locus-tag	class	description
SHL15_RS00210	COG2801	Transposase and inactivated derivatives
SHL15_RS00280	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS00300	COG1136	(ABC) transporter
SHL15_RS00300	COG0577	efflux transmembrane transporter activity
SHL15_RS00305	COG4585	Histidine kinase
SHL15_RS00310	COG2197	response regulator
SHL15_RS00345	COG1595	DNA-templated transcription, initiation
SHL15_RS00375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SHL15_RS00440	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHL15_RS00500	COG1231	oxidoreductase activity
SHL15_RS00550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHL15_RS00560	COG4221	oxidoreductase activity
SHL15_RS00575	COG3547	Transposase (IS116 IS110 IS902 family)
SHL15_RS00640	COG1486	melibiose metabolic process
SHL15_RS00645	COG1349	DNA-binding transcription factor activity
SHL15_RS00660	COG1175	transmembrane transport
SHL15_RS00670	COG3250	beta-galactosidase activity
SHL15_RS00710	COG3340	Belongs to the peptidase S51 family
SHL15_RS00750	COG4865	methylaspartate mutase activity
SHL15_RS00755	COG0017	Asparaginyl-tRNA synthetase
SHL15_RS00765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHL15_RS00770	COG2423	ornithine cyclodeaminase activity
SHL15_RS00800	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
SHL15_RS00810	COG0142	geranyltranstransferase activity
SHL15_RS00830	COG0789	Transcriptional regulator
SHL15_RS00840	COG2409	Drug exporters of the RND superfamily
SHL15_RS00845	COG1846	Transcriptional regulator
SHL15_RS00850	COG1335	isochorismatase
SHL15_RS00905	COG0583	DNA-binding transcription factor activity
SHL15_RS00915	COG0584	glycerophosphoryl diester phosphodiesterase
SHL15_RS00945	COG3629	intracellular signal transduction
SHL15_RS00945	COG3903	Transcriptional regulator
SHL15_RS00960	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS00970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHL15_RS00975	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SHL15_RS00980	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHL15_RS00985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHL15_RS01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHL15_RS01085	COG0028	Belongs to the TPP enzyme family
SHL15_RS01090	COG3527	Alpha-acetolactate decarboxylase
SHL15_RS01100	COG3842	ATPase activity
SHL15_RS01110	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHL15_RS01115	COG1177	transmembrane transport
SHL15_RS01125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS01140	COG2814	Major facilitator Superfamily
SHL15_RS01175	COG0583	DNA-binding transcription factor activity
SHL15_RS01180	COG0183	Belongs to the thiolase family
SHL15_RS01190	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SHL15_RS01195	COG0604	alcohol dehydrogenase
SHL15_RS01225	COG0586	Pfam SNARE associated Golgi protein
SHL15_RS01255	COG1846	Transcriptional regulator
SHL15_RS01260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SHL15_RS01265	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS01275	COG1309	transcriptional regulator
SHL15_RS01290	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS01295	COG4689	acetoacetate decarboxylase
SHL15_RS01310	COG0174	glutamine synthetase
SHL15_RS01335	COG0596	Alpha beta hydrolase
SHL15_RS01370	COG1129	ABC transporter
SHL15_RS01375	COG4211	Belongs to the binding-protein-dependent transport system permease family
SHL15_RS01380	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHL15_RS01385	COG4948	Mandelate Racemase Muconate Lactonizing
SHL15_RS01395	COG1940	carbohydrate kinase activity
SHL15_RS01395	COG1846	Transcriptional regulator
SHL15_RS01400	COG3345	alpha-galactosidase
SHL15_RS01430	COG1063	alcohol dehydrogenase
SHL15_RS01455	COG1063	alcohol dehydrogenase
SHL15_RS01460	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SHL15_RS01475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHL15_RS01485	COG4977	sequence-specific DNA binding
SHL15_RS01500	COG2175	clavaminate synthase activity
SHL15_RS01510	COG4521	taurine ABC transporter
SHL15_RS01515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHL15_RS01520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SHL15_RS01540	COG2226	methyltransferase
SHL15_RS01550	COG0789	Transcriptional regulator
SHL15_RS01570	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHL15_RS01580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHL15_RS01590	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
SHL15_RS01645	COG2234	aminopeptidase activity
SHL15_RS01660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHL15_RS01675	COG1404	Belongs to the peptidase S8 family
SHL15_RS01695	COG0477	Major facilitator Superfamily
SHL15_RS01700	COG3250	beta-galactosidase activity
SHL15_RS01710	COG0583	DNA-binding transcription factor activity
SHL15_RS01740	COG0596	Alpha beta hydrolase
SHL15_RS01750	COG2267	carboxylic ester hydrolase activity
SHL15_RS01755	COG2508	Transcriptional regulator
SHL15_RS01780	COG0515	serine threonine protein kinase
SHL15_RS01780	COG2815	serine threonine protein kinase
SHL15_RS01835	COG2318	DinB family
SHL15_RS01840	COG0583	DNA-binding transcription factor activity
SHL15_RS01865	COG3973	AAA domain
SHL15_RS01875	COG0604	alcohol dehydrogenase
SHL15_RS01875	COG3321	synthase
SHL15_RS01880	COG0604	alcohol dehydrogenase
SHL15_RS01880	COG3321	synthase
SHL15_RS01905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHL15_RS01920	COG2267	carboxylic ester hydrolase activity
SHL15_RS01930	COG2124	cytochrome p450
SHL15_RS01940	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS01950	COG2197	response regulator
SHL15_RS01965	COG0577	efflux transmembrane transporter activity
SHL15_RS01965	COG1136	(ABC) transporter
SHL15_RS01975	COG0604	alcohol dehydrogenase
SHL15_RS01975	COG3321	synthase
SHL15_RS02005	COG4977	sequence-specific DNA binding
SHL15_RS02045	COG3629	intracellular signal transduction
SHL15_RS02045	COG3903	Transcriptional regulator
SHL15_RS02050	COG3896	Chloramphenicol phosphotransferase-like protein
SHL15_RS02065	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS02070	COG1295	ribonuclease BN
SHL15_RS02090	COG0701	Predicted permease
SHL15_RS02105	COG1482	cell wall glycoprotein biosynthetic process
SHL15_RS02140	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
SHL15_RS02165	COG0375	protein maturation
SHL15_RS02180	COG0298	carbon dioxide binding
SHL15_RS02185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SHL15_RS02195	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
SHL15_RS02200	COG1024	Enoyl-CoA hydratase
SHL15_RS02200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SHL15_RS02255	COG0640	Transcriptional regulator
SHL15_RS02325	COG0667	Aldo Keto reductase
SHL15_RS02345	COG0586	Pfam SNARE associated Golgi protein
SHL15_RS02360	COG3437	response regulator, receiver
SHL15_RS02360	COG3850	Histidine kinase
SHL15_RS02360	COG4999	Histidine kinase
SHL15_RS02360	COG2205	protein histidine kinase activity
SHL15_RS02380	COG0437	4 iron, 4 sulfur cluster binding
SHL15_RS02400	COG3383	formate dehydrogenase (NAD+) activity
SHL15_RS02400	COG0243	molybdopterin cofactor binding
SHL15_RS02405	COG3383	formate dehydrogenase (NAD+) activity
SHL15_RS02405	COG0243	molybdopterin cofactor binding
SHL15_RS02410	COG0709	Synthesizes selenophosphate from selenide and ATP
SHL15_RS02415	COG0546	phosphoglycolate phosphatase activity
SHL15_RS02435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHL15_RS02475	COG2267	carboxylic ester hydrolase activity
SHL15_RS02500	COG0583	DNA-binding transcription factor activity
SHL15_RS02590	COG0477	Major facilitator Superfamily
SHL15_RS02600	COG0009	L-threonylcarbamoyladenylate synthase
SHL15_RS02645	COG1621	beta-fructofuranosidase activity
SHL15_RS02655	COG1175	transmembrane transport
SHL15_RS02660	COG0395	ABC-type sugar transport system, permease component
SHL15_RS02665	COG1621	beta-fructofuranosidase activity
SHL15_RS02670	COG1609	Transcriptional regulator
SHL15_RS02675	COG0656	L-ascorbic acid biosynthetic process
SHL15_RS02685	COG0667	Aldo Keto reductase
SHL15_RS02730	COG1414	Transcriptional regulator
SHL15_RS02735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHL15_RS02755	COG0181	hydroxymethylbilane synthase activity
SHL15_RS02765	COG0842	Transport permease protein
SHL15_RS02775	COG1846	Transcriptional regulator
SHL15_RS02810	COG0366	Alpha amylase catalytic
SHL15_RS02825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SHL15_RS02830	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SHL15_RS02850	COG1252	NADH dehydrogenase
SHL15_RS02915	COG5002	protein histidine kinase activity
SHL15_RS02955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHL15_RS02965	COG0589	response to stress
SHL15_RS03020	COG3485	protocatechuate 3,4-dioxygenase
SHL15_RS03040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SHL15_RS03045	COG0515	serine threonine protein kinase
SHL15_RS03070	COG3647	Membrane
SHL15_RS03080	COG0667	Aldo Keto reductase
SHL15_RS03110	COG0328	RNA-DNA hybrid ribonuclease activity
SHL15_RS03130	COG1396	sequence-specific DNA binding
SHL15_RS03135	COG1191	sigma factor activity
SHL15_RS03155	COG0667	Aldo Keto reductase
SHL15_RS03160	COG0583	DNA-binding transcription factor activity
SHL15_RS03175	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHL15_RS03180	COG0346	lactoylglutathione lyase activity
SHL15_RS03195	COG0667	Aldo Keto reductase
SHL15_RS03205	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS03225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS03230	COG0431	NADPH-dependent FMN reductase
SHL15_RS03235	COG0702	epimerase
SHL15_RS03255	COG0531	amino acid
SHL15_RS03260	COG1940	carbohydrate kinase activity
SHL15_RS03265	COG3250	beta-galactosidase activity
SHL15_RS03320	COG0367	asparagine synthase
SHL15_RS03335	COG0673	inositol 2-dehydrogenase activity
SHL15_RS03355	COG0510	thiamine kinase activity
SHL15_RS03400	COG0596	Alpha beta hydrolase
SHL15_RS03420	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS03425	COG2070	2-Nitropropane dioxygenase
SHL15_RS03430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHL15_RS03490	COG0859	PFAM glycosyl transferase family 9
SHL15_RS03495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SHL15_RS03495	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
SHL15_RS03500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
SHL15_RS03505	COG0297	glycogen (starch) synthase activity
SHL15_RS03520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
SHL15_RS03530	COG2192	nodulation
SHL15_RS03535	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHL15_RS03550	COG2124	cytochrome p450
SHL15_RS03575	COG2376	Dihydroxyacetone kinase
SHL15_RS03580	COG1461	Dihydroxyacetone kinase
SHL15_RS03610	COG1902	pentaerythritol trinitrate reductase activity
SHL15_RS03610	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHL15_RS03640	COG2890	protein-(glutamine-N5) methyltransferase activity
SHL15_RS03660	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHL15_RS03675	COG3458	cephalosporin-C deacetylase activity
SHL15_RS03680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHL15_RS03685	COG2188	Transcriptional regulator
SHL15_RS03690	COG2226	methyltransferase
SHL15_RS03720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SHL15_RS03735	COG2066	Belongs to the glutaminase family
SHL15_RS03750	COG1113	amino acid transport
SHL15_RS03755	COG2186	Transcriptional regulator
SHL15_RS03760	COG1968	undecaprenyl-diphosphatase activity
SHL15_RS03790	COG1175	transmembrane transport
SHL15_RS03795	COG0395	ABC-type sugar transport system, permease component
SHL15_RS03810	COG0346	lactoylglutathione lyase activity
SHL15_RS03820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SHL15_RS03860	COG2340	Cysteine-rich secretory protein family
SHL15_RS03865	COG1733	regulation of RNA biosynthetic process
SHL15_RS03880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHL15_RS03910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHL15_RS03920	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHL15_RS03965	COG2124	cytochrome p450
SHL15_RS03975	COG3548	integral membrane protein
SHL15_RS04005	COG4977	sequence-specific DNA binding
SHL15_RS04005	COG1917	Cupin 2, conserved barrel domain protein
SHL15_RS04010	COG2814	Major facilitator Superfamily
SHL15_RS04025	COG3629	intracellular signal transduction
SHL15_RS04025	COG3903	Transcriptional regulator
SHL15_RS04035	COG0805	protein transport
SHL15_RS04085	COG0561	phosphatase activity
SHL15_RS04095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS04140	COG3209	COG3209 Rhs family protein
SHL15_RS04185	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SHL15_RS04190	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SHL15_RS04195	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SHL15_RS04235	COG2197	response regulator
SHL15_RS04250	COG0464	growth
SHL15_RS04390	COG1971	Probably functions as a manganese efflux pump
SHL15_RS04395	COG0535	radical SAM domain protein
SHL15_RS04425	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SHL15_RS04430	COG3284	Transcriptional regulator
SHL15_RS04435	COG0563	adenylate kinase activity
SHL15_RS04445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHL15_RS04475	COG0535	radical SAM domain protein
SHL15_RS04505	COG2197	response regulator
SHL15_RS04510	COG4585	Histidine kinase
SHL15_RS04525	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS04540	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHL15_RS04540	COG0596	Alpha beta hydrolase
SHL15_RS04545	COG0022	dehydrogenase e1 component
SHL15_RS04550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SHL15_RS04555	COG3199	ATP-NAD kinase
SHL15_RS04560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SHL15_RS04565	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHL15_RS04575	COG1063	alcohol dehydrogenase
SHL15_RS04580	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SHL15_RS04585	COG3265	gluconokinase activity
SHL15_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS04625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SHL15_RS04630	COG1215	transferase activity, transferring glycosyl groups
SHL15_RS04670	COG1349	DNA-binding transcription factor activity
SHL15_RS04680	COG1024	Enoyl-CoA hydratase
SHL15_RS04750	COG1619	proteins homologs of microcin C7 resistance protein MccF
SHL15_RS04755	COG1940	carbohydrate kinase activity
SHL15_RS04765	COG2813	Specifically methylates the guanine in position
SHL15_RS04770	COG0191	fructose-bisphosphate aldolase activity
SHL15_RS04775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHL15_RS04780	COG1349	DNA-binding transcription factor activity
SHL15_RS04790	COG3579	cysteine-type endopeptidase activity
SHL15_RS04830	COG0445	tRNA wobble uridine modification
SHL15_RS04840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHL15_RS04845	COG1660	Displays ATPase and GTPase activities
SHL15_RS04855	COG3345	alpha-galactosidase
SHL15_RS04875	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SHL15_RS04920	COG0584	glycerophosphoryl diester phosphodiesterase
SHL15_RS04945	COG2124	cytochrome p450
SHL15_RS04975	COG0671	phosphoesterase, PA-phosphatase related
SHL15_RS05000	COG2233	PERMEase
SHL15_RS05005	COG0640	Transcriptional regulator
SHL15_RS05010	COG1902	pentaerythritol trinitrate reductase activity
SHL15_RS05015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SHL15_RS05030	COG3509	depolymerase
SHL15_RS05045	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS05065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SHL15_RS05090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHL15_RS05095	COG0477	Major facilitator Superfamily
SHL15_RS05115	COG0432	Pfam Uncharacterised protein family UPF0047
SHL15_RS05120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHL15_RS05125	COG1116	anion transmembrane transporter activity
SHL15_RS05135	COG2072	flavoprotein involved in K transport
SHL15_RS05140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
SHL15_RS05145	COG1132	(ABC) transporter
SHL15_RS05150	COG1846	Transcriptional regulator
SHL15_RS05175	COG1132	(ABC) transporter
SHL15_RS05185	COG0254	rRNA binding
SHL15_RS05200	COG1946	Acyl-CoA thioesterase
SHL15_RS05210	COG2018	Roadblock/LC7 domain
SHL15_RS05280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SHL15_RS05305	COG1846	Transcriptional regulator
SHL15_RS05305	COG1940	carbohydrate kinase activity
SHL15_RS05330	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS05345	COG0586	Pfam SNARE associated Golgi protein
SHL15_RS05385	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS05390	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS05405	COG0492	ferredoxin-NADP+ reductase activity
SHL15_RS05405	COG3118	belongs to the thioredoxin family
SHL15_RS05410	COG1793	dna ligase
SHL15_RS05430	COG3424	synthase
SHL15_RS05435	COG2124	cytochrome p450
SHL15_RS05445	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS05455	COG0242	peptide deformylase activity
SHL15_RS05465	COG3442	glutamine amidotransferase
SHL15_RS05470	COG0205	6-phosphofructokinase activity
SHL15_RS05480	COG1522	sequence-specific DNA binding
SHL15_RS05485	COG1834	amidinotransferase
SHL15_RS05490	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHL15_RS05535	COG0204	Acyl-transferase
SHL15_RS05550	COG0829	nickel cation binding
SHL15_RS05555	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SHL15_RS05560	COG0830	nickel cation binding
SHL15_RS05565	COG0804	urea catabolic process
SHL15_RS05570	COG0832	Belongs to the urease beta subunit family
SHL15_RS05575	COG0831	urea catabolic process
SHL15_RS05585	COG0740	serine-type endopeptidase activity
SHL15_RS05615	COG0156	8-amino-7-oxononanoate synthase activity
SHL15_RS05620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SHL15_RS05625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHL15_RS05630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SHL15_RS05635	COG2226	methyltransferase
SHL15_RS05655	COG0456	acetyltransferase
SHL15_RS05675	COG2963	transposase activity
SHL15_RS05715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHL15_RS05725	COG1796	DNA polymerase
SHL15_RS05725	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHL15_RS05790	COG0517	IMP dehydrogenase activity
SHL15_RS05790	COG0516	GMP reductase activity
SHL15_RS05810	COG1063	alcohol dehydrogenase
SHL15_RS05830	COG0330	HflC and HflK could
SHL15_RS05860	COG0528	UMP kinase activity
SHL15_RS05865	COG0528	UMP kinase activity
SHL15_RS05875	COG0517	IMP dehydrogenase activity
SHL15_RS05930	COG0667	Aldo Keto reductase
SHL15_RS05950	COG1064	alcohol dehydrogenase
SHL15_RS05990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SHL15_RS05995	COG3663	DNA glycosylase
SHL15_RS06015	COG4585	Histidine kinase
SHL15_RS06020	COG2197	response regulator
SHL15_RS06025	COG1940	carbohydrate kinase activity
SHL15_RS06035	COG1595	DNA-templated transcription, initiation
SHL15_RS06045	COG0596	Alpha beta hydrolase
SHL15_RS06060	COG0626	cystathionine gamma-synthase activity
SHL15_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS06100	COG4585	Histidine kinase
SHL15_RS06125	COG1522	sequence-specific DNA binding
SHL15_RS06130	COG0419	ATPase involved in DNA repair
SHL15_RS06135	COG0420	3'-5' exonuclease activity
SHL15_RS06140	COG1739	Uncharacterized protein family UPF0029
SHL15_RS06155	COG1832	CoA-binding protein
SHL15_RS06235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SHL15_RS06250	COG0183	Belongs to the thiolase family
SHL15_RS06260	COG1968	undecaprenyl-diphosphatase activity
SHL15_RS06275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SHL15_RS06300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SHL15_RS06305	COG0747	negative chemotaxis
SHL15_RS06350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SHL15_RS06460	COG3507	Belongs to the glycosyl hydrolase 43 family
SHL15_RS06485	COG0725	ABC transporter, periplasmic molybdate-binding protein
SHL15_RS06510	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHL15_RS06510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHL15_RS06520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHL15_RS06540	COG1716	ATPase activity
SHL15_RS06560	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SHL15_RS06595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHL15_RS06605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHL15_RS06625	COG3706	GGDEF domain
SHL15_RS06630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SHL15_RS06650	COG2018	Roadblock/LC7 domain
SHL15_RS06665	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHL15_RS06670	COG2146	nitrite reductase [NAD(P)H] activity
SHL15_RS06675	COG1414	Transcriptional regulator
SHL15_RS06695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHL15_RS06700	COG4638	Rieske (2fe-2S)
SHL15_RS06705	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS06740	COG2814	Major facilitator Superfamily
SHL15_RS06745	COG4336	lyase activity
SHL15_RS06750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SHL15_RS06755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SHL15_RS06760	COG1984	allophanate hydrolase subunit 2
SHL15_RS06770	COG0438	transferase activity, transferring glycosyl groups
SHL15_RS06805	COG2364	Membrane
SHL15_RS06815	COG2270	Major facilitator Superfamily
SHL15_RS06825	COG3030	protein affecting phage T7 exclusion by the F plasmid
SHL15_RS06830	COG0463	Glycosyl transferase, family 2
SHL15_RS06855	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS06910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SHL15_RS06915	COG0140	phosphoribosyl-ATP diphosphatase activity
SHL15_RS06920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SHL15_RS06925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHL15_RS06925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHL15_RS06930	COG3201	nicotinamide mononucleotide transporter
SHL15_RS06945	COG1940	carbohydrate kinase activity
SHL15_RS06945	COG1846	Transcriptional regulator
SHL15_RS06950	COG0738	Major facilitator superfamily
SHL15_RS06965	COG2233	PERMEase
SHL15_RS06980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHL15_RS06990	COG0531	amino acid
SHL15_RS07010	COG2390	Transcriptional regulator
SHL15_RS07015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SHL15_RS07025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SHL15_RS07040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SHL15_RS07055	COG0194	GDP metabolic process
SHL15_RS07065	COG0284	orotidine-5'-phosphate decarboxylase activity
SHL15_RS07070	COG0167	dihydroorotate dehydrogenase activity
SHL15_RS07075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SHL15_RS07080	COG0505	Belongs to the CarA family
SHL15_RS07090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHL15_RS07095	COG0540	Belongs to the ATCase OTCase family
SHL15_RS07100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SHL15_RS07110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHL15_RS07115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SHL15_RS07120	COG0006	proline dipeptidase activity
SHL15_RS07130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SHL15_RS07135	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SHL15_RS07140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SHL15_RS07145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SHL15_RS07155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SHL15_RS07160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SHL15_RS07180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHL15_RS07195	COG0124	histidyl-tRNA synthetase
SHL15_RS07205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SHL15_RS07210	COG1196	nuclear chromosome segregation
SHL15_RS07215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SHL15_RS07220	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHL15_RS07225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHL15_RS07230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHL15_RS07240	COG2255	four-way junction helicase activity
SHL15_RS07245	COG0632	four-way junction helicase activity
SHL15_RS07250	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SHL15_RS07255	COG0217	transcriptional regulatory protein
SHL15_RS07260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SHL15_RS07265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SHL15_RS07275	COG0438	transferase activity, transferring glycosyl groups
SHL15_RS07280	COG1560	Kdo2-lipid A biosynthetic process
SHL15_RS07285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SHL15_RS07305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHL15_RS07320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SHL15_RS07380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SHL15_RS07430	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHL15_RS07430	COG1648	precorrin-2 dehydrogenase activity
SHL15_RS07435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SHL15_RS07460	COG1464	Belongs to the NlpA lipoprotein family
SHL15_RS07465	COG2011	ABC-type metal ion transport system permease component
SHL15_RS07470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SHL15_RS07500	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS07500	COG0204	Acyl-transferase
SHL15_RS07505	COG2132	Multicopper oxidase
SHL15_RS07510	COG0477	Major facilitator Superfamily
SHL15_RS07525	COG0165	Argininosuccinate lyase
SHL15_RS07530	COG0137	argininosuccinate synthase activity
SHL15_RS07550	COG2205	protein histidine kinase activity
SHL15_RS07555	COG0745	RESPONSE REGULATOR receiver
SHL15_RS07595	COG1438	arginine binding
SHL15_RS07600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHL15_RS07605	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SHL15_RS07610	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SHL15_RS07615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SHL15_RS07625	COG0463	Glycosyl transferase, family 2
SHL15_RS07675	COG1649	PFAM Uncharacterised BCR, COG1649
SHL15_RS07705	COG0072	phenylalanine-tRNA ligase activity
SHL15_RS07705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHL15_RS07710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SHL15_RS07715	COG5002	protein histidine kinase activity
SHL15_RS07720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SHL15_RS07725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SHL15_RS07730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SHL15_RS07735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SHL15_RS07780	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS07785	COG0174	glutamine synthetase
SHL15_RS07795	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SHL15_RS07820	COG4176	ABC-type proline glycine betaine transport system permease component
SHL15_RS07825	COG4175	Glycine betaine
SHL15_RS07825	COG0517	IMP dehydrogenase activity
SHL15_RS07830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHL15_RS07845	COG0564	pseudouridine synthase activity
SHL15_RS07880	COG0805	protein transport
SHL15_RS07885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SHL15_RS07920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHL15_RS07930	COG1609	Transcriptional regulator
SHL15_RS07935	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHL15_RS07940	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHL15_RS07950	COG4122	O-methyltransferase activity
SHL15_RS07955	COG1222	aaa ATPase
SHL15_RS07975	COG0517	IMP dehydrogenase activity
SHL15_RS07975	COG1994	Peptidase M50
SHL15_RS07985	COG2197	response regulator
SHL15_RS07990	COG4166	transmembrane transport
SHL15_RS08000	COG1410	methionine synthase
SHL15_RS08000	COG0646	methionine synthase
SHL15_RS08005	COG1414	Transcriptional regulator
SHL15_RS08010	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SHL15_RS08015	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHL15_RS08020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHL15_RS08025	COG2186	Transcriptional regulator
SHL15_RS08035	COG0215	cysteine-tRNA ligase activity
SHL15_RS08055	COG0598	Magnesium transport protein CorA
SHL15_RS08065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS08070	COG0667	Aldo Keto reductase
SHL15_RS08095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHL15_RS08105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHL15_RS08105	COG1796	DNA polymerase
SHL15_RS08125	COG3012	SEC-C Motif Domain Protein
SHL15_RS08130	COG2186	Transcriptional regulator
SHL15_RS08135	COG3265	gluconokinase activity
SHL15_RS08145	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS08150	COG1063	alcohol dehydrogenase
SHL15_RS08175	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SHL15_RS08180	COG2149	membrane
SHL15_RS08210	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS08220	COG3876	Protein conserved in bacteria
SHL15_RS08255	COG0789	Transcriptional regulator
SHL15_RS08275	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS08285	COG0640	Transcriptional regulator
SHL15_RS08315	COG2851	Citrate transporter
SHL15_RS08320	COG0243	molybdopterin cofactor binding
SHL15_RS08325	COG1309	transcriptional regulator
SHL15_RS08335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SHL15_RS08340	COG2188	Transcriptional regulator
SHL15_RS08380	COG1595	DNA-templated transcription, initiation
SHL15_RS08400	COG2755	lipolytic protein G-D-S-L family
SHL15_RS08415	COG1725	Transcriptional regulator
SHL15_RS08440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHL15_RS08445	COG0587	DNA-directed DNA polymerase activity
SHL15_RS08465	COG1126	abc transporter atp-binding protein
SHL15_RS08475	COG0765	amino acid transport
SHL15_RS08500	COG1799	cell septum assembly
SHL15_RS08505	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS08510	COG0477	Major facilitator Superfamily
SHL15_RS08520	COG0671	phosphoesterase, PA-phosphatase related
SHL15_RS08530	COG1652	LysM domain
SHL15_RS08545	COG1160	GTP binding
SHL15_RS08555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SHL15_RS08580	COG3541	Predicted nucleotidyltransferase
SHL15_RS08585	COG1397	ADP-ribosylglycohydrolase
SHL15_RS08590	COG1187	pseudouridine synthase activity
SHL15_RS08595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SHL15_RS08600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SHL15_RS08615	COG0686	Belongs to the AlaDH PNT family
SHL15_RS08625	COG0494	nUDIX hydrolase
SHL15_RS08630	COG0504	CTP synthase activity
SHL15_RS08635	COG3387	PFAM Glycoside hydrolase 15-related
SHL15_RS08650	COG0297	glycogen (starch) synthase activity
SHL15_RS08660	COG0497	DNA recombination
SHL15_RS08665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHL15_RS08685	COG1120	ATPase activity
SHL15_RS08690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHL15_RS08695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHL15_RS08700	COG0647	UMP catabolic process
SHL15_RS08735	COG2094	Belongs to the DNA glycosylase MPG family
SHL15_RS08745	COG1881	PFAM PEBP family protein
SHL15_RS08765	COG1119	ATPase activity
SHL15_RS08785	COG2197	response regulator
SHL15_RS08790	COG3850	Histidine kinase
SHL15_RS08810	COG1131	(ABC) transporter
SHL15_RS08810	COG0842	Transport permease protein
SHL15_RS08810	COG1716	ATPase activity
SHL15_RS08815	COG0560	Phosphoserine phosphatase
SHL15_RS08815	COG3830	Belongs to the UPF0237 family
SHL15_RS08835	COG2186	Transcriptional regulator
SHL15_RS08895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SHL15_RS08915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHL15_RS08920	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHL15_RS08940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHL15_RS08945	COG1063	alcohol dehydrogenase
SHL15_RS08960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SHL15_RS08975	COG3387	PFAM Glycoside hydrolase 15-related
SHL15_RS09025	COG0488	(ABC) transporter
SHL15_RS09045	COG2267	carboxylic ester hydrolase activity
SHL15_RS09050	COG0235	Class ii aldolase
SHL15_RS09070	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SHL15_RS09075	COG1492	cobalamin metabolic process
SHL15_RS09095	COG1797	cobyrinic acid a,c-diamide synthase activity
SHL15_RS09130	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
SHL15_RS09155	COG0765	amino acid transport
SHL15_RS09160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHL15_RS09165	COG1104	cysteine desulfurase activity
SHL15_RS09170	COG0456	acetyltransferase
SHL15_RS09175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHL15_RS09180	COG1917	Cupin 2, conserved barrel domain protein
SHL15_RS09185	COG5285	phytanoyl-CoA dioxygenase
SHL15_RS09215	COG1414	Transcriptional regulator
SHL15_RS09230	COG2252	PERMEase
SHL15_RS09240	COG2186	Transcriptional regulator
SHL15_RS09285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHL15_RS09290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHL15_RS09295	COG1349	DNA-binding transcription factor activity
SHL15_RS09310	COG0395	ABC-type sugar transport system, permease component
SHL15_RS09315	COG1063	alcohol dehydrogenase
SHL15_RS09325	COG1309	transcriptional regulator
SHL15_RS09365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHL15_RS09370	COG2171	N-acyltransferase activity
SHL15_RS09375	COG3226	Transcriptional regulator
SHL15_RS09380	COG2076	Multidrug Resistance protein
SHL15_RS09385	COG2151	metal-sulfur cluster biosynthetic enzyme
SHL15_RS09390	COG0822	iron-sulfur transferase activity
SHL15_RS09395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHL15_RS09400	COG0396	ATPase activity
SHL15_RS09410	COG0719	Fe-S assembly protein
SHL15_RS09425	COG2746	aminoglycoside 3-N-acetyltransferase activity
SHL15_RS09430	COG1131	(ABC) transporter
SHL15_RS09440	COG1612	heme a metabolic process
SHL15_RS09460	COG0109	protoheme IX farnesyltransferase activity
SHL15_RS09470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SHL15_RS09485	COG0363	glucosamine-6-phosphate deaminase activity
SHL15_RS09490	COG0395	ABC-type sugar transport system, permease component
SHL15_RS09495	COG1175	transmembrane transport
SHL15_RS09500	COG1653	transport
SHL15_RS09505	COG0366	Alpha amylase catalytic
SHL15_RS09510	COG1653	transport
SHL15_RS09515	COG1695	Transcriptional regulator
SHL15_RS09520	COG1136	(ABC) transporter
SHL15_RS09530	COG0166	Belongs to the GPI family
SHL15_RS09545	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SHL15_RS09550	COG0149	triose-phosphate isomerase activity
SHL15_RS09555	COG0126	phosphoglycerate kinase activity
SHL15_RS09560	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SHL15_RS09570	COG1481	regulation of sporulation
SHL15_RS09575	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SHL15_RS09580	COG1660	Displays ATPase and GTPase activities
SHL15_RS09585	COG0322	excinuclease ABC activity
SHL15_RS09600	COG1609	Transcriptional regulator
SHL15_RS09610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHL15_RS09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHL15_RS09630	COG0765	amino acid transport
SHL15_RS09640	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SHL15_RS09645	COG0477	Major facilitator Superfamily
SHL15_RS09650	COG0387	Pfam Sodium calcium exchanger
SHL15_RS09675	COG0556	nucleotide-excision repair
SHL15_RS09685	COG0584	glycerophosphoryl diester phosphodiesterase
SHL15_RS09690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHL15_RS09700	COG2313	pseudouridylate synthase activity
SHL15_RS09715	COG0598	Magnesium transport protein CorA
SHL15_RS09745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS09750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHL15_RS09780	COG1132	(ABC) transporter
SHL15_RS09820	COG1953	Uracil, thiamine, allantoin
SHL15_RS09825	COG1802	Transcriptional regulator
SHL15_RS09845	COG2226	methyltransferase
SHL15_RS09865	COG0237	dephospho-CoA kinase activity
SHL15_RS09880	COG0539	negative regulation of cytoplasmic translation
SHL15_RS09890	COG1643	Atp-dependent helicase
SHL15_RS09925	COG2050	protein possibly involved in aromatic compounds catabolism
SHL15_RS09985	COG0737	Belongs to the 5'-nucleotidase family
SHL15_RS10005	COG0287	Prephenate dehydrogenase
SHL15_RS10005	COG1605	Chorismate mutase
SHL15_RS10025	COG1309	transcriptional regulator
SHL15_RS10045	COG0067	glutamate synthase
SHL15_RS10045	COG0069	glutamate synthase activity
SHL15_RS10045	COG0070	glutamate synthase
SHL15_RS10055	COG1397	ADP-ribosylglycohydrolase
SHL15_RS10075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS10080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHL15_RS10085	COG2301	Belongs to the HpcH HpaI aldolase family
SHL15_RS10090	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SHL15_RS10100	COG0159	tryptophan synthase activity
SHL15_RS10105	COG0133	tryptophan synthase activity
SHL15_RS10110	COG0134	indole-3-glycerol-phosphate synthase activity
SHL15_RS10135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SHL15_RS10160	COG0107	imidazoleglycerol-phosphate synthase activity
SHL15_RS10165	COG0251	oxidation-reduction process
SHL15_RS10170	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SHL15_RS10175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SHL15_RS10185	COG0131	Imidazoleglycerol-phosphate dehydratase
SHL15_RS10190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHL15_RS10195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SHL15_RS10215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SHL15_RS10235	COG1432	Conserved Protein
SHL15_RS10240	COG0587	DNA-directed DNA polymerase activity
SHL15_RS10295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SHL15_RS10305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SHL15_RS10310	COG3599	regulation of cell shape
SHL15_RS10320	COG1799	cell septum assembly
SHL15_RS10330	COG1496	oxidoreductase activity
SHL15_RS10335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SHL15_RS10345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SHL15_RS10355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SHL15_RS10360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHL15_RS10365	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SHL15_RS10370	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SHL15_RS10375	COG0768	penicillin binding
SHL15_RS10385	COG0275	rRNA processing
SHL15_RS10395	COG0714	Associated with various cellular activities
SHL15_RS10415	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHL15_RS10425	COG1129	ABC transporter
SHL15_RS10435	COG1309	transcriptional regulator
SHL15_RS10460	COG0352	thiamine-phosphate diphosphorylase activity
SHL15_RS10480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHL15_RS10480	COG2022	thiamine diphosphate biosynthetic process
SHL15_RS10490	COG2022	thiamine diphosphate biosynthetic process
SHL15_RS10495	COG0515	serine threonine protein kinase
SHL15_RS10495	COG2815	serine threonine protein kinase
SHL15_RS10500	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SHL15_RS10510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHL15_RS10515	COG2193	ferroxidase activity
SHL15_RS10525	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SHL15_RS10535	COG0205	6-phosphofructokinase activity
SHL15_RS10570	COG1940	carbohydrate kinase activity
SHL15_RS10580	COG0003	Pfam Anion-transporting ATPase
SHL15_RS10655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHL15_RS10660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SHL15_RS10665	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SHL15_RS10670	COG0723	plastoquinol--plastocyanin reductase activity
SHL15_RS10675	COG2010	Cytochrome c
SHL15_RS10680	COG1845	cytochrome c oxidase, subunit III
SHL15_RS10690	COG1376	ErfK ybiS ycfS ynhG family protein
SHL15_RS10700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHL15_RS10705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SHL15_RS10715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS10735	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SHL15_RS10740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SHL15_RS10745	COG2197	response regulator
SHL15_RS10750	COG4585	Histidine kinase
SHL15_RS10775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHL15_RS10795	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SHL15_RS10800	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SHL15_RS10800	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SHL15_RS10815	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SHL15_RS10820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SHL15_RS10825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHL15_RS10830	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHL15_RS10840	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SHL15_RS10885	COG0321	lipoyl(octanoyl) transferase activity
SHL15_RS10890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SHL15_RS10920	COG2867	negative regulation of translational initiation
SHL15_RS10925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHL15_RS10930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHL15_RS10940	COG0662	Cupin 2, conserved barrel domain protein
SHL15_RS10960	COG0174	glutamine synthetase
SHL15_RS10965	COG1335	isochorismatase
SHL15_RS10985	COG0501	Belongs to the peptidase M48B family
SHL15_RS11025	COG2267	carboxylic ester hydrolase activity
SHL15_RS11040	COG0745	RESPONSE REGULATOR receiver
SHL15_RS11055	COG3547	Transposase (IS116 IS110 IS902 family)
SHL15_RS11115	COG0366	Alpha amylase catalytic
SHL15_RS11120	COG3833	ABC-type maltose transport systems, permease component
SHL15_RS11125	COG1175	transmembrane transport
SHL15_RS11135	COG1609	Transcriptional regulator
SHL15_RS11145	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SHL15_RS11155	COG3511	phospholipase C
SHL15_RS11175	COG0174	glutamine synthetase
SHL15_RS11185	COG1959	2 iron, 2 sulfur cluster binding
SHL15_RS11230	COG2814	Major facilitator Superfamily
SHL15_RS11245	COG0477	Major facilitator Superfamily
SHL15_RS11250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SHL15_RS11275	COG1994	Peptidase M50
SHL15_RS11300	COG3547	Transposase (IS116 IS110 IS902 family)
SHL15_RS11340	COG2837	iron assimilation
SHL15_RS11345	COG0672	)-iron permease
SHL15_RS11370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHL15_RS11375	COG2814	Major facilitator Superfamily
SHL15_RS11390	COG1686	Belongs to the peptidase S11 family
SHL15_RS11405	COG2259	Doxx family
SHL15_RS11420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHL15_RS11445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SHL15_RS11475	COG3022	response to hydroperoxide
SHL15_RS11480	COG0800	Aldolase
SHL15_RS11495	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SHL15_RS11505	COG2030	dehydratase
SHL15_RS11510	COG4585	Histidine kinase
SHL15_RS11540	COG0477	Major facilitator Superfamily
SHL15_RS11550	COG2247	cell wall binding repeat
SHL15_RS11550	COG0860	N-Acetylmuramoyl-L-alanine amidase
SHL15_RS11585	COG0438	transferase activity, transferring glycosyl groups
SHL15_RS11590	COG1309	transcriptional regulator
SHL15_RS11620	COG1657	PFAM Prenyltransferase squalene oxidase
SHL15_RS11635	COG3845	ABC transporter
SHL15_RS11655	COG3619	membrane
SHL15_RS11660	COG2124	cytochrome p450
SHL15_RS11665	COG0183	Belongs to the thiolase family
SHL15_RS11675	COG4122	O-methyltransferase activity
SHL15_RS11715	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHL15_RS11790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHL15_RS11800	COG1358	cellular component organization or biogenesis
SHL15_RS11845	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SHL15_RS11850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHL15_RS11860	COG0477	Major facilitator Superfamily
SHL15_RS11865	COG1309	transcriptional regulator
SHL15_RS11880	COG0789	Transcriptional regulator
SHL15_RS11895	COG1741	Belongs to the pirin family
SHL15_RS11910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHL15_RS11915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHL15_RS11920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHL15_RS11955	COG2130	NADP-dependent
SHL15_RS11960	COG1764	response to oxidative stress
SHL15_RS12000	COG4214	carbohydrate transport
SHL15_RS12010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHL15_RS12045	COG3386	PFAM SMP-30 Gluconolaconase
SHL15_RS12050	COG1414	Transcriptional regulator
SHL15_RS12075	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS12080	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SHL15_RS12080	COG0825	malonyl-CoA metabolic process
SHL15_RS12085	COG1404	Belongs to the peptidase S8 family
SHL15_RS12110	COG1077	Cell shape determining protein MreB Mrl
SHL15_RS12130	COG0515	serine threonine protein kinase
SHL15_RS12130	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHL15_RS12135	COG0367	asparagine synthase
SHL15_RS12185	COG1487	ribonuclease activity
SHL15_RS12210	COG1070	Carbohydrate kinase
SHL15_RS12225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHL15_RS12235	COG0358	DNA primase activity
SHL15_RS12245	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SHL15_RS12255	COG2949	membrane
SHL15_RS12260	COG0243	molybdopterin cofactor binding
SHL15_RS12300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHL15_RS12305	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHL15_RS12305	COG2146	nitrite reductase [NAD(P)H] activity
SHL15_RS12315	COG2130	NADP-dependent
SHL15_RS12320	COG1309	transcriptional regulator
SHL15_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS12330	COG0395	ABC-type sugar transport system, permease component
SHL15_RS12335	COG1175	transmembrane transport
SHL15_RS12350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHL15_RS12350	COG0574	Belongs to the PEP-utilizing enzyme family
SHL15_RS12355	COG1846	Transcriptional regulator
SHL15_RS12355	COG1940	carbohydrate kinase activity
SHL15_RS12360	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
SHL15_RS12390	COG0477	Major facilitator Superfamily
SHL15_RS12400	COG0423	glycine-tRNA ligase activity
SHL15_RS12415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SHL15_RS12425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHL15_RS12430	COG1381	Involved in DNA repair and RecF pathway recombination
SHL15_RS12470	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS12475	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS12505	COG1309	transcriptional regulator
SHL15_RS12515	COG0702	epimerase
SHL15_RS12545	COG0747	negative chemotaxis
SHL15_RS12555	COG0444	Belongs to the ABC transporter superfamily
SHL15_RS12560	COG4608	Belongs to the ABC transporter superfamily
SHL15_RS12565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHL15_RS12580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHL15_RS12610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SHL15_RS12630	COG2315	Protein conserved in bacteria
SHL15_RS12640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SHL15_RS12650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS12655	COG4948	Mandelate Racemase Muconate Lactonizing
SHL15_RS12665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHL15_RS12670	COG1234	tRNA 3'-trailer cleavage
SHL15_RS12675	COG0537	adenosine 5'-monophosphoramidase activity
SHL15_RS12680	COG4946	Tricorn protease homolog
SHL15_RS12680	COG0793	Belongs to the peptidase S41A family
SHL15_RS12700	COG2070	2-Nitropropane dioxygenase
SHL15_RS12705	COG0484	heat shock protein binding
SHL15_RS12710	COG1420	regulation of RNA biosynthetic process
SHL15_RS12745	COG0481	GTPase activity
SHL15_RS12750	COG0268	Binds directly to 16S ribosomal RNA
SHL15_RS12765	COG2353	YceI-like domain
SHL15_RS12780	COG1596	polysaccharide export
SHL15_RS12780	COG1555	photosystem II stabilization
SHL15_RS12790	COG1307	EDD domain protein, DegV family
SHL15_RS12800	COG0495	leucyl-tRNA aminoacylation
SHL15_RS12810	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SHL15_RS12835	COG0588	phosphoglycerate mutase activity
SHL15_RS12850	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SHL15_RS12855	COG0501	Belongs to the peptidase M48B family
SHL15_RS12870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SHL15_RS12880	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SHL15_RS12895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHL15_RS12900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHL15_RS12910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SHL15_RS12915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SHL15_RS12920	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SHL15_RS12925	COG0371	Dehydrogenase
SHL15_RS12935	COG1530	ribonuclease E activity
SHL15_RS12960	COG0772	Belongs to the SEDS family
SHL15_RS12965	COG0768	penicillin binding
SHL15_RS12980	COG1077	Cell shape determining protein MreB Mrl
SHL15_RS12985	COG0105	UTP biosynthetic process
SHL15_RS12995	COG0285	dihydrofolate synthase activity
SHL15_RS13000	COG0525	valine-tRNA ligase activity
SHL15_RS13010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SHL15_RS13015	COG0740	serine-type endopeptidase activity
SHL15_RS13020	COG0740	serine-type endopeptidase activity
SHL15_RS13025	COG0544	peptidyl-prolyl cis-trans isomerase activity
SHL15_RS13045	COG3594	Acyltransferase
SHL15_RS13060	COG4552	Acetyltransferase involved in intracellular survival and related
SHL15_RS13075	COG1113	amino acid transport
SHL15_RS13085	COG1113	amino acid transport
SHL15_RS13090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SHL15_RS13095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SHL15_RS13110	COG2755	lipolytic protein G-D-S-L family
SHL15_RS13140	COG0346	lactoylglutathione lyase activity
SHL15_RS13215	COG0577	efflux transmembrane transporter activity
SHL15_RS13215	COG1136	(ABC) transporter
SHL15_RS13220	COG3409	Peptidoglycan-binding domain 1 protein
SHL15_RS13265	COG0697	spore germination
SHL15_RS13270	COG1846	Transcriptional regulator
SHL15_RS13290	COG1595	DNA-templated transcription, initiation
SHL15_RS13300	COG1131	(ABC) transporter
SHL15_RS13320	COG0668	transmembrane transport
SHL15_RS13345	COG1653	transport
SHL15_RS13350	COG1175	transmembrane transport
SHL15_RS13355	COG0395	ABC-type sugar transport system, permease component
SHL15_RS13360	COG1486	melibiose metabolic process
SHL15_RS13370	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SHL15_RS13380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHL15_RS13415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHL15_RS13435	COG1136	(ABC) transporter
SHL15_RS13480	COG0629	single-stranded DNA binding
SHL15_RS13485	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SHL15_RS13515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHL15_RS13580	COG0297	glycogen (starch) synthase activity
SHL15_RS13585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SHL15_RS13605	COG0438	transferase activity, transferring glycosyl groups
SHL15_RS13645	COG1022	Amp-dependent synthetase and ligase
SHL15_RS13665	COG1131	(ABC) transporter
SHL15_RS13685	COG3962	Belongs to the TPP enzyme family
SHL15_RS13690	COG3718	enzyme involved in inositol metabolism
SHL15_RS13700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS13715	COG2409	Drug exporters of the RND superfamily
SHL15_RS13740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SHL15_RS13765	COG1609	Transcriptional regulator
SHL15_RS13770	COG1129	ABC transporter
SHL15_RS13780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS13785	COG1869	D-ribose catabolic process
SHL15_RS13800	COG0673	inositol 2-dehydrogenase activity
SHL15_RS13805	COG1609	Transcriptional regulator
SHL15_RS13815	COG0456	acetyltransferase
SHL15_RS13815	COG1846	Transcriptional regulator
SHL15_RS13835	COG1472	Belongs to the glycosyl hydrolase 3 family
SHL15_RS13880	COG0028	Belongs to the TPP enzyme family
SHL15_RS13890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHL15_RS13910	COG1946	Acyl-CoA thioesterase
SHL15_RS13925	COG1309	transcriptional regulator
SHL15_RS13930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHL15_RS13945	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS13965	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SHL15_RS14000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHL15_RS14005	COG0589	response to stress
SHL15_RS14015	COG4977	sequence-specific DNA binding
SHL15_RS14020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SHL15_RS14060	COG1487	ribonuclease activity
SHL15_RS14075	COG0395	ABC-type sugar transport system, permease component
SHL15_RS14100	COG3979	chitinase
SHL15_RS14110	COG0745	RESPONSE REGULATOR receiver
SHL15_RS14135	COG0406	alpha-ribazole phosphatase activity
SHL15_RS14160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS14190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHL15_RS14195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHL15_RS14200	COG0765	amino acid transport
SHL15_RS14205	COG0765	amino acid transport
SHL15_RS14210	COG1126	abc transporter atp-binding protein
SHL15_RS14230	COG3397	chitin binding
SHL15_RS14250	COG2186	Transcriptional regulator
SHL15_RS14275	COG1940	carbohydrate kinase activity
SHL15_RS14280	COG0673	inositol 2-dehydrogenase activity
SHL15_RS14285	COG4702	Belongs to the UPF0303 family
SHL15_RS14300	COG0706	membrane insertase activity
SHL15_RS14450	COG2271	Major facilitator Superfamily
SHL15_RS14455	COG2733	membrane
SHL15_RS14465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SHL15_RS14505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHL15_RS14520	COG4555	ABC transporter
SHL15_RS14535	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SHL15_RS14540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SHL15_RS14545	COG1263	PTS System
SHL15_RS14550	COG1263	PTS System
SHL15_RS14585	COG1113	amino acid transport
SHL15_RS14595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SHL15_RS14605	COG1335	isochorismatase
SHL15_RS14640	COG0277	FAD linked oxidase domain protein
SHL15_RS14650	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SHL15_RS14745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHL15_RS14760	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SHL15_RS14770	COG1678	Uncharacterized ACR, COG1678
SHL15_RS14775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHL15_RS14780	COG0776	regulation of translation
SHL15_RS14790	COG3973	AAA domain
SHL15_RS14810	COG2223	nitrite transmembrane transporter activity
SHL15_RS14845	COG0583	DNA-binding transcription factor activity
SHL15_RS14855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SHL15_RS14860	COG0793	Belongs to the peptidase S41A family
SHL15_RS14865	COG2177	Part of the ABC transporter FtsEX involved in
SHL15_RS14870	COG2884	Cell division ATP-binding protein ftsE
SHL15_RS14885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SHL15_RS14890	COG0515	serine threonine protein kinase
SHL15_RS14895	COG0515	serine threonine protein kinase
SHL15_RS14900	COG1674	ftsk spoiiie
SHL15_RS14905	COG1653	transport
SHL15_RS14910	COG1175	transmembrane transport
SHL15_RS14915	COG0395	ABC-type sugar transport system, permease component
SHL15_RS14920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHL15_RS14925	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHL15_RS14930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHL15_RS14930	COG0463	Glycosyl transferase, family 2
SHL15_RS14935	COG1764	response to oxidative stress
SHL15_RS14940	COG1846	Transcriptional regulator
SHL15_RS14955	COG1215	transferase activity, transferring glycosyl groups
SHL15_RS14970	COG1134	teichoic acid transport
SHL15_RS14975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SHL15_RS14980	COG1215	transferase activity, transferring glycosyl groups
SHL15_RS14990	COG2902	Dehydrogenase
SHL15_RS15015	COG0653	protein targeting
SHL15_RS15025	COG3214	Protein conserved in bacteria
SHL15_RS15030	COG2197	response regulator
SHL15_RS15035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SHL15_RS15045	COG0823	Involved in the tonB-independent uptake of proteins
SHL15_RS15050	COG5000	phosphorelay sensor kinase activity
SHL15_RS15050	COG5002	protein histidine kinase activity
SHL15_RS15055	COG0745	RESPONSE REGULATOR receiver
SHL15_RS15060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SHL15_RS15080	COG0714	Associated with various cellular activities
SHL15_RS15125	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SHL15_RS15130	COG0681	Belongs to the peptidase S26 family
SHL15_RS15140	COG1482	cell wall glycoprotein biosynthetic process
SHL15_RS15195	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SHL15_RS15200	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SHL15_RS15200	COG0778	Nitroreductase
SHL15_RS15230	COG1316	TRANSCRIPTIONal
SHL15_RS15235	COG1316	TRANSCRIPTIONal
SHL15_RS15245	COG1316	TRANSCRIPTIONal
SHL15_RS15255	COG1316	TRANSCRIPTIONal
SHL15_RS15270	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SHL15_RS15295	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SHL15_RS15310	COG2205	protein histidine kinase activity
SHL15_RS15315	COG0745	RESPONSE REGULATOR receiver
SHL15_RS15320	COG3104	oligopeptide transport
SHL15_RS15335	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS15340	COG1191	sigma factor activity
SHL15_RS15360	COG1228	amidohydrolase
SHL15_RS15375	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SHL15_RS15415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SHL15_RS15425	COG4221	oxidoreductase activity
SHL15_RS15440	COG2755	lipolytic protein G-D-S-L family
SHL15_RS15445	COG0183	Belongs to the thiolase family
SHL15_RS15480	COG1136	(ABC) transporter
SHL15_RS15480	COG0577	efflux transmembrane transporter activity
SHL15_RS15485	COG0577	efflux transmembrane transporter activity
SHL15_RS15490	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SHL15_RS15495	COG1252	NADH dehydrogenase
SHL15_RS15515	COG0148	phosphopyruvate hydratase activity
SHL15_RS15530	COG2124	cytochrome p450
SHL15_RS15590	COG0789	Transcriptional regulator
SHL15_RS15600	COG0577	efflux transmembrane transporter activity
SHL15_RS15605	COG1136	(ABC) transporter
SHL15_RS15610	COG0477	Major facilitator Superfamily
SHL15_RS15640	COG4585	Histidine kinase
SHL15_RS15655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SHL15_RS15660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SHL15_RS15665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SHL15_RS15670	COG0193	aminoacyl-tRNA hydrolase activity
SHL15_RS15680	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SHL15_RS15690	COG1309	transcriptional regulator
SHL15_RS15700	COG4106	trans-aconitate 2-methyltransferase activity
SHL15_RS15710	COG2197	response regulator
SHL15_RS15730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SHL15_RS15770	COG0488	(ABC) transporter
SHL15_RS15780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SHL15_RS15785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SHL15_RS15790	COG3584	3D domain protein
SHL15_RS15790	COG3583	domain protein
SHL15_RS15795	COG0084	hydrolase, TatD family'
SHL15_RS15835	COG0310	cobalt ion transport
SHL15_RS15845	COG1122	ATPase activity
SHL15_RS15875	COG0442	prolyl-tRNA aminoacylation
SHL15_RS15880	COG2409	Drug exporters of the RND superfamily
SHL15_RS15890	COG0793	Belongs to the peptidase S41A family
SHL15_RS15890	COG4946	Tricorn protease homolog
SHL15_RS15900	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS15905	COG2267	carboxylic ester hydrolase activity
SHL15_RS15910	COG2072	flavoprotein involved in K transport
SHL15_RS15940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHL15_RS15945	COG0521	Mo-molybdopterin cofactor biosynthetic process
SHL15_RS15945	COG0315	cyclic pyranopterin monophosphate synthase activity
SHL15_RS15950	COG0315	cyclic pyranopterin monophosphate synthase activity
SHL15_RS15960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SHL15_RS15965	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SHL15_RS15980	COG3263	regulation of cellular component size
SHL15_RS15995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SHL15_RS16020	COG3191	aminopeptidase activity
SHL15_RS16025	COG1376	ErfK ybiS ycfS ynhG family protein
SHL15_RS16040	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHL15_RS16040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHL15_RS16040	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SHL15_RS16045	COG1105	Belongs to the carbohydrate kinase PfkB family
SHL15_RS16050	COG1349	DNA-binding transcription factor activity
SHL15_RS16055	COG0477	Major facilitator Superfamily
SHL15_RS16075	COG1247	-acetyltransferase
SHL15_RS16080	COG3384	dioxygenase
SHL15_RS16085	COG1846	Transcriptional regulator
SHL15_RS16105	COG1414	Transcriptional regulator
SHL15_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS16185	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS16205	COG0277	FAD linked oxidase domain protein
SHL15_RS16225	COG0386	Belongs to the glutathione peroxidase family
SHL15_RS16245	COG1686	Belongs to the peptidase S11 family
SHL15_RS16285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHL15_RS16305	COG3629	intracellular signal transduction
SHL15_RS16305	COG3903	Transcriptional regulator
SHL15_RS16340	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS16350	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHL15_RS16350	COG0515	serine threonine protein kinase
SHL15_RS16370	COG0259	pyridoxamine-phosphate oxidase activity
SHL15_RS16380	COG2072	flavoprotein involved in K transport
SHL15_RS16420	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS16465	COG0596	Alpha beta hydrolase
SHL15_RS16465	COG2945	thiolester hydrolase activity
SHL15_RS16475	COG4821	SIS domain
SHL15_RS16490	COG0259	pyridoxamine-phosphate oxidase activity
SHL15_RS16505	COG1309	transcriptional regulator
SHL15_RS16515	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS16525	COG4770	biotin carboxylase activity
SHL15_RS16530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHL15_RS16545	COG0281	malic enzyme
SHL15_RS16550	COG5006	permease, DMT superfamily
SHL15_RS16570	COG0247	lactate metabolic process
SHL15_RS16570	COG0277	FAD linked oxidase domain protein
SHL15_RS16575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SHL15_RS16595	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS16600	COG0667	Aldo Keto reductase
SHL15_RS16630	COG2252	PERMEase
SHL15_RS16640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SHL15_RS16670	COG2326	polyphosphate kinase activity
SHL15_RS16695	COG2814	Major facilitator Superfamily
SHL15_RS16705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHL15_RS16710	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHL15_RS16715	COG1278	Cold shock
SHL15_RS16755	COG1061	Type III restriction enzyme res subunit
SHL15_RS16760	COG1231	oxidoreductase activity
SHL15_RS16780	COG3973	AAA domain
SHL15_RS16800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHL15_RS16815	COG1737	Transcriptional regulator
SHL15_RS16820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SHL15_RS16835	COG0459	protein refolding
SHL15_RS16840	COG1278	Cold shock
SHL15_RS16855	COG0463	Glycosyl transferase, family 2
SHL15_RS16885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SHL15_RS16900	COG5001	Diguanylate cyclase
SHL15_RS16900	COG3300	MHYT domain
SHL15_RS16920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SHL15_RS16980	COG3842	ATPase activity
SHL15_RS17005	COG0215	cysteine-tRNA ligase activity
SHL15_RS17015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SHL15_RS17020	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SHL15_RS17025	COG1329	Transcriptional regulator
SHL15_RS17040	COG5002	protein histidine kinase activity
SHL15_RS17070	COG0588	phosphoglycerate mutase activity
SHL15_RS17155	COG0438	transferase activity, transferring glycosyl groups
SHL15_RS17190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SHL15_RS17205	COG1309	transcriptional regulator
SHL15_RS17220	COG2186	Transcriptional regulator
SHL15_RS17230	COG2188	Transcriptional regulator
SHL15_RS17240	COG1490	D-aminoacyl-tRNA deacylase activity
SHL15_RS17260	COG2897	thiosulfate sulfurtransferase activity
SHL15_RS17280	COG3485	protocatechuate 3,4-dioxygenase
SHL15_RS17290	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SHL15_RS17305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SHL15_RS17330	COG0745	RESPONSE REGULATOR receiver
SHL15_RS17335	COG1609	Transcriptional regulator
SHL15_RS17340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHL15_RS17350	COG0745	RESPONSE REGULATOR receiver
SHL15_RS17360	COG1846	Transcriptional regulator
SHL15_RS17370	COG0737	Belongs to the 5'-nucleotidase family
SHL15_RS17375	COG0456	acetyltransferase
SHL15_RS17380	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SHL15_RS17390	COG0406	alpha-ribazole phosphatase activity
SHL15_RS17390	COG0494	nUDIX hydrolase
SHL15_RS17405	COG1937	Protein conserved in bacteria
SHL15_RS17415	COG0306	phosphate transporter
SHL15_RS17420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SHL15_RS17435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SHL15_RS17440	COG0277	FAD linked oxidase domain protein
SHL15_RS17445	COG0671	phosphoesterase, PA-phosphatase related
SHL15_RS17535	COG1252	NADH dehydrogenase
SHL15_RS17565	COG0579	oxidoreductase
SHL15_RS17570	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SHL15_RS17580	COG0667	Aldo Keto reductase
SHL15_RS17600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHL15_RS17600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHL15_RS17610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHL15_RS17615	COG0477	Major facilitator Superfamily
SHL15_RS17645	COG0513	Belongs to the DEAD box helicase family
SHL15_RS17690	COG1643	Atp-dependent helicase
SHL15_RS17725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SHL15_RS17755	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHL15_RS17760	COG0047	phosphoribosylformylglycinamidine synthase activity
SHL15_RS17765	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SHL15_RS17790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SHL15_RS17805	COG0151	Belongs to the GarS family
SHL15_RS17835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHL15_RS17840	COG0798	PFAM Bile acid sodium symporter
SHL15_RS17845	COG0640	Transcriptional regulator
SHL15_RS17860	COG1276	copper resistance
SHL15_RS17860	COG2372	response to copper ion
SHL15_RS17875	COG1132	(ABC) transporter
SHL15_RS17875	COG2375	cellular response to nickel ion
SHL15_RS17895	COG0433	COG0433 Predicted ATPase
SHL15_RS17910	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SHL15_RS17945	COG1191	sigma factor activity
SHL15_RS17950	COG1191	sigma factor activity
SHL15_RS17965	COG0477	Major facilitator Superfamily
SHL15_RS17970	COG2353	YceI-like domain
SHL15_RS17975	COG3467	pyridoxamine 5'-phosphate
SHL15_RS17985	COG0477	Major facilitator Superfamily
SHL15_RS17990	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SHL15_RS18000	COG2205	protein histidine kinase activity
SHL15_RS18005	COG0745	RESPONSE REGULATOR receiver
SHL15_RS18025	COG1846	Transcriptional regulator
SHL15_RS18070	COG0784	Response regulator, receiver
SHL15_RS18075	COG1309	transcriptional regulator
SHL15_RS18080	COG2814	Major facilitator Superfamily
SHL15_RS18085	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS18090	COG1595	DNA-templated transcription, initiation
SHL15_RS18120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHL15_RS18135	COG0653	protein targeting
SHL15_RS18155	COG0006	proline dipeptidase activity
SHL15_RS18160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHL15_RS18195	COG2837	iron assimilation
SHL15_RS18205	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SHL15_RS18210	COG0561	phosphatase activity
SHL15_RS18235	COG1131	(ABC) transporter
SHL15_RS18250	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SHL15_RS18260	COG0561	phosphatase activity
SHL15_RS18265	COG4988	ABC transporter
SHL15_RS18270	COG1294	oxidase, subunit
SHL15_RS18275	COG1271	oxidase subunit
SHL15_RS18280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SHL15_RS18285	COG1609	Transcriptional regulator
SHL15_RS18300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SHL15_RS18315	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SHL15_RS18340	COG0662	Cupin 2, conserved barrel domain protein
SHL15_RS18345	COG1950	PFAM Membrane protein of
SHL15_RS18350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHL15_RS18355	COG0626	cystathionine gamma-synthase activity
SHL15_RS18390	COG2814	Major facilitator Superfamily
SHL15_RS18410	COG0305	Participates in initiation and elongation during chromosome replication
SHL15_RS18420	COG0359	binds to the 23S rRNA
SHL15_RS18425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHL15_RS18430	COG0629	single-stranded DNA binding
SHL15_RS18435	COG0360	Binds together with S18 to 16S ribosomal RNA
SHL15_RS18460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHL15_RS18480	COG0617	tRNA 3'-terminal CCA addition
SHL15_RS18495	COG0515	serine threonine protein kinase
SHL15_RS18495	COG2815	serine threonine protein kinase
SHL15_RS18500	COG1595	DNA-templated transcription, initiation
SHL15_RS18510	COG0492	ferredoxin-NADP+ reductase activity
SHL15_RS18515	COG3118	belongs to the thioredoxin family
SHL15_RS18530	COG1192	Involved in chromosome partitioning
SHL15_RS18535	COG0357	Ribosomal RNA small subunit methyltransferase G
SHL15_RS18545	COG0706	membrane insertase activity
SHL15_RS18550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SHL15_RS18565	COG0592	DNA-directed DNA polymerase activity
SHL15_RS18570	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SHL15_RS18575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SHL15_RS18580	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SHL15_RS18585	COG0187	DNA topoisomerase II activity
SHL15_RS18590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SHL15_RS18605	COG4249	Peptidase C14 caspase catalytic subunit p20
SHL15_RS18605	COG2319	Wd-40 repeat
SHL15_RS18605	COG4249	Peptidase C14 caspase catalytic subunit p20
SHL15_RS18605	COG2319	Wd-40 repeat
SHL15_RS18630	COG0515	serine threonine protein kinase
SHL15_RS18655	COG0705	Rhomboid family
SHL15_RS18675	COG3764	Sortase (surface protein transpeptidase)
SHL15_RS18680	COG3764	Sortase (surface protein transpeptidase)
SHL15_RS18685	COG0515	serine threonine protein kinase
SHL15_RS18690	COG0768	penicillin binding
SHL15_RS18705	COG1716	ATPase activity
SHL15_RS18710	COG1716	ATPase activity
SHL15_RS18750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SHL15_RS18755	COG2151	metal-sulfur cluster biosynthetic enzyme
SHL15_RS18760	COG3396	Phenylacetate-CoA oxygenase
SHL15_RS18765	COG3460	Phenylacetate-CoA oxygenase
SHL15_RS18770	COG3396	Phenylacetate-CoA oxygenase
SHL15_RS18795	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHL15_RS18800	COG1309	transcriptional regulator
SHL15_RS18805	COG1522	sequence-specific DNA binding
SHL15_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS18840	COG0604	alcohol dehydrogenase
SHL15_RS18840	COG3321	synthase
SHL15_RS18855	COG0515	serine threonine protein kinase
SHL15_RS18860	COG0515	serine threonine protein kinase
SHL15_RS18875	COG0022	dehydrogenase e1 component
SHL15_RS18880	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHL15_RS18950	COG1362	aminopeptidase activity
SHL15_RS18955	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS18970	COG1741	Belongs to the pirin family
SHL15_RS18985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SHL15_RS18995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHL15_RS19005	COG1289	transmembrane transporter activity
SHL15_RS19065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHL15_RS19070	COG1957	nucleoside hydrolase
SHL15_RS19080	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SHL15_RS19085	COG0640	Transcriptional regulator
SHL15_RS19090	COG0366	Alpha amylase catalytic
SHL15_RS19130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SHL15_RS19135	COG1595	DNA-templated transcription, initiation
SHL15_RS19150	COG0513	Belongs to the DEAD box helicase family
SHL15_RS19155	COG1278	Cold shock
SHL15_RS19165	COG2197	response regulator
SHL15_RS19170	COG4585	Histidine kinase
SHL15_RS19185	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS19200	COG0477	Major facilitator Superfamily
SHL15_RS19215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHL15_RS19220	COG0531	amino acid
SHL15_RS19225	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHL15_RS19230	COG1191	sigma factor activity
SHL15_RS19270	COG2815	serine threonine protein kinase
SHL15_RS19270	COG0515	serine threonine protein kinase
SHL15_RS19300	COG0142	geranyltranstransferase activity
SHL15_RS19345	COG2188	Transcriptional regulator
SHL15_RS19355	COG2188	Transcriptional regulator
SHL15_RS19420	COG0717	Belongs to the dCTP deaminase family
SHL15_RS19425	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SHL15_RS19455	COG0247	lactate metabolic process
SHL15_RS19455	COG2181	nitrate reductase activity
SHL15_RS19460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHL15_RS19465	COG0443	Heat shock 70 kDa protein
SHL15_RS19470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHL15_RS19475	COG0484	heat shock protein binding
SHL15_RS19480	COG0789	Transcriptional regulator
SHL15_RS19485	COG4213	ABC transporter substrate-binding protein
SHL15_RS19515	COG0542	response to heat
SHL15_RS19540	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SHL15_RS19555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SHL15_RS19565	COG0477	Major facilitator Superfamily
SHL15_RS19580	COG3483	tryptophan 2,3-dioxygenase activity
SHL15_RS19585	COG3844	kynureninase activity
SHL15_RS19595	COG4585	Histidine kinase
SHL15_RS19600	COG2197	response regulator
SHL15_RS19620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SHL15_RS19630	COG1802	Transcriptional regulator
SHL15_RS19635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHL15_RS19655	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SHL15_RS19660	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SHL15_RS19725	COG0701	Predicted permease
SHL15_RS19800	COG3629	intracellular signal transduction
SHL15_RS19800	COG3903	Transcriptional regulator
SHL15_RS19880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHL15_RS19900	COG0556	nucleotide-excision repair
SHL15_RS19920	COG0017	Asparaginyl-tRNA synthetase
SHL15_RS19925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHL15_RS19935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SHL15_RS19940	COG2192	nodulation
SHL15_RS19955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHL15_RS19965	COG0297	glycogen (starch) synthase activity
SHL15_RS20040	COG1609	Transcriptional regulator
SHL15_RS20065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SHL15_RS20085	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHL15_RS20105	COG1324	tolerance protein
SHL15_RS20165	COG1609	Transcriptional regulator
SHL15_RS20195	COG1408	metallophosphoesterase
SHL15_RS20205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHL15_RS20215	COG0003	Pfam Anion-transporting ATPase
SHL15_RS20235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHL15_RS20265	COG2267	carboxylic ester hydrolase activity
SHL15_RS20280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHL15_RS20285	COG0659	secondary active sulfate transmembrane transporter activity
SHL15_RS20340	COG1205	dead DEAH box helicase
SHL15_RS20340	COG1111	helicase
SHL15_RS20345	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS20355	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SHL15_RS20375	COG1754	DNA topoisomerase type I activity
SHL15_RS20375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SHL15_RS20380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SHL15_RS20405	COG3629	intracellular signal transduction
SHL15_RS20405	COG3903	Transcriptional regulator
SHL15_RS20410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHL15_RS20410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SHL15_RS20465	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS20470	COG2318	DinB family
SHL15_RS20480	COG0076	glutamate decarboxylase activity
SHL15_RS20490	COG0789	Transcriptional regulator
SHL15_RS20505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SHL15_RS20510	COG2027	D-alanyl-D-alanine carboxypeptidase
SHL15_RS20520	COG0037	tRNA processing
SHL15_RS20535	COG0302	gtp cyclohydrolase
SHL15_RS20550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SHL15_RS20565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SHL15_RS20565	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SHL15_RS20590	COG0649	NAD binding
SHL15_RS20605	COG2197	response regulator
SHL15_RS20630	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SHL15_RS20635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SHL15_RS20645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SHL15_RS20665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SHL15_RS20690	COG0739	heme binding
SHL15_RS20710	COG2205	protein histidine kinase activity
SHL15_RS20715	COG0745	RESPONSE REGULATOR receiver
SHL15_RS20725	COG1595	DNA-templated transcription, initiation
SHL15_RS20740	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SHL15_RS20760	COG0248	Ppx GppA phosphatase
SHL15_RS20765	COG1082	Xylose isomerase domain protein TIM barrel
SHL15_RS20770	COG1309	transcriptional regulator
SHL15_RS20775	COG0129	dihydroxy-acid dehydratase activity
SHL15_RS20780	COG3547	Transposase (IS116 IS110 IS902 family)
SHL15_RS20785	COG0515	serine threonine protein kinase
SHL15_RS20785	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHL15_RS20790	COG4991	sh3 domain protein
SHL15_RS20805	COG1129	ABC transporter
SHL15_RS20805	COG0842	Transport permease protein
SHL15_RS20815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SHL15_RS20820	COG0180	Tryptophanyl-tRNA synthetase
SHL15_RS20840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHL15_RS20850	COG2223	nitrite transmembrane transporter activity
SHL15_RS20855	COG0123	including yeast histone deacetylase and acetoin utilization protein
SHL15_RS20900	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SHL15_RS20905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SHL15_RS20910	COG0181	hydroxymethylbilane synthase activity
SHL15_RS20915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SHL15_RS20915	COG1648	precorrin-2 dehydrogenase activity
SHL15_RS20920	COG0113	porphobilinogen synthase activity
SHL15_RS20960	COG3629	intracellular signal transduction
SHL15_RS20960	COG3903	Transcriptional regulator
SHL15_RS20965	COG0018	arginyl-trna synthetase
SHL15_RS20970	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SHL15_RS20990	COG1690	Belongs to the RtcB family
SHL15_RS21005	COG0702	epimerase
SHL15_RS21015	COG1742	UPF0060 membrane protein
SHL15_RS21020	COG1733	regulation of RNA biosynthetic process
SHL15_RS21030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS21035	COG0431	NADPH-dependent FMN reductase
SHL15_RS21045	COG2205	protein histidine kinase activity
SHL15_RS21055	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SHL15_RS21055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SHL15_RS21065	COG2362	D-Aminopeptidase
SHL15_RS21095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SHL15_RS21140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SHL15_RS21145	COG0297	glycogen (starch) synthase activity
SHL15_RS21150	COG0717	Belongs to the dCTP deaminase family
SHL15_RS21165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHL15_RS21215	COG0582	viral genome integration into host DNA
SHL15_RS21225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SHL15_RS21230	COG0406	alpha-ribazole phosphatase activity
SHL15_RS21245	COG0785	Cytochrome C biogenesis protein
SHL15_RS21250	COG1333	cytochrome c biogenesis protein
SHL15_RS21255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SHL15_RS21275	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SHL15_RS21285	COG0163	prenyltransferase activity
SHL15_RS21295	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHL15_RS21300	COG1573	uracil-dna glycosylase
SHL15_RS21315	COG1309	transcriptional regulator
SHL15_RS21330	COG0583	DNA-binding transcription factor activity
SHL15_RS21350	COG2226	methyltransferase
SHL15_RS21355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SHL15_RS21355	COG0515	serine threonine protein kinase
SHL15_RS21375	COG1278	Cold shock
SHL15_RS21380	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SHL15_RS21390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SHL15_RS21400	COG3979	chitinase
SHL15_RS21420	COG2226	methyltransferase
SHL15_RS21440	COG0242	peptide deformylase activity
SHL15_RS21455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21465	COG0649	NAD binding
SHL15_RS21475	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SHL15_RS21480	COG1034	ATP synthesis coupled electron transport
SHL15_RS21485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHL15_RS21490	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21495	COG0839	Belongs to the complex I subunit 6 family
SHL15_RS21500	COG0713	ATP synthesis coupled electron transport
SHL15_RS21505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SHL15_RS21515	COG1007	ATP synthesis coupled electron transport
SHL15_RS21520	COG0514	ATP-dependent DNA helicase (RecQ)
SHL15_RS21535	COG0561	phosphatase activity
SHL15_RS21540	COG5280	Phage tail tape measure protein TP901
SHL15_RS21540	COG3953	SLT domain
SHL15_RS21545	COG0142	geranyltranstransferase activity
SHL15_RS21555	COG1131	(ABC) transporter
SHL15_RS21585	COG0702	epimerase
SHL15_RS21590	COG1733	regulation of RNA biosynthetic process
SHL15_RS21595	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHL15_RS21600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SHL15_RS21600	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHL15_RS21620	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21625	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHL15_RS21640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21645	COG0839	Belongs to the complex I subunit 6 family
SHL15_RS21650	COG0713	ATP synthesis coupled electron transport
SHL15_RS21660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS21665	COG1007	ATP synthesis coupled electron transport
SHL15_RS21670	COG0501	Belongs to the peptidase M48B family
SHL15_RS21680	COG1672	PFAM Archaeal ATPase
SHL15_RS21680	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SHL15_RS21705	COG2261	transglycosylase associated protein
SHL15_RS21710	COG1666	GTP binding
SHL15_RS21735	COG0702	epimerase
SHL15_RS21755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SHL15_RS21760	COG2030	dehydratase
SHL15_RS21775	COG0477	Major facilitator Superfamily
SHL15_RS21785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SHL15_RS21805	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHL15_RS21810	COG0436	Aminotransferase
SHL15_RS21825	COG0250	Participates in transcription elongation, termination and antitermination
SHL15_RS21835	COG0081	regulation of translation
SHL15_RS21855	COG0085	RNA polymerase activity
SHL15_RS21860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SHL15_RS21895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SHL15_RS21900	COG0049	tRNA binding
SHL15_RS21905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SHL15_RS21925	COG0051	transcription antitermination factor activity, RNA binding
SHL15_RS21930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SHL15_RS21935	COG0088	Forms part of the polypeptide exit tunnel
SHL15_RS21940	COG0089	rRNA binding
SHL15_RS21945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SHL15_RS21950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SHL15_RS21955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SHL15_RS21960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SHL15_RS21965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SHL15_RS21970	COG0255	Belongs to the universal ribosomal protein uL29 family
SHL15_RS21975	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SHL15_RS21980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SHL15_RS21985	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SHL15_RS21990	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SHL15_RS21995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SHL15_RS22000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SHL15_RS22005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SHL15_RS22010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SHL15_RS22015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SHL15_RS22020	COG1841	ribosomal large subunit assembly
SHL15_RS22025	COG0200	Binds to the 23S rRNA
SHL15_RS22035	COG0563	adenylate kinase activity
SHL15_RS22045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SHL15_RS22050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SHL15_RS22055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SHL15_RS22060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SHL15_RS22065	COG0202	RNA polymerase activity
SHL15_RS22070	COG0203	ribosomal protein L17
SHL15_RS22075	COG0101	tRNA pseudouridine synthase activity
SHL15_RS22095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SHL15_RS22110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SHL15_RS22115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SHL15_RS22120	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHL15_RS22130	COG1072	(Pantothenic acid kinase))
SHL15_RS22135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHL15_RS22140	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS22145	COG0736	holo-[acyl-carrier-protein] synthase activity
SHL15_RS22155	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SHL15_RS22165	COG0802	atpase or kinase
SHL15_RS22190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SHL15_RS22205	COG1609	Transcriptional regulator
SHL15_RS22220	COG4941	Belongs to the sigma-70 factor family
SHL15_RS22230	COG0726	polysaccharide deacetylase
SHL15_RS22235	COG0726	polysaccharide deacetylase
SHL15_RS22245	COG0459	protein refolding
SHL15_RS22250	COG1201	RNA secondary structure unwinding
SHL15_RS22335	COG4221	oxidoreductase activity
SHL15_RS22345	COG0583	DNA-binding transcription factor activity
SHL15_RS22355	COG2197	response regulator
SHL15_RS22360	COG1595	DNA-templated transcription, initiation
SHL15_RS22370	COG0516	GMP reductase activity
SHL15_RS22380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHL15_RS22390	COG2815	serine threonine protein kinase
SHL15_RS22390	COG0515	serine threonine protein kinase
SHL15_RS22395	COG0515	serine threonine protein kinase
SHL15_RS22400	COG2815	serine threonine protein kinase
SHL15_RS22400	COG0515	serine threonine protein kinase
SHL15_RS22415	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS22430	COG0519	Catalyzes the synthesis of GMP from XMP
SHL15_RS22430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SHL15_RS22485	COG2197	response regulator
SHL15_RS22500	COG0791	NLP P60 protein
SHL15_RS22510	COG0739	heme binding
SHL15_RS22520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS22520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS22535	COG0714	Associated with various cellular activities
SHL15_RS22540	COG2425	protein containing a von Willebrand factor type A (vWA) domain
SHL15_RS22550	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SHL15_RS22555	COG0045	succinate-CoA ligase (ADP-forming) activity
SHL15_RS22585	COG0138	bifunctional purine biosynthesis protein purh
SHL15_RS22590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHL15_RS22605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SHL15_RS22630	COG2409	Drug exporters of the RND superfamily
SHL15_RS22640	COG3903	Transcriptional regulator
SHL15_RS22640	COG3629	intracellular signal transduction
SHL15_RS22645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHL15_RS22650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHL15_RS22655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHL15_RS22660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHL15_RS22685	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SHL15_RS22730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SHL15_RS22740	COG4585	Histidine kinase
SHL15_RS22745	COG2197	response regulator
SHL15_RS22755	COG0039	L-malate dehydrogenase activity
SHL15_RS22770	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS22780	COG4175	Glycine betaine
SHL15_RS22780	COG0517	IMP dehydrogenase activity
SHL15_RS22785	COG4176	ABC-type proline glycine betaine transport system permease component
SHL15_RS22800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS22805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHL15_RS22820	COG0754	glutathionylspermidine amidase activity
SHL15_RS22835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHL15_RS22840	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHL15_RS22845	COG0180	Tryptophanyl-tRNA synthetase
SHL15_RS22860	COG1295	ribonuclease BN
SHL15_RS22875	COG1408	metallophosphoesterase
SHL15_RS22890	COG1309	transcriptional regulator
SHL15_RS22905	COG1053	succinate dehydrogenase
SHL15_RS22915	COG2009	succinate dehydrogenase
SHL15_RS22925	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SHL15_RS22955	COG1595	DNA-templated transcription, initiation
SHL15_RS22970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS22970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS22990	COG1216	Glycosyl transferase, family 2
SHL15_RS23005	COG2089	acid synthase
SHL15_RS23025	COG1473	amidohydrolase
SHL15_RS23025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SHL15_RS23030	COG1744	ABC transporter substrate-binding protein PnrA-like
SHL15_RS23035	COG3845	ABC transporter
SHL15_RS23040	COG4603	Belongs to the binding-protein-dependent transport system permease family
SHL15_RS23045	COG1079	Belongs to the binding-protein-dependent transport system permease family
SHL15_RS23070	COG2814	Major facilitator Superfamily
SHL15_RS23075	COG0583	DNA-binding transcription factor activity
SHL15_RS23085	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHL15_RS23110	COG2205	protein histidine kinase activity
SHL15_RS23115	COG0745	RESPONSE REGULATOR receiver
SHL15_RS23120	COG1595	DNA-templated transcription, initiation
SHL15_RS23135	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS23140	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS23145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SHL15_RS23160	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHL15_RS23180	COG1349	DNA-binding transcription factor activity
SHL15_RS23185	COG4770	biotin carboxylase activity
SHL15_RS23195	COG0424	maF-like protein
SHL15_RS23205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHL15_RS23215	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SHL15_RS23225	COG1024	Enoyl-CoA hydratase
SHL15_RS23235	COG2986	histidine ammonia-lyase
SHL15_RS23265	COG1136	(ABC) transporter
SHL15_RS23270	COG1404	Belongs to the peptidase S8 family
SHL15_RS23280	COG1064	alcohol dehydrogenase
SHL15_RS23290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHL15_RS23300	COG0501	Belongs to the peptidase M48B family
SHL15_RS23320	COG1595	DNA-templated transcription, initiation
SHL15_RS23325	COG2255	four-way junction helicase activity
SHL15_RS23330	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SHL15_RS23345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SHL15_RS23355	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHL15_RS23370	COG1331	Highly conserved protein containing a thioredoxin domain
SHL15_RS23380	COG1309	transcriptional regulator
SHL15_RS23390	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SHL15_RS23425	COG0436	Aminotransferase
SHL15_RS23440	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SHL15_RS23455	COG1414	Transcriptional regulator
SHL15_RS23465	COG2610	gluconate transmembrane transporter activity
SHL15_RS23505	COG3209	COG3209 Rhs family protein
SHL15_RS23535	COG2894	cell division
SHL15_RS23565	COG3920	Histidine kinase
SHL15_RS23610	COG2226	methyltransferase
SHL15_RS23615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHL15_RS23620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SHL15_RS23625	COG0741	lytic transglycosylase activity
SHL15_RS23635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS23640	COG0450	alkyl hydroperoxide reductase
SHL15_RS23655	COG1136	(ABC) transporter
SHL15_RS23675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SHL15_RS23690	COG0114	fumarate hydratase activity
SHL15_RS23695	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SHL15_RS23695	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SHL15_RS23720	COG0778	Nitroreductase
SHL15_RS23725	COG1722	exodeoxyribonuclease VII activity
SHL15_RS23730	COG1570	exodeoxyribonuclease VII activity
SHL15_RS23740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SHL15_RS23755	COG0012	GTP binding
SHL15_RS23790	COG3547	Transposase (IS116 IS110 IS902 family)
SHL15_RS23795	COG0592	DNA-directed DNA polymerase activity
SHL15_RS23805	COG1834	amidinotransferase
SHL15_RS23840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHL15_RS23840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHL15_RS23850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SHL15_RS23865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SHL15_RS23875	COG3629	intracellular signal transduction
SHL15_RS23875	COG3903	Transcriptional regulator
SHL15_RS23880	COG3903	Transcriptional regulator
SHL15_RS23880	COG3629	intracellular signal transduction
SHL15_RS23935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHL15_RS23940	COG1053	succinate dehydrogenase
SHL15_RS23960	COG1217	gtp-binding protein TYPA
SHL15_RS23965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHL15_RS23970	COG4166	transmembrane transport
SHL15_RS23975	COG0601	transmembrane transport
SHL15_RS23980	COG0444	Belongs to the ABC transporter superfamily
SHL15_RS23985	COG4608	Belongs to the ABC transporter superfamily
SHL15_RS23995	COG4608	Belongs to the ABC transporter superfamily
SHL15_RS24000	COG0444	Belongs to the ABC transporter superfamily
SHL15_RS24005	COG0601	transmembrane transport
SHL15_RS24010	COG4166	transmembrane transport
SHL15_RS24015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHL15_RS24025	COG0601	transmembrane transport
SHL15_RS24030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHL15_RS24040	COG4608	Belongs to the ABC transporter superfamily
SHL15_RS24055	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
SHL15_RS24060	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SHL15_RS24075	COG4249	Peptidase C14 caspase catalytic subunit p20
SHL15_RS24075	COG2319	Wd-40 repeat
SHL15_RS24100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHL15_RS24115	COG1131	(ABC) transporter
SHL15_RS24125	COG4585	Histidine kinase
SHL15_RS24130	COG2197	response regulator
SHL15_RS24140	COG1214	PFAM Peptidase M22, glycoprotease
SHL15_RS24140	COG0456	acetyltransferase
SHL15_RS24165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHL15_RS24170	COG1611	Belongs to the LOG family
SHL15_RS24175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SHL15_RS24185	COG0519	Catalyzes the synthesis of GMP from XMP
SHL15_RS24190	COG1024	Enoyl-CoA hydratase
SHL15_RS24200	COG1595	DNA-templated transcription, initiation
SHL15_RS24210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHL15_RS24215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SHL15_RS24260	COG0598	Magnesium transport protein CorA
SHL15_RS24270	COG2814	Major facilitator Superfamily
SHL15_RS24285	COG2095	MarC family integral membrane protein
SHL15_RS24290	COG1432	Conserved Protein
SHL15_RS24345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHL15_RS24415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHL15_RS24420	COG2816	NAD+ diphosphatase activity
SHL15_RS24445	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SHL15_RS24495	COG3480	Lon protease (S16) C-terminal proteolytic domain
SHL15_RS24505	COG1615	UPF0182 protein
SHL15_RS24530	COG0753	catalase activity
SHL15_RS24540	COG0483	inositol monophosphate 1-phosphatase activity
SHL15_RS24555	COG2076	Multidrug Resistance protein
SHL15_RS24565	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SHL15_RS24575	COG2135	peptidase activity
SHL15_RS24585	COG1595	DNA-templated transcription, initiation
SHL15_RS24590	COG5662	AntiSigma factor
SHL15_RS24595	COG2199	diguanylate cyclase activity
SHL15_RS24595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SHL15_RS24610	COG0242	peptide deformylase activity
SHL15_RS24620	COG2124	cytochrome p450
SHL15_RS24640	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHL15_RS24670	COG2188	Transcriptional regulator
SHL15_RS24675	COG0363	glucosamine-6-phosphate deaminase activity
SHL15_RS24680	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS24700	COG1597	lipid kinase activity
SHL15_RS24715	COG2172	sigma factor antagonist activity
SHL15_RS24730	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SHL15_RS24740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SHL15_RS24745	COG0142	geranyltranstransferase activity
SHL15_RS24800	COG4106	trans-aconitate 2-methyltransferase activity
SHL15_RS24805	COG1126	abc transporter atp-binding protein
SHL15_RS24820	COG0281	malic enzyme
SHL15_RS24825	COG0604	alcohol dehydrogenase
SHL15_RS24865	COG2255	four-way junction helicase activity
SHL15_RS24890	COG0508	dehydrogenase complex catalyzes the overall conversion of
SHL15_RS24890	COG0567	Dehydrogenase, E1 component
SHL15_RS24895	COG2205	protein histidine kinase activity
SHL15_RS24900	COG0745	RESPONSE REGULATOR receiver
SHL15_RS24915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SHL15_RS24995	COG0768	penicillin binding
SHL15_RS25000	COG0772	Belongs to the SEDS family
SHL15_RS25005	COG2205	protein histidine kinase activity
SHL15_RS25025	COG3285	dna ligase
SHL15_RS25025	COG1793	dna ligase
SHL15_RS25030	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SHL15_RS25055	COG0018	arginyl-trna synthetase
SHL15_RS25060	COG0019	diaminopimelate decarboxylase activity
SHL15_RS25065	COG0460	homoserine dehydrogenase
SHL15_RS25070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SHL15_RS25075	COG0083	homoserine kinase activity
SHL15_RS25090	COG0254	rRNA binding
SHL15_RS25095	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SHL15_RS25100	COG2890	protein-(glutamine-N5) methyltransferase activity
SHL15_RS25110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHL15_RS25115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHL15_RS25120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHL15_RS25135	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHL15_RS25140	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SHL15_RS25145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SHL15_RS25150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SHL15_RS25155	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SHL15_RS25160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SHL15_RS25165	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SHL15_RS25180	COG2197	response regulator
SHL15_RS25185	COG4585	Histidine kinase
SHL15_RS25195	COG2318	DinB family
SHL15_RS25205	COG0667	Aldo Keto reductase
SHL15_RS25210	COG1309	transcriptional regulator
SHL15_RS25230	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHL15_RS25245	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SHL15_RS25305	COG0183	Belongs to the thiolase family
SHL15_RS25375	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS25375	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS25410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SHL15_RS25415	COG0857	belongs to the CobB CobQ family
SHL15_RS25415	COG0280	phosphate acetyltransferase
SHL15_RS25420	COG0205	6-phosphofructokinase activity
SHL15_RS25425	COG0395	ABC-type sugar transport system, permease component
SHL15_RS25430	COG1175	transmembrane transport
SHL15_RS25460	COG4565	transcriptional regulatory protein
SHL15_RS25465	COG3290	protein histidine kinase activity
SHL15_RS25470	COG1301	dicarboxylic acid transport
SHL15_RS25480	COG0477	Major facilitator Superfamily
SHL15_RS25500	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SHL15_RS25505	COG3281	Trehalose synthase
SHL15_RS25515	COG0366	Alpha amylase catalytic
SHL15_RS25520	COG0058	SHG alpha-glucan phosphorylase activity
SHL15_RS25540	COG1132	(ABC) transporter
SHL15_RS25545	COG1132	(ABC) transporter
SHL15_RS25550	COG1132	(ABC) transporter
SHL15_RS25555	COG1132	(ABC) transporter
SHL15_RS25585	COG1376	ErfK ybiS ycfS ynhG family protein
SHL15_RS25590	COG1376	ErfK ybiS ycfS ynhG family protein
SHL15_RS25630	COG1119	ATPase activity
SHL15_RS25635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHL15_RS25645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SHL15_RS25650	COG3409	Peptidoglycan-binding domain 1 protein
SHL15_RS25650	COG3757	hydrolase, family 25
SHL15_RS25665	COG1760	l-serine dehydratase
SHL15_RS25670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHL15_RS25675	COG0509	glycine decarboxylation via glycine cleavage system
SHL15_RS25680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SHL15_RS25700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHL15_RS25705	COG0747	negative chemotaxis
SHL15_RS25715	COG0444	Belongs to the ABC transporter superfamily
SHL15_RS25720	COG4608	Belongs to the ABC transporter superfamily
SHL15_RS25730	COG2860	membrane
SHL15_RS25750	COG2378	regulation of single-species biofilm formation
SHL15_RS25775	COG0482	sulfurtransferase activity
SHL15_RS25790	COG1611	Belongs to the LOG family
SHL15_RS25795	COG4221	oxidoreductase activity
SHL15_RS25805	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SHL15_RS25830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHL15_RS25835	COG0154	amidase activity
SHL15_RS25845	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHL15_RS25860	COG2409	Drug exporters of the RND superfamily
SHL15_RS25865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHL15_RS25880	COG2197	response regulator
SHL15_RS25890	COG2133	pyrroloquinoline quinone binding
SHL15_RS25895	COG0667	Aldo Keto reductase
SHL15_RS25905	COG5001	Diguanylate cyclase
SHL15_RS25915	COG0440	acetolactate synthase activity
SHL15_RS25920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SHL15_RS25930	COG0477	Major facilitator Superfamily
SHL15_RS25940	COG2508	Transcriptional regulator
SHL15_RS25945	COG0506	proline dehydrogenase activity
SHL15_RS25950	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS25955	COG2267	carboxylic ester hydrolase activity
SHL15_RS25965	COG2130	NADP-dependent
SHL15_RS25970	COG0583	DNA-binding transcription factor activity
SHL15_RS25980	COG0473	3-isopropylmalate dehydrogenase activity
SHL15_RS25985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SHL15_RS25990	COG0832	Belongs to the urease beta subunit family
SHL15_RS25990	COG0831	urea catabolic process
SHL15_RS25995	COG0804	urea catabolic process
SHL15_RS26000	COG2957	Belongs to the agmatine deiminase family
SHL15_RS26010	COG0477	Major facilitator Superfamily
SHL15_RS26015	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SHL15_RS26065	COG2353	YceI-like domain
SHL15_RS26075	COG5492	domain, Protein
SHL15_RS26080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SHL15_RS26105	COG2018	Roadblock/LC7 domain
SHL15_RS26125	COG2018	Roadblock/LC7 domain
SHL15_RS26130	COG5002	protein histidine kinase activity
SHL15_RS26140	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHL15_RS26145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHL15_RS26195	COG1414	Transcriptional regulator
SHL15_RS26200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SHL15_RS26205	COG0066	3-isopropylmalate dehydratase activity
SHL15_RS26215	COG0776	regulation of translation
SHL15_RS26225	COG1920	GTP binding
SHL15_RS26235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SHL15_RS26240	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHL15_RS26260	COG0351	phosphomethylpyrimidine kinase
SHL15_RS26270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SHL15_RS26275	COG1461	Dihydroxyacetone kinase
SHL15_RS26285	COG0326	Molecular chaperone. Has ATPase activity
SHL15_RS26295	COG0742	ribosomal rna small subunit methyltransferase
SHL15_RS26300	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SHL15_RS26315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SHL15_RS26320	COG0571	ribonuclease III activity
SHL15_RS26325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHL15_RS26330	COG1733	regulation of RNA biosynthetic process
SHL15_RS26335	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHL15_RS26345	COG1254	Belongs to the acylphosphatase family
SHL15_RS26355	COG1196	nuclear chromosome segregation
SHL15_RS26360	COG0477	Major facilitator Superfamily
SHL15_RS26400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SHL15_RS26410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHL15_RS26425	COG0228	four-way junction DNA binding
SHL15_RS26430	COG1837	Belongs to the UPF0109 family
SHL15_RS26435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SHL15_RS26440	COG0336	Belongs to the RNA methyltransferase TrmD family
SHL15_RS26445	COG0335	large ribosomal subunit rRNA binding
SHL15_RS26460	COG0681	Belongs to the peptidase S26 family
SHL15_RS26480	COG0792	nuclease activity
SHL15_RS26495	COG1191	sigma factor activity
SHL15_RS26510	COG0052	Belongs to the universal ribosomal protein uS2 family
SHL15_RS26515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SHL15_RS26520	COG0528	UMP kinase activity
SHL15_RS26525	COG0233	cytoplasmic translational termination
SHL15_RS26530	COG0575	Belongs to the CDS family
SHL15_RS26535	COG2124	cytochrome p450
SHL15_RS26545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SHL15_RS26555	COG4208	sulfate ABC transporter
SHL15_RS26560	COG3842	ATPase activity
SHL15_RS26590	COG4181	ATPase activity
SHL15_RS26595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SHL15_RS26605	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS26615	COG0395	ABC-type sugar transport system, permease component
SHL15_RS26620	COG1175	transmembrane transport
SHL15_RS26630	COG0456	acetyltransferase
SHL15_RS26630	COG0454	-acetyltransferase
SHL15_RS26635	COG3876	Protein conserved in bacteria
SHL15_RS26645	COG1414	Transcriptional regulator
SHL15_RS26665	COG0584	glycerophosphoryl diester phosphodiesterase
SHL15_RS26670	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SHL15_RS26695	COG3842	ATPase activity
SHL15_RS26700	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHL15_RS26705	COG1177	transmembrane transport
SHL15_RS26710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHL15_RS26745	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS26775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SHL15_RS26780	COG0750	zinc metalloprotease
SHL15_RS26785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHL15_RS26795	COG1247	-acetyltransferase
SHL15_RS26800	COG0442	prolyl-tRNA aminoacylation
SHL15_RS26820	COG0779	Required for maturation of 30S ribosomal subunits
SHL15_RS26830	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SHL15_RS26840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SHL15_RS26845	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SHL15_RS26860	COG0455	bacterial-type flagellum organization
SHL15_RS26875	COG3266	domain, Protein
SHL15_RS26880	COG1404	Belongs to the peptidase S8 family
SHL15_RS26920	COG1404	Belongs to the peptidase S8 family
SHL15_RS26950	COG1674	ftsk spoiiie
SHL15_RS26965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SHL15_RS26970	COG1185	polyribonucleotide nucleotidyltransferase activity
SHL15_RS26975	COG0612	Peptidase, M16
SHL15_RS26980	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SHL15_RS27000	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SHL15_RS27005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHL15_RS27010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SHL15_RS27045	COG2770	Histidine kinase
SHL15_RS27045	COG2208	phosphoserine phosphatase activity
SHL15_RS27050	COG2205	protein histidine kinase activity
SHL15_RS27050	COG0784	Response regulator, receiver
SHL15_RS27060	COG1674	ftsk spoiiie
SHL15_RS27070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHL15_RS27080	COG1546	Belongs to the CinA family
SHL15_RS27080	COG1058	Belongs to the CinA family
SHL15_RS27085	COG1396	sequence-specific DNA binding
SHL15_RS27090	COG0783	Belongs to the Dps family
SHL15_RS27105	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHL15_RS27110	COG1201	RNA secondary structure unwinding
SHL15_RS27140	COG0628	permease
SHL15_RS27155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SHL15_RS27185	COG0765	amino acid transport
SHL15_RS27190	COG0765	amino acid transport
SHL15_RS27195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHL15_RS27200	COG1126	abc transporter atp-binding protein
SHL15_RS27205	COG0745	RESPONSE REGULATOR receiver
SHL15_RS27210	COG2205	protein histidine kinase activity
SHL15_RS27215	COG2358	TRAP transporter, solute receptor (TAXI family
SHL15_RS27250	COG0475	glutathione-regulated potassium exporter activity
SHL15_RS27255	COG3469	chitinase activity
SHL15_RS27280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHL15_RS27300	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SHL15_RS27310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SHL15_RS27315	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SHL15_RS27325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SHL15_RS27355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SHL15_RS27360	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SHL15_RS27365	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SHL15_RS27380	COG0588	phosphoglycerate mutase activity
SHL15_RS27400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SHL15_RS27440	COG2186	Transcriptional regulator
SHL15_RS27445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SHL15_RS27450	COG5640	endopeptidase activity
SHL15_RS27460	COG0187	DNA topoisomerase II activity
SHL15_RS27470	COG4585	Histidine kinase
SHL15_RS27475	COG2197	response regulator
SHL15_RS27485	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHL15_RS27500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHL15_RS27510	COG4565	transcriptional regulatory protein
SHL15_RS27515	COG3290	protein histidine kinase activity
SHL15_RS27530	COG0372	Belongs to the citrate synthase family
SHL15_RS27540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SHL15_RS27545	COG0612	Peptidase, M16
SHL15_RS27560	COG1802	Transcriptional regulator
SHL15_RS27565	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SHL15_RS27590	COG1435	thymidine kinase activity
SHL15_RS27625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SHL15_RS27630	COG0483	inositol monophosphate 1-phosphatase activity
SHL15_RS27635	COG0745	RESPONSE REGULATOR receiver
SHL15_RS27640	COG2205	protein histidine kinase activity
SHL15_RS27670	COG0756	dUTP diphosphatase activity
SHL15_RS27680	COG1136	(ABC) transporter
SHL15_RS27710	COG0569	domain protein
SHL15_RS27715	COG0531	amino acid
SHL15_RS27720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SHL15_RS27990	COG0151	Belongs to the GarS family
SHL15_RS28155	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SHL15_RS28180	COG1216	Glycosyl transferase, family 2
SHL15_RS28185	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SHL15_RS28195	COG1201	RNA secondary structure unwinding
SHL15_RS28255	COG4974	Belongs to the 'phage' integrase family
SHL15_RS28265	COG0210	DNA helicase
SHL15_RS28275	COG1401	restriction endodeoxyribonuclease activity
SHL15_RS28280	COG3550	peptidyl-serine autophosphorylation
SHL15_RS28355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SHL15_RS28370	COG1215	transferase activity, transferring glycosyl groups
SHL15_RS28380	COG4310	Domain of unknown function (DUF2172)
SHL15_RS28395	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SHL15_RS28405	COG0438	transferase activity, transferring glycosyl groups
SHL15_RS28430	COG0367	asparagine synthase
SHL15_RS28450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SHL15_RS28490	COG1799	cell septum assembly
SHL15_RS28495	COG0443	Heat shock 70 kDa protein
SHL15_RS28550	COG2890	protein-(glutamine-N5) methyltransferase activity
SHL15_RS28555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SHL15_RS28595	COG2235	arginine
SHL15_RS28600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHL15_RS28605	COG0531	amino acid
SHL15_RS28615	COG1024	Enoyl-CoA hydratase
SHL15_RS28650	COG2188	Transcriptional regulator
SHL15_RS28655	COG2182	Extracellular solute-binding protein
SHL15_RS28660	COG1175	transmembrane transport
SHL15_RS28665	COG0395	ABC-type sugar transport system, permease component
SHL15_RS28670	COG1472	Belongs to the glycosyl hydrolase 3 family
SHL15_RS28700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHL15_RS28715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHL15_RS28730	COG1595	DNA-templated transcription, initiation
SHL15_RS28740	COG1309	transcriptional regulator
SHL15_RS28750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SHL15_RS28755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SHL15_RS28760	COG3290	protein histidine kinase activity
SHL15_RS28765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SHL15_RS28770	COG0443	Heat shock 70 kDa protein
SHL15_RS28775	COG0484	heat shock protein binding
SHL15_RS28785	COG3537	Alpha-1,2-mannosidase
SHL15_RS28795	COG1653	transport
SHL15_RS28800	COG1175	transmembrane transport
SHL15_RS28805	COG0395	ABC-type sugar transport system, permease component
SHL15_RS28810	COG1940	carbohydrate kinase activity
SHL15_RS28815	COG4213	ABC transporter substrate-binding protein
SHL15_RS28825	COG4214	carbohydrate transport
SHL15_RS28830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHL15_RS28835	COG0531	amino acid
SHL15_RS28860	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHL15_RS28860	COG1024	Enoyl-CoA hydratase
SHL15_RS28865	COG0183	Belongs to the thiolase family
SHL15_RS28870	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
SHL15_RS28885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SHL15_RS28900	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHL15_RS28910	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SHL15_RS28915	COG3253	May function as heme-dependent peroxidase
SHL15_RS28935	COG3220	belongs to the UPF0276 family
SHL15_RS28950	COG4152	abc transporter atp-binding protein
SHL15_RS28970	COG0723	plastoquinol--plastocyanin reductase activity
SHL15_RS28970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHL15_RS28975	COG2326	polyphosphate kinase activity
SHL15_RS28980	COG0330	HflC and HflK could
SHL15_RS29015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SHL15_RS29020	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SHL15_RS29035	COG1174	glycine betaine transport
SHL15_RS29055	COG2018	Roadblock/LC7 domain
SHL15_RS29060	COG5002	protein histidine kinase activity
SHL15_RS29065	COG1732	Glycine betaine
SHL15_RS29070	COG2986	histidine ammonia-lyase
SHL15_RS29080	COG0640	Transcriptional regulator
SHL15_RS29180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHL15_RS29185	COG0583	DNA-binding transcription factor activity
SHL15_RS29225	COG1175	transmembrane transport
SHL15_RS29250	COG2409	Drug exporters of the RND superfamily
SHL15_RS29255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SHL15_RS29260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SHL15_RS29285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SHL15_RS29290	COG1116	anion transmembrane transporter activity
SHL15_RS29290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
SHL15_RS29315	COG0529	Catalyzes the synthesis of activated sulfate
SHL15_RS29320	COG0175	sulfate reduction
SHL15_RS29335	COG0456	acetyltransferase
SHL15_RS29350	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS29375	COG3739	integral membrane protein
SHL15_RS29405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
SHL15_RS29425	COG2040	homocysteine
SHL15_RS29430	COG3940	Belongs to the glycosyl hydrolase 43 family
SHL15_RS29495	COG1162	GTPase activity
SHL15_RS29505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SHL15_RS29525	COG0028	Belongs to the TPP enzyme family
SHL15_RS29545	COG1802	Transcriptional regulator
SHL15_RS29555	COG3835	regulator
SHL15_RS29570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHL15_RS29575	COG2252	PERMEase
SHL15_RS29595	COG5634	Uncharacterized conserved protein (DUF2278)
SHL15_RS29610	COG0515	serine threonine protein kinase
SHL15_RS29625	COG1653	transport
SHL15_RS29645	COG2197	response regulator
SHL15_RS29650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SHL15_RS29655	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS29665	COG3960	tartronate-semialdehyde synthase activity
SHL15_RS29685	COG0753	catalase activity
SHL15_RS29690	COG2084	Dehydrogenase
SHL15_RS29695	COG3622	Belongs to the hyi family
SHL15_RS29715	COG2351	hydroxyisourate hydrolase activity
SHL15_RS29725	COG2233	PERMEase
SHL15_RS29735	COG2233	PERMEase
SHL15_RS29745	COG1733	regulation of RNA biosynthetic process
SHL15_RS29760	COG0406	alpha-ribazole phosphatase activity
SHL15_RS29775	COG0436	Aminotransferase
SHL15_RS29780	COG1733	regulation of RNA biosynthetic process
SHL15_RS29800	COG4264	IucA IucC family
SHL15_RS29815	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SHL15_RS29835	COG1414	Transcriptional regulator
SHL15_RS29840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHL15_RS29845	COG4266	Belongs to the allantoicase family
SHL15_RS29880	COG0673	inositol 2-dehydrogenase activity
SHL15_RS29885	COG2188	Transcriptional regulator
SHL15_RS29905	COG1940	carbohydrate kinase activity
SHL15_RS29995	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
SHL15_RS30005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SHL15_RS30015	COG0640	Transcriptional regulator
SHL15_RS30025	COG2814	Major facilitator Superfamily
SHL15_RS30035	COG0514	ATP-dependent DNA helicase (RecQ)
SHL15_RS30045	COG0604	alcohol dehydrogenase
SHL15_RS30050	COG0596	Alpha beta hydrolase
SHL15_RS30105	COG1271	oxidase subunit
SHL15_RS30125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SHL15_RS30130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SHL15_RS30135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SHL15_RS30140	COG0254	rRNA binding
SHL15_RS30150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SHL15_RS30155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SHL15_RS30160	COG0456	acetyltransferase
SHL15_RS30165	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS30180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SHL15_RS30195	COG1597	lipid kinase activity
SHL15_RS30205	COG2801	Transposase and inactivated derivatives
SHL15_RS30245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHL15_RS30250	COG0330	HflC and HflK could
SHL15_RS30325	COG0300	oxidoreductase activity
SHL15_RS30340	COG2197	response regulator
SHL15_RS30345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SHL15_RS30350	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHL15_RS30350	COG1024	Enoyl-CoA hydratase
SHL15_RS30360	COG0477	Major facilitator Superfamily
SHL15_RS30370	COG0300	oxidoreductase activity
SHL15_RS30385	COG2267	carboxylic ester hydrolase activity
SHL15_RS30395	COG0300	oxidoreductase activity
SHL15_RS30405	COG0321	lipoyl(octanoyl) transferase activity
SHL15_RS30480	COG3328	transposase activity
SHL15_RS30490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHL15_RS30535	COG0105	UTP biosynthetic process
SHL15_RS30545	COG0494	nUDIX hydrolase
SHL15_RS30570	COG1201	RNA secondary structure unwinding
SHL15_RS30625	COG0159	tryptophan synthase activity
SHL15_RS30885	COG3387	PFAM Glycoside hydrolase 15-related
SHL15_RS30910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS30945	COG0405	Gamma-glutamyltransferase
SHL15_RS30950	COG0542	response to heat
SHL15_RS30970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SHL15_RS30985	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHL15_RS30990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS30995	COG1953	Uracil, thiamine, allantoin
SHL15_RS31020	COG0095	Lipoate-protein ligase
SHL15_RS31035	COG0483	inositol monophosphate 1-phosphatase activity
SHL15_RS31055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SHL15_RS31070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SHL15_RS31100	COG1929	Belongs to the glycerate kinase type-1 family
SHL15_RS31110	COG0688	phosphatidylethanolamine metabolic process
SHL15_RS31115	COG1960	acyl-CoA dehydrogenase activity
SHL15_RS31125	COG2301	Belongs to the HpcH HpaI aldolase family
SHL15_RS31130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS31130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SHL15_RS31145	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHL15_RS31155	COG0456	acetyltransferase
SHL15_RS31185	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS31185	COG2172	sigma factor antagonist activity
SHL15_RS31185	COG2208	phosphoserine phosphatase activity
SHL15_RS31190	COG4106	trans-aconitate 2-methyltransferase activity
SHL15_RS31195	COG2362	D-Aminopeptidase
SHL15_RS31200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SHL15_RS31210	COG1619	proteins homologs of microcin C7 resistance protein MccF
SHL15_RS31230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS31245	COG1793	dna ligase
SHL15_RS31245	COG3285	dna ligase
SHL15_RS31315	COG0406	alpha-ribazole phosphatase activity
SHL15_RS31320	COG0488	(ABC) transporter
SHL15_RS31335	COG0693	protein deglycase activity
SHL15_RS31350	COG0028	Belongs to the TPP enzyme family
SHL15_RS31375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHL15_RS31410	COG2154	pterin-4-alpha-carbinolamine dehydratase
SHL15_RS31415	COG2226	methyltransferase
SHL15_RS31445	COG4733	cellulase activity
SHL15_RS31445	COG5297	Belongs to the glycosyl hydrolase family 6
SHL15_RS31455	COG5297	Belongs to the glycosyl hydrolase family 6
SHL15_RS31465	COG4106	trans-aconitate 2-methyltransferase activity
SHL15_RS31470	COG4221	oxidoreductase activity
SHL15_RS31485	COG0656	L-ascorbic acid biosynthetic process
SHL15_RS31515	COG1846	Transcriptional regulator
SHL15_RS31520	COG1335	isochorismatase
SHL15_RS31525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SHL15_RS31535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SHL15_RS31540	COG3383	formate dehydrogenase (NAD+) activity
SHL15_RS31545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SHL15_RS31555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHL15_RS31585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHL15_RS31595	COG0045	succinate-CoA ligase (ADP-forming) activity
SHL15_RS31605	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS31620	COG2182	Extracellular solute-binding protein
SHL15_RS31625	COG1175	transmembrane transport
SHL15_RS31630	COG0395	ABC-type sugar transport system, permease component
SHL15_RS31635	COG2723	6-phospho-beta-galactosidase activity
SHL15_RS31680	COG0297	glycogen (starch) synthase activity
SHL15_RS31700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHL15_RS31725	COG0477	Major facilitator Superfamily
SHL15_RS31735	COG3467	pyridoxamine 5'-phosphate
SHL15_RS31740	COG2084	Dehydrogenase
SHL15_RS31750	COG0477	Major facilitator Superfamily
SHL15_RS31760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SHL15_RS31765	COG1082	Xylose isomerase domain protein TIM barrel
SHL15_RS31765	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SHL15_RS31775	COG0588	phosphoglycerate mutase activity
SHL15_RS31780	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SHL15_RS31785	COG0166	Belongs to the GPI family
SHL15_RS31800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SHL15_RS31825	COG1486	melibiose metabolic process
SHL15_RS31830	COG3469	chitinase activity
SHL15_RS31840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SHL15_RS31880	COG1175	transmembrane transport
SHL15_RS31885	COG0395	ABC-type sugar transport system, permease component
SHL15_RS31890	COG0366	Alpha amylase catalytic
SHL15_RS31900	COG3511	phospholipase C
SHL15_RS31930	COG1672	PFAM Archaeal ATPase
SHL15_RS31930	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SHL15_RS31940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS31950	COG3485	protocatechuate 3,4-dioxygenase
SHL15_RS31955	COG3485	protocatechuate 3,4-dioxygenase
SHL15_RS31975	COG1793	dna ligase
SHL15_RS32005	COG1834	amidinotransferase
SHL15_RS32010	COG0488	(ABC) transporter
SHL15_RS32035	COG1515	deoxyribonuclease V activity
SHL15_RS32040	COG3268	Saccharopine dehydrogenase
SHL15_RS32045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SHL15_RS32050	COG0183	Belongs to the thiolase family
SHL15_RS32055	COG1250	3-hydroxyacyl-CoA dehydrogenase
SHL15_RS32055	COG1024	Enoyl-CoA hydratase
SHL15_RS32065	COG1113	amino acid transport
SHL15_RS32070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHL15_RS32080	COG2936	dipeptidyl-peptidase activity
SHL15_RS32090	COG0488	(ABC) transporter
SHL15_RS32095	COG2183	response to ionizing radiation
SHL15_RS32100	COG1024	Enoyl-CoA hydratase
SHL15_RS32110	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SHL15_RS32155	COG1134	teichoic acid transport
SHL15_RS32160	COG1562	ergosterol biosynthetic process
SHL15_RS32170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SHL15_RS32180	COG1657	PFAM Prenyltransferase squalene oxidase
SHL15_RS32195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SHL15_RS32200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHL15_RS32230	COG2755	lipolytic protein G-D-S-L family
SHL15_RS32240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHL15_RS32275	COG1063	alcohol dehydrogenase
SHL15_RS32280	COG0156	8-amino-7-oxononanoate synthase activity
SHL15_RS32285	COG0583	DNA-binding transcription factor activity
SHL15_RS32310	COG3958	Transketolase
SHL15_RS32315	COG3959	Transketolase, thiamine diphosphate binding domain
SHL15_RS32345	COG0561	phosphatase activity
SHL15_RS32370	COG2267	carboxylic ester hydrolase activity
SHL15_RS32375	COG0183	Belongs to the thiolase family
SHL15_RS32380	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS32390	COG0546	phosphoglycolate phosphatase activity
SHL15_RS32425	COG0726	polysaccharide deacetylase
SHL15_RS32440	COG1653	transport
SHL15_RS32445	COG1175	transmembrane transport
SHL15_RS32455	COG1472	Belongs to the glycosyl hydrolase 3 family
SHL15_RS32475	COG0395	ABC-type sugar transport system, permease component
SHL15_RS32480	COG1175	transmembrane transport
SHL15_RS32485	COG1653	transport
SHL15_RS32490	COG2188	Transcriptional regulator
SHL15_RS32520	COG0673	inositol 2-dehydrogenase activity
SHL15_RS32525	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS32535	COG1609	Transcriptional regulator
SHL15_RS32540	COG0673	inositol 2-dehydrogenase activity
SHL15_RS32545	COG1609	Transcriptional regulator
SHL15_RS32565	COG0477	Major facilitator Superfamily
SHL15_RS32585	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SHL15_RS32590	COG3275	phosphorelay sensor kinase activity
SHL15_RS32595	COG0531	amino acid
SHL15_RS32605	COG3938	Belongs to the proline racemase family
SHL15_RS32610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SHL15_RS32615	COG0446	pyridine nucleotide-disulphide oxidoreductase
SHL15_RS32625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHL15_RS32640	COG1126	abc transporter atp-binding protein
SHL15_RS32645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SHL15_RS32650	COG0456	acetyltransferase
SHL15_RS32655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS32660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS32665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS32675	COG2197	response regulator
SHL15_RS32710	COG2838	Isocitrate dehydrogenase
SHL15_RS32720	COG0668	transmembrane transport
SHL15_RS32725	COG0531	amino acid
SHL15_RS32735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHL15_RS32740	COG2022	thiamine diphosphate biosynthetic process
SHL15_RS32740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHL15_RS32750	COG1024	Enoyl-CoA hydratase
SHL15_RS32760	COG1132	(ABC) transporter
SHL15_RS32775	COG2080	2 iron, 2 sulfur cluster binding
SHL15_RS32780	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SHL15_RS32785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHL15_RS32815	COG1335	isochorismatase
SHL15_RS32820	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS32845	COG0655	NAD(P)H dehydrogenase (quinone) activity
SHL15_RS32865	COG1309	transcriptional regulator
SHL15_RS32900	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SHL15_RS32925	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
SHL15_RS32950	COG0582	viral genome integration into host DNA
SHL15_RS33250	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHL15_RS33255	COG0738	Major facilitator superfamily
SHL15_RS33305	COG0640	Transcriptional regulator
SHL15_RS33315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SHL15_RS33320	COG1247	-acetyltransferase
SHL15_RS33330	COG1793	dna ligase
SHL15_RS33460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SHL15_RS33480	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHL15_RS33485	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SHL15_RS33495	COG2192	nodulation
SHL15_RS33500	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SHL15_RS33510	COG0546	phosphoglycolate phosphatase activity
SHL15_RS33545	COG1434	Gram-negative-bacterium-type cell wall biogenesis
SHL15_RS33565	COG0210	DNA helicase
SHL15_RS33570	COG1111	helicase
SHL15_RS33570	COG1205	dead DEAH box helicase
SHL15_RS33580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SHL15_RS33595	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SHL15_RS33605	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
SHL15_RS33625	COG0297	glycogen (starch) synthase activity
SHL15_RS33630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SHL15_RS33635	COG3537	Alpha-1,2-mannosidase
SHL15_RS33655	COG0154	amidase activity
SHL15_RS33665	COG2186	Transcriptional regulator
SHL15_RS33675	COG1129	ABC transporter
SHL15_RS33685	COG4948	Mandelate Racemase Muconate Lactonizing
SHL15_RS33720	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SHL15_RS33745	COG0531	amino acid
SHL15_RS33755	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SHL15_RS33755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SHL15_RS33760	COG0726	polysaccharide deacetylase
SHL15_RS33795	COG0583	DNA-binding transcription factor activity
SHL15_RS33805	COG0583	DNA-binding transcription factor activity
SHL15_RS33815	COG1053	succinate dehydrogenase
SHL15_RS33820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SHL15_RS33845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SHL15_RS33855	COG3360	Dodecin
SHL15_RS33860	COG2182	Extracellular solute-binding protein
SHL15_RS33865	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SHL15_RS33870	COG0121	glutamine amidotransferase
SHL15_RS33875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SHL15_RS33925	COG2268	Band 7 protein
SHL15_RS33970	COG1609	Transcriptional regulator
SHL15_RS33975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SHL15_RS33985	COG0242	peptide deformylase activity
SHL15_RS34010	COG3336	cytochrome c oxidase
SHL15_RS34025	COG0753	catalase activity
SHL15_RS34060	COG0745	RESPONSE REGULATOR receiver
SHL15_RS34065	COG5002	protein histidine kinase activity
SHL15_RS34075	COG1595	DNA-templated transcription, initiation
SHL15_RS34085	COG0395	ABC-type sugar transport system, permease component
SHL15_RS34090	COG1175	transmembrane transport
SHL15_RS34095	COG2182	Extracellular solute-binding protein
SHL15_RS34100	COG1501	Belongs to the glycosyl hydrolase 31 family
SHL15_RS34120	COG0753	catalase activity
SHL15_RS34140	COG0584	glycerophosphoryl diester phosphodiesterase
SHL15_RS34145	COG1785	Belongs to the alkaline phosphatase family
SHL15_RS34200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SHL15_RS34215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SHL15_RS34225	COG0542	response to heat
SHL15_RS34235	COG1174	glycine betaine transport
SHL15_RS34255	COG1556	Lactate utilization protein
SHL15_RS34260	COG1139	Iron-sulfur cluster binding protein
SHL15_RS34265	COG0247	lactate metabolic process
SHL15_RS34270	COG1070	Carbohydrate kinase
SHL15_RS34275	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS34275	COG3347	Dehydrogenase
SHL15_RS34285	COG1129	ABC transporter
SHL15_RS34290	COG1172	Belongs to the binding-protein-dependent transport system permease family
SHL15_RS34320	COG1609	Transcriptional regulator
SHL15_RS34330	COG1357	PFAM Pentapeptide repeats (8 copies)
SHL15_RS34340	COG1309	transcriptional regulator
SHL15_RS34355	COG2706	6-phosphogluconolactonase activity
SHL15_RS34395	COG1940	carbohydrate kinase activity
SHL15_RS34395	COG1846	Transcriptional regulator
SHL15_RS34410	COG0546	phosphoglycolate phosphatase activity
SHL15_RS34415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHL15_RS34415	COG1796	DNA polymerase
SHL15_RS34420	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS34465	COG1006	Multisubunit Na H antiporter MnhC subunit
SHL15_RS34470	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHL15_RS34515	COG0435	Glutathione S-transferase
SHL15_RS34535	COG2124	cytochrome p450
SHL15_RS34550	COG0667	Aldo Keto reductase
SHL15_RS34585	COG1595	DNA-templated transcription, initiation
SHL15_RS34595	COG3250	beta-galactosidase activity
SHL15_RS34640	COG2890	protein-(glutamine-N5) methyltransferase activity
SHL15_RS34655	COG0300	oxidoreductase activity
SHL15_RS34665	COG0726	polysaccharide deacetylase
SHL15_RS34680	COG2274	protein secretion by the type I secretion system
SHL15_RS34715	COG2124	cytochrome p450
SHL15_RS34735	COG3251	PFAM MbtH domain protein
SHL15_RS34775	COG0477	Major facilitator Superfamily
SHL15_RS34785	COG0247	lactate metabolic process
SHL15_RS34785	COG0277	FAD linked oxidase domain protein
SHL15_RS34790	COG0300	oxidoreductase activity
SHL15_RS34820	COG0596	Alpha beta hydrolase
SHL15_RS34825	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS34835	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SHL15_RS34875	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SHL15_RS34900	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS34905	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS34925	COG1846	Transcriptional regulator
SHL15_RS34925	COG1940	carbohydrate kinase activity
SHL15_RS34965	COG1309	transcriptional regulator
SHL15_RS34985	COG0367	asparagine synthase
SHL15_RS35060	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHL15_RS35075	COG3387	PFAM Glycoside hydrolase 15-related
SHL15_RS35095	COG3290	protein histidine kinase activity
SHL15_RS35110	COG2045	Belongs to the ComB family
SHL15_RS35140	COG0456	acetyltransferase
SHL15_RS35150	COG2264	protein methyltransferase activity
SHL15_RS35230	COG0667	Aldo Keto reductase
SHL15_RS35240	COG2124	cytochrome p450
SHL15_RS35270	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
SHL15_RS35295	COG0248	Ppx GppA phosphatase
SHL15_RS35325	COG1982	Orn Lys Arg decarboxylase major
SHL15_RS35345	COG2172	sigma factor antagonist activity
SHL15_RS35350	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS35355	COG1366	Belongs to the anti-sigma-factor antagonist family
SHL15_RS35395	COG2197	response regulator
SHL15_RS35405	COG0583	DNA-binding transcription factor activity
SHL15_RS35430	COG0531	amino acid
SHL15_RS35445	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS35465	COG0596	Alpha beta hydrolase
SHL15_RS35475	COG0395	ABC-type sugar transport system, permease component
SHL15_RS35500	COG2755	lipolytic protein G-D-S-L family
SHL15_RS35510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHL15_RS35525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SHL15_RS35550	COG1177	transmembrane transport
SHL15_RS35555	COG1176	ABC-type spermidine putrescine transport system, permease component I
SHL15_RS35560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SHL15_RS35565	COG3842	ATPase activity
SHL15_RS35580	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SHL15_RS35585	COG1733	regulation of RNA biosynthetic process
SHL15_RS35620	COG3340	Belongs to the peptidase S51 family
SHL15_RS35635	COG0277	FAD linked oxidase domain protein
SHL15_RS35640	COG1597	lipid kinase activity
SHL15_RS35650	COG0542	response to heat
SHL15_RS35665	COG0640	Transcriptional regulator
SHL15_RS35670	COG1316	TRANSCRIPTIONal
SHL15_RS35690	COG2814	Major facilitator Superfamily
SHL15_RS35710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHL15_RS35715	COG2409	Drug exporters of the RND superfamily
SHL15_RS35725	COG1309	transcriptional regulator
SHL15_RS35745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SHL15_RS35770	COG1175	transmembrane transport
SHL15_RS35775	COG2182	Extracellular solute-binding protein
SHL15_RS35805	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SHL15_RS35810	COG1132	(ABC) transporter
SHL15_RS35820	COG1271	oxidase subunit
SHL15_RS35825	COG0783	Belongs to the Dps family
SHL15_RS35865	COG3608	succinylglutamate desuccinylase aspartoacylase
SHL15_RS35865	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SHL15_RS35870	COG0028	Belongs to the TPP enzyme family
SHL15_RS35885	COG3619	membrane
SHL15_RS35890	COG2259	Doxx family
SHL15_RS35895	COG1335	isochorismatase
SHL15_RS35900	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
SHL15_RS35935	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
SHL15_RS35935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SHL15_RS35965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHL15_RS35975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
SHL15_RS35980	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SHL15_RS35985	COG1082	Xylose isomerase domain protein TIM barrel
SHL15_RS36000	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SHL15_RS36025	COG0326	Molecular chaperone. Has ATPase activity
SHL15_RS36055	COG0583	DNA-binding transcription factor activity
SHL15_RS36140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SHL15_RS36145	COG1120	ATPase activity
SHL15_RS36155	COG5640	endopeptidase activity
SHL15_RS36160	COG0583	DNA-binding transcription factor activity
SHL15_RS36180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHL15_RS36185	COG0110	maltose O-acetyltransferase activity
SHL15_RS36190	COG0318	PFAM AMP-dependent synthetase and ligase
SHL15_RS36195	COG0492	ferredoxin-NADP+ reductase activity
SHL15_RS36210	COG0475	glutathione-regulated potassium exporter activity
SHL15_RS36230	COG0395	ABC-type sugar transport system, permease component
SHL15_RS36245	COG1609	Transcriptional regulator
SHL15_RS36250	COG0583	DNA-binding transcription factor activity
SHL15_RS36290	COG2319	Wd-40 repeat
SHL15_RS36290	COG4249	Peptidase C14 caspase catalytic subunit p20
SHL15_RS36330	COG2154	pterin-4-alpha-carbinolamine dehydratase
SHL15_RS36350	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS36370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHL15_RS36375	COG1660	Displays ATPase and GTPase activities
SHL15_RS36385	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SHL15_RS36395	COG2226	methyltransferase
SHL15_RS36400	COG3623	hexulose-6-phosphate isomerase
SHL15_RS36410	COG0076	glutamate decarboxylase activity
SHL15_RS36420	COG1063	alcohol dehydrogenase
SHL15_RS36425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
SHL15_RS36445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SHL15_RS36455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SHL15_RS36475	COG0431	NADPH-dependent FMN reductase
SHL15_RS36510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHL15_RS36540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHL15_RS36605	COG3851	Histidine kinase
SHL15_RS36610	COG2197	response regulator
SHL15_RS36615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHL15_RS36660	COG1733	regulation of RNA biosynthetic process
SHL15_RS36685	COG0583	DNA-binding transcription factor activity
SHL15_RS36700	COG1397	ADP-ribosylglycohydrolase
SHL15_RS36745	COG0596	Alpha beta hydrolase
SHL15_RS36750	COG1595	DNA-templated transcription, initiation
SHL15_RS36760	COG1278	Cold shock
SHL15_RS36810	COG2508	Transcriptional regulator
SHL15_RS36825	COG0179	Fumarylacetoacetate (FAA) hydrolase
SHL15_RS36840	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SHL15_RS36860	COG2124	cytochrome p450
SHL15_RS36885	COG0671	phosphoesterase, PA-phosphatase related
SHL15_RS36890	COG0671	phosphoesterase, PA-phosphatase related
SHL15_RS36910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SHL15_RS36940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SHL15_RS36975	COG4585	Histidine kinase
SHL15_RS36980	COG2197	response regulator
SHL15_RS36990	COG2272	Belongs to the type-B carboxylesterase lipase family
SHL15_RS37005	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS37055	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS37110	COG0475	glutathione-regulated potassium exporter activity
SHL15_RS37125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SHL15_RS37145	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SHL15_RS37185	COG0477	Major facilitator Superfamily
SHL15_RS37190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHL15_RS37225	COG1476	TRANSCRIPTIONal
SHL15_RS37230	COG3903	Transcriptional regulator
SHL15_RS37230	COG3629	intracellular signal transduction
SHL15_RS37260	COG0702	epimerase
SHL15_RS37285	COG0492	ferredoxin-NADP+ reductase activity
SHL15_RS37330	COG2814	Major facilitator Superfamily
SHL15_RS37335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHL15_RS37350	COG5285	phytanoyl-CoA dioxygenase
SHL15_RS37375	COG2235	arginine
SHL15_RS37380	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SHL15_RS37405	COG1309	transcriptional regulator
SHL15_RS37435	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SHL15_RS37475	COG1012	belongs to the aldehyde dehydrogenase family
SHL15_RS37485	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SHL15_RS37510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHL15_RS37555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHL15_RS37565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SHL15_RS37580	COG0745	RESPONSE REGULATOR receiver
SHL15_RS37585	COG2205	protein histidine kinase activity
SHL15_RS37590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SHL15_RS37595	COG1181	Belongs to the D-alanine--D-alanine ligase family
SHL15_RS37600	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SHL15_RS37645	COG2801	Transposase and inactivated derivatives
SHL15_RS37720	COG3794	PFAM blue (type 1) copper domain protein
SHL15_RS38765	COG0069	glutamate synthase activity
SHL15_RS38770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHL15_RS39220	COG2814	Major facilitator Superfamily
SHL15_RS39900	COG3321	synthase
SHL15_RS39900	COG0604	alcohol dehydrogenase
SHL15_RS40025	COG1028	Short-chain dehydrogenase reductase Sdr
SHL15_RS40245	COG1295	ribonuclease BN
SHL15_RS40540	COG0243	molybdopterin cofactor binding
SHL15_RS40540	COG3383	formate dehydrogenase (NAD+) activity
SHL15_RS40965	COG0366	Alpha amylase catalytic
SHL15_RS40970	COG0366	Alpha amylase catalytic
SHL15_RS41080	COG3573	Dehydrogenase
SHL15_RS42600	COG0494	nUDIX hydrolase
SHL15_RS42815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SHL15_RS42890	COG1132	(ABC) transporter
SHL15_RS43085	COG1113	amino acid transport
SHL15_RS43320	COG0830	nickel cation binding
SHL15_RS43815	COG2124	cytochrome p450
SHL15_RS43935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SHL15_RS44165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHL15_RS44640	COG0505	Belongs to the CarA family
SHL15_RS44765	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SHL15_RS44985	COG1464	Belongs to the NlpA lipoprotein family
SHL15_RS45110	COG1438	arginine binding
SHL15_RS45190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHL15_RS45190	COG0072	phenylalanine-tRNA ligase activity
SHL15_RS45310	COG0564	pseudouridine synthase activity