locus-tag	class	description
T261_RS00055	COG0367	asparagine synthase
T261_RS00060	COG2867	negative regulation of translational initiation
T261_RS00060	COG2226	methyltransferase
T261_RS00065	COG1819	glycosyl
T261_RS00085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS00090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS00100	COG2867	negative regulation of translational initiation
T261_RS00110	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS00125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
T261_RS00125	COG0825	malonyl-CoA metabolic process
T261_RS00130	COG0511	ligase activity, forming carbon-carbon bonds
T261_RS00135	COG0439	Biotin carboxylase
T261_RS00140	COG3629	intracellular signal transduction
T261_RS00140	COG3903	Transcriptional regulator
T261_RS00150	COG0477	Major facilitator Superfamily
T261_RS00155	COG1309	transcriptional regulator
T261_RS00165	COG2084	Dehydrogenase
T261_RS00175	COG3104	oligopeptide transport
T261_RS00180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS00185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS00190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS00200	COG2345	Transcriptional regulator
T261_RS00210	COG2345	Transcriptional regulator
T261_RS00435	COG1335	isochorismatase
T261_RS00460	COG1902	pentaerythritol trinitrate reductase activity
T261_RS00480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
T261_RS00575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
T261_RS00580	COG3408	Glycogen debranching enzyme
T261_RS00580	COG3119	arylsulfatase activity
T261_RS00600	COG0431	NADPH-dependent FMN reductase
T261_RS00645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T261_RS00650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS00720	COG0702	epimerase
T261_RS00735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
T261_RS00745	COG1794	racemase activity, acting on amino acids and derivatives
T261_RS00755	COG3293	Transposase
T261_RS00790	COG3469	chitinase activity
T261_RS00810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
T261_RS00840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
T261_RS00855	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
T261_RS00875	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
T261_RS00875	COG0515	serine threonine protein kinase
T261_RS00895	COG2186	Transcriptional regulator
T261_RS00900	COG1113	amino acid transport
T261_RS00915	COG0583	DNA-binding transcription factor activity
T261_RS00920	COG3291	Pkd domain containing protein
T261_RS00995	COG2755	lipolytic protein G-D-S-L family
T261_RS01035	COG1078	dGTPase activity
T261_RS01040	COG0243	molybdopterin cofactor binding
T261_RS01050	COG2255	four-way junction helicase activity
T261_RS01060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
T261_RS01080	COG2070	2-Nitropropane dioxygenase
T261_RS01080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
T261_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS01085	COG3321	synthase
T261_RS01085	COG4221	oxidoreductase activity
T261_RS01085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS01090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
T261_RS01090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS01090	COG3321	synthase
T261_RS01095	COG4221	oxidoreductase activity
T261_RS01095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS01095	COG0300	oxidoreductase activity
T261_RS01095	COG3321	synthase
T261_RS01100	COG0367	asparagine synthase
T261_RS01115	COG3629	intracellular signal transduction
T261_RS01115	COG3903	Transcriptional regulator
T261_RS01135	COG2249	NAD(P)H dehydrogenase (quinone) activity
T261_RS01150	COG0604	alcohol dehydrogenase
T261_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS01150	COG3321	synthase
T261_RS01155	COG3973	AAA domain
T261_RS01190	COG0515	serine threonine protein kinase
T261_RS01255	COG0789	Transcriptional regulator
T261_RS01290	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS01310	COG0412	Dienelactone hydrolase
T261_RS01360	COG0539	negative regulation of cytoplasmic translation
T261_RS01390	COG0189	ligase activity
T261_RS01390	COG4067	protein conserved in archaea
T261_RS01395	COG2814	Major facilitator Superfamily
T261_RS01455	COG0702	epimerase
T261_RS01545	COG0628	permease
T261_RS01555	COG1573	uracil-dna glycosylase
T261_RS01575	COG2249	NAD(P)H dehydrogenase (quinone) activity
T261_RS01585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T261_RS01590	COG3170	Tfp pilus assembly protein FimV
T261_RS01595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
T261_RS01625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T261_RS01630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS01705	COG2318	DinB family
T261_RS01740	COG0477	Major facilitator Superfamily
T261_RS01760	COG0142	geranyltranstransferase activity
T261_RS01800	COG2226	methyltransferase
T261_RS01820	COG0456	acetyltransferase
T261_RS01835	COG0010	Belongs to the arginase family
T261_RS01885	COG3387	PFAM Glycoside hydrolase 15-related
T261_RS01910	COG1733	regulation of RNA biosynthetic process
T261_RS01970	COG2188	Transcriptional regulator
T261_RS01980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
T261_RS01985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
T261_RS01995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
T261_RS02030	COG2318	DinB family
T261_RS02055	COG1141	Ferredoxin
T261_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS02090	COG0183	Belongs to the thiolase family
T261_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS02100	COG1960	acyl-CoA dehydrogenase activity
T261_RS02130	COG3290	protein histidine kinase activity
T261_RS02155	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS02170	COG1793	dna ligase
T261_RS02185	COG0531	amino acid
T261_RS02205	COG0309	Hydrogenase expression formation protein (HypE)
T261_RS02215	COG0298	carbon dioxide binding
T261_RS02220	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
T261_RS02225	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
T261_RS02230	COG0375	protein maturation
T261_RS02235	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
T261_RS02260	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
T261_RS02275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
T261_RS02290	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS02310	COG2084	Dehydrogenase
T261_RS02315	COG3622	Belongs to the hyi family
T261_RS02320	COG3960	tartronate-semialdehyde synthase activity
T261_RS02340	COG1960	acyl-CoA dehydrogenase activity
T261_RS02350	COG0242	peptide deformylase activity
T261_RS02360	COG3442	glutamine amidotransferase
T261_RS02365	COG0205	6-phosphofructokinase activity
T261_RS02425	COG0829	nickel cation binding
T261_RS02430	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
T261_RS02435	COG0830	nickel cation binding
T261_RS02440	COG0804	urea catabolic process
T261_RS02445	COG0832	Belongs to the urease beta subunit family
T261_RS02450	COG0831	urea catabolic process
T261_RS02480	COG2801	Transposase and inactivated derivatives
T261_RS02500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
T261_RS02540	COG0740	serine-type endopeptidase activity
T261_RS02565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
T261_RS02570	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
T261_RS02575	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
T261_RS02600	COG0456	acetyltransferase
T261_RS02630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
T261_RS02635	COG3663	DNA glycosylase
T261_RS02645	COG1940	carbohydrate kinase activity
T261_RS02650	COG2188	Transcriptional regulator
T261_RS02660	COG1595	DNA-templated transcription, initiation
T261_RS02665	COG2267	carboxylic ester hydrolase activity
T261_RS02695	COG1522	sequence-specific DNA binding
T261_RS02700	COG0419	ATPase involved in DNA repair
T261_RS02705	COG0420	3'-5' exonuclease activity
T261_RS02710	COG1739	Uncharacterized protein family UPF0029
T261_RS02770	COG1832	CoA-binding protein
T261_RS02835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
T261_RS02840	COG1968	undecaprenyl-diphosphatase activity
T261_RS02935	COG1764	response to oxidative stress
T261_RS02940	COG1846	Transcriptional regulator
T261_RS02950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS02990	COG0739	heme binding
T261_RS03000	COG1609	Transcriptional regulator
T261_RS03010	COG1175	transmembrane transport
T261_RS03015	COG0395	ABC-type sugar transport system, permease component
T261_RS03040	COG1278	Cold shock
T261_RS03045	COG2356	endonuclease I
T261_RS03055	COG3285	dna ligase
T261_RS03055	COG1793	dna ligase
T261_RS03060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
T261_RS03070	COG3012	SEC-C Motif Domain Protein
T261_RS03100	COG2270	Major facilitator Superfamily
T261_RS03110	COG3030	protein affecting phage T7 exclusion by the F plasmid
T261_RS03115	COG0463	Glycosyl transferase, family 2
T261_RS03125	COG1228	amidohydrolase
T261_RS03150	COG1960	acyl-CoA dehydrogenase activity
T261_RS03160	COG1309	transcriptional regulator
T261_RS03180	COG1917	Cupin 2, conserved barrel domain protein
T261_RS03185	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS03195	COG0488	(ABC) transporter
T261_RS03200	COG2764	glyoxalase bleomycin resistance protein dioxygenase
T261_RS03210	COG1595	DNA-templated transcription, initiation
T261_RS03220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS03230	COG2409	Drug exporters of the RND superfamily
T261_RS03245	COG0076	glutamate decarboxylase activity
T261_RS03260	COG2030	dehydratase
T261_RS03285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS03310	COG0477	Major facilitator Superfamily
T261_RS03320	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS03325	COG0657	acetylesterase activity
T261_RS03375	COG1309	transcriptional regulator
T261_RS03450	COG2175	clavaminate synthase activity
T261_RS03495	COG0242	peptide deformylase activity
T261_RS03500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
T261_RS03510	COG0602	queuosine metabolic process
T261_RS03535	COG0302	gtp cyclohydrolase
T261_RS03575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
T261_RS03580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS03585	COG0179	Fumarylacetoacetate (FAA) hydrolase
T261_RS03610	COG0477	Major facilitator Superfamily
T261_RS03625	COG0753	catalase activity
T261_RS03775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
T261_RS04110	COG0477	Major facilitator Superfamily
T261_RS04120	COG2318	DinB family
T261_RS04130	COG4166	transmembrane transport
T261_RS04215	COG3293	Transposase
T261_RS04265	COG1302	Protein conserved in bacteria
T261_RS04275	COG3239	Fatty acid desaturase
T261_RS04295	COG1295	ribonuclease BN
T261_RS04315	COG0009	L-threonylcarbamoyladenylate synthase
T261_RS04350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
T261_RS04360	COG0254	rRNA binding
T261_RS04365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T261_RS04370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
T261_RS04375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
T261_RS04390	COG1121	(ABC) transporter
T261_RS04395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T261_RS04410	COG0523	cobalamin synthesis protein
T261_RS04435	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T261_RS04455	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
T261_RS04490	COG1902	pentaerythritol trinitrate reductase activity
T261_RS04495	COG1902	pentaerythritol trinitrate reductase activity
T261_RS04505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
T261_RS04515	COG2971	BadF BadG BcrA BcrD
T261_RS04530	COG2706	6-phosphogluconolactonase activity
T261_RS04580	COG2124	cytochrome p450
T261_RS04615	COG4221	oxidoreductase activity
T261_RS04620	COG4213	ABC transporter substrate-binding protein
T261_RS04635	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
T261_RS04645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
T261_RS04670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS04675	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
T261_RS04680	COG2080	2 iron, 2 sulfur cluster binding
T261_RS04690	COG1796	DNA polymerase
T261_RS04690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
T261_RS04715	COG1131	(ABC) transporter
T261_RS04785	COG2072	flavoprotein involved in K transport
T261_RS04800	COG2018	Roadblock/LC7 domain
T261_RS04805	COG5002	protein histidine kinase activity
T261_RS04815	COG0477	Major facilitator Superfamily
T261_RS04820	COG0247	lactate metabolic process
T261_RS04825	COG1139	Iron-sulfur cluster binding protein
T261_RS04830	COG1556	Lactate utilization protein
T261_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS04855	COG1132	(ABC) transporter
T261_RS04885	COG1132	(ABC) transporter
T261_RS04890	COG1132	(ABC) transporter
T261_RS04915	COG1946	Acyl-CoA thioesterase
T261_RS04925	COG2018	Roadblock/LC7 domain
T261_RS04975	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T261_RS04995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T261_RS05000	COG0765	amino acid transport
T261_RS05005	COG1126	abc transporter atp-binding protein
T261_RS05020	COG3458	cephalosporin-C deacetylase activity
T261_RS05040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T261_RS05045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T261_RS05045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T261_RS05050	COG3023	N-Acetylmuramoyl-L-alanine amidase
T261_RS05065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
T261_RS05065	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
T261_RS05080	COG3511	phospholipase C
T261_RS05090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T261_RS05095	COG0588	phosphoglycerate mutase activity
T261_RS05100	COG1070	Carbohydrate kinase
T261_RS05110	COG2814	Major facilitator Superfamily
T261_RS05115	COG1349	DNA-binding transcription factor activity
T261_RS05155	COG1960	acyl-CoA dehydrogenase activity
T261_RS05160	COG1960	acyl-CoA dehydrogenase activity
T261_RS05190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T261_RS05215	COG3572	ergothioneine biosynthetic process
T261_RS05220	COG1262	PFAM Formylglycine-generating sulfatase enzyme
T261_RS05230	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
T261_RS05255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS05275	COG3360	Dodecin
T261_RS05280	COG0531	amino acid
T261_RS05290	COG3537	Alpha-1,2-mannosidase
T261_RS05365	COG2706	6-phosphogluconolactonase activity
T261_RS05375	COG1652	LysM domain
T261_RS05385	COG1960	acyl-CoA dehydrogenase activity
T261_RS05390	COG1024	Enoyl-CoA hydratase
T261_RS05420	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS05430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T261_RS05440	COG0747	negative chemotaxis
T261_RS05445	COG1940	carbohydrate kinase activity
T261_RS05455	COG1278	Cold shock
T261_RS05485	COG3246	L-lysine catabolic process to acetate
T261_RS05490	COG1250	3-hydroxyacyl-CoA dehydrogenase
T261_RS05525	COG1686	Belongs to the peptidase S11 family
T261_RS05530	COG2124	cytochrome p450
T261_RS05555	COG4715	Zinc finger, swim domain protein
T261_RS05560	COG3552	Protein containing von Willebrand factor type A (VWA) domain
T261_RS05565	COG2425	protein containing a von Willebrand factor type A (vWA) domain
T261_RS05570	COG0714	Associated with various cellular activities
T261_RS05575	COG3831	ATPase activity
T261_RS05590	COG3959	Transketolase, thiamine diphosphate binding domain
T261_RS05595	COG3958	Transketolase
T261_RS05600	COG2267	carboxylic ester hydrolase activity
T261_RS05610	COG1960	acyl-CoA dehydrogenase activity
T261_RS05630	COG2018	Roadblock/LC7 domain
T261_RS05680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS05725	COG2755	lipolytic protein G-D-S-L family
T261_RS05730	COG2365	Tyrosine phosphatase family
T261_RS05745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
T261_RS05760	COG1657	PFAM Prenyltransferase squalene oxidase
T261_RS05770	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
T261_RS05780	COG1562	ergosterol biosynthetic process
T261_RS05785	COG1134	teichoic acid transport
T261_RS05820	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
T261_RS05825	COG3920	Histidine kinase
T261_RS05850	COG4977	sequence-specific DNA binding
T261_RS05860	COG2183	response to ionizing radiation
T261_RS05890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
T261_RS05900	COG2936	dipeptidyl-peptidase activity
T261_RS05915	COG3568	Endonuclease Exonuclease Phosphatase
T261_RS05920	COG2197	response regulator
T261_RS05940	COG1113	amino acid transport
T261_RS05955	COG1250	3-hydroxyacyl-CoA dehydrogenase
T261_RS05955	COG1024	Enoyl-CoA hydratase
T261_RS05960	COG0183	Belongs to the thiolase family
T261_RS05965	COG1960	acyl-CoA dehydrogenase activity
T261_RS05970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS05975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
T261_RS05990	COG3268	Saccharopine dehydrogenase
T261_RS05995	COG1515	deoxyribonuclease V activity
T261_RS06010	COG2814	Major facilitator Superfamily
T261_RS06015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T261_RS06025	COG1349	DNA-binding transcription factor activity
T261_RS06035	COG1309	transcriptional regulator
T261_RS06070	COG3226	Transcriptional regulator
T261_RS06090	COG2197	response regulator
T261_RS06105	COG0745	RESPONSE REGULATOR receiver
T261_RS06110	COG2205	protein histidine kinase activity
T261_RS06180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
T261_RS06200	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS06225	COG4585	Histidine kinase
T261_RS06230	COG2197	response regulator
T261_RS06260	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
T261_RS06330	COG2264	protein methyltransferase activity
T261_RS06395	COG3958	Transketolase
T261_RS06400	COG3959	Transketolase, thiamine diphosphate binding domain
T261_RS06410	COG2755	lipolytic protein G-D-S-L family
T261_RS06440	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS06465	COG3511	phospholipase C
T261_RS06485	COG0789	Transcriptional regulator
T261_RS06525	COG0477	Major facilitator Superfamily
T261_RS06530	COG0583	DNA-binding transcription factor activity
T261_RS06535	COG1733	regulation of RNA biosynthetic process
T261_RS06555	COG0477	Major facilitator Superfamily
T261_RS06590	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
T261_RS06605	COG3629	intracellular signal transduction
T261_RS06605	COG3903	Transcriptional regulator
T261_RS06635	COG3340	Belongs to the peptidase S51 family
T261_RS06685	COG1595	DNA-templated transcription, initiation
T261_RS06715	COG3396	Phenylacetate-CoA oxygenase
T261_RS06760	COG1063	alcohol dehydrogenase
T261_RS06765	COG1349	DNA-binding transcription factor activity
T261_RS06795	COG0789	Transcriptional regulator
T261_RS06805	COG1136	(ABC) transporter
T261_RS06805	COG0577	efflux transmembrane transporter activity
T261_RS06810	COG1136	(ABC) transporter
T261_RS06810	COG0577	efflux transmembrane transporter activity
T261_RS06815	COG2197	response regulator
T261_RS06820	COG4585	Histidine kinase
T261_RS06830	COG2207	Transcriptional regulator
T261_RS06835	COG2318	DinB family
T261_RS06850	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
T261_RS06860	COG0583	DNA-binding transcription factor activity
T261_RS06870	COG3467	pyridoxamine 5'-phosphate
T261_RS06900	COG0477	Major facilitator Superfamily
T261_RS06905	COG0745	RESPONSE REGULATOR receiver
T261_RS06910	COG2205	protein histidine kinase activity
T261_RS06945	COG0477	Major facilitator Superfamily
T261_RS07005	COG1309	transcriptional regulator
T261_RS07010	COG3293	Transposase
T261_RS07075	COG2814	Major facilitator Superfamily
T261_RS07100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
T261_RS07105	COG1396	sequence-specific DNA binding
T261_RS07110	COG2186	Transcriptional regulator
T261_RS07115	COG2223	nitrite transmembrane transporter activity
T261_RS07120	COG1846	Transcriptional regulator
T261_RS07120	COG0456	acetyltransferase
T261_RS07130	COG3655	Transcriptional regulator
T261_RS07170	COG2267	carboxylic ester hydrolase activity
T261_RS07185	COG1335	isochorismatase
T261_RS07230	COG1472	Belongs to the glycosyl hydrolase 3 family
T261_RS07300	COG3594	Acyltransferase
T261_RS07310	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T261_RS07320	COG0829	nickel cation binding
T261_RS07325	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
T261_RS07330	COG0830	nickel cation binding
T261_RS07335	COG0804	urea catabolic process
T261_RS07340	COG0832	Belongs to the urease beta subunit family
T261_RS07340	COG0831	urea catabolic process
T261_RS07345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
T261_RS07400	COG3629	intracellular signal transduction
T261_RS07400	COG3903	Transcriptional regulator
T261_RS07425	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
T261_RS07445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
T261_RS07540	COG1595	DNA-templated transcription, initiation
T261_RS07555	COG1595	DNA-templated transcription, initiation
T261_RS07680	COG3209	COG3209 Rhs family protein
T261_RS07705	COG3226	Transcriptional regulator
T261_RS07720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS07760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS07775	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS07785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
T261_RS07795	COG1605	Chorismate mutase
T261_RS07795	COG0287	Prephenate dehydrogenase
T261_RS07805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS07810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
T261_RS07835	COG0583	DNA-binding transcription factor activity
T261_RS07850	COG0656	L-ascorbic acid biosynthetic process
T261_RS07865	COG2226	methyltransferase
T261_RS07880	COG2154	pterin-4-alpha-carbinolamine dehydratase
T261_RS07900	COG0531	amino acid
T261_RS07915	COG3424	synthase
T261_RS07925	COG0671	phosphoesterase, PA-phosphatase related
T261_RS07930	COG2226	methyltransferase
T261_RS07965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
T261_RS07980	COG2124	cytochrome p450
T261_RS07995	COG1619	proteins homologs of microcin C7 resistance protein MccF
T261_RS08000	COG4946	Tricorn protease homolog
T261_RS08000	COG0823	Involved in the tonB-independent uptake of proteins
T261_RS08000	COG1506	peptidase
T261_RS08005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T261_RS08010	COG2362	D-Aminopeptidase
T261_RS08020	COG1136	(ABC) transporter
T261_RS08030	COG1653	transport
T261_RS08035	COG0366	Alpha amylase catalytic
T261_RS08040	COG1653	transport
T261_RS08045	COG1175	transmembrane transport
T261_RS08050	COG0395	ABC-type sugar transport system, permease component
T261_RS08110	COG1131	(ABC) transporter
T261_RS08165	COG2186	Transcriptional regulator
T261_RS08175	COG2814	Major facilitator Superfamily
T261_RS08195	COG1250	3-hydroxyacyl-CoA dehydrogenase
T261_RS08210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS08210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS08215	COG2301	Belongs to the HpcH HpaI aldolase family
T261_RS08225	COG1960	acyl-CoA dehydrogenase activity
T261_RS08230	COG0688	phosphatidylethanolamine metabolic process
T261_RS08240	COG1929	Belongs to the glycerate kinase type-1 family
T261_RS08285	COG2267	carboxylic ester hydrolase activity
T261_RS08335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
T261_RS08340	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS08360	COG1136	(ABC) transporter
T261_RS08360	COG0577	efflux transmembrane transporter activity
T261_RS08370	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
T261_RS08380	COG0483	inositol monophosphate 1-phosphatase activity
T261_RS08395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
T261_RS08420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
T261_RS08430	COG1607	acyl-coa hydrolase
T261_RS08440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS08460	COG4552	Acetyltransferase involved in intracellular survival and related
T261_RS08490	COG0583	DNA-binding transcription factor activity
T261_RS08495	COG1953	Uracil, thiamine, allantoin
T261_RS08500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS08505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
T261_RS08515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
T261_RS08535	COG0477	Major facilitator Superfamily
T261_RS08540	COG1335	isochorismatase
T261_RS08555	COG0405	Gamma-glutamyltransferase
T261_RS08565	COG0387	Pfam Sodium calcium exchanger
T261_RS08570	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS08585	COG2409	Drug exporters of the RND superfamily
T261_RS08600	COG0435	Glutathione S-transferase
T261_RS08625	COG0765	amino acid transport
T261_RS08630	COG0765	amino acid transport
T261_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T261_RS08640	COG1126	abc transporter atp-binding protein
T261_RS08665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS08675	COG1940	carbohydrate kinase activity
T261_RS08685	COG1172	Belongs to the binding-protein-dependent transport system permease family
T261_RS08690	COG1879	ABC-type sugar transport system periplasmic component
T261_RS08700	COG2188	Transcriptional regulator
T261_RS08705	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS08715	COG0800	Aldolase
T261_RS08725	COG2226	methyltransferase
T261_RS08735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T261_RS08750	COG4266	Belongs to the allantoicase family
T261_RS08755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
T261_RS08760	COG1953	Uracil, thiamine, allantoin
T261_RS08770	COG1414	Transcriptional regulator
T261_RS08795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
T261_RS08820	COG2233	PERMEase
T261_RS08830	COG2233	PERMEase
T261_RS08840	COG2351	hydroxyisourate hydrolase activity
T261_RS08860	COG3622	Belongs to the hyi family
T261_RS08865	COG2084	Dehydrogenase
T261_RS08870	COG0753	catalase activity
T261_RS08885	COG2315	Protein conserved in bacteria
T261_RS08895	COG1051	belongs to the nudix hydrolase family
T261_RS08900	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS08935	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS08950	COG0596	Alpha beta hydrolase
T261_RS08985	COG0583	DNA-binding transcription factor activity
T261_RS08990	COG4552	Acetyltransferase involved in intracellular survival and related
T261_RS09000	COG2252	PERMEase
T261_RS09005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS09035	COG1802	Transcriptional regulator
T261_RS09060	COG0028	Belongs to the TPP enzyme family
T261_RS09080	COG1162	GTPase activity
T261_RS09115	COG3903	Transcriptional regulator
T261_RS09115	COG3629	intracellular signal transduction
T261_RS09125	COG1309	transcriptional regulator
T261_RS09130	COG0531	amino acid
T261_RS09135	COG2957	Belongs to the agmatine deiminase family
T261_RS09145	COG3290	protein histidine kinase activity
T261_RS09155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T261_RS09160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T261_RS09160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
T261_RS09170	COG1215	transferase activity, transferring glycosyl groups
T261_RS09185	COG1716	ATPase activity
T261_RS09185	COG1131	(ABC) transporter
T261_RS09185	COG0842	Transport permease protein
T261_RS09195	COG2815	serine threonine protein kinase
T261_RS09195	COG0515	serine threonine protein kinase
T261_RS09210	COG1376	ErfK ybiS ycfS ynhG family protein
T261_RS09215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
T261_RS09220	COG3511	phospholipase C
T261_RS09255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T261_RS09270	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS09275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
T261_RS09280	COG2080	2 iron, 2 sulfur cluster binding
T261_RS09340	COG0596	Alpha beta hydrolase
T261_RS09345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
T261_RS09350	COG3485	protocatechuate 3,4-dioxygenase
T261_RS09355	COG3485	protocatechuate 3,4-dioxygenase
T261_RS09360	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
T261_RS09370	COG1414	Transcriptional regulator
T261_RS09375	COG2814	Major facilitator Superfamily
T261_RS09385	COG1960	acyl-CoA dehydrogenase activity
T261_RS09425	COG0175	sulfate reduction
T261_RS09430	COG0529	Catalyzes the synthesis of activated sulfate
T261_RS09450	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
T261_RS09455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
T261_RS09505	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS09530	COG0583	DNA-binding transcription factor activity
T261_RS09535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T261_RS09560	COG0693	protein deglycase activity
T261_RS09570	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
T261_RS09585	COG0300	oxidoreductase activity
T261_RS09595	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS09610	COG2304	oxidoreductase activity
T261_RS09615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T261_RS09620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
T261_RS09625	COG2197	response regulator
T261_RS09630	COG4585	Histidine kinase
T261_RS09640	COG1136	(ABC) transporter
T261_RS09675	COG1116	anion transmembrane transporter activity
T261_RS09690	COG1280	lysine exporter protein (LysE YggA)
T261_RS09710	COG3253	May function as heme-dependent peroxidase
T261_RS09715	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
T261_RS09725	COG0183	Belongs to the thiolase family
T261_RS09730	COG0446	pyridine nucleotide-disulphide oxidoreductase
T261_RS09745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
T261_RS09760	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
T261_RS09765	COG0183	Belongs to the thiolase family
T261_RS09770	COG1250	3-hydroxyacyl-CoA dehydrogenase
T261_RS09770	COG1024	Enoyl-CoA hydratase
T261_RS09780	COG0531	amino acid
T261_RS09785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
T261_RS09790	COG4214	carbohydrate transport
T261_RS09800	COG4213	ABC transporter substrate-binding protein
T261_RS09805	COG1940	carbohydrate kinase activity
T261_RS09810	COG0395	ABC-type sugar transport system, permease component
T261_RS09815	COG1175	transmembrane transport
T261_RS09820	COG1653	transport
T261_RS09830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
T261_RS09845	COG1595	DNA-templated transcription, initiation
T261_RS09860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T261_RS09890	COG0546	phosphoglycolate phosphatase activity
T261_RS09900	COG0604	alcohol dehydrogenase
T261_RS09900	COG3321	synthase
T261_RS09915	COG1024	Enoyl-CoA hydratase
T261_RS09930	COG0531	amino acid
T261_RS09935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
T261_RS09945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
T261_RS09975	COG1799	cell septum assembly
T261_RS10015	COG2264	protein methyltransferase activity
T261_RS10025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS10055	COG2814	Major facilitator Superfamily
T261_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS10070	COG0519	Catalyzes the synthesis of GMP from XMP
T261_RS10140	COG1231	oxidoreductase activity
T261_RS10150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T261_RS10165	COG3903	Transcriptional regulator
T261_RS10165	COG3629	intracellular signal transduction
T261_RS10180	COG1279	arginine transmembrane transporter activity
T261_RS10200	COG2192	nodulation
T261_RS10215	COG1834	amidinotransferase
T261_RS10225	COG0505	Belongs to the CarA family
T261_RS10230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
T261_RS10260	COG1309	transcriptional regulator
T261_RS10280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
T261_RS10285	COG0531	amino acid
T261_RS10295	COG0569	domain protein
T261_RS10330	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
T261_RS10335	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
T261_RS10340	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
T261_RS10355	COG0756	dUTP diphosphatase activity
T261_RS10380	COG2205	protein histidine kinase activity
T261_RS10385	COG0745	RESPONSE REGULATOR receiver
T261_RS10400	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
T261_RS10445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
T261_RS10485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS10495	COG2801	Transposase and inactivated derivatives
T261_RS10500	COG1435	thymidine kinase activity
T261_RS10635	COG1674	ftsk spoiiie
T261_RS10710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
T261_RS10715	COG1802	Transcriptional regulator
T261_RS10730	COG0612	Peptidase, M16
T261_RS10735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T261_RS10750	COG3290	protein histidine kinase activity
T261_RS10755	COG4565	transcriptional regulatory protein
T261_RS10760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
T261_RS10770	COG2197	response regulator
T261_RS10775	COG4585	Histidine kinase
T261_RS10785	COG0187	DNA topoisomerase II activity
T261_RS10800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T261_RS10805	COG2186	Transcriptional regulator
T261_RS10810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T261_RS10845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
T261_RS10855	COG0588	phosphoglycerate mutase activity
T261_RS10865	COG0488	(ABC) transporter
T261_RS10880	COG0154	amidase activity
T261_RS10885	COG3226	Transcriptional regulator
T261_RS10905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T261_RS10910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
T261_RS10915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
T261_RS10945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
T261_RS10955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
T261_RS10960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
T261_RS10970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
T261_RS10985	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T261_RS11020	COG1278	Cold shock
T261_RS11025	COG2205	protein histidine kinase activity
T261_RS11035	COG1126	abc transporter atp-binding protein
T261_RS11045	COG0765	amino acid transport
T261_RS11050	COG0765	amino acid transport
T261_RS11055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS11085	COG0628	permease
T261_RS11115	COG1201	RNA secondary structure unwinding
T261_RS11120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
T261_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS11135	COG0783	Belongs to the Dps family
T261_RS11140	COG1396	sequence-specific DNA binding
T261_RS11145	COG1546	Belongs to the CinA family
T261_RS11145	COG1058	Belongs to the CinA family
T261_RS11155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T261_RS11165	COG1674	ftsk spoiiie
T261_RS11175	COG3437	response regulator, receiver
T261_RS11175	COG4999	Histidine kinase
T261_RS11175	COG3850	Histidine kinase
T261_RS11175	COG2205	protein histidine kinase activity
T261_RS11180	COG2208	phosphoserine phosphatase activity
T261_RS11180	COG2770	Histidine kinase
T261_RS11215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
T261_RS11220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
T261_RS11225	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
T261_RS11245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
T261_RS11250	COG0612	Peptidase, M16
T261_RS11255	COG1185	polyribonucleotide nucleotidyltransferase activity
T261_RS11260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
T261_RS11270	COG1674	ftsk spoiiie
T261_RS11330	COG1404	Belongs to the peptidase S8 family
T261_RS11360	COG0455	bacterial-type flagellum organization
T261_RS11375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
T261_RS11380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
T261_RS11390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
T261_RS11400	COG0779	Required for maturation of 30S ribosomal subunits
T261_RS11415	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
T261_RS11420	COG0442	prolyl-tRNA aminoacylation
T261_RS11435	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
T261_RS11440	COG0750	zinc metalloprotease
T261_RS11445	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
T261_RS11455	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS11485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T261_RS11490	COG1177	transmembrane transport
T261_RS11495	COG1176	ABC-type spermidine putrescine transport system, permease component I
T261_RS11500	COG3842	ATPase activity
T261_RS11525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
T261_RS11545	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS11555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
T261_RS11560	COG1136	(ABC) transporter
T261_RS11600	COG3842	ATPase activity
T261_RS11605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
T261_RS11615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
T261_RS11625	COG0233	cytoplasmic translational termination
T261_RS11630	COG0528	UMP kinase activity
T261_RS11635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
T261_RS11640	COG0052	Belongs to the universal ribosomal protein uS2 family
T261_RS11650	COG1191	sigma factor activity
T261_RS11665	COG0792	nuclease activity
T261_RS11675	COG1051	belongs to the nudix hydrolase family
T261_RS11680	COG0681	Belongs to the peptidase S26 family
T261_RS11685	COG0681	Belongs to the peptidase S26 family
T261_RS11690	COG0681	Belongs to the peptidase S26 family
T261_RS11695	COG0681	Belongs to the peptidase S26 family
T261_RS11700	COG0335	large ribosomal subunit rRNA binding
T261_RS11705	COG0336	Belongs to the RNA methyltransferase TrmD family
T261_RS11710	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
T261_RS11715	COG1837	Belongs to the UPF0109 family
T261_RS11720	COG0228	four-way junction DNA binding
T261_RS11740	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
T261_RS11775	COG1252	NADH dehydrogenase
T261_RS11780	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
T261_RS11795	COG0477	Major facilitator Superfamily
T261_RS11800	COG1196	nuclear chromosome segregation
T261_RS11810	COG1254	Belongs to the acylphosphatase family
T261_RS11815	COG2340	Cysteine-rich secretory protein family
T261_RS11830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
T261_RS11835	COG0571	ribonuclease III activity
T261_RS11840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
T261_RS11855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
T261_RS11860	COG0742	ribosomal rna small subunit methyltransferase
T261_RS11870	COG1461	Dihydroxyacetone kinase
T261_RS11875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
T261_RS11880	COG0351	phosphomethylpyrimidine kinase
T261_RS11900	COG1181	Belongs to the D-alanine--D-alanine ligase family
T261_RS11905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
T261_RS11915	COG1920	GTP binding
T261_RS11925	COG0776	regulation of translation
T261_RS11935	COG0066	3-isopropylmalate dehydratase activity
T261_RS11940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
T261_RS11945	COG1414	Transcriptional regulator
T261_RS11995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
T261_RS12000	COG0179	Fumarylacetoacetate (FAA) hydrolase
T261_RS12015	COG2018	Roadblock/LC7 domain
T261_RS12035	COG2018	Roadblock/LC7 domain
T261_RS12060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
T261_RS12065	COG5492	domain, Protein
T261_RS12075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
T261_RS12085	COG1309	transcriptional regulator
T261_RS12090	COG2957	Belongs to the agmatine deiminase family
T261_RS12095	COG0804	urea catabolic process
T261_RS12100	COG0831	urea catabolic process
T261_RS12100	COG0832	Belongs to the urease beta subunit family
T261_RS12110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T261_RS12115	COG0473	3-isopropylmalate dehydrogenase activity
T261_RS12130	COG0575	Belongs to the CDS family
T261_RS12145	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS12150	COG0506	proline dehydrogenase activity
T261_RS12155	COG3835	regulator
T261_RS12175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T261_RS12180	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
T261_RS12185	COG0440	acetolactate synthase activity
T261_RS12195	COG5001	Diguanylate cyclase
T261_RS12195	COG3300	MHYT domain
T261_RS12205	COG0656	L-ascorbic acid biosynthetic process
T261_RS12210	COG2133	pyrroloquinoline quinone binding
T261_RS12225	COG1672	PFAM Archaeal ATPase
T261_RS12225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
T261_RS12240	COG2409	Drug exporters of the RND superfamily
T261_RS12265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
T261_RS12275	COG0154	amidase activity
T261_RS12280	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
T261_RS12295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
T261_RS12315	COG4221	oxidoreductase activity
T261_RS12320	COG1611	Belongs to the LOG family
T261_RS12325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
T261_RS12350	COG0482	sulfurtransferase activity
T261_RS12395	COG2860	membrane
T261_RS12400	COG0308	aminopeptidase N
T261_RS12405	COG4608	Belongs to the ABC transporter superfamily
T261_RS12410	COG0444	Belongs to the ABC transporter superfamily
T261_RS12445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
T261_RS12450	COG0509	glycine decarboxylation via glycine cleavage system
T261_RS12455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
T261_RS12460	COG1760	l-serine dehydratase
T261_RS12475	COG0671	phosphoesterase, PA-phosphatase related
T261_RS12495	COG0745	RESPONSE REGULATOR receiver
T261_RS12505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T261_RS12515	COG0785	Cytochrome C biogenesis protein
T261_RS12520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
T261_RS12520	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
T261_RS12555	COG1132	(ABC) transporter
T261_RS12560	COG1132	(ABC) transporter
T261_RS12580	COG2197	response regulator
T261_RS12585	COG4585	Histidine kinase
T261_RS12590	COG0366	Alpha amylase catalytic
T261_RS12595	COG0366	Alpha amylase catalytic
T261_RS12605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
T261_RS12610	COG1301	dicarboxylic acid transport
T261_RS12615	COG3290	protein histidine kinase activity
T261_RS12620	COG4565	transcriptional regulatory protein
T261_RS12630	COG1175	transmembrane transport
T261_RS12635	COG0395	ABC-type sugar transport system, permease component
T261_RS12645	COG1136	(ABC) transporter
T261_RS12650	COG0577	efflux transmembrane transporter activity
T261_RS12655	COG0205	6-phosphofructokinase activity
T261_RS12660	COG0857	belongs to the CobB CobQ family
T261_RS12660	COG0280	phosphate acetyltransferase
T261_RS12665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
T261_RS12705	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
T261_RS12710	COG0745	RESPONSE REGULATOR receiver
T261_RS12715	COG2205	protein histidine kinase activity
T261_RS12720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS12720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS12775	COG2205	protein histidine kinase activity
T261_RS12780	COG0745	RESPONSE REGULATOR receiver
T261_RS12795	COG0183	Belongs to the thiolase family
T261_RS12850	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
T261_RS12865	COG1250	3-hydroxyacyl-CoA dehydrogenase
T261_RS12895	COG4585	Histidine kinase
T261_RS12900	COG2197	response regulator
T261_RS12910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
T261_RS12915	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
T261_RS12920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
T261_RS12925	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
T261_RS12930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T261_RS12935	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
T261_RS12940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T261_RS12960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
T261_RS12965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
T261_RS12975	COG2890	protein-(glutamine-N5) methyltransferase activity
T261_RS12980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
T261_RS12985	COG0254	rRNA binding
T261_RS13000	COG0083	homoserine kinase activity
T261_RS13005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
T261_RS13010	COG0460	homoserine dehydrogenase
T261_RS13015	COG0019	diaminopimelate decarboxylase activity
T261_RS13020	COG0018	arginyl-trna synthetase
T261_RS13045	COG2124	cytochrome p450
T261_RS13060	COG0768	penicillin binding
T261_RS13070	COG1119	ATPase activity
T261_RS13150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
T261_RS13155	COG1357	PFAM Pentapeptide repeats (8 copies)
T261_RS13175	COG0745	RESPONSE REGULATOR receiver
T261_RS13180	COG2205	protein histidine kinase activity
T261_RS13185	COG0508	dehydrogenase complex catalyzes the overall conversion of
T261_RS13185	COG0567	Dehydrogenase, E1 component
T261_RS13210	COG2255	four-way junction helicase activity
T261_RS13275	COG0604	alcohol dehydrogenase
T261_RS13280	COG0281	malic enzyme
T261_RS13290	COG0765	amino acid transport
T261_RS13295	COG1126	abc transporter atp-binding protein
T261_RS13300	COG4106	trans-aconitate 2-methyltransferase activity
T261_RS13330	COG0583	DNA-binding transcription factor activity
T261_RS13350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
T261_RS13355	COG1993	acr, cog1993
T261_RS13360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
T261_RS13365	COG2186	Transcriptional regulator
T261_RS13370	COG2807	transmembrane transport
T261_RS13375	COG0598	Magnesium transport protein CorA
T261_RS13380	COG0477	Major facilitator Superfamily
T261_RS13400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T261_RS13410	COG2066	Belongs to the glutaminase family
T261_RS13425	COG2515	1-aminocyclopropane-1-carboxylate deaminase
T261_RS13460	COG1597	lipid kinase activity
T261_RS13475	COG1309	transcriptional regulator
T261_RS13480	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS13485	COG0363	glucosamine-6-phosphate deaminase activity
T261_RS13490	COG1472	Belongs to the glycosyl hydrolase 3 family
T261_RS13495	COG0395	ABC-type sugar transport system, permease component
T261_RS13500	COG1175	transmembrane transport
T261_RS13505	COG2182	Extracellular solute-binding protein
T261_RS13510	COG2188	Transcriptional regulator
T261_RS13535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
T261_RS13540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T261_RS13545	COG0242	peptide deformylase activity
T261_RS13565	COG5662	AntiSigma factor
T261_RS13570	COG1595	DNA-templated transcription, initiation
T261_RS13580	COG2135	peptidase activity
T261_RS13590	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
T261_RS13595	COG1162	GTPase activity
T261_RS13600	COG2076	Multidrug Resistance protein
T261_RS13610	COG0483	inositol monophosphate 1-phosphatase activity
T261_RS13620	COG0753	catalase activity
T261_RS13645	COG1615	UPF0182 protein
T261_RS13655	COG3480	Lon protease (S16) C-terminal proteolytic domain
T261_RS13710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
T261_RS13750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T261_RS13820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T261_RS13835	COG2267	carboxylic ester hydrolase activity
T261_RS13865	COG0513	Belongs to the DEAD box helicase family
T261_RS13880	COG1432	Conserved Protein
T261_RS13885	COG2095	MarC family integral membrane protein
T261_RS13905	COG0598	Magnesium transport protein CorA
T261_RS13945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
T261_RS13950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T261_RS13960	COG1595	DNA-templated transcription, initiation
T261_RS13970	COG1024	Enoyl-CoA hydratase
T261_RS13975	COG0519	Catalyzes the synthesis of GMP from XMP
T261_RS13985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
T261_RS13990	COG1611	Belongs to the LOG family
T261_RS13995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T261_RS14035	COG2197	response regulator
T261_RS14050	COG4585	Histidine kinase
T261_RS14060	COG1131	(ABC) transporter
T261_RS14075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
T261_RS14100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T261_RS14105	COG4166	transmembrane transport
T261_RS14110	COG0601	transmembrane transport
T261_RS14115	COG0444	Belongs to the ABC transporter superfamily
T261_RS14120	COG4608	Belongs to the ABC transporter superfamily
T261_RS14125	COG4608	Belongs to the ABC transporter superfamily
T261_RS14135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T261_RS14140	COG0601	transmembrane transport
T261_RS14145	COG4166	transmembrane transport
T261_RS14150	COG0154	amidase activity
T261_RS14180	COG1217	gtp-binding protein TYPA
T261_RS14200	COG1053	succinate dehydrogenase
T261_RS14210	COG0402	S-adenosylhomocysteine deaminase activity
T261_RS14235	COG0531	amino acid
T261_RS14250	COG0596	Alpha beta hydrolase
T261_RS14250	COG0508	dehydrogenase complex catalyzes the overall conversion of
T261_RS14270	COG0012	GTP binding
T261_RS14280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
T261_RS14290	COG1570	exodeoxyribonuclease VII activity
T261_RS14295	COG1722	exodeoxyribonuclease VII activity
T261_RS14300	COG0778	Nitroreductase
T261_RS14325	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
T261_RS14325	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
T261_RS14340	COG0114	fumarate hydratase activity
T261_RS14350	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
T261_RS14365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T261_RS14395	COG1136	(ABC) transporter
T261_RS14425	COG0450	alkyl hydroperoxide reductase
T261_RS14430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS14445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
T261_RS14450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
T261_RS14455	COG0667	Aldo Keto reductase
T261_RS14535	COG2894	cell division
T261_RS14565	COG2610	gluconate transmembrane transporter activity
T261_RS14570	COG0251	oxidation-reduction process
T261_RS14575	COG1414	Transcriptional regulator
T261_RS14590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
T261_RS14610	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
T261_RS14625	COG0789	Transcriptional regulator
T261_RS14630	COG0154	amidase activity
T261_RS14640	COG1331	Highly conserved protein containing a thioredoxin domain
T261_RS14655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
T261_RS14665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
T261_RS14680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
T261_RS14685	COG2255	four-way junction helicase activity
T261_RS14690	COG1595	DNA-templated transcription, initiation
T261_RS14710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
T261_RS14755	COG1113	amino acid transport
T261_RS14770	COG1376	ErfK ybiS ycfS ynhG family protein
T261_RS14785	COG2986	histidine ammonia-lyase
T261_RS14795	COG1024	Enoyl-CoA hydratase
T261_RS14800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
T261_RS14810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
T261_RS14820	COG0768	penicillin binding
T261_RS14825	COG0424	maF-like protein
T261_RS14890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T261_RS14905	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS14910	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS14945	COG1595	DNA-templated transcription, initiation
T261_RS14950	COG0745	RESPONSE REGULATOR receiver
T261_RS14955	COG2205	protein histidine kinase activity
T261_RS14980	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
T261_RS14990	COG0583	DNA-binding transcription factor activity
T261_RS14995	COG2814	Major facilitator Superfamily
T261_RS15010	COG1079	Belongs to the binding-protein-dependent transport system permease family
T261_RS15015	COG4603	Belongs to the binding-protein-dependent transport system permease family
T261_RS15020	COG3845	ABC transporter
T261_RS15025	COG1744	ABC transporter substrate-binding protein PnrA-like
T261_RS15030	COG1473	amidohydrolase
T261_RS15030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
T261_RS15040	COG2089	acid synthase
T261_RS15045	COG1083	cytidylyl-transferase
T261_RS15055	COG1216	Glycosyl transferase, family 2
T261_RS15065	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
T261_RS15085	COG3265	gluconokinase activity
T261_RS15105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS15105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS15120	COG1595	DNA-templated transcription, initiation
T261_RS15135	COG2009	succinate dehydrogenase
T261_RS15145	COG1053	succinate dehydrogenase
T261_RS15160	COG0789	Transcriptional regulator
T261_RS15195	COG1408	metallophosphoesterase
T261_RS15250	COG1295	ribonuclease BN
T261_RS15260	COG0180	Tryptophanyl-tRNA synthetase
T261_RS15265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
T261_RS15270	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
T261_RS15275	COG0754	glutathionylspermidine amidase activity
T261_RS15290	COG0456	acetyltransferase
T261_RS15295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
T261_RS15350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS15355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS15365	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS15370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS15410	COG4176	ABC-type proline glycine betaine transport system permease component
T261_RS15415	COG0517	IMP dehydrogenase activity
T261_RS15415	COG4175	Glycine betaine
T261_RS15425	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS15475	COG0039	L-malate dehydrogenase activity
T261_RS15490	COG0538	isocitrate dehydrogenase activity
T261_RS15500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
T261_RS15515	COG0138	bifunctional purine biosynthesis protein purh
T261_RS15545	COG0045	succinate-CoA ligase (ADP-forming) activity
T261_RS15660	COG3552	Protein containing von Willebrand factor type A (VWA) domain
T261_RS15665	COG2425	protein containing a von Willebrand factor type A (vWA) domain
T261_RS15670	COG0714	Associated with various cellular activities
T261_RS15685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
T261_RS15725	COG2197	response regulator
T261_RS15740	COG0515	serine threonine protein kinase
T261_RS15780	COG2084	Dehydrogenase
T261_RS15790	COG0519	Catalyzes the synthesis of GMP from XMP
T261_RS15790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
T261_RS15815	COG0515	serine threonine protein kinase
T261_RS15835	COG4585	Histidine kinase
T261_RS15885	COG1131	(ABC) transporter
T261_RS15905	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
T261_RS15905	COG0515	serine threonine protein kinase
T261_RS15920	COG4821	SIS domain
T261_RS15930	COG0259	pyridoxamine-phosphate oxidase activity
T261_RS15970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
T261_RS15985	COG5006	permease, DMT superfamily
T261_RS15990	COG0583	DNA-binding transcription factor activity
T261_RS16010	COG0596	Alpha beta hydrolase
T261_RS16015	COG0247	lactate metabolic process
T261_RS16015	COG0277	FAD linked oxidase domain protein
T261_RS16025	COG2378	regulation of single-species biofilm formation
T261_RS16030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
T261_RS16085	COG0667	Aldo Keto reductase
T261_RS16110	COG2252	PERMEase
T261_RS16120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T261_RS16130	COG3209	COG3209 Rhs family protein
T261_RS16155	COG2814	Major facilitator Superfamily
T261_RS16165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
T261_RS16170	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
T261_RS16175	COG1278	Cold shock
T261_RS16250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
T261_RS16255	COG1061	Type III restriction enzyme res subunit
T261_RS16270	COG3973	AAA domain
T261_RS16275	COG3142	Participates in the control of copper homeostasis
T261_RS16325	COG1737	Transcriptional regulator
T261_RS16330	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
T261_RS16340	COG2814	Major facilitator Superfamily
T261_RS16355	COG2207	Transcriptional regulator
T261_RS16355	COG3708	Transcriptional regulator
T261_RS16370	COG1278	Cold shock
T261_RS16385	COG0463	Glycosyl transferase, family 2
T261_RS16410	COG1940	carbohydrate kinase activity
T261_RS16415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
T261_RS16420	COG1105	Belongs to the carbohydrate kinase PfkB family
T261_RS16440	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
T261_RS16470	COG2197	response regulator
T261_RS16500	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS16530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T261_RS16535	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS16540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T261_RS16545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS16550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS16555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
T261_RS16570	COG1017	nitric oxide dioxygenase activity
T261_RS16570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
T261_RS16630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
T261_RS16645	COG3842	ATPase activity
T261_RS16655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
T261_RS16670	COG0215	cysteine-tRNA ligase activity
T261_RS16680	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
T261_RS16685	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
T261_RS16690	COG1329	Transcriptional regulator
T261_RS16705	COG5002	protein histidine kinase activity
T261_RS16720	COG0588	phosphoglycerate mutase activity
T261_RS16755	COG0438	transferase activity, transferring glycosyl groups
T261_RS16770	COG0667	Aldo Keto reductase
T261_RS16775	COG0583	DNA-binding transcription factor activity
T261_RS16810	COG0596	Alpha beta hydrolase
T261_RS16815	COG0406	alpha-ribazole phosphatase activity
T261_RS16815	COG0494	nUDIX hydrolase
T261_RS16825	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
T261_RS16830	COG1132	(ABC) transporter
T261_RS16895	COG0456	acetyltransferase
T261_RS16905	COG0737	Belongs to the 5'-nucleotidase family
T261_RS16925	COG0702	epimerase
T261_RS16940	COG0745	RESPONSE REGULATOR receiver
T261_RS16945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T261_RS16950	COG1609	Transcriptional regulator
T261_RS16955	COG0745	RESPONSE REGULATOR receiver
T261_RS16970	COG1309	transcriptional regulator
T261_RS17005	COG2897	thiosulfate sulfurtransferase activity
T261_RS17030	COG3485	protocatechuate 3,4-dioxygenase
T261_RS17035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T261_RS17040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
T261_RS17045	COG4607	ABC-type enterochelin transport system periplasmic component
T261_RS17050	COG0735	belongs to the Fur family
T261_RS17055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
T261_RS17060	COG1490	D-aminoacyl-tRNA deacylase activity
T261_RS17075	COG4552	Acetyltransferase involved in intracellular survival and related
T261_RS17085	COG0431	NADPH-dependent FMN reductase
T261_RS17105	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS17125	COG0667	Aldo Keto reductase
T261_RS17135	COG2890	protein-(glutamine-N5) methyltransferase activity
T261_RS17170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
T261_RS17245	COG0306	phosphate transporter
T261_RS17255	COG1937	Protein conserved in bacteria
T261_RS17270	COG0277	FAD linked oxidase domain protein
T261_RS17275	COG0671	phosphoesterase, PA-phosphatase related
T261_RS17280	COG1196	nuclear chromosome segregation
T261_RS17280	COG0741	lytic transglycosylase activity
T261_RS17280	COG0739	heme binding
T261_RS17325	COG2132	Multicopper oxidase
T261_RS17330	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T261_RS17330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T261_RS17340	COG0180	Tryptophanyl-tRNA synthetase
T261_RS17345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
T261_RS17355	COG0842	Transport permease protein
T261_RS17355	COG1129	ABC transporter
T261_RS17370	COG0308	aminopeptidase N
T261_RS17430	COG0129	dihydroxy-acid dehydratase activity
T261_RS17440	COG1082	Xylose isomerase domain protein TIM barrel
T261_RS17445	COG0248	Ppx GppA phosphatase
T261_RS17465	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
T261_RS17485	COG1194	a g-specific adenine glycosylase
T261_RS17490	COG1595	DNA-templated transcription, initiation
T261_RS17500	COG0745	RESPONSE REGULATOR receiver
T261_RS17505	COG2205	protein histidine kinase activity
T261_RS17555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
T261_RS17575	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
T261_RS17585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
T261_RS17590	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
T261_RS17625	COG0667	Aldo Keto reductase
T261_RS17635	COG0640	Transcriptional regulator
T261_RS17640	COG2197	response regulator
T261_RS17655	COG0649	NAD binding
T261_RS17675	COG1174	glycine betaine transport
T261_RS17680	COG1174	glycine betaine transport
T261_RS17690	COG1125	glycine betaine transport
T261_RS17690	COG0517	IMP dehydrogenase activity
T261_RS17705	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
T261_RS17710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
T261_RS17725	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
T261_RS17725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
T261_RS17735	COG0302	gtp cyclohydrolase
T261_RS17750	COG0037	tRNA processing
T261_RS17760	COG2027	D-alanyl-D-alanine carboxypeptidase
T261_RS17765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
T261_RS17775	COG0586	Pfam SNARE associated Golgi protein
T261_RS17780	COG0393	Putative heavy-metal-binding
T261_RS17785	COG0789	Transcriptional regulator
T261_RS17835	COG0655	NAD(P)H dehydrogenase (quinone) activity
T261_RS17840	COG0076	glutamate decarboxylase activity
T261_RS17870	COG2318	DinB family
T261_RS17875	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS17905	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
T261_RS17915	COG0254	rRNA binding
T261_RS17920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T261_RS17925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
T261_RS17930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
T261_RS17935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
T261_RS17940	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T261_RS17940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T261_RS17980	COG3594	Acyltransferase
T261_RS17985	COG0584	glycerophosphoryl diester phosphodiesterase
T261_RS18000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T261_RS18005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
T261_RS18010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
T261_RS18010	COG1754	DNA topoisomerase type I activity
T261_RS18035	COG2890	protein-(glutamine-N5) methyltransferase activity
T261_RS18045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
T261_RS18055	COG1366	Belongs to the anti-sigma-factor antagonist family
T261_RS18060	COG1111	helicase
T261_RS18060	COG1205	dead DEAH box helicase
T261_RS18110	COG4974	Belongs to the 'phage' integrase family
T261_RS18140	COG0659	secondary active sulfate transmembrane transporter activity
T261_RS18145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
T261_RS18150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
T261_RS18160	COG2267	carboxylic ester hydrolase activity
T261_RS18185	COG2957	Belongs to the agmatine deiminase family
T261_RS18190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T261_RS18210	COG0003	Pfam Anion-transporting ATPase
T261_RS18220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T261_RS18230	COG1408	metallophosphoesterase
T261_RS18255	COG4249	Peptidase C14 caspase catalytic subunit p20
T261_RS18255	COG2319	Wd-40 repeat
T261_RS18260	COG2188	Transcriptional regulator
T261_RS18295	COG2197	response regulator
T261_RS18300	COG4585	Histidine kinase
T261_RS18305	COG1316	TRANSCRIPTIONal
T261_RS18310	COG1215	transferase activity, transferring glycosyl groups
T261_RS18315	COG0531	amino acid
T261_RS18325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
T261_RS18350	COG1595	DNA-templated transcription, initiation
T261_RS18370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
T261_RS18375	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
T261_RS18395	COG2124	cytochrome p450
T261_RS18405	COG2226	methyltransferase
T261_RS18410	COG0640	Transcriptional regulator
T261_RS18415	COG0798	PFAM Bile acid sodium symporter
T261_RS18420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
T261_RS18435	COG1132	(ABC) transporter
T261_RS18445	COG1113	amino acid transport
T261_RS18475	COG0277	FAD linked oxidase domain protein
T261_RS18505	COG0402	S-adenosylhomocysteine deaminase activity
T261_RS18510	COG0477	Major facilitator Superfamily
T261_RS18515	COG2188	Transcriptional regulator
T261_RS18520	COG1522	sequence-specific DNA binding
T261_RS18525	COG1834	amidinotransferase
T261_RS18530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
T261_RS18580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS18590	COG0477	Major facilitator Superfamily
T261_RS18610	COG2268	Band 7 protein
T261_RS18640	COG1064	alcohol dehydrogenase
T261_RS18680	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
T261_RS18695	COG0590	tRNA wobble adenosine to inosine editing
T261_RS18705	COG3831	ATPase activity
T261_RS18725	COG1191	sigma factor activity
T261_RS18730	COG1191	sigma factor activity
T261_RS18760	COG0477	Major facilitator Superfamily
T261_RS18765	COG2353	YceI-like domain
T261_RS18800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
T261_RS18830	COG0477	Major facilitator Superfamily
T261_RS18835	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
T261_RS18845	COG2205	protein histidine kinase activity
T261_RS18850	COG0745	RESPONSE REGULATOR receiver
T261_RS18875	COG2249	NAD(P)H dehydrogenase (quinone) activity
T261_RS18895	COG2409	Drug exporters of the RND superfamily
T261_RS18980	COG0582	viral genome integration into host DNA
T261_RS19000	COG2188	Transcriptional regulator
T261_RS19080	COG0784	Response regulator, receiver
T261_RS19085	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS19100	COG3437	response regulator, receiver
T261_RS19110	COG1595	DNA-templated transcription, initiation
T261_RS19125	COG1960	acyl-CoA dehydrogenase activity
T261_RS19135	COG1960	acyl-CoA dehydrogenase activity
T261_RS19180	COG1714	RDD family
T261_RS19195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T261_RS19230	COG0006	proline dipeptidase activity
T261_RS19255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
T261_RS19275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T261_RS19305	COG2372	response to copper ion
T261_RS19310	COG2837	iron assimilation
T261_RS19320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
T261_RS19325	COG0561	phosphatase activity
T261_RS19355	COG2186	Transcriptional regulator
T261_RS19360	COG2807	transmembrane transport
T261_RS19365	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
T261_RS19385	COG1131	(ABC) transporter
T261_RS19405	COG0789	Transcriptional regulator
T261_RS19410	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
T261_RS19425	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
T261_RS19435	COG0501	Belongs to the peptidase M48B family
T261_RS19445	COG0561	phosphatase activity
T261_RS19450	COG0739	heme binding
T261_RS19460	COG4988	ABC transporter
T261_RS19465	COG1294	oxidase, subunit
T261_RS19470	COG1271	oxidase subunit
T261_RS19480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
T261_RS19485	COG1609	Transcriptional regulator
T261_RS19500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
T261_RS19525	COG0662	Cupin 2, conserved barrel domain protein
T261_RS19530	COG1950	PFAM Membrane protein of
T261_RS19535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
T261_RS19540	COG0626	cystathionine gamma-synthase activity
T261_RS19575	COG2814	Major facilitator Superfamily
T261_RS19580	COG1846	Transcriptional regulator
T261_RS19610	COG0789	Transcriptional regulator
T261_RS19610	COG4978	Transcriptional regulator
T261_RS19615	COG2197	response regulator
T261_RS19620	COG4585	Histidine kinase
T261_RS19630	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS19635	COG1309	transcriptional regulator
T261_RS19650	COG0305	Participates in initiation and elongation during chromosome replication
T261_RS19665	COG0359	binds to the 23S rRNA
T261_RS19670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
T261_RS19675	COG0629	single-stranded DNA binding
T261_RS19680	COG0360	Binds together with S18 to 16S ribosomal RNA
T261_RS19705	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
T261_RS19730	COG0617	tRNA 3'-terminal CCA addition
T261_RS19745	COG2815	serine threonine protein kinase
T261_RS19745	COG0515	serine threonine protein kinase
T261_RS19750	COG1595	DNA-templated transcription, initiation
T261_RS19760	COG0492	ferredoxin-NADP+ reductase activity
T261_RS19765	COG3118	belongs to the thioredoxin family
T261_RS19780	COG1192	Involved in chromosome partitioning
T261_RS19785	COG0357	Ribosomal RNA small subunit methyltransferase G
T261_RS19790	COG1847	R3H domain protein
T261_RS19795	COG0706	membrane insertase activity
T261_RS19800	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
T261_RS19805	COG0594	ribonuclease P activity
T261_RS19810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
T261_RS19820	COG0592	DNA-directed DNA polymerase activity
T261_RS19825	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
T261_RS19830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
T261_RS19835	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
T261_RS19840	COG0187	DNA topoisomerase II activity
T261_RS19845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T261_RS19870	COG0515	serine threonine protein kinase
T261_RS19900	COG0705	Rhomboid family
T261_RS19915	COG3764	Sortase (surface protein transpeptidase)
T261_RS19930	COG3764	Sortase (surface protein transpeptidase)
T261_RS19935	COG3764	Sortase (surface protein transpeptidase)
T261_RS19940	COG0515	serine threonine protein kinase
T261_RS19945	COG0768	penicillin binding
T261_RS19960	COG1716	ATPase activity
T261_RS19965	COG1716	ATPase activity
T261_RS19975	COG0583	DNA-binding transcription factor activity
T261_RS19980	COG2814	Major facilitator Superfamily
T261_RS19985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
T261_RS19990	COG1733	regulation of RNA biosynthetic process
T261_RS20025	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
T261_RS20030	COG2151	metal-sulfur cluster biosynthetic enzyme
T261_RS20035	COG3396	Phenylacetate-CoA oxygenase
T261_RS20040	COG3460	Phenylacetate-CoA oxygenase
T261_RS20045	COG3396	Phenylacetate-CoA oxygenase
T261_RS20070	COG1250	3-hydroxyacyl-CoA dehydrogenase
T261_RS20075	COG1309	transcriptional regulator
T261_RS20080	COG1522	sequence-specific DNA binding
T261_RS20105	COG0303	'Molybdopterin
T261_RS20110	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
T261_RS20130	COG0515	serine threonine protein kinase
T261_RS20135	COG0515	serine threonine protein kinase
T261_RS20160	COG0022	dehydrogenase e1 component
T261_RS20165	COG0508	dehydrogenase complex catalyzes the overall conversion of
T261_RS20230	COG3903	Transcriptional regulator
T261_RS20230	COG3629	intracellular signal transduction
T261_RS20235	COG1362	aminopeptidase activity
T261_RS20240	COG1960	acyl-CoA dehydrogenase activity
T261_RS20270	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
T261_RS20275	COG2826	transposase and inactivated derivatives, IS30 family
T261_RS20280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T261_RS20305	COG1174	glycine betaine transport
T261_RS20310	COG1174	glycine betaine transport
T261_RS20325	COG2205	protein histidine kinase activity
T261_RS20330	COG0745	RESPONSE REGULATOR receiver
T261_RS20335	COG1136	(ABC) transporter
T261_RS20335	COG0577	efflux transmembrane transporter activity
T261_RS20340	COG0577	efflux transmembrane transporter activity
T261_RS20340	COG1136	(ABC) transporter
T261_RS20365	COG2124	cytochrome p450
T261_RS20395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
T261_RS20420	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
T261_RS20480	COG1316	TRANSCRIPTIONal
T261_RS20520	COG2197	response regulator
T261_RS20525	COG4585	Histidine kinase
T261_RS20535	COG1131	(ABC) transporter
T261_RS20555	COG2197	response regulator
T261_RS20605	COG2301	Belongs to the HpcH HpaI aldolase family
T261_RS20615	COG4585	Histidine kinase
T261_RS20620	COG2197	response regulator
T261_RS20630	COG0681	Belongs to the peptidase S26 family
T261_RS20655	COG0583	DNA-binding transcription factor activity
T261_RS20680	COG1695	Transcriptional regulator
T261_RS20685	COG0583	DNA-binding transcription factor activity
T261_RS20695	COG0477	Major facilitator Superfamily
T261_RS20715	COG1595	DNA-templated transcription, initiation
T261_RS20745	COG0432	Pfam Uncharacterised protein family UPF0047
T261_RS20780	COG0346	lactoylglutathione lyase activity
T261_RS20790	COG0577	efflux transmembrane transporter activity
T261_RS20790	COG1136	(ABC) transporter
T261_RS20810	COG4585	Histidine kinase
T261_RS20815	COG2197	response regulator
T261_RS20830	COG0717	Belongs to the dCTP deaminase family
T261_RS20840	COG2755	lipolytic protein G-D-S-L family
T261_RS20855	COG0328	RNA-DNA hybrid ribonuclease activity
T261_RS20870	COG0247	lactate metabolic process
T261_RS20870	COG2181	nitrate reductase activity
T261_RS20875	COG0443	Heat shock 70 kDa protein
T261_RS20880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
T261_RS20885	COG0484	heat shock protein binding
T261_RS20890	COG0789	Transcriptional regulator
T261_RS20910	COG0542	response to heat
T261_RS20950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
T261_RS20965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
T261_RS20970	COG0191	fructose-bisphosphate aldolase activity
T261_RS20975	COG0477	Major facilitator Superfamily
T261_RS20985	COG3483	tryptophan 2,3-dioxygenase activity
T261_RS20990	COG3844	kynureninase activity
T261_RS21000	COG4585	Histidine kinase
T261_RS21005	COG2197	response regulator
T261_RS21015	COG3559	Exporter of polyketide antibiotics
T261_RS21020	COG1131	(ABC) transporter
T261_RS21035	COG2197	response regulator
T261_RS21045	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
T261_RS21050	COG1846	Transcriptional regulator
T261_RS21110	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
T261_RS21115	COG1802	Transcriptional regulator
T261_RS21130	COG0151	Belongs to the GarS family
T261_RS21145	COG0583	DNA-binding transcription factor activity
T261_RS21155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
T261_RS21165	COG2197	response regulator
T261_RS21200	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T261_RS21205	COG0047	phosphoribosylformylglycinamidine synthase activity
T261_RS21210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T261_RS21230	COG3119	arylsulfatase activity
T261_RS21240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
T261_RS21270	COG1643	Atp-dependent helicase
T261_RS21310	COG0513	Belongs to the DEAD box helicase family
T261_RS21320	COG2815	serine threonine protein kinase
T261_RS21320	COG0515	serine threonine protein kinase
T261_RS21340	COG0667	Aldo Keto reductase
T261_RS21360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
T261_RS21365	COG0579	oxidoreductase
T261_RS21390	COG1252	NADH dehydrogenase
T261_RS21405	COG1846	Transcriptional regulator
T261_RS21425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T261_RS21435	COG0123	including yeast histone deacetylase and acetoin utilization protein
T261_RS21480	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
T261_RS21485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
T261_RS21490	COG0181	hydroxymethylbilane synthase activity
T261_RS21495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
T261_RS21495	COG1648	precorrin-2 dehydrogenase activity
T261_RS21500	COG0113	porphobilinogen synthase activity
T261_RS21520	COG0018	arginyl-trna synthetase
T261_RS21525	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
T261_RS21565	COG1690	Belongs to the RtcB family
T261_RS21570	COG1846	Transcriptional regulator
T261_RS21590	COG1742	UPF0060 membrane protein
T261_RS21600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS21615	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS21630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
T261_RS21635	COG0406	alpha-ribazole phosphatase activity
T261_RS21650	COG0785	Cytochrome C biogenesis protein
T261_RS21655	COG1333	cytochrome c biogenesis protein
T261_RS21660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
T261_RS21685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
T261_RS21690	COG0109	protoheme IX farnesyltransferase activity
T261_RS21705	COG0163	prenyltransferase activity
T261_RS21715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
T261_RS21735	COG1301	dicarboxylic acid transport
T261_RS21800	COG1404	Belongs to the peptidase S8 family
T261_RS21815	COG1404	Belongs to the peptidase S8 family
T261_RS21830	COG1674	ftsk spoiiie
T261_RS21835	COG1278	Cold shock
T261_RS21840	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
T261_RS21845	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
T261_RS21855	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
T261_RS21865	COG2226	methyltransferase
T261_RS21905	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS21910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS21915	COG0649	NAD binding
T261_RS21925	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
T261_RS21930	COG1034	ATP synthesis coupled electron transport
T261_RS21935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
T261_RS21940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS21945	COG0839	Belongs to the complex I subunit 6 family
T261_RS21950	COG0713	ATP synthesis coupled electron transport
T261_RS21955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
T261_RS21965	COG1007	ATP synthesis coupled electron transport
T261_RS21985	COG0142	geranyltranstransferase activity
T261_RS22010	COG0702	epimerase
T261_RS22015	COG1013	pyruvate-flavodoxin oxidoreductase activity
T261_RS22020	COG0674	pyruvate-flavodoxin oxidoreductase activity
T261_RS22020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
T261_RS22030	COG4585	Histidine kinase
T261_RS22035	COG4585	Histidine kinase
T261_RS22050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS22055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS22060	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS22065	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
T261_RS22070	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T261_RS22075	COG0839	Belongs to the complex I subunit 6 family
T261_RS22080	COG0713	ATP synthesis coupled electron transport
T261_RS22085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
T261_RS22095	COG1007	ATP synthesis coupled electron transport
T261_RS22100	COG0501	Belongs to the peptidase M48B family
T261_RS22110	COG3304	Inner membrane component domain
T261_RS22120	COG1666	GTP binding
T261_RS22130	COG0702	epimerase
T261_RS22135	COG0402	S-adenosylhomocysteine deaminase activity
T261_RS22150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T261_RS22155	COG2030	dehydratase
T261_RS22165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
T261_RS22170	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
T261_RS22175	COG0436	Aminotransferase
T261_RS22190	COG0250	Participates in transcription elongation, termination and antitermination
T261_RS22195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
T261_RS22200	COG0081	regulation of translation
T261_RS22215	COG0222	ribosome binding
T261_RS22220	COG0085	RNA polymerase activity
T261_RS22225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
T261_RS22235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
T261_RS22240	COG0049	tRNA binding
T261_RS22245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T261_RS22250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
T261_RS22255	COG0051	transcription antitermination factor activity, RNA binding
T261_RS22260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
T261_RS22265	COG0088	Forms part of the polypeptide exit tunnel
T261_RS22270	COG0089	rRNA binding
T261_RS22275	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
T261_RS22280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
T261_RS22285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
T261_RS22290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
T261_RS22295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
T261_RS22300	COG0255	Belongs to the universal ribosomal protein uL29 family
T261_RS22305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
T261_RS22310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
T261_RS22315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
T261_RS22320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
T261_RS22325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
T261_RS22330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
T261_RS22335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
T261_RS22340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
T261_RS22345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
T261_RS22350	COG1841	ribosomal large subunit assembly
T261_RS22355	COG0200	Binds to the 23S rRNA
T261_RS22365	COG0563	adenylate kinase activity
T261_RS22375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
T261_RS22380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
T261_RS22385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
T261_RS22390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
T261_RS22395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
T261_RS22400	COG0202	RNA polymerase activity
T261_RS22405	COG0203	ribosomal protein L17
T261_RS22410	COG0101	tRNA pseudouridine synthase activity
T261_RS22420	COG0488	(ABC) transporter
T261_RS22425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
T261_RS22430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
T261_RS22435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T261_RS22440	COG1072	(Pantothenic acid kinase))
T261_RS22450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T261_RS22455	COG0736	holo-[acyl-carrier-protein] synthase activity
T261_RS22470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
T261_RS22475	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS22480	COG0802	atpase or kinase
T261_RS22505	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
T261_RS22525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
T261_RS22540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T261_RS22550	COG4221	oxidoreductase activity
T261_RS22560	COG0583	DNA-binding transcription factor activity
T261_RS22575	COG1595	DNA-templated transcription, initiation
T261_RS22585	COG0516	GMP reductase activity
T261_RS22645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
T261_RS22685	COG1960	acyl-CoA dehydrogenase activity
T261_RS22690	COG1960	acyl-CoA dehydrogenase activity
T261_RS22705	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS22710	COG1960	acyl-CoA dehydrogenase activity
T261_RS22730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
T261_RS22745	COG1024	Enoyl-CoA hydratase
T261_RS22760	COG0456	acetyltransferase
T261_RS22765	COG0259	pyridoxamine-phosphate oxidase activity
T261_RS22780	COG2197	response regulator
T261_RS22800	COG1960	acyl-CoA dehydrogenase activity
T261_RS22810	COG1309	transcriptional regulator
T261_RS22820	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
T261_RS22820	COG0515	serine threonine protein kinase
T261_RS22835	COG1024	Enoyl-CoA hydratase
T261_RS22890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS22910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS22955	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
T261_RS22965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T261_RS22985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS23010	COG1686	Belongs to the peptidase S11 family
T261_RS23030	COG0640	Transcriptional regulator
T261_RS23050	COG2205	protein histidine kinase activity
T261_RS23055	COG0514	ATP-dependent DNA helicase (RecQ)
T261_RS23115	COG1846	Transcriptional regulator
T261_RS23140	COG1247	-acetyltransferase
T261_RS23155	COG1376	ErfK ybiS ycfS ynhG family protein
T261_RS23160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
T261_RS23180	COG3191	aminopeptidase activity
T261_RS23225	COG0730	response to heat
T261_RS23230	COG2188	Transcriptional regulator
T261_RS23235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
T261_RS23240	COG0477	Major facilitator Superfamily
T261_RS23245	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
T261_RS23250	COG0789	Transcriptional regulator
T261_RS23260	COG1970	mechanosensitive ion channel activity
T261_RS23265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T261_RS23280	COG3263	regulation of cellular component size
T261_RS23290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
T261_RS23295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
T261_RS23305	COG0315	cyclic pyranopterin monophosphate synthase activity
T261_RS23310	COG0521	Mo-molybdopterin cofactor biosynthetic process
T261_RS23310	COG0315	cyclic pyranopterin monophosphate synthase activity
T261_RS23315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T261_RS23365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T261_RS23390	COG1733	regulation of RNA biosynthetic process
T261_RS23400	COG0789	Transcriptional regulator
T261_RS23410	COG0708	Exodeoxyribonuclease III
T261_RS23415	COG0789	Transcriptional regulator
T261_RS23420	COG2072	flavoprotein involved in K transport
T261_RS23425	COG2267	carboxylic ester hydrolase activity
T261_RS23430	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS23445	COG4946	Tricorn protease homolog
T261_RS23445	COG0793	Belongs to the peptidase S41A family
T261_RS23465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
T261_RS23485	COG1733	regulation of RNA biosynthetic process
T261_RS23495	COG0310	cobalt ion transport
T261_RS23505	COG1122	ATPase activity
T261_RS23510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T261_RS23515	COG1309	transcriptional regulator
T261_RS23530	COG0768	penicillin binding
T261_RS23555	COG0084	hydrolase, TatD family'
T261_RS23560	COG3583	domain protein
T261_RS23565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
T261_RS23570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
T261_RS23575	COG0488	(ABC) transporter
T261_RS23590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
T261_RS23605	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
T261_RS23610	COG2197	response regulator
T261_RS23620	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS23630	COG4106	trans-aconitate 2-methyltransferase activity
T261_RS23635	COG1309	transcriptional regulator
T261_RS23645	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
T261_RS23655	COG0193	aminoacyl-tRNA hydrolase activity
T261_RS23660	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
T261_RS23665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
T261_RS23670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
T261_RS23685	COG4585	Histidine kinase
T261_RS23690	COG2226	methyltransferase
T261_RS23715	COG1316	TRANSCRIPTIONal
T261_RS23725	COG2814	Major facilitator Superfamily
T261_RS23760	COG2815	serine threonine protein kinase
T261_RS23760	COG0515	serine threonine protein kinase
T261_RS23795	COG2814	Major facilitator Superfamily
T261_RS23805	COG2124	cytochrome p450
T261_RS23820	COG0148	phosphopyruvate hydratase activity
T261_RS23855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
T261_RS23860	COG0577	efflux transmembrane transporter activity
T261_RS23865	COG0577	efflux transmembrane transporter activity
T261_RS23865	COG1136	(ABC) transporter
T261_RS23880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
T261_RS23905	COG0183	Belongs to the thiolase family
T261_RS23910	COG2755	lipolytic protein G-D-S-L family
T261_RS23920	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
T261_RS23935	COG1609	Transcriptional regulator
T261_RS23945	COG2986	histidine ammonia-lyase
T261_RS23970	COG1131	(ABC) transporter
T261_RS23985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
T261_RS24000	COG1228	amidohydrolase
T261_RS24010	COG1191	sigma factor activity
T261_RS24015	COG1366	Belongs to the anti-sigma-factor antagonist family
T261_RS24045	COG3104	oligopeptide transport
T261_RS24050	COG0745	RESPONSE REGULATOR receiver
T261_RS24055	COG2205	protein histidine kinase activity
T261_RS24095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
T261_RS24105	COG1316	TRANSCRIPTIONal
T261_RS24135	COG1316	TRANSCRIPTIONal
T261_RS24150	COG1316	TRANSCRIPTIONal
T261_RS24180	COG0778	Nitroreductase
T261_RS24180	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
T261_RS24185	COG0391	Required for morphogenesis under gluconeogenic growth conditions
T261_RS24220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T261_RS24235	COG1482	cell wall glycoprotein biosynthetic process
T261_RS24245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T261_RS24245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T261_RS24245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T261_RS24250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
T261_RS24275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T261_RS24275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T261_RS24290	COG0714	Associated with various cellular activities
T261_RS24310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
T261_RS24315	COG0745	RESPONSE REGULATOR receiver
T261_RS24320	COG5002	protein histidine kinase activity
T261_RS24320	COG5000	phosphorelay sensor kinase activity
T261_RS24325	COG0823	Involved in the tonB-independent uptake of proteins
T261_RS24335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
T261_RS24340	COG2197	response regulator
T261_RS24345	COG3214	Protein conserved in bacteria
T261_RS24355	COG0653	protein targeting
T261_RS24375	COG2902	Dehydrogenase
T261_RS24380	COG1134	teichoic acid transport
T261_RS24390	COG1309	transcriptional regulator
T261_RS24395	COG0463	Glycosyl transferase, family 2
T261_RS24395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
T261_RS24410	COG0463	Glycosyl transferase, family 2
T261_RS24430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
T261_RS24435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
T261_RS24445	COG0395	ABC-type sugar transport system, permease component
T261_RS24450	COG1175	transmembrane transport
T261_RS24455	COG1653	transport
T261_RS24465	COG0515	serine threonine protein kinase
T261_RS24470	COG0515	serine threonine protein kinase
T261_RS24475	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
T261_RS24490	COG2884	Cell division ATP-binding protein ftsE
T261_RS24495	COG2177	Part of the ABC transporter FtsEX involved in
T261_RS24500	COG0793	Belongs to the peptidase S41A family
T261_RS24505	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
T261_RS24515	COG0583	DNA-binding transcription factor activity
T261_RS24525	COG2223	nitrite transmembrane transporter activity
T261_RS24535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
T261_RS24555	COG3973	AAA domain
T261_RS24565	COG0776	regulation of translation
T261_RS24580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T261_RS24585	COG1678	Uncharacterized ACR, COG1678
T261_RS24600	COG3525	Glycosyl hydrolase, family 20, catalytic domain
T261_RS24690	COG0477	Major facilitator Superfamily
T261_RS24720	COG1174	glycine betaine transport
T261_RS24730	COG1174	glycine betaine transport
T261_RS24740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
T261_RS24745	COG0277	FAD linked oxidase domain protein
T261_RS24755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T261_RS24790	COG1335	isochorismatase
T261_RS24800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
T261_RS24810	COG1113	amino acid transport
T261_RS24830	COG1234	tRNA 3'-trailer cleavage
T261_RS24835	COG1263	PTS System
T261_RS24840	COG1263	PTS System
T261_RS24845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
T261_RS24850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
T261_RS24860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
T261_RS24885	COG2205	protein histidine kinase activity
T261_RS24900	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
T261_RS24910	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T261_RS24940	COG2733	membrane
T261_RS24950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
T261_RS24960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
T261_RS24975	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS25005	COG0706	membrane insertase activity
T261_RS25015	COG0673	inositol 2-dehydrogenase activity
T261_RS25030	COG2188	Transcriptional regulator
T261_RS25035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T261_RS25100	COG3397	chitin binding
T261_RS25105	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS25120	COG1126	abc transporter atp-binding protein
T261_RS25125	COG0765	amino acid transport
T261_RS25130	COG0765	amino acid transport
T261_RS25135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T261_RS25145	COG0154	amidase activity
T261_RS25150	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T261_RS25160	COG3473	Maleate cis-trans isomerase
T261_RS25165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS25220	COG0667	Aldo Keto reductase
T261_RS25240	COG0438	transferase activity, transferring glycosyl groups
T261_RS25270	COG0745	RESPONSE REGULATOR receiver
T261_RS25280	COG3979	chitinase
T261_RS25295	COG2910	NAD(P)H-binding
T261_RS25305	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
T261_RS25310	COG4977	sequence-specific DNA binding
T261_RS25325	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T261_RS25340	COG1960	acyl-CoA dehydrogenase activity
T261_RS25355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
T261_RS25360	COG1309	transcriptional regulator
T261_RS25370	COG1946	Acyl-CoA thioesterase
T261_RS25395	COG1131	(ABC) transporter
T261_RS25395	COG0842	Transport permease protein
T261_RS25395	COG1716	ATPase activity
T261_RS25415	COG1472	Belongs to the glycosyl hydrolase 3 family
T261_RS25425	COG0673	inositol 2-dehydrogenase activity
T261_RS25440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
T261_RS25460	COG0586	Pfam SNARE associated Golgi protein
T261_RS25475	COG0673	inositol 2-dehydrogenase activity
T261_RS25480	COG1609	Transcriptional regulator
T261_RS25485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
T261_RS25500	COG2814	Major facilitator Superfamily
T261_RS25505	COG0673	inositol 2-dehydrogenase activity
T261_RS25515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T261_RS25525	COG3718	enzyme involved in inositol metabolism
T261_RS25530	COG3962	Belongs to the TPP enzyme family
T261_RS25545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T261_RS25550	COG1131	(ABC) transporter
T261_RS25560	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
T261_RS25570	COG1077	Cell shape determining protein MreB Mrl
T261_RS25585	COG3903	Transcriptional regulator
T261_RS25585	COG3629	intracellular signal transduction
T261_RS25685	COG0629	single-stranded DNA binding
T261_RS25710	COG2346	COG2346, Truncated hemoglobins
T261_RS25735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T261_RS25745	COG2186	Transcriptional regulator
T261_RS25760	COG1486	melibiose metabolic process
T261_RS25765	COG0395	ABC-type sugar transport system, permease component
T261_RS25770	COG1175	transmembrane transport
T261_RS25780	COG1846	Transcriptional regulator
T261_RS25780	COG1940	carbohydrate kinase activity
T261_RS25785	COG0668	transmembrane transport
T261_RS25825	COG0583	DNA-binding transcription factor activity
T261_RS25830	COG4266	Belongs to the allantoicase family
T261_RS25915	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
T261_RS25920	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
T261_RS25925	COG1113	amino acid transport
T261_RS25930	COG1113	amino acid transport
T261_RS25940	COG1113	amino acid transport
T261_RS25945	COG0698	ribose 5-phosphate isomerase
T261_RS25965	COG3594	Acyltransferase
T261_RS25990	COG0544	peptidyl-prolyl cis-trans isomerase activity
T261_RS25995	COG0740	serine-type endopeptidase activity
T261_RS26000	COG0740	serine-type endopeptidase activity
T261_RS26005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
T261_RS26020	COG0525	valine-tRNA ligase activity
T261_RS26030	COG0768	penicillin binding
T261_RS26035	COG0285	dihydrofolate synthase activity
T261_RS26045	COG0105	UTP biosynthetic process
T261_RS26050	COG1077	Cell shape determining protein MreB Mrl
T261_RS26065	COG0768	penicillin binding
T261_RS26070	COG0772	Belongs to the SEDS family
T261_RS26100	COG1530	ribonuclease E activity
T261_RS26105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
T261_RS26110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
T261_RS26115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
T261_RS26125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
T261_RS26135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
T261_RS26150	COG0501	Belongs to the peptidase M48B family
T261_RS26160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
T261_RS26170	COG0799	negative regulation of ribosome biogenesis
T261_RS26175	COG0588	phosphoglycerate mutase activity
T261_RS26210	COG0495	leucyl-tRNA aminoacylation
T261_RS26220	COG1307	EDD domain protein, DegV family
T261_RS26230	COG1234	tRNA 3'-trailer cleavage
T261_RS26235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
T261_RS26240	COG1959	2 iron, 2 sulfur cluster binding
T261_RS26245	COG2162	N-hydroxyarylamine O-acetyltransferase activity
T261_RS26260	COG0268	Binds directly to 16S ribosomal RNA
T261_RS26265	COG0481	GTPase activity
T261_RS26300	COG1420	regulation of RNA biosynthetic process
T261_RS26305	COG0484	heat shock protein binding
T261_RS26340	COG0537	adenosine 5'-monophosphoramidase activity
T261_RS26345	COG1234	tRNA 3'-trailer cleavage
T261_RS26365	COG1486	melibiose metabolic process
T261_RS26380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
T261_RS26400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
T261_RS26410	COG2211	Major facilitator Superfamily
T261_RS26430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
T261_RS26440	COG2124	cytochrome p450
T261_RS26445	COG2124	cytochrome p450
T261_RS26480	COG1381	Involved in DNA repair and RecF pathway recombination
T261_RS26485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
T261_RS26510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T261_RS26515	COG1121	(ABC) transporter
T261_RS26520	COG3443	Belongs to the bacterial solute-binding protein 9 family
T261_RS26520	COG0803	Belongs to the bacterial solute-binding protein 9 family
T261_RS26525	COG0423	glycine-tRNA ligase activity
T261_RS26570	COG1309	transcriptional regulator
T261_RS26575	COG0667	Aldo Keto reductase
T261_RS26580	COG0477	Major facilitator Superfamily
T261_RS26600	COG1846	Transcriptional regulator
T261_RS26610	COG0477	Major facilitator Superfamily
T261_RS26615	COG0574	Belongs to the PEP-utilizing enzyme family
T261_RS26615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T261_RS26635	COG0477	Major facilitator Superfamily
T261_RS26640	COG0395	ABC-type sugar transport system, permease component
T261_RS26645	COG1175	transmembrane transport
T261_RS26650	COG2182	Extracellular solute-binding protein
T261_RS26700	COG0531	amino acid
T261_RS26710	COG0640	Transcriptional regulator
T261_RS26725	COG2146	nitrite reductase [NAD(P)H] activity
T261_RS26725	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
T261_RS26730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
T261_RS26750	COG1473	amidohydrolase
T261_RS26775	COG0667	Aldo Keto reductase
T261_RS26825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
T261_RS26830	COG0243	molybdopterin cofactor binding
T261_RS26840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
T261_RS26855	COG0358	DNA primase activity
T261_RS26860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T261_RS26865	COG1070	Carbohydrate kinase
T261_RS26900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
T261_RS26905	COG0406	alpha-ribazole phosphatase activity
T261_RS26910	COG1077	Cell shape determining protein MreB Mrl
T261_RS26935	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
T261_RS26945	COG4981	capsule polysaccharide biosynthetic process
T261_RS26950	COG0500	methyltransferase
T261_RS26975	COG0477	Major facilitator Superfamily
T261_RS26980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
T261_RS26990	COG2130	NADP-dependent
T261_RS27000	COG1764	response to oxidative stress
T261_RS27005	COG1609	Transcriptional regulator
T261_RS27010	COG1129	ABC transporter
T261_RS27015	COG1172	Belongs to the binding-protein-dependent transport system permease family
T261_RS27020	COG1879	ABC-type sugar transport system periplasmic component
T261_RS27025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T261_RS27060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS27065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS27070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
T261_RS27095	COG0789	Transcriptional regulator
T261_RS27100	COG0667	Aldo Keto reductase
T261_RS27115	COG2197	response regulator
T261_RS27120	COG4585	Histidine kinase
T261_RS27135	COG1309	transcriptional regulator
T261_RS27140	COG0477	Major facilitator Superfamily
T261_RS27150	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
T261_RS27195	COG1358	cellular component organization or biogenesis
T261_RS27205	COG0586	Pfam SNARE associated Golgi protein
T261_RS27210	COG4585	Histidine kinase
T261_RS27235	COG0800	Aldolase
T261_RS27240	COG4948	Mandelate Racemase Muconate Lactonizing
T261_RS27245	COG2186	Transcriptional regulator
T261_RS27280	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
T261_RS27295	COG1072	(Pantothenic acid kinase))
T261_RS27300	COG0662	Cupin 2, conserved barrel domain protein
T261_RS27305	COG1309	transcriptional regulator
T261_RS27430	COG0477	Major facilitator Superfamily
T261_RS27435	COG0667	Aldo Keto reductase
T261_RS27450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
T261_RS27460	COG2124	cytochrome p450
T261_RS27465	COG0183	Belongs to the thiolase family
T261_RS27480	COG3845	ABC transporter
T261_RS27495	COG1657	PFAM Prenyltransferase squalene oxidase
T261_RS27515	COG1309	transcriptional regulator
T261_RS27520	COG0438	transferase activity, transferring glycosyl groups
T261_RS27545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS27555	COG0860	N-Acetylmuramoyl-L-alanine amidase
T261_RS27565	COG1960	acyl-CoA dehydrogenase activity
T261_RS27570	COG0183	Belongs to the thiolase family
T261_RS27580	COG2197	response regulator
T261_RS27585	COG4585	Histidine kinase
T261_RS27595	COG1131	(ABC) transporter
T261_RS27600	COG2030	dehydratase
T261_RS27610	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS27620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
T261_RS27635	COG0800	Aldolase
T261_RS27640	COG3022	response to hydroperoxide
T261_RS27645	COG0557	exoribonuclease II activity
T261_RS27660	COG4974	Belongs to the 'phage' integrase family
T261_RS27985	COG2226	methyltransferase
T261_RS28020	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS28030	COG3540	Alkaline phosphatase
T261_RS28035	COG2814	Major facilitator Superfamily
T261_RS28040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T261_RS28065	COG0672	)-iron permease
T261_RS28070	COG2837	iron assimilation
T261_RS28085	COG5398	heme oxygenase
T261_RS28110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
T261_RS28130	COG1175	transmembrane transport
T261_RS28135	COG0395	ABC-type sugar transport system, permease component
T261_RS28150	COG1994	Peptidase M50
T261_RS28170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
T261_RS28175	COG0477	Major facilitator Superfamily
T261_RS28180	COG1309	transcriptional regulator
T261_RS28190	COG2814	Major facilitator Superfamily
T261_RS28195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T261_RS28195	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T261_RS28200	COG2132	Multicopper oxidase
T261_RS28210	COG2267	carboxylic ester hydrolase activity
T261_RS28215	COG0174	glutamine synthetase
T261_RS28220	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
T261_RS28230	COG1609	Transcriptional regulator
T261_RS28235	COG0366	Alpha amylase catalytic
T261_RS28240	COG2182	Extracellular solute-binding protein
T261_RS28245	COG1175	transmembrane transport
T261_RS28250	COG3833	ABC-type maltose transport systems, permease component
T261_RS28255	COG0366	Alpha amylase catalytic
T261_RS28355	COG0745	RESPONSE REGULATOR receiver
T261_RS28385	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS28395	COG1695	Transcriptional regulator
T261_RS28400	COG0446	pyridine nucleotide-disulphide oxidoreductase
T261_RS28400	COG1902	pentaerythritol trinitrate reductase activity
T261_RS28500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
T261_RS28505	COG0321	lipoyl(octanoyl) transferase activity
T261_RS28555	COG0508	dehydrogenase complex catalyzes the overall conversion of
T261_RS28560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
T261_RS28565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
T261_RS28570	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
T261_RS28585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
T261_RS28620	COG4585	Histidine kinase
T261_RS28625	COG2197	response regulator
T261_RS28630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
T261_RS28640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
T261_RS28660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T261_RS28670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
T261_RS28675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
T261_RS28680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
T261_RS28690	COG1376	ErfK ybiS ycfS ynhG family protein
T261_RS28700	COG1845	cytochrome c oxidase, subunit III
T261_RS28705	COG2010	Cytochrome c
T261_RS28710	COG0723	plastoquinol--plastocyanin reductase activity
T261_RS28715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
T261_RS28720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
T261_RS28725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T261_RS28765	COG0438	transferase activity, transferring glycosyl groups
T261_RS28785	COG0003	Pfam Anion-transporting ATPase
T261_RS28795	COG1940	carbohydrate kinase activity
T261_RS28825	COG2197	response regulator
T261_RS28830	COG0205	6-phosphofructokinase activity
T261_RS28835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T261_RS28845	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
T261_RS28855	COG2193	ferroxidase activity
T261_RS28860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
T261_RS28870	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
T261_RS28875	COG0515	serine threonine protein kinase
T261_RS28875	COG2815	serine threonine protein kinase
T261_RS28880	COG2022	thiamine diphosphate biosynthetic process
T261_RS28890	COG2022	thiamine diphosphate biosynthetic process
T261_RS28890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T261_RS28905	COG0352	thiamine-phosphate diphosphorylase activity
T261_RS28920	COG1233	COG1233 Phytoene dehydrogenase and related
T261_RS28930	COG1309	transcriptional regulator
T261_RS28940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
T261_RS28950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
T261_RS28970	COG0714	Associated with various cellular activities
T261_RS28980	COG0275	rRNA processing
T261_RS28995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
T261_RS29000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T261_RS29005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T261_RS29010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
T261_RS29020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
T261_RS29025	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
T261_RS29045	COG1799	cell septum assembly
T261_RS29055	COG3599	regulation of cell shape
T261_RS29060	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
T261_RS29075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
T261_RS29135	COG0587	DNA-directed DNA polymerase activity
T261_RS29145	COG1432	Conserved Protein
T261_RS29165	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
T261_RS29180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
T261_RS29185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
T261_RS29190	COG0131	Imidazoleglycerol-phosphate dehydratase
T261_RS29200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
T261_RS29205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
T261_RS29210	COG0251	oxidation-reduction process
T261_RS29215	COG0107	imidazoleglycerol-phosphate synthase activity
T261_RS29220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
T261_RS29225	COG1053	succinate dehydrogenase
T261_RS29235	COG0583	DNA-binding transcription factor activity
T261_RS29245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
T261_RS29250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T261_RS29270	COG0134	indole-3-glycerol-phosphate synthase activity
T261_RS29275	COG0133	tryptophan synthase activity
T261_RS29280	COG0159	tryptophan synthase activity
T261_RS29290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
T261_RS29300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
T261_RS29330	COG0067	glutamate synthase
T261_RS29330	COG0069	glutamate synthase activity
T261_RS29330	COG0070	glutamate synthase
T261_RS29345	COG0640	Transcriptional regulator
T261_RS29355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T261_RS29365	COG2267	carboxylic ester hydrolase activity
T261_RS29380	COG1470	cell adhesion involved in biofilm formation
T261_RS29380	COG0366	Alpha amylase catalytic
T261_RS29405	COG0737	Belongs to the 5'-nucleotidase family
T261_RS29420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
T261_RS29450	COG0559	Belongs to the binding-protein-dependent transport system permease family
T261_RS29460	COG2050	protein possibly involved in aromatic compounds catabolism
T261_RS29490	COG1643	Atp-dependent helicase
T261_RS29510	COG0237	dephospho-CoA kinase activity
T261_RS29535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
T261_RS29590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
T261_RS29595	COG0584	glycerophosphoryl diester phosphodiesterase
T261_RS29600	COG0556	nucleotide-excision repair
T261_RS29645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
T261_RS29655	COG1609	Transcriptional regulator
T261_RS29660	COG1063	alcohol dehydrogenase
T261_RS29665	COG2814	Major facilitator Superfamily
T261_RS29690	COG0322	excinuclease ABC activity
T261_RS29695	COG1660	Displays ATPase and GTPase activities
T261_RS29700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
T261_RS29705	COG1481	regulation of sporulation
T261_RS29710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
T261_RS29715	COG0126	phosphoglycerate kinase activity
T261_RS29720	COG0149	triose-phosphate isomerase activity
T261_RS29725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
T261_RS29735	COG0166	Belongs to the GPI family
T261_RS29745	COG0363	glucosamine-6-phosphate deaminase activity
T261_RS29760	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
T261_RS29765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
T261_RS29770	COG0109	protoheme IX farnesyltransferase activity
T261_RS29810	COG0719	Fe-S assembly protein
T261_RS29820	COG0396	ATPase activity
T261_RS29825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T261_RS29830	COG0822	iron-sulfur transferase activity
T261_RS29840	COG2171	N-acyltransferase activity
T261_RS29890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
T261_RS29905	COG4585	Histidine kinase
T261_RS29920	COG2226	methyltransferase
T261_RS29940	COG1917	Cupin 2, conserved barrel domain protein
T261_RS29945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
T261_RS29960	COG0385	Bile acid
T261_RS29975	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
T261_RS29985	COG1797	cobyrinic acid a,c-diamide synthase activity
T261_RS29990	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
T261_RS30000	COG1492	cobalamin metabolic process
T261_RS30020	COG1653	transport
T261_RS30035	COG0235	Class ii aldolase
T261_RS30055	COG0488	(ABC) transporter
T261_RS30065	COG1024	Enoyl-CoA hydratase
T261_RS30075	COG1302	Protein conserved in bacteria
T261_RS30105	COG3387	PFAM Glycoside hydrolase 15-related
T261_RS30190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
T261_RS30195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
T261_RS30215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
T261_RS30230	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS30235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
T261_RS30245	COG2186	Transcriptional regulator
T261_RS30250	COG2807	transmembrane transport
T261_RS30265	COG3830	Belongs to the UPF0237 family
T261_RS30265	COG0560	Phosphoserine phosphatase
T261_RS30270	COG1131	(ABC) transporter
T261_RS30270	COG0842	Transport permease protein
T261_RS30270	COG1716	ATPase activity
T261_RS30280	COG4585	Histidine kinase
T261_RS30285	COG2197	response regulator
T261_RS30305	COG1119	ATPase activity
T261_RS30330	COG1881	PFAM PEBP family protein
T261_RS30340	COG2094	Belongs to the DNA glycosylase MPG family
T261_RS30380	COG3486	L-lysine 6-monooxygenase (NADPH) activity
T261_RS30385	COG0076	glutamate decarboxylase activity
T261_RS30395	COG0647	UMP catabolic process
T261_RS30410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T261_RS30415	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T261_RS30420	COG1120	ATPase activity
T261_RS30440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
T261_RS30450	COG0497	DNA recombination
T261_RS30490	COG3387	PFAM Glycoside hydrolase 15-related
T261_RS30495	COG0504	CTP synthase activity
T261_RS30500	COG0494	nUDIX hydrolase
T261_RS30510	COG0686	Belongs to the AlaDH PNT family
T261_RS30525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
T261_RS30530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
T261_RS30535	COG1187	pseudouridine synthase activity
T261_RS30545	COG3541	Predicted nucleotidyltransferase
T261_RS30565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
T261_RS30575	COG1160	GTP binding
T261_RS30595	COG0438	transferase activity, transferring glycosyl groups
T261_RS30610	COG0671	phosphoesterase, PA-phosphatase related
T261_RS30620	COG0477	Major facilitator Superfamily
T261_RS30625	COG1960	acyl-CoA dehydrogenase activity
T261_RS30630	COG1799	cell septum assembly
T261_RS30635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T261_RS30645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS30650	COG0765	amino acid transport
T261_RS30670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T261_RS30675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS30695	COG0330	HflC and HflK could
T261_RS30715	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS30725	COG0587	DNA-directed DNA polymerase activity
T261_RS30730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
T261_RS30755	COG0531	amino acid
T261_RS30760	COG1522	sequence-specific DNA binding
T261_RS30770	COG2226	methyltransferase
T261_RS30775	COG0456	acetyltransferase
T261_RS30780	COG0367	asparagine synthase
T261_RS30785	COG1725	Transcriptional regulator
T261_RS30790	COG1834	amidinotransferase
T261_RS30805	COG2814	Major facilitator Superfamily
T261_RS30830	COG2197	response regulator
T261_RS30835	COG0604	alcohol dehydrogenase
T261_RS30835	COG3321	synthase
T261_RS30840	COG3321	synthase
T261_RS30840	COG0604	alcohol dehydrogenase
T261_RS30915	COG4770	biotin carboxylase activity
T261_RS30925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
T261_RS30930	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS30975	COG2814	Major facilitator Superfamily
T261_RS30975	COG0477	Major facilitator Superfamily
T261_RS30980	COG2188	Transcriptional regulator
T261_RS30985	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
T261_RS30990	COG1309	transcriptional regulator
T261_RS30995	COG2851	Citrate transporter
T261_RS31040	COG1960	acyl-CoA dehydrogenase activity
T261_RS31090	COG0596	Alpha beta hydrolase
T261_RS31095	COG0477	Major facilitator Superfamily
T261_RS31105	COG2197	response regulator
T261_RS31115	COG3876	Protein conserved in bacteria
T261_RS31125	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS31130	COG1309	transcriptional regulator
T261_RS31135	COG1960	acyl-CoA dehydrogenase activity
T261_RS31155	COG2149	membrane
T261_RS31160	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
T261_RS31200	COG2205	protein histidine kinase activity
T261_RS31205	COG0745	RESPONSE REGULATOR receiver
T261_RS31230	COG2124	cytochrome p450
T261_RS31235	COG0488	(ABC) transporter
T261_RS31240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
T261_RS31250	COG0564	pseudouridine synthase activity
T261_RS31260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T261_RS31290	COG0667	Aldo Keto reductase
T261_RS31295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS31305	COG0598	Magnesium transport protein CorA
T261_RS31325	COG0215	cysteine-tRNA ligase activity
T261_RS31345	COG4948	Mandelate Racemase Muconate Lactonizing
T261_RS31350	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS31360	COG1129	ABC transporter
T261_RS31390	COG3293	Transposase
T261_RS31395	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS31400	COG2186	Transcriptional regulator
T261_RS31410	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
T261_RS31415	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
T261_RS31420	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T261_RS31425	COG1414	Transcriptional regulator
T261_RS31430	COG0646	methionine synthase
T261_RS31430	COG1410	methionine synthase
T261_RS31435	COG0546	phosphoglycolate phosphatase activity
T261_RS31445	COG4166	transmembrane transport
T261_RS31450	COG2197	response regulator
T261_RS31460	COG0517	IMP dehydrogenase activity
T261_RS31460	COG1994	Peptidase M50
T261_RS31480	COG1222	aaa ATPase
T261_RS31485	COG4122	O-methyltransferase activity
T261_RS31500	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
T261_RS31505	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
T261_RS31510	COG1609	Transcriptional regulator
T261_RS31520	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
T261_RS31525	COG0544	peptidyl-prolyl cis-trans isomerase activity
T261_RS31535	COG2378	regulation of single-species biofilm formation
T261_RS31555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
T261_RS31560	COG0805	protein transport
T261_RS31570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS31600	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T261_RS31605	COG0517	IMP dehydrogenase activity
T261_RS31605	COG4175	Glycine betaine
T261_RS31610	COG4176	ABC-type proline glycine betaine transport system permease component
T261_RS31625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T261_RS31640	COG2233	PERMEase
T261_RS31660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
T261_RS31665	COG0531	amino acid
T261_RS31670	COG2186	Transcriptional regulator
T261_RS31680	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS31715	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T261_RS31725	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
T261_RS31730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
T261_RS31735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
T261_RS31740	COG5002	protein histidine kinase activity
T261_RS31745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
T261_RS31750	COG0072	phenylalanine-tRNA ligase activity
T261_RS31750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T261_RS31770	COG1649	PFAM Uncharacterised BCR, COG1649
T261_RS31780	COG0697	spore germination
T261_RS31830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
T261_RS31835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
T261_RS31840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
T261_RS31845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
T261_RS31850	COG1438	arginine binding
T261_RS31855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
T261_RS31860	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
T261_RS31880	COG0137	argininosuccinate synthase activity
T261_RS31885	COG0165	Argininosuccinate lyase
T261_RS31900	COG0477	Major facilitator Superfamily
T261_RS31920	COG0584	glycerophosphoryl diester phosphodiesterase
T261_RS31945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
T261_RS31950	COG2011	ABC-type metal ion transport system permease component
T261_RS31955	COG1464	Belongs to the NlpA lipoprotein family
T261_RS31970	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
T261_RS31975	COG1648	precorrin-2 dehydrogenase activity
T261_RS31975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
T261_RS32035	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T261_RS32090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
T261_RS32105	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
T261_RS32135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T261_RS32140	COG1560	Kdo2-lipid A biosynthetic process
T261_RS32145	COG0438	transferase activity, transferring glycosyl groups
T261_RS32155	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
T261_RS32160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
T261_RS32165	COG0217	transcriptional regulatory protein
T261_RS32170	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
T261_RS32175	COG0632	four-way junction helicase activity
T261_RS32180	COG2255	four-way junction helicase activity
T261_RS32190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T261_RS32195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T261_RS32200	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T261_RS32205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
T261_RS32210	COG1196	nuclear chromosome segregation
T261_RS32215	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
T261_RS32225	COG0124	histidyl-tRNA synthetase
T261_RS32245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
T261_RS32260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
T261_RS32265	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
T261_RS32270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
T261_RS32275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
T261_RS32280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
T261_RS32285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
T261_RS32290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
T261_RS32295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
T261_RS32305	COG0006	proline dipeptidase activity
T261_RS32310	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
T261_RS32315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T261_RS32325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
T261_RS32330	COG0540	Belongs to the ATCase OTCase family
T261_RS32335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
T261_RS32345	COG0505	Belongs to the CarA family
T261_RS32350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
T261_RS32355	COG0167	dihydroorotate dehydrogenase activity
T261_RS32360	COG0284	orotidine-5'-phosphate decarboxylase activity
T261_RS32385	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
T261_RS32400	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
T261_RS32415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
T261_RS32420	COG2390	Transcriptional regulator
T261_RS32435	COG0531	amino acid
T261_RS32455	COG2205	protein histidine kinase activity
T261_RS32465	COG0477	Major facilitator Superfamily
T261_RS32475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T261_RS32490	COG2233	PERMEase
T261_RS32505	COG2223	nitrite transmembrane transporter activity
T261_RS32525	COG3201	nicotinamide mononucleotide transporter
T261_RS32530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T261_RS32530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T261_RS32535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
T261_RS32540	COG0140	phosphoribosyl-ATP diphosphatase activity
T261_RS32545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
T261_RS32595	COG0745	RESPONSE REGULATOR receiver
T261_RS32620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T261_RS32625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T261_RS32645	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS32665	COG0667	Aldo Keto reductase
T261_RS32695	COG2124	cytochrome p450
T261_RS32700	COG1819	glycosyl
T261_RS32740	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
T261_RS32855	COG0477	Major facilitator Superfamily
T261_RS32860	COG2340	Cysteine-rich secretory protein family
T261_RS32875	COG0657	acetylesterase activity
T261_RS32885	COG0477	Major facilitator Superfamily
T261_RS32905	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS32965	COG0765	amino acid transport
T261_RS32975	COG0584	glycerophosphoryl diester phosphodiesterase
T261_RS32995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS33045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
T261_RS33050	COG2318	DinB family
T261_RS33075	COG3345	alpha-galactosidase
T261_RS33080	COG0494	nUDIX hydrolase
T261_RS33090	COG0445	tRNA wobble uridine modification
T261_RS33105	COG4585	Histidine kinase
T261_RS33110	COG2197	response regulator
T261_RS33130	COG2223	nitrite transmembrane transporter activity
T261_RS33135	COG1940	carbohydrate kinase activity
T261_RS33190	COG1349	DNA-binding transcription factor activity
T261_RS33200	COG0464	growth
T261_RS33220	COG0633	Ferredoxin
T261_RS33220	COG3217	Mosc domain protein beta barrel domain protein
T261_RS33235	COG0463	Glycosyl transferase, family 2
T261_RS33240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
T261_RS33250	COG2816	NAD+ diphosphatase activity
T261_RS33265	COG1968	undecaprenyl-diphosphatase activity
T261_RS33270	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
T261_RS33280	COG2124	cytochrome p450
T261_RS33285	COG1309	transcriptional regulator
T261_RS33290	COG2124	cytochrome p450
T261_RS33325	COG0647	UMP catabolic process
T261_RS33335	COG1793	dna ligase
T261_RS33350	COG1063	alcohol dehydrogenase
T261_RS33355	COG0395	ABC-type sugar transport system, permease component
T261_RS33385	COG0583	DNA-binding transcription factor activity
T261_RS33400	COG1012	belongs to the aldehyde dehydrogenase family
T261_RS33425	COG1461	Dihydroxyacetone kinase
T261_RS33430	COG2376	Dihydroxyacetone kinase
T261_RS33465	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
T261_RS33470	COG2192	nodulation
T261_RS33485	COG4106	trans-aconitate 2-methyltransferase activity
T261_RS33525	COG0142	geranyltranstransferase activity
T261_RS33530	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
T261_RS33610	COG1674	ftsk spoiiie
T261_RS33725	COG0305	Participates in initiation and elongation during chromosome replication
T261_RS33810	COG3586	endonuclease activity
T261_RS33815	COG3415	Transposase
T261_RS33815	COG2801	Transposase and inactivated derivatives
T261_RS33840	COG1857	crispr-associated protein
T261_RS33920	COG3293	Transposase
T261_RS33970	COG1051	belongs to the nudix hydrolase family
T261_RS34010	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
T261_RS34020	COG1007	ATP synthesis coupled electron transport
T261_RS34025	COG1006	Multisubunit Na H antiporter MnhC subunit
T261_RS34030	COG2111	Na H antiporter
T261_RS34050	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
T261_RS34080	COG4264	IucA IucC family
T261_RS34085	COG2814	Major facilitator Superfamily
T261_RS34095	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
T261_RS34100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T261_RS34105	COG1120	ATPase activity
T261_RS34110	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T261_RS34115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T261_RS34135	COG1960	acyl-CoA dehydrogenase activity
T261_RS34145	COG0515	serine threonine protein kinase
T261_RS34160	COG2070	2-Nitropropane dioxygenase
T261_RS34175	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS34205	COG1024	Enoyl-CoA hydratase
T261_RS34275	COG0438	transferase activity, transferring glycosyl groups
T261_RS34300	COG1984	allophanate hydrolase subunit 2
T261_RS34305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
T261_RS34310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
T261_RS34330	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
T261_RS34360	COG2146	nitrite reductase [NAD(P)H] activity
T261_RS34410	COG0596	Alpha beta hydrolase
T261_RS34415	COG1309	transcriptional regulator
T261_RS34425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
T261_RS34430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
T261_RS34450	COG1177	transmembrane transport
T261_RS34460	COG0494	nUDIX hydrolase
T261_RS34475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
T261_RS34480	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
T261_RS34490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
T261_RS34500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T261_RS34515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T261_RS34515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T261_RS34530	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
T261_RS34550	COG1716	ATPase activity
T261_RS34570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
T261_RS34580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
T261_RS34580	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
T261_RS34610	COG1695	Transcriptional regulator
T261_RS34655	COG2826	transposase and inactivated derivatives, IS30 family
T261_RS34660	COG0697	spore germination
T261_RS34665	COG0583	DNA-binding transcription factor activity
T261_RS34670	COG0825	malonyl-CoA metabolic process
T261_RS34670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
T261_RS34675	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS34700	COG0723	plastoquinol--plastocyanin reductase activity
T261_RS34770	COG2963	transposase activity
T261_RS34775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T261_RS34780	COG2814	Major facilitator Superfamily
T261_RS34785	COG1959	2 iron, 2 sulfur cluster binding
T261_RS34805	COG2824	Alkylphosphonate utilization operon protein PhnA
T261_RS34835	COG0596	Alpha beta hydrolase
T261_RS34845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
T261_RS34870	COG0815	Transfers the fatty acyl group on membrane lipoproteins
T261_RS34880	COG1132	(ABC) transporter
T261_RS34895	COG0386	Belongs to the glutathione peroxidase family
T261_RS34915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
T261_RS34970	COG0438	transferase activity, transferring glycosyl groups
T261_RS34985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
T261_RS34985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
T261_RS34995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T261_RS35030	COG2015	COG2015, Alkyl sulfatase and related hydrolases
T261_RS35035	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS35040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS35080	COG0583	DNA-binding transcription factor activity
T261_RS35095	COG3835	regulator
T261_RS35100	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
T261_RS35105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS35120	COG3585	molybdate ion transport
T261_RS35140	COG2223	nitrite transmembrane transporter activity
T261_RS35145	COG2207	Transcriptional regulator
T261_RS35170	COG1024	Enoyl-CoA hydratase
T261_RS35170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
T261_RS35175	COG0745	RESPONSE REGULATOR receiver
T261_RS35215	COG0181	hydroxymethylbilane synthase activity
T261_RS35235	COG1063	alcohol dehydrogenase
T261_RS35240	COG0156	8-amino-7-oxononanoate synthase activity
T261_RS35250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
T261_RS35250	COG1796	DNA polymerase
T261_RS35265	COG2274	protein secretion by the type I secretion system
T261_RS35285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T261_RS35290	COG1120	ATPase activity
T261_RS35340	COG0640	Transcriptional regulator
T261_RS35375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T261_RS35380	COG4638	Rieske (2fe-2S)
T261_RS35385	COG0477	Major facilitator Superfamily
T261_RS35390	COG1957	nucleoside hydrolase
T261_RS35395	COG1609	Transcriptional regulator
T261_RS35410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T261_RS35430	COG0583	DNA-binding transcription factor activity
T261_RS35435	COG0702	epimerase
T261_RS35445	COG0339	signal peptide processing
T261_RS35460	COG4214	carbohydrate transport
T261_RS35470	COG4213	ABC transporter substrate-binding protein
T261_RS35505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
T261_RS35515	COG4565	transcriptional regulatory protein
T261_RS35520	COG3290	protein histidine kinase activity
T261_RS35530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
T261_RS35600	COG2267	carboxylic ester hydrolase activity
T261_RS35615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS35620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
T261_RS35625	COG2080	2 iron, 2 sulfur cluster binding
T261_RS35635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T261_RS35645	COG2318	DinB family
T261_RS35670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
T261_RS35685	COG2326	polyphosphate kinase activity
T261_RS35765	COG0789	Transcriptional regulator
T261_RS35785	COG1172	Belongs to the binding-protein-dependent transport system permease family
T261_RS35790	COG1129	ABC transporter
T261_RS35815	COG0009	L-threonylcarbamoyladenylate synthase
T261_RS35860	COG0531	amino acid
T261_RS35890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T261_RS35895	COG4948	Mandelate Racemase Muconate Lactonizing
T261_RS35905	COG2226	methyltransferase
T261_RS35910	COG0747	negative chemotaxis
T261_RS35920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T261_RS35945	COG0668	transmembrane transport
T261_RS35950	COG1819	glycosyl
T261_RS35965	COG0395	ABC-type sugar transport system, permease component
T261_RS35985	COG2814	Major facilitator Superfamily
T261_RS35995	COG1063	alcohol dehydrogenase
T261_RS36000	COG1070	Carbohydrate kinase
T261_RS36075	COG3864	Putative metallopeptidase domain
T261_RS36100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS36125	COG4171	peptide transport system, permease
T261_RS36150	COG0019	diaminopimelate decarboxylase activity
T261_RS36155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T261_RS36160	COG0534	Mate efflux family protein
T261_RS36165	COG0454	-acetyltransferase
T261_RS36175	COG0180	Tryptophanyl-tRNA synthetase
T261_RS36180	COG0583	DNA-binding transcription factor activity
T261_RS36190	COG4608	Belongs to the ABC transporter superfamily
T261_RS36200	COG0601	transmembrane transport
T261_RS36205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T261_RS36210	COG0747	negative chemotaxis
T261_RS36235	COG3938	Belongs to the proline racemase family
T261_RS36245	COG1802	Transcriptional regulator
T261_RS36285	COG1414	Transcriptional regulator
T261_RS36315	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS36320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
T261_RS36325	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS36355	COG1132	(ABC) transporter
T261_RS36385	COG3570	aminoglycoside hydroxyurea antibiotic resistance kinase
T261_RS36445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T261_RS36450	COG2226	methyltransferase
T261_RS36450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS36450	COG3433	isochorismatase activity
T261_RS36505	COG1132	(ABC) transporter
T261_RS36580	COG0702	epimerase
T261_RS36620	COG2010	Cytochrome c
T261_RS36620	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS36640	COG1595	DNA-templated transcription, initiation
T261_RS36660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
T261_RS36675	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
T261_RS36680	COG3629	intracellular signal transduction
T261_RS36680	COG3903	Transcriptional regulator
T261_RS36695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS36735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS36750	COG0242	peptide deformylase activity
T261_RS36760	COG0596	Alpha beta hydrolase
T261_RS36765	COG1309	transcriptional regulator
T261_RS36775	COG1595	DNA-templated transcription, initiation
T261_RS36780	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS36785	COG2076	Multidrug Resistance protein
T261_RS36790	COG3226	Transcriptional regulator
T261_RS36810	COG0583	DNA-binding transcription factor activity
T261_RS36820	COG0640	Transcriptional regulator
T261_RS36825	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
T261_RS36880	COG1960	acyl-CoA dehydrogenase activity
T261_RS36885	COG1960	acyl-CoA dehydrogenase activity
T261_RS36890	COG0318	PFAM AMP-dependent synthetase and ligase
T261_RS36900	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
T261_RS36910	COG2223	nitrite transmembrane transporter activity
T261_RS36915	COG1228	amidohydrolase
T261_RS36920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
T261_RS36960	COG1595	DNA-templated transcription, initiation
T261_RS36980	COG2018	Roadblock/LC7 domain
T261_RS37005	COG0477	Major facilitator Superfamily
T261_RS37040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
T261_RS37050	COG2226	methyltransferase
T261_RS37080	COG4044	May play a role in the intracellular transport of hydrophobic ligands
T261_RS37090	COG2814	Major facilitator Superfamily
T261_RS37115	COG4221	oxidoreductase activity
T261_RS37125	COG0714	Associated with various cellular activities
T261_RS37195	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
T261_RS37220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
T261_RS37225	COG4941	Belongs to the sigma-70 factor family
T261_RS37230	COG3795	YCII-related domain
T261_RS37290	COG0596	Alpha beta hydrolase
T261_RS37320	COG4221	oxidoreductase activity
T261_RS37335	COG1733	regulation of RNA biosynthetic process
T261_RS37350	COG2267	carboxylic ester hydrolase activity
T261_RS37355	COG3226	Transcriptional regulator
T261_RS37380	COG1335	isochorismatase
T261_RS37415	COG0583	DNA-binding transcription factor activity
T261_RS37430	COG2208	phosphoserine phosphatase activity
T261_RS37430	COG2770	Histidine kinase
T261_RS37495	COG0667	Aldo Keto reductase
T261_RS37500	COG2175	clavaminate synthase activity
T261_RS37505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
T261_RS37520	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS37565	COG0673	inositol 2-dehydrogenase activity
T261_RS37585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS37615	COG2910	NAD(P)H-binding
T261_RS37725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS37750	COG0583	DNA-binding transcription factor activity
T261_RS37760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
T261_RS37770	COG1960	acyl-CoA dehydrogenase activity
T261_RS37775	COG1960	acyl-CoA dehydrogenase activity
T261_RS37800	COG0702	epimerase
T261_RS37805	COG0596	Alpha beta hydrolase
T261_RS37815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS37825	COG4585	Histidine kinase
T261_RS37830	COG2197	response regulator
T261_RS37840	COG2272	Belongs to the type-B carboxylesterase lipase family
T261_RS37845	COG0789	Transcriptional regulator
T261_RS37855	COG1063	alcohol dehydrogenase
T261_RS37860	COG0657	acetylesterase activity
T261_RS37865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
T261_RS37870	COG1414	Transcriptional regulator
T261_RS37890	COG3321	synthase
T261_RS37890	COG0604	alcohol dehydrogenase
T261_RS37895	COG2826	transposase and inactivated derivatives, IS30 family
T261_RS37905	COG3321	synthase
T261_RS37905	COG0604	alcohol dehydrogenase
T261_RS37920	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
T261_RS37965	COG0604	alcohol dehydrogenase
T261_RS37965	COG3321	synthase
T261_RS38010	COG3848	Pyruvate phosphate dikinase
T261_RS38010	COG0574	Belongs to the PEP-utilizing enzyme family
T261_RS38030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
T261_RS38050	COG0367	asparagine synthase
T261_RS38075	COG0438	transferase activity, transferring glycosyl groups
T261_RS38085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
T261_RS38100	COG4310	Domain of unknown function (DUF2172)
T261_RS38110	COG1215	transferase activity, transferring glycosyl groups
T261_RS38120	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
T261_RS38125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
T261_RS38155	COG2124	cytochrome p450
T261_RS38180	COG1316	TRANSCRIPTIONal
T261_RS38190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
T261_RS38205	COG1846	Transcriptional regulator
T261_RS38210	COG1902	pentaerythritol trinitrate reductase activity
T261_RS38220	COG0657	acetylesterase activity
T261_RS38250	COG0069	glutamate synthase activity
T261_RS38260	COG3469	chitinase activity
T261_RS38325	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
T261_RS38335	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T261_RS38340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
T261_RS38345	COG1280	lysine exporter protein (LysE YggA)
T261_RS38435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
T261_RS38480	COG0516	GMP reductase activity
T261_RS38480	COG0517	IMP dehydrogenase activity
T261_RS38485	COG0517	IMP dehydrogenase activity
T261_RS38485	COG0516	GMP reductase activity
T261_RS38495	COG2239	Acts as a magnesium transporter
T261_RS38515	COG0589	response to stress
T261_RS38565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
T261_RS38565	COG2080	2 iron, 2 sulfur cluster binding
T261_RS38580	COG0640	Transcriptional regulator
T261_RS38615	COG2197	response regulator
T261_RS38620	COG1132	(ABC) transporter
T261_RS38625	COG1132	(ABC) transporter
T261_RS38635	COG0515	serine threonine protein kinase
T261_RS38660	COG3293	Transposase
T261_RS38675	COG1733	regulation of RNA biosynthetic process
T261_RS38760	COG0513	Belongs to the DEAD box helicase family
T261_RS38785	COG4249	Peptidase C14 caspase catalytic subunit p20
T261_RS38785	COG2319	Wd-40 repeat
T261_RS38810	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
T261_RS38815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
T261_RS38840	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
T261_RS38870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
T261_RS38870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
T261_RS38925	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS38925	COG3321	synthase
T261_RS38925	COG0604	alcohol dehydrogenase
T261_RS38950	COG4977	sequence-specific DNA binding
T261_RS39020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
T261_RS39070	COG2814	Major facilitator Superfamily
T261_RS39075	COG0367	asparagine synthase
T261_RS39085	COG3226	Transcriptional regulator
T261_RS39090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T261_RS39100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
T261_RS39135	COG0662	Cupin 2, conserved barrel domain protein
T261_RS39145	COG1132	(ABC) transporter
T261_RS39190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
T261_RS39195	COG0235	Class ii aldolase
T261_RS39255	COG0583	DNA-binding transcription factor activity
T261_RS39295	COG2205	protein histidine kinase activity
T261_RS39390	COG1309	transcriptional regulator
T261_RS39420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
T261_RS39430	COG4221	oxidoreductase activity
T261_RS39510	COG1309	transcriptional regulator
T261_RS39530	COG3293	Transposase
T261_RS39535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
T261_RS39585	COG0673	inositol 2-dehydrogenase activity
T261_RS39735	COG0513	Belongs to the DEAD box helicase family
T261_RS39740	COG1278	Cold shock
T261_RS39795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
T261_RS39825	COG1131	(ABC) transporter
T261_RS39860	COG0667	Aldo Keto reductase
T261_RS39875	COG1695	Transcriptional regulator
T261_RS39895	COG2205	protein histidine kinase activity
T261_RS39900	COG0745	RESPONSE REGULATOR receiver
T261_RS39945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
T261_RS39965	COG0583	DNA-binding transcription factor activity
T261_RS40015	COG0702	epimerase
T261_RS40140	COG1653	transport
T261_RS40155	COG0366	Alpha amylase catalytic
T261_RS40175	COG2197	response regulator
T261_RS40180	COG0151	Belongs to the GarS family
T261_RS40185	COG0574	Belongs to the PEP-utilizing enzyme family
T261_RS40185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T261_RS40200	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
T261_RS40205	COG1595	DNA-templated transcription, initiation
T261_RS40215	COG2135	peptidase activity
T261_RS40220	COG0405	Gamma-glutamyltransferase
T261_RS40240	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS40275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
T261_RS40360	COG2205	protein histidine kinase activity
T261_RS40365	COG0745	RESPONSE REGULATOR receiver
T261_RS40395	COG2318	DinB family
T261_RS40450	COG3963	phosphatidate phosphatase activity
T261_RS40455	COG4585	Histidine kinase
T261_RS40460	COG2197	response regulator
T261_RS40480	COG2070	2-Nitropropane dioxygenase
T261_RS40485	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS40510	COG0148	phosphopyruvate hydratase activity
T261_RS40525	COG0583	DNA-binding transcription factor activity
T261_RS40535	COG0667	Aldo Keto reductase
T261_RS40570	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
T261_RS40590	COG4221	oxidoreductase activity
T261_RS40595	COG1028	Short-chain dehydrogenase reductase Sdr
T261_RS40735	COG3547	Transposase (IS116 IS110 IS902 family)
T261_RS40830	COG2340	Cysteine-rich secretory protein family
T261_RS40855	COG1819	glycosyl
T261_RS40860	COG1819	glycosyl
T261_RS40880	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
T261_RS40895	COG2197	response regulator
T261_RS40970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
T261_RS40975	COG0583	DNA-binding transcription factor activity
T261_RS41010	COG3321	synthase
T261_RS41010	COG0604	alcohol dehydrogenase
T261_RS41010	COG3321	synthase
T261_RS41010	COG0604	alcohol dehydrogenase
T261_RS41150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T261_RS41175	COG0456	acetyltransferase
T261_RS41180	COG0515	serine threonine protein kinase
T261_RS41290	COG0242	peptide deformylase activity
T261_RS41305	COG0604	alcohol dehydrogenase
T261_RS41305	COG3321	synthase
T261_RS41355	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
T261_RS41355	COG0515	serine threonine protein kinase
T261_RS41400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
T261_RS41430	COG5002	protein histidine kinase activity
T261_RS41430	COG2205	protein histidine kinase activity
T261_RS41430	COG0784	Response regulator, receiver
T261_RS41450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC