locus-tag	class	description
SLLC_RS00030	COG0346	lactoylglutathione lyase activity
SLLC_RS00035	COG1595	DNA-templated transcription, initiation
SLLC_RS00050	COG1309	transcriptional regulator
SLLC_RS00095	COG1940	carbohydrate kinase activity
SLLC_RS00100	COG0531	amino acid
SLLC_RS00120	COG0656	L-ascorbic acid biosynthetic process
SLLC_RS00150	COG3903	Transcriptional regulator
SLLC_RS00150	COG3629	intracellular signal transduction
SLLC_RS00295	COG1522	sequence-specific DNA binding
SLLC_RS00360	COG0583	DNA-binding transcription factor activity
SLLC_RS00400	COG1228	amidohydrolase
SLLC_RS00410	COG2267	carboxylic ester hydrolase activity
SLLC_RS00415	COG2259	Doxx family
SLLC_RS00420	COG1335	isochorismatase
SLLC_RS00430	COG4221	oxidoreductase activity
SLLC_RS00455	COG2378	regulation of single-species biofilm formation
SLLC_RS00480	COG3415	Transposase
SLLC_RS00480	COG2801	Transposase and inactivated derivatives
SLLC_RS00495	COG0277	FAD linked oxidase domain protein
SLLC_RS00515	COG0395	ABC-type sugar transport system, permease component
SLLC_RS00520	COG1175	transmembrane transport
SLLC_RS00525	COG2182	Extracellular solute-binding protein
SLLC_RS00545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SLLC_RS00555	COG1609	Transcriptional regulator
SLLC_RS00565	COG0395	ABC-type sugar transport system, permease component
SLLC_RS00575	COG1653	transport
SLLC_RS00605	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS00625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS00645	COG1595	DNA-templated transcription, initiation
SLLC_RS00695	COG1846	Transcriptional regulator
SLLC_RS00705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLLC_RS00715	COG1737	Transcriptional regulator
SLLC_RS00765	COG3321	synthase
SLLC_RS00765	COG0604	alcohol dehydrogenase
SLLC_RS00850	COG2045	Belongs to the ComB family
SLLC_RS00865	COG1309	transcriptional regulator
SLLC_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS00880	COG0662	Cupin 2, conserved barrel domain protein
SLLC_RS00900	COG4175	Glycine betaine
SLLC_RS00900	COG0517	IMP dehydrogenase activity
SLLC_RS00910	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS00915	COG1309	transcriptional regulator
SLLC_RS00920	COG0300	oxidoreductase activity
SLLC_RS00925	COG0640	Transcriptional regulator
SLLC_RS00930	COG0477	Major facilitator Superfamily
SLLC_RS00945	COG1309	transcriptional regulator
SLLC_RS00975	COG1902	pentaerythritol trinitrate reductase activity
SLLC_RS00990	COG4941	Belongs to the sigma-70 factor family
SLLC_RS00995	COG3795	YCII-related domain
SLLC_RS01030	COG1660	Displays ATPase and GTPase activities
SLLC_RS01055	COG2124	cytochrome p450
SLLC_RS01060	COG2259	Doxx family
SLLC_RS01110	COG0657	acetylesterase activity
SLLC_RS01120	COG1609	Transcriptional regulator
SLLC_RS01135	COG3250	beta-galactosidase activity
SLLC_RS01160	COG2340	Cysteine-rich secretory protein family
SLLC_RS01175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLLC_RS01185	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SLLC_RS01195	COG0667	Aldo Keto reductase
SLLC_RS01250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SLLC_RS01290	COG0583	DNA-binding transcription factor activity
SLLC_RS01370	COG0395	ABC-type sugar transport system, permease component
SLLC_RS01415	COG0328	RNA-DNA hybrid ribonuclease activity
SLLC_RS01425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SLLC_RS01430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLLC_RS01445	COG0668	transmembrane transport
SLLC_RS01475	COG1309	transcriptional regulator
SLLC_RS01510	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SLLC_RS01530	COG0477	Major facilitator Superfamily
SLLC_RS01560	COG4044	May play a role in the intracellular transport of hydrophobic ligands
SLLC_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS01575	COG1309	transcriptional regulator
SLLC_RS01600	COG1228	amidohydrolase
SLLC_RS01605	COG2132	Multicopper oxidase
SLLC_RS01615	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
SLLC_RS01620	COG0477	Major facilitator Superfamily
SLLC_RS01625	COG1376	ErfK ybiS ycfS ynhG family protein
SLLC_RS01630	COG0009	L-threonylcarbamoyladenylate synthase
SLLC_RS01635	COG3629	intracellular signal transduction
SLLC_RS01635	COG3903	Transcriptional regulator
SLLC_RS01705	COG0583	DNA-binding transcription factor activity
SLLC_RS01710	COG0789	Transcriptional regulator
SLLC_RS01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS01745	COG0747	negative chemotaxis
SLLC_RS01755	COG1309	transcriptional regulator
SLLC_RS01765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS01795	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS01800	COG3979	chitinase
SLLC_RS01805	COG2304	oxidoreductase activity
SLLC_RS01810	COG1278	Cold shock
SLLC_RS01815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLLC_RS01830	COG0789	Transcriptional regulator
SLLC_RS01850	COG4249	Peptidase C14 caspase catalytic subunit p20
SLLC_RS01850	COG2319	Wd-40 repeat
SLLC_RS01895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SLLC_RS01895	COG1796	DNA polymerase
SLLC_RS01925	COG2272	Belongs to the type-B carboxylesterase lipase family
SLLC_RS01990	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SLLC_RS02005	COG2197	response regulator
SLLC_RS02010	COG4585	Histidine kinase
SLLC_RS02015	COG2409	Drug exporters of the RND superfamily
SLLC_RS02025	COG4175	Glycine betaine
SLLC_RS02025	COG3448	diguanylate cyclase activity
SLLC_RS02030	COG1191	sigma factor activity
SLLC_RS02040	COG2188	Transcriptional regulator
SLLC_RS02050	COG4264	IucA IucC family
SLLC_RS02055	COG2226	methyltransferase
SLLC_RS02075	COG4585	Histidine kinase
SLLC_RS02080	COG2197	response regulator
SLLC_RS02110	COG1132	(ABC) transporter
SLLC_RS02120	COG0592	DNA-directed DNA polymerase activity
SLLC_RS02140	COG3265	gluconokinase activity
SLLC_RS02170	COG1404	Belongs to the peptidase S8 family
SLLC_RS02170	COG1404	Belongs to the peptidase S8 family
SLLC_RS02170	COG4412	M6 family metalloprotease domain protein
SLLC_RS02170	COG4412	M6 family metalloprotease domain protein
SLLC_RS02175	COG0477	Major facilitator Superfamily
SLLC_RS02195	COG1793	dna ligase
SLLC_RS02200	COG1131	(ABC) transporter
SLLC_RS02215	COG0667	Aldo Keto reductase
SLLC_RS02220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLLC_RS02230	COG1609	Transcriptional regulator
SLLC_RS02235	COG0673	inositol 2-dehydrogenase activity
SLLC_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS02280	COG1120	ATPase activity
SLLC_RS02285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLLC_RS02340	COG1414	Transcriptional regulator
SLLC_RS02355	COG0076	glutamate decarboxylase activity
SLLC_RS02370	COG4565	transcriptional regulatory protein
SLLC_RS02380	COG1301	dicarboxylic acid transport
SLLC_RS02405	COG0596	Alpha beta hydrolase
SLLC_RS02425	COG3511	phospholipase C
SLLC_RS02430	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
SLLC_RS02450	COG2304	oxidoreductase activity
SLLC_RS02475	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS02480	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS02505	COG1024	Enoyl-CoA hydratase
SLLC_RS02530	COG0583	DNA-binding transcription factor activity
SLLC_RS02535	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLLC_RS02545	COG2197	response regulator
SLLC_RS02550	COG4585	Histidine kinase
SLLC_RS02560	COG1131	(ABC) transporter
SLLC_RS02570	COG0515	serine threonine protein kinase
SLLC_RS02570	COG2815	serine threonine protein kinase
SLLC_RS02615	COG3864	Putative metallopeptidase domain
SLLC_RS02645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS02660	COG0693	protein deglycase activity
SLLC_RS02665	COG2356	endonuclease I
SLLC_RS02680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SLLC_RS02685	COG3583	domain protein
SLLC_RS02685	COG3064	Membrane
SLLC_RS02685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SLLC_RS02695	COG2814	Major facilitator Superfamily
SLLC_RS02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SLLC_RS02740	COG4106	trans-aconitate 2-methyltransferase activity
SLLC_RS02745	COG0393	Putative heavy-metal-binding
SLLC_RS02815	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS02830	COG1476	TRANSCRIPTIONal
SLLC_RS02850	COG0745	RESPONSE REGULATOR receiver
SLLC_RS02865	COG1132	(ABC) transporter
SLLC_RS02880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLLC_RS02910	COG0515	serine threonine protein kinase
SLLC_RS02910	COG2815	serine threonine protein kinase
SLLC_RS02925	COG0714	Associated with various cellular activities
SLLC_RS02940	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SLLC_RS03005	COG1349	DNA-binding transcription factor activity
SLLC_RS03010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SLLC_RS03060	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLLC_RS03080	COG0702	epimerase
SLLC_RS03105	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS03120	COG2326	polyphosphate kinase activity
SLLC_RS03180	COG0148	phosphopyruvate hydratase activity
SLLC_RS03190	COG3415	Transposase
SLLC_RS03190	COG2801	Transposase and inactivated derivatives
SLLC_RS03215	COG2271	Major facilitator Superfamily
SLLC_RS03250	COG1819	glycosyl
SLLC_RS03320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SLLC_RS03330	COG2815	serine threonine protein kinase
SLLC_RS03330	COG0515	serine threonine protein kinase
SLLC_RS03340	COG0586	Pfam SNARE associated Golgi protein
SLLC_RS03345	COG0671	phosphoesterase, PA-phosphatase related
SLLC_RS03375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLLC_RS03380	COG0019	diaminopimelate decarboxylase activity
SLLC_RS03395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SLLC_RS03400	COG0531	amino acid
SLLC_RS03415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SLLC_RS03420	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SLLC_RS03425	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
SLLC_RS03510	COG1289	transmembrane transporter activity
SLLC_RS03535	COG0542	response to heat
SLLC_RS03545	COG0484	heat shock protein binding
SLLC_RS03550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SLLC_RS03555	COG0443	Heat shock 70 kDa protein
SLLC_RS03600	COG0494	nUDIX hydrolase
SLLC_RS03795	COG1205	dead DEAH box helicase
SLLC_RS03795	COG1111	helicase
SLLC_RS03810	COG0515	serine threonine protein kinase
SLLC_RS03810	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SLLC_RS03845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLLC_RS03860	COG0017	Asparaginyl-tRNA synthetase
SLLC_RS03890	COG2813	Specifically methylates the guanine in position
SLLC_RS03915	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SLLC_RS03940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLLC_RS03950	COG0183	Belongs to the thiolase family
SLLC_RS03955	COG1609	Transcriptional regulator
SLLC_RS03965	COG0596	Alpha beta hydrolase
SLLC_RS04010	COG3572	ergothioneine biosynthetic process
SLLC_RS04015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SLLC_RS04020	COG0121	glutamine amidotransferase
SLLC_RS04025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
SLLC_RS04040	COG2182	Extracellular solute-binding protein
SLLC_RS04045	COG3360	Dodecin
SLLC_RS04055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS04070	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SLLC_RS04075	COG1053	succinate dehydrogenase
SLLC_RS04085	COG0583	DNA-binding transcription factor activity
SLLC_RS04095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS04130	COG0726	polysaccharide deacetylase
SLLC_RS04135	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SLLC_RS04135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SLLC_RS04180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLLC_RS04200	COG4762	Protein conserved in bacteria
SLLC_RS04250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SLLC_RS04305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SLLC_RS04375	COG0517	IMP dehydrogenase activity
SLLC_RS04375	COG0516	GMP reductase activity
SLLC_RS04405	COG2770	Histidine kinase
SLLC_RS04405	COG2208	phosphoserine phosphatase activity
SLLC_RS04455	COG1278	Cold shock
SLLC_RS04460	COG0513	Belongs to the DEAD box helicase family
SLLC_RS04505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SLLC_RS04575	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLLC_RS04575	COG1902	pentaerythritol trinitrate reductase activity
SLLC_RS04600	COG0395	ABC-type sugar transport system, permease component
SLLC_RS04605	COG1175	transmembrane transport
SLLC_RS04630	COG0277	FAD linked oxidase domain protein
SLLC_RS04660	COG0589	response to stress
SLLC_RS04675	COG3345	alpha-galactosidase
SLLC_RS04715	COG1024	Enoyl-CoA hydratase
SLLC_RS04730	COG1335	isochorismatase
SLLC_RS04740	COG1366	Belongs to the anti-sigma-factor antagonist family
SLLC_RS04755	COG0154	amidase activity
SLLC_RS04805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SLLC_RS04805	COG0617	tRNA 3'-terminal CCA addition
SLLC_RS04805	COG0517	IMP dehydrogenase activity
SLLC_RS04840	COG0517	IMP dehydrogenase activity
SLLC_RS04840	COG0516	GMP reductase activity
SLLC_RS04850	COG0517	IMP dehydrogenase activity
SLLC_RS04850	COG0516	GMP reductase activity
SLLC_RS04870	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
SLLC_RS04885	COG0589	response to stress
SLLC_RS04900	COG1063	alcohol dehydrogenase
SLLC_RS04910	COG0516	GMP reductase activity
SLLC_RS04910	COG0517	IMP dehydrogenase activity
SLLC_RS04925	COG0346	lactoylglutathione lyase activity
SLLC_RS04930	COG1556	Lactate utilization protein
SLLC_RS04935	COG1139	Iron-sulfur cluster binding protein
SLLC_RS04940	COG0247	lactate metabolic process
SLLC_RS04950	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SLLC_RS04975	COG3119	arylsulfatase activity
SLLC_RS04975	COG3119	arylsulfatase activity
SLLC_RS04980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
SLLC_RS04990	COG2838	Isocitrate dehydrogenase
SLLC_RS04995	COG3152	Membrane
SLLC_RS05000	COG5002	protein histidine kinase activity
SLLC_RS05000	COG5000	phosphorelay sensor kinase activity
SLLC_RS05005	COG0745	RESPONSE REGULATOR receiver
SLLC_RS05035	COG1595	DNA-templated transcription, initiation
SLLC_RS05045	COG2226	methyltransferase
SLLC_RS05055	COG0598	Magnesium transport protein CorA
SLLC_RS05060	COG0583	DNA-binding transcription factor activity
SLLC_RS05095	COG1132	(ABC) transporter
SLLC_RS05135	COG2175	clavaminate synthase activity
SLLC_RS05145	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SLLC_RS05165	COG1335	isochorismatase
SLLC_RS05195	COG3959	Transketolase, thiamine diphosphate binding domain
SLLC_RS05200	COG3958	Transketolase
SLLC_RS05235	COG2755	lipolytic protein G-D-S-L family
SLLC_RS05265	COG1657	PFAM Prenyltransferase squalene oxidase
SLLC_RS05275	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SLLC_RS05285	COG1562	ergosterol biosynthetic process
SLLC_RS05290	COG1134	teichoic acid transport
SLLC_RS05310	COG0371	Dehydrogenase
SLLC_RS05330	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SLLC_RS05340	COG1024	Enoyl-CoA hydratase
SLLC_RS05350	COG4977	sequence-specific DNA binding
SLLC_RS05355	COG0488	(ABC) transporter
SLLC_RS05365	COG0300	oxidoreductase activity
SLLC_RS05380	COG2183	response to ionizing radiation
SLLC_RS05430	COG1022	Amp-dependent synthetase and ligase
SLLC_RS05435	COG0789	Transcriptional regulator
SLLC_RS05445	COG1024	Enoyl-CoA hydratase
SLLC_RS05445	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLLC_RS05450	COG0183	Belongs to the thiolase family
SLLC_RS05455	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS05460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS05465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLLC_RS05475	COG3268	Saccharopine dehydrogenase
SLLC_RS05480	COG1515	deoxyribonuclease V activity
SLLC_RS05505	COG0488	(ABC) transporter
SLLC_RS05535	COG1793	dna ligase
SLLC_RS05545	COG0494	nUDIX hydrolase
SLLC_RS05560	COG1486	melibiose metabolic process
SLLC_RS05605	COG2197	response regulator
SLLC_RS05620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLLC_RS05660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLLC_RS05665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SLLC_RS05705	COG0656	L-ascorbic acid biosynthetic process
SLLC_RS05715	COG2154	pterin-4-alpha-carbinolamine dehydratase
SLLC_RS05750	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLLC_RS05760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SLLC_RS05770	COG0531	amino acid
SLLC_RS05830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLLC_RS05850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLLC_RS05855	COG2362	D-Aminopeptidase
SLLC_RS05880	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLLC_RS05890	COG0604	alcohol dehydrogenase
SLLC_RS05895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS05895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS05910	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS05915	COG0688	phosphatidylethanolamine metabolic process
SLLC_RS05930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SLLC_RS05945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SLLC_RS05950	COG1929	Belongs to the glycerate kinase type-1 family
SLLC_RS05955	COG1335	isochorismatase
SLLC_RS05995	COG1448	Aminotransferase
SLLC_RS06010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SLLC_RS06020	COG0483	inositol monophosphate 1-phosphatase activity
SLLC_RS06030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLLC_RS06040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
SLLC_RS06085	COG0604	alcohol dehydrogenase
SLLC_RS06085	COG3321	synthase
SLLC_RS06090	COG3321	synthase
SLLC_RS06090	COG0604	alcohol dehydrogenase
SLLC_RS06125	COG0604	alcohol dehydrogenase
SLLC_RS06125	COG3321	synthase
SLLC_RS06150	COG4585	Histidine kinase
SLLC_RS06155	COG2197	response regulator
SLLC_RS06170	COG0435	Glutathione S-transferase
SLLC_RS06210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLLC_RS06215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SLLC_RS06245	COG0405	Gamma-glutamyltransferase
SLLC_RS06265	COG2205	protein histidine kinase activity
SLLC_RS06270	COG0745	RESPONSE REGULATOR receiver
SLLC_RS06280	COG1376	ErfK ybiS ycfS ynhG family protein
SLLC_RS06290	COG0765	amino acid transport
SLLC_RS06295	COG0765	amino acid transport
SLLC_RS06300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS06305	COG1126	abc transporter atp-binding protein
SLLC_RS06330	COG1940	carbohydrate kinase activity
SLLC_RS06335	COG1129	ABC transporter
SLLC_RS06350	COG0673	inositol 2-dehydrogenase activity
SLLC_RS06365	COG4266	Belongs to the allantoicase family
SLLC_RS06370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLLC_RS06375	COG1414	Transcriptional regulator
SLLC_RS06385	COG1136	(ABC) transporter
SLLC_RS06395	COG4585	Histidine kinase
SLLC_RS06400	COG2197	response regulator
SLLC_RS06425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SLLC_RS06455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS06460	COG2233	PERMEase
SLLC_RS06475	COG2351	hydroxyisourate hydrolase activity
SLLC_RS06495	COG3622	Belongs to the hyi family
SLLC_RS06500	COG2084	Dehydrogenase
SLLC_RS06505	COG0753	catalase activity
SLLC_RS06515	COG3960	tartronate-semialdehyde synthase activity
SLLC_RS06525	COG0386	Belongs to the glutathione peroxidase family
SLLC_RS06545	COG0464	growth
SLLC_RS06585	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS06595	COG0598	Magnesium transport protein CorA
SLLC_RS06635	COG2124	cytochrome p450
SLLC_RS06645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS06690	COG0308	aminopeptidase N
SLLC_RS06695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS06720	COG1937	Protein conserved in bacteria
SLLC_RS06745	COG4555	ABC transporter
SLLC_RS06760	COG0563	adenylate kinase activity
SLLC_RS06775	COG0574	Belongs to the PEP-utilizing enzyme family
SLLC_RS06775	COG3848	Pyruvate phosphate dikinase
SLLC_RS06820	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS06825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLLC_RS06825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLLC_RS06855	COG0646	methionine synthase
SLLC_RS06855	COG1410	methionine synthase
SLLC_RS06860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLLC_RS06865	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SLLC_RS06885	COG4106	trans-aconitate 2-methyltransferase activity
SLLC_RS06910	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLLC_RS06940	COG3903	Transcriptional regulator
SLLC_RS06940	COG3629	intracellular signal transduction
SLLC_RS06955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS06970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS06980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS06980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS06985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS07005	COG0017	Asparaginyl-tRNA synthetase
SLLC_RS07010	COG0069	glutamate synthase activity
SLLC_RS07050	COG2197	response regulator
SLLC_RS07065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS07145	COG4552	Acetyltransferase involved in intracellular survival and related
SLLC_RS07160	COG2252	PERMEase
SLLC_RS07165	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLLC_RS07180	COG3835	regulator
SLLC_RS07190	COG1802	Transcriptional regulator
SLLC_RS07210	COG0028	Belongs to the TPP enzyme family
SLLC_RS07220	COG1404	Belongs to the peptidase S8 family
SLLC_RS07235	COG1162	GTPase activity
SLLC_RS07255	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS07265	COG0456	acetyltransferase
SLLC_RS07265	COG1846	Transcriptional regulator
SLLC_RS07280	COG0175	sulfate reduction
SLLC_RS07285	COG0529	Catalyzes the synthesis of activated sulfate
SLLC_RS07310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SLLC_RS07325	COG0667	Aldo Keto reductase
SLLC_RS07340	COG0604	alcohol dehydrogenase
SLLC_RS07440	COG0583	DNA-binding transcription factor activity
SLLC_RS07445	COG0504	CTP synthase activity
SLLC_RS07470	COG3511	phospholipase C
SLLC_RS07480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLLC_RS07485	COG1216	Glycosyl transferase, family 2
SLLC_RS07490	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS07495	COG0463	Glycosyl transferase, family 2
SLLC_RS07510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLLC_RS07515	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SLLC_RS07555	COG1116	anion transmembrane transporter activity
SLLC_RS07570	COG3220	belongs to the UPF0276 family
SLLC_RS07580	COG0596	Alpha beta hydrolase
SLLC_RS07585	COG3253	May function as heme-dependent peroxidase
SLLC_RS07590	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SLLC_RS07600	COG0446	pyridine nucleotide-disulphide oxidoreductase
SLLC_RS07605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SLLC_RS07630	COG0183	Belongs to the thiolase family
SLLC_RS07635	COG1024	Enoyl-CoA hydratase
SLLC_RS07635	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLLC_RS07645	COG0463	Glycosyl transferase, family 2
SLLC_RS07645	COG1216	Glycosyl transferase, family 2
SLLC_RS07655	COG1083	cytidylyl-transferase
SLLC_RS07660	COG2089	acid synthase
SLLC_RS07675	COG1316	TRANSCRIPTIONal
SLLC_RS07680	COG0531	amino acid
SLLC_RS07685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SLLC_RS07690	COG4214	carbohydrate transport
SLLC_RS07700	COG4213	ABC transporter substrate-binding protein
SLLC_RS07705	COG1940	carbohydrate kinase activity
SLLC_RS07715	COG1285	pathogenesis
SLLC_RS07720	COG0395	ABC-type sugar transport system, permease component
SLLC_RS07725	COG1175	transmembrane transport
SLLC_RS07730	COG1653	transport
SLLC_RS07735	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SLLC_RS07740	COG1609	Transcriptional regulator
SLLC_RS07750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLLC_RS07785	COG4608	Belongs to the ABC transporter superfamily
SLLC_RS07800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS07830	COG3938	Belongs to the proline racemase family
SLLC_RS07860	COG0006	proline dipeptidase activity
SLLC_RS07870	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS07895	COG1024	Enoyl-CoA hydratase
SLLC_RS07905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SLLC_RS07920	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
SLLC_RS07930	COG2040	homocysteine
SLLC_RS07960	COG1799	cell septum assembly
SLLC_RS07980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS07985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SLLC_RS08000	COG0431	NADPH-dependent FMN reductase
SLLC_RS08030	COG0252	asparaginase activity
SLLC_RS08040	COG3629	intracellular signal transduction
SLLC_RS08040	COG3903	Transcriptional regulator
SLLC_RS08050	COG0577	efflux transmembrane transporter activity
SLLC_RS08050	COG1136	(ABC) transporter
SLLC_RS08085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SLLC_RS08105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS08130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLLC_RS08150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SLLC_RS08165	COG0475	glutathione-regulated potassium exporter activity
SLLC_RS08175	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SLLC_RS08180	COG0531	amino acid
SLLC_RS08185	COG0569	domain protein
SLLC_RS08220	COG0756	dUTP diphosphatase activity
SLLC_RS08245	COG2205	protein histidine kinase activity
SLLC_RS08250	COG0745	RESPONSE REGULATOR receiver
SLLC_RS08265	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SLLC_RS08345	COG1309	transcriptional regulator
SLLC_RS08350	COG1435	thymidine kinase activity
SLLC_RS08365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLLC_RS08365	COG0045	succinate-CoA ligase (ADP-forming) activity
SLLC_RS08365	COG1042	CoA-binding domain protein
SLLC_RS08370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLLC_RS08375	COG1802	Transcriptional regulator
SLLC_RS08390	COG0612	Peptidase, M16
SLLC_RS08395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLLC_RS08415	COG0372	Belongs to the citrate synthase family
SLLC_RS08425	COG1672	PFAM Archaeal ATPase
SLLC_RS08425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SLLC_RS08445	COG3290	protein histidine kinase activity
SLLC_RS08450	COG4565	transcriptional regulatory protein
SLLC_RS08455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SLLC_RS08480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SLLC_RS08490	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
SLLC_RS08525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SLLC_RS08545	COG0588	phosphoglycerate mutase activity
SLLC_RS08570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SLLC_RS08575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SLLC_RS08580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SLLC_RS08615	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SLLC_RS08625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SLLC_RS08630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
SLLC_RS08640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SLLC_RS08660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLLC_RS08670	COG0583	DNA-binding transcription factor activity
SLLC_RS08685	COG1609	Transcriptional regulator
SLLC_RS08705	COG2205	protein histidine kinase activity
SLLC_RS08710	COG0745	RESPONSE REGULATOR receiver
SLLC_RS08715	COG1126	abc transporter atp-binding protein
SLLC_RS08720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS08725	COG0765	amino acid transport
SLLC_RS08730	COG0765	amino acid transport
SLLC_RS08735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS08755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SLLC_RS08775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
SLLC_RS08830	COG1201	RNA secondary structure unwinding
SLLC_RS08840	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLLC_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS08850	COG1396	sequence-specific DNA binding
SLLC_RS08855	COG1546	Belongs to the CinA family
SLLC_RS08855	COG1058	Belongs to the CinA family
SLLC_RS08865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SLLC_RS08875	COG1674	ftsk spoiiie
SLLC_RS08885	COG3437	response regulator, receiver
SLLC_RS08885	COG3850	Histidine kinase
SLLC_RS08885	COG4999	Histidine kinase
SLLC_RS08885	COG2205	protein histidine kinase activity
SLLC_RS08890	COG2770	Histidine kinase
SLLC_RS08890	COG2208	phosphoserine phosphatase activity
SLLC_RS08920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SLLC_RS08925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SLLC_RS08930	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SLLC_RS08950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SLLC_RS08955	COG0612	Peptidase, M16
SLLC_RS08960	COG1185	polyribonucleotide nucleotidyltransferase activity
SLLC_RS08965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SLLC_RS08975	COG1674	ftsk spoiiie
SLLC_RS08995	COG1404	Belongs to the peptidase S8 family
SLLC_RS09000	COG3266	domain, Protein
SLLC_RS09015	COG0455	bacterial-type flagellum organization
SLLC_RS09030	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SLLC_RS09035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SLLC_RS09045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SLLC_RS09060	COG0779	Required for maturation of 30S ribosomal subunits
SLLC_RS09085	COG0442	prolyl-tRNA aminoacylation
SLLC_RS09100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SLLC_RS09105	COG0750	zinc metalloprotease
SLLC_RS09110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SLLC_RS09125	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS09130	COG2508	Transcriptional regulator
SLLC_RS09160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SLLC_RS09165	COG1177	transmembrane transport
SLLC_RS09170	COG1176	ABC-type spermidine putrescine transport system, permease component I
SLLC_RS09175	COG3842	ATPase activity
SLLC_RS09180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SLLC_RS09185	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS09195	COG1051	belongs to the nudix hydrolase family
SLLC_RS09205	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SLLC_RS09215	COG4585	Histidine kinase
SLLC_RS09220	COG2197	response regulator
SLLC_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS09245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SLLC_RS09250	COG1136	(ABC) transporter
SLLC_RS09290	COG3842	ATPase activity
SLLC_RS09305	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SLLC_RS09310	COG0575	Belongs to the CDS family
SLLC_RS09315	COG0233	cytoplasmic translational termination
SLLC_RS09320	COG0528	UMP kinase activity
SLLC_RS09325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SLLC_RS09330	COG0052	Belongs to the universal ribosomal protein uS2 family
SLLC_RS09345	COG1191	sigma factor activity
SLLC_RS09360	COG0792	nuclease activity
SLLC_RS09385	COG0681	Belongs to the peptidase S26 family
SLLC_RS09390	COG0681	Belongs to the peptidase S26 family
SLLC_RS09395	COG0335	large ribosomal subunit rRNA binding
SLLC_RS09400	COG0336	Belongs to the RNA methyltransferase TrmD family
SLLC_RS09405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SLLC_RS09410	COG1837	Belongs to the UPF0109 family
SLLC_RS09415	COG0228	four-way junction DNA binding
SLLC_RS09425	COG0442	prolyl-tRNA aminoacylation
SLLC_RS09435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLLC_RS09445	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
SLLC_RS09475	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
SLLC_RS09485	COG0477	Major facilitator Superfamily
SLLC_RS09490	COG1196	nuclear chromosome segregation
SLLC_RS09500	COG1254	Belongs to the acylphosphatase family
SLLC_RS09505	COG2340	Cysteine-rich secretory protein family
SLLC_RS09510	COG0655	NAD(P)H dehydrogenase (quinone) activity
SLLC_RS09515	COG1733	regulation of RNA biosynthetic process
SLLC_RS09520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SLLC_RS09525	COG0571	ribonuclease III activity
SLLC_RS09530	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SLLC_RS09545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SLLC_RS09550	COG0742	ribosomal rna small subunit methyltransferase
SLLC_RS09555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SLLC_RS09560	COG1461	Dihydroxyacetone kinase
SLLC_RS09565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SLLC_RS09570	COG0351	phosphomethylpyrimidine kinase
SLLC_RS09590	COG1181	Belongs to the D-alanine--D-alanine ligase family
SLLC_RS09595	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SLLC_RS09605	COG1920	GTP binding
SLLC_RS09610	COG0776	regulation of translation
SLLC_RS09620	COG0066	3-isopropylmalate dehydratase activity
SLLC_RS09625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SLLC_RS09660	COG1011	Hydrolase
SLLC_RS09670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SLLC_RS09675	COG0179	Fumarylacetoacetate (FAA) hydrolase
SLLC_RS09685	COG5002	protein histidine kinase activity
SLLC_RS09690	COG2018	Roadblock/LC7 domain
SLLC_RS09710	COG2018	Roadblock/LC7 domain
SLLC_RS09745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLLC_RS09750	COG2353	YceI-like domain
SLLC_RS09760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLLC_RS09770	COG2957	Belongs to the agmatine deiminase family
SLLC_RS09775	COG0804	urea catabolic process
SLLC_RS09780	COG0831	urea catabolic process
SLLC_RS09780	COG0832	Belongs to the urease beta subunit family
SLLC_RS09790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SLLC_RS09795	COG0473	3-isopropylmalate dehydrogenase activity
SLLC_RS09800	COG0583	DNA-binding transcription factor activity
SLLC_RS09805	COG2130	NADP-dependent
SLLC_RS09810	COG3511	phospholipase C
SLLC_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS09845	COG0506	proline dehydrogenase activity
SLLC_RS09850	COG3835	regulator
SLLC_RS09860	COG0477	Major facilitator Superfamily
SLLC_RS09865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SLLC_RS09870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SLLC_RS09875	COG0440	acetolactate synthase activity
SLLC_RS09895	COG0667	Aldo Keto reductase
SLLC_RS09900	COG2133	pyrroloquinoline quinone binding
SLLC_RS09910	COG2197	response regulator
SLLC_RS09925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLLC_RS09930	COG2409	Drug exporters of the RND superfamily
SLLC_RS09945	COG2318	DinB family
SLLC_RS09965	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SLLC_RS09975	COG0154	amidase activity
SLLC_RS09980	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SLLC_RS09990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLLC_RS10015	COG0604	alcohol dehydrogenase
SLLC_RS10015	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS10015	COG3321	synthase
SLLC_RS10020	COG0482	sulfurtransferase activity
SLLC_RS10040	COG2860	membrane
SLLC_RS10045	COG4608	Belongs to the ABC transporter superfamily
SLLC_RS10050	COG0444	Belongs to the ABC transporter superfamily
SLLC_RS10055	COG0601	transmembrane transport
SLLC_RS10065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS10085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SLLC_RS10090	COG0509	glycine decarboxylation via glycine cleavage system
SLLC_RS10095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLLC_RS10105	COG1760	l-serine dehydratase
SLLC_RS10130	COG0310	cobalt ion transport
SLLC_RS10135	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
SLLC_RS10145	COG1122	ATPase activity
SLLC_RS10225	COG0297	glycogen (starch) synthase activity
SLLC_RS10230	COG0489	protein tyrosine kinase activity
SLLC_RS10270	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
SLLC_RS10275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLLC_RS10280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SLLC_RS10305	COG0058	SHG alpha-glucan phosphorylase activity
SLLC_RS10325	COG0366	Alpha amylase catalytic
SLLC_RS10330	COG0366	Alpha amylase catalytic
SLLC_RS10345	COG3118	belongs to the thioredoxin family
SLLC_RS10360	COG0205	6-phosphofructokinase activity
SLLC_RS10365	COG0857	belongs to the CobB CobQ family
SLLC_RS10365	COG0280	phosphate acetyltransferase
SLLC_RS10370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SLLC_RS10410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS10410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS10475	COG0183	Belongs to the thiolase family
SLLC_RS10495	COG1131	(ABC) transporter
SLLC_RS10530	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
SLLC_RS10545	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLLC_RS10560	COG4585	Histidine kinase
SLLC_RS10565	COG2197	response regulator
SLLC_RS10580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SLLC_RS10585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SLLC_RS10590	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SLLC_RS10595	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SLLC_RS10600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLLC_RS10605	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SLLC_RS10610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SLLC_RS10630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLLC_RS10635	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SLLC_RS10645	COG2890	protein-(glutamine-N5) methyltransferase activity
SLLC_RS10650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SLLC_RS10655	COG0254	rRNA binding
SLLC_RS10670	COG0083	homoserine kinase activity
SLLC_RS10675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SLLC_RS10680	COG0460	homoserine dehydrogenase
SLLC_RS10685	COG0019	diaminopimelate decarboxylase activity
SLLC_RS10690	COG0018	arginyl-trna synthetase
SLLC_RS10695	COG0745	RESPONSE REGULATOR receiver
SLLC_RS10725	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SLLC_RS10725	COG3608	succinylglutamate desuccinylase aspartoacylase
SLLC_RS10740	COG3285	dna ligase
SLLC_RS10740	COG1793	dna ligase
SLLC_RS10745	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SLLC_RS10765	COG2205	protein histidine kinase activity
SLLC_RS10775	COG1309	transcriptional regulator
SLLC_RS10810	COG0791	NLP P60 protein
SLLC_RS10810	COG3883	PFAM NLP P60 protein
SLLC_RS10835	COG5002	protein histidine kinase activity
SLLC_RS10850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SLLC_RS10865	COG2897	thiosulfate sulfurtransferase activity
SLLC_RS10880	COG0745	RESPONSE REGULATOR receiver
SLLC_RS10885	COG2205	protein histidine kinase activity
SLLC_RS10890	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLLC_RS10890	COG0567	Dehydrogenase, E1 component
SLLC_RS10955	COG4106	trans-aconitate 2-methyltransferase activity
SLLC_RS10960	COG1126	abc transporter atp-binding protein
SLLC_RS10965	COG0765	amino acid transport
SLLC_RS10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS10980	COG0604	alcohol dehydrogenase
SLLC_RS11010	COG5640	endopeptidase activity
SLLC_RS11030	COG0142	geranyltranstransferase activity
SLLC_RS11035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SLLC_RS11040	COG1959	2 iron, 2 sulfur cluster binding
SLLC_RS11045	COG1017	nitric oxide dioxygenase activity
SLLC_RS11045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SLLC_RS11060	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SLLC_RS11105	COG1309	transcriptional regulator
SLLC_RS11110	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS11115	COG0363	glucosamine-6-phosphate deaminase activity
SLLC_RS11120	COG1472	Belongs to the glycosyl hydrolase 3 family
SLLC_RS11125	COG0395	ABC-type sugar transport system, permease component
SLLC_RS11130	COG1175	transmembrane transport
SLLC_RS11135	COG2182	Extracellular solute-binding protein
SLLC_RS11140	COG2188	Transcriptional regulator
SLLC_RS11145	COG1966	Carbon starvation protein
SLLC_RS11175	COG0242	peptide deformylase activity
SLLC_RS11190	COG2199	diguanylate cyclase activity
SLLC_RS11190	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
SLLC_RS11195	COG5662	AntiSigma factor
SLLC_RS11200	COG1595	DNA-templated transcription, initiation
SLLC_RS11210	COG2135	peptidase activity
SLLC_RS11220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SLLC_RS11230	COG2076	Multidrug Resistance protein
SLLC_RS11240	COG0483	inositol monophosphate 1-phosphatase activity
SLLC_RS11250	COG0753	catalase activity
SLLC_RS11275	COG1615	UPF0182 protein
SLLC_RS11285	COG3480	Lon protease (S16) C-terminal proteolytic domain
SLLC_RS11340	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
SLLC_RS11385	COG0210	DNA helicase
SLLC_RS11405	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SLLC_RS11445	COG0601	transmembrane transport
SLLC_RS11450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS11495	COG0513	Belongs to the DEAD box helicase family
SLLC_RS11500	COG0596	Alpha beta hydrolase
SLLC_RS11510	COG2095	MarC family integral membrane protein
SLLC_RS11530	COG0598	Magnesium transport protein CorA
SLLC_RS11565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLLC_RS11570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLLC_RS11580	COG1595	DNA-templated transcription, initiation
SLLC_RS11595	COG1024	Enoyl-CoA hydratase
SLLC_RS11600	COG0519	Catalyzes the synthesis of GMP from XMP
SLLC_RS11615	COG1611	Belongs to the LOG family
SLLC_RS11620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLLC_RS11655	COG2197	response regulator
SLLC_RS11660	COG4585	Histidine kinase
SLLC_RS11670	COG1131	(ABC) transporter
SLLC_RS11685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SLLC_RS11695	COG4608	Belongs to the ABC transporter superfamily
SLLC_RS11700	COG0444	Belongs to the ABC transporter superfamily
SLLC_RS11705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS11715	COG4166	transmembrane transport
SLLC_RS11725	COG4608	Belongs to the ABC transporter superfamily
SLLC_RS11735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS11745	COG0747	negative chemotaxis
SLLC_RS11750	COG1217	gtp-binding protein TYPA
SLLC_RS11770	COG1053	succinate dehydrogenase
SLLC_RS11780	COG0515	serine threonine protein kinase
SLLC_RS11780	COG2815	serine threonine protein kinase
SLLC_RS11790	COG1842	Phage shock protein A
SLLC_RS11845	COG0697	spore germination
SLLC_RS11935	COG0012	GTP binding
SLLC_RS11950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SLLC_RS11965	COG1722	exodeoxyribonuclease VII activity
SLLC_RS11970	COG0778	Nitroreductase
SLLC_RS11995	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
SLLC_RS11995	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
SLLC_RS12020	COG0114	fumarate hydratase activity
SLLC_RS12035	COG4499	WXG100 protein secretion system (Wss), protein YukC
SLLC_RS12035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLLC_RS12055	COG0450	alkyl hydroperoxide reductase
SLLC_RS12060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SLLC_RS12080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SLLC_RS12085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SLLC_RS12090	COG0667	Aldo Keto reductase
SLLC_RS12130	COG0726	polysaccharide deacetylase
SLLC_RS12180	COG1309	transcriptional regulator
SLLC_RS12185	COG2885	chlorophyll binding
SLLC_RS12205	COG2197	response regulator
SLLC_RS12210	COG4585	Histidine kinase
SLLC_RS12240	COG2894	cell division
SLLC_RS12270	COG1414	Transcriptional regulator
SLLC_RS12280	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
SLLC_RS12395	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
SLLC_RS12415	COG0463	Glycosyl transferase, family 2
SLLC_RS12430	COG1331	Highly conserved protein containing a thioredoxin domain
SLLC_RS12445	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SLLC_RS12460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SLLC_RS12470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SLLC_RS12500	COG0501	Belongs to the peptidase M48B family
SLLC_RS12510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SLLC_RS12520	COG3119	arylsulfatase activity
SLLC_RS12525	COG1064	alcohol dehydrogenase
SLLC_RS12540	COG1136	(ABC) transporter
SLLC_RS12550	COG1376	ErfK ybiS ycfS ynhG family protein
SLLC_RS12565	COG2986	histidine ammonia-lyase
SLLC_RS12575	COG1024	Enoyl-CoA hydratase
SLLC_RS12580	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
SLLC_RS12590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLLC_RS12600	COG0424	maF-like protein
SLLC_RS12610	COG4770	biotin carboxylase activity
SLLC_RS12635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLLC_RS12645	COG2205	protein histidine kinase activity
SLLC_RS12650	COG0745	RESPONSE REGULATOR receiver
SLLC_RS12655	COG1595	DNA-templated transcription, initiation
SLLC_RS12670	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS12675	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS12710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SLLC_RS12730	COG0151	Belongs to the GarS family
SLLC_RS12745	COG0583	DNA-binding transcription factor activity
SLLC_RS12750	COG2814	Major facilitator Superfamily
SLLC_RS12785	COG1079	Belongs to the binding-protein-dependent transport system permease family
SLLC_RS12795	COG3845	ABC transporter
SLLC_RS12800	COG1744	ABC transporter substrate-binding protein PnrA-like
SLLC_RS12805	COG1473	amidohydrolase
SLLC_RS12805	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SLLC_RS12815	COG2089	acid synthase
SLLC_RS12825	COG1216	Glycosyl transferase, family 2
SLLC_RS12840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS12840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS12855	COG1595	DNA-templated transcription, initiation
SLLC_RS12865	COG2009	succinate dehydrogenase
SLLC_RS12875	COG1053	succinate dehydrogenase
SLLC_RS12880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SLLC_RS12890	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SLLC_RS12915	COG1309	transcriptional regulator
SLLC_RS12925	COG1846	Transcriptional regulator
SLLC_RS12935	COG1408	metallophosphoesterase
SLLC_RS12945	COG1686	Belongs to the peptidase S11 family
SLLC_RS12950	COG1295	ribonuclease BN
SLLC_RS12960	COG0180	Tryptophanyl-tRNA synthetase
SLLC_RS12965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SLLC_RS12970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SLLC_RS12975	COG0754	glutathionylspermidine amidase activity
SLLC_RS12990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SLLC_RS12995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SLLC_RS13015	COG0039	L-malate dehydrogenase activity
SLLC_RS13035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SLLC_RS13045	COG0138	bifunctional purine biosynthesis protein purh
SLLC_RS13075	COG0045	succinate-CoA ligase (ADP-forming) activity
SLLC_RS13080	COG3552	Protein containing von Willebrand factor type A (VWA) domain
SLLC_RS13090	COG0714	Associated with various cellular activities
SLLC_RS13110	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
SLLC_RS13135	COG0640	Transcriptional regulator
SLLC_RS13150	COG3693	PFAM glycoside hydrolase, family 10
SLLC_RS13150	COG2382	esterase
SLLC_RS13155	COG2197	response regulator
SLLC_RS13190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SLLC_RS13190	COG0519	Catalyzes the synthesis of GMP from XMP
SLLC_RS13210	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS13215	COG0515	serine threonine protein kinase
SLLC_RS13225	COG0515	serine threonine protein kinase
SLLC_RS13225	COG2815	serine threonine protein kinase
SLLC_RS13255	COG0516	GMP reductase activity
SLLC_RS13265	COG1595	DNA-templated transcription, initiation
SLLC_RS13270	COG2197	response regulator
SLLC_RS13280	COG0583	DNA-binding transcription factor activity
SLLC_RS13285	COG4221	oxidoreductase activity
SLLC_RS13300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SLLC_RS13310	COG0745	RESPONSE REGULATOR receiver
SLLC_RS13315	COG2205	protein histidine kinase activity
SLLC_RS13320	COG1316	TRANSCRIPTIONal
SLLC_RS13340	COG0726	polysaccharide deacetylase
SLLC_RS13345	COG0726	polysaccharide deacetylase
SLLC_RS13365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLLC_RS13390	COG0802	atpase or kinase
SLLC_RS13400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SLLC_RS13410	COG0736	holo-[acyl-carrier-protein] synthase activity
SLLC_RS13415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SLLC_RS13425	COG1072	(Pantothenic acid kinase))
SLLC_RS13435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLLC_RS13440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SLLC_RS13445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SLLC_RS13455	COG0488	(ABC) transporter
SLLC_RS13460	COG0101	tRNA pseudouridine synthase activity
SLLC_RS13465	COG0203	ribosomal protein L17
SLLC_RS13470	COG0202	RNA polymerase activity
SLLC_RS13475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SLLC_RS13480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SLLC_RS13485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SLLC_RS13490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
SLLC_RS13500	COG0563	adenylate kinase activity
SLLC_RS13505	COG0201	protein transport
SLLC_RS13510	COG0200	Binds to the 23S rRNA
SLLC_RS13515	COG1841	ribosomal large subunit assembly
SLLC_RS13520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SLLC_RS13525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SLLC_RS13530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SLLC_RS13535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SLLC_RS13540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SLLC_RS13545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SLLC_RS13550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SLLC_RS13555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SLLC_RS13560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SLLC_RS13565	COG0255	Belongs to the universal ribosomal protein uL29 family
SLLC_RS13570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SLLC_RS13575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SLLC_RS13580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SLLC_RS13585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SLLC_RS13590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SLLC_RS13595	COG0089	rRNA binding
SLLC_RS13600	COG0088	Forms part of the polypeptide exit tunnel
SLLC_RS13605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SLLC_RS13610	COG0051	transcription antitermination factor activity, RNA binding
SLLC_RS13620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SLLC_RS13625	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SLLC_RS13630	COG0049	tRNA binding
SLLC_RS13635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SLLC_RS13645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SLLC_RS13670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SLLC_RS13675	COG0085	RNA polymerase activity
SLLC_RS13680	COG0222	ribosome binding
SLLC_RS13685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SLLC_RS13715	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SLLC_RS13725	COG0436	Aminotransferase
SLLC_RS13730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SLLC_RS13740	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SLLC_RS13750	COG0477	Major facilitator Superfamily
SLLC_RS13765	COG2030	dehydratase
SLLC_RS13770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SLLC_RS13790	COG0702	epimerase
SLLC_RS13810	COG1666	GTP binding
SLLC_RS13825	COG3304	Inner membrane component domain
SLLC_RS13830	COG0501	Belongs to the peptidase M48B family
SLLC_RS13835	COG1007	ATP synthesis coupled electron transport
SLLC_RS13850	COG0713	ATP synthesis coupled electron transport
SLLC_RS13855	COG0839	Belongs to the complex I subunit 6 family
SLLC_RS13860	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS13865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SLLC_RS13870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS13875	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS13880	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS13900	COG0674	pyruvate-flavodoxin oxidoreductase activity
SLLC_RS13900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SLLC_RS13905	COG1013	pyruvate-flavodoxin oxidoreductase activity
SLLC_RS13910	COG1733	regulation of RNA biosynthetic process
SLLC_RS13915	COG0702	epimerase
SLLC_RS13945	COG0142	geranyltranstransferase activity
SLLC_RS13950	COG3104	oligopeptide transport
SLLC_RS13955	COG2936	dipeptidyl-peptidase activity
SLLC_RS13985	COG0561	phosphatase activity
SLLC_RS14010	COG1007	ATP synthesis coupled electron transport
SLLC_RS14020	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SLLC_RS14025	COG0713	ATP synthesis coupled electron transport
SLLC_RS14030	COG0839	Belongs to the complex I subunit 6 family
SLLC_RS14035	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS14040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SLLC_RS14045	COG1034	ATP synthesis coupled electron transport
SLLC_RS14050	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
SLLC_RS14060	COG0649	NAD binding
SLLC_RS14065	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS14070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SLLC_RS14080	COG0791	NLP P60 protein
SLLC_RS14100	COG2066	Belongs to the glutaminase family
SLLC_RS14105	COG2226	methyltransferase
SLLC_RS14120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SLLC_RS14135	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SLLC_RS14140	COG1278	Cold shock
SLLC_RS14155	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS14160	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SLLC_RS14165	COG2365	Tyrosine phosphatase family
SLLC_RS14200	COG0346	lactoylglutathione lyase activity
SLLC_RS14250	COG2205	protein histidine kinase activity
SLLC_RS14255	COG0745	RESPONSE REGULATOR receiver
SLLC_RS14270	COG0577	efflux transmembrane transporter activity
SLLC_RS14270	COG1136	(ABC) transporter
SLLC_RS14275	COG0577	efflux transmembrane transporter activity
SLLC_RS14275	COG1136	(ABC) transporter
SLLC_RS14285	COG0494	nUDIX hydrolase
SLLC_RS14300	COG1819	glycosyl
SLLC_RS14360	COG1024	Enoyl-CoA hydratase
SLLC_RS14380	COG2188	Transcriptional regulator
SLLC_RS14395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
SLLC_RS14395	COG0515	serine threonine protein kinase
SLLC_RS14405	COG1309	transcriptional regulator
SLLC_RS14415	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS14420	COG0183	Belongs to the thiolase family
SLLC_RS14430	COG0384	phenazine biosynthesis protein PhzF
SLLC_RS14460	COG2072	flavoprotein involved in K transport
SLLC_RS14470	COG1024	Enoyl-CoA hydratase
SLLC_RS14495	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
SLLC_RS14500	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS14505	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS14590	COG0640	Transcriptional regulator
SLLC_RS14615	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS14620	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS14630	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS14645	COG1652	LysM domain
SLLC_RS14695	COG1131	(ABC) transporter
SLLC_RS14775	COG2207	Transcriptional regulator
SLLC_RS14775	COG3708	Transcriptional regulator
SLLC_RS14795	COG4821	SIS domain
SLLC_RS14815	COG0259	pyridoxamine-phosphate oxidase activity
SLLC_RS14845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLLC_RS14885	COG0247	lactate metabolic process
SLLC_RS14885	COG0277	FAD linked oxidase domain protein
SLLC_RS14890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
SLLC_RS14910	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SLLC_RS14915	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
SLLC_RS14925	COG2252	PERMEase
SLLC_RS14950	COG1834	amidinotransferase
SLLC_RS14955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SLLC_RS14965	COG0667	Aldo Keto reductase
SLLC_RS14985	COG2268	Band 7 protein
SLLC_RS15005	COG2814	Major facilitator Superfamily
SLLC_RS15015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SLLC_RS15020	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
SLLC_RS15025	COG1278	Cold shock
SLLC_RS15055	COG1061	Type III restriction enzyme res subunit
SLLC_RS15070	COG3973	AAA domain
SLLC_RS15100	COG1737	Transcriptional regulator
SLLC_RS15105	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SLLC_RS15125	COG0135	phosphoribosylanthranilate isomerase activity
SLLC_RS15155	COG0463	Glycosyl transferase, family 2
SLLC_RS15175	COG0561	phosphatase activity
SLLC_RS15175	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLLC_RS15195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SLLC_RS15220	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SLLC_RS15245	COG3290	protein histidine kinase activity
SLLC_RS15300	COG3842	ATPase activity
SLLC_RS15310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SLLC_RS15320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLLC_RS15325	COG0215	cysteine-tRNA ligase activity
SLLC_RS15330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
SLLC_RS15335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SLLC_RS15340	COG1329	Transcriptional regulator
SLLC_RS15355	COG5002	protein histidine kinase activity
SLLC_RS15375	COG0588	phosphoglycerate mutase activity
SLLC_RS15390	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS15435	COG1733	regulation of RNA biosynthetic process
SLLC_RS15450	COG1595	DNA-templated transcription, initiation
SLLC_RS15460	COG2890	protein-(glutamine-N5) methyltransferase activity
SLLC_RS15465	COG4552	Acetyltransferase involved in intracellular survival and related
SLLC_RS15475	COG1490	D-aminoacyl-tRNA deacylase activity
SLLC_RS15485	COG0735	belongs to the Fur family
SLLC_RS15490	COG3485	protocatechuate 3,4-dioxygenase
SLLC_RS15530	COG0745	RESPONSE REGULATOR receiver
SLLC_RS15535	COG1609	Transcriptional regulator
SLLC_RS15540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLLC_RS15555	COG0823	Involved in the tonB-independent uptake of proteins
SLLC_RS15560	COG1309	transcriptional regulator
SLLC_RS15565	COG0596	Alpha beta hydrolase
SLLC_RS15570	COG0737	Belongs to the 5'-nucleotidase family
SLLC_RS15575	COG0456	acetyltransferase
SLLC_RS15605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SLLC_RS15610	COG0306	phosphate transporter
SLLC_RS15620	COG1937	Protein conserved in bacteria
SLLC_RS15645	COG0671	phosphoesterase, PA-phosphatase related
SLLC_RS15665	COG1280	lysine exporter protein (LysE YggA)
SLLC_RS15670	COG1357	PFAM Pentapeptide repeats (8 copies)
SLLC_RS15785	COG1252	NADH dehydrogenase
SLLC_RS15805	COG0579	oxidoreductase
SLLC_RS15820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SLLC_RS15835	COG0739	heme binding
SLLC_RS15835	COG0741	lytic transglycosylase activity
SLLC_RS15835	COG1196	nuclear chromosome segregation
SLLC_RS15855	COG0513	Belongs to the DEAD box helicase family
SLLC_RS15860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SLLC_RS15865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SLLC_RS15890	COG0785	Cytochrome C biogenesis protein
SLLC_RS15905	COG1643	Atp-dependent helicase
SLLC_RS15935	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SLLC_RS15945	COG3119	arylsulfatase activity
SLLC_RS15965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLLC_RS15970	COG0047	phosphoribosylformylglycinamidine synthase activity
SLLC_RS15975	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SLLC_RS16005	COG2197	response regulator
SLLC_RS16015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SLLC_RS16030	COG0151	Belongs to the GarS family
SLLC_RS16060	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
SLLC_RS16070	COG1349	DNA-binding transcription factor activity
SLLC_RS16075	COG0738	Major facilitator superfamily
SLLC_RS16085	COG0477	Major facilitator Superfamily
SLLC_RS16100	COG0477	Major facilitator Superfamily
SLLC_RS16110	COG3835	regulator
SLLC_RS16115	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
SLLC_RS16120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLLC_RS16120	COG2080	2 iron, 2 sulfur cluster binding
SLLC_RS16180	COG0433	COG0433 Predicted ATPase
SLLC_RS16195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SLLC_RS16240	COG1191	sigma factor activity
SLLC_RS16270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
SLLC_RS16280	COG2205	protein histidine kinase activity
SLLC_RS16285	COG0745	RESPONSE REGULATOR receiver
SLLC_RS16345	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS16350	COG1595	DNA-templated transcription, initiation
SLLC_RS16365	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS16375	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS16405	COG2855	membrane
SLLC_RS16415	COG0583	DNA-binding transcription factor activity
SLLC_RS16420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SLLC_RS16435	COG0653	protein targeting
SLLC_RS16455	COG0006	proline dipeptidase activity
SLLC_RS16485	COG2372	response to copper ion
SLLC_RS16490	COG2837	iron assimilation
SLLC_RS16500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SLLC_RS16505	COG0561	phosphatase activity
SLLC_RS16545	COG0789	Transcriptional regulator
SLLC_RS16555	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SLLC_RS16560	COG0326	Molecular chaperone. Has ATPase activity
SLLC_RS16575	COG0561	phosphatase activity
SLLC_RS16585	COG4988	ABC transporter
SLLC_RS16590	COG1294	oxidase, subunit
SLLC_RS16595	COG1271	oxidase subunit
SLLC_RS16605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SLLC_RS16610	COG1609	Transcriptional regulator
SLLC_RS16625	COG0667	Aldo Keto reductase
SLLC_RS16640	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SLLC_RS16665	COG0662	Cupin 2, conserved barrel domain protein
SLLC_RS16670	COG1950	PFAM Membrane protein of
SLLC_RS16675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SLLC_RS16680	COG0626	cystathionine gamma-synthase activity
SLLC_RS16710	COG0456	acetyltransferase
SLLC_RS16725	COG0305	Participates in initiation and elongation during chromosome replication
SLLC_RS16735	COG0359	binds to the 23S rRNA
SLLC_RS16740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SLLC_RS16745	COG0629	single-stranded DNA binding
SLLC_RS16750	COG0360	Binds together with S18 to 16S ribosomal RNA
SLLC_RS16775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLLC_RS16795	COG0617	tRNA 3'-terminal CCA addition
SLLC_RS16810	COG2815	serine threonine protein kinase
SLLC_RS16810	COG0515	serine threonine protein kinase
SLLC_RS16815	COG1595	DNA-templated transcription, initiation
SLLC_RS16825	COG0492	ferredoxin-NADP+ reductase activity
SLLC_RS16830	COG3118	belongs to the thioredoxin family
SLLC_RS16845	COG1192	Involved in chromosome partitioning
SLLC_RS16850	COG0357	Ribosomal RNA small subunit methyltransferase G
SLLC_RS16860	COG0706	membrane insertase activity
SLLC_RS16865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SLLC_RS16870	COG0594	ribonuclease P activity
SLLC_RS16880	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SLLC_RS16885	COG0592	DNA-directed DNA polymerase activity
SLLC_RS16890	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
SLLC_RS16895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SLLC_RS16900	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
SLLC_RS16910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SLLC_RS16935	COG0515	serine threonine protein kinase
SLLC_RS16960	COG1652	LysM domain
SLLC_RS16990	COG3764	Sortase (surface protein transpeptidase)
SLLC_RS17005	COG3764	Sortase (surface protein transpeptidase)
SLLC_RS17010	COG3764	Sortase (surface protein transpeptidase)
SLLC_RS17015	COG0515	serine threonine protein kinase
SLLC_RS17035	COG1716	ATPase activity
SLLC_RS17040	COG1716	ATPase activity
SLLC_RS17050	COG4585	Histidine kinase
SLLC_RS17055	COG2197	response regulator
SLLC_RS17080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SLLC_RS17085	COG2151	metal-sulfur cluster biosynthetic enzyme
SLLC_RS17090	COG3396	Phenylacetate-CoA oxygenase
SLLC_RS17095	COG3460	Phenylacetate-CoA oxygenase
SLLC_RS17100	COG3396	Phenylacetate-CoA oxygenase
SLLC_RS17135	COG1250	3-hydroxyacyl-CoA dehydrogenase
SLLC_RS17140	COG1309	transcriptional regulator
SLLC_RS17145	COG1522	sequence-specific DNA binding
SLLC_RS17165	COG3321	synthase
SLLC_RS17165	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS17165	COG0604	alcohol dehydrogenase
SLLC_RS17170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SLLC_RS17180	COG0746	molybdenum cofactor guanylyltransferase activity
SLLC_RS17195	COG1136	(ABC) transporter
SLLC_RS17195	COG4591	ABC-type transport system involved in lipoprotein release permease component
SLLC_RS17215	COG0515	serine threonine protein kinase
SLLC_RS17220	COG0515	serine threonine protein kinase
SLLC_RS17240	COG0022	dehydrogenase e1 component
SLLC_RS17245	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLLC_RS17270	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SLLC_RS17300	COG2271	Major facilitator Superfamily
SLLC_RS17350	COG2197	response regulator
SLLC_RS17360	COG1362	aminopeptidase activity
SLLC_RS17370	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS17420	COG0628	permease
SLLC_RS17430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SLLC_RS17445	COG2205	protein histidine kinase activity
SLLC_RS17455	COG1289	transmembrane transporter activity
SLLC_RS17525	COG1191	sigma factor activity
SLLC_RS17545	COG0667	Aldo Keto reductase
SLLC_RS17570	COG3973	AAA domain
SLLC_RS17580	COG0596	Alpha beta hydrolase
SLLC_RS17585	COG3226	Transcriptional regulator
SLLC_RS17615	COG2192	nodulation
SLLC_RS17650	COG2226	methyltransferase
SLLC_RS17670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SLLC_RS17685	COG1132	(ABC) transporter
SLLC_RS17695	COG2197	response regulator
SLLC_RS17755	COG5492	domain, Protein
SLLC_RS17755	COG4932	domain protein
SLLC_RS17800	COG0513	Belongs to the DEAD box helicase family
SLLC_RS17805	COG1278	Cold shock
SLLC_RS17815	COG0189	ligase activity
SLLC_RS17825	COG2197	response regulator
SLLC_RS17830	COG4585	Histidine kinase
SLLC_RS17845	COG0745	RESPONSE REGULATOR receiver
SLLC_RS17860	COG0717	Belongs to the dCTP deaminase family
SLLC_RS17875	COG0247	lactate metabolic process
SLLC_RS17875	COG2181	nitrate reductase activity
SLLC_RS17880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SLLC_RS17885	COG0443	Heat shock 70 kDa protein
SLLC_RS17890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SLLC_RS17895	COG0484	heat shock protein binding
SLLC_RS17900	COG0789	Transcriptional regulator
SLLC_RS17925	COG0542	response to heat
SLLC_RS17960	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SLLC_RS17975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SLLC_RS17980	COG0191	fructose-bisphosphate aldolase activity
SLLC_RS18005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS18040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SLLC_RS18055	COG1131	(ABC) transporter
SLLC_RS18060	COG3559	Exporter of polyketide antibiotics
SLLC_RS18065	COG2124	cytochrome p450
SLLC_RS18070	COG2197	response regulator
SLLC_RS18075	COG4585	Histidine kinase
SLLC_RS18080	COG2197	response regulator
SLLC_RS18085	COG4585	Histidine kinase
SLLC_RS18125	COG0693	protein deglycase activity
SLLC_RS18130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SLLC_RS18150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SLLC_RS18155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SLLC_RS18175	COG1595	DNA-templated transcription, initiation
SLLC_RS18200	COG0402	S-adenosylhomocysteine deaminase activity
SLLC_RS18230	COG1408	metallophosphoesterase
SLLC_RS18240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLLC_RS18250	COG0003	Pfam Anion-transporting ATPase
SLLC_RS18275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLLC_RS18310	COG2267	carboxylic ester hydrolase activity
SLLC_RS18320	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SLLC_RS18325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SLLC_RS18330	COG0659	secondary active sulfate transmembrane transporter activity
SLLC_RS18390	COG1205	dead DEAH box helicase
SLLC_RS18390	COG1111	helicase
SLLC_RS18395	COG1366	Belongs to the anti-sigma-factor antagonist family
SLLC_RS18400	COG2172	sigma factor antagonist activity
SLLC_RS18405	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
SLLC_RS18415	COG2890	protein-(glutamine-N5) methyltransferase activity
SLLC_RS18425	COG1754	DNA topoisomerase type I activity
SLLC_RS18425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SLLC_RS18430	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SLLC_RS18435	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SLLC_RS18530	COG1045	serine acetyltransferase
SLLC_RS18545	COG0151	Belongs to the GarS family
SLLC_RS18570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLLC_RS18570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLLC_RS18580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLLC_RS18605	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS18610	COG2318	DinB family
SLLC_RS18615	COG0789	Transcriptional regulator
SLLC_RS18620	COG0586	Pfam SNARE associated Golgi protein
SLLC_RS18630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SLLC_RS18635	COG2027	D-alanyl-D-alanine carboxypeptidase
SLLC_RS18645	COG0037	tRNA processing
SLLC_RS18650	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
SLLC_RS18660	COG0302	gtp cyclohydrolase
SLLC_RS18680	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
SLLC_RS18710	COG1174	glycine betaine transport
SLLC_RS18720	COG1732	Glycine betaine
SLLC_RS18740	COG0649	NAD binding
SLLC_RS18800	COG1674	ftsk spoiiie
SLLC_RS18810	COG2197	response regulator
SLLC_RS18835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SLLC_RS18845	COG2843	Capsule synthesis protein
SLLC_RS18860	COG0640	Transcriptional regulator
SLLC_RS18880	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SLLC_RS18885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
SLLC_RS18895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
SLLC_RS18925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SLLC_RS18945	COG0739	heme binding
SLLC_RS18955	COG2205	protein histidine kinase activity
SLLC_RS18960	COG0745	RESPONSE REGULATOR receiver
SLLC_RS18970	COG1595	DNA-templated transcription, initiation
SLLC_RS18975	COG1194	a g-specific adenine glycosylase
SLLC_RS18990	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
SLLC_RS19010	COG0248	Ppx GppA phosphatase
SLLC_RS19015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SLLC_RS19020	COG1082	Xylose isomerase domain protein TIM barrel
SLLC_RS19030	COG0129	dihydroxy-acid dehydratase activity
SLLC_RS19040	COG4991	sh3 domain protein
SLLC_RS19055	COG1129	ABC transporter
SLLC_RS19055	COG0842	Transport permease protein
SLLC_RS19065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SLLC_RS19070	COG0180	Tryptophanyl-tRNA synthetase
SLLC_RS19090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLLC_RS19095	COG2223	nitrite transmembrane transporter activity
SLLC_RS19100	COG0123	including yeast histone deacetylase and acetoin utilization protein
SLLC_RS19150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SLLC_RS19155	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SLLC_RS19160	COG0181	hydroxymethylbilane synthase activity
SLLC_RS19165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SLLC_RS19165	COG1648	precorrin-2 dehydrogenase activity
SLLC_RS19185	COG0113	porphobilinogen synthase activity
SLLC_RS19250	COG0018	arginyl-trna synthetase
SLLC_RS19260	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
SLLC_RS19280	COG1690	Belongs to the RtcB family
SLLC_RS19300	COG1742	UPF0060 membrane protein
SLLC_RS19315	COG1733	regulation of RNA biosynthetic process
SLLC_RS19335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SLLC_RS19340	COG0406	alpha-ribazole phosphatase activity
SLLC_RS19350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SLLC_RS19355	COG0785	Cytochrome C biogenesis protein
SLLC_RS19360	COG1333	cytochrome c biogenesis protein
SLLC_RS19365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SLLC_RS19390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SLLC_RS19400	COG0109	protoheme IX farnesyltransferase activity
SLLC_RS19415	COG0163	prenyltransferase activity
SLLC_RS19425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
SLLC_RS19440	COG1301	dicarboxylic acid transport
SLLC_RS19480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SLLC_RS19515	COG2207	Transcriptional regulator
SLLC_RS19525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SLLC_RS19550	COG1686	Belongs to the peptidase S11 family
SLLC_RS19580	COG0590	tRNA wobble adenosine to inosine editing
SLLC_RS19610	COG3384	dioxygenase
SLLC_RS19625	COG0477	Major facilitator Superfamily
SLLC_RS19630	COG1349	DNA-binding transcription factor activity
SLLC_RS19690	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS19695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SLLC_RS19715	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS19785	COG1970	mechanosensitive ion channel activity
SLLC_RS19800	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SLLC_RS19815	COG3263	regulation of cellular component size
SLLC_RS19825	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SLLC_RS19830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SLLC_RS19840	COG0315	cyclic pyranopterin monophosphate synthase activity
SLLC_RS19845	COG0521	Mo-molybdopterin cofactor biosynthetic process
SLLC_RS19845	COG0315	cyclic pyranopterin monophosphate synthase activity
SLLC_RS19850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLLC_RS19865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLLC_RS19875	COG0708	Exodeoxyribonuclease III
SLLC_RS19885	COG2072	flavoprotein involved in K transport
SLLC_RS19890	COG2267	carboxylic ester hydrolase activity
SLLC_RS19895	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS19905	COG0793	Belongs to the peptidase S41A family
SLLC_RS19905	COG4946	Tricorn protease homolog
SLLC_RS19915	COG2409	Drug exporters of the RND superfamily
SLLC_RS19925	COG0310	cobalt ion transport
SLLC_RS19935	COG1122	ATPase activity
SLLC_RS19940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SLLC_RS19945	COG0768	penicillin binding
SLLC_RS19950	COG2801	Transposase and inactivated derivatives
SLLC_RS19950	COG3415	Transposase
SLLC_RS19970	COG0084	hydrolase, TatD family'
SLLC_RS19975	COG3583	domain protein
SLLC_RS19975	COG3584	3D domain protein
SLLC_RS19980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SLLC_RS19985	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SLLC_RS19995	COG0488	(ABC) transporter
SLLC_RS20020	COG2197	response regulator
SLLC_RS20025	COG1846	Transcriptional regulator
SLLC_RS20030	COG4106	trans-aconitate 2-methyltransferase activity
SLLC_RS20035	COG1309	transcriptional regulator
SLLC_RS20045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
SLLC_RS20050	COG0193	aminoacyl-tRNA hydrolase activity
SLLC_RS20055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SLLC_RS20060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SLLC_RS20065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SLLC_RS20075	COG4585	Histidine kinase
SLLC_RS20105	COG0596	Alpha beta hydrolase
SLLC_RS20125	COG0477	Major facilitator Superfamily
SLLC_RS20130	COG1136	(ABC) transporter
SLLC_RS20135	COG0577	efflux transmembrane transporter activity
SLLC_RS20170	COG0515	serine threonine protein kinase
SLLC_RS20170	COG2815	serine threonine protein kinase
SLLC_RS20190	COG1017	nitric oxide dioxygenase activity
SLLC_RS20190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SLLC_RS20195	COG2124	cytochrome p450
SLLC_RS20210	COG0148	phosphopyruvate hydratase activity
SLLC_RS20240	COG1252	NADH dehydrogenase
SLLC_RS20245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SLLC_RS20250	COG0577	efflux transmembrane transporter activity
SLLC_RS20250	COG1136	(ABC) transporter
SLLC_RS20255	COG0577	efflux transmembrane transporter activity
SLLC_RS20255	COG1136	(ABC) transporter
SLLC_RS20285	COG0183	Belongs to the thiolase family
SLLC_RS20290	COG2755	lipolytic protein G-D-S-L family
SLLC_RS20320	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SLLC_RS20325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLLC_RS20335	COG1228	amidohydrolase
SLLC_RS20360	COG3104	oligopeptide transport
SLLC_RS20365	COG0745	RESPONSE REGULATOR receiver
SLLC_RS20370	COG2205	protein histidine kinase activity
SLLC_RS20405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
SLLC_RS20420	COG1216	Glycosyl transferase, family 2
SLLC_RS20430	COG1316	TRANSCRIPTIONal
SLLC_RS20455	COG1316	TRANSCRIPTIONal
SLLC_RS20460	COG1316	TRANSCRIPTIONal
SLLC_RS20465	COG1316	TRANSCRIPTIONal
SLLC_RS20485	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
SLLC_RS20485	COG0778	Nitroreductase
SLLC_RS20490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SLLC_RS20525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SLLC_RS20530	COG2835	tetraacyldisaccharide 4'-kinase activity
SLLC_RS20540	COG1482	cell wall glycoprotein biosynthetic process
SLLC_RS20550	COG0681	Belongs to the peptidase S26 family
SLLC_RS20555	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SLLC_RS20555	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SLLC_RS20555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SLLC_RS20560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SLLC_RS20605	COG0714	Associated with various cellular activities
SLLC_RS20625	COG0745	RESPONSE REGULATOR receiver
SLLC_RS20630	COG5000	phosphorelay sensor kinase activity
SLLC_RS20630	COG5002	protein histidine kinase activity
SLLC_RS20635	COG0823	Involved in the tonB-independent uptake of proteins
SLLC_RS20640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SLLC_RS20645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SLLC_RS20650	COG2197	response regulator
SLLC_RS20665	COG0653	protein targeting
SLLC_RS20680	COG0546	phosphoglycolate phosphatase activity
SLLC_RS20685	COG2902	Dehydrogenase
SLLC_RS20695	COG1134	teichoic acid transport
SLLC_RS20715	COG0395	ABC-type sugar transport system, permease component
SLLC_RS20720	COG1175	transmembrane transport
SLLC_RS20725	COG1653	transport
SLLC_RS20735	COG0515	serine threonine protein kinase
SLLC_RS20740	COG0515	serine threonine protein kinase
SLLC_RS20750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SLLC_RS20755	COG2884	Cell division ATP-binding protein ftsE
SLLC_RS20770	COG0793	Belongs to the peptidase S41A family
SLLC_RS20775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SLLC_RS20805	COG0583	DNA-binding transcription factor activity
SLLC_RS20820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SLLC_RS20845	COG3973	AAA domain
SLLC_RS20855	COG0776	regulation of translation
SLLC_RS20860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SLLC_RS20865	COG1678	Uncharacterized ACR, COG1678
SLLC_RS20875	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SLLC_RS20905	COG1404	Belongs to the peptidase S8 family
SLLC_RS20940	COG3654	unkown
SLLC_RS20985	COG3185	4-Hydroxyphenylpyruvate dioxygenase
SLLC_RS20995	COG0277	FAD linked oxidase domain protein
SLLC_RS21030	COG1335	isochorismatase
SLLC_RS21040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
SLLC_RS21050	COG1113	amino acid transport
SLLC_RS21070	COG3189	MarR family transcriptional regulator
SLLC_RS21080	COG1234	tRNA 3'-trailer cleavage
SLLC_RS21085	COG1263	PTS System
SLLC_RS21090	COG1263	PTS System
SLLC_RS21095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SLLC_RS21100	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SLLC_RS21110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SLLC_RS21140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLLC_RS21155	COG4555	ABC transporter
SLLC_RS21165	COG2733	membrane
SLLC_RS21230	COG3764	Sortase (surface protein transpeptidase)
SLLC_RS21240	COG0706	membrane insertase activity
SLLC_RS21250	COG0673	inositol 2-dehydrogenase activity
SLLC_RS21255	COG1940	carbohydrate kinase activity
SLLC_RS21265	COG2188	Transcriptional regulator
SLLC_RS21270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SLLC_RS21335	COG3397	chitin binding
SLLC_RS21340	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS21355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS21415	COG0406	alpha-ribazole phosphatase activity
SLLC_RS21440	COG0745	RESPONSE REGULATOR receiver
SLLC_RS21480	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
SLLC_RS21485	COG4977	sequence-specific DNA binding
SLLC_RS21495	COG0589	response to stress
SLLC_RS21505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SLLC_RS21545	COG3486	L-lysine 6-monooxygenase (NADPH) activity
SLLC_RS21550	COG0076	glutamate decarboxylase activity
SLLC_RS21555	COG2375	cellular response to nickel ion
SLLC_RS21565	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS21580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
SLLC_RS21585	COG1309	transcriptional regulator
SLLC_RS21600	COG1946	Acyl-CoA thioesterase
SLLC_RS21625	COG0028	Belongs to the TPP enzyme family
SLLC_RS21650	COG1472	Belongs to the glycosyl hydrolase 3 family
SLLC_RS21675	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SLLC_RS21700	COG0673	inositol 2-dehydrogenase activity
SLLC_RS21715	COG3718	enzyme involved in inositol metabolism
SLLC_RS21720	COG3962	Belongs to the TPP enzyme family
SLLC_RS21750	COG2091	lysine biosynthetic process via aminoadipic acid
SLLC_RS21785	COG0629	single-stranded DNA binding
SLLC_RS21825	COG2346	COG2346, Truncated hemoglobins
SLLC_RS21830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SLLC_RS21860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS21875	COG1486	melibiose metabolic process
SLLC_RS21880	COG0395	ABC-type sugar transport system, permease component
SLLC_RS21885	COG1175	transmembrane transport
SLLC_RS21900	COG0668	transmembrane transport
SLLC_RS21910	COG3525	Glycosyl hydrolase, family 20, catalytic domain
SLLC_RS21910	COG3291	Pkd domain containing protein
SLLC_RS21930	COG1846	Transcriptional regulator
SLLC_RS21935	COG0697	spore germination
SLLC_RS21965	COG2234	aminopeptidase activity
SLLC_RS21980	COG2514	catechol 2,3-dioxygenase activity
SLLC_RS22000	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SLLC_RS22005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SLLC_RS22010	COG1113	amino acid transport
SLLC_RS22020	COG1113	amino acid transport
SLLC_RS22030	COG1113	amino acid transport
SLLC_RS22045	COG4552	Acetyltransferase involved in intracellular survival and related
SLLC_RS22085	COG0544	peptidyl-prolyl cis-trans isomerase activity
SLLC_RS22090	COG0740	serine-type endopeptidase activity
SLLC_RS22095	COG0740	serine-type endopeptidase activity
SLLC_RS22100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SLLC_RS22115	COG0525	valine-tRNA ligase activity
SLLC_RS22125	COG1077	Cell shape determining protein MreB Mrl
SLLC_RS22130	COG0285	dihydrofolate synthase activity
SLLC_RS22140	COG0105	UTP biosynthetic process
SLLC_RS22145	COG1077	Cell shape determining protein MreB Mrl
SLLC_RS22160	COG0768	penicillin binding
SLLC_RS22165	COG0772	Belongs to the SEDS family
SLLC_RS22190	COG1530	ribonuclease E activity
SLLC_RS22195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SLLC_RS22200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SLLC_RS22205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SLLC_RS22210	COG1215	transferase activity, transferring glycosyl groups
SLLC_RS22220	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS22225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLLC_RS22230	COG0463	Glycosyl transferase, family 2
SLLC_RS22240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
SLLC_RS22250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
SLLC_RS22265	COG0501	Belongs to the peptidase M48B family
SLLC_RS22275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SLLC_RS22285	COG0799	negative regulation of ribosome biogenesis
SLLC_RS22290	COG0588	phosphoglycerate mutase activity
SLLC_RS22310	COG0495	leucyl-tRNA aminoacylation
SLLC_RS22320	COG1307	EDD domain protein, DegV family
SLLC_RS22325	COG1555	photosystem II stabilization
SLLC_RS22325	COG1596	polysaccharide export
SLLC_RS22335	COG2353	YceI-like domain
SLLC_RS22355	COG0268	Binds directly to 16S ribosomal RNA
SLLC_RS22360	COG0481	GTPase activity
SLLC_RS22390	COG1420	regulation of RNA biosynthetic process
SLLC_RS22395	COG0484	heat shock protein binding
SLLC_RS22410	COG0537	adenosine 5'-monophosphoramidase activity
SLLC_RS22415	COG1234	tRNA 3'-trailer cleavage
SLLC_RS22430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SLLC_RS22440	COG2315	Protein conserved in bacteria
SLLC_RS22470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SLLC_RS22495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLLC_RS22500	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS22515	COG1381	Involved in DNA repair and RecF pathway recombination
SLLC_RS22520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SLLC_RS22535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SLLC_RS22540	COG1121	(ABC) transporter
SLLC_RS22545	COG3443	Belongs to the bacterial solute-binding protein 9 family
SLLC_RS22545	COG0803	Belongs to the bacterial solute-binding protein 9 family
SLLC_RS22550	COG0423	glycine-tRNA ligase activity
SLLC_RS22560	COG1309	transcriptional regulator
SLLC_RS22565	COG0667	Aldo Keto reductase
SLLC_RS22580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLLC_RS22580	COG0574	Belongs to the PEP-utilizing enzyme family
SLLC_RS22600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLLC_RS22600	COG2146	nitrite reductase [NAD(P)H] activity
SLLC_RS22605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SLLC_RS22610	COG1017	nitric oxide dioxygenase activity
SLLC_RS22610	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SLLC_RS22635	COG2205	protein histidine kinase activity
SLLC_RS22650	COG0358	DNA primase activity
SLLC_RS22660	COG0232	Belongs to the dGTPase family. Type 2 subfamily
SLLC_RS22670	COG2949	membrane
SLLC_RS22685	COG0243	molybdopterin cofactor binding
SLLC_RS22715	COG1070	Carbohydrate kinase
SLLC_RS22750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
SLLC_RS22770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SLLC_RS22770	COG0825	malonyl-CoA metabolic process
SLLC_RS22780	COG1522	sequence-specific DNA binding
SLLC_RS22795	COG1077	Cell shape determining protein MreB Mrl
SLLC_RS22875	COG2130	NADP-dependent
SLLC_RS22880	COG1764	response to oxidative stress
SLLC_RS22895	COG1733	regulation of RNA biosynthetic process
SLLC_RS22910	COG1309	transcriptional regulator
SLLC_RS22930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
SLLC_RS22935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLLC_RS22940	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLLC_RS22965	COG0789	Transcriptional regulator
SLLC_RS22970	COG0667	Aldo Keto reductase
SLLC_RS22985	COG1309	transcriptional regulator
SLLC_RS22990	COG0477	Major facilitator Superfamily
SLLC_RS23000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SLLC_RS23005	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SLLC_RS23050	COG1358	cellular component organization or biogenesis
SLLC_RS23185	COG2124	cytochrome p450
SLLC_RS23190	COG0183	Belongs to the thiolase family
SLLC_RS23205	COG3845	ABC transporter
SLLC_RS23245	COG1309	transcriptional regulator
SLLC_RS23250	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS23285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS23295	COG0860	N-Acetylmuramoyl-L-alanine amidase
SLLC_RS23300	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
SLLC_RS23305	COG2801	Transposase and inactivated derivatives
SLLC_RS23305	COG3415	Transposase
SLLC_RS23315	COG0515	serine threonine protein kinase
SLLC_RS23315	COG2815	serine threonine protein kinase
SLLC_RS23350	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS23355	COG0183	Belongs to the thiolase family
SLLC_RS23375	COG2030	dehydratase
SLLC_RS23385	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS23390	COG1011	Hydrolase
SLLC_RS23400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SLLC_RS23445	COG3022	response to hydroperoxide
SLLC_RS23460	COG1834	amidinotransferase
SLLC_RS23470	COG2814	Major facilitator Superfamily
SLLC_RS23475	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS23480	COG0463	Glycosyl transferase, family 2
SLLC_RS23490	COG0672	)-iron permease
SLLC_RS23495	COG2837	iron assimilation
SLLC_RS23505	COG1120	ATPase activity
SLLC_RS23515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SLLC_RS23565	COG0789	Transcriptional regulator
SLLC_RS23570	COG1994	Peptidase M50
SLLC_RS23590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SLLC_RS23600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SLLC_RS23600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLLC_RS23635	COG0174	glutamine synthetase
SLLC_RS23650	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
SLLC_RS23670	COG1228	amidohydrolase
SLLC_RS23680	COG1609	Transcriptional regulator
SLLC_RS23685	COG0366	Alpha amylase catalytic
SLLC_RS23695	COG1175	transmembrane transport
SLLC_RS23705	COG0366	Alpha amylase catalytic
SLLC_RS23755	COG2365	Tyrosine phosphatase family
SLLC_RS23775	COG0745	RESPONSE REGULATOR receiver
SLLC_RS23850	COG0321	lipoyl(octanoyl) transferase activity
SLLC_RS23855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SLLC_RS23890	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS23900	COG0515	serine threonine protein kinase
SLLC_RS23900	COG2815	serine threonine protein kinase
SLLC_RS23905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
SLLC_RS23915	COG0508	dehydrogenase complex catalyzes the overall conversion of
SLLC_RS23920	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SLLC_RS23925	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SLLC_RS23955	COG4585	Histidine kinase
SLLC_RS23965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SLLC_RS23965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SLLC_RS23970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SLLC_RS23985	COG2226	methyltransferase
SLLC_RS24010	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
SLLC_RS24015	COG2197	response regulator
SLLC_RS24020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SLLC_RS24030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
SLLC_RS24050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLLC_RS24060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SLLC_RS24065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SLLC_RS24075	COG1376	ErfK ybiS ycfS ynhG family protein
SLLC_RS24085	COG1845	cytochrome c oxidase, subunit III
SLLC_RS24090	COG2010	Cytochrome c
SLLC_RS24095	COG0723	plastoquinol--plastocyanin reductase activity
SLLC_RS24100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
SLLC_RS24105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SLLC_RS24110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SLLC_RS24150	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS24175	COG0003	Pfam Anion-transporting ATPase
SLLC_RS24185	COG1940	carbohydrate kinase activity
SLLC_RS24210	COG4585	Histidine kinase
SLLC_RS24215	COG2197	response regulator
SLLC_RS24220	COG0205	6-phosphofructokinase activity
SLLC_RS24225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SLLC_RS24235	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
SLLC_RS24245	COG2193	ferroxidase activity
SLLC_RS24250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SLLC_RS24260	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SLLC_RS24265	COG0515	serine threonine protein kinase
SLLC_RS24265	COG2815	serine threonine protein kinase
SLLC_RS24285	COG2022	thiamine diphosphate biosynthetic process
SLLC_RS24295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SLLC_RS24295	COG2022	thiamine diphosphate biosynthetic process
SLLC_RS24310	COG0352	thiamine-phosphate diphosphorylase activity
SLLC_RS24325	COG1233	COG1233 Phytoene dehydrogenase and related
SLLC_RS24350	COG1126	abc transporter atp-binding protein
SLLC_RS24360	COG1309	transcriptional regulator
SLLC_RS24375	COG0714	Associated with various cellular activities
SLLC_RS24385	COG0275	rRNA processing
SLLC_RS24400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SLLC_RS24410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SLLC_RS24415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SLLC_RS24425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLLC_RS24430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SLLC_RS24435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SLLC_RS24450	COG1799	cell septum assembly
SLLC_RS24460	COG3599	regulation of cell shape
SLLC_RS24465	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SLLC_RS24475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SLLC_RS24495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLLC_RS24500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SLLC_RS24510	COG2205	protein histidine kinase activity
SLLC_RS24550	COG0587	DNA-directed DNA polymerase activity
SLLC_RS24560	COG1432	Conserved Protein
SLLC_RS24580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SLLC_RS24595	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SLLC_RS24600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SLLC_RS24605	COG0131	Imidazoleglycerol-phosphate dehydratase
SLLC_RS24615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SLLC_RS24620	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SLLC_RS24625	COG0251	oxidation-reduction process
SLLC_RS24630	COG0107	imidazoleglycerol-phosphate synthase activity
SLLC_RS24640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
SLLC_RS24665	COG0134	indole-3-glycerol-phosphate synthase activity
SLLC_RS24670	COG0133	tryptophan synthase activity
SLLC_RS24675	COG0159	tryptophan synthase activity
SLLC_RS24685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SLLC_RS24690	COG2301	Belongs to the HpcH HpaI aldolase family
SLLC_RS24695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLLC_RS24700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SLLC_RS24730	COG0069	glutamate synthase activity
SLLC_RS24730	COG0070	glutamate synthase
SLLC_RS24730	COG0067	glutamate synthase
SLLC_RS24785	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS24790	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS24795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SLLC_RS24805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS24815	COG0657	acetylesterase activity
SLLC_RS24845	COG0598	Magnesium transport protein CorA
SLLC_RS24860	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS24865	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS24870	COG1024	Enoyl-CoA hydratase
SLLC_RS24875	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS24880	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS24885	COG1309	transcriptional regulator
SLLC_RS24890	COG0183	Belongs to the thiolase family
SLLC_RS24900	COG1278	Cold shock
SLLC_RS24910	COG2365	Tyrosine phosphatase family
SLLC_RS24930	COG1024	Enoyl-CoA hydratase
SLLC_RS24940	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS24960	COG0596	Alpha beta hydrolase
SLLC_RS24965	COG0517	IMP dehydrogenase activity
SLLC_RS24965	COG0516	GMP reductase activity
SLLC_RS24990	COG0739	heme binding
SLLC_RS24995	COG0739	heme binding
SLLC_RS25000	COG3971	2-oxopent-4-enoate hydratase activity
SLLC_RS25010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SLLC_RS25035	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS25040	COG2267	carboxylic ester hydrolase activity
SLLC_RS25050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SLLC_RS25055	COG1053	succinate dehydrogenase
SLLC_RS25080	COG2197	response regulator
SLLC_RS25090	COG1605	Chorismate mutase
SLLC_RS25090	COG0287	Prephenate dehydrogenase
SLLC_RS25120	COG0737	Belongs to the 5'-nucleotidase family
SLLC_RS25190	COG2050	protein possibly involved in aromatic compounds catabolism
SLLC_RS25225	COG1643	Atp-dependent helicase
SLLC_RS25230	COG1073	alpha beta
SLLC_RS25230	COG2226	methyltransferase
SLLC_RS25235	COG0539	negative regulation of cytoplasmic translation
SLLC_RS25245	COG0237	dephospho-CoA kinase activity
SLLC_RS25270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SLLC_RS25295	COG1846	Transcriptional regulator
SLLC_RS25320	COG2313	pseudouridylate synthase activity
SLLC_RS25335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SLLC_RS25340	COG0584	glycerophosphoryl diester phosphodiesterase
SLLC_RS25345	COG0556	nucleotide-excision repair
SLLC_RS25365	COG0477	Major facilitator Superfamily
SLLC_RS25380	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SLLC_RS25425	COG0322	excinuclease ABC activity
SLLC_RS25430	COG1660	Displays ATPase and GTPase activities
SLLC_RS25440	COG1481	regulation of sporulation
SLLC_RS25450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SLLC_RS25455	COG0126	phosphoglycerate kinase activity
SLLC_RS25460	COG0149	triose-phosphate isomerase activity
SLLC_RS25465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SLLC_RS25475	COG0166	Belongs to the GPI family
SLLC_RS25480	COG0363	glucosamine-6-phosphate deaminase activity
SLLC_RS25495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SLLC_RS25505	COG0109	protoheme IX farnesyltransferase activity
SLLC_RS25520	COG1612	heme a metabolic process
SLLC_RS25550	COG0719	Fe-S assembly protein
SLLC_RS25560	COG0396	ATPase activity
SLLC_RS25565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SLLC_RS25570	COG0822	iron-sulfur transferase activity
SLLC_RS25575	COG2151	metal-sulfur cluster biosynthetic enzyme
SLLC_RS25595	COG2076	Multidrug Resistance protein
SLLC_RS25600	COG3226	Transcriptional regulator
SLLC_RS25615	COG2171	N-acyltransferase activity
SLLC_RS25680	COG4585	Histidine kinase
SLLC_RS25685	COG2197	response regulator
SLLC_RS25705	COG0156	8-amino-7-oxononanoate synthase activity
SLLC_RS25710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SLLC_RS25735	COG1797	cobyrinic acid a,c-diamide synthase activity
SLLC_RS25750	COG1492	cobalamin metabolic process
SLLC_RS25755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
SLLC_RS25790	COG0488	(ABC) transporter
SLLC_RS25800	COG1024	Enoyl-CoA hydratase
SLLC_RS25805	COG1302	Protein conserved in bacteria
SLLC_RS25890	COG1063	alcohol dehydrogenase
SLLC_RS25905	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SLLC_RS25910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLLC_RS25930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SLLC_RS25945	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS25950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SLLC_RS25960	COG2186	Transcriptional regulator
SLLC_RS25980	COG3483	tryptophan 2,3-dioxygenase activity
SLLC_RS25990	COG0436	Aminotransferase
SLLC_RS25995	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS26000	COG0560	Phosphoserine phosphatase
SLLC_RS26000	COG3830	Belongs to the UPF0237 family
SLLC_RS26005	COG1131	(ABC) transporter
SLLC_RS26005	COG1716	ATPase activity
SLLC_RS26005	COG0842	Transport permease protein
SLLC_RS26020	COG2197	response regulator
SLLC_RS26035	COG1119	ATPase activity
SLLC_RS26060	COG1881	PFAM PEBP family protein
SLLC_RS26070	COG2094	Belongs to the DNA glycosylase MPG family
SLLC_RS26105	COG0647	UMP catabolic process
SLLC_RS26110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLLC_RS26115	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SLLC_RS26120	COG1120	ATPase activity
SLLC_RS26140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SLLC_RS26145	COG0497	DNA recombination
SLLC_RS26150	COG0297	glycogen (starch) synthase activity
SLLC_RS26165	COG3387	PFAM Glycoside hydrolase 15-related
SLLC_RS26170	COG0504	CTP synthase activity
SLLC_RS26175	COG0494	nUDIX hydrolase
SLLC_RS26185	COG0686	Belongs to the AlaDH PNT family
SLLC_RS26200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SLLC_RS26205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SLLC_RS26210	COG1187	pseudouridine synthase activity
SLLC_RS26225	COG0494	nUDIX hydrolase
SLLC_RS26235	COG3541	Predicted nucleotidyltransferase
SLLC_RS26265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SLLC_RS26275	COG1160	GTP binding
SLLC_RS26290	COG3583	domain protein
SLLC_RS26300	COG0671	phosphoesterase, PA-phosphatase related
SLLC_RS26310	COG0477	Major facilitator Superfamily
SLLC_RS26315	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS26320	COG1799	cell septum assembly
SLLC_RS26365	COG0641	radical SAM
SLLC_RS26400	COG0596	Alpha beta hydrolase
SLLC_RS26425	COG0587	DNA-directed DNA polymerase activity
SLLC_RS26455	COG1725	Transcriptional regulator
SLLC_RS26465	COG2755	lipolytic protein G-D-S-L family
SLLC_RS26470	COG0515	serine threonine protein kinase
SLLC_RS26480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
SLLC_RS26510	COG2188	Transcriptional regulator
SLLC_RS26515	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
SLLC_RS26535	COG1309	transcriptional regulator
SLLC_RS26540	COG3383	formate dehydrogenase (NAD+) activity
SLLC_RS26545	COG2851	Citrate transporter
SLLC_RS26565	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS26600	COG3876	Protein conserved in bacteria
SLLC_RS26605	COG0300	oxidoreductase activity
SLLC_RS26610	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS26625	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS26650	COG2149	membrane
SLLC_RS26655	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
SLLC_RS26680	COG1113	amino acid transport
SLLC_RS26725	COG2175	clavaminate synthase activity
SLLC_RS26735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SLLC_RS26765	COG0667	Aldo Keto reductase
SLLC_RS26770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS26780	COG0598	Magnesium transport protein CorA
SLLC_RS26800	COG0215	cysteine-tRNA ligase activity
SLLC_RS26810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SLLC_RS26815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SLLC_RS26820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SLLC_RS26825	COG1414	Transcriptional regulator
SLLC_RS26830	COG0646	methionine synthase
SLLC_RS26830	COG1410	methionine synthase
SLLC_RS26840	COG4166	transmembrane transport
SLLC_RS26850	COG2197	response regulator
SLLC_RS26860	COG0517	IMP dehydrogenase activity
SLLC_RS26860	COG1994	Peptidase M50
SLLC_RS26880	COG1222	aaa ATPase
SLLC_RS26885	COG4122	O-methyltransferase activity
SLLC_RS26900	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SLLC_RS26905	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SLLC_RS26910	COG1609	Transcriptional regulator
SLLC_RS26920	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SLLC_RS26955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SLLC_RS26960	COG0805	protein transport
SLLC_RS26975	COG1309	transcriptional regulator
SLLC_RS26980	COG0564	pseudouridine synthase activity
SLLC_RS26995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SLLC_RS27030	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SLLC_RS27035	COG1113	amino acid transport
SLLC_RS27045	COG0174	glutamine synthetase
SLLC_RS27050	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS27055	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS27090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SLLC_RS27095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SLLC_RS27100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SLLC_RS27105	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SLLC_RS27110	COG5002	protein histidine kinase activity
SLLC_RS27115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SLLC_RS27120	COG0072	phenylalanine-tRNA ligase activity
SLLC_RS27120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SLLC_RS27145	COG1649	PFAM Uncharacterised BCR, COG1649
SLLC_RS27180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SLLC_RS27185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SLLC_RS27190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SLLC_RS27195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SLLC_RS27200	COG1438	arginine binding
SLLC_RS27215	COG0165	Argininosuccinate lyase
SLLC_RS27230	COG0477	Major facilitator Superfamily
SLLC_RS27240	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS27240	COG0204	Acyl-transferase
SLLC_RS27270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLLC_RS27275	COG2011	ABC-type metal ion transport system permease component
SLLC_RS27280	COG1464	Belongs to the NlpA lipoprotein family
SLLC_RS27295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
SLLC_RS27300	COG1648	precorrin-2 dehydrogenase activity
SLLC_RS27300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SLLC_RS27355	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SLLC_RS27365	COG0456	acetyltransferase
SLLC_RS27365	COG0454	-acetyltransferase
SLLC_RS27420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SLLC_RS27440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SLLC_RS27465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SLLC_RS27470	COG1560	Kdo2-lipid A biosynthetic process
SLLC_RS27475	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS27485	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SLLC_RS27490	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SLLC_RS27495	COG0217	transcriptional regulatory protein
SLLC_RS27500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SLLC_RS27505	COG0632	four-way junction helicase activity
SLLC_RS27510	COG2255	four-way junction helicase activity
SLLC_RS27520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLLC_RS27525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SLLC_RS27530	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SLLC_RS27535	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
SLLC_RS27545	COG1196	nuclear chromosome segregation
SLLC_RS27550	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SLLC_RS27560	COG0124	histidyl-tRNA synthetase
SLLC_RS27570	COG1131	(ABC) transporter
SLLC_RS27595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SLLC_RS27615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SLLC_RS27620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SLLC_RS27630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SLLC_RS27640	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SLLC_RS27645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SLLC_RS27650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SLLC_RS27655	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
SLLC_RS27665	COG0006	proline dipeptidase activity
SLLC_RS27670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SLLC_RS27675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SLLC_RS27685	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SLLC_RS27690	COG0540	Belongs to the ATCase OTCase family
SLLC_RS27695	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SLLC_RS27705	COG0505	Belongs to the CarA family
SLLC_RS27710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SLLC_RS27715	COG0167	dihydroorotate dehydrogenase activity
SLLC_RS27720	COG0284	orotidine-5'-phosphate decarboxylase activity
SLLC_RS27730	COG0194	GDP metabolic process
SLLC_RS27745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SLLC_RS27760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SLLC_RS27770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS27770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SLLC_RS27775	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SLLC_RS27780	COG2390	Transcriptional regulator
SLLC_RS27800	COG2346	COG2346, Truncated hemoglobins
SLLC_RS27815	COG0492	ferredoxin-NADP+ reductase activity
SLLC_RS27830	COG0028	Belongs to the TPP enzyme family
SLLC_RS27850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SLLC_RS27855	COG0693	protein deglycase activity
SLLC_RS27870	COG1366	Belongs to the anti-sigma-factor antagonist family
SLLC_RS27890	COG2208	phosphoserine phosphatase activity
SLLC_RS27890	COG2770	Histidine kinase
SLLC_RS27895	COG0489	protein tyrosine kinase activity
SLLC_RS27905	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS27945	COG3548	integral membrane protein
SLLC_RS27965	COG3275	phosphorelay sensor kinase activity
SLLC_RS27970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SLLC_RS28000	COG0531	amino acid
SLLC_RS28020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS28030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS28050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SLLC_RS28070	COG2233	PERMEase
SLLC_RS28075	COG0738	Major facilitator superfamily
SLLC_RS28080	COG1940	carbohydrate kinase activity
SLLC_RS28080	COG1846	Transcriptional regulator
SLLC_RS28100	COG3201	nicotinamide mononucleotide transporter
SLLC_RS28105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLLC_RS28105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SLLC_RS28110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SLLC_RS28115	COG0140	phosphoribosyl-ATP diphosphatase activity
SLLC_RS28120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SLLC_RS28140	COG3415	Transposase
SLLC_RS28140	COG2801	Transposase and inactivated derivatives
SLLC_RS28185	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS28225	COG0463	Glycosyl transferase, family 2
SLLC_RS28240	COG2270	Major facilitator Superfamily
SLLC_RS28280	COG1984	allophanate hydrolase subunit 2
SLLC_RS28285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SLLC_RS28290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SLLC_RS28320	COG0642	Histidine kinase
SLLC_RS28325	COG2018	Roadblock/LC7 domain
SLLC_RS28340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SLLC_RS28355	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
SLLC_RS28380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SLLC_RS28390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLLC_RS28420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SLLC_RS28460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SLLC_RS28470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SLLC_RS28470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SLLC_RS28500	COG1695	Transcriptional regulator
SLLC_RS28515	COG0697	spore germination
SLLC_RS28530	COG0697	spore germination
SLLC_RS28545	COG1335	isochorismatase
SLLC_RS28570	COG0747	negative chemotaxis
SLLC_RS28575	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SLLC_RS28590	COG2318	DinB family
SLLC_RS28600	COG0815	Transfers the fatty acyl group on membrane lipoproteins
SLLC_RS28615	COG1968	undecaprenyl-diphosphatase activity
SLLC_RS28635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SLLC_RS28675	COG0110	maltose O-acetyltransferase activity
SLLC_RS28690	COG1832	CoA-binding protein
SLLC_RS28695	COG1739	Uncharacterized protein family UPF0029
SLLC_RS28705	COG0420	3'-5' exonuclease activity
SLLC_RS28710	COG0419	ATPase involved in DNA repair
SLLC_RS28715	COG1522	sequence-specific DNA binding
SLLC_RS28745	COG2188	Transcriptional regulator
SLLC_RS28755	COG1940	carbohydrate kinase activity
SLLC_RS28760	COG2197	response regulator
SLLC_RS28765	COG4585	Histidine kinase
SLLC_RS28790	COG3896	Chloramphenicol phosphotransferase-like protein
SLLC_RS28800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SLLC_RS28835	COG2226	methyltransferase
SLLC_RS28840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SLLC_RS28845	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SLLC_RS28850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SLLC_RS28855	COG0156	8-amino-7-oxononanoate synthase activity
SLLC_RS28875	COG0831	urea catabolic process
SLLC_RS28880	COG0832	Belongs to the urease beta subunit family
SLLC_RS28885	COG0804	urea catabolic process
SLLC_RS28890	COG0830	nickel cation binding
SLLC_RS28895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SLLC_RS28900	COG0829	nickel cation binding
SLLC_RS28910	COG0204	Acyl-transferase
SLLC_RS28925	COG0205	6-phosphofructokinase activity
SLLC_RS28930	COG3442	glutamine amidotransferase
SLLC_RS28940	COG0242	peptide deformylase activity
SLLC_RS28950	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS28980	COG0601	transmembrane transport
SLLC_RS28985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS28990	COG0444	Belongs to the ABC transporter superfamily
SLLC_RS28995	COG4608	Belongs to the ABC transporter superfamily
SLLC_RS29010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SLLC_RS29020	COG4585	Histidine kinase
SLLC_RS29025	COG2197	response regulator
SLLC_RS29030	COG2318	DinB family
SLLC_RS29050	COG4166	transmembrane transport
SLLC_RS29055	COG0601	transmembrane transport
SLLC_RS29060	COG4171	peptide transport system, permease
SLLC_RS29070	COG0586	Pfam SNARE associated Golgi protein
SLLC_RS29110	COG0298	carbon dioxide binding
SLLC_RS29120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SLLC_RS29125	COG0375	protein maturation
SLLC_RS29165	COG1024	Enoyl-CoA hydratase
SLLC_RS29165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SLLC_RS29225	COG3290	protein histidine kinase activity
SLLC_RS29240	COG0514	ATP-dependent DNA helicase (RecQ)
SLLC_RS29245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS29250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS29255	COG1126	abc transporter atp-binding protein
SLLC_RS29260	COG0765	amino acid transport
SLLC_RS29265	COG0765	amino acid transport
SLLC_RS29275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS29280	COG1126	abc transporter atp-binding protein
SLLC_RS29305	COG2326	polyphosphate kinase activity
SLLC_RS29315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SLLC_RS29350	COG2957	Belongs to the agmatine deiminase family
SLLC_RS29355	COG0747	negative chemotaxis
SLLC_RS29365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SLLC_RS29375	COG4608	Belongs to the ABC transporter superfamily
SLLC_RS29385	COG2957	Belongs to the agmatine deiminase family
SLLC_RS29450	COG2890	protein-(glutamine-N5) methyltransferase activity
SLLC_RS29480	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SLLC_RS29485	COG0483	inositol monophosphate 1-phosphatase activity
SLLC_RS29525	COG1012	belongs to the aldehyde dehydrogenase family
SLLC_RS29540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
SLLC_RS29600	COG2018	Roadblock/LC7 domain
SLLC_RS29610	COG3012	SEC-C Motif Domain Protein
SLLC_RS29615	COG1946	Acyl-CoA thioesterase
SLLC_RS29630	COG1132	(ABC) transporter
SLLC_RS29635	COG1132	(ABC) transporter
SLLC_RS29640	COG0277	FAD linked oxidase domain protein
SLLC_RS29660	COG2072	flavoprotein involved in K transport
SLLC_RS29675	COG1116	anion transmembrane transporter activity
SLLC_RS29680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SLLC_RS29695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLLC_RS29710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
SLLC_RS29720	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SLLC_RS29725	COG0702	epimerase
SLLC_RS29740	COG1595	DNA-templated transcription, initiation
SLLC_RS29750	COG0406	alpha-ribazole phosphatase activity
SLLC_RS29805	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
SLLC_RS29810	COG2706	6-phosphogluconolactonase activity
SLLC_RS29820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SLLC_RS29830	COG1902	pentaerythritol trinitrate reductase activity
SLLC_RS29835	COG0640	Transcriptional regulator
SLLC_RS29840	COG0493	'glutamate synthase
SLLC_RS29855	COG1309	transcriptional regulator
SLLC_RS29860	COG4221	oxidoreductase activity
SLLC_RS29880	COG0584	glycerophosphoryl diester phosphodiesterase
SLLC_RS29890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS29940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
SLLC_RS29955	COG0494	nUDIX hydrolase
SLLC_RS29960	COG0477	Major facilitator Superfamily
SLLC_RS29965	COG4106	trans-aconitate 2-methyltransferase activity
SLLC_RS29975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SLLC_RS30010	COG0583	DNA-binding transcription factor activity
SLLC_RS30040	COG1940	carbohydrate kinase activity
SLLC_RS30065	COG0464	growth
SLLC_RS30090	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SLLC_RS30125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SLLC_RS30155	COG1716	ATPase activity
SLLC_RS30155	COG0842	Transport permease protein
SLLC_RS30155	COG1131	(ABC) transporter
SLLC_RS30195	COG0725	ABC transporter, periplasmic molybdate-binding protein
SLLC_RS30200	COG3585	molybdate ion transport
SLLC_RS30215	COG1461	Dihydroxyacetone kinase
SLLC_RS30220	COG2376	Dihydroxyacetone kinase
SLLC_RS30235	COG2124	cytochrome p450
SLLC_RS30270	COG2259	Doxx family
SLLC_RS30275	COG3387	PFAM Glycoside hydrolase 15-related
SLLC_RS30300	COG1063	alcohol dehydrogenase
SLLC_RS30305	COG0156	8-amino-7-oxononanoate synthase activity
SLLC_RS30315	COG1349	DNA-binding transcription factor activity
SLLC_RS30335	COG1063	alcohol dehydrogenase
SLLC_RS30350	COG0515	serine threonine protein kinase
SLLC_RS30355	COG1960	acyl-CoA dehydrogenase activity
SLLC_RS30425	COG2304	oxidoreductase activity
SLLC_RS30435	COG1113	amino acid transport
SLLC_RS30455	COG0515	serine threonine protein kinase
SLLC_RS30455	COG2815	serine threonine protein kinase
SLLC_RS30490	COG2070	2-Nitropropane dioxygenase
SLLC_RS30500	COG0387	Pfam Sodium calcium exchanger
SLLC_RS30525	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS30545	COG0596	Alpha beta hydrolase
SLLC_RS30625	COG1053	succinate dehydrogenase
SLLC_RS30650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SLLC_RS30650	COG2010	Cytochrome c
SLLC_RS30655	COG2080	2 iron, 2 sulfur cluster binding
SLLC_RS30665	COG0531	amino acid
SLLC_RS30675	COG0501	Belongs to the peptidase M48B family
SLLC_RS30700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SLLC_RS30710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SLLC_RS30745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLLC_RS30770	COG0789	Transcriptional regulator
SLLC_RS30805	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS30865	COG0513	Belongs to the DEAD box helicase family
SLLC_RS30870	COG1846	Transcriptional regulator
SLLC_RS30880	COG1278	Cold shock
SLLC_RS30890	COG2124	cytochrome p450
SLLC_RS30925	COG4941	Belongs to the sigma-70 factor family
SLLC_RS30935	COG1136	(ABC) transporter
SLLC_RS30950	COG4591	ABC-type transport system involved in lipoprotein release permease component
SLLC_RS30950	COG1136	(ABC) transporter
SLLC_RS30960	COG2319	Wd-40 repeat
SLLC_RS30960	COG4249	Peptidase C14 caspase catalytic subunit p20
SLLC_RS30970	COG0583	DNA-binding transcription factor activity
SLLC_RS30975	COG2188	Transcriptional regulator
SLLC_RS30995	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SLLC_RS31000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLLC_RS31010	COG2188	Transcriptional regulator
SLLC_RS31020	COG2175	clavaminate synthase activity
SLLC_RS31035	COG1063	alcohol dehydrogenase
SLLC_RS31110	COG1404	Belongs to the peptidase S8 family
SLLC_RS31160	COG0714	Associated with various cellular activities
SLLC_RS31180	COG1846	Transcriptional regulator
SLLC_RS31185	COG1846	Transcriptional regulator
SLLC_RS31190	COG1764	response to oxidative stress
SLLC_RS31205	COG2197	response regulator
SLLC_RS31245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SLLC_RS31280	COG0697	spore germination
SLLC_RS31365	COG1686	Belongs to the peptidase S11 family
SLLC_RS31370	COG1725	Transcriptional regulator
SLLC_RS31375	COG1131	(ABC) transporter
SLLC_RS31395	COG0477	Major facilitator Superfamily
SLLC_RS31415	COG0667	Aldo Keto reductase
SLLC_RS31420	COG1505	serine-type exopeptidase activity
SLLC_RS31445	COG0583	DNA-binding transcription factor activity
SLLC_RS31450	COG3511	phospholipase C
SLLC_RS31465	COG4585	Histidine kinase
SLLC_RS31470	COG2197	response regulator
SLLC_RS31480	COG2135	peptidase activity
SLLC_RS31495	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SLLC_RS31500	COG2264	protein methyltransferase activity
SLLC_RS31510	COG2011	ABC-type metal ion transport system permease component
SLLC_RS31515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SLLC_RS31520	COG1464	Belongs to the NlpA lipoprotein family
SLLC_RS31535	COG1131	(ABC) transporter
SLLC_RS31570	COG0583	DNA-binding transcription factor activity
SLLC_RS31575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SLLC_RS31585	COG1113	amino acid transport
SLLC_RS31620	COG2890	protein-(glutamine-N5) methyltransferase activity
SLLC_RS31675	COG1252	NADH dehydrogenase
SLLC_RS31695	COG0009	L-threonylcarbamoyladenylate synthase
SLLC_RS31725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SLLC_RS31750	COG2070	2-Nitropropane dioxygenase
SLLC_RS31770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SLLC_RS31785	COG1940	carbohydrate kinase activity
SLLC_RS31790	COG1063	alcohol dehydrogenase
SLLC_RS31805	COG0501	Belongs to the peptidase M48B family
SLLC_RS31810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SLLC_RS31810	COG1796	DNA polymerase
SLLC_RS31860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
SLLC_RS31865	COG1509	lysine 2,3-aminomutase activity
SLLC_RS31875	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SLLC_RS31885	COG0488	(ABC) transporter
SLLC_RS31890	COG3387	PFAM Glycoside hydrolase 15-related
SLLC_RS31910	COG2239	Acts as a magnesium transporter
SLLC_RS31915	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
SLLC_RS31920	COG2205	protein histidine kinase activity
SLLC_RS31925	COG0745	RESPONSE REGULATOR receiver
SLLC_RS31930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SLLC_RS31945	COG0574	Belongs to the PEP-utilizing enzyme family
SLLC_RS31945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SLLC_RS31970	COG1024	Enoyl-CoA hydratase
SLLC_RS31995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
SLLC_RS32035	COG0318	PFAM AMP-dependent synthetase and ligase
SLLC_RS32050	COG1136	(ABC) transporter
SLLC_RS32050	COG0577	efflux transmembrane transporter activity
SLLC_RS32070	COG2957	Belongs to the agmatine deiminase family
SLLC_RS32095	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
SLLC_RS32115	COG2017	converts alpha-aldose to the beta-anomer
SLLC_RS32130	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS32135	COG1271	oxidase subunit
SLLC_RS32155	COG3387	PFAM Glycoside hydrolase 15-related
SLLC_RS32185	COG0501	Belongs to the peptidase M48B family
SLLC_RS32190	COG1968	undecaprenyl-diphosphatase activity
SLLC_RS32220	COG0516	GMP reductase activity
SLLC_RS32220	COG0517	IMP dehydrogenase activity
SLLC_RS32225	COG1902	pentaerythritol trinitrate reductase activity
SLLC_RS32240	COG1024	Enoyl-CoA hydratase
SLLC_RS32255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLLC_RS32265	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SLLC_RS32295	COG2409	Drug exporters of the RND superfamily
SLLC_RS32300	COG5002	protein histidine kinase activity
SLLC_RS32305	COG0745	RESPONSE REGULATOR receiver
SLLC_RS32315	COG1172	Belongs to the binding-protein-dependent transport system permease family
SLLC_RS32320	COG1129	ABC transporter
SLLC_RS32325	COG3284	Transcriptional regulator
SLLC_RS32345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SLLC_RS32355	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS32385	COG2345	Transcriptional regulator
SLLC_RS32390	COG0110	maltose O-acetyltransferase activity
SLLC_RS32395	COG0366	Alpha amylase catalytic
SLLC_RS32480	COG0464	growth
SLLC_RS32525	COG3386	PFAM SMP-30 Gluconolaconase
SLLC_RS32535	COG0546	phosphoglycolate phosphatase activity
SLLC_RS32540	COG2824	Alkylphosphonate utilization operon protein PhnA
SLLC_RS32595	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS32605	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SLLC_RS32640	COG4989	oxidoreductase activity
SLLC_RS32665	COG2353	YceI-like domain
SLLC_RS32670	COG0656	L-ascorbic acid biosynthetic process
SLLC_RS32720	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS32725	COG1957	nucleoside hydrolase
SLLC_RS32745	COG4221	oxidoreductase activity
SLLC_RS32790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SLLC_RS32795	COG0765	amino acid transport
SLLC_RS32800	COG1126	abc transporter atp-binding protein
SLLC_RS32825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SLLC_RS32830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SLLC_RS32885	COG0154	amidase activity
SLLC_RS32935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SLLC_RS32945	COG0154	amidase activity
SLLC_RS32960	COG1278	Cold shock
SLLC_RS32980	COG2205	protein histidine kinase activity
SLLC_RS32985	COG0745	RESPONSE REGULATOR receiver
SLLC_RS33070	COG0577	efflux transmembrane transporter activity
SLLC_RS33070	COG1136	(ABC) transporter
SLLC_RS33075	COG2205	protein histidine kinase activity
SLLC_RS33080	COG0745	RESPONSE REGULATOR receiver
SLLC_RS33100	COG4977	sequence-specific DNA binding
SLLC_RS33130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SLLC_RS33170	COG0477	Major facilitator Superfamily
SLLC_RS33200	COG2226	methyltransferase
SLLC_RS33210	COG2318	DinB family
SLLC_RS33240	COG0438	transferase activity, transferring glycosyl groups
SLLC_RS33250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SLLC_RS33255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SLLC_RS33275	COG1309	transcriptional regulator
SLLC_RS33280	COG0488	(ABC) transporter
SLLC_RS33295	COG0402	S-adenosylhomocysteine deaminase activity
SLLC_RS33310	COG0492	ferredoxin-NADP+ reductase activity
SLLC_RS33385	COG1595	DNA-templated transcription, initiation
SLLC_RS33425	COG2130	NADP-dependent
SLLC_RS33465	COG1819	glycosyl
SLLC_RS33535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SLLC_RS33545	COG2197	response regulator
SLLC_RS33545	COG3903	Transcriptional regulator
SLLC_RS33560	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
SLLC_RS33575	COG2409	Drug exporters of the RND superfamily
SLLC_RS33590	COG0038	chloride channel
SLLC_RS33600	COG0431	NADPH-dependent FMN reductase
SLLC_RS33610	COG0492	ferredoxin-NADP+ reductase activity
SLLC_RS33610	COG3118	belongs to the thioredoxin family
SLLC_RS33645	COG2124	cytochrome p450
SLLC_RS33700	COG2945	thiolester hydrolase activity
SLLC_RS33700	COG0596	Alpha beta hydrolase
SLLC_RS33720	COG3291	Pkd domain containing protein
SLLC_RS33790	COG4221	oxidoreductase activity
SLLC_RS33825	COG2197	response regulator
SLLC_RS33845	COG2378	regulation of single-species biofilm formation
SLLC_RS33865	COG0789	Transcriptional regulator
SLLC_RS33870	COG1819	glycosyl
SLLC_RS33880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SLLC_RS33905	COG0640	Transcriptional regulator
SLLC_RS33960	COG0583	DNA-binding transcription factor activity
SLLC_RS34020	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS34050	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SLLC_RS34075	COG1309	transcriptional regulator
SLLC_RS34080	COG0604	alcohol dehydrogenase
SLLC_RS34130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SLLC_RS34140	COG0254	rRNA binding
SLLC_RS34145	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SLLC_RS34150	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SLLC_RS34175	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
SLLC_RS34195	COG3655	Transcriptional regulator
SLLC_RS34205	COG2267	carboxylic ester hydrolase activity
SLLC_RS34275	COG1428	Deoxynucleoside kinase
SLLC_RS34370	COG1619	proteins homologs of microcin C7 resistance protein MccF
SLLC_RS34395	COG0671	phosphoesterase, PA-phosphatase related
SLLC_RS34435	COG2814	Major facilitator Superfamily
SLLC_RS34470	COG2267	carboxylic ester hydrolase activity
SLLC_RS34510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SLLC_RS34660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SLLC_RS34700	COG1309	transcriptional regulator
SLLC_RS34750	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS34770	COG0681	Belongs to the peptidase S26 family
SLLC_RS34795	COG2188	Transcriptional regulator
SLLC_RS34825	COG0662	Cupin 2, conserved barrel domain protein
SLLC_RS34860	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SLLC_RS34870	COG1132	(ABC) transporter
SLLC_RS34875	COG1132	(ABC) transporter
SLLC_RS34895	COG1509	lysine 2,3-aminomutase activity
SLLC_RS34920	COG0673	inositol 2-dehydrogenase activity
SLLC_RS34925	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SLLC_RS34930	COG1181	Belongs to the D-alanine--D-alanine ligase family
SLLC_RS34950	COG3173	Aminoglycoside phosphotransferase
SLLC_RS34990	COG0531	amino acid
SLLC_RS35030	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SLLC_RS35145	COG0702	epimerase
SLLC_RS35155	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SLLC_RS35170	COG0784	Response regulator, receiver
SLLC_RS35175	COG4251	negative regulation of phosphorylation
SLLC_RS35195	COG1846	Transcriptional regulator
SLLC_RS35200	COG0671	phosphoesterase, PA-phosphatase related
SLLC_RS35335	COG0667	Aldo Keto reductase
SLLC_RS35375	COG2249	NAD(P)H dehydrogenase (quinone) activity
SLLC_RS35380	COG1132	(ABC) transporter
SLLC_RS35385	COG3629	intracellular signal transduction
SLLC_RS35455	COG2233	PERMEase
SLLC_RS35490	COG0326	Molecular chaperone. Has ATPase activity
SLLC_RS35505	COG3751	2OG-Fe(II) oxygenase superfamily
SLLC_RS35555	COG3903	Transcriptional regulator
SLLC_RS35555	COG3629	intracellular signal transduction
SLLC_RS35615	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
SLLC_RS35620	COG0587	DNA-directed DNA polymerase activity
SLLC_RS35625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SLLC_RS35685	COG3237	CsbD-like
SLLC_RS35750	COG0071	Belongs to the small heat shock protein (HSP20) family
SLLC_RS35765	COG1028	Short-chain dehydrogenase reductase Sdr
SLLC_RS35780	COG1335	isochorismatase
SLLC_RS35790	COG2124	cytochrome p450
SLLC_RS35805	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
SLLC_RS35830	COG3293	Transposase