locus-tag	class	description
D0C37_RS00105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0C37_RS00140	COG0492	ferredoxin-NADP+ reductase activity
D0C37_RS00145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0C37_RS00155	COG0798	PFAM Bile acid sodium symporter
D0C37_RS00160	COG2072	flavoprotein involved in K transport
D0C37_RS00165	COG0659	secondary active sulfate transmembrane transporter activity
D0C37_RS00170	COG0789	Transcriptional regulator
D0C37_RS00185	COG0640	Transcriptional regulator
D0C37_RS00190	COG2072	flavoprotein involved in K transport
D0C37_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS00270	COG1959	2 iron, 2 sulfur cluster binding
D0C37_RS00305	COG2318	DinB family
D0C37_RS00325	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS00350	COG0477	Major facilitator Superfamily
D0C37_RS00375	COG4335	DNA alkylation repair
D0C37_RS00385	COG3321	synthase
D0C37_RS00385	COG0300	oxidoreductase activity
D0C37_RS00385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0C37_RS00385	COG4221	oxidoreductase activity
D0C37_RS00430	COG1404	Belongs to the peptidase S8 family
D0C37_RS00460	COG0515	serine threonine protein kinase
D0C37_RS00495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0C37_RS00500	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0C37_RS00505	COG2080	2 iron, 2 sulfur cluster binding
D0C37_RS00515	COG2197	response regulator
D0C37_RS00520	COG4585	Histidine kinase
D0C37_RS00525	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D0C37_RS00545	COG0477	Major facilitator Superfamily
D0C37_RS00630	COG0596	Alpha beta hydrolase
D0C37_RS00650	COG0477	Major facilitator Superfamily
D0C37_RS00670	COG1793	dna ligase
D0C37_RS00705	COG0277	FAD linked oxidase domain protein
D0C37_RS00750	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS00755	COG0589	response to stress
D0C37_RS00760	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0C37_RS00765	COG2813	Specifically methylates the guanine in position
D0C37_RS00775	COG2356	endonuclease I
D0C37_RS00805	COG2084	Dehydrogenase
D0C37_RS00840	COG1007	ATP synthesis coupled electron transport
D0C37_RS00845	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS00850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0C37_RS00855	COG0713	ATP synthesis coupled electron transport
D0C37_RS00865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0C37_RS00875	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS00885	COG4733	cellulase activity
D0C37_RS00885	COG5297	Belongs to the glycosyl hydrolase family 6
D0C37_RS00900	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0C37_RS00900	COG1902	pentaerythritol trinitrate reductase activity
D0C37_RS00910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0C37_RS00930	COG3547	Transposase (IS116 IS110 IS902 family)
D0C37_RS00950	COG0475	glutathione-regulated potassium exporter activity
D0C37_RS00970	COG2197	response regulator
D0C37_RS00980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0C37_RS00995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0C37_RS01005	COG0385	Bile acid
D0C37_RS01010	COG3268	Saccharopine dehydrogenase
D0C37_RS01025	COG0640	Transcriptional regulator
D0C37_RS01030	COG2217	Heavy metal translocating P-type atpase
D0C37_RS01040	COG0531	amino acid
D0C37_RS01065	COG1278	Cold shock
D0C37_RS01070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS01090	COG0477	Major facilitator Superfamily
D0C37_RS01105	COG0328	RNA-DNA hybrid ribonuclease activity
D0C37_RS01110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS01115	COG0431	NADPH-dependent FMN reductase
D0C37_RS01145	COG1595	DNA-templated transcription, initiation
D0C37_RS01165	COG0149	triose-phosphate isomerase activity
D0C37_RS01215	COG0726	polysaccharide deacetylase
D0C37_RS01220	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS01225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0C37_RS01230	COG1131	(ABC) transporter
D0C37_RS01250	COG0326	Molecular chaperone. Has ATPase activity
D0C37_RS01280	COG0346	lactoylglutathione lyase activity
D0C37_RS01285	COG0640	Transcriptional regulator
D0C37_RS01300	COG1120	ATPase activity
D0C37_RS01335	COG1349	DNA-binding transcription factor activity
D0C37_RS01345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0C37_RS01345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0C37_RS01345	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D0C37_RS01350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0C37_RS01355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0C37_RS01395	COG2226	methyltransferase
D0C37_RS01420	COG0149	triose-phosphate isomerase activity
D0C37_RS01425	COG0149	triose-phosphate isomerase activity
D0C37_RS01450	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS01465	COG0513	Belongs to the DEAD box helicase family
D0C37_RS01475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0C37_RS01490	COG0633	Ferredoxin
D0C37_RS01490	COG3217	Mosc domain protein beta barrel domain protein
D0C37_RS01510	COG1349	DNA-binding transcription factor activity
D0C37_RS01530	COG1940	carbohydrate kinase activity
D0C37_RS01540	COG2223	nitrite transmembrane transporter activity
D0C37_RS01565	COG2197	response regulator
D0C37_RS01580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0C37_RS01595	COG1609	Transcriptional regulator
D0C37_RS01600	COG2318	DinB family
D0C37_RS01610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D0C37_RS01655	COG0584	glycerophosphoryl diester phosphodiesterase
D0C37_RS01670	COG1846	Transcriptional regulator
D0C37_RS01675	COG1289	transmembrane transporter activity
D0C37_RS01690	COG0671	phosphoesterase, PA-phosphatase related
D0C37_RS01720	COG2233	PERMEase
D0C37_RS01725	COG0640	Transcriptional regulator
D0C37_RS01730	COG1902	pentaerythritol trinitrate reductase activity
D0C37_RS01745	COG2197	response regulator
D0C37_RS01755	COG0586	Pfam SNARE associated Golgi protein
D0C37_RS01760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0C37_RS01775	COG2706	6-phosphogluconolactonase activity
D0C37_RS01790	COG0071	Belongs to the small heat shock protein (HSP20) family
D0C37_RS01865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0C37_RS01890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0C37_RS01895	COG1120	ATPase activity
D0C37_RS01900	COG2207	Transcriptional regulator
D0C37_RS01905	COG2814	Major facilitator Superfamily
D0C37_RS01945	COG1472	Belongs to the glycosyl hydrolase 3 family
D0C37_RS01955	COG1175	transmembrane transport
D0C37_RS01965	COG1609	Transcriptional regulator
D0C37_RS01985	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0C37_RS01985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0C37_RS02005	COG3415	Transposase
D0C37_RS02005	COG2801	Transposase and inactivated derivatives
D0C37_RS02020	COG0443	Heat shock 70 kDa protein
D0C37_RS02115	COG0017	Asparaginyl-tRNA synthetase
D0C37_RS02120	COG1304	FMN binding
D0C37_RS02125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0C37_RS02150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS02200	COG3251	PFAM MbtH domain protein
D0C37_RS02215	COG1024	Enoyl-CoA hydratase
D0C37_RS02220	COG1024	Enoyl-CoA hydratase
D0C37_RS02225	COG0432	Pfam Uncharacterised protein family UPF0047
D0C37_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0C37_RS02235	COG1116	anion transmembrane transporter activity
D0C37_RS02245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS02255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0C37_RS02260	COG1132	(ABC) transporter
D0C37_RS02280	COG1132	(ABC) transporter
D0C37_RS02285	COG1132	(ABC) transporter
D0C37_RS02300	COG1946	Acyl-CoA thioesterase
D0C37_RS02315	COG2018	Roadblock/LC7 domain
D0C37_RS02360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0C37_RS02385	COG1070	Carbohydrate kinase
D0C37_RS02395	COG2124	cytochrome p450
D0C37_RS02400	COG2130	NADP-dependent
D0C37_RS02405	COG1233	COG1233 Phytoene dehydrogenase and related
D0C37_RS02475	COG0477	Major facilitator Superfamily
D0C37_RS02480	COG0183	Belongs to the thiolase family
D0C37_RS02485	COG0583	DNA-binding transcription factor activity
D0C37_RS02490	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D0C37_RS02495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0C37_RS02500	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS02505	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS02510	COG2391	methyltransferase activity
D0C37_RS02575	COG0740	serine-type endopeptidase activity
D0C37_RS02580	COG0740	serine-type endopeptidase activity
D0C37_RS02635	COG3959	Transketolase, thiamine diphosphate binding domain
D0C37_RS02640	COG3958	Transketolase
D0C37_RS02720	COG0367	asparagine synthase
D0C37_RS02730	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS02735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0C37_RS02760	COG2272	Belongs to the type-B carboxylesterase lipase family
D0C37_RS02800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0C37_RS02805	COG1088	dTDP-glucose 4,6-dehydratase activity
D0C37_RS02815	COG1316	TRANSCRIPTIONal
D0C37_RS02825	COG2755	lipolytic protein G-D-S-L family
D0C37_RS02830	COG2365	Tyrosine phosphatase family
D0C37_RS02860	COG1657	PFAM Prenyltransferase squalene oxidase
D0C37_RS02870	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D0C37_RS02880	COG1562	ergosterol biosynthetic process
D0C37_RS02885	COG1388	LysM domain
D0C37_RS02885	COG1134	teichoic acid transport
D0C37_RS02910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0C37_RS02925	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D0C37_RS02935	COG1162	GTPase activity
D0C37_RS02950	COG1024	Enoyl-CoA hydratase
D0C37_RS02960	COG2183	response to ionizing radiation
D0C37_RS02975	COG1802	Transcriptional regulator
D0C37_RS02985	COG0402	S-adenosylhomocysteine deaminase activity
D0C37_RS03015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0C37_RS03020	COG0789	Transcriptional regulator
D0C37_RS03025	COG2826	transposase and inactivated derivatives, IS30 family
D0C37_RS03040	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS03040	COG1024	Enoyl-CoA hydratase
D0C37_RS03045	COG0183	Belongs to the thiolase family
D0C37_RS03050	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS03055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0C37_RS03060	COG1683	Conserved Protein
D0C37_RS03065	COG1515	deoxyribonuclease V activity
D0C37_RS03095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0C37_RS03105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0C37_RS03105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0C37_RS03115	COG0488	(ABC) transporter
D0C37_RS03135	COG2197	response regulator
D0C37_RS03150	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS03180	COG0254	rRNA binding
D0C37_RS03190	COG1793	dna ligase
D0C37_RS03195	COG1024	Enoyl-CoA hydratase
D0C37_RS03230	COG0789	Transcriptional regulator
D0C37_RS03255	COG4249	Peptidase C14 caspase catalytic subunit p20
D0C37_RS03255	COG2319	Wd-40 repeat
D0C37_RS03285	COG2274	protein secretion by the type I secretion system
D0C37_RS03290	COG1846	Transcriptional regulator
D0C37_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS03350	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS03370	COG2814	Major facilitator Superfamily
D0C37_RS03375	COG2259	Doxx family
D0C37_RS03385	COG1869	D-ribose catabolic process
D0C37_RS03390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0C37_RS03395	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS03400	COG1129	ABC transporter
D0C37_RS03405	COG1609	Transcriptional regulator
D0C37_RS03425	COG1295	ribonuclease BN
D0C37_RS03490	COG0673	inositol 2-dehydrogenase activity
D0C37_RS03500	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS03505	COG1129	ABC transporter
D0C37_RS03510	COG1940	carbohydrate kinase activity
D0C37_RS03515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0C37_RS03525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0C37_RS03535	COG0583	DNA-binding transcription factor activity
D0C37_RS03540	COG1115	amino acid carrier protein
D0C37_RS03565	COG2154	pterin-4-alpha-carbinolamine dehydratase
D0C37_RS03595	COG1140	nitrate reductase beta subunit
D0C37_RS03655	COG0693	protein deglycase activity
D0C37_RS03665	COG1597	lipid kinase activity
D0C37_RS03670	COG4106	trans-aconitate 2-methyltransferase activity
D0C37_RS03685	COG3226	Transcriptional regulator
D0C37_RS03690	COG0789	Transcriptional regulator
D0C37_RS03710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0C37_RS03730	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0C37_RS03740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0C37_RS03770	COG0596	Alpha beta hydrolase
D0C37_RS03780	COG1937	Protein conserved in bacteria
D0C37_RS03790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0C37_RS03790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0C37_RS03795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0C37_RS03800	COG0730	response to heat
D0C37_RS03810	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS03820	COG0604	alcohol dehydrogenase
D0C37_RS03825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0C37_RS03825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0C37_RS03830	COG2301	Belongs to the HpcH HpaI aldolase family
D0C37_RS03845	COG0688	phosphatidylethanolamine metabolic process
D0C37_RS03855	COG1929	Belongs to the glycerate kinase type-1 family
D0C37_RS03860	COG0488	(ABC) transporter
D0C37_RS03870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0C37_RS03885	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D0C37_RS03910	COG0159	tryptophan synthase activity
D0C37_RS03920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D0C37_RS03935	COG0483	inositol monophosphate 1-phosphatase activity
D0C37_RS03945	COG0095	Lipoate-protein ligase
D0C37_RS03965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0C37_RS03990	COG0405	Gamma-glutamyltransferase
D0C37_RS04020	COG0765	amino acid transport
D0C37_RS04025	COG0765	amino acid transport
D0C37_RS04030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0C37_RS04035	COG1126	abc transporter atp-binding protein
D0C37_RS04070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0C37_RS04075	COG2814	Major facilitator Superfamily
D0C37_RS04090	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS04100	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS04115	COG2133	pyrroloquinoline quinone binding
D0C37_RS04115	COG5183	chlorophyll binding
D0C37_RS04120	COG1132	(ABC) transporter
D0C37_RS04125	COG1132	(ABC) transporter
D0C37_RS04160	COG2197	response regulator
D0C37_RS04170	COG0464	growth
D0C37_RS04270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0C37_RS04280	COG1940	carbohydrate kinase activity
D0C37_RS04290	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS04300	COG2188	Transcriptional regulator
D0C37_RS04305	COG0673	inositol 2-dehydrogenase activity
D0C37_RS04325	COG2197	response regulator
D0C37_RS04330	COG4585	Histidine kinase
D0C37_RS04345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0C37_RS04350	COG1414	Transcriptional regulator
D0C37_RS04365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0C37_RS04370	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0C37_RS04375	COG2080	2 iron, 2 sulfur cluster binding
D0C37_RS04380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D0C37_RS04395	COG4941	Belongs to the sigma-70 factor family
D0C37_RS04400	COG3795	YCII-related domain
D0C37_RS04405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0C37_RS04455	COG2233	PERMEase
D0C37_RS04470	COG2351	hydroxyisourate hydrolase activity
D0C37_RS04490	COG3622	Belongs to the hyi family
D0C37_RS04495	COG2084	Dehydrogenase
D0C37_RS04500	COG0753	catalase activity
D0C37_RS04510	COG3960	tartronate-semialdehyde synthase activity
D0C37_RS04520	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS04525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0C37_RS04530	COG2197	response regulator
D0C37_RS04540	COG1309	transcriptional regulator
D0C37_RS04580	COG2252	PERMEase
D0C37_RS04585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0C37_RS04600	COG3835	regulator
D0C37_RS04605	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D0C37_RS04615	COG1802	Transcriptional regulator
D0C37_RS04635	COG0028	Belongs to the TPP enzyme family
D0C37_RS04655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0C37_RS04660	COG1162	GTPase activity
D0C37_RS04670	COG2365	Tyrosine phosphatase family
D0C37_RS04710	COG1595	DNA-templated transcription, initiation
D0C37_RS04730	COG0702	epimerase
D0C37_RS04740	COG2409	Drug exporters of the RND superfamily
D0C37_RS04750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS04755	COG1120	ATPase activity
D0C37_RS04765	COG2255	four-way junction helicase activity
D0C37_RS04790	COG2040	homocysteine
D0C37_RS04810	COG3415	Transposase
D0C37_RS04810	COG2801	Transposase and inactivated derivatives
D0C37_RS04830	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS04840	COG0604	alcohol dehydrogenase
D0C37_RS04915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0C37_RS04925	COG0175	sulfate reduction
D0C37_RS04930	COG0529	Catalyzes the synthesis of activated sulfate
D0C37_RS04955	COG1116	anion transmembrane transporter activity
D0C37_RS04960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0C37_RS04975	COG0386	Belongs to the glutathione peroxidase family
D0C37_RS05010	COG5002	protein histidine kinase activity
D0C37_RS05010	COG2176	DNA-directed DNA polymerase activity
D0C37_RS05080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0C37_RS05085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0C37_RS05110	COG1595	DNA-templated transcription, initiation
D0C37_RS05125	COG0726	polysaccharide deacetylase
D0C37_RS05140	COG3220	belongs to the UPF0276 family
D0C37_RS05150	COG3253	May function as heme-dependent peroxidase
D0C37_RS05155	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D0C37_RS05165	COG0446	pyridine nucleotide-disulphide oxidoreductase
D0C37_RS05170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D0C37_RS05190	COG0183	Belongs to the thiolase family
D0C37_RS05195	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS05195	COG1024	Enoyl-CoA hydratase
D0C37_RS05220	COG2843	Capsule synthesis protein
D0C37_RS05250	COG0531	amino acid
D0C37_RS05255	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0C37_RS05265	COG4214	carbohydrate transport
D0C37_RS05275	COG4213	ABC transporter substrate-binding protein
D0C37_RS05285	COG0395	ABC-type sugar transport system, permease component
D0C37_RS05290	COG1175	transmembrane transport
D0C37_RS05295	COG1653	transport
D0C37_RS05305	COG3321	synthase
D0C37_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS05305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS05305	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS05305	COG0300	oxidoreductase activity
D0C37_RS05315	COG1132	(ABC) transporter
D0C37_RS05325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS05335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0C37_RS05370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0C37_RS05395	COG1120	ATPase activity
D0C37_RS05405	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0C37_RS05430	COG2235	arginine
D0C37_RS05435	COG1320	monovalent cation:proton antiporter activity
D0C37_RS05450	COG0651	ATP synthesis coupled electron transport
D0C37_RS05455	COG1006	Multisubunit Na H antiporter MnhC subunit
D0C37_RS05460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0C37_RS05460	COG2111	Na H antiporter
D0C37_RS05470	COG2124	cytochrome p450
D0C37_RS05500	COG0531	amino acid
D0C37_RS05505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0C37_RS05535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0C37_RS05570	COG1799	cell septum assembly
D0C37_RS05580	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D0C37_RS05595	COG1556	Lactate utilization protein
D0C37_RS05600	COG1139	Iron-sulfur cluster binding protein
D0C37_RS05605	COG0247	lactate metabolic process
D0C37_RS05610	COG1620	l-lactate permease
D0C37_RS05620	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0C37_RS05660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0C37_RS05670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0C37_RS05685	COG1120	ATPase activity
D0C37_RS05690	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS05695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS05705	COG0655	NAD(P)H dehydrogenase (quinone) activity
D0C37_RS05710	COG1733	regulation of RNA biosynthetic process
D0C37_RS05715	COG0789	Transcriptional regulator
D0C37_RS05735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS05740	COG0601	transmembrane transport
D0C37_RS05750	COG0747	negative chemotaxis
D0C37_RS05770	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0C37_RS05780	COG3415	Transposase
D0C37_RS05780	COG2801	Transposase and inactivated derivatives
D0C37_RS05790	COG2936	dipeptidyl-peptidase activity
D0C37_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS05810	COG3540	Alkaline phosphatase
D0C37_RS05820	COG2050	protein possibly involved in aromatic compounds catabolism
D0C37_RS05835	COG0789	Transcriptional regulator
D0C37_RS05845	COG0789	Transcriptional regulator
D0C37_RS05850	COG0640	Transcriptional regulator
D0C37_RS05870	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0C37_RS05920	COG2801	Transposase and inactivated derivatives
D0C37_RS05920	COG3415	Transposase
D0C37_RS05930	COG3226	Transcriptional regulator
D0C37_RS05935	COG0738	Major facilitator superfamily
D0C37_RS05950	COG4213	ABC transporter substrate-binding protein
D0C37_RS05955	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS05960	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS05965	COG1129	ABC transporter
D0C37_RS05970	COG1940	carbohydrate kinase activity
D0C37_RS05970	COG1846	Transcriptional regulator
D0C37_RS05975	COG0252	asparaginase activity
D0C37_RS05985	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS06025	COG0473	3-isopropylmalate dehydrogenase activity
D0C37_RS06040	COG0656	L-ascorbic acid biosynthetic process
D0C37_RS06075	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D0C37_RS06100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D0C37_RS06160	COG3387	PFAM Glycoside hydrolase 15-related
D0C37_RS06195	COG0829	nickel cation binding
D0C37_RS06200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0C37_RS06215	COG0832	Belongs to the urease beta subunit family
D0C37_RS06220	COG0831	urea catabolic process
D0C37_RS06240	COG0395	ABC-type sugar transport system, permease component
D0C37_RS06245	COG1063	alcohol dehydrogenase
D0C37_RS06260	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS06265	COG2197	response regulator
D0C37_RS06275	COG1136	(ABC) transporter
D0C37_RS06285	COG2197	response regulator
D0C37_RS06295	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0C37_RS06305	COG3251	PFAM MbtH domain protein
D0C37_RS06320	COG2175	clavaminate synthase activity
D0C37_RS06370	COG1401	restriction endodeoxyribonuclease activity
D0C37_RS06385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0C37_RS06405	COG2442	InterPro IPR007367
D0C37_RS06440	COG0443	Heat shock 70 kDa protein
D0C37_RS06455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D0C37_RS06460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0C37_RS06465	COG0515	serine threonine protein kinase
D0C37_RS06465	COG2815	serine threonine protein kinase
D0C37_RS06485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0C37_RS06490	COG0531	amino acid
D0C37_RS06495	COG0569	domain protein
D0C37_RS06525	COG1136	(ABC) transporter
D0C37_RS06545	COG0756	dUTP diphosphatase activity
D0C37_RS06570	COG2205	protein histidine kinase activity
D0C37_RS06575	COG0745	RESPONSE REGULATOR receiver
D0C37_RS06580	COG0483	inositol monophosphate 1-phosphatase activity
D0C37_RS06585	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D0C37_RS06635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0C37_RS06645	COG1802	Transcriptional regulator
D0C37_RS06660	COG0612	Peptidase, M16
D0C37_RS06665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0C37_RS06675	COG0366	Alpha amylase catalytic
D0C37_RS06680	COG0395	ABC-type sugar transport system, permease component
D0C37_RS06685	COG1175	transmembrane transport
D0C37_RS06705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0C37_RS06720	COG1309	transcriptional regulator
D0C37_RS06725	COG0187	DNA topoisomerase II activity
D0C37_RS06740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0C37_RS06745	COG1802	Transcriptional regulator
D0C37_RS06785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0C37_RS06800	COG0588	phosphoglycerate mutase activity
D0C37_RS06830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0C37_RS06835	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0C37_RS06840	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0C37_RS06880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0C37_RS06890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0C37_RS06895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0C37_RS06905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0C37_RS06925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0C37_RS06935	COG2205	protein histidine kinase activity
D0C37_RS06950	COG1126	abc transporter atp-binding protein
D0C37_RS06955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0C37_RS06960	COG0765	amino acid transport
D0C37_RS06965	COG0765	amino acid transport
D0C37_RS06970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0C37_RS06995	COG2137	regulation of response to DNA damage stimulus
D0C37_RS07000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0C37_RS07030	COG0628	permease
D0C37_RS07055	COG1201	RNA secondary structure unwinding
D0C37_RS07060	COG0596	Alpha beta hydrolase
D0C37_RS07080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0C37_RS07090	COG0783	Belongs to the Dps family
D0C37_RS07095	COG1396	sequence-specific DNA binding
D0C37_RS07100	COG1058	Belongs to the CinA family
D0C37_RS07100	COG1546	Belongs to the CinA family
D0C37_RS07110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0C37_RS07120	COG1674	ftsk spoiiie
D0C37_RS07130	COG3437	response regulator, receiver
D0C37_RS07130	COG2205	protein histidine kinase activity
D0C37_RS07130	COG3850	Histidine kinase
D0C37_RS07130	COG4999	Histidine kinase
D0C37_RS07140	COG2208	phosphoserine phosphatase activity
D0C37_RS07140	COG2770	Histidine kinase
D0C37_RS07175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D0C37_RS07180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0C37_RS07185	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D0C37_RS07215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0C37_RS07220	COG0612	Peptidase, M16
D0C37_RS07225	COG1185	polyribonucleotide nucleotidyltransferase activity
D0C37_RS07230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0C37_RS07240	COG0455	bacterial-type flagellum organization
D0C37_RS07245	COG0747	negative chemotaxis
D0C37_RS07250	COG0601	transmembrane transport
D0C37_RS07255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS07265	COG4608	Belongs to the ABC transporter superfamily
D0C37_RS07270	COG1357	PFAM Pentapeptide repeats (8 copies)
D0C37_RS07285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0C37_RS07290	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0C37_RS07300	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0C37_RS07315	COG0779	Required for maturation of 30S ribosomal subunits
D0C37_RS07335	COG0442	prolyl-tRNA aminoacylation
D0C37_RS07355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS07360	COG0601	transmembrane transport
D0C37_RS07380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0C37_RS07385	COG0750	zinc metalloprotease
D0C37_RS07390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0C37_RS07395	COG1940	carbohydrate kinase activity
D0C37_RS07400	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS07405	COG2508	Transcriptional regulator
D0C37_RS07435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0C37_RS07440	COG1177	transmembrane transport
D0C37_RS07450	COG3842	ATPase activity
D0C37_RS07460	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS07475	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0C37_RS07495	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS07505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0C37_RS07530	COG3842	ATPase activity
D0C37_RS07545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0C37_RS07550	COG0575	Belongs to the CDS family
D0C37_RS07555	COG0233	cytoplasmic translational termination
D0C37_RS07560	COG0528	UMP kinase activity
D0C37_RS07565	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0C37_RS07570	COG0052	Belongs to the universal ribosomal protein uS2 family
D0C37_RS07585	COG1191	sigma factor activity
D0C37_RS07600	COG0792	nuclease activity
D0C37_RS07615	COG0681	Belongs to the peptidase S26 family
D0C37_RS07620	COG0681	Belongs to the peptidase S26 family
D0C37_RS07625	COG0681	Belongs to the peptidase S26 family
D0C37_RS07635	COG0335	large ribosomal subunit rRNA binding
D0C37_RS07640	COG0336	Belongs to the RNA methyltransferase TrmD family
D0C37_RS07645	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0C37_RS07650	COG1837	Belongs to the UPF0109 family
D0C37_RS07655	COG0228	four-way junction DNA binding
D0C37_RS07670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0C37_RS07680	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D0C37_RS07710	COG0477	Major facilitator Superfamily
D0C37_RS07715	COG1196	nuclear chromosome segregation
D0C37_RS07730	COG1254	Belongs to the acylphosphatase family
D0C37_RS07735	COG2340	Cysteine-rich secretory protein family
D0C37_RS07740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0C37_RS07745	COG0571	ribonuclease III activity
D0C37_RS07750	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D0C37_RS07765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0C37_RS07770	COG0742	ribosomal rna small subunit methyltransferase
D0C37_RS07780	COG1461	Dihydroxyacetone kinase
D0C37_RS07785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0C37_RS07790	COG0351	phosphomethylpyrimidine kinase
D0C37_RS07810	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0C37_RS07815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0C37_RS07825	COG1920	GTP binding
D0C37_RS07835	COG0776	regulation of translation
D0C37_RS07845	COG0066	3-isopropylmalate dehydratase activity
D0C37_RS07850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D0C37_RS07855	COG1414	Transcriptional regulator
D0C37_RS07900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0C37_RS07905	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0C37_RS07920	COG2018	Roadblock/LC7 domain
D0C37_RS07940	COG2018	Roadblock/LC7 domain
D0C37_RS07960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0C37_RS07970	COG2353	YceI-like domain
D0C37_RS08045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0C37_RS08060	COG2957	Belongs to the agmatine deiminase family
D0C37_RS08065	COG0804	urea catabolic process
D0C37_RS08070	COG0831	urea catabolic process
D0C37_RS08070	COG0832	Belongs to the urease beta subunit family
D0C37_RS08080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0C37_RS08085	COG0473	3-isopropylmalate dehydrogenase activity
D0C37_RS08095	COG0575	Belongs to the CDS family
D0C37_RS08110	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS08115	COG0506	proline dehydrogenase activity
D0C37_RS08140	COG2890	protein-(glutamine-N5) methyltransferase activity
D0C37_RS08150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0C37_RS08155	COG0440	acetolactate synthase activity
D0C37_RS08175	COG0667	Aldo Keto reductase
D0C37_RS08180	COG2133	pyrroloquinoline quinone binding
D0C37_RS08185	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D0C37_RS08185	COG1672	PFAM Archaeal ATPase
D0C37_RS08200	COG2409	Drug exporters of the RND superfamily
D0C37_RS08205	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0C37_RS08215	COG0154	amidase activity
D0C37_RS08220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0C37_RS08230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0C37_RS08260	COG0482	sulfurtransferase activity
D0C37_RS08285	COG2860	membrane
D0C37_RS08290	COG4608	Belongs to the ABC transporter superfamily
D0C37_RS08295	COG0444	Belongs to the ABC transporter superfamily
D0C37_RS08300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS08305	COG0601	transmembrane transport
D0C37_RS08310	COG4166	transmembrane transport
D0C37_RS08330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0C37_RS08335	COG0509	glycine decarboxylation via glycine cleavage system
D0C37_RS08340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0C37_RS08345	COG1760	l-serine dehydratase
D0C37_RS08365	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D0C37_RS08370	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D0C37_RS08375	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D0C37_RS08390	COG0477	Major facilitator Superfamily
D0C37_RS08405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0C37_RS08430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0C37_RS08460	COG1376	ErfK ybiS ycfS ynhG family protein
D0C37_RS08485	COG1132	(ABC) transporter
D0C37_RS08490	COG1132	(ABC) transporter
D0C37_RS08510	COG3629	intracellular signal transduction
D0C37_RS08510	COG3903	Transcriptional regulator
D0C37_RS08530	COG0366	Alpha amylase catalytic
D0C37_RS08535	COG0366	Alpha amylase catalytic
D0C37_RS08540	COG3281	Trehalose synthase
D0C37_RS08545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0C37_RS08560	COG1119	ATPase activity
D0C37_RS08590	COG1301	dicarboxylic acid transport
D0C37_RS08595	COG3290	protein histidine kinase activity
D0C37_RS08600	COG4565	transcriptional regulatory protein
D0C37_RS08605	COG0205	6-phosphofructokinase activity
D0C37_RS08610	COG0280	phosphate acetyltransferase
D0C37_RS08610	COG0857	belongs to the CobB CobQ family
D0C37_RS08615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0C37_RS08655	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0C37_RS08655	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0C37_RS08695	COG0596	Alpha beta hydrolase
D0C37_RS08740	COG1335	isochorismatase
D0C37_RS08745	COG2205	protein histidine kinase activity
D0C37_RS08775	COG0829	nickel cation binding
D0C37_RS08780	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0C37_RS08790	COG0804	urea catabolic process
D0C37_RS08795	COG0832	Belongs to the urease beta subunit family
D0C37_RS08795	COG0831	urea catabolic process
D0C37_RS08805	COG0831	urea catabolic process
D0C37_RS08815	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0C37_RS08820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0C37_RS08835	COG0183	Belongs to the thiolase family
D0C37_RS08855	COG1131	(ABC) transporter
D0C37_RS08890	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D0C37_RS08905	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS08920	COG4585	Histidine kinase
D0C37_RS08925	COG2197	response regulator
D0C37_RS08945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0C37_RS08950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0C37_RS08955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0C37_RS08960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0C37_RS08965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0C37_RS08970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0C37_RS08975	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0C37_RS08990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0C37_RS08995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0C37_RS09005	COG2890	protein-(glutamine-N5) methyltransferase activity
D0C37_RS09010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0C37_RS09015	COG0254	rRNA binding
D0C37_RS09020	COG1316	TRANSCRIPTIONal
D0C37_RS09030	COG0083	homoserine kinase activity
D0C37_RS09035	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0C37_RS09040	COG0460	homoserine dehydrogenase
D0C37_RS09045	COG0019	diaminopimelate decarboxylase activity
D0C37_RS09050	COG0018	arginyl-trna synthetase
D0C37_RS09075	COG0210	DNA helicase
D0C37_RS09155	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS09165	COG1191	sigma factor activity
D0C37_RS09170	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0C37_RS09170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0C37_RS09180	COG2267	carboxylic ester hydrolase activity
D0C37_RS09185	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D0C37_RS09200	COG0772	Belongs to the SEDS family
D0C37_RS09205	COG0768	penicillin binding
D0C37_RS09275	COG0726	polysaccharide deacetylase
D0C37_RS09280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0C37_RS09285	COG0477	Major facilitator Superfamily
D0C37_RS09300	COG1595	DNA-templated transcription, initiation
D0C37_RS09310	COG1131	(ABC) transporter
D0C37_RS09330	COG0745	RESPONSE REGULATOR receiver
D0C37_RS09335	COG2205	protein histidine kinase activity
D0C37_RS09340	COG0567	Dehydrogenase, E1 component
D0C37_RS09340	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0C37_RS09370	COG2255	four-way junction helicase activity
D0C37_RS09420	COG0604	alcohol dehydrogenase
D0C37_RS09425	COG0281	malic enzyme
D0C37_RS09435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0C37_RS09445	COG1126	abc transporter atp-binding protein
D0C37_RS09450	COG4106	trans-aconitate 2-methyltransferase activity
D0C37_RS09500	COG0142	geranyltranstransferase activity
D0C37_RS09510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0C37_RS09515	COG1959	2 iron, 2 sulfur cluster binding
D0C37_RS09535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D0C37_RS09550	COG2172	sigma factor antagonist activity
D0C37_RS09565	COG1597	lipid kinase activity
D0C37_RS09580	COG0363	glucosamine-6-phosphate deaminase activity
D0C37_RS09585	COG1472	Belongs to the glycosyl hydrolase 3 family
D0C37_RS09590	COG0395	ABC-type sugar transport system, permease component
D0C37_RS09595	COG1175	transmembrane transport
D0C37_RS09600	COG2182	Extracellular solute-binding protein
D0C37_RS09605	COG2188	Transcriptional regulator
D0C37_RS09610	COG1966	Carbon starvation protein
D0C37_RS09630	COG2124	cytochrome p450
D0C37_RS09640	COG0242	peptide deformylase activity
D0C37_RS09650	COG5662	AntiSigma factor
D0C37_RS09655	COG1595	DNA-templated transcription, initiation
D0C37_RS09665	COG2135	peptidase activity
D0C37_RS09675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0C37_RS09685	COG2076	Multidrug Resistance protein
D0C37_RS09695	COG0483	inositol monophosphate 1-phosphatase activity
D0C37_RS09700	COG0753	catalase activity
D0C37_RS09725	COG1615	UPF0182 protein
D0C37_RS09735	COG3480	Lon protease (S16) C-terminal proteolytic domain
D0C37_RS09790	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D0C37_RS09835	COG0210	DNA helicase
D0C37_RS09925	COG0513	Belongs to the DEAD box helicase family
D0C37_RS09935	COG1432	Conserved Protein
D0C37_RS09940	COG2095	MarC family integral membrane protein
D0C37_RS09945	COG0613	PHP domain protein
D0C37_RS09950	COG2814	Major facilitator Superfamily
D0C37_RS09960	COG0598	Magnesium transport protein CorA
D0C37_RS10000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0C37_RS10005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0C37_RS10015	COG1595	DNA-templated transcription, initiation
D0C37_RS10030	COG1024	Enoyl-CoA hydratase
D0C37_RS10040	COG0519	Catalyzes the synthesis of GMP from XMP
D0C37_RS10065	COG2207	Transcriptional regulator
D0C37_RS10075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0C37_RS10110	COG2912	Transglutaminase-like superfamily
D0C37_RS10120	COG1609	Transcriptional regulator
D0C37_RS10125	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS10135	COG1129	ABC transporter
D0C37_RS10140	COG1879	ABC-type sugar transport system periplasmic component
D0C37_RS10185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0C37_RS10210	COG4608	Belongs to the ABC transporter superfamily
D0C37_RS10220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS10225	COG0601	transmembrane transport
D0C37_RS10235	COG4608	Belongs to the ABC transporter superfamily
D0C37_RS10240	COG0444	Belongs to the ABC transporter superfamily
D0C37_RS10245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS10250	COG0601	transmembrane transport
D0C37_RS10260	COG1217	gtp-binding protein TYPA
D0C37_RS10315	COG1554	hydrolase, family 65, central catalytic
D0C37_RS10375	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS10380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS10390	COG3473	Maleate cis-trans isomerase
D0C37_RS10410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0C37_RS10415	COG0765	amino acid transport
D0C37_RS10420	COG0765	amino acid transport
D0C37_RS10425	COG1126	abc transporter atp-binding protein
D0C37_RS10440	COG0662	Cupin 2, conserved barrel domain protein
D0C37_RS10455	COG3397	chitin binding
D0C37_RS10510	COG0673	inositol 2-dehydrogenase activity
D0C37_RS10515	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0C37_RS10520	COG0706	membrane insertase activity
D0C37_RS10580	COG2733	membrane
D0C37_RS10610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0C37_RS10620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0C37_RS10645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0C37_RS10655	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0C37_RS10660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0C37_RS10665	COG1263	PTS System
D0C37_RS10675	COG1234	tRNA 3'-trailer cleavage
D0C37_RS10695	COG1113	amino acid transport
D0C37_RS10710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D0C37_RS10720	COG1335	isochorismatase
D0C37_RS10760	COG0277	FAD linked oxidase domain protein
D0C37_RS10770	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D0C37_RS10780	COG1174	glycine betaine transport
D0C37_RS10785	COG0517	IMP dehydrogenase activity
D0C37_RS10785	COG1125	glycine betaine transport
D0C37_RS10790	COG1174	glycine betaine transport
D0C37_RS10845	COG2318	DinB family
D0C37_RS10855	COG3344	reverse transcriptase
D0C37_RS10890	COG2318	DinB family
D0C37_RS10905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0C37_RS10920	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D0C37_RS10925	COG0395	ABC-type sugar transport system, permease component
D0C37_RS10930	COG1175	transmembrane transport
D0C37_RS10945	COG1678	Uncharacterized ACR, COG1678
D0C37_RS10950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0C37_RS10955	COG0776	regulation of translation
D0C37_RS10965	COG3973	AAA domain
D0C37_RS10965	COG3973	AAA domain
D0C37_RS11010	COG0583	DNA-binding transcription factor activity
D0C37_RS11025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0C37_RS11030	COG0793	Belongs to the peptidase S41A family
D0C37_RS11040	COG2884	Cell division ATP-binding protein ftsE
D0C37_RS11055	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0C37_RS11060	COG0515	serine threonine protein kinase
D0C37_RS11065	COG0515	serine threonine protein kinase
D0C37_RS11090	COG1716	ATPase activity
D0C37_RS11095	COG1653	transport
D0C37_RS11100	COG1175	transmembrane transport
D0C37_RS11105	COG0395	ABC-type sugar transport system, permease component
D0C37_RS11110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0C37_RS11115	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS11120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0C37_RS11125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0C37_RS11135	COG2226	methyltransferase
D0C37_RS11150	COG2902	Dehydrogenase
D0C37_RS11170	COG0583	DNA-binding transcription factor activity
D0C37_RS11190	COG0653	protein targeting
D0C37_RS11195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0C37_RS11200	COG3214	Protein conserved in bacteria
D0C37_RS11205	COG2197	response regulator
D0C37_RS11210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0C37_RS11220	COG0823	Involved in the tonB-independent uptake of proteins
D0C37_RS11225	COG5002	protein histidine kinase activity
D0C37_RS11230	COG0745	RESPONSE REGULATOR receiver
D0C37_RS11235	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D0C37_RS11255	COG0714	Associated with various cellular activities
D0C37_RS11260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D0C37_RS11300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D0C37_RS11310	COG1482	cell wall glycoprotein biosynthetic process
D0C37_RS11320	COG2835	tetraacyldisaccharide 4'-kinase activity
D0C37_RS11330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0C37_RS11340	COG1620	l-lactate permease
D0C37_RS11380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0C37_RS11385	COG0778	Nitroreductase
D0C37_RS11385	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D0C37_RS11390	COG2226	methyltransferase
D0C37_RS11425	COG1316	TRANSCRIPTIONal
D0C37_RS11435	COG1316	TRANSCRIPTIONal
D0C37_RS11445	COG1316	TRANSCRIPTIONal
D0C37_RS11450	COG3046	protein related to deoxyribodipyrimidine photolyase
D0C37_RS11465	COG0753	catalase activity
D0C37_RS11500	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D0C37_RS11505	COG2197	response regulator
D0C37_RS11510	COG4585	Histidine kinase
D0C37_RS11515	COG1136	(ABC) transporter
D0C37_RS11530	COG2072	flavoprotein involved in K transport
D0C37_RS11555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0C37_RS11570	COG2205	protein histidine kinase activity
D0C37_RS11575	COG0745	RESPONSE REGULATOR receiver
D0C37_RS11580	COG3104	oligopeptide transport
D0C37_RS11590	COG1366	Belongs to the anti-sigma-factor antagonist family
D0C37_RS11595	COG1191	sigma factor activity
D0C37_RS11600	COG1228	amidohydrolase
D0C37_RS11610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0C37_RS11630	COG0395	ABC-type sugar transport system, permease component
D0C37_RS11700	COG2755	lipolytic protein G-D-S-L family
D0C37_RS11705	COG0183	Belongs to the thiolase family
D0C37_RS11730	COG1476	TRANSCRIPTIONal
D0C37_RS11745	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D0C37_RS11755	COG1136	(ABC) transporter
D0C37_RS11760	COG1136	(ABC) transporter
D0C37_RS11760	COG0577	efflux transmembrane transporter activity
D0C37_RS11765	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0C37_RS11770	COG1252	NADH dehydrogenase
D0C37_RS11800	COG0148	phosphopyruvate hydratase activity
D0C37_RS11815	COG2124	cytochrome p450
D0C37_RS11860	COG1733	regulation of RNA biosynthetic process
D0C37_RS11920	COG0477	Major facilitator Superfamily
D0C37_RS11955	COG2267	carboxylic ester hydrolase activity
D0C37_RS11970	COG1316	TRANSCRIPTIONal
D0C37_RS11990	COG0789	Transcriptional regulator
D0C37_RS12015	COG4585	Histidine kinase
D0C37_RS12025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0C37_RS12030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0C37_RS12050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D0C37_RS12055	COG0193	aminoacyl-tRNA hydrolase activity
D0C37_RS12065	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D0C37_RS12085	COG4106	trans-aconitate 2-methyltransferase activity
D0C37_RS12095	COG2197	response regulator
D0C37_RS12100	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0C37_RS12145	COG0488	(ABC) transporter
D0C37_RS12150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0C37_RS12155	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0C37_RS12160	COG0084	hydrolase, TatD family'
D0C37_RS12185	COG2186	Transcriptional regulator
D0C37_RS12275	COG0305	Participates in initiation and elongation during chromosome replication
D0C37_RS12285	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D0C37_RS12340	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0C37_RS12350	COG2409	Drug exporters of the RND superfamily
D0C37_RS12360	COG0793	Belongs to the peptidase S41A family
D0C37_RS12360	COG4946	Tricorn protease homolog
D0C37_RS12370	COG4221	oxidoreductase activity
D0C37_RS12380	COG2072	flavoprotein involved in K transport
D0C37_RS12390	COG0708	Exodeoxyribonuclease III
D0C37_RS12405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D0C37_RS12465	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0C37_RS12465	COG0315	cyclic pyranopterin monophosphate synthase activity
D0C37_RS12470	COG0315	cyclic pyranopterin monophosphate synthase activity
D0C37_RS12480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0C37_RS12485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0C37_RS12495	COG3263	regulation of cellular component size
D0C37_RS12510	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0C37_RS12520	COG1970	mechanosensitive ion channel activity
D0C37_RS12535	COG3191	aminopeptidase activity
D0C37_RS12555	COG3384	dioxygenase
D0C37_RS12560	COG1846	Transcriptional regulator
D0C37_RS12615	COG2050	protein possibly involved in aromatic compounds catabolism
D0C37_RS12625	COG0183	Belongs to the thiolase family
D0C37_RS12630	COG1024	Enoyl-CoA hydratase
D0C37_RS12635	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS12640	COG3396	Phenylacetate-CoA oxygenase
D0C37_RS12645	COG3460	Phenylacetate-CoA oxygenase
D0C37_RS12650	COG3396	Phenylacetate-CoA oxygenase
D0C37_RS12655	COG2151	metal-sulfur cluster biosynthetic enzyme
D0C37_RS12660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0C37_RS12700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0C37_RS12705	COG0191	fructose-bisphosphate aldolase activity
D0C37_RS12710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0C37_RS12735	COG1278	Cold shock
D0C37_RS12820	COG5297	Belongs to the glycosyl hydrolase family 6
D0C37_RS12840	COG0148	phosphopyruvate hydratase activity
D0C37_RS12855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D0C37_RS12895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0C37_RS12930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0C37_RS12930	COG0515	serine threonine protein kinase
D0C37_RS12935	COG1309	transcriptional regulator
D0C37_RS12955	COG2072	flavoprotein involved in K transport
D0C37_RS12960	COG2271	Major facilitator Superfamily
D0C37_RS12980	COG1366	Belongs to the anti-sigma-factor antagonist family
D0C37_RS13070	COG4821	SIS domain
D0C37_RS13080	COG0259	pyridoxamine-phosphate oxidase activity
D0C37_RS13100	COG1024	Enoyl-CoA hydratase
D0C37_RS13115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0C37_RS13145	COG1131	(ABC) transporter
D0C37_RS13185	COG0583	DNA-binding transcription factor activity
D0C37_RS13190	COG0247	lactate metabolic process
D0C37_RS13190	COG0277	FAD linked oxidase domain protein
D0C37_RS13195	COG2205	protein histidine kinase activity
D0C37_RS13215	COG2124	cytochrome p450
D0C37_RS13225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0C37_RS13340	COG0667	Aldo Keto reductase
D0C37_RS13365	COG2252	PERMEase
D0C37_RS13375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0C37_RS13400	COG2814	Major facilitator Superfamily
D0C37_RS13410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0C37_RS13415	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D0C37_RS13420	COG1278	Cold shock
D0C37_RS13430	COG2197	response regulator
D0C37_RS13435	COG1132	(ABC) transporter
D0C37_RS13440	COG1132	(ABC) transporter
D0C37_RS13450	COG0515	serine threonine protein kinase
D0C37_RS13455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0C37_RS13460	COG1120	ATPase activity
D0C37_RS13465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS13470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS13485	COG1295	ribonuclease BN
D0C37_RS13495	COG2124	cytochrome p450
D0C37_RS13550	COG1061	Type III restriction enzyme res subunit
D0C37_RS13565	COG0667	Aldo Keto reductase
D0C37_RS13570	COG0789	Transcriptional regulator
D0C37_RS13605	COG3973	AAA domain
D0C37_RS13660	COG4585	Histidine kinase
D0C37_RS13665	COG2197	response regulator
D0C37_RS13685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0C37_RS13750	COG0406	alpha-ribazole phosphatase activity
D0C37_RS13755	COG1737	Transcriptional regulator
D0C37_RS13760	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0C37_RS13765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0C37_RS13765	COG1263	PTS System
D0C37_RS13775	COG0667	Aldo Keto reductase
D0C37_RS13810	COG1278	Cold shock
D0C37_RS13825	COG0463	Glycosyl transferase, family 2
D0C37_RS13905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0C37_RS13965	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D0C37_RS13990	COG1309	transcriptional regulator
D0C37_RS14005	COG1136	(ABC) transporter
D0C37_RS14040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0C37_RS14060	COG3344	reverse transcriptase
D0C37_RS14185	COG1366	Belongs to the anti-sigma-factor antagonist family
D0C37_RS14190	COG1366	Belongs to the anti-sigma-factor antagonist family
D0C37_RS14195	COG2172	sigma factor antagonist activity
D0C37_RS14220	COG0577	efflux transmembrane transporter activity
D0C37_RS14220	COG1136	(ABC) transporter
D0C37_RS14225	COG0577	efflux transmembrane transporter activity
D0C37_RS14235	COG1902	pentaerythritol trinitrate reductase activity
D0C37_RS14265	COG2409	Drug exporters of the RND superfamily
D0C37_RS14275	COG4585	Histidine kinase
D0C37_RS14280	COG2197	response regulator
D0C37_RS14285	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0C37_RS14290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0C37_RS14310	COG0301	tRNA thio-modification
D0C37_RS14315	COG0501	Belongs to the peptidase M48B family
D0C37_RS14345	COG2186	Transcriptional regulator
D0C37_RS14350	COG2828	Protein conserved in bacteria
D0C37_RS14355	COG2159	amidohydrolase
D0C37_RS14370	COG2814	Major facilitator Superfamily
D0C37_RS14370	COG0477	Major facilitator Superfamily
D0C37_RS14380	COG0739	heme binding
D0C37_RS14410	COG0588	phosphoglycerate mutase activity
D0C37_RS14435	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS14445	COG3103	Sh3 type 3 domain protein
D0C37_RS14445	COG1388	LysM domain
D0C37_RS14445	COG0791	NLP P60 protein
D0C37_RS14560	COG1309	transcriptional regulator
D0C37_RS14580	COG2226	methyltransferase
D0C37_RS14590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0C37_RS14645	COG3344	reverse transcriptase
D0C37_RS14675	COG0789	Transcriptional regulator
D0C37_RS14690	COG1490	D-aminoacyl-tRNA deacylase activity
D0C37_RS14695	COG0354	folic acid binding
D0C37_RS14700	COG0735	belongs to the Fur family
D0C37_RS14705	COG3485	protocatechuate 3,4-dioxygenase
D0C37_RS14745	COG2897	thiosulfate sulfurtransferase activity
D0C37_RS14770	COG0745	RESPONSE REGULATOR receiver
D0C37_RS14775	COG1609	Transcriptional regulator
D0C37_RS14780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0C37_RS14785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0C37_RS14805	COG4214	carbohydrate transport
D0C37_RS14810	COG1129	ABC transporter
D0C37_RS14820	COG1609	Transcriptional regulator
D0C37_RS14825	COG2318	DinB family
D0C37_RS14835	COG2160	L-arabinose isomerase activity
D0C37_RS14840	COG0235	Class ii aldolase
D0C37_RS14855	COG0737	Belongs to the 5'-nucleotidase family
D0C37_RS14860	COG0456	acetyltransferase
D0C37_RS14915	COG4941	Belongs to the sigma-70 factor family
D0C37_RS14920	COG1725	Transcriptional regulator
D0C37_RS14930	COG3842	ATPase activity
D0C37_RS15020	COG1595	DNA-templated transcription, initiation
D0C37_RS15040	COG2814	Major facilitator Superfamily
D0C37_RS15070	COG0596	Alpha beta hydrolase
D0C37_RS15110	COG2318	DinB family
D0C37_RS15115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0C37_RS15160	COG0494	nUDIX hydrolase
D0C37_RS15160	COG0406	alpha-ribazole phosphatase activity
D0C37_RS15180	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0C37_RS15185	COG0306	phosphate transporter
D0C37_RS15195	COG1937	Protein conserved in bacteria
D0C37_RS15205	COG0515	serine threonine protein kinase
D0C37_RS15205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0C37_RS15210	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS15225	COG0671	phosphoesterase, PA-phosphatase related
D0C37_RS15250	COG2318	DinB family
D0C37_RS15260	COG0509	glycine decarboxylation via glycine cleavage system
D0C37_RS15300	COG2208	phosphoserine phosphatase activity
D0C37_RS15300	COG2172	sigma factor antagonist activity
D0C37_RS15300	COG1366	Belongs to the anti-sigma-factor antagonist family
D0C37_RS15315	COG0577	efflux transmembrane transporter activity
D0C37_RS15315	COG1136	(ABC) transporter
D0C37_RS15340	COG2124	cytochrome p450
D0C37_RS15360	COG0798	PFAM Bile acid sodium symporter
D0C37_RS15365	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0C37_RS15380	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D0C37_RS15395	COG1335	isochorismatase
D0C37_RS15405	COG2197	response regulator
D0C37_RS15410	COG4585	Histidine kinase
D0C37_RS15415	COG0702	epimerase
D0C37_RS15425	COG3844	kynureninase activity
D0C37_RS15445	COG0477	Major facilitator Superfamily
D0C37_RS15450	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0C37_RS15455	COG0191	fructose-bisphosphate aldolase activity
D0C37_RS15460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0C37_RS15475	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D0C37_RS15505	COG2378	regulation of single-species biofilm formation
D0C37_RS15520	COG0477	Major facilitator Superfamily
D0C37_RS15550	COG0789	Transcriptional regulator
D0C37_RS15555	COG0484	heat shock protein binding
D0C37_RS15560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0C37_RS15565	COG0443	Heat shock 70 kDa protein
D0C37_RS15600	COG1725	Transcriptional regulator
D0C37_RS15605	COG1131	(ABC) transporter
D0C37_RS15625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0C37_RS15630	COG1120	ATPase activity
D0C37_RS15635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS15670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS15670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS15705	COG1695	Transcriptional regulator
D0C37_RS15755	COG1857	crispr-associated protein
D0C37_RS15770	COG2814	Major facilitator Superfamily
D0C37_RS15800	COG1401	restriction endodeoxyribonuclease activity
D0C37_RS15810	COG0717	Belongs to the dCTP deaminase family
D0C37_RS15850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D0C37_RS15855	COG2181	nitrate reductase activity
D0C37_RS15855	COG0247	lactate metabolic process
D0C37_RS15890	COG0477	Major facilitator Superfamily
D0C37_RS15910	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0C37_RS15950	COG1937	Protein conserved in bacteria
D0C37_RS15955	COG2268	Band 7 protein
D0C37_RS15970	COG1316	TRANSCRIPTIONal
D0C37_RS16010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0C37_RS16020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0C37_RS16035	COG1741	Belongs to the pirin family
D0C37_RS16045	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS16065	COG1362	aminopeptidase activity
D0C37_RS16130	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0C37_RS16135	COG0022	dehydrogenase e1 component
D0C37_RS16150	COG0515	serine threonine protein kinase
D0C37_RS16155	COG0515	serine threonine protein kinase
D0C37_RS16180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0C37_RS16185	COG0303	'Molybdopterin
D0C37_RS16210	COG1522	sequence-specific DNA binding
D0C37_RS16250	COG1733	regulation of RNA biosynthetic process
D0C37_RS16255	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0C37_RS16265	COG1716	ATPase activity
D0C37_RS16270	COG1716	ATPase activity
D0C37_RS16295	COG0515	serine threonine protein kinase
D0C37_RS16300	COG3764	Sortase (surface protein transpeptidase)
D0C37_RS16305	COG3764	Sortase (surface protein transpeptidase)
D0C37_RS16330	COG0705	Rhomboid family
D0C37_RS16350	COG1309	transcriptional regulator
D0C37_RS16365	COG0515	serine threonine protein kinase
D0C37_RS16400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0C37_RS16405	COG0187	DNA topoisomerase II activity
D0C37_RS16410	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D0C37_RS16415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0C37_RS16420	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D0C37_RS16425	COG0592	DNA-directed DNA polymerase activity
D0C37_RS16435	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0C37_RS16440	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D0C37_RS16445	COG0594	ribonuclease P activity
D0C37_RS16450	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0C37_RS16455	COG0706	membrane insertase activity
D0C37_RS16465	COG0357	Ribosomal RNA small subunit methyltransferase G
D0C37_RS16470	COG1192	Involved in chromosome partitioning
D0C37_RS16485	COG3118	belongs to the thioredoxin family
D0C37_RS16490	COG0492	ferredoxin-NADP+ reductase activity
D0C37_RS16500	COG1595	DNA-templated transcription, initiation
D0C37_RS16505	COG2815	serine threonine protein kinase
D0C37_RS16505	COG0515	serine threonine protein kinase
D0C37_RS16520	COG0617	tRNA 3'-terminal CCA addition
D0C37_RS16545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0C37_RS16570	COG0360	Binds together with S18 to 16S ribosomal RNA
D0C37_RS16575	COG0629	single-stranded DNA binding
D0C37_RS16580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0C37_RS16585	COG0359	binds to the 23S rRNA
D0C37_RS16595	COG0305	Participates in initiation and elongation during chromosome replication
D0C37_RS16600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0C37_RS16605	COG0110	maltose O-acetyltransferase activity
D0C37_RS16645	COG0626	cystathionine gamma-synthase activity
D0C37_RS16650	COG1950	PFAM Membrane protein of
D0C37_RS16655	COG0662	Cupin 2, conserved barrel domain protein
D0C37_RS16680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0C37_RS16695	COG1609	Transcriptional regulator
D0C37_RS16700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0C37_RS16705	COG1271	oxidase subunit
D0C37_RS16710	COG1294	oxidase, subunit
D0C37_RS16715	COG4988	ABC transporter
D0C37_RS16725	COG1196	nuclear chromosome segregation
D0C37_RS16725	COG0739	heme binding
D0C37_RS16725	COG0741	lytic transglycosylase activity
D0C37_RS16730	COG0561	phosphatase activity
D0C37_RS16770	COG0561	phosphatase activity
D0C37_RS16775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0C37_RS16785	COG2837	iron assimilation
D0C37_RS16800	COG1999	signal sequence binding
D0C37_RS16820	COG0006	proline dipeptidase activity
D0C37_RS16835	COG0653	protein targeting
D0C37_RS16850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0C37_RS16870	COG1595	DNA-templated transcription, initiation
D0C37_RS16875	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS16910	COG0745	RESPONSE REGULATOR receiver
D0C37_RS16920	COG0477	Major facilitator Superfamily
D0C37_RS16940	COG0477	Major facilitator Superfamily
D0C37_RS16955	COG1191	sigma factor activity
D0C37_RS16960	COG1191	sigma factor activity
D0C37_RS16995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0C37_RS17000	COG2826	transposase and inactivated derivatives, IS30 family
D0C37_RS17080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0C37_RS17120	COG0151	Belongs to the GarS family
D0C37_RS17135	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0C37_RS17145	COG2197	response regulator
D0C37_RS17180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0C37_RS17185	COG0047	phosphoribosylformylglycinamidine synthase activity
D0C37_RS17190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0C37_RS17205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0C37_RS17240	COG1643	Atp-dependent helicase
D0C37_RS17280	COG0513	Belongs to the DEAD box helicase family
D0C37_RS17310	COG0542	response to heat
D0C37_RS17320	COG2261	transglycosylase associated protein
D0C37_RS17340	COG0667	Aldo Keto reductase
D0C37_RS17350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0C37_RS17355	COG0579	oxidoreductase
D0C37_RS17360	COG2801	Transposase and inactivated derivatives
D0C37_RS17360	COG3415	Transposase
D0C37_RS17395	COG0366	Alpha amylase catalytic
D0C37_RS17395	COG1470	cell adhesion involved in biofilm formation
D0C37_RS17485	COG4552	Acetyltransferase involved in intracellular survival and related
D0C37_RS17505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0C37_RS17555	COG2197	response regulator
D0C37_RS17570	COG0666	response to abiotic stimulus
D0C37_RS17645	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0C37_RS17650	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0C37_RS17745	COG2318	DinB family
D0C37_RS17765	COG1136	(ABC) transporter
D0C37_RS17765	COG0577	efflux transmembrane transporter activity
D0C37_RS17790	COG1408	metallophosphoesterase
D0C37_RS17815	COG0003	Pfam Anion-transporting ATPase
D0C37_RS17825	COG0251	oxidation-reduction process
D0C37_RS17835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0C37_RS17865	COG2267	carboxylic ester hydrolase activity
D0C37_RS17875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D0C37_RS17880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0C37_RS17885	COG0659	secondary active sulfate transmembrane transporter activity
D0C37_RS17945	COG1205	dead DEAH box helicase
D0C37_RS17945	COG1111	helicase
D0C37_RS17950	COG1366	Belongs to the anti-sigma-factor antagonist family
D0C37_RS17965	COG2890	protein-(glutamine-N5) methyltransferase activity
D0C37_RS17975	COG1754	DNA topoisomerase type I activity
D0C37_RS17975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0C37_RS17980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0C37_RS18045	COG1309	transcriptional regulator
D0C37_RS18055	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS18075	COG0789	Transcriptional regulator
D0C37_RS18085	COG0596	Alpha beta hydrolase
D0C37_RS18095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0C37_RS18100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D0C37_RS18120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0C37_RS18120	COG0825	malonyl-CoA metabolic process
D0C37_RS18125	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS18135	COG2186	Transcriptional regulator
D0C37_RS18155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0C37_RS18165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0C37_RS18180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0C37_RS18235	COG0494	nUDIX hydrolase
D0C37_RS18240	COG1252	NADH dehydrogenase
D0C37_RS18255	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS18260	COG0640	Transcriptional regulator
D0C37_RS18270	COG1316	TRANSCRIPTIONal
D0C37_RS18275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0C37_RS18290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0C37_RS18315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS18320	COG1120	ATPase activity
D0C37_RS18325	COG0783	Belongs to the Dps family
D0C37_RS18350	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0C37_RS18365	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0C37_RS18370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D0C37_RS18395	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D0C37_RS18440	COG3344	reverse transcriptase
D0C37_RS18465	COG1569	PIN domain
D0C37_RS18470	COG3311	Transcriptional regulator
D0C37_RS18515	COG2076	Multidrug Resistance protein
D0C37_RS18525	COG5002	protein histidine kinase activity
D0C37_RS18530	COG0745	RESPONSE REGULATOR receiver
D0C37_RS18545	COG1329	Transcriptional regulator
D0C37_RS18550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0C37_RS18555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0C37_RS18575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS18590	COG0215	cysteine-tRNA ligase activity
D0C37_RS18605	COG1253	flavin adenine dinucleotide binding
D0C37_RS18615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0C37_RS18625	COG3842	ATPase activity
D0C37_RS18665	COG2208	phosphoserine phosphatase activity
D0C37_RS18665	COG2770	Histidine kinase
D0C37_RS18700	COG1278	Cold shock
D0C37_RS18705	COG0513	Belongs to the DEAD box helicase family
D0C37_RS18725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0C37_RS18725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0C37_RS18755	COG1289	transmembrane transporter activity
D0C37_RS18780	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS18785	COG2318	DinB family
D0C37_RS18795	COG0655	NAD(P)H dehydrogenase (quinone) activity
D0C37_RS18800	COG0789	Transcriptional regulator
D0C37_RS18805	COG0586	Pfam SNARE associated Golgi protein
D0C37_RS18815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D0C37_RS18820	COG2027	D-alanyl-D-alanine carboxypeptidase
D0C37_RS18830	COG0037	tRNA processing
D0C37_RS18845	COG0302	gtp cyclohydrolase
D0C37_RS18860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0C37_RS18875	COG1125	glycine betaine transport
D0C37_RS18875	COG0517	IMP dehydrogenase activity
D0C37_RS18880	COG1174	glycine betaine transport
D0C37_RS18885	COG1174	glycine betaine transport
D0C37_RS18890	COG1732	Glycine betaine
D0C37_RS18920	COG0649	NAD binding
D0C37_RS18935	COG2197	response regulator
D0C37_RS18950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0C37_RS18955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0C37_RS18965	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D0C37_RS18985	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0C37_RS19015	COG0739	heme binding
D0C37_RS19020	COG2205	protein histidine kinase activity
D0C37_RS19025	COG0745	RESPONSE REGULATOR receiver
D0C37_RS19035	COG1595	DNA-templated transcription, initiation
D0C37_RS19045	COG0671	phosphoesterase, PA-phosphatase related
D0C37_RS19055	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D0C37_RS19095	COG0248	Ppx GppA phosphatase
D0C37_RS19105	COG1082	Xylose isomerase domain protein TIM barrel
D0C37_RS19110	COG1309	transcriptional regulator
D0C37_RS19115	COG0129	dihydroxy-acid dehydratase activity
D0C37_RS19125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0C37_RS19145	COG0842	Transport permease protein
D0C37_RS19145	COG1129	ABC transporter
D0C37_RS19155	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0C37_RS19160	COG0180	Tryptophanyl-tRNA synthetase
D0C37_RS19195	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0C37_RS19225	COG4552	Acetyltransferase involved in intracellular survival and related
D0C37_RS19250	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D0C37_RS19255	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0C37_RS19260	COG0181	hydroxymethylbilane synthase activity
D0C37_RS19265	COG1648	precorrin-2 dehydrogenase activity
D0C37_RS19265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0C37_RS19270	COG0113	porphobilinogen synthase activity
D0C37_RS19295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0C37_RS19300	COG0018	arginyl-trna synthetase
D0C37_RS19305	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D0C37_RS19345	COG1690	Belongs to the RtcB family
D0C37_RS19350	COG0659	secondary active sulfate transmembrane transporter activity
D0C37_RS19400	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0C37_RS19405	COG0406	alpha-ribazole phosphatase activity
D0C37_RS19430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0C37_RS19435	COG0785	Cytochrome C biogenesis protein
D0C37_RS19445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0C37_RS19460	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0C37_RS19470	COG0163	prenyltransferase activity
D0C37_RS19480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D0C37_RS19495	COG1301	dicarboxylic acid transport
D0C37_RS19510	COG1131	(ABC) transporter
D0C37_RS19515	COG3559	Exporter of polyketide antibiotics
D0C37_RS19565	COG0183	Belongs to the thiolase family
D0C37_RS19575	COG1278	Cold shock
D0C37_RS19580	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D0C37_RS19585	COG1674	ftsk spoiiie
D0C37_RS19710	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D0C37_RS19760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D0C37_RS19770	COG2226	methyltransferase
D0C37_RS19795	COG2154	pterin-4-alpha-carbinolamine dehydratase
D0C37_RS19810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS19815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS19820	COG0649	NAD binding
D0C37_RS19830	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D0C37_RS19835	COG1034	ATP synthesis coupled electron transport
D0C37_RS19840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0C37_RS19845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS19850	COG0839	Belongs to the complex I subunit 6 family
D0C37_RS19855	COG0713	ATP synthesis coupled electron transport
D0C37_RS19860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0C37_RS19870	COG1007	ATP synthesis coupled electron transport
D0C37_RS19875	COG0514	ATP-dependent DNA helicase (RecQ)
D0C37_RS19890	COG0561	phosphatase activity
D0C37_RS19915	COG3104	oligopeptide transport
D0C37_RS19920	COG0142	geranyltranstransferase activity
D0C37_RS19965	COG0488	(ABC) transporter
D0C37_RS19975	COG0702	epimerase
D0C37_RS19980	COG1733	regulation of RNA biosynthetic process
D0C37_RS19985	COG1013	pyruvate-flavodoxin oxidoreductase activity
D0C37_RS19990	COG0674	pyruvate-flavodoxin oxidoreductase activity
D0C37_RS19990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D0C37_RS19995	COG2197	response regulator
D0C37_RS20000	COG4585	Histidine kinase
D0C37_RS20010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS20015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS20020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS20025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D0C37_RS20030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D0C37_RS20035	COG0839	Belongs to the complex I subunit 6 family
D0C37_RS20040	COG0713	ATP synthesis coupled electron transport
D0C37_RS20045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0C37_RS20055	COG1007	ATP synthesis coupled electron transport
D0C37_RS20060	COG0501	Belongs to the peptidase M48B family
D0C37_RS20065	COG3304	Inner membrane component domain
D0C37_RS20070	COG2261	transglycosylase associated protein
D0C37_RS20075	COG1666	GTP binding
D0C37_RS20085	COG0702	epimerase
D0C37_RS20090	COG0402	S-adenosylhomocysteine deaminase activity
D0C37_RS20105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0C37_RS20110	COG2030	dehydratase
D0C37_RS20120	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0C37_RS20130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0C37_RS20135	COG0436	Aminotransferase
D0C37_RS20160	COG0081	regulation of translation
D0C37_RS20170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0C37_RS20175	COG0222	ribosome binding
D0C37_RS20185	COG0085	RNA polymerase activity
D0C37_RS20190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0C37_RS20225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D0C37_RS20230	COG0049	tRNA binding
D0C37_RS20235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0C37_RS20255	COG3385	transposase activity
D0C37_RS20275	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D0C37_RS20285	COG0051	transcription antitermination factor activity, RNA binding
D0C37_RS20290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0C37_RS20295	COG0088	Forms part of the polypeptide exit tunnel
D0C37_RS20300	COG0089	rRNA binding
D0C37_RS20305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0C37_RS20310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0C37_RS20315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0C37_RS20320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0C37_RS20325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0C37_RS20330	COG0255	Belongs to the universal ribosomal protein uL29 family
D0C37_RS20335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0C37_RS20340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0C37_RS20345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D0C37_RS20350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0C37_RS20355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0C37_RS20365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0C37_RS20370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0C37_RS20375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0C37_RS20380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D0C37_RS20385	COG1841	ribosomal large subunit assembly
D0C37_RS20390	COG0200	Binds to the 23S rRNA
D0C37_RS20395	COG0201	protein transport
D0C37_RS20400	COG0563	adenylate kinase activity
D0C37_RS20415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0C37_RS20420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0C37_RS20425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0C37_RS20430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0C37_RS20440	COG0203	ribosomal protein L17
D0C37_RS20445	COG0101	tRNA pseudouridine synthase activity
D0C37_RS20455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0C37_RS20460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0C37_RS20465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0C37_RS20470	COG1072	(Pantothenic acid kinase))
D0C37_RS20485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0C37_RS20495	COG4977	sequence-specific DNA binding
D0C37_RS20510	COG0736	holo-[acyl-carrier-protein] synthase activity
D0C37_RS20570	COG1554	hydrolase, family 65, central catalytic
D0C37_RS20580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0C37_RS20590	COG0802	atpase or kinase
D0C37_RS20615	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0C37_RS20650	COG0726	polysaccharide deacetylase
D0C37_RS20665	COG4221	oxidoreductase activity
D0C37_RS20670	COG0583	DNA-binding transcription factor activity
D0C37_RS20680	COG2197	response regulator
D0C37_RS20685	COG1595	DNA-templated transcription, initiation
D0C37_RS20695	COG0516	GMP reductase activity
D0C37_RS20705	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0C37_RS20735	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS20755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0C37_RS20755	COG0519	Catalyzes the synthesis of GMP from XMP
D0C37_RS20770	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS20810	COG2197	response regulator
D0C37_RS20815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0C37_RS20850	COG3973	AAA domain
D0C37_RS20885	COG1228	amidohydrolase
D0C37_RS20950	COG2066	Belongs to the glutaminase family
D0C37_RS20955	COG0739	heme binding
D0C37_RS20960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0C37_RS20965	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0C37_RS20965	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D0C37_RS20980	COG0714	Associated with various cellular activities
D0C37_RS20985	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D0C37_RS20990	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D0C37_RS20995	COG0045	succinate-CoA ligase (ADP-forming) activity
D0C37_RS21025	COG0138	bifunctional purine biosynthesis protein purh
D0C37_RS21035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0C37_RS21060	COG0039	L-malate dehydrogenase activity
D0C37_RS21070	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS21080	COG0517	IMP dehydrogenase activity
D0C37_RS21080	COG4175	Glycine betaine
D0C37_RS21110	COG0395	ABC-type sugar transport system, permease component
D0C37_RS21115	COG1175	transmembrane transport
D0C37_RS21135	COG2362	D-Aminopeptidase
D0C37_RS21140	COG1609	Transcriptional regulator
D0C37_RS21150	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0C37_RS21155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0C37_RS21165	COG0754	glutathionylspermidine amidase activity
D0C37_RS21180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0C37_RS21225	COG0180	Tryptophanyl-tRNA synthetase
D0C37_RS21275	COG1686	Belongs to the peptidase S11 family
D0C37_RS21285	COG1408	metallophosphoesterase
D0C37_RS21335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0C37_RS21340	COG1053	succinate dehydrogenase
D0C37_RS21350	COG2009	succinate dehydrogenase
D0C37_RS21390	COG1215	transferase activity, transferring glycosyl groups
D0C37_RS21395	COG1595	DNA-templated transcription, initiation
D0C37_RS21425	COG1216	Glycosyl transferase, family 2
D0C37_RS21435	COG1083	cytidylyl-transferase
D0C37_RS21440	COG2089	acid synthase
D0C37_RS21450	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D0C37_RS21450	COG1473	amidohydrolase
D0C37_RS21495	COG1744	ABC transporter substrate-binding protein PnrA-like
D0C37_RS21500	COG3845	ABC transporter
D0C37_RS21505	COG4603	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS21510	COG1079	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS21550	COG2814	Major facilitator Superfamily
D0C37_RS21555	COG0583	DNA-binding transcription factor activity
D0C37_RS21580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0C37_RS21605	COG2205	protein histidine kinase activity
D0C37_RS21610	COG0745	RESPONSE REGULATOR receiver
D0C37_RS21615	COG1595	DNA-templated transcription, initiation
D0C37_RS21655	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS21670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0C37_RS21705	COG4770	biotin carboxylase activity
D0C37_RS21730	COG0424	maF-like protein
D0C37_RS21740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0C37_RS21750	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D0C37_RS21755	COG1024	Enoyl-CoA hydratase
D0C37_RS21765	COG2986	histidine ammonia-lyase
D0C37_RS21785	COG1136	(ABC) transporter
D0C37_RS21790	COG1064	alcohol dehydrogenase
D0C37_RS21795	COG2318	DinB family
D0C37_RS21820	COG2255	four-way junction helicase activity
D0C37_RS21825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0C37_RS21840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0C37_RS21850	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0C37_RS21885	COG2267	carboxylic ester hydrolase activity
D0C37_RS21890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0C37_RS21895	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0C37_RS21920	COG1331	Highly conserved protein containing a thioredoxin domain
D0C37_RS21940	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D0C37_RS21970	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D0C37_RS21985	COG1414	Transcriptional regulator
D0C37_RS21990	COG0251	oxidation-reduction process
D0C37_RS22065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0C37_RS22100	COG2894	cell division
D0C37_RS22130	COG2197	response regulator
D0C37_RS22165	COG2814	Major facilitator Superfamily
D0C37_RS22170	COG0656	L-ascorbic acid biosynthetic process
D0C37_RS22175	COG2304	oxidoreductase activity
D0C37_RS22185	COG3548	integral membrane protein
D0C37_RS22205	COG0667	Aldo Keto reductase
D0C37_RS22210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0C37_RS22215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0C37_RS22235	COG0450	alkyl hydroperoxide reductase
D0C37_RS22240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0C37_RS22250	COG1136	(ABC) transporter
D0C37_RS22270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0C37_RS22285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0C37_RS22295	COG0114	fumarate hydratase activity
D0C37_RS22310	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D0C37_RS22310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D0C37_RS22335	COG0515	serine threonine protein kinase
D0C37_RS22360	COG0778	Nitroreductase
D0C37_RS22365	COG1722	exodeoxyribonuclease VII activity
D0C37_RS22370	COG1570	exodeoxyribonuclease VII activity
D0C37_RS22380	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0C37_RS22395	COG0012	GTP binding
D0C37_RS22415	COG0406	alpha-ribazole phosphatase activity
D0C37_RS22440	COG0745	RESPONSE REGULATOR receiver
D0C37_RS22490	COG0765	amino acid transport
D0C37_RS22495	COG0765	amino acid transport
D0C37_RS22505	COG1126	abc transporter atp-binding protein
D0C37_RS22510	COG1053	succinate dehydrogenase
D0C37_RS22520	COG1802	Transcriptional regulator
D0C37_RS22530	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D0C37_RS22535	COG4977	sequence-specific DNA binding
D0C37_RS22550	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0C37_RS22570	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D0C37_RS22590	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS22600	COG3655	Transcriptional regulator
D0C37_RS22665	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS22680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0C37_RS22685	COG1309	transcriptional regulator
D0C37_RS22695	COG1946	Acyl-CoA thioesterase
D0C37_RS22735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0C37_RS22745	COG3960	tartronate-semialdehyde synthase activity
D0C37_RS22765	COG1472	Belongs to the glycosyl hydrolase 3 family
D0C37_RS22770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0C37_RS22815	COG3718	enzyme involved in inositol metabolism
D0C37_RS22820	COG3962	Belongs to the TPP enzyme family
D0C37_RS22855	COG1131	(ABC) transporter
D0C37_RS22880	COG3629	intracellular signal transduction
D0C37_RS22880	COG3903	Transcriptional regulator
D0C37_RS22950	COG0629	single-stranded DNA binding
D0C37_RS22995	COG1136	(ABC) transporter
D0C37_RS23020	COG0667	Aldo Keto reductase
D0C37_RS23025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D0C37_RS23055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0C37_RS23075	COG1486	melibiose metabolic process
D0C37_RS23085	COG0668	transmembrane transport
D0C37_RS23100	COG3525	Glycosyl hydrolase, family 20, catalytic domain
D0C37_RS23120	COG0583	DNA-binding transcription factor activity
D0C37_RS23145	COG0582	viral genome integration into host DNA
D0C37_RS23160	COG1674	ftsk spoiiie
D0C37_RS23175	COG2188	Transcriptional regulator
D0C37_RS23230	COG4266	Belongs to the allantoicase family
D0C37_RS23265	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D0C37_RS23270	COG0076	glutamate decarboxylase activity
D0C37_RS23275	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0C37_RS23280	COG1113	amino acid transport
D0C37_RS23285	COG1113	amino acid transport
D0C37_RS23290	COG1268	BioY protein
D0C37_RS23295	COG1113	amino acid transport
D0C37_RS23310	COG4552	Acetyltransferase involved in intracellular survival and related
D0C37_RS23320	COG0475	glutathione-regulated potassium exporter activity
D0C37_RS23325	COG3594	Acyltransferase
D0C37_RS23345	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0C37_RS23350	COG0740	serine-type endopeptidase activity
D0C37_RS23355	COG0740	serine-type endopeptidase activity
D0C37_RS23360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0C37_RS23375	COG0525	valine-tRNA ligase activity
D0C37_RS23380	COG0285	dihydrofolate synthase activity
D0C37_RS23390	COG0105	UTP biosynthetic process
D0C37_RS23400	COG1077	Cell shape determining protein MreB Mrl
D0C37_RS23420	COG0772	Belongs to the SEDS family
D0C37_RS23450	COG1530	ribonuclease E activity
D0C37_RS23455	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0C37_RS23460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D0C37_RS23465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0C37_RS23485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0C37_RS23495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0C37_RS23515	COG0501	Belongs to the peptidase M48B family
D0C37_RS23520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0C37_RS23530	COG0799	negative regulation of ribosome biogenesis
D0C37_RS23535	COG0588	phosphoglycerate mutase activity
D0C37_RS23560	COG0495	leucyl-tRNA aminoacylation
D0C37_RS23570	COG1307	EDD domain protein, DegV family
D0C37_RS23575	COG1555	photosystem II stabilization
D0C37_RS23585	COG2353	YceI-like domain
D0C37_RS23600	COG0268	Binds directly to 16S ribosomal RNA
D0C37_RS23605	COG0481	GTPase activity
D0C37_RS23640	COG0484	heat shock protein binding
D0C37_RS23655	COG4946	Tricorn protease homolog
D0C37_RS23655	COG0793	Belongs to the peptidase S41A family
D0C37_RS23665	COG0537	adenosine 5'-monophosphoramidase activity
D0C37_RS23670	COG1234	tRNA 3'-trailer cleavage
D0C37_RS23690	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D0C37_RS23695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D0C37_RS23720	COG1486	melibiose metabolic process
D0C37_RS23725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0C37_RS23745	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0C37_RS23755	COG2315	Protein conserved in bacteria
D0C37_RS23765	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0C37_RS23780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0C37_RS23790	COG1381	Involved in DNA repair and RecF pathway recombination
D0C37_RS23795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0C37_RS23805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0C37_RS23810	COG1121	(ABC) transporter
D0C37_RS23820	COG0423	glycine-tRNA ligase activity
D0C37_RS23900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0C37_RS23915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0C37_RS23920	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D0C37_RS23930	COG3467	pyridoxamine 5'-phosphate
D0C37_RS23940	COG0151	Belongs to the GarS family
D0C37_RS23955	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D0C37_RS23960	COG1846	Transcriptional regulator
D0C37_RS23960	COG1940	carbohydrate kinase activity
D0C37_RS23975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0C37_RS23975	COG0574	Belongs to the PEP-utilizing enzyme family
D0C37_RS23990	COG1324	tolerance protein
D0C37_RS24000	COG0829	nickel cation binding
D0C37_RS24005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0C37_RS24010	COG0830	nickel cation binding
D0C37_RS24015	COG0804	urea catabolic process
D0C37_RS24020	COG0832	Belongs to the urease beta subunit family
D0C37_RS24025	COG0831	urea catabolic process
D0C37_RS24035	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS24040	COG2226	methyltransferase
D0C37_RS24045	COG0736	holo-[acyl-carrier-protein] synthase activity
D0C37_RS24050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0C37_RS24070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0C37_RS24075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0C37_RS24140	COG1070	Carbohydrate kinase
D0C37_RS24160	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0C37_RS24165	COG0358	DNA primase activity
D0C37_RS24175	COG3290	protein histidine kinase activity
D0C37_RS24180	COG4565	transcriptional regulatory protein
D0C37_RS24185	COG2851	Citrate transporter
D0C37_RS24200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D0C37_RS24220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS24240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0C37_RS24250	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS24265	COG2890	protein-(glutamine-N5) methyltransferase activity
D0C37_RS24280	COG1077	Cell shape determining protein MreB Mrl
D0C37_RS24305	COG2130	NADP-dependent
D0C37_RS24310	COG1764	response to oxidative stress
D0C37_RS24340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0C37_RS24345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0C37_RS24350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0C37_RS24365	COG1741	Belongs to the pirin family
D0C37_RS24380	COG0789	Transcriptional regulator
D0C37_RS24385	COG0667	Aldo Keto reductase
D0C37_RS24400	COG2197	response regulator
D0C37_RS24405	COG4585	Histidine kinase
D0C37_RS24430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0C37_RS24480	COG1358	cellular component organization or biogenesis
D0C37_RS24495	COG0586	Pfam SNARE associated Golgi protein
D0C37_RS24615	COG1657	PFAM Prenyltransferase squalene oxidase
D0C37_RS24625	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS24655	COG0477	Major facilitator Superfamily
D0C37_RS24660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0C37_RS24665	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS24680	COG2197	response regulator
D0C37_RS24685	COG0346	lactoylglutathione lyase activity
D0C37_RS24690	COG4585	Histidine kinase
D0C37_RS24700	COG1131	(ABC) transporter
D0C37_RS24710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0C37_RS24725	COG0800	Aldolase
D0C37_RS24730	COG3022	response to hydroperoxide
D0C37_RS24770	COG1733	regulation of RNA biosynthetic process
D0C37_RS24790	COG2226	methyltransferase
D0C37_RS24795	COG0384	phenazine biosynthesis protein PhzF
D0C37_RS24805	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS24815	COG0076	glutamate decarboxylase activity
D0C37_RS24825	COG2814	Major facilitator Superfamily
D0C37_RS24830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0C37_RS24840	COG1834	amidinotransferase
D0C37_RS24860	COG1120	ATPase activity
D0C37_RS24865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0C37_RS24870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0C37_RS24915	COG1994	Peptidase M50
D0C37_RS24920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0C37_RS24935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0C37_RS24935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0C37_RS24940	COG2132	Multicopper oxidase
D0C37_RS24960	COG0174	glutamine synthetase
D0C37_RS25000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D0C37_RS25020	COG1228	amidohydrolase
D0C37_RS25035	COG1609	Transcriptional regulator
D0C37_RS25040	COG2182	Extracellular solute-binding protein
D0C37_RS25045	COG1175	transmembrane transport
D0C37_RS25050	COG0395	ABC-type sugar transport system, permease component
D0C37_RS25055	COG0366	Alpha amylase catalytic
D0C37_RS25075	COG0456	acetyltransferase
D0C37_RS25075	COG0454	-acetyltransferase
D0C37_RS25080	COG1309	transcriptional regulator
D0C37_RS25105	COG0745	RESPONSE REGULATOR receiver
D0C37_RS25135	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS25175	COG1309	transcriptional regulator
D0C37_RS25210	COG3547	Transposase (IS116 IS110 IS902 family)
D0C37_RS25230	COG2326	polyphosphate kinase activity
D0C37_RS25240	COG2376	Dihydroxyacetone kinase
D0C37_RS25250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0C37_RS25265	COG3415	Transposase
D0C37_RS25265	COG2801	Transposase and inactivated derivatives
D0C37_RS25290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0C37_RS25295	COG0321	lipoyl(octanoyl) transferase activity
D0C37_RS25330	COG4221	oxidoreductase activity
D0C37_RS25345	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D0C37_RS25355	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0C37_RS25360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0C37_RS25365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0C37_RS25370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D0C37_RS25380	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D0C37_RS25425	COG2197	response regulator
D0C37_RS25430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0C37_RS25435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0C37_RS25460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0C37_RS25465	COG1104	cysteine desulfurase activity
D0C37_RS25470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0C37_RS25475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0C37_RS25485	COG1376	ErfK ybiS ycfS ynhG family protein
D0C37_RS25495	COG1845	cytochrome c oxidase, subunit III
D0C37_RS25500	COG2010	Cytochrome c
D0C37_RS25505	COG0723	plastoquinol--plastocyanin reductase activity
D0C37_RS25510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0C37_RS25515	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0C37_RS25520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0C37_RS25525	COG1929	Belongs to the glycerate kinase type-1 family
D0C37_RS25535	COG0745	RESPONSE REGULATOR receiver
D0C37_RS25540	COG5002	protein histidine kinase activity
D0C37_RS25555	COG0705	Rhomboid family
D0C37_RS25590	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS25610	COG0003	Pfam Anion-transporting ATPase
D0C37_RS25620	COG1940	carbohydrate kinase activity
D0C37_RS25675	COG4585	Histidine kinase
D0C37_RS25680	COG2197	response regulator
D0C37_RS25685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0C37_RS25700	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D0C37_RS25705	COG0243	molybdopterin cofactor binding
D0C37_RS25710	COG2193	ferroxidase activity
D0C37_RS25715	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0C37_RS25720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D0C37_RS25725	COG2815	serine threonine protein kinase
D0C37_RS25725	COG0515	serine threonine protein kinase
D0C37_RS25730	COG2022	thiamine diphosphate biosynthetic process
D0C37_RS25740	COG2022	thiamine diphosphate biosynthetic process
D0C37_RS25740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0C37_RS25755	COG0352	thiamine-phosphate diphosphorylase activity
D0C37_RS25775	COG1309	transcriptional regulator
D0C37_RS25785	COG1129	ABC transporter
D0C37_RS25790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0C37_RS25810	COG0714	Associated with various cellular activities
D0C37_RS25820	COG0275	rRNA processing
D0C37_RS25835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0C37_RS25845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0C37_RS25850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0C37_RS25860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0C37_RS25865	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0C37_RS25875	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0C37_RS25895	COG1799	cell septum assembly
D0C37_RS25905	COG3599	regulation of cell shape
D0C37_RS25910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0C37_RS25920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0C37_RS25930	COG2153	protein acetylation
D0C37_RS25945	COG0515	serine threonine protein kinase
D0C37_RS25965	COG0587	DNA-directed DNA polymerase activity
D0C37_RS25970	COG1432	Conserved Protein
D0C37_RS25990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0C37_RS26010	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0C37_RS26015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0C37_RS26020	COG0131	Imidazoleglycerol-phosphate dehydratase
D0C37_RS26025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0C37_RS26030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0C37_RS26035	COG0251	oxidation-reduction process
D0C37_RS26040	COG0107	imidazoleglycerol-phosphate synthase activity
D0C37_RS26050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0C37_RS26060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0C37_RS26090	COG0134	indole-3-glycerol-phosphate synthase activity
D0C37_RS26095	COG0133	tryptophan synthase activity
D0C37_RS26100	COG0159	tryptophan synthase activity
D0C37_RS26110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0C37_RS26120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0C37_RS26155	COG0069	glutamate synthase activity
D0C37_RS26155	COG0070	glutamate synthase
D0C37_RS26155	COG0067	glutamate synthase
D0C37_RS26170	COG1278	Cold shock
D0C37_RS26175	COG0513	Belongs to the DEAD box helicase family
D0C37_RS26185	COG0287	Prephenate dehydrogenase
D0C37_RS26185	COG1605	Chorismate mutase
D0C37_RS26215	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D0C37_RS26220	COG0737	Belongs to the 5'-nucleotidase family
D0C37_RS26260	COG0559	Belongs to the binding-protein-dependent transport system permease family
D0C37_RS26270	COG2746	aminoglycoside 3-N-acetyltransferase activity
D0C37_RS26275	COG2050	protein possibly involved in aromatic compounds catabolism
D0C37_RS26300	COG1643	Atp-dependent helicase
D0C37_RS26305	COG2226	methyltransferase
D0C37_RS26325	COG0237	dephospho-CoA kinase activity
D0C37_RS26350	COG1288	antiporter activity
D0C37_RS26400	COG0477	Major facilitator Superfamily
D0C37_RS26410	COG0584	glycerophosphoryl diester phosphodiesterase
D0C37_RS26420	COG0556	nucleotide-excision repair
D0C37_RS26440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0C37_RS26550	COG2226	methyltransferase
D0C37_RS26575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0C37_RS26590	COG0322	excinuclease ABC activity
D0C37_RS26595	COG1660	Displays ATPase and GTPase activities
D0C37_RS26605	COG1481	regulation of sporulation
D0C37_RS26610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0C37_RS26615	COG0126	phosphoglycerate kinase activity
D0C37_RS26620	COG0149	triose-phosphate isomerase activity
D0C37_RS26625	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0C37_RS26635	COG0166	Belongs to the GPI family
D0C37_RS26640	COG0363	glucosamine-6-phosphate deaminase activity
D0C37_RS26655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0C37_RS26660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0C37_RS26665	COG0109	protoheme IX farnesyltransferase activity
D0C37_RS26680	COG2826	transposase and inactivated derivatives, IS30 family
D0C37_RS26695	COG1131	(ABC) transporter
D0C37_RS26710	COG0719	Fe-S assembly protein
D0C37_RS26720	COG0396	ATPase activity
D0C37_RS26725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0C37_RS26730	COG0822	iron-sulfur transferase activity
D0C37_RS26740	COG2171	N-acyltransferase activity
D0C37_RS26800	COG1902	pentaerythritol trinitrate reductase activity
D0C37_RS26805	COG5285	phytanoyl-CoA dioxygenase
D0C37_RS26810	COG1917	Cupin 2, conserved barrel domain protein
D0C37_RS26820	COG0456	acetyltransferase
D0C37_RS26825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0C37_RS26855	COG1797	cobyrinic acid a,c-diamide synthase activity
D0C37_RS26870	COG1492	cobalamin metabolic process
D0C37_RS26875	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D0C37_RS26890	COG0235	Class ii aldolase
D0C37_RS26910	COG0488	(ABC) transporter
D0C37_RS26920	COG1024	Enoyl-CoA hydratase
D0C37_RS26960	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS26970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0C37_RS26990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D0C37_RS27005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0C37_RS27010	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0C37_RS27020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
D0C37_RS27040	COG2261	transglycosylase associated protein
D0C37_RS27045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0C37_RS27055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0C37_RS27065	COG2186	Transcriptional regulator
D0C37_RS27070	COG2807	transmembrane transport
D0C37_RS27085	COG0560	Phosphoserine phosphatase
D0C37_RS27085	COG3830	Belongs to the UPF0237 family
D0C37_RS27090	COG0842	Transport permease protein
D0C37_RS27090	COG1131	(ABC) transporter
D0C37_RS27090	COG1716	ATPase activity
D0C37_RS27105	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS27115	COG2197	response regulator
D0C37_RS27130	COG1119	ATPase activity
D0C37_RS27150	COG1881	PFAM PEBP family protein
D0C37_RS27160	COG2094	Belongs to the DNA glycosylase MPG family
D0C37_RS27195	COG0647	UMP catabolic process
D0C37_RS27215	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0C37_RS27220	COG0497	DNA recombination
D0C37_RS27235	COG0297	glycogen (starch) synthase activity
D0C37_RS27240	COG3896	Chloramphenicol phosphotransferase-like protein
D0C37_RS27255	COG3387	PFAM Glycoside hydrolase 15-related
D0C37_RS27260	COG0504	CTP synthase activity
D0C37_RS27265	COG0494	nUDIX hydrolase
D0C37_RS27275	COG0686	Belongs to the AlaDH PNT family
D0C37_RS27290	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0C37_RS27295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0C37_RS27300	COG1187	pseudouridine synthase activity
D0C37_RS27310	COG1397	ADP-ribosylglycohydrolase
D0C37_RS27315	COG3541	Predicted nucleotidyltransferase
D0C37_RS27330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0C37_RS27340	COG1160	GTP binding
D0C37_RS27375	COG0671	phosphoesterase, PA-phosphatase related
D0C37_RS27385	COG0477	Major facilitator Superfamily
D0C37_RS27390	COG1799	cell septum assembly
D0C37_RS27415	COG0330	HflC and HflK could
D0C37_RS27430	COG0587	DNA-directed DNA polymerase activity
D0C37_RS27500	COG1216	Glycosyl transferase, family 2
D0C37_RS27520	COG2755	lipolytic protein G-D-S-L family
D0C37_RS27540	COG3973	AAA domain
D0C37_RS27545	COG2188	Transcriptional regulator
D0C37_RS27550	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D0C37_RS27570	COG1309	transcriptional regulator
D0C37_RS27615	COG2826	transposase and inactivated derivatives, IS30 family
D0C37_RS27620	COG3876	Protein conserved in bacteria
D0C37_RS27630	COG0488	(ABC) transporter
D0C37_RS27635	COG0110	maltose O-acetyltransferase activity
D0C37_RS27645	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS27655	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS27675	COG2149	membrane
D0C37_RS27680	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D0C37_RS27695	COG3573	Dehydrogenase
D0C37_RS27720	COG3265	gluconokinase activity
D0C37_RS27730	COG3012	SEC-C Motif Domain Protein
D0C37_RS27735	COG3189	MarR family transcriptional regulator
D0C37_RS27745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0C37_RS27775	COG0667	Aldo Keto reductase
D0C37_RS27780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS27790	COG0598	Magnesium transport protein CorA
D0C37_RS27810	COG0215	cysteine-tRNA ligase activity
D0C37_RS27825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0C37_RS27830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0C37_RS27835	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0C37_RS27845	COG1410	methionine synthase
D0C37_RS27845	COG0646	methionine synthase
D0C37_RS27855	COG0747	negative chemotaxis
D0C37_RS27860	COG2197	response regulator
D0C37_RS27870	COG0517	IMP dehydrogenase activity
D0C37_RS27870	COG1994	Peptidase M50
D0C37_RS27895	COG1222	aaa ATPase
D0C37_RS27900	COG4122	O-methyltransferase activity
D0C37_RS27910	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D0C37_RS27915	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D0C37_RS27930	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D0C37_RS27965	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0C37_RS27970	COG0805	protein transport
D0C37_RS27985	COG2124	cytochrome p450
D0C37_RS28015	COG0564	pseudouridine synthase activity
D0C37_RS28035	COG1595	DNA-templated transcription, initiation
D0C37_RS28045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0C37_RS28050	COG0517	IMP dehydrogenase activity
D0C37_RS28050	COG4175	Glycine betaine
D0C37_RS28075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D0C37_RS28080	COG0531	amino acid
D0C37_RS28085	COG2186	Transcriptional regulator
D0C37_RS28090	COG0174	glutamine synthetase
D0C37_RS28095	COG1012	belongs to the aldehyde dehydrogenase family
D0C37_RS28130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0C37_RS28140	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0C37_RS28145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0C37_RS28150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D0C37_RS28155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0C37_RS28165	COG5002	protein histidine kinase activity
D0C37_RS28170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0C37_RS28175	COG0072	phenylalanine-tRNA ligase activity
D0C37_RS28175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0C37_RS28210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS28230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0C37_RS28230	COG0426	domain, Protein
D0C37_RS28260	COG0667	Aldo Keto reductase
D0C37_RS28270	COG0697	spore germination
D0C37_RS28275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0C37_RS28305	COG2838	Isocitrate dehydrogenase
D0C37_RS28310	COG2826	transposase and inactivated derivatives, IS30 family
D0C37_RS28325	COG1309	transcriptional regulator
D0C37_RS28340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0C37_RS28380	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0C37_RS28385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D0C37_RS28390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D0C37_RS28395	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0C37_RS28400	COG1438	arginine binding
D0C37_RS28405	COG0385	Bile acid
D0C37_RS28415	COG0165	Argininosuccinate lyase
D0C37_RS28435	COG0477	Major facilitator Superfamily
D0C37_RS28440	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS28440	COG0204	Acyl-transferase
D0C37_RS28445	COG0584	glycerophosphoryl diester phosphodiesterase
D0C37_RS28470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0C37_RS28475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0C37_RS28480	COG2011	ABC-type metal ion transport system permease component
D0C37_RS28485	COG1464	Belongs to the NlpA lipoprotein family
D0C37_RS28505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D0C37_RS28510	COG1648	precorrin-2 dehydrogenase activity
D0C37_RS28510	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0C37_RS28600	COG0456	acetyltransferase
D0C37_RS28655	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0C37_RS28660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0C37_RS28675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0C37_RS28680	COG1560	Kdo2-lipid A biosynthetic process
D0C37_RS28685	COG0438	transferase activity, transferring glycosyl groups
D0C37_RS28695	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D0C37_RS28700	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D0C37_RS28705	COG0217	transcriptional regulatory protein
D0C37_RS28710	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D0C37_RS28715	COG0632	four-way junction helicase activity
D0C37_RS28720	COG2255	four-way junction helicase activity
D0C37_RS28730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0C37_RS28735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0C37_RS28740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0C37_RS28745	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0C37_RS28755	COG1196	nuclear chromosome segregation
D0C37_RS28760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0C37_RS28770	COG0124	histidyl-tRNA synthetase
D0C37_RS28785	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D0C37_RS28800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0C37_RS28805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0C37_RS28810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0C37_RS28815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0C37_RS28820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0C37_RS28825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0C37_RS28830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0C37_RS28840	COG0006	proline dipeptidase activity
D0C37_RS28845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0C37_RS28850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0C37_RS28860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D0C37_RS28865	COG0540	Belongs to the ATCase OTCase family
D0C37_RS28870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0C37_RS28880	COG0505	Belongs to the CarA family
D0C37_RS28885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0C37_RS28890	COG0167	dihydroorotate dehydrogenase activity
D0C37_RS28895	COG0284	orotidine-5'-phosphate decarboxylase activity
D0C37_RS28910	COG1758	RNA polymerase activity
D0C37_RS28920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0C37_RS28935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0C37_RS28950	COG2318	DinB family
D0C37_RS28955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0C37_RS28960	COG2390	Transcriptional regulator
D0C37_RS29000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0C37_RS29020	COG0697	spore germination
D0C37_RS29025	COG2233	PERMEase
D0C37_RS29035	COG0738	Major facilitator superfamily
D0C37_RS29040	COG1940	carbohydrate kinase activity
D0C37_RS29040	COG1846	Transcriptional regulator
D0C37_RS29045	COG1090	epimerase
D0C37_RS29060	COG3201	nicotinamide mononucleotide transporter
D0C37_RS29065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0C37_RS29065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0C37_RS29070	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0C37_RS29075	COG0140	phosphoribosyl-ATP diphosphatase activity
D0C37_RS29080	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0C37_RS29110	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS29135	COG0463	Glycosyl transferase, family 2
D0C37_RS29140	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0C37_RS29150	COG2270	Major facilitator Superfamily
D0C37_RS29160	COG2364	Membrane
D0C37_RS29165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0C37_RS29265	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D0C37_RS29285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0C37_RS29295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0C37_RS29330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D0C37_RS29350	COG1716	ATPase activity
D0C37_RS29370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0C37_RS29380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0C37_RS29380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0C37_RS29430	COG1185	polyribonucleotide nucleotidyltransferase activity
D0C37_RS29460	COG0697	spore germination
D0C37_RS29475	COG0697	spore germination
D0C37_RS29495	COG0154	amidase activity
D0C37_RS29535	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0C37_RS29565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D0C37_RS29585	COG1982	Orn Lys Arg decarboxylase major
D0C37_RS29595	COG1968	undecaprenyl-diphosphatase activity
D0C37_RS29670	COG0110	maltose O-acetyltransferase activity
D0C37_RS29680	COG1832	CoA-binding protein
D0C37_RS29685	COG1739	Uncharacterized protein family UPF0029
D0C37_RS29715	COG0420	3'-5' exonuclease activity
D0C37_RS29720	COG0419	ATPase involved in DNA repair
D0C37_RS29725	COG1522	sequence-specific DNA binding
D0C37_RS29735	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS29750	COG0626	cystathionine gamma-synthase activity
D0C37_RS29780	COG1940	carbohydrate kinase activity
D0C37_RS29800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0C37_RS29840	COG0488	(ABC) transporter
D0C37_RS29845	COG0488	(ABC) transporter
D0C37_RS29855	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D0C37_RS29860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0C37_RS29865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0C37_RS29890	COG0791	NLP P60 protein
D0C37_RS29895	COG0740	serine-type endopeptidase activity
D0C37_RS29905	COG0831	urea catabolic process
D0C37_RS29910	COG0832	Belongs to the urease beta subunit family
D0C37_RS29915	COG0804	urea catabolic process
D0C37_RS29925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D0C37_RS29930	COG0829	nickel cation binding
D0C37_RS29935	COG4552	Acetyltransferase involved in intracellular survival and related
D0C37_RS29940	COG0204	Acyl-transferase
D0C37_RS29970	COG1132	(ABC) transporter
D0C37_RS29985	COG2175	clavaminate synthase activity
D0C37_RS29995	COG0435	Glutathione S-transferase
D0C37_RS30000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D0C37_RS30000	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0C37_RS30015	COG0205	6-phosphofructokinase activity
D0C37_RS30020	COG3442	glutamine amidotransferase
D0C37_RS30030	COG0242	peptide deformylase activity
D0C37_RS30040	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS30060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0C37_RS30085	COG1175	transmembrane transport
D0C37_RS30090	COG0395	ABC-type sugar transport system, permease component
D0C37_RS30095	COG2723	6-phospho-beta-galactosidase activity
D0C37_RS30100	COG0501	Belongs to the peptidase M48B family
D0C37_RS30170	COG4251	negative regulation of phosphorylation
D0C37_RS30175	COG0784	Response regulator, receiver
D0C37_RS30195	COG0656	L-ascorbic acid biosynthetic process
D0C37_RS30205	COG1595	DNA-templated transcription, initiation
D0C37_RS30215	COG1132	(ABC) transporter
D0C37_RS30240	COG3693	PFAM glycoside hydrolase, family 10
D0C37_RS30245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0C37_RS30275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0C37_RS30280	COG3279	Response regulator of the LytR AlgR family
D0C37_RS30290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0C37_RS30295	COG3275	phosphorelay sensor kinase activity
D0C37_RS30360	COG0583	DNA-binding transcription factor activity
D0C37_RS30370	COG1053	succinate dehydrogenase
D0C37_RS30375	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0C37_RS30380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0C37_RS30385	COG1695	Transcriptional regulator
D0C37_RS30400	COG1131	(ABC) transporter
D0C37_RS30415	COG3360	Dodecin
D0C37_RS30420	COG2182	Extracellular solute-binding protein
D0C37_RS30425	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D0C37_RS30430	COG0121	glutamine amidotransferase
D0C37_RS30435	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D0C37_RS30455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0C37_RS30460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0C37_RS30510	COG2175	clavaminate synthase activity
D0C37_RS30545	COG2197	response regulator
D0C37_RS30570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS30585	COG1959	2 iron, 2 sulfur cluster binding
D0C37_RS30590	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS30615	COG2837	iron assimilation
D0C37_RS30625	COG1796	DNA polymerase
D0C37_RS30625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0C37_RS30630	COG0142	geranyltranstransferase activity
D0C37_RS30665	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D0C37_RS30690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0C37_RS30700	COG0254	rRNA binding
D0C37_RS30705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0C37_RS30710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0C37_RS30715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0C37_RS30745	COG0477	Major facilitator Superfamily
D0C37_RS30770	COG3119	arylsulfatase activity
D0C37_RS30790	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0C37_RS30795	COG4948	Mandelate Racemase Muconate Lactonizing
D0C37_RS30900	COG3655	Transcriptional regulator
D0C37_RS30910	COG4257	antibiotic catabolic process
D0C37_RS30930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0C37_RS30935	COG1121	(ABC) transporter
D0C37_RS30940	COG4335	DNA alkylation repair
D0C37_RS30945	COG4608	Belongs to the ABC transporter superfamily
D0C37_RS30950	COG0444	Belongs to the ABC transporter superfamily
D0C37_RS30960	COG0747	negative chemotaxis
D0C37_RS30970	COG3458	cephalosporin-C deacetylase activity
D0C37_RS30980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0C37_RS30990	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D0C37_RS30995	COG0363	glucosamine-6-phosphate deaminase activity
D0C37_RS31000	COG0590	tRNA wobble adenosine to inosine editing
D0C37_RS31005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0C37_RS31040	COG0300	oxidoreductase activity
D0C37_RS31050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0C37_RS31085	COG0745	RESPONSE REGULATOR receiver
D0C37_RS31090	COG0243	molybdopterin cofactor binding
D0C37_RS31095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0C37_RS31100	COG2146	nitrite reductase [NAD(P)H] activity
D0C37_RS31100	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0C37_RS31135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D0C37_RS31140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0C37_RS31145	COG1984	allophanate hydrolase subunit 2
D0C37_RS31160	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0C37_RS31170	COG0110	maltose O-acetyltransferase activity
D0C37_RS31200	COG0242	peptide deformylase activity
D0C37_RS31205	COG0494	nUDIX hydrolase
D0C37_RS31215	COG1414	Transcriptional regulator
D0C37_RS31220	COG1414	Transcriptional regulator
D0C37_RS31225	COG3971	2-oxopent-4-enoate hydratase activity
D0C37_RS31240	COG2267	carboxylic ester hydrolase activity
D0C37_RS31295	COG2124	cytochrome p450
D0C37_RS31300	COG1174	glycine betaine transport
D0C37_RS31305	COG1174	glycine betaine transport
D0C37_RS31315	COG0517	IMP dehydrogenase activity
D0C37_RS31315	COG1125	glycine betaine transport
D0C37_RS31340	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS31345	COG1960	acyl-CoA dehydrogenase activity
D0C37_RS31355	COG0601	transmembrane transport
D0C37_RS31360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0C37_RS31365	COG0444	Belongs to the ABC transporter superfamily
D0C37_RS31370	COG4608	Belongs to the ABC transporter superfamily
D0C37_RS31390	COG2318	DinB family
D0C37_RS31415	COG0277	FAD linked oxidase domain protein
D0C37_RS31420	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0C37_RS31430	COG2814	Major facilitator Superfamily
D0C37_RS31480	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS31490	COG0142	geranyltranstransferase activity
D0C37_RS31530	COG0604	alcohol dehydrogenase
D0C37_RS31530	COG3321	synthase
D0C37_RS31545	COG0604	alcohol dehydrogenase
D0C37_RS31545	COG3321	synthase
D0C37_RS31560	COG0604	alcohol dehydrogenase
D0C37_RS31560	COG3321	synthase
D0C37_RS31585	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0C37_RS31620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0C37_RS31630	COG1129	ABC transporter
D0C37_RS31660	COG3483	tryptophan 2,3-dioxygenase activity
D0C37_RS31665	COG1028	Short-chain dehydrogenase reductase Sdr
D0C37_RS31670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0C37_RS31675	COG2151	metal-sulfur cluster biosynthetic enzyme
D0C37_RS31680	COG3396	Phenylacetate-CoA oxygenase
D0C37_RS31690	COG3396	Phenylacetate-CoA oxygenase
D0C37_RS31700	COG0318	PFAM AMP-dependent synthetase and ligase
D0C37_RS31705	COG0604	alcohol dehydrogenase
D0C37_RS31715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0C37_RS31740	COG3246	L-lysine catabolic process to acetate
D0C37_RS31745	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0C37_RS31800	COG1686	Belongs to the peptidase S11 family
D0C37_RS31805	COG2367	Beta-lactamase
D0C37_RS31875	COG4249	Peptidase C14 caspase catalytic subunit p20
D0C37_RS31875	COG2319	Wd-40 repeat
D0C37_RS31895	COG2801	Transposase and inactivated derivatives