960 20faea2a239dd5a35526b0d93a97bbeb 1127 Pfam PF03457 Helicase associated domain 492 538 2.1E-8 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50960 20faea2a239dd5a35526b0d93a97bbeb 1127 Pfam PF03457 Helicase associated domain 346 402 1.3E-9 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS40565 59f0c734a402b35b363857ed87ffd67f 108 Gene3D G3DSA:1.10.357.10 26 107 4.4E-4 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS40565 59f0c734a402b35b363857ed87ffd67f 108 SUPERFAMILY SSF48498 12 104 2.45E-11 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS42060 070f83523d2b2ce4b601d24101cfe106 168 Pfam PF12306 Inclusion body protein 4 164 9.1E-52 T 17-03-2017 IPR021087 Uncharacterised protein family PixA/AidA SHXM_RS15125 d158264fb12a698866576f76d2c402ca 131 SUPERFAMILY SSF118215 16 121 1.31E-29 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS15125 d158264fb12a698866576f76d2c402ca 131 Pfam PF00375 Sodium:dicarboxylate symporter family 17 121 2.8E-30 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS15125 d158264fb12a698866576f76d2c402ca 131 PRINTS PR00173 Glutamate-aspartate symporter signature 16 42 3.6E-12 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS15125 d158264fb12a698866576f76d2c402ca 131 PRINTS PR00173 Glutamate-aspartate symporter signature 78 98 3.6E-12 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS15125 d158264fb12a698866576f76d2c402ca 131 PRINTS PR00173 Glutamate-aspartate symporter signature 51 70 3.6E-12 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS15125 d158264fb12a698866576f76d2c402ca 131 Gene3D G3DSA:1.10.3860.10 17 127 1.1E-31 T 17-03-2017 IPR001991 Sodium:dicarboxylate symporter GO:0015293|GO:0016021 SHXM_RS37955 72bc7904733a3cc9c4333f5c654e0424 514 SUPERFAMILY SSF103473 17 216 2.75E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS37955 72bc7904733a3cc9c4333f5c654e0424 514 SUPERFAMILY SSF103473 289 493 2.75E-56 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS37955 72bc7904733a3cc9c4333f5c654e0424 514 Gene3D G3DSA:1.20.1250.20 24 210 6.4E-28 T 17-03-2017 SHXM_RS37955 72bc7904733a3cc9c4333f5c654e0424 514 Pfam PF07690 Major Facilitator Superfamily 39 222 7.5E-31 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS37955 72bc7904733a3cc9c4333f5c654e0424 514 Gene3D G3DSA:1.20.1250.20 299 460 8.6E-13 T 17-03-2017 SHXM_RS35650 4bd3cc25c94dfc49a45421acf2907814 333 SUPERFAMILY SSF51445 51 306 9.3E-19 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS35650 4bd3cc25c94dfc49a45421acf2907814 333 Pfam PF00704 Glycosyl hydrolases family 18 62 229 2.3E-7 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS35650 4bd3cc25c94dfc49a45421acf2907814 333 Gene3D G3DSA:3.20.20.80 69 304 9.3E-14 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS36720 09fdcc10e712273f66f651daa9c0dc47 490 Pfam PF00474 Sodium:solute symporter family 33 420 7.2E-37 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS23680 3348869123bde53444195832841c3e6c 95 Pfam PF11238 Protein of unknown function (DUF3039) 26 81 7.3E-32 T 17-03-2017 IPR021400 Protein of unknown function DUF3039 SHXM_RS36880 c982807fa3c339a6d17b6042384c83f2 281 Pfam PF13312 Domain of unknown function (DUF4081) 48 152 1.9E-43 T 17-03-2017 IPR025289 Domain of unknown function DUF4081 SHXM_RS36880 c982807fa3c339a6d17b6042384c83f2 281 Pfam PF00583 Acetyltransferase (GNAT) family 208 271 1.5E-10 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS36880 c982807fa3c339a6d17b6042384c83f2 281 SUPERFAMILY SSF55729 7 276 2.13E-21 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS36880 c982807fa3c339a6d17b6042384c83f2 281 PIRSF PIRSF021603 2 281 2.8E-134 T 17-03-2017 IPR016794 Uncharacterised conserved protein UCP21603, acetyltransferase-like SHXM_RS36880 c982807fa3c339a6d17b6042384c83f2 281 Gene3D G3DSA:3.40.630.30 131 277 1.9E-20 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS33480 eba1abc37339e3b3322c1e8ea0a75cd3 235 Pfam PF13400 Putative Flp pilus-assembly TadE/G-like 12 59 7.0E-5 T 17-03-2017 IPR028087 Putative Flp pilus-assembly TadG-like, N-terminal SHXM_RS06165 d8fd99320a83cca9cf0e9fb3d89550c2 70 Gene3D G3DSA:3.40.50.1820 6 67 6.9E-11 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS06165 d8fd99320a83cca9cf0e9fb3d89550c2 70 SUPERFAMILY SSF53474 3 67 2.0E-11 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34570 82f15e5a4283ebc6afe76942c6c4e028 537 Pfam PF00474 Sodium:solute symporter family 44 404 7.6E-20 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS47440 c4c2501a253a5db0b101a468d2865d56 203 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 55 189 1.7E-17 T 17-03-2017 IPR014284 RNA polymerase sigma-70 like domain GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS47440 c4c2501a253a5db0b101a468d2865d56 203 SUPERFAMILY SSF88659 127 190 4.49E-16 T 17-03-2017 IPR013324 RNA polymerase sigma factor, region 3/4 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS47440 c4c2501a253a5db0b101a468d2865d56 203 Pfam PF08281 Sigma-70, region 4 136 185 3.2E-15 T 17-03-2017 IPR013249 RNA polymerase sigma factor 70, region 4 type 2 GO:0003677|GO:0003700|GO:0006352|GO:0006355|GO:0016987 SHXM_RS47440 c4c2501a253a5db0b101a468d2865d56 203 Gene3D G3DSA:1.10.10.10 127 191 2.7E-21 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS49580 aeb34fb52577aa3064bb5f7c2da437a8 483 Pfam PF00135 Carboxylesterase family 4 461 4.6E-89 T 17-03-2017 IPR002018 Carboxylesterase, type B SHXM_RS49580 aeb34fb52577aa3064bb5f7c2da437a8 483 Gene3D G3DSA:3.40.50.1820 5 481 1.1E-117 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS49580 aeb34fb52577aa3064bb5f7c2da437a8 483 ProSitePatterns PS00122 Carboxylesterases type-B serine active site. 173 188 - T 17-03-2017 IPR019826 Carboxylesterase type B, active site SHXM_RS49580 aeb34fb52577aa3064bb5f7c2da437a8 483 SUPERFAMILY SSF53474 3 481 5.9E-104 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS15840 ae6932d249a28283a03a5e838cae0884 260 Pfam PF01833 IPT/TIG domain 3 78 6.1E-8 T 17-03-2017 IPR002909 IPT domain GO:0005515 SHXM_RS15840 ae6932d249a28283a03a5e838cae0884 260 Gene3D G3DSA:2.60.40.10 3 74 4.4E-9 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15840 ae6932d249a28283a03a5e838cae0884 260 Gene3D G3DSA:2.60.40.10 84 161 2.4E-4 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS15840 ae6932d249a28283a03a5e838cae0884 260 SUPERFAMILY SSF81296 3 80 7.7E-10 T 17-03-2017 IPR014756 Immunoglobulin E-set SHXM_RS15840 ae6932d249a28283a03a5e838cae0884 260 Gene3D G3DSA:2.60.40.10 169 257 3.2E-5 T 17-03-2017 IPR013783 Immunoglobulin-like fold SHXM_RS04630 6af3882ed8716dff068be8d8cd095327 285 Pfam PF01874 ATP:dephospho-CoA triphosphoribosyl transferase 10 272 1.8E-55 T 17-03-2017 IPR002736 Triphosphoribosyl-dephospho-CoA protein GO:0005524|GO:0016310|GO:0046917 MetaCyc: PWY-5796 SHXM_RS44810 9db9a3c30a1ae89d0199fd5264d66426 382 Pfam PF04332 Protein of unknown function (DUF475) 44 361 2.1E-142 T 17-03-2017 IPR007427 Protein of unknown function DUF475 SHXM_RS44310 88c395a83810ad424354c9416ab10896 93 SUPERFAMILY SSF56529 3 84 4.06E-16 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS44310 88c395a83810ad424354c9416ab10896 93 Gene3D G3DSA:3.90.850.10 2 87 4.3E-15 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS44310 88c395a83810ad424354c9416ab10896 93 Pfam PF01557 Fumarylacetoacetate (FAA) hydrolase family 2 83 4.1E-14 T 17-03-2017 IPR011234 Fumarylacetoacetase, C-terminal-related GO:0003824|GO:0008152 SHXM_RS38190 013b025a33f2d8853b330c3c816cebe3 366 Gene3D G3DSA:3.40.50.2300 39 163 1.7E-28 T 17-03-2017 SHXM_RS38190 013b025a33f2d8853b330c3c816cebe3 366 Gene3D G3DSA:3.40.50.2300 164 338 2.1E-36 T 17-03-2017 SHXM_RS38190 013b025a33f2d8853b330c3c816cebe3 366 Pfam PF13407 Periplasmic binding protein domain 47 304 5.9E-61 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS38190 013b025a33f2d8853b330c3c816cebe3 366 SUPERFAMILY SSF53822 44 339 8.92E-60 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS35905 48a467256b19fa7ab4538ed3f44a78cc 550 SUPERFAMILY SSF111331 121 409 1.44E-48 T 17-03-2017 IPR016064 NAD kinase/diacylglycerol kinase-like domain SHXM_RS35905 48a467256b19fa7ab4538ed3f44a78cc 550 Pfam PF00781 Diacylglycerol kinase catalytic domain 126 246 2.0E-18 T 17-03-2017 IPR001206 Diacylglycerol kinase, catalytic domain GO:0016301 SHXM_RS35905 48a467256b19fa7ab4538ed3f44a78cc 550 Gene3D G3DSA:3.40.50.10330 174 238 7.3E-5 T 17-03-2017 IPR017438 Inorganic polyphosphate/ATP-NAD kinase, domain 1 GO:0003951|GO:0008152 KEGG: 00760+2.7.1.23|MetaCyc: PWY-5083|MetaCyc: PWY-7268|MetaCyc: PWY-7269 SHXM_RS36035 eaaf2af321bc82a302e5149f973bbf5b 239 SMART SM00644 91 220 5.6E-38 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS36035 eaaf2af321bc82a302e5149f973bbf5b 239 Gene3D G3DSA:3.40.80.10 91 233 1.7E-42 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS36035 eaaf2af321bc82a302e5149f973bbf5b 239 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 100 220 2.1E-22 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS36035 eaaf2af321bc82a302e5149f973bbf5b 239 SUPERFAMILY SSF55846 90 234 3.27E-41 T 17-03-2017 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 SHXM_RS02285 92822bbeddd28b3adc60d7786f83148a 88 Pfam PF13551 Winged helix-turn helix 4 62 1.2E-9 T 17-03-2017 SHXM_RS02285 92822bbeddd28b3adc60d7786f83148a 88 SUPERFAMILY SSF46689 3 78 5.5E-9 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS36885 a3149a5c195d65f42e7a33f440f50c02 189 SUPERFAMILY SSF55729 41 166 7.77E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS36885 a3149a5c195d65f42e7a33f440f50c02 189 Pfam PF00583 Acetyltransferase (GNAT) family 70 162 1.2E-8 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS36885 a3149a5c195d65f42e7a33f440f50c02 189 Gene3D G3DSA:3.40.630.30 21 166 5.2E-16 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS16445 6842567bb1011069494d58e622b3a12f 322 Pfam PF01040 UbiA prenyltransferase family 57 286 1.4E-20 T 17-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SHXM_RS34640 76afc196e5b49427bef1c5e4b6830e39 181 Pfam PF00583 Acetyltransferase (GNAT) family 62 140 1.9E-14 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS34640 76afc196e5b49427bef1c5e4b6830e39 181 SUPERFAMILY SSF55729 1 154 3.71E-35 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS34640 76afc196e5b49427bef1c5e4b6830e39 181 Gene3D G3DSA:3.40.630.30 2 160 4.0E-56 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS19780 ef04c7cfb4c214fb92ee8257e4a82ded 366 SUPERFAMILY SSF48208 33 347 4.08E-36 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS19780 ef04c7cfb4c214fb92ee8257e4a82ded 366 Gene3D G3DSA:1.50.10.20 26 234 1.1E-14 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS19780 ef04c7cfb4c214fb92ee8257e4a82ded 366 Gene3D G3DSA:1.50.10.20 274 342 1.1E-14 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS18810 f0a069fe15d04c40e3cbd872b75a4fde 253 SUPERFAMILY SSF56300 1 46 4.24E-34 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18810 f0a069fe15d04c40e3cbd872b75a4fde 253 SUPERFAMILY SSF56300 83 244 4.24E-34 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18810 f0a069fe15d04c40e3cbd872b75a4fde 253 Gene3D G3DSA:3.60.21.10 84 244 5.4E-21 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18810 f0a069fe15d04c40e3cbd872b75a4fde 253 Gene3D G3DSA:3.60.21.10 1 34 5.4E-21 T 17-03-2017 IPR029052 Metallo-dependent phosphatase-like SHXM_RS18810 f0a069fe15d04c40e3cbd872b75a4fde 253 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain 1 242 6.6E-9 T 17-03-2017 IPR024654 Calcineurin-like phosphoesterase domain, lpxH type Reactome: R-HSA-3238698 SHXM_RS18040 938421b28731b09b52a72557727b1b92 156 SUPERFAMILY SSF50118 49 155 1.61E-9 T 17-03-2017 IPR011067 Plasmid maintenance toxin/Cell growth inhibitor SHXM_RS18040 938421b28731b09b52a72557727b1b92 156 Pfam PF02452 PemK-like, MazF-like toxin of type II toxin-antitoxin system 51 150 2.8E-10 T 17-03-2017 IPR003477 mRNA interferase PemK-like protein GO:0003677 SHXM_RS04620 1736009eb35472875d6268da6dafd153 402 Pfam PF16483 Beta-1,3-glucanase 41 398 1.8E-105 T 17-03-2017 IPR032477 Beta-1,3-glucanase, N-terminal KEGG: 00500+3.2.1.39 SHXM_RS12645 999ed25bd8e85676daebb60763093169 211 Pfam PF04854 Protein of unknown function, DUF624 40 108 4.1E-5 T 17-03-2017 IPR006938 Protein of unknown function DUF624 SHXM_RS19185 04b8bfde5f3ce010ee1ad1c371421d5f 123 SUPERFAMILY SSF55331 2 121 3.11E-25 T 17-03-2017 IPR014347 Tautomerase/MIF superfamily SHXM_RS19185 04b8bfde5f3ce010ee1ad1c371421d5f 123 Pfam PF02962 5-carboxymethyl-2-hydroxymuconate isomerase 2 92 1.1E-5 T 17-03-2017 IPR004220 5-carboxymethyl-2-hydroxymuconate isomerase GO:0008704|GO:0019439 KEGG: 00350+5.3.3.10 SHXM_RS19185 04b8bfde5f3ce010ee1ad1c371421d5f 123 Gene3D G3DSA:3.30.429.10 1 122 8.2E-31 T 17-03-2017 SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 Gene3D G3DSA:1.10.150.120 81 163 1.4E-29 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 Pfam PF00111 2Fe-2S iron-sulfur cluster binding domain 12 73 2.4E-5 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 SUPERFAMILY SSF54292 9 93 1.57E-24 T 17-03-2017 IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domain GO:0009055|GO:0051536 SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 Gene3D G3DSA:3.10.20.30 9 80 1.1E-28 T 17-03-2017 IPR012675 Beta-grasp domain SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 SUPERFAMILY SSF47741 90 159 9.55E-27 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 Pfam PF01799 [2Fe-2S] binding domain 79 151 2.5E-26 T 17-03-2017 IPR002888 [2Fe-2S]-binding GO:0016491|GO:0046872|GO:0055114 SHXM_RS01355 f22d5f0bfe035eb80ea4aa24719ae781 171 ProSitePatterns PS00197 2Fe-2S ferredoxin-type iron-sulfur binding region signature. 45 53 - T 17-03-2017 IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site GO:0051537 SHXM_RS30630 2f4c822abafd45e0b6f09756eadc91cf 159 Pfam PF13396 Phospholipase_D-nuclease N-terminal 12 57 1.9E-12 T 17-03-2017 IPR027379 Cardiolipin synthase N-terminal SHXM_RS13985 7babc2b72bf42086556fbfb2ffd1adab 246 SUPERFAMILY SSF161098 3 246 6.93E-63 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13985 7babc2b72bf42086556fbfb2ffd1adab 246 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 63 236 2.2E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS13985 7babc2b72bf42086556fbfb2ffd1adab 246 Gene3D G3DSA:1.10.3720.10 10 233 1.5E-53 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS24175 0149f3425cd6843eee12ed40a2fe45ac 435 SUPERFAMILY SSF53697 226 430 7.11E-26 T 17-03-2017 SHXM_RS24175 0149f3425cd6843eee12ed40a2fe45ac 435 SUPERFAMILY SSF53697 91 203 3.56E-12 T 17-03-2017 SHXM_RS24175 0149f3425cd6843eee12ed40a2fe45ac 435 Pfam PF10432 Bacterial phospho-glucose isomerase C-terminal SIS domain 284 430 4.7E-17 T 17-03-2017 IPR019490 Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase, C-terminal GO:0004347|GO:0004476|GO:0005975 KEGG: 00010+5.3.1.9|KEGG: 00030+5.3.1.9|KEGG: 00051+5.3.1.8|KEGG: 00500+5.3.1.9|KEGG: 00520+5.3.1.8+5.3.1.9|MetaCyc: PWY-3801|MetaCyc: PWY-3861|MetaCyc: PWY-3881|MetaCyc: PWY-5054|MetaCyc: PWY-5384|MetaCyc: PWY-5514|MetaCyc: PWY-5659|MetaCyc: PWY-6142|MetaCyc: PWY-621|MetaCyc: PWY-622|MetaCyc: PWY-6981|MetaCyc: PWY-6992|MetaCyc: PWY-7238|MetaCyc: PWY-7347|MetaCyc: PWY-7385|MetaCyc: PWY-7456|MetaCyc: PWY-7586|MetaCyc: PWY-882 SHXM_RS12905 394cb37cf09f20439ff6cfbb9162e227 246 Pfam PF02424 ApbE family 92 222 8.8E-36 T 17-03-2017 IPR024932 Flavin transferase ApbE GO:0017013 SHXM_RS12905 394cb37cf09f20439ff6cfbb9162e227 246 Pfam PF02424 ApbE family 1 84 3.9E-7 T 17-03-2017 IPR024932 Flavin transferase ApbE GO:0017013 SHXM_RS12905 394cb37cf09f20439ff6cfbb9162e227 246 SUPERFAMILY SSF143631 1 240 1.05E-55 T 17-03-2017 IPR003374 ApbE-like domain SHXM_RS50870 03bc8f3e5250aaae8a6e134b42def460 167 Pfam PF14464 Prokaryotic homologs of the JAB domain 18 134 1.4E-12 T 17-03-2017 IPR028090 JAB domain, prokaryotic SHXM_RS50870 03bc8f3e5250aaae8a6e134b42def460 167 SUPERFAMILY SSF102712 16 146 3.79E-11 T 17-03-2017 SHXM_RS50870 03bc8f3e5250aaae8a6e134b42def460 167 Gene3D G3DSA:3.40.140.10 13 143 4.1E-8 T 17-03-2017 SHXM_RS49455 32bdaed6db83e136b15eaa07b7202e2a 501 Pfam PF00474 Sodium:solute symporter family 34 429 5.5E-26 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS28775 315ca46e743738575ca6dddab96bbb68 399 Gene3D G3DSA:1.10.260.40 8 65 1.3E-12 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28775 315ca46e743738575ca6dddab96bbb68 399 Pfam PF13560 Helix-turn-helix domain 8 62 1.2E-9 T 17-03-2017 SHXM_RS28775 315ca46e743738575ca6dddab96bbb68 399 SUPERFAMILY SSF47413 6 69 2.79E-11 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS28775 315ca46e743738575ca6dddab96bbb68 399 SMART SM00530 11 64 1.2E-8 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS28775 315ca46e743738575ca6dddab96bbb68 399 Gene3D G3DSA:1.25.40.10 182 241 2.0E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS28775 315ca46e743738575ca6dddab96bbb68 399 Gene3D G3DSA:1.25.40.10 293 323 2.0E-4 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS09825 74fe9952f6237aabf95cdab10700cc4a 63 Pfam PF13276 HTH-like domain 8 54 1.2E-11 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS49660 570f3dbd6aa9775bc502cdb31c66f842 258 Pfam PF13520 Amino acid permease 25 236 7.0E-13 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS15175 025c08603d4022b63f800a60bbb6851f 294 SMART SM00530 6 83 2.3E-4 T 17-03-2017 IPR001387 Cro/C1-type helix-turn-helix domain GO:0043565 SHXM_RS15175 025c08603d4022b63f800a60bbb6851f 294 Pfam PF13560 Helix-turn-helix domain 11 86 5.5E-12 T 17-03-2017 SHXM_RS15175 025c08603d4022b63f800a60bbb6851f 294 Gene3D G3DSA:1.10.260.40 5 82 2.5E-14 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS15175 025c08603d4022b63f800a60bbb6851f 294 SUPERFAMILY SSF47413 32 80 6.68E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS23260 ac6368cf586698dadf8ec3aa340694a8 242 Pfam PF04203 Sortase family 84 224 1.5E-15 T 17-03-2017 IPR005754 Sortase family SHXM_RS23260 ac6368cf586698dadf8ec3aa340694a8 242 Gene3D G3DSA:2.40.260.10 83 218 2.5E-7 T 17-03-2017 IPR023365 Sortase domain SHXM_RS23260 ac6368cf586698dadf8ec3aa340694a8 242 SUPERFAMILY SSF63817 72 225 7.06E-14 T 17-03-2017 IPR023365 Sortase domain SHXM_RS48270 f73bd8102a084733baab5c6381f7d674 394 Pfam PF03601 Conserved hypothetical protein 698 68 373 2.3E-74 T 17-03-2017 IPR018383 Uncharacterised protein family UPF0324, prokaryote GO:0016021 SHXM_RS19255 1aba33fa056fcf2502861aaf85d684fa 110 SUPERFAMILY SSF54909 1 94 7.26E-30 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS19255 1aba33fa056fcf2502861aaf85d684fa 110 Gene3D G3DSA:3.30.70.900 1 92 1.7E-26 T 17-03-2017 SHXM_RS19255 1aba33fa056fcf2502861aaf85d684fa 110 Pfam PF03992 Antibiotic biosynthesis monooxygenase 1 76 6.1E-22 T 17-03-2017 IPR007138 Antibiotic biosynthesis monooxygenase domain SHXM_RS43560 08cbf280ed1c6b4034f402d5353bd1da 317 Pfam PF09995 Uncharacterized protein conserved in bacteria (DUF2236) 25 256 3.0E-54 T 17-03-2017 IPR018713 Domain of unknown function DUF2236 SHXM_RS26790 aed8e5166f7dc4f2dd1347e36c08d206 700 SUPERFAMILY SSF52540 252 427 7.1E-9 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS26790 aed8e5166f7dc4f2dd1347e36c08d206 700 Gene3D G3DSA:3.40.50.300 250 426 1.4E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24810 2b1a456991c6701191c7a288be88c1c1 68 Pfam PF04024 PspC domain 5 59 4.0E-18 T 17-03-2017 IPR007168 Phage shock protein, PspC, N-terminal SHXM_RS05700 bc3f140f11958d992dc5a9623b43818f 311 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 124 141 5.0E-15 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS05700 bc3f140f11958d992dc5a9623b43818f 311 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 70 81 5.0E-15 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS05700 bc3f140f11958d992dc5a9623b43818f 311 PRINTS PR00725 D-Ala-D-Ala carboxypeptidase 1 (S11) family signature 157 170 5.0E-15 T 17-03-2017 IPR018044 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A GO:0006508|GO:0009002 SHXM_RS05700 bc3f140f11958d992dc5a9623b43818f 311 Gene3D G3DSA:3.40.710.10 39 294 1.5E-80 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS05700 bc3f140f11958d992dc5a9623b43818f 311 Pfam PF00768 D-alanyl-D-alanine carboxypeptidase 35 278 5.5E-47 T 17-03-2017 IPR001967 Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, N-terminal GO:0006508|GO:0009002 SHXM_RS05700 bc3f140f11958d992dc5a9623b43818f 311 SUPERFAMILY SSF56601 40 293 1.02E-57 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS40225 e3d6a094265d2f24395e50e7c4468361 46 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 2 30 1.1E-4 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 SUPERFAMILY SSF51735 28 282 3.47E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 Pfam PF00106 short chain dehydrogenase 33 227 3.4E-22 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 Gene3D G3DSA:3.40.50.720 24 263 1.1E-41 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 146 162 2.9E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 102 113 2.9E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 32 49 2.9E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS44245 d1e30f7e43cadbd0f46c793a1e8479b1 323 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 206 223 2.9E-10 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS05240 9c464980131766c8c65a1910516338f1 383 SUPERFAMILY SSF55874 250 349 8.63E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS05240 9c464980131766c8c65a1910516338f1 383 Pfam PF07730 Histidine kinase 169 236 6.6E-15 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS44275 9ddb3bf504b9b1f50c5a0653b3681c92 121 Pfam PF09862 Protein of unknown function (DUF2089) 12 117 4.3E-28 T 17-03-2017 IPR018658 Protein of unknown function DUF2089 SHXM_RS24060 4514c84e20863ef39df115947b92d17c 222 SUPERFAMILY SSF56784 7 212 4.72E-31 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS24060 4514c84e20863ef39df115947b92d17c 222 Gene3D G3DSA:3.40.50.1000 4 20 1.6E-20 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS24060 4514c84e20863ef39df115947b92d17c 222 Gene3D G3DSA:3.40.50.1000 92 217 1.6E-20 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS24060 4514c84e20863ef39df115947b92d17c 222 Pfam PF13242 HAD-hyrolase-like 148 212 9.6E-10 T 17-03-2017 SHXM_RS15015 05d905ed1d1d2f4ed5557f647d67824b 135 SUPERFAMILY SSF82784 4 111 5.23E-31 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS15015 05d905ed1d1d2f4ed5557f647d67824b 135 Pfam PF02566 OsmC-like protein 20 110 1.7E-16 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS15015 05d905ed1d1d2f4ed5557f647d67824b 135 Gene3D G3DSA:3.30.300.20 1 113 4.5E-35 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS12245 4b42df73b0942d8ddf200a6b9601f631 490 PIRSF PIRSF006060 36 488 2.5E-91 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS12245 4b42df73b0942d8ddf200a6b9601f631 490 Pfam PF13520 Amino acid permease 53 458 6.7E-55 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS12245 4b42df73b0942d8ddf200a6b9601f631 490 TIGRFAM TIGR00909 2A0306: amino acid transporter 48 478 6.8E-177 T 17-03-2017 IPR004758 Amino acid transporter SHXM_RS21305 c1dd5a6933461b8c1f57449e0d0b7948 272 Pfam PF11296 Protein of unknown function (DUF3097) 5 269 1.0E-127 T 17-03-2017 IPR021447 Protein of unknown function DUF3097 SHXM_RS02655 96377d48e2f71ef49186c007cdcdd616 199 Gene3D G3DSA:1.10.10.10 48 183 1.0E-32 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02655 96377d48e2f71ef49186c007cdcdd616 199 PRINTS PR00598 Bacterial regulatory protein MarR family signature 113 128 7.3E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02655 96377d48e2f71ef49186c007cdcdd616 199 PRINTS PR00598 Bacterial regulatory protein MarR family signature 132 148 7.3E-8 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02655 96377d48e2f71ef49186c007cdcdd616 199 SUPERFAMILY SSF46785 51 184 4.23E-29 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS02655 96377d48e2f71ef49186c007cdcdd616 199 Pfam PF01047 MarR family 79 136 5.4E-14 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS02655 96377d48e2f71ef49186c007cdcdd616 199 SMART SM00347 72 172 1.3E-21 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS09470 2cb4912403feaea35b1574817a3a55f8 110 Gene3D G3DSA:3.30.420.10 1 74 3.3E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09470 2cb4912403feaea35b1574817a3a55f8 110 SUPERFAMILY SSF53098 1 77 9.48E-8 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09470 2cb4912403feaea35b1574817a3a55f8 110 Pfam PF13683 Integrase core domain 9 73 7.6E-9 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS21690 609242a1d5672e16fee775c1a493d9fd 281 SUPERFAMILY SSF81995 5 77 1.65E-5 T 17-03-2017 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 Hamap MF_00444 ATP-dependent Clp protease proteolytic subunit [clpP]. 5 196 36.724 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 PRINTS PR00127 Clp protease catalytic subunit P signature 92 109 8.0E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 PRINTS PR00127 Clp protease catalytic subunit P signature 61 81 8.0E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 PRINTS PR00127 Clp protease catalytic subunit P signature 171 190 8.0E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 PRINTS PR00127 Clp protease catalytic subunit P signature 21 36 8.0E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 PRINTS PR00127 Clp protease catalytic subunit P signature 113 132 8.0E-41 T 17-03-2017 IPR001907 ATP-dependent Clp protease proteolytic subunit GO:0004252|GO:0006508 SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 Pfam PF00574 Clp protease 15 195 4.6E-70 T 17-03-2017 IPR023562 Clp protease proteolytic subunit /Translocation-enhancing protein TepA SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 Gene3D G3DSA:3.90.226.10 6 195 1.4E-69 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS20050 4772d7a63ed7711b14d193eff189a0ac 201 SUPERFAMILY SSF52096 5 195 5.42E-59 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS45210 75dfb39d66bc19288b720a57e595cb9e 192 Pfam PF14065 Protein of unknown function (DUF4255) 9 181 1.2E-37 T 17-03-2017 IPR025351 Protein of unknown function DUF4255 SHXM_RS03195 167edc690fc278318ffee871acd41a9f 405 Pfam PF09594 Protein of unknown function (DUF2029) 68 304 1.1E-57 T 17-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 SHXM_RS48515 57b16ed2f57c0d99ca0d9d0b0ce8ad65 333 Pfam PF02653 Branched-chain amino acid transport system / permease component 47 312 2.5E-47 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 SUPERFAMILY SSF50331 1 69 1.34E-17 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 Gene3D G3DSA:2.40.50.100 1 67 2.5E-21 T 17-03-2017 SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 Gene3D G3DSA:2.40.50.100 74 138 1.9E-23 T 17-03-2017 SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 Pfam PF03459 TOBE domain 75 136 2.2E-18 T 17-03-2017 IPR005116 Transport-associated OB, type 1 SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 Pfam PF03459 TOBE domain 4 66 3.9E-15 T 17-03-2017 IPR005116 Transport-associated OB, type 1 SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 SUPERFAMILY SSF50331 74 139 4.89E-19 T 17-03-2017 IPR008995 Molybdate/tungstate binding, C-terminal SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 TIGRFAM TIGR00638 Mop: molybdenum-pterin binding domain 74 139 3.0E-20 T 17-03-2017 IPR004606 Molybdenum-pterin binding GO:0006810|GO:0030151 SHXM_RS27065 2c7b52d26ebc21c1245100f0fb092c1b 140 TIGRFAM TIGR00638 Mop: molybdenum-pterin binding domain 1 68 1.3E-17 T 17-03-2017 IPR004606 Molybdenum-pterin binding GO:0006810|GO:0030151 SHXM_RS01710 d604206be0806167054e16de34583430 125 Pfam PF13564 DoxX-like family 8 115 1.3E-25 T 17-03-2017 IPR032808 DoxX family SHXM_RS44590 50dd5b6bef231853e56853dabff9d8fd 129 Pfam PF02924 Bacteriophage lambda head decoration protein D 19 116 1.9E-10 T 17-03-2017 IPR004195 Head decoration protein D GO:0019028 SHXM_RS32595 2a59d0b9b3121a2f23e89b50e6532179 71 Pfam PF04149 Domain of unknown function (DUF397) 11 64 2.1E-25 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS03015 ab68a6b2fc950a57497af637f2e0881e 337 Pfam PF14518 Iron-containing redox enzyme 139 314 5.9E-43 T 17-03-2017 IPR028201 PqqC-like protein SHXM_RS03015 ab68a6b2fc950a57497af637f2e0881e 337 SUPERFAMILY SSF48613 135 304 1.56E-6 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS03015 ab68a6b2fc950a57497af637f2e0881e 337 SMART SM01236 171 276 1.8E-31 T 17-03-2017 SHXM_RS03015 ab68a6b2fc950a57497af637f2e0881e 337 Gene3D G3DSA:1.20.910.10 122 331 2.1E-54 T 17-03-2017 IPR016084 Haem oxygenase-like, multi-helical Reactome: R-HSA-189483|Reactome: R-HSA-917937 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 SUPERFAMILY SSF51905 471 509 2.53E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 SUPERFAMILY SSF51905 2 312 2.53E-48 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 Pfam PF01593 Flavin containing amine oxidoreductase 14 298 1.0E-20 T 17-03-2017 IPR002937 Amine oxidase GO:0016491|GO:0055114 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 Gene3D G3DSA:3.50.50.60 222 316 1.2E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 Gene3D G3DSA:3.50.50.60 2 80 1.2E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 Gene3D G3DSA:3.50.50.60 458 510 1.2E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS18660 62a07ae66ddb1ccdbdb0ca9ddc9654fc 518 Gene3D G3DSA:3.50.50.60 130 132 1.2E-31 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS07085 12e022ce8940b3b1a364c3a762432907 253 Pfam PF07848 PaaX-like protein 20 80 7.0E-13 T 17-03-2017 IPR012906 PaaX-like, N-terminal SHXM_RS07085 12e022ce8940b3b1a364c3a762432907 253 Pfam PF08223 PaaX-like protein C-terminal domain 98 241 2.2E-12 T 17-03-2017 IPR013225 PaaX-like, C-terminal SHXM_RS47480 1ab5a97ad861957f052b4e463cd509c1 80 Pfam PF00890 FAD binding domain 12 45 2.6E-8 T 17-03-2017 IPR003953 FAD-dependent oxidoreductase 2, FAD binding domain Reactome: R-HSA-611105|Reactome: R-HSA-71403 SHXM_RS47480 1ab5a97ad861957f052b4e463cd509c1 80 SUPERFAMILY SSF51905 8 78 1.55E-9 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS47480 1ab5a97ad861957f052b4e463cd509c1 80 Gene3D G3DSA:3.50.50.60 11 78 4.2E-12 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS16215 62fb77d18a9f0e944a47822bc131b062 278 Gene3D G3DSA:3.40.50.150 15 137 1.5E-8 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS16215 62fb77d18a9f0e944a47822bc131b062 278 SUPERFAMILY SSF53335 24 141 1.99E-10 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS02795 d22bce7d447e5bc1130d4e596e8d5547 316 SUPERFAMILY SSF56219 100 314 2.88E-20 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS02795 d22bce7d447e5bc1130d4e596e8d5547 316 Pfam PF03372 Endonuclease/Exonuclease/phosphatase family 106 306 5.3E-13 T 17-03-2017 IPR005135 Endonuclease/exonuclease/phosphatase SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00400 Tetracycline repressor protein signature 20 43 8.7E-19 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00400 Tetracycline repressor protein signature 71 90 8.7E-19 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00400 Tetracycline repressor protein signature 91 114 8.7E-19 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00400 Tetracycline repressor protein signature 127 146 8.7E-19 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00400 Tetracycline repressor protein signature 185 199 8.7E-19 T 17-03-2017 IPR003012 Tetracycline transcriptional regulator, TetR GO:0045892|GO:0046677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 Pfam PF02909 Tetracyclin repressor, C-terminal all-alpha domain 65 200 2.3E-28 T 17-03-2017 IPR004111 Tetracycline transcriptional regulator, TetR, C-terminal GO:0045892 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 SUPERFAMILY SSF46689 2 60 5.99E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 Gene3D G3DSA:1.10.357.10 62 203 4.6E-35 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 Gene3D G3DSA:1.10.10.60 2 60 1.1E-21 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 29 52 9.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 8 21 9.2E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 SUPERFAMILY SSF48498 65 206 7.67E-32 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS41870 8d6dfa8a93d823c89105805c9dd14c86 218 Pfam PF00440 Bacterial regulatory proteins, tetR family 9 54 2.1E-13 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS43155 2e83c50d2090b8bb81234b431327397b 127 Pfam PF09851 Short C-terminal domain 98 125 1.4E-6 T 17-03-2017 IPR018649 SHOCT domain SHXM_RS43155 2e83c50d2090b8bb81234b431327397b 127 Pfam PF13396 Phospholipase_D-nuclease N-terminal 19 65 4.3E-7 T 17-03-2017 IPR027379 Cardiolipin synthase N-terminal SHXM_RS45470 cc25a8bb46cfe91e443fec7ad5868445 235 SUPERFAMILY SSF141571 40 196 9.42E-33 T 17-03-2017 SHXM_RS45470 cc25a8bb46cfe91e443fec7ad5868445 235 Pfam PF00805 Pentapeptide repeats (8 copies) 132 169 2.0E-8 T 17-03-2017 IPR001646 Pentapeptide repeat SHXM_RS45470 cc25a8bb46cfe91e443fec7ad5868445 235 Pfam PF00805 Pentapeptide repeats (8 copies) 73 103 1.4E-5 T 17-03-2017 IPR001646 Pentapeptide repeat SHXM_RS43255 20d8633e111ce0b9955f10156dab9cde 97 Pfam PF09851 Short C-terminal domain 59 84 2.6E-6 T 17-03-2017 IPR018649 SHOCT domain SHXM_RS05195 f19f9dfc00c8f27a8a108e6c4fb34b84 284 Gene3D G3DSA:3.40.390.10 175 282 1.6E-8 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS05195 f19f9dfc00c8f27a8a108e6c4fb34b84 284 SUPERFAMILY SSF55486 179 277 9.87E-7 T 17-03-2017 SHXM_RS31000 23b3c6dba7fc340995e68c16418fbda0 142 SUPERFAMILY SSF81330 10 111 3.79E-19 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS31000 23b3c6dba7fc340995e68c16418fbda0 142 Pfam PF01741 Large-conductance mechanosensitive channel, MscL 2 101 9.8E-24 T 17-03-2017 IPR001185 Large-conductance mechanosensitive channel GO:0005216|GO:0006810|GO:0016021 SHXM_RS21820 e8737d79633ee765345307363ff3b918 197 Pfam PF02632 BioY family 52 191 4.8E-33 T 17-03-2017 IPR003784 BioY protein GO:0005886|GO:0015225|GO:0015878 SHXM_RS21820 e8737d79633ee765345307363ff3b918 197 PIRSF PIRSF016661 13 196 4.4E-39 T 17-03-2017 IPR003784 BioY protein GO:0005886|GO:0015225|GO:0015878 SHXM_RS44840 e5d1eb475cde6073b2b0e6db275bd185 511 Pfam PF03806 AbgT putative transporter family 6 510 8.3E-160 T 17-03-2017 IPR004697 p-aminobenzoyl-glutamate transport protein AbgT GO:0015558|GO:1902604 SHXM_RS25335 d07787ef5ae4155bbcb955deb1d8397c 264 SUPERFAMILY SSF53474 52 195 7.21E-27 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS25335 d07787ef5ae4155bbcb955deb1d8397c 264 Pfam PF00561 alpha/beta hydrolase fold 104 158 3.5E-8 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS25335 d07787ef5ae4155bbcb955deb1d8397c 264 Gene3D G3DSA:3.40.50.1820 52 255 2.6E-33 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39090 d1a90ce287614b3ab4d4d32d1291b6e5 329 SUPERFAMILY SSF53822 46 319 1.1E-46 T 17-03-2017 IPR028082 Periplasmic binding protein-like I SHXM_RS39090 d1a90ce287614b3ab4d4d32d1291b6e5 329 Gene3D G3DSA:3.40.50.2300 41 164 2.8E-29 T 17-03-2017 SHXM_RS39090 d1a90ce287614b3ab4d4d32d1291b6e5 329 Pfam PF13407 Periplasmic binding protein domain 48 290 2.2E-37 T 17-03-2017 IPR025997 Periplasmic binding protein SHXM_RS39090 d1a90ce287614b3ab4d4d32d1291b6e5 329 Gene3D G3DSA:3.40.50.2300 165 289 3.4E-14 T 17-03-2017 SHXM_RS49270 91b5c406913e8ce5b5429f34ecc60396 195 Pfam PF10686 Protein of unknown function (DUF2493) 7 65 8.8E-8 T 17-03-2017 IPR019627 Mycobacteriophage D29, Gp61 SHXM_RS41520 f49a3c9efaa8621341954000188e6f57 192 Gene3D G3DSA:1.10.357.10 7 166 2.3E-26 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS41520 f49a3c9efaa8621341954000188e6f57 192 Pfam PF00440 Bacterial regulatory proteins, tetR family 22 64 9.7E-9 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS41520 f49a3c9efaa8621341954000188e6f57 192 SUPERFAMILY SSF46689 10 89 5.49E-13 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS41520 f49a3c9efaa8621341954000188e6f57 192 SUPERFAMILY SSF48498 92 166 1.74E-5 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS22480 7dd09522fcdb6e5658aed594b5ccdec4 406 TIGRFAM TIGR01426 MGT: glycosyltransferase, MGT family 16 404 1.6E-122 T 17-03-2017 IPR006326 UDP-glycosyltransferase, MGT GO:0016758|GO:0016999 SHXM_RS22480 7dd09522fcdb6e5658aed594b5ccdec4 406 SUPERFAMILY SSF53756 12 402 1.18E-79 T 17-03-2017 SHXM_RS22480 7dd09522fcdb6e5658aed594b5ccdec4 406 Gene3D G3DSA:3.40.50.2000 12 244 1.5E-14 T 17-03-2017 SHXM_RS22480 7dd09522fcdb6e5658aed594b5ccdec4 406 Gene3D G3DSA:3.40.50.2000 245 387 2.2E-35 T 17-03-2017 SHXM_RS22480 7dd09522fcdb6e5658aed594b5ccdec4 406 ProSitePatterns PS00375 UDP-glycosyltransferases signature. 296 337 - T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS22480 7dd09522fcdb6e5658aed594b5ccdec4 406 Pfam PF00201 UDP-glucoronosyl and UDP-glucosyl transferase 237 374 2.5E-16 T 17-03-2017 IPR002213 UDP-glucuronosyl/UDP-glucosyltransferase GO:0008152|GO:0016758 SHXM_RS21770 381feaeed26e44fb84bd05238c6837b9 277 Gene3D G3DSA:3.40.50.1820 24 272 6.2E-43 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS21770 381feaeed26e44fb84bd05238c6837b9 277 SUPERFAMILY SSF53474 20 272 5.5E-24 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS39930 f7bc30682a697232bfd2df6d1b49d1c3 134 Pfam PF00571 CBS domain 31 70 1.5E-4 T 17-03-2017 IPR000644 CBS domain SHXM_RS39930 f7bc30682a697232bfd2df6d1b49d1c3 134 Gene3D G3DSA:3.10.580.10 22 130 5.8E-11 T 17-03-2017 SHXM_RS39930 f7bc30682a697232bfd2df6d1b49d1c3 134 SUPERFAMILY SSF54631 22 131 1.89E-12 T 17-03-2017 SHXM_RS30610 4954393c26142b86b776c264fabecaf3 205 ProSitePatterns PS00194 Thioredoxin family active site. 89 107 - T 17-03-2017 IPR017937 Thioredoxin, conserved site GO:0045454 SHXM_RS30610 4954393c26142b86b776c264fabecaf3 205 Pfam PF00578 AhpC/TSA family 63 183 3.6E-21 T 17-03-2017 IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant GO:0016209|GO:0016491|GO:0055114 KEGG: 00480+1.11.1.15|Reactome: R-HSA-3299685 SHXM_RS30610 4954393c26142b86b776c264fabecaf3 205 Gene3D G3DSA:3.40.30.10 17 204 2.9E-43 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS30610 4954393c26142b86b776c264fabecaf3 205 SUPERFAMILY SSF52833 63 204 7.74E-32 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS37300 6026721f1359aacd719b690c6f7fe72c 329 Gene3D G3DSA:3.40.190.10 123 260 2.8E-27 T 17-03-2017 SHXM_RS37300 6026721f1359aacd719b690c6f7fe72c 329 Pfam PF16868 NMT1-like family 46 325 3.4E-49 T 17-03-2017 IPR011852 TRAP transporter solute receptor, TAXI family SHXM_RS37300 6026721f1359aacd719b690c6f7fe72c 329 SUPERFAMILY SSF53850 42 325 2.97E-57 T 17-03-2017 SHXM_RS37300 6026721f1359aacd719b690c6f7fe72c 329 Gene3D G3DSA:3.40.190.10 261 325 9.1E-33 T 17-03-2017 SHXM_RS37300 6026721f1359aacd719b690c6f7fe72c 329 Gene3D G3DSA:3.40.190.10 43 121 9.1E-33 T 17-03-2017 SHXM_RS37300 6026721f1359aacd719b690c6f7fe72c 329 TIGRFAM TIGR02122 TRAP_TAXI: TRAP transporter solute receptor, TAXI family 13 327 6.1E-73 T 17-03-2017 IPR011852 TRAP transporter solute receptor, TAXI family SHXM_RS49225 2ced5862f130f8ffe5ef6428ff4402ca 196 Pfam PF01609 Transposase DDE domain 32 140 7.6E-14 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS11635 105ae645d61c63e1fa52dc8fa1fdb270 18 Gene3D G3DSA:2.130.10.10 1 18 1.0E-4 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS32380 115193510d0a7613d6ab69e2cc517b5d 380 Gene3D G3DSA:3.60.70.12 10 370 5.7E-93 T 17-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS32380 115193510d0a7613d6ab69e2cc517b5d 380 SUPERFAMILY SSF56266 10 224 3.92E-72 T 17-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS32380 115193510d0a7613d6ab69e2cc517b5d 380 SUPERFAMILY SSF56266 255 367 3.92E-72 T 17-03-2017 IPR016117 ArgJ-like domain KEGG: 00220+2.3.1.35+2.3.1.1|MetaCyc: PWY-5154 SHXM_RS32380 115193510d0a7613d6ab69e2cc517b5d 380 Pfam PF03576 Peptidase family S58 18 368 4.1E-71 T 17-03-2017 IPR005321 Peptidase S58, DmpA SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 Pfam PF00361 Proton-conducting membrane transporter 141 451 2.7E-67 T 17-03-2017 IPR001750 NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 TIGRFAM TIGR01972 NDH_I_M: proton-translocating NADH-quinone oxidoreductase, chain M 6 517 1.0E-175 T 17-03-2017 IPR010227 NADH-quinone oxidoreductase, chain M/4 GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 147 166 4.7E-28 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 188 212 4.7E-28 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 269 293 4.7E-28 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 357 376 4.7E-28 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS30815 5c39006dd8b950ec0af2fba400e8d144 554 PRINTS PR01437 NADH-ubiquinone oxidoreductase subunit 4 signature 409 435 4.7E-28 T 17-03-2017 IPR003918 NADH:ubiquinone oxidoreductase GO:0008137|GO:0042773|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS47610 976416b390edfab8fb2f47a779c88c7f 84 Pfam PF01526 Tn3 transposase DDE domain 1 74 2.0E-18 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS45645 a6362d9daec35c48c4604fe0b4385bb6 140 SUPERFAMILY SSF55331 2 57 2.17E-6 T 17-03-2017 IPR014347 Tautomerase/MIF superfamily SHXM_RS45645 a6362d9daec35c48c4604fe0b4385bb6 140 Gene3D G3DSA:3.30.429.10 1 140 9.4E-54 T 17-03-2017 SHXM_RS45645 a6362d9daec35c48c4604fe0b4385bb6 140 Pfam PF14832 Putative oxalocrotonate tautomerase enzyme 1 136 5.5E-50 T 17-03-2017 IPR028116 Putative oxalocrotonate tautomerase SHXM_RS20390 12bea483234cdf7c1c52aaa9b5aba136 410 Pfam PF02653 Branched-chain amino acid transport system / permease component 64 398 6.2E-46 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS30870 dc0ce06ebeb9208447b1c974fe902bc1 327 SMART SM00382 38 246 1.2E-10 T 17-03-2017 IPR003593 AAA+ ATPase domain SHXM_RS30870 dc0ce06ebeb9208447b1c974fe902bc1 327 ProSitePatterns PS00211 ABC transporters family signature. 146 160 - T 17-03-2017 IPR017871 ABC transporter, conserved site GO:0005524|GO:0016887 SHXM_RS30870 dc0ce06ebeb9208447b1c974fe902bc1 327 Pfam PF00005 ABC transporter 30 174 2.5E-25 T 17-03-2017 IPR003439 ABC transporter-like GO:0005524|GO:0016887 SHXM_RS30870 dc0ce06ebeb9208447b1c974fe902bc1 327 SUPERFAMILY SSF52540 12 234 2.37E-58 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS30870 dc0ce06ebeb9208447b1c974fe902bc1 327 Gene3D G3DSA:3.40.50.300 5 236 4.3E-65 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36345 e77d72a20e7d83c256bfe08c2c8e334c 154 Pfam PF13826 Domain of unknown function (DUF4188) 9 129 9.1E-42 T 17-03-2017 IPR025444 Protein of unknown function DUF4188 SHXM_RS49945 8aeb06c3c1b0330711c9428f7f50d125 151 Pfam PF00027 Cyclic nucleotide-binding domain 25 111 2.3E-11 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS49945 8aeb06c3c1b0330711c9428f7f50d125 151 Gene3D G3DSA:2.60.120.10 6 129 3.4E-16 T 17-03-2017 IPR014710 RmlC-like jelly roll fold SHXM_RS49945 8aeb06c3c1b0330711c9428f7f50d125 151 SMART SM00100 6 124 1.8E-5 T 17-03-2017 IPR000595 Cyclic nucleotide-binding domain SHXM_RS49945 8aeb06c3c1b0330711c9428f7f50d125 151 SUPERFAMILY SSF51206 6 130 5.63E-21 T 17-03-2017 IPR018490 Cyclic nucleotide-binding-like SHXM_RS04660 8568d11c40a61f2c8a49bfd4e7fe7989 284 SUPERFAMILY SSF88713 63 266 8.65E-38 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS04660 8568d11c40a61f2c8a49bfd4e7fe7989 284 Pfam PF01522 Polysaccharide deacetylase 76 197 8.9E-16 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS04660 8568d11c40a61f2c8a49bfd4e7fe7989 284 Gene3D G3DSA:3.20.20.370 71 267 3.0E-36 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS50500 8af88fe8ef7940ba62faa6a4cfa7cd79 287 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 99 280 1.1E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50500 8af88fe8ef7940ba62faa6a4cfa7cd79 287 Gene3D G3DSA:1.10.3720.10 3 274 2.3E-46 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50500 8af88fe8ef7940ba62faa6a4cfa7cd79 287 SUPERFAMILY SSF161098 4 286 5.61E-55 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS44740 e94bebce935eed9830b67a4267fb8c37 778 Pfam PF08453 Peptidase family M9 N-terminal 150 282 2.7E-11 T 17-03-2017 IPR013661 Peptidase M9, collagenase, N-terminal domain SHXM_RS44740 e94bebce935eed9830b67a4267fb8c37 778 Pfam PF01752 Collagenase 384 640 6.8E-47 T 17-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 SHXM_RS44740 e94bebce935eed9830b67a4267fb8c37 778 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 472 488 2.3E-16 T 17-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 SHXM_RS44740 e94bebce935eed9830b67a4267fb8c37 778 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 454 468 2.3E-16 T 17-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 SHXM_RS44740 e94bebce935eed9830b67a4267fb8c37 778 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 536 551 2.3E-16 T 17-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 SHXM_RS44740 e94bebce935eed9830b67a4267fb8c37 778 PRINTS PR00931 Microbial collagenase metalloprotease (M9) signature 510 528 2.3E-16 T 17-03-2017 IPR002169 Peptidase M9A/M9B, collagenase, bacterial GO:0004252|GO:0005576|GO:0006508|GO:0008270 SHXM_RS33700 4b00cc009ae6c827bfd6b7547366b469 260 Pfam PF13676 TIR domain 4 126 1.6E-14 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS33700 4b00cc009ae6c827bfd6b7547366b469 260 SUPERFAMILY SSF52200 2 109 3.92E-10 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS33700 4b00cc009ae6c827bfd6b7547366b469 260 Gene3D G3DSA:3.40.50.10140 3 111 4.9E-5 T 17-03-2017 IPR000157 Toll/interleukin-1 receptor homology (TIR) domain GO:0005515|GO:0007165 SHXM_RS04770 80135e1793e194d3eaf51b50b087854f 418 Gene3D G3DSA:3.40.640.10 82 290 1.9E-65 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS04770 80135e1793e194d3eaf51b50b087854f 418 SUPERFAMILY SSF53383 24 412 1.77E-94 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS04770 80135e1793e194d3eaf51b50b087854f 418 Gene3D G3DSA:3.90.1150.10 291 413 2.3E-12 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS04770 80135e1793e194d3eaf51b50b087854f 418 Pfam PF00155 Aminotransferase class I and II 48 404 4.0E-34 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 971 1005 1.1E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 720 757 1.3E-7 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 765 820 9.8E-7 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 1166 1195 1.0E-4 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 950 985 6.5E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 910 944 7.6E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 643 672 2.1E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 804 840 6.0E-6 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 846 883 2.8E-10 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 930 961 1.3E-4 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 678 714 1.2E-7 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 1085 1119 3.9E-7 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 Pfam PF05593 RHS Repeat 549 579 1.1E-4 T 17-03-2017 IPR031325 RHS repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 1306 1378 1.4E-19 T 17-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 910 943 6.6E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 641 671 9.6E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 528 567 1.7E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 846 887 3.4E-11 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1085 1117 5.9E-5 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 787 822 2.6E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1166 1198 4.2E-7 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 720 758 1.2E-9 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 992 1024 0.0015 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 950 991 5.1E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 1156 1185 1.7E-4 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 764 803 3.6E-4 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 678 719 3.5E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS17330 d53ff39f70137725af71a98dba4a99e9 1378 TIGRFAM TIGR01643 YD_repeat_2x: YD repeat (two copies) 888 928 6.9E-8 T 17-03-2017 IPR006530 YD repeat SHXM_RS06925 d78fa821e9bed02c6ccaf1202e67eb76 582 Pfam PF02836 Glycosyl hydrolases family 2, TIM barrel domain 100 257 1.2E-6 T 17-03-2017 IPR006103 Glycoside hydrolase family 2, catalytic domain GO:0004553|GO:0005975 KEGG: 00052+3.2.1.23|KEGG: 00511+3.2.1.23|KEGG: 00531+3.2.1.23|KEGG: 00600+3.2.1.23|KEGG: 00604+3.2.1.23|MetaCyc: PWY-6807 SHXM_RS06925 d78fa821e9bed02c6ccaf1202e67eb76 582 SUPERFAMILY SSF51445 39 337 1.21E-44 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS06925 d78fa821e9bed02c6ccaf1202e67eb76 582 Gene3D G3DSA:2.60.120.260 453 581 3.0E-30 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS06925 d78fa821e9bed02c6ccaf1202e67eb76 582 Gene3D G3DSA:3.20.20.80 47 337 1.5E-35 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS06925 d78fa821e9bed02c6ccaf1202e67eb76 582 Pfam PF00754 F5/8 type C domain 461 577 2.4E-27 T 17-03-2017 IPR000421 Coagulation factor 5/8 C-terminal domain SHXM_RS06925 d78fa821e9bed02c6ccaf1202e67eb76 582 SUPERFAMILY SSF49785 446 581 2.69E-30 T 17-03-2017 IPR008979 Galactose-binding domain-like SHXM_RS33675 7c5db3e0682f72828c2285fa3e022b1f 249 Gene3D G3DSA:3.30.420.40 1 103 3.4E-42 T 17-03-2017 SHXM_RS33675 7c5db3e0682f72828c2285fa3e022b1f 249 Pfam PF00480 ROK family 2 159 2.2E-24 T 17-03-2017 IPR000600 ROK family Reactome: R-HSA-4085001|Reactome: R-HSA-4085011 SHXM_RS33675 7c5db3e0682f72828c2285fa3e022b1f 249 Gene3D G3DSA:3.30.420.40 104 243 1.4E-38 T 17-03-2017 SHXM_RS33675 7c5db3e0682f72828c2285fa3e022b1f 249 SUPERFAMILY SSF53067 2 246 1.84E-43 T 17-03-2017 SHXM_RS47980 30906d1238e29b8d067cd502bae77378 215 Pfam PF00857 Isochorismatase family 12 193 6.3E-32 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS47980 30906d1238e29b8d067cd502bae77378 215 SUPERFAMILY SSF52499 7 206 6.54E-44 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS47980 30906d1238e29b8d067cd502bae77378 215 Gene3D G3DSA:3.40.50.850 5 207 1.7E-44 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS20965 37349e8cf08c5491e2206a1c823b666d 415 Gene3D G3DSA:3.40.50.1820 278 341 7.7E-6 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS20965 37349e8cf08c5491e2206a1c823b666d 415 SUPERFAMILY SSF53474 273 376 4.06E-7 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS07435 0f82192f288466cb2d9c239bb1df9105 272 PIRSF PIRSF017393 2 272 1.4E-101 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS07435 0f82192f288466cb2d9c239bb1df9105 272 Pfam PF04672 S-adenosyl methyltransferase 8 271 2.6E-110 T 17-03-2017 IPR006764 S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type SHXM_RS07435 0f82192f288466cb2d9c239bb1df9105 272 SUPERFAMILY SSF53335 15 262 5.99E-44 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS07435 0f82192f288466cb2d9c239bb1df9105 272 Gene3D G3DSA:3.40.50.150 6 271 2.2E-112 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS00155 f71359e12c5ecf2a89679773ca8c46d8 688 SUPERFAMILY SSF52980 281 334 1.93E-7 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS00155 f71359e12c5ecf2a89679773ca8c46d8 688 Pfam PF14311 Probable Zinc-ribbon domain 15 70 1.0E-9 T 17-03-2017 IPR025487 Probable Zinc-ribbon domain SHXM_RS00155 f71359e12c5ecf2a89679773ca8c46d8 688 Pfam PF14311 Probable Zinc-ribbon domain 102 161 1.0E-11 T 17-03-2017 IPR025487 Probable Zinc-ribbon domain SHXM_RS00155 f71359e12c5ecf2a89679773ca8c46d8 688 Pfam PF14311 Probable Zinc-ribbon domain 182 243 4.7E-10 T 17-03-2017 IPR025487 Probable Zinc-ribbon domain SHXM_RS00155 f71359e12c5ecf2a89679773ca8c46d8 688 Pfam PF03457 Helicase associated domain 408 467 1.1E-13 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50630 269b682b46cc66f95584cd2012495c5b 231 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 169 229 3.3E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50630 269b682b46cc66f95584cd2012495c5b 231 SMART SM00332 1 227 9.4E-4 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50630 269b682b46cc66f95584cd2012495c5b 231 SUPERFAMILY SSF81606 2 229 2.09E-23 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS50630 269b682b46cc66f95584cd2012495c5b 231 Gene3D G3DSA:3.60.40.10 2 228 1.2E-19 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS12580 7cdb0e5648a7d9bdd6d47a4fb1e5adb7 311 Pfam PF03279 Bacterial lipid A biosynthesis acyltransferase 7 290 1.8E-61 T 17-03-2017 IPR004960 Bacterial lipid A biosynthesis acyltransferase GO:0016021|GO:0016740 SHXM_RS15495 29c3031491fe4707227a3ace82769be8 160 SUPERFAMILY SSF52309 11 126 9.84E-14 T 17-03-2017 SHXM_RS15495 29c3031491fe4707227a3ace82769be8 160 Gene3D G3DSA:3.40.50.1810 32 115 1.3E-5 T 17-03-2017 IPR007710 Nucleoside 2-deoxyribosyltransferase GO:0009159|GO:0050144|GO:0070694 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 SUPERFAMILY SSF46689 212 259 1.79E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 Gene3D G3DSA:1.10.10.60 263 310 4.4E-14 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 Gene3D G3DSA:1.10.10.60 216 262 5.0E-18 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 SUPERFAMILY SSF46689 262 311 1.61E-11 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature. 262 304 - T 17-03-2017 IPR018062 HTH domain AraC-type, conserved site GO:0003700|GO:0006355|GO:0043565 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 SMART SM00342 225 308 1.1E-32 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 Pfam PF12833 Helix-turn-helix domain 231 309 1.4E-24 T 17-03-2017 IPR018060 DNA binding HTH domain, AraC-type GO:0003700|GO:0006355|GO:0043565 SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 SUPERFAMILY SSF52317 1 188 6.0E-45 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 Gene3D G3DSA:3.40.50.880 3 215 3.5E-48 T 17-03-2017 IPR029062 Class I glutamine amidotransferase-like SHXM_RS22890 0cb87231ce2fa7ea53cc55169e139760 316 Pfam PF01965 DJ-1/PfpI family 3 168 4.8E-17 T 17-03-2017 IPR002818 DJ-1/PfpI SHXM_RS09535 40e957d254637be40889a01d75732353 396 PIRSF PIRSF001434 1 391 5.6E-139 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS09535 40e957d254637be40889a01d75732353 396 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 8 387 5.9E-131 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS09535 40e957d254637be40889a01d75732353 396 Gene3D G3DSA:3.40.640.10 7 253 2.4E-93 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS09535 40e957d254637be40889a01d75732353 396 SUPERFAMILY SSF53383 24 388 7.43E-117 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS09535 40e957d254637be40889a01d75732353 396 Gene3D G3DSA:3.90.1150.10 254 388 1.6E-45 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS09380 40e957d254637be40889a01d75732353 396 PIRSF PIRSF001434 1 391 5.6E-139 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS09380 40e957d254637be40889a01d75732353 396 Pfam PF01053 Cys/Met metabolism PLP-dependent enzyme 8 387 5.9E-131 T 17-03-2017 IPR000277 Cys/Met metabolism, pyridoxal phosphate-dependent enzyme GO:0030170 Reactome: R-HSA-1614558|Reactome: R-HSA-1614603|Reactome: R-HSA-2408508 SHXM_RS09380 40e957d254637be40889a01d75732353 396 Gene3D G3DSA:3.40.640.10 7 253 2.4E-93 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS09380 40e957d254637be40889a01d75732353 396 SUPERFAMILY SSF53383 24 388 7.43E-117 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS09380 40e957d254637be40889a01d75732353 396 Gene3D G3DSA:3.90.1150.10 254 388 1.6E-45 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS11220 b62760ac151a8c78c6b07787d6b4844d 312 Gene3D G3DSA:1.10.3720.10 80 310 8.6E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11220 b62760ac151a8c78c6b07787d6b4844d 312 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 109 300 1.0E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS11220 b62760ac151a8c78c6b07787d6b4844d 312 SUPERFAMILY SSF161098 74 299 1.83E-48 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27425 b41d27ebc282150f028b57f952cc931e 292 Pfam PF00296 Luciferase-like monooxygenase 22 125 2.5E-13 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS27425 b41d27ebc282150f028b57f952cc931e 292 TIGRFAM TIGR03620 F420_MSMEG_4141: probable F420-dependent oxidoreductase, MSMEG_4141 family 7 287 8.3E-114 T 17-03-2017 IPR019922 Luciferase-like, F420-dependent oxidoreductase, MSMEG4141, predicted SHXM_RS27425 b41d27ebc282150f028b57f952cc931e 292 SUPERFAMILY SSF51679 10 268 2.49E-36 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS27425 b41d27ebc282150f028b57f952cc931e 292 Gene3D G3DSA:3.20.20.30 127 285 4.6E-12 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS27425 b41d27ebc282150f028b57f952cc931e 292 Gene3D G3DSA:3.20.20.30 10 126 1.7E-13 T 17-03-2017 IPR011251 Luciferase-like domain GO:0016705|GO:0055114 SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 Gene3D G3DSA:3.40.50.720 1 242 5.7E-71 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 Pfam PF13561 Enoyl-(Acyl carrier protein) reductase 16 242 2.5E-50 T 17-03-2017 SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 SUPERFAMILY SSF51735 5 243 6.77E-69 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 79 90 3.0E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 205 225 3.0E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 150 169 3.0E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 124 140 3.0E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 8 25 3.0E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS39780 fce09cb8c7294ea88c1a291e0a05bdcd 244 PRINTS PR00081 Glucose/ribitol dehydrogenase family signature 171 188 3.0E-25 T 17-03-2017 IPR002347 Short-chain dehydrogenase/reductase SDR SHXM_RS24195 963cc7ce145450afbd7a4017a640fcd8 151 Pfam PF12005 Protein of unknown function (DUF3499) 20 147 5.8E-47 T 17-03-2017 IPR021888 Protein of unknown function DUF3499 SHXM_RS16755 9f2dd11f9ad7c5d7afa4aa581c1a0411 92 Pfam PF00550 Phosphopantetheine attachment site 16 80 1.2E-6 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS16755 9f2dd11f9ad7c5d7afa4aa581c1a0411 92 Gene3D G3DSA:1.10.1200.10 10 83 7.9E-14 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS16755 9f2dd11f9ad7c5d7afa4aa581c1a0411 92 SUPERFAMILY SSF47336 14 87 4.84E-12 T 17-03-2017 IPR009081 Phosphopantetheine binding ACP domain SHXM_RS34920 8248ef3d96ae2cb843d7c97a0a1bc047 130 Pfam PF05331 Protein of unknown function (DUF742) 11 130 4.9E-38 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS19435 a2322db858a055bd2f872d5c9e61976a 451 Gene3D G3DSA:3.40.190.10 56 178 4.6E-13 T 17-03-2017 SHXM_RS19435 a2322db858a055bd2f872d5c9e61976a 451 Gene3D G3DSA:3.40.190.10 179 364 4.2E-36 T 17-03-2017 SHXM_RS19435 a2322db858a055bd2f872d5c9e61976a 451 Pfam PF01547 Bacterial extracellular solute-binding protein 63 346 1.6E-28 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS19435 a2322db858a055bd2f872d5c9e61976a 451 SUPERFAMILY SSF53850 34 444 1.52E-56 T 17-03-2017 SHXM_RS03330 5eca57bf6e833c37944fd5f6a0617d25 380 Pfam PF01384 Phosphate transporter family 22 163 7.8E-34 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS03330 5eca57bf6e833c37944fd5f6a0617d25 380 Pfam PF01384 Phosphate transporter family 164 320 1.8E-45 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS24775 219a4e6e8f80ee73a979e151b34fa7cf 450 SUPERFAMILY SSF103473 9 439 9.02E-78 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS24775 219a4e6e8f80ee73a979e151b34fa7cf 450 Pfam PF00083 Sugar (and other) transporter 54 435 5.1E-37 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS24775 219a4e6e8f80ee73a979e151b34fa7cf 450 Gene3D G3DSA:1.20.1250.20 259 437 1.3E-27 T 17-03-2017 SHXM_RS24775 219a4e6e8f80ee73a979e151b34fa7cf 450 Gene3D G3DSA:1.20.1250.20 17 208 9.7E-24 T 17-03-2017 SHXM_RS24775 219a4e6e8f80ee73a979e151b34fa7cf 450 ProSitePatterns PS00216 Sugar transport proteins signature 1. 76 93 - T 17-03-2017 IPR005829 Sugar transporter, conserved site GO:0005215|GO:0016021|GO:0055085 SHXM_RS04875 19827c2fe7a1db85a220045f1f1195cc 208 SUPERFAMILY SSF51197 33 203 3.02E-40 T 17-03-2017 SHXM_RS04875 19827c2fe7a1db85a220045f1f1195cc 208 Gene3D G3DSA:2.60.120.590 104 203 5.0E-16 T 17-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like SHXM_RS04875 19827c2fe7a1db85a220045f1f1195cc 208 Pfam PF13532 2OG-Fe(II) oxygenase superfamily 106 203 7.6E-13 T 17-03-2017 IPR027450 Alpha-ketoglutarate-dependent dioxygenase AlkB-like SHXM_RS45500 31effb6210ea1df102582e988a88d342 340 SUPERFAMILY SSF51735 4 156 2.13E-45 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45500 31effb6210ea1df102582e988a88d342 340 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 7 125 7.2E-17 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS45500 31effb6210ea1df102582e988a88d342 340 Gene3D G3DSA:3.30.360.10 145 327 1.4E-31 T 17-03-2017 SHXM_RS45500 31effb6210ea1df102582e988a88d342 340 SUPERFAMILY SSF55347 131 300 5.07E-28 T 17-03-2017 SHXM_RS45500 31effb6210ea1df102582e988a88d342 340 Gene3D G3DSA:3.40.50.720 3 144 1.1E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS45500 31effb6210ea1df102582e988a88d342 340 Pfam PF02894 Oxidoreductase family, C-terminal alpha/beta domain 139 234 3.8E-5 T 17-03-2017 IPR004104 Oxidoreductase, C-terminal GO:0008152|GO:0016491|GO:0055114 SHXM_RS17655 f0c2ed8f84064b1be46be893d461f8bc 299 Gene3D G3DSA:1.10.3720.10 26 286 2.9E-61 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS17655 f0c2ed8f84064b1be46be893d461f8bc 299 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 290 2.0E-16 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS17655 f0c2ed8f84064b1be46be893d461f8bc 299 SUPERFAMILY SSF161098 34 299 3.46E-65 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS15220 52511b15e8ea3b7617b8fc65fbab05fa 76 Gene3D G3DSA:1.10.10.10 16 56 1.6E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS42560 e53881dfffc4c177e61aea0c5faa5d36 88 Gene3D G3DSA:3.40.1410.10 31 81 2.3E-4 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS42560 e53881dfffc4c177e61aea0c5faa5d36 88 SUPERFAMILY SSF64288 29 82 8.95E-5 T 17-03-2017 IPR028978 Chorismate pyruvate-lyase/UbiC transcription regulator-associated domain SHXM_RS00050 4ad7ad3de8fe6ac5e37ae124ea6da175 547 Pfam PF00665 Integrase core domain 132 262 4.1E-8 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS10180 4ad7ad3de8fe6ac5e37ae124ea6da175 547 Pfam PF00665 Integrase core domain 132 262 4.1E-8 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS41750 a95bac24dbb978754426d971b7285747 343 Gene3D G3DSA:3.20.20.80 89 315 8.8E-13 T 17-03-2017 IPR013781 Glycoside hydrolase, catalytic domain GO:0005975 SHXM_RS41750 a95bac24dbb978754426d971b7285747 343 SUPERFAMILY SSF51445 59 315 6.44E-19 T 17-03-2017 IPR017853 Glycoside hydrolase superfamily SHXM_RS41750 a95bac24dbb978754426d971b7285747 343 Pfam PF00704 Glycosyl hydrolases family 18 112 237 2.8E-8 T 17-03-2017 IPR001223 Glycoside hydrolase family 18, catalytic domain GO:0004553|GO:0005975 SHXM_RS29895 7f87a025c3190378c74315d72c7b6814 82 Pfam PF04149 Domain of unknown function (DUF397) 10 63 4.7E-8 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS37985 e408dc058ddf3feda10dac65e4ebd0aa 164 SUPERFAMILY SSF55874 36 140 5.22E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37985 e408dc058ddf3feda10dac65e4ebd0aa 164 Gene3D G3DSA:3.30.565.10 38 130 6.0E-4 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37985 e408dc058ddf3feda10dac65e4ebd0aa 164 Pfam PF13581 Histidine kinase-like ATPase domain 19 137 1.6E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS32340 b029f492a552e522c7b253c5fc713364 370 Pfam PF14027 Protein of unknown function (DUF4243) 27 343 1.1E-37 T 17-03-2017 IPR025337 Domain of unknown function DUF4243 SHXM_RS12760 827d460b9ae402819e9878aaa7b5f331 410 Gene3D G3DSA:1.20.1250.20 235 405 7.6E-7 T 17-03-2017 SHXM_RS12760 827d460b9ae402819e9878aaa7b5f331 410 Gene3D G3DSA:1.20.1250.20 29 205 5.8E-17 T 17-03-2017 SHXM_RS12760 827d460b9ae402819e9878aaa7b5f331 410 SUPERFAMILY SSF103473 20 405 2.49E-41 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS12760 827d460b9ae402819e9878aaa7b5f331 410 Pfam PF07690 Major Facilitator Superfamily 31 281 1.0E-18 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS40395 307309bd2ab338d2a9fd897da4d10421 390 Pfam PF16483 Beta-1,3-glucanase 29 386 8.2E-103 T 17-03-2017 IPR032477 Beta-1,3-glucanase, N-terminal KEGG: 00500+3.2.1.39 SHXM_RS48345 cb0b39a1053519623b4885197618a8a9 320 SUPERFAMILY SSF161098 80 306 2.09E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48345 cb0b39a1053519623b4885197618a8a9 320 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 112 316 2.3E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS48345 cb0b39a1053519623b4885197618a8a9 320 Gene3D G3DSA:1.10.3720.10 40 309 2.2E-57 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12115 452d414780baa90486e8678df052e223 209 Gene3D G3DSA:3.40.50.300 14 171 5.6E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS12115 452d414780baa90486e8678df052e223 209 SUPERFAMILY SSF52540 18 164 6.87E-16 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS49370 4853bcb05d5bb4175bbebed9949bc83b 185 SUPERFAMILY SSF47413 24 75 3.02E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS49370 4853bcb05d5bb4175bbebed9949bc83b 185 Gene3D G3DSA:1.10.260.40 25 72 1.3E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS13690 715e0cf35444d9ac7635c94055ad09af 146 SUPERFAMILY SSF55874 40 141 1.12E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13690 715e0cf35444d9ac7635c94055ad09af 146 Pfam PF13581 Histidine kinase-like ATPase domain 22 138 4.9E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS49705 3f06d08defa5c58a42539238d5286f4e 280 Gene3D G3DSA:2.60.120.620 4 216 3.3E-56 T 17-03-2017 SHXM_RS49705 3f06d08defa5c58a42539238d5286f4e 280 SUPERFAMILY SSF51197 1 254 7.14E-61 T 17-03-2017 SHXM_RS49705 3f06d08defa5c58a42539238d5286f4e 280 Pfam PF05721 Phytanoyl-CoA dioxygenase (PhyH) 13 203 1.0E-30 T 17-03-2017 IPR008775 Phytanoyl-CoA dioxygenase SHXM_RS08185 35300e20d6125e3b864e3e681148815f 225 Pfam PF13419 Haloacid dehalogenase-like hydrolase 14 192 1.1E-22 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS08185 35300e20d6125e3b864e3e681148815f 225 SUPERFAMILY SSF56784 12 212 8.68E-42 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS08185 35300e20d6125e3b864e3e681148815f 225 TIGRFAM TIGR01509 HAD-SF-IA-v3: HAD hydrolase, family IA, variant 3 127 192 1.2E-10 T 17-03-2017 IPR006439 HAD hydrolase, subfamily IA GO:0008152|GO:0016787 SHXM_RS08185 35300e20d6125e3b864e3e681148815f 225 Gene3D G3DSA:3.40.50.1000 75 213 2.9E-29 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS16980 ba7d078b5f53aa85d64e6e36fa602f02 239 Pfam PF06386 Gas vesicle synthesis protein GvpL/GvpF 3 237 5.8E-62 T 17-03-2017 IPR009430 Gas vesicle protein GvpL/GvpF GO:0031411|GO:0031412 SHXM_RS04840 5cde4201e89b56dc36f36636b565ea4a 841 Pfam PF02687 FtsX-like permease family 267 385 1.0E-18 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS04840 5cde4201e89b56dc36f36636b565ea4a 841 Pfam PF02687 FtsX-like permease family 720 830 1.6E-15 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS04840 5cde4201e89b56dc36f36636b565ea4a 841 Pfam PF12704 MacB-like periplasmic core domain 20 234 8.7E-16 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS31010 a5865ac555167f53f656217e69a449ab 289 Pfam PF06724 Domain of Unknown Function (DUF1206) 219 287 4.5E-16 T 17-03-2017 IPR009597 Domain of unknown function DUF1206 SHXM_RS31010 a5865ac555167f53f656217e69a449ab 289 Pfam PF06724 Domain of Unknown Function (DUF1206) 125 193 1.9E-16 T 17-03-2017 IPR009597 Domain of unknown function DUF1206 SHXM_RS31010 a5865ac555167f53f656217e69a449ab 289 Pfam PF06724 Domain of Unknown Function (DUF1206) 41 108 1.7E-22 T 17-03-2017 IPR009597 Domain of unknown function DUF1206 SHXM_RS19515 4e8cd07769288ffc7612f82ebb275dc7 300 SUPERFAMILY SSF51695 59 287 8.11E-42 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS19515 4e8cd07769288ffc7612f82ebb275dc7 300 Gene3D G3DSA:3.20.20.190 51 287 3.7E-43 T 17-03-2017 IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain GO:0006629|GO:0008081 SHXM_RS19515 4e8cd07769288ffc7612f82ebb275dc7 300 Pfam PF03009 Glycerophosphoryl diester phosphodiesterase family 63 284 1.2E-19 T 17-03-2017 IPR030395 Glycerophosphodiester phosphodiesterase domain GO:0006629|GO:0008081 SHXM_RS37885 67dc63b0d1438b4e0bcf8593da8f8cd6 184 Pfam PF13160 Protein of unknown function (DUF3995) 28 117 2.2E-10 T 17-03-2017 IPR025058 Protein of unknown function DUF3995 SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 SUPERFAMILY SSF53474 346 502 5.3E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 SUPERFAMILY SSF53474 213 267 5.3E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 SUPERFAMILY SSF53474 114 172 5.3E-26 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 Gene3D G3DSA:3.40.50.1820 211 337 4.1E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 Gene3D G3DSA:3.40.50.1820 384 506 4.1E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 Gene3D G3DSA:3.40.50.1820 83 171 4.1E-57 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS47255 9431e5703fa512b47f39cec9d025ecd0 520 Pfam PF00561 alpha/beta hydrolase fold 119 490 2.3E-25 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS32260 5eddf3d9d26ed9bccba34b8b1b6ef8b6 595 Pfam PF06276 Ferric iron reductase FhuF-like transporter 412 569 1.0E-40 T 17-03-2017 IPR022770 Ferric iron reductase FhuF domain SHXM_RS32260 5eddf3d9d26ed9bccba34b8b1b6ef8b6 595 Pfam PF04183 IucA / IucC family 141 390 1.2E-77 T 17-03-2017 IPR007310 Aerobactin siderophore biosynthesis, IucA/IucC, N-terminal GO:0015343|GO:0019290 SHXM_RS13420 3b683697e1b568a8b3155892b8c6def2 263 Pfam PF01066 CDP-alcohol phosphatidyltransferase 53 118 1.9E-9 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS18720 28cb45bbc3863f57d1ed821813ab990f 169 Pfam PF14342 Domain of unknown function (DUF4396) 28 160 4.0E-42 T 17-03-2017 IPR025509 Domain of unknown function DUF4396 SHXM_RS50565 29bd18f70498d8ca88a1232b57860d03 67 SUPERFAMILY SSF53335 8 65 4.08E-5 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS50565 29bd18f70498d8ca88a1232b57860d03 67 Gene3D G3DSA:3.40.50.150 12 64 5.8E-4 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS12675 19fc66620938e0aec9d1e8c0b5dc0697 137 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 120 3.5E-38 T 17-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 SHXM_RS27240 3637786548002c1d62d104a7f293e991 374 Pfam PF07228 Stage II sporulation protein E (SpoIIE) 171 355 1.9E-38 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS27240 3637786548002c1d62d104a7f293e991 374 SMART SM00331 143 356 7.2E-35 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS27240 3637786548002c1d62d104a7f293e991 374 SUPERFAMILY SSF81606 158 353 3.66E-6 T 17-03-2017 IPR001932 PPM-type phosphatase domain GO:0003824 KEGG: 04660+3.1.3.16 SHXM_RS09020 069fb3f067c6177df839b0a8bf9a776c 400 SUPERFAMILY SSF53098 122 353 2.96E-25 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS09020 069fb3f067c6177df839b0a8bf9a776c 400 Pfam PF01609 Transposase DDE domain 128 345 1.1E-14 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS09020 069fb3f067c6177df839b0a8bf9a776c 400 Pfam PF13006 Insertion element 4 transposase N-terminal 16 108 1.1E-33 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS39055 d47ab6ddc5ca323f58e10877a9a1bedf 142 SUPERFAMILY SSF53933 48 139 1.76E-37 T 17-03-2017 IPR016191 Ribonuclease/ribotoxin GO:0003723|GO:0004540 SHXM_RS39055 d47ab6ddc5ca323f58e10877a9a1bedf 142 Pfam PF00545 ribonuclease 57 135 2.1E-28 T 17-03-2017 IPR000026 Guanine-specific ribonuclease N1/T1/U2 GO:0003723|GO:0004521 SHXM_RS39055 d47ab6ddc5ca323f58e10877a9a1bedf 142 Gene3D G3DSA:3.10.450.30 49 139 4.0E-41 T 17-03-2017 IPR016191 Ribonuclease/ribotoxin GO:0003723|GO:0004540 SHXM_RS06900 f1156d43f35cf5fdd38a067309c5f124 286 Gene3D G3DSA:1.10.3720.10 13 274 4.4E-66 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06900 f1156d43f35cf5fdd38a067309c5f124 286 SUPERFAMILY SSF161098 12 286 5.79E-70 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS06900 f1156d43f35cf5fdd38a067309c5f124 286 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 91 280 8.9E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS27190 98dd3b839347b375fbf338095442f967 349 SUPERFAMILY SSF51126 31 313 1.6E-16 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS27190 98dd3b839347b375fbf338095442f967 349 Gene3D G3DSA:2.160.20.10 24 316 2.4E-26 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS33885 bfbc4ed2ed68f24f5ae76ba645588e71 66 Pfam PF04149 Domain of unknown function (DUF397) 5 57 2.3E-13 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS04520 863ed4764cc245c154f9456c6c73feaa 337 Pfam PF03773 Predicted permease 58 333 2.5E-44 T 17-03-2017 IPR005524 Predicted permease DUF318 SHXM_RS40295 e87f19426b5cd867cf1530010093a842 199 Pfam PF03752 Short repeats of unknown function 155 196 4.0E-9 T 17-03-2017 IPR005506 Protein of unknown function DUF312 SHXM_RS40295 e87f19426b5cd867cf1530010093a842 199 Pfam PF03752 Short repeats of unknown function 55 95 9.0E-10 T 17-03-2017 IPR005506 Protein of unknown function DUF312 SHXM_RS44180 799397770317c85dd8651e2056366af3 206 Pfam PF01810 LysE type translocator 15 201 3.4E-24 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS19500 250051305821b518b9b4c0009b22fb7d 325 Pfam PF03239 Iron permease FTR1 family 1 253 3.0E-66 T 17-03-2017 IPR004923 Iron permease FTR1/Fip1/EfeU GO:0005381|GO:0006827|GO:0016020|GO:0033573 SHXM_RS18985 2910f43db94e2995f17f10c332803e98 427 Pfam PF03824 High-affinity nickel-transport protein 176 312 6.4E-7 T 17-03-2017 IPR011541 Nickel/cobalt transporter, high-affinity GO:0015099|GO:0016021|GO:0035444|GO:0046872 SHXM_RS18985 2910f43db94e2995f17f10c332803e98 427 PRINTS PR01955 Frankia sp. LanC-like protein signature 345 362 5.5E-5 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS18985 2910f43db94e2995f17f10c332803e98 427 PRINTS PR01955 Frankia sp. LanC-like protein signature 9 24 5.5E-5 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS18985 2910f43db94e2995f17f10c332803e98 427 PRINTS PR01955 Frankia sp. LanC-like protein signature 159 183 5.5E-5 T 17-03-2017 IPR020434 LanC-like protein SHXM_RS22645 f554161a9530806fd8f69b8d1cda7c4a 173 Pfam PF00582 Universal stress protein family 40 173 1.5E-22 T 17-03-2017 IPR006016 UspA GO:0006950 SHXM_RS22645 f554161a9530806fd8f69b8d1cda7c4a 173 PRINTS PR01438 Universal stress protein signature 37 55 1.9E-6 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS22645 f554161a9530806fd8f69b8d1cda7c4a 173 PRINTS PR01438 Universal stress protein signature 151 173 1.9E-6 T 17-03-2017 IPR006015 Universal stress protein A SHXM_RS22645 f554161a9530806fd8f69b8d1cda7c4a 173 Gene3D G3DSA:3.40.50.620 39 173 9.4E-33 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS22645 f554161a9530806fd8f69b8d1cda7c4a 173 SUPERFAMILY SSF52402 40 173 2.18E-21 T 17-03-2017 SHXM_RS21255 e8f8dce4c706dae482e94dad8f56fa84 334 SUPERFAMILY SSF52540 122 301 1.36E-40 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21255 e8f8dce4c706dae482e94dad8f56fa84 334 Gene3D G3DSA:3.40.50.300 122 325 4.5E-102 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS21255 e8f8dce4c706dae482e94dad8f56fa84 334 Pfam PF02562 PhoH-like protein 123 326 7.5E-95 T 17-03-2017 IPR003714 PhoH-like protein GO:0005524 SHXM_RS23395 c49293c00efc6bedf4e3cfc671054f42 410 Pfam PF02378 Phosphotransferase system, EIIC 27 328 1.8E-71 T 17-03-2017 IPR003352 Phosphotransferase system, EIIC GO:0008982|GO:0009401|GO:0016020 SHXM_RS23860 b20622fb206770020c77be7a76e50e6d 225 Pfam PF04886 PT repeat 66 100 6.3E-8 T 17-03-2017 IPR006970 PT repeat SHXM_RS23860 b20622fb206770020c77be7a76e50e6d 225 Pfam PF04886 PT repeat 105 139 1.8E-6 T 17-03-2017 IPR006970 PT repeat SHXM_RS23860 b20622fb206770020c77be7a76e50e6d 225 Pfam PF04886 PT repeat 93 128 4.1E-7 T 17-03-2017 IPR006970 PT repeat SHXM_RS28960 b95c1414ca7f269ed69c6a937d669e07 191 SUPERFAMILY SSF160904 7 181 8.24E-40 T 17-03-2017 SHXM_RS28960 b95c1414ca7f269ed69c6a937d669e07 191 Pfam PF07336 Putative stress-induced transcription regulator 14 135 2.0E-19 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS28960 b95c1414ca7f269ed69c6a937d669e07 191 Gene3D G3DSA:1.10.3300.10 8 184 1.7E-40 T 17-03-2017 IPR023286 ABATE domain SHXM_RS28960 b95c1414ca7f269ed69c6a937d669e07 191 Pfam PF11706 CGNR zinc finger 141 181 3.8E-15 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS20220 d373b58ff736bc7e883a5550db98c10b 191 Gene3D G3DSA:2.60.60.30 18 185 4.0E-74 T 17-03-2017 SHXM_RS20220 d373b58ff736bc7e883a5550db98c10b 191 Pfam PF02342 TerD domain 3 187 1.6E-84 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS20775 d8b708e63e98827ba078b22c954bc4d6 400 Pfam PF02371 Transposase IS116/IS110/IS902 family 275 357 1.3E-22 T 17-03-2017 IPR003346 Transposase, IS116/IS110/IS902 GO:0003677|GO:0004803|GO:0006313 SHXM_RS20775 d8b708e63e98827ba078b22c954bc4d6 400 Pfam PF01548 Transposase 11 166 6.5E-44 T 17-03-2017 IPR002525 Transposase, IS111A/IS1328/IS1533, N-terminal GO:0003677|GO:0004803|GO:0006313 SHXM_RS32320 05138c834cd2a5d1d0a2ce59611318e4 225 SUPERFAMILY SSF48498 101 207 1.08E-28 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS32320 05138c834cd2a5d1d0a2ce59611318e4 225 Gene3D G3DSA:1.10.357.10 23 213 2.1E-39 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS32320 05138c834cd2a5d1d0a2ce59611318e4 225 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 35 48 2.0E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32320 05138c834cd2a5d1d0a2ce59611318e4 225 PRINTS PR00455 TetR bacterial regulatory protein HTH signature 55 78 2.0E-8 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32320 05138c834cd2a5d1d0a2ce59611318e4 225 Pfam PF00440 Bacterial regulatory proteins, tetR family 35 79 6.2E-11 T 17-03-2017 IPR001647 DNA-binding HTH domain, TetR-type GO:0003677 SHXM_RS32320 05138c834cd2a5d1d0a2ce59611318e4 225 SUPERFAMILY SSF46689 23 104 3.44E-15 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS45225 c968e1b64bf8a3f9e1027d2275d0d43e 151 TIGRFAM TIGR02241 TIGR02241: conserved hypothetical phage tail region protein 15 150 1.7E-32 T 17-03-2017 IPR011747 Conserved hypothetical protein CHP02241 SHXM_RS45225 c968e1b64bf8a3f9e1027d2275d0d43e 151 Pfam PF06841 T4-like virus tail tube protein gp19 18 148 8.5E-37 T 17-03-2017 IPR010667 Bacteriophage T4, Gp19, tail tube GO:0005198 SHXM_RS26515 36f16ca6586bb0ec840216f08b933774 209 Gene3D G3DSA:1.10.10.10 4 102 1.3E-16 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS26515 36f16ca6586bb0ec840216f08b933774 209 Pfam PF03551 Transcriptional regulator PadR-like family 8 83 3.9E-10 T 17-03-2017 IPR005149 Transcription regulator PadR, N-terminal SHXM_RS26515 36f16ca6586bb0ec840216f08b933774 209 SUPERFAMILY SSF46785 4 179 5.72E-25 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS38045 9d691dcc2c1c78ab479fd8ef22ddc8d2 429 Gene3D G3DSA:3.40.190.10 157 361 1.8E-31 T 17-03-2017 SHXM_RS38045 9d691dcc2c1c78ab479fd8ef22ddc8d2 429 SUPERFAMILY SSF53850 34 427 2.64E-55 T 17-03-2017 SHXM_RS38045 9d691dcc2c1c78ab479fd8ef22ddc8d2 429 Pfam PF01547 Bacterial extracellular solute-binding protein 56 344 8.6E-29 T 17-03-2017 IPR006059 Solute-binding family 1 GO:0005215|GO:0006810 SHXM_RS40690 735e48138bd031c4be4bfe966542c76f 446 SUPERFAMILY SSF103473 15 421 1.57E-61 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS40690 735e48138bd031c4be4bfe966542c76f 446 Pfam PF00083 Sugar (and other) transporter 18 409 2.2E-24 T 17-03-2017 IPR005828 Major facilitator, sugar transporter-like GO:0016021|GO:0022857|GO:0055085 SHXM_RS40690 735e48138bd031c4be4bfe966542c76f 446 Gene3D G3DSA:1.20.1250.20 16 224 1.3E-22 T 17-03-2017 SHXM_RS40690 735e48138bd031c4be4bfe966542c76f 446 Gene3D G3DSA:1.20.1250.20 244 418 1.0E-17 T 17-03-2017 SHXM_RS47745 f5d53d973bfe9949cacce6ddd7e8da88 76 SUPERFAMILY SSF56801 3 66 1.7E-5 T 17-03-2017 SHXM_RS17240 79a50c0b15073c7ac342b5d01f4ef8df 267 ProDom PD040491 SCO1799 RV1486C/MT1533 MB1522C CGL1536 ML1804 MAV321 10 252 2.0E-71 T 17-03-2017 SHXM_RS27195 cc91a63bf5fa750037b00b1eb90cd342 114 Gene3D G3DSA:3.40.50.720 6 113 5.8E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS27195 cc91a63bf5fa750037b00b1eb90cd342 114 SUPERFAMILY SSF51735 10 110 2.82E-17 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS04415 380dd6590cbc2b1deb6210dfb7207693 135 SUPERFAMILY SSF54427 3 124 1.41E-20 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS04415 380dd6590cbc2b1deb6210dfb7207693 135 Gene3D G3DSA:3.10.450.50 3 127 1.5E-21 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS04415 380dd6590cbc2b1deb6210dfb7207693 135 Pfam PF13474 SnoaL-like domain 5 126 1.1E-18 T 17-03-2017 IPR009959 Polyketide cyclase SnoaL-like domain SHXM_RS17760 e1708c005b82febb813ecb0ee233d994 405 Pfam PF02342 TerD domain 223 391 6.1E-40 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS17760 e1708c005b82febb813ecb0ee233d994 405 Pfam PF02342 TerD domain 20 158 1.3E-28 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS17760 e1708c005b82febb813ecb0ee233d994 405 Gene3D G3DSA:2.60.60.30 241 394 3.0E-48 T 17-03-2017 SHXM_RS17760 e1708c005b82febb813ecb0ee233d994 405 Gene3D G3DSA:2.60.60.30 20 156 3.0E-27 T 17-03-2017 SHXM_RS34445 516e5d6262fb6ecd654accd0fb042f28 237 Pfam PF13398 Peptidase M50B-like 28 229 2.9E-60 T 17-03-2017 SHXM_RS11620 740ef4e02518acb21c5cf5c6ec6cf23e 223 SMART SM00860 45 169 0.0061 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS11620 740ef4e02518acb21c5cf5c6ec6cf23e 223 SUPERFAMILY SSF160631 24 170 7.72E-8 T 17-03-2017 SHXM_RS11620 740ef4e02518acb21c5cf5c6ec6cf23e 223 Pfam PF09346 SMI1 / KNR4 family (SUKH-1) 45 140 9.5E-6 T 17-03-2017 IPR018958 SMI1/KNR4-like domain SHXM_RS08565 a63753ebc7c2649c6fa1fa18ddda9c9c 141 Pfam PF00583 Acetyltransferase (GNAT) family 51 127 1.5E-12 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS08565 a63753ebc7c2649c6fa1fa18ddda9c9c 141 SUPERFAMILY SSF55729 3 133 3.82E-27 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS08565 a63753ebc7c2649c6fa1fa18ddda9c9c 141 Gene3D G3DSA:3.40.630.30 4 133 1.7E-28 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS23580 ba99af8941dac3edf2af18fd4b5419c6 127 Pfam PF02661 Fic/DOC family 4 83 2.3E-9 T 17-03-2017 IPR003812 Fido domain SHXM_RS23580 ba99af8941dac3edf2af18fd4b5419c6 127 TIGRFAM TIGR01550 DOC_P1: death-on-curing family protein 34 121 7.7E-13 T 17-03-2017 IPR006440 Death on curing protein GO:0016301 SHXM_RS27730 e8d177ac389615416c75ebdec4acfffe 242 Pfam PF12679 ABC-2 family transporter protein 46 172 1.8E-11 T 17-03-2017 IPR032688 ABC-2 family transporter protein GO:0006810 SHXM_RS25255 c7804b2614e43c2ae8d4b9eabc347729 129 Pfam PF11222 Protein of unknown function (DUF3017) 37 107 1.9E-22 T 17-03-2017 IPR021385 Protein of unknown function DUF3017 SHXM_RS08820 996f83a775150e47dc3063929f3919cf 81 Pfam PF13006 Insertion element 4 transposase N-terminal 17 76 5.4E-21 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS29570 9eb51cbcb602b1406a055eb11aac95d6 142 Gene3D G3DSA:3.30.565.10 40 132 1.0E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29570 9eb51cbcb602b1406a055eb11aac95d6 142 Pfam PF13581 Histidine kinase-like ATPase domain 22 129 1.5E-13 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS29570 9eb51cbcb602b1406a055eb11aac95d6 142 SUPERFAMILY SSF55874 31 128 1.22E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS40260 0a8ba3b7031296eae7ee8237a2a36569 214 SUPERFAMILY SSF52499 3 177 4.97E-38 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS40260 0a8ba3b7031296eae7ee8237a2a36569 214 Gene3D G3DSA:3.40.50.850 3 202 3.1E-35 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS40260 0a8ba3b7031296eae7ee8237a2a36569 214 Pfam PF00857 Isochorismatase family 11 163 2.7E-25 T 17-03-2017 IPR000868 Isochorismatase-like GO:0003824|GO:0008152 SHXM_RS34160 1d59eba553d577feca65e4e8a252be28 201 Pfam PF05076 Suppressor of fused protein (SUFU) 29 194 1.4E-34 T 17-03-2017 IPR020941 Suppressor of fused-like domain Reactome: R-HSA-5610780|Reactome: R-HSA-5610783|Reactome: R-HSA-5610785|Reactome: R-HSA-5610787|Reactome: R-HSA-5632684 SHXM_RS50175 fbbb86f76f003d74c21a97a888a296da 529 Pfam PF07905 Purine catabolism regulatory protein-like family 14 130 1.9E-25 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS50175 fbbb86f76f003d74c21a97a888a296da 529 Pfam PF13556 PucR C-terminal helix-turn-helix domain 462 519 2.9E-21 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS22970 282a8a3b0955edaab5e7c700be3efeb1 315 Gene3D G3DSA:3.40.50.720 108 275 1.4E-47 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22970 282a8a3b0955edaab5e7c700be3efeb1 315 Pfam PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 107 274 1.5E-42 T 17-03-2017 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain GO:0051287|GO:0055114 SHXM_RS22970 282a8a3b0955edaab5e7c700be3efeb1 315 Gene3D G3DSA:3.40.50.720 5 107 1.4E-5 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22970 282a8a3b0955edaab5e7c700be3efeb1 315 SUPERFAMILY SSF52283 5 132 2.1E-7 T 17-03-2017 SHXM_RS22970 282a8a3b0955edaab5e7c700be3efeb1 315 SUPERFAMILY SSF51735 100 275 3.55E-43 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS22970 282a8a3b0955edaab5e7c700be3efeb1 315 ProSitePatterns PS00671 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. 213 229 - T 17-03-2017 IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site SHXM_RS02035 98c5d42cdb2905b7b010828b4ece585e 207 Gene3D G3DSA:3.30.460.10 4 60 1.8E-5 T 17-03-2017 SHXM_RS02035 98c5d42cdb2905b7b010828b4ece585e 207 SUPERFAMILY SSF81301 9 75 5.82E-6 T 17-03-2017 SHXM_RS07725 1e5bb619cd8e38f92615b9e8b6a0ff41 252 Pfam PF01904 Protein of unknown function DUF72 20 237 7.5E-56 T 17-03-2017 IPR002763 Protein of unknown function DUF72 SHXM_RS07725 1e5bb619cd8e38f92615b9e8b6a0ff41 252 Gene3D G3DSA:3.20.20.410 1 239 6.6E-74 T 17-03-2017 IPR002763 Protein of unknown function DUF72 SHXM_RS07725 1e5bb619cd8e38f92615b9e8b6a0ff41 252 SUPERFAMILY SSF117396 1 239 2.22E-73 T 17-03-2017 IPR002763 Protein of unknown function DUF72 SHXM_RS10425 1d6e7fbe0d4a4ac91f55bc0c6b0a2f3d 297 Pfam PF09678 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) 39 265 7.0E-61 T 17-03-2017 IPR019108 Cytochrome c oxidase caa3-type, assembly factor CtaG-related SHXM_RS01535 83e158f975eeb7057cc1efa571950278 176 Gene3D G3DSA:2.60.40.920 50 112 2.9E-4 T 17-03-2017 IPR003344 Big-1 (bacterial Ig-like domain 1) domain SHXM_RS33585 6ada7352ad8de4ce5d5f6f37c0658f02 542 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 359 426 3.0E-8 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS26180 7f968fb55d0a8565e214ed6519792ec8 341 Pfam PF00248 Aldo/keto reductase family 18 315 4.2E-74 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS26180 7f968fb55d0a8565e214ed6519792ec8 341 SUPERFAMILY SSF51430 1 316 7.99E-96 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS26180 7f968fb55d0a8565e214ed6519792ec8 341 Gene3D G3DSA:3.20.20.100 9 316 3.3E-92 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS26180 7f968fb55d0a8565e214ed6519792ec8 341 PRINTS PR00069 Aldo-keto reductase signature 105 123 1.5E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS26180 7f968fb55d0a8565e214ed6519792ec8 341 PRINTS PR00069 Aldo-keto reductase signature 41 65 1.5E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS26180 7f968fb55d0a8565e214ed6519792ec8 341 PRINTS PR00069 Aldo-keto reductase signature 136 153 1.5E-9 T 17-03-2017 IPR020471 Aldo/keto reductase GO:0016491|GO:0055114 SHXM_RS01110 df5bcfe9f24268cd38139b21a27969be 154 Pfam PF13592 Winged helix-turn helix 39 97 1.6E-22 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS37620 d8601ca046a1a4691e7fe6562562f178 148 Pfam PF11292 Protein of unknown function (DUF3093) 4 142 1.6E-45 T 17-03-2017 IPR021443 Protein of unknown function DUF3093 SHXM_RS12255 6893a43f2cdb12fea8ffe5f3f671a101 253 Pfam PF10935 Protein of unknown function (DUF2637) 122 231 6.6E-9 T 17-03-2017 IPR021235 Protein of unknown function DUF2637 SHXM_RS06100 f70486a1e16b8f70c0b8329e6b4d4925 479 ProSitePatterns PS00218 Amino acid permeases signature. 62 92 - T 17-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SHXM_RS06100 f70486a1e16b8f70c0b8329e6b4d4925 479 Pfam PF00324 Amino acid permease 37 443 2.9E-103 T 17-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 SHXM_RS06100 f70486a1e16b8f70c0b8329e6b4d4925 479 PIRSF PIRSF006060 7 477 1.0E-60 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS44400 a9937501164ae9d154eb1eca06921bfc 262 SMART SM00479 6 194 1.0E-8 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS44400 a9937501164ae9d154eb1eca06921bfc 262 SUPERFAMILY SSF53098 2 191 2.03E-35 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS44400 a9937501164ae9d154eb1eca06921bfc 262 Gene3D G3DSA:3.30.420.10 2 188 3.1E-32 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS44400 a9937501164ae9d154eb1eca06921bfc 262 Pfam PF00929 Exonuclease 9 184 4.2E-15 T 17-03-2017 IPR013520 Exonuclease, RNase T/DNA polymerase III SHXM_RS21370 f6c439312f6e9e62ecb64f3faa65949a 285 Pfam PF13349 Putative adhesin 63 281 2.0E-10 T 17-03-2017 IPR025164 Putative adhesin SHXM_RS21645 2faeb73251a12e272d036a5b6c6f56dc 314 PIRSF PIRSF038471 2 282 1.3E-39 T 17-03-2017 IPR007221 Rod shape-determining protein MreC GO:0008360 SHXM_RS21645 2faeb73251a12e272d036a5b6c6f56dc 314 Pfam PF04085 rod shape-determining protein MreC 131 270 2.4E-33 T 17-03-2017 IPR007221 Rod shape-determining protein MreC GO:0008360 SHXM_RS41240 bb964c04d5b51d5edfabe745eb7658ab 715 SUPERFAMILY SSF48371 225 263 5.76E-8 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS41240 bb964c04d5b51d5edfabe745eb7658ab 715 SUPERFAMILY SSF48371 72 186 5.76E-8 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS41240 bb964c04d5b51d5edfabe745eb7658ab 715 SUPERFAMILY SSF48371 307 420 5.76E-8 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS41240 bb964c04d5b51d5edfabe745eb7658ab 715 Gene3D G3DSA:1.25.10.10 255 426 2.2E-4 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS41240 bb964c04d5b51d5edfabe745eb7658ab 715 Gene3D G3DSA:1.25.10.10 13 254 7.2E-4 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS27200 6d9c06ffcfa20d1487560d8a2a2bba0a 330 Gene3D G3DSA:2.120.10.30 229 292 0.001 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS27200 6d9c06ffcfa20d1487560d8a2a2bba0a 330 Gene3D G3DSA:2.120.10.30 18 228 4.3E-14 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS27200 6d9c06ffcfa20d1487560d8a2a2bba0a 330 SUPERFAMILY SSF63829 59 310 3.6E-24 T 17-03-2017 SHXM_RS35140 101fd8cce1e6efb12ddbd67f2cf4245d 417 Pfam PF00589 Phage integrase family 198 381 8.7E-8 T 17-03-2017 IPR002104 Integrase, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS35140 101fd8cce1e6efb12ddbd67f2cf4245d 417 Gene3D G3DSA:1.10.443.10 198 395 6.8E-21 T 17-03-2017 IPR013762 Integrase-like, catalytic domain GO:0003677|GO:0006310|GO:0015074 SHXM_RS35140 101fd8cce1e6efb12ddbd67f2cf4245d 417 SUPERFAMILY SSF56349 135 393 1.47E-26 T 17-03-2017 IPR011010 DNA breaking-rejoining enzyme, catalytic core GO:0003677 SHXM_RS11145 dc047bbd11e7ac9ac9e1501d91ba3b87 242 SUPERFAMILY SSF46689 14 80 1.23E-8 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS11145 dc047bbd11e7ac9ac9e1501d91ba3b87 242 SUPERFAMILY SSF48498 94 227 4.0E-22 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS11145 dc047bbd11e7ac9ac9e1501d91ba3b87 242 Gene3D G3DSA:1.10.357.10 15 224 6.5E-29 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS12680 aa8e11d21ff444b9e34d157773b3b333 189 Pfam PF11706 CGNR zinc finger 141 184 3.9E-18 T 17-03-2017 IPR021005 Zinc finger, CGNR SHXM_RS12680 aa8e11d21ff444b9e34d157773b3b333 189 SUPERFAMILY SSF160904 2 183 1.44E-49 T 17-03-2017 SHXM_RS12680 aa8e11d21ff444b9e34d157773b3b333 189 Gene3D G3DSA:1.10.3300.10 3 186 1.6E-53 T 17-03-2017 IPR023286 ABATE domain SHXM_RS12680 aa8e11d21ff444b9e34d157773b3b333 189 Pfam PF07336 Putative stress-induced transcription regulator 12 135 1.1E-16 T 17-03-2017 IPR010852 Putative stress-induced transcription regulator SHXM_RS08920 f7143bb123fff8343396670dfbe825ea 111 Pfam PF11774 Lsr2 1 110 3.4E-32 T 17-03-2017 IPR024412 Lsr2 SHXM_RS08920 f7143bb123fff8343396670dfbe825ea 111 ProDom PD026347 LSR2-LIKE LSR2 ANTIGEN IMMUNE PRECURSOR RESPONSE SIGNAL PLASMID LYSYL GP61 1 110 4.0E-25 T 17-03-2017 IPR024412 Lsr2 SHXM_RS40520 c7106213527796aba9f2958dd0b1ae8b 452 SUPERFAMILY SSF103473 6 429 1.1E-60 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS40520 c7106213527796aba9f2958dd0b1ae8b 452 Pfam PF07690 Major Facilitator Superfamily 24 358 4.1E-28 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS40520 c7106213527796aba9f2958dd0b1ae8b 452 Gene3D G3DSA:1.20.1250.20 247 432 2.2E-14 T 17-03-2017 SHXM_RS40520 c7106213527796aba9f2958dd0b1ae8b 452 Gene3D G3DSA:1.20.1250.20 20 222 1.8E-21 T 17-03-2017 SHXM_RS20655 0ada8b04cadb14bfb55c87d16b8d3e00 258 TIGRFAM TIGR04222 near_uncomplex: TIGR04222 domain 50 157 6.1E-18 T 17-03-2017 IPR026467 Ser/Gly rich, Cys interspersed, C-terminal domain SHXM_RS33340 8d06be97727aa3930c330957277f6087 427 Gene3D G3DSA:1.10.260.40 8 78 2.3E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS06590 6d1b42edb6ecb956e376dddadfcd7b06 404 Pfam PF13224 Domain of unknown function (DUF4032) 231 398 1.7E-64 T 17-03-2017 IPR025111 Domain of unknown function DUF4032 SHXM_RS06590 6d1b42edb6ecb956e376dddadfcd7b06 404 Pfam PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family 60 180 2.0E-7 T 17-03-2017 IPR010440 Lipopolysaccharide kinase GO:0005524|GO:0016020|GO:0016773 Reactome: R-HSA-6782315|Reactome: R-HSA-6804756 SHXM_RS06590 6d1b42edb6ecb956e376dddadfcd7b06 404 SUPERFAMILY SSF56112 35 166 2.04E-6 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS05845 f05070add7e417edbf5fab81bb6c7c6a 305 Pfam PF14065 Protein of unknown function (DUF4255) 9 192 4.2E-43 T 17-03-2017 IPR025351 Protein of unknown function DUF4255 SHXM_RS07505 56ba48f55124224307dea1f57df0b53d 381 Pfam PF07470 Glycosyl Hydrolase Family 88 34 375 1.4E-76 T 17-03-2017 IPR010905 Glycosyl hydrolase, family 88 SHXM_RS07505 56ba48f55124224307dea1f57df0b53d 381 SUPERFAMILY SSF48208 46 379 3.4E-60 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS07505 56ba48f55124224307dea1f57df0b53d 381 Gene3D G3DSA:1.50.10.10 27 375 2.6E-95 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS29550 78de3ebbf19d17e4585d169af31ae1d1 435 Pfam PF12307 Protein of unknown function (DUF3631) 227 414 4.0E-68 T 17-03-2017 IPR022081 Domain of unknown function DUF3631 SHXM_RS05310 70531719632a8df4e84d0a07f7bdd110 317 SMART SM00826 46 208 6.8E-79 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS05310 70531719632a8df4e84d0a07f7bdd110 317 Pfam PF14765 Polyketide synthase dehydratase 46 316 3.2E-58 T 17-03-2017 IPR020807 Polyketide synthase, dehydratase domain Reactome: R-HSA-163765|Reactome: R-HSA-199220|Reactome: R-HSA-2426168|Reactome: R-HSA-75105 SHXM_RS47715 2ae4fc6557af03c0131de8a3b57144f6 83 SUPERFAMILY SSF55874 5 72 2.58E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14290 eabb01b673f3370d7c450a2dba21e9d5 246 Pfam PF13649 Methyltransferase domain 54 144 3.6E-19 T 17-03-2017 SHXM_RS14290 eabb01b673f3370d7c450a2dba21e9d5 246 SUPERFAMILY SSF53335 10 214 4.8E-35 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS14290 eabb01b673f3370d7c450a2dba21e9d5 246 Gene3D G3DSA:3.40.50.150 9 191 1.0E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS26345 98acecb43ca143c2e922bb50790a5520 379 Gene3D G3DSA:3.40.640.10 28 247 7.7E-31 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS26345 98acecb43ca143c2e922bb50790a5520 379 SUPERFAMILY SSF53383 27 310 4.48E-55 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS26345 98acecb43ca143c2e922bb50790a5520 379 Pfam PF01212 Beta-eliminating lyase 51 280 4.1E-23 T 17-03-2017 IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase GO:0006520|GO:0016829 Reactome: R-HSA-6783984 SHXM_RS46030 a800263350c14863724716ffc0e0066f 187 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 16 76 2.3E-8 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS28100 6c7faeac7ab6c8116966ed562a5dbe8d 379 TIGRFAM TIGR03592 yidC_oxa1_cterm: membrane protein insertase, YidC/Oxa1 family 35 252 2.3E-61 T 17-03-2017 IPR028055 Membrane insertase YidC/Oxa1, C-terminal SHXM_RS28100 6c7faeac7ab6c8116966ed562a5dbe8d 379 Pfam PF02096 60Kd inner membrane protein 35 252 1.1E-58 T 17-03-2017 IPR001708 Membrane insertase OXA1/ALB3/YidC GO:0016021|GO:0051205 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 PIRSF PIRSF000429 1 342 5.1E-14 T 17-03-2017 IPR002155 Thiolase GO:0008152|GO:0016747 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 Gene3D G3DSA:3.40.47.10 154 182 3.0E-9 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 Gene3D G3DSA:3.40.47.10 238 340 3.0E-9 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 Gene3D G3DSA:3.40.47.10 14 110 8.9E-6 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 Gene3D G3DSA:3.40.47.10 203 223 8.9E-6 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 Gene3D G3DSA:3.40.47.10 151 152 8.9E-6 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 SUPERFAMILY SSF53901 180 339 7.35E-18 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS43605 9ba4c28b2ec2191a86d1f5a1449c51d6 358 SUPERFAMILY SSF53901 4 117 7.35E-18 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS24520 03c12906c18c37eb6161ee4c649ab1af 846 Pfam PF12704 MacB-like periplasmic core domain 491 682 2.9E-13 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS24520 03c12906c18c37eb6161ee4c649ab1af 846 Pfam PF12704 MacB-like periplasmic core domain 17 236 1.1E-15 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS24520 03c12906c18c37eb6161ee4c649ab1af 846 Pfam PF02687 FtsX-like permease family 723 838 4.2E-21 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS24520 03c12906c18c37eb6161ee4c649ab1af 846 Pfam PF02687 FtsX-like permease family 271 392 1.8E-24 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS37755 30998bc757368aa063e03fcbda76a892 317 Pfam PF00109 Beta-ketoacyl synthase, N-terminal domain 29 173 2.6E-14 T 17-03-2017 IPR014030 Beta-ketoacyl synthase, N-terminal SHXM_RS37755 30998bc757368aa063e03fcbda76a892 317 Gene3D G3DSA:3.40.47.10 2 199 5.9E-20 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS37755 30998bc757368aa063e03fcbda76a892 317 SUPERFAMILY SSF53901 3 209 2.31E-23 T 17-03-2017 IPR016039 Thiolase-like GO:0003824|GO:0008152 SHXM_RS28915 c441efcd2c9898687330bda49adb4abf 180 Pfam PF08044 Domain of unknown function (DUF1707) 11 62 8.4E-18 T 17-03-2017 IPR012551 Protein of unknown function DUF1707 SHXM_RS14410 25a6a8837b48ec904016ca841996086c 137 Gene3D G3DSA:3.30.565.10 23 132 4.1E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14410 25a6a8837b48ec904016ca841996086c 137 Pfam PF13581 Histidine kinase-like ATPase domain 22 133 5.0E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14410 25a6a8837b48ec904016ca841996086c 137 SUPERFAMILY SSF55874 41 133 9.03E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14170 98761b2e97df1967124aa78b99c989e7 599 Pfam PF01040 UbiA prenyltransferase family 34 183 2.0E-19 T 17-03-2017 IPR000537 UbiA prenyltransferase family GO:0004659|GO:0016021 SHXM_RS43945 8ba1f54fc90eaf72dd1d5201e451ac72 157 SUPERFAMILY SSF103256 3 136 2.22E-46 T 17-03-2017 IPR003729 Bifunctional nuclease domain GO:0004518 SHXM_RS43945 8ba1f54fc90eaf72dd1d5201e451ac72 157 Pfam PF02577 Bifunctional nuclease 6 128 2.7E-45 T 17-03-2017 IPR003729 Bifunctional nuclease domain GO:0004518 SHXM_RS11370 85501913d9c44e75cb61aeeebed2b1e4 106 SUPERFAMILY SSF54909 1 105 2.56E-34 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS11370 85501913d9c44e75cb61aeeebed2b1e4 106 Pfam PF05336 Domain of unknown function (DUF718) 3 105 1.6E-32 T 17-03-2017 IPR008000 Rhamnose/fucose mutarotase GO:0005737|GO:0016857 SHXM_RS37915 642ec5db5eeb819a97113366c85bdc05 385 Gene3D G3DSA:3.40.50.300 226 312 4.0E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37915 642ec5db5eeb819a97113366c85bdc05 385 Gene3D G3DSA:3.40.50.300 18 165 4.0E-10 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37915 642ec5db5eeb819a97113366c85bdc05 385 SUPERFAMILY SSF52540 18 134 2.77E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS37915 642ec5db5eeb819a97113366c85bdc05 385 SUPERFAMILY SSF52540 274 312 2.77E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS01620 db8d1dcb3ea2413cf0812ee4254dc0f7 29 TIGRFAM TIGR02115 potass_kdpF: K+-transporting ATPase, F subunit 7 29 8.1E-10 T 17-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 SHXM_RS01620 db8d1dcb3ea2413cf0812ee4254dc0f7 29 Pfam PF09604 F subunit of K+-transporting ATPase (Potass_KdpF) 6 29 1.9E-8 T 17-03-2017 IPR011726 K+ transporting P-type ATPase, F subunit GO:0005886|GO:0008556|GO:0043462 SHXM_RS00505 ba52fa54ab5166e931cf34845f1e40ab 288 Gene3D G3DSA:2.120.10.30 83 219 5.4E-6 T 17-03-2017 IPR011042 Six-bladed beta-propeller, TolB-like SHXM_RS00505 ba52fa54ab5166e931cf34845f1e40ab 288 SUPERFAMILY SSF75011 78 226 1.7E-8 T 17-03-2017 SHXM_RS28645 d9a12aa30e1954882b78dc06f2d14bdf 139 SUPERFAMILY SSF55874 39 125 2.26E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS28645 d9a12aa30e1954882b78dc06f2d14bdf 139 Gene3D G3DSA:3.30.565.10 32 121 3.8E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS14220 d9bd1cb0709999f60c6835db6617889d 95 Pfam PF00542 Ribosomal protein L7/L12 C-terminal domain 63 92 2.3E-5 T 17-03-2017 IPR013823 Ribosomal protein L7/L12, C-terminal GO:0003735|GO:0006412 Reactome: R-HSA-5368286|Reactome: R-HSA-5389840|Reactome: R-HSA-5419276 SHXM_RS14220 d9bd1cb0709999f60c6835db6617889d 95 Gene3D G3DSA:3.30.1390.10 63 91 1.2E-5 T 17-03-2017 IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like SHXM_RS13275 792ef6fcbeb85a8204443e65b26face2 154 Pfam PF13581 Histidine kinase-like ATPase domain 35 142 1.1E-15 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13275 792ef6fcbeb85a8204443e65b26face2 154 Gene3D G3DSA:3.30.565.10 37 142 5.4E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS13275 792ef6fcbeb85a8204443e65b26face2 154 SUPERFAMILY SSF55874 56 143 8.63E-11 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS08425 aa7fb6fe6432aac7b7e5e309178762ae 120 Pfam PF05331 Protein of unknown function (DUF742) 11 120 2.2E-28 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS18290 7f211adaa3fb9894f39fe913234ea84e 243 Pfam PF01988 VIT family 28 235 3.9E-62 T 17-03-2017 IPR008217 Ccc1 family SHXM_RS29380 82b271aae8881b227adbc094fe3096c5 105 ProDom PD026347 LSR2-LIKE LSR2 ANTIGEN IMMUNE PRECURSOR RESPONSE SIGNAL PLASMID LYSYL GP61 1 104 4.0E-42 T 17-03-2017 IPR024412 Lsr2 SHXM_RS29380 82b271aae8881b227adbc094fe3096c5 105 Pfam PF11774 Lsr2 2 103 8.8E-36 T 17-03-2017 IPR024412 Lsr2 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 Gene3D G3DSA:3.50.50.60 10 181 7.0E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 Gene3D G3DSA:3.50.50.60 277 352 7.0E-32 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 Pfam PF01494 FAD binding domain 11 326 9.7E-13 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 304 320 3.1E-10 T 17-03-2017 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 11 33 3.1E-10 T 17-03-2017 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 155 170 3.1E-10 T 17-03-2017 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 289 304 3.1E-10 T 17-03-2017 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 SUPERFAMILY SSF51905 11 176 2.81E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS05175 bde9b58c74a2eec142c071ec2f950e59 400 SUPERFAMILY SSF51905 276 375 2.81E-54 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS15040 65e3783f9b4791674b1d2bd5a9028d9b 102 SUPERFAMILY SSF55729 4 94 6.49E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS15040 65e3783f9b4791674b1d2bd5a9028d9b 102 Pfam PF14542 GCN5-related N-acetyl-transferase 13 92 1.1E-24 T 17-03-2017 IPR031165 Yjdj-type Gcn5-related N-acetyltransferase SHXM_RS15040 65e3783f9b4791674b1d2bd5a9028d9b 102 Gene3D G3DSA:3.40.630.30 1 95 9.2E-26 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21160 d2f86260d3a4598b207f28929eaee9e6 179 Pfam PF13527 Acetyltransferase (GNAT) domain 3 137 2.2E-10 T 17-03-2017 SHXM_RS21160 d2f86260d3a4598b207f28929eaee9e6 179 Gene3D G3DSA:3.40.630.30 2 141 1.8E-17 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS21160 d2f86260d3a4598b207f28929eaee9e6 179 SUPERFAMILY SSF55729 1 151 2.44E-23 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS44010 5ac415e3fbdd7665d328c0e29426bd3d 175 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 30 55 1.0E-4 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS44010 5ac415e3fbdd7665d328c0e29426bd3d 175 Pfam PF02861 Clp amino terminal domain, pathogenicity island component 135 163 2.8 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS44010 5ac415e3fbdd7665d328c0e29426bd3d 175 Gene3D G3DSA:1.10.1780.10 17 165 7.4E-16 T 17-03-2017 IPR004176 Clp, N-terminal GO:0019538 SHXM_RS10600 687ba31f4725bf35a8fd149d8cda7f4e 222 SUPERFAMILY SSF53335 8 207 2.19E-36 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10600 687ba31f4725bf35a8fd149d8cda7f4e 222 Gene3D G3DSA:3.40.50.150 15 199 8.0E-34 T 17-03-2017 IPR029063 S-adenosyl-L-methionine-dependent methyltransferase SHXM_RS10600 687ba31f4725bf35a8fd149d8cda7f4e 222 Pfam PF13649 Methyltransferase domain 61 151 4.2E-19 T 17-03-2017 SHXM_RS35590 abde9107192a41898752bd7bbdc6cf55 65 Pfam PF04149 Domain of unknown function (DUF397) 6 53 4.1E-18 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS16195 d66dc73700f035d2239b5d62c0df43ee 247 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 115 137 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS16195 d66dc73700f035d2239b5d62c0df43ee 247 Pfam PF01066 CDP-alcohol phosphatidyltransferase 70 137 4.9E-10 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS09760 195011bb351439bb467ed1dfe76a3ce0 114 Pfam PF13359 DDE superfamily endonuclease 27 112 3.6E-10 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS01270 42ca5c729772036c89fb3301881b993a 232 Pfam PF12697 Alpha/beta hydrolase family 9 219 2.2E-15 T 17-03-2017 IPR000073 Alpha/beta hydrolase fold-1 SHXM_RS01270 42ca5c729772036c89fb3301881b993a 232 SUPERFAMILY SSF53474 7 225 4.55E-22 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS01270 42ca5c729772036c89fb3301881b993a 232 Gene3D G3DSA:3.40.50.1820 7 226 9.5E-33 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS35430 7abcc39527eb6dce5e7861abb1c756c2 313 Pfam PF01774 UreD urease accessory protein 84 286 4.5E-44 T 17-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 SHXM_RS35430 7abcc39527eb6dce5e7861abb1c756c2 313 Hamap MF_01384 Urease accessory protein UreD [ureD]. 36 299 26.29 T 17-03-2017 IPR002669 Urease accessory protein UreD GO:0006807|GO:0016151 SHXM_RS09780 68ebad64d910ae53bb449ebb5b718aa2 115 Pfam PF13586 Transposase DDE domain 31 107 6.2E-11 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS50070 27bf31980d1eb02cf3427fbc7b9730ff 78 SUPERFAMILY SSF46689 1 76 2.69E-12 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS50070 27bf31980d1eb02cf3427fbc7b9730ff 78 Pfam PF13384 Homeodomain-like domain 17 64 9.2E-10 T 17-03-2017 SHXM_RS37685 db05af294468b2db7194e3fadad7f140 118 Pfam PF05331 Protein of unknown function (DUF742) 6 116 5.9E-37 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS03935 cc57054f79c0ce8da9547225ca179ebc 143 Gene3D G3DSA:3.30.450.30 20 133 3.2E-28 T 17-03-2017 SHXM_RS03935 cc57054f79c0ce8da9547225ca179ebc 143 SUPERFAMILY SSF103196 23 134 4.88E-22 T 17-03-2017 SHXM_RS03935 cc57054f79c0ce8da9547225ca179ebc 143 Pfam PF03259 Roadblock/LC7 domain 23 109 1.1E-16 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS03935 cc57054f79c0ce8da9547225ca179ebc 143 SMART SM00960 22 109 9.2E-18 T 17-03-2017 IPR004942 Roadblock/LAMTOR2 domain SHXM_RS27430 7e63fe9238fb6deaa9f8037eb9111090 297 Gene3D G3DSA:3.20.20.140 20 289 1.7E-60 T 17-03-2017 SHXM_RS27430 7e63fe9238fb6deaa9f8037eb9111090 297 Pfam PF04909 Amidohydrolase 22 288 1.0E-35 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS27430 7e63fe9238fb6deaa9f8037eb9111090 297 SUPERFAMILY SSF51556 21 288 5.82E-55 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS32035 dac305d565cb6f824fb955f7278134c3 297 Gene3D G3DSA:3.20.20.70 5 295 1.7E-115 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS32035 dac305d565cb6f824fb955f7278134c3 297 Pfam PF05853 beta-keto acid cleavage enzyme 7 293 4.5E-102 T 17-03-2017 IPR008567 3-keto-5-aminohexanoate cleavage enzyme GO:0016740|GO:0019475 KEGG: 00600+2.3.1.24 SHXM_RS33090 3907074199d031c25d0fd0be095d3257 335 Pfam PF14399 Butirosin biosynthesis protein H, N-terminal 14 142 4.6E-47 T 17-03-2017 IPR026935 Butirosin biosynthesis protein H, N-terminal KEGG: 00524+2.3.2.19|MetaCyc: PWY-7019 SHXM_RS33090 3907074199d031c25d0fd0be095d3257 335 Pfam PF16169 Domain of unknown function (DUF4872) 155 324 5.6E-51 T 17-03-2017 IPR032369 Domain of unknown function DUF4872 SHXM_RS25930 c353779f76a632bdf33eab09913ea412 198 SUPERFAMILY SSF52980 34 197 1.61E-17 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS25930 c353779f76a632bdf33eab09913ea412 198 Pfam PF05685 Putative restriction endonuclease 26 194 6.2E-24 T 17-03-2017 IPR008538 Domain of unknown function DUF820 SHXM_RS25930 c353779f76a632bdf33eab09913ea412 198 Gene3D G3DSA:3.90.1570.10 24 196 1.4E-19 T 17-03-2017 IPR012296 Nuclease, putative, TT1808 SHXM_RS14440 c5de14b1b609ba72e2df0a9456dd7f40 404 Pfam PF02653 Branched-chain amino acid transport system / permease component 58 388 8.1E-34 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS00290 bf3766c2d85011dc24f6fe34167af49b 274 Pfam PF14040 Deoxyribonuclease NucA/NucB 160 260 9.5E-12 T 17-03-2017 IPR029476 Deoxyribonuclease NucA/NucB SHXM_RS05555 90e8aa7aecf06601295ad160823a8972 843 Pfam PF12704 MacB-like periplasmic core domain 17 231 3.1E-15 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS05555 90e8aa7aecf06601295ad160823a8972 843 Pfam PF12704 MacB-like periplasmic core domain 486 683 5.3E-8 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS05555 90e8aa7aecf06601295ad160823a8972 843 Pfam PF02687 FtsX-like permease family 267 385 3.3E-23 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS05555 90e8aa7aecf06601295ad160823a8972 843 Pfam PF02687 FtsX-like permease family 719 835 4.1E-21 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS23465 537645575c2503683434005a6162fae8 191 Pfam PF06271 RDD family 50 183 1.1E-25 T 17-03-2017 IPR010432 RDD SHXM_RS06205 72d372cf09e170ec5f1338d5e8318f8b 131 Pfam PF11236 Protein of unknown function (DUF3037) 13 130 8.5E-44 T 17-03-2017 IPR021398 Protein of unknown function DUF3037 SHXM_RS09620 6d2a4970cbbd6491602b1b2cca8dfe23 230 Pfam PF13808 DDE_Tnp_1-associated 1 76 2.2E-7 T 17-03-2017 IPR032806 H repeat-associated protein, N-terminal SHXM_RS17280 bfd3ba282a171328afbd2c2240e1044b 172 Gene3D G3DSA:3.40.50.1240 4 171 3.9E-54 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS17280 bfd3ba282a171328afbd2c2240e1044b 172 SUPERFAMILY SSF53254 6 155 7.92E-24 T 17-03-2017 IPR029033 Histidine phosphatase superfamily SHXM_RS17280 bfd3ba282a171328afbd2c2240e1044b 172 Pfam PF00300 Histidine phosphatase superfamily (branch 1) 9 96 2.1E-8 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS17280 bfd3ba282a171328afbd2c2240e1044b 172 SMART SM00855 8 119 1.9E-4 T 17-03-2017 IPR013078 Histidine phosphatase superfamily, clade-1 SHXM_RS25655 00031a8c9c7514c457980d29bfd924e9 336 SUPERFAMILY SSF63829 44 278 3.99E-15 T 17-03-2017 SHXM_RS25655 00031a8c9c7514c457980d29bfd924e9 336 Gene3D G3DSA:2.130.10.10 43 278 1.6E-12 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS36535 b75e4c346053da3683fd26521276a538 428 ProSitePatterns PS01219 Ammonium transporters signature. 162 187 - T 17-03-2017 IPR018047 Ammonium transporter, conserved site GO:0008519|GO:0016020|GO:0072488 SHXM_RS36535 b75e4c346053da3683fd26521276a538 428 Pfam PF00909 Ammonium Transporter Family 7 396 1.4E-126 T 17-03-2017 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 SHXM_RS36535 b75e4c346053da3683fd26521276a538 428 SUPERFAMILY SSF111352 2 376 2.35E-125 T 17-03-2017 IPR024041 Ammonium transporter AmtB-like domain GO:0008519|GO:0015696|GO:0016020 SHXM_RS36535 b75e4c346053da3683fd26521276a538 428 TIGRFAM TIGR00836 amt: ammonium transporter 5 396 7.3E-136 T 17-03-2017 IPR001905 Ammonium transporter GO:0008519|GO:0016020|GO:0072488 SHXM_RS36535 b75e4c346053da3683fd26521276a538 428 Gene3D G3DSA:1.10.3430.10 2 376 7.0E-137 T 17-03-2017 IPR029020 Ammonium/urea transporter SHXM_RS49310 9338d65626235c3939b528726251f33c 334 Pfam PF07920 Protein of unknown function (DUF1684) 188 325 2.7E-22 T 17-03-2017 IPR012467 Protein of unknown function DUF1684 SHXM_RS34540 250a3054319c7823fbe50dcb963d0863 66 Pfam PF04149 Domain of unknown function (DUF397) 5 56 2.5E-11 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS15100 5ffb7ad8d87ac06b940af5bcae588682 69 Pfam PF13822 Acyl-CoA carboxylase epsilon subunit 2 62 6.5E-17 T 17-03-2017 IPR032716 Acyl-CoA carboxylase epsilon subunit SHXM_RS07075 78439813d497084168649bfec0a4aac0 140 SUPERFAMILY SSF50685 6 137 2.96E-5 T 17-03-2017 IPR009009 RlpA-like protein, double-psi beta-barrel domain SHXM_RS07075 78439813d497084168649bfec0a4aac0 140 Pfam PF03330 Lytic transglycolase 11 137 3.8E-7 T 17-03-2017 IPR009009 RlpA-like protein, double-psi beta-barrel domain SHXM_RS16965 d03945d152d1b3bc9bcbd6aba5cad246 71 Pfam PF11720 Peptidase inhibitor I78 family 17 62 8.5E-6 T 17-03-2017 IPR021719 Proteinase inhibitor I78 SHXM_RS01575 bfd3ffcfc1c00c0d5c1e4801e73ac712 160 Gene3D G3DSA:3.30.428.10 3 148 6.9E-14 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS01575 bfd3ffcfc1c00c0d5c1e4801e73ac712 160 SUPERFAMILY SSF54197 3 108 3.71E-14 T 17-03-2017 IPR011146 HIT-like domain GO:0003824 SHXM_RS44360 e0f0efdc67284284c8ab54f0cd3ebe7c 81 Gene3D G3DSA:1.10.260.40 16 66 1.6E-5 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS44360 e0f0efdc67284284c8ab54f0cd3ebe7c 81 SUPERFAMILY SSF47413 5 68 3.97E-6 T 17-03-2017 IPR010982 Lambda repressor-like, DNA-binding domain GO:0003677 SHXM_RS14460 42f258aea46d59ad42596687a2bbec34 162 Gene3D G3DSA:3.40.630.30 1 139 5.7E-32 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS14460 42f258aea46d59ad42596687a2bbec34 162 SUPERFAMILY SSF55729 1 138 6.52E-32 T 17-03-2017 IPR016181 Acyl-CoA N-acyltransferase SHXM_RS14460 42f258aea46d59ad42596687a2bbec34 162 Pfam PF00583 Acetyltransferase (GNAT) family 61 135 1.4E-17 T 17-03-2017 IPR000182 GNAT domain GO:0008080 SHXM_RS37445 d9089a5b0a20031d20624f5e3ada30ba 513 Pfam PF13830 Domain of unknown function (DUF4192) 21 362 2.7E-96 T 17-03-2017 IPR025447 Protein of unknown function DUF4192 SHXM_RS00865 bb4dd1532e3eae51f4ce2a44ded224fd 62 Gene3D G3DSA:3.40.50.1000 12 43 2.7E-5 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS00865 bb4dd1532e3eae51f4ce2a44ded224fd 62 SUPERFAMILY SSF56784 13 46 1.07E-7 T 17-03-2017 IPR023214 HAD-like domain SHXM_RS48830 aa2a839fc9f7a4a1d34eca832a9b2f32 287 Pfam PF12158 Protein of unknown function (DUF3592) 145 280 5.7E-8 T 17-03-2017 IPR021994 Protein of unknown function DUF3592 SHXM_RS25780 a9407af7a1b6c53e3521d119f000fa1e 156 Pfam PF04892 VanZ like family 24 126 1.3E-21 T 17-03-2017 IPR006976 VanZ-like SHXM_RS08985 9a8aa95c2269d37809e89318259afa5c 380 Pfam PF13006 Insertion element 4 transposase N-terminal 2 93 3.6E-30 T 17-03-2017 IPR024473 Transposase, IS4, N-terminal SHXM_RS08985 9a8aa95c2269d37809e89318259afa5c 380 Pfam PF01609 Transposase DDE domain 110 336 7.3E-19 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS08985 9a8aa95c2269d37809e89318259afa5c 380 SUPERFAMILY SSF53098 108 350 4.55E-24 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS27830 9eb35744bf820dcb1e2a0f6d674ec1f1 290 Pfam PF02498 BRO family, N-terminal domain 31 122 1.3E-14 T 17-03-2017 IPR003497 BRO N-terminal domain SHXM_RS27830 9eb35744bf820dcb1e2a0f6d674ec1f1 290 SMART SM01040 30 127 5.5E-23 T 17-03-2017 IPR003497 BRO N-terminal domain SHXM_RS27830 9eb35744bf820dcb1e2a0f6d674ec1f1 290 Gene3D G3DSA:1.10.10.10 226 274 1.4E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS09345 2357ae9489b3f9bb9effa7326b395390 454 ProSitePatterns PS00218 Amino acid permeases signature. 23 53 - T 17-03-2017 IPR004840 Amino acid permease, conserved site GO:0006865|GO:0016021|GO:0055085 SHXM_RS09345 2357ae9489b3f9bb9effa7326b395390 454 Pfam PF00324 Amino acid permease 1 404 8.3E-104 T 17-03-2017 IPR004841 Amino acid permease/ SLC12A domain GO:0006810|GO:0016020|GO:0055085 SHXM_RS09345 2357ae9489b3f9bb9effa7326b395390 454 PIRSF PIRSF006060 1 443 2.4E-55 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS04445 cf1afad6505546cd26322fe53d7f58ab 534 Pfam PF07905 Purine catabolism regulatory protein-like family 8 129 3.5E-37 T 17-03-2017 IPR012914 Purine catabolism PurC-like domain SHXM_RS04445 cf1afad6505546cd26322fe53d7f58ab 534 Pfam PF13556 PucR C-terminal helix-turn-helix domain 463 519 5.8E-13 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS47915 9015aa8171c783dca5b5fd328be2a287 269 Pfam PF00378 Enoyl-CoA hydratase/isomerase 20 256 5.0E-46 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS47915 9015aa8171c783dca5b5fd328be2a287 269 Gene3D G3DSA:3.90.226.10 8 233 7.0E-67 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS47915 9015aa8171c783dca5b5fd328be2a287 269 SUPERFAMILY SSF52096 13 256 1.86E-66 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS28600 8301309ef840ce6c53f2ba20ffaed0af 119 Pfam PF05331 Protein of unknown function (DUF742) 8 119 1.3E-32 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS30360 0ef40234d7f07eff3dc2f7c1b707a8a3 513 Pfam PF00916 Sulfate permease family 24 391 3.7E-56 T 17-03-2017 IPR011547 SLC26A/SulP transporter domain GO:0008272|GO:0015116|GO:0016021 SHXM_RS23315 accb074876ed771416fb7371ebbfe047 254 SUPERFAMILY SSF63817 99 243 3.01E-30 T 17-03-2017 IPR023365 Sortase domain SHXM_RS23315 accb074876ed771416fb7371ebbfe047 254 Gene3D G3DSA:2.40.260.10 100 244 3.9E-27 T 17-03-2017 IPR023365 Sortase domain SHXM_RS23315 accb074876ed771416fb7371ebbfe047 254 Pfam PF04203 Sortase family 106 242 6.9E-27 T 17-03-2017 IPR005754 Sortase family SHXM_RS19920 ede5f3ffa5450edaeef584685d92eac6 432 Pfam PF14378 PAP2 superfamily 157 345 1.7E-17 T 17-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 SHXM_RS50385 0771206b730d0d65648de2c1571c1d56 207 Gene3D G3DSA:1.10.10.10 138 194 7.7E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS31505 27a1087cb62ba84306857b183a68613c 70 Pfam PF04149 Domain of unknown function (DUF397) 4 57 1.4E-13 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS47360 de12ad06aff5a62e22fdf4a6641d3cc3 277 Pfam PF02585 GlcNAc-PI de-N-acetylase 9 156 4.4E-27 T 17-03-2017 IPR003737 N-acetylglucosaminyl phosphatidylinositol deacetylase-related Reactome: R-HSA-162710 SHXM_RS47360 de12ad06aff5a62e22fdf4a6641d3cc3 277 Gene3D G3DSA:3.40.50.10320 6 276 1.3E-75 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS47360 de12ad06aff5a62e22fdf4a6641d3cc3 277 SUPERFAMILY SSF102588 5 276 3.14E-62 T 17-03-2017 IPR024078 Putative deacetylase LmbE-like domain Reactome: R-HSA-162710 SHXM_RS23110 d5b1dfad42561094aa75dc297d18a174 330 Gene3D G3DSA:3.10.129.10 210 325 4.1E-5 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23110 d5b1dfad42561094aa75dc297d18a174 330 SUPERFAMILY SSF54637 194 324 2.29E-5 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23330 81e20156fbe07ea97677e0bee3d8eeab 248 Pfam PF08044 Domain of unknown function (DUF1707) 1 53 4.7E-25 T 17-03-2017 IPR012551 Protein of unknown function DUF1707 SHXM_RS46070 0726074a63f36210d4ef9d133938ae35 97 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 26 83 2.7E-18 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS03315 1e89d5a56ee85570038f94c08113ccf1 392 SUPERFAMILY SSF111321 67 366 9.94E-46 T 17-03-2017 IPR002791 Domain of unknown function DUF89 SHXM_RS03315 1e89d5a56ee85570038f94c08113ccf1 392 Pfam PF01937 Protein of unknown function DUF89 23 370 1.1E-80 T 17-03-2017 IPR002791 Domain of unknown function DUF89 SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 Gene3D G3DSA:3.40.50.300 623 645 9.6E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 Gene3D G3DSA:3.40.50.300 422 557 9.6E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 Gene3D G3DSA:3.40.50.300 683 744 9.6E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 Gene3D G3DSA:3.40.50.300 862 958 2.8E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 SUPERFAMILY SSF52540 616 646 1.09E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 SUPERFAMILY SSF52540 457 513 1.09E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 SUPERFAMILY SSF52540 684 737 1.09E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS35055 1a2d58b02a893ea95a0e861fb993e75f 1108 SUPERFAMILY SSF52540 864 952 1.09E-19 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS41300 10b5ba117d9388b213bfe222e1ebc227 389 Gene3D G3DSA:3.40.640.10 50 257 2.0E-65 T 17-03-2017 IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1 GO:0003824 SHXM_RS41300 10b5ba117d9388b213bfe222e1ebc227 389 Gene3D G3DSA:3.90.1150.10 258 385 3.3E-37 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS41300 10b5ba117d9388b213bfe222e1ebc227 389 Pfam PF00155 Aminotransferase class I and II 36 380 1.2E-65 T 17-03-2017 IPR004839 Aminotransferase, class I/classII GO:0009058|GO:0030170 SHXM_RS41300 10b5ba117d9388b213bfe222e1ebc227 389 SUPERFAMILY SSF53383 27 385 1.33E-106 T 17-03-2017 IPR015424 Pyridoxal phosphate-dependent transferase SHXM_RS42770 9c8c8da49eb93b232347ca9bc1a14222 228 Gene3D G3DSA:1.20.1260.10 74 227 1.0E-51 T 17-03-2017 IPR012347 Ferritin-related SHXM_RS42770 9c8c8da49eb93b232347ca9bc1a14222 228 Pfam PF03713 Domain of unknown function (DUF305) 79 227 6.5E-49 T 17-03-2017 IPR005183 Domain of unknown function DUF305 SHXM_RS36215 b63a6fd64ce38e3d049bbabbbb427e3c 413 Gene3D G3DSA:1.10.10.60 344 381 5.4E-7 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS36215 b63a6fd64ce38e3d049bbabbbb427e3c 413 Pfam PF13556 PucR C-terminal helix-turn-helix domain 347 405 9.3E-20 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS10035 f6c868e1d841ddcb38babbff44c1e2a4 447 SUPERFAMILY SSF54060 248 290 6.47E-10 T 17-03-2017 SHXM_RS10035 f6c868e1d841ddcb38babbff44c1e2a4 447 Pfam PF02945 Recombination endonuclease VII 249 285 4.7E-9 T 17-03-2017 IPR004211 Recombination endonuclease VII SHXM_RS01840 7085813c09109af61b4a59b64c15e8d5 346 SUPERFAMILY SSF53300 10 142 4.45E-11 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS01840 7085813c09109af61b4a59b64c15e8d5 346 Gene3D G3DSA:3.40.50.410 11 140 3.8E-5 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS12585 0082279533857af72618e722f101c65b 222 Pfam PF01066 CDP-alcohol phosphatidyltransferase 27 91 3.7E-10 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS12585 0082279533857af72618e722f101c65b 222 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 69 91 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS37865 1e0f3850a7f7c0af20ef65a5c4307222 262 PIRSF PIRSF006648 1 261 1.2E-64 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS37865 1e0f3850a7f7c0af20ef65a5c4307222 262 Pfam PF01061 ABC-2 type transporter 8 214 4.7E-31 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS19290 607cbd9a49c9d0f3a6b0b9a24a66ef8e 270 Pfam PF14378 PAP2 superfamily 66 247 1.3E-44 T 17-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 SHXM_RS05905 87e0970397c7b399448531989d701c25 279 Pfam PF12706 Beta-lactamase superfamily domain 29 233 1.7E-12 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS05905 87e0970397c7b399448531989d701c25 279 Gene3D G3DSA:3.60.15.10 2 272 6.7E-35 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS05905 87e0970397c7b399448531989d701c25 279 SUPERFAMILY SSF56281 11 250 5.32E-23 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS20480 363e53db5405e0ebac2e186adb01f082 141 TIGRFAM TIGR03562 osmo_induc_OsmC: peroxiredoxin, OsmC subfamily 4 138 3.5E-53 T 17-03-2017 IPR019904 Peroxiredoxin OsmC GO:0004601|GO:0006979 KEGG: 00480+1.11.1.15 SHXM_RS20480 363e53db5405e0ebac2e186adb01f082 141 Gene3D G3DSA:3.30.300.20 4 140 5.0E-45 T 17-03-2017 IPR015946 K homology domain-like, alpha/beta SHXM_RS20480 363e53db5405e0ebac2e186adb01f082 141 SUPERFAMILY SSF82784 1 131 7.72E-33 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS20480 363e53db5405e0ebac2e186adb01f082 141 Pfam PF02566 OsmC-like protein 44 136 2.6E-19 T 17-03-2017 IPR003718 OsmC/Ohr family SHXM_RS29215 a9f94c8a84ac1240518f728980a363f2 196 Pfam PF10936 Protein of unknown function DUF2617 3 163 5.1E-59 T 17-03-2017 IPR024486 Protein of unknown function DUF2617 SHXM_RS29215 a9f94c8a84ac1240518f728980a363f2 196 ProDom PD339375 PRECURSOR SIGNAL SCO3656 SCO2458 CGL2705 MB2629 RV2598/MT2673.1 4 170 3.0E-65 T 17-03-2017 IPR024486 Protein of unknown function DUF2617 SHXM_RS30605 d0e6c9f294b5fac71cb74b36831c7c1c 394 Gene3D G3DSA:3.20.20.370 65 374 3.6E-9 T 17-03-2017 IPR002509 NodB homology domain GO:0005975|GO:0016810 SHXM_RS30605 d0e6c9f294b5fac71cb74b36831c7c1c 394 SUPERFAMILY SSF88713 66 110 5.72E-25 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS30605 d0e6c9f294b5fac71cb74b36831c7c1c 394 SUPERFAMILY SSF88713 140 373 5.72E-25 T 17-03-2017 IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel GO:0003824|GO:0005975 SHXM_RS25035 5ece324b9db44a80d929557ef012e2b1 366 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 116 269 2.6E-41 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS25035 5ece324b9db44a80d929557ef012e2b1 366 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 116 269 2.4E-47 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS36950 6b5c355234cd9a8189da2c0574cf7888 974 Gene3D G3DSA:3.40.50.300 624 857 7.3E-26 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36950 6b5c355234cd9a8189da2c0574cf7888 974 SUPERFAMILY SSF52540 623 859 2.31E-24 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS36950 6b5c355234cd9a8189da2c0574cf7888 974 Pfam PF13614 AAA domain 625 772 3.2E-10 T 17-03-2017 IPR025669 AAA domain SHXM_RS28290 8346bdc22dada50be44e9c83b177122b 514 Pfam PF10009 Uncharacterized protein conserved in bacteria (DUF2252) 103 500 1.3E-131 T 17-03-2017 IPR018721 Protein of unknown function DUF2252 SHXM_RS19695 c94eaaf6f780df5ec868a0a21c31e476 267 Pfam PF03883 Protein of unknown function (DUF328) 2 247 4.1E-39 T 17-03-2017 IPR005583 Peroxide stress protein YaaA SHXM_RS11825 45bcdfa661e6581cdff2559a58a31295 125 Pfam PF05610 Protein of unknown function (DUF779) 20 119 1.4E-46 T 17-03-2017 IPR008497 Protein of unknown function DUF779 SHXM_RS11825 45bcdfa661e6581cdff2559a58a31295 125 PIRSF PIRSF009151 2 125 1.7E-58 T 17-03-2017 IPR008497 Protein of unknown function DUF779 SHXM_RS10910 4dc4b0203865ea8f981fc6b511c52f9a 301 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 122 289 1.4E-23 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10910 4dc4b0203865ea8f981fc6b511c52f9a 301 Gene3D G3DSA:1.10.3720.10 111 289 1.4E-21 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS10910 4dc4b0203865ea8f981fc6b511c52f9a 301 SUPERFAMILY SSF161098 98 277 3.27E-29 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS49470 83a3c0fe03f2d14ed4af031b85a12ead 299 SUPERFAMILY SSF51338 4 55 3.7E-9 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS49470 83a3c0fe03f2d14ed4af031b85a12ead 299 Gene3D G3DSA:2.30.40.10 1 110 1.4E-12 T 17-03-2017 IPR011059 Metal-dependent hydrolase, composite domain GO:0016810 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 Gene3D G3DSA:3.50.50.60 272 347 5.8E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 Gene3D G3DSA:3.50.50.60 4 175 5.8E-28 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 Pfam PF01494 FAD binding domain 6 343 1.2E-20 T 17-03-2017 IPR002938 FAD-binding domain GO:0071949 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 SUPERFAMILY SSF51905 5 170 2.06E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 SUPERFAMILY SSF51905 271 360 2.06E-51 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 5 27 1.2E-14 T 17-03-2017 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 299 315 1.2E-14 T 17-03-2017 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 149 164 1.2E-14 T 17-03-2017 SHXM_RS48650 bf2aba977ccbc0581200ca03cb7f263a 409 PRINTS PR00420 Aromatic-ring hydroxylase (flavoprotein monooxygenase) signature 284 299 1.2E-14 T 17-03-2017 SHXM_RS47365 16b2e46aa995a11e1caaeb251a418d01 176 Gene3D G3DSA:1.20.1250.20 23 94 9.5E-4 T 17-03-2017 SHXM_RS46300 a2d6aad53e73e013db3482a464749f3d 152 SUPERFAMILY SSF46785 2 146 1.03E-12 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS46300 a2d6aad53e73e013db3482a464749f3d 152 Gene3D G3DSA:1.10.10.10 13 141 2.7E-15 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS50475 cce15870d9665f02cebbc69307864be0 280 Pfam PF13701 Transposase DDE domain group 1 59 173 2.0E-19 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS27300 0ace330342c0fdf91176052e36ae0617 99 PIRSF PIRSF006909 1 99 3.3E-58 T 17-03-2017 IPR014447 Uncharacterised conserved protein UCP006909 SHXM_RS04245 08fa054488ca87757a2618e46f112f66 378 Pfam PF12671 Putative amidase domain 224 375 2.3E-35 T 17-03-2017 IPR024301 Putative amidase domain SHXM_RS34225 a01dcf1a01ef689d5862d036d7a80b9f 502 SUPERFAMILY SSF55486 360 491 1.4E-12 T 17-03-2017 SHXM_RS34225 a01dcf1a01ef689d5862d036d7a80b9f 502 Pfam PF11350 Protein of unknown function (DUF3152) 319 500 5.1E-58 T 17-03-2017 IPR022603 Domain of unknown function DUF3152 SHXM_RS30615 6fe9657b8b18cafaeff9401807e35699 254 Pfam PF02683 Cytochrome C biogenesis protein transmembrane region 26 233 1.8E-47 T 17-03-2017 IPR003834 Cytochrome C biogenesis protein, transmembrane domain GO:0016020|GO:0017004|GO:0055114 SHXM_RS44995 14e0d63451928a87b43c22f0dc4c5e95 363 SUPERFAMILY SSF52266 158 349 1.47E-16 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS44995 14e0d63451928a87b43c22f0dc4c5e95 363 Pfam PF14606 GDSL-like Lipase/Acylhydrolase family 166 315 6.7E-14 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS44995 14e0d63451928a87b43c22f0dc4c5e95 363 Gene3D G3DSA:3.40.50.1110 151 350 1.7E-8 T 17-03-2017 IPR013830 SGNH hydrolase-type esterase domain SHXM_RS07915 2e1a203c35235eb6e753d02abc9b3301 70 Pfam PF00741 Gas vesicle protein 11 49 2.0E-15 T 17-03-2017 IPR000638 Gas vesicle protein GvpA GO:0005198|GO:0012506 SHXM_RS42535 d2a55eb7d59348d93d2e6d6abe773b0f 384 Pfam PF01384 Phosphate transporter family 22 161 2.6E-35 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS42535 d2a55eb7d59348d93d2e6d6abe773b0f 384 Pfam PF01384 Phosphate transporter family 164 320 1.4E-45 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS00415 8f3fe72a3578f494bb6482b0f150830b 294 Pfam PF14015 Protein of unknown function (DUF4231) 20 108 4.1E-11 T 17-03-2017 IPR025325 Protein of unknown function DUF4231 SHXM_RS41705 203e1f31df79952cc570cba441fc5085 358 Pfam PF02653 Branched-chain amino acid transport system / permease component 54 314 6.1E-33 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS39035 f006f9ce87e5f1a1b3b0c27835b38429 285 Gene3D G3DSA:1.10.10.10 224 266 1.0E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS13105 a8d7544c33af97372bf6e0aff81891e2 192 PRINTS PR01217 Proline rich extensin signature 64 80 1.8E-9 T 17-03-2017 SHXM_RS13105 a8d7544c33af97372bf6e0aff81891e2 192 PRINTS PR01217 Proline rich extensin signature 2 18 1.8E-9 T 17-03-2017 SHXM_RS13105 a8d7544c33af97372bf6e0aff81891e2 192 PRINTS PR01217 Proline rich extensin signature 133 158 1.8E-9 T 17-03-2017 SHXM_RS13105 a8d7544c33af97372bf6e0aff81891e2 192 PRINTS PR01217 Proline rich extensin signature 91 108 1.8E-9 T 17-03-2017 SHXM_RS26440 b4aa791441420ecac884858c57208749 165 Pfam PF11377 Protein of unknown function (DUF3180) 9 150 3.9E-34 T 17-03-2017 IPR021517 Protein of unknown function DUF3180 SHXM_RS47455 f3b3356d3b5564c8eb5f9ec8cc62fb12 249 Pfam PF01925 Sulfite exporter TauE/SafE 8 243 8.5E-42 T 17-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 SHXM_RS20695 af2abd9b128a584ff5c98cb8dce86d2a 121 Pfam PF05331 Protein of unknown function (DUF742) 8 119 5.2E-30 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS36745 c121ec6f611e0ab89c0c73049f79388a 429 SUPERFAMILY SSF50939 195 339 5.56E-10 T 17-03-2017 IPR011040 Sialidases Reactome: R-HSA-1660662|Reactome: R-HSA-4085001 SHXM_RS36745 c121ec6f611e0ab89c0c73049f79388a 429 Gene3D G3DSA:2.130.10.10 112 352 1.3E-9 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS19835 b359f064f9055c23fbc4dab56a5a3e0e 424 SUPERFAMILY SSF48239 57 188 5.76E-20 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS19835 b359f064f9055c23fbc4dab56a5a3e0e 424 Gene3D G3DSA:1.50.10.20 56 223 3.5E-18 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS19835 b359f064f9055c23fbc4dab56a5a3e0e 424 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 125 167 5.7E-10 T 17-03-2017 IPR001330 PFTB repeat GO:0003824 SHXM_RS19835 b359f064f9055c23fbc4dab56a5a3e0e 424 Pfam PF00432 Prenyltransferase and squalene oxidase repeat 71 120 0.22 T 17-03-2017 IPR001330 PFTB repeat GO:0003824 SHXM_RS27225 8452daf406e2d15176c5e16a4a869606 840 Pfam PF02687 FtsX-like permease family 728 832 4.8E-7 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS27225 8452daf406e2d15176c5e16a4a869606 840 Pfam PF02687 FtsX-like permease family 276 388 2.6E-10 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS27140 0057bd5fc930b088296f6dafba21a164 221 Pfam PF16702 Domain of unknown function (DUF5063) 13 173 8.2E-44 T 17-03-2017 IPR032025 Protein of unknown function DUF5063 SHXM_RS32130 9807bb13bd736a8eb578383cfeb911c6 577 Pfam PF02538 Hydantoinase B/oxoprolinase 8 527 3.5E-151 T 17-03-2017 IPR003692 Hydantoinase B/oxoprolinase GO:0003824 Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS34575 0a3e324c7b2975ab0432545f09bb34b7 86 Pfam PF11755 Protein of unknown function (DUF3311) 24 82 4.2E-24 T 17-03-2017 IPR021741 Protein of unknown function DUF3311 SHXM_RS08790 a5287b868abb37bb1c93d20d47b11636 336 Pfam PF13814 Replication-relaxation 52 236 8.1E-40 T 17-03-2017 IPR025855 Plasmid replication-relaxation SHXM_RS12135 82030b96edf16aecd33e7f5f1948a715 151 Pfam PF10756 Bacterial PH domain 68 138 2.6E-16 T 17-03-2017 IPR019692 Protein of unknown function DUF2581 SHXM_RS09765 389b45e3325408e4cf6667e49177882f 49 Pfam PF13359 DDE superfamily endonuclease 1 42 1.0E-5 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS44680 049bd9161637ccb6724b08ecdad578dc 263 Pfam PF05257 CHAP domain 37 126 2.0E-9 T 17-03-2017 IPR007921 CHAP domain SHXM_RS44680 049bd9161637ccb6724b08ecdad578dc 263 SUPERFAMILY SSF54001 41 129 2.16E-6 T 17-03-2017 SHXM_RS20240 1f561fd01011f5ceeee07ab5221a19bf 135 Pfam PF03995 Peptidase inhibitor family I36 41 109 3.0E-8 T 17-03-2017 SHXM_RS38485 c82431f4ca2d722868751830e8455a1a 158 SUPERFAMILY SSF52402 17 145 3.42E-20 T 17-03-2017 SHXM_RS38485 c82431f4ca2d722868751830e8455a1a 158 Gene3D G3DSA:3.40.50.620 40 144 4.9E-12 T 17-03-2017 IPR014729 Rossmann-like alpha/beta/alpha sandwich fold SHXM_RS38830 ea042937bc271740500028160ffb9643 156 Pfam PF13581 Histidine kinase-like ATPase domain 33 148 2.3E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS38830 ea042937bc271740500028160ffb9643 156 SUPERFAMILY SSF55874 53 149 1.32E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS37245 dc398eca63c25e129dd933ccd84e62e7 203 Hamap MF_01114 Regulatory protein RecX [recX]. 37 189 15.313 T 17-03-2017 IPR003783 Regulatory protein RecX GO:0006282 SHXM_RS37245 dc398eca63c25e129dd933ccd84e62e7 203 Gene3D G3DSA:1.10.10.10 88 133 5.7E-8 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS37245 dc398eca63c25e129dd933ccd84e62e7 203 Pfam PF02631 RecX family 64 184 4.5E-28 T 17-03-2017 IPR003783 Regulatory protein RecX GO:0006282 SHXM_RS47885 9d1ee3cfa64429965edf09de86f0426e 108 Gene3D G3DSA:1.20.1290.10 5 107 1.1E-26 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS47885 9d1ee3cfa64429965edf09de86f0426e 108 Pfam PF02627 Carboxymuconolactone decarboxylase family 20 103 1.4E-23 T 17-03-2017 IPR003779 Carboxymuconolactone decarboxylase-like GO:0051920|GO:0055114 KEGG: 00480+1.11.1.15 SHXM_RS47885 9d1ee3cfa64429965edf09de86f0426e 108 SUPERFAMILY SSF69118 12 106 7.91E-30 T 17-03-2017 IPR029032 AhpD-like Reactome: R-HSA-5628897 SHXM_RS24595 048dbb4d56ab3a0ddb4a71a32ff73ffb 381 Pfam PF11991 Tryptophan dimethylallyltransferase 38 316 3.1E-10 T 17-03-2017 IPR017795 Aromatic prenyltransferase, DMATS type GO:0009820|GO:0050364 SHXM_RS29420 2d8fbbd606ea2c1e8701bf9744068310 84 Pfam PF11273 Protein of unknown function (DUF3073) 2 62 9.3E-20 T 17-03-2017 IPR021426 Protein of unknown function DUF3073 SHXM_RS00640 35c5f40bd3ee2a76ad79956eecf24bce 166 Gene3D G3DSA:1.20.1250.20 117 142 9.7E-12 T 17-03-2017 SHXM_RS00640 35c5f40bd3ee2a76ad79956eecf24bce 166 Gene3D G3DSA:1.20.1250.20 2 65 9.7E-12 T 17-03-2017 SHXM_RS00640 35c5f40bd3ee2a76ad79956eecf24bce 166 SUPERFAMILY SSF103473 3 64 2.09E-9 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS00640 35c5f40bd3ee2a76ad79956eecf24bce 166 SUPERFAMILY SSF103473 116 143 2.09E-9 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS08650 9f220786d96c41af5d86e082158da2a9 177 PIRSF PIRSF010260 3 177 2.0E-60 T 17-03-2017 IPR014457 Uncharacterised conserved protein UCP010260 SHXM_RS08650 9f220786d96c41af5d86e082158da2a9 177 Pfam PF09348 Domain of unknown function (DUF1990) 14 169 2.4E-57 T 17-03-2017 IPR018960 Domain of unknown function DUF1990 SHXM_RS35745 afd019ec367cae1295f06d636cff32fb 78 Pfam PF04149 Domain of unknown function (DUF397) 17 68 1.4E-11 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS20020 545005008b27d187497c87d9cb477802 232 SUPERFAMILY SSF53955 36 177 1.61E-28 T 17-03-2017 IPR023346 Lysozyme-like domain SHXM_RS20020 545005008b27d187497c87d9cb477802 232 Pfam PF01464 Transglycosylase SLT domain 60 170 1.6E-10 T 17-03-2017 IPR008258 Transglycosylase SLT domain 1 SHXM_RS20020 545005008b27d187497c87d9cb477802 232 Gene3D G3DSA:1.10.530.10 40 178 3.1E-26 T 17-03-2017 SHXM_RS09700 6b889ed3ecdfde84f940bd332fda3c32 197 Pfam PF03029 Conserved hypothetical ATP binding protein 21 165 6.7E-17 T 17-03-2017 IPR004130 GPN-loop GTPase SHXM_RS09700 6b889ed3ecdfde84f940bd332fda3c32 197 SUPERFAMILY SSF52540 15 190 4.78E-15 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS09700 6b889ed3ecdfde84f940bd332fda3c32 197 Gene3D G3DSA:3.40.50.300 13 190 8.3E-11 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS07950 261a1ce7f36da501ac525da0ee061fe3 334 SUPERFAMILY SSF55961 111 253 5.71E-18 T 17-03-2017 SHXM_RS07950 261a1ce7f36da501ac525da0ee061fe3 334 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport 119 247 2.2E-8 T 17-03-2017 IPR005031 Coenzyme Q-binding protein COQ10, START domain SHXM_RS27070 50eda25f3f5ba94941daac8d1fe0c549 191 Pfam PF02342 TerD domain 3 187 1.9E-84 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS27070 50eda25f3f5ba94941daac8d1fe0c549 191 Gene3D G3DSA:2.60.60.30 18 184 1.4E-74 T 17-03-2017 SHXM_RS16345 55fb5b2b46ae9e473f32e52e6115c52e 340 SUPERFAMILY SSF56112 7 313 7.51E-65 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS16345 55fb5b2b46ae9e473f32e52e6115c52e 340 Gene3D G3DSA:3.90.1200.10 110 296 1.0E-35 T 17-03-2017 SHXM_RS16345 55fb5b2b46ae9e473f32e52e6115c52e 340 Pfam PF01636 Phosphotransferase enzyme family 34 250 7.4E-49 T 17-03-2017 IPR002575 Aminoglycoside phosphotransferase SHXM_RS01570 53c8b4be8268141b87e6db95a2ddb1cb 97 Gene3D G3DSA:1.10.10.10 2 31 3.7E-4 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS18445 f6fbde49a8b1f122d9dc11330d48e7f0 275 Pfam PF01061 ABC-2 type transporter 50 235 5.5E-12 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS22945 6505617118b22c9521bcd5c91aff9477 624 Pfam PF04185 Phosphoesterase family 51 512 1.2E-79 T 17-03-2017 IPR007312 Phosphoesterase GO:0016788 SHXM_RS01550 b5d993faf2c273478a0d61e76f8651d3 52 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 6 52 2.2E-17 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS13995 96b8cb4c2d706b4a5cf743a7f42e393f 727 Pfam PF01204 Trehalase 415 694 2.9E-15 T 17-03-2017 IPR001661 Glycoside hydrolase, family 37 GO:0004555|GO:0005991 KEGG: 00500+3.2.1.28|Reactome: R-HSA-189085 SHXM_RS13995 96b8cb4c2d706b4a5cf743a7f42e393f 727 SUPERFAMILY SSF48208 313 717 1.42E-88 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS30070 9ea2221fa80c183d47e575ca5e57902b 187 SUPERFAMILY SSF50814 7 165 1.31E-41 T 17-03-2017 IPR011038 Calycin-like SHXM_RS30070 9ea2221fa80c183d47e575ca5e57902b 187 Pfam PF08768 Domain of unknown function (DUF1794) 12 164 6.7E-48 T 17-03-2017 IPR014878 Domain of unknown function DUF1794 SHXM_RS30070 9ea2221fa80c183d47e575ca5e57902b 187 Hamap MF_01297 UPF0678 fatty acid-binding protein-like protein . 4 166 31.84 T 17-03-2017 IPR022939 Uncharacterised protein family UPF0678 SHXM_RS48915 b8e1fea227627a82d82a6e47da017c9b 272 Pfam PF00378 Enoyl-CoA hydratase/isomerase 18 261 2.9E-50 T 17-03-2017 IPR001753 Crotonase superfamily GO:0003824|GO:0008152 SHXM_RS48915 b8e1fea227627a82d82a6e47da017c9b 272 SUPERFAMILY SSF52096 8 262 3.17E-69 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS48915 b8e1fea227627a82d82a6e47da017c9b 272 Gene3D G3DSA:3.90.226.10 11 258 1.0E-69 T 17-03-2017 IPR029045 ClpP/crotonase-like domain SHXM_RS18900 c42d70ad6a3a5a16afd84850e673bef8 132 PIRSF PIRSF017385 1 131 5.0E-52 T 17-03-2017 IPR021050 Cytochrome c oxidase subunit IV, actinobacteria GO:0004129|GO:0016021|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 SHXM_RS18900 c42d70ad6a3a5a16afd84850e673bef8 132 Pfam PF12270 Cytochrome c oxidase subunit IV 2 129 2.1E-54 T 17-03-2017 IPR021050 Cytochrome c oxidase subunit IV, actinobacteria GO:0004129|GO:0016021|GO:0055114 KEGG: 00190+1.9.3.1|MetaCyc: PWY-3781|MetaCyc: PWY-4521|MetaCyc: PWY-6692|MetaCyc: PWY-7279 SHXM_RS27835 6c6a676d651a17b44d1fea2ea4732b6f 589 Hamap MF_00089 Phosphomethylpyrimidine synthase [thiC]. 127 554 55.845 T 17-03-2017 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 SHXM_RS27835 6c6a676d651a17b44d1fea2ea4732b6f 589 Pfam PF13667 ThiC-associated domain 18 81 8.6E-21 T 17-03-2017 IPR025747 ThiC-associated domain KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 SHXM_RS27835 6c6a676d651a17b44d1fea2ea4732b6f 589 Pfam PF01964 Radical SAM ThiC family 128 548 9.7E-200 T 17-03-2017 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 SHXM_RS27835 6c6a676d651a17b44d1fea2ea4732b6f 589 TIGRFAM TIGR00190 thiC: phosphomethylpyrimidine synthase 127 551 4.3E-212 T 17-03-2017 IPR002817 Phosphomethylpyrimidine synthase GO:0009228|GO:0051536 KEGG: 00730+4.1.99.17|MetaCyc: PWY-6890 SHXM_RS48480 72bf03f4f4d87491856befa8fba1174a 307 Pfam PF07859 alpha/beta hydrolase fold 70 272 5.0E-55 T 17-03-2017 IPR013094 Alpha/beta hydrolase fold-3 GO:0008152|GO:0016787 SHXM_RS48480 72bf03f4f4d87491856befa8fba1174a 307 Gene3D G3DSA:3.40.50.1820 52 293 3.3E-67 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS48480 72bf03f4f4d87491856befa8fba1174a 307 SUPERFAMILY SSF53474 13 294 1.64E-55 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS48480 72bf03f4f4d87491856befa8fba1174a 307 ProSitePatterns PS01174 Lipolytic enzymes "G-D-X-G" family, putative serine active site. 138 150 - T 17-03-2017 IPR033140 Lipase, GDXG, putative serine active site SHXM_RS39095 0aead871a7ad0acde457b6295197bc02 349 Pfam PF02653 Branched-chain amino acid transport system / permease component 58 334 4.2E-52 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS36650 3ae8038019eb024f02fbb15cff900d46 250 SUPERFAMILY SSF51261 108 216 4.34E-14 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS36650 3ae8038019eb024f02fbb15cff900d46 250 Pfam PF01551 Peptidase family M23 115 212 1.9E-12 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS36650 3ae8038019eb024f02fbb15cff900d46 250 Gene3D G3DSA:2.70.70.10 78 217 1.1E-21 T 17-03-2017 SHXM_RS41175 1c9dfb9dca2a8efef3ff081fbf766efc 270 Pfam PF01925 Sulfite exporter TauE/SafE 9 265 3.8E-39 T 17-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 SHXM_RS26400 11eacc77b63522b5a5f485814afcf3ad 227 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 42 220 6.6E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26400 11eacc77b63522b5a5f485814afcf3ad 227 Gene3D G3DSA:1.10.3720.10 20 205 3.2E-29 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS26400 11eacc77b63522b5a5f485814afcf3ad 227 SUPERFAMILY SSF161098 24 206 1.31E-35 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS50820 76820942652652cc8a3334ab9090a697 279 Pfam PF03457 Helicase associated domain 9 56 6.2E-10 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS50820 76820942652652cc8a3334ab9090a697 279 Pfam PF03457 Helicase associated domain 157 214 4.3E-12 T 17-03-2017 IPR005114 Helicase-associated SHXM_RS41490 565fdf003a168b80de85877a46727d4f 232 Pfam PF14016 Protein of unknown function (DUF4232) 95 223 3.7E-26 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS32195 483c66ab600ef5068802c3f2405bdc8a 348 Gene3D G3DSA:3.40.220.10 132 340 3.2E-13 T 17-03-2017 SHXM_RS32195 483c66ab600ef5068802c3f2405bdc8a 348 SUPERFAMILY SSF52949 144 339 1.26E-14 T 17-03-2017 SHXM_RS32565 9167de8778950c7c13c74006a1c1bc0e 254 Pfam PF02361 Cobalt transport protein 14 218 3.3E-31 T 17-03-2017 IPR003339 ABC/ECF transporter, transmembrane component SHXM_RS32565 9167de8778950c7c13c74006a1c1bc0e 254 TIGRFAM TIGR02454 ECF_T_CbiQ: cobalt ECF transporter T component CbiQ 21 214 4.5E-48 T 17-03-2017 IPR012809 Cobalt ECF transporter T component CbiQ GO:0005887|GO:0006824|GO:0043190 SHXM_RS24685 6b16f30d85609e0ad56b137268d9d37d 68 Pfam PF13822 Acyl-CoA carboxylase epsilon subunit 2 61 3.9E-19 T 17-03-2017 IPR032716 Acyl-CoA carboxylase epsilon subunit SHXM_RS32495 f6c9c71b899dfa447017dc7ec9f7a146 351 Gene3D G3DSA:2.160.20.10 23 318 6.9E-29 T 17-03-2017 IPR012334 Pectin lyase fold SHXM_RS32495 f6c9c71b899dfa447017dc7ec9f7a146 351 SUPERFAMILY SSF51126 32 316 4.89E-17 T 17-03-2017 IPR011050 Pectin lyase fold/virulence factor SHXM_RS35295 cd1a2a60fdcef0373673b1efd06cd33c 251 Pfam PF01061 ABC-2 type transporter 12 215 1.8E-27 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS35295 cd1a2a60fdcef0373673b1efd06cd33c 251 PIRSF PIRSF006648 3 251 3.3E-44 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS38820 8091d58b167a929989f49d1516aec415 165 Gene3D G3DSA:3.90.550.10 25 95 2.2E-7 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS38820 8091d58b167a929989f49d1516aec415 165 SUPERFAMILY SSF53448 9 119 4.22E-14 T 17-03-2017 IPR029044 Nucleotide-diphospho-sugar transferases SHXM_RS38820 8091d58b167a929989f49d1516aec415 165 Pfam PF13632 Glycosyl transferase family group 2 15 119 4.1E-7 T 17-03-2017 IPR001173 Glycosyltransferase 2-like Reactome: R-HSA-913709 SHXM_RS17615 2fc08095efeab6445e555894ebefe8d4 420 Pfam PF07730 Histidine kinase 219 283 1.7E-18 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS17615 2fc08095efeab6445e555894ebefe8d4 420 SUPERFAMILY SSF55874 302 416 4.4E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS01800 753c8fd35e059c96ba6817c0ad735dff 307 Pfam PF14100 Methane oxygenase PmoA 15 301 4.6E-76 T 17-03-2017 IPR029475 Methane oxygenase PmoA SHXM_RS34715 36aadac242ac5300286bc9bef0dd51a5 169 SUPERFAMILY SSF50475 25 151 1.18E-26 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS34715 36aadac242ac5300286bc9bef0dd51a5 169 Gene3D G3DSA:2.30.110.10 22 169 5.7E-45 T 17-03-2017 IPR012349 FMN-binding split barrel GO:0010181|GO:0016491|GO:0055114 SHXM_RS34715 36aadac242ac5300286bc9bef0dd51a5 169 Pfam PF01243 Pyridoxamine 5'-phosphate oxidase 28 110 4.8E-15 T 17-03-2017 IPR011576 Pyridoxamine 5'-phosphate oxidase-like, FMN-binding domain GO:0004733|GO:0010181|GO:0055114 KEGG: 00750+1.4.3.5|MetaCyc: PWY-7204|MetaCyc: PWY-7282|Reactome: R-HSA-964975 SHXM_RS24280 cbbb562450fb6c93935fbc6da48718ad 189 Gene3D G3DSA:3.10.129.10 17 170 6.4E-55 T 17-03-2017 IPR029069 HotDog domain SHXM_RS24280 cbbb562450fb6c93935fbc6da48718ad 189 SUPERFAMILY SSF54637 17 171 1.14E-44 T 17-03-2017 IPR029069 HotDog domain SHXM_RS24280 cbbb562450fb6c93935fbc6da48718ad 189 Pfam PF03061 Thioesterase superfamily 37 107 1.5E-19 T 17-03-2017 IPR006683 Thioesterase domain Reactome: R-HSA-75105 SHXM_RS48935 0e6236710607ee9bceb76aee1d62c4a0 153 Pfam PF13586 Transposase DDE domain 55 149 1.1E-22 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS38600 bdd6bf99694821fd9ba28e56dd92a755 357 Pfam PF01066 CDP-alcohol phosphatidyltransferase 46 112 1.0E-10 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS38600 bdd6bf99694821fd9ba28e56dd92a755 357 ProSitePatterns PS00379 CDP-alcohol phosphatidyltransferases signature. 90 112 - T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS15490 663739967d81ce39a3f9911ec50dbd45 283 SUPERFAMILY SSF53613 23 274 7.48E-58 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS15490 663739967d81ce39a3f9911ec50dbd45 283 Pfam PF08543 Phosphomethylpyrimidine kinase 33 274 1.0E-59 T 17-03-2017 IPR013749 Pyridoxamine kinase/Phosphomethylpyrimidine kinase Reactome: R-HSA-964975 SHXM_RS15490 663739967d81ce39a3f9911ec50dbd45 283 TIGRFAM TIGR00097 HMP-P_kinase: hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase 27 275 1.2E-63 T 17-03-2017 IPR004399 Hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase GO:0008972|GO:0009228 KEGG: 00730+2.7.1.49|MetaCyc: PWY-6910|MetaCyc: PWY-7356|MetaCyc: PWY-7357 SHXM_RS15490 663739967d81ce39a3f9911ec50dbd45 283 Gene3D G3DSA:3.40.1190.20 25 275 5.1E-67 T 17-03-2017 IPR029056 Ribokinase-like SHXM_RS32000 34d3cf922667f273d9ae6783796eb57a 318 TIGRFAM TIGR02778 ligD_pol: DNA ligase D, polymerase domain 12 256 1.0E-76 T 17-03-2017 IPR014145 DNA ligase D, polymerase domain SHXM_RS02280 fc6697e55f8aa18e0b837217e122dca1 137 Gene3D G3DSA:3.10.180.10 2 132 1.3E-20 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS02280 fc6697e55f8aa18e0b837217e122dca1 137 Pfam PF13669 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 6 105 7.2E-13 T 17-03-2017 SHXM_RS02280 fc6697e55f8aa18e0b837217e122dca1 137 SUPERFAMILY SSF54593 2 120 6.07E-18 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS29460 ddec027b3de096f692faaa5d66b5bb8e 363 Pfam PF06626 Protein of unknown function (DUF1152) 4 289 2.1E-86 T 17-03-2017 IPR010581 Protein of unknown function DUF1152 SHXM_RS09720 61c6d1af0cc611bfb2a443f26940f8ca 177 Pfam PF13359 DDE superfamily endonuclease 19 163 1.7E-22 T 17-03-2017 IPR027806 Harbinger transposase-derived nuclease domain SHXM_RS22930 9a1b9aa3e668d6294e2b569212c88028 421 TIGRFAM TIGR03296 M6dom_TIGR03296: M6 family metalloprotease domain 79 348 1.4E-52 T 17-03-2017 IPR008757 Peptidase M6-like, domain GO:0006508|GO:0008233 SHXM_RS22930 9a1b9aa3e668d6294e2b569212c88028 421 Gene3D G3DSA:3.40.390.10 216 263 4.9E-5 T 17-03-2017 IPR024079 Metallopeptidase, catalytic domain GO:0008237 SHXM_RS06960 3ba8c515411ec58a23736e01a6676112 233 Pfam PF07335 Fungal chitosanase of glycosyl hydrolase group 75 87 216 5.0E-27 T 17-03-2017 IPR009939 Fungal chitosanase KEGG: 00520+3.2.1.132 SHXM_RS03675 98a16707175205f6b022c18c18091933 517 Pfam PF03611 PTS system sugar-specific permease component 14 427 1.2E-129 T 17-03-2017 IPR004703 Phosphotransferase system, sugar-specific permease component GO:0009401|GO:0016021 SHXM_RS50400 d94564fe5f257f9b71e40b4974b6c621 60 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 11 60 5.0E-13 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS09030 7caa8eae99d09c8b7e4b64fac711ab4d 167 Gene3D G3DSA:2.30.320.10 101 161 1.5E-5 T 17-03-2017 IPR015315 Protein of unknown function DUF1963 SHXM_RS18850 d20c89e1173ff5a931a2ae81e946bedc 238 Pfam PF01694 Rhomboid family 76 226 1.6E-38 T 17-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SHXM_RS18850 d20c89e1173ff5a931a2ae81e946bedc 238 Gene3D G3DSA:1.20.1540.10 18 222 2.7E-39 T 17-03-2017 IPR022764 Peptidase S54, rhomboid domain GO:0004252|GO:0016021 SHXM_RS18850 d20c89e1173ff5a931a2ae81e946bedc 238 SUPERFAMILY SSF144091 18 226 2.35E-38 T 17-03-2017 SHXM_RS15470 20357429ef60edc4f4d87f632ba3d349 465 Pfam PF14907 Uncharacterised nucleotidyltransferase 42 189 4.5E-14 T 17-03-2017 SHXM_RS28670 5ca0476fd570b1d70a15d8ba5a4d5581 222 Pfam PF11303 Protein of unknown function (DUF3105) 92 214 1.7E-43 T 17-03-2017 IPR021454 Protein of unknown function DUF3105 SHXM_RS22955 59bc1c7d067e5778c8abea8251413d1e 415 Pfam PF09375 Imelysin 176 402 3.1E-18 T 17-03-2017 SHXM_RS42185 45607663a6924224f71942938b843c87 320 Gene3D G3DSA:3.40.50.720 145 269 5.2E-10 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS42185 45607663a6924224f71942938b843c87 320 Gene3D G3DSA:3.40.192.10 12 144 1.0E-5 T 17-03-2017 SHXM_RS42185 45607663a6924224f71942938b843c87 320 SUPERFAMILY SSF51735 138 278 2.95E-7 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS18300 6e0487ae53a587eed4afbd63877168fd 275 Pfam PF13462 Thioredoxin 102 269 1.2E-25 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18300 6e0487ae53a587eed4afbd63877168fd 275 Gene3D G3DSA:3.40.30.10 100 269 7.3E-27 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS18300 6e0487ae53a587eed4afbd63877168fd 275 SUPERFAMILY SSF52833 99 255 2.0E-24 T 17-03-2017 IPR012336 Thioredoxin-like fold SHXM_RS27180 77655f746471e6b237111cff650047b4 213 Pfam PF01066 CDP-alcohol phosphatidyltransferase 28 95 3.8E-9 T 17-03-2017 IPR000462 CDP-alcohol phosphatidyltransferase GO:0008654|GO:0016020|GO:0016780 SHXM_RS33745 c3cbf0b3d2eecc1bafb993d699cba340 130 SUPERFAMILY SSF88723 4 126 1.5E-8 T 17-03-2017 IPR029060 PIN domain-like SHXM_RS35830 f1323f63db1aa4d5aa8711d6d7b06c4d 252 Pfam PF07302 AroM protein 21 248 3.4E-73 T 17-03-2017 IPR010843 Uncharacterised protein family AroM SHXM_RS35830 f1323f63db1aa4d5aa8711d6d7b06c4d 252 ProDom PD037589 AROM ARO OPERON REGULATED BY AROR BIOSYNTHESIS TRANSCRIPTION AMINO AROMATIC 20 247 9.0E-29 T 17-03-2017 IPR010843 Uncharacterised protein family AroM SHXM_RS45555 d06ec5341c4fc49741b32bdd3dde995d 309 SUPERFAMILY SSF161098 88 291 2.88E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45555 d06ec5341c4fc49741b32bdd3dde995d 309 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 113 305 1.0E-35 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS45555 d06ec5341c4fc49741b32bdd3dde995d 309 Gene3D G3DSA:1.10.3720.10 89 295 5.9E-15 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS17070 d0fd8a52c49f8ace992bc6eaf5cf9780 526 Pfam PF02616 Segregation and condensation protein ScpA 250 470 1.4E-48 T 17-03-2017 IPR003768 Segregation and condensation protein A SHXM_RS34455 56965184fa669ac8d3c40cc78ccbb07f 212 Gene3D G3DSA:3.40.50.1820 24 192 2.8E-17 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS34455 56965184fa669ac8d3c40cc78ccbb07f 212 SUPERFAMILY SSF53474 2 207 3.63E-18 T 17-03-2017 IPR029058 Alpha/Beta hydrolase fold SHXM_RS18600 654d66f9cf94ce7513eee073be40f8e3 194 Pfam PF04977 Septum formation initiator 52 94 3.7E-7 T 17-03-2017 IPR007060 Septum formation initiator FtsL/DivIC GO:0007049 SHXM_RS40360 2c7060037d3cb7d750b0e97b0fc90634 49 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 7 41 1.7E-11 T 17-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 SHXM_RS21095 e21c5f1776f352c7d6faf86c217eb62f 68 Pfam PF04149 Domain of unknown function (DUF397) 6 59 4.4E-16 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS12615 4c411de9f9b538163b8c5bb556939e82 192 Pfam PF14280 Domain of unknown function (DUF4365) 38 185 2.2E-23 T 17-03-2017 IPR025375 Domain of unknown function DUF4365 SHXM_RS03685 998a1bb48b7183b4c1c9fd8e29cbe132 402 Gene3D G3DSA:1.20.1250.20 212 389 1.7E-10 T 17-03-2017 SHXM_RS03685 998a1bb48b7183b4c1c9fd8e29cbe132 402 Gene3D G3DSA:1.20.1250.20 38 188 6.6E-9 T 17-03-2017 SHXM_RS03685 998a1bb48b7183b4c1c9fd8e29cbe132 402 Pfam PF07690 Major Facilitator Superfamily 15 265 2.3E-14 T 17-03-2017 IPR011701 Major facilitator superfamily GO:0016021|GO:0055085 SHXM_RS03685 998a1bb48b7183b4c1c9fd8e29cbe132 402 SUPERFAMILY SSF103473 16 387 2.49E-27 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS24285 121b921e7d1d9c614cf772e13365d162 410 TIGRFAM TIGR00350 lytR_cpsA_psr: cell envelope-related function transcriptional attenuator common domain 164 317 4.9E-42 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS24285 121b921e7d1d9c614cf772e13365d162 410 Pfam PF03816 Cell envelope-related transcriptional attenuator domain 164 317 2.4E-47 T 17-03-2017 IPR004474 Cell envelope-related transcriptional attenuator domain SHXM_RS48025 36a053ef93c39eb0b5885d9b9560fe3b 134 Pfam PF01408 Oxidoreductase family, NAD-binding Rossmann fold 9 122 9.7E-16 T 17-03-2017 IPR000683 Oxidoreductase, N-terminal GO:0016491 SHXM_RS48025 36a053ef93c39eb0b5885d9b9560fe3b 134 SUPERFAMILY SSF51735 5 121 2.85E-25 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS48025 36a053ef93c39eb0b5885d9b9560fe3b 134 Gene3D G3DSA:3.40.50.720 6 122 1.8E-22 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS12480 8214e6d6b5593bc0a747cd482e5eec55 286 Pfam PF01061 ABC-2 type transporter 36 240 2.0E-24 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS12480 8214e6d6b5593bc0a747cd482e5eec55 286 PIRSF PIRSF006648 2 285 1.3E-28 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS45860 c09b3848a4ec183af7eabfb4c613a612 524 Pfam PF03806 AbgT putative transporter family 25 521 3.2E-148 T 17-03-2017 IPR004697 p-aminobenzoyl-glutamate transport protein AbgT GO:0015558|GO:1902604 SHXM_RS37570 0c784b286e5f9af7ed5b407c45d6bc35 360 Pfam PF11268 Protein of unknown function (DUF3071) 12 179 5.7E-55 T 17-03-2017 IPR021421 Protein of unknown function DUF3071 SHXM_RS49405 d842f7591c0ed59954aaa7b3d732c6c6 295 Pfam PF05378 Hydantoinase/oxoprolinase N-terminal region 5 185 2.2E-43 T 17-03-2017 IPR008040 Hydantoinaseoxoprolinase, N-terminal Reactome: R-HSA-174403|Reactome: R-HSA-5578998 SHXM_RS44555 d2e8c7acc382206f7d1012d6eb7ab8a1 197 Pfam PF09250 Bifunctional DNA primase/polymerase, N-terminal 36 179 3.7E-5 T 17-03-2017 IPR015330 DNA primase/polymerase, bifunctional, N-terminal SHXM_RS05530 d24e191370a00a6eafeaaafca1c1c480 157 Pfam PF07080 Protein of unknown function (DUF1348) 6 147 7.4E-75 T 17-03-2017 IPR009783 Protein of unknown function DUF1348 SHXM_RS05530 d24e191370a00a6eafeaaafca1c1c480 157 Gene3D G3DSA:3.10.450.50 13 156 2.1E-78 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS05530 d24e191370a00a6eafeaaafca1c1c480 157 SUPERFAMILY SSF54427 5 157 9.23E-83 T 17-03-2017 IPR032710 NTF2-like domain SHXM_RS43310 4666125c8db0f36f3adf2e05002fbf18 152 SUPERFAMILY SSF55874 45 136 6.94E-10 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43310 4666125c8db0f36f3adf2e05002fbf18 152 Gene3D G3DSA:3.30.565.10 42 136 9.4E-8 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS43310 4666125c8db0f36f3adf2e05002fbf18 152 Pfam PF13581 Histidine kinase-like ATPase domain 36 148 1.1E-14 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS26920 36875d1a1d1ed8af501b9a79797fbb90 308 Pfam PF00482 Type II secretion system (T2SS), protein F 136 253 2.6E-9 T 17-03-2017 IPR018076 Type II secretion system F domain SHXM_RS38605 971ca228dac0159227f2bad7056c7b15 310 TIGRFAM TIGR04267 mod_HExxH: HEXXH motif domain 131 297 2.5E-17 T 17-03-2017 IPR026337 HEXXH motif domain SHXM_RS09755 9d8aab0dadfceed820c30a2dfc04be18 214 Pfam PF01810 LysE type translocator 16 209 5.8E-30 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS09755 9d8aab0dadfceed820c30a2dfc04be18 214 PIRSF PIRSF006324 2 212 4.5E-54 T 17-03-2017 IPR001123 Lysine-type exporter protein (LYSE/YGGA) GO:0006865|GO:0016020 SHXM_RS35010 fe35d28e84109f739c4a844f7880e897 802 Pfam PF07693 KAP family P-loop domain 203 285 3.8E-6 T 17-03-2017 IPR011646 KAP family P-loop domain SHXM_RS35010 fe35d28e84109f739c4a844f7880e897 802 Pfam PF07693 KAP family P-loop domain 488 686 4.3E-16 T 17-03-2017 IPR011646 KAP family P-loop domain SHXM_RS30030 2fed4dc5b2e44e60fff2d410231448ff 247 PIRSF PIRSF006648 1 247 5.6E-62 T 17-03-2017 IPR000412 ABC-2 transporter GO:0006810|GO:0016020 SHXM_RS30030 2fed4dc5b2e44e60fff2d410231448ff 247 Pfam PF01061 ABC-2 type transporter 6 211 3.2E-23 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS25540 cbc87e9f1261414faea40de2fbd16a8c 114 Pfam PF08239 Bacterial SH3 domain 50 113 4.0E-8 T 17-03-2017 IPR003646 SH3-like domain, bacterial-type SHXM_RS25880 a1672fb615b869450687d4d3daf82181 72 Pfam PF11662 Protein of unknown function (DUF3263) 1 72 1.4E-33 T 17-03-2017 IPR021678 Protein of unknown function DUF3263 SHXM_RS08670 b362245f6be96d633ba0ab208838dff0 560 Pfam PF05960 Bacterial protein of unknown function (DUF885) 26 556 5.1E-148 T 17-03-2017 IPR010281 Protein of unknown function DUF885 SHXM_RS20885 d9e4e7485bbcdd39ec76cb91e9b0e8cf 129 Pfam PF13586 Transposase DDE domain 30 108 1.4E-10 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS03390 30fad8fbf6b9fa84b54fece307469cd6 290 SUPERFAMILY SSF103481 50 126 3.14E-6 T 17-03-2017 SHXM_RS04665 17a65139d0600d142ba1d901b42863bd 184 Pfam PF07681 DoxX 8 91 1.8E-14 T 17-03-2017 IPR032808 DoxX family SHXM_RS01220 36c52a4f757aa632af7c8569ef17f21c 152 Pfam PF01526 Tn3 transposase DDE domain 1 130 7.8E-39 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS28480 f5c852b89af1a252157a6b33adeb61a8 234 Pfam PF14016 Protein of unknown function (DUF4232) 103 225 1.9E-21 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS32860 9f861efeb8eb1835a04ce7b087a793ee 856 Pfam PF12704 MacB-like periplasmic core domain 19 233 1.1E-14 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS32860 9f861efeb8eb1835a04ce7b087a793ee 856 Pfam PF12704 MacB-like periplasmic core domain 496 697 1.8E-7 T 17-03-2017 IPR025857 MacB-like periplasmic core domain SHXM_RS32860 9f861efeb8eb1835a04ce7b087a793ee 856 Pfam PF02687 FtsX-like permease family 271 391 1.5E-24 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS32860 9f861efeb8eb1835a04ce7b087a793ee 856 Pfam PF02687 FtsX-like permease family 733 848 5.1E-20 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS36470 daa10f0f30bc722588275686316a24e4 309 Gene3D G3DSA:3.40.33.10 185 300 1.6E-11 T 17-03-2017 IPR014044 CAP domain SHXM_RS36470 daa10f0f30bc722588275686316a24e4 309 Pfam PF00188 Cysteine-rich secretory protein family 193 307 7.5E-20 T 17-03-2017 IPR014044 CAP domain SHXM_RS36470 daa10f0f30bc722588275686316a24e4 309 SUPERFAMILY SSF55797 188 308 4.19E-22 T 17-03-2017 IPR014044 CAP domain SHXM_RS08330 42173b47b9701495e5f271bf83c23657 290 Pfam PF13460 NAD(P)H-binding 10 182 4.4E-12 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08330 42173b47b9701495e5f271bf83c23657 290 SUPERFAMILY SSF51735 4 280 1.65E-42 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS08330 42173b47b9701495e5f271bf83c23657 290 Gene3D G3DSA:3.40.50.720 3 216 1.6E-26 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS41150 5e69f09c3c5866948b3d3b99bf35e574 151 Pfam PF08592 Domain of unknown function (DUF1772) 18 146 2.6E-15 T 17-03-2017 IPR013901 Protein of unknown function DUF1772 SHXM_RS11320 9c2d88592b265f02deaafff7948cdae5 74 Pfam PF04149 Domain of unknown function (DUF397) 14 68 1.9E-20 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS09365 0b5be90364a2781848e26bdd2ae39d37 56 Pfam PF13592 Winged helix-turn helix 1 30 6.8E-10 T 17-03-2017 IPR025959 Winged helix-turn helix domain SHXM_RS49975 e722644a69c0a93c3232f1e50cdf3eec 43 Pfam PF13551 Winged helix-turn helix 2 39 3.1E-9 T 17-03-2017 SHXM_RS03635 4ade7077092c002a316b3af58eaaa14f 218 ProDom PD068376 ORF2 SECRETED GLNII PRECURSOR SIGNAL 34 218 3.0E-48 T 17-03-2017 SHXM_RS03200 4d5af794ecf54d1e9bde876e15160584 311 Pfam PF03706 Lysylphosphatidylglycerol synthase TM region 13 298 6.6E-30 T 17-03-2017 IPR022791 Lysylphosphatidylglycerol synthetase/glycosyltransferase AglD SHXM_RS18045 b39162f407635c946a720d977722b152 407 Pfam PF06081 Aromatic acid exporter family member 1 22 157 9.2E-10 T 17-03-2017 IPR010343 Aromatic acid exporter family member 1 SHXM_RS35090 4ae53156382d210ead040d3934a9792d 224 Pfam PF09517 Eco29kI restriction endonuclease 40 178 5.7E-50 T 17-03-2017 IPR018575 Restriction endonuclease, type II, Eco29kI SHXM_RS38065 f54397a4bd619692d7d44e8696197297 44 Gene3D G3DSA:1.10.357.10 2 42 6.2E-6 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS38065 f54397a4bd619692d7d44e8696197297 44 SUPERFAMILY SSF48498 2 42 8.01E-6 T 17-03-2017 IPR011075 Tetracycline transcriptional regulator, TetR-related, C-terminal SHXM_RS17645 78b53ca2e2afadbf73cc39bb855f7206 290 Pfam PF14100 Methane oxygenase PmoA 22 280 1.1E-57 T 17-03-2017 IPR029475 Methane oxygenase PmoA SHXM_RS32305 bcdcaa769e678dcc0fa362ac5d828d1b 92 Pfam PF13828 Domain of unknown function (DUF4190) 21 79 1.1E-9 T 17-03-2017 IPR025241 Domain of unknown function DUF4190 SHXM_RS01735 de33435f62acd9b6faf7c4c7ec4b105c 265 SUPERFAMILY SSF56281 2 256 9.57E-31 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01735 de33435f62acd9b6faf7c4c7ec4b105c 265 Pfam PF00753 Metallo-beta-lactamase superfamily 19 251 1.2E-15 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01735 de33435f62acd9b6faf7c4c7ec4b105c 265 SMART SM00849 20 251 1.2E-17 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS01735 de33435f62acd9b6faf7c4c7ec4b105c 265 Gene3D G3DSA:3.60.15.10 2 258 2.4E-35 T 17-03-2017 IPR001279 Metallo-beta-lactamase SHXM_RS45900 97a473cb5c22dae0e8eccb1f794d53f9 277 Pfam PF03988 Repeat of Unknown Function (DUF347) 210 264 4.4E-17 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS45900 97a473cb5c22dae0e8eccb1f794d53f9 277 Pfam PF03988 Repeat of Unknown Function (DUF347) 34 84 5.4E-16 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS45900 97a473cb5c22dae0e8eccb1f794d53f9 277 Pfam PF03988 Repeat of Unknown Function (DUF347) 154 200 4.4E-11 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS45900 97a473cb5c22dae0e8eccb1f794d53f9 277 Pfam PF03988 Repeat of Unknown Function (DUF347) 89 140 7.4E-13 T 17-03-2017 IPR007136 Protein of unknown function DUF347 SHXM_RS17995 4cf74237397deeab5ef0cd3de5cd5b90 665 Gene3D G3DSA:2.60.60.30 65 161 4.9E-15 T 17-03-2017 SHXM_RS17995 4cf74237397deeab5ef0cd3de5cd5b90 665 Pfam PF02342 TerD domain 64 162 1.1E-15 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS43800 c34e9a844688b6a6295a917bb0bcc891 131 Pfam PF05331 Protein of unknown function (DUF742) 15 131 6.0E-36 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS27840 cf2284b444dc901e84b010b25fe64546 475 Pfam PF07907 YibE/F-like protein 195 432 7.9E-71 T 17-03-2017 IPR012507 YibE/F-like SHXM_RS26250 8b0954c7b2c01d07d65f34a885e3fae6 86 Pfam PF04149 Domain of unknown function (DUF397) 5 22 1.2E-6 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS26250 8b0954c7b2c01d07d65f34a885e3fae6 86 Pfam PF04149 Domain of unknown function (DUF397) 24 74 2.4E-14 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS28860 7b7ffe2a676abfa0583451ea03b97e34 118 ProDom PD072590 AQ_1176 9 111 7.0E-8 T 17-03-2017 SHXM_RS27490 974ba690ef015619737e583b1527d238 307 Gene3D G3DSA:3.40.1350.10 167 273 8.1E-4 T 17-03-2017 IPR011856 tRNA endonuclease-like domain GO:0003676|GO:0004518 Reactome: R-HSA-6784531 SHXM_RS27490 974ba690ef015619737e583b1527d238 307 SUPERFAMILY SSF52980 167 274 1.66E-5 T 17-03-2017 IPR011335 Restriction endonuclease type II-like Reactome: R-HSA-6783310 SHXM_RS17855 2502b7ab24da6d778ab265f2acde1421 349 Gene3D G3DSA:3.20.20.140 4 344 1.2E-69 T 17-03-2017 SHXM_RS24355 8ca72640690e5683d2708b6d94b89130 251 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 213 249 6.6E-5 T 17-03-2017 IPR019931 LPXTG cell wall anchor domain SHXM_RS30880 3cacd733fffe3533a0666579c99ac5b7 316 Gene3D G3DSA:3.40.630.10 40 313 3.8E-79 T 17-03-2017 SHXM_RS30880 3cacd733fffe3533a0666579c99ac5b7 316 SUPERFAMILY SSF53187 48 313 7.43E-73 T 17-03-2017 SHXM_RS30880 3cacd733fffe3533a0666579c99ac5b7 316 Pfam PF04389 Peptidase family M28 104 309 1.2E-48 T 17-03-2017 IPR007484 Peptidase M28 SHXM_RS39415 f8367540f40ec276c6468f60333f14b7 365 Gene3D G3DSA:3.20.20.70 2 362 1.8E-102 T 17-03-2017 IPR013785 Aldolase-type TIM barrel GO:0003824 SHXM_RS39415 f8367540f40ec276c6468f60333f14b7 365 SUPERFAMILY SSF51395 1 362 2.28E-97 T 17-03-2017 SHXM_RS39415 f8367540f40ec276c6468f60333f14b7 365 Pfam PF00724 NADH:flavin oxidoreductase / NADH oxidase family 5 337 2.6E-69 T 17-03-2017 IPR001155 NADH:flavin oxidoreductase/NADH oxidase, N-terminal GO:0010181|GO:0016491|GO:0055114 SHXM_RS14640 8044c68e330bb6766eb8ce627b3d59a2 117 Gene3D G3DSA:3.10.180.10 5 109 8.7E-14 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS14640 8044c68e330bb6766eb8ce627b3d59a2 117 SUPERFAMILY SSF54593 9 112 1.2E-12 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS33110 c586a2fbbcbb8d6dd3800d319dfcc1d4 148 Gene3D G3DSA:1.10.357.10 3 144 2.9E-5 T 17-03-2017 IPR015893 Tetracycline transcriptional regulator, TetR-like, C-terminal GO:0003677 SHXM_RS48295 401f22fb644ebdd113cbe2482b6c9092 418 Pfam PF03824 High-affinity nickel-transport protein 179 302 6.9E-9 T 17-03-2017 IPR011541 Nickel/cobalt transporter, high-affinity GO:0015099|GO:0016021|GO:0035444|GO:0046872 SHXM_RS03190 dbb28093ef22d26aecbf6278e372ad1e 462 Pfam PF09594 Protein of unknown function (DUF2029) 152 366 6.1E-6 T 17-03-2017 IPR018584 Glycosyltransferase family 87 GO:0016758 SHXM_RS05880 46cf618f697312cd721a6d39d9a14f48 343 Pfam PF07070 SpoOM protein 3 217 2.1E-77 T 17-03-2017 IPR009776 Sporulation stage 0, protein M SHXM_RS24765 6ec5b178ecec37789ccd8411530a6956 341 Gene3D G3DSA:3.20.20.140 1 335 2.5E-84 T 17-03-2017 SHXM_RS24765 6ec5b178ecec37789ccd8411530a6956 341 Pfam PF04909 Amidohydrolase 3 330 2.1E-51 T 17-03-2017 IPR006680 Amidohydrolase-related GO:0016787 SHXM_RS24765 6ec5b178ecec37789ccd8411530a6956 341 SUPERFAMILY SSF51556 1 331 1.81E-88 T 17-03-2017 IPR032466 Metal-dependent hydrolase SHXM_RS08315 9822434b6b2986139a413df53ec30ff4 284 Gene3D G3DSA:3.40.50.1460 5 269 1.1E-53 T 17-03-2017 IPR029030 Caspase-like domain SHXM_RS08315 9822434b6b2986139a413df53ec30ff4 284 Pfam PF00656 Caspase domain 18 267 1.2E-24 T 17-03-2017 SHXM_RS09905 cb6f5fd413e4b7e1ea70947d52f947ec 177 Pfam PF13586 Transposase DDE domain 84 165 2.4E-20 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS50640 5df964172d9c5d89de6357bab10e1b7e 67 Pfam PF01526 Tn3 transposase DDE domain 1 41 1.5E-5 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS23945 da7c8956a8d3df4c8dd393e2c1049baa 299 Gene3D G3DSA:1.10.10.10 58 100 6.9E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS23945 da7c8956a8d3df4c8dd393e2c1049baa 299 SUPERFAMILY SSF46785 58 100 9.41E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS47030 dfcad59b0d09811989345a6f879f73d8 402 SUPERFAMILY SSF55874 278 390 5.46E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS47030 dfcad59b0d09811989345a6f879f73d8 402 Pfam PF07730 Histidine kinase 186 259 3.3E-12 T 17-03-2017 IPR011712 Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain GO:0000155|GO:0000160|GO:0016021|GO:0046983 SHXM_RS47190 0226783b063e67e1307d1343f37bc042 148 Pfam PF08592 Domain of unknown function (DUF1772) 18 146 2.5E-17 T 17-03-2017 IPR013901 Protein of unknown function DUF1772 SHXM_RS18630 5b05431631b2085dc82bac951adbe05a 130 Pfam PF11239 Protein of unknown function (DUF3040) 1 80 6.5E-29 T 17-03-2017 IPR021401 Protein of unknown function DUF3040 SHXM_RS26770 7ea11bc81fe3d677c58826b993454887 286 Pfam PF10935 Protein of unknown function (DUF2637) 18 156 5.9E-12 T 17-03-2017 IPR021235 Protein of unknown function DUF2637 SHXM_RS44795 05d9cd7d63913fcb1738f46c3a058096 65 SUPERFAMILY SSF54593 10 63 1.06E-12 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS44795 05d9cd7d63913fcb1738f46c3a058096 65 Gene3D G3DSA:3.10.180.10 13 63 1.1E-15 T 17-03-2017 IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase SHXM_RS21105 b29d05b9bcfd9ba459bd01c318532d55 139 SUPERFAMILY SSF55874 40 119 3.52E-7 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS21105 b29d05b9bcfd9ba459bd01c318532d55 139 Pfam PF13581 Histidine kinase-like ATPase domain 19 111 3.2E-9 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS24445 ae811e282ef4e985c80859005734e1fd 488 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 26 448 3.0E-57 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS24445 ae811e282ef4e985c80859005734e1fd 488 PIRSF PIRSF002744 3 471 2.1E-105 T 17-03-2017 IPR026030 Purine-cytosine permease Fcy2/21/22 GO:0005215|GO:0016021|GO:0055085 SHXM_RS01350 ec20edbc35a262d461851be498901a1e 235 Gene3D G3DSA:3.30.530.20 1 146 3.3E-32 T 17-03-2017 IPR023393 START-like domain SHXM_RS01350 ec20edbc35a262d461851be498901a1e 235 Pfam PF06240 Carbon monoxide dehydrogenase subunit G (CoxG) 7 142 6.5E-17 T 17-03-2017 IPR010419 Carbon monoxide dehydrogenase subunit G SHXM_RS01350 ec20edbc35a262d461851be498901a1e 235 SUPERFAMILY SSF55961 1 145 3.52E-28 T 17-03-2017 SHXM_RS09455 602653a418f4d2421c358c86013bd737 147 Pfam PF13701 Transposase DDE domain group 1 37 137 2.4E-16 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS43150 c96637062e2de003a522caf8ec5f16a1 210 Pfam PF11139 Sap, sulfolipid-1-addressing protein 5 208 5.2E-34 T 17-03-2017 IPR021315 Glycolipid exporter Gap/Sap SHXM_RS35030 c17b44eabfbcd3d5e2d736cf2bc6fc21 74 Pfam PF04149 Domain of unknown function (DUF397) 15 65 1.3E-18 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS12900 42c203819e696181a5fd29ed071c0617 162 SMART SM00900 84 159 2.7E-12 T 17-03-2017 IPR007329 FMN-binding GO:0010181|GO:0016020 SHXM_RS12900 42c203819e696181a5fd29ed071c0617 162 Pfam PF04205 FMN-binding domain 86 156 5.0E-9 T 17-03-2017 IPR007329 FMN-binding GO:0010181|GO:0016020 SHXM_RS39860 31d507409391c3d393d656f14187a0cb 322 Gene3D G3DSA:3.40.710.10 11 318 4.8E-66 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39860 31d507409391c3d393d656f14187a0cb 322 SUPERFAMILY SSF56601 10 279 3.5E-62 T 17-03-2017 IPR012338 Beta-lactamase/transpeptidase-like SHXM_RS39860 31d507409391c3d393d656f14187a0cb 322 Pfam PF00144 Beta-lactamase 12 280 4.1E-51 T 17-03-2017 IPR001466 Beta-lactamase-related SHXM_RS15160 46803e234174170dbcc729c9ea629518 152 Pfam PF13546 DDE superfamily endonuclease 25 121 1.5E-14 T 17-03-2017 SHXM_RS09990 9ee5e84e0034c74681cd9b37cd932d5e 139 Pfam PF14435 SUKH-4 immunity protein 29 136 1.1E-9 T 17-03-2017 IPR025851 SUKH-4 immunity protein SHXM_RS27845 9b694dc72515211f287a66e4e5598ffd 145 Pfam PF04686 Streptomyces sporulation and cell division protein, SsgA 23 120 1.2E-32 T 17-03-2017 IPR006776 Sporulation-specific cell division protein SsgB GO:0051301 SHXM_RS36285 41df1e66b66311c1a003dc12249c8cec 136 Pfam PF05331 Protein of unknown function (DUF742) 24 136 3.3E-39 T 17-03-2017 IPR007995 Protein of unknown function DUF742 SHXM_RS47080 38bb32d5ef31220e574ffbb176df61bd 485 Pfam PF00474 Sodium:solute symporter family 37 412 1.5E-24 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS01330 42b47ffd7304a1e67c9f4cef323762d3 259 PIRSF PIRSF015736 1 250 2.3E-59 T 17-03-2017 IPR026286 Maleate isomerase/Arylmalonate decarboxylase SHXM_RS01330 42b47ffd7304a1e67c9f4cef323762d3 259 Pfam PF01177 Asp/Glu/Hydantoin racemase 6 227 7.3E-9 T 17-03-2017 IPR015942 Asp/Glu/hydantoin racemase GO:0006807|GO:0036361 KEGG: 00471+5.1.1.3|MetaCyc: PWY-6386|MetaCyc: PWY-6387 SHXM_RS01330 42b47ffd7304a1e67c9f4cef323762d3 259 Hamap MF_00943 Maleate isomerase [maiA]. 4 250 48.103 T 17-03-2017 IPR028615 Maleate isomerase GO:0050076 KEGG: 00650+5.2.1.1|KEGG: 00760+5.2.1.1|MetaCyc: PWY-5033|MetaCyc: PWY-6993|MetaCyc: PWY-7128|MetaCyc: PWY-722 SHXM_RS28200 441d5fe91d462f7ea55b6071c3288a09 240 ProDom PD190647 REGULATORY RESISTANCE TRANSCRIPTION TRANSCRIPTIONAL ANTIBIOTIC DNA-BINDING ACTIVATOR REGULATION ORF699 NOSIHEPTIDE 1 239 4.0E-52 T 17-03-2017 SHXM_RS07270 294c728899c7b5af49bbbe2fb7322813 481 Pfam PF06762 Lipase maturation factor 121 270 1.1E-59 T 17-03-2017 IPR009613 Lipase maturation factor Reactome: R-HSA-192456 SHXM_RS07270 294c728899c7b5af49bbbe2fb7322813 481 Pfam PF06762 Lipase maturation factor 291 472 5.0E-63 T 17-03-2017 IPR009613 Lipase maturation factor Reactome: R-HSA-192456 SHXM_RS17245 730e8dd7b24db6d23f956cc90a3bd6c4 79 Pfam PF03777 Small secreted domain (DUF320) 25 77 1.5E-23 T 17-03-2017 IPR005528 Domain of unknown function DUF320, Streptomyces species SHXM_RS17395 7a9794ff9fb7fce94f0973658efc1232 316 Pfam PF04116 Fatty acid hydroxylase superfamily 86 218 5.6E-27 T 17-03-2017 IPR006694 Fatty acid hydroxylase GO:0005506|GO:0006633|GO:0016491|GO:0055114 SHXM_RS44085 fa2ecaaf8c810b9c7a32e552cbfb92ae 260 Pfam PF05988 Bacterial protein of unknown function (DUF899) 15 212 4.0E-60 T 17-03-2017 IPR010296 Protein of unknown function DUF899, thioredoxin-like SHXM_RS49880 2162e0e0dbfcef3114b0158f1c391367 237 Pfam PF06299 Protein of unknown function (DUF1045) 68 226 1.4E-56 T 17-03-2017 IPR009389 Protein of unknown function DUF1045 KEGG: 00030+2.7.4.23|MetaCyc: PWY-5532 SHXM_RS49880 2162e0e0dbfcef3114b0158f1c391367 237 PIRSF PIRSF033328 3 237 8.6E-66 T 17-03-2017 IPR009389 Protein of unknown function DUF1045 KEGG: 00030+2.7.4.23|MetaCyc: PWY-5532 SHXM_RS23060 9971638670cdd9c2a86b352a409cde4e 153 SUPERFAMILY SSF54637 25 110 6.29E-15 T 17-03-2017 IPR029069 HotDog domain SHXM_RS23060 9971638670cdd9c2a86b352a409cde4e 153 Gene3D G3DSA:3.10.129.10 16 126 7.3E-16 T 17-03-2017 IPR029069 HotDog domain SHXM_RS09270 0b1f38bfd8f55bed4ccdd707782e7db7 73 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 1 62 2.4E-24 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS44695 064cec9302351625893d3ccdcd1503ee 228 Pfam PF01391 Collagen triple helix repeat (20 copies) 126 182 1.7E-6 T 17-03-2017 IPR008160 Collagen triple helix repeat SHXM_RS39845 36a9d96428c10792495c2c97d0ff3d60 149 Pfam PF04463 Protein of unknown function (DUF523) 4 143 4.5E-39 T 17-03-2017 IPR007553 Domain of unknown function DUF523 SHXM_RS47325 66620b939b2885f2d94f4fbd15fd7de3 221 Pfam PF14016 Protein of unknown function (DUF4232) 86 213 1.0E-22 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS30080 e06167c01fdca7529cf74546a07a8516 85 Pfam PF11298 Protein of unknown function (DUF3099) 3 59 4.4E-6 T 17-03-2017 IPR021449 Protein of unknown function DUF3099 SHXM_RS01545 0a1b2e4f71d1799ee385b12a9054e9d3 211 SUPERFAMILY SSF160631 14 145 5.89E-8 T 17-03-2017 SHXM_RS10445 408126ffe88c13858c1752267526a4d4 222 Pfam PF09335 SNARE associated Golgi protein 32 160 1.6E-20 T 17-03-2017 IPR032816 SNARE associated Golgi protein SHXM_RS24945 56bf844a4e42c4c543afa8b0819a8fef 453 SUPERFAMILY SSF53756 76 312 6.04E-9 T 17-03-2017 SHXM_RS47585 bc9d96df687100f5196c77666e9153be 325 Pfam PF00248 Aldo/keto reductase family 16 317 3.4E-71 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47585 bc9d96df687100f5196c77666e9153be 325 SUPERFAMILY SSF51430 1 318 3.01E-98 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS47585 bc9d96df687100f5196c77666e9153be 325 Gene3D G3DSA:3.20.20.100 9 319 9.4E-99 T 17-03-2017 IPR023210 NADP-dependent oxidoreductase domain SHXM_RS34150 3586c701b052055bc67941615e2c97db 333 SUPERFAMILY SSF103481 77 176 1.15E-8 T 17-03-2017 SHXM_RS34150 3586c701b052055bc67941615e2c97db 333 SUPERFAMILY SSF103481 232 327 6.93E-9 T 17-03-2017 SHXM_RS34150 3586c701b052055bc67941615e2c97db 333 Pfam PF00892 EamA-like transporter family 188 322 1.5E-6 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS34150 3586c701b052055bc67941615e2c97db 333 Pfam PF00892 EamA-like transporter family 48 175 2.3E-8 T 17-03-2017 IPR000620 EamA domain GO:0016020|GO:0016021 SHXM_RS15005 264887d0aa6028b6d0997cdf5bdedcd4 191 Pfam PF13358 DDE superfamily endonuclease 7 142 3.4E-17 T 17-03-2017 SHXM_RS10365 9e17833529f77433e8678918186d507a 152 SUPERFAMILY SSF53041 10 114 3.79E-5 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS10365 9e17833529f77433e8678918186d507a 152 Pfam PF00239 Resolvase, N terminal domain 14 104 8.3E-5 T 17-03-2017 IPR006119 Resolvase, N-terminal catalytic domain GO:0000150|GO:0003677|GO:0006310 SHXM_RS27270 944348654aba72c3e398f43814a92748 386 Pfam PF01757 Acyltransferase family 33 335 8.6E-23 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS18255 6b9bc81eb79c5ddb533ca4f275039483 493 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 84 237 9.2E-12 T 17-03-2017 SHXM_RS35480 3cde1df24edaa1d353e3ac6b5bef12e8 110 TIGRFAM TIGR03954 integ_memb_HG: integral membrane protein 9 92 4.7E-28 T 17-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane SHXM_RS35480 3cde1df24edaa1d353e3ac6b5bef12e8 110 Pfam PF12823 Domain of unknown function (DUF3817) 6 93 1.9E-27 T 17-03-2017 IPR023845 Domain of unknown function DUF3817, transmembrane SHXM_RS22350 4ba5cceb957639646db877206c4e5829 137 PRINTS PR01217 Proline rich extensin signature 40 61 2.4E-9 T 17-03-2017 SHXM_RS22350 4ba5cceb957639646db877206c4e5829 137 PRINTS PR01217 Proline rich extensin signature 78 95 2.4E-9 T 17-03-2017 SHXM_RS22350 4ba5cceb957639646db877206c4e5829 137 PRINTS PR01217 Proline rich extensin signature 61 77 2.4E-9 T 17-03-2017 SHXM_RS22350 4ba5cceb957639646db877206c4e5829 137 PRINTS PR01217 Proline rich extensin signature 96 121 2.4E-9 T 17-03-2017 SHXM_RS33290 da7bac0d4759af7cecba515cd93320a9 319 Gene3D G3DSA:1.10.3720.10 90 307 1.1E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33290 da7bac0d4759af7cecba515cd93320a9 319 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 114 312 2.3E-38 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS33290 da7bac0d4759af7cecba515cd93320a9 319 SUPERFAMILY SSF161098 90 295 2.35E-20 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS25340 21412dc6c028bd9d922c7f088d79690a 585 SUPERFAMILY SSF51261 453 577 1.41E-40 T 17-03-2017 IPR011055 Duplicated hybrid motif SHXM_RS25340 21412dc6c028bd9d922c7f088d79690a 585 Gene3D G3DSA:2.70.70.10 434 578 1.4E-41 T 17-03-2017 SHXM_RS25340 21412dc6c028bd9d922c7f088d79690a 585 Pfam PF01551 Peptidase family M23 480 573 1.1E-27 T 17-03-2017 IPR016047 Peptidase M23 SHXM_RS15530 5babdd12fce64ad35b775a83b8e9efd7 183 TIGRFAM TIGR03696 Rhs_assc_core: RHS repeat-associated core domain 6 47 3.6E-12 T 17-03-2017 IPR022385 Rhs repeat-associated core GO:0097264 SHXM_RS09095 1ed900b2420e24cfb3f04155ead39c02 94 Pfam PF13586 Transposase DDE domain 3 74 5.3E-19 T 17-03-2017 IPR025668 Transposase DDE domain SHXM_RS50725 00cdb6fd8e7dc3fd8a71c367ba1c8d1e 249 SUPERFAMILY SSF56059 8 156 6.19E-8 T 17-03-2017 SHXM_RS04965 d1a9644038b60c2d8c56c51bb5508a45 296 Pfam PF03707 Bacterial signalling protein N terminal repeat 56 114 4.6E-16 T 17-03-2017 IPR005330 MHYT domain SHXM_RS04965 d1a9644038b60c2d8c56c51bb5508a45 296 Pfam PF03707 Bacterial signalling protein N terminal repeat 182 221 9.0E-5 T 17-03-2017 IPR005330 MHYT domain SHXM_RS04965 d1a9644038b60c2d8c56c51bb5508a45 296 Pfam PF03707 Bacterial signalling protein N terminal repeat 120 173 2.4E-16 T 17-03-2017 IPR005330 MHYT domain SHXM_RS03175 1dd246c231e1dd8843d3b65d825978a6 648 Pfam PF13515 Fusaric acid resistance protein-like 356 485 3.5E-13 T 17-03-2017 SHXM_RS26220 9526300ccee399fea052bf6f056f8ef9 494 Pfam PF05235 CHAD domain 256 399 1.1E-8 T 17-03-2017 IPR007899 CHAD domain SHXM_RS26220 9526300ccee399fea052bf6f056f8ef9 494 Pfam PF05235 CHAD domain 10 89 3.9E-6 T 17-03-2017 IPR007899 CHAD domain SHXM_RS49135 e3f1a70a1547c49d039a506e97083391 138 Pfam PF13374 Tetratricopeptide repeat 55 96 3.2E-8 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS00070 4c59ab4bb684daeb3c37fa8c35a7330b 344 Pfam PF13814 Replication-relaxation 45 116 9.9E-8 T 17-03-2017 IPR025855 Plasmid replication-relaxation SHXM_RS23425 a25f8d4d47a9eb19a90579bbff35b3d7 203 Pfam PF09438 Domain of unknown function (DUF2017) 9 201 1.1E-59 T 17-03-2017 IPR018561 Domain of unknown function DUF2017 SHXM_RS31585 ff4d3657141527a61878a465b9265814 237 SUPERFAMILY SSF81995 7 73 2.88E-6 T 17-03-2017 SHXM_RS30950 6fabc39f37451d03e41ec3cdc96cad11 194 Pfam PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 35 177 2.3E-31 T 17-03-2017 IPR001457 NADH:ubiquinone/plastoquinone oxidoreductase, chain 6 GO:0008137|GO:0055114 Reactome: R-HSA-611105|Reactome: R-HSA-6799198 SHXM_RS26890 ef09703c7d1836366829cbb146753b1f 142 Pfam PF13581 Histidine kinase-like ATPase domain 8 133 6.7E-32 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS25435 29d3e297c4251a6db8a69a423c3e87ea 212 TIGRFAM TIGR01167 LPXTG_anchor: LPXTG cell wall anchor domain 174 209 2.0E-4 T 17-03-2017 IPR019931 LPXTG cell wall anchor domain SHXM_RS40925 a006ba003674829a9380f0e2c8743d40 500 Pfam PF00474 Sodium:solute symporter family 34 427 1.1E-15 T 17-03-2017 IPR001734 Sodium/solute symporter GO:0005215|GO:0006810|GO:0016020|GO:0055085 SHXM_RS34535 894608673f3dd053bd128e1ebfdcca1b 66 Pfam PF04149 Domain of unknown function (DUF397) 5 56 3.0E-11 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS43925 3d5e61c3981079db49bc17cbf18d325f 110 Pfam PF06947 Protein of unknown function (DUF1290) 21 108 1.3E-34 T 17-03-2017 IPR009709 Protein of unknown function DUF1290 SHXM_RS43925 3d5e61c3981079db49bc17cbf18d325f 110 PIRSF PIRSF018579 1 110 3.1E-46 T 17-03-2017 IPR009709 Protein of unknown function DUF1290 SHXM_RS28495 3be6aace0fbd9fda0566a9bdd2178fec 228 Pfam PF14021 Protein of unknown function (DUF4237) 135 225 1.6E-28 T 17-03-2017 IPR025331 Protein of unknown function DUF4237 SHXM_RS07430 58b48170d1181fb6e784286b7db046fe 99 Pfam PF04149 Domain of unknown function (DUF397) 24 71 1.3E-12 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS03520 2ba2ba7ef306280a251a6b93c46dbfd2 339 Gene3D G3DSA:1.10.3720.10 109 322 1.2E-12 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03520 2ba2ba7ef306280a251a6b93c46dbfd2 339 Pfam PF00528 Binding-protein-dependent transport system inner membrane component 134 332 9.9E-30 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS03520 2ba2ba7ef306280a251a6b93c46dbfd2 339 SUPERFAMILY SSF161098 111 317 1.57E-13 T 17-03-2017 IPR000515 ABC transporter type 1, transmembrane domain MetI-like GO:0006810|GO:0016020 SHXM_RS12200 cb165f896ab0df1c87c895b828956b78 101 SUPERFAMILY SSF51735 1 71 1.28E-5 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS11540 29eaa44a70ee4b1dfbec7637f22a7a64 266 Pfam PF04039 Domain related to MnhB subunit of Na+/H+ antiporter 106 226 6.7E-24 T 17-03-2017 IPR007182 Na+/H+ antiporter MnhB subunit-related protein SHXM_RS49300 36c6113bf276dc9fed1182fb6f2cd064 191 Pfam PF13358 DDE superfamily endonuclease 7 142 5.1E-20 T 17-03-2017 SHXM_RS03705 3702f7c4c18a82631a22fbcdc5cf946e 420 Pfam PF13556 PucR C-terminal helix-turn-helix domain 356 413 5.0E-19 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS23090 8b3e8d7bfa0df3fe32b60ec6397d6b42 108 SUPERFAMILY SSF75169 1 101 1.3E-9 T 17-03-2017 IPR027396 DsrEFH-like SHXM_RS15440 a25109f43049e7a1f1a39cee0dc648e3 203 SUPERFAMILY SSF52540 148 188 1.39E-6 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS15440 a25109f43049e7a1f1a39cee0dc648e3 203 Gene3D G3DSA:3.40.50.300 144 184 5.5E-7 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS24805 233699c03ff131a4cbff90a5ff8348a8 191 Pfam PF04892 VanZ like family 22 141 6.9E-11 T 17-03-2017 IPR006976 VanZ-like SHXM_RS19805 80472c39e83c026f89cd686798c2dc98 542 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 361 426 6.1E-9 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS49275 7d4c1bf3a5d03649fa16a2f437d79c8f 37 Pfam PF14490 Helix-hairpin-helix containing domain 2 36 1.8E-10 T 17-03-2017 IPR029493 RecD helicase-like helix-hairpin-helix domain SHXM_RS44850 525a9a7caa41c7e433fa903f9de9bb4c 78 Pfam PF04149 Domain of unknown function (DUF397) 17 69 9.2E-15 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS44575 7edfb163df6bc8c174795452525e93ae 463 Pfam PF05133 Phage portal protein, SPP1 Gp6-like 20 406 2.3E-16 T 17-03-2017 IPR021145 Portal protein, SPP1 Gp6-like SHXM_RS23195 4e149191fc81bc435ec93f86ab03e333 69 Pfam PF04149 Domain of unknown function (DUF397) 13 63 2.5E-15 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS48570 65324551fb75de4578dbed0e83acb78a 66 Gene3D G3DSA:3.90.1150.10 9 46 7.6E-8 T 17-03-2017 IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2 GO:0003824 SHXM_RS22045 8fa0da6606c42420466099489fdf2827 342 Pfam PF07070 SpoOM protein 3 217 1.6E-63 T 17-03-2017 IPR009776 Sporulation stage 0, protein M SHXM_RS25825 30f977a7e3f4dc3ef23a0b36e9494174 90 Pfam PF13223 Protein of unknown function (DUF4031) 3 77 4.1E-31 T 17-03-2017 IPR025109 Domain of unknown function DUF4031 SHXM_RS29065 a42d21e3c169125be1f83a7f9d5592eb 317 Pfam PF04893 Yip1 domain 152 308 1.8E-12 T 17-03-2017 IPR006977 Yip1 domain GO:0016020 SHXM_RS11085 7c8018f8939e79e168b305755874d0ed 443 Pfam PF06974 Protein of unknown function (DUF1298) 286 395 8.9E-8 T 17-03-2017 IPR009721 O-acyltransferase WSD1, C-terminal GO:0004144 KEGG: 00073+2.3.1.20|KEGG: 00561+2.3.1.20 SHXM_RS03870 e75161312407db43756f69d63a0d3aac 133 Pfam PF12401 Protein of unknown function (DUF2662) 4 115 9.0E-30 T 17-03-2017 IPR022128 Protein of unknown function DUF3662 SHXM_RS14465 1fba6ecf97667d061325b0277d0db786 219 SUPERFAMILY SSF49899 54 204 5.8E-7 T 17-03-2017 IPR013320 Concanavalin A-like lectin/glucanase domain SHXM_RS01045 6314e46a294710f6d66391d5c6bbea5a 336 Pfam PF02653 Branched-chain amino acid transport system / permease component 67 323 2.1E-43 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS19225 19ce460337f165e49d6186802f66b1bd 62 SUPERFAMILY SSF55874 5 52 6.32E-5 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS41330 6f6bf64517846a43833caa1a18e8928f 214 Gene3D G3DSA:3.50.30.40 27 184 3.4E-48 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS41330 6f6bf64517846a43833caa1a18e8928f 214 Pfam PF03737 Demethylmenaquinone methyltransferase 29 176 4.3E-40 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS41330 6f6bf64517846a43833caa1a18e8928f 214 SUPERFAMILY SSF89562 26 186 2.49E-44 T 17-03-2017 IPR005493 Ribonuclease E inhibitor RraA/RraA-like protein SHXM_RS25710 09fb1a6c4492a27daf78371c03424a61 301 Pfam PF11228 Protein of unknown function (DUF3027) 31 256 1.7E-81 T 17-03-2017 IPR021391 Protein of unknown function DUF3027 SHXM_RS26605 309b7c29f913cb9a8c93cccff14eec4e 169 Pfam PF04138 GtrA-like protein 51 164 1.2E-25 T 17-03-2017 IPR007267 GtrA-like protein GO:0000271|GO:0006810|GO:0016021 SHXM_RS39310 e1e66a69c80e074789193c5f5937843f 190 SUPERFAMILY SSF46689 75 151 8.96E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS39310 e1e66a69c80e074789193c5f5937843f 190 Pfam PF13276 HTH-like domain 106 156 2.3E-7 T 17-03-2017 IPR025948 HTH-like domain SHXM_RS01455 a390f97e6a82668ac00512a606d7b506 407 Gene3D G3DSA:3.50.50.60 261 310 4.1E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01455 a390f97e6a82668ac00512a606d7b506 407 Gene3D G3DSA:3.50.50.60 13 177 4.1E-13 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01455 a390f97e6a82668ac00512a606d7b506 407 Pfam PF05834 Lycopene cyclase protein 14 386 4.5E-110 T 17-03-2017 SHXM_RS01455 a390f97e6a82668ac00512a606d7b506 407 SUPERFAMILY SSF51905 13 177 6.24E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS01455 a390f97e6a82668ac00512a606d7b506 407 SUPERFAMILY SSF51905 262 356 6.24E-17 T 17-03-2017 IPR023753 FAD/NAD(P)-binding domain GO:0016491|GO:0055114 SHXM_RS35835 2fa882ecdaa4e3e073780a98d2a28cc6 210 Gene3D G3DSA:3.20.20.60 48 98 2.5E-4 T 17-03-2017 IPR015813 Pyruvate/Phosphoenolpyruvate kinase-like domain GO:0003824 SHXM_RS35435 33bba2e1c081362bd3686621922a4c2b 158 Pfam PF12802 MarR family 40 100 9.7E-13 T 17-03-2017 SHXM_RS35435 33bba2e1c081362bd3686621922a4c2b 158 SMART SM00347 34 137 3.0E-16 T 17-03-2017 IPR000835 MarR-type HTH domain GO:0003700|GO:0006355 SHXM_RS35435 33bba2e1c081362bd3686621922a4c2b 158 SUPERFAMILY SSF46785 7 151 5.39E-28 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS35435 33bba2e1c081362bd3686621922a4c2b 158 Gene3D G3DSA:1.10.10.10 4 153 8.0E-34 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS44340 dd6815f650697fb203c2c1917c083e66 325 Pfam PF03595 Voltage-dependent anion channel 6 304 2.2E-26 T 17-03-2017 IPR004695 Voltage-dependent anion channel GO:0016021|GO:0055085 SHXM_RS09130 d3860cf17efc988f66a52092ce1cc0b6 486 SUPERFAMILY SSF53300 352 447 1.6E-5 T 17-03-2017 IPR002035 von Willebrand factor, type A SHXM_RS27080 1b3d7e097b46081e600a59d395fb7bda 196 Gene3D G3DSA:2.60.60.30 20 185 4.6E-45 T 17-03-2017 SHXM_RS27080 1b3d7e097b46081e600a59d395fb7bda 196 Pfam PF02342 TerD domain 1 182 8.8E-44 T 17-03-2017 IPR003325 TerD domain GO:0006950 SHXM_RS00660 64148ce5cc32c709ccbce35eda2c06d4 170 SUPERFAMILY SSF48452 8 154 9.1E-5 T 17-03-2017 IPR011990 Tetratricopeptide-like helical domain GO:0005515 SHXM_RS00660 64148ce5cc32c709ccbce35eda2c06d4 170 SMART SM01043 18 157 1.3E-9 T 17-03-2017 IPR005158 Bacterial transcriptional activator domain SHXM_RS27655 384bf76d8fb7585adafeef4d07a16f80 248 Pfam PF07987 Domain of unkown function (DUF1775) 28 173 2.3E-53 T 17-03-2017 IPR012533 GLE1, N-terminal, bacteria SHXM_RS44505 81e7219b836a417feb45cf9d5cfa5133 412 Pfam PF10935 Protein of unknown function (DUF2637) 31 178 9.6E-8 T 17-03-2017 IPR021235 Protein of unknown function DUF2637 SHXM_RS44595 a47db9944bccddfb63494298f5ff824a 348 Pfam PF03864 Phage major capsid protein E 39 344 2.5E-27 T 17-03-2017 IPR005564 Major capsid protein GpE GO:0019028 SHXM_RS44595 a47db9944bccddfb63494298f5ff824a 348 Gene3D G3DSA:3.90.1690.10 38 294 3.9E-11 T 17-03-2017 SHXM_RS37225 81ac069384e0461a33f6f86fb956da1a 330 Gene3D G3DSA:1.50.10.20 276 327 1.2E-4 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS37225 81ac069384e0461a33f6f86fb956da1a 330 Gene3D G3DSA:1.50.10.20 145 190 1.2E-4 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS37225 81ac069384e0461a33f6f86fb956da1a 330 SUPERFAMILY SSF48239 65 208 9.81E-9 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS37225 81ac069384e0461a33f6f86fb956da1a 330 SUPERFAMILY SSF48239 277 327 9.81E-9 T 17-03-2017 IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid SHXM_RS19150 a8734d6cc71b81b2f95fa44013cb918c 491 Pfam PF03055 Retinal pigment epithelial membrane protein 38 485 5.1E-98 T 17-03-2017 IPR004294 Carotenoid oxygenase GO:0016702|GO:0055114 SHXM_RS49495 6b128c083ac4b6ba239b8033a221f2f5 254 Pfam PF05861 Bacterial phosphonate metabolism protein (PhnI) 14 203 4.4E-41 T 17-03-2017 IPR008773 Phosphonate metabolism protein PhnI GO:0019634 SHXM_RS08065 0eee1276b216b5b8c21b4fd80a033cd2 149 Pfam PF10025 Uncharacterized conserved protein (DUF2267) 5 135 7.2E-30 T 17-03-2017 IPR018727 Protein of unknown function DUF2267 SHXM_RS32505 860de2cea472630238d388b42429afbd 385 Gene3D G3DSA:2.40.10.10 152 255 3.6E-8 T 17-03-2017 SHXM_RS32505 860de2cea472630238d388b42429afbd 385 SUPERFAMILY SSF50494 129 346 2.18E-16 T 17-03-2017 IPR009003 Peptidase S1, PA clan SHXM_RS48940 186bdbd956b0372f5983005dfe59a718 117 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 3 59 5.7E-21 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS16320 2b54e2ee7e72541742702f207b99428e 112 Pfam PF02656 Domain of unknown function (DUF202) 16 79 5.1E-11 T 17-03-2017 IPR003807 Domain of unknown function DUF202 SHXM_RS07700 a9ea19fc0841cb1b567c75fda606eadc 249 Pfam PF14016 Protein of unknown function (DUF4232) 117 243 2.7E-32 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS17375 757e8fa572f95c07ff857909348e76f3 118 Pfam PF04341 Protein of unknown function, DUF485 25 111 3.3E-30 T 17-03-2017 IPR007436 Protein of unknown function DUF485 SHXM_RS27315 686ff28dd3a4bcd9ba89aeced3a8f13e 171 TIGRFAM TIGR03941 tRNA_deam_assoc: putative tRNA adenosine deaminase-associated protein 2 163 2.5E-27 T 17-03-2017 IPR023869 tRNA adenosine deaminase-associated protein, putative SHXM_RS26565 7bb66c1780da20dffe8a4e97a3fe03cf 270 Pfam PF13490 Putative zinc-finger 11 39 4.7E-7 T 17-03-2017 IPR027383 Putative zinc-finger SHXM_RS24545 65fe98f28c2c45169195cb219b226b45 160 Pfam PF04977 Septum formation initiator 44 121 1.0E-15 T 17-03-2017 IPR007060 Septum formation initiator FtsL/DivIC GO:0007049 SHXM_RS18960 05b7460089b1ea00438a8d240edab092 258 Pfam PF04012 PspA/IM30 family 2 228 1.4E-28 T 17-03-2017 IPR007157 PspA/IM30 SHXM_RS16575 875036b0c3448f6501e390c025b08cfe 611 Pfam PF14667 Polysaccharide biosynthesis C-terminal domain 353 434 3.2E-7 T 17-03-2017 IPR029303 Polysaccharide biosynthesis protein, C-terminal domain SHXM_RS16575 875036b0c3448f6501e390c025b08cfe 611 PRINTS PR00342 Rhesus blood group protein signature 378 403 1.1E-5 T 17-03-2017 IPR002229 Blood group Rhesus C/E/D polypeptide GO:0016020 SHXM_RS16575 875036b0c3448f6501e390c025b08cfe 611 PRINTS PR00342 Rhesus blood group protein signature 104 120 1.1E-5 T 17-03-2017 IPR002229 Blood group Rhesus C/E/D polypeptide GO:0016020 SHXM_RS16575 875036b0c3448f6501e390c025b08cfe 611 PRINTS PR00342 Rhesus blood group protein signature 34 51 1.1E-5 T 17-03-2017 IPR002229 Blood group Rhesus C/E/D polypeptide GO:0016020 SHXM_RS30535 b026c48c77e04ce1b4eacde91ae9f037 488 Pfam PF10935 Protein of unknown function (DUF2637) 16 170 3.4E-40 T 17-03-2017 IPR021235 Protein of unknown function DUF2637 SHXM_RS04365 b56d8d761de95dd20f682e57a7da3f10 355 SUPERFAMILY SSF56801 61 304 2.88E-11 T 17-03-2017 SHXM_RS05375 74d3a7084ab3ee296da8869e81217585 42 Pfam PF08990 Erythronolide synthase docking 18 42 2.0E-12 T 17-03-2017 IPR015083 Polyketide synthase, docking domain GO:0016740|GO:0048037 SHXM_RS29865 11b47256fe8d6d28544ca3d17f7aa430 623 SUPERFAMILY SSF52540 341 599 3.03E-5 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS40345 5a63103d78a04bf16ab971cb979022d0 93 Pfam PF02687 FtsX-like permease family 49 91 1.5E-8 T 17-03-2017 IPR003838 ABC transporter permease protein domain GO:0016020 SHXM_RS35975 c1f1ef0b3ee21747fb042e8242229d27 264 Pfam PF14581 SseB protein C-terminal domain 137 241 1.6E-15 T 17-03-2017 IPR027945 SseB protein, C-terminal SHXM_RS30210 cae49c80d90f8ba7351463b62e35235d 64 Pfam PF04149 Domain of unknown function (DUF397) 5 56 1.2E-11 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS07920 99bdd65e606f4ee5aec55ca8ae8e3086 278 Pfam PF06386 Gas vesicle synthesis protein GvpL/GvpF 7 253 1.3E-63 T 17-03-2017 IPR009430 Gas vesicle protein GvpL/GvpF GO:0031411|GO:0031412 SHXM_RS41835 28e6d2fd8673abf0536ee81bb8ba0ac5 83 SUPERFAMILY SSF50969 14 82 3.92E-14 T 17-03-2017 IPR011044 Quinoprotein amine dehydrogenase, beta chain-like SHXM_RS41835 28e6d2fd8673abf0536ee81bb8ba0ac5 83 Gene3D G3DSA:2.130.10.10 13 82 7.0E-16 T 17-03-2017 IPR015943 WD40/YVTN repeat-like-containing domain GO:0005515 SHXM_RS18155 22e3a5af795bcbdf4a976ac9406ca02e 310 Pfam PF02653 Branched-chain amino acid transport system / permease component 8 294 1.1E-48 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS28685 cf6273bfc3cd79b7a7044777b8231c5c 454 Gene3D G3DSA:3.40.605.10 18 272 1.3E-16 T 17-03-2017 IPR016162 Aldehyde dehydrogenase N-terminal domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS28685 cf6273bfc3cd79b7a7044777b8231c5c 454 Pfam PF00171 Aldehyde dehydrogenase family 40 365 2.4E-12 T 17-03-2017 IPR015590 Aldehyde dehydrogenase domain GO:0008152|GO:0016491|GO:0055114 SHXM_RS28685 cf6273bfc3cd79b7a7044777b8231c5c 454 SUPERFAMILY SSF53720 16 451 3.14E-33 T 17-03-2017 IPR016161 Aldehyde/histidinol dehydrogenase GO:0008152|GO:0016491|GO:0055114 SHXM_RS28685 cf6273bfc3cd79b7a7044777b8231c5c 454 Gene3D G3DSA:3.40.309.10 273 387 1.5E-4 T 17-03-2017 IPR016163 Aldehyde dehydrogenase, C-terminal GO:0008152|GO:0016491|GO:0016620|GO:0055114 SHXM_RS47615 eaebba06ef0763f433ac0e6e813f4d61 402 Gene3D G3DSA:1.20.1250.20 212 388 5.9E-6 T 17-03-2017 SHXM_RS47615 eaebba06ef0763f433ac0e6e813f4d61 402 SUPERFAMILY SSF103473 9 392 5.62E-19 T 17-03-2017 IPR020846 Major facilitator superfamily domain SHXM_RS30620 a6a85f9824e9eca4a3f50eb45b8b3565 621 Pfam PF05140 ResB-like family 63 542 1.6E-128 T 17-03-2017 IPR007816 ResB-like domain SHXM_RS10105 826e19517a5692905aea665500852d48 304 Pfam PF00482 Type II secretion system (T2SS), protein F 117 240 1.2E-10 T 17-03-2017 IPR018076 Type II secretion system F domain SHXM_RS37320 199be38c04cb17836c4bf63e8c8543e4 80 Pfam PF14013 MT0933-like antitoxin protein 16 63 4.4E-15 T 17-03-2017 IPR028037 Antitoxin Rv0909/MT0933 SHXM_RS09005 61b11995a304f57bb7feddf859b05c9b 88 Pfam PF01526 Tn3 transposase DDE domain 2 54 1.1E-9 T 17-03-2017 IPR002513 Tn3 transposase DDE domain GO:0004803|GO:0006313 SHXM_RS07170 7b8d430669ea3b5caa2c9e600832e790 458 Pfam PF03559 NDP-hexose 2,3-dehydratase 251 453 4.1E-77 T 17-03-2017 IPR005212 NDP-hexose 2,3-dehydratase SHXM_RS07170 7b8d430669ea3b5caa2c9e600832e790 458 Pfam PF03559 NDP-hexose 2,3-dehydratase 24 228 3.2E-86 T 17-03-2017 IPR005212 NDP-hexose 2,3-dehydratase SHXM_RS17005 5f040e171546cdce844320478aab4d49 92 Pfam PF05121 Gas vesicle protein K 5 88 1.8E-36 T 17-03-2017 IPR007805 Gas vesicle protein GvpK GO:0031412 SHXM_RS38940 b3b877c73a2ad1d40badec3d18cfd799 123 Pfam PF13309 HTH domain 56 117 7.5E-21 T 17-03-2017 SHXM_RS25970 a2bf628383f9cc6d105529c49b8254c1 242 Gene3D G3DSA:1.10.10.10 178 233 6.7E-9 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS25970 a2bf628383f9cc6d105529c49b8254c1 242 SUPERFAMILY SSF46894 175 233 1.73E-7 T 17-03-2017 IPR016032 Signal transduction response regulator, C-terminal effector GO:0003677|GO:0006355 SHXM_RS24745 727f017b3647acba78467131c1d6ec70 253 Pfam PF10756 Bacterial PH domain 111 172 2.3E-8 T 17-03-2017 IPR019692 Protein of unknown function DUF2581 SHXM_RS38085 f64b55f29decb7e56f45c95593cedf2c 293 Gene3D G3DSA:3.40.50.720 1 282 8.8E-29 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS38085 f64b55f29decb7e56f45c95593cedf2c 293 Pfam PF01370 NAD dependent epimerase/dehydratase family 3 74 2.5E-9 T 17-03-2017 IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain GO:0003824|GO:0050662 SHXM_RS38085 f64b55f29decb7e56f45c95593cedf2c 293 SUPERFAMILY SSF51735 1 286 2.53E-35 T 17-03-2017 IPR016040 NAD(P)-binding domain SHXM_RS19110 7ffac2e8e6addf17f9a23d6e953485b7 196 Pfam PF16640 Bacterial Ig-like domain (group 3) 13 100 1.1E-19 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS19110 7ffac2e8e6addf17f9a23d6e953485b7 196 Pfam PF16640 Bacterial Ig-like domain (group 3) 108 195 3.5E-20 T 17-03-2017 IPR032109 Bacterial Ig-like domain (group 3) SHXM_RS26135 cff0473a9b42bdc3a4d1556e50521118 754 Gene3D G3DSA:3.30.2010.10 88 179 2.9E-14 T 17-03-2017 SHXM_RS26135 cff0473a9b42bdc3a4d1556e50521118 754 Pfam PF01435 Peptidase family M48 97 333 1.1E-14 T 17-03-2017 IPR001915 Peptidase M48 GO:0004222|GO:0006508 SHXM_RS10135 db5cbc875ac9d7a1c172f40c911c4e68 115 Pfam PF13581 Histidine kinase-like ATPase domain 2 86 1.9E-6 T 17-03-2017 IPR003594 Histidine kinase-like ATPase, C-terminal domain SHXM_RS50855 eed6bea06476b2177d246e22a4cc8a34 324 SUPERFAMILY SSF81301 34 145 1.74E-5 T 17-03-2017 SHXM_RS14945 27456da163b850b1e6ad1cbdd455b6de 70 Pfam PF14016 Protein of unknown function (DUF4232) 2 51 1.6E-8 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS13555 1dbf8a451a43c850f3cfd7c38e664058 246 Pfam PF04493 Endonuclease V 48 228 1.9E-61 T 17-03-2017 IPR007581 Endonuclease V GO:0004519|GO:0006281 SHXM_RS13555 1dbf8a451a43c850f3cfd7c38e664058 246 Hamap MF_00801 Endonuclease V [nfi]. 18 238 31.189 T 17-03-2017 IPR007581 Endonuclease V GO:0004519|GO:0006281 SHXM_RS20730 1b84e2c78dae89feb3fd313830fceb00 347 SUPERFAMILY SSF89372 135 295 3.92E-5 T 17-03-2017 SHXM_RS28040 2c904dd3ee0358eb1470d07de7fc94fb 785 ProSitePatterns PS00430 TonB-dependent receptor proteins signature 1. 1 79 - T 17-03-2017 IPR010916 TonB box, conserved site SHXM_RS45230 8d4e54480e730d653b624703c97b10b7 497 Pfam PF04984 Phage tail sheath protein 194 485 2.0E-31 T 17-03-2017 IPR007067 Tail sheath protein SHXM_RS45230 8d4e54480e730d653b624703c97b10b7 497 Pfam PF04984 Phage tail sheath protein 6 126 6.0E-10 T 17-03-2017 IPR007067 Tail sheath protein SHXM_RS07480 10a3e6db2ba972f5c030c2fb06fb1e58 47 TIGRFAM TIGR02107 PQQ_syn_pqqA: coenzyme PQQ precursor peptide PqqA 25 45 7.2E-6 T 17-03-2017 IPR011725 Coenzyme PQQ biosynthesis protein A GO:0018189 SHXM_RS28855 6728dfac96b72041c37b2b10d18bd6a8 252 Pfam PF01925 Sulfite exporter TauE/SafE 10 250 4.0E-31 T 17-03-2017 IPR002781 Transmembrane protein TauE-like GO:0016021 SHXM_RS08150 049ce62207a87675238997f51878cfb2 506 Pfam PF09362 Domain of unknown function (DUF1996) 262 484 6.0E-29 T 17-03-2017 IPR018535 Domain of unknown function DUF1996 SHXM_RS04615 a5dbf60b9e68484d452ca2172c7137f6 488 SUPERFAMILY SSF48208 178 453 1.76E-44 T 17-03-2017 IPR008928 Six-hairpin glycosidase-like GO:0003824 SHXM_RS04615 a5dbf60b9e68484d452ca2172c7137f6 488 Gene3D G3DSA:1.50.10.10 170 391 3.8E-39 T 17-03-2017 IPR012341 Six-hairpin glycosidase GO:0003824 SHXM_RS04615 a5dbf60b9e68484d452ca2172c7137f6 488 Pfam PF03663 Glycosyl hydrolase family 76 178 486 4.9E-44 T 17-03-2017 IPR005198 Glycoside hydrolase, family 76 KEGG: 00052+3.2.1.10|KEGG: 00500+3.2.1.10 SHXM_RS09655 e89c4e60c91c905b944bbcbf50b13b6d 160 Pfam PF13340 Putative transposase of IS4/5 family (DUF4096) 14 87 3.1E-21 T 17-03-2017 IPR025161 Putative transposase IS4/IS5 family SHXM_RS17505 fd9aa620d4ce2b4efad571cd2f8de8a4 426 Pfam PF01384 Phosphate transporter family 168 322 2.0E-46 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS17505 fd9aa620d4ce2b4efad571cd2f8de8a4 426 Pfam PF01384 Phosphate transporter family 22 161 3.6E-32 T 17-03-2017 IPR001204 Phosphate transporter GO:0005315|GO:0006817|GO:0016020 Reactome: R-HSA-427652 SHXM_RS10845 83cb4e83113042c8d2cac54a2c740ce1 70 Pfam PF04149 Domain of unknown function (DUF397) 11 62 1.5E-13 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS28940 a614cff8a15d06d2616ad206971dc325 220 Pfam PF13349 Putative adhesin 20 215 3.8E-9 T 17-03-2017 IPR025164 Putative adhesin SHXM_RS07910 747b3b15bd8762114df86d8d7b3caeff 99 Pfam PF05121 Gas vesicle protein K 12 96 3.4E-35 T 17-03-2017 IPR007805 Gas vesicle protein GvpK GO:0031412 SHXM_RS18620 87e047cc47ff2e1eceb2a2509e191471 462 Pfam PF01882 Protein of unknown function DUF58 223 301 3.4E-21 T 17-03-2017 IPR002881 Domain of unknown function DUF58 SHXM_RS34330 c80031e71d7625a808a32533d698064d 207 Pfam PF01863 Protein of unknown function DUF45 120 188 1.2E-22 T 17-03-2017 IPR002725 Protein of unknown function DUF45 SHXM_RS15245 9dd1b8a901c30210286de30356acc345 2032 SUPERFAMILY SSF52540 1339 1583 2.02E-8 T 17-03-2017 IPR027417 P-loop containing nucleoside triphosphate hydrolase SHXM_RS00425 c23c552c2b342938cf63c2417d5866cf 222 Pfam PF07510 Protein of unknown function (DUF1524) 106 194 2.5E-6 T 17-03-2017 IPR011089 Domain of unknown function DUF1524 SHXM_RS15115 5796024de52d298c945cba52ff349ddc 365 Gene3D G3DSA:3.30.420.10 175 329 4.6E-15 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15115 5796024de52d298c945cba52ff349ddc 365 Pfam PF13683 Integrase core domain 264 328 5.6E-9 T 17-03-2017 IPR001584 Integrase, catalytic core GO:0015074 SHXM_RS15115 5796024de52d298c945cba52ff349ddc 365 SUPERFAMILY SSF53098 177 331 1.31E-16 T 17-03-2017 IPR012337 Ribonuclease H-like domain GO:0003676 SHXM_RS15115 5796024de52d298c945cba52ff349ddc 365 SUPERFAMILY SSF46689 78 157 6.63E-5 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS08360 39906eb448c7d290efeb82130a93c890 79 Pfam PF04149 Domain of unknown function (DUF397) 19 70 1.7E-12 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS15880 41f004a1cb58c4779dbe7ecd86af1eb4 321 Pfam PF13280 WYL domain 152 318 1.3E-31 T 17-03-2017 IPR026881 WYL domain SHXM_RS26615 a04295579a69eb4df7f071ce81fe4be6 621 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 175 308 1.2E-10 T 17-03-2017 SHXM_RS16360 4742bb12c520b5ae38e6b801514f3377 322 Pfam PF13808 DDE_Tnp_1-associated 32 109 1.2E-14 T 17-03-2017 IPR032806 H repeat-associated protein, N-terminal SHXM_RS23940 137826d6289112627b69df1582a65735 180 Pfam PF14016 Protein of unknown function (DUF4232) 37 160 3.3E-18 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS33765 01de18bab9e3a187f1262d5ae878dfcc 269 SUPERFAMILY SSF56112 16 231 5.1E-8 T 17-03-2017 IPR011009 Protein kinase-like domain SHXM_RS09230 35b114894b86c1a3149688a81d7db977 144 Gene3D G3DSA:1.25.10.10 76 125 7.4E-5 T 17-03-2017 IPR011989 Armadillo-like helical SHXM_RS09230 35b114894b86c1a3149688a81d7db977 144 SUPERFAMILY SSF48371 49 130 1.69E-6 T 17-03-2017 IPR016024 Armadillo-type fold GO:0005488 SHXM_RS03480 2076376047d09920516d316eeccb6e3a 361 Pfam PF01757 Acyltransferase family 32 336 3.5E-17 T 17-03-2017 IPR002656 Acyltransferase 3 GO:0016747 SHXM_RS14205 e2a2d79ba7e2ee64c754de4f2fa66a5d 333 Pfam PF02653 Branched-chain amino acid transport system / permease component 58 324 1.0E-42 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS47475 91ceee39a19d87dd87470f35b1fc9887 167 Pfam PF07920 Protein of unknown function (DUF1684) 55 149 7.7E-23 T 17-03-2017 IPR012467 Protein of unknown function DUF1684 SHXM_RS49070 1ceaa0256cfa66326f2baa030c10367c 78 Pfam PF05598 Transposase domain (DUF772) 24 75 1.8E-10 T 17-03-2017 IPR008490 Transposase InsH, N-terminal SHXM_RS09335 1fda976a8063817f6c68a6739d515189 187 Pfam PF01609 Transposase DDE domain 44 179 4.0E-17 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS33475 caf5ef1ee28b725bd95889ce983d019a 295 Pfam PF00482 Type II secretion system (T2SS), protein F 152 278 6.2E-22 T 17-03-2017 IPR018076 Type II secretion system F domain SHXM_RS15065 1a0af38adcda3022c642454fc31cac7e 257 SUPERFAMILY SSF46689 76 157 3.4E-6 T 17-03-2017 IPR009057 Homeodomain-like GO:0003677 SHXM_RS22845 35f52c73882691b9aecb7c7d9a328e80 341 Pfam PF14378 PAP2 superfamily 52 240 5.1E-58 T 17-03-2017 IPR026841 Inositolphosphotransferase Aur1/Ipt1 SHXM_RS00260 d6de9d8437a2b755d93606ce47acbf36 78 Pfam PF04149 Domain of unknown function (DUF397) 16 69 5.9E-18 T 17-03-2017 IPR007278 Domain of unknown function DUF397 SHXM_RS02705 726f1901b48268f1c7b858c1c0e52b47 98 Gene3D G3DSA:3.30.70.270 12 74 8.7E-5 T 17-03-2017 SHXM_RS17170 0ac2f41ddf2d26a1d9e0bed292c5d785 454 Pfam PF06245 Protein of unknown function (DUF1015) 188 449 1.6E-61 T 17-03-2017 IPR008323 Uncharacterised conserved protein UCP033563 SHXM_RS17170 0ac2f41ddf2d26a1d9e0bed292c5d785 454 Pfam PF06245 Protein of unknown function (DUF1015) 13 161 4.4E-46 T 17-03-2017 IPR008323 Uncharacterised conserved protein UCP033563 SHXM_RS22130 e0d3c393e62e3af0ab753c7481d33c55 338 Pfam PF01061 ABC-2 type transporter 85 297 8.6E-15 T 17-03-2017 IPR013525 ABC-2 type transporter GO:0016020 Reactome: R-HSA-1369062 SHXM_RS20230 8dbe8e2a04f293a985198487ddd41565 146 Pfam PF11253 Protein of unknown function (DUF3052) 15 139 2.7E-57 T 17-03-2017 IPR021412 Protein of unknown function DUF3052 SHXM_RS02940 faf4704f0f3858004f417171c136652a 95 Pfam PF05360 yiaA/B two helix domain 14 66 1.6E-18 T 17-03-2017 IPR008024 YiaAB two helix SHXM_RS19995 aecb9d89a7ff3637d1d12e2fd66e9cce 219 Pfam PF07510 Protein of unknown function (DUF1524) 107 212 2.0E-9 T 17-03-2017 IPR011089 Domain of unknown function DUF1524 SHXM_RS34205 c48bca97a8b61af41527163cf0174f4c 75 Pfam PF11305 Protein of unknown function (DUF3107) 1 73 4.3E-28 T 17-03-2017 IPR021456 Protein of unknown function DUF3107 SHXM_RS06855 61bcadea97470d66ce4a80a753c91510 236 Pfam PF03729 Short repeat of unknown function (DUF308) 106 176 1.4E-9 T 17-03-2017 IPR005325 Protein of unknown function DUF308, membrane SHXM_RS06855 61bcadea97470d66ce4a80a753c91510 236 Pfam PF03729 Short repeat of unknown function (DUF308) 163 214 3.0E-8 T 17-03-2017 IPR005325 Protein of unknown function DUF308, membrane SHXM_RS06855 61bcadea97470d66ce4a80a753c91510 236 Pfam PF03729 Short repeat of unknown function (DUF308) 50 119 9.1E-15 T 17-03-2017 IPR005325 Protein of unknown function DUF308, membrane SHXM_RS23800 c375e41ec6acdeb593c7a87a80035a1e 136 Pfam PF12158 Protein of unknown function (DUF3592) 10 133 7.5E-9 T 17-03-2017 IPR021994 Protein of unknown function DUF3592 SHXM_RS24540 c1a2d1743c6792adca73686c23ed49a3 182 Pfam PF04417 Protein of unknown function (DUF501) 36 156 2.1E-36 T 17-03-2017 IPR007511 Protein of unknown function DUF501 SHXM_RS11385 60cae568851cdfe814a0ceeb2839a459 347 Pfam PF02653 Branched-chain amino acid transport system / permease component 60 326 1.2E-37 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS19040 044a3411da1b3dc0b06a4006b1223888 172 Pfam PF14024 Protein of unknown function (DUF4240) 1 128 1.1E-44 T 17-03-2017 IPR025334 Domain of unknown function (DUF4240 SHXM_RS34565 0abb3028f7ef0f09548179361f8bd747 121 Pfam PF06993 Protein of unknown function (DUF1304) 11 117 4.4E-40 T 17-03-2017 IPR009732 Protein of unknown function DUF1304 SHXM_RS25615 2d3908200f0b8331882bc87cd75f22c1 570 Pfam PF07287 Protein of unknown function (DUF1446) 10 337 1.4E-124 T 17-03-2017 IPR010839 Protein of unknown function DUF1446 SHXM_RS32925 bc5adfb28df6c5c182d6e2fc2a6ce475 242 Pfam PF06386 Gas vesicle synthesis protein GvpL/GvpF 7 238 5.7E-58 T 17-03-2017 IPR009430 Gas vesicle protein GvpL/GvpF GO:0031411|GO:0031412 SHXM_RS10420 6e32cdef4a8c5302cbc188daf687bc14 184 Pfam PF10002 Predicted membrane protein (DUF2243) 22 168 4.6E-50 T 17-03-2017 IPR018719 Protein of unknown function DUF2243, membrane SHXM_RS24235 51125178c466686abb32d0972105fc86 303 Gene3D G3DSA:1.10.340.30 117 230 6.4E-18 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS24235 51125178c466686abb32d0972105fc86 303 SUPERFAMILY SSF48150 103 283 1.32E-29 T 17-03-2017 IPR011257 DNA glycosylase GO:0003824|GO:0006281 Reactome: R-HSA-110357 SHXM_RS10100 4c42c92b9e7f5293cdc4a9731421c184 299 Pfam PF00482 Type II secretion system (T2SS), protein F 163 290 5.4E-8 T 17-03-2017 IPR018076 Type II secretion system F domain SHXM_RS21790 4bcb37362010021e5601ea60f3dad213 504 Pfam PF01970 Tripartite tricarboxylate transporter TctA family 20 440 4.2E-146 T 17-03-2017 IPR002823 Protein of unknown function DUF112, transmembrane SHXM_RS22050 08f1689752704a19c4c32a62132bb999 423 Pfam PF00999 Sodium/hydrogen exchanger family 18 373 7.2E-48 T 17-03-2017 IPR006153 Cation/H+ exchanger GO:0006812|GO:0015299|GO:0016021|GO:0055085 SHXM_RS50075 2d74bedd436e39ed9939ed6c7956e731 299 Pfam PF13556 PucR C-terminal helix-turn-helix domain 224 282 3.4E-17 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS16315 e2bd6aebde74d031374f1b853fbcb2c8 121 Pfam PF02656 Domain of unknown function (DUF202) 18 83 3.3E-15 T 17-03-2017 IPR003807 Domain of unknown function DUF202 SHXM_RS49725 4df979f5e57251446cc2b3f5e8dd9a7d 377 Pfam PF02653 Branched-chain amino acid transport system / permease component 65 344 4.3E-29 T 17-03-2017 IPR001851 ABC transporter, permease GO:0005215|GO:0006810|GO:0016020 SHXM_RS29760 e20dce7ed81f116328003596b375c6e2 405 Pfam PF09369 Domain of unknown function (DUF1998) 253 357 3.3E-5 T 17-03-2017 IPR018973 DEAD/DEAH-box helicase, putative SHXM_RS48760 b925e265b87553b4e234bbe632bd8e8b 211 Gene3D G3DSA:1.10.10.10 138 196 2.4E-5 T 17-03-2017 IPR011991 Winged helix-turn-helix DNA-binding domain SHXM_RS24300 5c868f36ad15fcd123698383c545d24e 475 Pfam PF04185 Phosphoesterase family 47 402 1.0E-109 T 17-03-2017 IPR007312 Phosphoesterase GO:0016788 SHXM_RS41195 b4a0fc38851b21078878b89b84f027cf 462 Pfam PF13556 PucR C-terminal helix-turn-helix domain 389 444 1.5E-11 T 17-03-2017 IPR025736 PucR C-terminal helix-turn-helix domain SHXM_RS25690 e62898e836f74fd7422c48e75753d4b4 87 Pfam PF10745 Protein of unknown function (DUF2530) 17 81 8.6E-8 T 17-03-2017 IPR019681 Protein of unknown function DUF2530 SHXM_RS06660 725954b0e558ca93616e0739e9691af6 198 SUPERFAMILY SSF54909 4 98 3.61E-12 T 17-03-2017 IPR011008 Dimeric alpha-beta barrel SHXM_RS06660 725954b0e558ca93616e0739e9691af6 198 Gene3D G3DSA:3.30.70.900 6 89 5.9E-8 T 17-03-2017 SHXM_RS06630 e7cf69f0d67ff6beb1fb57c940c2d1b8 237 Pfam PF14016 Protein of unknown function (DUF4232) 78 215 1.2E-25 T 17-03-2017 IPR025326 Protein of unknown function DUF4232 SHXM_RS42390 de7555c4769a5e55f3fc07dd7ae25f1f 151 Gene3D G3DSA:3.30.360.10 36 127 2.9E-4 T 17-03-2017 SHXM_RS16060 e66eb5c169b54db7eebbc53ff9072b8f 314 TIGRFAM TIGR03843 TIGR03843: conserved hypothetical protein 37 314 3.1E-104 T 17-03-2017 IPR022292 Conserved hypothetical protein CHP03843 SHXM_RS27405 b0484bc508907329280aaf38cce260fa 775 Pfam PF13231 Dolichyl-phosphate-mannose-protein mannosyltransferase 97 254 6.4E-31 T 17-03-2017 SHXM_RS37230 b44b70fd726ca305555b180c1a84d045 64 Pfam PF11248 Protein of unknown function (DUF3046) 1 61 2.7E-32 T 17-03-2017 IPR021408 Protein of unknown function DUF3046 SHXM_RS23630 821d8afab01490074f766269b0863fba 230 Pfam PF08892 YqcI/YcgG family 10 213 3.0E-54 T 17-03-2017 IPR014988 Uncharacterised protein family, YqcI/YcgG SHXM_RS06020 f0313ee6e327797ae7af59f091a36dc8 82 Pfam PF17196 Protein of unknown function (DUF5133) 1 64 2.8E-28 T 17-03-2017 IPR033457 Protein of unknown function DUF5133 SHXM_RS22525 6c2124b2b49e709bc42977b2f0e24933 542 TIGRFAM TIGR01766 tspaseT_teng_C: transposase, IS605 OrfB family 359 426 1.6E-7 T 17-03-2017 IPR010095 Transposase IS605, OrfB, C-terminal SHXM_RS01630 4356ef61454470d0ea8662c7fa384a67 612 Pfam PF13520 Amino acid permease 54 427 2.7E-26 T 17-03-2017 IPR002293 Amino acid/polyamine transporter I GO:0003333|GO:0015171|GO:0016020 SHXM_RS09660 0bddc108a24a989324bd8fa3890aefb8 137 Pfam PF01609 Transposase DDE domain 1 127 2.3E-13 T 17-03-2017 IPR002559 Transposase, IS4-like GO:0003677|GO:0004803|GO:0006313 SHXM_RS38995 86c4d385056e67db789439911eda91e2 495 Pfam PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin 18 451 3.0E-96 T 17-03-2017 IPR001248 Purine-cytosine permease GO:0005215|GO:0016020|GO:0055085 SHXM_RS43075 c9ebf8ee188afcba8330f1162fd5d0d4 215 Pfam PF17197 Domain of unknown function (DUF5134) 35 214 7.9E-37 T 17-03-2017 IPR033458 Protein of unknown function DUF5134 SHXM_RS37235 e127777a2e98a4b6abedcf7884697dac 401 Pfam PF01594 Domain of unknown function DUF20 45 366 1.5E-73 T 17-03-2017 IPR002549 Transmembrane protein TqsA-like